pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6607-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! cell-substrate junction assembly GO:0007044 11 10 3,000 3,568E-07 6,575E-04 ! insulin receptor signaling pathway GO:0008286 17 15 3,000 2,263E-06 2,085E-03 ! response to peptide hormone stimulus GO:0043434 36 34 4,000 2,574E-06 1,581E-03 ! integrin-mediated signaling pathway GO:0007229 36 36 4,000 3,452E-06 1,591E-03 ! cell junction assembly GO:0034329 18 17 3,000 3,907E-06 1,44E-03 ! cell-matrix adhesion GO:0007160 39 38 4,000 4,551E-06 1,398E-03 ! focal adhesion formation GO:0048041 7 6 2,000 5,518E-06 1,453E-03 ! peptidyl-serine phosphorylation GO:0018105 6 6 2,000 5,518E-06 1,271E-03 ! cell-substrate adhesion GO:0031589 43 42 4,000 7,561E-06 1,548E-03 ! cellular response to insulin stimulus GO:0032869 23 21 3,000 9,635E-06 1,776E-03 ! cell junction organization GO:0034330 23 22 3,000 1,172E-05 1,963E-03 ! T cell selection GO:0045058 8 8 2,000 1,53E-05 2,351E-03 ! peptidyl-serine modification GO:0018209 8 8 2,000 1,53E-05 2,17E-03 ! gland development GO:0048732 51 49 4,000 1,637E-05 2,155E-03 ! T cell differentiation GO:0030217 24 24 3,000 1,686E-05 2,071E-03 ! regulation of DNA metabolic process GO:0051052 51 50 4,000 1,81E-05 2,084E-03 ! T cell differentiation in the thymus GO:0033077 9 9 2,000 2,285E-05 2,477E-03 ! defense response to virus GO:0051607 9 9 2,000 2,285E-05 2,34E-03 ! response to insulin stimulus GO:0032868 28 26 3,000 2,349E-05 2,278E-03 ! peptidyl-amino acid modification GO:0018193 61 59 4,000 4,089E-05 3,768E-03 ! hindbrain development GO:0030902 11 11 2,000 4,446E-05 3,902E-03 ! regulation of DNA replication GO:0006275 32 31 3,000 4,824E-05 4,041E-03 ! tissue homeostasis GO:0001894 13 13 2,000 7,635E-05 6,118E-03 GO:0048871|multicellular organismal homeostasis, ! regulation of mitotic cell cycle GO:0007346 72 69 4,000 8,733E-05 6,706E-03 ! nucleotide-excision repair GO:0006289 40 39 3,000 1,213E-04 8,939E-03 ! lymphocyte differentiation GO:0030098 39 39 3,000 1,213E-04 8,595E-03 ! lymphocyte proliferation GO:0046651 16 16 2,000 1,474E-04 0,01006213 ! positive regulation of catabolic process GO:0009896 16 16 2,000 1,474E-04 9,703E-03 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 2,000 1,782E-04 0,01132245 ! leukocyte adhesion GO:0007159 17 17 2,000 1,782E-04 0,01094504 ! pigmentation GO:0043473 17 17 2,000 1,782E-04 0,01059197 ! mononuclear cell proliferation GO:0032943 18 18 2,000 2,128E-04 0,01225559 GO:0070661|leukocyte proliferation, ! cellular response to hormone stimulus GO:0032870 48 46 3,000 2,325E-04 0,01298429 ! heart development GO:0007507 90 87 4,000 2,625E-04 0,01423107 ! regulation of cell cycle process GO:0010564 50 48 3,000 2,745E-04 0,01445585 ! leukocyte differentiation GO:0002521 50 49 3,000 2,975E-04 0,01522908 ! positive regulation of MAP kinase activity GO:0043406 50 49 3,000 2,975E-04 0,01481748 ! brain development GO:0007420 91 90 4,000 3,076E-04 0,0149209 ! T cell activation GO:0042110 51 50 3,000 3,218E-04 0,01520565 ! positive regulation of DNA metabolic process GO:0051054 23 22 2,000 3,941E-04 0,01816001 ! positive regulation of glucose metabolic process GO:0010907 5 5 1,000 4,318E-04 0,01941029 ! prostate gland development GO:0030850 5 5 1,000 4,318E-04 0,01894814 ! metencephalon development GO:0022037 5 5 1,000 4,318E-04 0,01850749 ! positive regulation of B cell proliferation GO:0030890 5 5 1,000 4,318E-04 0,01808686 ! memory GO:0007613 5 5 1,000 4,318E-04 0,01768493 ! endocrine pancreas development GO:0031018 5 5 1,000 4,318E-04 0,01730048 ! thymic T cell selection GO:0045061 5 5 1,000 4,318E-04 0,01693238 ! pituitary gland development GO:0021983 5 5 1,000 4,318E-04 0,01657962 ! fear response GO:0042596 5 5 1,000 4,318E-04 0,01624126 ! actin cytoskeleton reorganization GO:0031532 5 5 1,000 4,318E-04 0,01591644 ! wound healing, spreading of epidermal cells GO:0035313 5 5 1,000 4,318E-04 0,01560435 ! protein heterooligomerization GO:0051291 5 5 1,000 4,318E-04 0,01530427 ! response to UV-B GO:0010224 5 5 1,000 4,318E-04 0,01501551 ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 4,318E-04 0,01473744 ! cellular pigmentation GO:0033059 5 5 1,000 4,318E-04 0,01446949 ! DNA methylation GO:0006306 5 5 1,000 4,318E-04 0,01421111 GO:0006305|DNA alkylation, ! T cell lineage commitment GO:0002360 5 5 1,000 4,318E-04 0,01396179 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 1,000 4,318E-04 0,01372107 GO:0002714|positive regulation of B cell mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 1,000 4,318E-04 0,01348851 ! regulation of DNA replication initiation GO:0030174 5 5 1,000 4,318E-04 0,0132637 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 1,000 4,318E-04 0,01304626 GO:0002820|negative regulation of adaptive immune response, ! peptidyl-lysine modification GO:0018205 5 5 1,000 4,318E-04 0,01283584 ! regulation of isotype switching GO:0045191 5 5 1,000 4,318E-04 0,01263209 ! oocyte differentiation GO:0009994 5 5 1,000 4,318E-04 0,01243472 GO:0048599|oocyte development, ! regulation of protein homodimerization activity GO:0043496 6 5 1,000 4,318E-04 0,01224341 ! spleen development GO:0048536 5 5 1,000 4,318E-04 0,01205791 ! B cell receptor signaling pathway GO:0050853 5 5 1,000 4,318E-04 0,01187794 ! response to nicotine GO:0035094 5 5 1,000 4,318E-04 0,01170326 ! protein amino acid dephosphorylation GO:0006470 55 54 3,000 4,333E-04 0,01157406 ! endocrine system development GO:0035270 23 23 2,000 4,511E-04 0,01187797 ! positive regulation of growth GO:0045927 23 23 2,000 4,511E-04 0,01171068 ! reproductive developmental process GO:0003006 56 56 3,000 4,984E-04 0,01275688 ! response to hormone stimulus GO:0009725 102 100 4,000 5,015E-04 0,0126603 ! regulation of protein localization GO:0032880 58 57 3,000 5,334E-04 0,01328394 ! regulation of gene-specific transcription GO:0032583 25 25 2,000 5,804E-04 0,01426338 ! regulation of intracellular protein transport GO:0033157 25 25 2,000 5,804E-04 0,01407571 ! regulation of T cell proliferation GO:0042129 25 25 2,000 5,804E-04 0,01389291 ! negative regulation of immune system process GO:0002683 25 25 2,000 5,804E-04 0,01371479 ! dephosphorylation GO:0016311 60 59 3,000 6,086E-04 0,01419781 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 6,45E-04 0,0148581 GO:0018409|peptide or protein amino-terminal blocking, ! virus-host interaction GO:0019048 6 6 1,000 6,45E-04 0,01467467 ! regulation of S phase GO:0033261 6 6 1,000 6,45E-04 0,01449571 ! regulation of B cell proliferation GO:0030888 6 6 1,000 6,45E-04 0,01432106 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 1,000 6,45E-04 0,01415058 ! L-serine metabolic process GO:0006563 6 6 1,000 6,45E-04 0,0139841 ! ER overload response GO:0006983 6 6 1,000 6,45E-04 0,01382149 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 6,45E-04 0,01366262 GO:0070667|negative regulation of mast cell proliferation, ! negative regulation of ossification GO:0030279 6 6 1,000 6,45E-04 0,01350737 ! positive regulation of T cell mediated immunity GO:0002711 6 6 1,000 6,45E-04 0,0133556 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 6,45E-04 0,0132072 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 6,45E-04 0,01306207 ! diencephalon development GO:0021536 6 6 1,000 6,45E-04 0,01292009 ! serine family amino acid biosynthetic process GO:0009070 6 6 1,000 6,45E-04 0,01278116 ! thymus development GO:0048538 6 6 1,000 6,45E-04 0,0126452 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 1,000 6,45E-04 0,01251209 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! regulation of embryonic development GO:0045995 6 6 1,000 6,45E-04 0,01238175 ! negative regulation of immune effector process GO:0002698 6 6 1,000 6,45E-04 0,01225411 ! negative regulation of cell migration GO:0030336 26 26 2,000 6,531E-04 0,01228205 ! regulation of T cell differentiation GO:0045580 26 26 2,000 6,531E-04 0,01215799 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 2,000 7,313E-04 0,01347776 ! learning or memory GO:0007611 28 27 2,000 7,313E-04 0,01334432 ! axonogenesis GO:0007409 66 62 3,000 7,351E-04 0,01328254 ! histone modification GO:0016570 28 28 2,000 8,152E-04 0,01458704 ! protein amino acid autophosphorylation GO:0046777 28 28 2,000 8,152E-04 0,01444678 ! regulation of mast cell proliferation GO:0070666 28 28 2,000 8,152E-04 0,01430919 ! positive regulation of cellular catabolic process GO:0031331 7 7 1,000 8,991E-04 0,01563229 ! hair follicle morphogenesis GO:0031069 7 7 1,000 8,991E-04 0,01548619 ! digestive system development GO:0055123 7 7 1,000 8,991E-04 0,0153428 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! regulation of mRNA processing GO:0050684 7 7 1,000 8,991E-04 0,01520204 ! regulation of skeletal muscle fiber development GO:0048742 7 7 1,000 8,991E-04 0,01506384 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 8,991E-04 0,01492813 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 1,000 8,991E-04 0,01479485 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! alpha-beta T cell differentiation GO:0046632 7 7 1,000 8,991E-04 0,01466392 ! axon cargo transport GO:0008088 7 7 1,000 8,991E-04 0,01453529 ! response to gamma radiation GO:0010332 8 7 1,000 8,991E-04 0,01440889 ! regulation of ATPase activity GO:0043462 7 7 1,000 8,991E-04 0,01428468 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 1,000 8,991E-04 0,01416259 ! T cell receptor signaling pathway GO:0050852 7 7 1,000 8,991E-04 0,01404257 ! negative regulation of T cell activation GO:0050868 7 7 1,000 8,991E-04 0,01392456 ! response to cold GO:0009409 7 7 1,000 8,991E-04 0,01380852 ! regulation of lymphocyte proliferation GO:0050670 29 29 2,000 9,051E-04 0,01378518 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! regulation of gene expression, epigenetic GO:0040029 29 29 2,000 9,051E-04 0,01367219 ! covalent chromatin modification GO:0016569 29 29 2,000 9,051E-04 0,01356103 ! regulation of MAP kinase activity GO:0043405 67 66 3,000 9,314E-04 0,01384363 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 