pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6622-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 3,000 1,759E-07 4,232E-04 ! positive regulation of intracellular transport GO:0032388 37 22 3,000 2,646E-07 3,183E-04 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 3,000 2,646E-07 2,122E-04 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 3,000 8,476E-07 5,098E-04 ! regulation of microtubule-based process GO:0032886 78 35 3,000 1,847E-06 8,889E-04 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 2,000 3,342E-06 1,34E-03 ! regulation of intracellular protein transport GO:0033157 80 42 3,000 3,896E-06 1,339E-03 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 3,000 5,637E-06 1,695E-03 ! positive regulation of protein transport GO:0051222 72 46 3,000 5,637E-06 1,507E-03 ! negative regulation of microtubule depolymerization GO:0007026 46 16 2,000 8,446E-06 2,032E-03 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of protein import into nucleus GO:0042307 30 16 2,000 8,446E-06 1,847E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 2,000 1,024E-05 2,052E-03 ! regulation of intracellular transport GO:0032386 101 57 3,000 1,336E-05 2,473E-03 ! phosphatidylinositol metabolic process GO:0046488 36 21 2,000 1,988E-05 3,416E-03 ! calcium-independent cell-cell adhesion GO:0016338 30 22 2,000 2,297E-05 3,685E-03 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 3,000 2,544E-05 3,825E-03 ! negative regulation of ligase activity GO:0051352 112 68 3,000 2,698E-05 3,818E-03 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 3,000 2,698E-05 3,606E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 3,000 2,858E-05 3,619E-03 ! phosphoinositide metabolic process GO:0030384 128 72 3,000 3,382E-05 4,068E-03 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 3,000 3,382E-05 3,875E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 3,000 3,382E-05 3,699E-03 ! regulation of transcription factor import into nucleus GO:0042990 54 26 2,000 3,851E-05 4,028E-03 ! insulin receptor signaling pathway GO:0008286 64 26 2,000 3,851E-05 3,86E-03 ! positive regulation of ligase activity GO:0051351 124 77 3,000 4,406E-05 4,241E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 3,000 4,874E-05 4,51E-03 ! regulation of ligase activity GO:0051340 142 84 3,000 6,199E-05 5,524E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 6,254E-05 5,374E-03 ! early endosome to late endosome transport GO:0045022 12 5 1,000 6,254E-05 5,188E-03 ! regulation of protein transport GO:0051223 154 87 3,000 7,111E-05 5,703E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of protein import into nucleus GO:0042306 63 32 2,000 7,266E-05 5,64E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 3,000 9,221E-05 6,933E-03 GO:0010498|proteasomal protein catabolic process, ! male sex determination GO:0030238 15 6 1,000 9,365E-05 6,828E-03 ! cytoplasmic microtubule organization GO:0031122 14 6 1,000 9,365E-05 6,627E-03 ! regulation of protein localization GO:0032880 176 97 3,000 1,086E-04 7,465E-03 ! cellular response to insulin stimulus GO:0032869 82 37 2,000 1,128E-04 7,539E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,309E-04 8,512E-03 ! regulation of respiratory burst GO:0060263 11 7 1,000 1,309E-04 8,288E-03 ! negative regulation of protein complex disassembly GO:0043242 101 42 2,000 1,652E-04 0,01018877 ! carbohydrate phosphorylation GO:0046835 11 8 1,000 1,742E-04 0,01048068 ! ER overload response GO:0006983 12 8 1,000 1,742E-04 0,01022505 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 1,000 1,742E-04 9,982E-03 ! response to insulin stimulus GO:0032868 95 46 2,000 2,168E-04 0,01213106 ! regulation of developmental growth GO:0048638 15 9 1,000 2,237E-04 0,01223009 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 2,237E-04 0,01195831 ! regulation of glycolysis GO:0006110 21 9 1,000 2,237E-04 0,01169835 ! microtubule bundle formation GO:0001578 21 9 1,000 2,237E-04 0,01144945 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 1,000 2,237E-04 0,01121092 ! receptor clustering GO:0043113 18 9 1,000 2,237E-04 0,01098213 ! protein heterooligomerization GO:0051291 16 9 1,000 2,237E-04 0,01076248 ! postreplication repair GO:0006301 22 9 1,000 2,237E-04 0,01055145 ! regulation of protein complex disassembly GO:0043244 113 49 2,000 2,617E-04 0,0121092 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 2,791E-04 0,01267084 ! midbrain development GO:0030901 13 10 1,000 2,791E-04 0,0124362 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 2,791E-04 0,01221008 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of embryonic development GO:0045995 27 11 1,000 3,406E-04 0,01463297 ! negative regulation of cytoskeleton organization GO:0051494 124 54 2,000 3,492E-04 0,01473833 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 4,08E-04 0,01692633 ! virus-host interaction GO:0019048 29 12 1,000 4,08E-04 0,01663945 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 4,08E-04 0,01636212 ! regulation of RNA splicing GO:0043484 20 12 1,000 4,08E-04 0,01609389 ! integrin-mediated signaling pathway GO:0007229 135 59 2,000 4,535E-04 0,01759876 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 4,814E-04 0,01838613 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! cytoplasmic sequestering of protein GO:0051220 24 13 1,000 4,814E-04 0,01809885 ! response to peptide hormone stimulus GO:0043434 122 61 2,000 5,002E-04 0,01851683 ! actin cytoskeleton reorganization GO:0031532 33 14 1,000 5,608E-04 0,02044199 ! intermediate filament cytoskeleton organization GO:0045104 31 15 1,000 6,46E-04 0,02319688 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 7,37E-04 0,02607817 ! intermediate filament-based process GO:0045103 32 16 1,000 7,37E-04 0,02570023 ! axon cargo transport GO:0008088 43 16 1,000 7,37E-04 0,02533308 ! signal complex assembly GO:0007172 41 17 1,000 8,339E-04 0,02826019 ! inositol metabolic process GO:0006020 28 17 1,000 8,339E-04 0,02786769 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 8,339E-04 0,02748594 ! negative regulation of protein catabolic process GO:0042177 40 17 1,000 8,339E-04 0,02711451 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 9,367E-04 0,03004793 ! peptidyl-serine phosphorylation GO:0018105 38 18 1,000 9,367E-04 0,02965257 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 9,367E-04 0,02926747 ! regulation of catabolic process GO:0009894 161 76 2,000 9,51E-04 0,02933453 ! negative regulation of organelle organization GO:0010639 161 78 2,000 1,025E-03 0,03122983 ! protein oligomerization GO:0051259 139 78 2,000 1,025E-03 0,03083946 ! lipid phosphorylation GO:0046834 35 19 1,000 1,045E-03 0,03104457 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 1,000 1,159E-03 0,03401766 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 1,159E-03 0,03360781 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 1,159E-03 0,03320771 ! peptidyl-serine modification GO:0018209 43 20 1,000 1,159E-03 0,03281703 ! cellular response to hormone stimulus GO:0032870 167 82 2,000 1,185E-03 0,03315512 ! microtubule-based transport GO:0010970 54 22 1,000 1,405E-03 0,03885421 ! protein stabilization GO:0050821 39 22 1,000 1,405E-03 0,03841269 ! positive regulation of DNA replication GO:0045740 43 23 1,000 1,536E-03 0,04153043 ! sex determination GO:0007530 47 23 1,000 1,536E-03 0,04106898 ! negative regulation of catabolic process GO:0009895 50 23 1,000 1,536E-03 0,04061767 ! regulation of cellular catabolic process GO:0031329 52 24 1,000 1,673E-03 0,04375703 ! protein tetramerization GO:0051262 52 24 1,000 1,673E-03 0,04328653 ! receptor metabolic process GO:0043112 46 25 1,000 1,816E-03 0,04647408 ! response to endoplasmic reticulum stress GO:0034976 43 25 1,000 1,816E-03 0,04598488 ! interaction with host GO:0051701 62 25 1,000 1,816E-03 0,04550587 ! liver development GO:0001889 53 25 1,000 1,816E-03 0,04503674 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 1,000 1,964E-03 0,04821316 ! dendrite development GO:0016358 59 28 1,000 2,277E-03 0,05532829 ! ER-nuclear signaling pathway GO:0006984 48 28 1,000 2,277E-03 0,054775 ! peptidyl-tyrosine modification GO:0018212 50 28 1,000 2,277E-03 0,05423268 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 2,787E-03 0,0657382 GO:0043433|negative regulation of transcription factor activity, ! BMP signaling pathway GO:0030509 64 32 1,000 2,968E-03 0,0693268 ! hindbrain development GO:0030902 61 32 1,000 2,968E-03 0,0686602 ! positive regulation of catabolic process GO:0009896 64 32 1,000 2,968E-03 0,06800629 ! negative regulation of protein transport GO:0051224 69 33 1,000 3,154E-03 0,071594 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 1,000 3,346E-03 0,07523495 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 3,543E-03 0,07892705 ! neural tube formation GO:0001841 67 35 1,000 3,543E-03 0,07820295 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 1,000 3,745E-03 0,08191676 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! maintenance of protein location in cell GO:0032507 86 36 1,000 3,745E-03 0,08117877 ! establishment or maintenance of cell polarity GO:0007163 83 37 1,000 3,953E-03 0,08491287 ! negative regulation of DNA binding GO:0043392 68 37 1,000 3,953E-03 0,08416142 ! regulation of protein stability GO:0031647 73 37 1,000 3,953E-03 0,08342317 ! glycogen metabolic process GO:0005977 61 37 1,000 3,953E-03 0,08269775 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 4,166E-03 0,08639868 ! mitotic cell cycle checkpoint GO:0007093 76 38 1,000 4,166E-03 0,08566023 ! carbohydrate homeostasis GO:0033500 53 38 1,000 4,166E-03 0,0849343 GO:0042593|glucose homeostasis, ! embryonic epithelial tube formation GO:0001838 72 38 1,000 4,166E-03 0,08422057 ! glucan metabolic process GO:0044042 62 38 1,000 4,166E-03 0,08351873 GO:0006073|cellular glucan metabolic process, ! negative regulation of binding GO:0051100 72 40 1,000 4,607E-03 0,09160189 ! maintenance of protein location GO:0045185 91 40 1,000 4,607E-03 0,09085105 ! polyol metabolic process GO:0019751 66 41 1,000 4,835E-03 0,09457946 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 1,000 5,069E-03 0,09834733 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 1,000 5,307E-03 0,10215321 ! energy reserve metabolic process GO:0006112 74 43 1,000 5,307E-03 0,10134247 ! neural tube development GO:0021915 77 43 1,000 5,307E-03 0,1005445 ! maintenance of location in cell GO:0051651 97 44 1,000 5,551E-03 0,1043395 ! regulation of gene-specific transcription GO:0032583 96 46 1,000 6,053E-03 0,11290292 ! endosome transport GO:0016197 108 47 1,000 6,312E-03 0,11682359 ! protein homooligomerization GO:0051260 76 47 1,000 6,312E-03 0,11593181 ! morphogenesis of embryonic epithelium GO:0016331 91 48 1,000 6,576E-03 0,11986081 ! epithelial tube morphogenesis GO:0060562 98 51 1,000 7,397E-03 0,13380822 ! positive regulation of growth GO:0045927 90 52 1,000 7,68E-03 0,1378978 ! response to UV GO:0009411 104 53 1,000 7,968E-03 0,14201314 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 8,559E-03 0,15142234 ! regulation of protein catabolic process GO:0042176 116 55 1,000 8,559E-03 0,15031707 ! heart morphogenesis GO:0003007 97 55 1,000 8,559E-03 0,14922781 ! regulation of DNA replication GO:0006275 101 56 1,000 8,862E-03 0,15339217 ! positive regulation of cell migration GO:0030335 126 57 1,000 9,169E-03 0,15757856 ! lipid modification GO:0030258 97 57 1,000 9,169E-03 0,15646098 ! maintenance of location GO:0051235 118 57 1,000 9,169E-03 0,15535914 ! protein amino acid autophosphorylation GO:0046777 141 60 1,000 0,01011942 0,17026104 ! viral reproductive process GO:0022415 126 62 1,000 0,01077619 0,18005213 ! positive regulation of cell motion GO:0051272 146 64 1,000 0,01145133 0,19001307 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 1,000 0,01214465 0,20013711 ! actin filament organization GO:0007015 148 66 1,000 0,01214465 0,19877563 ! negative regulation of protein kinase activity GO:0006469 130 67 1,000 0,01249806 0,20317793 ! activation of MAPK activity GO:0000187 115 67 1,000 0,01249806 0,20181432 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,01255477 0,20137849 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,01255477 0,20004485 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01255477 0,19872877 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,01255477 0,19742989 ! neuron fate determination GO:0048664 7 5 0,000 0,01255477 0,19614788 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01255477 0,19488241 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,01255477 0,19363316 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,01255477 0,19239983 ! polyol transport GO:0015791 12 5 0,000 0,01255477 0,19118211 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,01255477 0,1899797 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01255477 0,18879233 ! response to superoxide GO:0000303 10 5 0,000 0,01255477 0,18761971 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01255477 0,18646156 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,01255477 0,18531763 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,01255477 0,18418764 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01255477 0,18307135 ! female meiosis GO:0007143 7 5 0,000 0,01255477 0,18196851 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01255477 0,18087888 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01255477 0,17980222 ! cobalt ion transport GO:0006824 11 5 0,000 0,01255477 0,1787383 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,01255477 0,1776869 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,01255477 0,1766478 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,01255477 0,17562077 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01255477 0,17460562 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01255477 0,17360214 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,01255477 0,17261013 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,01255477 0,17162939 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01255477 0,17065973 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,01255477 0,16970097 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,01255477 0,16875292 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01255477 0,16781541 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01255477 0,16688825 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01255477 0,16597128 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 0,000 0,01255477 0,16506433 ! negative chemotaxis GO:0050919 14 5 0,000 0,01255477 0,16416724 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01255477 0,16327985 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01255477 0,16240201 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,01255477 0,16153355 ! behavioral response to pain GO:0048266 9 5 0,000 0,01255477 0,16067432 ! clathrin coat assembly GO:0048268 14 5 0,000 0,01255477 0,1598242 ! Notch receptor processing GO:0007220 8 5 0,000 0,01255477 0,15898302 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01255477 0,15815064 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01255477 0,15732694 ! micturition GO:0060073 9 5 0,000 0,01255477 0,15651178 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01255477 0,15570502 ! copulation GO:0007620 9 5 0,000 0,01255477 0,15490653 ! glial cell fate commitment GO:0021781 13 5 0,000 0,01255477 0,15411619 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,01255477 0,15333387 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01255477 0,15255946 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01255477 0,15179283 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01255477 0,15103387 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,01255477 0,15028245 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01255477 0,14953848 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01255477 0,14880184 ! grooming behavior GO:0007625 6 5 0,000 0,01255477 0,14807242 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01255477 0,14735011 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,01255477 0,14663482 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01255477 0,14592644 ! response to protozoan GO:0001562 10 5 0,000 0,01255477 0,14522487 ! lymph vessel development GO:0001945 10 5 0,000 0,01255477 0,14453001 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,01255477 0,14384178 ! endochondral ossification GO:0001958 16 5 0,000 0,01255477 0,14316006 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01255477 0,14248478 ! parathyroid gland development GO:0060017 13 5 0,000 0,01255477 0,14181584 ! anagen GO:0042640 6 5 0,000 0,01255477 0,14115315 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01255477 0,14049662 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01255477 0,13984617 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 0,000 0,01255477 0,13920172 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,01255477 0,13856318 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,01255477 0,13793047 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,01255477 0,13730351 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,01255477 0,13668223 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,01255477 0,13606655 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,01255477 0,13545638 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01255477 0,13485167 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01255477 0,13425232 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01255477 0,13365829 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,01255477 0,13306948 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,01255477 0,13248585 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01255477 0,13190731 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,01255477 0,1313338 ! negative regulation of survival gene product expression GO:0008634 8 5 0,000 0,01255477 0,13076525 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01255477 0,13020161 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01255477 0,1296428 ! histidine catabolic process GO:0006548 6 5 0,000 0,01255477 0,12908877 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01255477 0,12853946 ! microvillus organization GO:0032528 7 5 0,000 0,01255477 0,1279948 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 10 5 0,000 0,01255477 0,12745474 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,01255477 0,12691921 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01255477 0,12638817 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,01255477 0,12586155 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,01255477 0,12533931 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01255477 0,12482138 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,01255477 0,12430771 ! polyol catabolic process GO:0046174 7 5 0,000 0,01255477 0,12379825 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01255477 0,12329295 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01255477 0,12279176 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01255477 0,12229463 ! muscle cell migration GO:0014812 8 5 0,000 0,01255477 0,1218015 ! mitochondrial fission GO:0000266 8 5 0,000 0,01255477 0,12131234 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,01255477 0,12082709 ! mRNA transcription GO:0009299 9 5 0,000 0,01255477 0,12034571 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,01255477 0,11986815 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,01255477 0,11939436 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,01255477 0,1189243 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01255477 0,11845793 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01255477 0,11799521 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01255477 0,11753608 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01255477 0,11708052 ! response to food GO:0032094 6 5 0,000 0,01255477 0,11662847 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01255477 0,1161799 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01255477 0,11573476 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,01255477 0,11529303 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01255477 0,11485465 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,01255477 0,11441959 ! regulation of phospholipase A2 activity GO:0032429 13 5 0,000 0,01255477 0,11398782 ! forebrain neuron development GO:0021884 13 5 0,000 0,01255477 0,1135593 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01255477 0,11313398 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,01255477 0,11271184 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01255477 0,11229284 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01255477 0,11187694 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01255477 0,11146411 ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,01255477 0,11105431 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01255477 0,11064752 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,01255477 0,1102437 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,01255477 0,10984281 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01255477 0,10944483 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,01255477 0,10904972 ! basic amino acid transport GO:0015802 11 5 0,000 0,01255477 0,10865746 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,01255477 0,108268 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01255477 0,10788133 ! depyrimidination GO:0045008 10 5 0,000 0,01255477 0,10749741 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01255477 0,10711622 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01255477 0,10673771 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01255477 0,10636188 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,01255477 0,10598868 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 7 5 0,000 0,01255477 0,10561809 ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,01255477 0,10525008 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01255477 0,10488463 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01255477 0,10452171 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01255477 0,10416129 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,01255477 0,10380334 