pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6608-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! urogenital system development GO:0001655 149 69 7,000 3,21E-09 7,843E-06 ! negative regulation of translation GO:0017148 32 20 4,000 5,555E-08 6,786E-05 ! positive regulation of inflammatory response GO:0050729 41 21 4,000 7,26E-08 5,912E-05 ! branching morphogenesis of a tube GO:0048754 102 45 5,000 1,344E-07 8,207E-05 ! negative regulation of phosphorylation GO:0042326 52 24 4,000 1,497E-07 7,315E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 1,539E-07 6,265E-05 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 4,000 2,297E-07 8,018E-05 GO:0045936|negative regulation of phosphate metabolic process, ! morphogenesis of a branching structure GO:0001763 116 52 5,000 3,258E-07 9,949E-05 ! cartilage development GO:0051216 99 53 5,000 3,658E-07 9,929E-05 ! regulation of cell cycle process GO:0010564 161 90 6,000 5,153E-07 1,259E-04 ! gland development GO:0048732 220 91 6,000 5,557E-07 1,234E-04 ! metanephros development GO:0001656 81 32 4,000 6,855E-07 1,396E-04 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 3,000 7,126E-07 1,339E-04 GO:0060675|ureteric bud morphogenesis, ! kidney development GO:0001822 133 60 5,000 7,737E-07 1,35E-04 ! forebrain development GO:0030900 210 98 6,000 9,209E-07 1,5E-04 ! mitotic sister chromatid segregation GO:0000070 63 36 4,000 1,262E-06 1,926E-04 ! stem cell division GO:0017145 11 5 2,000 1,422E-06 2,043E-04 GO:0048103|somatic stem cell division, ! sister chromatid segregation GO:0000819 65 37 4,000 1,453E-06 1,971E-04 ! neutrophil chemotaxis GO:0030593 29 17 3,000 1,674E-06 2,152E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 5,000 1,781E-06 2,176E-04 ! negative regulation of kinase activity GO:0033673 145 70 5,000 1,94E-06 2,257E-04 ! negative regulation of transferase activity GO:0051348 155 74 5,000 2,693E-06 2,991E-04 ! phosphoinositide-mediated signaling GO:0048015 141 75 5,000 2,915E-06 3,096E-04 ! apoptotic mitochondrial changes GO:0008637 42 20 3,000 3,365E-06 3,425E-04 ! positive regulation of response to external stimulus GO:0032103 88 44 4,000 3,513E-06 3,432E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 3,935E-06 3,697E-04 ! collagen fibril organization GO:0030199 62 21 3,000 4,14E-06 3,746E-04 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 5,000 4,256E-06 3,714E-04 ! pigmentation GO:0043473 103 46 4,000 4,396E-06 3,703E-04 ! prostate gland development GO:0030850 14 7 2,000 4,938E-06 4,021E-04 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 2,000 4,938E-06 3,892E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 4,938E-06 3,77E-04 ! central nervous system neuron development GO:0021954 47 22 3,000 5,039E-06 3,73E-04 ! ureteric bud development GO:0001657 50 22 3,000 5,039E-06 3,621E-04 ! positive regulation of cell cycle GO:0045787 96 48 4,000 5,445E-06 3,8E-04 ! positive regulation of defense response GO:0031349 88 48 4,000 5,445E-06 3,695E-04 ! regulation of inflammatory response GO:0050727 84 48 4,000 5,445E-06 3,595E-04 ! regulation of ossification GO:0030278 123 50 4,000 6,68E-06 4,294E-04 ! central nervous system neuron differentiation GO:0021953 51 24 3,000 7,26E-06 4,548E-04 ! negative regulation of immune system process GO:0002683 101 51 4,000 7,375E-06 4,504E-04 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 2,000 7,871E-06 4,69E-04 ! regulation of pigmentation during development GO:0048070 25 8 2,000 7,871E-06 4,578E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 7,871E-06 4,472E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 7,871E-06 4,37E-04 ! dendrite morphogenesis GO:0048813 14 8 2,000 7,871E-06 4,273E-04 ! tube morphogenesis GO:0035239 194 89 5,000 7,915E-06 4,204E-04 ! axon extension GO:0048675 16 9 2,000 1,176E-05 6,113E-04 ! induction of positive chemotaxis GO:0050930 17 9 2,000 1,176E-05 5,985E-04 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 1,184E-05 5,905E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 4,000 1,281E-05 6,261E-04 ! regulation of bone remodeling GO:0046850 143 57 4,000 1,281E-05 6,138E-04 ! dendrite development GO:0016358 67 28 3,000 1,376E-05 6,465E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 5,000 1,379E-05 6,355E-04 ! positive regulation of cell migration GO:0030335 137 58 4,000 1,396E-05 6,317E-04 ! aging GO:0007568 112 58 4,000 1,396E-05 6,202E-04 ! regulation of tissue remodeling GO:0034103 146 58 4,000 1,396E-05 6,091E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 1,674E-05 7,173E-04 ! SMAD protein nuclear translocation GO:0007184 21 10 2,000 1,674E-05 7,049E-04 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 1,674E-05 6,929E-04 ! central nervous system neuron axonogenesis GO:0021955 23 10 2,000 1,674E-05 6,814E-04 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 1,674E-05 6,702E-04 ! negative regulation of BMP signaling pathway GO:0030514 19 10 2,000 1,674E-05 6,594E-04 ! cell junction assembly GO:0034329 85 31 3,000 2,089E-05 8,099E-04 ! cellular response to extracellular stimulus GO:0031668 52 31 3,000 2,089E-05 7,973E-04 ! regulation of mitosis GO:0007088 112 63 4,000 2,097E-05 7,881E-04 GO:0051783|regulation of nuclear division, ! response to peptide hormone stimulus GO:0043434 129 64 4,000 2,265E-05 8,383E-04 ! detection of mechanical stimulus GO:0050982 22 11 2,000 2,292E-05 8,358E-04 ! chondrocyte differentiation GO:0002062 27 11 2,000 2,292E-05 8,235E-04 ! negative regulation of glucose import GO:0046325 18 11 2,000 2,292E-05 8,116E-04 GO:0010829|negative regulation of glucose transport, ! spindle organization GO:0007051 50 32 3,000 2,377E-05 8,297E-04 ! positive regulation of cell motion GO:0051272 157 65 4,000 2,443E-05 8,406E-04 ! leukocyte chemotaxis GO:0030595 55 33 3,000 2,694E-05 9,141E-04 GO:0060326|cell chemotaxis, ! negative regulation of cell growth GO:0030308 142 67 4,000 2,832E-05 9,479E-04 ! chromosome segregation GO:0007059 127 67 4,000 2,832E-05 9,351E-04 ! regulation of B cell proliferation GO:0030888 22 12 2,000 3,044E-05 9,916E-04 ! regulation of positive chemotaxis GO:0050926 22 12 2,000 3,044E-05 9,786E-04 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 37 12 2,000 3,044E-05 9,659E-04 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 3,044E-05 9,535E-04 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of cell size GO:0045792 144 69 4,000 3,268E-05 1,011E-03 ! positive regulation of cell development GO:0010720 85 36 3,000 3,831E-05 1,17E-03 ! gland morphogenesis GO:0022612 31 13 2,000 3,942E-05 1,189E-03 ! appendage morphogenesis GO:0035107 150 72 4,000 4,017E-05 1,197E-03 GO:0035108|limb morphogenesis, ! cell junction organization GO:0034330 96 37 3,000 4,277E-05 1,259E-03 ! appendage development GO:0048736 151 73 4,000 4,294E-05 1,249E-03 GO:0060173|limb development, ! regulation of protein stability GO:0031647 77 38 3,000 4,761E-05 1,368E-03 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 4,761E-05 1,352E-03 ! reproductive structure development GO:0048608 131 75 4,000 4,893E-05 1,374E-03 ! hair follicle morphogenesis GO:0031069 27 14 2,000 4,998E-05 1,388E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 4,998E-05 1,372E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 4,998E-05 1,357E-03 ! carbohydrate homeostasis GO:0033500 59 39 3,000 5,283E-05 1,418E-03 GO:0042593|glucose homeostasis, ! regulation of the force of heart contraction GO:0002026 31 15 2,000 6,223E-05 1,653E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 6,223E-05 1,635E-03 ! multicellular organismal metabolic process GO:0044236 64 41 3,000 6,452E-05 1,677E-03 ! mesenchymal cell development GO:0014031 94 41 3,000 6,452E-05 1,659E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of T cell differentiation GO:0045580 78 42 3,000 7,102E-05 1,807E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 7,63E-05 1,922E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! neuron migration GO:0001764 85 43 3,000 7,798E-05 1,944E-03 ! negative regulation of growth GO:0045926 168 85 4,000 8,912E-05 2,199E-03 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 8,912E-05 2,177E-03 ! negative regulation of cell cycle process GO:0010948 35 17 2,000 9,229E-05 2,232E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 9,229E-05 2,21E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 9,338E-05 2,215E-03 ! glycolysis GO:0006096 71 46 3,000 1,019E-04 2,393E-03 ! leukocyte migration GO:0050900 75 46 3,000 1,019E-04 2,37E-03 ! epidermis morphogenesis GO:0048730 43 18 2,000 1,103E-04 2,543E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 1,103E-04 2,519E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 1,103E-04 2,495E-03 ! regulation of BMP signaling pathway GO:0030510 33 18 2,000 1,103E-04 2,473E-03 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 2,000 1,103E-04 2,45E-03 ! response to insulin stimulus GO:0032868 98 47 3,000 1,109E-04 2,44E-03 ! regulation of cell adhesion GO:0030155 241 92 4,000 1,297E-04 2,829E-03 ! pigmentation during development GO:0048066 42 19 2,000 1,305E-04 2,821E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 1,306E-04 2,799E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 1,306E-04 2,775E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 1,365E-04 2,875E-03 ! regulation of action potential GO:0001508 102 50 3,000 1,414E-04 2,953E-03 ! regulation of membrane potential GO:0042391 179 94 4,000 1,436E-04 2,972E-03 ! regulation of defense response GO:0031347 171 95 4,000 1,509E-04 3,098E-03 ! positive regulation of ossification GO:0045778 50 20 2,000 1,529E-04 3,113E-03 ! response to alkaloid GO:0043279 38 20 2,000 1,529E-04 3,088E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 1,529E-04 3,062E-03 ! regulation of glucose import GO:0046324 30 20 2,000 1,529E-04 3,038E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 1,529E-04 3,013E-03 ! positive regulation of growth GO:0045927 96 53 3,000 1,776E-04 3,471E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 1,776E-04 3,443E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 1,777E-04 3,419E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 1,777E-04 3,392E-03 ! collagen catabolic process GO:0030574 29 21 2,000 1,777E-04 3,366E-03 ! activation of phospholipase C activity GO:0007202 110 54 3,000 1,91E-04 3,59E-03 GO:0010863|positive regulation of phospholipase C activity, ! epithelial tube morphogenesis GO:0060562 114 54 3,000 1,91E-04 3,562E-03 ! positive regulation of bone remodeling GO:0046852 54 22 2,000 2,05E-04 3,794E-03 GO:0034105|positive regulation of tissue remodeling, ! glutamate signaling pathway GO:0007215 48 22 2,000 2,05E-04 3,766E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 2,05E-04 3,737E-03 ! cellular response to starvation GO:0009267 37 22 2,000 2,05E-04 3,71E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 2,05E-04 3,682E-03 ! cell aging GO:0007569 48 22 2,000 2,05E-04 3,656E-03 ! renal system process GO:0003014 42 22 2,000 2,05E-04 3,629E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 2,05E-04 3,603E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! response to glucocorticoid stimulus GO:0051384 42 22 2,000 2,05E-04 3,577E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 2,05E-04 3,552E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 2,000 2,05E-04 3,527E-03 ! positive regulation of phospholipase activity GO:0010518 111 55 3,000 2,052E-04 3,505E-03 ! response to UV GO:0009411 120 55 3,000 2,052E-04 3,481E-03 ! glucose catabolic process GO:0006007 88 56 3,000 2,2E-04 3,707E-03 ! positive regulation of DNA replication GO:0045740 44 23 2,000 2,348E-04 3,93E-03 ! regulation of chemotaxis GO:0050920 45 23 2,000 2,348E-04 3,903E-03 ! regulation of cell-matrix adhesion GO:0001952 81 23 2,000 2,348E-04 3,876E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 2,348E-04 3,85E-03 ! regulation of phospholipase activity GO:0010517 113 57 3,000 2,357E-04 3,838E-03 ! heart morphogenesis GO:0003007 105 57 3,000 2,357E-04 3,813E-03 ! positive regulation of lipase activity GO:0060193 115 58 3,000 2,521E-04 4,052E-03 ! positive regulation of cell adhesion GO:0045785 61 24 2,000 2,673E-04 4,269E-03 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 2,673E-04 4,241E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 2,673E-04 4,214E-03 ! response to corticosteroid stimulus GO:0031960 46 24 2,000 2,673E-04 4,187E-03 ! sex determination GO:0007530 48 24 2,000 2,673E-04 4,16E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 2,673E-04 4,134E-03 ! platelet activation GO:0030168 41 24 2,000 2,673E-04 4,108E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 2,725E-04 4,16E-03 GO:0045844|positive regulation of striated muscle development, ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 2,725E-04 4,134E-03 ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 1,000 2,725E-04 4,109E-03 ! protein maturation by protein folding GO:0022417 14 5 1,000 2,725E-04 4,084E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 2,725E-04 4,059E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 2,725E-04 4,034E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 2,725E-04 4,01E-03 ! microvillus organization GO:0032528 8 5 1,000 2,725E-04 3,986E-03 GO:0030033|microvillus assembly, ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 1,000 2,725E-04 3,962E-03 ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 1,000 2,725E-04 3,939E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 2,725E-04 3,915E-03 ! forebrain neuron development GO:0021884 13 5 1,000 2,725E-04 3,893E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 2,725E-04 3,87E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 2,725E-04 3,848E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 2,725E-04 3,825E-03 ! muscle cell proliferation GO:0033002 12 5 1,000 2,725E-04 3,804E-03 ! B cell homeostasis GO:0001782 13 5 1,000 2,725E-04 3,782E-03 ! regulation of hair follicle development GO:0051797 10 5 1,000 2,725E-04 3,761E-03 GO:0042634|regulation of hair cycle, ! glial cell migration GO:0008347 10 5 1,000 2,725E-04 3,739E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 2,725E-04 3,719E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 2,725E-04 3,698E-03 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 1,000 2,725E-04 3,677E-03 ! sequestering of calcium ion GO:0051208 7 5 1,000 2,725E-04 3,657E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 2,725E-04 3,637E-03 ! DNA catabolic process GO:0006308 94 60 3,000 2,874E-04 3,816E-03 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 3,026E-04 3,996E-03 ! keratinization GO:0031424 37 25 2,000 3,026E-04 3,975E-03 ! vasculogenesis GO:0001570 49 25 2,000 3,026E-04 3,954E-03 ! regulation of behavior GO:0050795 48 25 2,000 3,026E-04 3,933E-03 ! regulation of heart contraction GO:0008016 123 61 3,000 3,063E-04 3,959E-03 ! negative regulation of response to stimulus GO:0048585 106 61 3,000 3,063E-04 3,938E-03 ! regulation of homeostatic process GO:0032844 148 62 3,000 3,261E-04 4,171E-03 ! myelination GO:0042552 50 26 2,000 3,408E-04 4,336E-03 ! molting cycle process GO:0022404 52 26 2,000 3,408E-04 4,314E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 3,408E-04 4,291E-03 ! regulation of osteoblast differentiation GO:0045667 68 26 2,000 3,408E-04 4,269E-03 ! skeletal system morphogenesis GO:0048705 118 63 3,000 3,468E-04 4,322E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 3,684E-04 4,568E-03 ! multicellular organismal catabolic process GO:0044243 38 27 2,000 3,819E-04 4,712E-03 ! response to starvation GO:0042594 47 27 2,000 3,819E-04 4,688E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 3,819E-04 4,665E-03 ! cellular response to nutrient levels GO:0031669 45 27 2,000 3,819E-04 4,642E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 3,819E-04 4,619E-03 ! myoblast cell fate commitment GO:0048625 18 6 1,000 4,073E-04 4,901E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 4,073E-04 4,877E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 1,000 4,073E-04 4,854E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! establishment of spindle localization GO:0051293 16 6 1,000 4,073E-04 4,83E-03 GO:0051653|spindle localization, ! neural nucleus development GO:0048857 19 6 1,000 4,073E-04 4,807E-03 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 1,000 4,073E-04 4,784E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 4,073E-04 4,761E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 4,073E-04 4,738E-03 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 1,000 4,073E-04 4,716E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 4,073E-04 4,693E-03 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 1,000 4,073E-04 4,671E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 4,073E-04 4,649E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 4,261E-04 4,841E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 4,261E-04 4,819E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 4,261E-04 4,797E-03 ! embryonic limb morphogenesis GO:0030326 139 67 3,000 4,39E-04 4,919E-03 GO:0035113|embryonic appendage morphogenesis, ! hexose catabolic process GO:0019320 113 68 3,000 4,645E-04 5,182E-03 ! extracellular matrix organization GO:0030198 146 68 3,000 4,645E-04 5,158E-03 ! regulation of lipase activity GO:0060191 137 68 3,000 4,645E-04 5,135E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 3,000 4,911E-04 5,404E-03 ! germ cell development GO:0007281 133 70 3,000 5,187E-04 5,683E-03 ! regulation of B cell activation GO:0050864 55 30 2,000 5,24E-04 5,715E-03 ! cell cycle checkpoint GO:0000075 145 71 3,000 5,475E-04 5,944E-03 ! forebrain neuron differentiation GO:0021879 16 7 1,000 5,682E-04 6,142E-03 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 5,682E-04 6,115E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 5,682E-04 6,088E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 5,682E-04 6,062E-03 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 1,000 5,682E-04 6,035E-03 GO:0031958|corticosteroid receptor signaling pathway, ! neuron remodeling GO:0016322 16 7 1,000 5,682E-04 6,009E-03 ! organ growth GO:0035265 15 7 1,000 5,682E-04 5,983E-03 ! male sex determination GO:0030238 15 7 1,000 5,682E-04 5,958E-03 ! spindle checkpoint GO:0031577 16 7 1,000 5,682E-04 5,932E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 5,682E-04 5,907E-03 ! regulation of meiosis GO:0040020 12 7 1,000 5,682E-04 5,882E-03 GO:0051445|regulation of meiotic cell cycle, ! T cell lineage commitment GO:0002360 16 7 1,000 5,682E-04 5,857E-03 ! negative regulation of nuclear division GO:0051784 15 7 1,000 5,682E-04 5,833E-03 GO:0045839|negative regulation of mitosis, ! peptidyl-threonine modification GO:0018210 26 7 1,000 5,682E-04 5,808E-03 ! dopamine biosynthetic process GO:0042416 18 7 1,000 5,682E-04 5,784E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 5,682E-04 5,76E-03 ! male gonad development GO:0008584 56 31 2,000 5,779E-04 5,834E-03 ! ensheathment of neurons GO:0007272 64 31 2,000 5,779E-04 5,81E-03 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 5,779E-04 5,786E-03 ! collagen metabolic process GO:0032963 49 32 2,000 6,352E-04 6,334E-03 ! response to mechanical stimulus GO:0009612 60 32 2,000 6,352E-04 6,308E-03 ! BMP signaling pathway GO:0030509 71 32 2,000 6,352E-04 6,283E-03 ! hindbrain development GO:0030902 65 32 2,000 6,352E-04 6,257E-03 ! eye development GO:0001654 155 75 3,000 6,737E-04 6,61E-03 ! monosaccharide catabolic process GO:0046365 125 77 3,000 7,44E-04 7,271E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 7,55E-04 7,348E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 7,55E-04 7,319E-03 ! generation of neurons in the forebrain GO:0021872 18 8 1,000 7,55E-04 7,29E-03 ! pigment granule organization GO:0048753 17 8 1,000 7,55E-04 7,262E-03 ! ER overload response GO:0006983 13 8 1,000 7,55E-04 7,233E-03 ! melanin metabolic process GO:0006582 17 8 1,000 7,55E-04 7,205E-03 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 1,000 7,55E-04 7,177E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 7,55E-04 7,149E-03 ! response to UV-B GO:0010224 17 8 1,000 7,55E-04 7,121E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 7,55E-04 7,094E-03 ! positive regulation of epidermis development GO:0045684 13 8 1,000 7,55E-04 7,067E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 1,000 7,55E-04 7,04E-03 ! post-embryonic development GO:0009791 76 34 2,000 7,604E-04 7,064E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 7,604E-04 7,037E-03 ! blood coagulation GO:0007596 151 79 3,000 8,194E-04 7,554E-03 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 3,000 8,194E-04 7,525E-03 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 2,000 8,285E-04 7,581E-03 ! calcium-mediated signaling GO:0019722 67 35 2,000 8,285E-04 7,553E-03 ! negative regulation of organelle organization GO:0010639 181 80 3,000 8,59E-04 7,801E-03 ! response to hypoxia GO:0001666 178 81 3,000 8,999E-04 8,143E-03 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 8,999E-04 8,113E-03 ! cell-substrate adhesion GO:0031589 189 82 3,000 9,422E-04 8,463E-03 ! protein import into nucleus GO:0006606 174 82 3,000 9,422E-04 8,432E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 9,673E-04 8,625E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 9,673E-04 8,594E-03 ! microtubule bundle formation GO:0001578 22 9 1,000 9,673E-04 8,562E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 9,673E-04 8,532E-03 ! T cell selection GO:0045058 27 9 1,000 9,673E-04 8,501E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 9,673E-04 8,47E-03 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 1,000 9,673E-04 8,44E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 9,673E-04 8,41E-03 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 9,673E-04 8,38E-03 ! regulation of telomere maintenance GO:0032204 17 9 1,000 9,673E-04 8,351E-03 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 1,000 9,673E-04 8,321E-03 ! negative regulation of cell activation GO:0050866 69 37 2,000 9,76E-04 8,367E-03 ! response to drug GO:0042493 149 83 3,000 9,859E-04 8,422E-03 ! response to oxygen levels GO:0070482 183 83 3,000 9,859E-04 8,392E-03 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 9,859E-04 8,363E-03 GO:0045937|positive regulation of phosphate metabolic process, ! nuclear import GO:0051170 177 83 3,000 9,859E-04 8,334E-03 ! T cell activation GO:0042110 189 84 