pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6610-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G2/M transition of mitotic cell cycle GO:0000086 45 25 6,000 9,025E-11 2,205E-07 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 6,000 1,229E-10 1,501E-07 GO:0045936|negative regulation of phosphate metabolic process, ! interphase of mitotic cell cycle GO:0051329 224 98 9,000 3,236E-10 2,635E-07 ! S phase GO:0051320 10 9 4,000 7,891E-10 4,819E-07 GO:0000084|S phase of mitotic cell cycle, ! negative regulation of phosphorylation GO:0042326 52 24 5,000 4,474E-09 2,186E-06 ! glycine biosynthetic process GO:0006545 7 5 3,000 5,562E-09 2,265E-06 ! mitotic sister chromatid segregation GO:0000070 63 36 5,000 6,109E-08 2,132E-05 ! sister chromatid segregation GO:0000819 65 37 5,000 7,256E-08 2,216E-05 ! regulation of lipid kinase activity GO:0043550 17 8 3,000 7,68E-08 2,085E-05 ! negative regulation of protein kinase activity GO:0006469 144 69 6,000 1,631E-07 3,984E-05 ! negative regulation of kinase activity GO:0033673 145 70 6,000 1,803E-07 4,005E-05 ! negative regulation of transferase activity GO:0051348 155 74 6,000 2,654E-07 5,404E-05 ! negative regulation of protein modification process GO:0031400 66 28 4,000 5,625E-07 1,057E-04 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 4,000 6,765E-07 1,18E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 3,000 1,069E-06 1,74E-04 ! serine family amino acid biosynthetic process GO:0009070 19 14 3,000 1,069E-06 1,632E-04 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 2,000 1,93E-06 2,774E-04 ! chromosome segregation GO:0007059 127 67 5,000 2,694E-06 3,656E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 5,000 3,204E-06 4,12E-04 ! glycine metabolic process GO:0006544 30 18 3,000 3,207E-06 3,918E-04 ! cell-substrate junction assembly GO:0007044 56 18 3,000 3,207E-06 3,731E-04 ! nuclear migration GO:0007097 13 6 2,000 3,844E-06 4,268E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 3,844E-06 4,083E-04 GO:0031272|regulation of pseudopodium assembly, ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 5,000 4,834E-06 4,92E-04 ! apoptotic mitochondrial changes GO:0008637 42 20 3,000 5,032E-06 4,917E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 6,452E-06 6,062E-04 ! positive regulation of protein ubiquitination GO:0031398 14 7 2,000 6,697E-06 6,06E-04 ! fibrinolysis GO:0042730 11 7 2,000 6,697E-06 5,843E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 6,697E-06 5,642E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 7,205E-06 5,867E-04 ! pigmentation GO:0043473 103 46 4,000 7,205E-06 5,678E-04 ! positive regulation of phosphorylation GO:0042327 149 81 5,000 8,187E-06 6,25E-04 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 5,000 9,43E-06 6,981E-04 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,067E-05 7,667E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,067E-05 7,447E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 1,067E-05 7,241E-04 ! myeloid leukocyte differentiation GO:0002573 46 25 3,000 1,284E-05 8,479E-04 ! positive regulation of protein modification process GO:0031401 156 90 5,000 1,504E-05 9,668E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 1,511E-05 9,463E-04 ! induction of positive chemotaxis GO:0050930 17 9 2,000 1,594E-05 9,733E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 1,594E-05 9,495E-04 ! macrophage differentiation GO:0030225 15 9 2,000 1,594E-05 9,269E-04 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 2,05E-05 1,165E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 2,267E-05 1,259E-03 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 2,267E-05 1,231E-03 ! chondrocyte differentiation GO:0002062 27 11 2,000 3,103E-05 1,648E-03 ! nitric oxide metabolic process GO:0046209 17 11 2,000 3,103E-05 1,613E-03 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of glucose import GO:0046325 18 11 2,000 3,103E-05 1,58E-03 GO:0010829|negative regulation of glucose transport, ! nucleus localization GO:0051647 22 11 2,000 3,103E-05 1,547E-03 ! cell junction assembly GO:0034329 85 31 3,000 3,108E-05 1,519E-03 ! response to peptide hormone stimulus GO:0043434 129 64 4,000 3,681E-05 1,763E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 4,12E-05 1,936E-03 ! regulation of positive chemotaxis GO:0050926 22 12 2,000 4,12E-05 1,899E-03 GO:0050927|positive regulation of positive chemotaxis, ! regulation of cell projection assembly GO:0060491 33 12 2,000 4,12E-05 1,864E-03 ! focal adhesion formation GO:0048041 37 12 2,000 4,12E-05 1,83E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 4,12E-05 1,797E-03 GO:0042130|negative regulation of T cell proliferation, ! ear development GO:0043583 114 66 4,000 4,274E-05 1,832E-03 ! serine family amino acid metabolic process GO:0009069 56 34 3,000 4,519E-05 1,903E-03 ! negative regulation of cell growth GO:0030308 142 67 4,000 4,597E-05 1,904E-03 ! myeloid cell differentiation GO:0030099 126 67 4,000 4,597E-05 1,872E-03 ! negative regulation of cell size GO:0045792 144 69 4,000 5,299E-05 2,122E-03 ! lung development GO:0030324 165 69 4,000 5,299E-05 2,088E-03 ! regulation of skeletal muscle fiber development GO:0048742 32 13 2,000 5,333E-05 2,068E-03 ! cell junction organization GO:0034330 96 37 3,000 6,348E-05 2,423E-03 ! respiratory tube development GO:0030323 171 72 4,000 6,505E-05 2,445E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 6,758E-05 2,502E-03 ! regulation of protein stability GO:0031647 77 38 3,000 7,062E-05 2,575E-03 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 7,062E-05 2,537E-03 ! respiratory system development GO:0060541 175 74 4,000 7,419E-05 2,627E-03 ! regulation of skeletal muscle tissue development GO:0048641 35 15 2,000 8,412E-05 2,936E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 8,412E-05 2,894E-03 ! dopamine metabolic process GO:0042417 35 15 2,000 8,412E-05 2,854E-03 ! regulation of protein ubiquitination GO:0031396 28 16 2,000 1,031E-04 3,45E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,031E-04 3,403E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! epithelial cell differentiation GO:0030855 83 43 3,000 1,154E-04 3,759E-03 ! filopodium assembly GO:0046847 42 17 2,000 1,246E-04 4,006E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 1,246E-04 3,954E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 1,246E-04 3,904E-03 ! negative regulation of blood coagulation GO:0030195 25 17 2,000 1,246E-04 3,854E-03 ! response to drug GO:0042493 149 83 4,000 1,282E-04 3,914E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 1,381E-04 4,165E-03 ! negative regulation of growth GO:0045926 168 85 4,000 1,435E-04 4,274E-03 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 1,435E-04 4,222E-03 ! negative regulation of protein catabolic process GO:0042177 42 18 2,000 1,489E-04 4,331E-03 ! microspike assembly GO:0030035 46 18 2,000 1,489E-04 4,28E-03 ! cell growth GO:0016049 90 46 3,000 1,505E-04 4,276E-03 ! response to insulin stimulus GO:0032868 98 47 3,000 1,638E-04 4,6E-03 ! amine biosynthetic process GO:0009309 146 88 4,000 1,689E-04 4,69E-03 ! one-carbon metabolic process GO:0006730 167 88 4,000 1,689E-04 4,637E-03 ! memory GO:0007613 34 19 2,000 1,761E-04 4,78E-03 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 2,000 1,761E-04 4,727E-03 ! JAK-STAT cascade GO:0007259 82 48 3,000 1,779E-04 4,724E-03 ! regulation of cell cycle process GO:0010564 161 90 4,000 1,877E-04 4,932E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 1,928E-04 5,011E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 2,063E-04 5,305E-03 ! response to alkaloid GO:0043279 38 20 2,000 2,063E-04 5,249E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 2,063E-04 5,195E-03 ! estrogen receptor signaling pathway GO:0030520 45 20 2,000 2,063E-04 5,142E-03 ! regulation of glucose import GO:0046324 30 20 2,000 2,063E-04 5,09E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 2,063E-04 5,039E-03 ! negative regulation of coagulation GO:0050819 30 20 2,000 2,063E-04 4,989E-03 ! induction of apoptosis by extracellular signals GO:0008624 99 50 3,000 2,086E-04 4,997E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 2,396E-04 5,684E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 2,396E-04 5,629E-03 ! cellular amino acid biosynthetic process GO:0008652 80 52 3,000 2,43E-04 5,655E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 3,000 2,617E-04 6,031E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 2,617E-04 5,975E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA metabolic process GO:0051052 188 97 4,000 2,664E-04 6,026E-03 ! glutamate signaling pathway GO:0007215 48 22 2,000 2,763E-04 6,192E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 2,763E-04 6,136E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 2,763E-04 6,08E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 2,763E-04 6,026E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 2,000 2,763E-04 5,973E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 2,763E-04 5,92E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 2,763E-04 5,869E-03 ! response to cytokine stimulus GO:0034097 69 22 2,000 2,763E-04 5,818E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 2,000 2,763E-04 5,769E-03 ! inner ear receptor cell differentiation GO:0060113 42 22 2,000 2,763E-04 5,72E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 2,794E-04 5,736E-03 ! forebrain development GO:0030900 210 98 4,000 2,794E-04 5,688E-03 ! regulation of chemotaxis GO:0050920 45 23 2,000 3,164E-04 6,387E-03 ! regulation of cell-matrix adhesion GO:0001952 81 23 2,000 3,164E-04 6,335E-03 GO:0010810|regulation of cell-substrate adhesion, ! response to ethanol GO:0045471 47 23 2,000 3,164E-04 6,283E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 3,164E-04 6,233E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 3,337E-04 6,521E-03 GO:0045844|positive regulation of striated muscle development, ! positive regulation of helicase activity GO:0051096 12 5 1,000 3,337E-04 6,469E-03 ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 3,337E-04 6,418E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 3,337E-04 6,368E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 3,337E-04 6,319E-03 ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 1,000 3,337E-04 6,27E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 3,337E-04 6,222E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 3,337E-04 6,175E-03 ! valine metabolic process GO:0006573 12 5 1,000 3,337E-04 6,129E-03 ! muscle cell migration GO:0014812 8 5 1,000 3,337E-04 6,083E-03 ! response to tumor necrosis factor GO:0034612 10 5 1,000 3,337E-04 6,038E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 3,337E-04 5,994E-03 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 1,000 3,337E-04 5,95E-03 ! G2/M transition checkpoint GO:0031576 8 5 1,000 3,337E-04 5,907E-03 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 3,337E-04 5,864E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 3,337E-04 5,822E-03 ! tetrahydrofolate metabolic process GO:0046653 7 5 1,000 3,337E-04 5,781E-03 ! decidualization GO:0046697 11 5 1,000 3,337E-04 5,74E-03 ! B cell homeostasis GO:0001782 13 5 1,000 3,337E-04 5,7E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 3,337E-04 5,661E-03 ! regulation of sensory perception GO:0051931 8 5 1,000 3,337E-04 5,622E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 3,337E-04 5,583E-03 ! receptor biosynthetic process GO:0032800 7 5 1,000 3,337E-04 5,545E-03 ! stem cell division GO:0017145 11 5 1,000 3,337E-04 5,508E-03 GO:0048103|somatic stem cell division, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 3,6E-04 5,903E-03 ! mechanoreceptor differentiation GO:0042490 48 24 2,000 3,6E-04 5,863E-03 ! negative regulation of catabolic process GO:0009895 52 24 2,000 3,6E-04 5,824E-03 ! establishment of organelle localization GO:0051656 122 59 3,000 3,958E-04 6,361E-03 ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 4,073E-04 6,504E-03 ! receptor metabolic process GO:0043112 53 25 2,000 4,073E-04 6,462E-03 ! regulation of behavior GO:0050795 48 25 2,000 4,073E-04 6,42E-03 ! multicellular organismal response to stress GO:0033555 61 26 2,000 4,585E-04 7,18E-03 ! regulation of blood coagulation GO:0030193 46 26 2,000 4,585E-04 7,134E-03 ! response to interferon-gamma GO:0034341 16 6 1,000 4,986E-04 7,709E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 4,986E-04 7,66E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 4,986E-04 7,612E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 4,986E-04 7,565E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 4,986E-04 7,518E-03 GO:0051653|spindle localization, ! neural nucleus development GO:0048857 19 6 1,000 4,986E-04 7,472E-03 ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 4,986E-04 7,427E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 4,986E-04 7,382E-03 ! neural tube patterning GO:0021532 8 6 1,000 4,986E-04 7,337E-03 ! protein deubiquitination GO:0016579 16 6 1,000 4,986E-04 7,293E-03 ! maternal placenta development GO:0001893 12 6 1,000 4,986E-04 7,25E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 4,986E-04 7,207E-03 ! regulation of mitosis GO:0007088 112 63 3,000 5,087E-04 7,31E-03 GO:0051783|regulation of nuclear division, ! positive regulation of cell projection organization GO:0031346 66 27 2,000 5,136E-04 7,338E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 5,136E-04 7,295E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 5,136E-04 7,253E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 5,136E-04 7,211E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 5,402E-04 7,541E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 5,728E-04 7,95E-03 ! dendrite development GO:0016358 67 28 2,000 5,728E-04 7,906E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 6,072E-04 8,333E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 6,072E-04 8,287E-03 ! catechol metabolic process GO:0009712 55 29 2,000 6,361E-04 8,634E-03 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of helicase activity GO:0051095 16 7 1,000 6,953E-04 9,385E-03 ! sleep GO:0030431 16 7 1,000 6,953E-04 9,333E-03 ! prostate gland development GO:0030850 14 7 1,000 6,953E-04 9,282E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 6,953E-04 9,232E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 6,953E-04 9,182E-03 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 6,953E-04 9,132E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 6,953E-04 9,084E-03 ! lipoprotein transport GO:0042953 14 7 1,000 6,953E-04 9,035E-03 ! organ growth GO:0035265 15 7 1,000 6,953E-04 8,988E-03 ! negative regulation of DNA recombination GO:0045910 16 7 1,000 6,953E-04 8,94E-03 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 6,953E-04 8,893E-03 ! monocyte differentiation GO:0030224 16 7 1,000 6,953E-04 8,847E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 6,953E-04 8,801E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 6,953E-04 8,756E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 6,953E-04 8,711E-03 ! peptidyl-threonine modification GO:0018210 26 7 1,000 6,953E-04 8,667E-03 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 1,000 6,953E-04 8,623E-03 ! dopamine biosynthetic process GO:0042416 18 7 1,000 6,953E-04 8,579E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 6,953E-04 8,536E-03 ! protein modification by small protein removal GO:0070646 19 7 1,000 6,953E-04 8,493E-03 ! phenol metabolic process GO:0018958 56 30 2,000 7,038E-04 8,554E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 7,038E-04 8,512E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 2,000 7,038E-04 8,47E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 7,038E-04 8,428E-03 GO:0043433|negative regulation of transcription factor activity, ! regulation of B cell activation GO:0050864 55 30 2,000 7,038E-04 8,387E-03 ! regulation of coagulation GO:0050818 52 30 2,000 7,038E-04 8,346E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 7,759E-04 9,157E-03 ! cell cycle checkpoint GO:0000075 145 71 3,000 8,003E-04 9,399E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 8,003E-04 9,354E-03 ! actin filament organization GO:0007015 167 72 3,000 8,435E-04 9,813E-03 ! hindbrain development GO:0030902 65 32 2,000 8,525E-04 9,87E-03 ! succinate metabolic process GO:0006105 17 8 1,000 9,235E-04 0,0106423 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 9,235E-04 0,01059233 ! pigment granule organization GO:0048753 17 8 1,000 9,235E-04 0,01054284 ! L-phenylalanine metabolic process GO:0006558 12 8 1,000 9,235E-04 0,0104938 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 1,000 9,235E-04 0,01044522 ! regulation of pigmentation during development GO:0048070 25 8 1,000 9,235E-04 0,01039708 ! melanin metabolic process GO:0006582 17 8 1,000 9,235E-04 0,01034939 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 1,000 9,235E-04 0,01030213 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 9,235E-04 0,0102553 ! response to UV-B GO:0010224 17 8 1,000 9,235E-04 0,0102089 ! trophectodermal cell differentiation GO:0001829 13 8 1,000 9,235E-04 0,01016291 ! leukocyte chemotaxis GO:0030595 55 33 2,000 9,337E-04 0,01022899 GO:0060326|cell chemotaxis, ! organelle localization GO:0051640 155 74 3,000 9,349E-04 0,01019616 ! regulation of transcription factor activity GO:0051090 137 75 3,000 9,831E-04 0,01067433 GO:0090046|regulation of transcription regulator activity, ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 1,02E-03 0,0110227 ! learning or memory GO:0007611 161 76 3,000 1,033E-03 0,01111768 ! regulation of synaptic plasticity GO:0048167 78 35 2,000 1,111E-03 0,01189931 ! regulation of striated muscle tissue development GO:0016202 81 35 2,000 1,111E-03 0,01184735 ! placenta development GO:0001890 53 35 2,000 1,111E-03 0,01179584 ! microtubule bundle formation GO:0001578 22 9 1,000 1,183E-03 0,01250936 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,183E-03 0,01245544 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 1,000 1,183E-03 0,01240199 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! T cell selection GO:0045058 27 9 1,000 1,183E-03 0,01234899 ! receptor clustering GO:0043113 20 9 1,000 1,183E-03 0,01229644 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 1,183E-03 0,01224433 ! response to amine stimulus GO:0014075 13 9 1,000 1,183E-03 0,01219267 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,183E-03 0,01214144 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 1,183E-03 0,01209064 ! neuromuscular process controlling posture GO:0050884 15 9 1,000 1,183E-03 0,01204026 ! regulation of synaptogenesis GO:0051963 15 9 1,000 1,183E-03 0,0119903 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,183E-03 0,01194076 ! regulation of synaptic transmission GO:0050804 159 79 3,000 1,194E-03 0,01199885 ! regulation of muscle development GO:0048634 82 36 2,000 1,206E-03 0,01207808 ! negative regulation of DNA binding GO:0043392 67 36 2,000 1,206E-03 0,01202879 ! negative regulation of cell activation GO:0050866 69 37 2,000 1,307E-03 0,01298132 ! response to hypoxia GO:0001666 178 81 3,000 1,31E-03 0,01295372 ! response to oxygen levels GO:0070482 183 83 3,000 1,434E-03 0,01412168 ! regulation of developmental growth GO:0048638 16 10 1,000 1,473E-03 0,01445074 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,473E-03 0,01439294 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 1,000 1,473E-03 0,0143356 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 1,473E-03 0,01427871 ! GTP metabolic process GO:0046039 11 10 1,000 1,473E-03 0,01422227 ! phosphagen metabolic process GO:0006599 17 10 1,000 1,473E-03 0,01416628 GO:0006600|creatine metabolic process, ! B cell proliferation GO:0042100 19 10 1,000 1,473E-03 0,01411072 ! epithelial cell development GO:0002064 21 10 1,000 1,473E-03 0,0140556 ! motor axon guidance GO:0008045 22 10 1,000 1,473E-03 0,01400091 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,473E-03 0,01394665 ! regulation of fat cell differentiation GO:0045598 18 10 1,000 1,473E-03 0,0138928 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 1,000 1,473E-03 0,01383936 ! induction of an organ GO:0001759 17 10 1,000 1,473E-03 0,01378634 ! midbrain development GO:0030901 14 10 1,000 1,473E-03 0,01373372 ! blastocyst formation GO:0001825 18 10 1,000 1,473E-03 0,0136815 ! response to nicotine GO:0035094 20 10 1,000 1,473E-03 0,01362968 ! negative regulation of binding GO:0051100 71 39 2,000 1,524E-03 0,01405314 ! carbohydrate homeostasis GO:0033500 59 39 2,000 1,524E-03 0,01400031 GO:0042593|glucose homeostasis, ! negative regulation of transport GO:0051051 164 85 3,000 1,565E-03 0,01432279 ! regulation of transmission of nerve impulse GO:0051969 167 85 3,000 1,565E-03 0,01426935 ! learning GO:0007612 82 40 2,000 1,641E-03 0,01490287 ! nucleus organization GO:0006997 73 40 2,000 1,641E-03 0,01484768 ! mitochondrion organization GO:0007005 159 87 3,000 1,705E-03 0,01537356 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 1,763E-03 0,0158343 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 1,763E-03 0,0157763 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,793E-03 0,01598903 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 1,793E-03 0,01593089 ! response to pain GO:0048265 27 11 1,000 1,793E-03 0,01587317 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,793E-03 0,01581586 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,793E-03 0,01575897 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,793E-03 0,01570249 ! behavioral fear response GO:0001662 27 11 1,000 1,793E-03 0,01564641 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 1,793E-03 0,01559073 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,793E-03 0,01553544 ! purine ribonucleotide catabolic process GO:0009154 17 11 1,000 1,793E-03 0,01548054 ! DNA methylation GO:0006306 19 11 1,000 1,793E-03 0,01542604 GO:0006305|DNA alkylation, ! thymus development GO:0048538 29 11 1,000 1,793E-03 0,01537191 ! oocyte development GO:0048599 20 11 1,000 1,793E-03 0,01531816 ! regulation of DNA binding GO:0051101 167 89 3,000 1,854E-03 0,01578037 ! regulation of neurological system process GO:0031644 175 89 3,000 1,854E-03 0,01572558 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,89E-03 0,01598087 ! regulation of T cell differentiation GO:0045580 78 42 2,000 1,89E-03 0,01592576 ! cytokinesis GO:0000910 