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,01255477 0,10344785 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01255477 0,10309479 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01255477 0,10274413 ! response to arsenic GO:0046685 10 5 0,000 0,01255477 0,10239584 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,01255477 0,10204991 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01255477 0,10170631 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,01255477 0,10136501 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,01255477 0,101026 ! response to cadmium ion GO:0046686 7 5 0,000 0,01255477 0,10068924 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,01255477 0,10035473 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,01255477 0,10002243 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01255477 0,09969232 ! decidualization GO:0046697 11 5 0,000 0,01255477 0,09936439 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,01255477 0,0990386 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,01255477 0,09871494 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01255477 0,0983934 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01255477 0,09807394 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,01255477 0,09775655 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01255477 0,0974412 ! neural tube patterning GO:0021532 7 5 0,000 0,01255477 0,09712789 ! embryonic cleavage GO:0040016 6 5 0,000 0,01255477 0,09681658 ! peroxisome fission GO:0016559 5 5 0,000 0,01255477 0,09650726 ! histone demethylation GO:0016577 10 5 0,000 0,01255477 0,09619991 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,01255477 0,09589452 ! mitotic recombination GO:0006312 9 5 0,000 0,01255477 0,09559105 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01255477 0,0952895 ! metaphase plate congression GO:0051310 7 5 0,000 0,01255477 0,09498985 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01255477 0,09469208 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01255477 0,09439617 ! enteric nervous system development GO:0048484 8 5 0,000 0,01255477 0,0941021 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,01255477 0,09380985 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,01255477 0,09351942 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,01255477 0,09323078 ! muscle cell proliferation GO:0033002 11 5 0,000 0,01255477 0,09294392 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01255477 0,09265881 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,01255477 0,09237545 ! plasminogen activation GO:0031639 5 5 0,000 0,01255477 0,09209382 ! B cell homeostasis GO:0001782 13 5 0,000 0,01255477 0,0918139 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,01255477 0,09153568 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01255477 0,09125913 ! metaphase GO:0051323 8 5 0,000 0,01255477 0,09098426 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,01255477 0,09071103 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01255477 0,09043944 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01255477 0,09016947 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01255477 0,08990111 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01255477 0,08963434 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01255477 0,08936915 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,01255477 0,08910553 ! response to redox state GO:0051775 5 5 0,000 0,01255477 0,08884345 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,01255477 0,08858291 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,01255477 0,0883239 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01255477 0,08806639 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,01255477 0,08781039 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01255477 0,08755586 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,01255477 0,08730281 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01255477 0,08705122 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,01255477 0,08680107 ! striatum development GO:0021756 9 5 0,000 0,01255477 0,08655236 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,01255477 0,08630507 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,01255477 0,08605918 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01255477 0,0858147 ! glial cell migration GO:0008347 11 5 0,000 0,01255477 0,0855716 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01255477 0,08532987 ! regulation of mitochondrial depolarization GO:0051900 13 5 0,000 0,01255477 0,0850895 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01255477 0,08485049 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01255477 0,08461281 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01255477 0,08437646 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01255477 0,08414143 ! neuroprotection GO:0043526 6 5 0,000 0,01255477 0,0839077 ! neural plate development GO:0001840 8 5 0,000 0,01255477 0,08367527 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01255477 0,08344412 ! regulation of sensory perception GO:0051931 7 5 0,000 0,01255477 0,08321425 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01255477 0,08298564 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01255477 0,08275828 ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,01255477 0,08253217 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,01255477 0,08230728 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01255477 0,08208362 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01255477 0,08186117 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01255477 0,08163993 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01255477 0,08141987 ! spindle assembly GO:0051225 6 5 0,000 0,01255477 0,081201 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,01255477 0,08098331 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01255477 0,08076677 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01255477 0,08055139 ! drug metabolic process GO:0017144 6 5 0,000 0,01255477 0,08033716 ! stem cell division GO:0017145 11 5 0,000 0,01255477 0,08012407 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01255477 0,0799121 ! organ regeneration GO:0031100 7 5 0,000 0,01255477 0,07970125 ! carnitine metabolic process GO:0009437 7 5 0,000 0,01255477 0,07949151 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,01255477 0,07928287 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01255477 0,07907532 ! negative regulation of kinase activity GO:0033673 131 68 1,000 0,01285595 0,08076085 ! viral reproduction GO:0016032 134 68 1,000 0,01285595 0,08055054 ! cell cycle checkpoint GO:0000075 137 69 1,000 0,01321828 0,08260566 ! cAMP-mediated signaling GO:0019933 120 69 1,000 0,01321828 0,08239166 ! regulation of caspase activity GO:0043281 122 72 1,000 0,01433172 0,08910108 ! negative regulation of transferase activity GO:0051348 140 72 1,000 0,01433172 0,08887144 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01504699 0,093067 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01504699 0,09282837 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,01504699 0,09259095 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01504699 0,09235475 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01504699 0,09211975 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,01504699 0,09188595 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,01504699 0,09165332 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01504699 0,09142188 ! sleep GO:0030431 13 6 0,000 0,01504699 0,09119159 ! response to oxygen radical GO:0000305 11 6 0,000 0,01504699 0,09096247 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,01504699 0,09073449 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,01504699 0,09050766 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,01504699 0,09028195 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,01504699 0,09005737 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01504699 0,0898339 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01504699 0,08961154 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,01504699 0,08939028 ! forebrain regionalization GO:0021871 8 6 0,000 0,01504699 0,08917011 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01504699 0,08895101 ! male meiosis GO:0007140 7 6 0,000 0,01504699 0,088733 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01504699 0,08851605 ! response to zinc ion GO:0010043 9 6 0,000 0,01504699 0,08830015 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01504699 0,08808531 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,01504699 0,08787151 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,01504699 0,08765875 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01504699 0,08744701 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01504699 0,0872363 ! malate metabolic process GO:0006108 11 6 0,000 0,01504699 0,08702659 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,01504699 0,0868179 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,01504699 0,0866102 ! protein refolding GO:0042026 15 6 0,000 0,01504699 0,08640349 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01504699 0,08619777 ! opsonization GO:0008228 8 6 0,000 0,01504699 0,08599302 ! mating behavior GO:0007617 7 6 0,000 0,01504699 0,08578925 ! neuron remodeling GO:0016322 15 6 0,000 0,01504699 0,08558644 ! erythrocyte maturation GO:0043249 7 6 0,000 0,01504699 0,08538458 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,01504699 0,08518368 ! equilibrioception GO:0050957 14 6 0,000 0,01504699 0,08498372 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,01504699 0,08478469 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,01504699 0,0845866 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01504699 0,08438942 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,01504699 0,08419317 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01504699 0,08399783 ! response to interferon-gamma GO:0034341 15 6 0,000 0,01504699 0,08380339 ! toxin metabolic process GO:0009404 11 6 0,000 0,01504699 0,08360985 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01504699 0,0834172 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01504699 0,08322543 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,01504699 0,08303455 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,01504699 0,08284454 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,01504699 0,0826554 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,01504699 0,08246711 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01504699 0,08227969 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,01504699 0,08209311 ! thymic T cell selection GO:0045061 12 6 0,000 0,01504699 0,08190738 ! protein lipoylation GO:0009249 10 6 0,000 0,01504699 0,08172249 ! cysteine metabolic process GO:0006534 10 6 0,000 0,01504699 0,08153843 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01504699 0,0813552 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01504699 0,08117279 ! glutamate catabolic process GO:0006538 10 6 0,000 0,01504699 0,08099119 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,01504699 0,08081041 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01504699 0,08063043 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,01504699 0,08045125 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,01504699 0,08027287 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01504699 0,08009527 ! hyperosmotic response GO:0006972 9 6 0,000 0,01504699 0,07991846 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,01504699 0,07974243 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,01504699 0,07956717 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01504699 0,07939268 ! urea metabolic process GO:0019627 7 6 0,000 0,01504699 0,07921896 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01504699 0,07904599 ! neutrophil activation GO:0042119 8 6 0,000 0,01504699 0,07887378 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01504699 0,07870231 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,01504699 0,07853159 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01504699 0,07836161 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01504699 0,07819236 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01504699 0,07802384 ! neuron apoptosis GO:0051402 9 6 0,000 0,01504699 0,07785605 ! nucleoside salvage GO:0043174 9 6 0,000 0,01504699 0,07768898 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,01504699 0,07752262 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01504699 0,07735697 ! T cell mediated immunity GO:0002456 16 6 0,000 0,01504699 0,07719203 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01504699 0,07702779 GO:0010543|regulation of platelet activation, ! carnitine transport GO:0015879 10 6 0,000 0,01504699 0,07686425 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,01504699 0,0767014 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01504699 0,07653925 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,01504699 0,07637777 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,01504699 0,07621697 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,01504699 0,07605686 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01504699 0,07589741 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,01504699 0,07573863 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,01504699 0,07558051 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,01504699 0,07542305 ! establishment of spindle localization GO:0051293 12 6 0,000 0,01504699 0,07526624 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,01504699 0,07511009 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01504699 0,07495458 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 12 6 0,000 0,01504699 0,07479972 ! neural nucleus development GO:0048857 14 6 0,000 0,01504699 0,07464549 ! response to UV-C GO:0010225 11 6 0,000 0,01504699 0,0744919 ! astrocyte development GO:0014002 15 6 0,000 0,01504699 0,07433894 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,01504699 0,0741866 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01504699 0,07403489 ! interaction with symbiont GO:0051702 13 6 0,000 0,01504699 0,0738838 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01504699 0,07373333 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01504699 0,07358346 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,01504699 0,07343421 ! response to copper ion GO:0046688 10 6 0,000 0,01504699 0,07328555 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,01504699 0,0731375 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,01504699 0,07299005 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01504699 0,07284319 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01504699 0,07269691 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01504699 0,07255123 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,01504699 0,07240613 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01504699 0,0722616 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,01504699 0,07211766 ! hair follicle maturation GO:0048820 7 6 0,000 0,01504699 0,07197428 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01504699 0,07183147 ! Schwann cell development GO:0014044 15 6 0,000 0,01504699 0,07168923 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,01504699 0,07154756 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01504699 0,07140644 ! regulation of myeloid cell apoptosis GO:0033032 13 6 0,000 0,01504699 0,07126587 ! subpallium development GO:0021544 10 6 0,000 0,01504699 0,07112586 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,01504699 0,0709864 ! histone ubiquitination GO:0016574 8 6 0,000 0,01504699 0,07084748 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,01504699 0,07070911 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01504699 0,07057127 ! G2 phase GO:0051319 16 6 0,000 0,01504699 0,07043397 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,01504699 0,07029721 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01504699 0,07016097 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,01504699 0,07002527 ! membrane to membrane docking GO:0022614 14 6 0,000 0,01504699 0,06989008 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01504699 0,06975542 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,01504699 0,06962128 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01504699 0,06948765 ! receptor internalization GO:0031623 10 6 0,000 0,01504699 0,06935453 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,01504699 0,06922192 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,01504699 0,06908982 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01504699 0,06895822 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,01504699 0,06882712 ! protein deubiquitination GO:0016579 14 6 0,000 0,01504699 0,06869651 ! negative regulation of neuroblast proliferation GO:0007406 21 6 0,000 0,01504699 0,06856641 ! protein destabilization GO:0031648 9 6 0,000 0,01504699 0,06843679 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01504699 0,06830767 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,01504699 0,06817903 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01504699 0,06805087 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,01504699 0,0679232 ! progesterone metabolic process GO:0042448 10 6 0,000 0,01504699 0,067796 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,01504699 0,06766928 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,01504699 0,06754303 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,01504699 0,06741725 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,01504699 0,06729194 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01504699 0,06716709 ! determination of adult lifespan GO:0008340 15 6 0,000 0,01504699 0,06704271 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,01504699 0,06691879 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,01504699 0,06679532 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01504699 0,06667231 ! catecholamine transport GO:0051937 9 6 0,000 0,01504699 0,06654975 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,01504699 0,06642764 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01504699 0,06630598 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01504699 0,06618476 ! maternal placenta development GO:0001893 12 6 0,000 0,01504699 0,06606398 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,01504699 0,06594365 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01504699 0,06582375 ! negative regulation of B cell activation GO:0050869 13 6 0,000 0,01504699 0,06570429 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,01504699 0,06558526 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01504699 0,06546666 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,01504699 0,06534849 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,01504699 0,06523074 ! regulation of transcription factor activity GO:0051090 126 74 1,000 0,01509581 0,06532467 GO:0090046|regulation of transcription regulator activity, ! regulation of endopeptidase activity GO:0052548 125 74 1,000 0,01509581 0,06520739 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 1,000 0,01708094 0,07365007 ! regulation of peptidase activity GO:0052547 134 79 1,000 0,01708094 0,07351832 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,01708094 0,07338704 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,01749062 0,07501325 ! tRNA transcription GO:0009304 14 7 0,000 0,01753301 0,07506124 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,01753301 0,07492792 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,01753301 0,07479507 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01753301 0,07466269 ! regulation of helicase activity GO:0051095 15 7 0,000 0,01753301 0,07453077 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,01753301 0,07439933 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,01753301 0,07426834 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01753301 0,07413782 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,01753301 0,07400775 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01753301 0,07387814 ! prostate gland development GO:0030850 13 7 0,000 0,01753301 0,07374898 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,01753301 0,07362028 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01753301 0,07349202 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01753301 0,0733642 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,01753301 0,07323684 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01753301 0,07310991 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,01753301 0,07298342 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,01753301 0,07285737 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,01753301 0,07273175 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,01753301 0,07260657 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01753301 0,07248182 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,01753301 0,07235749 ! glycolipid transport GO:0046836 10 7 0,000 0,01753301 0,07223359 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01753301 0,07211012 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,01753301 0,07198706 ! N-terminal protein amino acid acetylation GO:0006474 13 7 0,000 0,01753301 0,07186443 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,01753301 0,07174221 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,01753301 0,0716204 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01753301 0,07149901 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,01753301 0,07137803 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,01753301 0,07125746 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,01753301 0,0711373 ! mRNA stabilization GO:0048255 18 7 0,000 0,01753301 0,07101754 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 14 7 0,000 0,01753301 0,07089818 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,01753301 0,07077922 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,01753301 0,07066067 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,01753301 0,0705425 