pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6619-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 7,357E-09 1,692E-05 ! cellular response to insulin stimulus GO:0032869 52 34 6,000 3,133E-08 3,603E-05 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 3,000 4,284E-08 3,284E-05 ! response to peptide hormone stimulus GO:0043434 84 57 7,000 7,468E-08 4,294E-05 ! insulin receptor signaling pathway GO:0008286 40 24 5,000 9,01E-08 4,145E-05 ! cell-matrix adhesion GO:0007160 114 61 7,000 1,288E-07 4,936E-05 ! response to insulin stimulus GO:0032868 63 43 6,000 1,743E-07 5,729E-05 ! cell-substrate adhesion GO:0031589 121 66 7,000 2,41E-07 6,929E-05 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 3,000 2,953E-07 7,547E-05 ! integrin-mediated signaling pathway GO:0007229 81 49 6,000 4,425E-07 1,018E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 6,000 5,868E-07 1,227E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 3,000 1,047E-06 2,007E-04 ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 1,888E-06 3,34E-04 ! interphase GO:0051325 159 88 7,000 2,25E-06 3,696E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 2,259E-06 3,464E-04 ! peptidyl-amino acid modification GO:0018193 147 93 7,000 3,421E-06 4,918E-04 ! response to UV GO:0009411 75 46 5,000 5,253E-06 7,107E-04 ! cellular response to hormone stimulus GO:0032870 109 74 6,000 7,561E-06 9,661E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 8,007E-06 9,693E-04 ! cell adhesion mediated by integrin GO:0033627 8 5 2,000 8,906E-06 1,024E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 2,000 8,906E-06 9,755E-04 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 8,906E-06 9,311E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 1,769E-05 1,769E-03 ! ER overload response GO:0006983 7 6 2,000 1,769E-05 1,695E-03 ! purine salvage GO:0043101 8 6 2,000 1,769E-05 1,627E-03 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 1,769E-05 1,564E-03 ! nucleoside catabolic process GO:0009164 6 6 2,000 1,769E-05 1,507E-03 ! inactivation of MAPK activity GO:0000188 27 17 3,000 1,861E-05 1,529E-03 ! cell-substrate junction assembly GO:0007044 39 17 3,000 1,861E-05 1,476E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 2,375E-05 1,82E-03 ! gut development GO:0048565 26 18 3,000 2,375E-05 1,762E-03 ! apoptotic nuclear changes GO:0030262 24 19 3,000 2,985E-05 2,145E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 3,073E-05 2,142E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 3,073E-05 2,079E-03 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 2,000 3,073E-05 2,019E-03 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! B cell lineage commitment GO:0002326 17 7 2,000 3,073E-05 1,963E-03 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 3,073E-05 1,91E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 3,073E-05 1,86E-03 ! positive regulation of inflammatory response GO:0050729 30 20 3,000 3,703E-05 2,184E-03 ! purine ribonucleoside metabolic process GO:0046128 28 21 3,000 4,54E-05 2,61E-03 GO:0042278|purine nucleoside metabolic process, ! response to endoplasmic reticulum stress GO:0034976 25 21 3,000 4,54E-05 2,547E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 3,000 4,54E-05 2,486E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 4,881E-05 2,611E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 4,881E-05 2,552E-03 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 4,881E-05 2,495E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 5,507E-05 2,753E-03 GO:0010810|regulation of cell-substrate adhesion, ! negative regulation of cell migration GO:0030336 92 44 4,000 6,551E-05 3,206E-03 ! regulation of inflammatory response GO:0050727 60 44 4,000 6,551E-05 3,139E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 3,000 6,615E-05 3,105E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 6,615E-05 3,043E-03 ! negative regulation of striated muscle development GO:0045843 11 9 2,000 7,27E-05 3,278E-03 ! DNA ligation GO:0006266 14 9 2,000 7,27E-05 3,215E-03 ! cellular metabolic compound salvage GO:0043094 11 9 2,000 7,27E-05 3,155E-03 ! mitochondrial membrane organization GO:0007006 39 24 3,000 7,878E-05 3,356E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 9,308E-05 3,893E-03 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of muscle development GO:0048635 12 10 2,000 1,031E-04 4,235E-03 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 2,000 1,031E-04 4,161E-03 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 2,000 1,031E-04 4,089E-03 ! negative regulation of ossification GO:0030279 19 10 2,000 1,031E-04 4,019E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 3,000 1,092E-04 4,185E-03 ! lipid modification GO:0030258 73 50 4,000 1,219E-04 4,597E-03 ! negative regulation of cell motion GO:0051271 104 51 4,000 1,341E-04 4,976E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 1,408E-04 5,139E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 24 11 2,000 1,408E-04 5,059E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 1,408E-04 4,981E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 1,408E-04 4,905E-03 GO:0010829|negative regulation of glucose transport, ! cell junction assembly GO:0034329 56 28 3,000 1,473E-04 5,056E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 3,000 1,473E-04 4,981E-03 ! regulation of cell adhesion GO:0030155 159 83 5,000 1,573E-04 5,245E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,863E-04 6,123E-03 ! regulation of striated muscle tissue development GO:0016202 47 31 3,000 2,212E-04 7,167E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 2,281E-04 7,287E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 2,405E-04 7,578E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 2,477E-04 7,698E-03 ! regulation of muscle development GO:0048634 48 32 3,000 2,509E-04 7,695E-03 ! regulation of protein stability GO:0031647 48 32 3,000 2,509E-04 7,594E-03 ! glycerophospholipid metabolic process GO:0006650 130 92 5,000 2,766E-04 8,263E-03 ! cell junction organization GO:0034330 63 33 3,000 2,834E-04 8,357E-03 ! nucleus organization GO:0006997 49 33 3,000 2,834E-04 8,251E-03 ! phosphoinositide metabolic process GO:0030384 87 60 4,000 2,906E-04 8,356E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 3,039E-04 8,63E-03 ! inositol metabolic process GO:0006020 20 14 2,000 3,039E-04 8,525E-03 ! cellular response to starvation GO:0009267 21 14 2,000 3,039E-04 8,422E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 3,141E-04 8,601E-03 ! response to light stimulus GO:0009416 153 96 5,000 3,483E-04 9,426E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 3,772E-04 0,01008785 ! cardiac muscle tissue development GO:0048738 23 15 2,000 3,772E-04 9,972E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 3,772E-04 9,859E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 3,772E-04 9,748E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 3,772E-04 9,64E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 3,772E-04 9,534E-03 ! defense response to virus GO:0051607 27 15 2,000 3,772E-04 9,43E-03 ! ribonucleoside metabolic process GO:0009119 48 37 3,000 4,438E-04 0,01097509 ! endothelial cell migration GO:0043542 22 16 2,000 4,609E-04 0,01127818 ! neutrophil chemotaxis GO:0030593 21 16 2,000 4,609E-04 0,01115947 ! negative regulation of translation GO:0017148 22 16 2,000 4,609E-04 0,01104322 ! pigmentation GO:0043473 74 38 3,000 4,923E-04 0,01167193 ! regulation of viral genome replication GO:0045069 24 17 2,000 5,557E-04 0,01304237 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 5,557E-04 0,01291063 ! neuromuscular junction development GO:0007528 23 17 2,000 5,557E-04 0,01278152 ! peptidyl-serine modification GO:0018209 27 17 2,000 5,557E-04 0,01265497 ! proximal/distal pattern formation GO:0009954 25 17 2,000 5,557E-04 0,01253091 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 5,957E-04 0,01330184 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 6,003E-04 0,01327623 ! B cell differentiation GO:0030183 62 40 3,000 6,003E-04 0,01314979 ! phosphoinositide-mediated signaling GO:0048015 109 71 4,000 6,358E-04 0,01379653 ! regulation of T cell differentiation GO:0045580 59 41 3,000 6,602E-04 0,01419148 ! cellular response to nutrient levels GO:0031669 27 18 2,000 6,621E-04 0,01410056 ! regulation of glucose import GO:0046324 21 18 2,000 6,621E-04 0,01397119 GO:0010827|regulation of glucose transport, ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 6,78E-04 0,01417601 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 4,000 6,78E-04 0,0140483 ! mitochondrion organization GO:0007005 104 73 4,000 7,222E-04 0,01483052 ! mitochondrial transport GO:0006839 60 42 3,000 7,242E-04 0,0147408 ! response to oxygen levels GO:0070482 137 74 4,000 7,685E-04 0,01550483 ! response to alkaloid GO:0043279 32 19 2,000 7,807E-04 0,01561325 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 7,807E-04 0,01547865 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 7,807E-04 0,01534636 ! response to starvation GO:0042594 30 19 2,000 7,807E-04 0,0152163 ! epithelial tube morphogenesis GO:0060562 65 43 3,000 7,925E-04 0,01531721 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 8,652E-04 0,01658297 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 9,119E-04 0,01733348 ! positive regulation of locomotion GO:0040017 35 20 2,000 9,119E-04 0,0171914 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 1,000 9,222E-04 0,01724378 ! apoptotic cell clearance GO:0043277 13 5 1,000 9,222E-04 0,01710472 ! positive regulation of glycolysis GO:0045821 11 5 1,000 9,222E-04 0,01696788 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 9,222E-04 0,01683322 ! epithelial cell proliferation GO:0050673 6 5 1,000 9,222E-04 0,01670067 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 9,222E-04 0,0165702 ! microvillus organization GO:0032528 7 5 1,000 9,222E-04 0,01644175 GO:0030033|microvillus assembly, ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 9,222E-04 0,01631527 ! peptidyl-histidine phosphorylation GO:0018106 7 5 1,000 9,222E-04 0,01619073 ! nucleoside salvage GO:0043174 7 5 1,000 9,222E-04 0,01606807 GO:0006166|purine ribonucleoside salvage, ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 9,222E-04 0,01594726 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 9,222E-04 0,01582825 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 8 5 1,000 9,222E-04 0,015711 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 1,000 9,222E-04 0,01559548 ! enteric nervous system development GO:0048484 8 5 1,000 9,222E-04 0,01548164 ! regulation of respiratory burst GO:0060263 8 5 1,000 9,222E-04 0,01536946 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 9,222E-04 0,01525889 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 9,222E-04 0,01514989 ! receptor biosynthetic process GO:0032800 6 5 1,000 9,222E-04 0,01504245 ! positive regulation of defense response GO:0031349 59 45 3,000 9,425E-04 0,01526544 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 9,425E-04 0,01515868 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 1,056E-03 0,01687158 ! regulation of chemotaxis GO:0050920 36 21 2,000 1,056E-03 0,01675522 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 1,056E-03 0,01664046 ! cell aging GO:0007569 32 21 2,000 1,056E-03 0,01652726 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 1,111E-03 0,01727139 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA replication GO:0006275 75 48 3,000 1,203E-03 0,0185746 ! regulation of lymphocyte differentiation GO:0045619 69 48 3,000 1,203E-03 0,01845077 ! leukocyte adhesion GO:0007159 38 22 2,000 1,214E-03 0,01849746 ! ureteric bud development GO:0001657 32 22 2,000 1,214E-03 0,01837577 ! regulation of behavior GO:0050795 38 22 2,000 1,214E-03 0,01825566 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 1,214E-03 0,01813712 ! protein tetramerization GO:0051262 39 22 2,000 1,214E-03 0,01802011 ! regulation of defense response GO:0031347 117 84 4,000 1,362E-03 0,02008795 ! regulation of helicase activity GO:0051095 11 6 1,000 1,374E-03 0,02013465 ! male meiosis GO:0007140 7 6 1,000 1,374E-03 0,02000721 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,374E-03 0,01988138 ! pigment granule organization GO:0048753 11 6 1,000 1,374E-03 0,01975712 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,374E-03 0,01963441 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,374E-03 0,01951321 ! neuron apoptosis GO:0051402 8 6 1,000 1,374E-03 0,0193935 ! male sex determination GO:0030238 9 6 1,000 1,374E-03 0,01927524 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 1,374E-03 0,01915842 ! deoxyribonucleoside metabolic process GO:0009120 7 6 1,000 1,374E-03 0,01904301 ! interaction with symbiont GO:0051702 8 6 1,000 1,374E-03 0,01892898 ! DNA topological change GO:0006265 8 6 1,000 1,374E-03 0,01881631 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 1,000 1,374E-03 0,01870497 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,374E-03 0,01859494 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,374E-03 0,0184862 ! peptidyl-histidine modification GO:0018202 9 6 1,000 1,374E-03 0,01837872 ! myelination GO:0042552 35 23 2,000 1,387E-03 0,01843503 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 1,387E-03 0,01832909 ! regulation of viral reproduction GO:0050792 32 23 2,000 1,387E-03 0,01822435 ! interaction with host GO:0051701 37 23 2,000 1,387E-03 0,0181208 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 2,000 1,387E-03 0,01801842 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! regulation of DNA metabolic process GO:0051052 135 85 4,000 1,436E-03 0,01856059 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 1,436E-03 0,0184569 ! regulation of membrane potential GO:0042391 128 85 4,000 1,436E-03 0,01835436 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,511E-03 0,01919932 ! cell cycle arrest GO:0007050 150 86 4,000 1,513E-03 0,01912392 ! fat cell differentiation GO:0045444 37 24 2,000 1,573E-03 0,01977587 ! response to toxin GO:0009636 38 24 2,000 1,573E-03 0,01966839 ! negative regulation of cell development GO:0010721 56 24 2,000 1,573E-03 0,01956207 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 2,000 1,573E-03 0,0194569 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 1,775E-03 0,02183576 ! leukocyte differentiation GO:0002521 143 90 4,000 1,851E-03 0,02264828 ! cytokine-mediated signaling pathway GO:0019221 76 54 3,000 1,869E-03 0,02274928 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,912E-03 0,02314382 ! lipoprotein transport GO:0042953 9 7 1,000 1,912E-03 0,02302265 ! reflex GO:0060004 12 7 1,000 1,912E-03 0,02290274 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,912E-03 0,02278407 ! organ growth GO:0035265 11 7 1,000 1,912E-03 0,02266663 ! behavioral fear response GO:0001662 13 7 1,000 1,912E-03 0,02255039 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 1,912E-03 0,02243534 ! response to UV-B GO:0010224 11 7 1,000 1,912E-03 0,02232145 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,912E-03 0,02220872 ! regulation of fat cell differentiation GO:0045598 9 7 1,000 1,912E-03 0,02209712 ! response to tumor cell GO:0002347 12 7 1,000 1,912E-03 0,02198663 ! neuroblast proliferation GO:0007405 13 7 1,000 1,912E-03 0,02187725 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,912E-03 0,02176894 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,912E-03 0,02166171 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 1,912E-03 0,02155552 ! response to virus GO:0009615 122 91 4,000 1,944E-03 0,02180767 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,993E-03 0,02224824 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 1,993E-03 0,02214076 ! nucleoside metabolic process GO:0009116 69 55 3,000 2,001E-03 0,02212554 ! cell fate commitment GO:0045165 141 92 4,000 2,04E-03 0,02244466 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 2,139E-03 0,02342387 ! positive regulation of cell motion GO:0051272 99 56 3,000 2,139E-03 0,02331286 ! response to ionizing radiation GO:0010212 47 27 2,000 2,226E-03 0,0241484 ! viral reproductive process GO:0022415 87 58 3,000 2,434E-03 0,02627889 ! regulation of response to external stimulus GO:0032101 139 96 4,000 2,458E-03 0,0264127 ! positive regulation of T cell differentiation GO:0045582 39 28 2,000 2,475E-03 0,02647976 ! ensheathment of neurons GO:0007272 43 28 2,000 2,475E-03 0,02635717 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 2,000 2,475E-03 0,02623571 ! placenta development GO:0001890 37 28 2,000 2,475E-03 0,02611536 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 1,000 2,533E-03 0,02660127 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 2,533E-03 0,02648036 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 2,533E-03 0,02636054 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,533E-03 0,0262418 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,533E-03 0,02612412 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,533E-03 0,02600749 ! middle ear morphogenesis GO:0042474 9 8 1,000 2,533E-03 0,02589191 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,533E-03 0,02577734 ! melanin metabolic process GO:0006582 12 8 1,000 2,533E-03 0,02566378 ! regulation of gliogenesis GO:0014013 20 8 1,000 2,533E-03 0,02555122 GO:0045685|regulation of glial cell differentiation, ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 2,533E-03 0,02543965 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,533E-03 0,02532904 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,533E-03 0,02521939 ! regulation of embryonic development GO:0045995 16 8 1,000 2,533E-03 0,02511068 ! mitochondrion localization GO:0051646 12 8 1,000 2,533E-03 0,02500291 ! tissue homeostasis GO:0001894 42 29 2,000 2,741E-03 0,02694468 GO:0048871|multicellular organismal homeostasis, ! embryonic limb morphogenesis GO:0030326 86 60 3,000 2,755E-03 0,02696812 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 2,81E-03 0,02738076 ! embryonic epithelial tube formation GO:0001838 44 30 2,000 3,024E-03 0,02935021 ! negative regulation of cell growth GO:0030308 106 62 3,000 3,105E-03 0,03000847 ! regulation of developmental growth GO:0048638 13 9 1,000 3,236E-03 0,0311397 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,236E-03 0,03100995 ! regulation of glycolysis GO:0006110 15 9 1,000 3,236E-03 0,03088127 ! T cell selection GO:0045058 18 9 1,000 3,236E-03 0,03075367 ! L-serine metabolic process GO:0006563 13 9 1,000 3,236E-03 0,03062711 ! motor axon guidance GO:0008045 14 9 1,000 3,236E-03 0,03050159 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 3,236E-03 0,03037709 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 3,236E-03 0,03025361 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 1,000 3,236E-03 0,03013112 ! oocyte differentiation GO:0009994 12 9 1,000 3,236E-03 0,03000963 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 3,236E-03 0,0298891 ! spleen development GO:0048536 15 9 1,000 3,236E-03 0,02976955 ! regulation of RNA splicing GO:0043484 14 9 1,000 3,236E-03 0,02965094 ! blastocyst formation GO:0001825 12 9 1,000 3,236E-03 0,02953328 ! response to nicotine GO:0035094 16 9 1,000 3,236E-03 0,02941655 ! localization within membrane GO:0051668 15 9 1,000 3,236E-03 0,02930074 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 3,291E-03 0,02968331 ! viral reproduction GO:0016032 92 63 3,000 3,291E-03 0,02956736 ! DNA damage checkpoint GO:0000077 53 31 2,000 3,325E-03 0,02975395 ! metanephros development GO:0001656 58 31 2,000 3,325E-03 0,02963862 ! leukocyte chemotaxis GO:0030595 43 31 2,000 3,325E-03 0,02952419 GO:0060326|cell chemotaxis, ! cell cycle checkpoint GO:0000075 108 64 3,000 3,484E-03 0,03082139 ! negative regulation of cell size GO:0045792 108 64 3,000 3,484E-03 0,0307033 ! appendage morphogenesis GO:0035107 93 64 3,000 3,484E-03 0,03058611 GO:0035108|limb morphogenesis, ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 3,484E-03 0,03046982 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 2,000 3,643E-03 0,03173524 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 3,643E-03 0,03161549 ! regulation of caspase activity GO:0043281 97 65 3,000 3,685E-03 0,03186198 ! appendage development GO:0048736 94 65 3,000 3,685E-03 0,03174265 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 3,000 3,685E-03 0,0316242 ! negative regulation of cell adhesion GO:0007162 67 33 2,000 3,979E-03 0,03401759 ! carbohydrate homeostasis GO:0033500 39 33 2,000 3,979E-03 0,0338916 GO:0042593|glucose homeostasis, ! regulation of B cell proliferation GO:0030888 15 10 1,000 4,019E-03 0,03410958 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 4,019E-03 0,03398418 ! hair follicle morphogenesis GO:0031069 17 10 1,000 4,019E-03 0,03385969 ! hippocampus development GO:0021766 19 10 1,000 4,019E-03 0,03373612 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 4,019E-03 0,03361344 ! glucan biosynthetic process GO:0009250 13 10 1,000 4,019E-03 0,03349165 GO:0005978|glycogen biosynthetic process, ! response to X-ray GO:0010165 16 10 1,000 