84 42 2,000 1,89E-03 0,01587103 ! gland development GO:0048732 220 91 3,000 2,011E-03 0,01682537 ! development of primary male sexual characteristics GO:0046546 80 43 2,000 2,024E-03 0,01687273 ! regulation of T cell proliferation GO:0042129 80 43 2,000 2,024E-03 0,01681534 ! neuron migration GO:0001764 85 43 2,000 2,024E-03 0,01675834 ! regulation of cell adhesion GO:0030155 241 92 3,000 2,093E-03 0,01727438 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 2,144E-03 0,01763321 ! hippocampus development GO:0021766 29 12 1,000 2,144E-03 0,01757403 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 2,144E-03 0,01751526 ! entry into host cell GO:0030260 34 12 1,000 2,144E-03 0,01745687 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 2,144E-03 0,01739888 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,144E-03 0,01734127 ! T cell homeostasis GO:0043029 28 12 1,000 2,144E-03 0,01728403 ! oocyte differentiation GO:0009994 21 12 1,000 2,144E-03 0,01722718 ! developmental induction GO:0031128 22 12 1,000 2,144E-03 0,0171707 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 1,000 2,144E-03 0,01711458 ! regulation of synapse organization GO:0050807 18 12 1,000 2,144E-03 0,01705883 ! response to reactive oxygen species GO:0000302 75 44 2,000 2,162E-03 0,01715212 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 2,162E-03 0,01709661 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 2,177E-03 0,01715803 ! regulation of membrane potential GO:0042391 179 94 3,000 2,264E-03 0,01778265 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 2,307E-03 0,01806444 ! negative regulation of multicellular organismal process GO:0051241 174 95 3,000 2,353E-03 0,01836274 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 2,457E-03 0,01911995 ! leukocyte migration GO:0050900 75 46 2,000 2,457E-03 0,01905925 ! positive regulation of protein transport GO:0051222 80 46 2,000 2,457E-03 0,01899893 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 2,524E-03 0,01944974 GO:0000725|recombinational repair, ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 2,524E-03 0,01938857 ! exocrine system development GO:0035272 34 13 1,000 2,524E-03 0,01932779 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,524E-03 0,0192674 ! gland morphogenesis GO:0022612 31 13 1,000 2,524E-03 0,01920737 ! aromatic amino acid family catabolic process GO:0009074 20 13 1,000 2,524E-03 0,01914772 ! spleen development GO:0048536 24 13 1,000 2,524E-03 0,01908844 ! digestive tract morphogenesis GO:0048546 31 13 1,000 2,524E-03 0,01902953 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 2,524E-03 0,01897097 ! regulation of synapse structure and activity GO:0050803 19 13 1,000 2,524E-03 0,01891278 ! folic acid and derivative biosynthetic process GO:0009396 25 13 1,000 2,524E-03 0,01885494 ! ribonucleotide catabolic process GO:0009261 21 13 1,000 2,524E-03 0,01879746 ! indolalkylamine metabolic process GO:0006586 19 13 1,000 2,524E-03 0,01874032 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 2,524E-03 0,01868354 ! nucleoside triphosphate catabolic process GO:0009143 22 13 1,000 2,524E-03 0,01862709 ! regulation of protein localization GO:0032880 188 97 3,000 2,538E-03 0,01867251 ! positive regulation of defense response GO:0031349 88 48 2,000 2,776E-03 0,02036776 ! cellular component disassembly GO:0022411 89 48 2,000 2,776E-03 0,02030678 ! male sex differentiation GO:0046661 93 48 2,000 2,776E-03 0,02024616 ! regulation of inflammatory response GO:0050727 84 48 2,000 2,776E-03 0,0201859 ! hair follicle morphogenesis GO:0031069 27 14 1,000 2,933E-03 0,02126303 ! fear response GO:0042596 34 14 1,000 2,933E-03 0,02120013 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 2,933E-03 0,02113759 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 37 14 1,000 2,933E-03 0,02107542 ! response to gamma radiation GO:0010332 30 14 1,000 2,933E-03 0,02101362 ! catecholamine biosynthetic process GO:0042423 30 14 1,000 2,933E-03 0,02095217 ! male genitalia development GO:0030539 26 14 1,000 2,933E-03 0,02089109 ! regulation of lymphocyte differentiation GO:0045619 92 49 2,000 2,945E-03 0,02091302 ! activation of caspase activity GO:0006919 95 50 2,000 3,119E-03 0,0220891 ! regulation of cell projection organization GO:0031344 135 51 2,000 3,3E-03 0,02330239 ! viral infectious cycle GO:0019058 104 51 2,000 3,3E-03 0,02323524 ! negative regulation of immune system process GO:0002683 101 51 2,000 3,3E-03 0,02316847 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 3,371E-03 0,0236001 ! pteridine and derivative biosynthetic process GO:0042559 20 15 1,000 3,371E-03 0,02353267 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3,371E-03 0,02346562 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 1,000 3,371E-03 0,02339896 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 3,371E-03 0,02333267 ! regulation of exocytosis GO:0017157 26 15 1,000 3,371E-03 0,02326676 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 3,371E-03 0,02320122 ! lymphocyte homeostasis GO:0002260 33 15 1,000 3,371E-03 0,02313605 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 3,487E-03 0,02386528 ! positive regulation of growth GO:0045927 96 53 2,000 3,681E-03 0,02511939 ! inner ear development GO:0048839 89 53 2,000 3,681E-03 0,02504942 ! cartilage development GO:0051216 99 53 2,000 3,681E-03 0,02497984 ! heterophilic cell adhesion GO:0007157 43 16 1,000 3,838E-03 0,02597532 ! startle response GO:0001964 28 16 1,000 3,838E-03 0,02590356 ! regulation of dephosphorylation GO:0035303 43 16 1,000 3,838E-03 0,0258322 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 3,838E-03 0,02576124 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 3,838E-03 0,02569066 ! regulation of angiogenesis GO:0045765 125 54 2,000 3,881E-03 0,02590519 ! neuromuscular process GO:0050905 107 54 2,000 3,881E-03 0,0258346 ! regulation of muscle contraction GO:0006937 94 54 2,000 3,881E-03 0,0257644 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 4,087E-03 0,02706159 ! cell maturation GO:0048469 107 55 2,000 4,087E-03 0,02698845 ! response to UV GO:0009411 120 55 2,000 4,087E-03 0,02691571 ! regulation of protein catabolic process GO:0042176 126 56 2,000 4,301E-03 0,02824243 ! regulation of DNA replication GO:0006275 105 56 2,000 4,301E-03 0,02816671 ! metencephalon development GO:0022037 32 17 1,000 4,334E-03 0,02830687 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 4,334E-03 0,02823139 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 4,334E-03 0,0281563 ! signal complex assembly GO:0007172 47 17 1,000 4,334E-03 0,02808162 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 4,334E-03 0,02800733 ! regulation of survival gene product expression GO:0045884 38 17 1,000 4,334E-03 0,02793343 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 4,334E-03 0,02785992 GO:0031114|regulation of microtubule depolymerization, ! regulation of protein binding GO:0043393 33 17 1,000 4,334E-03 0,0277868 ! genitalia development GO:0048806 32 17 1,000 4,334E-03 0,02771406 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 4,334E-03 0,0276417 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 4,334E-03 0,02756971 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 4,52E-03 0,02868263 ! positive regulation of caspase activity GO:0043280 108 57 2,000 4,52E-03 0,02860832 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 2,000 4,52E-03 0,0285344 ! positive regulation of cell migration GO:0030335 137 58 2,000 4,747E-03 0,02988597 ! aging GO:0007568 112 58 2,000 4,747E-03 0,02980915 ! limbic system development GO:0021761 40 18 1,000 4,857E-03 0,03042215 ! regulation of viral genome replication GO:0045069 30 18 1,000 4,857E-03 0,03034434 ! epidermis morphogenesis GO:0048730 43 18 1,000 4,857E-03 0,03026693 ! long-chain fatty acid transport GO:0015909 32 18 1,000 4,857E-03 0,03018992 ! aromatic compound biosynthetic process GO:0019438 26 18 1,000 4,857E-03 0,0301133 ! defense response to virus GO:0051607 43 18 1,000 4,857E-03 0,03003706 ! positive regulation of synaptic transmission GO:0050806 35 18 1,000 4,857E-03 0,02996121 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 4,857E-03 0,02988574 ! lipid modification GO:0030258 112 60 2,000 5,219E-03 0,03203807 ! DNA catabolic process GO:0006308 94 60 2,000 5,219E-03 0,03195777 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 5,407E-03 0,03302467 ! regulation of neuronal synaptic plasticity GO:0048168 51 19 1,000 5,407E-03 0,03294231 ! regulation of postsynaptic membrane potential GO:0060078 38 19 1,000 5,407E-03 0,03286037 ! cerebral cortex development GO:0021987 40 19 1,000 5,407E-03 0,03277883 ! pigmentation during development GO:0048066 42 19 1,000 5,407E-03 0,03269769 ! neuromuscular junction development GO:0007528 43 19 1,000 5,407E-03 0,03261696 ! response to lipopolysaccharide GO:0032496 34 19 1,000 5,407E-03 0,03253662 ! visual learning GO:0008542 38 19 1,000 5,407E-03 0,03245668 ! cellular pigmentation GO:0033059 37 19 1,000 5,407E-03 0,03237713 ! folic acid and derivative metabolic process GO:0006760 39 19 1,000 5,407E-03 0,03229796 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 1,000 5,407E-03 0,03221919 ! proximal/distal pattern formation GO:0009954 33 19 1,000 5,407E-03 0,0321408 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 1,000 5,407E-03 0,03206279 ! regulation of heart contraction GO:0008016 123 61 2,000 5,466E-03 0,03233381 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 5,466E-03 0,03225571 ! viral reproductive process GO:0022415 132 62 2,000 5,72E-03 0,03367091 ! regulation of homeostatic process GO:0032844 148 62 2,000 5,72E-03 0,03358997 ! regulation of protein complex assembly GO:0043254 132 63 2,000 5,98E-03 0,03503588 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 5,985E-03 0,03498 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 5,985E-03 0,03489651 ! protein amino acid acetylation GO:0006473 41 20 1,000 5,985E-03 0,03481342 ! forelimb morphogenesis GO:0035136 35 20 1,000 5,985E-03 0,03473073 ! actin filament bundle formation GO:0051017 47 20 1,000 5,985E-03 0,03464843 ! fatty acid beta-oxidation GO:0006635 36 20 1,000 5,985E-03 0,03456652 ! positive regulation of neurological system process GO:0031646 39 20 1,000 5,985E-03 0,034485 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 5,985E-03 0,03440385 ! purine nucleotide catabolic process GO:0006195 32 20 1,000 5,985E-03 0,03432309 ! aromatic compound catabolic process GO:0019439 31 20 1,000 5,985E-03 0,03424271 ! multicellular organism reproduction GO:0032504 123 65 2,000 6,522E-03 0,03722994 GO:0048609|reproductive process in a multicellular organism, ! positive regulation of cell motion GO:0051272 157 65 2,000 6,522E-03 0,03714315 ! lipid phosphorylation GO:0046834 43 21 1,000 6,59E-03 0,03743985 ! ovarian follicle development GO:0001541 39 21 1,000 6,59E-03 0,03735298 ! neurotransmitter metabolic process GO:0042133 39 21 1,000 6,59E-03 0,03726652 ! prostaglandin metabolic process GO:0006693 43 21 1,000 6,59E-03 0,03718045 GO:0006692|prostanoid metabolic process, ! collagen catabolic process GO:0030574 29 21 1,000 6,59E-03 0,03709478 ! pteridine and derivative metabolic process GO:0042558 32 22 1,000 7,221E-03 0,0405553 ! ureteric bud development GO:0001657 50 22 1,000 7,221E-03 0,04046229 ! cell aging GO:0007569 48 22 1,000 7,221E-03 0,04036969 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 7,221E-03 0,04027753 ! renal system process GO:0003014 42 22 1,000 7,221E-03 0,04018578 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 7,221E-03 0,04009445 ! positive regulation of B cell activation GO:0050871 42 22 1,000 7,221E-03 0,04000353 ! somatic diversification of immunoglobulins GO:0016445 55 22 1,000 7,221E-03 0,03991302 ! gut development GO:0048565 44 22 1,000 7,221E-03 0,03982293 ! protein stabilization GO:0050821 41 22 1,000 7,221E-03 0,03973324 ! viral reproduction GO:0016032 142 68 2,000 7,389E-03 0,04056455 ! cell projection assembly GO:0030031 138 68 2,000 7,389E-03 0,0404736 ! urogenital system development GO:0001655 149 69 2,000 7,692E-03 0,04204016 ! homeostasis of number of cells GO:0048872 131 69 2,000 7,692E-03 0,04194632 ! developmental maturation GO:0021700 128 69 2,000 7,692E-03 0,04185289 ! positive regulation of DNA replication GO:0045740 44 23 1,000 7,879E-03 0,04277356 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 7,879E-03 0,04267871 ! gluconeogenesis GO:0006094 38 23 1,000 7,879E-03 0,04258429 ! glycerol metabolic process GO:0006071 40 23 1,000 7,879E-03 0,04249029 ! viral genome replication GO:0019079 44 23 1,000 7,879E-03 0,0423967 ! regeneration GO:0031099 42 23 1,000 7,879E-03 0,04230352 ! visual behavior GO:0007632 46 23 1,000 7,879E-03 0,04221075 ! regulation of DNA recombination GO:0000018 51 23 1,000 7,879E-03 0,04211838 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 7,879E-03 0,04202642 ! DNA modification GO:0006304 36 23 1,000 7,879E-03 0,04193486 ! fatty acid transport GO:0015908 47 23 1,000 7,879E-03 0,0418437 ! response to molecule of bacterial origin GO:0002237 40 23 1,000 7,879E-03 0,04175293 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 8,562E-03 0,045277 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 1,000 8,562E-03 0,04517921 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 1,000 8,562E-03 0,04508184 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 8,562E-03 0,04498489 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 8,562E-03 0,04488836 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 8,562E-03 0,04479224 ! regulation of viral reproduction GO:0050792 41 24 1,000 8,562E-03 0,04469653 ! membrane depolarization GO:0051899 45 24 1,000 8,562E-03 0,04460123 ! pallium development GO:0021543 56 24 1,000 8,562E-03 0,04450633 ! oogenesis GO:0048477 44 24 1,000 8,562E-03 0,04441184 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 8,562E-03 0,04431774 ! aromatic amino acid family metabolic process GO:0009072 37 24 1,000 8,562E-03 0,04422405 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 8,562E-03 0,04413075 ! leukocyte adhesion GO:0007159 55 25 1,000 9,272E-03 0,04768505 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 9,272E-03 0,04758487 ! vasculogenesis GO:0001570 49 25 1,000 9,272E-03 0,04748511 ! interaction with host GO:0051701 66 25 1,000 9,272E-03 0,04738577 ! lymphocyte proliferation GO:0046651 55 25 1,000 9,272E-03 0,04728684 ! immunoglobulin production GO:0002377 62 25 1,000 9,272E-03 0,04718833 GO:0002440|production of molecular mediator of immune response, ! leukocyte homeostasis GO:0001776 50 25 1,000 9,272E-03 0,04709022 ! regulation of caspase activity GO:0043281 136 74 2,000 9,318E-03 0,04722666 ! reproductive structure development GO:0048608 131 75 2,000 9,665E-03 0,0488854 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 9,665E-03 0,04878439 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 0,01000597 0,05040121 ! myelination GO:0042552 50 26 1,000 0,01000597 0,05029751 ! initiation of viral infection GO:0019059 60 26 1,000 0,01000597 0,05019423 ! pyruvate metabolic process GO:0006090 43 26 1,000 0,01000597 0,05009137 ! molting cycle process GO:0022404 52 26 1,000 0,01000597 0,04998893 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 0,01000597 0,04988691 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 0,01000597 0,04978531 ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,01000597 0,04968412 GO:0045840|positive regulation of mitosis, ! somatic diversification of immune receptors GO:0002200 63 26 1,000 0,01000597 0,04958334 ! blastocyst development GO:0001824 50 26 1,000 0,01000597 0,04948297 ! alditol metabolic process GO:0019400 44 26 1,000 0,01000597 0,04938301 ! cell-matrix adhesion GO:0007160 181 76 2,000 0,01001976 0,04935136 ! regulation of blood pressure GO:0008217 134 76 2,000 0,01001976 0,04925206 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 0,01038199 0,05093013 ! regulation of catabolic process GO:0009894 173 77 2,000 0,01038199 0,05082806 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 0,01076536 0,05259955 ! mitochondrial membrane organization GO:0007006 60 27 1,000 0,01076536 0,05249456 ! multicellular organismal catabolic process GO:0044243 38 27 1,000 0,01076536 0,05238999 ! response to toxin GO:0009636 49 27 1,000 0,01076536 0,05228584 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01076536 0,0521821 ! leukocyte proliferation GO:0070661 59 27 1,000 0,01076536 0,05207877 GO:0032943|mononuclear cell proliferation, ! blood coagulation GO:0007596 151 79 2,000 0,01112904 0,05373172 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 2,000 0,01112904 0,05362574 ! development of primary sexual characteristics GO:0045137 143 80 2,000 0,01151391 0,05537105 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01151391 0,05526226 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 0,01154941 0,05532392 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01154941 0,05521565 ! fat cell differentiation GO:0045444 57 28 1,000 0,01154941 0,05510781 ! group transfer coenzyme metabolic process GO:0006752 53 28 1,000 0,01154941 0,05500039 ! lipid oxidation GO:0034440 48 28 1,000 0,01154941 0,05489338 GO:0019395|fatty acid oxidation, ! meiosis GO:0007126 143 81 2,000 0,01190638 0,05648019 GO:0051327|M phase of meiotic cell cycle, ! regulation of peptidase activity GO:0052547 150 82 2,000 0,01230648 0,05826496 ! cell-substrate adhesion GO:0031589 189 82 2,000 0,01230648 0,05815226 ! meiotic cell cycle GO:0051321 144 82 2,000 0,01230648 0,05804 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,0123578 0,05816974 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,0123578 0,05805788 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,0123578 0,05794644 ! somitogenesis GO:0001756 52 29 1,000 0,0123578 0,05783544 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,0123578 0,05772485 ! response to nutrient GO:0007584 135 84 2,000 0,01312961 0,06121304 ! regulation of ligase activity GO:0051340 147 84 2,000 0,01312961 0,06109645 ! tissue homeostasis GO:0001894 50 30 1,000 0,01319023 0,06126183 GO:0048871|multicellular organismal homeostasis, ! hemostasis GO:0007599 165 85 2,000 0,01355269 0,06282585 ! ovulation cycle process GO:0022602 55 31 1,000 0,01404639 0,06499115 ! male gonad development GO:0008584 56 31 1,000 0,01404639 0,06486829 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01404639 0,0647459 ! erythrocyte differentiation GO:0030218 62 31 1,000 0,01404639 0,06462397 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 0,01404639 0,06450249 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01404639 0,06438148 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01404639 0,06426091 GO:0008366|axon ensheathment, ! fatty acid catabolic process GO:0009062 54 31 1,000 0,01404639 0,0641408 ! response to heat GO:0009408 54 31 1,000 0,01404639 0,06402113 ! regulation of protein transport GO:0051223 165 87 2,000 0,01442198 0,0656106 GO:0070201|regulation of establishment of protein localization, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,01492598 0,06777728 ! collagen metabolic process GO:0032963 49 32 1,000 0,01492598 0,06765153 ! spindle organization GO:0007051 50 32 1,000 0,01492598 0,06752625 ! metanephros development GO:0001656 81 32 1,000 0,01492598 0,06740143 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,01492598 0,06727708 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,01492598 0,06715318 ! hexose biosynthetic process GO:0019319 53 32 1,000 0,01492598 0,06702973 ! ovulation cycle GO:0042698 57 32 1,000 0,01492598 0,06690674 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01492598 0,0667842 ! tube morphogenesis GO:0035239 194 89 2,000 0,01532221 0,06843172 ! response to ionizing radiation GO:0010212 74 33 1,000 0,01582871 0,07056485 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,01582871 0,07043632 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01675427 0,07441943 ! post-embryonic development GO:0009791 76 34 1,000 0,01675427 0,07428437 ! cell fate specification GO:0001708 56 34 1,000 0,01675427 0,0741498 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01675427 0,07401571 ! DNA damage checkpoint GO:0000077 78 35 1,000 0,01770238 0,07806301 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,01770238 0,07792236 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 0,01770238 0,07778221 ! telencephalon development GO:0021537 81 35 1,000 0,01770238 0,07764257 ! biogenic amine biosynthetic process GO:0042401 65 35 1,000 0,01770238 0,07750342 ! female pregnancy GO:0007565 166 94 2,000 0,01770886 0,0773931 ! regulation of defense response GO:0031347 171 95 2,000 0,0182096 0,0794394 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,01867273 0,0813146 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01867273 0,08116991 ! monosaccharide biosynthetic process GO:0046364 57 36 1,000 0,01867273 0,08102573 ! sex differentiation GO:0007548 171 96 2,000 0,01871817 0,0810789 ! regulation of T cell activation GO:0050863 175 96 2,000 0,01871817 0,0809354 ! biogenic amine metabolic process GO:0006576 162 97 2,000 0,01923458 0,08302133 ! transcription initiation GO:0006352 171 97 2,000 0,01923458 0,08287491 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,01966505 0,0845805 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01966505 0,08443185 ! odontogenesis GO:0042476 74 37 1,000 0,01966505 0,08428372 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,01966505 0,08413612 ! female gonad development GO:0008585 71 37 1,000 0,01966505 0,08398902 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 0,01966505 0,08384245 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,01966505 0,08369638 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,02067905 0,08785897 ! meiosis I GO:0007127 74 38 1,000 0,02067905 0,08770644 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,02067905 0,08755444 ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,02067905 0,08740296 ! glycogen metabolic process GO:0005977 63 38 1,000 0,02067905 0,087252 ! pigment metabolic process GO:0042440 87 38 1,000 0,02067905 0,08710157 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,02083082 0,08758985 GO:0060538|skeletal muscle organ development, ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,02171443 0,09114839 ! nucleotide catabolic process GO:0009166 70 39 1,000 0,02171443 0,09099204 ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,02171443 