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01753301 0,07042474 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01753301 0,07030736 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01753301 0,07019038 ! lipoprotein transport GO:0042953 14 7 0,000 0,01753301 0,07007378 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01753301 0,06995757 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01753301 0,06984175 ! rhythmic behavior GO:0007622 15 7 0,000 0,01753301 0,06972631 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,01753301 0,06961125 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,01753301 0,06949657 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,01753301 0,06938227 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01753301 0,06926834 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,01753301 0,06915478 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01753301 0,0690416 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,01753301 0,06892879 ! mechanosensory behavior GO:0007638 14 7 0,000 0,01753301 0,06881634 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,01753301 0,06870426 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01753301 0,06859255 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,01753301 0,0684812 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01753301 0,06837021 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01753301 0,06825958 ! spinal cord patterning GO:0021511 13 7 0,000 0,01753301 0,0681493 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,01753301 0,06803938 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01753301 0,06792982 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,01753301 0,06782061 ! adrenal gland development GO:0030325 17 7 0,000 0,01753301 0,06771175 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,01753301 0,06760323 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,01753301 0,06749507 ! ovulation GO:0030728 9 7 0,000 0,01753301 0,06738725 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,01753301 0,06727977 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,01753301 0,06717264 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,01753301 0,06706585 ! microtubule nucleation GO:0007020 20 7 0,000 0,01753301 0,06695939 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01753301 0,06685328 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01753301 0,0667475 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,01753301 0,06664205 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,01753301 0,06653694 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,01753301 0,06643215 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01753301 0,0663277 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01753301 0,06622358 ! galactose metabolic process GO:0006012 13 7 0,000 0,01753301 0,06611978 ! vesicle fusion GO:0006906 17 7 0,000 0,01753301 0,0660163 ! response to dietary excess GO:0002021 8 7 0,000 0,01753301 0,06591315 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01753301 0,06581032 ! intracellular pH reduction GO:0051452 11 7 0,000 0,01753301 0,06570782 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01753301 0,06560563 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,01753301 0,06550375 ! organ growth GO:0035265 15 7 0,000 0,01753301 0,0654022 ! purine salvage GO:0043101 10 7 0,000 0,01753301 0,06530096 ! nucleoside transport GO:0015858 8 7 0,000 0,01753301 0,06520003 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,01753301 0,06509941 ! parturition GO:0007567 14 7 0,000 0,01753301 0,0649991 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,01753301 0,0648991 ! rRNA modification GO:0000154 14 7 0,000 0,01753301 0,06479941 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,01753301 0,06470003 ! spindle checkpoint GO:0031577 15 7 0,000 0,01753301 0,06460095 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,01753301 0,06450217 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,01753301 0,06440369 ! macrophage differentiation GO:0030225 11 7 0,000 0,01753301 0,06430551 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01753301 0,06420764 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01753301 0,06411006 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,01753301 0,06401277 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,01753301 0,06391578 ! G1 DNA damage checkpoint GO:0031571 21 7 0,000 0,01753301 0,06381909 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01753301 0,06372269 ! fibrinolysis GO:0042730 10 7 0,000 0,01753301 0,06362657 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 0,000 0,01753301 0,06353075 ! eating behavior GO:0042755 7 7 0,000 0,01753301 0,06343521 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01753301 0,06333997 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01753301 0,063245 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,01753301 0,06315033 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,01753301 0,06305593 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01753301 0,06296182 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,01753301 0,06286798 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01753301 0,06277443 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,01753301 0,06268116 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,01753301 0,06258816 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,01753301 0,06249543 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,01753301 0,06240298 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01753301 0,06231081 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,01753301 0,06221891 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01753301 0,06212727 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01753301 0,06203591 ! regulation of meiosis GO:0040020 12 7 0,000 0,01753301 0,06194481 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,01753301 0,06185398 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01753301 0,06176342 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,01753301 0,06167313 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01753301 0,06158309 ! oxygen homeostasis GO:0032364 12 7 0,000 0,01753301 0,06149332 ! transcription termination GO:0006353 13 7 0,000 0,01753301 0,06140381 ! response to tumor cell GO:0002347 13 7 0,000 0,01753301 0,06131456 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01753301 0,06122557 ! anaphase GO:0051322 17 7 0,000 0,01753301 0,06113684 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,01753301 0,06104836 ! axonal fasciculation GO:0007413 18 7 0,000 0,01753301 0,06096014 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,01753301 0,06087218 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,01753301 0,06078446 ! peptidyl-threonine modification GO:0018210 25 7 0,000 0,01753301 0,060697 ! diuresis GO:0030146 12 7 0,000 0,01753301 0,0606098 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01753301 0,06052284 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01753301 0,06043613 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01753301 0,06034967 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,01753301 0,06026345 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,01753301 0,06017749 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01753301 0,06009176 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01753301 0,06000628 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01753301 0,05992105 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01753301 0,05983605 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,01753301 0,0597513 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01753301 0,05966679 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,01753301 0,05958251 GO:0046479|glycosphingolipid catabolic process, ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01753301 0,05949847 ! lymph node development GO:0048535 10 7 0,000 0,01753301 0,05941467 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,01753301 0,05933111 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01753301 0,05924778 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,01753301 0,05916468 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,01753301 0,05908182 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,01753301 0,05899919 ! adult feeding behavior GO:0008343 9 7 0,000 0,01753301 0,05891678 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,01753301 0,05883461 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,01753301 0,05875267 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01753301 0,05867096 ! muscle adaptation GO:0043500 14 7 0,000 0,01753301 0,05858947 ! embryonic heart tube development GO:0035050 10 7 0,000 0,01753301 0,05850821 ! retina homeostasis GO:0001895 12 7 0,000 0,01753301 0,05842717 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,01753301 0,05834636 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,01753301 0,05826577 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,01753301 0,0581854 ! protein prenylation GO:0018342 18 7 0,000 0,01753301 0,05810526 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,01753301 0,05802533 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,01753301 0,05794563 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01753301 0,05786614 ! regulation of neuron differentiation GO:0045664 167 81 1,000 0,01790446 0,05901115 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,01832245 0,06030617 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,01832245 0,06022378 ! regulation of lyase activity GO:0051339 160 83 1,000 0,01874455 0,06152713 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,01917075 0,06284035 ! negative regulation of transport GO:0051051 153 84 1,000 0,01917075 0,06275485 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,01917075 0,06266959 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,02001283 0,06533361 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,02001283 0,06524509 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 0,000 0,02001283 0,0651568 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,02001283 0,06506875 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,02001283 0,06498094 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,02001283 0,06489336 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02001283 0,06480602 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02001283 0,06471892 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,02001283 0,06463204 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,02001283 0,06454541 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,02001283 0,064459 ! meiotic prophase I GO:0007128 13 8 0,000 0,02001283 0,06437283 ! oligopeptide transport GO:0006857 15 8 0,000 0,02001283 0,06428688 ! UTP metabolic process GO:0046051 8 8 0,000 0,02001283 0,06420116 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,02001283 0,06411568 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,02001283 0,06403042 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,02001283 0,06394538 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02001283 0,06386057 ! succinate metabolic process GO:0006105 14 8 0,000 0,02001283 0,06377599 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02001283 0,06369163 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02001283 0,06360749 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,02001283 0,06352358 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,02001283 0,06343989 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,02001283 0,06335641 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02001283 0,06327316 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02001283 0,06319012 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,02001283 0,0631073 ! reflex GO:0060004 16 8 0,000 0,02001283 0,0630247 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,02001283 0,06294232 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,02001283 0,06286015 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02001283 0,06277819 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,02001283 0,06269645 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,02001283 0,06261492 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,02001283 0,0625336 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02001283 0,06245249 ! pigment granule organization GO:0048753 16 8 0,000 0,02001283 0,0623716 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02001283 0,06229091 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,02001283 0,06221043 ! astrocyte differentiation GO:0048708 18 8 0,000 0,02001283 0,06213016 ! histidine metabolic process GO:0006547 16 8 0,000 0,02001283 0,06205009 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02001283 0,06197024 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,02001283 0,06189058 ! glycine catabolic process GO:0006546 13 8 0,000 0,02001283 0,06181113 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,02001283 0,06173189 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,02001283 0,06165285 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,02001283 0,06157401 ! regulation of pigmentation during development GO:0048070 24 8 0,000 0,02001283 0,06149537 ! melanin metabolic process GO:0006582 15 8 0,000 0,02001283 0,06141693 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,02001283 0,06133869 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02001283 0,06126065 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,02001283 0,06118281 ! macrophage activation GO:0042116 12 8 0,000 0,02001283 0,06110517 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02001283 0,06102772 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02001283 0,06095047 ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,02001283 0,06087342 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02001283 0,06079656 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,02001283 0,06071989 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,02001283 0,06064342 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02001283 0,06056714 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,02001283 0,06049105 ! osteoblast development GO:0002076 16 8 0,000 0,02001283 0,06041515 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,02001283 0,06033944 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,02001283 0,06026392 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,02001283 0,06018859 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,02001283 0,06011345 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,02001283 0,0600385 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02001283 0,05996373 ! response to UV-B GO:0010224 16 8 0,000 0,02001283 0,05988915 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,02001283 0,05981475 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02001283 0,05974054 ! intermediate filament organization GO:0045109 12 8 0,000 0,02001283 0,05966651 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,02001283 0,05959267 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,02001283 0,059519 ! cellular extravasation GO:0045123 12 8 0,000 0,02001283 0,05944552 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,02001283 0,05937222 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,02001283 0,05929911 ! response to antibiotic GO:0046677 11 8 0,000 0,02001283 0,05922617 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,02001283 0,05915341 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,02001283 0,05908083 ! DNA topological change GO:0006265 12 8 0,000 0,02001283 0,05900842 ! response to tropane GO:0014073 15 8 0,000 0,02001283 0,0589362 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,02001283 0,05886415 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 0,000 0,02001283 0,05879228 ! melanosome transport GO:0032402 13 8 0,000 0,02001283 0,05872058 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,02001283 0,05864905 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02001283 0,0585777 ! mast cell activation GO:0045576 14 8 0,000 0,02001283 0,05850653 ! multicellular organismal aging GO:0010259 18 8 0,000 0,02001283 0,05843553 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,02001283 0,0583647 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,02001283 0,05829404 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,02001283 0,05822355 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02001283 0,05815323 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02001283 0,05808308 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,02001283 0,0580131 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02001283 0,05794329 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02001283 0,05787365 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,02001283 0,05780417 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,02001283 0,05773486 ! intracellular lipid transport GO:0032365 13 8 0,000 0,02001283 0,05766572 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02001283 0,05759674 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02001283 0,05752793 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,02001283 0,05745928 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,02001283 0,05739079 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02001283 0,05732247 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,02001283 0,05725431 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,02001283 0,05718631 ! hormone catabolic process GO:0042447 17 8 0,000 0,02001283 0,05711847 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02001283 0,0570508 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,02001283 0,05698328 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,02001283 0,05691593 ! ATP catabolic process GO:0006200 11 8 0,000 0,02001283 0,05684873 ! blastocyst growth GO:0001832 19 8 0,000 0,02001283 0,05678169 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02001283 0,05671481 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02001283 0,05664809 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,02001283 0,05658152 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02001283 0,05651511 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02001283 0,05644886 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,02001283 0,05638276 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,02001283 0,05631681 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,02001283 0,05625102 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,02001283 0,05618538 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,02001283 0,0561199 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,02001283 0,05605457 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02001283 0,05598939 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,02001283 0,05592436 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02001283 0,05585948 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02001283 0,05579475 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,02001283 0,05573018 ! NAD biosynthetic process GO:0009435 13 8 0,000 0,02001283 0,05566575 ! tube morphogenesis GO:0035239 176 86 1,000 0,02003533 0,05566399 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,02047368 0,05681623 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of DNA binding GO:0051101 155 88 1,000 0,02091603 0,05797692 ! regulation of neurological system process GO:0031644 148 88 1,000 0,02091603 0,0579102 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,02181265 0,06032326 ! axon extension GO:0048675 15 9 0,000 0,02248648 0,06211535 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,02248648 0,06204411 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,02248648 0,06197304 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,02248648 0,06190214 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02248648 0,06183139 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,02248648 0,06176081 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,02248648 0,06169038 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,02248648 0,06162012 ! phosphate transport GO:0006817 19 9 0,000 0,02248648 0,06155002 ! reproductive behavior GO:0019098 19 9 0,000 0,02248648 0,06148008 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02248648 0,06141029 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,02248648 0,06134067 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02248648 0,0612712 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,02248648 0,06120189 ! GTP metabolic process GO:0046039 9 9 0,000 0,02248648 0,06113273 ! RNA methylation GO:0001510 15 9 0,000 0,02248648 0,06106373 ! elastic fiber assembly GO:0048251 15 9 0,000 0,02248648 0,06099489 ! induction of positive chemotaxis GO:0050930 15 9 0,000 0,02248648 0,0609262 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,02248648 0,06085767 ! artery development GO:0060840 24 9 0,000 0,02248648 0,06078929 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,02248648 0,06072106 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,02248648 0,06065299 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,02248648 0,06058507 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,02248648 0,0605173 ! chemosensory behavior GO:0007635 20 9 0,000 0,02248648 0,06044968 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02248648 0,06038222 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,02248648 0,0603149 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02248648 0,06024774 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,02248648 0,06018072 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,02248648 0,06011385 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,02248648 0,06004713 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02248648 0,05998056 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02248648 0,05991414 ! protein targeting to ER GO:0045047 22 9 0,000 0,02248648 0,05984786 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,02248648 0,05978173 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,02248648 0,05971575 ! T cell selection GO:0045058 23 9 0,000 0,02248648 0,05964991 