4,019E-03 0,03337075 ! B cell proliferation GO:0042100 14 10 1,000 4,019E-03 0,03325071 ! fear response GO:0042596 16 10 1,000 4,019E-03 0,03313153 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 4,019E-03 0,0330132 ! alpha-beta T cell activation GO:0046631 16 10 1,000 4,019E-03 0,03289572 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 4,019E-03 0,03277907 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 4,019E-03 0,03266324 GO:0043470|regulation of carbohydrate catabolic process, ! embryonic gut development GO:0048566 11 10 1,000 4,019E-03 0,03254823 ! cardiac cell differentiation GO:0035051 16 10 1,000 4,019E-03 0,03243402 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 4,11E-03 0,03304978 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 4,333E-03 0,03472243 ! DNA integrity checkpoint GO:0031570 57 34 2,000 4,333E-03 0,03460187 ! neuron migration GO:0001764 46 34 2,000 4,333E-03 0,03448214 ! polyol metabolic process GO:0019751 44 34 2,000 4,333E-03 0,03436323 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 4,705E-03 0,03719096 ! regulation of action potential in neuron GO:0019228 54 35 2,000 4,705E-03 0,0370636 ! glycogen metabolic process GO:0005977 48 35 2,000 4,705E-03 0,0369371 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 4,705E-03 0,03681146 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! virus-host interaction GO:0019048 17 11 1,000 4,881E-03 0,03805392 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,881E-03 0,03792536 ! filopodium assembly GO:0046847 19 11 1,000 4,881E-03 0,03779767 ! detection of mechanical stimulus GO:0050982 15 11 1,000 4,881E-03 0,03767083 ! regulation of mRNA processing GO:0050684 18 11 1,000 4,881E-03 0,03754484 ! plasma membrane organization GO:0007009 18 11 1,000 4,881E-03 0,03741969 ! regulation of intracellular pH GO:0051453 17 11 1,000 4,881E-03 0,03729537 ! regulation of phagocytosis GO:0050764 14 11 1,000 4,881E-03 0,03717188 ! nucleoside triphosphate catabolic process GO:0009143 15 11 1,000 4,881E-03 0,0370492 ! T cell homeostasis GO:0043029 20 11 1,000 4,881E-03 0,03692733 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 4,881E-03 0,03680625 ! digestive tract morphogenesis GO:0048546 15 11 1,000 4,881E-03 0,03668597 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! germ cell migration GO:0008354 18 11 1,000 4,881E-03 0,03656647 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 4,881E-03 0,03644775 GO:0042130|negative regulation of T cell proliferation, ! lymphocyte differentiation GO:0030098 113 71 3,000 5,056E-03 0,03763381 ! glucan metabolic process GO:0044042 49 36 2,000 5,097E-03 0,0378163 GO:0006073|cellular glucan metabolic process, ! regulation of peptidase activity GO:0052547 106 72 3,000 5,314E-03 0,03929637 ! negative regulation of transport GO:0051051 116 73 3,000 5,58E-03 0,04113254 ! tube morphogenesis GO:0035239 118 73 3,000 5,58E-03 0,04100113 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 5,82E-03 0,04262857 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 5,82E-03 0,04249324 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 5,82E-03 0,04235877 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 5,82E-03 0,04222515 ! autonomic nervous system development GO:0048483 23 12 1,000 5,82E-03 0,04209236 ! gland morphogenesis GO:0022612 23 12 1,000 5,82E-03 0,04196041 ! peptidyl-lysine modification GO:0018205 18 12 1,000 5,82E-03 0,04182929 ! microspike assembly GO:0030035 23 12 1,000 5,82E-03 0,04169898 ! positive regulation of lymphocyte activation GO:0051251 108 74 3,000 5,855E-03 0,0418189 ! regulation of T cell proliferation GO:0042129 58 38 2,000 5,937E-03 0,04227899 ! mesenchymal cell development GO:0014031 64 38 2,000 5,937E-03 0,0421485 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! negative regulation of growth GO:0045926 123 75 3,000 6,138E-03 0,04344139 ! response to nutrient GO:0007584 104 75 3,000 6,138E-03 0,04330813 ! morphogenesis of embryonic epithelium GO:0016331 60 39 2,000 6,387E-03 0,04492288 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 6,387E-03 0,04478592 ! synapse organization GO:0050808 55 39 2,000 6,387E-03 0,0446498 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 6,834E-03 0,04763181 ! regulation of cell-cell adhesion GO:0022407 27 13 1,000 6,834E-03 0,0474879 ! deoxyribonucleotide catabolic process GO:0009264 16 13 1,000 6,834E-03 0,04734487 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 1,000 6,834E-03 0,04720269 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 6,834E-03 0,04706137 ! regulation of cellular pH GO:0030641 20 13 1,000 6,834E-03 0,04692089 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 6,834E-03 0,04678124 ! cellular pigmentation GO:0033059 24 13 1,000 6,834E-03 0,04664242 ! lymphocyte homeostasis GO:0002260 24 13 1,000 6,834E-03 0,04650443 ! T cell differentiation GO:0030217 65 40 2,000 6,856E-03 0,04651592 ! positive regulation of protein modification process GO:0031401 107 78 3,000 7,044E-03 0,04765333 ! energy reserve metabolic process GO:0006112 59 41 2,000 7,345E-03 0,04954231 ! T cell activation GO:0042110 134 79 3,000 7,365E-03 0,04953039 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 7,854E-03 0,0526686 ! cellular component disassembly GO:0022411 64 42 2,000 7,854E-03 0,05251549 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 7,922E-03 0,05281664 ! neuron maturation GO:0042551 21 14 1,000 7,922E-03 0,05266399 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 7,922E-03 0,05251222 ! heterophilic cell adhesion GO:0007157 29 14 1,000 7,922E-03 0,05236132 ! limbic system development GO:0021761 25 14 1,000 7,922E-03 0,05221129 ! epidermis morphogenesis GO:0048730 29 14 1,000 7,922E-03 0,05206212 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 7,922E-03 0,05191379 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 7,922E-03 0,05176631 ! G1/S transition checkpoint GO:0031575 33 14 1,000 7,922E-03 0,05161966 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 1,000 7,922E-03 0,05147384 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 7,922E-03 0,05132885 ! cell killing GO:0001906 20 14 1,000 7,922E-03 0,05118467 ! positive regulation of cell activation GO:0050867 120 81 3,000 8,035E-03 0,05176345 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 3,000 8,384E-03 0,05386302 GO:0060348|bone development, ! regulation of gene-specific transcription GO:0032583 69 43 2,000 8,384E-03 0,05371455 ! leukocyte migration GO:0050900 60 43 2,000 8,384E-03 0,05356534 ! activation of caspase activity GO:0006919 65 43 2,000 8,384E-03 0,05341696 ! regulation of action potential GO:0001508 71 44 2,000 8,934E-03 0,05676493 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 8,934E-03 0,05660855 ! metencephalon development GO:0022037 19 15 1,000 9,083E-03 0,05739455 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 9,083E-03 0,0572373 ! lipid phosphorylation GO:0046834 23 15 1,000 9,083E-03 0,05708092 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 9,083E-03 0,05692538 ! bile acid metabolic process GO:0008206 22 15 1,000 9,083E-03 0,0567707 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 9,083E-03 0,05661685 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 9,083E-03 0,05646383 ! regulation of protein localization GO:0032880 132 85 3,000 9,491E-03 0,05883957 ! positive regulation of cell cycle GO:0045787 77 45 2,000 9,505E-03 0,05876841 ! cell maturation GO:0048469 60 45 2,000 9,505E-03 0,05861085 ! regulation of ossification GO:0030278 71 46 2,000 0,01009683 0,06209278 ! cellular defense response GO:0006968 102 87 3,000 0,01027962 0,06304833 ! skeletal muscle tissue development GO:0007519 123 87 3,000 0,01027962 0,06288064 GO:0060538|skeletal muscle organ development, ! regulation of glucose metabolic process GO:0010906 22 16 1,000 0,01031508 0,06293019 ! protein amino acid acetylation GO:0006473 28 16 1,000 0,01031508 0,06276371 ! cellular response to unfolded protein GO:0034620 19 16 1,000 0,01031508 0,06259811 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 1,000 0,01031508 0,06243338 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 0,01031508 0,06226951 ! DNA replication initiation GO:0006270 25 16 1,000 0,01031508 0,0621065 ! oogenesis GO:0048477 23 16 1,000 0,01031508 0,06194434 ! neural crest cell migration GO:0001755 24 16 1,000 0,01031508 0,06178303 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 0,01031508 0,06162255 ! nerve development GO:0021675 18 16 1,000 0,01031508 0,06146291 ! viral infectious cycle GO:0019058 71 47 2,000 0,01070947 0,06364802 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 0,01070947 0,06348397 ! regulation of neurogenesis GO:0050767 153 89 3,000 0,01110942 0,06568552 ! regulation of T cell activation GO:0050863 128 89 3,000 0,01110942 0,0655171 ! positive regulation of caspase activity GO:0043280 72 48 2,000 0,01134321 0,06672479 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 0,01134321 0,06655457 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 0,01134321 0,06638522 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 1,000 0,01161633 0,06781105 GO:0019692|deoxyribose phosphate metabolic process, ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 1,000 0,01161633 0,06763938 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 1,000 0,01161633 0,06746857 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 0,01161633 0,06729862 ! forelimb morphogenesis GO:0035136 19 17 1,000 0,01161633 0,06712953 ! memory GO:0007613 25 17 1,000 0,01161633 0,06696129 ! keratinization GO:0031424 17 17 1,000 0,01161633 0,06679388 ! actin filament bundle formation GO:0051017 26 17 1,000 0,01161633 0,06662731 ! long-chain fatty acid transport GO:0015909 24 17 1,000 0,01161633 0,06646158 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 0,01161633 0,06629666 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 0,01161633 0,06613256 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 2,000 0,01199818 0,0681378 ! regulation of intracellular transport GO:0032386 78 49 2,000 0,01199818 0,06796997 ! heterocycle catabolic process GO:0046700 72 49 2,000 0,01199818 0,06780297 ! cartilage development GO:0051216 70 49 2,000 0,01199818 0,06763679 ! ear development GO:0043583 72 50 2,000 0,01267447 0,07127453 ! positive regulation of growth GO:0045927 67 50 2,000 0,01267447 0,07110069 ! skeletal muscle fiber development GO:0048741 73 50 2,000 0,01267447 0,0709277 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 0,01267447 0,07075554 ! positive regulation of DNA replication GO:0045740 29 18 1,000 0,0129856 0,07231692 ! response to retinoic acid GO:0032526 25 18 1,000 0,0129856 0,07214225 ! pigmentation during development GO:0048066 31 18 1,000 0,0129856 0,07196841 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 0,0129856 0,07179541 ! prostaglandin metabolic process GO:0006693 31 18 1,000 0,0129856 0,07162324 GO:0006692|prostanoid metabolic process, ! somitogenesis GO:0001756 24 18 1,000 0,0129856 0,07145189 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 0,0129856 0,07128136 ! purine nucleotide catabolic process GO:0006195 26 18 1,000 0,0129856 0,07111164 ! negative regulation of T cell activation GO:0050868 25 18 1,000 0,0129856 0,07094273 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 0,0129856 0,07077462 ! activation of phospholipase C activity GO:0007202 87 51 2,000 0,01337219 0,07270933 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 2,000 0,01337219 0,07253785 ! angiogenesis GO:0001525 149 95 3,000 0,0138538 0,07497352 ! positive regulation of phospholipase activity GO:0010518 88 52 2,000 0,01409144 0,07608053 ! aging GO:0007568 79 52 2,000 0,01409144 0,07590236 ! nucleotide-excision repair GO:0006289 64 52 2,000 0,01409144 0,07572502 ! in utero embryonic development GO:0001701 147 96 3,000 0,01434929 0,07693094 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01442148 0,07713815 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,01442148 0,07695917 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 0,01442148 0,07678103 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 0,01442148 0,0766037 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,01442148 0,0764272 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 0,01442148 0,0762515 ! response to vitamin A GO:0033189 26 19 1,000 0,01442148 0,07607661 ! D-ribose metabolic process GO:0006014 25 19 1,000 0,01442148 0,07590253 ! sex determination GO:0007530 29 19 1,000 0,01442148 0,07572923 ! renal system process GO:0003014 35 19 1,000 0,01442148 0,07555673 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 0,01442148 0,07538501 ! sarcomere organization GO:0045214 23 19 1,000 0,01442148 0,07521407 ! glycerophospholipid biosynthetic process GO:0046474 75 53 2,000 0,01483229 0,07718157 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01483229 0,07700735 ! kidney development GO:0001822 90 53 2,000 0,01483229 0,07683391 ! cell projection assembly GO:0030031 76 53 2,000 0,01483229 0,07666125 ! regulation of phospholipase activity GO:0010517 90 54 2,000 0,01559481 0,08042165 ! DNA catabolic process GO:0006308 67 54 2,000 0,01559481 0,08024174 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01559481 0,08006263 ! positive regulation of lipase activity GO:0060193 90 54 2,000 0,01559481 0,07988432 ! extracellular structure organization GO:0043062 156 99 3,000 0,01590267 0,0812803 ! protein amino acid O-linked glycosylation GO:0006493 29 20 1,000 0,01592255 0,08120145 ! response to vitamin GO:0033273 29 20 1,000 0,01592255 0,0810218 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01592255 0,08084294 ! response to ethanol GO:0045471 37 20 1,000 0,01592255 0,08066488 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01592255 0,08048759 ! chromosome condensation GO:0030261 31 20 1,000 0,01592255 0,08031108 ! fatty acid beta-oxidation GO:0006635 31 20 1,000 0,01592255 0,08013535 ! pallium development GO:0021543 38 20 1,000 0,01592255 0,07996038 ! DNA modification GO:0006304 28 20 1,000 0,01592255 0,07978617 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01592255 0,07961273 ! collagen catabolic process GO:0030574 25 20 1,000 0,01592255 0,07944003 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 0,01718513 0,08555367 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 0,01748741 0,08687051 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01748741 0,08668329 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01748741 0,08649688 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01748741 0,08631126 ! ovarian follicle development GO:0001541 30 21 1,000 0,01748741 0,08612644 ! deoxyribonucleotide metabolic process GO:0009262 27 21 1,000 0,01748741 0,08594241 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01748741 0,08575916 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 0,01748741 0,0855767 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01748741 0,08539501 ! fatty acid transport GO:0015908 30 21 1,000 0,01748741 0,08521409 ! platelet activation GO:0030168 28 21 1,000 0,01748741 0,08503393 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01748741 0,08485453 ! regulation of bone mineralization GO:0030500 29 21 1,000 0,01748741 0,08467589 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01748741 0,084498 ! secondary metabolic process GO:0019748 84 57 2,000 0,01801303 0,08685529 ! developmental maturation GO:0021700 75 57 2,000 0,01801303 0,08667358 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01911471 0,09178255 ! viral genome replication GO:0019079 29 22 1,000 0,01911471 0,09159134 ! spliceosomal snRNP biogenesis GO:0000387 28 22 1,000 0,01911471 0,09140092 ! molting cycle process GO:0022404 40 22 1,000 0,01911471 0,09121129 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01911471 0,09102245 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01911471 0,09083438 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01911471 0,0906471 ! blastocyst development GO:0001824 37 22 1,000 0,01911471 0,09046058 ! neural tube closure GO:0001843 33 22 1,000 0,01911471 0,09027483 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 0,01973451 0,09301103 ! lung development GO:0030324 94 59 2,000 0,01973451 0,09282082 ! actin filament organization GO:0007015 95 59 2,000 0,01973451 0,09263139 ! nucleoside monophosphate metabolic process GO:0009123 95 59 2,000 0,01973451 0,09244273 ! glycerolipid biosynthetic process GO:0045017 85 60 2,000 0,02062815 0,0964324 ! regulation of heart contraction GO:0008016 91 60 2,000 0,02062815 0,0962368 ! regulation of homeostatic process GO:0032844 105 60 2,000 0,02062815 0,09604199 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,0208031 0,09666088 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,0208031 0,096466 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,0208031 0,0962719 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,0208031 0,09607858 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,0208031 0,09588604 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,0208031 0,09569427 ! regulation of biomineral formation GO:0070167 31 23 1,000 0,0208031 0,09550326 ! pentose metabolic process GO:0019321 31 23 1,000 0,0208031 0,09531302 ! liver development GO:0001889 40 23 1,000 0,0208031 0,09512353 ! urogenital system development GO:0001655 101 61 2,000 0,02154374 0,09831468 ! respiratory tube development GO:0030323 99 62 2,000 0,02248129 0,10239003 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,02255125 0,10250568 ! initiation of viral infection GO:0019059 42 24 1,000 0,02255125 0,1023035 ! receptor metabolic process GO:0043112 37 24 1,000 0,02255125 0,10210212 ! neural crest cell development GO:0014032 39 24 1,000 0,02255125 0,10190152 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 1,000 0,02255125 0,10170172 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,02255125 0,10150269 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,02255125 0,10130444 ! glutathione metabolic process GO:0006749 29 24 1,000 0,02255125 0,10110697 ! regulation of lipase activity GO:0060191 109 63 2,000 0,02344081 0,10489076 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,02435785 0,10878264 ! male gonad development GO:0008584 33 25 1,000 0,02435785 0,10857182 ! iron ion homeostasis GO:0055072 39 25 1,000 0,02435785 0,10836181 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,02435785 0,10815262 ! leukocyte proliferation GO:0070661 39 25 1,000 0,02435785 0,10794423 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,02435785 0,10773665 ! respiratory system development GO:0060541 100 64 2,000 0,02442228 0,10781429 ! positive regulation of T cell activation GO:0050870 94 65 2,000 0,0254257 0,11202895 ! protein oligomerization GO:0051259 100 65 2,000 0,0254257 0,11181475 ! regulation of pH GO:0006885 36 26 1,000 0,02622162 0,11509488 ! post-embryonic development GO:0009791 42 26 1,000 0,02622162 0,11487565 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 0,02622162 0,11465726 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 2,000 0,0274983 0,12001157 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,0274983 0,11978427 ! GPI anchor biosynthetic process GO:0006506 37 27 1,000 0,02814128 0,12235338 ! acute-phase response GO:0006953 42 27 1,000 0,02814128 0,12212252 ! myofibril assembly GO:0030239 36 27 1,000 0,02814128 0,12189254 GO:0055002|striated muscle cell development, ! lipid oxidation GO:0034440 38 27 1,000 0,02814128 0,12166342 GO:0019395|fatty acid oxidation, ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,02814128 0,12143516 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 0,02814128 0,12120775 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02814128 0,12098119 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,02814128 0,12075548 ! learning or memory GO:0007611 123 68 2,000 0,02856743 0,12235583 ! cytosolic calcium ion homeostasis GO:0051480 107 68 2,000 0,02856743 0,1221284 ! response to drug GO:0042493 108 69 2,000 0,02965838 0,12655711 ! positive regulation of endocytosis GO:0045807 33 28 1,000 0,03011558 0,12827008 ! GPI anchor metabolic process GO:0006505 40 28 1,000 0,03011558 0,12803298 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,03011558 0,12779676 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,03011558 0,12756141 ! neural tube formation GO:0001841 41 28 1,000 0,03011558 0,12732692 ! regulation of B cell activation GO:0050864 42 28 1,000 0,03011558 0,12709329 ! response to metal ion GO:0010038 103 70 2,000 0,03077113 0,12962199 ! regulation of catabolic process GO:0009894 106 70 2,000 0,03077113 0,12938502 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,03214331 0,13490804 ! ovulation cycle process GO:0022602 41 29 1,000 0,03214331 0,13466231 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,03214331 0,13441747 ! muscle cell development GO:0055001 38 29 1,000 0,03214331 0,13417352 ! telencephalon development GO:0021537 52 29 1,000 0,03214331 0,13393045 ! collagen metabolic process GO:0032963 40 30 1,000 0,03422323 0,14233894 ! spliceosome assembly GO:0000245 49 