3,000 1,031E-03 8,685E-03 ! regulation of ligase activity GO:0051340 147 84 3,000 1,031E-03 8,655E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 1,056E-03 8,832E-03 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 2,000 1,056E-03 8,802E-03 ! embryonic skeletal system morphogenesis GO:0048704 68 38 2,000 1,056E-03 8,772E-03 ! hemostasis GO:0007599 165 85 3,000 1,077E-03 8,923E-03 ! mitotic cell cycle checkpoint GO:0007093 76 39 2,000 1,139E-03 9,402E-03 ! mitochondrion organization GO:0007005 159 87 3,000 1,175E-03 9,664E-03 ! alcohol catabolic process GO:0046164 142 87 3,000 1,175E-03 9,632E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 1,205E-03 9,846E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,205E-03 9,813E-03 ! regulation of phosphatase activity GO:0010921 28 10 1,000 1,205E-03 9,78E-03 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 1,205E-03 9,748E-03 ! positive regulation of heart contraction GO:0045823 17 10 1,000 1,205E-03 9,716E-03 ! B cell proliferation GO:0042100 19 10 1,000 1,205E-03 9,684E-03 ! epithelial cell development GO:0002064 21 10 1,000 1,205E-03 9,652E-03 ! motor axon guidance GO:0008045 22 10 1,000 1,205E-03 9,62E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 1,205E-03 9,589E-03 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,205E-03 9,558E-03 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,205E-03 9,527E-03 ! positive regulation of phagocytosis GO:0050766 14 10 1,000 1,205E-03 9,496E-03 ! salivary gland development GO:0007431 28 10 1,000 1,205E-03 9,466E-03 ! midbrain development GO:0030901 14 10 1,000 1,205E-03 9,435E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,205E-03 9,405E-03 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 1,205E-03 9,375E-03 ! nucleus organization GO:0006997 73 40 2,000 1,227E-03 9,515E-03 ! regulation of action potential in neuron GO:0019228 80 40 2,000 1,227E-03 9,484E-03 ! protein localization in nucleus GO:0034504 192 89 3,000 1,278E-03 9,852E-03 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 2,000 1,319E-03 0,01012977 ! T cell differentiation GO:0030217 93 42 2,000 1,415E-03 0,01083295 ! cortical actin cytoskeleton organization GO:0030866 29 11 1,000 1,468E-03 0,01120485 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,468E-03 0,01116994 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 1,468E-03 0,01113525 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,468E-03 0,01110078 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,468E-03 0,01106652 ! adult heart development GO:0007512 16 11 1,000 1,468E-03 0,01103247 ! behavioral fear response GO:0001662 27 11 1,000 1,468E-03 0,01099863 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 1,468E-03 0,01096499 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,468E-03 0,01093156 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 1,000 1,468E-03 0,01089833 ! DNA methylation GO:0006306 19 11 1,000 1,468E-03 0,01086531 GO:0006305|DNA alkylation, ! thymus development GO:0048538 29 11 1,000 1,468E-03 0,01083248 ! oocyte development GO:0048599 20 11 1,000 1,468E-03 0,01079986 ! cardiac cell differentiation GO:0035051 36 11 1,000 1,468E-03 0,01076742 ! sequestering of metal ion GO:0051238 15 11 1,000 1,468E-03 0,01073519 ! regulation of embryonic development GO:0045995 35 11 1,000 1,468E-03 0,01070314 ! epithelial cell differentiation GO:0030855 83 43 2,000 1,515E-03 0,0110137 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 2,000 1,515E-03 0,01098102 ! development of primary male sexual characteristics GO:0046546 80 43 2,000 1,515E-03 0,01094853 ! regulation of T cell proliferation GO:0042129 80 43 2,000 1,515E-03 0,01091623 ! response to reactive oxygen species GO:0000302 75 44 2,000 1,619E-03 0,01163561 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 2,000 1,619E-03 0,01160149 ! sex differentiation GO:0007548 171 96 3,000 1,69E-03 0,0120747 ! regulation of T cell activation GO:0050863 175 96 3,000 1,69E-03 0,01203949 ! keratinocyte differentiation GO:0030216 81 45 2,000 1,728E-03 0,0122744 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,755E-03 0,01242837 ! cortical cytoskeleton organization GO:0030865 30 12 1,000 1,755E-03 0,01239245 ! virus-host interaction GO:0019048 30 12 1,000 1,755E-03 0,01235674 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 1,755E-03 0,01232123 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 1,000 1,755E-03 0,01228592 ! regulation of phagocytosis GO:0050764 17 12 1,000 1,755E-03 0,01225082 ! histone acetylation GO:0016573 27 12 1,000 1,755E-03 0,01221592 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,755E-03 0,01218122 ! T cell homeostasis GO:0043029 28 12 1,000 1,755E-03 0,01214671 ! oocyte differentiation GO:0009994 21 12 1,000 1,755E-03 0,01211239 ! localization within membrane GO:0051668 26 12 1,000 1,755E-03 0,01207828 ! regulation of DNA metabolic process GO:0051052 188 97 3,000 1,756E-03 0,01204965 ! leukocyte differentiation GO:0002521 232 98 3,000 1,823E-03 0,01247636 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 1,842E-03 0,01256876 ! negative regulation of cell migration GO:0030336 122 46 2,000 1,842E-03 0,01253375 ! cell growth GO:0016049 90 46 2,000 1,842E-03 0,01249894 ! skeletal muscle tissue development GO:0007519 223 100 3,000 1,963E-03 0,01328487 GO:0060538|skeletal muscle organ development, ! positive regulation of cell growth GO:0030307 24 13 1,000 2,067E-03 0,01394993 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,067E-03 0,0139115 ! Golgi organization GO:0007030 25 13 1,000 2,067E-03 0,01387328 ! exocrine system development GO:0035272 34 13 1,000 2,067E-03 0,01383527 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 2,067E-03 0,01379747 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 2,067E-03 0,01375988 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,067E-03 0,01372248 ! regulation of epidermis development GO:0045682 19 13 1,000 2,067E-03 0,0136853 ! spleen development GO:0048536 24 13 1,000 2,067E-03 0,01364831 ! digestive tract morphogenesis GO:0048546 31 13 1,000 2,067E-03 0,01361152 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! insulin secretion GO:0030073 24 13 1,000 2,067E-03 0,01357493 ! cellular component disassembly GO:0022411 89 48 2,000 2,082E-03 0,01363946 ! endosome transport GO:0016197 127 48 2,000 2,082E-03 0,01360299 ! male sex differentiation GO:0046661 93 48 2,000 2,082E-03 0,01356672 ! detection of stimulus involved in sensory perception GO:0050906 75 49 2,000 2,21E-03 0,01435772 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 2,342E-03 0,01517516 ! activation of caspase activity GO:0006919 95 50 2,000 2,342E-03 0,01513502 ! epidermal cell differentiation GO:0009913 87 50 2,000 2,342E-03 0,01509508 ! palate development GO:0060021 32 14 1,000 2,403E-03 0,01545045 ! cell-cell junction assembly GO:0007043 32 14 1,000 2,403E-03 0,01540989 ! fear response GO:0042596 34 14 1,000 2,403E-03 0,01536955 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 2,403E-03 0,01532942 ! response to gamma radiation GO:0010332 30 14 1,000 2,403E-03 0,0152895 ! positive regulation of bone mineralization GO:0030501 32 14 1,000 2,403E-03 0,01524979 ! catecholamine biosynthetic process GO:0042423 30 14 1,000 2,403E-03 0,01521028 ! detection of abiotic stimulus GO:0009582 80 51 2,000 2,479E-03 0,01564669 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 2,763E-03 0,01739958 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 2,763E-03 0,01735485 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 2,763E-03 0,01731035 ! positive regulation of biomineral formation GO:0070169 33 15 1,000 2,763E-03 0,01726608 ! regulation of vasodilation GO:0042312 27 15 1,000 2,763E-03 0,01722203 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 2,763E-03 0,01717821 ! dopamine metabolic process GO:0042417 35 15 1,000 2,763E-03 0,01713461 ! lymphocyte homeostasis GO:0002260 33 15 1,000 2,763E-03 0,01709123 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 2,767E-03 0,01706916 ! embryonic skeletal system development GO:0048706 101 54 2,000 2,918E-03 0,01795856 ! regulation of muscle contraction GO:0006937 94 54 2,000 2,918E-03 0,01791344 ! cell maturation GO:0048469 107 55 2,000 3,075E-03 0,01882695 ! negative regulation of cell motion GO:0051271 142 55 2,000 3,075E-03 0,01877988 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 3,147E-03 0,01917417 ! positive regulation of cell size GO:0045793 29 16 1,000 3,147E-03 0,01912647 ! pituitary gland development GO:0021983 30 16 1,000 3,147E-03 0,01907901 ! regulation of dephosphorylation GO:0035303 43 16 1,000 3,147E-03 0,01903179 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 1,000 3,147E-03 0,01898479 ! negative regulation of immune response GO:0050777 38 16 1,000 3,147E-03 0,01893803 ! embryonic digit morphogenesis GO:0042733 36 16 1,000 3,147E-03 0,0188915 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 3,147E-03 0,0188452 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,147E-03 0,01879912 ! skeletal muscle fiber development GO:0048741 130 56 2,000 3,236E-03 0,01928471 ! regulation of DNA replication GO:0006275 105 56 2,000 3,236E-03 0,01923779 ! positive regulation of caspase activity GO:0043280 108 57 2,000 3,403E-03 0,02017962 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 2,000 3,403E-03 0,02013076 ! metencephalon development GO:0022037 32 17 1,000 3,555E-03 0,02097575 ! myoblast differentiation GO:0045445 50 17 1,000 3,555E-03 0,0209252 ! regulation of survival gene product expression GO:0045884 38 17 1,000 3,555E-03 0,0208749 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 3,555E-03 0,02082484 GO:0031114|regulation of microtubule depolymerization, ! regulation of protein binding GO:0043393 33 17 1,000 3,555E-03 0,02077502 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 3,555E-03 0,02072544 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 1,000 3,985E-03 0,02318039 GO:0050886|endocrine process, ! patterning of blood vessels GO:0001569 43 18 1,000 3,985E-03 0,02312533 ! regulation of viral genome replication GO:0045069 30 18 1,000 3,985E-03 0,02307053 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 1,000 3,985E-03 0,02301599 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 1,000 3,985E-03 0,02296171 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 3,985E-03 0,02290768 ! defense response to virus GO:0051607 43 18 1,000 3,985E-03 0,02285391 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 3,985E-03 0,02280038 ! neuron maturation GO:0042551 46 19 1,000 4,439E-03 0,02533561 ! protein amino acid ADP-ribosylation GO:0006471 37 19 1,000 4,439E-03 0,02527655 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 4,439E-03 0,02521777 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 4,439E-03 0,02515926 ! neuromuscular junction development GO:0007528 43 19 1,000 4,439E-03 0,02510102 ! protein export from nucleus GO:0006611 40 19 1,000 4,439E-03 0,02504305 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 1,000 4,439E-03 0,02498535 ! cellular pigmentation GO:0033059 37 19 1,000 4,439E-03 0,02492791 ! proximal/distal pattern formation GO:0009954 33 19 1,000 4,439E-03 0,02487074 ! peptide hormone secretion GO:0030072 32 19 1,000 4,439E-03 0,02481383 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 4,915E-03 0,02741319 ! protein amino acid acetylation GO:0006473 41 20 1,000 4,915E-03 0,02735075 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 4,915E-03 0,02728859 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 4,915E-03 0,02722671 GO:0010675|regulation of cellular carbohydrate metabolic process, ! actin filament bundle formation GO:0051017 47 20 1,000 4,915E-03 0,02716511 ! peptide secretion GO:0002790 38 20 1,000 4,915E-03 0,02710379 ! cell-cell junction organization GO:0045216 43 20 1,000 4,915E-03 0,02704274 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 2,000 4,927E-03 0,02704783 ! ear development GO:0043583 114 66 2,000 5,142E-03 0,02816418 ! regulation of cytokine biosynthetic process GO:0042035 108 66 2,000 5,142E-03 0,02810117 ! gonad development GO:0008406 115 66 2,000 5,142E-03 0,02803845 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 5,142E-03 0,027976 ! hormone secretion GO:0046879 39 21 1,000 5,413E-03 0,02938926 ! lipid phosphorylation GO:0046834 43 21 1,000 5,413E-03 0,02932409 ! ovarian follicle development GO:0001541 39 21 1,000 5,413E-03 0,02925922 ! plasma membrane fusion GO:0045026 33 21 1,000 5,413E-03 0,02919463 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 5,413E-03 0,02913032 ! regulation of vasoconstriction GO:0019229 40 21 1,000 5,413E-03 0,0290663 ! diencephalon development GO:0021536 36 21 1,000 5,413E-03 0,02900256 ! positive regulation of osteoblast differentiation GO:0045669 52 21 1,000 5,413E-03 0,02893909 ! negative regulation of ligase activity GO:0051352 116 68 2,000 5,588E-03 0,02980784 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 2,000 5,588E-03 0,0297429 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 2,000 5,588E-03 0,02967824 ! lung development GO:0030324 165 69 2,000 5,82E-03 0,03084165 ! developmental maturation GO:0021700 128 69 2,000 5,82E-03 0,03077489 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 1,000 5,934E-03 0,03131231 ! hindlimb morphogenesis GO:0035137 47 22 1,000 5,934E-03 0,03124483 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 5,934E-03 0,03117764 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 5,934E-03 0,03111073 ! positive regulation of B cell activation GO:0050871 42 22 1,000 5,934E-03 0,03104411 ! response to cytokine stimulus GO:0034097 69 22 1,000 5,934E-03 0,03097778 ! gut development GO:0048565 44 22 1,000 5,934E-03 0,03091173 ! protein stabilization GO:0050821 41 22 1,000 5,934E-03 0,03084596 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 6,3E-03 0,03267883 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 1,000 6,477E-03 0,03352476 ! regeneration GO:0031099 42 23 1,000 6,477E-03 0,03345388 ! response to ethanol GO:0045471 47 23 1,000 6,477E-03 0,0333833 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 6,477E-03 0,03331302 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 6,477E-03 0,03324304 ! DNA modification GO:0006304 36 23 1,000 6,477E-03 0,03317335 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 6,477E-03 0,03310394 ! regulation of bone mineralization GO:0030500 54 23 1,000 6,477E-03 0,03303483 ! hormone transport GO:0009914 41 23 1,000 6,477E-03 0,03296601 ! acetyl-CoA catabolic process GO:0046356 37 23 1,000 6,477E-03 0,03289748 GO:0006099|tricarboxylic acid cycle, ! respiratory tube development GO:0030323 171 72 2,000 6,549E-03 0,03319422 ! actin filament organization GO:0007015 167 72 2,000 6,549E-03 0,03312549 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 2,000 6,549E-03 0,03305705 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 7,042E-03 0,03546975 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 7,042E-03 0,03539676 ! regulation of viral reproduction GO:0050792 41 24 1,000 7,042E-03 0,03532408 ! oogenesis GO:0048477 44 24 1,000 7,042E-03 0,03525169 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 7,042E-03 0,0351796 ! regulation of caspase activity GO:0043281 136 74 2,000 7,064E-03 0,03522008 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 7,064E-03 0,03514835 ! respiratory system development GO:0060541 175 74 2,000 7,064E-03 0,03507691 ! regulation of transcription factor activity GO:0051090 137 75 2,000 7,33E-03 0,03632522 GO:0090046|regulation of transcription regulator activity, ! cell-matrix adhesion GO:0007160 181 76 2,000 7,603E-03 0,03759754 ! lymphocyte differentiation GO:0030098 193 76 2,000 7,603E-03 0,03752159 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 7,628E-03 0,03756943 ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 7,628E-03 0,03749383 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 7,628E-03 0,03741854 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 7,628E-03 0,03734356 ! interaction with host GO:0051701 66 25 1,000 7,628E-03 0,03726887 ! lymphocyte proliferation GO:0046651 55 25 1,000 7,628E-03 0,03719448 ! regulation of biomineral formation GO:0070167 56 25 1,000 7,628E-03 0,03712039 ! leukocyte homeostasis GO:0001776 50 25 1,000 7,628E-03 0,03704659 ! liver development GO:0001889 55 25 1,000 7,628E-03 0,03697309 ! protein tetramerization GO:0051262 57 25 1,000 7,628E-03 0,03689987 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 7,881E-03 0,03804835 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 8,165E-03 0,03934169 ! multicellular organismal response to stress GO:0033555 61 26 1,000 8,235E-03 0,03960222 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 8,235E-03 0,03952441 ! coenzyme catabolic process GO:0009109 42 26 1,000 8,235E-03 0,03944692 ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 8,235E-03 0,03936972 ! positive regulation of nuclear division GO:0051785 41 26 1,000 8,235E-03 0,03929283 GO:0045840|positive regulation of mitosis, ! response to steroid hormone stimulus GO:0048545 147 79 2,000 8,455E-03 0,04026233 ! protein oligomerization GO:0051259 149 79 2,000 8,455E-03 0,04018399 ! activation of protein kinase activity GO:0032147 170 80 2,000 8,751E-03 0,04150978 ! development of primary sexual characteristics GO:0045137 143 80 2,000 8,751E-03 0,04142934 ! acetyl-CoA metabolic process GO:0006084 41 27 1,000 8,863E-03 0,04188147 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 8,863E-03 0,04180062 ! mitochondrial membrane organization GO:0007006 60 27 1,000 8,863E-03 0,04172008 ! response to toxin GO:0009636 49 27 1,000 8,863E-03 0,04163985 ! cellular response to oxidative stress GO:0034599 43 27 1,000 8,863E-03 0,04155993 ! leukocyte proliferation GO:0070661 59 27 1,000 8,863E-03 0,04148031 GO:0032943|mononuclear cell proliferation, ! meiosis GO:0007126 143 81 2,000 9,052E-03 0,04228526 GO:0051327|M phase of meiotic cell cycle, ! regulation of peptidase activity GO:0052547 150 82 2,000 9,36E-03 0,04364045 ! meiotic cell cycle GO:0051321 144 82 2,000 9,36E-03 0,04355733 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 9,512E-03 0,04417917 ! protein amino acid acylation GO:0043543 59 28 1,000 9,512E-03 0,04409534 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 9,512E-03 0,04401183 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 9,512E-03 0,04392863 ! response to metal ion GO:0010038 158 84 2,000 9,995E-03 0,0460696 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01018171 0,04684356 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 1,000 0,01018171 0,0467555 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 1,000 0,01018171 0,04666778 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01018171 0,04658039 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01018171 0,04649332 ! somitogenesis GO:0001756 52 29 1,000 0,01018171 0,04640658 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01018171 0,04632016 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01018171 0,04623407 ! negative regulation of transport GO:0051051 164 85 2,000 0,01032087 0,04677901 ! cholesterol metabolic process GO:0008203 148 85 2,000 0,01032087 0,04669238 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,01032087 0,04660607 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,01065323 0,04801817 GO:0002696|positive regulation of leukocyte activation, ! phenol metabolic process GO:0018958 56 30 1,000 0,01087155 0,04891198 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 0,01087155 0,04882206 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01087155 0,04873248 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,01087155 0,04864323 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 0,01087155 0,0485543 GO:0048871|multicellular organismal homeostasis, ! ovulation cycle process GO:0022602 55 31 1,000 0,01158146 0,05163049 ! peptide transport GO:0015833 60 31 1,000 0,01158146 0,05153645 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01158146 0,05144274 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01158146 0,05134938 ! cofactor catabolic process GO:0051187 54 31 1,000 0,01158146 0,05125636 ! response to heat GO:0009408 54 31 1,000 0,01158146 0,05116367 ! regulation of DNA binding GO:0051101 167 89 2,000 0,01168729 0,05153799 ! response to inorganic substance GO:0010035 173 90 2,000 0,01204436 0,05301687 ! positive regulation of protein modification process GO:0031401 156 90 2,000 0,01204436 0,05292151 ! ovulation cycle GO:0042698 57 32 1,000 0,01231121 0,05399693 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01231121 0,05390016 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,01231121 0,05380374 ! myeloid leukocyte activation GO:0002274 53 32 1,000 0,01231121 0,05370766 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01231121 0,05361192 ! ossification GO:0001503 205 91 2,000 0,01240764 0,05393571 ! bone development GO:0060348 206 92 2,000 0,01277717 0,05544337 ! cholesterol homeostasis GO:0042632 60 33 1,000 0,01306058 0,05657268 GO:0055092|sterol homeostasis, ! positive regulation of neurogenesis GO:0050769 72 33 1,000 0,01306058 0,05647255 ! response to ionizing radiation GO:0010212 74 33 1,000 0,01306058 0,05637278 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 2,000 0,01315294 0,05667131 GO:0010498|proteasomal protein catabolic process, ! sterol metabolic process GO:0016125 166 94 2,000 0,01353498 0,05821471 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01382934 0,05937622 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01382934 0,05927205 ! positive regulation of endocytosis GO:0045807 56 35 1,000 0,01461726 0,06253936 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01461726 0,06243003 ! biogenic amine biosynthetic process GO:0042401 65 35 1,000 0,01461726 0,06232108 ! placenta development GO:0001890 53 35 1,000 0,01461726 0,0622125 ! transcription initiation GO:0006352 171 97 2,000 0,01471882 0,06253581 ! regulation of protein localization GO:0032880 188 97 2,000 0,01471882 0,06242724 ! regulation of muscle development GO:0048634 82 36 1,000 0,01542414 0,06530533 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 0,01542414 0,06519234 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,01542414 0,06507975 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01542414 0,06496754 ! aerobic respiration GO:0009060 56 36 1,000 0,01542414 0,06485572 ! cytokine production GO:0001816 68 36 1,000 