3,000 9,857E-04 0,01453386 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! response to reactive oxygen species GO:0000302 31 30 2,000 1,001E-03 0,01464045 ! response to temperature stimulus GO:0009266 30 30 2,000 1,001E-03 0,01452517 ! regulation of intracellular transport GO:0032386 31 31 2,000 1,103E-03 0,01588139 ! negative regulation of cell motion GO:0051271 31 31 2,000 1,103E-03 0,01575827 ! cell part morphogenesis GO:0032990 75 70 3,000 1,162E-03 0,01647489 ! wound healing GO:0042060 74 70 3,000 1,162E-03 0,01634913 ! regulation of skeletal muscle tissue development GO:0048641 8 8 1,000 1,194E-03 0,01666637 ! positive regulation of cell killing GO:0031343 8 8 1,000 1,194E-03 0,01654106 ! negative regulation of bone remodeling GO:0046851 8 8 1,000 1,194E-03 0,01641762 ! embryonic forelimb morphogenesis GO:0035115 8 8 1,000 1,194E-03 0,01629601 ! pancreas development GO:0031016 8 8 1,000 1,194E-03 0,01617619 ! sex determination GO:0007530 8 8 1,000 1,194E-03 0,01605811 ! negative regulation of mitotic cell cycle GO:0045930 9 8 1,000 1,194E-03 0,01594175 ! alpha-beta T cell activation GO:0046631 8 8 1,000 1,194E-03 0,01582706 ! regulation of T cell mediated immunity GO:0002709 8 8 1,000 1,194E-03 0,01571401 ! T cell homeostasis GO:0043029 8 8 1,000 1,194E-03 0,01560256 ! regulation of immunoglobulin production GO:0002637 8 8 1,000 1,194E-03 0,01549269 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 1,000 1,194E-03 0,01538434 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 1,194E-03 0,01527751 ! regulation of lymphocyte differentiation GO:0045619 32 32 2,000 1,211E-03 0,01539758 ! regulation of cell migration GO:0030334 71 71 3,000 1,225E-03 0,01546972 ! calcium ion homeostasis GO:0055074 71 71 3,000 1,225E-03 0,01536448 GO:0006874|cellular calcium ion homeostasis, ! negative regulation of signal transduction GO:0009968 71 71 3,000 1,225E-03 0,01526067 ! regulation of neuron differentiation GO:0045664 34 33 2,000 1,326E-03 0,01640581 ! response to metal ion GO:0010038 34 34 2,000 1,448E-03 0,01779021 ! ear development GO:0043583 34 34 2,000 1,448E-03 0,0176724 ! negative regulation of cell cycle process GO:0010948 9 9 1,000 1,528E-03 0,01852954 ! response to alkaloid GO:0043279 10 9 1,000 1,528E-03 0,01840843 ! response to ethanol GO:0045471 9 9 1,000 1,528E-03 0,01828889 ! activation of pro-apoptotic gene products GO:0008633 9 9 1,000 1,528E-03 0,0181709 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 1,528E-03 0,01805442 GO:0060675|ureteric bud morphogenesis, ! histone acetylation GO:0016573 9 9 1,000 1,528E-03 0,01793942 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 1,000 1,528E-03 0,01782588 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of tissue remodeling GO:0034104 9 9 1,000 1,528E-03 0,01771377 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 1,000 1,528E-03 0,01760306 ! regulation of calcium-mediated signaling GO:0050848 9 9 1,000 1,528E-03 0,01749372 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 2,000 1,576E-03 0,01793276 ! negative regulation of cell communication GO:0010648 76 76 3,000 1,579E-03 0,01785645 ! cellular metal ion homeostasis GO:0006875 77 77 3,000 1,658E-03 0,01862919 ! cell morphogenesis involved in differentiation GO:0000904 82 77 3,000 1,658E-03 0,01851628 ! response to inorganic substance GO:0010035 36 36 2,000 1,712E-03 0,01900267 ! regulation of mitosis GO:0007088 37 36 2,000 1,712E-03 0,01888888 GO:0051783|regulation of nuclear division, ! positive regulation of cell migration GO:0030335 36 36 2,000 1,712E-03 0,01877644 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 2,000 1,712E-03 0,01866534 ! metal ion homeostasis GO:0055065 78 78 3,000 1,739E-03 0,01885121 ! regulation of locomotion GO:0040012 79 79 3,000 1,823E-03 0,0196447 ! regulation of cell motion GO:0051270 79 79 3,000 1,823E-03 0,01953049 ! response to drug GO:0042493 37 37 2,000 1,854E-03 0,01975021 ! lung development GO:0030324 38 37 2,000 1,854E-03 0,01963671 ! regulation of glucose metabolic process GO:0010906 10 10 1,000 1,902E-03 0,02003224 ! regulation of cell killing GO:0031341 10 10 1,000 1,902E-03 0,01991842 ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 1,000 1,902E-03 0,01980589 ! forelimb morphogenesis GO:0035136 10 10 1,000 1,902E-03 0,01969462 ! auditory receptor cell differentiation GO:0042491 10 10 1,000 1,902E-03 0,01958459 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 1,902E-03 0,01947579 ! epidermis morphogenesis GO:0048730 10 10 1,000 1,902E-03 0,01936819 ! plasma membrane organization GO:0007009 10 10 1,000 1,902E-03 0,01926177 ! neuromuscular junction development GO:0007528 10 10 1,000 1,902E-03 0,01915652 ! regulation of protein binding GO:0043393 11 10 1,000 1,902E-03 0,0190524 ! intermediate filament cytoskeleton organization GO:0045104 10 10 1,000 1,902E-03 0,01894942 ! negative regulation of immune response GO:0050777 10 10 1,000 1,902E-03 0,01884754 ! regulation of B cell differentiation GO:0045577 10 10 1,000 1,902E-03 0,01874675 ! histone deacetylation GO:0016575 10 10 1,000 1,902E-03 0,01864703 ! gland morphogenesis GO:0022612 10 10 1,000 1,902E-03 0,01854837 ! negative regulation of neuron differentiation GO:0045665 10 10 1,000 1,902E-03 0,01845075 ! lymphocyte homeostasis GO:0002260 10 10 1,000 1,902E-03 0,01835415 ! gut development GO:0048565 10 10 1,000 1,902E-03 0,01825855 ! negative regulation of homeostatic process GO:0032845 10 10 1,000 1,902E-03 0,01816395 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 1,000 1,902E-03 0,01807032 ! neuron projection development GO:0031175 85 80 3,000 1,909E-03 0,01804559 ! tube development GO:0035295 83 81 3,000 1,999E-03 0,01879456 ! lymphocyte activation GO:0046649 82 81 3,000 1,999E-03 0,01869915 ! urogenital system development GO:0001655 38 38 2,000 2,003E-03 0,01864838 ! RNA elongation GO:0006354 38 38 2,000 2,003E-03 0,01855467 ! regulation of homeostatic process GO:0032844 38 38 2,000 2,003E-03 0,0184619 ! activation of MAPK activity GO:0000187 39 39 2,000 2,16E-03 0,01980823 ! respiratory tube development GO:0030323 40 39 2,000 2,16E-03 0,01971017 ! respiratory system development GO:0060541 40 39 2,000 2,16E-03 0,01961308 ! positive regulation of cell motion GO:0051272 39 39 2,000 2,16E-03 0,01951693 ! G1 phase of mitotic cell cycle GO:0000080 12 11 1,000 2,315E-03 0,02081202 ! microtubule-based transport GO:0010970 11 11 1,000 2,315E-03 0,02071099 ! protein amino acid acetylation GO:0006473 11 11 1,000 2,315E-03 0,02061093 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 1,000 2,315E-03 0,02051184 GO:0032388|positive regulation of intracellular transport, ! T cell proliferation GO:0042098 11 11 1,000 2,315E-03 0,0204137 ! regulation of viral genome replication GO:0045069 11 11 1,000 2,315E-03 0,02031649 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 1,000 2,315E-03 0,02022021 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 1,000 2,315E-03 0,02012483 ! intermediate filament-based process GO:0045103 11 11 1,000 2,315E-03 0,02003034 ! interaction with host GO:0051701 11 11 1,000 2,315E-03 0,01993674 ! oogenesis GO:0048477 11 11 1,000 2,315E-03 0,01984402 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 1,000 2,315E-03 0,01975214 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 1,000 2,315E-03 0,01966112 GO:0006109|regulation of carbohydrate metabolic process, ! proximal/distal pattern formation GO:0009954 11 11 1,000 2,315E-03 0,01957093 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 2,315E-03 0,01948157 ! DNA catabolic process GO:0006308 41 40 2,000 2,325E-03 0,01947382 ! positive regulation of protein kinase activity GO:0045860 89 86 3,000 2,49E-03 0,02076433 ! one-carbon metabolic process GO:0006730 42 42 2,000 2,676E-03 0,02221543 ! positive regulation of transferase activity GO:0051347 91 88 3,000 2,708E-03 0,0223784 GO:0033674|positive regulation of kinase activity, ! positive regulation of protein catabolic process GO:0045732 12 12 1,000 2,766E-03 0,02275895 ! heterophilic cell adhesion GO:0007157 12 12 1,000 2,766E-03 0,0226578 ! male gonad development GO:0008584 12 12 1,000 2,766E-03 0,02255755 ! regulation of alpha-beta T cell activation GO:0046634 12 12 1,000 2,766E-03 0,02245817 ! renal system process GO:0003014 12 12 1,000 2,766E-03 0,02235967 ! cell fate determination GO:0001709 12 12 1,000 2,766E-03 0,02226203 ! regulation of chromosome organization GO:0033044 12 12 1,000 2,766E-03 0,02216524 ! positive regulation of multicellular organism growth GO:0040018 12 12 1,000 2,766E-03 0,02206929 ! somitogenesis GO:0001756 13 12 1,000 2,766E-03 0,02197416 ! G1 phase GO:0051318 13 12 1,000 2,766E-03 0,02187985 ! positive regulation of adaptive immune response GO:0002821 12 12 1,000 2,766E-03 0,02178635 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 1,000 2,766E-03 0,02169364 ! negative regulation of translation GO:0017148 12 12 1,000 2,766E-03 0,02160172 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 1,000 2,766E-03 0,02151057 ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 3,000 2,821E-03 0,02184832 ! reproductive structure development GO:0048608 43 43 2,000 2,863E-03 0,02207971 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 3,000 3,059E-03 0,02348717 ! positive regulation of DNA replication GO:0045740 14 13 1,000 3,255E-03 0,02489349 ! regeneration GO:0031099 13 13 1,000 3,255E-03 0,02479062 ! post-embryonic development GO:0009791 14 13 1,000 3,255E-03 0,02468861 ! negative regulation of protein modification process GO:0031400 13 13 1,000 3,255E-03 0,02458742 ! vasculogenesis GO:0001570 13 13 1,000 3,255E-03 0,02448707 ! regulation of DNA recombination GO:0000018 13 13 1,000 3,255E-03 0,02438752 ! mitochondrial membrane organization GO:0007006 13 13 1,000 3,255E-03 0,02428879 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 1,000 3,255E-03 0,02419085 ! negative regulation of DNA replication GO:0008156 13 13 1,000 3,255E-03 0,0240937 ! response to corticosteroid stimulus GO:0031960 13 13 1,000 3,255E-03 