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,02248648 0,05958421 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02248648 0,05951867 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,02248648 0,05945326 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02248648 0,059388 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02248648 0,05932288 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02248648 0,0592579 ! mannose metabolic process GO:0006013 13 9 0,000 0,02248648 0,05919307 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,02248648 0,05912838 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,02248648 0,05906383 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,02248648 0,05899942 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,02248648 0,05893515 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02248648 0,05887102 ! ruffle organization GO:0031529 15 9 0,000 0,02248648 0,05880703 ! retinol metabolic process GO:0042572 18 9 0,000 0,02248648 0,05874318 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,02248648 0,05867947 ! behavioral fear response GO:0001662 22 9 0,000 0,02248648 0,05861589 GO:0002209|behavioral defense response, ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,02248648 0,05855245 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,02248648 0,05848915 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,02248648 0,05842599 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 16 9 0,000 0,02248648 0,05836296 ! oligodendrocyte development GO:0014003 10 9 0,000 0,02248648 0,05830007 ! alpha-beta T cell differentiation GO:0046632 21 9 0,000 0,02248648 0,05823732 ! segment specification GO:0007379 13 9 0,000 0,02248648 0,0581747 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02248648 0,05811221 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,02248648 0,05804986 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02248648 0,05798764 ! response to amine stimulus GO:0014075 13 9 0,000 0,02248648 0,05792555 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02248648 0,0578636 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,02248648 0,05780178 ! erythrocyte development GO:0048821 15 9 0,000 0,02248648 0,05774009 ! gas homeostasis GO:0033483 16 9 0,000 0,02248648 0,05767854 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02248648 0,05761711 ! regulation of mitochondrial membrane potential GO:0051881 17 9 0,000 0,02248648 0,05755582 ! renal water homeostasis GO:0003091 14 9 0,000 0,02248648 0,05749465 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,02248648 0,05743362 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,02248648 0,05737271 ! icosanoid secretion GO:0032309 15 9 0,000 0,02248648 0,05731194 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,02248648 0,05725129 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02248648 0,05719077 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,02248648 0,05713038 ! regulation of cell division GO:0051302 15 9 0,000 0,02248648 0,05707011 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,02248648 0,05700998 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,02248648 0,05694997 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02248648 0,05689008 ! sterol catabolic process GO:0016127 11 9 0,000 0,02248648 0,05683032 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02248648 0,05677069 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,02248648 0,05671118 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,02248648 0,0566518 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,02248648 0,05659254 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,02248648 0,0565334 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,02248648 0,05647439 ! musculoskeletal movement GO:0050881 14 9 0,000 0,02248648 0,0564155 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,02248648 0,05635674 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,02248648 0,05629809 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02248648 0,05623957 ! purine base metabolic process GO:0006144 21 9 0,000 0,02248648 0,05618117 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,02248648 0,05612289 ! pigment granule transport GO:0051904 17 9 0,000 0,02248648 0,05606473 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,02248648 0,05600669 ! regulation of telomere maintenance GO:0032204 14 9 0,000 0,02248648 0,05594878 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,02248648 0,05589098 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02248648 0,0558333 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02248648 0,05577574 ! mitochondrion localization GO:0051646 15 9 0,000 0,02248648 0,0557183 ! positive regulation of MAP kinase activity GO:0043406 160 93 1,000 0,02318706 0,05739512 ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,02318706 0,05733614 ! female pregnancy GO:0007565 164 94 1,000 0,02365297 0,05842817 ! regulation of Rho protein signal transduction GO:0035023 213 95 1,000 0,02412272 0,05952745 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,02495396 0,06151561 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 0,000 0,02495396 0,06145265 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02495396 0,06138981 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,02495396 0,0613271 ! positive regulation of B cell proliferation GO:0030890 16 10 0,000 0,02495396 0,06126453 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02495396 0,06120207 ! synapsis GO:0007129 13 10 0,000 0,02495396 0,06113975 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,02495396 0,06107755 ! N-glycan processing GO:0006491 20 10 0,000 0,02495396 0,06101548 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,02495396 0,06095354 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,02495396 0,06089172 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02495396 0,06083003 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,02495396 0,06076846 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,02495396 0,06070701 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,02495396 0,06064569 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,02495396 0,0605845 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,02495396 0,06052342 ! androgen metabolic process GO:0008209 17 10 0,000 0,02495396 0,06046247 ! phospholipid efflux GO:0033700 16 10 0,000 0,02495396 0,06040165 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02495396 0,06034094 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,02495396 0,06028036 ! lung alveolus development GO:0048286 26 10 0,000 0,02495396 0,06021989 ! pathogenesis GO:0009405 13 10 0,000 0,02495396 0,06015955 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02495396 0,06009933 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,02495396 0,06003924 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,02495396 0,05997926 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,02495396 0,0599194 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,02495396 0,05985966 ! endoderm development GO:0007492 16 10 0,000 0,02495396 0,05980004 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,02495396 0,05974053 ! arginine catabolic process GO:0006527 13 10 0,000 0,02495396 0,05968115 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02495396 0,05962188 ! proline metabolic process GO:0006560 13 10 0,000 0,02495396 0,05956273 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02495396 0,0595037 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,02495396 0,05944479 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,02495396 0,05938599 ! V(D)J recombination GO:0033151 28 10 0,000 0,02495396 0,05932731 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02495396 0,05926874 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,02495396 0,05921029 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,02495396 0,05915196 ! B cell proliferation GO:0042100 18 10 0,000 0,02495396 0,05909374 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,02495396 0,05903563 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,02495396 0,05897764 ! multicellular organism growth GO:0035264 18 10 0,000 0,02495396 0,05891976 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,02495396 0,058862 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,02495396 0,05880434 ! epithelial cell development GO:0002064 20 10 0,000 0,02495396 0,05874681 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,02495396 0,05868938 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02495396 0,05863207 ! macroautophagy GO:0016236 17 10 0,000 0,02495396 0,05857486 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,02495396 0,05851777 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,02495396 0,05846079 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,02495396 0,05840393 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,02495396 0,05834717 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 0,000 0,02495396 0,05829052 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02495396 0,05823398 ! regulation of bone resorption GO:0045124 25 10 0,000 0,02495396 0,05817755 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02495396 0,05812123 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02495396 0,05806502 ! alpha-beta T cell activation GO:0046631 23 10 0,000 0,02495396 0,05800892 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,02495396 0,05795293 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,02495396 0,05789704 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 0,000 0,02495396 0,05784127 ! blastoderm segmentation GO:0007350 18 10 0,000 0,02495396 0,0577856 ! response to dsRNA GO:0043331 20 10 0,000 0,02495396 0,05773003 ! DNA ligation GO:0006266 19 10 0,000 0,02495396 0,05767458 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02495396 0,05761923 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02495396 0,05756398 ! melanosome localization GO:0032400 16 10 0,000 0,02495396 0,05750885 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,02495396 0,05745381 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,02495396 0,05739889 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,02495396 0,05734406 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02495396 0,05728935 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,02495396 0,05723473 ! mRNA cleavage GO:0006379 17 10 0,000 0,02495396 0,05718022 ! protein sumoylation GO:0016925 15 10 0,000 0,02495396 0,05712582 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02495396 0,05707152 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02495396 0,05701732 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02495396 0,05696322 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,02495396 0,05690923 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,02495396 0,05685534 ! salivary gland development GO:0007431 27 10 0,000 0,02495396 0,05680155 ! prophase GO:0051324 15 10 0,000 0,02495396 0,05674786 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02495396 0,05669427 ! apical protein localization GO:0045176 15 10 0,000 0,02495396 0,05664079 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,02495396 0,0565874 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,02495396 0,05653412 ! positive regulation of leukocyte migration GO:0002687 25 10 0,000 0,02495396 0,05648094 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02495396 0,05642785 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,02495396 0,05637487 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,02495396 0,05632198 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,02495396 0,0562692 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02495396 0,05621651 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02495396 0,05616392 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,02495396 0,05611143 ! detection of calcium ion GO:0005513 23 10 0,000 0,02495396 0,05605904 ! oocyte development GO:0048599 17 10 0,000 0,02495396 0,05600675 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02495396 0,05595455 ! blastocyst formation GO:0001825 17 10 0,000 0,02495396 0,05590245 ! cerebellar cortex development GO:0021695 15 10 0,000 0,02495396 0,05585045 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,02495396 0,05579855 ! activation of innate immune response GO:0002218 12 10 0,000 0,02495396 0,05574674 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,02495396 0,05569502 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,02495396 0,05564341 ! response to nicotine GO:0035094 20 10 0,000 0,02495396 0,05559188 ! establishment of cell polarity GO:0030010 16 10 0,000 0,02495396 0,05554046 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,02495396 0,05548913 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,02495396 0,05543789 ! localization within membrane GO:0051668 20 10 0,000 0,02495396 0,05538675 ! regulation of DNA metabolic process GO:0051052 178 97 1,000 0,02507369 0,0556012 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 1,000 0,0260398 0,05769039 ! cell cycle arrest GO:0007050 213 100 1,000 0,02652848 0,05871897 ! negative regulation of muscle development GO:0048635 20 11 0,000 0,0274153 0,06062612 ! respiratory burst GO:0045730 17 11 0,000 0,0274153 0,06057044 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,0274153 0,06051488 ! neuron fate specification GO:0048665 17 11 0,000 0,0274153 0,06045941 ! telencephalon cell migration GO:0022029 20 11 0,000 0,0274153 0,06040404 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,0274153 0,06034878 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,0274153 0,06029361 ! thyroid gland development GO:0030878 26 11 0,000 0,0274153 0,06023855 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 0,000 0,0274153 0,06018359 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,0274153 0,06012873 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,0274153 0,06007397 ! response to pain GO:0048265 24 11 0,000 0,0274153 0,0600193 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,0274153 0,05996474 ! T cell proliferation GO:0042098 26 11 0,000 0,0274153 0,05991028 ! blood vessel remodeling GO:0001974 29 11 0,000 0,0274153 0,05985591 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 0,000 0,0274153 0,05980164 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 22 11 0,000 0,0274153 0,05974748 ! bone resorption GO:0045453 16 11 0,000 0,0274153 0,05969341 ! peptide or protein amino-terminal blocking GO:0018409 21 11 0,000 0,0274153 0,05963943 ! ventral spinal cord development GO:0021517 21 11 0,000 0,0274153 0,05958556 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,0274153 0,05953178 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,0274153 0,0594781 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,0274153 0,05942452 ! melanocyte differentiation GO:0030318 21 11 0,000 0,0274153 0,05937103 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,0274153 0,05931764 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,0274153 0,05926434 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,0274153 0,05921114 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,0274153 0,05915804 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,0274153 0,05910503 ! lipid digestion GO:0044241 18 11 0,000 0,0274153 0,05905212 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,0274153 0,0589993 ! UV protection GO:0009650 19 11 0,000 0,0274153 0,05894657 ! adult heart development GO:0007512 14 11 0,000 0,0274153 0,05889394 ! chondrocyte differentiation GO:0002062 24 11 0,000 0,0274153 0,0588414 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,0274153 0,05878896 ! temperature homeostasis GO:0001659 17 11 0,000 0,0274153 0,05873661 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,0274153 0,05868435 ! negative regulation of ossification GO:0030279 26 11 0,000 0,0274153 0,05863219 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,0274153 0,05858012 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,0274153 0,05852814 ! regulation of organ growth GO:0046620 13 11 0,000 0,0274153 0,05847625 ! pigment granule localization GO:0051875 20 11 0,000 0,0274153 0,05842446 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,0274153 0,05837276 ! vasoconstriction GO:0042310 18 11 0,000 0,0274153 0,05832114 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,0274153 0,05826962 ! embryonic axis specification GO:0000578 18 11 0,000 0,0274153 0,05821819 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,0274153 0,05816686 ! snRNA metabolic process GO:0016073 24 11 0,000 0,0274153 0,05811561 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,0274153 0,05806445 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,0274153 0,05801338 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,0274153 0,0579624 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,0274153 0,05791151 ! zymogen activation GO:0031638 15 11 0,000 0,0274153 0,05786071 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,0274153 0,05781 ! neuroblast proliferation GO:0007405 24 11 0,000 0,0274153 0,05775938 ! nucleosome positioning GO:0016584 15 11 0,000 0,0274153 0,05770885 ! regulation of isotype switching GO:0045191 22 11 0,000 0,0274153 0,0576584 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,0274153 0,05760805 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,0274153 0,05755778 ! regulation of leukocyte migration GO:0002685 26 11 0,000 0,0274153 0,0575076 ! acid secretion GO:0046717 18 11 0,000 0,0274153 0,0574575 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,0274153 0,0574075 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,0274153 0,05735758 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,0274153 0,05730774 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,0274153 0,057258 ! oocyte differentiation GO:0009994 18 11 0,000 0,0274153 0,05720834 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,0274153 0,05715876 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 0,000 0,0274153 0,05710928 ! cholesterol efflux GO:0033344 19 11 0,000 0,0274153 0,05705987 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,0274153 0,05701056 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,0274153 0,05696132 ! negative regulation of glucose import GO:0046325 17 11 0,000 0,0274153 0,05691218 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 25 11 0,000 0,0274153 0,05686312 ! embryonic gut development GO:0048566 15 11 0,000 0,0274153 0,05681414 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,0274153 0,05676524 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,0274153 0,05671644 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,0274153 0,05666771 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,0274153 0,05661907 ! defense response to fungus GO:0050832 13 11 0,000 0,0274153 0,05657051 ! developmental induction GO:0031128 19 11 0,000 0,0274153 0,05652203 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,0274153 0,05647364 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,0274153 0,05642533 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,0274153 0,05637711 ! sequestering of metal ion GO:0051238 14 11 0,000 0,0274153 0,05632896 ! lamellipodium assembly GO:0030032 20 11 0,000 0,0274153 0,0562809 ! nucleus localization GO:0051647 19 11 0,000 0,0274153 0,05623292 ! regulation of synapse organization GO:0050807 17 11 0,000 0,0274153 0,05618502 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,02987051 0,06116463 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,02987051 0,06111262 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,02987051 0,0610607 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,02987051 0,06100886 ! regulation of B cell proliferation GO:0030888 20 12 0,000 0,02987051 0,06095712 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,02987051 0,06090546 ! cartilage condensation GO:0001502 20 12 0,000 0,02987051 0,06085389 ! regulation of positive chemotaxis GO:0050926 19 12 0,000 0,02987051 0,0608024 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,02987051 0,06075101 ! protein complex disassembly GO:0043241 27 12 0,000 0,02987051 0,0606997 GO:0043624|cellular protein complex disassembly, ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,02987051 0,06064847 ! hippocampus development GO:0021766 26 12 0,000 0,02987051 0,06059734 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,02987051 0,06054628 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,02987051 0,06049532 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,02987051 0,06044444 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,02987051 0,06039365 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,02987051 0,06034294 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,02987051 0,06029232 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,02987051 0,06024178 ! drug transport GO:0015893 16 12 0,000 0,02987051 0,06019132 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,02987051 0,06014095 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,02987051 0,06009067 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,02987051 0,06004047 ! polyamine metabolic process GO:0006595 17 12 0,000 0,02987051 0,05999035 ! focal adhesion formation GO:0048041 35 12 0,000 0,02987051 0,05994032 ! mitotic spindle organization GO:0007052 21 12 0,000 0,02987051 0,05989037 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,02987051 0,0598405 ! forebrain cell migration GO:0021885 21 12 0,000 0,02987051 0,05979072 ! asymmetric protein localization GO:0008105 20 12 0,000 0,02987051 0,05974101 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,02987051 0,0596914 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,02987051 0,05964186 ! entry into host cell GO:0030260 32 12 0,000 0,02987051 0,0595924 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 26 12 0,000 0,02987051 0,05954303 ! monoamine transport GO:0015844 18 12 0,000 0,02987051 0,05949374 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02987051 0,05944453 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,02987051 0,05939541 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,02987051 0,05934636 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,02987051 