pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6619-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 115 46 7,000 1,877E-09 4,517E-06 ! cellular response to insulin stimulus GO:0032869 82 37 6,000 1,07E-08 1,287E-05 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 7,000 1,107E-08 8,879E-06 ! phospholipid dephosphorylation GO:0046839 12 5 3,000 1,562E-08 9,398E-06 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 3,000 1,562E-08 7,518E-06 ! response to peptide hormone stimulus GO:0043434 122 61 7,000 1,923E-08 7,71E-06 ! insulin receptor signaling pathway GO:0008286 64 26 5,000 3,483E-08 1,197E-05 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 4,659E-08 1,401E-05 ! response to insulin stimulus GO:0032868 95 46 6,000 5,252E-08 1,404E-05 ! cell-matrix adhesion GO:0007160 163 75 7,000 1,006E-07 2,421E-05 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 3,000 1,081E-07 2,364E-05 ! negative regulation of focal adhesion formation GO:0051895 20 7 3,000 1,081E-07 2,167E-05 ! cell-substrate adhesion GO:0031589 171 81 7,000 1,845E-07 3,415E-05 ! regulation of focal adhesion formation GO:0051893 22 8 3,000 2,149E-07 3,693E-05 ! integrin-mediated signaling pathway GO:0007229 135 59 6,000 3,08E-07 4,941E-05 ! negative regulation of striated muscle development GO:0045843 19 10 3,000 6,37E-07 9,579E-05 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 3,000 6,37E-07 9,016E-05 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 3,000 6,37E-07 8,515E-05 ! interphase of mitotic cell cycle GO:0051329 209 95 7,000 6,371E-07 8,068E-05 ! regulation of cell-matrix adhesion GO:0001952 78 23 4,000 7,012E-07 8,435E-05 GO:0010810|regulation of cell-substrate adhesion, ! interphase GO:0051325 213 98 7,000 8,09E-07 9,269E-05 ! negative regulation of muscle development GO:0048635 20 11 3,000 9,951E-07 1,088E-04 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 3,000 9,951E-07 1,041E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! induction of apoptosis by intracellular signals GO:0008629 93 45 5,000 1,093E-06 1,096E-04 ! negative regulation of cell migration GO:0030336 115 46 5,000 1,25E-06 1,203E-04 ! response to UV GO:0009411 104 53 5,000 2,931E-06 2,712E-04 ! cellular response to hormone stimulus GO:0032870 167 82 6,000 2,964E-06 2,641E-04 ! release of cytochrome c from mitochondria GO:0001836 30 14 3,000 2,965E-06 2,548E-04 ! negative regulation of cell motion GO:0051271 134 55 5,000 3,655E-06 3,032E-04 ! cell adhesion mediated by integrin GO:0033627 8 5 2,000 4,179E-06 3,352E-04 ! negative regulation of survival gene product expression GO:0008634 8 5 2,000 4,179E-06 3,243E-04 ! L-serine biosynthetic process GO:0006564 6 5 2,000 4,179E-06 3,142E-04 ! lipid modification GO:0030258 97 57 5,000 4,518E-06 3,294E-04 ! regulation of cell adhesion GO:0030155 212 89 6,000 5,138E-06 3,636E-04 ! regulation of striated muscle tissue development GO:0016202 69 34 4,000 5,419E-06 3,725E-04 ! regulation of muscle development GO:0048634 70 35 4,000 6,284E-06 4,2E-04 ! endothelial cell migration GO:0043542 28 17 3,000 6,926E-06 4,504E-04 ! inositol metabolic process GO:0006020 28 17 3,000 6,926E-06 4,385E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 3,000 6,926E-06 4,273E-04 ! cardiac muscle tissue development GO:0048738 31 17 3,000 6,926E-06 4,166E-04 ! nucleoside catabolic process GO:0009164 7 6 2,000 8,311E-06 4,877E-04 ! regulation of protein stability GO:0031647 73 37 4,000 8,335E-06 4,775E-04 ! cell-substrate junction assembly GO:0007044 54 18 3,000 8,852E-06 4,953E-04 ! negative regulation of translation GO:0017148 29 20 3,000 1,385E-05 7,574E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 1,385E-05 7,406E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 1,446E-05 7,565E-04 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 2,000 1,446E-05 7,404E-04 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! purine salvage GO:0043101 10 7 2,000 1,446E-05 7,25E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 1,446E-05 7,102E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 1,446E-05 6,96E-04 ! inactivation of MAPK activity GO:0000188 39 21 3,000 1,701E-05 8,024E-04 ! positive regulation of inflammatory response GO:0050729 35 21 3,000 1,701E-05 7,87E-04 ! gut development GO:0048565 39 21 3,000 1,701E-05 7,721E-04 ! phosphoinositide metabolic process GO:0030384 128 72 5,000 1,77E-05 7,889E-04 ! apoptotic nuclear changes GO:0030262 32 22 3,000 2,067E-05 9,04E-04 ! ER overload response GO:0006983 12 8 2,000 2,301E-05 9,887E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 2,000 2,301E-05 9,714E-04 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 2,301E-05 9,546E-04 ! purine ribonucleoside metabolic process GO:0046128 34 23 3,000 2,487E-05 1,014E-03 GO:0042278|purine nucleoside metabolic process, ! negative regulation of phosphorylation GO:0042326 47 24 3,000 2,967E-05 1,19E-03 ! regulation of inflammatory response GO:0050727 75 48 4,000 3,061E-05 1,207E-03 ! induction of positive chemotaxis GO:0050930 15 9 2,000 3,433E-05 1,332E-03 ! response to endoplasmic reticulum stress GO:0034976 43 25 3,000 3,511E-05 1,341E-03 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 3,000 4,125E-05 1,551E-03 GO:0045936|negative regulation of phosphate metabolic process, ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 3,000 4,814E-05 1,782E-03 ! mitochondrial membrane organization GO:0007006 57 27 3,000 4,814E-05 1,755E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 4,877E-05 1,751E-03 ! L-serine metabolic process GO:0006563 18 10 2,000 4,877E-05 1,725E-03 ! DNA ligation GO:0006266 19 10 2,000 4,877E-05 1,7E-03 ! cellular metabolic compound salvage GO:0043094 14 10 2,000 4,877E-05 1,676E-03 ! ER-nuclear signaling pathway GO:0006984 48 28 3,000 5,583E-05 1,892E-03 ! cellular response to extracellular stimulus GO:0031668 48 29 3,000 6,438E-05 2,151E-03 ! negative regulation of glucose import GO:0046325 17 11 2,000 6,668E-05 2,198E-03 GO:0010829|negative regulation of glucose transport, ! chondrocyte differentiation GO:0002062 24 11 2,000 6,668E-05 2,168E-03 ! negative regulation of ossification GO:0030279 26 11 2,000 6,668E-05 2,139E-03 ! cell junction assembly GO:0034329 78 30 3,000 7,385E-05 2,338E-03 ! negative regulation of protein kinase cascade GO:0010741 68 30 3,000 7,385E-05 2,307E-03 ! regulation of positive chemotaxis GO:0050926 19 12 2,000 8,841E-05 2,727E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 35 12 2,000 8,841E-05 2,693E-03 ! negative regulation of MAP kinase activity GO:0043407 69 32 3,000 9,576E-05 2,88E-03 ! serine family amino acid biosynthetic process GO:0009070 17 13 2,000 1,143E-04 3,395E-03 ! negative regulation of cell adhesion GO:0007162 81 35 3,000 1,37E-04 4,019E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 2,000 1,447E-04 4,193E-03 ! response to gamma radiation GO:0010332 28 14 2,000 1,447E-04 4,143E-03 ! cell junction organization GO:0034330 86 36 3,000 1,532E-04 4,337E-03 ! negative regulation of protein kinase activity GO:0006469 130 67 4,000 1,537E-04 4,3E-03 ! negative regulation of kinase activity GO:0033673 131 68 4,000 1,649E-04 4,56E-03 ! negative regulation of bone remodeling GO:0046851 33 15 2,000 1,798E-04 4,916E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 1,798E-04 4,861E-03 ! nucleus organization GO:0006997 67 38 3,000 1,897E-04 5,072E-03 ! negative regulation of transferase activity GO:0051348 140 72 4,000 2,16E-04 5,71E-03 ! negative regulation of tissue remodeling GO:0034104 36 16 2,000 2,201E-04 5,756E-03 ! defense response to virus GO:0051607 37 16 2,000 2,201E-04 5,694E-03 ! ribonucleoside metabolic process GO:0009119 55 40 3,000 2,322E-04 5,942E-03 ! regulation of T cell differentiation GO:0045580 70 41 3,000 2,557E-04 6,477E-03 ! polyol metabolic process GO:0019751 66 41 3,000 2,557E-04 6,409E-03 ! phosphoinositide-mediated signaling GO:0048015 131 75 4,000 2,616E-04 6,489E-03 ! regulation of viral genome replication GO:0045069 28 17 2,000 2,658E-04 6,525E-03 ! regulation of survival gene product expression GO:0045884 33 17 2,000 2,658E-04 6,459E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 2,000 2,658E-04 6,394E-03 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 2,000 2,658E-04 6,331E-03 ! neutrophil chemotaxis GO:0030593 27 17 2,000 2,658E-04 6,269E-03 ! positive regulation of response to external stimulus GO:0032103 77 43 3,000 3,08E-04 7,195E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 3,171E-04 7,337E-03 ! positive regulation of phosphorylation GO:0042327 129 79 4,000 3,334E-04 7,639E-03 ! B cell differentiation GO:0030183 107 44 3,000 3,368E-04 7,645E-03 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 4,000 3,744E-04 8,419E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 171 81 4,000 3,744E-04 8,341E-03 ! neuromuscular junction development GO:0007528 34 19 2,000 3,745E-04 8,267E-03 ! proximal/distal pattern formation GO:0009954 32 19 2,000 3,745E-04 8,192E-03 ! pigmentation GO:0043473 100 46 3,000 4,001E-04 8,673E-03 ! response to oxygen levels GO:0070482 176 83 4,000 4,191E-04 9,004E-03 ! positive regulation of defense response GO:0031349 76 47 3,000 4,348E-04 9,258E-03 ! response to alkaloid GO:0043279 38 20 2,000 4,382E-04 9,248E-03 ! cellular response to starvation GO:0009267 33 20 2,000 4,382E-04 9,167E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 2,000 4,382E-04 9,088E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 4,382E-04 9,011E-03 ! regulation of glucose import GO:0046324 29 20 2,000 4,382E-04 8,934E-03 GO:0010827|regulation of glucose transport, ! mitochondrial transport GO:0006839 82 48 3,000 4,715E-04 9,534E-03 ! regulation of lymphocyte differentiation GO:0045619 81 48 3,000 4,715E-04 9,454E-03 ! regulation of mast cell proliferation GO:0070666 81 48 3,000 4,715E-04 9,376E-03 ! mitochondrion organization GO:0007005 148 86 4,000 4,936E-04 9,735E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 5,084E-04 9,944E-03 ! cell aging GO:0007569 44 21 2,000 5,084E-04 9,864E-03 ! positive regulation of locomotion GO:0040017 39 21 2,000 5,084E-04 9,785E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 1,000 5,572E-04 0,01064017 ! apoptotic cell clearance GO:0043277 20 5 1,000 5,572E-04 0,01055639 ! positive regulation of glycolysis GO:0045821 14 5 1,000 5,572E-04 0,01047392 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 1,000 5,572E-04 0,01039272 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 5,572E-04 0,01031278 ! epithelial cell proliferation GO:0050673 9 5 1,000 5,572E-04 0,01023406 ! regulation of retroviral genome replication GO:0045091 7 5 1,000 5,572E-04 0,01015653 ! microvillus organization GO:0032528 7 5 1,000 5,572E-04 0,01008016 GO:0030033|microvillus assembly, ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 5,572E-04 0,01000494 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 5,572E-04 9,931E-03 ! peptidyl-histidine phosphorylation GO:0018106 9 5 1,000 5,572E-04 9,858E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 5,572E-04 9,786E-03 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 1,000 5,572E-04 9,715E-03 ! enteric nervous system development GO:0048484 8 5 1,000 5,572E-04 9,645E-03 ! B cell homeostasis GO:0001782 13 5 1,000 5,572E-04 9,576E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 5,572E-04 9,508E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 5,572E-04 9,441E-03 ! receptor biosynthetic process GO:0032800 7 5 1,000 5,572E-04 9,375E-03 ! phospholipid scrambling GO:0017121 8 5 1,000 5,572E-04 9,31E-03 ! regulation of chemotaxis GO:0050920 40 22 2,000 5,854E-04 9,713E-03 ! keratinization GO:0031424 28 22 2,000 5,854E-04 9,647E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 5,854E-04 9,581E-03 ! ureteric bud development GO:0001657 43 22 2,000 5,854E-04 9,516E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 3,000 5,95E-04 9,608E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! epithelial tube morphogenesis GO:0060562 98 51 3,000 5,95E-04 9,544E-03 ! leukocyte adhesion GO:0007159 50 23 2,000 6,694E-04 0,01066675 ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 6,694E-04 0,01059657 ! regulation of viral reproduction GO:0050792 38 23 2,000 6,694E-04 0,01052731 ! regulation of defense response GO:0031347 149 92 4,000 6,721E-04 0,01050036 ! positive regulation of MAP kinase activity GO:0043406 160 93 4,000 7,06E-04 0,01095858 ! regulation of membrane potential GO:0042391 164 93 4,000 7,06E-04 0,01088833 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 2,000 7,608E-04 0,01165974 ! regulation of behavior GO:0050795 43 24 2,000 7,608E-04 0,01158594 ! protein tetramerization GO:0051262 52 24 2,000 7,608E-04 0,01151307 ! leukocyte differentiation GO:0002521 202 96 4,000 8,153E-04 0,01226026 ! male meiosis GO:0007140 7 6 1,000 8,317E-04 0,01242853 ! toxin metabolic process GO:0009404 11 6 1,000 8,317E-04 0,01235181 ! male sex determination GO:0030238 15 6 1,000 8,317E-04 0,01227603 ! deoxyribonucleoside metabolic process GO:0009120 8 6 1,000 8,317E-04 0,01220118 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 8,317E-04 0,01212723 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 12 6 1,000 8,317E-04 0,01205418 ! neuron apoptosis GO:0051402 9 6 1,000 8,317E-04 0,011982 ! nucleoside salvage GO:0043174 9 6 1,000 8,317E-04 0,01191068 GO:0006166|purine ribonucleoside salvage, ! neural nucleus development GO:0048857 14 6 1,000 8,317E-04 0,0118402 ! interaction with symbiont GO:0051702 13 6 1,000 8,317E-04 0,01177055 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 1,000 8,317E-04 0,01170172 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 8,317E-04 0,01163368 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 8,317E-04 0,01156644 ! regulation of DNA replication GO:0006275 101 56 3,000 8,492E-04 0,01174217 ! regulation of DNA metabolic process GO:0051052 178 97 4,000 8,544E-04 0,01174703 ! myelination GO:0042552 45 25 2,000 8,598E-04 0,01175389 ! response to starvation GO:0042594 42 25 2,000 8,598E-04 0,01168748 ! negative regulation of cell development GO:0010721 73 25 2,000 8,598E-04 0,01162182 GO:0050768|negative regulation of neurogenesis, ! interaction with host GO:0051701 62 25 2,000 8,598E-04 0,01155689 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 2,000 8,598E-04 0,01149269 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! cellular response to nutrient levels GO:0031669 41 25 2,000 8,598E-04 0,01142919 ! response to virus GO:0009615 160 98 4,000 8,949E-04 0,01183044 ! positive regulation of cell migration GO:0030335 126 57 3,000 9,079E-04 0,01193702 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 2,000 9,666E-04 0,01263895 ! cell cycle arrest GO:0007050 213 100 4,000 9,801E-04 0,0127471 ! cytokine-mediated signaling pathway GO:0019221 97 59 3,000 1,034E-03 0,01337396 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 1,081E-03 0,0139133 ! fat cell differentiation GO:0045444 50 27 2,000 1,081E-03 0,01383929 ! response to toxin GO:0009636 47 27 2,000 1,081E-03 0,01376607 ! base-excision repair GO:0006284 41 27 2,000 1,081E-03 0,01369361 ! nucleoside metabolic process GO:0009116 81 60 3,000 1,101E-03 0,01387251 ! protein amino acid autophosphorylation GO:0046777 141 60 3,000 1,101E-03 0,01380026 ! negative regulation of response to stimulus GO:0048585 100 60 3,000 1,101E-03 0,01372875 ! regulation of helicase activity GO:0051095 15 7 1,000 1,159E-03 0,01436841 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 1,159E-03 0,01429472 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 1,159E-03 0,01422179 ! lipoprotein transport GO:0042953 14 7 1,000 1,159E-03 0,0141496 ! organ growth GO:0035265 15 7 1,000 1,159E-03 0,01407814 ! wound healing, spreading of epidermal cells GO:0035313 14 7 1,000 1,159E-03 0,01400739 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 1,159E-03 0,01393736 ! response to tumor cell GO:0002347 13 7 1,000 1,159E-03 0,01386802 ! regulation of respiratory burst GO:0060263 11 7 1,000 1,159E-03 0,01379936 ! peptidyl-histidine modification GO:0018202 16 7 1,000 1,159E-03 0,01373138 ! peptidyl-threonine modification GO:0018210 25 7 1,000 1,159E-03 0,01366407 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 1,159E-03 0,01359742 ! negative regulation of protein modification process GO:0031400 60 28 2,000 1,204E-03 0,01406739 ! positive regulation of T cell differentiation GO:0045582 42 28 2,000 1,204E-03 0,01399943 ! peptidyl-tyrosine modification GO:0018212 50 28 2,000 1,204E-03 0,01393212 ! viral reproductive process GO:0022415 126 62 3,000 1,245E-03 0,01433399 ! tissue homeostasis GO:0001894 48 29 2,000 1,336E-03 0,01530657 GO:0048871|multicellular organismal homeostasis, ! positive regulation of cell motion GO:0051272 146 64 3,000 1,402E-03 0,01598295 ! ensheathment of neurons GO:0007272 57 30 2,000 1,476E-03 0,01675374 GO:0008366|axon ensheathment, ! embryonic limb morphogenesis GO:0030326 125 65 3,000 1,485E-03 0,01677254 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 1,000 1,537E-03 0,01728118 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 1,537E-03 0,0172008 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,537E-03 0,01712117 ! reflex GO:0060004 16 8 1,000 1,537E-03 0,01704227 ! pigment granule organization GO:0048753 16 8 1,000 1,537E-03 0,01696409 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,537E-03 0,01688663 ! regulation of pigmentation during development GO:0048070 24 8 1,000 1,537E-03 0,01680987 ! melanin metabolic process GO:0006582 15 8 1,000 1,537E-03 0,01673381 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 1,537E-03 0,01665843 ! response to UV-B GO:0010224 16 8 1,000 1,537E-03 0,01658373 ! DNA topological change GO:0006265 12 8 1,000 1,537E-03 0,01650969 ! regulation of fat cell differentiation GO:0045598 15 8 1,000 1,537E-03 0,01643632 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 1,000 1,537E-03 0,01636359 ! trophectodermal cell differentiation GO:0001829 13 8 1,000 1,537E-03 0,01629151 ! serine family amino acid metabolic process GO:0009069 49 31 2,000 1,625E-03 0,01715181 ! negative regulation of cell growth GO:0030308 132 67 3,000 1,661E-03 0,01745589 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 3,000 1,661E-03 0,01737999 ! viral reproduction GO:0016032 134 68 3,000 1,755E-03 0,01827896 ! metanephros development GO:0001656 74 32 2,000 1,784E-03 0,01849709 ! response to ionizing radiation GO:0010212 65 32 2,000 1,784E-03 0,0184177 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 2,000 1,784E-03 0,018339 ! positive regulation of catabolic process GO:0009896 64 32 2,000 1,784E-03 0,01826096 ! cell cycle checkpoint GO:0000075 137 69 3,000 1,852E-03 0,01888188 ! negative regulation of cell size GO:0045792 134 69 3,000 1,852E-03 0,01880221 ! DNA damage checkpoint GO:0000077 71 33 2,000 1,951E-03 0,01972434 ! leukocyte chemotaxis GO:0030595 50 33 2,000 1,951E-03 0,01964182 GO:0060326|cell chemotaxis, ! appendage morphogenesis GO:0035107 135 70 3,000 1,953E-03 0,01957756 GO:0035108|limb morphogenesis, ! regulation of developmental growth GO:0048638 15 9 1,000 1,966E-03 0,01963151 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,966E-03 0,01955039 ! regulation of glycolysis GO:0006110 21 9 1,000 1,966E-03 0,01946994 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,966E-03 0,01939014 ! T cell selection GO:0045058 23 9 1,000 1,966E-03 0,019311 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 1,000 1,966E-03 0,0192325 ! behavioral fear response GO:0001662 22 9 1,000 1,966E-03 0,01915463 GO:0002209|behavioral defense response, ! motor axon guidance GO:0008045 16 9 1,000 1,966E-03 0,0190774 ! protein heterooligomerization GO:0051291 16 9 1,000 1,966E-03 0,01900078 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 1,966E-03 0,01892478 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 1,966E-03 0,01884938 ! regulation of telomere maintenance GO:0032204 14 9 1,000 1,966E-03 0,01877458 ! mitochondrion localization GO:0051646 15 9 1,000 1,966E-03 0,01870037 ! appendage development GO:0048736 136 71 3,000 2,057E-03 0,01948851 GO:0060173|limb development, ! B cell activation GO:0042113 160 71 3,000 2,057E-03 0,01941209 ! placenta development GO:0001890 53 34 2,000 2,128E-03 0,02000106 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 2,000 2,128E-03 0,01992324 ! regulation of caspase activity GO:0043281 122 72 3,000 2,166E-03 0,02019649 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 3,000 2,166E-03 0,02011852 ! regulation of endopeptidase activity GO:0052548 125 74 3,000 2,394E-03 0,02215395 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 2,446E-03 0,02254659 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 1,000 2,446E-03 0,02246054 ! B cell proliferation GO:0042100 18 10 1,000 2,446E-03 0,02237514 ! alpha-beta T cell activation GO:0046631 23 10 1,000 2,446E-03 0,02229038 ! positive regulation of viral reproduction GO:0048524 18 10 1,000 2,446E-03 0,02220627 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 2,446E-03 0,02212278 GO:0043470|regulation of carbohydrate catabolic process, ! oocyte development GO:0048599 17 10 1,000 2,446E-03 0,02203993 ! blastocyst formation GO:0001825 17 10 1,000 2,446E-03 0,02195769 ! response to nicotine GO:0035094 20 10 1,000 2,446E-03 0,02187606 ! localization within membrane GO:0051668 20 10 1,000 2,446E-03 0,02179504 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 1,000 2,446E-03 0,02171461 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 2,446E-03 0,02163478 ! glucan biosynthetic process GO:0009250 14 10 1,000 2,446E-03 0,02155553 GO:0005978|glycogen biosynthetic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 2,446E-03 0,02147686 ! regulation of gliogenesis GO:0014013 23 10 1,000 2,446E-03 0,02139877 GO:0045685|regulation of glial cell differentiation, ! positive regulation of phagocytosis GO:0050766 13 10 1,000 2,446E-03 0,02132123 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 1,000 2,446E-03 0,02124426 ! DNA integrity checkpoint GO:0031570 75 36 2,000 2,511E-03 0,02173453 ! lymphocyte differentiation GO:0030098 167 75 3,000 2,514E-03 0,02168128 ! glycogen metabolic process GO:0005977 61 37 2,000 2,718E-03 0,02335386 ! positive regulation of lymphocyte activation GO:0051251 127 77 3,000 2,767E-03 0,02368956 ! mitotic cell cycle checkpoint GO:0007093 76 38 2,000 2,935E-03 0,02503704 ! carbohydrate homeostasis GO:0033500 53 38 2,000 2,935E-03 0,02494857 GO:0042593|glucose homeostasis, ! embryonic epithelial tube formation GO:0001838 72 