30 1,000 0,03422323 0,14208201 ! ovulation cycle GO:0042698 43 30 1,000 0,03422323 0,14182601 ! hindbrain development GO:0030902 45 30 1,000 0,03422323 0,14157093 ! fatty acid catabolic process GO:0009062 43 30 1,000 0,03422323 0,14131676 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,03422323 0,14106351 ! response to heat GO:0009408 41 30 1,000 0,03422323 0,14081116 ! phospholipid biosynthetic process GO:0008654 102 74 2,000 0,03543897 0,14555291 ! mammary gland development GO:0030879 57 31 1,000 0,03635417 0,14904561 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,03635417 0,1487804 ! segmentation GO:0035282 41 31 1,000 0,03635417 0,14851614 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,03635417 0,14825281 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03635417 0,14799042 ! cell fate specification GO:0001708 37 31 1,000 0,03635417 0,14772895 ! response to inorganic substance GO:0010035 115 75 2,000 0,03665982 0,14870828 ! regulation of protein transport GO:0051223 114 76 2,000 0,03790209 0,15347678 GO:0070201|regulation of establishment of protein localization, ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,03853494 0,15576512 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,03853494 0,15549184 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,03853494 0,15521953 ! peripheral nervous system development GO:0007422 53 32 1,000 0,03853494 0,15494817 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,03853494 0,15467775 ! gland development GO:0048732 148 77 2,000 0,0391657 0,15693571 ! nitrogen compound catabolic process GO:0044270 114 78 2,000 0,04045055 0,16180219 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,04076438 0,16277442 ! phosphoinositide biosynthetic process GO:0046489 47 33 1,000 0,04076438 0,16249232 ! ear morphogenesis GO:0042471 42 33 1,000 0,04076438 0,16221119 ! actomyosin structure organization GO:0031032 43 33 1,000 0,04076438 0,16193103 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,04076438 0,16165184 ! female gonad development GO:0008585 49 33 1,000 0,04076438 0,16137361 ! positive regulation of cell development GO:0010720 54 33 1,000 0,04076438 0,16109634 ! lipid homeostasis GO:0055088 55 33 1,000 0,04076438 0,16082001 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,04076438 0,16054464 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,04076438 0,1602702 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,04304135 0,16893364 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 0,04304135 0,16864585 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,04304135 0,16835904 ! female gamete generation GO:0007292 43 34 1,000 0,04304135 0,1680732 ! isoprenoid metabolic process GO:0006720 46 34 1,000 0,04304135 0,16778833 ! embryonic organ development GO:0048568 45 34 1,000 0,04304135 0,16750442 ! forebrain development GO:0030900 131 80 2,000 0,04308363 0,16738573 ! response to protein stimulus GO:0051789 111 81 2,000 0,04443167 0,17233195 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,04536474 0,17565472 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,04536474 0,1753595 ! pigment metabolic process GO:0042440 61 35 1,000 0,04536474 0,17506528 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04769032 0,18373156 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04769032 0,18342432 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04769032 0,1831181 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04769032 0,1828129 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04769032 0,18250872 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04769032 0,18220555 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04769032 0,18190339 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04769032 0,18160222 ! sleep GO:0030431 11 5 0,000 0,04769032 0,18130205 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04769032 0,18100287 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04769032 0,18070468 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04769032 0,18040747 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04769032 0,18011123 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04769032 0,17981597 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04769032 0,17952167 ! tongue development GO:0043586 6 5 0,000 0,04769032 0,17922834 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04769032 0,17893596 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04769032 0,17864453 ! cobalt ion transport GO:0006824 9 5 0,000 0,04769032 0,17835405 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04769032 0,17806452 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04769032 0,17777592 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04769032 0,17748825 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04769032 0,17720152 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04769032 0,17691571 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04769032 0,17663082 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04769032 0,17634685 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04769032 0,17606379 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04769032 0,17578164 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04769032 0,17550039 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04769032 0,17522003 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04769032 0,17494058 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04769032 0,17466201 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04769032 0,17438433 ! malate metabolic process GO:0006108 7 5 0,000 0,04769032 0,17410753 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04769032 0,1738316 ! behavioral response to pain GO:0048266 7 5 0,000 0,04769032 0,17355655 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04769032 0,17328237 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04769032 0,17300906 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04769032 0,1727366 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04769032 0,172465 ! mating behavior GO:0007617 6 5 0,000 0,04769032 0,17219426 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04769032 0,17192436 ! rhythmic behavior GO:0007622 12 5 0,000 0,04769032 0,17165531 ! copulation GO:0007620 7 5 0,000 0,04769032 0,1713871 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04769032 0,17111972 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04769032 0,17085318 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04769032 0,17058747 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04769032 0,17032258 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04769032 0,17005851 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04769032 0,16979527 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04769032 0,16953283 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04769032 0,16927121 ! response to protozoan GO:0001562 9 5 0,000 0,04769032 0,16901039 ! lymph vessel development GO:0001945 7 5 0,000 0,04769032 0,16875037 ! endochondral ossification GO:0001958 12 5 0,000 0,04769032 0,16849115 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04769032 0,16823273 ! parathyroid gland development GO:0060017 8 5 0,000 0,04769032 0,1679751 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04769032 0,16771826 ! anagen GO:0042640 6 5 0,000 0,04769032 0,1674622 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04769032 0,16720692 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04769032 0,16695242 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04769032 0,1666987 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04769032 0,16644574 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04769032 0,16619355 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04769032 0,16594212 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04769032 0,16569145 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04769032 0,16544154 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04769032 0,16519238 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04769032 0,16494397 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04769032 0,16469631 ! ovulation GO:0030728 6 5 0,000 0,04769032 0,16444939 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04769032 0,16420321 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,04769032 0,16395776 ! response to pH GO:0009268 9 5 0,000 0,04769032 0,16371305 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04769032 0,16346906 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04769032 0,16322581 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04769032 0,16298327 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04769032 0,16274146 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04769032 0,16250036 ! polyol catabolic process GO:0046174 7 5 0,000 0,04769032 0,16225997 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04769032 0,1620203 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04769032 0,16178133 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04769032 0,16154307 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04769032 0,1613055 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04769032 0,16106864 ! urea metabolic process GO:0019627 6 5 0,000 0,04769032 0,16083247 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04769032 0,16059699 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04769032 0,1603622 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04769032 0,16012809 ! neutrophil activation GO:0042119 5 5 0,000 0,04769032 0,15989467 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04769032 0,15966192 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04769032 0,15942986 ! response to food GO:0032094 5 5 0,000 0,04769032 0,15919846 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04769032 0,15896774 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04769032 0,15873769 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04769032 0,1585083 ! forebrain neuron development GO:0021884 7 5 0,000 0,04769032 0,15827957 ! melanosome organization GO:0032438 7 5 0,000 0,04769032 0,1580515 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04769032 0,15782409 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04769032 0,15759733 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04769032 0,15737122 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04769032 0,15714576 GO:0009251|glucan catabolic process, ! nucleoside transport GO:0015858 6 5 0,000 0,04769032 0,15692095 ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04769032 0,15669677 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04769032 0,15647324 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04769032 0,15625034 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04769032 0,15602808 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04769032 0,15580645 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04769032 0,15558545 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04769032 0,15536507 ! depyrimidination GO:0045008 8 5 0,000 0,04769032 0,15514532 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04769032 0,15492619 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04769032 0,15470768 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04769032 0,15448978 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04769032 0,15427249 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04769032 0,15405582 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04769032 0,15383975 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04769032 0,15362429 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04769032 0,15340943 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04769032 0,15319517 ! centrosome duplication GO:0051298 5 5 0,000 0,04769032 0,15298151 ! response to UV-C GO:0010225 6 5 0,000 0,04769032 0,15276844 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04769032 0,15255597 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04769032 0,15234409 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04769032 0,15213279 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04769032 0,15192208 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04769032 0,15171195 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04769032 0,15150241 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04769032 0,15129344 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04769032 0,15108504 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04769032 0,15087722 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04769032 0,15066997 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04769032 0,15046329 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04769032 0,15025718 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04769032 0,15005163 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04769032 0,14984664 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04769032 0,14964221 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04769032 0,14943834 ! neural tube patterning GO:0021532 6 5 0,000 0,04769032 0,14923502 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04769032 0,14903226 ! histone demethylation GO:0016577 9 5 0,000 0,04769032 0,14883004 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04769032 0,14862838 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04769032 0,14842726 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04769032 0,14822668 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04769032 0,14802664 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04769032 0,14782714 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04769032 0,14762819 ! transcription termination GO:0006353 8 5 0,000 0,04769032 0,14742976 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04769032 0,14723187 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04769032 0,14703451 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04769032 0,14683767 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04769032 0,14664137 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04769032 0,14644558 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04769032 0,14625032 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04769032 0,14605558 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04769032 0,14586136 ! apical protein localization GO:0045176 6 5 0,000 0,04769032 0,14566765 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04769032 0,14547446 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04769032 0,14528178 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04769032 0,14508961 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04769032 0,14489794 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04769032 0,14470678 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04769032 0,14451613 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04769032 0,14432598 ! glial cell migration GO:0008347 10 5 0,000 0,04769032 0,14413632 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04769032 0,14394717 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04769032 0,14375851 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04769032 0,14357034 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04769032 0,14338267 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04769032 0,14319549 ! neural plate development GO:0001840 6 5 0,000 0,04769032 0,14300879 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,04769032 0,14282258 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04769032 0,14263686 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04769032 0,14245161 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04769032 0,14226685 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04769032 0,14208257 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04769032 0,14189876 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04769032 0,14171543 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04769032 0,14153257 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04769032 0,14135018 ! spindle assembly GO:0051225 5 5 0,000 0,04769032 0,14116826 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04769032 0,14098681 GO:0022011|myelination in the peripheral nervous system, ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04769032 0,14080583 ! organ regeneration GO:0031100 7 5 0,000 0,04769032 0,14062531 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04769032 0,14044525 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04769032 0,14026565 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04769032 0,14008652 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04769032 0,13990783 GO:0055081|anion homeostasis, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04773343 0,13985592 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,04773343 0,13967798 ! neural tube development GO:0021915 50 36 1,000 0,04773343 0,1395005 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04773343 0,13932347 GO:0046660|female sex differentiation, ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,05003137 0,14584557 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,05003137 0,14566095 ! learning GO:0007612 67 37 1,000 0,05014634 0,1458111 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,05260239 0,15275947 ! monocarboxylic acid transport GO:0015718 62 38 1,000 0,05260239 0,15256683 ! phagocytosis GO:0006909 60 38 1,000 0,05260239 0,15237468 ! maintenance of location in cell GO:0051651 69 38 1,000 0,05260239 0,15218302 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,05444585 0,15731842 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,05510053 0,1590103 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,05510053 0,15881104 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,05510053 0,15861228 ! male sex differentiation GO:0046661 53 39 1,000 0,05510053 0,15841402 ! chromatin remodeling GO:0006338 68 39 1,000 0,05510053 0,15821624 ! developmental growth GO:0048589 62 39 1,000 0,05510053 0,15801897 ! reproductive developmental process GO:0003006 127 89 2,000 0,05595759 0,16027703 ! tRNA transcription GO:0009304 11 6 0,000 0,05695351 0,16292669 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05695351 0,1627243 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,05695351 0,16252241 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05695351 0,16232102 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05695351 0,16212013 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05695351 0,16191973 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05695351 0,16171983 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05695351 0,16152042 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05695351 0,1613215 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05695351 0,16112308 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05695351 0,16092514 ! prostate gland development GO:0030850 9 6 0,000 0,05695351 0,16072768 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05695351 0,16053071 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05695351 0,16033423 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05695351 0,16013822 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05695351 0,15994269 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05695351 0,15974764 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05695351 0,15955306 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05695351 0,15935896 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05695351 0,15916532 ! neuron adhesion GO:0007158 9 6 0,000 0,05695351 0,15897216 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05695351 0,15877947 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05695351 0,15858724 ! signal peptide processing GO:0006465 8 6 0,000 0,05695351 0,15839548 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05695351 0,15820418 ! mRNA stabilization GO:0048255 15 6 0,000 0,05695351 0,15801334 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05695351 0,15782297 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05695351 0,15763305 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05695351 0,15744358 ! opsonization GO:0008228 8 6 0,000 0,05695351 0,15725458 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05695351 0,15706602 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05695351 0,15687792 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05695351 0,15669027 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05695351 0,15650306 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05695351 0,1563163 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05695351 0,15612999 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05695351 0,15594412 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05695351 0,15575869 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05695351 0,15557371 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05695351 0,15538916 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05695351 0,15520505 