0,01542414 0,06474429 ! embryonic organ development GO:0048568 67 36 1,000 0,01542414 0,06463323 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,01624975 0,06797625 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01624975 0,06786005 ! odontogenesis GO:0042476 74 37 1,000 0,01624975 0,06774425 ! female gonad development GO:0008585 71 37 1,000 0,01624975 0,06762884 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 0,01624975 0,06751383 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,01624975 0,0673992 ! meiosis I GO:0007127 74 38 1,000 0,01709386 0,07078019 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,01709386 0,07066042 ! spermatid development GO:0007286 69 38 1,000 0,01709386 0,07054106 ! glycogen metabolic process GO:0005977 63 38 1,000 0,01709386 0,07042211 ! pigment metabolic process GO:0042440 87 38 1,000 0,01709386 0,07030355 ! negative regulation of binding GO:0051100 71 39 1,000 0,01795628 0,07372637 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,01795628 0,07360267 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,01795628 0,07347938 ! glucan metabolic process GO:0044042 64 39 1,000 0,01795628 0,07335651 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 93 40 1,000 0,01883678 0,07682512 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,01883678 0,07669708 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 1,000 0,01883678 0,07656946 ! gliogenesis GO:0042063 91 41 1,000 0,01973515 0,08008798 ! spermatid differentiation GO:0048515 73 41 1,000 0,01973515 0,07995517 ! ear morphogenesis GO:0042471 64 42 1,000 0,02065118 0,08352786 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,02065118 0,0833898 ! cytokinesis GO:0000910 84 42 1,000 0,02065118 0,08325219 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02158466 0,08687204 GO:0090047|positive regulation of transcription regulator activity, ! regulation of tube size GO:0035150 76 43 1,000 0,02158466 0,08672915 GO:0050880|regulation of blood vessel size, ! glucose transport GO:0015758 66 43 1,000 0,02158466 0,08658674 ! hormone-mediated signaling GO:0009755 84 43 1,000 0,02158466 0,0864448 ! segmentation GO:0035282 78 43 1,000 0,02158466 0,08630332 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,02253539 0,08995744 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,02253539 0,08981069 ! hexose transport GO:0008645 68 44 1,000 0,02253539 0,08966442 GO:0015749|monosaccharide transport, ! biopolymer methylation GO:0043414 91 45 1,000 0,02350316 0,09336295 ! B cell differentiation GO:0030183 124 45 1,000 0,02350316 0,09321139 ! female gamete generation GO:0007292 71 45 1,000 0,02350316 0,09306032 ! developmental growth GO:0048589 88 45 1,000 0,02350316 0,09290973 ! activation of adenylate cyclase activity GO:0007190 94 46 1,000 0,02448776 0,09664557 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,02448776 0,09648969 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,02448776 0,09633431 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02603154 0,10224283 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02603154 0,10207872 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02603154 0,10191513 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02603154 0,10175207 ! neuron fate determination GO:0048664 7 5 0,000 0,02603154 0,10158952 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02603154 0,1014275 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02603154 0,10126599 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02603154 0,101105 ! polyol transport GO:0015791 12 5 0,000 0,02603154 0,10094451 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02603154 0,10078454 ! response to superoxide GO:0000303 10 5 0,000 0,02603154 0,10062507 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02603154 0,1004661 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02603154 0,10030764 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02603154 0,10014967 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02603154 0,0999922 ! female meiosis GO:0007143 10 5 0,000 0,02603154 0,09983523 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02603154 0,09967875 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02603154 0,09952276 ! hypothalamus development GO:0021854 9 5 0,000 0,02603154 0,09936725 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02603154 0,09921223 ! cobalt ion transport GO:0006824 11 5 0,000 0,02603154 0,0990577 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02603154 0,09890364 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02603154 0,09875007 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02603154 0,09859696 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02603154 0,09844434 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02603154 0,09829218 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02603154 0,0981405 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02603154 0,09798928 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02603154 0,09783853 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02603154 0,09768824 ! transposition GO:0032196 9 5 0,000 0,02603154 0,09753841 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02603154 0,09738904 ! negative chemotaxis GO:0050919 16 5 0,000 0,02603154 0,09724013 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02603154 0,09709167 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02603154 0,09694366 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02603154 0,09679611 ! behavioral response to pain GO:0048266 10 5 0,000 0,02603154 0,096649 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02603154 0,09650234 ! Notch receptor processing GO:0007220 11 5 0,000 0,02603154 0,09635612 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02603154 0,09621035 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! micturition GO:0060073 9 5 0,000 0,02603154 0,09606502 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02603154 0,09592012 ! copulation GO:0007620 9 5 0,000 0,02603154 0,09577567 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02603154 0,09563164 ! bioluminescence GO:0008218 9 5 0,000 0,02603154 0,09548805 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02603154 0,09534489 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02603154 0,09520216 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02603154 0,09505985 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02603154 0,09491797 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02603154 0,09477652 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02603154 0,09463548 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02603154 0,09449486 ! grooming behavior GO:0007625 6 5 0,000 0,02603154 0,09435466 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02603154 0,09421488 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02603154 0,09407551 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02603154 0,09393655 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02603154 0,093798 ! response to protozoan GO:0001562 13 5 0,000 0,02603154 0,09365986 ! lymph vessel development GO:0001945 10 5 0,000 0,02603154 0,09352212 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02603154 0,09338479 ! endochondral ossification GO:0001958 17 5 0,000 0,02603154 0,09324786 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02603154 0,09311134 ! single strand break repair GO:0000012 8 5 0,000 0,02603154 0,09297521 ! parathyroid gland development GO:0060017 14 5 0,000 0,02603154 0,09283948 ! anagen GO:0042640 7 5 0,000 0,02603154 0,09270414 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02603154 0,0925692 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02603154 0,09243465 ! cytokine secretion GO:0050663 15 5 0,000 0,02603154 0,0923005 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02603154 0,09216673 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02603154 0,09203335 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02603154 0,09190035 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02603154 0,09176774 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02603154 0,09163551 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02603154 0,09150366 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02603154 0,09137219 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02603154 0,09124109 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02603154 0,09111038 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02603154 0,09098003 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02603154 0,09085006 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02603154 0,09072046 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02603154 0,09059123 ! valine metabolic process GO:0006573 12 5 0,000 0,02603154 0,09046236 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02603154 0,09033387 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02603154 0,09020573 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02603154 0,09007796 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02603154 0,08995055 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02603154 0,08982351 ! polyol catabolic process GO:0046174 9 5 0,000 0,02603154 0,08969682 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02603154 0,08957048 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02603154 0,0894445 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02603154 0,08931888 ! muscle cell migration GO:0014812 8 5 0,000 0,02603154 0,08919361 ! mitochondrial fission GO:0000266 8 5 0,000 0,02603154 0,08906869 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02603154 0,08894411 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02603154 0,08881989 ! mRNA transcription GO:0009299 10 5 0,000 0,02603154 0,08869601 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02603154 0,08857248 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02603154 0,08844929 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02603154 0,08832645 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02603154 0,08820394 ! monocyte activation GO:0042117 10 5 0,000 0,02603154 0,08808178 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02603154 0,08795995 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02603154 0,08783846 ! response to food GO:0032094 6 5 0,000 0,02603154 0,0877173 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02603154 0,08759648 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02603154 0,08747599 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02603154 0,08735583 GO:0032881|regulation of polysaccharide metabolic process, ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02603154 0,087236 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02603154 0,0871165 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02603154 0,08699732 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02603154 0,08687847 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02603154 0,08675995 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02603154 0,08664175 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02603154 0,08652387 ! lipid glycosylation GO:0030259 7 5 0,000 0,02603154 0,08640631 ! nucleobase transport GO:0015851 6 5 0,000 0,02603154 0,08628907 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02603154 0,08617214 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02603154 0,08605554 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02603154 0,08593925 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02603154 0,08582327 ! basic amino acid transport GO:0015802 12 5 0,000 0,02603154 0,0857076 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02603154 0,08559225 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02603154 0,08547721 ! actin nucleation GO:0045010 11 5 0,000 0,02603154 0,08536247 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02603154 0,08524805 ! depurination GO:0045007 5 5 0,000 0,02603154 0,08513393 ! depyrimidination GO:0045008 10 5 0,000 0,02603154 0,08502011 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02603154 0,0849066 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02603154 0,08479339 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02603154 0,08468048 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02603154 0,08456788 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02603154 0,08445557 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02603154 0,08434356 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02603154 0,08423184 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02603154 0,08412043 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02603154 0,0840093 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02603154 0,08389847 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02603154 0,08378793 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02603154 0,08367769 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02603154 0,08356773 ! response to arsenic GO:0046685 11 5 0,000 0,02603154 0,08345806 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02603154 0,08334868 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02603154 0,08323958 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02603154 0,08313077 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02603154 0,08302225 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02603154 0,08291401 ! response to mercury ion GO:0046689 8 5 0,000 0,02603154 0,08280604 ! response to cadmium ion GO:0046686 7 5 0,000 0,02603154 0,08269836 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02603154 0,08259096 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02603154 0,08248384 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02603154 0,082377 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02603154 0,08227043 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02603154 0,08216414 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02603154 0,08205812 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02603154 0,08195237 ! decidualization GO:0046697 11 5 0,000 0,02603154 0,0818469 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02603154 0,0817417 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02603154 0,08163677 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02603154 0,08153211 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02603154 0,08142771 ! embryonic cleavage GO:0040016 6 5 0,000 0,02603154 0,08132358 ! peroxisome fission GO:0016559 5 5 0,000 0,02603154 0,08121972 ! histone demethylation GO:0016577 13 5 0,000 0,02603154 0,08111613 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02603154 0,08101279 ! mitotic recombination GO:0006312 9 5 0,000 0,02603154 0,08090972 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02603154 0,08080692 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02603154 0,08070437 ! metaphase plate congression GO:0051310 7 5 0,000 0,02603154 0,08060208 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02603154 0,08050005 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02603154 0,08039828 ! enteric nervous system development GO:0048484 8 5 0,000 0,02603154 0,08029677 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02603154 0,08019551 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02603154 0,08009451 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02603154 0,07999376 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02603154 0,07989327 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02603154 0,07979303 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02603154 0,07969304 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02603154 0,07959329 ! metaphase GO:0051323 11 5 0,000 0,02603154 0,0794938 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02603154 0,07939456 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02603154 0,07929556 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02603154 0,07919681 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02603154 0,07909831 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02603154 0,07900005 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02603154 0,07890204 ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02603154 0,07880427 ! response to redox state GO:0051775 6 5 0,000 0,02603154 0,07870674 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02603154 0,07860945 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02603154 0,0785124 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02603154 0,07841559 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02603154 0,07831902 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02603154 0,07822268 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02603154 0,07812659 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02603154 0,07803073 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02603154 0,0779351 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02603154 0,07783971 ! striatum development GO:0021756 14 5 0,000 0,02603154 0,07774455 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02603154 0,07764962 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02603154 0,07755493 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02603154 0,07746047 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02603154 0,07736623 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02603154 0,07727223 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02603154 0,07717845 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02603154 0,0770849 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02603154 0,07699158 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02603154 0,07689848 ! neuroprotection GO:0043526 8 5 0,000 0,02603154 0,07680561 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02603154 0,07671296 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02603154 0,07662053 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02603154 0,07652833 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02603154 0,07643635 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02603154 0,07634459 GO:0051497|negative regulation of stress fiber formation, ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02603154 0,07625305 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02603154 0,07616173 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02603154 0,07607062 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02603154 0,07597974 ! spindle assembly GO:0051225 6 5 0,000 0,02603154 0,07588907 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02603154 0,07579862 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02603154 0,07570838 ! protein palmitoylation GO:0018345 12 5 0,000 0,02603154 0,07561836 ! drug metabolic process GO:0017144 7 5 0,000 0,02603154 0,07552855 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02603154 0,07543896 ! organ regeneration GO:0031100 7 5 0,000 0,02603154 0,07534958 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02603154 0,0752604 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02603154 0,07517144 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 1,000 0,02650668 0,07645314 ! mitochondrial transport GO:0006839 94 48 1,000 0,02650668 0,07636299 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,02650668 0,07627304 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,02650668 0,07618331 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,02650668 0,07609379 ! methylation GO:0032259 97 48 1,000 0,02650668 0,07600448 ! response to calcium ion GO:0051592 94 49 1,000 0,02754059 0,0788765 ! positive regulation of cyclase activity GO:0031281 106 49 1,000 0,02754059 0,07878414 ! JNK cascade GO:0007254 106 49 1,000 0,02754059 0,078692 ! protein homooligomerization GO:0051260 84 49 1,000 0,02754059 0,07860007 ! endocrine system development GO:0035270 109 50 1,000 0,02859054 0,08150138 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,02859054 0,08140639 ! positive regulation of lyase activity GO:0051349 107 50 1,000 0,02859054 0,08131162 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,02965633 0,08424467 ! response to temperature stimulus GO:0009266 84 51 1,000 0,02965633 0,08414682 ! positive regulation of binding GO:0051099 88 52 1,000 0,03073777 0,08711413 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,03073777 0,08701318 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,03073777 0,08691247 ! histone modification GO:0016570 104 52 1,000 0,03073777 0,086812 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,03073777 0,08671175 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03115639 0,0877913 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03115639 0,08769016 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03115639 0,08758925 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03115639 0,08748857 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03115639 0,08738812 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03115639 0,08728791 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03115639 0,08718792 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03115639 0,08708816 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03115639 0,08698863 ! response to oxygen radical GO:0000305 11 6 0,000 0,03115639 0,08688933 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03115639 0,08679026 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03115639 0,08669141 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03115639 0,08659278 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03115639 0,08649438 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03115639 0,0863962 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03115639 0,08629825 ! forebrain regionalization GO:0021871 9 6 0,000 0,03115639 0,08620052 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03115639 0,086103 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03115639 0,08600571 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03115639 0,08590864 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03115639 0,08581179 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03115639 0,08571515 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03115639 0,08561873 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03115639 0,08552253 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03115639 0,08542655 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03115639 