0,05929739 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,02987051 0,05924851 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,02987051 0,0591997 ! protein homotetramerization GO:0051289 21 12 0,000 0,02987051 0,05915098 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,02987051 0,05910234 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,02987051 0,05905377 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,02987051 0,05900529 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,02987051 0,05895688 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,02987051 0,05890856 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,02987051 0,05886031 ! cranial nerve development GO:0021545 20 12 0,000 0,02987051 0,05881214 ! fucose catabolic process GO:0019317 22 12 0,000 0,02987051 0,05876406 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,02987051 0,05871605 ! histone acetylation GO:0016573 26 12 0,000 0,02987051 0,05866811 ! histone methylation GO:0016571 26 12 0,000 0,02987051 0,05862026 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,02987051 0,05857249 ! autonomic nervous system development GO:0048483 24 12 0,000 0,02987051 0,05852479 ! gland morphogenesis GO:0022612 29 12 0,000 0,02987051 0,05847717 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,02987051 0,05842963 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,02987051 0,05838216 ! T cell homeostasis GO:0043029 25 12 0,000 0,02987051 0,05833477 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,02987051 0,05828746 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,02987051 0,05824023 ! spleen development GO:0048536 22 12 0,000 0,02987051 0,05819307 ! digestive tract morphogenesis GO:0048546 26 12 0,000 0,02987051 0,05814599 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,02987051 0,05809898 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,02987051 0,05805205 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,02987051 0,0580052 ! negative regulation of mast cell proliferation GO:0070667 23 12 0,000 0,02987051 0,05795842 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 0,000 0,02987051 0,05791172 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,02987051 0,05786509 ! response to cold GO:0009409 17 12 0,000 0,02987051 0,05781854 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,02987051 0,05777206 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,02987051 0,05772565 ! cGMP metabolic process GO:0046068 18 13 0,000 0,0323196 0,06240847 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,0323196 0,06235842 ! regulation of chemokine production GO:0032642 18 13 0,000 0,0323196 0,06230845 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,0323196 0,06225857 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,0323196 0,06220876 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,0323196 0,06215903 ! lipid localization GO:0010876 28 13 0,000 0,0323196 0,06210938 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,0323196 0,06205982 ! organelle fusion GO:0048284 32 13 0,000 0,0323196 0,06201033 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,0323196 0,06196092 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,0323196 0,06191158 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,0323196 0,06186233 ! endocrine pancreas development GO:0031018 22 13 0,000 0,0323196 0,06181316 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,0323196 0,06176406 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,0323196 0,06171504 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,0323196 0,0616661 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,0323196 0,06161723 ! methionine metabolic process GO:0006555 27 13 0,000 0,0323196 0,06156845 ! plasma membrane organization GO:0007009 24 13 0,000 0,0323196 0,06151974 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,0323196 0,06147111 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,0323196 0,06142255 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,0323196 0,06137407 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,0323196 0,06132567 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,0323196 0,06127734 ! response to X-ray GO:0010165 25 13 0,000 0,0323196 0,06122909 ! cytokine metabolic process GO:0042107 22 13 0,000 0,0323196 0,06118092 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,0323196 0,06113282 ! exocrine system development GO:0035272 32 13 0,000 0,0323196 0,0610848 ! negative regulation of mitotic cell cycle GO:0045930 33 13 0,000 0,0323196 0,06103685 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,0323196 0,06098898 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,0323196 0,06094118 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,0323196 0,06089346 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,0323196 0,06084581 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,0323196 0,06079824 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,0323196 0,06075074 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,0323196 0,06070332 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,0323196 0,06065597 ! regulation of cellular pH GO:0030641 22 13 0,000 0,0323196 0,06060869 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,0323196 0,06056149 ! ribosome assembly GO:0042255 17 13 0,000 0,0323196 0,06051436 ! regulation of monooxygenase activity GO:0032768 33 13 0,000 0,0323196 0,0604673 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,0323196 0,06042032 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,0323196 0,06037341 ! chromatin silencing GO:0006342 26 13 0,000 0,0323196 0,06032657 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,0323196 0,06027981 ! regulation of epidermis development GO:0045682 19 13 0,000 0,0323196 0,06023311 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0323196 0,06018649 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,0323196 0,06013995 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,0323196 0,06009347 ! regulation of mRNA stability GO:0043488 31 13 0,000 0,0323196 0,06004707 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,0323196 0,06000073 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,0323196 0,05995447 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,0323196 0,05990828 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,0323196 0,05986216 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,0323196 0,05981612 ! embryonic placenta development GO:0001892 23 13 0,000 0,0323196 0,05977014 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,0323196 0,05972423 ! insulin secretion GO:0030073 23 13 0,000 0,0323196 0,0596784 ! actin filament polymerization GO:0030041 24 13 0,000 0,0323196 0,05963263 ! acrosome reaction GO:0007340 18 13 0,000 0,0323196 0,05958693 ! rRNA transcription GO:0009303 25 14 0,000 0,03476258 0,06404194 ! lactation GO:0007595 26 14 0,000 0,03476258 0,06399294 ! N-terminal protein amino acid modification GO:0031365 27 14 0,000 0,03476258 0,06394402 ! reproductive cellular process GO:0048610 20 14 0,000 0,03476258 0,06389517 ! tRNA modification GO:0006400 20 14 0,000 0,03476258 0,0638464 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,03476258 0,0637977 ! regulation of S phase GO:0033261 23 14 0,000 0,03476258 0,06374907 ! water transport GO:0006833 21 14 0,000 0,03476258 0,06370052 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,03476258 0,06365204 ! non-recombinational repair GO:0000726 25 14 0,000 0,03476258 0,06360363 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,03476258 0,0635553 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,03476258 0,06350705 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,03476258 0,06345886 ! hair follicle morphogenesis GO:0031069 26 14 0,000 0,03476258 0,06341075 ! RNA polyadenylation GO:0043631 30 14 0,000 0,03476258 0,06336271 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,03476258 0,06331475 ! palate development GO:0060021 31 14 0,000 0,03476258 0,06326685 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 0,000 0,03476258 0,06321903 ! regulated secretory pathway GO:0045055 23 14 0,000 0,03476258 0,06317128 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,03476258 0,06312361 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,03476258 0,063076 ! arginine metabolic process GO:0006525 17 14 0,000 0,03476258 0,06302847 ! regulation of heart rate GO:0002027 24 14 0,000 0,03476258 0,06298101 ! organic alcohol transport GO:0015850 29 14 0,000 0,03476258 0,06293362 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,03476258 0,0628863 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 0,000 0,03476258 0,06283905 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,03476258 0,06279188 ! neutral amino acid transport GO:0015804 26 14 0,000 0,03476258 0,06274477 ! L-amino acid transport GO:0015807 30 14 0,000 0,03476258 0,06269774 ! bone mineralization GO:0030282 17 14 0,000 0,03476258 0,06265077 ! stem cell development GO:0048864 43 14 0,000 0,03476258 0,06260388 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,03476258 0,06255705 ! T cell differentiation in the thymus GO:0033077 31 14 0,000 0,03476258 0,0625103 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03476258 0,06246361 ! cerebellum development GO:0021549 21 14 0,000 0,03476258 0,062417 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,03476258 0,06237045 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,03476258 0,06232398 ! response to gamma radiation GO:0010332 28 14 0,000 0,03476258 0,06227757 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,03476258 0,06223123 ! cofactor transport GO:0051181 26 14 0,000 0,03476258 0,06218497 ! NADP metabolic process GO:0006739 24 14 0,000 0,03476258 0,06213877 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,03476258 0,06209263 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,03476258 0,06204657 ! intestinal absorption GO:0050892 25 14 0,000 0,03476258 0,06200058 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,03476258 0,06195465 ! oxygen transport GO:0015671 21 14 0,000 0,03476258 0,06190879 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,03476258 0,061863 ! male genitalia development GO:0030539 24 14 0,000 0,03476258 0,06181728 ! regulation of RNA stability GO:0043487 32 14 0,000 0,03476258 0,06177162 ! regulation of axon extension GO:0030516 37 14 0,000 0,03476258 0,06172604 ! release of cytochrome c from mitochondria GO:0001836 30 14 0,000 0,03476258 0,06168052 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,03476258 0,06163506 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,03719949 0,06590719 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,03719949 0,06585869 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,03719949 0,06581027 ! superoxide anion generation GO:0042554 20 15 0,000 0,03719949 0,06576191 ! negative regulation of bone remodeling GO:0046851 33 15 0,000 0,03719949 0,06571363 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,03719949 0,06566542 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,03719949 0,06561728 ! copper ion transport GO:0006825 20 15 0,000 0,03719949 0,0655692 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,03719949 0,0655212 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,03719949 0,06547327 ! sulfate transport GO:0008272 23 15 0,000 0,03719949 0,06542541 ! response to cAMP GO:0051591 22 15 0,000 0,03719949 0,06537762 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,03719949 0,0653299 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,03719949 0,06528225 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,03719949 0,06523467 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,03719949 0,06518715 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,03719949 0,06513971 ! response to hexose stimulus GO:0009746 22 15 0,000 0,03719949 0,06509234 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,03719949 0,06504503 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,03719949 0,06499779 ! pituitary gland development GO:0021983 29 15 0,000 0,03719949 0,06495063 ! vesicle coating GO:0006901 33 15 0,000 0,03719949 0,06490353 ! regulation of the force of heart contraction GO:0002026 26 15 0,000 0,03719949 0,0648565 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,03719949 0,06480953 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,03719949 0,06476264 ! regulation of exocytosis GO:0017157 22 15 0,000 0,03719949 0,06471581 ! G1/S transition checkpoint GO:0031575 40 15 0,000 0,03719949 0,06466905 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,03719949 0,06462236 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,03719949 0,06457573 ! regulation of vasodilation GO:0042312 26 15 0,000 0,03719949 0,06452917 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,03719949 0,06448268 ! histone deacetylation GO:0016575 20 15 0,000 0,03719949 0,06443626 ! mRNA splice site selection GO:0006376 38 15 0,000 0,03719949 0,0643899 ! tissue regeneration GO:0042246 26 15 0,000 0,03719949 0,06434361 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,03719949 0,06429739 ! water homeostasis GO:0030104 27 15 0,000 0,03719949 0,06425123 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,03719949 0,06420514 ! muscle maintenance GO:0046716 26 15 0,000 0,03719949 0,06415911 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,03719949 0,06411315 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,03719949 0,06406726 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,03719949 0,06402143 ! dopamine metabolic process GO:0042417 35 15 0,000 0,03719949 0,06397567 ! heme biosynthetic process GO:0006783 29 15 0,000 0,03719949 0,06392997 ! cell killing GO:0001906 29 15 0,000 0,03719949 0,06388434 ! lymphocyte homeostasis GO:0002260 30 15 0,000 0,03719949 0,06383878 ! detection of bacterium GO:0016045 18 15 0,000 0,03719949 0,06379327 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,03719949 0,06374784 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,03719949 0,06370247 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,03719949 0,06365716 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,03719949 0,06361191 ! peptide hormone processing GO:0016486 23 15 0,000 0,03719949 0,06356674 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,03963032 0,06767249 ! G1 phase of mitotic cell cycle GO:0000080 35 16 0,000 0,03963032 0,0676245 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,03963032 0,06757657 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,03963032 0,06752871 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,03963032 0,06748092 ! bone remodeling GO:0046849 27 16 0,000 0,03963032 0,0674332 ! filopodium assembly GO:0046847 32 16 0,000 0,03963032 0,06738554 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 0,000 0,03963032 0,06733795 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,03963032 0,06729043 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,03963032 0,06724298 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,03963032 0,06719559 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,03963032 0,06714827 ! startle response GO:0001964 28 16 0,000 0,03963032 0,06710101 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,03963032 0,06705383 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,03963032 0,0670067 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,03963032 0,06695965 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,03963032 0,06691266 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,03963032 0,06686574 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,03963032 0,06681888 ! protein polyubiquitination GO:0000209 34 16 0,000 0,03963032 0,06677209 ! glutamate metabolic process GO:0006536 22 16 0,000 0,03963032 0,06672536 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,03963032 0,0666787 ! response to osmotic stress GO:0006970 25 16 0,000 0,03963032 0,0666321 ! lysosomal transport GO:0007041 26 16 0,000 0,03963032 0,06658557 ! fructose metabolic process GO:0006000 25 16 0,000 0,03963032 0,06653911 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,03963032 0,06649271 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,03963032 0,06644637 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,03963032 0,0664001 ! negative regulation of immune response GO:0050777 35 16 0,000 0,03963032 0,06635389 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,03963032 0,06630775 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,03963032 0,06626167 ! DNA replication initiation GO:0006270 27 16 0,000 0,03963032 0,06621565 ! neuron recognition GO:0008038 35 16 0,000 0,03963032 0,0661697 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,03963032 0,06612381 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,03963032 0,06607799 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,03963032 0,06603223 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,03963032 0,06598653 ! negative regulation of tissue remodeling GO:0034104 36 16 0,000 0,03963032 0,0659409 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,03963032 0,06589533 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,03963032 0,06584982 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,03963032 0,06580438 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,03963032 0,06575899 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,03963032 0,06571367 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,03963032 0,06566842 ! negative regulation of leukocyte proliferation GO:0070664 31 16 0,000 0,03963032 0,06562322 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,03963032 0,06557809 ! defense response to virus GO:0051607 37 16 0,000 0,03963032 0,06553302 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,04205509 0,06949488 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,04205509 0,06944718 ! metencephalon development GO:0022037 30 17 0,000 0,04205509 0,06939955 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,04205509 0,06935198 ! negative regulation of cell cycle process GO:0010948 32 17 0,000 0,04205509 0,06930448 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,04205509 0,06925705 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,04205509 0,06920967 ! endothelial cell migration GO:0043542 28 17 0,000 0,04205509 0,06916237 ! gene silencing by RNA GO:0031047 36 17 0,000 0,04205509 0,06911513 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,04205509 0,06906795 ! glial cell development GO:0021782 27 17 0,000 0,04205509 0,06902084 ! limbic system development GO:0021761 36 17 0,000 0,04205509 0,06897379 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,04205509 0,0689268 ! adult walking behavior GO:0007628 33 17 0,000 0,04205509 0,06887988 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,04205509 0,06883302 ! heart looping GO:0001947 30 17 0,000 0,04205509 0,06878623 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,04205509 0,0687395 ! regulation of viral genome replication GO:0045069 28 17 0,000 0,04205509 0,06869283 ! myoblast differentiation GO:0045445 45 17 0,000 0,04205509 0,06864623 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,04205509 0,06859969 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 0,000 0,04205509 0,06855321 ! regulation of survival gene product expression GO:0045884 33 17 0,000 0,04205509 0,0685068 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,04205509 0,06846045 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,04205509 0,06841416 ! glycine metabolic process GO:0006544 28 17 0,000 0,04205509 0,06836794 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,04205509 0,06832177 ! NAD metabolic process GO:0019674 29 17 0,000 0,04205509 0,06827567 ! membrane budding GO:0006900 37 17 0,000 0,04205509 0,06822963 ! DNA integration GO:0015074 29 17 0,000 0,04205509 0,06818366 ! regulation of protein binding GO:0043393 33 17 0,000 0,04205509 0,06813774 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,04205509 0,06809189 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,04205509 0,0680461 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,04205509 0,06800037 ! genitalia development GO:0048806 30 17 0,000 0,04205509 0,0679547 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 0,000 0,04205509 0,06790909 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,04205509 0,06786354 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,04205509 0,06781806 ! neutrophil chemotaxis GO:0030593 27 17 0,000 0,04205509 0,06777264 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,04205509 0,06772727 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,04205509 0,06768197 ! steroid catabolic process GO:0006706 31 17 0,000 0,04205509 0,06763673 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,04205509 0,06759155 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,04205509 0,06754642 ! gas transport GO:0015669 25 17 0,000 0,04205509 0,06750136 ! organic cation transport GO:0015695 31 17 0,000 0,04205509 0,06745636 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,04205509 0,06741142 ! negative regulation of homeostatic process GO:0032845 33 17 0,000 0,04205509 0,06736654 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,04205509 0,06732172 ! microspike assembly GO:0030035 36 17 0,000 0,04205509 0,06727696 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,04205509 0,06723226 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,04447382 0,0710518 ! neuron maturation GO:0042551 42 18 0,000 0,04447382 0,07100465 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,04447382 0,07095757 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,04447382 0,07091054 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,04447382 0,07086358 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,04447382 0,07081669 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,04447382 0,07076985 ! memory GO:0007613 31 18 0,000 0,04447382 0,07072307 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,04447382 0,07067636 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,04447382 0,07062971 ! patterning of blood vessels GO:0001569 39 18 0,000 0,04447382 0,07058312 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,04447382 0,07053659 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,04447382 0,07049013 