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05695351 0,15502138 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05695351 0,15483813 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05695351 0,15465533 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05695351 0,15447295 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05695351 0,154291 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05695351 0,15410948 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05695351 0,15392839 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05695351 0,15374773 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05695351 0,15356748 ! thymic T cell selection GO:0045061 12 6 0,000 0,05695351 0,15338766 ! protein lipoylation GO:0009249 10 6 0,000 0,05695351 0,15320826 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05695351 0,15302928 ! drug transport GO:0015893 6 6 0,000 0,05695351 0,15285071 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05695351 0,15267257 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05695351 0,15249483 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05695351 0,15231751 ! histidine metabolic process GO:0006547 6 6 0,000 0,05695351 0,15214061 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05695351 0,15196411 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05695351 0,15178802 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05695351 0,15161234 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05695351 0,15143707 ! adenohypophysis development GO:0021984 10 6 0,000 0,05695351 0,1512622 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05695351 0,15108773 ! hyperosmotic response GO:0006972 8 6 0,000 0,05695351 0,15091367 ! microtubule nucleation GO:0007020 10 6 0,000 0,05695351 0,15074 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05695351 0,15056674 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05695351 0,15039387 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05695351 0,1502214 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05695351 0,15004933 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05695351 0,14987765 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,05695351 0,14970636 ! response to dietary excess GO:0002021 7 6 0,000 0,05695351 0,14953546 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05695351 0,14936495 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05695351 0,14919483 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05695351 0,1490251 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05695351 0,14885575 GO:0046464|acylglycerol catabolic process, ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05695351 0,14868679 ! organic alcohol transport GO:0015850 9 6 0,000 0,05695351 0,14851821 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,05695351 0,14835001 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05695351 0,1481822 ! carnitine transport GO:0015879 8 6 0,000 0,05695351 0,14801476 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05695351 0,1478477 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05695351 0,14768102 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05695351 0,14751471 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05695351 0,14734878 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05695351 0,14718322 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05695351 0,14701803 ! parturition GO:0007567 12 6 0,000 0,05695351 0,14685321 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05695351 0,14668876 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05695351 0,14652468 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05695351 0,14636096 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05695351 0,14619761 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05695351 0,14603463 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05695351 0,14587201 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05695351 0,14570975 ! macrophage differentiation GO:0030225 10 6 0,000 0,05695351 0,14554785 ! astrocyte development GO:0014002 14 6 0,000 0,05695351 0,14538631 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05695351 0,14522512 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05695351 0,1450643 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05695351 0,14490383 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05695351 0,14474371 ! eating behavior GO:0042755 6 6 0,000 0,05695351 0,14458395 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05695351 0,14442454 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05695351 0,14426549 ! response to copper ion GO:0046688 9 6 0,000 0,05695351 0,14410678 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05695351 0,14394842 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,05695351 0,14379041 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05695351 0,14363274 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05695351 0,14347542 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05695351 0,14331845 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05695351 0,14316182 ! gas homeostasis GO:0033483 11 6 0,000 0,05695351 0,14300553 ! hair follicle maturation GO:0048820 7 6 0,000 0,05695351 0,14284958 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05695351 0,14269397 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05695351 0,1425387 ! Schwann cell development GO:0014044 14 6 0,000 0,05695351 0,14238376 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05695351 0,14222917 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05695351 0,1420749 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05695351 0,14192098 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05695351 0,14176738 ! histone ubiquitination GO:0016574 7 6 0,000 0,05695351 0,14161412 ! regulation of meiosis GO:0040020 10 6 0,000 0,05695351 0,14146119 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05695351 0,14130859 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05695351 0,14115632 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05695351 0,14100437 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05695351 0,14085275 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05695351 0,14070146 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05695351 0,1405505 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05695351 0,14039985 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05695351 0,14024953 ! receptor internalization GO:0031623 9 6 0,000 0,05695351 0,14009953 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05695351 0,13994985 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05695351 0,13980049 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05695351 0,13965145 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05695351 0,13950273 ! protein deubiquitination GO:0016579 8 6 0,000 0,05695351 0,13935432 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05695351 0,13920623 ! axonal fasciculation GO:0007413 9 6 0,000 0,05695351 0,13905845 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05695351 0,13891099 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05695351 0,13876384 ! midbrain development GO:0030901 6 6 0,000 0,05695351 0,138617 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05695351 0,13847047 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05695351 0,13832425 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05695351 0,13817834 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05695351 0,13803273 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05695351 0,13788743 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05695351 0,13774244 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05695351 0,13759775 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05695351 0,13745337 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05695351 0,13730929 ! adult feeding behavior GO:0008343 6 6 0,000 0,05695351 0,13716551 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05695351 0,13702203 ! blastocyst growth GO:0001832 15 6 0,000 0,05695351 0,13687885 ! pigment granule transport GO:0051904 12 6 0,000 0,05695351 0,13673597 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05695351 0,13659339 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05695351 0,13645111 ! catecholamine transport GO:0051937 7 6 0,000 0,05695351 0,13630912 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05695351 0,13616742 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05695351 0,13602602 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05695351 0,13588492 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,05695351 0,13574411 ! protein prenylation GO:0018342 10 6 0,000 0,05695351 0,13560358 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05695351 0,13546335 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,05695351 0,13532341 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05695351 0,13518376 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05695351 0,13504439 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05695351 0,13490532 ! response to calcium ion GO:0051592 58 40 1,000 0,05763971 0,13639026 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,05763971 0,13625009 ! peptide metabolic process GO:0006518 56 40 1,000 0,05763971 0,1361102 ! double-strand break repair GO:0006302 67 40 1,000 0,05763971 0,1359706 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,05763971 0,13583128 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,05763971 0,13569226 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,06021892 0,14161913 ! protein amino acid lipidation GO:0006497 62 41 1,000 0,06021892 0,14147447 ! glucose transport GO:0015758 52 41 1,000 0,06021892 0,14133011 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,06021892 0,14118604 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,0622022 0,14568744 ! hexose transport GO:0008645 54 42 1,000 0,06283714 0,14702484 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,06283714 0,14687542 ! icosanoid metabolic process GO:0006690 61 42 1,000 0,06283714 0,14672631 ! regulation of cell shape GO:0008360 78 42 1,000 0,06283714 0,1465775 ! response to oxidative stress GO:0006979 141 94 2,000 0,06381208 0,14870089 ! regulation of binding GO:0051098 151 95 2,000 0,06544115 0,15234277 ! carboxylic acid transport GO:0046942 147 95 2,000 0,06544115 0,15218873 GO:0015849|organic acid transport, ! positive regulation of binding GO:0051099 59 43 1,000 0,06549338 0,15215634 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,06549338 0,1520028 ! vesicle organization GO:0016050 79 43 1,000 0,06549338 0,15184957 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06612711 0,1531645 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06612711 0,15301041 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06612711 0,15285663 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,06612711 0,15270316 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06612711 0,15255 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06612711 0,15239715 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06612711 0,1522446 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06612711 0,15209235 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06612711 0,15194041 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06612711 0,15178877 ! reproductive behavior GO:0019098 12 7 0,000 0,06612711 0,15163744 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06612711 0,15148641 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,06612711 0,15133567 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06612711 0,15118524 ! oligopeptide transport GO:0006857 11 7 0,000 0,06612711 0,15103511 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06612711 0,15088527 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06612711 0,15073573 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06612711 0,15058649 ! RNA methylation GO:0001510 11 7 0,000 0,06612711 0,15043754 ! pericardium development GO:0060039 8 7 0,000 0,06612711 0,15028888 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06612711 0,15014052 ! fibril organization GO:0043206 13 7 0,000 0,06612711 0,14999246 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,06612711 0,14984468 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06612711 0,1496972 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06612711 0,14955 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06612711 0,1494031 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06612711 0,14925648 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06612711 0,14911015 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06612711 0,14896411 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06612711 0,14881835 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06612711 0,14867288 ! chemosensory behavior GO:0007635 9 7 0,000 0,06612711 0,14852769 ! microtubule bundle formation GO:0001578 8 7 0,000 0,06612711 0,14838278 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,06612711 0,14823816 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06612711 0,14809382 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06612711 0,14794976 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06612711 0,14780598 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06612711 0,14766248 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06612711 0,14751925 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06612711 0,14737631 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06612711 0,14723364 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06612711 0,14709125 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06612711 0,14694913 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06612711 0,14680729 ! spinal cord patterning GO:0021511 7 7 0,000 0,06612711 0,14666572 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,06612711 0,14652442 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06612711 0,1463834 ! adrenal gland development GO:0030325 17 7 0,000 0,06612711 0,14624265 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06612711 0,14610216 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06612711 0,14596195 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06612711 0,14582201 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! proline metabolic process GO:0006560 8 7 0,000 0,06612711 0,14568233 ! endosome organization GO:0007032 10 7 0,000 0,06612711 0,14554292 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06612711 0,14540378 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06612711 0,1452649 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06612711 0,14512629 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06612711 0,14498794 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06612711 0,14484986 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06612711 0,14471204 ! galactose metabolic process GO:0006012 10 7 0,000 0,06612711 0,14457448 ! vesicle fusion GO:0006906 15 7 0,000 0,06612711 0,14443718 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06612711 0,14430014 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,06612711 0,14416337 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06612711 0,14402685 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06612711 0,14389059 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06612711 0,14375459 ! retinol metabolic process GO:0042572 9 7 0,000 0,06612711 0,14361884 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06612711 0,14348335 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06612711 0,14334812 ! rRNA modification GO:0000154 12 7 0,000 0,06612711 0,14321314 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06612711 0,14307841 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06612711 0,14294394 ! intermediate filament organization GO:0045109 11 7 0,000 0,06612711 0,14280972 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06612711 0,14267575 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06612711 0,14254203 ! fibrinolysis GO:0042730 9 7 0,000 0,06612711 0,14240857 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06612711 0,14227535 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06612711 0,14214238 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06612711 0,14200967 ! response to tropane GO:0014073 13 7 0,000 0,06612711 0,14187719 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! melanosome localization GO:0032400 10 7 0,000 0,06612711 0,14174497 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06612711 0,14161299 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06612711 0,14148126 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06612711 0,14134977 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06612711 0,14121852 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06612711 0,14108752 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06612711 0,14095677 ! mast cell activation GO:0045576 9 7 0,000 0,06612711 0,14082625 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06612711 0,14069598 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06612711 0,14056594 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06612711 0,14043615 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,06612711 0,1403066 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06612711 0,14017728 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06612711 0,14004821 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06612711 0,13991937 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06612711 0,13979076 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06612711 0,1396624 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06612711 0,13953427 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06612711 0,13940637 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06612711 0,13927871 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06612711 0,13915128 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06612711 0,13902409 ! diuresis GO:0030146 12 7 0,000 0,06612711 0,13889712 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06612711 0,13877039 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06612711 0,13864389 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06612711 0,13851762 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06612711 0,13839158 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06612711 0,13826577 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06612711 0,13814019 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06612711 0,13801484 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06612711 0,13788971 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06612711 0,13776481 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06612711 0,13764014 ! lymph node development GO:0048535 9 7 0,000 0,06612711 0,13751569 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06612711 0,13739146 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06612711 0,13726747 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06612711 0,13714369 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06612711 0,13702014 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06612711 0,13689681 ! ATP catabolic process GO:0006200 10 7 0,000 0,06612711 0,1367737 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06612711 0,13665081 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06612711 0,13652814 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06612711 0,1364057 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06612711 0,13628347 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06612711 0,13616146 ! muscle adaptation GO:0043500 12 7 0,000 0,06612711 0,13603967 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06612711 0,1359181 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06612711 0,13579674 ! retina homeostasis GO:0001895 9 7 0,000 0,06612711 0,1356756 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06612711 0,13555468 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06612711 0,13543397 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06612711 0,13531348 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06612711 0,1351932 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06612711 0,13507314 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06612711 0,13495328 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06612711 0,13483364 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,06708928 0,13667435 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,06818667 0,13878703 ! ribonucleoprotein complex assembly GO:0022618 70 44 1,000 0,06818667 0,13866432 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,06818667 0,13854182 ! lipoprotein biosynthetic process GO:0042158 67 45 1,000 0,07091604 0,1439602 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,07368055 0,14944028 ! histone modification GO:0016570 68 46 1,000 0,07368055 0,14930861 ! regulation of translation GO:0006417 151 