0,08533078 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03115639 0,08523522 ! malate metabolic process GO:0006108 13 6 0,000 0,03115639 0,08513988 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03115639 0,08504475 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03115639 0,08494984 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03115639 0,08485513 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03115639 0,08476064 ! protein refolding GO:0042026 15 6 0,000 0,03115639 0,08466636 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03115639 0,08457228 ! opsonization GO:0008228 8 6 0,000 0,03115639 0,08447842 ! mating behavior GO:0007617 7 6 0,000 0,03115639 0,08438476 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03115639 0,08429131 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03115639 0,08419807 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03115639 0,08410503 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03115639 0,0840122 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03115639 0,08391958 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03115639 0,08382715 ! toxin metabolic process GO:0009404 11 6 0,000 0,03115639 0,08373493 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03115639 0,08364292 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03115639 0,0835511 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03115639 0,08345949 ! nuclear migration GO:0007097 13 6 0,000 0,03115639 0,08336808 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03115639 0,08327687 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03115639 0,08318585 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03115639 0,08309504 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03115639 0,08300442 ! thymic T cell selection GO:0045061 16 6 0,000 0,03115639 0,082914 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03115639 0,08282378 ! protein lipoylation GO:0009249 10 6 0,000 0,03115639 0,08273376 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03115639 0,08264392 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03115639 0,08255429 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03115639 0,08246485 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03115639 0,0823756 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03115639 0,08228655 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03115639 0,08219768 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03115639 0,08210901 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03115639 0,08202053 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03115639 0,08193224 ! hyperosmotic response GO:0006972 10 6 0,000 0,03115639 0,08184414 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03115639 0,08175623 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03115639 0,08166851 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03115639 0,08158098 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03115639 0,08149363 ! urea metabolic process GO:0019627 7 6 0,000 0,03115639 0,08140648 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03115639 0,0813195 ! neutrophil activation GO:0042119 7 6 0,000 0,03115639 0,08123272 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03115639 0,08114611 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03115639 0,0810597 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03115639 0,08097346 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03115639 0,08088741 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03115639 0,08080154 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03115639 0,08071586 ! neuron apoptosis GO:0051402 15 6 0,000 0,03115639 0,08063035 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03115639 0,08054503 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03115639 0,08045989 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03115639 0,08037493 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03115639 0,08029014 ! carnitine transport GO:0015879 10 6 0,000 0,03115639 0,08020554 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03115639 0,08012111 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03115639 0,08003686 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03115639 0,07995279 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,03115639 0,07986889 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03115639 0,07978517 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03115639 0,07970163 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03115639 0,07961826 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03115639 0,07953506 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03115639 0,07945204 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03115639 0,07936919 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03115639 0,07928652 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,03115639 0,07920401 ! astrocyte development GO:0014002 16 6 0,000 0,03115639 0,07912168 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03115639 0,07903952 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03115639 0,07895753 ! interaction with symbiont GO:0051702 14 6 0,000 0,03115639 0,0788757 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03115639 0,07879405 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03115639 0,07871257 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03115639 0,07863125 ! response to copper ion GO:0046688 10 6 0,000 0,03115639 0,07855011 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03115639 0,07846913 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03115639 0,07838832 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03115639 0,07830767 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03115639 0,07822719 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03115639 0,07814687 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03115639 0,07806672 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03115639 0,07798674 ! hair follicle maturation GO:0048820 8 6 0,000 0,03115639 0,07790691 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03115639 0,07782725 ! Schwann cell development GO:0014044 15 6 0,000 0,03115639 0,07774776 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03115639 0,07766842 ! response to pheromone GO:0019236 6 6 0,000 0,03115639 0,07758925 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03115639 0,07751024 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03115639 0,07743139 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03115639 0,0773527 ! subpallium development GO:0021544 15 6 0,000 0,03115639 0,07727417 ! neural tube patterning GO:0021532 8 6 0,000 0,03115639 0,0771958 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03115639 0,07711758 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03115639 0,07703953 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03115639 0,07696163 ! G2 phase GO:0051319 16 6 0,000 0,03115639 0,07688389 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03115639 0,07680631 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03115639 0,07672889 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03115639 0,07665162 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03115639 0,0765745 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03115639 0,07649754 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03115639 0,07642074 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03115639 0,07634409 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03115639 0,07626759 ! receptor internalization GO:0031623 11 6 0,000 0,03115639 0,07619125 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03115639 0,07611505 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03115639 0,07603902 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03115639 0,07596313 ! protein deubiquitination GO:0016579 16 6 0,000 0,03115639 0,07588739 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03115639 0,07581181 ! protein destabilization GO:0031648 9 6 0,000 0,03115639 0,07573637 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03115639 0,07566109 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03115639 0,07558595 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03115639 0,07551097 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03115639 0,07543613 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03115639 0,07536144 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03115639 0,0752869 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03115639 0,0752125 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03115639 0,07513826 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03115639 0,07506416 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03115639 0,0749902 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03115639 0,07491639 ! neural plate development GO:0001840 9 6 0,000 0,03115639 0,07484273 ! catecholamine transport GO:0051937 9 6 0,000 0,03115639 0,07476921 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03115639 0,07469583 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03115639 0,0746226 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03115639 0,07454951 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03115639 0,07447657 ! maternal placenta development GO:0001893 12 6 0,000 0,03115639 0,07440377 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03115639 0,07433111 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03115639 0,07425859 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03115639 0,07418621 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03115639 0,07411398 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03115639 0,07404188 GO:0055081|anion homeostasis, ! vesicle organization GO:0016050 127 53 1,000 0,03183467 0,07558027 ! synapse organization GO:0050808 102 53 1,000 0,03183467 0,07550689 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,03294684 0,07806898 ! membrane fusion GO:0006944 122 54 1,000 0,03294684 0,07799334 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,03294684 0,07791783 ! covalent chromatin modification GO:0016569 115 54 1,000 0,03294684 0,07784248 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,03407408 0,080428 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,03521621 0,08304364 ! RNA elongation GO:0006354 90 56 1,000 0,03521621 0,08296356 ! tRNA transcription GO:0009304 17 7 0,000 0,03625442 0,08532711 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03625442 0,08524499 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03625442 0,08516302 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03625442 0,08508121 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03625442 0,08499956 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03625442 0,08491806 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03625442 0,08483672 ! sleep GO:0030431 16 7 0,000 0,03625442 0,08475554 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03625442 0,08467451 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03625442 0,08459364 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03625442 0,08451292 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03625442 0,08443235 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03625442 0,08435194 GO:0070193|synaptonemal complex organization, ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03625442 0,08427168 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03625442 0,08419158 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03625442 0,08411162 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03625442 0,08403182 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03625442 0,08395217 ! glycolipid transport GO:0046836 11 7 0,000 0,03625442 0,08387267 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03625442 0,08379332 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,03625442 0,08371412 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03625442 0,08363507 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03625442 0,08355617 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03625442 0,08347742 ! mRNA stabilization GO:0048255 18 7 0,000 0,03625442 0,08339881 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,03625442 0,08332036 ! fibril organization GO:0043206 17 7 0,000 0,03625442 0,08324205 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,03625442 0,08316389 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03625442 0,08308587 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03625442 0,083008 ! lipoprotein transport GO:0042953 14 7 0,000 0,03625442 0,08293028 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03625442 0,0828527 ! rhythmic behavior GO:0007622 17 7 0,000 0,03625442 0,08277527 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03625442 0,08269798 GO:0042069|regulation of catecholamine metabolic process, ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03625442 0,08262084 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03625442 0,08254384 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03625442 0,08246698 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03625442 0,08239027 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03625442 0,0823137 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03625442 0,08223727 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03625442 0,08216098 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03625442 0,08208484 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03625442 0,08200883 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03625442 0,08193297 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03625442 0,08185725 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03625442 0,08178166 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03625442 0,08170622 ! spinal cord patterning GO:0021511 14 7 0,000 0,03625442 0,08163091 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03625442 0,08155575 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03625442 0,08148072 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03625442 0,08140583 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03625442 0,08133107 ! adrenal gland development GO:0030325 17 7 0,000 0,03625442 0,08125646 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03625442 0,08118198 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03625442 0,08110764 ! ovulation GO:0030728 10 7 0,000 0,03625442 0,08103343 ! adenohypophysis development GO:0021984 11 7 0,000 0,03625442 0,08095936 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03625442 0,08088542 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03625442 0,08081162 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03625442 0,08073796 ! microtubule nucleation GO:0007020 21 7 0,000 0,03625442 0,08066443 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03625442 0,08059103 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03625442 0,08051776 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03625442 0,08044463 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03625442 0,08037163 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03625442 0,08029877 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03625442 0,08022603 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03625442 0,08015343 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03625442 0,08008096 ! galactose metabolic process GO:0006012 13 7 0,000 0,03625442 0,08000862 ! vesicle fusion GO:0006906 20 7 0,000 0,03625442 0,07993641 ! response to dietary excess GO:0002021 8 7 0,000 0,03625442 0,07986433 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03625442 0,07979238 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03625442 0,07972056 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03625442 0,07964887 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,03625442 0,0795773 ! nucleoside transport GO:0015858 11 7 0,000 0,03625442 0,07950587 ! nucleoside salvage GO:0043174 11 7 0,000 0,03625442 0,07943456 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03625442 0,07936339 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03625442 0,07929234 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03625442 0,07922141 ! parturition GO:0007567 16 7 0,000 0,03625442 0,07915062 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03625442 0,07907995 ! rRNA modification GO:0000154 14 7 0,000 0,03625442 0,0790094 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03625442 0,07893898 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03625442 0,07886869 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03625442 0,07879852 ! monocyte differentiation GO:0030224 16 7 0,000 0,03625442 0,07872848 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03625442 0,07865856 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03625442 0,07858877 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03625442 0,0785191 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03625442 0,07844955 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03625442 0,07838012 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03625442 0,07831082 ! fibrinolysis GO:0042730 11 7 0,000 0,03625442 0,07824164 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03625442 0,07817259 ! eating behavior GO:0042755 8 7 0,000 0,03625442 0,07810365 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03625442 0,07803484 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03625442 0,07796614 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03625442 0,07789757 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03625442 0,07782912 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03625442 0,07776079 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03625442 0,07769258 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03625442 0,07762449 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03625442 0,07755651 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03625442 0,07748866 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03625442 0,07742093 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03625442 0,07735331 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03625442 0,07728581 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03625442 0,07721843 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03625442 0,07715117 ! histone ubiquitination GO:0016574 9 7 0,000 0,03625442 0,07708402 ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03625442 0,07701699 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03625442 0,07695008 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03625442 0,07688328 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03625442 0,0768166 ! transcription termination GO:0006353 14 7 0,000 0,03625442 0,07675003 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03625442 0,07668358 ! anaphase GO:0051322 18 7 0,000 0,03625442 0,07661725 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03625442 0,07655103 ! axonal fasciculation GO:0007413 19 7 0,000 0,03625442 0,07648492 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03625442 0,07641893 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03625442 0,07635305 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,03625442 0,07628729 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03625442 0,07622163 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03625442 0,0761561 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03625442 0,07609067 ! antibiotic transport GO:0042891 9 7 0,000 0,03625442 0,07602536 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03625442 0,07596015 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03625442 0,07589506 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03625442 0,07583009 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03625442 0,07576522 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03625442 0,07570046 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03625442 0,07563582 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03625442 0,07557128 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03625442 0,07550685 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03625442 0,07544254 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03625442 0,07537833 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03625442 0,07531423 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03625442 0,07525025 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03625442 0,07518637 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03625442 0,0751226 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03625442 0,07505893 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03625442 0,07499538 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03625442 0,07493193 ! muscle adaptation GO:0043500 13 7 0,000 0,03625442 0,07486859 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03625442 0,07480535 ! retina homeostasis GO:0001895 12 7 0,000 0,03625442 0,07474223 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03625442 0,07467921 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03625442 0,07461629 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03625442 0,07455348 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03625442 0,07449078 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,03637305 0,07467173 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,03637305 0,07460904 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,03754441 0,07694714 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,03754441 0,07688264 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 1,000 0,03754441 0,07681825 ! maintenance of location GO:0051235 124 58 1,000 0,03754441 0,07675396 ! nuclear export GO:0051168 110 59 1,000 0,0387301 0,07911173 ! establishment of organelle localization GO:0051656 122 59 1,000 0,0387301 0,07904564 ! lipid modification GO:0030258 112 60 1,000 0,03992995 0,08142643 ! regulation of endocytosis GO:0030100 104 60 1,000 0,03992995 0,08135852 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,04114377 0,08376186 ! camera-type eye development GO:0043010 126 61 1,000 0,04114377 0,08369211 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04132576 0,08399238 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04132576 0,08392256 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04132576 