38 2,000 2,935E-03 0,02486073 ! positive regulation of leukocyte proliferation GO:0070665 62 38 2,000 2,935E-03 0,0247735 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 62 38 2,000 2,935E-03 0,02468688 GO:0006073|cellular glucan metabolic process, ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 2,975E-03 0,02493628 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,975E-03 0,02484969 ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 2,975E-03 0,02476371 ! regulation of intracellular pH GO:0051453 19 11 1,000 2,975E-03 0,02467831 ! neuroblast proliferation GO:0007405 24 11 1,000 2,975E-03 0,02459351 ! oocyte differentiation GO:0009994 18 11 1,000 2,975E-03 0,02450929 ! thymus development GO:0048538 27 11 1,000 2,975E-03 0,02442564 ! germ cell migration GO:0008354 25 11 1,000 2,975E-03 0,02434256 ! embryonic gut development GO:0048566 15 11 1,000 2,975E-03 0,02426004 ! cardiac cell differentiation GO:0035051 31 11 1,000 2,975E-03 0,02417808 ! regulation of embryonic development GO:0045995 27 11 1,000 2,975E-03 0,02409667 ! regulation of peptidase activity GO:0052547 134 79 3,000 3,036E-03 0,0245134 ! regulation of action potential in neuron GO:0019228 73 39 2,000 3,162E-03 0,02544039 ! T cell activation GO:0042110 168 81 3,000 3,323E-03 0,02665014 ! mesenchymal cell development GO:0014031 87 40 2,000 3,399E-03 0,02716993 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! response to nutrient GO:0007584 125 82 3,000 3,473E-03 0,02766937 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 3,552E-03 0,028203 ! virus-host interaction GO:0019048 29 12 1,000 3,552E-03 0,02811023 ! regulation of B cell proliferation GO:0030888 20 12 1,000 3,552E-03 0,02801806 ! hippocampus development GO:0021766 26 12 1,000 3,552E-03 0,0279265 ! fear response GO:0042596 26 12 1,000 3,552E-03 0,02783554 ! regulation of phagocytosis GO:0050764 16 12 1,000 3,552E-03 0,02774516 ! histone acetylation GO:0016573 26 12 1,000 3,552E-03 0,02765537 ! autonomic nervous system development GO:0048483 24 12 1,000 3,552E-03 0,02756616 ! gland morphogenesis GO:0022612 29 12 1,000 3,552E-03 0,02747752 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,552E-03 0,02738945 ! T cell homeostasis GO:0043029 25 12 1,000 3,552E-03 0,02730195 ! spleen development GO:0048536 22 12 1,000 3,552E-03 0,027215 ! digestive tract morphogenesis GO:0048546 26 12 1,000 3,552E-03 0,0271286 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of RNA splicing GO:0043484 20 12 1,000 3,552E-03 0,02704275 ! negative regulation of mast cell proliferation GO:0070667 23 12 1,000 3,552E-03 0,02695744 GO:0042130|negative regulation of T cell proliferation, ! regulation of T cell proliferation GO:0042129 71 41 2,000 3,647E-03 0,02759501 ! T cell differentiation GO:0030217 81 41 2,000 3,647E-03 0,02750851 ! keratinocyte differentiation GO:0030216 62 41 2,000 3,647E-03 0,02742255 ! negative regulation of transport GO:0051051 153 84 3,000 3,787E-03 0,02838413 ! negative regulation of growth GO:0045926 155 84 3,000 3,787E-03 0,02829598 ! regulation of intracellular protein transport GO:0033157 80 42 2,000 3,906E-03 0,02909667 ! neuron migration GO:0001764 79 42 2,000 3,906E-03 0,02900687 ! positive regulation of cell activation GO:0050867 145 85 3,000 3,951E-03 0,02924821 GO:0002696|positive regulation of leukocyte activation, ! tube morphogenesis GO:0035239 176 86 3,000 4,119E-03 0,03040313 ! energy reserve metabolic process GO:0006112 74 43 2,000 4,176E-03 0,03072634 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 4,176E-03 0,03063267 ! regulation of cell-cell adhesion GO:0022407 33 13 1,000 4,177E-03 0,0305448 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 4,177E-03 0,03045224 ! plasma membrane organization GO:0007009 24 13 1,000 4,177E-03 0,03036024 ! deoxyribonucleotide catabolic process GO:0009264 19 13 1,000 4,177E-03 0,03026879 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 1,000 4,177E-03 0,0301779 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! response to X-ray GO:0010165 25 13 1,000 4,177E-03 0,03008754 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 4,177E-03 0,02999773 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 4,177E-03 0,02990845 ! nucleoside triphosphate catabolic process GO:0009143 21 13 1,000 4,177E-03 0,0298197 ! regulation of cellular pH GO:0030641 22 13 1,000 4,177E-03 0,02973148 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 4,177E-03 0,02964377 ! positive regulation of protein modification process GO:0031401 136 88 3,000 4,471E-03 0,03164032 ! cellular defense response GO:0006968 114 89 3,000 4,654E-03 0,0328403 ! leukocyte migration GO:0050900 68 45 2,000 4,749E-03 0,03340996 ! ossification GO:0001503 188 90 3,000 4,843E-03 0,033969 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 4,849E-03 0,03391309 ! hair follicle morphogenesis GO:0031069 26 14 1,000 4,849E-03 0,03381479 ! regulation of mRNA processing GO:0050684 24 14 1,000 4,849E-03 0,03371706 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 4,849E-03 0,0336199 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 31 14 1,000 4,849E-03 0,03352329 ! bone development GO:0060348 189 91 3,000 5,036E-03 0,03471727 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 2,000 5,052E-03 0,03473204 ! regulation of gene-specific transcription GO:0032583 96 46 2,000 5,052E-03 0,03463309 ! epidermal cell differentiation GO:0009913 68 46 2,000 5,052E-03 0,0345347 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 5,567E-03 0,03794427 ! heterophilic cell adhesion GO:0007157 39 15 1,000 5,567E-03 0,03783709 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 5,567E-03 0,0377305 ! G1/S transition checkpoint GO:0031575 40 15 1,000 5,567E-03 0,03762452 ! cell killing GO:0001906 29 15 1,000 5,567E-03 0,03751913 ! lymphocyte homeostasis GO:0002260 30 15 1,000 5,567E-03 0,03741432 ! regulation of T cell activation GO:0050863 158 94 3,000 5,646E-03 0,03784249 ! positive regulation of cell cycle GO:0045787 89 48 2,000 5,694E-03 0,03805279 ! cellular component disassembly GO:0022411 86 48 2,000 5,694E-03 0,03794738 ! morphogenesis of embryonic epithelium GO:0016331 91 48 2,000 5,694E-03 0,03784255 ! activation of caspase activity GO:0006919 84 48 2,000 5,694E-03 0,03773831 ! regulation of action potential GO:0001508 95 49 2,000 6,032E-03 0,03986902 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 6,032E-03 0,03975979 ! regulation of protein localization GO:0032880 176 97 3,000 6,305E-03 0,0414451 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 6,331E-03 0,04150451 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 6,331E-03 0,04139173 ! filopodium assembly GO:0046847 32 16 1,000 6,331E-03 0,04127956 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 6,331E-03 0,04116799 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 1,000 6,331E-03 0,04105703 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 1,000 6,331E-03 0,04094666 ! DNA replication initiation GO:0006270 27 16 1,000 6,331E-03 0,04083688 ! negative regulation of leukocyte proliferation GO:0070664 31 16 1,000 6,331E-03 0,04072769 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 6,331E-03 0,04061908 ! regulation of ossification GO:0030278 117 50 2,000 6,382E-03 0,04083494 ! viral infectious cycle GO:0019058 99 51 2,000 6,743E-03 0,04303471 ! cellular amino acid biosynthetic process GO:0008652 75 51 2,000 6,743E-03 0,04292086 ! skeletal muscle tissue development GO:0007519 186 99 3,000 6,771E-03 0,04298121 GO:0060538|skeletal muscle organ development, ! regulation of muscle contraction GO:0006937 81 52 2,000 7,117E-03 0,04506053 ! positive regulation of growth GO:0045927 90 52 2,000 7,117E-03 0,04494226 ! cartilage development GO:0051216 90 52 2,000 7,117E-03 0,04482461 ! synapse organization GO:0050808 85 52 2,000 7,117E-03 0,04470758 ! metencephalon development GO:0022037 30 17 1,000 7,14E-03 0,04473399 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 1,000 7,14E-03 0,0446178 GO:0019692|deoxyribose phosphate metabolic process, ! limbic system development GO:0021761 36 17 1,000 7,14E-03 0,04450221 ! regulation of protein binding GO:0043393 33 17 1,000 7,14E-03 0,04438722 ! neural crest cell migration GO:0001755 37 17 1,000 7,14E-03 0,04427282 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 7,14E-03 0,04415901 ! microspike assembly GO:0030035 36 17 1,000 7,14E-03 0,04404578 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 2,000 7,502E-03 0,04616601 ! cell maturation GO:0048469 100 53 2,000 7,502E-03 0,04604824 ! regulation of neuron apoptosis GO:0043523 100 53 2,000 7,502E-03 0,04593107 ! activation of phospholipase C activity GO:0007202 103 54 2,000 7,9E-03 0,04824371 GO:0010863|positive regulation of phospholipase C activity, ! heterocycle catabolic process GO:0046700 85 54 2,000 7,9E-03 0,04812157 ! neuron maturation GO:0042551 42 18 1,000 7,992E-03 0,04855986 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 7,992E-03 0,04843754 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 1,000 7,992E-03 0,04831584 ! memory GO:0007613 31 18 1,000 7,992E-03 0,04819475 ! epidermis morphogenesis GO:0048730 40 18 1,000 7,992E-03 0,04807426 ! response to retinoic acid GO:0032526 26 18 1,000 7,992E-03 0,04795437 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 1,000 7,992E-03 0,04783508 ! long-chain fatty acid transport GO:0015909 31 18 1,000 7,992E-03 0,04771639 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 7,992E-03 0,04759828 ! nerve development GO:0021675 28 18 1,000 7,992E-03 0,04748075 ! positive regulation of caspase activity GO:0043280 95 55 2,000 8,31E-03 0,04924764 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 86 55 2,000 8,31E-03 0,04912663 ! positive regulation of phospholipase activity GO:0010518 104 55 2,000 8,31E-03 0,04900623 ! aging GO:0007568 103 55 2,000 8,31E-03 0,04888641 ! regulation of multicellular organism growth GO:0040014 85 55 2,000 8,31E-03 0,04876717 ! skeletal muscle fiber development GO:0048741 111 56 2,000 8,733E-03 0,05112082 ! nucleotide-excision repair GO:0006289 83 56 2,000 8,733E-03 0,05099674 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 1,000 8,889E-03 0,05178211 ! lipid phosphorylation GO:0046834 35 19 1,000 8,889E-03 0,05165703 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 8,889E-03 0,05153255 ! forelimb morphogenesis GO:0035136 32 19 1,000 8,889E-03 0,05140868 ! bile acid metabolic process GO:0008206 29 19 1,000 8,889E-03 0,0512854 ! pigmentation during development GO:0048066 41 19 1,000 8,889E-03 0,0511627 ! cellular response to unfolded protein GO:0034620 33 19 1,000 8,889E-03 0,0510406 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 1,000 8,889E-03 0,05091907 ! actin filament bundle formation GO:0051017 42 19 1,000 8,889E-03 0,05079812 ! prostaglandin metabolic process GO:0006693 37 19 1,000 8,889E-03 0,05067775 GO:0006692|prostanoid metabolic process, ! cellular pigmentation GO:0033059 36 19 1,000 8,889E-03 0,05055794 ! purine nucleotide catabolic process GO:0006195 29 19 1,000 8,889E-03 0,0504387 ! muscle fiber development GO:0048747 112 57 2,000 9,167E-03 0,05189778 ! regulation of intracellular transport GO:0032386 101 57 2,000 9,167E-03 0,05177595 ! regulation of bone remodeling GO:0046850 137 57 2,000 9,167E-03 0,0516547 ! regulation of phospholipase activity GO:0010517 106 57 2,000 9,167E-03 0,05153401 ! regulation of tissue remodeling GO:0034103 140 58 2,000 9,614E-03 0,0539217 ! positive regulation of lipase activity GO:0060193 108 58 2,000 9,614E-03 0,0537963 ! protein amino acid acetylation GO:0006473 39 20 1,000 9,828E-03 0,05486101 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 9,828E-03 0,05473402 ! response to vitamin GO:0033273 31 20 1,000 9,828E-03 0,05460761 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 9,828E-03 0,05448179 GO:0010675|regulation of cellular carbohydrate metabolic process, ! D-ribose metabolic process GO:0006014 29 20 1,000 9,828E-03 0,05435654 ! fatty acid beta-oxidation GO:0006635 34 20 1,000 9,828E-03 0,05423187 ! negative regulation of T cell activation GO:0050868 40 20 1,000 9,828E-03 0,05410777 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 9,828E-03 0,05398424 ! DNA catabolic process GO:0006308 86 59 2,000 0,01007414 0,05521272 ! DNA damage response, signal transduction GO:0042770 128 60 2,000 0,0105464 0,05766962 ! regulation of heart contraction GO:0008016 110 60 2,000 0,0105464 0,05753885 ! kidney development GO:0001822 122 60 2,000 0,0105464 0,05740867 ! ovarian follicle development GO:0001541 35 21 1,000 0,01080852 0,05870272 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 1,000 0,01080852 0,0585705 ! hindlimb morphogenesis GO:0035137 43 21 1,000 0,01080852 0,05843888 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 1,000 0,01080852 0,05830786 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 1,000 0,01080852 0,05817741 ! oogenesis GO:0048477 36 21 1,000 0,01080852 0,05804755 ! DNA modification GO:0006304 34 21 1,000 0,01080852 0,05791827 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 0,01080852 0,05778956 ! response to cytokine stimulus GO:0034097 63 21 1,000 0,01080852 0,05766143 ! collagen catabolic process GO:0030574 28 21 1,000 0,01080852 0,05753386 ! glycerophospholipid biosynthetic process GO:0046474 105 61 2,000 0,0110313 0,05859008 ! ear development GO:0043583 103 62 2,000 0,0115289 0,06109809 ! regulation of homeostatic process GO:0032844 134 62 2,000 0,0115289 0,06096381 ! positive regulation of protein catabolic process GO:0045732 38 22 1,000 0,01183084 0,06242323 ! glutamate signaling pathway GO:0007215 41 22 1,000 0,01183084 0,06228664 ! regeneration GO:0031099 41 22 1,000 0,01183084 0,06215064 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 0,01183084 0,06201524 ! deoxyribonucleotide metabolic process GO:0009262 32 22 1,000 0,01183084 0,06188042 ! renal system process GO:0003014 41 22 1,000 0,01183084 0,06174619 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 0,01183084 0,06161254 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 0,01183084 0,06147947 ! sarcomere organization GO:0045214 30 22 1,000 0,01183084 0,06134697 ! positive regulation of B cell activation GO:0050871 38 22 1,000 0,01183084 0,06121504 ! nucleoside monophosphate metabolic process GO:0009123 107 63 2,000 0,01203926 0,06215976 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 2,000 0,01256242 0,064722 ! myeloid leukocyte differentiation GO:0002573 40 23 1,000 0,01289383 0,0662875 ! viral genome replication GO:0019079 41 23 1,000 0,01289383 0,06614616 ! response to ethanol GO:0045471 46 23 1,000 0,01289383 0,06600542 ! sex determination GO:0007530 47 23 1,000 0,01289383 0,06586528 ! fatty acid transport GO:0015908 44 23 1,000 0,01289383 0,06572574 ! platelet activation GO:0030168 37 23 1,000 0,01289383 0,06558678 ! regulation of bone mineralization GO:0030500 49 23 1,000 0,01289383 0,06544841 ! positive regulation of DNA replication GO:0045740 43 23 1,000 0,01289383 0,06531063 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 0,01289383 0,06517342 ! protein amino acid O-linked glycosylation GO:0006493 42 23 1,000 0,01289383 0,06503679 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 0,01289383 0,06490073 ! regulation of cytokine biosynthetic process GO:0042035 95 65 2,000 0,01309843 0,06579294 ! actin filament organization GO:0007015 148 66 2,000 0,01364733 0,06840725 ! secondary metabolic process GO:0019748 116 66 2,000 0,01364733 0,06826504 ! developmental maturation GO:0021700 116 66 2,000 0,01364733 0,06812341 ! cell projection assembly GO:0030031 120 66 2,000 0,01364733 0,06798237 ! protein import into nucleus, translocation GO:0000060 46 24 1,000 0,01399683 0,06957926 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 0,01399683 0,0694358 ! regulation of cellular catabolic process GO:0031329 52 24 1,000 0,01399683 0,06929293 ! multicellular organismal response to stress GO:0033555 49 24 1,000 0,01399683 0,06915064 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 0,01399683 0,06900894 ! regulation of alpha-beta T cell activation GO:0046634 42 24 1,000 0,01399683 0,06886782 ! lymphocyte proliferation GO:0046651 48 24 1,000 0,01399683 0,06872727 ! pallium development GO:0021543 49 24 1,000 0,01399683 0,0685873 ! pentose metabolic process GO:0019321 35 24 1,000 0,01399683 0,06844789 ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 0,01399683 0,06830905 ! leukocyte homeostasis GO:0001776 44 24 1,000 0,01399683 0,06817078 ! lung development GO:0030324 144 67 2,000 0,01420917 0,06906519 ! positive regulation of T cell activation GO:0050870 109 67 2,000 0,01420917 0,06892594 ! regulation of lipase activity GO:0060191 130 68 2,000 0,01478398 0,07156994 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 1,000 0,01513918 0,07314228 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 0,01513918 0,07299571 ! negative regulation of DNA replication GO:0008156 42 25 1,000 0,01513918 0,07284972 ! receptor metabolic process GO:0043112 46 25 1,000 0,01513918 0,07270431 ! chromosome condensation GO:0030261 45 25 1,000 0,01513918 0,07255948 ! neural crest cell development GO:0014032 54 25 1,000 0,01513918 0,07241522 GO:0014033|neural crest cell differentiation, ! regulation of biomineral formation GO:0070167 51 25 1,000 0,01513918 0,07227154 ! somitogenesis GO:0001756 43 25 1,000 0,01513918 0,07212843 ! neural tube closure GO:0001843 49 25 1,000 0,01513918 0,07198588 GO:0060606|tube closure, ! liver development GO:0001889 53 25 1,000 0,01513918 0,0718439 ! urogenital system development GO:0001655 137 69 2,000 0,01537179 0,07280421 ! glycerolipid biosynthetic process GO:0045017 118 69 2,000 0,01537179 0,07266118 ! respiratory tube development GO:0030323 150 70 2,000 0,01597264 0,07535329 ! initiation of viral infection GO:0019059 57 26 1,000 0,01632023 0,0768424 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 1,000 0,01632023 0,07669231 ! molting cycle process GO:0022404 50 26 1,000 0,01632023 0,07654282 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! tube lumen formation GO:0035148 50 26 1,000 0,01632023 0,0763939 ! blastocyst development GO:0001824 49 26 1,000 0,01632023 0,07624556 ! leukocyte proliferation GO:0070661 52 26 1,000 0,01632023 0,0760978 GO:0032943|mononuclear cell proliferation, ! respiratory system development GO:0060541 153 72 2,000 0,01721354 0,0801079 ! spliceosomal snRNP biogenesis GO:0000387 36 27 1,000 0,01753933 0,08146649 ! protein amino acid acylation GO:0043543 55 27 1,000 0,01753933 0,08130952 ! multicellular organismal catabolic process GO:0044243 36 27 1,000 0,01753933 0,08115315 ! male gonad development GO:0008584 44 27 1,000 0,01753933 0,08099739 ! primary neural tube formation GO:0014020 51 27 1,000 0,01753933 0,08084222 ! regulation of chromosome organization GO:0033044 42 27 1,000 0,01753933 0,08068765 ! glutathione metabolic process GO:0006749 39 27 1,000 0,01753933 0,08053366 ! negative regulation of neuron differentiation GO:0045665 42 27 1,000 0,01753933 0,08038027 ! negative regulation of lymphocyte activation GO:0051250 53 27 1,000 0,01753933 0,08022745 ! learning or memory GO:0007611 147 73 2,000 0,01785364 0,08151018 ! lipid oxidation GO:0034440 43 28 1,000 0,01879587 0,08564934 GO:0019395|fatty acid oxidation, ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 2,000 0,01917323 0,08720376 ! cytosolic calcium ion homeostasis GO:0051480 135 76 2,000 0,01985274 0,09012396 ! regulation of catabolic process GO:0009894 161 76 2,000 0,01985274 0,08995424 ! regulation of pH GO:0006885 43 29 1,000 0,02008919 0,09085449 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 0,02008919 0,09068403 ! response to organic cyclic substance GO:0014070 55 29 1,000 0,02008919 0,09051421 ! negative regulation of neuron apoptosis GO:0043524 56 29 1,000 0,02008919 0,09034503 ! protein oligomerization GO:0051259 139 78 2,000 0,02125126 0,0953928 ! acute-phase response GO:0006953 49 30 1,000 0,02141869 0,09596529 ! myofibril assembly GO:0030239 47 30 1,000 0,02141869 0,09578692 GO:0055002|striated muscle cell development, ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 0,02141869 0,09560921 ! negative regulation of leukocyte activation GO:0002695 56 30 1,000 0,02141869 0,09543215 ! regulation of B cell activation GO:0050864 50 30 1,000 0,02141869 0,09525575 ! response to heat GO:0009408 50 30 1,000 0,02141869 0,09508 ! response to metal ion GO:0010038 140 80 2,000 0,02270247 0,10059328 ! collagen metabolic process GO:0032963 45 31 1,000 0,02278374 0,10076781 ! GPI anchor biosynthetic process GO:0006506 53 31 1,000 0,02278374 0,10058292 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 1,000 0,02278374 0,1003987 ! ovulation cycle process GO:0022602 49 31 1,000 0,02278374 0,10021515 ! positive regulation of T cell proliferation GO:0042102 52 31 1,000 0,02278374 0,10003228 ! iron ion homeostasis GO:0055072 54 31 1,000 0,02278374 0,09985007 ! fatty acid catabolic process GO:0009062 48 31 1,000 0,02278374 0,09966853 ! regulation of neuron differentiation GO:0045664 167 81 2,000 0,02344784 0,10238748 ! response to hydrogen peroxide GO:0042542 50 32 1,000 0,02418375 0,10540963 ! GPI anchor metabolic process GO:0006505 56 32 1,000 0,02418375 0,10521901 ! spliceosome assembly GO:0000245 67 32 1,000 0,02418375 0,10502909 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,02418375 0,10483984 ! muscle cell development GO:0055001 49 32 1,000 0,02418375 0,10465128 ! ovulation cycle GO:0042698 51 32 1,000 0,02418375 0,1044634 ! peripheral nervous system development GO:0007422 64 32 1,000 0,02418375 0,10427619 ! hindbrain development GO:0030902 61 32 1,000 0,02418375 0,10408965 ! response to drug GO:0042493 143 82 2,000 0,02420637 0,10400096 ! post-embryonic development GO:0009791 69 33 1,000 0,02561812 0,10987022 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,02561812 0,10967472 ! cell fate specification GO:0001708 52 33 1,000 0,02561812 0,10947991 ! negative regulation of protein transport GO:0051224 69 33 1,000 0,02561812 0,1092858 ! positive regulation of endocytosis GO:0045807 50 34 1,000 0,02708624 0,11534425 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 1,000 0,02708624 0,11514046 ! amine biosynthetic process GO:0009309 138 86 2,000 0,02737208 0,11615029 ! response to inorganic substance GO:0010035 153 86 2,000 0,02737208 0,1159458 ! nitrogen compound catabolic process GO:0044270 143 87 2,000 0,02819633 0,11922737 ! regulation of protein transport GO:0051223 154 87 2,000 0,02819633 0,1190182 GO:0070201|regulation of