100 2,000 0,07386921 0,14955914 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,07386921 0,14942761 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,075212 0,15201018 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,075212 0,15187673 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,075212 0,1517435 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,075212 0,15161051 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,075212 0,15147775 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,075212 0,15134522 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,075212 0,15121293 ! phosphate transport GO:0006817 10 8 0,000 0,075212 0,15108086 ! N-glycan processing GO:0006491 12 8 0,000 0,075212 0,15094903 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,075212 0,15081743 ! UTP metabolic process GO:0046051 8 8 0,000 0,075212 0,15068605 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,075212 0,15055491 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,075212 0,15042399 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,075212 0,1502933 ! succinate metabolic process GO:0006105 14 8 0,000 0,075212 0,15016284 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,075212 0,1500326 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,075212 0,14990259 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,075212 0,14977281 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,075212 0,14964324 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,075212 0,14951391 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,075212 0,14938479 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,075212 0,1492559 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,075212 0,14912723 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,075212 0,14899879 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,075212 0,14887056 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,075212 0,14874255 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,075212 0,14861477 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,075212 0,1484872 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,075212 0,14835985 ! astrocyte differentiation GO:0048708 16 8 0,000 0,075212 0,14823273 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,075212 0,14810581 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,075212 0,14797912 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,075212 0,14785264 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,075212 0,14772638 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,075212 0,14760033 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,075212 0,1474745 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,075212 0,14734888 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,075212 0,14722348 ! macrophage activation GO:0042116 12 8 0,000 0,075212 0,14709829 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,075212 0,14697331 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,075212 0,14684855 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,075212 0,146724 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,075212 0,14659965 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,075212 0,14647552 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,075212 0,1463516 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,075212 0,14622789 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,075212 0,14610438 ! ruffle organization GO:0031529 11 8 0,000 0,075212 0,14598109 ! osteoblast development GO:0002076 13 8 0,000 0,075212 0,145858 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,075212 0,14573512 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,075212 0,14561245 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,075212 0,14548998 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,075212 0,14536772 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,075212 0,14524567 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,075212 0,14512382 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,075212 0,14500217 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,075212 0,14488073 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,075212 0,14475949 ! brain morphogenesis GO:0048854 20 8 0,000 0,075212 0,14463845 ! oligodendrocyte development GO:0014003 8 8 0,000 0,075212 0,14451762 ! segment specification GO:0007379 10 8 0,000 0,075212 0,14439699 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,075212 0,14427656 ! cellular extravasation GO:0045123 11 8 0,000 0,075212 0,14415633 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,075212 0,14403629 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,075212 0,14391646 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,075212 0,14379683 ! snRNA metabolic process GO:0016073 10 8 0,000 0,075212 0,1436774 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,075212 0,14355817 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,075212 0,14343913 ! nucleosome disassembly GO:0006337 12 8 0,000 0,075212 0,14332029 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,075212 0,14320165 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,075212 0,1430832 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,075212 0,14296495 ! icosanoid secretion GO:0032309 12 8 0,000 0,075212 0,1428469 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,075212 0,14272903 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,075212 0,14261137 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,075212 0,1424939 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,075212 0,14237662 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,075212 0,14225953 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,075212 0,14214264 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,075212 0,14202594 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,075212 0,14190943 ! sterol catabolic process GO:0016127 9 8 0,000 0,075212 0,14179311 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,075212 0,14167698 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,075212 0,14156104 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,075212 0,14144529 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,075212 0,14132973 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,075212 0,14121436 ! prophase GO:0051324 11 8 0,000 0,075212 0,14109918 ! S phase GO:0051320 8 8 0,000 0,075212 0,14098418 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,075212 0,14086937 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,075212 0,14075475 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,075212 0,14064032 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,075212 0,14052607 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,075212 0,140412 ! hormone catabolic process GO:0042447 13 8 0,000 0,075212 0,14029813 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,075212 0,14018443 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,075212 0,14007092 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,075212 0,1399576 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,075212 0,13984445 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,075212 0,13973149 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,075212 0,13961872 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,075212 0,13950612 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,075212 0,13939371 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,075212 0,13928147 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,075212 0,13916942 ! lamellipodium assembly GO:0030032 9 8 0,000 0,075212 0,13905755 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,075212 0,13894586 GO:0000076|DNA replication checkpoint, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,075212 0,13883434 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,07647927 0,1410604 ! covalent chromatin modification GO:0016569 75 47 1,000 0,07647927 0,14094737 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,07647927 0,14083452 ! chloride transport GO:0006821 67 48 1,000 0,07931127 0,14593274 ! response to temperature stimulus GO:0009266 62 48 1,000 0,07931127 0,14581609 ! heart morphogenesis GO:0003007 65 48 1,000 0,07931127 0,14569962 ! regulation of endocytosis GO:0030100 63 48 1,000 0,07931127 0,14558334 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,08217566 0,1507209 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,08217566 0,15060081 ! germ cell development GO:0007281 68 49 1,000 0,08217566 0,1504809 ! maintenance of location GO:0051235 84 49 1,000 0,08217566 0,15036119 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,08420902 0,15395925 ! telencephalon cell migration GO:0022029 16 9 0,000 0,08420902 0,15383697 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,08420902 0,15371487 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,08420902 0,15359297 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,08420902 0,15347127 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,08420902 0,15334975 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,08420902 0,15322843 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,08420902 0,1531073 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,08420902 0,15298637 ! GTP metabolic process GO:0046039 9 9 0,000 0,08420902 0,15286562 ! elastic fiber assembly GO:0048251 13 9 0,000 0,08420902 0,15274506 ! social behavior GO:0035176 14 9 0,000 0,08420902 0,1526247 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,08420902 0,15250452 ! artery development GO:0060840 19 9 0,000 0,08420902 0,15238453 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,08420902 0,15226473 ! response to pain GO:0048265 16 9 0,000 0,08420902 0,15214512 ! protein complex disassembly GO:0043241 17 9 0,000 0,08420902 0,1520257 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,08420902 0,15190646 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,08420902 0,15178741 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,08420902 0,15166855 ! lung alveolus development GO:0048286 17 9 0,000 0,08420902 0,15154988 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,08420902 0,15143138 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,08420902 0,15131308 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,08420902 0,15119496 ! ventral spinal cord development GO:0021517 11 9 0,000 0,08420902 0,15107702 ! protein targeting to ER GO:0045047 19 9 0,000 0,08420902 0,15095927 ! endoderm development GO:0007492 12 9 0,000 0,08420902 0,1508417 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,08420902 0,15072431 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,08420902 0,15060711 ! arginine catabolic process GO:0006527 10 9 0,000 0,08420902 0,15049009 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,08420902 0,15037325 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,08420902 0,15025659 GO:0010833|telomere maintenance via telomere lengthening, ! phosphagen metabolic process GO:0006599 12 9 0,000 0,08420902 0,15014011 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,08420902 0,15002381 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,08420902 0,14990769 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,08420902 0,14979176 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,08420902 0,149676 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,08420902 0,14956042 ! mannose metabolic process GO:0006013 9 9 0,000 0,08420902 0,14944502 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,08420902 0,14932979 ! receptor clustering GO:0043113 15 9 0,000 0,08420902 0,14921475 ! epithelial cell development GO:0002064 10 9 0,000 0,08420902 0,14909988 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,08420902 0,14898519 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,08420902 0,14887067 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,08420902 0,14875633 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,08420902 0,14864216 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,08420902 0,14852818 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,08420902 0,14841436 ! blastoderm segmentation GO:0007350 11 9 0,000 0,08420902 0,14830072 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,08420902 0,14818725 ! response to amine stimulus GO:0014075 13 9 0,000 0,08420902 0,14807396 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,08420902 0,14796084 ! erythrocyte development GO:0048821 11 9 0,000 0,08420902 0,14784789 ! renal water homeostasis GO:0003091 14 9 0,000 0,08420902 0,14773512 ! postreplication repair GO:0006301 11 9 0,000 0,08420902 0,14762252 ! mRNA cleavage GO:0006379 13 9 0,000 0,08420902 0,14751008 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,08420902 0,14739782 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,08420902 0,14728573 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,08420902 0,14717381 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,08420902 0,14706207 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,08420902 0,14695049 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,08420902 0,14683908 ! acid secretion GO:0046717 14 9 0,000 0,08420902 0,14672783 ! musculoskeletal movement GO:0050881 11 9 0,000 0,08420902 0,14661676 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,08420902 0,14650586 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,08420902 0,14639512 ! purine base metabolic process GO:0006144 18 9 0,000 0,08420902 0,14628455 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,08420902 0,14617414 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,08420902 0,14606391 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,08420902 0,14595384 ! detection of calcium ion GO:0005513 13 9 0,000 0,08420902 0,14584393 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,08420902 0,14573419 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,08420902 0,14562462 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,08420902 0,14551521 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,08420902 0,14540596 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,08420902 0,14529688 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,08420902 0,14518796 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,08420902 0,14507921 ! prepulse inhibition GO:0060134 14 9 0,000 0,08420902 0,14497061 ! embryonic placenta development GO:0001892 12 9 0,000 0,08420902 0,14486218 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,08420902 0,14475392 ! insulin secretion GO:0030073 17 9 0,000 0,08420902 0,14464581 ! sequestering of metal ion GO:0051238 11 9 0,000 0,08420902 0,14453787 ! establishment of cell polarity GO:0030010 12 9 0,000 0,08420902 0,14443008 ! nucleus localization GO:0051647 15 9 0,000 0,08420902 0,14432246 ! regulation of synapse organization GO:0050807 12 9 0,000 0,08420902 0,144215 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,08799805 0,15059189 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,09311902 0,15923699 ! neuron fate specification GO:0048665 11 10 0,000 0,09311902 0,15911868 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,09311902 0,15900055 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,09311902 0,1588826 ! thyroid gland development GO:0030878 19 10 0,000 0,09311902 0,15876482 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,09311902 0,15864722 ! synapsis GO:0007129 13 10 0,000 0,09311902 0,15852979 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,09311902 0,15841253 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,09311902 0,15829545 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,09311902 0,15817854 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,09311902 0,1580618 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,09311902 0,15794524 ! androgen metabolic process GO:0008209 13 10 0,000 0,09311902 0,15782885 ! phospholipid efflux GO:0033700 16 10 0,000 0,09311902 0,15771263 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,09311902 0,15759657 ! blood vessel remodeling GO:0001974 21 10 0,000 0,09311902 0,1574807 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,09311902 0,15736499 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,09311902 0,15724945 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,09311902 0,15713408 ! pathogenesis GO:0009405 13 10 0,000 0,09311902 0,15701887 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,09311902 0,15690384 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,09311902 0,15678898 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,09311902 0,15667428 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,09311902 0,15655976 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,09311902 0,15644539 ! melanocyte differentiation GO:0030318 15 10 0,000 0,09311902 0,1563312 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,09311902 0,15621717 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,09311902 0,15610331 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,09311902 0,15598962 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,09311902 0,15587609 ! forebrain cell migration GO:0021885 17 10 0,000 0,09311902 0,15576272 ! lipid digestion GO:0044241 15 10 0,000 0,09311902 0,15564952 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,09311902 0,15553649 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,09311902 0,15542362 ! UV protection GO:0009650 14 10 0,000 0,09311902 0,15531091 ! entry into host cell GO:0030260 20 10 0,000 0,09311902 0,15519837 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,09311902 0,15508599 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,09311902 0,15497377 ! regulation of bone resorption GO:0045124 24 10 0,000 0,09311902 0,15486171 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,09311902 0,15474982 ! regulation of organ growth GO:0046620 11 10 0,000 0,09311902 0,15463808 ! response to dsRNA GO:0043331 18 10 0,000 0,09311902 0,15452651 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,09311902 0,1544151 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,09311902 0,15430385 ! embryonic axis specification GO:0000578 12 10 0,000 0,09311902 0,15419276 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,09311902 0,15408183 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,09311902 0,15397106 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,09311902 0,15386045 ! cranial nerve development GO:0021545 12 10 0,000 0,09311902 0,15375 ! fucose catabolic process GO:0019317 16 10 0,000 0,09311902 0,1536397 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,09311902 0,15352957 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,09311902 0,15341959 ! protein sumoylation GO:0016925 12 10 0,000 0,09311902 0,15330977 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,09311902 0,1532001 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,09311902 0,1530906 ! zymogen activation GO:0031638 14 10 0,000 0,09311902 0,15298125 ! salivary gland development GO:0007431 22 10 0,000 0,09311902 0,15287205 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,09311902 0,15276301 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,09311902 0,15265413 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,09311902 0,1525454 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,09311902 0,15243683 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,09311902 0,15232841 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,09311902 0,15222015 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,09311902 0,15211204 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,09311902 0,15200408 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,09311902 0,15189627 ! detection of bacterium GO:0016045 10 10 0,000 0,09311902 0,15178862 ! activation of innate immune response GO:0002218 10 10 0,000 0,09311902 0,15168112 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,09311902 0,15157378 ! developmental induction GO:0031128 13 10 0,000 0,09311902 0,15146658 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,09311902 0,15135954 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,09311902 0,15125265 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,09311902 0,1511459 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,09311902 0,15103931 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,09393949 0,15226273 ! amino acid transport GO:0006865 84 54 1,000 0,09695274 0,15703613 ! regulation of mitosis GO:0007088 84 54 1,000 0,09695274 0,15692562 GO:0051783|regulation of nuclear division, ! detection of external stimulus GO:0009581 66 54 1,000 0,09695274 0,15681527 ! mesoderm development GO:0007498 76 55 1,000 0,09999326 0,16161946 ! rRNA transcription GO:0009303 17 11 0,000 0,10194284 0,16465487 ! respiratory burst GO:0045730 14 11 0,000 0,10194284 0,16453932 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,10194284 0,16442393 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,10194284 0,16430871 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,10194284 0,16419365 