0,08385286 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04132576 0,08378327 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04132576 0,0837138 ! male meiosis GO:0007140 9 8 0,000 0,04132576 0,08364444 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04132576 0,0835752 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04132576 0,08350607 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04132576 0,08343706 ! meiotic prophase I GO:0007128 14 8 0,000 0,04132576 0,08336816 ! response to zinc ion GO:0010043 12 8 0,000 0,04132576 0,08329937 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,04132576 0,0832307 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04132576 0,08316214 ! oligopeptide transport GO:0006857 16 8 0,000 0,04132576 0,08309369 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04132576 0,08302536 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04132576 0,08295714 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04132576 0,08288903 ! signal peptide processing GO:0006465 12 8 0,000 0,04132576 0,08282103 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04132576 0,08275315 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04132576 0,08268537 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04132576 0,08261771 ! succinate metabolic process GO:0006105 17 8 0,000 0,04132576 0,08255015 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04132576 0,08248271 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04132576 0,08241538 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04132576 0,08234816 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04132576 0,08228104 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04132576 0,08221404 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04132576 0,08214714 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04132576 0,08208036 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04132576 0,08201368 ! reflex GO:0060004 17 8 0,000 0,04132576 0,08194711 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04132576 0,08188065 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04132576 0,08181429 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04132576 0,08174805 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04132576 0,08168191 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04132576 0,08161588 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04132576 0,08154995 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04132576 0,08148413 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04132576 0,08141842 ! histidine catabolic process GO:0006548 10 8 0,000 0,04132576 0,08135281 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04132576 0,08128731 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04132576 0,08122191 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04132576 0,08115662 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04132576 0,08109144 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04132576 0,08102635 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04132576 0,08096138 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04132576 0,0808965 ! macrophage activation GO:0042116 13 8 0,000 0,04132576 0,08083174 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04132576 0,08076707 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04132576 0,08070251 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04132576 0,08063805 ! purine salvage GO:0043101 12 8 0,000 0,04132576 0,08057369 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04132576 0,08050944 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04132576 0,08044529 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04132576 0,08038124 ! osteoblast development GO:0002076 17 8 0,000 0,04132576 0,08031729 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04132576 0,08025345 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04132576 0,0801897 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04132576 0,08012606 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04132576 0,08006252 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04132576 0,07999908 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04132576 0,07993574 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04132576 0,0798725 ! intermediate filament organization GO:0045109 12 8 0,000 0,04132576 0,07980936 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04132576 0,07974632 ! cellular extravasation GO:0045123 13 8 0,000 0,04132576 0,07968338 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04132576 0,07962053 ! response to antibiotic GO:0046677 11 8 0,000 0,04132576 0,07955779 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04132576 0,07949515 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04132576 0,0794326 ! DNA topological change GO:0006265 12 8 0,000 0,04132576 0,07937016 ! response to tropane GO:0014073 15 8 0,000 0,04132576 0,07930781 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04132576 0,07924556 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04132576 0,0791834 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04132576 0,07912135 ! mast cell activation GO:0045576 14 8 0,000 0,04132576 0,07905939 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04132576 0,07899753 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04132576 0,07893576 ! gas homeostasis GO:0033483 14 8 0,000 0,04132576 0,07887409 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04132576 0,07881252 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04132576 0,07875104 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04132576 0,07868966 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04132576 0,07862838 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04132576 0,07856719 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04132576 0,07850609 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04132576 0,0784451 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04132576 0,07838419 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04132576 0,07832338 ! response to tumor cell GO:0002347 16 8 0,000 0,04132576 0,07826267 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04132576 0,07820204 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04132576 0,07814152 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04132576 0,07808108 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04132576 0,07802074 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04132576 0,07796049 ! hormone catabolic process GO:0042447 17 8 0,000 0,04132576 0,07790034 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04132576 0,07784028 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04132576 0,07778031 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04132576 0,07772043 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04132576 0,07766064 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04132576 0,07760095 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04132576 0,07754135 ! adult feeding behavior GO:0008343 10 8 0,000 0,04132576 0,07748184 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04132576 0,07742242 ! ATP catabolic process GO:0006200 11 8 0,000 0,04132576 0,07736309 ! blastocyst growth GO:0001832 19 8 0,000 0,04132576 0,07730386 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04132576 0,07724471 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04132576 0,07718566 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04132576 0,07712669 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04132576 0,07706782 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04132576 0,07700903 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04132576 0,07695033 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04132576 0,07689173 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04132576 0,07683321 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04132576 0,07677478 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04132576 0,07671644 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04132576 0,07665819 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04132576 0,07660003 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04132576 0,07654195 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04132576 0,07648397 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04132576 0,07642607 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04132576 0,07636826 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04132576 0,07631054 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04132576 0,0762529 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04132576 0,07619535 ! viral reproductive process GO:0022415 132 62 1,000 0,04237139 0,07806433 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,04613526 0,08493477 GO:0048609|reproductive process in a multicellular organism, ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04637056 0,08530368 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04637056 0,0852395 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04637056 0,08517541 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,04637056 0,08511141 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,04637056 0,08504751 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,04637056 0,08498371 ! reproductive behavior GO:0019098 22 9 0,000 0,04637056 0,08492001 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04637056 0,0848564 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,04637056 0,08479288 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04637056 0,08472946 ! UTP metabolic process GO:0046051 10 9 0,000 0,04637056 0,08466614 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,04637056 0,0846029 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04637056 0,08453977 ! artery development GO:0060840 25 9 0,000 0,04637056 0,08447673 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,04637056 0,08441378 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,04637056 0,08435092 ! equilibrioception GO:0050957 20 9 0,000 0,04637056 0,08428816 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,04637056 0,08422549 ! chemosensory behavior GO:0007635 21 9 0,000 0,04637056 0,08416292 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,04637056 0,08410044 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04637056 0,08403805 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,04637056 0,08397575 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04637056 0,08391355 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04637056 0,08385144 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,04637056 0,08378942 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04637056 0,08372749 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04637056 0,08366565 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04637056 0,0836039 ! protein targeting to ER GO:0045047 25 9 0,000 0,04637056 0,08354225 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04637056 0,08348068 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,04637056 0,08341921 ! glycine catabolic process GO:0006546 15 9 0,000 0,04637056 0,08335783 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04637056 0,08329654 ! endosome organization GO:0007032 20 9 0,000 0,04637056 0,08323533 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04637056 0,08317422 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04637056 0,0831132 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04637056 0,08305226 ! mannose metabolic process GO:0006013 13 9 0,000 0,04637056 0,08299142 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04637056 0,08293067 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04637056 0,08287 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04637056 0,08280942 ! receptor clustering GO:0043113 20 9 0,000 0,04637056 0,08274893 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04637056 0,08268853 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04637056 0,08262822 ! retinol metabolic process GO:0042572 20 9 0,000 0,04637056 0,082568 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04637056 0,08250786 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04637056 0,08244781 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,04637056 0,08238785 ! macrophage differentiation GO:0030225 15 9 0,000 0,04637056 0,08232797 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04637056 0,08226818 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,04637056 0,08220848 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04637056 0,08214887 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04637056 0,08208934 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04637056 0,0820299 ! response to amine stimulus GO:0014075 13 9 0,000 0,04637056 0,08197054 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04637056 0,08191127 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04637056 0,08185209 ! erythrocyte development GO:0048821 17 9 0,000 0,04637056 0,08179299 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04637056 0,08173397 ! renal water homeostasis GO:0003091 15 9 0,000 0,04637056 0,08167505 ! postreplication repair GO:0006301 25 9 0,000 0,04637056 0,0816162 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04637056 0,08155744 ! icosanoid secretion GO:0032309 15 9 0,000 0,04637056 0,08149877 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04637056 0,08144018 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,04637056 0,08138167 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04637056 0,08132325 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04637056 0,08126491 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04637056 0,08120666 ! sterol catabolic process GO:0016127 14 9 0,000 0,04637056 0,08114849 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04637056 0,0810904 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04637056 0,0810324 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,04637056 0,08097447 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,04637056 0,08091664 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,04637056 0,08085888 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,04637056 0,0808012 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,04637056 0,08074361 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,04637056 0,0806861 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04637056 0,08062868 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04637056 0,08057133 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04637056 0,08051406 ! purine base metabolic process GO:0006144 25 9 0,000 0,04637056 0,08045688 ! pigment granule transport GO:0051904 17 9 0,000 0,04637056 0,08039978 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,04637056 0,08034276 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04637056 0,08028582 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04637056 0,08022896 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04637056 0,08017218 ! mitochondrion localization GO:0051646 18 9 0,000 0,04637056 0,08011548 ! activation of MAPK activity GO:0000187 124 67 1,000 0,04871028 0,08409839 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 1,000 0,04871028 0,08403899 ! secondary metabolic process GO:0019748 125 67 1,000 0,04871028 0,08397969 ! myeloid cell differentiation GO:0030099 126 67 1,000 0,04871028 0,08392046 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,05001701 0,08611103 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,05001701 0,08605039 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,05001701 0,08598983 ! viral reproduction GO:0016032 142 68 1,000 0,05001701 0,08592936 ! cell projection assembly GO:0030031 138 68 1,000 0,05001701 0,08586898 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,05133633 0,08807208 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,05133633 0,08801028 ! single fertilization GO:0007338 83 69 1,000 0,05133633 0,08794856 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,05138896 0,08797704 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05138896 0,08791543 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05138896 0,08785391 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05138896 0,08779247 ! associative learning GO:0008306 21 10 0,000 0,05138896 0,08773112 ! phosphate transport GO:0006817 24 10 0,000 0,05138896 0,08766985 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05138896 0,08760867 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,05138896 0,08754758 ! CTP metabolic process GO:0046036 11 10 0,000 0,05138896 0,08748657 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 11 10 0,000 0,05138896 0,08742565 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05138896 0,08736481 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05138896 0,08730405 ! social behavior GO:0035176 29 10 0,000 0,05138896 0,08724338 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,05138896 0,0871828 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,05138896 0,0871223 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,05138896 0,08706188 ! androgen metabolic process GO:0008209 17 10 0,000 0,05138896 0,08700155 ! phospholipid efflux GO:0033700 19 10 0,000 0,05138896 0,0869413 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05138896 0,08688113 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05138896 0,08682104 ! lung alveolus development GO:0048286 26 10 0,000 0,05138896 0,08676104 ! pathogenesis GO:0009405 17 10 0,000 0,05138896 0,08670113 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05138896 0,08664129 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,05138896 0,08658154 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05138896 0,08652187 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,05138896 0,08646228 ! endoderm development GO:0007492 18 10 0,000 0,05138896 0,08640277 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,05138896 0,08634335 ! arginine catabolic process GO:0006527 17 10 0,000 0,05138896 0,08628401 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05138896 0,08622475 ! proline metabolic process GO:0006560 13 10 0,000 0,05138896 0,08616557 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05138896 0,08610647 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,05138896 0,08604745 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05138896 0,08598851 ! V(D)J recombination GO:0033151 34 10 0,000 0,05138896 0,08592966 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05138896 0,08587088 ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05138896 0,08581219 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,05138896 0,08575357 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05138896 0,08569504 ! multicellular organism growth GO:0035264 19 10 0,000 0,05138896 0,08563658 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05138896 0,08557821 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,05138896 0,08551991 ! ruffle organization GO:0031529 17 10 0,000 0,05138896 0,0854617 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05138896 0,08540356 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05138896 0,0853455 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05138896 0,08528752 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05138896 0,08522962 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,05138896 0,0851718 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05138896 0,08511405 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,05138896 0,08505639 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05138896 0,0849988 ! regulation of bone resorption GO:0045124 25 10 0,000 0,05138896 0,08494129 ! brain morphogenesis GO:0048854 23 10 0,000 0,05138896 0,08488386 ! segment specification GO:0007379 15 10 0,000 0,05138896 0,08482651 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05138896 0,08476923 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05138896 0,08471203 ! response to dsRNA GO:0043331 23 10 0,000 0,05138896 0,08465491 ! DNA ligation GO:0006266 18 10 0,000 0,05138896 0,08459786 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,05138896 0,0845409 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05138896 0,084484 ! melanosome localization GO:0032400 16 10 0,000 0,05138896 0,08442719 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05138896 0,08437045 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,05138896 0,08431379 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05138896 0,0842572 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05138896 0,08420069 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,05138896 0,08414426 ! induction of an organ GO:0001759 17 10 0,000 0,05138896 0,0840879 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05138896 0,08403161 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05138896 0,08397541 ! protein sumoylation GO:0016925 17 10 0,000 0,05138896 0,08391927 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,05138896 0,08386321 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05138896 0,08380723 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05138896 0,08375132 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05138896 0,08369549 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05138896 0,08363973 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05138896 0,08358404 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,05138896 0,08352843 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05138896 0,08347289 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,05138896 0,08341743 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05138896 0,08336204 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,05138896 0,08330672 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05138896 0,08325148 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05138896 0,08319631 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05138896 0,08314121 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,05138896 0,08308619 ! detection of calcium ion GO:0005513 24 10 0,000 0,05138896 0,08303124 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05138896 0,08297636 ! blastocyst formation GO:0001825 18 10 0,000 0,05138896 0,08292155 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05138896 