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,04447382 0,07044372 ! epidermis morphogenesis GO:0048730 40 18 0,000 0,04447382 0,07039738 ! glutamine metabolic process GO:0006541 29 18 0,000 0,04447382 0,07035109 ! response to retinoic acid GO:0032526 26 18 0,000 0,04447382 0,07030487 ! cell-substrate junction assembly GO:0007044 54 18 0,000 0,04447382 0,07025871 ! response to fungus GO:0009620 21 18 0,000 0,04447382 0,07021261 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,04447382 0,07016657 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,04447382 0,07012058 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,04447382 0,07007466 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,04447382 0,0700288 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,04447382 0,069983 ! vitamin transport GO:0051180 27 18 0,000 0,04447382 0,06993726 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,04447382 0,06989158 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,04447382 0,06984596 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,04447382 0,0698004 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,04447382 0,0697549 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,04447382 0,06970945 ! nerve development GO:0021675 28 18 0,000 0,04447382 0,06966407 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,04447382 0,06961875 ! protein secretion GO:0009306 39 19 0,000 0,04688652 0,07334784 ! positive regulation of translation GO:0045727 30 19 0,000 0,04688652 0,07330018 ! negative regulation of defense response GO:0031348 25 19 0,000 0,04688652 0,07325258 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,04688652 0,07320505 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,04688652 0,07315757 ! skin development GO:0043588 36 19 0,000 0,04688652 0,07311016 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,04688652 0,07306281 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,04688652 0,07301552 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,04688652 0,07296829 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,04688652 0,07292112 ! bile acid metabolic process GO:0008206 29 19 0,000 0,04688652 0,07287402 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,04688652 0,07282697 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,04688652 0,07277999 ! cerebral cortex development GO:0021987 36 19 0,000 0,04688652 0,07273306 ! pigmentation during development GO:0048066 41 19 0,000 0,04688652 0,0726862 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,04688652 0,07263939 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 0,000 0,04688652 0,07259265 ! heme metabolic process GO:0042168 36 19 0,000 0,04688652 0,07254597 ! actin filament bundle formation GO:0051017 42 19 0,000 0,04688652 0,07249934 ! neuromuscular junction development GO:0007528 34 19 0,000 0,04688652 0,07245278 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,04688652 0,07240628 ! plasma membrane fusion GO:0045026 28 19 0,000 0,04688652 0,07235983 ! regulation of endothelial cell migration GO:0010594 44 19 0,000 0,04688652 0,07231345 ! peptide cross-linking GO:0018149 37 19 0,000 0,04688652 0,07226712 ! protein export from nucleus GO:0006611 36 19 0,000 0,04688652 0,07222086 ! heart process GO:0003015 30 19 0,000 0,04688652 0,07217465 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,04688652 0,0721285 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,04688652 0,07208241 ! visual learning GO:0008542 36 19 0,000 0,04688652 0,07203638 ! cellular pigmentation GO:0033059 36 19 0,000 0,04688652 0,07199041 ! G1 phase GO:0051318 40 19 0,000 0,04688652 0,0719445 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,04688652 0,07189865 ! cell-cell junction organization GO:0045216 35 19 0,000 0,04688652 0,07185285 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,04688652 0,07180712 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,04688652 0,07176144 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,04688652 0,07171582 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,04688652 0,07167025 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,04688652 0,07162475 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,04688652 0,0715793 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,04688652 0,07153391 ! cilium assembly GO:0042384 37 19 0,000 0,04688652 0,07148858 ! peptide hormone secretion GO:0030072 31 19 0,000 0,04688652 0,07144331 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,04929322 0,07506296 ! positive regulation of ossification GO:0045778 47 20 0,000 0,04929322 0,07501548 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,04929322 0,07496807 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,04929322 0,07492071 ! protein amino acid acetylation GO:0006473 39 20 0,000 0,04929322 0,07487341 ! cAMP metabolic process GO:0046058 36 20 0,000 0,04929322 0,07482617 ! response to vitamin GO:0033273 31 20 0,000 0,04929322 0,07477899 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,04929322 0,07473187 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,04929322 0,07468481 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,04929322 0,07463781 ! response to alkaloid GO:0043279 38 20 0,000 0,04929322 0,07459087 ! retinoid metabolic process GO:0001523 32 20 0,000 0,04929322 0,07454399 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,04929322 0,07449716 ! apoptotic mitochondrial changes GO:0008637 41 20 0,000 0,04929322 0,0744504 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,04929322 0,07440369 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,04929322 0,07435704 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,04929322 0,07431045 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 0,000 0,04929322 0,07426392 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,04929322 0,07421745 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,04929322 0,07417103 ! body fluid secretion GO:0007589 31 20 0,000 0,04929322 0,07412468 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,04929322 0,07407838 ! peptide secretion GO:0002790 35 20 0,000 0,04929322 0,07403213 ! stem cell differentiation GO:0048863 53 20 0,000 0,04929322 0,07398595 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,04929322 0,07393983 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,04929322 0,07389376 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,04929322 0,07384775 ! sensory perception of pain GO:0019233 30 20 0,000 0,04929322 0,07380179 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,04929322 0,0737559 ! diencephalon development GO:0021536 34 20 0,000 0,04929322 0,07371006 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,04929322 0,07366427 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,04929322 0,07361855 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,04929322 0,07357288 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,04929322 0,07352727 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,04929322 0,07348171 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,04929322 0,07343621 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,04929322 0,07339077 ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,04929322 0,07334538 ! regulation of glucose import GO:0046324 29 20 0,000 0,04929322 0,07330005 GO:0010827|regulation of glucose transport, ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,04929322 0,07325477 ! actin filament-based movement GO:0030048 43 20 0,000 0,04929322 0,07320956 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,04929322 0,07316439 ! negative regulation of T cell activation GO:0050868 40 20 0,000 0,04929322 0,07311928 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,04929322 0,07307423 ! negative regulation of translation GO:0017148 29 20 0,000 0,04929322 0,07302924 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,04929322 0,0729843 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,04929322 0,07293941 ! regulation of cell killing GO:0031341 42 21 0,000 0,05169391 0,07644472 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,05169391 0,07639776 ! hormone secretion GO:0046879 38 21 0,000 0,05169391 0,07635086 ! glycerol metabolic process GO:0006071 34 21 0,000 0,05169391 0,07630402 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,05169391 0,07625724 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,05169391 0,07621051 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,05169391 0,07616384 ! axis specification GO:0009798 38 21 0,000 0,05169391 0,07611723 ! ovarian follicle development GO:0001541 35 21 0,000 0,05169391 0,07607067 ! inactivation of MAPK activity GO:0000188 39 21 0,000 0,05169391 0,07602418 ! smooth muscle contraction GO:0006939 46 21 0,000 0,05169391 0,07597774 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,05169391 0,07593135 ! cell structure disassembly during apoptosis GO:0006921 30 21 0,000 0,05169391 0,07588502 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,05169391 0,07583875 ! cell aging GO:0007569 44 21 0,000 0,05169391 0,07579254 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,05169391 0,07574638 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,05169391 0,07570028 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,05169391 0,07565423 ! cytolysis GO:0019835 24 21 0,000 0,05169391 0,07560824 ! vasodilation GO:0042311 39 21 0,000 0,05169391 0,0755623 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,05169391 0,07551643 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,05169391 0,0754706 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,05169391 0,07542483 ! oogenesis GO:0048477 36 21 0,000 0,05169391 0,07537912 ! DNA modification GO:0006304 34 21 0,000 0,05169391 0,07533347 ! positive regulation of locomotion GO:0040017 39 21 0,000 0,05169391 0,07528786 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 59 21 0,000 0,05169391 0,07524232 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,05169391 0,07519683 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,05169391 0,07515139 ! negative regulation of intracellular transport GO:0032387 41 21 0,000 0,05169391 0,07510601 ! positive regulation of inflammatory response GO:0050729 35 21 0,000 0,05169391 0,07506068 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,05169391 0,07501541 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,05169391 0,07497019 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,05169391 0,07492503 ! response to cytokine stimulus GO:0034097 63 21 0,000 0,05169391 0,07487992 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,05169391 0,07483487 ! collagen catabolic process GO:0030574 28 21 0,000 0,05169391 0,07478987 ! sperm-egg recognition GO:0035036 21 21 0,000 0,05169391 0,07474492 ! gut development GO:0048565 39 21 0,000 0,05169391 0,07470003 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,05408862 0,07811358 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,05408862 0,07806672 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,05408862 0,07801992 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,05408862 0,07797318 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,05408862 0,07792649 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 40 22 0,000 0,05408862 0,07787985 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,05408862 0,07783327 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,05408862 0,07778675 ! regeneration GO:0031099 41 22 0,000 0,05408862 0,07774028 ! keratinization GO:0031424 28 22 0,000 0,05408862 0,07769387 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,05408862 0,07764751 ! sensory perception of taste GO:0050909 28 22 0,000 0,05408862 0,07760121 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 0,000 0,05408862 0,07755496 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 0,000 0,05408862 0,07750877 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,05408862 0,07746264 ! vacuolar transport GO:0007034 36 22 0,000 0,05408862 0,07741656 ! lysosome organization GO:0007040 41 22 0,000 0,05408862 0,07737053 ! central nervous system neuron development GO:0021954 46 22 0,000 0,05408862 0,07732456 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,05408862 0,07727864 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,05408862 0,07723278 ! fucose metabolic process GO:0006004 39 22 0,000 0,05408862 0,07718697 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,05408862 0,07714122 ! apoptotic nuclear changes GO:0030262 32 22 0,000 0,05408862 0,07709552 ! ureteric bud development GO:0001657 43 22 0,000 0,05408862 0,07704987 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,05408862 0,07700428 GO:0060415|muscle tissue morphogenesis, ! renal system process GO:0003014 41 22 0,000 0,05408862 0,07695874 ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,05408862 0,07691326 ! response to glucocorticoid stimulus GO:0051384 38 22 0,000 0,05408862 0,07686783 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,05408862 0,07682245 ! sarcomere organization GO:0045214 30 22 0,000 0,05408862 0,07677713 ! positive regulation of B cell activation GO:0050871 38 22 0,000 0,05408862 0,07673186 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,05408862 0,07668664 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,05408862 0,07664148 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,05408862 0,07659637 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 0,000 0,05408862 0,07655131 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,05647737 0,0798851 ! positive regulation of cell adhesion GO:0045785 56 23 0,000 0,05647737 0,07983816 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,05647737 0,07979128 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,05647737 0,07974445 ! gluconeogenesis GO:0006094 33 23 0,000 0,05647737 0,07969768 ! viral genome replication GO:0019079 41 23 0,000 0,05647737 0,07965097 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,05647737 0,07960431 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,05647737 0,0795577 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,05647737 0,07951115 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,05647737 0,07946465 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,05647737 0,07941821 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,05647737 0,07937182 ! visual behavior GO:0007632 42 23 0,000 0,05647737 0,07932548 ! regulation of cell-matrix adhesion GO:0001952 78 23 0,000 0,05647737 0,0792792 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 48 23 0,000 0,05647737 0,07923297 ! response to ethanol GO:0045471 46 23 0,000 0,05647737 0,0791868 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,05647737 0,07914068 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! activation of pro-apoptotic gene products GO:0008633 47 23 0,000 0,05647737 0,07909462 ! peroxisome organization GO:0007031 37 23 0,000 0,05647737 0,0790486 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,05647737 0,07900264 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,05647737 0,07895674 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,05647737 0,07891089 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,05647737 0,07886509 GO:0051693|actin filament capping, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,05647737 0,07881934 ! regulation of viral reproduction GO:0050792 38 23 0,000 0,05647737 0,07877365 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,05647737 0,07872801 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,05647737 0,07868243 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,05647737 0,07863689 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,05647737 0,07859141 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,05647737 0,07854598 ! fatty acid transport GO:0015908 44 23 0,000 0,05647737 0,07850061 ! platelet activation GO:0030168 37 23 0,000 0,05647737 0,07845528 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,05647737 0,07841001 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,05647737 0,07836479 ! hormone transport GO:0009914 40 23 0,000 0,05647737 0,07831962 ! cell-cell recognition GO:0009988 25 23 0,000 0,05647737 0,07827451 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,05647737 0,07822945 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,05647737 0,07818444 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,05647737 0,07813948 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,05647737 0,07809457 ! protein import into nucleus, translocation GO:0000060 46 24 0,000 0,05886016 0,08134265 ! positive regulation of fibroblast proliferation GO:0048146 43 24 0,000 0,05886016 0,08129595 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,05886016 0,08124931 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 35 24 0,000 0,05886016 0,08120272 ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,05886016 0,08115619 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,05886016 0,08110971 ! vesicle docking GO:0048278 47 24 0,000 0,05886016 0,08106328 ! spinal cord development GO:0021510 47 24 0,000 0,05886016 0,0810169 ! vacuole organization GO:0007033 43 24 0,000 0,05886016 0,08097058 ! multicellular organismal response to stress GO:0033555 49 24 0,000 0,05886016 0,08092431 ! digestive system process GO:0022600 39 24 0,000 0,05886016 0,0808781 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,05886016 0,08083193 ! response to corticosteroid stimulus GO:0031960 41 24 0,000 0,05886016 0,08078582 ! regulation of behavior GO:0050795 43 24 0,000 0,05886016 0,08073976 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,05886016 0,08069376 ! lymphocyte proliferation GO:0046651 48 24 0,000 0,05886016 0,0806478 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,05886016 0,0806019 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 47 24 0,000 0,05886016 0,08055606 ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,05886016 0,08051026 ! membrane depolarization GO:0051899 39 24 0,000 0,05886016 0,08046451 ! pallium development GO:0021543 49 24 0,000 0,05886016 0,08041882 ! pentose metabolic process GO:0019321 35 24 0,000 0,05886016 0,08037318 ! regulation of oxidoreductase activity GO:0051341 46 24 0,000 0,05886016 0,08032759 ! leukocyte homeostasis GO:0001776 44 24 0,000 0,05886016 0,08028206 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,05886016 0,08023657 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,05886016 0,08019114 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,05886016 0,08014575 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,05886016 0,08010042 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,05886016 0,08005514 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,05886016 0,08000991 ! regulation of amine transport GO:0051952 40 24 0,000 0,05886016 0,07996473 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,06123701 0,08314687 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 0,000 0,06123701 0,08309997 ! myelination GO:0042552 45 25 0,000 0,06123701 0,08305313 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,06123701 0,08300634 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,06123701 0,0829596 ! phototransduction GO:0007602 33 25 0,000 0,06123701 0,08291292 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,06123701 0,08286628 GO:0006479|protein amino acid methylation, ! vasculogenesis GO:0001570 46 25 0,000 0,06123701 0,0828197 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 0,000 0,06123701 0,08277318 ! sperm motility GO:0030317 31 25 0,000 0,06123701 0,0827267 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,06123701 0,08268028 ! negative regulation of DNA replication GO:0008156 42 25 0,000 0,06123701 0,08263391 ! chromosome condensation GO:0030261 45 25 0,000 0,06123701 0,08258759 ! response to starvation GO:0042594 42 25 0,000 0,06123701 0,08254132 ! osteoblast differentiation GO:0001649 60 25 0,000 0,06123701 0,0824951 ! neural crest cell development GO:0014032 54 25 0,000 0,06123701 0,08244894 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,06123701 0,08240283 ! negative regulation of cell development GO:0010721 73 25 0,000 0,06123701 0,08235677 GO:0050768|negative regulation of neurogenesis, ! regulation of insulin secretion GO:0050796 37 25 0,000 0,06123701 0,08231076 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,06123701 0,0822648 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,06123701 0,08221889 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 0,000 0,06123701 0,08217304 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,06123701 0,08212723 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! somitogenesis GO:0001756 43 25 0,000 0,06123701 0,08208148 ! immunoglobulin production GO:0002377 55 25 0,000 0,06123701 0,08203578 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,06123701 0,08199012 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,06123701 0,08194452 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,06123701 0,08189897 ! cellular response to nutrient levels GO:0031669 41 25 0,000 0,06123701 0,08185347 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,06123701 0,08180802 ! telomere organization GO:0032200 43 25 0,000 0,06123701 0,08176263 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,06123701 0,08171728 GO:0060606|tube closure, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,06360794 0,08483409 ! embryonic pattern specification GO:0009880 44 26 0,000 0,06360794 0,0847871 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,06360794 0,08474015 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,06360794 0,08469325 ! initiation of viral infection GO:0019059 57 26 0,000 0,06360794 0,08464641 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,06360794 0,08459962 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,06360794 0,08455288 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,06360794 0,08450619 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,06360794 0,08445955 ! molting cycle process GO:0022404 50 26 0,000 0,06360794 0,08441297 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! tube lumen formation GO:0035148 50 26 0,000 0,06360794 0,08436643 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,06360794 0,08431995 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,06360794 0,08427352 