0,02399732 GO:0051384|response to glucocorticoid stimulus, ! actin filament bundle formation GO:0051017 13 13 1,000 3,255E-03 0,02390172 ! ureteric bud development GO:0001657 13 13 1,000 3,255E-03 0,02380687 ! cell aging GO:0007569 13 13 1,000 3,255E-03 0,02371277 ! response to endoplasmic reticulum stress GO:0034976 13 13 1,000 3,255E-03 0,02361941 ! regulation of viral reproduction GO:0050792 13 13 1,000 3,255E-03 0,02352679 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 1,000 3,255E-03 0,02343489 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 1,000 3,255E-03 0,0233437 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 1,000 3,255E-03 0,02325322 ! immunoglobulin production GO:0002377 13 13 1,000 3,255E-03 0,02316344 GO:0002440|production of molecular mediator of immune response, ! negative regulation of intracellular transport GO:0032387 13 13 1,000 3,255E-03 0,02307435 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 3,255E-03 0,02298594 ! regulation of cell-substrate adhesion GO:0010810 14 13 1,000 3,255E-03 0,02289821 GO:0001952|regulation of cell-matrix adhesion, ! response to cytokine stimulus GO:0034097 13 13 1,000 3,255E-03 0,02281114 ! inner ear receptor cell differentiation GO:0060113 13 13 1,000 3,255E-03 0,02272474 ! protein tetramerization GO:0051262 13 13 1,000 3,255E-03 0,02263899 ! phosphoinositide-mediated signaling GO:0048015 45 45 2,000 3,262E-03 0,0225992 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 2,000 3,473E-03 0,02397338 ! regulation of membrane potential GO:0042391 46 46 2,000 3,473E-03 0,02388393 ! sex differentiation GO:0007548 47 47 2,000 3,693E-03 0,02529941 ! regulation of catabolic process GO:0009894 48 47 2,000 3,693E-03 0,02520571 ! neuron fate commitment GO:0048663 14 14 1,000 3,782E-03 0,02571775 ! protein amino acid acylation GO:0043543 14 14 1,000 3,782E-03 0,0256232 ! protein amino acid deacetylation GO:0006476 14 14 1,000 3,782E-03 0,02552934 ! mechanoreceptor differentiation GO:0042490 14 14 1,000 3,782E-03 0,02543617 ! hair cycle GO:0042633 14 14 1,000 3,782E-03 0,02534367 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! positive regulation of epithelial cell proliferation GO:0050679 14 14 1,000 3,782E-03 0,02525185 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 1,000 3,782E-03 0,02516069 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! multicellular organismal response to stress GO:0033555 14 14 1,000 3,782E-03 0,02507018 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 1,000 3,782E-03 0,02498032 GO:0045936|negative regulation of phosphate metabolic process, ! base-excision repair GO:0006284 14 14 1,000 3,782E-03 0,02489111 ! response to organic cyclic substance GO:0014070 15 14 1,000 3,782E-03 0,02480253 ! DNA modification GO:0006304 14 14 1,000 3,782E-03 0,02471458 ! actin filament organization GO:0007015 50 48 2,000 3,921E-03 0,02553185 ! cell cycle arrest GO:0007050 49 49 2,000 4,157E-03 0,02697531 ! skeletal muscle tissue development GO:0007519 50 49 2,000 4,157E-03 0,02688066 GO:0060538|skeletal muscle organ development, ! hemopoiesis GO:0030097 104 100 3,000 4,296E-03 0,0276807 ! ovarian follicle development GO:0001541 15 15 1,000 4,345E-03 0,02790113 ! ER-nuclear signaling pathway GO:0006984 15 15 1,000 4,345E-03 0,02780425 ! response to ionizing radiation GO:0010212 16 15 1,000 4,345E-03 0,02770804 ! regulation of production of molecular mediator of immune response GO:0002700 15 15 1,000 4,345E-03 0,02761249 ! leukocyte homeostasis GO:0001776 15 15 1,000 4,345E-03 0,02751761 ! positive regulation of B cell activation GO:0050871 15 15 1,000 4,345E-03 0,02742337 ! negative regulation of cell activation GO:0050866 15 15 1,000 4,345E-03 0,02732977 ! positive regulation of immune effector process GO:0002699 15 15 1,000 4,345E-03 0,02723681 ! regulation of neurogenesis GO:0050767 51 50 2,000 4,402E-03 0,02749876 ! transcription initiation GO:0006352 50 50 2,000 4,402E-03 0,02740586 ! anatomical structure homeostasis GO:0060249 51 50 2,000 4,402E-03 0,02731358 ! anterior/posterior pattern formation GO:0009952 51 50 2,000 4,402E-03 0,02722193 ! interphase of mitotic cell cycle GO:0051329 52 51 2,000 4,655E-03 0,02869271 GO:0051325|interphase, ! cell fate commitment GO:0045165 52 52 2,000 4,917E-03 0,03020702 ! segmentation GO:0035282 17 16 1,000 4,945E-03 0,03027495 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 1,000 4,945E-03 0,0301747 ! serine family amino acid metabolic process GO:0009069 16 16 1,000 4,945E-03 0,03007511 ! positive regulation of mitosis GO:0045840 16 16 1,000 4,945E-03 0,02997618 GO:0051785|positive regulation of nuclear division, ! cellular response to reactive oxygen species GO:0034614 16 16 1,000 4,945E-03 0,0298779 ! positive regulation of cell development GO:0010720 16 16 1,000 4,945E-03 0,02978026 ! positive regulation of MAPKKK cascade GO:0043410 17 16 1,000 4,945E-03 0,02968325 ! response to hypoxia GO:0001666 53 53 2,000 5,188E-03 0,03104302 ! regulation of T cell activation GO:0050863 53 53 2,000 5,188E-03 0,03094255 ! regulation of protein transport GO:0051223 53 53 2,000 5,188E-03 0,03084274 GO:0070201|regulation of establishment of protein localization, ! response to oxygen levels GO:0070482 55 54 2,000 5,468E-03 0,03240096 ! response to virus GO:0009615 54 54 2,000 5,468E-03 0,03229711 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 1,000 5,58E-03 0,03285627 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 5,58E-03 0,03275163 ! myelination GO:0042552 17 17 1,000 5,58E-03 0,03264766 ! glucose transport GO:0015758 17 17 1,000 5,58E-03 0,03254434 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 5,58E-03 0,03244168 ! response to toxin GO:0009636 18 17 1,000 5,58E-03 0,03233966 ! immune response-activating signal transduction GO:0002757 17 17 1,000 5,58E-03 0,03223829 GO:0002764|immune response-regulating signal transduction, ! liver development GO:0001889 17 17 1,000 5,58E-03 0,03213754 ! microtubule cytoskeleton organization GO:0000226 55 55 2,000 5,756E-03 0,0330486 ! regulation of cell adhesion GO:0030155 56 55 2,000 5,756E-03 0,03294596 ! regulation of nervous system development GO:0051960 57 56 2,000 6,054E-03 0,0345421 ! regulation of cellular catabolic process GO:0031329 18 18 1,000 6,251E-03 0,03555707 ! meiosis I GO:0007127 18 18 1,000 6,251E-03 0,03544767 ! response to calcium ion GO:0051592 18 18 1,000 6,251E-03 0,03533893 ! hexose transport GO:0008645 18 18 1,000 6,251E-03 0,03523086 GO:0015749|monosaccharide transport, ! B cell differentiation GO:0030183 18 18 1,000 6,251E-03 0,03512345 ! ensheathment of neurons GO:0007272 18 18 1,000 6,251E-03 0,03501669 GO:0008366|axon ensheathment, ! regulation of microtubule-based process GO:0032886 18 18 1,000 6,251E-03 0,03491058 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 1,000 6,251E-03 0,03480511 ! regulation of binding GO:0051098 60 57 2,000 6,36E-03 0,03530821 ! activation of adenylate cyclase activity GO:0007190 19 19 1,000 6,957E-03 0,03850243 ! negative regulation of DNA metabolic process GO:0051053 19 19 1,000 6,957E-03 0,03838716 ! positive regulation of T cell proliferation GO:0042102 19 19 1,000 6,957E-03 0,03827257 ! regulation of striated muscle tissue development GO:0016202 20 19 1,000 6,957E-03 0,03815866 ! multicellular organismal metabolic process GO:0044236 19 19 1,000 6,957E-03 0,03804543 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 6,957E-03 0,03793287 ! metanephros development GO:0001656 19 19 1,000 6,957E-03 0,03782098 ! cellular response to oxidative stress GO:0034599 19 19 1,000 6,957E-03 0,03770974 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 1,000 6,957E-03 0,03759915 ! positive regulation of T cell differentiation GO:0045582 19 19 1,000 6,957E-03 0,03748921 ! peripheral nervous system development GO:0007422 19 19 1,000 6,957E-03 0,03737991 ! regulation of protein stability GO:0031647 19 19 1,000 6,957E-03 0,03727125 ! dorsal/ventral pattern formation GO:0009953 19 19 1,000 6,957E-03 0,03716322 ! response to heat GO:0009408 19 19 1,000 6,957E-03 0,03705581 ! regulation of cell development GO:0060284 60 59 2,000 7,001E-03 0,03718585 ! immune effector process GO:0002252 59 59 2,000 7,001E-03 0,037079 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 2,000 7,336E-03 0,03873834 ! regulation of muscle development GO:0048634 21 20 1,000 7,697E-03 0,04053026 ! establishment or maintenance of cell polarity GO:0007163 21 20 1,000 7,697E-03 0,04041479 ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 1,000 7,697E-03 0,04029998 ! neural tube development GO:0021915 21 20 1,000 7,697E-03 0,04018581 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 7,697E-03 0,04007229 ! female gamete generation GO:0007292 20 20 1,000 7,697E-03 0,03995941 ! negative regulation of neuron apoptosis GO:0043524 21 20 1,000 7,697E-03 0,03984717 ! regulation of B cell activation GO:0050864 20 20 1,000 7,697E-03 0,03973555 ! regulation of lymphocyte activation GO:0051249 62 62 2,000 8,032E-03 0,04135156 ! mitotic sister chromatid segregation GO:0000070 21 21 1,000 8,471E-03 0,04348876 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 1,000 8,471E-03 0,04336796 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 1,000 8,471E-03 0,04324783 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! mammary gland development GO:0030879 23 21 1,000 8,471E-03 0,04312836 ! Notch signaling pathway GO:0007219 22 21 1,000 8,471E-03 0,04300955 ! DNA integrity checkpoint GO:0031570 21 21 1,000 8,471E-03 0,04289139 ! regulation of leukocyte mediated immunity GO:0002703 21 21 1,000 8,471E-03 0,04277388 ! regulation of action potential in neuron GO:0019228 21 21 1,000 8,471E-03 0,04265701 ! regulation of multicellular organism growth GO:0040014 21 21 1,000 8,471E-03 0,04254078 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 1,000 8,471E-03 0,04242518 ! negative regulation of protein transport GO:0051224 21 21 1,000 8,471E-03 0,0423102 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 9,279E-03 0,04621911 GO:0090047|positive