establishment of protein localization, ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,02858754 0,12045819 ! negative regulation of DNA metabolic process GO:0051053 61 35 1,000 0,02858754 0,1202476 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 0,02858754 0,12003774 ! female gonad development GO:0008585 58 35 1,000 0,02858754 0,11982862 ! telencephalon development GO:0021537 68 35 1,000 0,02858754 0,11962022 ! negative regulation of hydrolase activity GO:0051346 62 35 1,000 0,02858754 0,11941255 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,02858754 0,11920559 ! neural tube formation GO:0001841 67 35 1,000 0,02858754 0,11899935 ! gland development GO:0048732 206 88 2,000 0,02903369 0,12064777 ! positive regulation of cell development GO:0010720 80 36 1,000 0,03012144 0,12495204 ! embryonic organ development GO:0048568 57 36 1,000 0,03012144 0,12473697 ! negative regulation of cell activation GO:0050866 65 36 1,000 0,03012144 0,12452265 ! response to protein stimulus GO:0051789 149 91 2,000 0,03162417 0,13051071 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 1,000 0,03168736 0,13054758 ! establishment or maintenance of cell polarity GO:0007163 83 37 1,000 0,03168736 0,13032442 ! actomyosin structure organization GO:0031032 62 37 1,000 0,03168736 0,13010203 ! monovalent inorganic cation homeostasis GO:0055067 58 37 1,000 0,03168736 0,12988039 ! pigment metabolic process GO:0042440 80 37 1,000 0,03168736 0,1296595 ! phospholipid biosynthetic process GO:0008654 167 92 2,000 0,03251371 0,13281494 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,03328474 0,13573404 ! phosphoinositide biosynthetic process GO:0046489 67 38 1,000 0,03328474 0,13550437 ! development of primary female sexual characteristics GO:0046545 67 38 1,000 0,03328474 0,13527548 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 67 38 1,000 0,03328474 0,13504736 ! nucleotide catabolic process GO:0009166 61 38 1,000 0,03328474 0,13482001 ! isoprenoid metabolic process GO:0006720 66 38 1,000 0,03328474 0,13459342 ! negative regulation of multicellular organismal process GO:0051241 166 93 2,000 0,03341625 0,13489847 ! mammary gland development GO:0030879 86 39 1,000 0,03491302 0,14070474 ! learning GO:0007612 77 39 1,000 0,03491302 0,14046944 ! ear morphogenesis GO:0042471 60 39 1,000 0,03491302 0,14023494 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,03491302 0,14000121 ! segmentation GO:0035282 67 39 1,000 0,03491302 0,13976827 ! forebrain development GO:0030900 188 95 2,000 0,03526014 0,14092343 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,03657165 0,1459227 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,03712495 0,14788513 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,03712495 0,14764069 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03712495 0,14739706 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,03712495 0,14715423 ! neuron fate determination GO:0048664 7 5 0,000 0,03712495 0,1469122 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03712495 0,14667097 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,03712495 0,14643053 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,03712495 0,14619087 ! polyol transport GO:0015791 12 5 0,000 0,03712495 0,14595199 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,03712495 0,1457139 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03712495 0,14547658 ! response to superoxide GO:0000303 10 5 0,000 0,03712495 0,14524003 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03712495 0,14500425 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,03712495 0,14476924 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,03712495 0,14453498 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03712495 0,14430149 ! female meiosis GO:0007143 7 5 0,000 0,03712495 0,14406874 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03712495 0,14383675 ! cobalt ion transport GO:0006824 11 5 0,000 0,03712495 0,1436055 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,03712495 0,14337499 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,03712495 0,14314522 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,03712495 0,14291619 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03712495 0,14268789 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,03712495 0,14246032 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,03712495 0,14223347 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03712495 0,14200735 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,03712495 0,14178194 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,03712495 0,14155724 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03712495 0,14133326 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03712495 0,14110998 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03712495 0,14088741 ! negative chemotaxis GO:0050919 14 5 0,000 0,03712495 0,14066554 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03712495 0,14044437 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03712495 0,14022389 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,03712495 0,14000411 ! behavioral response to pain GO:0048266 9 5 0,000 0,03712495 0,13978501 ! clathrin coat assembly GO:0048268 14 5 0,000 0,03712495 0,13956659 ! Notch receptor processing GO:0007220 8 5 0,000 0,03712495 0,13934886 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03712495 0,13913181 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! micturition GO:0060073 9 5 0,000 0,03712495 0,13891543 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03712495 0,13869972 ! copulation GO:0007620 9 5 0,000 0,03712495 0,13848468 ! glial cell fate commitment GO:0021781 13 5 0,000 0,03712495 0,13827031 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,03712495 0,1380566 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03712495 0,13784355 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03712495 0,13763116 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03712495 0,13741942 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03712495 0,13720833 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03712495 0,13699788 ! grooming behavior GO:0007625 6 5 0,000 0,03712495 0,13678809 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03712495 0,13657893 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,03712495 0,13637041 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03712495 0,13616253 ! response to protozoan GO:0001562 10 5 0,000 0,03712495 0,13595528 ! lymph vessel development GO:0001945 10 5 0,000 0,03712495 0,13574866 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,03712495 0,13554267 ! endochondral ossification GO:0001958 16 5 0,000 0,03712495 0,1353373 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03712495 0,13513256 ! parathyroid gland development GO:0060017 13 5 0,000 0,03712495 0,13492843 ! anagen GO:0042640 6 5 0,000 0,03712495 0,13472492 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 0,000 0,03712495 0,13452202 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,03712495 0,13431973 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,03712495 0,13411805 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,03712495 0,13391697 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,03712495 0,1337165 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,03712495 0,13351662 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,03712495 0,13331734 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03712495 0,13311866 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03712495 0,13292057 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,03712495 0,13272306 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,03712495 0,13252614 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03712495 0,13232981 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03712495 0,13213405 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03712495 0,13193888 ! histidine catabolic process GO:0006548 6 5 0,000 0,03712495 0,13174428 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03712495 0,13155025 ! valine metabolic process GO:0006573 10 5 0,000 0,03712495 0,13135679 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03712495 0,13116391 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,03712495 0,13097158 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,03712495 0,13077982 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03712495 0,13058863 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,03712495 0,13039799 ! polyol catabolic process GO:0046174 7 5 0,000 0,03712495 0,1302079 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03712495 0,13001837 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03712495 0,12982939 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03712495 0,12964096 ! muscle cell migration GO:0014812 8 5 0,000 0,03712495 0,12945307 ! mitochondrial fission GO:0000266 8 5 0,000 0,03712495 0,12926573 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,03712495 0,12907893 ! mRNA transcription GO:0009299 9 5 0,000 0,03712495 0,12889267 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,03712495 0,12870695 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,03712495 0,12852176 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,03712495 0,1283371 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03712495 0,12815297 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03712495 0,12796937 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03712495 0,1277863 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03712495 0,12760374 ! response to food GO:0032094 6 5 0,000 0,03712495 0,12742171 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,03712495 0,1272402 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03712495 0,1270592 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,03712495 0,12687872 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03712495 0,12669875 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,03712495 0,12651929 ! forebrain neuron development GO:0021884 13 5 0,000 0,03712495 0,12634034 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03712495 0,12616189 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,03712495 0,12598395 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03712495 0,12580651 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03712495 0,12562956 GO:0009251|glucan catabolic process, ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03712495 0,12545312 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,03712495 0,12527717 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,03712495 0,12510171 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03712495 0,12492674 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,03712495 0,12475226 ! basic amino acid transport GO:0015802 11 5 0,000 0,03712495 0,12457827 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03712495 0,12440476 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,03712495 0,12423174 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03712495 0,12405919 ! depyrimidination GO:0045008 10 5 0,000 0,03712495 0,12388713 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03712495 0,12371554 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03712495 0,12354443 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,03712495 0,12337378 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 7 5 0,000 0,03712495 0,12320361 ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,03712495 0,12303391 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03712495 0,12286468 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03712495 0,12269591 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03712495 0,1225276 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,03712495 0,12235975 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,03712495 0,12219237 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03712495 0,12202544 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03712495 0,12185896 ! response to arsenic GO:0046685 10 5 0,000 0,03712495 0,12169294 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,03712495 0,12152737 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03712495 0,12136226 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,03712495 0,12119759 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,03712495 0,12103336 ! response to cadmium ion GO:0046686 7 5 0,000 0,03712495 0,12086958 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,03712495 0,12070624 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,03712495 0,12054335 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03712495 0,12038089 ! decidualization GO:0046697 11 5 0,000 0,03712495 0,12021887 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,03712495 0,12005729 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,03712495 0,11989613 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03712495 0,11973542 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,03712495 0,11957513 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03712495 0,11941527 ! neural tube patterning GO:0021532 7 5 0,000 0,03712495 0,11925583 ! embryonic cleavage GO:0040016 6 5 0,000 0,03712495 0,11909683 ! peroxisome fission GO:0016559 5 5 0,000 0,03712495 0,11893824 ! histone demethylation GO:0016577 10 5 0,000 0,03712495 0,11878008 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,03712495 0,11862234 ! mitotic recombination GO:0006312 9 5 0,000 0,03712495 0,11846501 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03712495 0,11830811 ! metaphase plate congression GO:0051310 7 5 0,000 0,03712495 0,11815161 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03712495 0,11799554 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03712495 0,11783987 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,03712495 0,11768461 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,03712495 0,11752976 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,03712495 0,11737532 ! muscle cell proliferation GO:0033002 11 5 0,000 0,03712495 0,11722129 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03712495 0,11706765 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,03712495 0,11691442 ! plasminogen activation GO:0031639 5 5 0,000 0,03712495 0,1167616 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,03712495 0,11660916 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03712495 0,11645713 ! metaphase GO:0051323 8 5 0,000 0,03712495 0,1163055 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,03712495 0,11615425 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03712495 0,1160034 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03712495 0,11585294 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03712495 0,11570288 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03712495 0,1155532 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03712495 0,1154039 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,03712495 0,11525499 ! response to redox state GO:0051775 5 5 0,000 0,03712495 0,11510647 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,03712495 0,11495833 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,03712495 0,11481057 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03712495 0,11466318 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,03712495 0,11451618 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03712495 0,11436955 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,03712495 0,1142233 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03712495 0,11407742 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,03712495 0,11393191 ! striatum development GO:0021756 9 5 0,000 0,03712495 0,11378678 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,03712495 0,11364201 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,03712495 0,11349761 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03712495 0,11335358 ! glial cell migration GO:0008347 11 5 0,000 0,03712495 0,11320991 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03712495 0,11306661 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03712495 0,11292367 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03712495 0,11278109 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03712495 0,11263887 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03712495 0,112497 ! neuroprotection GO:0043526 6 5 0,000 0,03712495 0,1123555 ! neural plate development GO:0001840 8 5 0,000 0,03712495 0,11221435 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,03712495 0,11207355 ! regulation of sensory perception GO:0051931 7 5 0,000 0,03712495 0,11193311 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03712495 0,11179302 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,03712495 0,11165328 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,03712495 0,11151388 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03712495 0,11137484 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03712495 0,11123614 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03712495 0,11109779 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03712495 0,11095978 ! spindle assembly GO:0051225 6 5 0,000 0,03712495 0,11082211 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,03712495 0,11068478 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,03712495 0,1105478 GO:0022011|myelination in the peripheral nervous system, ! drug metabolic process GO:0017144 6 5 0,000 0,03712495 0,11041115 ! stem cell division GO:0017145 11 5 0,000 0,03712495 0,11027484 GO:0048103|somatic stem cell division, ! organ regeneration GO:0031100 7 5 0,000 0,03712495 0,11013887 ! carnitine metabolic process GO:0009437 7 5 0,000 0,03712495 0,11000323 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,03712495 0,10986792 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03712495 0,10973295 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 1,000 0,03826008 0,1129494 ! female gamete generation GO:0007292 61 41 1,000 0,03826008 0,11281098 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,03997778 0,11773138 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 67 42 1,000 0,03997778 0,11758745 ! monocarboxylic acid transport GO:0015718 85 42 1,000 0,03997778 0,11744388 ! striated muscle cell differentiation GO:0051146 82 43 1,000 0,04172421 0,12242492 ! neural tube development GO:0021915 77 43 1,000 0,04172421 0,12227581 ! epithelial cell differentiation GO:0030855 79 43 1,000 0,04172421 0,12212705 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 1,000 0,04172421 0,12197866 ! glucose transport GO:0015758 65 43 1,000 0,04172421 0,12183063 ! phagocytosis GO:0006909 90 43 1,000 0,04172421 0,12168295 ! hexose transport GO:0008645 67 44 1,000 0,04349884 0,12670484 GO:0015749|monosaccharide transport, ! male sex differentiation GO:0046661 76 44 1,000 0,04349884 0,12655163 ! double-strand break repair GO:0006302 81 44 1,000 0,04349884 0,12639879 ! developmental growth GO:0048589 82 44 1,000 0,04349884 0,12624632 ! maintenance of location in cell GO:0051651 97 44 1,000 0,04349884 0,12609422 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,0443836 0,12850415 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,0443836 0,12834969 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,0443836 0,12819561 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,0443836 0,1280419 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,0443836 0,12788856 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,0443836 0,12773558 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,0443836 0,12758297 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,0443836 0,12743072 ! sleep GO:0030431 13 6 0,000 0,0443836 0,12727884 ! response to oxygen radical GO:0000305 11 6 0,000 0,0443836 0,12712732 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,0443836 0,12697615 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,0443836 0,12682535 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,0443836 0,12667491 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,0443836 0,12652482 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,0443836 0,12637508 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,0443836 0,1262257 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,0443836 0,12607668 ! forebrain regionalization GO:0021871 8 6 0,000 0,0443836 0,125928 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,0443836 0,12577968 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,0443836 0,1256317 ! response to zinc ion GO:0010043 9 6 0,000 0,0443836 0,12548407 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,0443836 0,12533679 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,0443836 0,12518985 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,0443836 0,12504326 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,0443836 0,12489701 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,0443836 0,1247511 ! malate metabolic process GO:0006108 11 6 0,000 0,0443836 0,12460554 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,0443836 0,12446031 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,0443836 0,12431542 ! protein refolding GO:0042026 15 6 0,000 0,0443836 0,12417087 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,0443836 0,12402665 ! opsonization GO:0008228 8 6 0,000 0,0443836 0,12388277 ! mating behavior GO:0007617 7 6 0,000 0,0443836 0,12373922 ! neuron remodeling GO:0016322 15 6 0,000 0,0443836 0,123596 ! erythrocyte maturation GO:0043249 7 6 0,000 0,0443836 0,12345312 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,0443836 0,12331056 ! equilibrioception GO:0050957 14 6 0,000 0,0443836 0,12316833 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,0443836 0,12302644 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,0443836 0,12288486 ! photoreceptor cell development GO:0042461 10 6 0,000 0,0443836 0,12274362 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,0443836 0,12260269 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,0443836 0,12246209 ! response to interferon-gamma GO:0034341 15 6 0,000 0,0443836 0,12232182 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,0443836 0,12218186 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,0443836 0,12204222 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,0443836 0,12190291 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,0443836 0,12176391 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,0443836 