0,09083623 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,02171443 0,09068096 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 0,02171443 0,09052621 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 93 40 1,000 0,02277093 0,09476897 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,02277093 0,0946078 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 1,000 0,02277093 0,09444717 ! mismatch repair GO:0006298 58 40 1,000 0,02277093 0,0942871 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,02277093 0,09412756 ! Rho protein signal transduction GO:0007266 88 40 1,000 0,02277093 0,09396856 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 1,000 0,02384826 0,09824841 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,02384826 0,09808301 ! mesenchymal cell development GO:0014031 94 41 1,000 0,02384826 0,09791816 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 95 41 1,000 0,02384826 0,09775387 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,02494615 0,10208283 ! ear morphogenesis GO:0042471 64 42 1,000 0,02494615 0,10191212 ! alcohol biosynthetic process GO:0046165 65 42 1,000 0,02494615 0,10174198 ! T cell differentiation GO:0030217 93 42 1,000 0,02494615 0,10157241 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,02494615 0,10140341 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02606432 0,10577266 GO:0090047|positive regulation of transcription regulator activity, ! glucose transport GO:0015758 66 43 1,000 0,02606432 0,10559725 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,02606432 0,10542242 ! monocarboxylic acid transport GO:0015718 93 43 1,000 0,02606432 0,10524817 ! segmentation GO:0035282 78 43 1,000 0,02606432 0,10507449 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,02606432 0,10490139 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,02720251 0,10930219 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,02720251 0,10912271 ! hexose transport GO:0008645 68 44 1,000 0,02720251 0,10894382 GO:0015749|monosaccharide transport, ! heterocycle biosynthetic process GO:0018130 76 44 1,000 0,02720251 0,10876551 ! double-strand break repair GO:0006302 85 44 1,000 0,02720251 0,10858779 ! biopolymer methylation GO:0043414 91 45 1,000 0,02836044 0,11302536 ! B cell differentiation GO:0030183 124 45 1,000 0,02836044 0,11284128 ! female gamete generation GO:0007292 71 45 1,000 0,02836044 0,1126578 ! polyol metabolic process GO:0019751 77 45 1,000 0,02836044 0,11247492 ! developmental growth GO:0048589 88 45 1,000 0,02836044 0,11229262 ! maintenance of location in cell GO:0051651 101 45 1,000 0,02836044 0,11211092 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02878325 0,1135985 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02878325 0,11341527 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02878325 0,11323264 ! neuron fate determination GO:0048664 7 5 0,000 0,02878325 0,1130506 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02878325 0,11286913 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02878325 0,11268825 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02878325 0,11250795 ! polyol transport GO:0015791 12 5 0,000 0,02878325 0,11232823 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02878325 0,11214908 ! response to superoxide GO:0000303 10 5 0,000 0,02878325 0,11197049 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02878325 0,11179248 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02878325 0,11161503 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02878325 0,11143815 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02878325 0,11126182 ! female meiosis GO:0007143 10 5 0,000 0,02878325 0,11108605 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02878325 0,11091084 ! hypothalamus development GO:0021854 9 5 0,000 0,02878325 0,11073617 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02878325 0,11056206 ! cobalt ion transport GO:0006824 11 5 0,000 0,02878325 0,11038849 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02878325 0,11021547 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02878325 0,11004299 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02878325 0,10987105 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02878325 0,10969964 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02878325 0,10952877 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02878325 0,10935843 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02878325 0,10918862 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02878325 0,10901933 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02878325 0,10885057 ! transposition GO:0032196 9 5 0,000 0,02878325 0,10868233 ! negative chemotaxis GO:0050919 16 5 0,000 0,02878325 0,10851461 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02878325 0,10834741 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02878325 0,10818072 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02878325 0,10801455 ! behavioral response to pain GO:0048266 10 5 0,000 0,02878325 0,10784888 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02878325 0,10768372 ! Notch receptor processing GO:0007220 11 5 0,000 0,02878325 0,10751907 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02878325 0,10735492 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! micturition GO:0060073 9 5 0,000 0,02878325 0,10719127 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02878325 0,10702811 ! copulation GO:0007620 9 5 0,000 0,02878325 0,10686546 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02878325 0,10670329 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02878325 0,10654162 ! bioluminescence GO:0008218 9 5 0,000 0,02878325 0,10638044 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02878325 0,10621974 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02878325 0,10605953 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02878325 0,1058998 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02878325 0,10574056 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02878325 0,10558179 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02878325 0,10542349 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02878325 0,10526567 ! grooming behavior GO:0007625 6 5 0,000 0,02878325 0,10510833 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02878325 0,10495145 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02878325 0,10479504 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02878325 0,10463909 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02878325 0,10448361 ! response to protozoan GO:0001562 13 5 0,000 0,02878325 0,10432859 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,02878325 0,10417403 ! lymph vessel development GO:0001945 10 5 0,000 0,02878325 0,10401993 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02878325 0,10386628 ! endochondral ossification GO:0001958 17 5 0,000 0,02878325 0,10371308 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02878325 0,10356034 ! single strand break repair GO:0000012 8 5 0,000 0,02878325 0,10340804 ! parathyroid gland development GO:0060017 14 5 0,000 0,02878325 0,1032562 ! anagen GO:0042640 7 5 0,000 0,02878325 0,1031048 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02878325 0,10295384 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02878325 0,10280332 ! cytokine secretion GO:0050663 15 5 0,000 0,02878325 0,10265324 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02878325 0,1025036 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02878325 0,1023544 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02878325 0,10220563 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02878325 0,10205729 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02878325 0,10190938 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02878325 0,1017619 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02878325 0,10161484 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02878325 0,10146821 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02878325 0,101322 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02878325 0,10117622 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02878325 0,10103085 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02878325 0,1008859 ! microvillus organization GO:0032528 8 5 0,000 0,02878325 0,10074136 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02878325 0,10059724 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02878325 0,10045353 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02878325 0,10031023 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02878325 0,10016734 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02878325 0,10002485 ! polyol catabolic process GO:0046174 9 5 0,000 0,02878325 0,09988277 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02878325 0,09974109 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02878325 0,09959982 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02878325 0,09945894 ! mitochondrial fission GO:0000266 8 5 0,000 0,02878325 0,09931846 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02878325 0,09917838 ! mRNA transcription GO:0009299 10 5 0,000 0,02878325 0,09903869 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02878325 0,0988994 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02878325 0,09876049 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02878325 0,09862198 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02878325 0,09848385 ! monocyte activation GO:0042117 10 5 0,000 0,02878325 0,09834611 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02878325 0,09820876 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02878325 0,09807179 ! response to food GO:0032094 6 5 0,000 0,02878325 0,0979352 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02878325 0,09779899 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02878325 0,09766315 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02878325 0,0975277 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02878325 0,09739262 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,02878325 0,09725791 ! forebrain neuron development GO:0021884 13 5 0,000 0,02878325 0,09712358 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02878325 0,09698961 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02878325 0,09685602 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02878325 0,09672279 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02878325 0,09658993 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02878325 0,09645744 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02878325 0,0963253 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02878325 0,09619353 ! lipid glycosylation GO:0030259 7 5 0,000 0,02878325 0,09606212 ! nucleobase transport GO:0015851 6 5 0,000 0,02878325 0,09593106 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02878325 0,09580037 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02878325 0,09567003 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02878325 0,09554004 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02878325 0,09541041 ! basic amino acid transport GO:0015802 12 5 0,000 0,02878325 0,09528113 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02878325 0,09515219 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02878325 0,09502361 ! actin nucleation GO:0045010 11 5 0,000 0,02878325 0,09489537 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02878325 0,09476748 ! depurination GO:0045007 5 5 0,000 0,02878325 0,09463993 ! depyrimidination GO:0045008 10 5 0,000 0,02878325 0,09451273 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02878325 0,09438587 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02878325 0,09425934 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02878325 0,09413316 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02878325 0,09400731 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02878325 0,0938818 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02878325 0,09375663 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02878325 0,09363178 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02878325 0,09350727 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02878325 0,09338309 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02878325 0,09325924 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02878325 0,09313572 ! response to arsenic GO:0046685 11 5 0,000 0,02878325 0,09301253 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02878325 0,09288966 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02878325 0,09276711 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02878325 0,09264489 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02878325 0,09252299 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02878325 0,09240141 ! response to mercury ion GO:0046689 8 5 0,000 0,02878325 0,09228014 ! response to cadmium ion GO:0046686 7 5 0,000 0,02878325 0,0921592 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02878325 0,09203857 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02878325 0,09191826 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02878325 0,09179826 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02878325 0,09167858 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02878325 0,09155921 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02878325 0,09144014 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02878325 0,09132139 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02878325 0,09120294 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02878325 0,09108481 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02878325 0,09096697 ! embryonic cleavage GO:0040016 6 5 0,000 0,02878325 0,09084944 ! peroxisome fission GO:0016559 5 5 0,000 0,02878325 0,09073222 ! histone demethylation GO:0016577 13 5 0,000 0,02878325 0,0906153 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02878325 0,09049867 ! mitotic recombination GO:0006312 9 5 0,000 0,02878325 0,09038235 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02878325 0,09026633 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02878325 0,0901506 ! metaphase plate congression GO:0051310 7 5 0,000 0,02878325 0,09003517 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02878325 0,08992004 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02878325 0,0898052 ! enteric nervous system development GO:0048484 8 5 0,000 0,02878325 0,08969065 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02878325 0,0895764 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02878325 0,08946243 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02878325 0,08934876 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02878325 0,08923537 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02878325 0,08912227 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02878325 0,08900946 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02878325 0,08889693 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02878325 0,08878468 ! metaphase GO:0051323 11 5 0,000 0,02878325 0,08867272 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02878325 0,08856105 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02878325 0,08844965 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02878325 0,08833853 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02878325 0,08822769 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02878325 0,08811713 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02878325 0,08800685 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02878325 0,08789684 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02878325 0,0877871 ! response to redox state GO:0051775 6 5 0,000 0,02878325 0,08767764 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02878325 0,08756846 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02878325 0,08745954 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02878325 0,08735089 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02878325 0,08724252 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02878325 0,08713441 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02878325 0,08702657 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02878325 0,086919 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02878325 0,08681169 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02878325 0,08670465 ! striatum development GO:0021756 14 5 0,000 0,02878325 0,08659787 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02878325 0,08649135 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02878325 0,0863851 ! glial cell migration GO:0008347 10 5 0,000 0,02878325 0,0862791 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02878325 0,08617337 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02878325 0,0860679 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02878325 0,08596268 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02878325 0,08585772 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02878325 0,08575301 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02878325 0,08564856 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02878325 0,08554437 ! neuroprotection GO:0043526 8 5 0,000 0,02878325 0,08544043 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02878325 0,08533674 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02878325 0,0852333 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02878325 0,08513011 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02878325 0,08502717 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02878325 0,08492448 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02878325 0,08482204 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02878325 0,08471984 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02878325 0,08461789 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,02878325 0,08451619 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02878325 0,08441473 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02878325 0,08431351 ! spindle assembly GO:0051225 6 5 0,000 0,02878325 0,08421254 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02878325 0,08411181 GO:0022011|myelination in the peripheral nervous system, ! protein palmitoylation GO:0018345 12 5 0,000 0,02878325 0,08401131 ! drug metabolic process GO:0017144 7 5 0,000 0,02878325 0,08391106 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02878325 0,08381105 ! organ regeneration GO:0031100 7 5 0,000 0,02878325 0,08371127 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02878325 0,08361174 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02878325 0,08351244 ! negative regulation of cell migration GO:0030336 122 46 1,000 0,02953784 0,08560018 ! neural tube development GO:0021915 91 47 1,000 0,03073446 0,08896244 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,03195004 0,09237153 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,03195004 0,09226234 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,03195004 0,09215341 ! mitochondrial transport GO:0006839 94 48 1,000 0,03195004 0,09204474 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,03195004 0,09193633 ! endosome transport GO:0016197 127 48 1,000 0,03195004 0,09182817 ! methylation GO:0032259 97 48 1,000 0,03195004 0,09172026 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,0331843 0,09515171 ! protein homooligomerization GO:0051260 84 49 1,000 0,0331843 0,09504016 ! regulation of action potential GO:0001508 102 50 1,000 0,03443701 0,09851242 ! regulation of ossification GO:0030278 123 50 1,000 0,03443701 0,0983972 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,03443701 0,09828225 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03444018 0,09817662 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03444018 0,0980622 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03444018 0,09794804 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03444018 0,09783415 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03444018 0,09772052 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03444018 0,09760715 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03444018 0,09749405 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03444018 0,09738121 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03444018 0,09726863 ! response to oxygen radical GO:0000305 11 6 0,000 0,03444018 0,09715631 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03444018 0,09704425 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03444018 0,09693245 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03444018 0,0968209 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03444018 0,09670962 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03444018 0,09659858 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03444018 0,09648781 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03444018 0,09637728 ! forebrain regionalization GO:0021871 9 6 0,000 0,03444018 0,09626701 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03444018 0,09615699 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03444018 0,09604722 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03444018 0,0959377 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03444018 0,09582844 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03444018 0,09571942 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03444018 0,09561064 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03444018 0,09550212 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03444018 0,09539384 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03444018 0,09528581 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03444018 0,09517802 ! malate metabolic process GO:0006108 13 6 0,000 0,03444018 0,09507047 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03444018 0,09496317 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03444018 0,09485611 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03444018 0,09474929 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03444018 0,09464271 ! protein refolding GO:0042026 15 6 0,000 0,03444018 0,09453637 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03444018 0,09443027 ! opsonization GO:0008228 8 6 0,000 0,03444018 0,0943244 ! mating behavior GO:0007617 7 6 0,000 0,03444018 0,09421878 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03444018 0,09411339 