regulation of transcription regulator activity, ! sister chromatid segregation GO:0000819 22 22 1,000 9,279E-03 0,04609453 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 1,000 9,279E-03 0,04597062 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! ovulation cycle process GO:0022602 22 22 1,000 9,279E-03 0,04584738 ! spindle organization GO:0007051 22 22 1,000 9,279E-03 0,04572479 ! cell chemotaxis GO:0060326 23 22 1,000 9,279E-03 0,04560286 GO:0030595|leukocyte chemotaxis, ! male sex differentiation GO:0046661 22 22 1,000 9,279E-03 0,04548157 ! biopolymer methylation GO:0043414 22 22 1,000 9,279E-03 0,04536093 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 1,000 9,279E-03 0,04524093 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 1,000 9,279E-03 0,04512156 ! cytokinesis GO:0000910 23 22 1,000 9,279E-03 0,04500282 ! negative regulation of protein metabolic process GO:0051248 66 66 2,000 9,54E-03 0,04614811 ! striated muscle tissue development GO:0014706 69 67 2,000 9,941E-03 0,0479619 ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,01011967 0,04869598 ! response to estrogen stimulus GO:0043627 23 23 1,000 0,01011967 0,04856916 ! female gonad development GO:0008585 23 23 1,000 0,01011967 0,04844301 ! regulation of cell size GO:0008361 68 68 2,000 0,01035182 0,0494259 ! regionalization GO:0003002 70 69 2,000 0,01077231 0,05130067 ! regulation of leukocyte activation GO:0002694 69 69 2,000 0,01077231 0,05116845 ! mitochondrial transport GO:0006839 24 24 1,000 0,01099299 0,05208247 ! regulation of action potential GO:0001508 24 24 1,000 0,01099299 0,05194893 ! cellular amino acid biosynthetic process GO:0008652 24 24 1,000 0,01099299 0,05181607 ! glucose homeostasis GO:0042593 24 24 1,000 0,01099299 0,05168388 GO:0033500|carbohydrate homeostasis, ! ovulation cycle GO:0042698 24 24 1,000 0,01099299 0,05155237 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 0,01099299 0,05142153 ! glucan metabolic process GO:0044042 25 24 1,000 0,01099299 0,05129135 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! growth GO:0040007 70 70 2,000 0,01120261 0,05213742 ! muscle tissue development GO:0060537 72 70 2,000 0,01120261 0,05200609 ! regulation of cell activation GO:0050865 71 71 2,000 0,01164278 0,05391368 ! development of primary female sexual characteristics GO:0046545 25 25 1,000 0,01189843 0,05495941 GO:0046660|female sex differentiation, ! positive regulation of DNA binding GO:0043388 26 25 1,000 0,01189843 0,05482202 ! heart morphogenesis GO:0003007 25 25 1,000 0,01189843 0,0546853 ! sensory organ development GO:0007423 72 72 2,000 0,01209285 0,05544059 ! positive regulation of binding GO:0051099 27 26 1,000 0,01283554 0,05869951 ! germ cell development GO:0007281 27 26 1,000 0,01283554 0,05855422 ! pigment metabolic process GO:0042440 26 26 1,000 0,01283554 0,05840964 ! synapse organization GO:0050808 26 26 1,000 0,01283554 0,05826577 ! response to oxidative stress GO:0006979 76 75 2,000 0,01350279 0,06114409 ! energy reserve metabolic process GO:0006112 28 27 1,000 0,01380388 0,0623543 ! mesenchymal cell development GO:0014031 29 27 1,000 0,01380388 0,06220184 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! inner ear development GO:0048839 27 27 1,000 0,01380388 0,06205013 ! cell growth GO:0016049 27 27 1,000 0,01380388 0,06189916 ! carbohydrate transport GO:0008643 28 28 1,000 0,01480301 0,06621831 ! developmental growth GO:0048589 28 28 1,000 0,01480301 0,06605798 ! microtubule-based movement GO:0007018 82 78 2,000 0,01500303 0,06678885 ! positive regulation of cell cycle GO:0045787 29 29 1,000 0,01583249 0,0703115 ! viral reproductive process GO:0022415 29 29 1,000 0,01583249 0,07014248 ! leukocyte migration GO:0050900 30 29 1,000 0,01583249 0,06997428 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,01583249 0,06980687 ! regulation of epithelial cell proliferation GO:0050678 29 29 1,000 0,01583249 0,06964027 ! positive regulation of protein transport GO:0051222 29 29 1,000 0,01583249 0,06947446 ! response to UV GO:0009411 29 29 1,000 0,01583249 0,06930944 ! MAPKKK cascade GO:0000165 82 81 2,000 0,0165943 0,07247224 ! regulation of ossification GO:0030278 30 30 1,000 0,01689188 0,0735975 ! vesicle organization GO:0016050 30 30 1,000 0,01689188 0,07342392 ! establishment of organelle localization GO:0051656 31 30 1,000 0,01689188 0,07325116 ! skeletal muscle fiber development GO:0048741 31 31 1,000 0,01798077 0,07779006 ! B cell activation GO:0042113 31 31 1,000 0,01798077 0,07760788 ! aging GO:0007568 32 31 1,000 0,01798077 0,07742656 ! regulation of cellular localization GO:0060341 86 85 2,000 0,01885857 0,08101711 ! positive regulation of cell differentiation GO:0045597 87 85 2,000 0,01885857 0,0808287 ! negative regulation of cell growth GO:0030308 32 32 1,000 0,01909873 0,08166812 ! muscle fiber development GO:0048747 32 32 1,000 0,01909873 0,08147908 ! cell maturation GO:0048469 32 32 1,000 0,01909873 0,0812909 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 1,000 0,01909873 0,0811036 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,01909873 0,08091715 ! kidney development GO:0001822 32 32 1,000 0,01909873 0,08073156 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 2,000 0,01945021 0,08202913 ! negative regulation of cell size GO:0045792 33 33 1,000 0,02024534 0,08518757 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 0,02024534 0,08499352 ! regulation of angiogenesis GO:0045765 35 34 1,000 0,02142017 0,08972132 ! regulation of bone remodeling GO:0046850 34 34 1,000 0,02142017 0,08951787 ! cellular polysaccharide metabolic process GO:0044264 35 34 1,000 0,02142017 0,08931534 ! regulation of protein catabolic process GO:0042176 35 34 1,000 0,02142017 0,08911372 ! secondary metabolic process GO:0019748 34 34 1,000 0,02142017 0,08891302 ! negative regulation of response to stimulus GO:0048585 34 34 1,000 0,02142017 0,08871321 ! viral reproduction GO:0016032 34 34 1,000 0,02142017 0,0885143 ! multicellular organism reproduction GO:0032504 36 35 1,000 0,02262283 0,0932749 GO:0048609|reproductive process in a multicellular organism, ! regulation of tissue remodeling GO:0034103 35 35 1,000 0,02262283 0,0930667 ! response to steroid hormone stimulus GO:0048545 35 35 1,000 0,02262283 0,09285942 ! regulation of immune effector process GO:0002697 35 35 1,000 0,02262283 0,09265307 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 1,000 0,02385291 0,0974743 ! embryonic limb morphogenesis GO:0030326 36 36 1,000 0,02385291 0,09725864 GO:0035113|embryonic appendage morphogenesis, ! female pregnancy GO:0007565 37 36 1,000 0,02385291 0,09704395 ! positive regulation of organelle organization GO:0010638 36 36 1,000 0,02385291 0,09683019 ! gonad development GO:0008406 36 36 1,000 0,02385291 0,09661738 ! activation of immune response GO:0002253 36 36 1,000 0,02385291 0,0964055 ! coagulation GO:0050817 39 36 1,000 0,02385291 0,09619455 GO:0007596|blood coagulation, ! pattern specification process GO:0007389 96 94 2,000 0,02455302 0,09880178 ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 0,02510999 0,10082291 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! regulation of transcription factor activity GO:0051090 38 37 1,000 0,02510999 0,10060373 GO:0090046|regulation of transcription regulator activity, ! meiosis GO:0007126 37 37 1,000 0,02510999 0,1003855 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of protein kinase activity GO:0006469 37 37 1,000 0,02510999 0,10016821 ! negative regulation of growth GO:0045926 37 37 1,000 0,02510999 0,09995187 ! regulation of cell growth GO:0001558 97 96 2,000 0,02593156 0,1029997 ! negative regulation of kinase activity GO:0033673 38 38 1,000 0,02639369 0,10460982 ! chromosome segregation GO:0007059 38 38 1,000 0,02639369 0,10438533 ! meiotic cell cycle GO:0051321 38 38 1,000 0,02639369 0,10416181 ! axon guidance GO:0007411 39 38 1,000 0,02639369 0,10393924 ! posttranscriptional regulation of gene expression GO:0010608 98 98 2,000 0,02735121 0,10748035 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 0,0277036 0,10863348 ! hemostasis GO:0007599 42 39 1,000 0,0277036 0,10840283 ! regulation of MAPKKK cascade GO:0043408 41 39 1,000 0,0277036 0,10817317 ! positive regulation of T cell activation GO:0050870 39 39 1,000 0,0277036 0,10794447 ! developmental maturation GO:0021700 39 39 1,000 0,0277036 0,10771674 ! limb development GO:0060173 39 39 1,000 0,0277036 0,10748997 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! protein oligomerization GO:0051259 39 39 1,000 0,0277036 0,10726415 ! anti-apoptosis GO:0006916 100 99 2,000 0,02807645 0,10847985 ! muscle organ development GO:0007517 102 100 2,000 0,02881194 0,11108871 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 2,000 0,02881194 0,11085679 ! response to other organism GO:0051707 101 100 2,000 0,02881194 0,11062584 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 0,02903934 0,11126715 ! negative regulation of transferase activity GO:0051348 40 40 1,000 0,02903934 0,1110363 ! organelle localization GO:0051640 41 40 1,000 0,02903934 0,11080641 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 0,03040051 0,11576062 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cell cycle checkpoint GO:0000075 42 41 1,000 0,03040051 0,11552194 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 1,000 0,03040051 0,11528424 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 0,03178674 0,12029354 ! cytosolic calcium ion homeostasis GO:0051480 42 42 1,000 0,03178674 0,12004704 ! development of primary sexual characteristics GO:0045137 42 42 1,000 0,03178674 0,11980155 ! protein ubiquitination GO:0016567 43 42 1,000 0,03178674 0,11955705 ! response to protein stimulus GO:0051789 42 42 1,000 0,03178674 0,11931356 ! forebrain development GO:0030900 43 42 1,000 0,03178674 0,11907105 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 1,000 0,03178674 0,11882952 ! rRNA transcription GO:0009303 5 5 0,000 0,03299564 0,12309913 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,03299564 