0,12162522 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,0443836 0,12148686 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,0443836 0,1213488 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,0443836 0,12121106 ! thymic T cell selection GO:0045061 12 6 0,000 0,0443836 0,12107363 ! protein lipoylation GO:0009249 10 6 0,000 0,0443836 0,12093652 ! cysteine metabolic process GO:0006534 10 6 0,000 0,0443836 0,12079971 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,0443836 0,12066322 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,0443836 0,12052703 ! glutamate catabolic process GO:0006538 10 6 0,000 0,0443836 0,12039115 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,0443836 0,12025557 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,0443836 0,1201203 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,0443836 0,11998533 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,0443836 0,11985067 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,0443836 0,11971631 ! hyperosmotic response GO:0006972 9 6 0,000 0,0443836 0,11958225 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,0443836 0,11944849 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,0443836 0,11931502 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,0443836 0,11918186 ! urea metabolic process GO:0019627 7 6 0,000 0,0443836 0,11904899 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,0443836 0,11891642 ! neutrophil activation GO:0042119 8 6 0,000 0,0443836 0,11878414 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,0443836 0,11865216 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,0443836 0,11852047 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,0443836 0,11838908 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,0443836 0,11825797 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,0443836 0,11812715 ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,0443836 0,11799663 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,0443836 0,11786639 ! T cell mediated immunity GO:0002456 16 6 0,000 0,0443836 0,11773643 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,0443836 0,11760677 GO:0010543|regulation of platelet activation, ! carnitine transport GO:0015879 10 6 0,000 0,0443836 0,11747739 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,0443836 0,11734829 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0443836 0,11721948 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,0443836 0,11709095 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,0443836 0,1169627 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,0443836 0,11683473 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,0443836 0,11670704 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,0443836 0,11657964 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,0443836 0,1164525 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,0443836 0,11632565 ! establishment of spindle localization GO:0051293 12 6 0,000 0,0443836 0,11619907 GO:0051653|spindle localization, ! response to UV-C GO:0010225 11 6 0,000 0,0443836 0,11607277 ! astrocyte development GO:0014002 15 6 0,000 0,0443836 0,11594674 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,0443836 0,11582098 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,0443836 0,1156955 ! regulation of dendrite development GO:0050773 16 6 0,000 0,0443836 0,11557029 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,0443836 0,11544535 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,0443836 0,11532068 ! response to copper ion GO:0046688 10 6 0,000 0,0443836 0,11519627 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,0443836 0,11507214 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,0443836 0,11494827 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,0443836 0,11482467 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,0443836 0,11470134 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,0443836 0,11457827 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,0443836 0,11445546 ! hair follicle maturation GO:0048820 7 6 0,000 0,0443836 0,11433292 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,0443836 0,11421064 ! Schwann cell development GO:0014044 15 6 0,000 0,0443836 0,11408862 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,0443836 0,11396686 ! subpallium development GO:0021544 10 6 0,000 0,0443836 0,11384536 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,0443836 0,11372412 ! histone ubiquitination GO:0016574 8 6 0,000 0,0443836 0,11360313 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,0443836 0,11348241 ! maintenance of organ identity GO:0048496 9 6 0,000 0,0443836 0,11336194 ! G2 phase GO:0051319 16 6 0,000 0,0443836 0,11324172 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,0443836 0,11312176 ! establishment of planar polarity GO:0001736 7 6 0,000 0,0443836 0,11300206 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,0443836 0,11288261 ! membrane to membrane docking GO:0022614 14 6 0,000 0,0443836 0,11276341 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,0443836 0,11264446 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,0443836 0,11252576 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,0443836 0,11240731 ! receptor internalization GO:0031623 10 6 0,000 0,0443836 0,11228911 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,0443836 0,11217116 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,0443836 0,11205346 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0443836 0,111936 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,0443836 0,11181879 ! protein deubiquitination GO:0016579 14 6 0,000 0,0443836 0,11170183 ! protein destabilization GO:0031648 9 6 0,000 0,0443836 0,11158511 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,0443836 0,11146863 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,0443836 0,11135239 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,0443836 0,1112364 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,0443836 0,11112065 ! progesterone metabolic process GO:0042448 10 6 0,000 0,0443836 0,11100514 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,0443836 0,11088987 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,0443836 0,11077484 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,0443836 0,11066005 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,0443836 0,11054549 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,0443836 0,11043117 ! determination of adult lifespan GO:0008340 15 6 0,000 0,0443836 0,11031709 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,0443836 0,11020325 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,0443836 0,11008963 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,0443836 0,10997626 ! catecholamine transport GO:0051937 9 6 0,000 0,0443836 0,10986311 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,0443836 0,1097502 ! sensory cilium assembly GO:0035058 10 6 0,000 0,0443836 0,10963752 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,0443836 0,10952507 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,0443836 0,10941285 ! maternal placenta development GO:0001893 12 6 0,000 0,0443836 0,10930087 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,0443836 0,10918911 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,0443836 0,10907757 ! negative regulation of B cell activation GO:0050869 13 6 0,000 0,0443836 0,10896627 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,0443836 0,10885519 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,0443836 0,10874434 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,0443836 0,10863372 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,0443836 0,10852332 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,04530115 0,11065439 ! branching morphogenesis of a tube GO:0048754 97 45 1,000 0,04530115 0,11054216 ! polysaccharide biosynthetic process GO:0000271 70 45 1,000 0,04530115 0,11043017 ! icosanoid metabolic process GO:0006690 80 45 1,000 0,04530115 0,11031839 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,04713064 0,11465755 ! response to calcium ion GO:0051592 81 47 1,000 0,04898679 0,11905274 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,04898679 0,1189326 ! tRNA transcription GO:0009304 14 7 0,000 0,05158778 0,12512116 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,05158778 0,12499516 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,05158778 0,12486941 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,05158778 0,12474391 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,05158778 0,12461867 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,05158778 0,12449367 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,05158778 0,12436893 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,05158778 0,12424444 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,05158778 0,12412019 ! prostate gland development GO:0030850 13 7 0,000 0,05158778 0,1239962 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,05158778 0,12387245 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05158778 0,12374894 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,05158778 0,12362569 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,05158778 0,12350268 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05158778 0,12337991 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,05158778 0,12325739 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,05158778 0,12313511 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,05158778 0,12301307 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,05158778 0,12289128 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,05158778 0,12276972 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,05158778 0,12264841 ! glycolipid transport GO:0046836 10 7 0,000 0,05158778 0,12252734 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,05158778 0,1224065 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,05158778 0,1222859 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,05158778 0,12216554 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,05158778 0,12204542 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,05158778 0,12192553 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,05158778 0,12180588 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,05158778 0,12168646 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,05158778 0,12156728 ! mRNA stabilization GO:0048255 18 7 0,000 0,05158778 0,12144833 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 14 7 0,000 0,05158778 0,12132961 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,05158778 0,12121112 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,05158778 0,12109287 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,05158778 0,12097485 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05158778 0,12085705 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,05158778 0,12073949 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05158778 0,12062215 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05158778 0,12050504 ! rhythmic behavior GO:0007622 15 7 0,000 0,05158778 0,12038816 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,05158778 0,1202715 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,05158778 0,12015507 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,05158778 0,12003887 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,05158778 0,11992289 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,05158778 0,11980713 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,05158778 0,1196916 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,05158778 0,11957629 ! mechanosensory behavior GO:0007638 14 7 0,000 0,05158778 0,1194612 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,05158778 0,11934634 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05158778 0,11923169 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,05158778 0,11911727 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05158778 0,11900306 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05158778 0,11888907 ! spinal cord patterning GO:0021511 13 7 0,000 0,05158778 0,1187753 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,05158778 0,11866175 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,05158778 0,11854842 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,05158778 0,1184353 ! adrenal gland development GO:0030325 17 7 0,000 0,05158778 0,11832239 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,05158778 0,11820971 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,05158778 0,11809723 ! ovulation GO:0030728 9 7 0,000 0,05158778 0,11798497 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,05158778 0,11787293 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,05158778 0,11776109 ! microtubule nucleation GO:0007020 20 7 0,000 0,05158778 0,11764947 ! proline biosynthetic process GO:0006561 10 7 0,000 0,05158778 0,11753806 ! thyroid hormone generation GO:0006590 13 7 0,000 0,05158778 0,11742686 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,05158778 0,11731587 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,05158778 0,11720509 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,05158778 0,11709452 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05158778 0,11698416 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05158778 0,116874 ! galactose metabolic process GO:0006012 13 7 0,000 0,05158778 0,11676406 ! vesicle fusion GO:0006906 17 7 0,000 0,05158778 0,11665432 ! response to dietary excess GO:0002021 8 7 0,000 0,05158778 0,11654478 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,05158778 0,11643545 ! intracellular pH reduction GO:0051452 11 7 0,000 0,05158778 0,11632633 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,05158778 0,11621741 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,05158778 0,11610869 ! nucleoside transport GO:0015858 8 7 0,000 0,05158778 0,11600018 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,05158778 0,11589187 ! parturition GO:0007567 14 7 0,000 0,05158778 0,11578376 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,05158778 0,11567585 ! rRNA modification GO:0000154 14 7 0,000 0,05158778 0,11556815 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,05158778 0,11546064 ! spindle checkpoint GO:0031577 15 7 0,000 0,05158778 0,11535334 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,05158778 0,11524623 ! macrophage differentiation GO:0030225 11 7 0,000 0,05158778 0,11513932 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05158778 0,11503261 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,05158778 0,1149261 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,05158778 0,11481979 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,05158778 0,11471367 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,05158778 0,11460775 ! fibrinolysis GO:0042730 10 7 0,000 0,05158778 0,11450202 ! eating behavior GO:0042755 7 7 0,000 0,05158778 0,11439649 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,05158778 0,11429115 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,05158778 0,11418601 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,05158778 0,11408106 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,05158778 0,1139763 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,05158778 0,11387174 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,05158778 0,11376736 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,05158778 0,11366318 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,05158778 0,11355919 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,05158778 0,11345539 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,05158778 0,11335177 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,05158778 0,11324835 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,05158778 0,11314512 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,05158778 0,11304207 ! regulation of meiosis GO:0040020 12 7 0,000 0,05158778 0,11293921 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,05158778 0,11283654 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,05158778 0,11273405 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,05158778 0,11263175 ! oxygen homeostasis GO:0032364 12 7 0,000 0,05158778 0,11252964 ! transcription termination GO:0006353 13 7 0,000 0,05158778 0,11242771 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,05158778 0,11232597 ! anaphase GO:0051322 17 7 0,000 0,05158778 0,1122244 GO:0000090|mitotic anaphase, ! axonal fasciculation GO:0007413 18 7 0,000 0,05158778 0,11212303 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,05158778 0,11202183 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,05158778 0,11192082 ! diuresis GO:0030146 12 7 0,000 0,05158778 0,11181999 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,05158778 0,11171934 ! thiamin metabolic process GO:0006772 7 7 0,000 0,05158778 0,11161888 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05158778 0,11151859 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,05158778 0,11141848 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,05158778 0,11131856 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,05158778 0,11121881 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05158778 0,11111924 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05158778 0,11101985 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05158778 0,11092064 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,05158778 0,1108216 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,05158778 0,11072274 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,05158778 0,11062406 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,05158778 0,11052555 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,05158778 0,11042722 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05158778 0,11032906 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,05158778 0,11023108 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,05158778 0,11013327 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,05158778 0,11003563 ! adult feeding behavior GO:0008343 9 7 0,000 0,05158778 0,10993817 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,05158778 0,10984088 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,05158778 0,10974376 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,05158778 0,10964681 ! muscle adaptation GO:0043500 14 7 0,000 0,05158778 0,10955004 ! embryonic heart tube development GO:0035050 10 7 0,000 0,05158778 0,10945343 ! retina homeostasis GO:0001895 12 7 0,000 0,05158778 0,109357 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,05158778 0,10926073 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,05158778 0,10916464 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,05158778 0,10906871 ! protein prenylation GO:0018342 18 7 0,000 0,05158778 0,10897295 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,05158778 0,10887736 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,05158778 0,10878194 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05158778 0,10868668 ! protein amino acid lipidation GO:0006497 95 49 1,000 0,05277707 0,11109504 ! peptide metabolic process GO:0006518 76 49 1,000 0,05277707 0,11099793 ! response to temperature stimulus GO:0009266 76 49 1,000 0,05277707 0,11090099 ! unsaturated fatty acid metabolic process GO:0033559 86 49 1,000 0,05277707 0,11080421 ! DNA-dependent DNA replication GO:0006261 74 49 1,000 0,05277707 0,11070761 ! ribonucleoprotein complex assembly GO:0022618 95 49 1,000 0,05277707 0,11061117 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,05277707 0,11051491 ! histone modification GO:0016570 91 50 1,000 0,05471022 0,11446329 ! negative regulation of immune system process GO:0002683 95 50 1,000 0,05471022 0,11436384 ! positive regulation of binding GO:0051099 78 51 1,000 0,05666806 0,11835359 ! response to estrogen stimulus GO:0043627 93 51 1,000 0,05666806 0,11825095 ! chromatin remodeling GO:0006338 109 51 1,000 0,05666806 0,11814848 ! vesicle organization GO:0016050 107 51 1,000 0,05666806 0,11804618 ! regulation of cell shape GO:0008360 125 51 1,000 0,05666806 0,11794407 ! regulation of angiogenesis GO:0045765 114 52 1,000 0,05865011 0,12196383 ! covalent chromatin modification GO:0016569 101 52 1,000 0,05865011 0,12185851 ! morphogenesis of a branching structure GO:0001763 111 52 1,000 0,05865011 0,12175337 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,05873788 0,12183046 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,05873788 0,12172553 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,05873788 0,12162077 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05873788 0,1215162 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05873788 0,1214118 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,05873788 0,12130759 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,05873788 0,12120355 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,05873788 0,12109969 ! meiotic prophase I GO:0007128 13 8 0,000 0,05873788 0,12099601 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05873788 0,1208925 ! oligopeptide transport GO:0006857 15 8 0,000 0,05873788 0,12078918 ! UTP metabolic process GO:0046051 8 8 0,000 0,05873788 0,12068603 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,05873788 0,12058305 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,05873788 0,12048025 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,05873788 0,12037763 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05873788 0,12027518 ! succinate metabolic process GO:0006105 14 8 0,000 0,05873788 0,12017291 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05873788 0,1200708 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,05873788 0,11996888 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,05873788 0,11986712 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,05873788 0,11976554 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05873788 0,11966413 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05873788 0,11956289 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,05873788 0,11946182 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,05873788 0,11936093 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,05873788 0,1192602 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05873788 0,11915964 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,05873788 