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,03444018 0,09400823 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03444018 0,09390331 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03444018 0,09379862 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03444018 0,09369417 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03444018 0,09358995 ! toxin metabolic process GO:0009404 11 6 0,000 0,03444018 0,09348596 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03444018 0,0933822 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03444018 0,09327868 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03444018 0,09317538 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03444018 0,09307231 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03444018 0,09296947 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03444018 0,09286685 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03444018 0,09276446 ! thymic T cell selection GO:0045061 16 6 0,000 0,03444018 0,0926623 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03444018 0,09256036 ! protein lipoylation GO:0009249 10 6 0,000 0,03444018 0,09245864 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03444018 0,09235715 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03444018 0,09225588 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03444018 0,09215484 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03444018 0,09205401 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03444018 0,09195341 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03444018 0,09185302 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03444018 0,09175285 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03444018 0,0916529 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03444018 0,09155317 ! hyperosmotic response GO:0006972 10 6 0,000 0,03444018 0,09145366 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03444018 0,09135436 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03444018 0,09125528 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03444018 0,09115641 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03444018 0,09105776 ! urea metabolic process GO:0019627 7 6 0,000 0,03444018 0,09095931 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03444018 0,09086109 ! neutrophil activation GO:0042119 7 6 0,000 0,03444018 0,09076307 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03444018 0,09066527 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03444018 0,09056767 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03444018 0,09047029 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03444018 0,09037311 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03444018 0,09027614 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03444018 0,09017939 ! neuron apoptosis GO:0051402 15 6 0,000 0,03444018 0,09008283 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03444018 0,08998649 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03444018 0,08989035 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03444018 0,08979441 ! carnitine transport GO:0015879 10 6 0,000 0,03444018 0,08969868 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03444018 0,08960316 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03444018 0,08950784 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03444018 0,08941272 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03444018 0,0893178 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03444018 0,08922308 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03444018 0,08912857 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03444018 0,08903425 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03444018 0,08894013 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03444018 0,08884622 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03444018 0,0887525 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,03444018 0,08865897 ! astrocyte development GO:0014002 16 6 0,000 0,03444018 0,08856565 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03444018 0,08847252 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03444018 0,08837959 ! interaction with symbiont GO:0051702 14 6 0,000 0,03444018 0,08828685 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03444018 0,0881943 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03444018 0,08810195 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03444018 0,0880098 ! response to copper ion GO:0046688 10 6 0,000 0,03444018 0,08791783 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03444018 0,08782606 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03444018 0,08773448 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03444018 0,08764309 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03444018 0,08755189 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03444018 0,08746088 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03444018 0,08737006 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03444018 0,08727943 ! hair follicle maturation GO:0048820 8 6 0,000 0,03444018 0,08718898 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03444018 0,08709872 ! Schwann cell development GO:0014044 15 6 0,000 0,03444018 0,08700865 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03444018 0,08691877 ! response to pheromone GO:0019236 6 6 0,000 0,03444018 0,08682907 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03444018 0,08673955 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03444018 0,08665022 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03444018 0,08656108 ! subpallium development GO:0021544 15 6 0,000 0,03444018 0,08647211 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03444018 0,08638333 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03444018 0,08629473 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03444018 0,08620632 ! G2 phase GO:0051319 16 6 0,000 0,03444018 0,08611808 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03444018 0,08603003 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03444018 0,08594215 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03444018 0,08585446 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03444018 0,08576694 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03444018 0,0856796 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03444018 0,08559244 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03444018 0,08550545 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03444018 0,08541865 ! receptor internalization GO:0031623 11 6 0,000 0,03444018 0,08533201 ! plasminogen activation GO:0031639 9 6 0,000 0,03444018 0,08524556 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03444018 0,08515928 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03444018 0,08507317 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03444018 0,08498724 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03444018 0,08490148 ! protein destabilization GO:0031648 9 6 0,000 0,03444018 0,08481589 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03444018 0,08473048 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03444018 0,08464524 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03444018 0,08456017 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03444018 0,08447527 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03444018 0,08439054 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03444018 0,08430598 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03444018 0,08422159 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03444018 0,08413737 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03444018 0,08405331 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03444018 0,08396943 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03444018 0,08388571 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03444018 0,08380216 ! neural plate development GO:0001840 9 6 0,000 0,03444018 0,08371877 ! catecholamine transport GO:0051937 9 6 0,000 0,03444018 0,08363555 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03444018 0,0835525 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03444018 0,08346961 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03444018 0,08338688 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03444018 0,08330432 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03444018 0,08322193 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03444018 0,08313969 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03444018 0,08305762 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03444018 0,08297571 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03444018 0,08289396 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03444018 0,08281237 GO:0055081|anion homeostasis, ! response to temperature stimulus GO:0009266 84 51 1,000 0,03570789 0,08577619 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,03570789 0,08569193 ! positive regulation of binding GO:0051099 88 52 1,000 0,03699671 0,08869771 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,03699671 0,08861075 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,03699671 0,08852396 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,03699671 0,08843734 ! histone modification GO:0016570 104 52 1,000 0,03699671 0,08835089 ! vesicle organization GO:0016050 127 53 1,000 0,03830321 0,09138158 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,03830321 0,09129243 ! synapse organization GO:0050808 102 53 1,000 0,03830321 0,09120345 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,03962714 0,09426397 GO:0010863|positive regulation of phospholipase C activity, ! membrane fusion GO:0006944 122 54 1,000 0,03962714 0,09417228 ! covalent chromatin modification GO:0016569 115 54 1,000 0,03962714 0,09408076 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,03962714 0,09398942 ! tRNA transcription GO:0009304 17 7 0,000 0,04006433 0,09493419 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04006433 0,0948422 GO:0045346|regulation of MHC class II biosynthetic process, ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04006433 0,09475039 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,04006433 0,09465876 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04006433 0,0945673 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04006433 0,09447602 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04006433 0,09438491 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04006433 0,09429398 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04006433 0,09420323 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04006433 0,09411265 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04006433 0,09402224 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04006433 0,09393201 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04006433 0,09384195 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04006433 0,09375206 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04006433 0,09366235 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04006433 0,0935728 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04006433 0,09348343 ! glycolipid transport GO:0046836 11 7 0,000 0,04006433 0,09339423 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04006433 0,0933052 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04006433 0,09321634 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04006433 0,09312764 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04006433 0,09303912 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04006433 0,09295076 ! mRNA stabilization GO:0048255 18 7 0,000 0,04006433 0,09286257 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,04006433 0,09277455 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04006433 0,0926867 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04006433 0,09259901 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04006433 0,09251149 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04006433 0,09242413 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04006433 0,09233694 ! rhythmic behavior GO:0007622 17 7 0,000 0,04006433 0,09224991 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04006433 0,09216304 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04006433 0,09207634 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04006433 0,09198981 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04006433 0,09190343 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04006433 0,09181722 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04006433 0,09173117 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04006433 0,09164528 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04006433 0,09155955 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04006433 0,09147398 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04006433 0,09138857 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04006433 0,09130332 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04006433 0,09121822 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04006433 0,09113329 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04006433 0,09104852 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04006433 0,0909639 ! spinal cord patterning GO:0021511 14 7 0,000 0,04006433 0,09087944 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04006433 0,09079513 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04006433 0,09071099 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04006433 0,09062699 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04006433 0,09054316 ! adrenal gland development GO:0030325 17 7 0,000 0,04006433 0,09045948 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04006433 0,09037595 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04006433 0,09029258 ! ovulation GO:0030728 10 7 0,000 0,04006433 0,09020936 ! adenohypophysis development GO:0021984 11 7 0,000 0,04006433 0,09012629 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04006433 0,09004338 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04006433 0,08996062 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04006433 0,08987801 ! microtubule nucleation GO:0007020 21 7 0,000 0,04006433 0,08979555 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04006433 0,08971325 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04006433 0,08963109 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04006433 0,08954909 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04006433 0,08946723 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04006433 0,08938553 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04006433 0,08930397 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04006433 0,08922256 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04006433 0,08914131 ! galactose metabolic process GO:0006012 13 7 0,000 0,04006433 0,08906019 ! vesicle fusion GO:0006906 20 7 0,000 0,04006433 0,08897923 ! response to dietary excess GO:0002021 8 7 0,000 0,04006433 0,08889841 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04006433 0,08881774 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04006433 0,08873722 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04006433 0,08865684 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,04006433 0,08857661 ! nucleoside transport GO:0015858 11 7 0,000 0,04006433 0,08849652 ! nucleoside salvage GO:0043174 11 7 0,000 0,04006433 0,08841658 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04006433 0,08833678 ! male sex determination GO:0030238 15 7 0,000 0,04006433 0,08825713 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04006433 0,08817762 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! parturition GO:0007567 16 7 0,000 0,04006433 0,08809825 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,04006433 0,08801902 ! rRNA modification GO:0000154 14 7 0,000 0,04006433 0,08793994 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04006433 0,087861 ! spindle checkpoint GO:0031577 16 7 0,000 0,04006433 0,0877822 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04006433 0,08770354 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04006433 0,08762503 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04006433 0,08754665 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,04006433 0,08746841 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04006433 0,08739032 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,04006433 0,08731236 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04006433 0,08723454 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04006433 0,08715686 ! eating behavior GO:0042755 8 7 0,000 0,04006433 0,08707932 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04006433 0,08700191 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04006433 0,08692465 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04006433 0,08684752 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04006433 0,08677053 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,04006433 0,08669367 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04006433 0,08661695 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,04006433 0,08654037 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04006433 0,08646392 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04006433 0,0863876 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04006433 0,08631142 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04006433 0,08623538 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04006433 0,08615947 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04006433 0,08608369 ! histone ubiquitination GO:0016574 9 7 0,000 0,04006433 0,08600804 ! regulation of meiosis GO:0040020 12 7 0,000 0,04006433 0,08593253 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04006433 0,08585715 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04006433 0,08578191 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04006433 0,08570679 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04006433 0,08563181 ! transcription termination GO:0006353 14 7 0,000 0,04006433 0,08555695 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04006433 0,08548223 ! anaphase GO:0051322 18 7 0,000 0,04006433 0,08540764 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04006433 0,08533318 ! axonal fasciculation GO:0007413 19 7 0,000 0,04006433 0,08525884 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04006433 0,08518464 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04006433 0,08511057 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04006433 0,08503662 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04006433 0,08496281 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04006433 0,08488912 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04006433 0,08481556 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04006433 0,08474212 ! antibiotic transport GO:0042891 9 7 0,000 0,04006433 0,08466882 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04006433 0,08459564 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04006433 0,08452259 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04006433 0,08444966 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04006433 0,08437686 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04006433 0,08430418 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04006433 0,08423163 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04006433 0,0841592 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04006433 0,0840869 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04006433 0,08401472 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04006433 0,08394267 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04006433 0,08387074 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04006433 0,08379893 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04006433 0,08372725 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04006433 0,08365569 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04006433 0,08358425 ! muscle adaptation GO:0043500 13 7 0,000 0,04006433 0,08351293 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04006433 0,08344173 ! retina homeostasis GO:0001895 12 7 0,000 0,04006433 0,08337066 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04006433 0,08329971 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04006433 0,08322887 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04006433 0,08315816 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04006433 0,08308757 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,04096826 0,08489012 ! negative regulation of cell motion GO:0051271 142 55 1,000 0,04096826 0,08481818 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,04232632 0,08755563 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,04232632 0,08748156 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,04370109 0,09024663 ! muscle fiber development GO:0048747 131 57 1,000 0,04370109 0,09017041 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,04370109 0,09009431 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,04509232 0,09288411 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,04509232 0,09280585 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,04509232 0,09272773 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 1,000 0,04509232 0,09264975 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,04509232 0,09257189 ! maintenance of location GO:0051235 124 58 1,000 0,04509232 0,09249416 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04565587 0,09357156 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04565587 0,09349312 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,04565587 0,09341482 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,04565587 0,09333665 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04565587 0,09325861 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04565587 0,0931807 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04565587 0,09310292 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04565587 0,09302527 ! male meiosis GO:0007140 9 8 0,000 0,04565587 0,09294775 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04565587 0,09287035 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04565587 0,09279309 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04565587 0,09271596 ! meiotic prophase I GO:0007128 14 8 0,000 0,04565587 0,09263895 ! response to zinc ion GO:0010043 12 8 0,000 0,04565587 0,09256207 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04565587 0,09248532 ! oligopeptide transport GO:0006857 16 8 0,000 0,04565587 0,09240869 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04565587 0,0923322 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04565587 0,09225583 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04565587 0,09217958 ! signal peptide processing GO:0006465 12 8 0,000 0,04565587 0,09210346 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04565587 0,09202747 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04565587 0,0919516 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04565587 0,09187586 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04565587 0,09180024 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04565587 0,09172475 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04565587 0,09164938 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04565587 0,09157413 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04565587 0,09149901 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04565587 0,09142401 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04565587 0,09134914 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04565587 0,09127438 ! reflex GO:0060004 17 8 0,000 0,04565587 0,09119975 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04565587 0,09112524 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04565587 0,09105085 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04565587 0,09097659 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04565587 0,09090244 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04565587 0,09082842 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04565587 0,09075451 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04565587 0,09068073 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04565587 0,09060706 ! histidine catabolic process GO:0006548 10 8 0,000 0,04565587 0,09053352 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04565587 0,09046009 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04565587 0,09038679 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04565587 0,0903136 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04565587 0,09024053 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04565587 0,09016758 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04565587 0,09009475 ! macrophage activation GO:0042116 13 8 0,000 0,04565587 0,09002203 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04565587 0,08994943 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04565587 0,08987695 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04565587 0,08980459 ! purine salvage GO:0043101 12 8 0,000 0,04565587 0,08973234 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04565587 0,0896602 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04565587 0,08958819 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04565587 0,08951629 ! osteoblast development GO:0002076 17 8 0,000 0,04565587 0,0894445 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04565587 0,08937283 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04565587 0,08930128 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04565587 0,08922984 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04565587 0,08915851 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04565587 0,0890873 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04565587 0,0890162 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04565587 0,08894521 ! intermediate filament organization GO:0045109 12 8 0,000 0,04565587 0,08887434 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04565587 0,08880358 ! cellular extravasation GO:0045123 13 8 0,000 0,04565587 0,08873293 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04565587 0,0886624 ! response to antibiotic GO:0046677 11 8 0,000 0,04565587 0,08859197 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04565587 0,08852166 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04565587 0,08845146 ! DNA topological change GO:0006265 12 8 0,000 0,04565587 0,08838137 ! response to tropane GO:0014073 15 8 0,000 0,04565587 0,0883114 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04565587 0,08824153 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04565587 0,08817177 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04565587 0,08810213 ! mast cell activation GO:0045576 14 8 0,000 0,04565587 0,08803259 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04565587 0,08796317 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04565587 0,08789385 ! gas homeostasis GO:0033483 14 8 0,000 0,04565587 0,08782464 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04565587 0,08775554 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04565587 0,08768655 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04565587 0,08761767 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04565587 0,0875489 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04565587 0,08748023 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04565587 0,08741167 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04565587 0,08734322 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04565587 0,08727488 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04565587 0,08720664 ! response to tumor cell GO:0002347 16 8 0,000 0,04565587 0,08713851 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04565587 0,08707049 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04565587 0,08700257 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04565587 0,08693476 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04565587 0,08686705 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04565587 0,08679945 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04565587 0,08673196 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04565587 0,08666456 ! hormone catabolic process GO:0042447 17 8 0,000 0,04565587 0,08659728 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04565587 0,0865301 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04565587 0,08646302 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04565587 0,08639605 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04565587 0,08632918 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04565587 0,08626241 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04565587 0,08619575 ! adult feeding behavior GO:0008343 10 8 0,000 0,04565587 0,08612919 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04565587 0,08606273 ! ATP catabolic process GO:0006200 11 8 0,000 0,04565587 0,08599637 ! blastocyst growth GO:0001832 19 8 0,000 0,04565587 0,08593012 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04565587 0,08586397 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04565587 0,08579792 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04565587 0,08573197 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04565587 0,08566612 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04565587 0,08560038 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04565587 0,08553474 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04565587 0,08546919 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04565587 0,08540375 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04565587 0,0853384 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04565587 0,08527316 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04565587 0,08520802 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04565587 0,08514297 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04565587 0,08507803 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04565587 0,08501318 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04565587 0,08494843 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04565587 0,08488379 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04565587 0,08481924 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04565587 0,08475478 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04565587 0,08469043 ! regulation of neurotransmitter levels GO:0001505 113 60 1,000 0,04792325 0,0888289 ! heterocycle catabolic process GO:0046700 100 60 1,000 0,04792325 0,08876156 ! kidney development GO:0001822 133 60 1,000 0,04792325 0,08869431 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,04936247 0,09128881 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,05081723 0,09390808 ! axon extension GO:0048675 16 9 0,000 0,051215 0,09457162 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,051215 0,09450019 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,051215 0,09442887 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,051215 0,09435765 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,051215 0,09428655 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,051215 0,09421555 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,051215 0,09414466 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,051215 0,09407387 ! reproductive behavior GO:0019098 22 9 0,000 0,051215 0,09400319 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,051215 0,09393262 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,051215 0,09386215 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,051215 0,09379179 ! UTP metabolic process GO:0046051 10 9 0,000 0,051215 0,09372153 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,051215 0,09365138 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,051215 0,09358134 ! artery development GO:0060840 25 9 0,000 0,051215 0,0935114 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,051215 0,09344156 ! regulation of glycolysis GO:0006110 20 9 0,000 0,051215 0,09337183 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,051215 0,0933022 ! equilibrioception GO:0050957 20 9 0,000 0,051215 0,09323267 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,051215 0,09316325 ! chemosensory behavior GO:0007635 21 9 0,000 0,051215 0,09309394 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,051215 0,09302472 ! leukocyte degranulation GO:0043299 16 9 0,000 0,051215 0,09295561 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,051215 0,0928866 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,051215 0,09281769 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,051215 0,09274889 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,051215 0,09268018 ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,051215 0,09261158 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,051215 0,09254308 ! protein targeting to ER GO:0045047 25 9 0,000 0,051215 0,09247468 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,051215 0,09240639 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,051215 0,09233819 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,051215 0,09227009 ! glycine catabolic process GO:0006546 15 9 0,000 0,051215 0,0922021 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,051215 0,0921342 ! endosome organization GO:0007032 20 9 0,000 0,051215 0,09206641 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,051215 0,09199871 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,051215 0,09193112 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,051215 0,09186362 ! mannose metabolic process GO:0006013 13 9 0,000 0,051215 0,09179622 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,051215 0,09172892 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,051215 0,09166172 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,051215 0,09159462 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,051215 0,09152761 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,051215 0,09146071 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,051215 0,0913939 ! retinol metabolic process GO:0042572 20 9 0,000 0,051215 0,09132719 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,051215 0,09126058 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,051215 0,09119406 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,051215 0,09112764 ! oligodendrocyte development GO:0014003 11 9 0,000 0,051215 0,09106132 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,051215 0,09099509 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,051215 0,09092896 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,051215 0,09086293 ! establishment of melanosome localization GO:0032401 14 9 0,000 0,051215 0,09079699 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,051215 0,09073114 ! erythrocyte development GO:0048821 17 9 0,000 0,051215 0,0906654 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,051215 0,09059975 ! renal water homeostasis GO:0003091 15 9 0,000 0,051215 0,09053419 ! postreplication repair GO:0006301 25 9 0,000 0,051215 0,09046873 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,051215 0,09040336 ! icosanoid secretion GO:0032309 15 9 0,000 0,051215 0,09033809 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,051215 0,09027291 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,051215 0,09020782 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,051215 0,09014283 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,051215 0,09007793 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,051215 0,09001313 ! sterol catabolic process GO:0016127 14 9 0,000 0,051215 0,08994842 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,051215 0,0898838 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,051215 0,08981927 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,051215 0,08975484 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,051215 0,0896905 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,051215 0,08962625 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,051215 0,0895621 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,051215 0,08949803 ! purine base metabolic process GO:0006144 25 9 0,000 0,051215 0,08943406 ! pigment granule transport GO:0051904 17 9 0,000 0,051215 0,08937018 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,051215 0,08930639 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,051215 0,08924269 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,051215 0,08917908 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,051215 0,08911556 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,051215 0,08905213 ! mitochondrion localization GO:0051646 18 9 0,000 0,051215 0,0889888 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,05228729 0,09078738 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,05377243 0,09329975 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,05527243 0,09583431 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,0567419 0,09831239 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,0567419 0,09824272 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,0567419 0,09817314 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,0567419 0,09810366 ! associative learning GO:0008306 21 10 0,000 0,0567419 0,09803428 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0567419 0,097965 ! phosphate transport GO:0006817 24 10 0,000 0,0567419 0,09789581 ! cell volume homeostasis GO:0006884 17 10 0,000 0,0567419 0,09782673 ! CTP metabolic process GO:0046036 11 10 0,000 0,0567419 0,09775774 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,0567419 0,09768885 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,0567419 0,09762005 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,0567419 0,09755135 ! social behavior GO:0035176 29 10 0,000 0,0567419 0,09748275 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,0567419 0,09741425 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,0567419 0,09734584 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,0567419 0,09727752 ! androgen metabolic process GO:0008209 17 10 0,000 0,0567419 0,09720931 ! phospholipid efflux GO:0033700 19 10 0,000 0,0567419 0,09714119 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,0567419 0,09707316 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,0567419 0,09700523 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,0567419 0,09693739 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,0567419 0,09686965 ! lung alveolus development GO:0048286 26 10 0,000 0,0567419 0,09680201 ! pathogenesis GO:0009405 17 10 0,000 0,0567419 0,09673445 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0567419 0,096667 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,0567419 0,09659963 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,0567419 0,09653236 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,0567419 0,09646519 ! endoderm development GO:0007492 18 10 0,000 0,0567419 0,0963981 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,0567419 0,09633111 ! arginine catabolic process GO:0006527 17 10 0,000 0,0567419 0,09626422 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0567419 0,09619741 ! proline metabolic process GO:0006560 13 10 0,000 0,0567419 0,0961307 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,0567419 0,09606408 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,0567419 0,09599756 ! V(D)J recombination GO:0033151 34 10 0,000 0,0567419 0,09593112 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,0567419 0,09586478 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,0567419 0,09579853 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,0567419 0,09573237 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,0567419 0,0956663 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,0567419 0,09560033 ! multicellular organism growth GO:0035264 19 10 0,000 0,0567419 0,09553444 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,0567419 0,09546864 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,0567419 0,09540294 ! ruffle organization GO:0031529 17 10 0,000 0,0567419 0,09533733 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,0567419 0,0952718 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0567419 0,09520637 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,0567419 0,09514102 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,0567419 0,09507577 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,0567419 0,0950106 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,0567419 0,09494553 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,0567419 0,09488054 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0567419 0,09481564 ! regulation of bone resorption GO:0045124 25 10 0,000 0,0567419 0,09475084 ! protein heterooligomerization GO:0051291 17 10 0,000 0,0567419 0,09468612 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,0567419 0,09462148 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,0567419 0,09455694 ! segment specification GO:0007379 15 10 0,000 0,0567419 0,09449248 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,0567419 0,09442811 ! blastoderm segmentation GO:0007350 19 10 0,000 0,0567419 0,09436383 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,0567419 0,09429964 ! response to dsRNA GO:0043331 23 10 0,000 0,0567419 0,09423554 ! DNA ligation GO:0006266 18 10 0,000 0,0567419 0,09417152 ! melanosome localization GO:0032400 16 10 0,000 0,0567419 0,09410758 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,0567419 0,09404374 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,0567419 0,09397998 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,0567419 0,09391631 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0567419 0,09385272 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,0567419 0,09378922 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,0567419 0,09372581 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,0567419 0,09366248 ! protein sumoylation GO:0016925 17 10 0,000 0,0567419 0,09359924 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,0567419 0,09353608 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0567419 0,09347301 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0567419 0,09341002 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0567419 0,09334712 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,0567419 0,0932843 ! salivary gland development GO:0007431 28 10 0,000 0,0567419 0,09322157 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,0567419 0,09315892 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,0567419 0,09309635 ! musculoskeletal movement GO:0050881 16 10 0,000 0,0567419 0,09303387 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,0567419 0,09297148 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,0567419 0,09290916 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,0567419 0,09284693 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,0567419 0,09278479 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,0567419 0,09272272 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0567419 0,09266074 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0567419 0,09259885 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,0567419 0,09253703 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,0567419 0,0924753 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,0567419 0,09241365 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0567419 0,09235208 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,0567419 0,09229059 ! cerebellar cortex development GO:0021695 16 10 0,000 0,0567419 0,09222919 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,0567419 0,09216787 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,0567419 0,09210663 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,0567419 0,09204547 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,0567419 0,09198439 ! gonad development GO:0008406 115 66 1,000 0,05678706 0,09199655 ! activation of MAPK activity GO:0000187 124 67 1,000 0,05831611 0,09441104 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,05831611 0,09434852 GO:0035113|embryonic appendage morphogenesis, ! secondary metabolic process GO:0019748 125 67 1,000 0,05831611 0,09428608 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,05985936 0,09671721 ! extracellular matrix organization GO:0030198 146 68 1,000 0,05985936 0,09665328 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,05985936 0,09658944 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,05985936 0,09652569 ! regulation of lipase activity GO:0060191 137 68 1,000 0,05985936 0,09646202 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,05985936 0,09639843 