0,12285045 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,03299564 0,12260277 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,03299564 0,12235608 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,03299564 0,12211039 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,03299564 0,12186568 ! reproductive cellular process GO:0048610 5 5 0,000 0,03299564 0,12162194 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,03299564 0,12137919 ! water transport GO:0006833 5 5 0,000 0,03299564 0,12113739 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,03299564 0,12089656 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,03299564 0,12065669 ! glycerol metabolic process GO:0006071 5 5 0,000 0,03299564 0,12041777 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,03299564 0,12017979 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,03299564 0,11994275 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,03299564 0,11970664 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,03299564 0,11947146 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,03299564 0,1192372 ! filopodium assembly GO:0046847 7 5 0,000 0,03299564 0,11900386 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,03299564 0,11877143 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,03299564 0,11853991 ! GTP metabolic process GO:0046039 5 5 0,000 0,03299564 0,11830928 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,03299564 0,11807956 ! mRNA stabilization GO:0048255 5 5 0,000 0,03299564 0,11785072 GO:0043489|RNA stabilization, ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,03299564 0,11762277 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,03299564 0,1173957 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,03299564 0,1171695 ! social behavior GO:0035176 5 5 0,000 0,03299564 0,11694418 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,03299564 0,11671972 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,03299564 0,11649612 ! dopamine receptor signaling pathway GO:0007212 5 5 0,000 0,03299564 0,11627337 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,03299564 0,11605147 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,03299564 0,11583042 ! response to lipid GO:0033993 5 5 0,000 0,03299564 0,11561021 ! erythrocyte maturation GO:0043249 5 5 0,000 0,03299564 0,11539084 ! hippocampus development GO:0021766 6 5 0,000 0,03299564 0,1151723 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,03299564 0,11495458 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,03299564 0,11473768 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,03299564 0,1145216 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,03299564 0,11430634 ! mechanosensory behavior GO:0007638 5 5 0,000 0,03299564 0,11409188 ! heart looping GO:0001947 5 5 0,000 0,03299564 0,11387823 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,03299564 0,11366537 ! response to interferon-gamma GO:0034341 5 5 0,000 0,03299564 0,11345331 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,03299564 0,11324203 ! pH reduction GO:0045851 5 5 0,000 0,03299564 0,11303155 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,03299564 0,11282184 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,03299564 0,11261291 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,03299564 0,11240475 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,03299564 0,11219737 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,03299564 0,11199074 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,03299564 0,11178488 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,03299564 0,11157977 ! adrenal gland development GO:0030325 5 5 0,000 0,03299564 0,11137541 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,03299564 0,1111718 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,03299564 0,11096893 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,03299564 0,1107668 ! astrocyte differentiation GO:0048708 5 5 0,000 0,03299564 0,1105654 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,03299564 0,11036474 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,03299564 0,1101648 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,03299564 0,10996559 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,03299564 0,1097671 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,03299564 0,10956932 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,03299564 0,10937225 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,03299564 0,10917589 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,03299564 0,10898024 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,03299564 0,10878528 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,03299564 0,10859102 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,03299564 0,10839745 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,03299564 0,10820458 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,03299564 0,10801238 ! response to ATP GO:0033198 5 5 0,000 0,03299564 0,10782087 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,03299564 0,10763004 ! regulation of appetite GO:0032098 5 5 0,000 0,03299564 0,10743988 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,03299564 0,10725039 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,03299564 0,10706157 ! regulation of phospholipase A2 activity GO:0032429 5 5 0,000 0,03299564 0,10687341 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,03299564 0,10668592 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,03299564 0,10649908 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03299564 0,10631289 ! receptor clustering GO:0043113 5 5 0,000 0,03299564 0,10612735 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,03299564 0,10594246 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,03299564 0,10575821 ! retinol metabolic process GO:0042572 5 5 0,000 0,03299564 0,1055746 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,03299564 0,10539163 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,03299564 0,10520929 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,03299564 0,10502759 ! parturition GO:0007567 5 5 0,000 0,03299564 0,1048465 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03299564 0,10466605 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 0,03299564 0,10448621 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,03299564 0,10430698 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,03299564 0,10412838 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,03299564 0,10395038 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,03299564 0,10377299 ! oligodendrocyte development GO:0014003 5 5 0,000 0,03299564 0,1035962 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,03299564 0,10342002 ! activated T cell proliferation GO:0050798 5 5 0,000 0,03299564 0,10324443 ! interaction with symbiont GO:0051702 5 5 0,000 0,03299564 0,10306944 ! cellular extravasation GO:0045123 5 5 0,000 0,03299564 0,10289505 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,03299564 0,10272124 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,03299564 0,10254801 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,03299564 0,10237537 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,03299564 0,10220331 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,03299564 0,10203183 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,03299564 0,10186092 ! response to amine stimulus GO:0014075 5 5 0,000 0,03299564 0,10169059 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,03299564 0,10152082 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,03299564 0,10135162 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,03299564 0,10118298 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,03299564 0,1010149 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,03299564 0,10084738 ! neuron recognition GO:0008038 5 5 0,000 0,03299564 0,10068042 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,03299564 0,100514 ! decidualization GO:0046697 5 5 0,000 0,03299564 0,10034814 ! hair follicle maturation GO:0048820 5 5 0,000 0,03299564 0,10018282 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,03299564 0,10001805 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,03299564 0,09985381 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,03299564 0,09969012 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,03299564 0,09952696 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,03299564 0,09936433 ! postreplication repair GO:0006301 5 5 0,000 0,03299564 0,09920224 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,03299564 0,09904067 GO:0021517|ventral spinal cord development, ! histone methylation GO:0016571 5 5 0,000 0,03299564 0,09887963 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03299564 0,09871911 ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,03299564 0,09855911 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,03299564 0,09839963 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,03299564 0,09824067 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,03299564 0,09808221 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,03299564 0,09792427 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,03299564 0,09776684 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,03299564 0,09760991 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,03299564 0,09745348 ! sterol catabolic process GO:0016127 5 5 0,000 0,03299564 0,09729756 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,03299564 0,09714213 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,03299564 0,0969872 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,03299564 0,09683276 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! zymogen activation GO:0031638 5 5 0,000 0,03299564 0,09667881 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,03299564 0,09652535 ! cellular response to nutrient GO:0031670 5 5 0,000 0,03299564 0,09637238 ! negative regulation of neuroblast proliferation GO:0007406 5 