0,11905926 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,05873788 0,11895904 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,05873788 0,11885899 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05873788 0,11875911 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,05873788 0,11865939 ! astrocyte differentiation GO:0048708 18 8 0,000 0,05873788 0,11855985 ! histidine metabolic process GO:0006547 16 8 0,000 0,05873788 0,11846047 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05873788 0,11836125 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,05873788 0,11826221 ! glycine catabolic process GO:0006546 13 8 0,000 0,05873788 0,11816333 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,05873788 0,11806461 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,05873788 0,11796606 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,05873788 0,11786767 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,05873788 0,11776945 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05873788 0,11767139 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,05873788 0,11757349 ! macrophage activation GO:0042116 12 8 0,000 0,05873788 0,11747576 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05873788 0,11737819 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,05873788 0,11728078 ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,05873788 0,11718353 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,05873788 0,11708644 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,05873788 0,11698952 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05873788 0,11689275 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,05873788 0,11679615 ! osteoblast development GO:0002076 16 8 0,000 0,05873788 0,1166997 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,05873788 0,11660341 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,05873788 0,11650729 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,05873788 0,11641132 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,05873788 0,1163155 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,05873788 0,11621985 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05873788 0,11612435 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,05873788 0,11602901 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05873788 0,11593383 ! intermediate filament organization GO:0045109 12 8 0,000 0,05873788 0,1158388 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,05873788 0,11574393 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,05873788 0,11564921 ! cellular extravasation GO:0045123 12 8 0,000 0,05873788 0,11555465 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,05873788 0,11546024 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,05873788 0,11536599 ! response to antibiotic GO:0046677 11 8 0,000 0,05873788 0,11527189 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,05873788 0,11517794 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,05873788 0,11508415 ! response to tropane GO:0014073 15 8 0,000 0,05873788 0,11499051 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05873788 0,11489702 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,05873788 0,11480369 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05873788 0,1147105 ! mast cell activation GO:0045576 14 8 0,000 0,05873788 0,11461747 ! multicellular organismal aging GO:0010259 18 8 0,000 0,05873788 0,11452458 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,05873788 0,11443185 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,05873788 0,11433927 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05873788 0,11424684 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05873788 0,11415455 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,05873788 0,11406242 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05873788 0,11397043 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05873788 0,1138786 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,05873788 0,11378691 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,05873788 0,11369536 ! intracellular lipid transport GO:0032365 13 8 0,000 0,05873788 0,11360397 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05873788 0,11351272 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05873788 0,11342162 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,05873788 0,11333066 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,05873788 0,11323985 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05873788 0,11314919 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,05873788 0,11305867 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,05873788 0,1129683 ! hormone catabolic process GO:0042447 17 8 0,000 0,05873788 0,11287806 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05873788 0,11278798 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,05873788 0,11269804 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,05873788 0,11260824 ! ATP catabolic process GO:0006200 11 8 0,000 0,05873788 0,11251858 ! blastocyst growth GO:0001832 19 8 0,000 0,05873788 0,11242907 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05873788 0,1123397 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,05873788 0,11225047 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05873788 0,11216138 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05873788 0,11207243 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,05873788 0,11198363 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,05873788 0,11189496 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,05873788 0,11180644 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,05873788 0,11171805 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,05873788 0,11162981 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,05873788 0,1115417 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05873788 0,11145374 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,05873788 0,11136591 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05873788 0,11127822 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05873788 0,11119067 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,05873788 0,11110325 ! NAD biosynthetic process GO:0009435 13 8 0,000 0,05873788 0,11101598 ! lipoprotein biosynthetic process GO:0042158 101 53 1,000 0,0606559 0,11455109 ! chloride transport GO:0006821 90 55 1,000 0,06473683 0,12216221 ! regulation of protein catabolic process GO:0042176 116 55 1,000 0,06473683 0,12206647 ! heart morphogenesis GO:0003007 97 55 1,000 0,06473683 0,12197089 ! axon extension GO:0048675 15 9 0,000 0,06583431 0,12394159 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,06583431 0,12384469 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,06583431 0,12374793 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,06583431 0,12365133 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06583431 0,12355488 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,06583431 0,12345858 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,06583431 0,12336243 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,06583431 0,12326642 ! phosphate transport GO:0006817 19 9 0,000 0,06583431 0,12317057 ! reproductive behavior GO:0019098 19 9 0,000 0,06583431 0,12307487 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06583431 0,12297931 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,06583431 0,12288391 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06583431 0,12278865 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,06583431 0,12269354 ! GTP metabolic process GO:0046039 9 9 0,000 0,06583431 0,12259857 ! RNA methylation GO:0001510 15 9 0,000 0,06583431 0,12250375 ! elastic fiber assembly GO:0048251 15 9 0,000 0,06583431 0,12240908 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,06583431 0,12231456 ! artery development GO:0060840 24 9 0,000 0,06583431 0,12222018 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,06583431 0,12212595 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,06583431 0,12203186 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,06583431 0,12193792 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,06583431 0,12184412 ! chemosensory behavior GO:0007635 20 9 0,000 0,06583431 0,12175046 ! microtubule bundle formation GO:0001578 21 9 0,000 0,06583431 0,12165695 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,06583431 0,12156359 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06583431 0,12147036 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,06583431 0,12137728 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,06583431 0,12128435 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,06583431 0,12119155 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06583431 0,1210989 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06583431 0,12100638 ! protein targeting to ER GO:0045047 22 9 0,000 0,06583431 0,12091401 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,06583431 0,12082178 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,06583431 0,12072969 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,06583431 0,12063774 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06583431 0,12054593 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,06583431 0,12045426 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06583431 0,12036273 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06583431 0,12027134 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06583431 0,12018009 ! mannose metabolic process GO:0006013 13 9 0,000 0,06583431 0,12008897 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,06583431 0,119998 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,06583431 0,11990716 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,06583431 0,11981646 ! receptor clustering GO:0043113 18 9 0,000 0,06583431 0,11972589 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,06583431 0,11963546 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06583431 0,11954517 ! ruffle organization GO:0031529 15 9 0,000 0,06583431 0,11945502 ! retinol metabolic process GO:0042572 18 9 0,000 0,06583431 0,119365 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,06583431 0,11927512 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,06583431 0,11918537 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,06583431 0,11909576 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,06583431 0,11900628 GO:0030204|chondroitin sulfate metabolic process, ! oligodendrocyte development GO:0014003 10 9 0,000 0,06583431 0,11891693 ! segment specification GO:0007379 13 9 0,000 0,06583431 0,11882772 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06583431 0,11873865 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,06583431 0,1186497 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06583431 0,11856089 ! response to amine stimulus GO:0014075 13 9 0,000 0,06583431 0,11847222 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06583431 0,11838367 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,06583431 0,11829526 ! erythrocyte development GO:0048821 15 9 0,000 0,06583431 0,11820698 ! gas homeostasis GO:0033483 16 9 0,000 0,06583431 0,11811883 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06583431 0,11803082 ! renal water homeostasis GO:0003091 14 9 0,000 0,06583431 0,11794293 ! postreplication repair GO:0006301 22 9 0,000 0,06583431 0,11785517 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,06583431 0,11776755 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,06583431 0,11768006 ! icosanoid secretion GO:0032309 15 9 0,000 0,06583431 0,11759269 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,06583431 0,11750546 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06583431 0,11741835 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,06583431 0,11733137 ! regulation of cell division GO:0051302 15 9 0,000 0,06583431 0,11724453 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,06583431 0,11715781 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,06583431 0,11707122 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06583431 0,11698475 ! sterol catabolic process GO:0016127 11 9 0,000 0,06583431 0,11689842 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06583431 0,11681221 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,06583431 0,11672613 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,06583431 0,11664017 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,06583431 0,11655435 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,06583431 0,11646864 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,06583431 0,11638307 ! musculoskeletal movement GO:0050881 14 9 0,000 0,06583431 0,11629762 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,06583431 0,11621229 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,06583431 0,11612709 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06583431 0,11604202 ! purine base metabolic process GO:0006144 21 9 0,000 0,06583431 0,11595707 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,06583431 0,11587224 ! pigment granule transport GO:0051904 17 9 0,000 0,06583431 0,11578754 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,06583431 0,11570296 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,06583431 0,11561851 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06583431 0,11553418 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06583431 0,11544997 ! maintenance of location GO:0051235 118 57 1,000 0,0689072 0,12075071 ! regulation of endocytosis GO:0030100 91 58 1,000 0,0710248 0,12437093 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,07287748 0,12752233 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,07287748 0,12742966 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,07287748 0,12733712 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,07287748 0,12724471 ! synapsis GO:0007129 13 10 0,000 0,07287748 0,12715244 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,07287748 0,1270603 ! N-glycan processing GO:0006491 20 10 0,000 0,07287748 0,12696829 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,07287748 0,12687642 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,07287748 0,12678468 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,07287748 0,12669307 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,07287748 0,1266016 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,07287748 0,12651025 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,07287748 0,12641904 ! androgen metabolic process GO:0008209 17 10 0,000 0,07287748 0,12632796 ! phospholipid efflux GO:0033700 16 10 0,000 0,07287748 0,12623701 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,07287748 0,12614619 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,07287748 0,12605551 ! lung alveolus development GO:0048286 26 10 0,000 0,07287748 0,12596495 ! pathogenesis GO:0009405 13 10 0,000 0,07287748 0,12587452 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07287748 0,12578423 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,07287748 0,12569406 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,07287748 0,12560402 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,07287748 0,12551411 ! endoderm development GO:0007492 16 10 0,000 0,07287748 0,12542433 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,07287748 0,12533467 ! arginine catabolic process GO:0006527 13 10 0,000 0,07287748 0,12524515 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,07287748 0,12515575 ! proline metabolic process GO:0006560 13 10 0,000 0,07287748 0,12506648 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,07287748 0,12497734 ! V(D)J recombination GO:0033151 28 10 0,000 0,07287748 0,12488833 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07287748 0,12479944 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,07287748 0,12471068 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,07287748 0,12462204 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,07287748 0,12453353 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,07287748 0,12444515 ! multicellular organism growth GO:0035264 18 10 0,000 0,07287748 0,12435689 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,07287748 0,12426875 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,07287748 0,12418074 ! epithelial cell development GO:0002064 20 10 0,000 0,07287748 0,12409286 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,07287748 0,1240051 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,07287748 0,12391746 ! macroautophagy GO:0016236 17 10 0,000 0,07287748 0,12382995 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,07287748 0,12374256 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,07287748 0,1236553 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,07287748 0,12356815 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,07287748 0,12348113 ! copper ion homeostasis GO:0055070 13 10 0,000 0,07287748 0,12339424 ! regulation of bone resorption GO:0045124 25 10 0,000 0,07287748 0,12330746 ! brain morphogenesis GO:0048854 23 10 0,000 0,07287748 0,12322081 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,07287748 0,12313428 ! blastoderm segmentation GO:0007350 18 10 0,000 0,07287748 0,12304787 ! response to dsRNA GO:0043331 20 10 0,000 0,07287748 0,12296158 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07287748 0,12287541 ! melanosome localization GO:0032400 16 10 0,000 0,07287748 0,12278936 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,07287748 0,12270344 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,07287748 0,12261763 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,07287748 0,12253194 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,07287748 0,12244638 ! mRNA cleavage GO:0006379 17 10 0,000 0,07287748 0,12236093 ! protein sumoylation GO:0016925 15 10 0,000 0,07287748 0,1222756 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,07287748 0,12219039 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07287748 0,1221053 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,07287748 0,12202033 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,07287748 0,12193547 ! salivary gland development GO:0007431 27 10 0,000 0,07287748 0,12185074 ! prophase GO:0051324 15 10 0,000 0,07287748 0,12176612 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07287748 0,12168162 ! apical protein localization GO:0045176 15 10 0,000 0,07287748 0,12159723 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,07287748 0,12151297 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,07287748 0,12142882 ! positive regulation of leukocyte migration GO:0002687 25 10 0,000 0,07287748 0,12134478 ! midbrain development GO:0030901 13 10 0,000 0,07287748 0,12126086 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07287748 0,12117706 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,07287748 0,12109338 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,07287748 0,12100981 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,07287748 0,12092635 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,07287748 0,12084301 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,07287748 0,12075979 ! detection of calcium ion GO:0005513 23 10 0,000 0,07287748 0,12067668 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,07287748 0,12059368 ! cerebellar cortex development GO:0021695 15 10 0,000 0,07287748 0,1205108 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,07287748 0,12042803 ! activation of innate immune response GO:0002218 12 10 0,000 0,07287748 0,12034537 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,07287748 0,12026283 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,07287748 0,1201804 ! establishment of cell polarity GO:0030010 16 10 0,000 0,07287748 0,12009809 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,07287748 0,12001589 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,07287748 0,1199338 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,07316342 0,12032207 ! regulation of Rab protein signal transduction GO:0032483 92 59 1,000 0,07316342 0,12023988 GO:0032313|regulation of Rab GTPase activity, ! mesoderm development GO:0007498 119 61 1,000 0,07750199 0,12728314 ! gonad development GO:0008406 98 62 1,000 0,0797011 0,13080548 ! respiratory burst GO:0045730 17 11 0,000 0,07986777 0,13098968 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,07986777 0,13090045 ! neuron fate specification GO:0048665 17 11 0,000 0,07986777 0,13081134 ! telencephalon cell migration GO:0022029 20 11 0,000 0,07986777 0,13072235 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,07986777 0,13063349 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,07986777 0,13054474 ! thyroid gland development GO:0030878 26 11 0,000 0,07986777 0,13045612 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,07986777 0,13036761 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,07986777 0,13027923 ! response to pain GO:0048265 24 11 0,000 0,07986777 0,13019096 ! T cell proliferation GO:0042098 26 11 0,000 0,07986777 0,13010282 ! blood vessel remodeling GO:0001974 29 11 0,000 0,07986777 0,13001479 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 0,000 0,07986777 0,12992688 ! bone resorption GO:0045453 16 11 0,000 0,07986777 0,12983909 ! ventral spinal cord development GO:0021517 21 11 0,000 0,07986777 0,12975142 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07986777 0,12966387 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07986777 0,12957644 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,07986777 0,12948912 ! melanocyte differentiation GO:0030318 21 11 0,000 0,07986777 0,12940193 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,07986777 0,12931485 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,07986777 0,12922788 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,07986777 0,12914103 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,07986777 0,1290543 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,07986777 0,12896769 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,07986777 0,12888119 ! UV protection GO:0009650 19 11 0,000 0,07986777 0,12879481 ! adult heart development GO:0007512 14 11 0,000 0,07986777 0,12870855 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07986777 0,1286224 ! temperature homeostasis GO:0001659 17 11 0,000 0,07986777 0,12853636 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,07986777 