0,08286682 ! cerebellar cortex development GO:0021695 16 10 0,000 0,05138896 0,08281216 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,05138896 0,08275757 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,05138896 0,08270305 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,05138896 0,0826486 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,05138896 0,08259423 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,05401206 0,08675309 ! carbohydrate transport GO:0008643 114 72 1,000 0,05536814 0,08887277 ! B cell activation GO:0042113 179 72 1,000 0,05536814 0,08881442 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,05536814 0,08875614 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,05536814 0,08869794 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,05638109 0,09026147 ! respiratory burst GO:0045730 17 11 0,000 0,05638109 0,09020236 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05638109 0,09014332 ! neuron fate specification GO:0048665 18 11 0,000 0,05638109 0,09008437 ! telencephalon cell migration GO:0022029 23 11 0,000 0,05638109 0,09002549 ! thyroid gland development GO:0030878 26 11 0,000 0,05638109 0,08996669 ! synapsis GO:0007129 14 11 0,000 0,05638109 0,08990796 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05638109 0,08984931 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05638109 0,08979074 ! response to pain GO:0048265 27 11 0,000 0,05638109 0,08973225 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05638109 0,08967383 ! blood vessel remodeling GO:0001974 30 11 0,000 0,05638109 0,08961548 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,05638109 0,08955722 ! bone resorption GO:0045453 16 11 0,000 0,05638109 0,08949902 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05638109 0,08944091 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05638109 0,08938287 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05638109 0,0893249 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05638109 0,08926701 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05638109 0,0892092 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05638109 0,08915146 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05638109 0,08909379 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,05638109 0,0890362 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,05638109 0,08897868 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05638109 0,08892124 ! UV protection GO:0009650 20 11 0,000 0,05638109 0,08886387 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05638109 0,08880658 ! macroautophagy GO:0016236 19 11 0,000 0,05638109 0,08874935 ! temperature homeostasis GO:0001659 18 11 0,000 0,05638109 0,08869221 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05638109 0,08863513 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,05638109 0,08857813 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05638109 0,08852121 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,05638109 0,08846435 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,05638109 0,08840757 ! regulation of organ growth GO:0046620 14 11 0,000 0,05638109 0,08835087 ! pigment granule localization GO:0051875 20 11 0,000 0,05638109 0,08829423 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,05638109 0,08823767 ! vasoconstriction GO:0042310 20 11 0,000 0,05638109 0,08818118 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05638109 0,08812476 ! embryonic axis specification GO:0000578 19 11 0,000 0,05638109 0,08806841 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05638109 0,08801214 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05638109 0,08795594 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05638109 0,08789981 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05638109 0,08784375 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05638109 0,08778776 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05638109 0,08773185 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05638109 0,087676 ! prophase GO:0051324 17 11 0,000 0,05638109 0,08762023 ! neuroblast proliferation GO:0007405 25 11 0,000 0,05638109 0,08756453 ! nucleosome positioning GO:0016584 15 11 0,000 0,05638109 0,08750889 ! regulation of isotype switching GO:0045191 24 11 0,000 0,05638109 0,08745333 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05638109 0,08739784 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05638109 0,08734242 ! apical protein localization GO:0045176 18 11 0,000 0,05638109 0,08728707 ! acid secretion GO:0046717 20 11 0,000 0,05638109 0,08723179 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05638109 0,08717658 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05638109 0,08712144 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,05638109 0,08706637 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05638109 0,08701137 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,05638109 0,08695644 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05638109 0,08690158 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,05638109 0,08684678 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05638109 0,08679206 ! germ cell migration GO:0008354 26 11 0,000 0,05638109 0,0867374 ! embryonic gut development GO:0048566 19 11 0,000 0,05638109 0,08668282 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,05638109 0,0866283 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05638109 0,08657385 ! activation of innate immune response GO:0002218 16 11 0,000 0,05638109 0,08651947 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05638109 0,08646516 ! lysogeny GO:0030069 22 11 0,000 0,05638109 0,08641092 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05638109 0,08635674 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,05638109 0,08630263 ! nucleus localization GO:0051647 22 11 0,000 0,05638109 0,08624859 ! humoral immune response GO:0006959 115 73 1,000 0,05673615 0,08673743 ! organelle localization GO:0051640 155 74 1,000 0,05811593 0,08879125 ! axon guidance GO:0007411 162 75 1,000 0,05950731 0,09086022 ! rhythmic process GO:0048511 142 75 1,000 0,05950731 0,09080347 ! learning or memory GO:0007611 161 76 1,000 0,06091014 0,09288606 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 1,000 0,06091014 0,09282811 ! regulation of blood pressure GO:0008217 134 76 1,000 0,06091014 0,09277024 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06134708 0,09337752 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06134708 0,09331938 ! mating GO:0007618 17 12 0,000 0,06134708 0,09326131 ! protein complex disassembly GO:0043241 28 12 0,000 0,06134708 0,09320331 GO:0043624|cellular protein complex disassembly, ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,06134708 0,09314539 ! hippocampus development GO:0021766 29 12 0,000 0,06134708 0,09308753 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,06134708 0,09302975 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06134708 0,09297204 ! T cell proliferation GO:0042098 32 12 0,000 0,06134708 0,0929144 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06134708 0,09285683 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06134708 0,09279934 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06134708 0,09274191 ! drug transport GO:0015893 16 12 0,000 0,06134708 0,09268456 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06134708 0,09262727 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06134708 0,09257006 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06134708 0,09251292 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06134708 0,09245585 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06134708 0,09239885 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06134708 0,09234191 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06134708 0,09228505 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06134708 0,09222826 ! lipid digestion GO:0044241 21 12 0,000 0,06134708 0,09217154 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06134708 0,09211489 ! entry into host cell GO:0030260 34 12 0,000 0,06134708 0,09205831 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06134708 0,0920018 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06134708 0,09194535 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06134708 0,09188898 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06134708 0,09183268 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06134708 0,09177644 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06134708 0,09172027 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06134708 0,09166418 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06134708 0,09160815 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06134708 0,09155219 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06134708 0,09149629 ! cranial nerve development GO:0021545 23 12 0,000 0,06134708 0,09144047 ! fucose catabolic process GO:0019317 25 12 0,000 0,06134708 0,09138471 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06134708 0,09132902 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,06134708 0,0912734 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06134708 0,09121785 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,06134708 0,09116236 ! zymogen activation GO:0031638 18 12 0,000 0,06134708 0,09110695 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06134708 0,0910516 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06134708 0,09099631 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,06134708 0,0909411 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06134708 0,09088595 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06134708 0,09083086 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,06134708 0,09077585 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06134708 0,0907209 ! defense response to fungus GO:0050832 15 12 0,000 0,06134708 0,09066602 ! developmental induction GO:0031128 22 12 0,000 0,06134708 0,0906112 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,06134708 0,09055645 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06134708 0,09050177 ! response to cold GO:0009409 17 12 0,000 0,06134708 0,09044715 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06134708 0,0903926 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06134708 0,09033811 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,06232426 0,09172178 ! cytosolic calcium ion homeostasis GO:0051480 149 77 1,000 0,06232426 0,09166656 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,06232426 0,09161141 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,06232426 0,09155632 ! regulation of catabolic process GO:0009894 173 77 1,000 0,06232426 0,0915013 ! antigen processing and presentation GO:0019882 117 78 1,000 0,06374951 0,09353757 ! fertilization GO:0009566 99 78 1,000 0,06374951 0,09348142 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,06628708 0,09714418 ! cGMP metabolic process GO:0046068 18 13 0,000 0,06628708 0,09708594 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,06628708 0,09702777 ! regulation of chemokine production GO:0032642 18 13 0,000 0,06628708 0,09696967 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,06628708 0,09691164 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,06628708 0,09685368 ! peroxisomal transport GO:0043574 28 13 0,000 0,06628708 0,09679578 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,06628708 0,09673796 ! cartilage condensation GO:0001502 22 13 0,000 0,06628708 0,09668021 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,06628708 0,09662252 ! organelle fusion GO:0048284 36 13 0,000 0,06628708 0,09656491 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,06628708 0,09650736 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,06628708 0,09644988 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,06628708 0,09639247 ! endocrine pancreas development GO:0031018 25 13 0,000 0,06628708 0,09633513 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,06628708 0,09627785 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,06628708 0,09622065 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,06628708 0,09616351 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,06628708 0,09610644 ! methionine metabolic process GO:0006555 31 13 0,000 0,06628708 0,09604944 ! plasma membrane organization GO:0007009 27 13 0,000 0,06628708 0,0959925 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,06628708 0,09593563 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,06628708 0,09587883 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,06628708 0,0958221 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,06628708 0,09576543 ! cytokine metabolic process GO:0042107 24 13 0,000 0,06628708 0,09570883 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,06628708 0,0956523 ! asymmetric protein localization GO:0008105 24 13 0,000 0,06628708 0,09559584 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,06628708 0,09553944 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,06628708 0,09548311 ! L-glutamate transport GO:0015813 30 13 0,000 0,06628708 0,09542684 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,06628708 0,09537064 ! protein homotetramerization GO:0051289 24 13 0,000 0,06628708 0,09531451 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,06628708 0,09525844 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,06628708 0,09520244 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,06628708 0,0951465 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,06628708 0,09509063 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,06628708 0,09503483 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,06628708 0,09497909 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,06628708 0,09492342 ! histone methylation GO:0016571 29 13 0,000 0,06628708 0,09486781 ! chromatin silencing GO:0006342 29 13 0,000 0,06628708 0,09481226 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,06628708 0,09475679 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,06628708 0,09470137 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,06628708 0,09464602 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,06628708 0,09459074 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,06628708 0,09453552 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,06628708 0,09448037 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,06628708 0,09442528 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,06628708 0,09437025 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,06628708 0,09431529 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,06628708 0,09426039 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,06628708 0,09420555 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,06628708 0,09415078 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,06628708 0,09409608 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,06628708 0,09404143 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,06628708 0,09398685 ! acrosome reaction GO:0007340 19 13 0,000 0,06628708 0,09393234 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,06628708 0,09387788 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,06628708 0,09382349 ! muscle cell differentiation GO:0042692 178 81 1,000 0,06809053 0,0963203 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,06809053 0,09626456 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,0710374 0,10037269 ! rRNA transcription GO:0009303 28 14 0,000 0,07120122 0,10054601 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07120122 0,10048792 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,07120122 0,1004299 ! water transport GO:0006833 21 14 0,000 0,07120122 0,10037195 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07120122 0,10031407 ! non-recombinational repair GO:0000726 29 14 0,000 0,07120122 0,10025625 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07120122 0,1001985 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07120122 0,10014081 ! RNA polyadenylation GO:0043631 32 14 0,000 0,07120122 0,10008319 ! lipid localization GO:0010876 32 14 0,000 0,07120122 0,10002564 GO:0019915|lipid storage, ! regulated secretory pathway GO:0045055 24 14 0,000 0,07120122 0,09996816 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07120122 0,09991074 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07120122 0,09985338 ! arginine metabolic process GO:0006525 21 14 0,000 0,07120122 0,09979609 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07120122 0,09973887 ! regulation of heart rate GO:0002027 25 14 0,000 0,07120122 0,09968171 ! organic alcohol transport GO:0015850 29 14 0,000 0,07120122 0,09962462 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07120122 0,0995676 ! embryo implantation GO:0007566 30 14 0,000 0,07120122 0,09951064 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07120122 0,09945374 ! bone mineralization GO:0030282 18 14 0,000 0,07120122 0,09939691 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07120122 0,09934014 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,07120122 0,09928344 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07120122 0,09922681 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07120122 0,09917024 ! regulation of cellular pH GO:0030641 27 14 0,000 0,07120122 0,09911373 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07120122 0,09905729 ! ribosome assembly GO:0042255 18 14 0,000 0,07120122 0,09900091 ! cerebellum development GO:0021549 23 14 0,000 0,07120122 0,09894459 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07120122 0,09888834 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07120122 0,09883215 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07120122 0,09877603 ! NADP metabolic process GO:0006739 24 14 0,000 0,07120122 0,09871997 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,07120122 0,09866398 ! oxygen transport GO:0015671 22 14 0,000 0,07120122 0,09860805 ! male genitalia development GO:0030539 26 14 0,000 0,07120122 0,09855218 ! regulation of RNA stability GO:0043487 33 14 0,000 0,07120122 0,09849637 ! regulation of axon extension GO:0030516 43 14 0,000 0,07120122 0,09844063 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07120122 0,09838495 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,07120122 0,09832933 ! response to nutrient GO:0007584 135 84 1,000 0,07252625 0,10010262 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,07402518 0,10211378 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,07553403 0,10413637 ! regulation of lyase activity GO:0051339 169 86 1,000 0,07553403 0,10407763 ! lactation GO:0007595 30 15 0,000 0,07608964 0,1047841 ! reproductive cellular process GO:0048610 22 15 0,000 0,07608964 0,10472506 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,07608964 0,1046661 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,07608964 0,1046072 ! superoxide anion generation GO:0042554 22 15 0,000 0,07608964 0,10454836 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,07608964 0,10448959 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,07608964 0,10443089 ! copper ion transport GO:0006825 22 15 0,000 0,07608964 0,10437226 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,07608964 0,10431369 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,07608964 0,10425518 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,07608964 0,10419674 ! sulfate transport GO:0008272 27 15 0,000 0,07608964 0,10413837 ! response to cAMP GO:0051591 25 15 0,000 0,07608964 0,10408006 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,07608964 0,10402182 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,07608964 0,10396364 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,07608964 0,10390553 ! response to hexose stimulus GO:0009746 25 15 0,000 0,07608964 0,10384748 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,07608964 0,1037895 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,07608964 0,10373158 ! vesicle coating GO:0006901 38 15 0,000 0,07608964 0,10367373 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,07608964 0,10361594 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,07608964 0,10355821 ! regulation of exocytosis GO:0017157 26 15 0,000 0,07608964 0,10350055 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,07608964 0,10344295 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,07608964 0,10338542 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,07608964 0,10332795 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,07608964 0,10327055 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,07608964 0,10321321 ! histone deacetylation GO:0016575 24 15 0,000 0,07608964 0,10315593 ! water homeostasis GO:0030104 28 15 0,000 0,07608964 0,10309872 ! cofactor transport GO:0051181 30 15 0,000 0,07608964 0,10304157 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,07608964 0,10298448 ! muscle maintenance GO:0046716 26 15 0,000 0,07608964 0,10292746 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,07608964 0,1028705 ! intestinal absorption GO:0050892 31 15 0,000 0,07608964 0,1028136 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,07608964 0,10275677 ! heme biosynthetic process GO:0006783 33 15 0,000 0,07608964 0,10269999 ! cell killing GO:0001906 32 15 0,000 0,07608964 0,10264329 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,07608964 0,10258664 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,07608964 0,10253005 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,07608964 0,10247353 ! actin filament polymerization GO:0030041 27 15 0,000 0,07608964 0,10241707 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,07608964 0,10236068 ! regulation of protein transport GO:0051223 165 87 1,000 0,07705267 0,10359916 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 1,000 0,07858096 0,10559587 ! amine biosynthetic process GO:0009309 146 88 1,000 0,07858096 0,10553781 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,07858096 0,10547983 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,08011874 0,10748495 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,08095246 0,10854383 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,08095246 0,10848429 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,08095246 0,10842482 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,08095246 0,10836541 ! bone remodeling GO:0046849 