5 0,000 0,03299564 0,09621989 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,03299564 0,09606789 ! nucleosome positioning GO:0016584 5 5 0,000 0,03299564 0,09591636 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,03299564 0,09576531 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,03299564 0,09561474 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,03299564 0,09546463 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,03299564 0,095315 ! NADPH regeneration GO:0006740 5 5 0,000 0,03299564 0,09516584 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,03299564 0,09501714 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,03299564 0,09486891 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,03299564 0,09472114 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,03299564 0,09457383 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,03299564 0,09442698 ! sarcomere organization GO:0045214 5 5 0,000 0,03299564 0,09428058 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,03299564 0,09413463 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,03299564 0,09398914 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,03299564 0,09384409 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,03299564 0,09369949 GO:0045622|regulation of T-helper cell differentiation, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,03299564 0,09355534 ! male genitalia development GO:0030539 5 5 0,000 0,03299564 0,09341163 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,03299564 0,09326836 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,03299564 0,09312553 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,03299564 0,09298314 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,03299564 0,09284118 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,03299564 0,09269965 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,03299564 0,09255856 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,03299564 0,09241789 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,03299564 0,09227765 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,03299564 0,09213784 ! ATP catabolic process GO:0006200 5 5 0,000 0,03299564 0,09199845 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03299564 0,09185947 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,03299564 0,09172092 ! blastocyst formation GO:0001825 5 5 0,000 0,03299564 0,09158279 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,03299564 0,09144507 ! embryonic gut development GO:0048566 5 5 0,000 0,03299564 0,09130777 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,03299564 0,09117087 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,03299564 0,09103439 ! activation of innate immune response GO:0002218 5 5 0,000 0,03299564 0,09089831 GO:0002758|innate immune response-activating signal transduction, ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 0,000 0,03299564 0,09076265 ! catecholamine transport GO:0051937 5 5 0,000 0,03299564 0,09062738 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,03299564 0,09049252 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,03299564 0,09035806 ! muscle adaptation GO:0043500 5 5 0,000 0,03299564 0,09022399 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,03299564 0,09009033 ! embryonic heart tube development GO:0035050 5 5 0,000 0,03299564 0,08995706 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,03299564 0,08982418 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,03299564 0,0896917 ! defense response to fungus GO:0050832 5 5 0,000 0,03299564 0,08955961 ! lysogeny GO:0030069 5 5 0,000 0,03299564 0,0894279 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,03299564 0,08929658 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,03299564 0,08916565 ! establishment of cell polarity GO:0030010 5 5 0,000 0,03299564 0,0890351 ! mitochondrion localization GO:0051646 5 5 0,000 0,03299564 0,08890493 ! nucleus localization GO:0051647 5 5 0,000 0,03299564 0,08877514 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,03299564 0,08864573 ! mitochondrion organization GO:0007005 44 43 1,000 0,03319764 0,08905858 ! homeostasis of number of cells GO:0048872 44 43 1,000 0,03319764 0,08892913 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 0,03319764 0,08880006 ! humoral immune response GO:0006959 44 44 1,000 0,03463283 0,0925048 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 1,000 0,03463283 0,09237093 ! negative regulation of organelle organization GO:0010639 45 44 1,000 0,03463283 0,09223744 ! positive regulation of lymphocyte activation GO:0051251 44 44 1,000 0,03463283 0,09210434 ! amine biosynthetic process GO:0009309 46 45 1,000 0,03609195 0,0958465 ! regulation of DNA binding GO:0051101 47 45 1,000 0,03609195 0,09570859 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 1,000 0,03609195 0,09557108 ! Wnt receptor signaling pathway GO:0016055 46 45 1,000 0,03609195 0,09543396 ! tube morphogenesis GO:0035239 47 46 1,000 0,03757463 0,09921209 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 1,000 0,03757463 0,09907016 ! positive regulation of ligase activity GO:0051351 47 46 1,000 0,03757463 0,09892863 ! rhythmic process GO:0048511 47 47 1,000 0,0390805 0,10274658 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,03946578 0,10361173 ! axon extension GO:0048675 7 6 0,000 0,03946578 0,10346435 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,03946578 0,10331738 ! tRNA modification GO:0006400 6 6 0,000 0,03946578 0,10317083 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,03946578 0,1030247 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,03946578 0,10287898 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,03946578 0,10273367 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,03946578 0,10258877 ! myotube differentiation GO:0014902 6 6 0,000 0,03946578 0,10244428 ! bone remodeling GO:0046849 6 6 0,000 0,03946578 0,10230019 ! N-glycan processing GO:0006491 6 6 0,000 0,03946578 0,10215651 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,03946578 0,10201324 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,03946578 0,10187036 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,03946578 0,10172788 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,03946578 0,10158581 ! RNA methylation GO:0001510 6 6 0,000 0,03946578 0,10144412 ! cartilage condensation GO:0001502 7 6 0,000 0,03946578 0,10130284 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,03946578 0,10116194 ! regulation of positive chemotaxis GO:0050926 6 6 0,000 0,03946578 0,10102144 GO:0050927|positive regulation of positive chemotaxis, ! succinate metabolic process GO:0006105 7 6 0,000 0,03946578 0,10088133 ! artery development GO:0060840 6 6 0,000 0,03946578 0,1007416 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,03946578 0,10060226 ! bile acid metabolic process GO:0008206 6 6 0,000 0,03946578 0,10046331 ! androgen metabolic process GO:0008209 6 6 0,000 0,03946578 0,10032474 ! estrogen metabolic process GO:0008210 6 6 0,000 0,03946578 0,10018655 ! limbic system development GO:0021761 7 6 0,000 0,03946578 0,10004874 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,03946578 0,09991131 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 0,000 0,03946578 0,09977426 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,03946578 0,09963758 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,03946578 0,09950128 ! pathogenesis GO:0009405 6 6 0,000 0,03946578 0,09936535 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,03946578 0,09922979 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,03946578 0,0990946 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,03946578 0,09895978 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,03946578 0,09882532 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,03946578 0,09869123 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,03946578 0,0985575 ! arginine metabolic process GO:0006525 6 6 0,000 0,03946578 0,09842414 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,03946578 0,09829113 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,03946578 0,09815848 ! glutamate catabolic process GO:0006538 7 6 0,000 0,03946578 0,0980262 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,03946578 0,09789426 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,03946578 0,09776268 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,03946578 0,09763146 GO:0005978|glycogen biosynthetic process, ! V(D)J recombination GO:0033151 6 6 0,000 0,03946578 0,09750059 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,03946578 0,09737006 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,03946578 0,09723989 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,03946578 0,09711006 ! regulation of heart rate GO:0002027 6 6 0,000 0,03946578 0,09698058 ! lipid digestion GO:0044241 6 6 0,000 0,03946578 0,09685145 ! asymmetric protein localization GO:0008105 6 6 0,000 0,03946578 0,09672266 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,03946578 0,09659421 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,03946578 0,0964661 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,03946578 0,09633833 ! regulation of vascular permeability GO:0043114 6 6 0,000 0,03946578 0,0962109 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,03946578 0,0960838 ! ruffle organization GO:0031529 6 6 0,000 0,03946578 0,09595704 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,03946578 0,09583062 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,03946578 0,09570452 ! neutral amino acid transport GO:0015804 6 6 0,000 0,03946578 0,09557876 ! L-amino acid transport GO:0015807 6 6 0,000 0,03946578 0,09545333 ! bone mineralization GO:0030282 6 6 0,000 0,03946578 0,09532823 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,03946578 0,09520345 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,03946578 0,095079 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of bone resorption GO:0045124 6 6 0,000 0,03946578 0,09495488 