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,06141659 0,09884106 ! cellular amino acid catabolic process GO:0009063 120 69 1,000 0,06141659 0,09877599 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,06223677 0,10002922 ! respiratory burst GO:0045730 17 11 0,000 0,06223677 0,09996346 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,06223677 0,09989778 ! neuron fate specification GO:0048665 18 11 0,000 0,06223677 0,09983219 ! telencephalon cell migration GO:0022029 23 11 0,000 0,06223677 0,09976668 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,06223677 0,09970126 ! thyroid gland development GO:0030878 26 11 0,000 0,06223677 0,09963592 ! synapsis GO:0007129 14 11 0,000 0,06223677 0,09957067 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,06223677 0,09950551 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,06223677 0,09944043 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,06223677 0,09937544 ! blood vessel remodeling GO:0001974 30 11 0,000 0,06223677 0,09931053 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,06223677 0,09924571 ! bone resorption GO:0045453 16 11 0,000 0,06223677 0,09918097 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,06223677 0,09911631 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06223677 0,09905174 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06223677 0,09898725 ! melanocyte differentiation GO:0030318 20 11 0,000 0,06223677 0,09892285 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,06223677 0,09885853 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,06223677 0,0987943 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,06223677 0,09873014 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,06223677 0,09866607 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,06223677 0,09860209 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,06223677 0,09853819 ! UV protection GO:0009650 20 11 0,000 0,06223677 0,09847437 ! adult heart development GO:0007512 16 11 0,000 0,06223677 0,09841063 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06223677 0,09834697 ! macroautophagy GO:0016236 19 11 0,000 0,06223677 0,0982834 ! temperature homeostasis GO:0001659 18 11 0,000 0,06223677 0,09821991 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,06223677 0,0981565 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,06223677 0,09809317 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,06223677 0,09802993 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,06223677 0,09796677 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,06223677 0,09790368 ! regulation of organ growth GO:0046620 14 11 0,000 0,06223677 0,09784068 ! pigment granule localization GO:0051875 20 11 0,000 0,06223677 0,09777776 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,06223677 0,09771492 ! vasoconstriction GO:0042310 20 11 0,000 0,06223677 0,09765216 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,06223677 0,09758949 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06223677 0,09752689 ! embryonic axis specification GO:0000578 19 11 0,000 0,06223677 0,09746437 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,06223677 0,09740193 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,06223677 0,09733958 ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,06223677 0,0972773 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,06223677 0,0972151 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,06223677 0,09715298 ! prophase GO:0051324 17 11 0,000 0,06223677 0,09709095 ! neuroblast proliferation GO:0007405 25 11 0,000 0,06223677 0,09702899 ! nucleosome positioning GO:0016584 15 11 0,000 0,06223677 0,0969671 ! regulation of isotype switching GO:0045191 24 11 0,000 0,06223677 0,0969053 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,06223677 0,09684358 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,06223677 0,09678194 ! apical protein localization GO:0045176 18 11 0,000 0,06223677 0,09672037 ! acid secretion GO:0046717 20 11 0,000 0,06223677 0,09665888 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06223677 0,09659747 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,06223677 0,09653614 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,06223677 0,09647489 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,06223677 0,09641371 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,06223677 0,09635261 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,06223677 0,09629159 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,06223677 0,09623065 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06223677 0,09616978 ! germ cell migration GO:0008354 26 11 0,000 0,06223677 0,09610899 ! embryonic gut development GO:0048566 19 11 0,000 0,06223677 0,09604828 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,06223677 0,09598764 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,06223677 0,09592708 ! activation of innate immune response GO:0002218 16 11 0,000 0,06223677 0,0958666 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,06223677 0,09580619 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,06223677 0,09574586 ! lysogeny GO:0030069 22 11 0,000 0,06223677 0,0956856 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06223677 0,09562542 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,06223677 0,09556532 ! sequestering of metal ion GO:0051238 15 11 0,000 0,06223677 0,09550529 ! regulation of embryonic development GO:0045995 35 11 0,000 0,06223677 0,09544534 ! germ cell development GO:0007281 133 70 1,000 0,06298759 0,09653618 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,06457215 0,09890267 ! appendage morphogenesis GO:0035107 150 72 1,000 0,06617005 0,10128661 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 1,000 0,06617005 0,10122319 ! B cell activation GO:0042113 179 72 1,000 0,06617005 0,10115985 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,06617005 0,10109658 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,06617005 0,1010334 ! coenzyme biosynthetic process GO:0009108 119 72 1,000 0,06617005 0,10097029 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06769977 0,10324004 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06769977 0,10317564 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,06769977 0,10311131 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06769977 0,10304707 ! virus-host interaction GO:0019048 30 12 0,000 0,06769977 0,1029829 ! mating GO:0007618 17 12 0,000 0,06769977 0,10291882 ! protein complex disassembly GO:0043241 28 12 0,000 0,06769977 0,10285482 GO:0043624|cellular protein complex disassembly, ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06769977 0,10279089 ! T cell proliferation GO:0042098 32 12 0,000 0,06769977 0,10272705 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06769977 0,10266328 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06769977 0,10259959 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06769977 0,10253598 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06769977 0,10247246 ! drug transport GO:0015893 16 12 0,000 0,06769977 0,10240901 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06769977 0,10234563 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06769977 0,10228234 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06769977 0,10221912 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06769977 0,10215599 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06769977 0,10209293 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06769977 0,10202995 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06769977 0,10196704 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06769977 0,10190422 ! lipid digestion GO:0044241 21 12 0,000 0,06769977 0,10184147 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06769977 0,1017788 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06769977 0,1017162 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06769977 0,10165368 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06769977 0,10159124 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06769977 0,10152888 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06769977 0,10146659 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06769977 0,10140438 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06769977 0,10134224 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06769977 0,10128019 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06769977 0,1012182 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06769977 0,1011563 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06769977 0,10109446 ! cranial nerve development GO:0021545 23 12 0,000 0,06769977 0,10103271 ! fucose catabolic process GO:0019317 25 12 0,000 0,06769977 0,10097103 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06769977 0,10090942 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,06769977 0,10084789 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06769977 0,10078644 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,06769977 0,10072506 ! zymogen activation GO:0031638 18 12 0,000 0,06769977 0,10066375 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06769977 0,10060252 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06769977 0,10054136 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,06769977 0,10048028 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06769977 0,10041927 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06769977 0,10035834 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,06769977 0,10029748 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06769977 0,10023669 ! defense response to fungus GO:0050832 15 12 0,000 0,06769977 0,10017598 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06769977 0,10011534 ! response to cold GO:0009409 17 12 0,000 0,06769977 0,10005478 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06769977 0,09999428 ! localization within membrane GO:0051668 26 12 0,000 0,06769977 0,09993386 ! appendage development GO:0048736 151 73 1,000 0,0677811 0,09999349 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 1,000 0,0677811 0,09993314 ! amino acid transport GO:0006865 148 74 1,000 0,06940508 0,10226575 ! axon guidance GO:0007411 162 75 1,000 0,07104179 0,10461429 ! rhythmic process GO:0048511 142 75 1,000 0,07104179 0,10455127 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,07269104 0,10691403 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,07313111 0,10749657 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07313111 0,10743193 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,07313111 0,10736736 ! regulation of chemokine production GO:0032642 18 13 0,000 0,07313111 0,10730288 ! peroxisomal transport GO:0043574 28 13 0,000 0,07313111 0,10723847 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,07313111 0,10717414 ! cartilage condensation GO:0001502 22 13 0,000 0,07313111 0,10710989 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,07313111 0,10704571 ! organelle fusion GO:0048284 36 13 0,000 0,07313111 0,10698161 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,07313111 0,10691759 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,07313111 0,10685364 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,07313111 0,10678977 ! endocrine pancreas development GO:0031018 25 13 0,000 0,07313111 0,10672598 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,07313111 0,10666226 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,07313111 0,10659862 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,07313111 0,10653506 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,07313111 0,10647157 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,07313111 0,10640815 ! methionine metabolic process GO:0006555 31 13 0,000 0,07313111 0,10634482 ! plasma membrane organization GO:0007009 27 13 0,000 0,07313111 0,10628155 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,07313111 0,10621837 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,07313111 0,10615525 ! response to X-ray GO:0010165 28 13 0,000 0,07313111 0,10609222 ! cytokine metabolic process GO:0042107 24 13 0,000 0,07313111 0,10602925 ! asymmetric protein localization GO:0008105 24 13 0,000 0,07313111 0,10596637 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,07313111 0,10590355 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,07313111 0,10584081 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,07313111 0,10577815 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,07313111 0,10571556 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,07313111 0,10565304 ! protein homotetramerization GO:0051289 24 13 0,000 0,07313111 0,1055906 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,07313111 0,10552823 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,07313111 0,10546593 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,07313111 0,10540371 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,07313111 0,10534156 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07313111 0,10527949 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,07313111 0,10521749 ! histone methylation GO:0016571 29 13 0,000 0,07313111 0,10515556 ! chromatin silencing GO:0006342 29 13 0,000 0,07313111 0,1050937 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,07313111 0,10503192 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,07313111 0,10497021 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07313111 0,10490857 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,07313111 0,104847 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,07313111 0,10478551 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,07313111 0,10472409 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,07313111 0,10466274 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,07313111 0,10460146 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,07313111 0,10454025 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07313111 0,10447912 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,07313111 0,10441805 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,07313111 0,10435706 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,07313111 0,10429614 ! insulin secretion GO:0030073 24 13 0,000 0,07313111 0,10423529 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,07313111 0,10417451 ! acrosome reaction GO:0007340 19 13 0,000 0,07313111 0,10411381 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,07313111 0,10405317 ! amine catabolic process GO:0009310 136 77 1,000 0,07435261 0,10572959 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,07435261 0,10566808 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,07435261 0,10560665 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,07435261 0,10554528 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,07602632 0,10785848 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,07771196 0,11018591 ! protein oligomerization GO:0051259 149 79 1,000 0,07771196 0,110122 ! rRNA transcription GO:0009303 28 14 0,000 0,07853095 0,11121804 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07853095 0,1111536 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,07853095 0,11108924 ! water transport GO:0006833 21 14 0,000 0,07853095 0,11102495 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07853095 0,11096074 ! non-recombinational repair GO:0000726 29 14 0,000 0,07853095 0,1108966 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07853095 0,11083253 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07853095 0,11076854 ! RNA polyadenylation GO:0043631 32 14 0,000 0,07853095 0,11070462 ! lipid localization GO:0010876 32 14 0,000 0,07853095 0,11064078 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,07853095 0,11057701 ! regulated secretory pathway GO:0045055 24 14 0,000 0,07853095 0,11051331 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07853095 0,11044969 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07853095 0,11038614 ! arginine metabolic process GO:0006525 21 14 0,000 0,07853095 0,11032266 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07853095 0,11025926 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,07853095 0,11019593 ! regulation of heart rate GO:0002027 25 14 0,000 0,07853095 0,11013267 ! organic alcohol transport GO:0015850 29 14 0,000 0,07853095 0,11006948 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07853095 0,11000637 ! embryo implantation GO:0007566 30 14 0,000 0,07853095 0,10994333 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07853095 0,10988036 ! bone mineralization GO:0030282 18 14 0,000 0,07853095 0,10981746 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07853095 0,10975464 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,07853095 0,10969189 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07853095 0,10962921 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07853095 0,1095666 ! regulation of cellular pH GO:0030641 27 14 0,000 0,07853095 0,10950406 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07853095 0,10944159 ! ribosome assembly GO:0042255 18 14 0,000 0,07853095 0,1093792 ! cerebellum development GO:0021549 23 14 0,000 0,07853095 0,10931687 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07853095 0,10925462 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07853095 0,10919244 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07853095 0,10913032 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07853095 0,10906828 ! NADP metabolic process GO:0006739 24 14 0,000 0,07853095 0,10900631 ! oxygen transport GO:0015671 22 14 0,000 0,07853095 0,10894441 ! regulation of RNA stability GO:0043487 33 14 0,000 0,07853095 0,10888258 ! regulation of axon extension GO:0030516 43 14 0,000 0,07853095 0,10882082 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07853095 0,10875913 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,07853095 0,10869751 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,07940935 0,1098511 ! muscle cell differentiation GO:0042692 178 81 1,000 0,08111828 0,11215165 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,08111828 0,11208822 ! lactation GO:0007595 30 15 0,000 0,08389949 0,11586571 ! reproductive cellular process GO:0048610 22 15 0,000 0,08389949 0,11580025 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08389949 0,11573486 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,08389949 0,11566955 ! superoxide anion generation GO:0042554 22 15 0,000 0,08389949 0,11560431 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,08389949 0,11553915 ! copper ion transport GO:0006825 22 15 0,000 0,08389949 0,11547405 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,08389949 0,11540903 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,08389949 0,11534409 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,08389949 0,11527922 ! sulfate transport GO:0008272 27 15 0,000 0,08389949 0,11521442 ! response to cAMP GO:0051591 25 15 0,000 0,08389949 0,11514969 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,08389949 0,11508503 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,08389949 0,11502045 ! response to hexose stimulus GO:0009746 25 15 0,000 0,08389949 0,11495594 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,08389949 0,11489151 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,08389949 0,11482714 ! vesicle coating GO:0006901 38 15 0,000 0,08389949 0,11476285 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,08389949 0,11469863 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,08389949 0,11463448 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,08389949 0,1145704 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,08389949 0,11450639 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,08389949 0,11444246 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,08389949 0,1143786 ! regulation of vasodilation GO:0042312 27 15 0,000 0,08389949 0,1143148 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,08389949 0,11425108 ! histone deacetylation GO:0016575 24 15 0,000 0,08389949 0,11418743 ! water homeostasis GO:0030104 28 15 0,000 0,08389949 0,11412386 ! cofactor transport GO:0051181 30 15 0,000 0,08389949 0,11406035 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08389949 0,11399691 ! muscle maintenance GO:0046716 26 15 0,000 0,08389949 0,11393354 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,08389949 0,11387025 ! intestinal absorption GO:0050892 31 15 0,000 0,08389949 0,11380702 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,08389949 0,11374387 ! heme biosynthetic process GO:0006783 33 15 0,000 0,08389949 0,11368078 ! cell killing GO:0001906 32 15 0,000 0,08389949 0,11361776 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,08389949 0,11355482 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,08389949 0,11349194 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,08389949 0,11342913 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,08389949 0,1133664 ! actin filament polymerization GO:0030041 27 15 0,000 0,08389949 0,11330373 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,08389949 0,11324113 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,08457005 0,11408317 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,08457005 0,11402021 ! response to metal ion GO:0010038 158 84 1,000 0,0863125 0,11630525 ! T cell activation GO:0042110 189 84 1,000 0,0863125 0,11624114 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,08806574 0,11853698 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,08806574 0,1184717 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,0892369 0,11998114 ! positive regulation of cell size GO:0045793 29 16 0,000 0,0892369 0,11991515 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,0892369 0,11984922 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,0892369 0,11978337 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,0892369 0,11971759 ! bone remodeling GO:0046849 28 16 0,000 0,0892369 0,11965189 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,0892369 0,11958625 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0892369 0,11952069 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,0892369 0,1194552 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,0892369 0,11938978 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,0892369 0,11932443 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,0892369 