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,10194284 0,16407875 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,10194284 0,16396401 ! RNA polyadenylation GO:0043631 19 11 0,000 0,10194284 0,16384943 ! mating GO:0007618 14 11 0,000 0,10194284 0,16373501 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,10194284 0,16362075 ! T cell proliferation GO:0042098 20 11 0,000 0,10194284 0,16350665 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,10194284 0,1633927 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,10194284 0,16327892 ! bone resorption GO:0045453 16 11 0,000 0,10194284 0,1631653 ! regulated secretory pathway GO:0045055 14 11 0,000 0,10194284 0,16305183 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,10194284 0,16293852 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,10194284 0,16282537 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,10194284 0,16271237 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,10194284 0,16259953 ! syncytium formation GO:0006949 15 11 0,000 0,10194284 0,16248685 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,10194284 0,16237433 ! mitotic spindle organization GO:0007052 15 11 0,000 0,10194284 0,16226196 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,10194284 0,16214974 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,10194284 0,16203768 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,10194284 0,16192578 ! adult heart development GO:0007512 11 11 0,000 0,10194284 0,16181403 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,10194284 0,16170243 ! temperature homeostasis GO:0001659 16 11 0,000 0,10194284 0,16159099 ! L-glutamate transport GO:0015813 16 11 0,000 0,10194284 0,1614797 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,10194284 0,16136857 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,10194284 0,16125759 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,10194284 0,16114676 ! stem cell development GO:0048864 29 11 0,000 0,10194284 0,16103608 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,10194284 0,16092555 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,10194284 0,16081518 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,10194284 0,16070495 ! vasoconstriction GO:0042310 15 11 0,000 0,10194284 0,16059488 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,10194284 0,16048496 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,10194284 0,16037519 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,10194284 0,16026557 ! ribosome assembly GO:0042255 13 11 0,000 0,10194284 0,1601561 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,10194284 0,16004678 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,10194284 0,15993761 ! chromatin silencing GO:0006342 19 11 0,000 0,10194284 0,15982858 ! nucleosome positioning GO:0016584 13 11 0,000 0,10194284 0,15971971 ! regulation of isotype switching GO:0045191 19 11 0,000 0,10194284 0,15961098 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,10194284 0,1595024 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,10194284 0,15939397 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,10194284 0,15928569 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,10194284 0,15917755 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,10194284 0,15906956 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,10194284 0,15896171 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,10194284 0,15885402 ! male genitalia development GO:0030539 13 11 0,000 0,10194284 0,15874647 ! cholesterol efflux GO:0033344 19 11 0,000 0,10194284 0,15863906 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,10194284 0,1585318 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,10194284 0,15842468 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,10194284 0,15831771 ! defense response to fungus GO:0050832 12 11 0,000 0,10194284 0,15821088 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,10194284 0,1581042 ! lysogeny GO:0030069 18 11 0,000 0,10194284 0,15799766 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,10194284 0,15789127 ! acrosome reaction GO:0007340 13 11 0,000 0,10194284 0,15778501 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,10194284 0,1576789 ! carbohydrate transport GO:0008643 74 57 1,000 0,10615285 0,16408035 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,10615285 0,16397016 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,10615285 0,16386011 ! gonad development GO:0008406 79 57 1,000 0,10615285 0,16375021 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,10927035 0,16844626 ! lactation GO:0007595 20 12 0,000 0,1106813 0,17050703 ! reproductive cellular process GO:0048610 14 12 0,000 0,1106813 0,1703929 ! tRNA modification GO:0006400 14 12 0,000 0,1106813 0,17027893 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,1106813 0,17016511 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,1106813 0,17005143 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,1106813 0,16993792 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,1106813 0,16982455 ! non-recombinational repair GO:0000726 19 12 0,000 0,1106813 0,16971133 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,1106813 0,16959827 ! peroxisomal transport GO:0043574 21 12 0,000 0,1106813 0,16948535 ! cartilage condensation GO:0001502 18 12 0,000 0,1106813 0,16937259 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,1106813 0,16925997 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,1106813 0,16914751 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,1106813 0,16903519 ! heart looping GO:0001947 15 12 0,000 0,1106813 0,16892302 ! palate development GO:0060021 15 12 0,000 0,1106813 0,16881101 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,1106813 0,16869914 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,1106813 0,16858742 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,1106813 0,16847584 ! arginine metabolic process GO:0006525 13 12 0,000 0,1106813 0,16836442 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,1106813 0,16825314 ! methionine metabolic process GO:0006555 13 12 0,000 0,1106813 0,16814201 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,1106813 0,16803102 ! Golgi organization GO:0007030 18 12 0,000 0,1106813 0,16792018 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,1106813 0,16780949 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,1106813 0,16769894 ! monoamine transport GO:0015844 13 12 0,000 0,1106813 0,16758854 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,1106813 0,16747829 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,1106813 0,16736818 ! L-amino acid transport GO:0015807 20 12 0,000 0,1106813 0,16725821 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,1106813 0,16714839 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,1106813 0,16703871 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,1106813 0,16692918 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,1106813 0,16681979 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,1106813 0,16671054 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,1106813 0,16660144 ! cerebellum development GO:0021549 13 12 0,000 0,1106813 0,16649248 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,1106813 0,16638366 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,1106813 0,16627498 ! histone methylation GO:0016571 15 12 0,000 0,1106813 0,16616645 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,1106813 0,16605805 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,1106813 0,1659498 ! regulation of epidermis development GO:0045682 17 12 0,000 0,1106813 0,16584169 ! intestinal absorption GO:0050892 19 12 0,000 0,1106813 0,16573372 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,1106813 0,16562589 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,1106813 0,1655182 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,1106813 0,16541066 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,1106813 0,16530325 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,1106813 0,16519598 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,1106813 0,16508884 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,1106813 0,16498185 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,1106813 0,164875 ! response to cold GO:0009409 14 12 0,000 0,1106813 0,16476828 ! activation of MAPK activity GO:0000187 84 59 1,000 0,11241196 0,16723643 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,11241196 0,16712832 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,11557692 0,17172282 ! meiosis GO:0007126 96 61 1,000 0,11876449 0,17634495 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,11876449 0,17623117 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,11876449 0,17611755 ! extracellular matrix organization GO:0030198 103 61 1,000 0,11876449 0,17600407 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,11876449 0,17589074 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,11933523 0,17662229 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11933523 0,17650871 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11933523 0,17639527 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,11933523 0,17628198 ! water transport GO:0006833 17 13 0,000 0,11933523 0,17616883 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11933523 0,17605583 ! lipid localization GO:0010876 24 13 0,000 0,11933523 0,17594297 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11933523 0,17583026 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11933523 0,1757177 ! organelle fusion GO:0048284 28 13 0,000 0,11933523 0,17560527 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11933523 0,17549299 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11933523 0,17538086 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,11933523 0,17526886 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11933523 0,17515701 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11933523 0,17504531 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,11933523 0,17493374 ! glutamate metabolic process GO:0006536 18 13 0,000 0,11933523 0,17482232 ! cytokine metabolic process GO:0042107 17 13 0,000 0,11933523 0,17471104 ! NAD metabolic process GO:0019674 21 13 0,000 0,11933523 0,1745999 ! exocrine system development GO:0035272 27 13 0,000 0,11933523 0,1744889 ! bone mineralization GO:0030282 15 13 0,000 0,11933523 0,17437804 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11933523 0,17426733 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11933523 0,17415675 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11933523 0,17404632 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11933523 0,17393602 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11933523 0,17382586 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,11933523 0,17371585 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,11933523 0,17360597 ! genitalia development GO:0048806 15 13 0,000 0,11933523 0,17349623 ! tissue regeneration GO:0042246 21 13 0,000 0,11933523 0,17338663 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11933523 0,17327717 ! cofactor transport GO:0051181 19 13 0,000 0,11933523 0,17316785 ! NADP metabolic process GO:0006739 18 13 0,000 0,11933523 0,17305866 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11933523 0,17294962 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11933523 0,17284071 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11933523 0,17273193 ! gas transport GO:0015669 18 13 0,000 0,11933523 0,1726233 ! regulation of RNA stability GO:0043487 28 13 0,000 0,11933523 0,1725148 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11933523 0,17240643 ! regulation of axon extension GO:0030516 23 13 0,000 0,11933523 0,1722982 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,11933523 0,17219011 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11933523 0,17208216 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11933523 0,17197434 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11933523 0,17186665 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11933523 0,1717591 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,12197393 0,17544717 ! meiotic cell cycle GO:0051321 97 62 1,000 0,12197393 0,17533752 ! organelle localization GO:0051640 96 62 1,000 0,12197393 0,175228 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,12520452 0,1797568 GO:0090046|regulation of transcription regulator activity, ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,12790545 0,18351998 ! superoxide anion generation GO:0042554 18 14 0,000 0,12790545 0,18340556 ! regulation of S phase GO:0033261 18 14 0,000 0,12790545 0,18329129 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,12790545 0,18317716 ! myotube differentiation GO:0014902 21 14 0,000 0,12790545 0,18306318 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,12790545 0,18294933 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,12790545 0,18283563 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,12790545 0,18272206 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,12790545 0,18260864 ! gene silencing by RNA GO:0031047 20 14 0,000 0,12790545 0,18249536 ! response to cAMP GO:0051591 19 14 0,000 0,12790545 0,18238222 ! startle response GO:0001964 21 14 0,000 0,12790545 0,18226922 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,12790545 0,18215636 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,12790545 0,18204364 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,12790545 0,18193106 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,12790545 0,18181862 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,12790545 0,18170632 ! glycine metabolic process GO:0006544 22 14 0,000 0,12790545 0,18159415 ! pituitary gland development GO:0021983 23 14 0,000 0,12790545 0,18148212 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,12790545 0,18137024 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,12790545 0,18125849 ! regulation of heart rate GO:0002027 23 14 0,000 0,12790545 0,18114687 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,12790545 0,1810354 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,12790545 0,18092406 ! embryo implantation GO:0007566 27 14 0,000 0,12790545 0,18081286 ! intermediate filament-based process GO:0045103 24 14 0,000 0,12790545 0,1807018 ! axon cargo transport GO:0008088 27 14 0,000 0,12790545 0,18059087 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,12790545 0,18048008 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,12790545 0,18036942 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,12790545 0,1802589 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,12790545 0,18014851 ! mRNA splice site selection GO:0006376 26 14 0,000 0,12790545 0,18003826 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,12790545 0,17992815 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,12790545 0,17981817 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,12790545 0,17970832 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,12790545 0,17959861 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,12790545 0,17948903 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,12790545 0,17937959 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,12790545 0,17927028 ! muscle maintenance GO:0046716 19 14 0,000 0,12790545 0,1791611 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,12790545 0,17905205 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,12790545 0,17894314 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,12790545 0,17883436 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,12790545 0,17872571 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,12790545 0,1786172 ! cilium assembly GO:0042384 20 14 0,000 0,12790545 0,17850881 ! peptide hormone secretion GO:0030072 23 14 0,000 0,12790545 0,17840056 ! neuropeptide signaling pathway GO:0007218 79 64 1,000 0,12845556 0,17905927 ! reproductive structure development GO:0048608 90 65 1,000 0,13172635 0,18350733 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,13172635 0,18339625 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,13172635 0,1832853 ! axon guidance GO:0007411 99 66 1,000 0,1350162 0,18774926 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,13639274 0,18954882 ! positive regulation of cell size GO:0045793 20 15 0,000 0,13639274 0,18943436 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,13639274 0,18932004 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,13639274 0,18920585 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,13639274 0,1890918 ! skin development GO:0043588 25 15 0,000 0,13639274 0,18897789 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,13639274 0,18886412 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,13639274 0,18875048 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,13639274 0,18863698 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,13639274 0,18852362 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,13639274 0,18841039 ! adult walking behavior GO:0007628 25 15 0,000 0,13639274 0,1882973 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,13639274 0,18818435 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,13639274 0,18807152 ! myoblast differentiation GO:0045445 27 15 0,000 0,13639274 0,18795884 ! centrosome cycle GO:0007098 16 15 0,000 0,13639274 0,18784629 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,13639274 0,18773387 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,13639274 0,18762159 ! cerebral cortex development GO:0021987 29 15 0,000 0,13639274 0,18750945 ! response to osmotic stress GO:0006970 22 15 0,000 0,13639274 0,18739743 ! vesicle coating GO:0006901 25 15 0,000 0,13639274 0,18728555 ! DNA integration GO:0015074 22 15 0,000 0,13639274 0,18717381 ! peptide secretion GO:0002790 27 15 0,000 0,13639274 0,1870622 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,13639274 0,18695072 ! regulation of vasodilation GO:0042312 24 15 0,000 0,13639274 0,18683937 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,13639274 0,18672816 ! neuron recognition GO:0008038 22 15 0,000 0,13639274 0,18661708 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,13639274 0,18650613 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,13639274 0,18639531 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,13639274 0,18628462 ! biomineral formation GO:0031214 18 15 0,000 0,13639274 0,18617407 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,13639274 0,18606364 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,13639274 0,18595335 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,13639274 0,18584319 ! dopamine metabolic process GO:0042417 30 15 0,000 0,13639274 0,18573316 ! organic cation transport GO:0015695 19 15 0,000 0,13639274 0,18562326 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,13639274 0,18551349 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,13639274 0,18540384 ! peptide hormone processing GO:0016486 19 15 0,000 0,13639274 0,18529433 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,13639274 0,18518495 ! acute inflammatory response GO:0002526 92 68 1,000 0,14165042 0,19221001 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,14165042 0,19209667 ! rhythmic process GO:0048511 105 68 1,000 0,14165042 0,19198348 ! inorganic anion transport GO:0015698 93 68 1,000 0,14165042 0,19187041 ! protein secretion GO:0009306 27 16 0,000 0,14479792 0,19601837 ! hormone secretion GO:0046879 25 16 0,000 0,14479792 0,19590307 ! bone remodeling GO:0046849 24 16 0,000 0,14479792 0,1957879 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,14479792 0,19567286 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,14479792 0,19555796 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,14479792 0,1954432 ! glial cell development GO:0021782 24 16 0,000 0,14479792 0,19532857 ! patterning of blood vessels GO:0001569 24 16 0,000 0,14479792 0,19521407 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,14479792 0,19509971 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,14479792 0,19498549 ! protein polyubiquitination GO:0000209 26 16 0,000 0,14479792 0,19487139 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,14479792 0,19475743 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,14479792 0,19464361 ! fructose metabolic process GO:0006000 20 16 0,000 0,14479792 0,19452991 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,14479792 0,19441635 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,14479792 0,19430292 ! protein export from nucleus GO:0006611 24 16 0,000 0,14479792 0,19418963 ! negative regulation of immune response GO:0050777 28 16 0,000 0,14479792 0,19407646 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,14479792 0,19396343 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,14479792 0,19385053 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,14479792 0,19373776 ! diencephalon development GO:0021536 25 16 0,000 0,14479792 0,19362512 ! G1 phase GO:0051318 27 16 0,000 0,14479792 0,19351262 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,14479792 