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,03946578 0,09483108 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,03946578 0,0947076 ! G1 DNA damage checkpoint GO:0031571 6 6 0,000 0,03946578 0,09458444 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,03946578 0,09446161 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,03946578 0,09433909 ! regulation of organ growth GO:0046620 6 6 0,000 0,03946578 0,09421689 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,03946578 0,094095 ! response to dsRNA GO:0043331 6 6 0,000 0,03946578 0,09397343 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,03946578 0,09385218 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,03946578 0,09373123 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,03946578 0,0936106 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,03946578 0,09349028 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,03946578 0,09337027 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,03946578 0,09325056 ! multicellular organismal aging GO:0010259 6 6 0,000 0,03946578 0,09313116 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,03946578 0,09301207 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,03946578 0,09289328 ! erythrocyte development GO:0048821 6 6 0,000 0,03946578 0,09277479 ! renal water homeostasis GO:0003091 6 6 0,000 0,03946578 0,09265661 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,03946578 0,09253872 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,03946578 0,09242114 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,03946578 0,09230385 ! ribosome assembly GO:0042255 6 6 0,000 0,03946578 0,09218687 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,03946578 0,09207017 ! fucose catabolic process GO:0019317 6 6 0,000 0,03946578 0,09195378 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,03946578 0,09183767 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,03946578 0,09172186 ! regulation of lipid transport GO:0032368 6 6 0,000 0,03946578 0,09160634 ! regulation of cell division GO:0051302 6 6 0,000 0,03946578 0,09149112 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,03946578 0,09137618 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,03946578 0,09126153 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,03946578 0,09114716 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,03946578 0,09103309 ! neuroblast proliferation GO:0007405 6 6 0,000 0,03946578 0,0909193 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,03946578 0,09080579 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,03946578 0,09069256 ! regulation of glucose transport GO:0010827 6 6 0,000 0,03946578 0,09057962 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,03946578 0,09046696 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,03946578 0,09035458 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,03946578 0,09024248 ! lymph node development GO:0048535 6 6 0,000 0,03946578 0,09013065 ! organic cation transport GO:0015695 6 6 0,000 0,03946578 0,09001911 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,03946578 0,08990783 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,03946578 0,08979684 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,03946578 0,08968611 ! sperm-egg recognition GO:0035036 7 6 0,000 0,03946578 0,08957566 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,03946578 0,08946548 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,03946578 0,08935557 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,03946578 0,08924593 ! alditol metabolic process GO:0019400 6 6 0,000 0,03946578 0,08913656 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,03946578 0,08902746 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,03946578 0,08891863 ! maternal placenta development GO:0001893 6 6 0,000 0,03946578 0,08881006 ! localization within membrane GO:0051668 6 6 0,000 0,03946578 0,08870175 ! calcium ion transport GO:0006816 48 48 1,000 0,04060919 0,09116046 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 1,000 0,04060919 0,09104956 ! divalent metal ion transport GO:0070838 49 49 1,000 0,04216036 0,09441256 ! response to nutrient GO:0007584 49 49 1,000 0,04216036 0,09429798 ! regulation of ligase activity GO:0051340 50 49 1,000 0,04216036 0,09418368 ! positive regulation of cell activation GO:0050867 49 49 1,000 0,04216036 0,09406965 GO:0002696|positive regulation of leukocyte activation, ! negative regulation of transport GO:0051051 51 50 1,000 0,04373364 0,09746202 ! protein modification by small protein conjugation GO:0032446 52 51 1,000 0,04532868 0,10089464 ! positive regulation of immune response GO:0050778 51 51 1,000 0,04532868 0,10077294 ! respiratory burst GO:0045730 7 7 0,000 0,04589356 0,10190583 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,04589356 0,1017832 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,04589356 0,10166086 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,04589356 0,10153882 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,04589356 0,10141707 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,04589356 0,10129562 ! regulation of chemokine production GO:0032642 7 7 0,000 0,04589356 0,10117445 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,04589356 0,10105357 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,04589356 0,10093298 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,04589356 0,10081268 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,04589356 0,10069267 GO:0043241|protein complex disassembly, ! gene silencing by RNA GO:0031047 7 7 0,000 0,04589356 0,10057294 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,04589356 0,10045349 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,04589356 0,10033433 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,04589356 0,10021545 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,04589356 0,10009685 ! axis specification GO:0009798 7 7 0,000 0,04589356 0,09997853 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,04589356 0,0998605 ! visual behavior GO:0007632 7 7 0,000 0,04589356 0,09974274 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,04589356 0,09962525 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,04589356 0,09950805 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,04589356 0,09939112 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,04589356 0,09927446 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,04589356 0,09915808 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,04589356 0,09904197 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,04589356 0,09892613 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,04589356 0,09881056 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,04589356 0,09869526 ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,04589356 0,09858023 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,04589356 0,09846547 ! protein targeting to ER GO:0045047 8 7 0,000 0,04589356 0,09835098 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,04589356 0,09823675 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,04589356 0,09812278 ! endoderm development GO:0007492 7 7 0,000 0,04589356 0,09800908 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,04589356 0,09789565 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,04589356 0,09778247 GO:0006688|glycosphingolipid biosynthetic process, ! response to hexose stimulus GO:0009746 7 7 0,000 0,04589356 0,09766956 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,04589356 0,09755691 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,04589356 0,09744452 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,04589356 0,09733238 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,04589356 0,0972205 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,04589356 0,09710889 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,04589356 0,09699752 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,04589356 0,09688641 ! response to X-ray GO:0010165 7 7 0,000 0,04589356 0,09677556 ! regulation of intracellular pH GO:0051453 7 7 0,000 0,04589356 0,09666496 ! UV protection GO:0009650 7 7 0,000 0,04589356 0,09655461 ! DNA integration GO:0015074 7 7 0,000 0,04589356 0,09644451 ! myofibril assembly GO:0030239 7 7 0,000 0,04589356 0,09633467 GO:0055002|striated muscle cell development, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,04589356 0,09622507 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,04589356 0,09611573 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,04589356 0,09600663 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,04589356 0,09589778 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,04589356 0,09578917 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,04589356 0,09568081 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,04589356 0,0955727 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,04589356 0,09546483 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,04589356 0,0953572 ! eating behavior GO:0042755 7 7 0,000 0,04589356 0,09524982 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,04589356 0,09514268 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,04589356 0,09503577 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,04589356 0,09492911 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,04589356 0,09482269 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,04589356 0,09471651 ! cranial nerve development GO:0021545 7 7 0,000 0,04589356 0,09461056 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,04589356 0,09450485 ! induction of an organ GO:0001759 7 7 0,000 0,04589356 0,09439937 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,04589356 0,09429414 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,04589356 0,09418913 ! autonomic nervous system development GO:0048483 7 7 0,000 0,04589356 0,09408436 ! intracellular lipid transport GO:0032365 7 7 0,000 0,04589356 0,09397982 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,04589356 