28 16 0,000 0,08095246 0,10830606 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,08095246 0,10824678 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,08095246 0,10818756 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08095246 0,10812841 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,08095246 0,10806933 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,08095246 0,1080103 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,08095246 0,10795135 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,08095246 0,10789245 ! startle response GO:0001964 28 16 0,000 0,08095246 0,10783362 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,08095246 0,10777486 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,08095246 0,10771616 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,08095246 0,10765752 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,08095246 0,10759895 ! protein polyubiquitination GO:0000209 41 16 0,000 0,08095246 0,10754044 ! glutamate metabolic process GO:0006536 25 16 0,000 0,08095246 0,10748199 ! response to osmotic stress GO:0006970 27 16 0,000 0,08095246 0,10742361 ! lysosomal transport GO:0007041 31 16 0,000 0,08095246 0,10736529 ! fructose metabolic process GO:0006000 25 16 0,000 0,08095246 0,10730704 ! L-amino acid transport GO:0015807 33 16 0,000 0,08095246 0,10724884 ! stem cell development GO:0048864 46 16 0,000 0,08095246 0,10719071 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08095246 0,10713265 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 36 16 0,000 0,08095246 0,10707464 ! axon cargo transport GO:0008088 46 16 0,000 0,08095246 0,1070167 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,08095246 0,10695882 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,08095246 0,10690101 ! DNA replication initiation GO:0006270 28 16 0,000 0,08095246 0,10684326 ! neuron recognition GO:0008038 40 16 0,000 0,08095246 0,10678556 ! mRNA splice site selection GO:0006376 44 16 0,000 0,08095246 0,10672794 ! tissue regeneration GO:0042246 27 16 0,000 0,08095246 0,10667037 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,08095246 0,10661287 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,08095246 0,10655542 ! biomineral formation GO:0031214 22 16 0,000 0,08095246 0,10649804 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,08095246 0,10644072 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,08095246 0,10638347 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,08095246 0,10632627 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08095246 0,10626914 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,08095246 0,10621207 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,08095246 0,10615505 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,08095246 0,1060981 ! peptide hormone processing GO:0016486 27 16 0,000 0,08095246 0,10604121 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,08322225 0,10895604 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! positive regulation of cell killing GO:0031343 36 17 0,000 0,08578983 0,11225739 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,08578983 0,1121973 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,08578983 0,11213726 ! signal complex assembly GO:0007172 47 17 0,000 0,08578983 0,1120773 ! filopodium assembly GO:0046847 42 17 0,000 0,08578983 0,1120174 ! endothelial cell migration GO:0043542 31 17 0,000 0,08578983 0,11195756 ! gene silencing by RNA GO:0031047 38 17 0,000 0,08578983 0,11189778 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,08578983 0,11183807 ! glial cell development GO:0021782 28 17 0,000 0,08578983 0,11177843 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,08578983 0,11171884 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,08578983 0,11165932 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,08578983 0,11159987 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,08578983 0,11154047 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,08578983 0,11148114 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,08578983 0,11142188 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,08578983 0,11136267 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,08578983 0,11130353 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,08578983 0,11124445 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,08578983 0,11118544 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,08578983 0,11112648 ! NAD metabolic process GO:0019674 33 17 0,000 0,08578983 0,11106759 ! membrane budding GO:0006900 42 17 0,000 0,08578983 0,11100876 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,08578983 0,11095 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,08578983 0,1108913 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,08578983 0,11083265 ! genitalia development GO:0048806 32 17 0,000 0,08578983 0,11077407 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,08578983 0,11071556 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,08578983 0,1106571 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,08578983 0,11059871 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,08578983 0,11054037 ! steroid catabolic process GO:0006706 34 17 0,000 0,08578983 0,1104821 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,08578983 0,11042389 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,08578983 0,11036574 ! gas transport GO:0015669 26 17 0,000 0,08578983 0,11030766 ! organic cation transport GO:0015695 32 17 0,000 0,08578983 0,11024963 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,08578983 0,11019167 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,08578983 0,11013376 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,08636209 0,11081018 ! female pregnancy GO:0007565 166 94 1,000 0,08794529 0,11278233 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,08953716 0,11476353 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,08953716 0,11470335 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,09060187 0,11600648 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,09060187 0,11594571 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,09060187 0,115885 ! limbic system development GO:0021761 40 18 0,000 0,09060187 0,11582436 ! negative regulation of ion transport GO:0043271 25 18 0,000 0,09060187 0,11576379 ! adult walking behavior GO:0007628 36 18 0,000 0,09060187 0,11570327 ! heart looping GO:0001947 34 18 0,000 0,09060187 0,11564282 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,09060187 0,11558243 ! centrosome cycle GO:0007098 26 18 0,000 0,09060187 0,11552211 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,09060187 0,11546185 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,09060187 0,11540165 ! glycine metabolic process GO:0006544 30 18 0,000 0,09060187 0,11534151 ! glutamine metabolic process GO:0006541 29 18 0,000 0,09060187 0,11528144 ! response to retinoic acid GO:0032526 31 18 0,000 0,09060187 0,11522143 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,09060187 0,11516148 ! DNA integration GO:0015074 32 18 0,000 0,09060187 0,11510159 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,09060187 0,11504177 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,09060187 0,114982 ! neural crest cell migration GO:0001755 41 18 0,000 0,09060187 0,1149223 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,09060187 0,11486267 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,09060187 0,11480309 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,09060187 0,11474358 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,09060187 0,11468412 GO:0033014|tetrapyrrole biosynthetic process, ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,09060187 0,11462473 ! detection of bacterium GO:0016045 22 18 0,000 0,09060187 0,1145654 ! nerve development GO:0021675 34 18 0,000 0,09060187 0,11450613 ! microspike assembly GO:0030035 46 18 0,000 0,09060187 0,11444693 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,09060187 0,11438778 ! response to protein stimulus GO:0051789 158 96 1,000 0,09113757 0,11500469 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,09274639 0,1169744 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,09436348 0,11895251 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,09538871 0,12018289 ! positive regulation of translation GO:0045727 31 19 0,000 0,09538871 0,12012094 ! negative regulation of defense response GO:0031348 27 19 0,000 0,09538871 0,12005905 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,09538871 0,11999723 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,09538871 0,11993547 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,09538871 0,11987378 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,09538871 0,11981214 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,09538871 0,11975058 ! inositol metabolic process GO:0006020 33 19 0,000 0,09538871 0,11968907 ! memory GO:0007613 34 19 0,000 0,09538871 0,11962763 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,09538871 0,11956625 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,09538871 0,11950493 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,09538871 0,11944368 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,09538871 0,11938249 ! cerebral cortex development GO:0021987 40 19 0,000 0,09538871 0,11932136 ! response to vitamin A GO:0033189 32 19 0,000 0,09538871 0,1192603 ! heme metabolic process GO:0042168 40 19 0,000 0,09538871 0,11919929 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,09538871 0,11913835 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,09538871 0,11907748 ! response to fungus GO:0009620 26 19 0,000 0,09538871 0,11901666 ! peptide cross-linking GO:0018149 39 19 0,000 0,09538871 0,11895591 ! heart process GO:0003015 32 19 0,000 0,09538871 0,11889521 GO:0060047|heart contraction, ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,09538871 0,11883458 ! visual learning GO:0008542 38 19 0,000 0,09538871 0,11877402 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,09538871 0,11871351 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,09538871 0,11865307 ! vitamin transport GO:0051180 31 19 0,000 0,09538871 0,11859268 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,09538871 0,11853236 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,09538871 0,1184721 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,09538871 0,1184119 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,09538871 0,11835176 ! cilium assembly GO:0042384 38 19 0,000 0,09538871 0,11829169 ! positive regulation of immune response GO:0050778 175 100 1,000 0,09762196 0,12099972 ! hormone metabolic process GO:0042445 171 100 1,000 0,09762196 0,12093836 ! protein secretion GO:0009306 45 20 0,000 0,10015049 0,12400793 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,10015049 0,12394511 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,10015049 0,12388236 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,10015049 0,12381966 ! skin development GO:0043588 42 20 0,000 0,10015049 0,12375703 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,10015049 0,12369447 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,10015049 0,12363196 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,10015049 0,12356952 ! response to vitamin GO:0033273 36 20 0,000 0,10015049 0,12350715 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,10015049 0,12344483 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,10015049 0,12338258 ! bile acid metabolic process GO:0008206 34 20 0,000 0,10015049 0,12332039 ! retinoid metabolic process GO:0001523 34 20 0,000 0,10015049 0,12325826 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,10015049 0,1231962 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,10015049 0,1231342 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,10015049 0,12307226 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,10015049 0,12301038 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,10015049 0,12294857 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,10015049 0,12288682 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,10015049 0,12282513 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,10015049 0,1227635 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,10015049 0,12270193 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,10015049 0,12264043 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,10015049 0,12257899 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,10015049 0,1225176 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,10015049 0,12245628 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,10015049 0,12239502 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,10015049 0,12233383 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,10015049 0,12227269 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,10015049 0,12221162 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,10015049 0,1221506 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,10015049 0,12208965 ! regulation of cell killing GO:0031341 46 21 0,000 0,10488734 0,12780039 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,10488734 0,12773668 ! cAMP metabolic process GO:0046058 41 21 0,000 0,10488734 0,12767303 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,10488734 0,12760945 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,10488734 0,12754593 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,10488734 0,12748248 ! smooth muscle contraction GO:0006939 48 21 0,000 0,10488734 0,12741908 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,10488734 0,12735575 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,10488734 0,12729249 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,10488734 0,12722928 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,10488734 0,12716614 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,10488734 0,12710306 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,10488734 0,12704005 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,10488734 0,1269771 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,10488734 0,1269142 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,10488734 0,12685138 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,10488734 0,12678861 ! sperm-egg recognition GO:0035036 23 21 0,000 0,10488734 0,1267259 ! actin filament-based movement GO:0030048 47 21 0,000 0,10488734 0,12666326 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,10488734 0,12660068 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,10959939 0,13222287 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,10959939 0,13215761 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,10959939 0,13209241 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,10959939 0,13202727 ! microtubule-based transport GO:0010970 59 22 0,000 0,10959939 0,1319622 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,10959939 0,1318972 ! vacuolar transport GO:0007034 41 22 0,000 0,10959939 0,13183226 ! fucose metabolic process GO:0006004 44 22 0,000 0,10959939 0,13176738 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,10959939 0,13170256 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,10959939 0,13163781 ! stem cell differentiation GO:0048863 57 22 0,000 0,10959939 0,13157313 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,10959939 0,1315085 ! cytolysis GO:0019835 27 22 0,000 0,10959939 0,13144394 ! vasodilation GO:0042311 40 22 0,000 0,10959939 0,13137945 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,10959939 0,13131501 ! G1 phase GO:0051318 44 22 0,000 0,10959939 0,13125064 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,10959939 0,13118634 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,10959939 0,13112209 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,10959939 0,13105791 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,10959939 0,13099379 ! sarcomere organization GO:0045214 32 22 0,000 0,10959939 0,13092974 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,10959939 0,13086574 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,10959939 0,13080181 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,10959939 0,13073794 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,10959939 0,13067414 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,10959939 0,1306104 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,11428676 0,13612997 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,11428676 0,13606363 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,11428676 0,13599735 ! gluconeogenesis GO:0006094 38 23 0,000 0,11428676 0,13593114 ! glycerol metabolic process GO:0006071 40 23 0,000 0,11428676 0,135865 ! viral genome replication GO:0019079 44 23 0,000 0,11428676 0,13579891 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,11428676 0,1357329 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,11428676 0,13566694 ! axis specification GO:0009798 43 23 0,000 0,11428676 0,13560105 ! visual behavior GO:0007632 46 23 0,000 0,11428676 0,13553523 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,11428676 0,13546946 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,11428676 0,13540377 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,11428676 0,13533813 ! peroxisome organization GO:0007031 43 23 0,000 0,11428676 0,13527256 ! lysosome organization GO:0007040 47 23 0,000 0,11428676 0,13520705 ! vesicle targeting GO:0006903 49 23 0,000 0,11428676 0,13514161 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,11428676 0,13507623 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,11428676 0,13501091 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,11428676 0,13494566 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,11428676 0,13488047 ! fatty acid transport GO:0015908 47 23 0,000 0,11428676 0,13481534 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,11428676 0,13475027 ! cell-cell recognition GO:0009988 28 23 0,000 0,11428676 0,13468527 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,11428676 0,13462033 ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,11428676 0,13455545 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,11894959 0,13997777 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,11894959 0,13991038 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,11894959 0,13984305 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,11894959 0,13977579 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,11894959 0,13970859 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,11894959 0,13964145 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,11894959 0,13957438 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,11894959 0,13950737 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,11894959 0,13944043 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,11894959 0,13937355 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,11894959 0,13930674 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,11894959 0,13923999 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,11894959 0,1391733 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,11894959 0,13910668 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,11894959 0,13904012 ! membrane depolarization GO:0051899 45 24 0,000 0,11894959 0,13897363 ! pallium development GO:0021543 56 24 0,000 0,11894959 0,1389072 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,11894959 0,13884083 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,11894959 0,13877453 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,11894959 0,13870829 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,11894959 0,13864211 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,11894959 0,13857599 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,11894959 0,13850994 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,11894959 0,13844395 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,11894959 0,13837803 ! regulation of amine transport GO:0051952 41 24 0,000 0,11894959 0,13831217 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,12358801 0,14363725 ! leukocyte adhesion GO:0007159 55 25 0,000 0,12358801 0,14356895 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,12358801 0,14350071 ! phototransduction GO:0007602 37 25 0,000 0,12358801 0,14343254 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,12358801 0,14336444 ! vacuole organization GO:0007033 49 25 0,000 0,12358801 0,14329639 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,12358801 0,14322842 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,12358801 0,1431605 ! receptor metabolic process GO:0043112 53 25 0,000 0,12358801 0,14309266 ! chromosome condensation GO:0030261 48 25 0,000 0,12358801 0,14302487 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,12358801 0,14295715 ! immunoglobulin production GO:0002377 62 25 0,000 0,12358801 0,14288949 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,12358801 0,1428219 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,12358801 0,14275437 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,12820213 0,14801409 ! initiation of viral infection GO:0019059 60 26 0,000 0,12820213 0,14794417 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,12820213 0,14787432 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,12820213 0,14780453 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,12820213 0,14773481 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,12820213 0,14766516 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,12820213 0,14759557 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,12820213 0,14752605 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,12820213 0,14745659 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,12820213 0,1473872 ! digestive system process GO:0022600 49 26 0,000 0,12820213 0,14731788 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,12820213 0,14724862 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,12820213 0,14717942 ! osteoblast differentiation GO:0001649 63 26 0,000 0,12820213 0,14711029 ! neural crest cell development GO:0014032 59 26 0,000 0,12820213 0,14704122 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 0,000 0,12820213 0,14697222 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,12820213 0,14690329 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,12820213 0,14683441 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,12820213 