0,11925916 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,0892369 0,11919395 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,0892369 0,11912882 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,0892369 0,11906376 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,0892369 0,11899876 ! protein polyubiquitination GO:0000209 41 16 0,000 0,0892369 0,11893384 ! glutamate metabolic process GO:0006536 25 16 0,000 0,0892369 0,11886899 ! pituitary gland development GO:0021983 30 16 0,000 0,0892369 0,11880422 ! response to osmotic stress GO:0006970 27 16 0,000 0,0892369 0,11873951 ! lysosomal transport GO:0007041 31 16 0,000 0,0892369 0,11867487 ! fructose metabolic process GO:0006000 25 16 0,000 0,0892369 0,1186103 ! L-amino acid transport GO:0015807 33 16 0,000 0,0892369 0,11854581 ! stem cell development GO:0048864 46 16 0,000 0,0892369 0,11848138 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,0892369 0,11841702 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 36 16 0,000 0,0892369 0,11835273 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,0892369 0,11828852 ! negative regulation of immune response GO:0050777 38 16 0,000 0,0892369 0,11822437 ! axon cargo transport GO:0008088 46 16 0,000 0,0892369 0,11816029 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,0892369 0,11809628 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,0892369 0,11803234 ! DNA replication initiation GO:0006270 28 16 0,000 0,0892369 0,11796847 ! neuron recognition GO:0008038 40 16 0,000 0,0892369 0,11790467 ! mRNA splice site selection GO:0006376 44 16 0,000 0,0892369 0,11784094 ! tissue regeneration GO:0042246 27 16 0,000 0,0892369 0,11777727 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,0892369 0,11771368 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,0892369 0,11765015 ! biomineral formation GO:0031214 22 16 0,000 0,0892369 0,1175867 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,0892369 0,11752331 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,0892369 0,11745999 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,0892369 0,11739673 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,0892369 0,11733355 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,0892369 0,11727043 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,0892369 0,11720738 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,0892369 0,1171444 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,0892369 0,11708149 ! peptide hormone processing GO:0016486 27 16 0,000 0,0892369 0,11701864 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,08982961 0,11773269 ! regulation of lyase activity GO:0051339 169 86 1,000 0,08982961 0,11766956 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,08982961 0,1176065 GO:0002696|positive regulation of leukocyte activation, ! nucleosome assembly GO:0006334 126 87 1,000 0,0916039 0,1198652 ! chromatin assembly GO:0031497 128 88 1,000 0,09338845 0,1221349 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,09454336 0,12357914 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,09454336 0,12351306 ! endothelial cell migration GO:0043542 31 17 0,000 0,09454336 0,12344704 ! gene silencing by RNA GO:0031047 38 17 0,000 0,09454336 0,1233811 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,09454336 0,12331523 ! glial cell development GO:0021782 28 17 0,000 0,09454336 0,12324942 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,09454336 0,12318369 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,09454336 0,12311803 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,09454336 0,12305244 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,09454336 0,12298691 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,09454336 0,12292146 ! myoblast differentiation GO:0045445 50 17 0,000 0,09454336 0,12285607 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,09454336 0,12279076 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,09454336 0,12272552 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,09454336 0,12266034 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,09454336 0,12259523 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,09454336 0,1225302 ! NAD metabolic process GO:0019674 33 17 0,000 0,09454336 0,12246523 ! membrane budding GO:0006900 42 17 0,000 0,09454336 0,12240033 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,09454336 0,1223355 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,09454336 0,12227074 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,09454336 0,12220604 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,09454336 0,12214142 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,09454336 0,12207686 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,09454336 0,12201237 ! steroid catabolic process GO:0006706 34 17 0,000 0,09454336 0,12194795 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,09454336 0,1218836 ! gas transport GO:0015669 26 17 0,000 0,09454336 0,12181931 ! organic cation transport GO:0015695 32 17 0,000 0,09454336 0,1217551 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,09454336 0,12169095 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,09454336 0,12162687 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,09518308 0,1223854 ! response to inorganic substance GO:0010035 173 90 1,000 0,09698761 0,12464004 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,09880186 0,1269048 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 1,000 0,09880186 0,12683812 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,09981905 0,12807665 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,09981905 0,12800942 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,09981905 0,12794225 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,09981905 0,12787516 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,09981905 0,12780814 ! adult walking behavior GO:0007628 36 18 0,000 0,09981905 0,12774119 ! patterning of blood vessels GO:0001569 43 18 0,000 0,09981905 0,12767431 ! heart looping GO:0001947 34 18 0,000 0,09981905 0,1276075 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,09981905 0,12754076 ! centrosome cycle GO:0007098 26 18 0,000 0,09981905 0,12747409 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,09981905 0,12740749 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,09981905 0,12734096 ! glutamine metabolic process GO:0006541 29 18 0,000 0,09981905 0,1272745 ! response to retinoic acid GO:0032526 31 18 0,000 0,09981905 0,12720811 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 0,000 0,09981905 0,12714178 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,09981905 0,12707553 ! DNA integration GO:0015074 32 18 0,000 0,09981905 0,12700934 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,09981905 0,12694323 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,09981905 0,12687718 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,09981905 0,1268112 ! neural crest cell migration GO:0001755 41 18 0,000 0,09981905 0,12674529 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,09981905 0,12667945 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,09981905 0,12661367 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,09981905 0,12654797 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,09981905 0,12648233 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,09981905 0,12641676 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,09981905 0,12635126 ! detection of bacterium GO:0016045 22 18 0,000 0,09981905 0,12628583 ! nerve development GO:0021675 34 18 0,000 0,09981905 0,12622046 ! bone development GO:0060348 206 92 1,000 0,10062566 0,12717459 ! protein-DNA complex assembly GO:0065004 134 92 1,000 0,10062566 0,12710883 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,10245884 0,12935759 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 1,000 0,10245884 0,12929078 ! nitrogen compound catabolic process GO:0044270 167 94 1,000 0,10430123 0,1315477 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,10430123 0,13147983 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,10506415 0,13237324 ! positive regulation of translation GO:0045727 31 19 0,000 0,10506415 0,13230501 ! negative regulation of defense response GO:0031348 27 19 0,000 0,10506415 0,13223685 ! neuron maturation GO:0042551 46 19 0,000 0,10506415 0,13216875 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,10506415 0,13210073 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,10506415 0,13203278 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,10506415 0,13196489 GO:0019692|deoxyribose phosphate metabolic process, ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,10506415 0,13189708 ! inositol metabolic process GO:0006020 33 19 0,000 0,10506415 0,13182934 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,10506415 0,13176166 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,10506415 0,13169406 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,10506415 0,13162652 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,10506415 0,13155906 ! response to vitamin A GO:0033189 32 19 0,000 0,10506415 0,13149166 ! heme metabolic process GO:0042168 40 19 0,000 0,10506415 0,13142433 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,10506415 0,13135707 ! response to fungus GO:0009620 26 19 0,000 0,10506415 0,13128988 ! peptide cross-linking GO:0018149 39 19 0,000 0,10506415 0,13122276 ! protein export from nucleus GO:0006611 40 19 0,000 0,10506415 0,13115571 ! heart process GO:0003015 32 19 0,000 0,10506415 0,13108872 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,10506415 0,13102181 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,10506415 0,13095496 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,10506415 0,13088818 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,10506415 0,13082147 ! vitamin transport GO:0051180 31 19 0,000 0,10506415 0,13075482 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,10506415 0,13068825 ! cilium assembly GO:0042384 38 19 0,000 0,10506415 0,13062174 ! peptide hormone secretion GO:0030072 32 19 0,000 0,10506415 0,1305553 ! nucleosome organization GO:0034728 143 95 1,000 0,10615266 0,13184085 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,10615266 0,13177386 ! cofactor biosynthetic process GO:0051188 161 95 1,000 0,10615266 0,13170693 ! response to protein stimulus GO:0051789 158 96 1,000 0,10801297 0,13394705 ! protein secretion GO:0009306 45 20 0,000 0,11027884 0,13668757 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,11027884 0,13661825 ! positive regulation of ossification GO:0045778 50 20 0,000 0,11027884 0,13654901 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,11027884 0,13647984 ! skin development GO:0043588 42 20 0,000 0,11027884 0,13641073 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,11027884 0,1363417 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,11027884 0,13627273 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,11027884 0,13620384 ! response to vitamin GO:0033273 36 20 0,000 0,11027884 0,13613502 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,11027884 0,13606626 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,11027884 0,13599758 GO:0010675|regulation of cellular carbohydrate metabolic process, ! bile acid metabolic process GO:0008206 34 20 0,000 0,11027884 0,13592896 ! retinoid metabolic process GO:0001523 34 20 0,000 0,11027884 0,13586041 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,11027884 0,13579193 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,11027884 0,13572352 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,11027884 0,13565518 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,11027884 0,13558691 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,11027884 0,13551871 ! peptide secretion GO:0002790 38 20 0,000 0,11027884 0,13545058 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,11027884 0,13538251 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,11027884 0,13531451 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,11027884 0,13524658 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,11027884 0,13517872 GO:0006626|protein targeting to mitochondrion, ! cell-cell junction organization GO:0045216 43 20 0,000 0,11027884 0,13511093 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,11027884 0,13504321 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,11027884 0,13497555 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,11027884 0,13490796 ! negative regulation of translation GO:0017148 32 20 0,000 0,11027884 0,13484044 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,11175956 0,13658259 ! regulation of cell killing GO:0031341 46 21 0,000 0,11546328 0,1410384 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,11546328 0,14096792 ! hormone secretion GO:0046879 39 21 0,000 0,11546328 0,1408975 ! cAMP metabolic process GO:0046058 41 21 0,000 0,11546328 0,14082716 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,11546328 0,14075689 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,11546328 0,14068668 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,11546328 0,14061655 ! smooth muscle contraction GO:0006939 48 21 0,000 0,11546328 0,14054649 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 0,000 0,11546328 0,14047649 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,11546328 0,14040657 ! plasma membrane fusion GO:0045026 33 21 0,000 0,11546328 0,14033672 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,11546328 0,14026693 ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,11546328 0,14019722 ! sensory perception of pain GO:0019233 33 21 0,000 0,11546328 0,14012757 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,11546328 0,14005799 ! diencephalon development GO:0021536 36 21 0,000 0,11546328 0,13998849 ! collagen fibril organization GO:0030199 62 21 0,000 0,11546328 0,13991905 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,11546328 0,13984968 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,11546328 0,13978038 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,11546328 0,13971114 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,11546328 0,13964198 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,11546328 0,13957288 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,11546328 0,13950386 ! sperm-egg recognition GO:0035036 23 21 0,000 0,11546328 0,1394349 ! actin filament-based movement GO:0030048 47 21 0,000 0,11546328 0,13936601 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,11546328 0,13929719 ! hormone metabolic process GO:0042445 171 100 1,000 0,11553968 0,13932056 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,12061766 0,14537196 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,12061766 0,14530027 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,12061766 0,14522866 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,12061766 0,14515712 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,12061766 0,14508565 ! microtubule-based transport GO:0010970 59 22 0,000 0,12061766 0,14501425 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,12061766 0,14494292 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,12061766 0,14487166 ! cellular response to starvation GO:0009267 37 22 0,000 0,12061766 0,14480047 ! vacuolar transport GO:0007034 41 22 0,000 0,12061766 0,14472935 ! central nervous system neuron development GO:0021954 47 22 0,000 0,12061766 0,1446583 ! fucose metabolic process GO:0006004 44 22 0,000 0,12061766 0,14458732 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,12061766 0,14451641 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,12061766 0,14444557 ! stem cell differentiation GO:0048863 57 22 0,000 0,12061766 0,14437479 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,12061766 0,14430409 ! cytolysis GO:0019835 27 22 0,000 0,12061766 0,14423346 ! vasodilation GO:0042311 40 22 0,000 0,12061766 0,14416289 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,12061766 0,1440924 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,12061766 0,14402197 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,12061766 0,14395161 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,12061766 0,14388133 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,12061766 0,14381111 ! sarcomere organization GO:0045214 32 22 0,000 0,12061766 0,14374095 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,12061766 0,14367087 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,12061766 0,14360085 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,12061766 0,14353091 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,12574215 0,14955603 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,12574215 0,14948325 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,12574215 0,14941055 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,12574215 0,14933791 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,12574215 0,14926535 ! axis specification GO:0009798 43 23 0,000 0,12574215 0,14919285 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,12574215 0,14912043 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,12574215 0,14904808 ! peroxisome organization GO:0007031 43 23 0,000 0,12574215 0,14897579 ! lysosome organization GO:0007040 47 23 0,000 0,12574215 0,14890358 ! vesicle targeting GO:0006903 49 23 0,000 0,12574215 0,14883144 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,12574215 0,14875936 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,12574215 0,14868736 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,12574215 0,14861543 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,12574215 0,14854356 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,12574215 0,14847177 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,12574215 0,14840004 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,12574215 0,14832838 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,12574215 0,1482568 ! hormone transport GO:0009914 41 23 0,000 0,12574215 0,14818528 ! cell-cell recognition GO:0009988 28 23 0,000 0,12574215 0,14811383 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,12574215 0,14804245 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,12574215 0,14797114 GO:0006099|tricarboxylic acid cycle, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,13083693 0,15389245 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,13083693 0,15381839 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,13083693 0,1537444 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,13083693 0,15367049 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,13083693 0,15359664 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,13083693 0,15352287 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,13083693 0,15344916 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,13083693 0,15337553 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,13083693 0,15330197 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,13083693 0,15322848 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,13083693 0,15315506 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,13083693 0,15308171 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,13083693 0,15300843 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,13083693 0,15293522 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,13083693 0,15286208 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,13083693 0,15278901 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,13083693 0,15271601 ! platelet activation GO:0030168 41 24 0,000 0,13083693 0,15264308 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,13083693 0,15257022 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,13083693 0,15249743 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,13083693 0,15242471 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,13083693 0,15235205 ! regulation of amine transport GO:0051952 41 24 0,000 0,13083693 0,15227947 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,13590215 0,1580995 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,13590215 0,15802425 ! phototransduction GO:0007602 37 25 0,000 0,13590215 0,15794907 ! keratinization GO:0031424 37 25 0,000 0,13590215 0,15787397 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,13590215 0,15779893 ! vacuole organization GO:0007033 49 25 0,000 0,13590215 0,15772397 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,13590215 0,15764908 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,13590215 0,15757425 ! chromosome condensation GO:0030261 48 25 0,000 0,13590215 0,1574995 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,13590215 0,15742482 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,13590215 0,15735021 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,13590215 0,15727568 ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,13590215 0,15720121 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,13590215 0,15712681 ! liver development GO:0001889 55 25 0,000 0,13590215 0,15705248 ! protein tetramerization GO:0051262 57 25 0,000 0,13590215 0,15697823 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,140938 0,16271811 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,140938 0,16264125 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,140938 0,16256446 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,140938 0,16248774 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,140938 0,1624111 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,140938 0,16233452 ! digestive system process GO:0022600 49 26 0,000 0,140938 0,16225802 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,140938 0,1621816 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,140938 0,16210524 ! osteoblast differentiation GO:0001649 63 26 0,000 0,140938 0,16202895 ! neural crest cell development GO:0014032 59 26 0,000 0,140938 0,16195274 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,140938 0,1618766 ! negative regulation of cell development GO:0010721 83 26 0,000 0,140938 0,16180053 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,140938 0,16172453 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,140938 0,1616486 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,140938 0,16157275 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,140938 0,16149696 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,140938 0,16142125 