0,19340024 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,14479792 0,19328799 ! steroid catabolic process GO:0006706 22 16 0,000 0,14479792 0,19317588 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,14479792 0,19306389 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,14479792 0,19295203 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,14479792 0,19284031 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,14479792 0,19272871 ! sperm-egg recognition GO:0035036 16 16 0,000 0,14479792 0,19261724 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,14479792 0,1925059 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,14479792 0,19239469 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,14479792 0,19228361 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,14499346 0,19243218 ! humoral immune response GO:0006959 86 70 1,000 0,14835294 0,19677726 ! amine transport GO:0015837 101 70 1,000 0,14835294 0,19666384 ! muscle cell differentiation GO:0042692 104 71 1,000 0,15172823 0,20102242 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,15172823 0,20090669 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,15312177 0,20263525 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,15312177 0,20251873 ! negative regulation of defense response GO:0031348 19 17 0,000 0,15312177 0,20240234 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,15312177 0,20228608 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,15312177 0,20216996 ! glycerol metabolic process GO:0006071 20 17 0,000 0,15312177 0,20205397 ! zinc ion transport GO:0006829 20 17 0,000 0,15312177 0,20193811 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,15312177 0,20182239 ! signal complex assembly GO:0007172 29 17 0,000 0,15312177 0,2017068 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,15312177 0,20159134 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,15312177 0,20147601 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,15312177 0,20136081 ! retinoid metabolic process GO:0001523 22 17 0,000 0,15312177 0,20124575 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,15312177 0,20113082 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,15312177 0,20101602 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,15312177 0,20090135 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,15312177 0,20078681 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,15312177 0,2006724 ! membrane budding GO:0006900 29 17 0,000 0,15312177 0,20055812 ! heme metabolic process GO:0042168 27 17 0,000 0,15312177 0,20044398 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,15312177 0,20032996 ! body fluid secretion GO:0007589 27 17 0,000 0,15312177 0,20021607 ! stem cell differentiation GO:0048863 36 17 0,000 0,15312177 0,20010231 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,15312177 0,19998868 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,15312177 0,19987518 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,15312177 0,19976181 ! sensory perception of pain GO:0019233 23 17 0,000 0,15312177 0,19964856 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,15312177 0,19953545 GO:0002712|regulation of B cell mediated immunity, ! synaptogenesis GO:0007416 24 17 0,000 0,15312177 0,19942246 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,15312177 0,1993096 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,15312177 0,19919687 ! cell-cell junction organization GO:0045216 25 17 0,000 0,15312177 0,19908427 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,15312177 0,19897179 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,15312177 0,19885944 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,15312177 0,19874722 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,15312177 0,19863512 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,1551187 0,20111218 ! regulation of blood pressure GO:0008217 107 73 1,000 0,15852374 0,20541105 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,15852374 0,20529539 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,15852374 0,20517986 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,16136507 0,20873997 ! positive regulation of translation GO:0045727 28 18 0,000 0,16136507 0,20862263 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,16136507 0,20850543 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,16136507 0,20838836 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,16136507 0,20827142 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,16136507 0,20815461 ! cAMP metabolic process GO:0046058 33 18 0,000 0,16136507 0,20803793 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,16136507 0,20792138 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,16136507 0,20780496 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,16136507 0,20768868 ! axis specification GO:0009798 26 18 0,000 0,16136507 0,20757252 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,16136507 0,20745649 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,16136507 0,20734059 ! pancreas development GO:0031016 26 18 0,000 0,16136507 0,20722483 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,16136507 0,20710919 ! glutamine metabolic process GO:0006541 23 18 0,000 0,16136507 0,20699368 ! central nervous system neuron development GO:0021954 30 18 0,000 0,16136507 0,2068783 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,16136507 0,20676304 ! fucose metabolic process GO:0006004 26 18 0,000 0,16136507 0,20664792 ! response to fungus GO:0009620 19 18 0,000 0,16136507 0,20653292 ! peptide cross-linking GO:0018149 31 18 0,000 0,16136507 0,20641806 ! heart process GO:0003015 27 18 0,000 0,16136507 0,20630332 GO:0060047|heart contraction, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,16136507 0,2061887 ! visual learning GO:0008542 35 18 0,000 0,16136507 0,20607422 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,16136507 0,20595986 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,16136507 0,20584563 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,16136507 0,20573152 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,16136507 0,20561754 ! vitamin transport GO:0051180 24 18 0,000 0,16136507 0,20550369 ! hormone transport GO:0009914 27 18 0,000 0,16136507 0,20538996 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,16136507 0,20527636 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,16136507 0,20516289 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,16136507 0,20504954 ! cell-cell recognition GO:0009988 20 18 0,000 0,16136507 0,20493631 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,16136507 0,20482321 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,16136507 0,20471024 ! protein import into nucleus GO:0006606 118 74 1,000 0,16194276 0,20532985 ! blood coagulation GO:0007596 116 75 1,000 0,16537517 0,20956633 GO:0050817|coagulation, ! regulation of ligase activity GO:0051340 114 75 1,000 0,16537517 0,20945093 ! nuclear import GO:0051170 121 75 1,000 0,16537517 0,20933566 ! amine biosynthetic process GO:0009309 97 76 1,000 0,16882039 0,21357915 ! response to unfolded protein GO:0006986 99 76 1,000 0,16882039 0,21346174 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,16882039 0,21334445 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,1695286 0,2141218 ! positive regulation of ossification GO:0045778 30 19 0,000 0,1695286 0,21400428 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,1695286 0,21388688 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,1695286 0,21376962 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,1695286 0,21365249 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,1695286 0,21353548 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,1695286 0,2134186 ! sensory perception of taste GO:0050909 23 19 0,000 0,1695286 0,21330185 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,1695286 0,21318523 ! smooth muscle contraction GO:0006939 36 19 0,000 0,1695286 0,21306874 ! peroxisome organization GO:0007031 29 19 0,000 0,1695286 0,21295237 ! digestive system process GO:0022600 30 19 0,000 0,1695286 0,21283613 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,1695286 0,21272002 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,1695286 0,21260403 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,1695286 0,21248817 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,1695286 0,21237243 ! plasma membrane fusion GO:0045026 23 19 0,000 0,1695286 0,21225683 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,1695286 0,21214134 ! cytolysis GO:0019835 20 19 0,000 0,1695286 0,21202599 ! vasodilation GO:0042311 33 19 0,000 0,1695286 0,21191076 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,1695286 0,21179565 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,1695286 0,21168067 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,1695286 0,21156581 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,1695286 0,21145108 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,1695286 0,21133647 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,1695286 0,21122199 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,1695286 0,21110763 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,1695286 0,21099339 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,1695286 0,21087928 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,1695286 0,21076529 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,1695286 0,21065143 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,1695286 0,21053768 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,1695286 0,21042406 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,1695286 0,21031057 ! protein stabilization GO:0050821 26 19 0,000 0,1695286 0,21019719 ! regulation of DNA binding GO:0051101 119 77 1,000 0,17227785 0,21349087 ! sex differentiation GO:0007548 105 77 1,000 0,17227785 0,2133759 ! protein ubiquitination GO:0016567 125 77 1,000 0,17227785 0,21326106 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,17227785 0,21314634 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,17227785 0,21303175 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,17761313 0,21951113 ! iron ion transport GO:0006826 37 20 0,000 0,17761313 0,21939324 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,17761313 0,21927547 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,17761313 0,21915784 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,17761313 0,21904033 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,17761313 0,21892294 ! spinal cord development GO:0021510 31 20 0,000 0,17761313 0,21880568 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,17761313 0,21868855 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,17761313 0,21857154 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,17761313 0,21845466 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,17761313 0,2183379 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,17761313 0,21822126 ! collagen fibril organization GO:0030199 45 20 0,000 0,17761313 0,21810476 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,17761313 0,21798837 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,17761313 0,21787211 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,17761313 0,21775597 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,17761313 0,21763996 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,17761313 0,21752407 ! alditol metabolic process GO:0019400 24 20 0,000 0,17761313 0,21740831 ! actin filament-based movement GO:0030048 34 20 0,000 0,17761313 0,21729266 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,18271812 0,22341929 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,18271812 0,22330057 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,18561942 0,22672579 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,18561942 0,22660545 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,18561942 0,22648523 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,18561942 0,22636515 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,18561942 0,22624519 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,18561942 0,22612535 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,18561942 0,22600565 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,18561942 0,22588607 ! vesicle docking GO:0048278 27 21 0,000 0,18561942 0,22576661 ! phototransduction GO:0007602 25 21 0,000 0,18561942 0,22564729 ! dendrite development GO:0016358 35 21 0,000 0,18561942 0,22552809 ! visual behavior GO:0007632 39 21 0,000 0,18561942 0,22540901 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,18561942 0,22529006 ! autophagy GO:0006914 28 21 0,000 0,18561942 0,22517124 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,18561942 0,22505254 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,18561942 0,22493396 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,18561942 0,22481552 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,18561942 0,22469719 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,18561942 0,22457899 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,18561942 0,22446092 ! immunoglobulin production GO:0002377 33 21 0,000 0,18561942 0,22434297 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,18561942 0,22422514 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,18561942 0,22410744 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,18561942 0,22398986 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,18561942 0,2238724 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,18561942 0,22375507 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,18561942 0,22363785 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,18561942 0,22352077 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,18561942 0,2234038 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,18561942 0,22328696 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,18561942 0,22317024 ! hemostasis GO:0007599 125 81 1,000 0,18621905 0,22377419 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,18621905 0,22365734 ! regulation of neurological system process GO:0031644 122 81 1,000 0,18621905 0,22354061 ! detection of stimulus GO:0051606 108 82 1,000 0,18972951 0,22763582 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,19354822 0,2320964 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,19354822 0,23197545 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,19354822 0,23185463 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,19354822 0,23173394 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,19354822 0,23161337 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,19354822 0,23149293 ! vasculogenesis GO:0001570 33 22 0,000 0,19354822 0,23137261 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,19354822 0,23125241 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,19354822 0,23113234 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,19354822 0,2310124 ! lysosome organization GO:0007040 37 22 0,000 0,19354822 0,23089258 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,19354822 0,23077288 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,19354822 0,23065331 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,19354822 0,23053387 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,19354822 0,23041454 ! membrane depolarization GO:0051899 35 22 0,000 0,19354822 0,23029534 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,19354822 0,23017626 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,19354822 0,23005731 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,19354822 0,22993848 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,19354822 0,22981977 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,19354822 0,22970118 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,20031305 0,23760702 ! transcription initiation GO:0006352 118 85 1,000 0,20031305 0,23748454 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,20140027 0,2386505 ! neuron fate commitment GO:0048663 32 23 0,000 0,20140027 0,23852761 ! embryonic pattern specification GO:0009880 31 23 0,000 0,20140027 0,23840484 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,20140027 0,23828221 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,20140027 0,2381597 ! vesicle targeting GO:0006903 32 23 0,000 0,20140027 0,23803731 ! osteoblast differentiation GO:0001649 40 23 0,000 0,20140027 0,23791505 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,20140027 0,23779292 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,20140027 0,23767091 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,20140027 0,23754903 ! glycolipid metabolic process GO:0006664 36 23 0,000 0,20140027 0,23742727 ! cell fate determination GO:0001709 45 23 0,000 0,20140027 0,23730564 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,20140027 0,23718413 ! spermatid development GO:0007286 33 23 0,000 0,20140027 0,23706275 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,20140027 0,23694149 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,20140027 0,23682035 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,20140027 0,23669934 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,20140027 0,23657845 ! telomere organization GO:0032200 32 23 0,000 0,20140027 0,23645769 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,20140027 0,23633705 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,20140027 0,23621653 ! regulation of amine transport GO:0051952 38 23 0,000 0,20140027 0,23609613 ! female pregnancy GO:0007565 130 87 1,000 0,20740727 0,24301413 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,20740727 0,24289039 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,20917631 0,24483741 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,20917631 0,24471288 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,20917631 0,24458847 ! superoxide metabolic process GO:0006801 32 24 0,000 0,20917631 0,24446418 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,20917631 0,24434003 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,20917631 0,244216 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,20917631 0,24409209 ! sperm motility GO:0030317 27 24 0,000 0,20917631 0,24396831 ! vacuole organization GO:0007033 39 24 0,000 0,20917631 0,24384466 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,20917631 0,24372113 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,20917631 0,24359773 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,20917631 0,24347445 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,20917631 0,2433513 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,20917631 0,24322827 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,21096452 0,24518362 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 1,000 0,21096452 0,24505979 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,21687708 0,25180075 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,21687708 0,2516737 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,21687708 0,25154679 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,21687708 0,25142 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,21687708 0,25129334 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,21687708 0,25116681 ! peptide transport GO:0015833 43 25 0,000 0,21687708 0,2510404 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,21687708 0,25091413 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,21687708 0,25078797 ! phospholipid transport GO:0015914 35 25 0,000 0,21687708 0,25066195 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,21687708 0,25053605 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,21687708 0,25041028 ! detection of light stimulus GO:0009583 30 25 0,000 0,21687708 0,25028464 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,21687708 0,25015912 GO:0045840|positive regulation of mitosis, ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,21809695 0,2514401 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,2245033 0,25869618 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,2245033 0,25856664 ! translational initiation GO:0006413 43 26 0,000 0,2245033 0,25843723 ! circadian rhythm GO:0007623 42 26 0,000 0,2245033 0,25830795 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,2245033 0,25817879 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,2245033 0,25804977 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,2245033 0,25792087 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,2245033 0,2577921 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,2245033 0,25766347 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,2245033 0,25753495 ! regulation of coagulation GO:0050818 39 26 0,000 0,2245033 0,25740657 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,22525036 0,25813444 ! sulfur metabolic process GO:0006790 118 92 1,000 0,22525036 0,25800589 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,23205568 0,26566853 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,23205568 0,26553635 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,23205568 