0,12845044 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,07986777 0,12836464 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,07986777 0,12827895 ! regulation of organ growth GO:0046620 13 11 0,000 0,07986777 0,12819337 ! pigment granule localization GO:0051875 20 11 0,000 0,07986777 0,12810791 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,07986777 0,12802256 ! vasoconstriction GO:0042310 18 11 0,000 0,07986777 0,12793732 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,07986777 0,1278522 ! embryonic axis specification GO:0000578 18 11 0,000 0,07986777 0,12776719 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,07986777 0,1276823 ! snRNA metabolic process GO:0016073 24 11 0,000 0,07986777 0,12759752 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07986777 0,12751285 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,07986777 0,12742829 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,07986777 0,12734384 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,07986777 0,12725951 ! zymogen activation GO:0031638 15 11 0,000 0,07986777 0,12717529 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,07986777 0,12709118 ! nucleosome positioning GO:0016584 15 11 0,000 0,07986777 0,12700718 ! regulation of isotype switching GO:0045191 22 11 0,000 0,07986777 0,12692329 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,07986777 0,12683951 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,07986777 0,12675584 ! regulation of leukocyte migration GO:0002685 26 11 0,000 0,07986777 0,12667229 ! acid secretion GO:0046717 18 11 0,000 0,07986777 0,12658884 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07986777 0,1265055 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,07986777 0,12642228 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,07986777 0,12633916 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,07986777 0,12625615 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,07986777 0,12617325 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,07986777 0,12609046 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,07986777 0,12600778 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07986777 0,1259252 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,07986777 0,12584274 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,07986777 0,12576038 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,07986777 0,12567813 ! defense response to fungus GO:0050832 13 11 0,000 0,07986777 0,12559599 ! developmental induction GO:0031128 19 11 0,000 0,07986777 0,12551395 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,07986777 0,12543202 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07986777 0,1253502 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,07986777 0,12526849 ! sequestering of metal ion GO:0051238 14 11 0,000 0,07986777 0,12518688 ! lamellipodium assembly GO:0030032 20 11 0,000 0,07986777 0,12510538 ! nucleus localization GO:0051647 19 11 0,000 0,07986777 0,12502398 ! regulation of synapse organization GO:0050807 17 11 0,000 0,07986777 0,12494269 ! regulation of mitosis GO:0007088 105 63 1,000 0,08191952 0,12806911 GO:0051783|regulation of nuclear division, ! detection of external stimulus GO:0009581 91 63 1,000 0,08191952 0,12798595 ! multicellular organism reproduction GO:0032504 111 64 1,000 0,08415684 0,13139608 GO:0048609|reproductive process in a multicellular organism, ! germ cell development GO:0007281 118 65 1,000 0,08641266 0,13483066 ! myeloid cell differentiation GO:0030099 111 65 1,000 0,08641266 0,13474327 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,08680559 0,1352683 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,08680559 0,13518075 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,08680559 0,13509331 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,08680559 0,13500598 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,08680559 0,13491877 ! cartilage condensation GO:0001502 20 12 0,000 0,08680559 0,13483167 ! mating GO:0007618 17 12 0,000 0,08680559 0,13474468 ! protein complex disassembly GO:0043241 27 12 0,000 0,08680559 0,1346578 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,08680559 0,13457104 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,08680559 0,13448439 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,08680559 0,13439785 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,08680559 0,13431142 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08680559 0,1342251 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,08680559 0,13413889 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,08680559 0,1340528 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,08680559 0,13396681 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,08680559 0,13388093 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,08680559 0,13379517 ! drug transport GO:0015893 16 12 0,000 0,08680559 0,13370951 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,08680559 0,13362396 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,08680559 0,13353853 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,08680559 0,1334532 ! polyamine metabolic process GO:0006595 17 12 0,000 0,08680559 0,13336798 ! mitotic spindle organization GO:0007052 21 12 0,000 0,08680559 0,13328287 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,08680559 0,13319787 ! forebrain cell migration GO:0021885 21 12 0,000 0,08680559 0,13311297 ! asymmetric protein localization GO:0008105 20 12 0,000 0,08680559 0,13302819 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,08680559 0,13294351 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,08680559 0,13285894 ! entry into host cell GO:0030260 32 12 0,000 0,08680559 0,13277448 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,08680559 0,13269012 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08680559 0,13260588 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,08680559 0,13252174 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,08680559 0,1324377 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,08680559 0,13235377 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08680559 0,13226995 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,08680559 0,13218624 ! protein homotetramerization GO:0051289 21 12 0,000 0,08680559 0,13210263 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,08680559 0,13201912 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08680559 0,13193573 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,08680559 0,13185243 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,08680559 0,13176925 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08680559 0,13168616 ! cranial nerve development GO:0021545 20 12 0,000 0,08680559 0,13160319 ! fucose catabolic process GO:0019317 22 12 0,000 0,08680559 0,13152031 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,08680559 0,13143754 ! histone methylation GO:0016571 26 12 0,000 0,08680559 0,13135488 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,08680559 0,13127232 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,08680559 0,13118986 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,08680559 0,1311075 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,08680559 0,13102525 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,08680559 0,13094311 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,08680559 0,13086106 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,08680559 0,13077912 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 0,000 0,08680559 0,13069728 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,08680559 0,13061554 ! response to cold GO:0009409 17 12 0,000 0,08680559 0,13053391 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,08680559 0,13045238 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,08680559 0,13037095 ! extracellular matrix organization GO:0030198 133 66 1,000 0,08868658 0,13311286 ! activation of MAPK activity GO:0000187 115 67 1,000 0,09097819 0,13646729 ! chromosome segregation GO:0007059 113 67 1,000 0,09097819 0,13638226 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,09097819 0,13629734 ! amino acid transport GO:0006865 125 68 1,000 0,09328711 0,13966944 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 1,000 0,09328711 0,13958258 ! cGMP metabolic process GO:0046068 18 13 0,000 0,09369133 0,14010027 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,09369133 0,14001325 ! regulation of chemokine production GO:0032642 18 13 0,000 0,09369133 0,13992634 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,09369133 0,13983954 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,09369133 0,13975285 ! lipid localization GO:0010876 28 13 0,000 0,09369133 0,13966626 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,09369133 0,13957978 ! organelle fusion GO:0048284 32 13 0,000 0,09369133 0,1394934 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,09369133 0,13940714 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,09369133 0,13932098 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,09369133 0,13923492 ! endocrine pancreas development GO:0031018 22 13 0,000 0,09369133 0,13914898 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,09369133 0,13906313 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,09369133 0,1389774 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,09369133 0,13889177 ! methionine metabolic process GO:0006555 27 13 0,000 0,09369133 0,13880624 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,09369133 0,13872082 ! Golgi organization GO:0007030 24 13 0,000 0,09369133 0,13863551 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,09369133 0,1385503 ! cytokine metabolic process GO:0042107 22 13 0,000 0,09369133 0,1384652 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,09369133 0,1383802 ! exocrine system development GO:0035272 32 13 0,000 0,09369133 0,1382953 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,09369133 0,13821051 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,09369133 0,13812582 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,09369133 0,13804124 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,09369133 0,13795676 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,09369133 0,13787238 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,09369133 0,13778811 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,09369133 0,13770393 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,09369133 0,13761987 ! ribosome assembly GO:0042255 17 13 0,000 0,09369133 0,1375359 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,09369133 0,13745204 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,09369133 0,13736828 ! chromatin silencing GO:0006342 26 13 0,000 0,09369133 0,13728462 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,09369133 0,13720106 ! regulation of epidermis development GO:0045682 19 13 0,000 0,09369133 0,1371176 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09369133 0,13703425 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,09369133 0,136951 ! regulation of mRNA stability GO:0043488 31 13 0,000 0,09369133 0,13686784 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,09369133 0,13678479 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,09369133 0,13670184 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,09369133 0,13661899 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,09369133 0,13653624 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,09369133 0,1364536 ! embryonic placenta development GO:0001892 23 13 0,000 0,09369133 0,13637105 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,09369133 0,1362886 ! insulin secretion GO:0030073 23 13 0,000 0,09369133 0,13620625 ! actin filament polymerization GO:0030041 24 13 0,000 0,09369133 0,136124 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,09369133 0,13604185 ! acrosome reaction GO:0007340 18 13 0,000 0,09369133 0,13595979 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 1,000 0,09561294 0,1386647 ! reproductive structure development GO:0048608 113 71 1,000 0,10031382 0,1453946 ! humoral immune response GO:0006959 109 71 1,000 0,10031382 0,14530707 ! rRNA transcription GO:0009303 25 14 0,000 0,10052537 0,1455259 ! lactation GO:0007595 26 14 0,000 0,10052537 0,14543839 ! reproductive cellular process GO:0048610 20 14 0,000 0,10052537 0,14535099 ! tRNA modification GO:0006400 20 14 0,000 0,10052537 0,14526369 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,10052537 0,1451765 ! regulation of S phase GO:0033261 23 14 0,000 0,10052537 0,14508941 ! water transport GO:0006833 21 14 0,000 0,10052537 0,14500243 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,10052537 0,14491555 ! non-recombinational repair GO:0000726 25 14 0,000 0,10052537 0,14482877 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,10052537 0,1447421 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,10052537 0,14465553 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,10052537 0,14456907 ! RNA polyadenylation GO:0043631 30 14 0,000 0,10052537 0,14448271 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,10052537 0,14439645 ! palate development GO:0060021 31 14 0,000 0,10052537 0,14431029 ! regulated secretory pathway GO:0045055 23 14 0,000 0,10052537 0,14422424 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,10052537 0,14413829 ! arginine metabolic process GO:0006525 17 14 0,000 0,10052537 0,14405244 ! regulation of heart rate GO:0002027 24 14 0,000 0,10052537 0,1439667 ! organic alcohol transport GO:0015850 29 14 0,000 0,10052537 0,14388105 ! actin cytoskeleton reorganization GO:0031532 33 14 0,000 0,10052537 0,14379551 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,10052537 0,14371007 ! embryo implantation GO:0007566 30 14 0,000 0,10052537 0,14362473 ! neutral amino acid transport GO:0015804 26 14 0,000 0,10052537 0,1435395 ! L-amino acid transport GO:0015807 30 14 0,000 0,10052537 0,14345436 ! bone mineralization GO:0030282 17 14 0,000 0,10052537 0,14336932 ! stem cell development GO:0048864 43 14 0,000 0,10052537 0,14328439 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,10052537 0,14319956 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10052537 0,14311482 ! cerebellum development GO:0021549 21 14 0,000 0,10052537 0,14303019 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,10052537 0,14294566 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,10052537 0,14286122 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,10052537 0,14277689 ! cofactor transport GO:0051181 26 14 0,000 0,10052537 0,14269266 ! NADP metabolic process GO:0006739 24 14 0,000 0,10052537 0,14260852 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,10052537 0,14252448 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,10052537 0,14244055 ! intestinal absorption GO:0050892 25 14 0,000 0,10052537 0,14235671 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,10052537 0,14227297 ! oxygen transport GO:0015671 21 14 0,000 0,10052537 0,14218933 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,10052537 0,14210579 ! male genitalia development GO:0030539 24 14 0,000 0,10052537 0,14202234 ! regulation of RNA stability GO:0043487 32 14 0,000 0,10052537 0,141939 ! regulation of axon extension GO:0030516 37 14 0,000 0,10052537 0,14185575 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,10052537 0,1417726 ! acute inflammatory response GO:0002526 113 72 1,000 0,10268811 0,1447379 ! carbohydrate transport GO:0008643 110 72 1,000 0,10268811 0,14465316 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 1,000 0,10268811 0,14456851 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 1,000 0,10268811 0,14448397 ! regulation of blood pressure GO:0008217 125 73 1,000 0,10507781 0,14775992 ! lipoprotein metabolic process GO:0042157 131 73 1,000 0,10507781 0,14767361 ! axon guidance GO:0007411 139 73 1,000 0,10507781 0,1475874 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10730811 0,15063204 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,10730811 0,15054421 ! superoxide anion generation GO:0042554 20 15 0,000 0,10730811 0,15045648 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,10730811 0,15036885 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,10730811 0,15028132 ! copper ion transport GO:0006825 20 15 0,000 0,10730811 0,1501939 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,10730811 0,15010658 ! sulfate transport GO:0008272 23 15 0,000 0,10730811 0,15001936 ! response to cAMP GO:0051591 22 15 0,000 0,10730811 0,14993224 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,10730811 0,14984522 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,10730811 0,1497583 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,10730811 0,14967149 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,10730811 0,14958477 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,10730811 0,14949816 ! response to hexose stimulus GO:0009746 22 15 0,000 0,10730811 0,14941164 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,10730811 0,14932523 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,10730811 0,14923891 ! pituitary gland development GO:0021983 29 15 0,000 0,10730811 0,1491527 ! vesicle coating GO:0006901 33 15 0,000 0,10730811 0,14906658 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,10730811 0,14898056 ! regulation of exocytosis GO:0017157 22 15 0,000 0,10730811 0,14889465 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,10730811 0,14880883 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,10730811 0,14872311 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,10730811 0,14863749 ! regulation of vasodilation GO:0042312 26 15 0,000 0,10730811 0,14855197 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,10730811 0,14846654 ! histone deacetylation GO:0016575 20 15 0,000 0,10730811 0,14838122 ! mRNA splice site selection GO:0006376 38 15 0,000 0,10730811 0,14829599 ! tissue regeneration GO:0042246 26 15 0,000 0,10730811 0,14821086 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,10730811 0,14812583 ! water homeostasis GO:0030104 27 15 0,000 0,10730811 0,14804089 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10730811 0,14795606 ! muscle maintenance GO:0046716 26 15 0,000 0,10730811 0,14787132 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,10730811 0,14778667 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,10730811 0,14770213 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,10730811 0,14761768 ! dopamine metabolic process GO:0042417 35 15 0,000 0,10730811 0,14753332 ! heme biosynthetic process GO:0006783 29 15 0,000 0,10730811 0,14744907 ! detection of bacterium GO:0016045 18 15 0,000 0,10730811 0,14736491 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,10730811 0,14728084 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,10730811 0,14719687 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,10730811 0,147113 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,10730811 0,14702922 ! peptide hormone processing GO:0016486 23 15 0,000 0,10730811 0,14694554 ! regulation of transcription factor activity GO:0051090 126 74 1,000 0,10748256 0,14710071 GO:0090046|regulation of transcription regulator activity, ! meiosis GO:0007126 121 74 1,000 0,10748256 0,14701708 GO:0051327|M phase of meiotic cell cycle, ! organelle localization GO:0051640 136 74 1,000 0,10748256 0,14693355 ! regulation of vesicle-mediated transport GO:0060627 119 75 1,000 0,109902 0,15015571 ! meiotic cell cycle GO:0051321 122 75 1,000 0,109902 0,15007049 ! rhythmic process GO:0048511 128 75 1,000 0,109902 0,14998537 ! development of primary sexual characteristics GO:0045137 124 76 1,000 0,11233576 0,15321986 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,11403993 0,15545612 ! G1 phase of mitotic cell cycle GO:0000080 35 16 0,000 0,11403993 0,1553681 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,11403993 0,15528017 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,11403993 0,15519234 ! bone remodeling GO:0046849 27 16 0,000 0,11403993 0,15510461 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,11403993 0,15501698 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,11403993 0,15492945 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,11403993 0,15484202 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,11403993 0,15475469 ! startle response GO:0001964 28 16 0,000 0,11403993 0,15466745 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,11403993 0,15458032 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,11403993 0,15449328 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,11403993 0,15440634 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,11403993 0,15431949 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,11403993 0,15423275 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,11403993 0,1541461 ! protein polyubiquitination GO:0000209 34 16 0,000 0,11403993 0,15405955 ! glutamate metabolic process GO:0006536 22 16 0,000 0,11403993 0,1539731 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,11403993 0,15388674 ! response to osmotic stress GO:0006970 25 16 0,000 0,11403993 0,15380048 ! negative regulation of microtubule depolymerization GO:0007026 46 16 0,000 0,11403993 0,15371432 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 26 16 0,000 0,11403993 0,15362825 ! fructose metabolic process GO:0006000 25 16 0,000 0,11403993 0,15354228 ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,11403993 0,15345641 ! intermediate filament-based process GO:0045103 32 16 0,000 0,11403993 0,15337063 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,11403993 0,15328495 ! negative regulation of immune response GO:0050777 35 16 0,000 0,11403993 0,15319936 ! axon cargo transport GO:0008088 43 16 0,000 0,11403993 0,15311387 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,11403993 0,15302848 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,11403993 0,15294318 ! neuron recognition GO:0008038 35 16 0,000 0,11403993 0,15285797 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,11403993 0,15277286 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,11403993 0,15268785 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,11403993 0,15260293 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,11403993 0,1525181 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,11403993 0,15243337 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,11403993 0,15234873 