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,06360794 0,08422714 GO:0051297|centrosome organization, ! regulation of endothelial cell proliferation GO:0001936 57 26 0,000 0,06360794 0,08418081 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 0,000 0,06360794 0,08413453 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,06360794 0,0840883 ! cellular response to oxidative stress GO:0034599 39 26 0,000 0,06360794 0,08404212 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,06360794 0,083996 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,06360794 0,08394992 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,06360794 0,0839039 ! positive regulation of nuclear division GO:0051785 40 26 0,000 0,06360794 0,08385792 GO:0045840|positive regulation of mitosis, ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,06360794 0,083812 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,06360794 0,08376612 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,06360794 0,0837203 ! blastocyst development GO:0001824 49 26 0,000 0,06360794 0,08367453 ! leukocyte proliferation GO:0070661 52 26 0,000 0,06360794 0,0836288 GO:0032943|mononuclear cell proliferation, ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,06360794 0,08358313 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,06360794 0,0835375 ! regulation of fibroblast proliferation GO:0048145 52 27 0,000 0,06597296 0,08659626 ! neuron fate commitment GO:0048663 48 27 0,000 0,06597296 0,08654904 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 0,000 0,06597296 0,08650188 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,06597296 0,08645476 ! iron ion transport GO:0006826 59 27 0,000 0,06597296 0,0864077 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 0,000 0,06597296 0,08636069 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,06597296 0,08631373 ! protein amino acid acylation GO:0043543 55 27 0,000 0,06597296 0,08626682 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,06597296 0,08621996 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,06597296 0,08617315 ! fat cell differentiation GO:0045444 50 27 0,000 0,06597296 0,08612639 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,06597296 0,08607969 ! mitochondrial membrane organization GO:0007006 57 27 0,000 0,06597296 0,08603303 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,06597296 0,08598643 ! autophagy GO:0006914 41 27 0,000 0,06597296 0,08593987 ! male gonad development GO:0008584 44 27 0,000 0,06597296 0,08589337 ! response to toxin GO:0009636 47 27 0,000 0,06597296 0,08584691 ! primary neural tube formation GO:0014020 51 27 0,000 0,06597296 0,08580051 ! base-excision repair GO:0006284 41 27 0,000 0,06597296 0,08575416 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,06597296 0,08570785 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,06597296 0,0856616 ! regulation of chromosome organization GO:0033044 42 27 0,000 0,06597296 0,0856154 ! glutathione metabolic process GO:0006749 39 27 0,000 0,06597296 0,08556924 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,06597296 0,08552314 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,06597296 0,08547708 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,06597296 0,08543108 ! negative regulation of lymphocyte activation GO:0051250 53 27 0,000 0,06597296 0,08538512 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,06833209 0,08839086 ! circadian rhythm GO:0007623 50 28 0,000 0,06833209 0,08834336 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,06833209 0,08829592 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! negative regulation of protein modification process GO:0031400 60 28 0,000 0,06833209 0,08824852 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,06833209 0,08820118 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,06833209 0,08815389 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,06833209 0,08810664 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,06833209 0,08805945 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,06833209 0,08801231 ! synaptogenesis GO:0007416 42 28 0,000 0,06833209 0,08796522 ! lipid oxidation GO:0034440 43 28 0,000 0,06833209 0,08791818 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,06833209 0,08787119 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,06833209 0,08782425 ! translational initiation GO:0006413 65 29 0,000 0,07068533 0,09080027 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,07068533 0,09075182 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,07068533 0,09070341 ! regulation of pH GO:0006885 43 29 0,000 0,07068533 0,09065507 ! cellular iron ion homeostasis GO:0006879 51 29 0,000 0,07068533 0,09060677 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,07068533 0,09055852 ! catechol metabolic process GO:0009712 54 29 0,000 0,07068533 0,09051033 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,07068533 0,09046218 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,07068533 0,09041409 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,07068533 0,09036605 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,07068533 0,09031806 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,07068533 0,09027012 ! response to organic cyclic substance GO:0014070 55 29 0,000 0,07068533 0,09022223 ! cell fate determination GO:0001709 60 29 0,000 0,07068533 0,09017439 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,07068533 0,0901266 ! detection of light stimulus GO:0009583 38 29 0,000 0,07068533 0,09007887 ! cellular response to extracellular stimulus GO:0031668 48 29 0,000 0,07068533 0,09003118 ! negative regulation of neuron apoptosis GO:0043524 56 29 0,000 0,07068533 0,08998355 ! tissue homeostasis GO:0001894 48 29 0,000 0,07068533 0,08993596 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 46 29 0,000 0,07068533 0,08988843 ! phenol metabolic process GO:0018958 55 30 0,000 0,07303271 0,09282446 ! zinc ion transport GO:0006829 45 30 0,000 0,07303271 0,09277545 ! membrane docking GO:0022406 61 30 0,000 0,07303271 0,09272649 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,07303271 0,09267758 ! cell junction assembly GO:0034329 78 30 0,000 0,07303271 0,09262873 ! regulation of innate immune response GO:0045088 51 30 0,000 0,07303271 0,09257992 ! acute-phase response GO:0006953 49 30 0,000 0,07303271 0,09253117 ! myofibril assembly GO:0030239 47 30 0,000 0,07303271 0,09248247 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,07303271 0,09243382 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,07303271 0,09238522 ! positive regulation of multicellular organism growth GO:0040018 51 30 0,000 0,07303271 0,09233668 ! phospholipid transport GO:0015914 51 30 0,000 0,07303271 0,09228818 ! ensheathment of neurons GO:0007272 57 30 0,000 0,07303271 0,09223973 GO:0008366|axon ensheathment, ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,07303271 0,09219134 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,07303271 0,092143 ! negative regulation of leukocyte activation GO:0002695 56 30 0,000 0,07303271 0,0920947 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,07303271 0,09204646 ! eye morphogenesis GO:0048592 60 30 0,000 0,07303271 0,09199827 ! regulation of B cell activation GO:0050864 50 30 0,000 0,07303271 0,09195013 ! response to heat GO:0009408 50 30 0,000 0,07303271 0,09190204 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,07537423 0,09479896 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,07537423 0,09474943 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,07537423 0,09469995 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,07537423 0,09465053 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,07537423 0,09460115 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,07537423 0,09455183 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,07537423 0,09450256 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,07537423 0,09445334 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,07537423 0,09440417 ! ovulation cycle process GO:0022602 49 31 0,000 0,07537423 0,09435505 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,07537423 0,09430598 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,07537423 0,09425697 ! peptide transport GO:0015833 55 31 0,000 0,07537423 0,094208 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,07537423 0,09415909 ! iron ion homeostasis GO:0055072 54 31 0,000 0,07537423 0,09411023 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,07537423 0,09406141 ! mesoderm formation GO:0001707 69 31 0,000 0,07537423 0,09401265 ! natural killer cell activation GO:0030101 45 31 0,000 0,07537423 0,09396394 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,07537423 0,09391528 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,07537423 0,09386667 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,07537423 0,09381811 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,07537423 0,0937696 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,07770992 0,09662536 ! response to hydrogen peroxide GO:0042542 50 32 0,000 0,07770992 0,09657545 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,07770992 0,09652559 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,07770992 0,09647579 ! cholesterol transport GO:0030301 56 32 0,000 0,07770992 0,09642603 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,07770992 0,09637633 ! spliceosome assembly GO:0000245 67 32 0,000 0,07770992 0,09632668 ! spindle organization GO:0007051 46 32 0,000 0,07770992 0,09627707 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,07770992 0,09622752 ! metanephros development GO:0001656 74 32 0,000 0,07770992 0,09617802 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,07770992 0,09612857 ! response to ionizing radiation GO:0010212 65 32 0,000 0,07770992 0,09607918 ! response to mechanical stimulus GO:0009612 57 32 0,000 0,07770992 0,09602983 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,07770992 0,09598053 ! muscle cell development GO:0055001 49 32 0,000 0,07770992 0,09593129 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,07770992 0,09588209 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,07770992 0,09583295 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,07770992 0,09578385 ! negative regulation of MAP kinase activity GO:0043407 69 32 0,000 0,07770992 0,09573481 ! ovulation cycle GO:0042698 51 32 0,000 0,07770992 0,09568581 ! peripheral nervous system development GO:0007422 64 32 0,000 0,07770992 0,09563687 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,07770992 0,09558797 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,07770992 0,09553913 ! gene silencing GO:0016458 65 32 0,000 0,07770992 0,09549034 ! DNA damage checkpoint GO:0000077 71 33 0,000 0,08003979 0,09830308 ! post-embryonic development GO:0009791 69 33 0,000 0,08003979 0,09825293 ! positive regulation of gene-specific transcription GO:0043193 65 33 0,000 0,08003979 0,09820282 ! protein targeting to membrane GO:0006612 68 33 0,000 0,08003979 0,09815277 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,08003979 0,09810277 ! ceramide metabolic process GO:0006672 64 33 0,000 0,08003979 0,09805282 ! formation of primary germ layer GO:0001704 72 33 0,000 0,08003979 0,09800292 ! cell fate specification GO:0001708 52 33 0,000 0,08003979 0,09795307 ! sterol transport GO:0015918 57 33 0,000 0,08003979 0,09790327 ! leukocyte chemotaxis GO:0030595 50 33 0,000 0,08003979 0,09785352 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,08003979 0,09780383 ! adult locomotory behavior GO:0008344 59 33 0,000 0,08003979 0,09775418 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,08003979 0,09770458 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,08236385 0,10049058 ! glial cell differentiation GO:0010001 63 34 0,000 0,08236385 0,10043965 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,08236385 0,10038876 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,08236385 0,10033793 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,08236385 0,10028716 ! regulation of striated muscle tissue development GO:0016202 69 34 0,000 0,08236385 0,10023643 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,08236385 0,10018575 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,08236385 0,10013513 ! mismatch repair GO:0006298 46 34 0,000 0,08236385 0,10008456 ! spermatid development GO:0007286 63 34 0,000 0,08236385 0,10003403 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,08236385 0,09998356 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,08236385 0,09993314 ! placenta development GO:0001890 53 34 0,000 0,08236385 0,09988277 ! regulation of muscle development GO:0048634 70 35 0,000 0,08468211 0,1026424 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 0,000 0,08468211 0,10259072 ! negative regulation of secretion GO:0051048 63 35 0,000 0,08468211 0,10253909 ! negative regulation of DNA metabolic process GO:0051053 61 35 0,000 0,08468211 0,10248751 ! negative regulation of cell adhesion GO:0007162 81 35 0,000 0,08468211 0,10243598 ! odontogenesis GO:0042476 66 35 0,000 0,08468211 0,10238451 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,08468211 0,10233308 ! female gonad development GO:0008585 58 35 0,000 0,08468211 0,10228171 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,08468211 0,10223039 GO:0006639|acylglycerol metabolic process, ! telencephalon development GO:0021537 68 35 0,000 0,08468211 0,10217912 ! negative regulation of hydrolase activity GO:0051346 62 35 0,000 0,08468211 0,1021279 ! calcium-mediated signaling GO:0019722 62 35 0,000 0,08468211 0,10207674 ! cytokine production GO:0001816 59 35 0,000 0,08468211 0,10202562 ! vesicle localization GO:0051648 64 35 0,000 0,08468211 0,10197456 ! mitotic sister chromatid segregation GO:0000070 57 36 0,000 0,0869946 0,10470686 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,0869946 0,1046545 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,0869946 0,1046022 ! cell junction organization GO:0034330 86 36 0,000 0,0869946 0,10454995 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,0869946 0,10449775 ! positive regulation of cell development GO:0010720 80 36 0,000 0,0869946 0,10444561 ! DNA integrity checkpoint GO:0031570 75 36 0,000 0,0869946 0,10439352 ! regulation of proteolysis GO:0030162 72 36 0,000 0,0869946 0,10434148 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,0869946 0,10428949 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,0869946 0,10423755 ! aerobic respiration GO:0009060 55 36 0,000 0,0869946 0,10418567 ! androgen receptor signaling pathway GO:0030521 74 36 0,000 0,0869946 0,10413383 ! embryonic organ development GO:0048568 57 36 0,000 0,0869946 0,10408205 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,0869946 0,10403032 ! negative regulation of cell activation GO:0050866 65 36 0,000 0,0869946 0,10397864 ! RNA export from nucleus GO:0006405 56 37 0,000 0,08930132 0,10668271 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,08930132 0,10662976 ! meiosis I GO:0007127 65 37 0,000 0,08930132 0,10657687 ! sister chromatid segregation GO:0000819 58 37 0,000 0,08930132 0,10652403 ! actomyosin structure organization GO:0031032 62 37 0,000 0,08930132 0,10647124 ! organic anion transport GO:0015711 68 37 0,000 0,08930132 0,10641851 ! tissue remodeling GO:0048771 76 37 0,000 0,08930132 0,10636583 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,08930132 0,1063132 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,08930132 0,10626062 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,08930132 0,10620809 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,08930132 0,10615562 GO:0015986|ATP synthesis coupled proton transport, ! pigment metabolic process GO:0042440 80 37 0,000 0,08930132 0,10610319 ! spermatid differentiation GO:0048515 66 37 0,000 0,08930132 0,10605082 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,09160228 0,1087297 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,09160228 0,10867608 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,09160228 0,10862252 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,09160228 0,10856901 ! development of primary female sexual characteristics GO:0046545 67 38 0,000 0,09160228 0,10851556 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 67 38 0,000 0,09160228 0,10846215 ! lipid homeostasis GO:0055088 67 38 0,000 0,09160228 0,1084088 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,09160228 0,1083555 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,09160228 0,10830226 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,09160228 0,10824907 ! positive regulation of leukocyte proliferation GO:0070665 62 38 0,000 0,09160228 0,10819592 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,09160228 0,10814283 ! mRNA catabolic process GO:0006402 71 39 0,000 0,09389751 0,11079815 ! mammary gland development GO:0030879 86 39 0,000 0,09389751 0,11074383 ! learning GO:0007612 77 39 0,000 0,09389751 0,11068957 ! ear morphogenesis GO:0042471 60 39 0,000 0,09389751 0,11063537 ! organic ether metabolic process GO:0018904 55 39 0,000 0,09389751 0,11058121 ! development of primary male sexual characteristics GO:0046546 66 39 0,000 0,09389751 0,11052711 ! segmentation GO:0035282 67 39 0,000 0,09389751 0,11047307 ! ion transmembrane transport GO:0034220 66 39 0,000 0,09389751 0,11041907 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,09389751 0,11036513 ! regulation of action potential in neuron GO:0019228 73 39 0,000 0,09389751 0,11031124 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,09389751 0,1102574 ! RNA modification GO:0009451 57 39 0,000 0,09389751 0,11020362 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,09389751 0,11014989 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,09618702 0,11278069 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,09618702 0,11272575 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,09618702 0,11267087 ! feeding behavior GO:0007631 59 40 0,000 0,09618702 0,11261605 ! multicellular organismal metabolic process GO:0044236 57 40 0,000 0,09618702 0,11256127 ! mesenchymal cell development GO:0014031 87 40 0,000 0,09618702 0,11250655 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,09618702 0,11245188 ! cytokinesis GO:0000910 72 40 0,000 0,09618702 0,11239727 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,09847082 0,11501009 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,09847082 0,11495429 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,09847082 0,11489854 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,09847082 0,11484285 ! gliogenesis GO:0042063 88 41 0,000 0,09847082 0,11478721 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,09847082 0,11473162 ! regulation of T cell proliferation GO:0042129 71 41 0,000 0,09847082 0,11467608 ! T cell differentiation GO:0030217 81 41 0,000 0,09847082 0,11462061 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,09847082 0,11456518 ! regulation of T cell differentiation GO:0045580 70 41 0,000 0,09847082 0,11450981 ! female gamete generation GO:0007292 61 41 0,000 0,09847082 0,11445449 ! dorsal/ventral pattern formation GO:0009953 68 41 0,000 0,09847082 0,11439922 ! positive regulation of transcription factor activity GO:0051091 62 42 0,000 0,10074892 0,11698934 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 67 42 0,000 0,10074892 0,1169329 ! regulation of tube size GO:0035150 71 42 0,000 0,10074892 0,11687652 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,10074892 0,1168202 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,10074892 0,11676392 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,10074892 0,11670771 ! neuron migration GO:0001764 79 42 0,000 0,10074892 0,11665154 ! regulation of protein secretion GO:0050708 71 42 0,000 0,10074892 0,11659543 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,10074892 0,11653938 ! epithelial cell differentiation GO:0030855 79 43 0,000 0,10302134 0,11911069 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,10302134 0,11905348 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,10302134 0,11899633 ! glucose transport GO:0015758 65 43 0,000 0,10302134 0,11893923 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,10302134 0,11888218 ! positive regulation of response to external stimulus GO:0032103 77 43 0,000 0,10302134 0,11882519 ! regulation of epithelial cell proliferation GO:0050678 111 43 0,000 0,10302134 0,11876826 ! striated muscle contraction GO:0006941 77 43 0,000 0,10302134 0,11871138 ! phagocytosis GO:0006909 90 43 0,000 0,10302134 0,11865455 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,10302134 0,11859778 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,1052881 0,12114929 ! hexose transport GO:0008645 67 44 0,000 0,1052881 0,12109138 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,1052881 0,12103352 ! male sex differentiation GO:0046661 76 44 0,000 0,1052881 0,12097572 ! double-strand break repair GO:0006302 81 44 0,000 0,1052881 0,12091798 ! biopolymer methylation GO:0043414 84 44 0,000 0,1052881 0,12086029 ! B cell differentiation GO:0030183 107 44 0,000 0,1052881 0,12080265 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,1052881 0,12074507 ! JAK-STAT cascade GO:0007259 71 44 0,000 0,1052881 0,12068755 ! developmental growth GO:0048589 82 44 0,000 0,1052881 0,12063008 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,1075492 0,12316201 ! glycolysis GO:0006096 65 45 0,000 0,1075492 0,12310341 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,1075492 0,12304488 ! leukocyte migration GO:0050900 68 45 0,000 0,1075492 0,12298639 ! detection of stimulus involved in sensory perception GO:0050906 66 45 0,000 0,1075492 0,12292797 ! branching morphogenesis of a tube GO:0048754 97 45 0,000 0,1075492 0,1228696 ! induction of apoptosis by intracellular signals GO:0008629 93 45 0,000 0,1075492 0,12281128 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,1075492 0,12275302 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,1075492 0,12269482 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,1075492 0,12263667 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,1075492 0,12257858 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,1075492 0,12252054 ! cell growth GO:0016049 84 45 0,000 0,1075492 0,12246255 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 