0,14676561 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,12820213 0,14669686 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,12820213 0,14662819 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,12820213 0,14655957 ! blastocyst development GO:0001824 50 26 0,000 0,12820213 0,14649102 ! telomere organization GO:0032200 46 26 0,000 0,12820213 0,14642254 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,12820213 0,14635411 ! neural tube closure GO:0001843 58 26 0,000 0,12820213 0,14628576 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,12820213 0,14621746 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,12820213 0,14614923 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,12820213 0,14608107 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,13279209 0,1512406 ! embryonic pattern specification GO:0009880 49 27 0,000 0,13279209 0,15117012 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,13279209 0,15109971 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,13279209 0,15102937 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,13279209 0,15095909 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,13279209 0,15088887 ! iron ion transport GO:0006826 65 27 0,000 0,13279209 0,15081873 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,13279209 0,15074864 ! superoxide metabolic process GO:0006801 41 27 0,000 0,13279209 0,15067862 ! tube lumen formation GO:0035148 59 27 0,000 0,13279209 0,15060867 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,13279209 0,15053878 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,13279209 0,15046896 ! neuron fate commitment GO:0048663 52 28 0,000 0,13735801 0,15557053 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,13735801 0,15549844 ! vesicle docking GO:0048278 55 28 0,000 0,13735801 0,15542641 ! circadian rhythm GO:0007623 56 28 0,000 0,13735801 0,15535446 ! fat cell differentiation GO:0045444 57 28 0,000 0,13735801 0,15528257 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,13735801 0,15521074 ! sperm motility GO:0030317 37 28 0,000 0,13735801 0,15513899 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,13735801 0,1550673 ! base-excision repair GO:0006284 41 28 0,000 0,13735801 0,15499567 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,13735801 0,15492411 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,13735801 0,15485262 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,13735801 0,15478119 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,13735801 0,15470983 ! glutathione metabolic process GO:0006749 42 28 0,000 0,13735801 0,15463854 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,13735801 0,15456731 ! lipid oxidation GO:0034440 48 28 0,000 0,13735801 0,15449615 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,13735801 0,15442505 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,13735801 0,15435401 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,14190002 0,15938472 ! translational initiation GO:0006413 66 29 0,000 0,14190002 0,15931147 ! autophagy GO:0006914 47 29 0,000 0,14190002 0,15923829 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,14190002 0,15916518 ! primary neural tube formation GO:0014020 61 29 0,000 0,14190002 0,15909213 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,14190002 0,15901916 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,14190002 0,15894624 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,14190002 0,1588734 ! synaptogenesis GO:0007416 46 29 0,000 0,14190002 0,15880062 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,14190002 0,15872791 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,14190002 0,15865527 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,14641825 0,1636321 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,14641825 0,16355728 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,14641825 0,16348253 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,14641825 0,16340785 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,14641825 0,16333323 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,14641825 0,16325868 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,14641825 0,16318421 ! acute-phase response GO:0006953 50 30 0,000 0,14641825 0,16310979 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,14641825 0,16303545 ! myofibril assembly GO:0030239 50 30 0,000 0,14641825 0,16296117 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,14641825 0,16288697 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,14641825 0,16281283 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,14641825 0,16273875 ! cell fate determination GO:0001709 64 30 0,000 0,14641825 0,16266475 ! phospholipid transport GO:0015914 65 30 0,000 0,14641825 0,16259081 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,14641825 0,16251694 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,14641825 0,16244313 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,14641825 0,1623694 ! regulation of coagulation GO:0050818 52 30 0,000 0,14641825 0,16229573 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,15091281 0,16720181 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,15091281 0,16712601 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,15091281 0,16705029 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,15091281 0,16697463 ! regulation of innate immune response GO:0045088 57 31 0,000 0,15091281 0,16689904 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,15091281 0,16682352 ! detection of light stimulus GO:0009583 44 31 0,000 0,15091281 0,16674807 ! natural killer cell activation GO:0030101 50 31 0,000 0,15091281 0,16667269 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,15091281 0,16659737 ! eye morphogenesis GO:0048592 65 31 0,000 0,15091281 0,16652213 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,15091281 0,16644695 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,15538383 0,17130085 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,15538383 0,17122358 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,15538383 0,17114639 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,15538383 0,17106926 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,15538383 0,1709922 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,15538383 0,17091521 ! muscle cell development GO:0055001 52 32 0,000 0,15538383 0,17083829 ! mesoderm formation GO:0001707 73 32 0,000 0,15538383 0,17076144 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,15538383 0,17068466 ! gene silencing GO:0016458 71 32 0,000 0,15538383 0,17060795 ! regulation of pH GO:0006885 56 33 0,000 0,15983143 0,17541248 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,15983143 0,17533371 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,15983143 0,17525502 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,15983143 0,17517639 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,15983143 0,17509784 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,15983143 0,17501935 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,15983143 0,17494094 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,15983143 0,1748626 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,15983143 0,17478432 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,15983143 0,17470612 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,15983143 0,17462799 ! glial cell differentiation GO:0010001 67 34 0,000 0,16425573 0,17938165 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,16425573 0,1793015 ! cholesterol transport GO:0030301 62 34 0,000 0,16425573 0,17922142 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,16425573 0,17914141 ! spliceosome assembly GO:0000245 75 34 0,000 0,16425573 0,17906147 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,16425573 0,1789816 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,16425573 0,17890181 ! formation of primary germ layer GO:0001704 76 34 0,000 0,16425573 0,17882208 ! cell fate specification GO:0001708 56 34 0,000 0,16425573 0,17874243 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,16425573 0,17866285 ! adult locomotory behavior GO:0008344 62 34 0,000 0,16425573 0,17858334 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,16865686 0,1832868 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,16865686 0,1832053 ! negative regulation of secretion GO:0051048 68 35 0,000 0,16865686 0,18312388 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,16865686 0,18304252 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,16865686 0,18296124 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,16865686 0,18288004 ! membrane docking GO:0022406 69 35 0,000 0,16865686 0,1827989 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,16865686 0,18271784 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,16865686 0,18263684 ! ceramide metabolic process GO:0006672 72 35 0,000 0,16865686 0,18255592 ! telencephalon development GO:0021537 81 35 0,000 0,16865686 0,18247508 ! sterol transport GO:0015918 63 35 0,000 0,16865686 0,1823943 ! vesicle localization GO:0051648 70 35 0,000 0,16865686 0,18231359 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,17303494 0,18696345 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,17303494 0,1868808 ! protein targeting to membrane GO:0006612 75 36 0,000 0,17303494 0,18679822 ! regulation of proteolysis GO:0030162 77 36 0,000 0,17303494 0,18671571 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,17303494 0,18663327 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,17303494 0,18655091 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,17739009 0,19116188 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,17739009 0,19107759 ! actomyosin structure organization GO:0031032 68 37 0,000 0,17739009 0,19099338 ! tissue remodeling GO:0048771 78 37 0,000 0,17739009 0,19090924 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,17739009 0,19082518 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,17739009 0,19074119 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,18172242 0,19531362 ! organic anion transport GO:0015711 82 38 0,000 0,18172242 0,19522773 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,18172242 0,19514192 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,18172242 0,19505618 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,18172242 0,19497052 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,18172242 0,19488493 ! neural tube formation GO:0001841 79 38 0,000 0,18172242 0,19479941 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,18603205 0,19933171 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,18603205 0,19924432 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,18603205 0,19915701 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,18603205 0,19906978 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,18603205 0,19898262 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,18603205 0,19889554 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,19031911 0,20339002 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,19031911 0,20330109 ! learning GO:0007612 82 40 0,000 0,19031911 0,20321223 ! mismatch repair GO:0006298 58 40 0,000 0,19031911 0,20312345 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,19031911 0,20303475 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,19031911 0,20294613 ! RNA export from nucleus GO:0006405 61 41 0,000 0,19458371 0,20740314 ! mRNA catabolic process GO:0006402 79 41 0,000 0,19458371 0,20731269 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,19458371 0,20722232 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,19458371 0,20713203 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,19458371 0,20704181 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,19458371 0,20695168 ! feeding behavior GO:0007631 69 41 0,000 0,19458371 0,20686162 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,19458371 0,20677164 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,19458371 0,20668174 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,19458371 0,20659192 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,19458371 0,20650217 ! RNA modification GO:0009451 64 41 0,000 0,19458371 0,20641251 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,19882597 0,21082111 ! organic ether metabolic process GO:0018904 59 42 0,000 0,19882597 0,21072965 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,19882597 0,21063826 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,19882597 0,21054696 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,19882597 0,21045574 ! regulation of protein secretion GO:0050708 77 42 0,000 0,19882597 0,21036459 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,19882597 0,21027352 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,19882597 0,21018253 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,203046 0,21455077 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,203046 0,21445801 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,203046 0,21436533 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,203046 0,21427273 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,203046 0,21418021 ! ion transmembrane transport GO:0034220 79 43 0,000 0,203046 0,21408777 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,203046 0,21399542 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,20724392 0,21832553 ! striated muscle contraction GO:0006941 85 44 0,000 0,20724392 0,21823142 ! phagocytosis GO:0006909 105 44 0,000 0,20724392 0,2181374 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,20724392 0,21804345 ! double-strand break repair GO:0006302 85 44 0,000 0,20724392 0,21794959 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,21141985 0,22224556 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,21141985 0,22214997 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,21141985 0,22205446 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,21141985 0,22195904 ! polyol metabolic process GO:0019751 77 45 0,000 0,21141985 0,2218637 ! maintenance of location in cell GO:0051651 101 45 0,000 0,21141985 0,22176843 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,21557389 0,22602876 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,21557389 0,2259318 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,21557389 0,22583491 ! neural tube development GO:0021915 91 47 0,000 0,21970617 0,23006523 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,21970617 0,22996666 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,2238168 0,23416893 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,2238168 0,23406868 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,2238168 0,23396852 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,2238168 0,23386845 ! regulation of ion transport GO:0043269 86 50 0,000 0,23197355 0,24228789 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,23197355 0,24218435 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,23197355 0,2420809 GO:0019724|B cell mediated immunity, ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,23197355 0,24197753 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,23601989 0,2460933 ! viral infectious cycle GO:0019058 104 51 0,000 0,23601989 0,24598831 ! peptide metabolic process GO:0006518 80 51 0,000 0,23601989 0,24588341 ! Notch signaling pathway GO:0007219 111 52 0,000 0,24004503 0,24997017 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,24004503 0,24986366 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,24004503 0,24975725 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,24004503 0,24965092 ! excretion GO:0007588 87 52 0,000 0,24004503 0,24954469 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,24004503 0,24943854 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,24004503 0,24933249 ! amino acid activation GO:0043038 98 52 0,000 0,24004503 0,24922652 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,24404908 0,25327608 ! inner ear development GO:0048839 89 53 0,000 0,24404908 0,25316853 ! chromatin remodeling GO:0006338 122 53 0,000 0,24404908 0,25306108 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,24404908 0,25295371 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,24404908 0,25284644 ! regulation of translational initiation GO:0006446 87 54 0,000 0,24803214 0,25686414 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,24803214 0,2567553 ! neuromuscular process GO:0050905 107 54 0,000 0,24803214 0,25664655 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,24803214 0,2565379 ! regulation of cell shape GO:0008360 142 54 0,000 0,24803214 0,25642933 ! RNA catabolic process GO:0006401 103 55 0,000 0,25199432 0,26041545 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,25199432 0,26030534 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,25199432 0,26019532 ! cell recognition GO:0008037 98 55 0,000 0,25199432 0,2600854 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,25199432 0,25997556 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,25593574 0,26393036 ! chloride transport GO:0006821 102 57 0,000 0,25985651 0,26786053 ! regulation of actin filament length GO:0030832 118 58 0,000 0,26375672 0,2717662 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,26375672 0,27165163 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,26375672 0,27153715 ! gastrulation GO:0007369 122 58 0,000 0,26375672 0,27142277 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,27149592 0,27926928 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,27149592 0,27915174 ! adult behavior GO:0030534 104 60 0,000 0,27149592 0,2790343 ! positive regulation of secretion GO:0051047 110 61 0,000 0,27533512 0,28286111 ! regulation of cellular component size GO:0032535 125 61 0,000 0,27533512 0,28274221 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,27533512 0,28262341 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,27533512 0,28250471 ! proton transport GO:0015992 117 61 0,000 0,27533512 0,28238611 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,2791542 0,28618284 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,2791542 0,2860628 ! tRNA processing GO:0008033 102 62 0,000 0,2791542 0,28594286 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,28295326 0,28971283 ! mesoderm development GO:0007498 128 63 0,000 0,28295326 0,28959146 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,28295326 0,28947019 ! hydrogen transport GO:0006818 121 64 0,000 0,2867324 0,29321359 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,2867324 0,2930909 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,2867324 0,29296832 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,29049173 0,29668533 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,29049173 0,29656135 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,29049173 0,29643747 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,29423135 0,30012827 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,29795137 0,30379599 ! adaptive immune response GO:0002250 126 68 0,000 0,30165188 0,30744078 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,30533299 0,31106276 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,30533299 0,3109331 ! cell redox homeostasis GO:0045454 114 70 0,000 0,3089948 0,31453096 ! activation of immune response GO:0002253 120 70 0,000 0,3089948 0,31439996 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,3089948 0,31426907 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,31263742 0,31784153 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,31626093 0,32139161 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,31626093 0,32125798 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,31986544 0,3247844 ! regulation of immune effector process GO:0002697 156 73 0,000 0,31986544 0,32464946 ! acute inflammatory response GO:0002526 118 74 0,000 0,32345105 0,32815237 ! amino acid transport GO:0006865 148 74 0,000 0,32345105 0,32801615 ! transition metal ion transport GO:0000041 143 75 0,000 0,32701785 0,33149569 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,32701785 0,3313582 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,33056596 0,33481452 ! amine catabolic process GO:0009310 136 77 0,000 0,33409545 0,33824915 ! neurotransmitter transport GO:0006836 142 77 0,000 0,33409545 0,33810903 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,33760644 0,34152072 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,34109901 0,34491096 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,34109901 0,34476826 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,34109901 0,34462568 ! exocytosis GO:0006887 153 83 0,000 0,35488709 0,35840808 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,35488709 0,35825998 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,35488709 0,358112 ! inorganic anion transport GO:0015698 156 83 0,000 0,35488709 0,35796414 ! digestion GO:0007586 130 84 0,000 0,35828902 0,36124642 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,36167312 0,36450801 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,36838814 0,37112257 ! nucleosome assembly GO:0006334 126 87 0,000 0,36838814 0,37096959 ! sensory perception of smell GO:0007608 117 88 0,000 0,37171926 0,37416982 ! chromatin assembly GO:0031497 128 88 0,000 0,37171926 0,37401571 ! cellular defense response GO:0006968 123 89 0,000 0,3750329 0,37719447 ! regulation of neurological system process GO:0031644 175 89 0,000 0,3750329 0,37703925 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,37832916 0,38019668 ! response to unfolded protein GO:0006986 139 90 0,000 0,37832916 0,38004035 ! defense response to bacterium GO:0042742 112 91 0,000 0,38160813 0,38317659 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,38486989 0,38629299 ! amine transport GO:0015837 181 93 0,000 0,38811454 0,38938966 ! vitamin metabolic process GO:0006766 153 93 0,000 0,38811454 0,38922981 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,39134217 0,39230567 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,39134217 0,39214475 ! nucleosome organization GO:0034728 143 95 0,000 0,39455286 0,39519993 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,39455286 0,39503796 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,39455286 0,39487613 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,39455286 0,39471443 ! mRNA transport GO:0051028 185 100 0,000 0,41035537 0,41035537