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,11403993 0,15226418 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,11403993 0,15217973 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,11403993 0,15209538 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,11403993 0,15201111 ! neuropeptide signaling pathway GO:0007218 107 77 1,000 0,1147835 0,15291755 ! positive regulation of ligase activity GO:0051351 124 77 1,000 0,1147835 0,15283293 ! blood coagulation GO:0007596 146 78 1,000 0,11724488 0,15602388 GO:0050817|coagulation, ! response to steroid hormone stimulus GO:0048545 137 78 1,000 0,11724488 0,15593763 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,11971954 0,159141 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,11971954 0,15905313 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,1207212 0,16029536 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,1207212 0,16020695 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,1207212 0,16011863 ! negative regulation of cell cycle process GO:0010948 32 17 0,000 0,1207212 0,16003041 ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,1207212 0,15994229 ! signal complex assembly GO:0007172 41 17 0,000 0,1207212 0,15985426 ! gene silencing by RNA GO:0031047 36 17 0,000 0,1207212 0,15976634 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,1207212 0,1596785 ! glial cell development GO:0021782 27 17 0,000 0,1207212 0,15959077 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,1207212 0,15950313 ! adult walking behavior GO:0007628 33 17 0,000 0,1207212 0,15941559 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,1207212 0,15932814 ! heart looping GO:0001947 30 17 0,000 0,1207212 0,15924079 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,1207212 0,15915353 ! myoblast differentiation GO:0045445 45 17 0,000 0,1207212 0,15906637 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,1207212 0,15897931 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,1207212 0,15889234 ! glycine metabolic process GO:0006544 28 17 0,000 0,1207212 0,15880547 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,1207212 0,15871869 ! NAD metabolic process GO:0019674 29 17 0,000 0,1207212 0,158632 ! membrane budding GO:0006900 37 17 0,000 0,1207212 0,15854541 ! DNA integration GO:0015074 29 17 0,000 0,1207212 0,15845892 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,1207212 0,15837252 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,1207212 0,15828621 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,1207212 0,1582 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,1207212 0,15811388 ! genitalia development GO:0048806 30 17 0,000 0,1207212 0,15802786 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,1207212 0,15794192 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,1207212 0,15785609 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,1207212 0,15777034 ! steroid catabolic process GO:0006706 31 17 0,000 0,1207212 0,15768469 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,1207212 0,15759913 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,1207212 0,15751366 ! gas transport GO:0015669 25 17 0,000 0,1207212 0,15742829 ! organic cation transport GO:0015695 31 17 0,000 0,1207212 0,15734301 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,1207212 0,15725782 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,1207212 0,15717273 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,1207212 0,15708772 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 0,000 0,1207212 0,15700281 ! muscle cell differentiation GO:0042692 159 80 1,000 0,12220716 0,1588495 ! cellular lipid catabolic process GO:0044242 134 80 1,000 0,12220716 0,15876373 ! protein import into nucleus GO:0006606 158 80 1,000 0,12220716 0,15867805 ! inorganic anion transport GO:0015698 138 80 1,000 0,12220716 0,15859246 ! nuclear import GO:0051170 161 81 1,000 0,12470739 0,16174986 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,1273523 0,1650914 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,1273523 0,1650025 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,1273523 0,16491369 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,1273523 0,16482498 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,1273523 0,16473637 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,1273523 0,16464784 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,1273523 0,16455942 ! patterning of blood vessels GO:0001569 39 18 0,000 0,1273523 0,16447109 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,1273523 0,16438285 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,1273523 0,16429471 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,1273523 0,16420667 ! glutamine metabolic process GO:0006541 29 18 0,000 0,1273523 0,16411871 ! response to fungus GO:0009620 21 18 0,000 0,1273523 0,16403086 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,1273523 0,16394309 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,1273523 0,16385542 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,1273523 0,16376785 ! vitamin transport GO:0051180 27 18 0,000 0,1273523 0,16368036 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,1273523 0,16359297 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,1273523 0,16350568 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,1273523 0,16341847 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,1273523 0,16333136 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,1273523 0,16324435 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,1273523 0,16315742 ! hemostasis GO:0007599 158 84 1,000 0,13228054 0,16938105 ! regulation of ligase activity GO:0051340 142 84 1,000 0,13228054 0,16929095 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,13228054 0,16920095 ! protein secretion GO:0009306 39 19 0,000 0,13393362 0,17122438 ! positive regulation of translation GO:0045727 30 19 0,000 0,13393362 0,17113345 ! negative regulation of defense response GO:0031348 25 19 0,000 0,13393362 0,17104261 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,13393362 0,17095188 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,13393362 0,17086123 ! skin development GO:0043588 36 19 0,000 0,13393362 0,17077069 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,13393362 0,17068024 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,13393362 0,17058988 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,13393362 0,17049962 ! cerebral cortex development GO:0021987 36 19 0,000 0,13393362 0,17040946 ! heme metabolic process GO:0042168 36 19 0,000 0,13393362 0,17031939 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,13393362 0,17022942 ! plasma membrane fusion GO:0045026 28 19 0,000 0,13393362 0,17013954 ! regulation of endothelial cell migration GO:0010594 44 19 0,000 0,13393362 0,17004975 ! peptide cross-linking GO:0018149 37 19 0,000 0,13393362 0,16996007 ! protein export from nucleus GO:0006611 36 19 0,000 0,13393362 0,16987047 ! heart process GO:0003015 30 19 0,000 0,13393362 0,16978097 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,13393362 0,16969157 ! visual learning GO:0008542 36 19 0,000 0,13393362 0,16960226 ! G1 phase GO:0051318 40 19 0,000 0,13393362 0,16951304 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,13393362 0,16942391 ! cell-cell junction organization GO:0045216 35 19 0,000 0,13393362 0,16933488 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,13393362 0,16924595 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,13393362 0,16915711 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,13393362 0,16906836 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,13393362 0,1689797 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,13393362 0,16889113 ! cilium assembly GO:0042384 37 19 0,000 0,13393362 0,16880266 ! peptide hormone secretion GO:0030072 31 19 0,000 0,13393362 0,16871429 ! response to unfolded protein GO:0006986 131 85 1,000 0,134828 0,16975205 ! amine transport GO:0015837 155 86 1,000 0,13738648 0,17288277 ! protein localization in nucleus GO:0034504 176 87 1,000 0,13995566 0,17602369 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,14046552 0,17657264 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,14046552 0,17648043 ! positive regulation of ossification GO:0045778 47 20 0,000 0,14046552 0,17638833 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,14046552 0,17629631 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,14046552 0,1762044 ! cAMP metabolic process GO:0046058 36 20 0,000 0,14046552 0,17611258 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,14046552 0,17602085 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,14046552 0,17592922 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,14046552 0,17583769 ! retinoid metabolic process GO:0001523 32 20 0,000 0,14046552 0,17574625 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,14046552 0,1756549 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,14046552 0,17556365 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,14046552 0,1754725 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,14046552 0,17538144 GO:0032392|DNA geometric change, ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,14046552 0,17529047 ! body fluid secretion GO:0007589 31 20 0,000 0,14046552 0,1751996 ! peptide secretion GO:0002790 35 20 0,000 0,14046552 0,17510882 ! stem cell differentiation GO:0048863 53 20 0,000 0,14046552 0,17501814 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,14046552 0,17492755 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,14046552 0,17483706 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,14046552 0,17474666 ! sensory perception of pain GO:0019233 30 20 0,000 0,14046552 0,17465635 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,14046552 0,17456613 ! diencephalon development GO:0021536 34 20 0,000 0,14046552 0,17447601 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,14046552 0,17438598 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,14046552 0,17429605 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,14046552 0,1742062 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,14046552 0,17411645 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,14046552 0,17402679 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,14046552 0,17393723 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,14046552 0,17384775 ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,14046552 0,17375837 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,14046552 0,17366908 ! actin filament-based movement GO:0030048 43 20 0,000 0,14046552 0,17357988 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,14046552 0,17349078 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,14046552 0,17340176 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,14046552 0,17331284 ! regulation of DNA binding GO:0051101 155 88 1,000 0,14253524 0,17577641 ! regulation of neurological system process GO:0031644 148 88 1,000 0,14253524 0,17568636 ! regulation of cell morphogenesis GO:0022604 215 89 1,000 0,14512492 0,17878677 ! regulation of cell killing GO:0031341 42 21 0,000 0,14694837 0,18094052 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,14694837 0,18084796 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,14694837 0,18075551 ! hormone secretion GO:0046879 38 21 0,000 0,14694837 0,18066314 ! glycerol metabolic process GO:0006071 34 21 0,000 0,14694837 0,18057087 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,14694837 0,1804787 ! axis specification GO:0009798 38 21 0,000 0,14694837 0,18038662 ! smooth muscle contraction GO:0006939 46 21 0,000 0,14694837 0,18029463 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,14694837 0,18020274 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,14694837 0,18011094 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,14694837 0,18001923 ! cytolysis GO:0019835 24 21 0,000 0,14694837 0,17992762 ! vasodilation GO:0042311 39 21 0,000 0,14694837 0,1798361 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,14694837 0,17974467 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,14694837 0,17965334 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,14694837 0,1795621 ! collagen fibril organization GO:0030199 59 21 0,000 0,14694837 0,17947095 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,14694837 0,17937989 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,14694837 0,17928893 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,14694837 0,17919806 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,14694837 0,17910728 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,14694837 0,17901659 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,14694837 0,178926 ! sperm-egg recognition GO:0035036 21 21 0,000 0,14694837 0,17883549 ! regulation of cell cycle process GO:0010564 149 90 1,000 0,1477244 0,17968904 ! sex differentiation GO:0007548 145 90 1,000 0,1477244 0,17959824 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,15338253 0,18638302 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,15338253 0,18628893 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,15338253 0,18619494 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,15338253 0,18610105 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,15338253 0,18600725 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,15338253 0,18591354 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,15338253 0,18581993 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,15338253 0,18572641 ! sensory perception of taste GO:0050909 28 22 0,000 0,15338253 0,18563299 ! vacuolar transport GO:0007034 36 22 0,000 0,15338253 0,18553966 ! lysosome organization GO:0007040 41 22 0,000 0,15338253 0,18544642 ! central nervous system neuron development GO:0021954 46 22 0,000 0,15338253 0,18535328 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,15338253 0,18526023 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,15338253 0,18516727 ! fucose metabolic process GO:0006004 39 22 0,000 0,15338253 0,18507441 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,15338253 0,18498164 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,15338253 0,18488897 GO:0060415|muscle tissue morphogenesis, ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,15338253 0,18479638 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,15338253 0,18470389 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,15338253 0,18461149 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,15338253 0,18451919 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,15338253 0,18442697 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 0,000 0,15338253 0,18433485 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 0,000 0,15338253 0,18424282 ! protein stabilization GO:0050821 39 22 0,000 0,15338253 0,18415089 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 1,000 0,15557876 0,18669451 GO:0010498|proteasomal protein catabolic process, ! carbohydrate biosynthetic process GO:0016051 141 93 1,000 0,15557876 0,18660145 ! female pregnancy GO:0007565 164 94 1,000 0,15821457 0,18966829 ! transcription initiation GO:0006352 153 94 1,000 0,15821457 0,18957383 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,15976838 0,19134033 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,15976838 0,19124514 ! gluconeogenesis GO:0006094 33 23 0,000 0,15976838 0,19115004 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,15976838 0,19105504 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,15976838 0,19096013 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,15976838 0,19086531 GO:0006044|N-acetylglucosamine metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,15976838 0,19077059 ! visual behavior GO:0007632 42 23 0,000 0,15976838 0,19067596 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,15976838 0,19058142 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,15976838 0,19048698 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,15976838 0,19039264 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,15976838 0,19029838 ! vesicle targeting GO:0006903 43 23 0,000 0,15976838 0,19020422 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,15976838 0,19011015 GO:0051693|actin filament capping, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,15976838 0,19001618 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,15976838 0,1899223 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,15976838 0,18982851 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,15976838 0,18973481 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,15976838 0,18964121 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,15976838 0,1895477 ! hormone transport GO:0009914 40 23 0,000 0,15976838 0,18945428 ! cell-cell recognition GO:0009988 25 23 0,000 0,15976838 0,18936095 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,15976838 0,18926772 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,15976838 0,18917457 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,15976838 0,18908152 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,15976838 0,18898856 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,15976838 0,18889569 ! detection of stimulus GO:0051606 151 96 1,000 0,16351103 0,19322571 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,16610628 0,19619622 GO:0016444|somatic cell DNA recombination, ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,16610628 0,19609995 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,16610628 0,19600378 ! vesicle docking GO:0048278 47 24 0,000 0,16610628 0,1959077 ! spinal cord development GO:0021510 47 24 0,000 0,16610628 0,19581171 ! vacuole organization GO:0007033 43 24 0,000 0,16610628 0,19571582 ! digestive system process GO:0022600 39 24 0,000 0,16610628 0,19562002 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,16610628 0,19552432 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,16610628 0,19542871 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,16610628 0,19533319 ! membrane depolarization GO:0051899 39 24 0,000 0,16610628 0,19523776 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,16610628 0,19514243 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,16610628 0,1950472 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,16610628 0,19495205 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,16610628 0,194857 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,16610628 0,19476204 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,16610628 0,19466717 ! regulation of amine transport GO:0051952 40 24 0,000 0,16610628 0,1945724 ! protein ubiquitination GO:0016567 217 97 1,000 0,16617115 0,19455366 ! carboxylic acid catabolic process GO:0046395 156 98 1,000 0,16883882 0,19758084 GO:0016054|organic acid catabolic process, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 1,000 0,1715138 0,20061362 ! Golgi vesicle transport GO:0048193 207 99 1,000 0,1715138 0,20051614 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,17239657 0,20145029 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,17239657 0,2013525 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,17239657 0,20125481 ! phototransduction GO:0007602 33 25 0,000 0,17239657 0,20115721 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,17239657 0,2010597 GO:0006479|protein amino acid methylation, ! vasculogenesis GO:0001570 46 25 0,000 0,17239657 0,20096229 ! sperm motility GO:0030317 31 25 0,000 0,17239657 0,20086497 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,17239657 0,20076774 ! osteoblast differentiation GO:0001649 60 25 0,000 0,17239657 0,20067061 ! coenzyme catabolic process GO:0009109 39 25 0,000 0,17239657 0,20057358 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,17239657 0,20047663 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,17239657 0,20037979 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 0,000 0,17239657 0,20028303 ! immunoglobulin production GO:0002377 55 25 0,000 0,17239657 0,20018637 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,17239657 0,2000898 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,17239657 0,19999333 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,17239657 0,19989694 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,17239657 0,19980065 ! telomere organization GO:0032200 43 25 0,000 0,17239657 0,19970446 GO:0000723|telomere maintenance, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,17863963 0,20683684 ! embryonic pattern specification GO:0009880 44 26 0,000 0,17863963 0,20673735 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,17863963 0,20663795 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,17863963 0,20653866 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,17863963 0,20643945 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,17863963 0,20634035 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,17863963 0,20624134 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,17863963 0,20614242 ! regulation of transcription factor import into nucleus GO:0042990 54 26 0,000 0,17863963 0,2060436 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,17863963 0,20594487 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,17863963 0,20584624 GO:0051297|centrosome organization, ! regulation of endothelial cell proliferation GO:0001936 57 26 0,000 0,17863963 0,2057477 ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,17863963 0,20564926 ! cellular response to oxidative stress GO:0034599 39 26 0,000 0,17863963 0,20555091 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,17863963 0,20545265 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,17863963 0,20535449 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,17863963 0,20525642 ! positive regulation of nuclear division GO:0051785 40 26 0,000 0,17863963 0,20515845 GO:0045840|positive regulation of mitosis, ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,17863963 0,20506057 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,17863963 0,20496278 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,17863963 0,20486508 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,17863963 0,20476748 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,17863963 0,20466997 ! neuron fate commitment GO:0048663 48 27 0,000 0,18483579 0,21166821 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 0,000 0,18483579 0,21156752 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,18483579 0,21146691 ! iron ion transport