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,140938 0,16134561 ! telomere organization GO:0032200 46 26 0,000 0,140938 0,16127004 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,140938 0,16119454 ! neural tube closure GO:0001843 58 26 0,000 0,140938 0,16111911 GO:0060606|tube closure, ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,140938 0,16104375 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,140938 0,16096846 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,14594464 0,16660876 ! embryonic pattern specification GO:0009880 49 27 0,000 0,14594464 0,16653094 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,14594464 0,1664532 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,14594464 0,16637552 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,14594464 0,16629792 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,14594464 0,1662204 ! iron ion transport GO:0006826 65 27 0,000 0,14594464 0,16614294 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,14594464 0,16606556 ! superoxide metabolic process GO:0006801 41 27 0,000 0,14594464 0,16598824 ! tube lumen formation GO:0035148 59 27 0,000 0,14594464 0,165911 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,14594464 0,16583384 ! response to starvation GO:0042594 47 27 0,000 0,14594464 0,16575674 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,14594464 0,16567972 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,14594464 0,16560276 ! neuron fate commitment GO:0048663 52 28 0,000 0,15092224 0,17117132 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,15092224 0,17109189 ! vesicle docking GO:0048278 55 28 0,000 0,15092224 0,17101254 ! circadian rhythm GO:0007623 56 28 0,000 0,15092224 0,17093325 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,15092224 0,17085404 ! sperm motility GO:0030317 37 28 0,000 0,15092224 0,17077491 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,15092224 0,17069585 ! base-excision repair GO:0006284 41 28 0,000 0,15092224 0,17061686 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,15092224 0,17053794 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,15092224 0,1704591 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,15092224 0,17038033 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,15092224 0,17030163 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,15092224 0,170223 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,15092224 0,17014445 ! glutathione metabolic process GO:0006749 42 28 0,000 0,15092224 0,17006597 ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,15092224 0,16998756 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,15092224 0,16990923 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,15587097 0,17539971 ! translational initiation GO:0006413 66 29 0,000 0,15587097 0,17531896 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,15587097 0,17523828 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! autophagy GO:0006914 47 29 0,000 0,15587097 0,17515767 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,15587097 0,17507714 ! primary neural tube formation GO:0014020 61 29 0,000 0,15587097 0,17499668 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,15587097 0,1749163 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,15587097 0,17483599 ! synaptogenesis GO:0007416 46 29 0,000 0,15587097 0,17475575 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,15587097 0,17467559 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,15587097 0,1745955 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,15587097 0,17451548 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,16079099 0,17994155 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,16079099 0,17985916 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,16079099 0,17977684 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,16079099 0,1796946 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,16079099 0,17961244 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,16079099 0,17953035 ! acute-phase response GO:0006953 50 30 0,000 0,16079099 0,17944833 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,16079099 0,17936639 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,16079099 0,17928453 ! myofibril assembly GO:0030239 50 30 0,000 0,16079099 0,17920274 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,16079099 0,17912102 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,16079099 0,17903938 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,16079099 0,17895781 ! cell fate determination GO:0001709 64 30 0,000 0,16079099 0,17887632 ! phospholipid transport GO:0015914 65 30 0,000 0,16079099 0,1787949 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,16079099 0,17871356 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,16079099 0,17863229 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,16079099 0,17855109 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,16568248 0,18389927 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,16568248 0,18381576 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,16568248 0,18373232 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,16568248 0,18364896 ! regulation of innate immune response GO:0045088 57 31 0,000 0,16568248 0,18356567 ! peptide transport GO:0015833 60 31 0,000 0,16568248 0,18348246 ! detection of light stimulus GO:0009583 44 31 0,000 0,16568248 0,18339932 ! natural killer cell activation GO:0030101 50 31 0,000 0,16568248 0,18331626 ! cofactor catabolic process GO:0051187 54 31 0,000 0,16568248 0,18323327 ! eye morphogenesis GO:0048592 65 31 0,000 0,16568248 0,18315036 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,16568248 0,18306753 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,17054559 0,18835573 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,17054559 0,18827062 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,17054559 0,18818559 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,17054559 0,18810063 ! muscle cell development GO:0055001 52 32 0,000 0,17054559 0,18801574 ! mesoderm formation GO:0001707 73 32 0,000 0,17054559 0,18793094 ! BMP signaling pathway GO:0030509 71 32 0,000 0,17054559 0,18784621 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,17054559 0,18776155 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,17054559 0,18767698 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,17054559 0,18759247 ! gene silencing GO:0016458 71 32 0,000 0,17054559 0,18750805 ! regulation of pH GO:0006885 56 33 0,000 0,1753805 0,19273709 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,1753805 0,19265043 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,1753805 0,19256384 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,1753805 0,19247734 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,1753805 0,19239091 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,1753805 0,19230456 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,1753805 0,19221828 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,1753805 0,19213209 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,1753805 0,19204597 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,1753805 0,19195992 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,1753805 0,19187396 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,1753805 0,19178807 ! glial cell differentiation GO:0010001 67 34 0,000 0,18018735 0,19695647 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,18018735 0,19686838 ! cholesterol transport GO:0030301 62 34 0,000 0,18018735 0,19678038 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,18018735 0,19669245 ! spliceosome assembly GO:0000245 75 34 0,000 0,18018735 0,1966046 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,18018735 0,19651683 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,18018735 0,19642914 ! formation of primary germ layer GO:0001704 76 34 0,000 0,18018735 0,19634153 ! adult locomotory behavior GO:0008344 62 34 0,000 0,18018735 0,19625399 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,18496632 0,20136931 ! negative regulation of secretion GO:0051048 68 35 0,000 0,18496632 0,20127961 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,18496632 0,20118999 ! membrane docking GO:0022406 69 35 0,000 0,18496632 0,20110046 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,18496632 0,201011 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,18496632 0,20092162 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,18496632 0,20083232 ! ceramide metabolic process GO:0006672 72 35 0,000 0,18496632 0,2007431 ! sterol transport GO:0015918 63 35 0,000 0,18496632 0,20065396 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,18496632 0,2005649 ! vesicle localization GO:0051648 70 35 0,000 0,18496632 0,20047592 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,18971757 0,20553437 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,18971757 0,20544327 ! protein targeting to membrane GO:0006612 75 36 0,000 0,18971757 0,20535224 ! regulation of proteolysis GO:0030162 77 36 0,000 0,18971757 0,2052613 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,18971757 0,20517044 ! aerobic respiration GO:0009060 56 36 0,000 0,18971757 0,20507965 ! cytokine production GO:0001816 68 36 0,000 0,18971757 0,20498895 ! embryonic organ development GO:0048568 67 36 0,000 0,18971757 0,20489833 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,18971757 0,20480778 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,19444125 0,20981447 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,19444125 0,20972184 ! actomyosin structure organization GO:0031032 68 37 0,000 0,19444125 0,20962929 ! tissue remodeling GO:0048771 78 37 0,000 0,19444125 0,20953682 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,19444125 0,20944443 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,19913752 0,21440854 ! organic anion transport GO:0015711 82 38 0,000 0,19913752 0,21431408 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,19913752 0,21421971 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,19913752 0,21412543 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,19913752 0,21403122 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,19913752 0,2139371 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,19913752 0,21384306 ! spermatid development GO:0007286 69 38 0,000 0,19913752 0,21374911 ! neural tube formation GO:0001841 79 38 0,000 0,19913752 0,21365523 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,20380655 0,21856866 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,20380655 0,21847275 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,20380655 0,21837693 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,20380655 0,2182812 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,20380655 0,21818554 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,20844849 0,22305723 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,20844849 0,22295957 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,20844849 0,222862 ! RNA export from nucleus GO:0006405 61 41 0,000 0,2130635 0,22769647 ! mRNA catabolic process GO:0006402 79 41 0,000 0,2130635 0,22759691 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,2130635 0,22749743 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,2130635 0,22739804 ! gliogenesis GO:0042063 91 41 0,000 0,2130635 0,22729874 ! feeding behavior GO:0007631 69 41 0,000 0,2130635 0,22719953 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,2130635 0,2271004 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,2130635 0,22700136 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,2130635 0,22690241 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,2130635 0,22680354 ! RNA modification GO:0009451 64 41 0,000 0,2130635 0,22670476 ! organic ether metabolic process GO:0018904 59 42 0,000 0,21765172 0,23148592 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,21765172 0,23138519 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,21765172 0,23128454 ! regulation of protein secretion GO:0050708 77 42 0,000 0,21765172 0,23118398 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,21765172 0,23108351 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,22221333 0,23582414 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,22221333 0,23572174 ! regulation of tube size GO:0035150 76 43 0,000 0,22221333 0,23561943 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,22221333 0,23551721 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,22221333 0,23541508 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,22221333 0,23531303 ! ion transmembrane transport GO:0034220 79 43 0,000 0,22221333 0,23521108 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,22674846 0,23990754 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,22674846 0,23980368 ! striated muscle contraction GO:0006941 85 44 0,000 0,22674846 0,23969991 ! phagocytosis GO:0006909 105 44 0,000 0,22674846 0,23959624 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,23125728 0,24425488 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,23125728 0,24414933 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,23125728 0,24404386 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,23125728 0,24393849 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,23125728 0,24383321 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,23573994 0,2484524 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,23573994 0,24834526 ! glycolysis GO:0006096 71 46 0,000 0,23573994 0,24823822 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,23573994 0,24813127 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,23573994 0,2480244 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,23573994 0,24791764 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,24019658 0,2524958 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,24462736 0,25704285 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,24462736 0,25693234 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,24462736 0,25682193 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,24462736 0,25671161 ! response to calcium ion GO:0051592 94 49 0,000 0,24903242 0,26122207 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,24903242 0,26110996 ! JNK cascade GO:0007254 106 49 0,000 0,24903242 0,26099794 ! regulation of ion transport GO:0043269 86 50 0,000 0,25341192 0,26547398 ! endocrine system development GO:0035270 109 50 0,000 0,25341192 0,26536019 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,25341192 0,26524649 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,25341192 0,2651329 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,25341192 0,2650194 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,25341192 0,264906 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,25341192 0,26479269 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,257766 0,26922716 ! peptide metabolic process GO:0006518 80 51 0,000 0,257766 0,26911211 ! Notch signaling pathway GO:0007219 111 52 0,000 0,26209481 0,27351457 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,26209481 0,27339779 ! excretion GO:0007588 87 52 0,000 0,26209481 0,2732811 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,26209481 0,27316451 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,26209481 0,27304802 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,26209481 0,27293164 ! amino acid activation GO:0043038 98 52 0,000 0,26209481 0,27281535 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,26639849 0,27717697 ! chromatin remodeling GO:0006338 122 53 0,000 0,26639849 0,27705897 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,26639849 0,27694107 ! regulation of translational initiation GO:0006446 87 54 0,000 0,2706772 0,28126941 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,2706772 0,28114983 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,2706772 0,28103034 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,2706772 0,28091096 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,2706772 0,28079167 ! regulation of cell shape GO:0008360 142 54 0,000 0,2706772 0,28067249 ! RNA catabolic process GO:0006401 103 55 0,000 0,27493107 0,28496249 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,27493107 0,28484164 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,27493107 0,2847209 ! cell recognition GO:0008037 98 55 0,000 0,27493107 0,28460025 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,27493107 0,28447971 ! glucose catabolic process GO:0006007 88 56 0,000 0,27916024 0,28873348 ! RNA elongation GO:0006354 90 56 0,000 0,27916024 0,28861129 ! chloride transport GO:0006821 102 57 0,000 0,28336487 0,29283434 ! heart morphogenesis GO:0003007 105 57 0,000 0,28336487 0,29271052 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,28336487 0,29258681 ! regulation of actin filament length GO:0030832 118 58 0,000 0,28754509 0,29677763 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,28754509 0,29665231 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,28754509 0,29652708 ! gastrulation GO:0007369 122 58 0,000 0,28754509 0,29640197 ! nuclear export GO:0051168 110 59 0,000 0,29170105 0,30055911 ! regulation of endocytosis GO:0030100 104 60 0,000 0,29583287 0,3046879 ! adult behavior GO:0030534 104 60 0,000 0,29583287 0,30455951 ! positive regulation of secretion GO:0051047 110 61 0,000 0,29994071 0,30865845 ! regulation of cellular component size GO:0032535 125 61 0,000 0,29994071 0,30852849 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,29994071 0,30839864 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,29994071 0,30826889 ! camera-type eye development GO:0043010 126 61 0,000 0,29994071 0,30813926 ! proton transport GO:0015992 117 61 0,000 0,29994071 0,30800974 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,3040247 0,31207242 ! tRNA processing GO:0008033 102 62 0,000 0,3040247 0,31194135 ! mesoderm development GO:0007498 128 63 0,000 0,30808498 0,31597465 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,30808498 0,31584206 ! hydrogen transport GO:0006818 121 64 0,000 0,31212169 0,31984618 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,31212169 0,31971207 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,31613496 0,32368722 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,31613496 0,32355162 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,31613496 0,32341613 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,32012493 0,32736091 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,32409173 0,3312787 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,32409173 0,33114015 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,3280355 0,33502956 ! hexose catabolic process GO:0019320 113 68 0,000 0,3280355 0,33488956 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,3280355 0,33474967 ! adaptive immune response GO:0002250 126 68 0,000 0,3280355 0,3346099 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,33195636 0,33846803 ! single fertilization GO:0007338 83 69 0,000 0,33195636 0,33832682 ! cell redox homeostasis GO:0045454 114 70 0,000 0,33585446 0,34215698 ! activation of immune response GO:0002253 120 70 0,000 0,33585446 0,34201436 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,33585446 0,34187185 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,33972992 0,34567272 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,34358288 0,34944753 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,34358288 0,34930211 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,34741346 0,35304953 ! regulation of immune effector process GO:0002697 156 73 0,000 0,34741346 0,35290274 ! acute inflammatory response GO:0002526 118 74 0,000 0,35122179 0,35662296 ! transition metal ion transport GO:0000041 143 75 0,000 0,35500801 0,36031764 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,35500801 0,36016801 ! eye development GO:0001654 155 75 0,000 0,35500801 0,3600185 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,35877224 0,36368488 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,35877224 0,36353404 ! neurotransmitter transport GO:0006836 142 77 0,000 0,3625146 0,36717378 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,3625146 0,36702162 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,3625146 0,36686958 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,36623523 0,37048143 ! antigen processing and presentation GO:0019882 117 78 0,000 0,36623523 0,37032809 ! fertilization GO:0009566 99 78 0,000 0,36623523 0,37017487 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,36993424 0,37375904 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,36993424 0,37360453 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,37361177 0,37716263 ! protein import into nucleus GO:0006606 174 82 0,000 0,38090287 0,38436419 ! exocytosis GO:0006887 153 83 0,000 0,38451669 0,38785065 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,38451669 0,38769058 ! nuclear import GO:0051170 177 83 0,000 0,38451669 0,38753064 ! inorganic anion transport GO:0015698 156 83 0,000 0,38451669 0,38737083 ! digestion GO:0007586 130 84 0,000 0,38810951 0,39082915 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,39168146 0,39426362 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,39876322 0,40122675 ! alcohol catabolic process GO:0046164 142 87 0,000 0,39876322 0,40106157 ! cellular respiration GO:0045333 143 88 0,000 0,40227328 0,40442536 ! sensory perception of smell GO:0007608 117 88 0,000 0,40227328 0,40425899 ! cellular defense response GO:0006968 123 89 0,000 0,40576294 0,40759821 ! protein localization in nucleus GO:0034504 192 89 0,000 0,40576294 0,40743069 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,40923232 0,41074551 ! response to unfolded protein GO:0006986 139 90 0,000 0,40923232 0,41057682 ! defense response to bacterium GO:0042742 112 91 0,000 0,41268155 0,41386742 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,41952 0,42055287 ! vitamin metabolic process GO:0006766 153 93 0,000 0,41952 0,42038037 ! sterol metabolic process GO:0016125 166 94 0,000 0,42290945 0,42360302 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,4262792 0,42680331 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,4262792 0,42662847 ! mRNA transport GO:0051028 185 100 0,000 0,44283649 0,44301783 ! positive regulation of immune response GO:0050778 175 100 0,000 0,44283649 0,44283649