0,26540431 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,23205568 0,2652724 ! membrane docking GO:0022406 39 27 0,000 0,23205568 0,26514062 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,23205568 0,26500897 ! catechol metabolic process GO:0009712 43 27 0,000 0,23205568 0,26487745 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,23205568 0,26474607 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,23205568 0,26461481 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,23205568 0,26448368 ! natural killer cell activation GO:0030101 35 27 0,000 0,23205568 0,26435268 ! cofactor catabolic process GO:0051187 45 27 0,000 0,23205568 0,26422182 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,23205568 0,26409108 GO:0043433|negative regulation of transcription factor activity, ! gene silencing GO:0016458 41 27 0,000 0,23205568 0,26396047 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,23953495 0,27233335 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,23953495 0,2721988 ! phenol metabolic process GO:0018958 44 28 0,000 0,23953495 0,27206438 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,23953495 0,2719301 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,23953495 0,27179594 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,23953495 0,27166192 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,23953495 0,27152803 GO:0055092|sterol homeostasis, ! complement activation, classical pathway GO:0006958 36 28 0,000 0,23953495 0,27139427 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,23953495 0,27126065 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,23953495 0,27112715 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,23953495 0,27099379 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,23953495 0,27086056 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,23953495 0,27072746 ! mesoderm formation GO:0001707 46 28 0,000 0,23953495 0,27059449 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,23953495 0,27046165 ! BMP signaling pathway GO:0030509 40 28 0,000 0,23953495 0,27032894 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,23953495 0,27019636 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,23953495 0,27006391 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,23960634 0,27001204 ! protein maturation GO:0051604 129 96 1,000 0,23960634 0,26987981 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,24320318 0,27379702 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,24320318 0,27366307 ! regulation of innate immune response GO:0045088 38 29 0,000 0,24694179 0,27773404 ! protein targeting to membrane GO:0006612 53 29 0,000 0,24694179 0,2775983 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,24694179 0,27746269 ! mismatch repair GO:0006298 34 29 0,000 0,24694179 0,27732721 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,24694179 0,27719186 ! formation of primary germ layer GO:0001704 48 29 0,000 0,24694179 0,27705664 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,24694179 0,27692156 ! eye morphogenesis GO:0048592 51 29 0,000 0,24694179 0,27678661 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,24694179 0,27665179 ! protein import GO:0017038 156 99 1,000 0,25040352 0,28039343 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,25400626 0,28428925 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,25400626 0,28415098 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,25400626 0,28401284 ! protein localization in organelle GO:0033365 161 100 1,000 0,25400626 0,28387483 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,25427691 0,28403929 ! organic anion transport GO:0015711 51 30 0,000 0,25427691 0,28390141 ! cholesterol transport GO:0030301 46 30 0,000 0,25427691 0,28376366 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,25427691 0,28362604 ! spindle organization GO:0007051 37 30 0,000 0,25427691 0,28348856 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,25427691 0,28335121 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,25427691 0,28321399 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,25427691 0,28307691 ! ceramide metabolic process GO:0006672 43 30 0,000 0,25427691 0,28293996 ! adult locomotory behavior GO:0008344 47 30 0,000 0,25427691 0,28280314 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,25427691 0,28266646 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,25427691 0,2825299 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,25427691 0,28239348 ! negative regulation of secretion GO:0051048 49 31 0,000 0,261541 0,29032061 ! glial cell differentiation GO:0010001 55 31 0,000 0,261541 0,29018056 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,261541 0,29004065 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,261541 0,28990087 ! odontogenesis GO:0042476 50 31 0,000 0,261541 0,28976123 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,261541 0,28962172 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,261541 0,28948234 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,261541 0,2893431 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,261541 0,289204 ! RNA modification GO:0009451 40 31 0,000 0,261541 0,28906502 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,26873475 0,29687316 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,26873475 0,29673064 ! meiosis I GO:0007127 52 32 0,000 0,26873475 0,29658825 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,26873475 0,29644601 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,26873475 0,29630389 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 44 32 0,000 0,26873475 0,29616192 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,26873475 0,29602008 ! vesicle localization GO:0051648 47 32 0,000 0,26873475 0,29587837 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,27585882 0,30357669 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,27585882 0,30343151 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,27585882 0,30328647 ! sister chromatid segregation GO:0000819 46 33 0,000 0,27585882 0,30314156 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,27585882 0,3029968 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,27585882 0,30285217 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,27585882 0,30270768 ! regulation of proteolysis GO:0030162 50 33 0,000 0,27585882 0,30256332 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,27585882 0,30241911 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,27585882 0,30227503 ! cytokinesis GO:0000910 52 33 0,000 0,27585882 0,30213109 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,27585882 0,30198729 ! mRNA catabolic process GO:0006402 48 34 0,000 0,2829139 0,30956326 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,2829139 0,30941606 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,2829139 0,30926899 ! feeding behavior GO:0007631 45 34 0,000 0,2829139 0,30912207 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,2829139 0,30897529 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,2829139 0,30882865 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,2829139 0,30868215 ! aerobic respiration GO:0009060 47 34 0,000 0,2829139 0,30853578 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,2829139 0,30838956 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,2829139 0,30824347 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,28990064 0,31570619 ! Notch signaling pathway GO:0007219 56 35 0,000 0,28990064 0,31555677 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,28990064 0,3154075 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,28990064 0,31525838 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,28990064 0,31510939 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,28990064 0,31496054 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,28990064 0,31481183 ! protein homooligomerization GO:0051260 52 35 0,000 0,28990064 0,31466327 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,2968197 0,32202137 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,2968197 0,32186955 ! negative regulation of binding GO:0051100 58 36 0,000 0,2968197 0,32171787 ! organic ether metabolic process GO:0018904 46 36 0,000 0,2968197 0,32156633 ! tissue remodeling GO:0048771 62 36 0,000 0,2968197 0,32141493 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,2968197 0,32126368 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,2968197 0,32111256 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,2968197 0,32096159 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,30367174 0,32821663 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,30367174 0,32806247 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,30367174 0,32790845 ! ion transmembrane transport GO:0034220 56 37 0,000 0,30367174 0,32775457 ! regulation of protein secretion GO:0050708 51 37 0,000 0,30367174 0,32760084 ! amino acid activation GO:0043038 52 37 0,000 0,30367174 0,32744726 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,30367174 0,32729381 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,3104574 0,33445059 ! gliogenesis GO:0042063 71 38 0,000 0,3104574 0,33429401 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,3104574 0,33413758 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,31717731 0,34121039 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,31717731 0,34105087 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,31717731 0,34089151 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,31717731 0,34073228 ! JNK cascade GO:0007254 54 39 0,000 0,31717731 0,34057321 ! cell growth GO:0016049 61 39 0,000 0,31717731 0,34041429 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,32383212 0,34739454 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,32383212 0,34723258 ! regulation of tube size GO:0035150 60 40 0,000 0,32383212 0,34707078 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,32383212 0,34690912 ! inner ear development GO:0048839 57 40 0,000 0,32383212 0,34674762 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,32383212 0,34658627 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,32383212 0,34642506 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,32383212 0,34626401 ! endosome transport GO:0016197 71 41 0,000 0,33042245 0,35314667 ! striated muscle contraction GO:0006941 62 41 0,000 0,33042245 0,35298265 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,33042245 0,35281878 ! biopolymer methylation GO:0043414 62 41 0,000 0,33042245 0,35265506 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,33042245 0,35249149 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,33694893 0,35928722 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,33694893 0,35912073 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,33694893 0,35895439 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,33694893 0,35878821 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,33694893 0,35862218 ! excretion GO:0007588 63 42 0,000 0,33694893 0,3584563 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,33694893 0,35829058 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,33694893 0,35812501 ! neuromuscular process GO:0050905 79 43 0,000 0,34341215 0,36482584 ! tRNA processing GO:0008033 49 43 0,000 0,34341215 0,36465741 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,34341215 0,36448913 ! methylation GO:0032259 64 43 0,000 0,34341215 0,36432101 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,34981274 0,37094021 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,34981274 0,37076927 ! glycolysis GO:0006096 53 44 0,000 0,34981274 0,37059849 ! regulation of ion transport GO:0043269 57 44 0,000 0,34981274 0,37042786 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,34981274 0,37025739 ! RNA catabolic process GO:0006401 64 45 0,000 0,35615131 0,37679301 ! regulation of translational initiation GO:0006446 64 45 0,000 0,35615131 0,37661977 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,35615131 0,37644669 ! cell recognition GO:0008037 58 45 0,000 0,35615131 0,37627377 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,36242843 0,38272975 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,36242843 0,38255411 ! cell redox homeostasis GO:0045454 63 46 0,000 0,36242843 0,38237862 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,36242843 0,3822033 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,36864472 0,38858059 ! endocrine system development GO:0035270 83 47 0,000 0,36864472 0,38840259 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,36864472 0,38822475 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,36864472 0,38804707 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,36864472 0,38786956 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,36864472 0,38769221 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,37480075 0,39398616 ! gastrulation GO:0007369 73 48 0,000 0,37480075 0,39380618 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,37480075 0,39362636 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,37480075 0,3934467 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,37480075 0,39326721 ! nuclear export GO:0051168 69 48 0,000 0,37480075 0,39308788 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,37480075 0,39290872 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,38089711 0,3991177 ! sensory perception of smell GO:0007608 61 49 0,000 0,38089711 0,39893595 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,38089711 0,39875437 ! RNA elongation GO:0006354 62 49 0,000 0,38089711 0,39857295 ! regulation of actin filament length GO:0030832 72 50 0,000 0,38693436 0,40470625 ! membrane fusion GO:0006944 80 50 0,000 0,38693436 0,40452229 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,38693436 0,4043385 ! proton transport GO:0015992 75 50 0,000 0,38693436 0,40415488 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,38693436 0,40397142 ! positive regulation of secretion GO:0051047 71 51 0,000 0,39291309 0,41002727 ! hydrogen transport GO:0006818 77 51 0,000 0,39291309 0,40984132 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,39291309 0,40965553 ! adult behavior GO:0030534 80 51 0,000 0,39291309 0,40946992 ! transition metal ion transport GO:0000041 74 52 0,000 0,39883385 0,41545193 ! regulation of cellular component size GO:0032535 74 52 0,000 0,39883385 0,41526386 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,39883385 0,41507595 ! establishment of organelle localization GO:0051656 85 52 0,000 0,39883385 0,41488822 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,4046972 0,42079727 ! single fertilization GO:0007338 59 53 0,000 0,4046972 0,42060713 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,4105037 0,42644919 ! glucose catabolic process GO:0006007 66 54 0,000 0,4105037 0,42625667 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,4105037 0,42606431 ! exocytosis GO:0006887 74 55 0,000 0,4162539 0,4318376 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,4162539 0,4316429 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,42194833 0,43735068 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,42758753 0,44299609 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,42758753 0,44279663 ! camera-type eye development GO:0043010 88 57 0,000 0,42758753 0,44259735 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,43317204 0,4481762 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,43317204 0,44797469 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,44417909 0,45915142 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,44417909 0,45894515 ! fertilization GO:0009566 68 60 0,000 0,44417909 0,45873907 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,44960267 0,46413202 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,44960267 0,4639238 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,44960267 0,46371576 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,45497363 0,46904498 ! neurotransmitter transport GO:0006836 81 62 0,000 0,45497363 0,46883484 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,45497363 0,46862488 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,45497363 0,46841511 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,46029249 0,47367907 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,46029249 0,47346723 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,46555974 0,47867117 ! hexose catabolic process GO:0019320 82 64 0,000 0,46555974 0,47845729 ! adaptive immune response GO:0002250 94 64 0,000 0,46555974 0,47824359 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! defense response to bacterium GO:0042742 73 65 0,000 0,47077589 0,48338596 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,47077589 0,48317026 ! activation of immune response GO:0002253 83 65 0,000 0,47077589 0,48295475 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,47594142 0,48803623 ! antigen processing and presentation GO:0019882 96 66 0,000 0,47594142 0,48781875 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,47594142 0,48760146 ! regulation of immune effector process GO:0002697 101 66 0,000 0,47594142 0,48738436 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,4861226 0,49758877 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,4861226 0,49736743 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,4911392 0,50227664 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,4911392 0,50205341 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,49610712 0,50690643 ! eye development GO:0001654 111 70 0,000 0,49610712 0,50668134 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,49610712 0,50645645 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,50102682 0,51125186 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,50102682 0,51102514 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,50102682 0,51079862 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,50589876 0,51553707 ! digestion GO:0007586 97 74 0,000 0,51550123 0,52508983 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,52023267 0,52967469 ! tRNA metabolic process GO:0006399 95 76 0,000 0,52491816 0,53420875 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,52955817 0,53869252 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,52955817 0,53845437 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,52955817 0,53821643 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,53415312 0,54264672 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,53870345 0,54702779 ! cellular respiration GO:0045333 107 79 0,000 0,53870345 0,54678638 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,53870345 0,54654519 ! regulation of lyase activity GO:0051339 133 79 0,000 0,53870345 0,5463042 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,53870345 0,54606344 ! chromatin assembly GO:0031497 102 80 0,000 0,54320959 0,55038858 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,54320959 0,55014622 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,54320959 0,54990408 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,54767198 0,55417754 ! mRNA transport GO:0051028 121 81 0,000 0,54767198 0,55393384 ! vitamin metabolic process GO:0006766 103 81 0,000 0,54767198 0,55369035 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,55646714 0,56233498 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,55646714 0,56208802 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,56080076 0,56621674 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,56080076 0,56596829 ! sterol metabolic process GO:0016125 120 84 0,000 0,56080076 0,56572006 ! rRNA metabolic process GO:0016072 107 85 0,000 0,56509228 0,56979931 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,56934211 0,57383298 ! nucleosome organization GO:0034728 114 87 0,000 0,57355065 0,57782151 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,57355065 0,57756852 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,57771831 0,58151077 ! establishment of RNA localization GO:0051236 128 88 0,000 0,57771831 0,58125639 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,58184547 0,58515286 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,58184547 0,58489711 ! hormone metabolic process GO:0042445 121 90 0,000 0,58593254 0,58874829 ! RNA localization GO:0006403 135 91 0,000 0,58997988 0,59255621 ! ATP metabolic process GO:0046034 137 91 0,000 0,58997988 0,59229757 ! positive regulation of immune response GO:0050778 121 92 0,000 0,5939879 0,59606116 ! DNA recombination GO:0006310 146 92 0,000 0,5939879 0,59580121 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,59795697 0,59952093 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,59795697 0,5992597 ! electron transport chain GO:0022900 123 94 0,000 0,60188746 0,60293604 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,6096342 0,61043042 ! calcium ion transport GO:0006816 167 99 0,000 0,62097422 0,62151466 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,62468096 0,62495268 ! divalent metal ion transport GO:0070838 171 100 0,000 0,62468096 0,62468096