GO:0006826 59 27 0,000 0,18483579 0,21136641 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,18483579 0,21126599 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,18483579 0,21116568 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,18483579 0,21106546 ! autophagy GO:0006914 41 27 0,000 0,18483579 0,21096533 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,18483579 0,2108653 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,18483579 0,21076536 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,18483579 0,21066552 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,18483579 0,21056578 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,19098542 0,21746849 ! circadian rhythm GO:0007623 50 28 0,000 0,19098542 0,21736562 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,19098542 0,21726285 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 59 28 0,000 0,19098542 0,21716017 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,19098542 0,21705759 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,19098542 0,21695511 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,19098542 0,21685272 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,19098542 0,21675043 ! synaptogenesis GO:0007416 42 28 0,000 0,19098542 0,21664824 ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,19098542 0,21654615 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,19098542 0,21644415 ! translational initiation GO:0006413 65 29 0,000 0,19708886 0,22325602 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,19708886 0,22315096 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,19708886 0,223046 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,19708886 0,22294113 ! catechol metabolic process GO:0009712 54 29 0,000 0,19708886 0,22283637 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,19708886 0,2227317 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,19708886 0,22262713 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,19708886 0,22252266 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,19708886 0,22241829 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,19708886 0,22231401 ! cell fate determination GO:0001709 60 29 0,000 0,19708886 0,22220984 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,19708886 0,22210576 ! detection of light stimulus GO:0009583 38 29 0,000 0,19708886 0,22200177 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 0,000 0,19708886 0,22189789 ! regulation of coagulation GO:0050818 46 29 0,000 0,19708886 0,2217941 ! phenol metabolic process GO:0018958 55 30 0,000 0,20314645 0,22850414 ! zinc ion transport GO:0006829 45 30 0,000 0,20314645 0,22839736 ! membrane docking GO:0022406 61 30 0,000 0,20314645 0,22829068 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,20314645 0,22818411 ! regulation of innate immune response GO:0045088 51 30 0,000 0,20314645 0,22807763 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,20314645 0,22797125 ! phospholipid transport GO:0015914 51 30 0,000 0,20314645 0,22786497 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,20314645 0,22775879 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,20314645 0,2276527 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,20314645 0,22754672 ! eye morphogenesis GO:0048592 60 30 0,000 0,20314645 0,22744084 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,20915854 0,234063 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,20915854 0,23395418 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,20915854 0,23384547 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,20915854 0,23373685 GO:0009799|determination of symmetry, ! inner ear morphogenesis GO:0042472 47 31 0,000 0,20915854 0,23362834 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,20915854 0,23351993 GO:0055092|sterol homeostasis, ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,20915854 0,23341162 ! peptide transport GO:0015833 55 31 0,000 0,20915854 0,2333034 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,20915854 0,23319529 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,20915854 0,23308728 ! mesoderm formation GO:0001707 69 31 0,000 0,20915854 0,23297937 ! natural killer cell activation GO:0030101 45 31 0,000 0,20915854 0,23287156 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,20915854 0,23276385 ! negative regulation of transcription regulator activity GO:0090048 58 31 0,000 0,20915854 0,23265624 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,20915854 0,23254873 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,21512547 0,23907246 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,21512547 0,23896208 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,21512547 0,23885181 ! cholesterol transport GO:0030301 56 32 0,000 0,21512547 0,23874164 ! spindle organization GO:0007051 46 32 0,000 0,21512547 0,23863157 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,21512547 0,2385216 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,21512547 0,23841173 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,21512547 0,23830197 ! regulation of protein import into nucleus GO:0042306 63 32 0,000 0,21512547 0,2381923 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,21512547 0,23808274 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,21512547 0,23797328 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,21512547 0,23786391 ! BMP signaling pathway GO:0030509 64 32 0,000 0,21512547 0,23775465 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,21512547 0,23764549 ! gene silencing GO:0016458 65 32 0,000 0,21512547 0,23753643 ! protein targeting to membrane GO:0006612 68 33 0,000 0,22104757 0,24396351 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,22104757 0,24385165 ! ceramide metabolic process GO:0006672 64 33 0,000 0,22104757 0,2437399 ! formation of primary germ layer GO:0001704 72 33 0,000 0,22104757 0,24362824 ! sterol transport GO:0015918 57 33 0,000 0,22104757 0,24351669 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,22104757 0,24340524 ! adult locomotory behavior GO:0008344 59 33 0,000 0,22104757 0,2432939 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,22104757 0,24318265 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,22692519 0,24953474 ! glial cell differentiation GO:0010001 63 34 0,000 0,22692519 0,24942074 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,22692519 0,24930685 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,22692519 0,24919306 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,22692519 0,24907938 ! mismatch repair GO:0006298 46 34 0,000 0,22692519 0,2489658 ! spermatid development GO:0007286 63 34 0,000 0,22692519 0,24885233 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,22692519 0,24873895 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,22692519 0,24862568 ! negative regulation of secretion GO:0051048 63 35 0,000 0,23275865 0,25490091 ! odontogenesis GO:0042476 66 35 0,000 0,23275865 0,25478494 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,23275865 0,25466908 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,23275865 0,25455332 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 59 35 0,000 0,23275865 0,25443767 ! regulation of microtubule-based process GO:0032886 78 35 0,000 0,23275865 0,25432212 ! vesicle localization GO:0051648 64 35 0,000 0,23275865 0,25420668 ! mitotic sister chromatid segregation GO:0000070 57 36 0,000 0,23854828 0,2604116 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,23854828 0,2602935 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,23854828 0,26017551 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,23854828 0,26005762 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,23854828 0,25993984 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,23854828 0,25982217 ! regulation of proteolysis GO:0030162 72 36 0,000 0,23854828 0,2597046 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,23854828 0,25958714 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,23854828 0,25946979 ! aerobic respiration GO:0009060 55 36 0,000 0,23854828 0,25935254 ! androgen receptor signaling pathway GO:0030521 74 36 0,000 0,23854828 0,2592354 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,23854828 0,25911836 ! RNA export from nucleus GO:0006405 56 37 0,000 0,24429442 0,26524024 ! meiosis I GO:0007127 65 37 0,000 0,24429442 0,2651206 ! sister chromatid segregation GO:0000819 58 37 0,000 0,24429442 0,26500107 ! organic anion transport GO:0015711 68 37 0,000 0,24429442 0,26488165 ! tissue remodeling GO:0048771 76 37 0,000 0,24429442 0,26476233 ! negative regulation of DNA binding GO:0043392 68 37 0,000 0,24429442 0,26464312 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,24429442 0,26452402 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,24429442 0,26440503 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,24429442 0,26428614 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 66 37 0,000 0,24429442 0,26416736 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,24999738 0,27021281 GO:0006956|complement activation, ! regulation of neuron projection development GO:0010975 91 38 0,000 0,24999738 0,27009147 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,24999738 0,26997024 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,24999738 0,26984913 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,24999738 0,26972812 ! mRNA catabolic process GO:0006402 71 39 0,000 0,2556575 0,27571131 ! organic ether metabolic process GO:0018904 55 39 0,000 0,2556575 0,27558779 ! ion transmembrane transport GO:0034220 66 39 0,000 0,2556575 0,27546437 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,2556575 0,27534107 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,2556575 0,27521787 ! RNA modification GO:0009451 57 39 0,000 0,2556575 0,27509479 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,2556575 0,27497181 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,26127508 0,28088823 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,26127508 0,28076278 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,26127508 0,28063743 ! feeding behavior GO:0007631 59 40 0,000 0,26127508 0,28051221 ! negative regulation of binding GO:0051100 72 40 0,000 0,26127508 0,28038709 ! maintenance of protein location GO:0045185 91 40 0,000 0,26127508 0,28026208 ! cytokinesis GO:0000910 72 40 0,000 0,26127508 0,28013719 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,26685046 0,28598762 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,26685046 0,28586029 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,26685046 0,28573307 ! gliogenesis GO:0042063 88 41 0,000 0,26685046 0,28560596 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,26685046 0,28547897 ! dorsal/ventral pattern formation GO:0009953 68 41 0,000 0,26685046 0,28535209 ! negative regulation of protein complex disassembly GO:0043242 101 42 0,000 0,27238394 0,29113983 ! regulation of tube size GO:0035150 71 42 0,000 0,27238394 0,29101055 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,27238394 0,29088138 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,27238394 0,29075233 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,27238394 0,2906234 ! regulation of protein secretion GO:0050708 71 42 0,000 0,27238394 0,29049457 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,27238394 0,29036587 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,27787584 0,29608913 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,27787584 0,29595806 ! striated muscle contraction GO:0006941 77 43 0,000 0,27787584 0,29582711 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,27787584 0,29569627 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,28332647 0,30136316 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,28332647 0,30122999 ! biopolymer methylation GO:0043414 84 44 0,000 0,28332647 0,30109694 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,28332647 0,30096401 ! JAK-STAT cascade GO:0007259 71 44 0,000 0,28332647 0,30083119 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,28873613 0,30643985 ! glycolysis GO:0006096 65 45 0,000 0,28873613 0,30630473 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,28873613 0,30616974 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,28873613 0,30603486 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,28873613 0,3059001 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,28873613 0,30576546 ! cell growth GO:0016049 84 45 0,000 0,28873613 0,30563094 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,29410514 0,31117721 ! endosome transport GO:0016197 108 47 0,000 0,2994338 0,31667593 ! vascular process in circulatory system GO:0003018 80 47 0,000 0,2994338 0,31653679 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,2994338 0,31639777 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,2994338 0,31625888 ! JNK cascade GO:0007254 91 47 0,000 0,2994338 0,31612011 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,2994338 0,31598146 ! methylation GO:0032259 90 47 0,000 0,2994338 0,31584293 ! protein homooligomerization GO:0051260 76 47 0,000 0,2994338 0,31570453 ! Notch signaling pathway GO:0007219 96 48 0,000 0,30472241 0,32113978 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,30472241 0,32099918 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,30472241 0,3208587 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,30472241 0,32071834 ! regulation of protein complex disassembly GO:0043244 113 49 0,000 0,30997128 0,32610008 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,30997128 0,32595756 ! regulation of ion transport GO:0043269 77 49 0,000 0,30997128 0,32581515 ! endocrine system development GO:0035270 104 49 0,000 0,30997128 0,32567288 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,30997128 0,32553072 GO:0019724|B cell mediated immunity, ! regulation of cell projection organization GO:0031344 121 50 0,000 0,31518068 0,33085721 ! neuromuscular process GO:0050905 99 50 0,000 0,31518068 0,33071292 ! inner ear development GO:0048839 79 50 0,000 0,31518068 0,33056876 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,31518068 0,33042472 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,31518068 0,3302808 ! embryonic skeletal system development GO:0048706 85 51 0,000 0,32035094 0,33555261 ! excretion GO:0007588 83 51 0,000 0,32035094 0,33540659 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,32035094 0,3352607 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,32035094 0,33511494 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,32035094 0,3349693 ! membrane fusion GO:0006944 110 52 0,000 0,32548233 0,340187 ! amino acid activation GO:0043038 92 52 0,000 0,32548233 0,34003929 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 76 53 0,000 0,33057514 0,34520998 ! RNA catabolic process GO:0006401 93 53 0,000 0,33057514 0,34506021 ! regulation of translational initiation GO:0006446 82 53 0,000 0,33057514 0,34491058 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,33057514 0,34476107 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,33057514 0,34461169 ! negative regulation of cytoskeleton organization GO:0051494 124 54 0,000 0,33562967 0,34972932 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,33562967 0,34957792 ! cell recognition GO:0008037 85 54 0,000 0,33562967 0,34942665 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,33562967 0,34927552 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,33562967 0,34912451 ! glucose catabolic process GO:0006007 82 55 0,000 0,34064621 0,35418962 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,34064621 0,35403662 ! gastrulation GO:0007369 112 55 0,000 0,34064621 0,35388375 ! RNA elongation GO:0006354 79 55 0,000 0,34064621 0,35373102 ! nuclear export GO:0051168 97 55 0,000 0,34064621 0,35357842 ! regulation of actin filament length GO:0030832 105 56 0,000 0,34562503 0,35859156 ! sensory perception of smell GO:0007608 80 56 0,000 0,34562503 0,35843699 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,34562503 0,35828256 ! proton transport GO:0015992 94 56 0,000 0,34562503 0,35812826 ! positive regulation of organelle organization GO:0010638 100 56 0,000 0,34562503 0,35797409 ! hydrogen transport GO:0006818 97 58 0,000 0,35547066 0,36801308 ! adult behavior GO:0030534 99 58 0,000 0,35547066 0,3678548 ! positive regulation of secretion GO:0051047 95 59 0,000 0,36033802 0,37273142 ! regulation of cellular component size GO:0032535 109 59 0,000 0,36033802 0,37257124 ! establishment of organelle localization GO:0051656 109 59 0,000 0,36033802 0,3724112 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,36516879 0,37724178 ! camera-type eye development GO:0043010 116 60 0,000 0,36516879 0,37707988 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,36996324 0,38186682 ! tRNA processing GO:0008033 89 61 0,000 0,36996324 0,38170307 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,36996324 0,38153946 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,37472164 0,38628117 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,37944425 0,39098196 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,37944425 0,39081458 ! steroid hormone receptor signaling pathway GO:0030518 129 63 0,000 0,37944425 0,39064735 ! cell redox homeostasis GO:0045454 102 64 0,000 0,38413135 0,39530369 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,38413135 0,39513469 ! single fertilization GO:0007338 75 64 0,000 0,38413135 0,39496583 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,38878321 0,39957813 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,39340008 0,40415055 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,39340008 0,40397806 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,39798223 0,40850906 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,39798223 0,40833486 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,39798223 0,4081608 ! hexose catabolic process GO:0019320 104 67 0,000 0,39798223 0,40798689 ! adaptive immune response GO:0002250 119 67 0,000 0,39798223 0,40781313 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 0,000 0,39798223 0,40763952 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,40252992 0,41212212 ! negative regulation of ligase activity GO:0051352 112 68 0,000 0,40252992 0,41194682 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 0,000 0,40252992 0,41177167 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,40252992 0,41159668 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,4070434 0,41603501 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,4070434 0,41585835 ! antigen processing and presentation GO:0019882 104 69 0,000 0,4070434 0,41568184 ! amine catabolic process GO:0009310 117 71 0,000 0,41596878 0,42461642 ! regulation of MAPKKK cascade GO:0043408 142 71 0,000 0,41596878 0,42443634 ! regulation of immune effector process GO:0002697 137 71 0,000 0,41596878 0,42425642 ! fertilization GO:0009566 90 73 0,000 0,4247604 0,43303963 ! transition metal ion transport GO:0000041 126 74 0,000 0,42910667 0,43728533 ! neurotransmitter transport GO:0006836 123 74 0,000 0,42910667 0,43710019 ! exocytosis GO:0006887 133 74 0,000 0,42910667 0,43691522 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,42910667 0,43673039 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,42910667 0,43654573 ! eye development GO:0001654 143 74 0,000 0,42910667 0,43636122 ! defense response to bacterium GO:0042742 89 76 0,000 0,43770138 0,44491319 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,43770138 0,4447253 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,43770138 0,44453757 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,44195029 0,44866346 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,44616725 0,45275344 ! negative regulation of organelle organization GO:0010639 161 78 0,000 0,44616725 0,45256256 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,45035248 0,45661528 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,45035248 0,45642294 ! activation of protein kinase activity GO:0032147 147 79 0,000 0,45035248 0,45623076 ! regulation of adenylate cyclase activity GO:0045761 156 80 0,000 0,45450621 0,46024493 ! digestion GO:0007586 112 81 0,000 0,4586287 0,46422408 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,4586287 0,46402887 ! regulation of cAMP biosynthetic process GO:0030817 161 82 0,000 0,46272017 0,46797172 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,46272017 0,46777509 ! regulation of cyclase activity GO:0031279 159 82 0,000 0,46272017 0,46757863 ! regulation of lyase activity GO:0051339 160 83 0,000 0,46678085 0,47148393 ! regulation of cAMP metabolic process GO:0030814 168 84 0,000 0,47081097 0,4753551 ! nucleosome assembly GO:0006334 122 85 0,000 0,47481077 0,47919241 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,47481077 0,47899149 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,47878046 0,48279371 ! chromatin assembly GO:0031497 124 86 0,000 0,47878046 0,48259145 ! alcohol catabolic process GO:0046164 130 86 0,000 0,47878046 0,48238936 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 0,000 0,48272029 0,4861553 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cellular respiration GO:0045333 135 88 0,000 0,48663046 0,48988824 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,48663046 0,48968335 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 0,000 0,49436274 0,49725617 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,49436274 0,49704837 ! sterol metabolic process GO:0016125 152 91 0,000 0,49818529 0,50068246 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,49818529 0,50047341 ! nucleosome organization GO:0034728 138 92 0,000 0,50197907 0,50407414 ! vitamin metabolic process GO:0006766 139 92 0,000 0,50197907 0,50386384 ! regulation of nucleotide metabolic process GO:0006140 182 93 0,000 0,50574429 0,50743151 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,50948117 0,51096777 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,51318992 0,51447289 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,51687075 0,51794711 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,51687075 0,51773148 ! positive regulation of immune response GO:0050778 156 96 0,000 0,51687075 0,51751603 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,52052387 0,52095692 ! hormone metabolic process GO:0042445 157 97 0,000 0,52052387 0,5207403 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,52414949 0,52414949