0,000 0,10980466 0,12497163 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,10980466 0,12491254 ! negative regulation of cell migration GO:0030336 115 46 0,000 0,10980466 0,12485351 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,10980466 0,12479453 ! pigmentation GO:0043473 100 46 0,000 0,10980466 0,12473561 ! positive regulation of defense response GO:0031349 76 47 0,000 0,1120545 0,1272313 ! response to calcium ion GO:0051592 81 47 0,000 0,1120545 0,12717129 ! positive regulation of DNA binding GO:0043388 73 47 0,000 0,1120545 0,12711133 ! vascular process in circulatory system GO:0003018 80 47 0,000 0,1120545 0,12705143 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,1120545 0,12699158 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,1120545 0,12693179 ! JNK cascade GO:0007254 91 47 0,000 0,1120545 0,12687206 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,1120545 0,12681238 ! methylation GO:0032259 90 47 0,000 0,1120545 0,12675276 ! positive regulation of cell cycle GO:0045787 89 48 0,000 0,11429872 0,12923061 ! mitochondrial transport GO:0006839 82 48 0,000 0,11429872 0,12916991 ! Notch signaling pathway GO:0007219 96 48 0,000 0,11429872 0,12910926 ! cellular component disassembly GO:0022411 86 48 0,000 0,11429872 0,12904868 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,11429872 0,12898815 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,11429872 0,12892767 ! activation of caspase activity GO:0006919 84 48 0,000 0,11429872 0,12886726 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,11429872 0,1288069 ! regulation of inflammatory response GO:0050727 75 48 0,000 0,11429872 0,1287466 ! regulation of lymphocyte differentiation GO:0045619 81 48 0,000 0,11429872 0,12868635 ! regulation of mast cell proliferation GO:0070666 81 48 0,000 0,11429872 0,12862616 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,11653735 0,13108409 ! regulation of action potential GO:0001508 95 49 0,000 0,11653735 0,13102284 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,11653735 0,13096164 ! regulation of ion transport GO:0043269 77 49 0,000 0,11653735 0,1309005 ! induction of apoptosis by extracellular signals GO:0008624 89 49 0,000 0,11653735 0,13083942 ! peptide metabolic process GO:0006518 76 49 0,000 0,11653735 0,13077839 ! response to temperature stimulus GO:0009266 76 49 0,000 0,11653735 0,13071742 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,11653735 0,13065651 ! endocrine system development GO:0035270 104 49 0,000 0,11653735 0,13059565 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,11653735 0,13053486 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,11653735 0,13047411 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,11653735 0,13041343 ! detection of abiotic stimulus GO:0009582 74 49 0,000 0,11653735 0,1303528 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,1187704 0,13278883 ! neuromuscular process GO:0050905 99 50 0,000 0,1187704 0,13272716 ! regulation of ossification GO:0030278 117 50 0,000 0,1187704 0,13266554 ! inner ear development GO:0048839 79 50 0,000 0,1187704 0,13260398 ! histone modification GO:0016570 91 50 0,000 0,1187704 0,13254247 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,1187704 0,13248103 ! negative regulation of immune system process GO:0002683 95 50 0,000 0,1187704 0,13241964 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,1187704 0,1323583 ! positive regulation of binding GO:0051099 78 51 0,000 0,12099787 0,13477818 ! viral infectious cycle GO:0019058 99 51 0,000 0,12099787 0,13471581 ! response to estrogen stimulus GO:0043627 93 51 0,000 0,12099787 0,1346535 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,12099787 0,13459125 ! embryonic skeletal system development GO:0048706 85 51 0,000 0,12099787 0,13452905 ! excretion GO:0007588 83 51 0,000 0,12099787 0,13446692 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,12099787 0,13440484 ! chromatin remodeling GO:0006338 109 51 0,000 0,12099787 0,13434281 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,12099787 0,13428085 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,12099787 0,13421894 ! vesicle organization GO:0016050 107 51 0,000 0,12099787 0,13415708 ! regulation of leukocyte proliferation GO:0070663 88 51 0,000 0,12099787 0,13409529 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of cell shape GO:0008360 125 51 0,000 0,12099787 0,13403355 ! regulation of angiogenesis GO:0045765 114 52 0,000 0,12321979 0,13643203 ! regulation of muscle contraction GO:0006937 81 52 0,000 0,12321979 0,13636928 ! membrane fusion GO:0006944 110 52 0,000 0,12321979 0,13630658 ! covalent chromatin modification GO:0016569 101 52 0,000 0,12321979 0,13624394 ! morphogenesis of a branching structure GO:0001763 111 52 0,000 0,12321979 0,13618135 ! amino acid activation GO:0043038 92 52 0,000 0,12321979 0,13611883 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! cartilage development GO:0051216 90 52 0,000 0,12321979 0,13605636 ! synapse organization GO:0050808 85 52 0,000 0,12321979 0,13599395 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,12543616 0,13837662 ! RNA catabolic process GO:0006401 93 53 0,000 0,12543616 0,1383132 ! regulation of translational initiation GO:0006446 82 53 0,000 0,12543616 0,13824984 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,12543616 0,13818654 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,12543616 0,1381233 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,12543616 0,13806011 ! cell maturation GO:0048469 100 53 0,000 0,12543616 0,13799698 ! regulation of neuron apoptosis GO:0043523 100 53 0,000 0,12543616 0,13793391 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,12543616 0,1378709 ! activation of phospholipase C activity GO:0007202 103 54 0,000 0,12764701 0,14023685 GO:0010863|positive regulation of phospholipase C activity, ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,12764701 0,14017284 ! cell recognition GO:0008037 85 54 0,000 0,12764701 0,14010889 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,12764701 0,14004501 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,12764701 0,13998117 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,12764701 0,1399174 ! chloride transport GO:0006821 90 55 0,000 0,12985234 0,14226991 ! positive regulation of caspase activity GO:0043280 95 55 0,000 0,12985234 0,14220515 GO:0010952|positive regulation of peptidase activity, ! glucose catabolic process GO:0006007 82 55 0,000 0,12985234 0,14214046 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,12985234 0,14207582 ! positive regulation of phospholipase activity GO:0010518 104 55 0,000 0,12985234 0,14201124 ! aging GO:0007568 103 55 0,000 0,12985234 0,14194672 ! gastrulation GO:0007369 112 55 0,000 0,12985234 0,14188225 ! regulation of multicellular organism growth GO:0040014 85 55 0,000 0,12985234 0,14181785 ! RNA elongation GO:0006354 79 55 0,000 0,12985234 0,1417535 ! nuclear export GO:0051168 97 55 0,000 0,12985234 0,14168922 ! negative regulation of cell motion GO:0051271 134 55 0,000 0,12985234 0,14162499 ! regulation of actin filament length GO:0030832 105 56 0,000 0,13205216 0,143959 ! sensory perception of smell GO:0007608 80 56 0,000 0,13205216 0,1438938 ! skeletal muscle fiber development GO:0048741 111 56 0,000 0,13205216 0,14382866 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,13205216 0,14376358 ! nucleotide-excision repair GO:0006289 83 56 0,000 0,13205216 0,14369856 ! proton transport GO:0015992 94 56 0,000 0,13205216 0,14363359 ! positive regulation of organelle organization GO:0010638 100 56 0,000 0,13205216 0,14356869 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 0,000 0,1342465 0,14588848 ! regulation of bone remodeling GO:0046850 137 57 0,000 0,1342465 0,14582261 ! muscle fiber development GO:0048747 112 57 0,000 0,1342465 0,14575681 ! regulation of phospholipase activity GO:0010517 106 57 0,000 0,1342465 0,14569106 ! hydrogen transport GO:0006818 97 58 0,000 0,13643537 0,14799977 ! regulation of tissue remodeling GO:0034103 140 58 0,000 0,13643537 0,14793308 ! regulation of endocytosis GO:0030100 91 58 0,000 0,13643537 0,14786644 ! adult behavior GO:0030534 99 58 0,000 0,13643537 0,14779986 ! positive regulation of lipase activity GO:0060193 108 58 0,000 0,13643537 0,14773335 ! positive regulation of secretion GO:0051047 95 59 0,000 0,13861877 0,15003003 ! regulation of cellular component size GO:0032535 109 59 0,000 0,13861877 0,14996257 ! skeletal system morphogenesis GO:0048705 105 59 0,000 0,13861877 0,14989517 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,13861877 0,14982784 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,13861877 0,14976056 ! DNA catabolic process GO:0006308 86 59 0,000 0,13861877 0,14969334 ! establishment of organelle localization GO:0051656 109 59 0,000 0,13861877 0,14962618 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,14079673 0,15190893 ! DNA damage response, signal transduction GO:0042770 128 60 0,000 0,14079673 0,15184084 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,14079673 0,15177281 ! regulation of heart contraction GO:0008016 110 60 0,000 0,14079673 0,15170485 ! camera-type eye development GO:0043010 116 60 0,000 0,14079673 0,15163694 ! negative regulation of response to stimulus GO:0048585 100 60 0,000 0,14079673 0,15156909 ! kidney development GO:0001822 122 60 0,000 0,14079673 0,15150131 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,14296925 0,15377023 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,14296925 0,15370152 ! mesoderm development GO:0007498 119 61 0,000 0,14296925 0,15363287 ! tRNA processing GO:0008033 89 61 0,000 0,14296925 0,15356429 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,14296925 0,15349576 ! ear development GO:0043583 103 62 0,000 0,14513635 0,15575292 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,14513635 0,15568348 ! gonad development GO:0008406 98 62 0,000 0,14513635 0,1556141 ! regulation of homeostatic process GO:0032844 134 62 0,000 0,14513635 0,15554479 ! regulation of mitosis GO:0007088 105 63 0,000 0,14729804 0,15779122 GO:0051783|regulation of nuclear division, ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,14729804 0,157721 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,14729804 0,15765084 ! detection of external stimulus GO:0009581 91 63 0,000 0,14729804 0,15758074 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,14729804 0,1575107 ! steroid hormone receptor signaling pathway GO:0030518 129 63 0,000 0,14729804 0,15744073 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 0,000 0,14945433 0,15967457 ! cell redox homeostasis GO:0045454 102 64 0,000 0,14945433 0,1596037 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,14945433 0,15953289 ! multicellular organism reproduction GO:0032504 111 64 0,000 0,14945433 0,15946214 GO:0048609|reproductive process in a multicellular organism, ! single fertilization GO:0007338 75 64 0,000 0,14945433 0,15939146 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,15160525 0,16161375 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,15160525 0,16154217 ! embryonic limb morphogenesis GO:0030326 125 65 0,000 0,15160525 0,16147066 GO:0035113|embryonic appendage morphogenesis, ! germ cell development GO:0007281 118 65 0,000 0,15160525 0,16139922 ! myeloid cell differentiation GO:0030099 111 65 0,000 0,15160525 0,16132783 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,1537508 0,16353865 ! extracellular matrix organization GO:0030198 133 66 0,000 0,1537508 0,16346638 ! secondary metabolic process GO:0019748 116 66 0,000 0,1537508 0,16339418 ! developmental maturation GO:0021700 116 66 0,000 0,1537508 0,16332204 ! cell projection assembly GO:0030031 120 66 0,000 0,1537508 0,16324996 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,15589099 0,16544937 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,15589099 0,16537642 ! negative regulation of cell growth GO:0030308 132 67 0,000 0,15589099 0,16530354 ! lung development GO:0030324 144 67 0,000 0,15589099 0,16523072 ! chromosome segregation GO:0007059 113 67 0,000 0,15589099 0,16515796 ! homeostasis of number of cells GO:0048872 114 67 0,000 0,15589099 0,16508527 ! hexose catabolic process GO:0019320 104 67 0,000 0,15589099 0,16501264 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 0,000 0,15589099 0,16494007 ! positive regulation of T cell activation GO:0050870 109 67 0,000 0,15589099 0,16486757 ! adaptive immune response GO:0002250 119 67 0,000 0,15589099 0,16479513 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 0,000 0,15589099 0,16472276 ! amino acid transport GO:0006865 125 68 0,000 0,15802584 0,16690526 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,15802584 0,16683202 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 0,000 0,15802584 0,16675885 ! regulation of lipase activity GO:0060191 130 68 0,000 0,15802584 0,16668574 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,15802584 0,1666127 ! negative regulation of cell size GO:0045792 134 69 0,000 0,16015536 0,16878397 ! urogenital system development GO:0001655 137 69 0,000 0,16015536 0,16871007 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,16015536 0,16863624 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,16015536 0,16856247 ! antigen processing and presentation GO:0019882 104 69 0,000 0,16015536 0,16848877 ! appendage morphogenesis GO:0035107 135 70 0,000 0,16227957 0,17064889 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 150 70 0,000 0,16227957 0,17057433 ! amine catabolic process GO:0009310 117 71 0,000 0,16439848 0,17272609 ! reproductive structure development GO:0048608 113 71 0,000 0,16439848 0,17265069 ! appendage development GO:0048736 136 71 0,000 0,16439848 0,17257537 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 0,000 0,16439848 0,1725001 ! B cell activation GO:0042113 160 71 0,000 0,16439848 0,17242491 ! regulation of MAPKKK cascade GO:0043408 142 71 0,000 0,16439848 0,17234978 ! regulation of immune effector process GO:0002697 137 71 0,000 0,16439848 0,17227471 ! acute inflammatory response GO:0002526 113 72 0,000 0,16651209 0,17441363 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 0,000 0,16651209 0,17433773 ! carbohydrate transport GO:0008643 110 72 0,000 0,16651209 0,1742619 ! respiratory system development GO:0060541 153 72 0,000 0,16651209 0,17418613 ! learning or memory GO:0007611 147 73 0,000 0,16862043 0,17631498 ! regulation of blood pressure GO:0008217 125 73 0,000 0,16862043 0,17623839 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,16862043 0,17616186 ! axon guidance GO:0007411 139 73 0,000 0,16862043 0,1760854 ! fertilization GO:0009566 90 73 0,000 0,16862043 0,17600901 ! transition metal ion transport GO:0000041 126 74 0,000 0,17072351 0,17812696 ! neurotransmitter transport GO:0006836 123 74 0,000 0,17072351 0,17804975 ! meiosis GO:0007126 121 74 0,000 0,17072351 0,1779726 GO:0051327|M phase of meiotic cell cycle, ! exocytosis GO:0006887 133 74 0,000 0,17072351 0,17789553 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,17072351 0,17781851 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,17072351 0,17774157 ! eye development GO:0001654 143 74 0,000 0,17072351 0,17766469 ! organelle localization GO:0051640 136 74 0,000 0,17072351 0,17758788 ! cell-matrix adhesion GO:0007160 163 75 0,000 0,17282134 0,17969237 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,17282134 0,17961475 ! phosphoinositide-mediated signaling GO:0048015 131 75 0,000 0,17282134 0,17953719 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,17282134 0,17945971 ! meiotic cell cycle GO:0051321 122 75 0,000 0,17282134 0,17938229 ! rhythmic process GO:0048511 128 75 0,000 0,17282134 0,17930493 ! lymphocyte differentiation GO:0030098 167 75 0,000 0,17282134 0,17922765 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,17491393 0,18131965 ! development of primary sexual characteristics GO:0045137 124 76 0,000 0,17491393 0,18124156 ! defense response to bacterium GO:0042742 89 76 0,000 0,17491393 0,18116354 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,17491393 0,18108559 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,17491393 0,1810077 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,17700129 0,18308904 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,17700129 0,18301036 ! positive regulation of lymphocyte activation GO:0051251 127 77 0,000 0,17700129 0,18293175 ! blood coagulation GO:0007596 146 78 0,000 0,17908345 0,1850042 GO:0050817|coagulation, ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,17908345 0,1849248 ! response to steroid hormone stimulus GO:0048545 137 78 0,000 0,17908345 0,18484546 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,1811604 0,18690906 ! activation of protein kinase activity GO:0032147 147 79 0,000 0,1811604 0,18682894 ! positive regulation of phosphorylation GO:0042327 129 79 0,000 0,1811604 0,1867489 ! response to metal ion GO:0010038 140 80 0,000 0,18323217 0,18880369 ! muscle cell differentiation GO:0042692 159 80 0,000 0,18323217 0,18872286 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,18323217 0,18864211 ! protein import into nucleus GO:0006606 158 80 0,000 0,18323217 0,18856142 ! inorganic anion transport GO:0015698 138 80 0,000 0,18323217 0,18848081 ! T cell activation GO:0042110 168 81 0,000 0,18529877 0,19052514 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 0,000 0,18529877 0,19044376 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 171 81 0,000 0,18529877 0,19036244 ! digestion GO:0007586 112 81 0,000 0,18529877 0,19028119 ! cell-substrate adhesion GO:0031589 171 81 0,000 0,18529877 0,19020002 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,18529877 0,19011891 ! nuclear import GO:0051170 161 81 0,000 0,18529877 0,19003787 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,1873602 0,19207015 ! response to drug GO:0042493 143 82 0,000 0,1873602 0,19198835 ! response to nutrient GO:0007584 125 82 0,000 0,1873602 0,19190662 ! response to oxygen levels GO:0070482 176 83 0,000 0,18941649 0,19393025 ! hemostasis GO:0007599 158 84 0,000 0,19146765 0,1959469 ! negative regulation of growth GO:0045926 155 84 0,000 0,19146765 0,19586359 ! response to unfolded protein GO:0006986 131 85 0,000 0,19351368 0,19787246 ! nucleosome assembly GO:0006334 122 85 0,000 0,19351368 0,19778841 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,19351368 0,19770442 ! positive regulation of cell activation GO:0050867 145 85 0,000 0,19351368 0,1976205 GO:0002696|positive regulation of leukocyte activation, ! amine biosynthetic process GO:0009309 138 86 0,000 0,1955546 0,19962001 ! response to inorganic substance GO:0010035 153 86 0,000 0,1955546 0,19953535 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,1955546 0,19945077 ! chromatin assembly GO:0031497 124 86 0,000 0,1955546 0,19936626 ! mitochondrion organization GO:0007005 148 86 0,000 0,1955546 0,19928182 ! alcohol catabolic process GO:0046164 130 86 0,000 0,1955546 0,19919745 ! amine transport GO:0015837 155 86 0,000 0,1955546 0,19911315 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,19759042 0,20110091 ! protein localization in nucleus GO:0034504 176 87 0,000 0,19759042 0,20101588 ! cellular respiration GO:0045333 135 88 0,000 0,19962116 0,20299599 ! positive regulation of protein modification process GO:0031401 136 88 0,000 0,19962116 0,20291023 ! gland development GO:0048732 206 88 0,000 0,19962116 0,20282454 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,19962116 0,20273893 ! cellular defense response GO:0006968 114 89 0,000 0,20164683 0,20470982 ! regulation of cell morphogenesis GO:0022604 215 89 0,000 0,20164683 0,20462348 ! regulation of cell adhesion GO:0030155 212 89 0,000 0,20164683 0,20453722 ! ossification GO:0001503 188 90 0,000 0,20366744 0,20649973 ! regulation of cell cycle process GO:0010564 149 90 0,000 0,20366744 0,20641275 ! sex differentiation GO:0007548 145 90 0,000 0,20366744 0,20632584 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,20366744 0,206239 ! bone development GO:0060348 189 91 0,000 0,205683 0,20819239 ! sterol metabolic process GO:0016125 152 91 0,000 0,205683 0,20810484 ! response to protein stimulus GO:0051789 149 91 0,000 0,205683 0,20801736 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,205683 0,20792996 ! regulation of defense response GO:0031347 149 92 0,000 0,20769353 0,20987427 ! nucleosome organization GO:0034728 138 92 0,000 0,20769353 0,20978616 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,20769353 0,20969813 ! vitamin metabolic process GO:0006766 139 92 0,000 0,20769353 0,20961017 ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,20969904 0,21154544 ! regulation of membrane potential GO:0042391 164 93 0,000 0,20969904 0,21145678 ! negative regulation of multicellular organismal process GO:0051241 166 93 0,000 0,20969904 0,21136819 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,21169953 0,21329526 ! transcription initiation GO:0006352 153 94 0,000 0,21169953 0,21320597 ! regulation of T cell activation GO:0050863 158 94 0,000 0,21169953 0,21311677 ! interphase of mitotic cell cycle GO:0051329 209 95 0,000 0,21369503 0,21503565 ! forebrain development GO:0030900 188 95 0,000 0,21369503 0,21494575 ! leukocyte differentiation GO:0002521 202 96 0,000 0,21568554 0,21685726 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,21568554 0,21676667 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,21568554 0,21667616 ! positive regulation of immune response GO:0050778 156 96 0,000 0,21568554 0,21658573 ! detection of stimulus GO:0051606 151 96 0,000 0,21568554 0,21649537 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,21767108 0,21839726 ! protein ubiquitination GO:0016567 217 97 0,000 0,21767108 0,21830622 ! hormone metabolic process GO:0042445 157 97 0,000 0,21767108 0,21821526 ! response to virus GO:0009615 160 98 0,000 0,21965166 0,22010908 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,21965166 0,22001744 ! interphase GO:0051325 213 98 0,000 0,21965166 0,21992588 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,21965166 0,2198344 GO:0016054|organic acid catabolic process, ! Golgi vesicle transport GO:0048193 207 99 0,000 0,22162729 0,22171945 ! skeletal muscle tissue development GO:0007519 186 99 0,000 0,22162729 0,22162729 GO:0060538|skeletal muscle organ development,