0,09387552 ! platelet activation GO:0030168 8 7 0,000 0,04589356 0,09377144 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,04589356 0,0936676 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,04589356 0,09356398 ! natural killer cell activation GO:0030101 7 7 0,000 0,04589356 0,0934606 ! NADP metabolic process GO:0006739 7 7 0,000 0,04589356 0,09335744 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,04589356 0,09325451 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,04589356 0,09315181 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,04589356 0,09304933 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,04589356 0,09294708 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,04589356 0,09284505 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,04589356 0,09274324 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,04589356 0,09264166 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,04589356 0,09254031 ! cell-cell recognition GO:0009988 8 7 0,000 0,04589356 0,09243917 ! hormone catabolic process GO:0042447 7 7 0,000 0,04589356 0,09233825 ! dopamine metabolic process GO:0042417 7 7 0,000 0,04589356 0,09223756 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,04589356 0,09213708 ! oxygen transport GO:0015671 7 7 0,000 0,04589356 0,09203682 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,04589356 0,09193678 ! regulation of mRNA stability GO:0043488 7 7 0,000 0,04589356 0,09183696 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,04589356 0,09173735 ! regulation of axon extension GO:0030516 7 7 0,000 0,04589356 0,09163796 ! cell killing GO:0001906 7 7 0,000 0,04589356 0,09153879 ! adult feeding behavior GO:0008343 7 7 0,000 0,04589356 0,09143983 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,04589356 0,09134108 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,04589356 0,09124255 ! regulation of body fluid levels GO:0050878 55 52 1,000 0,04694515 0,09323266 ! response to light stimulus GO:0009416 53 52 1,000 0,04694515 0,09313231 ! sodium ion transport GO:0006814 53 53 1,000 0,04858269 0,09627731 ! negative regulation of multicellular organismal process GO:0051241 55 54 1,000 0,05024097 0,0994566 ! protein modification by small protein conjugation or removal GO:0070647 56 55 1,000 0,05191964 0,10266941 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,05227926 0,10326975 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,05227926 0,10315919 ! positive regulation of translation GO:0045727 8 8 0,000 0,05227926 0,10304885 ! superoxide anion generation GO:0042554 8 8 0,000 0,05227926 0,10293876 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,05227926 0,1028289 ! cGMP metabolic process GO:0046068 8 8 0,000 0,05227926 0,10271927 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,05227926 0,10260988 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,05227926 0,10250072 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,05227926 0,10239179 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,05227926 0,1022831 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,05227926 0,10217463 ! zinc ion transport GO:0006829 8 8 0,000 0,05227926 0,1020664 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,05227926 0,10195839 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,05227926 0,10185061 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,05227926 0,10174306 ! lipid localization GO:0010876 8 8 0,000 0,05227926 0,10163574 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,05227926 0,10152864 ! response to cAMP GO:0051591 8 8 0,000 0,05227926 0,10142177 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,05227926 0,10131512 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,05227926 0,1012087 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,05227926 0,1011025 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,05227926 0,10099652 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,05227926 0,10089076 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,05227926 0,10078523 ! sensory perception of taste GO:0050909 8 8 0,000 0,05227926 0,10067992 ! organelle fusion GO:0048284 8 8 0,000 0,05227926 0,10057482 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,05227926 0,10046995 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,05227926 0,10036529 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,05227926 0,10026085 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,05227926 0,10015663 ! sperm motility GO:0030317 8 8 0,000 0,05227926 0,10005263 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,05227926 0,09994884 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,05227926 0,09984526 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,05227926 0,0997419 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,05227926 0,09963876 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,05227926 0,09953583 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,05227926 0,09943311 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,05227926 0,0993306 ! Golgi organization GO:0007030 8 8 0,000 0,05227926 0,0992283 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,05227926 0,09912621 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,05227926 0,09902434 ! positive regulation of endothelial cell migration GO:0010595 8 8 0,000 0,05227926 0,09892267 ! fructose metabolic process GO:0006000 8 8 0,000 0,05227926 0,09882121 ! mannose metabolic process GO:0006013 9 8 0,000 0,05227926 0,09871996 ! NAD metabolic process GO:0019674 8 8 0,000 0,05227926 0,09861891 ! plasma membrane fusion GO:0045026 8 8 0,000 0,05227926 0,09851808 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 0,000 0,05227926 0,09841745 ! response to fungus GO:0009620 8 8 0,000 0,05227926 0,09831702 ! stem cell differentiation GO:0048863 8 8 0,000 0,05227926 0,0982168 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,05227926 0,09811678 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,05227926 0,09801697 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,05227926 0,09791736 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,05227926 0,09781795 ! regulation of vasodilation GO:0042312 8 8 0,000 0,05227926 0,09771874 ! vasoconstriction GO:0042310 8 8 0,000 0,05227926 0,09761974 ! muscle cell development GO:0055001 8 8 0,000 0,05227926 0,09752093 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,05227926 0,09742232 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,05227926 0,09732392 ! sensory perception of pain GO:0019233 8 8 0,000 0,05227926 0,09722571 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,05227926 0,0971277 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,05227926 0,09702989 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,05227926 0,09693227 ! chromatin silencing GO:0006342 8 8 0,000 0,05227926 0,09683485 ! tissue regeneration GO:0042246 8 8 0,000 0,05227926 0,09673763 ! salivary gland development GO:0007431 8 8 0,000 0,05227926 0,0966406 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,05227926 0,09654377 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,05227926 0,09644713 ! water homeostasis GO:0030104 8 8 0,000 0,05227926 0,09635068 ! cofactor transport GO:0051181 8 8 0,000 0,05227926 0,09625442 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,05227926 0,09615836 ! acid secretion GO:0046717 8 8 0,000 0,05227926 0,09606249 ! positive regulation of leukocyte migration GO:0002687 8 8 0,000 0,05227926 0,09596681 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,05227926 0,09587132 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,05227926 0,09577602 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,05227926 0,09568091 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,05227926 0,09558599 ! regulation of RNA stability GO:0043487 8 8 0,000 0,05227926 0,09549126 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,05227926 0,09539671 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,05227926 0,09530235 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,05227926 0,09520818 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,05227926 0,09511419 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,05227926 0,09502039 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,05227926 0,09492678 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,05227926 0,09483335 ! developmental induction GO:0031128 8 8 0,000 0,05227926 0,0947401 GO:0045168|cell-cell signaling involved in cell fate specification, ! peptide hormone secretion GO:0030072 8 8 0,000 0,05227926 0,09464703 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,05227926 0,09455415 ! actin filament polymerization GO:0030041 9 8 0,000 0,05227926 0,09446145 ! cytoplasmic sequestering of protein GO:0051220 8 8 0,000 0,05227926 0,09436893 ! peptide hormone processing GO:0016486 8 8 0,000 0,05227926 0,09427659 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,05227926 0,09418444 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,05227926 0,09409246 ! extracellular structure organization GO:0043062 56 56 1,000 0,05361837 0,09640845 ! lactation GO:0007595 10 9 0,000 0,05862314 0,10530453 ! embryonic pattern specification GO:0009880 10 9 0,000 0,05862314 0,105202 ! positive regulation of cell size GO:0045793 9 9 0,000 0,05862314 0,10509966 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,05862314 0,10499752 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,05862314 0,10489559 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,05862314 0,10479384 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,05862314 0,1046923 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 0,000 0,05862314 0,10459095 ! viral genome replication GO:0019079 9 9 0,000 0,05862314 0,1044898 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,05862314 0,10438884 ! copper ion transport GO:0006825 9 9 0,000 0,05862314 0,10428808 ! lipid phosphorylation GO:0046834 9 9 0,000 0,05862314 0,10418751 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,05862314 0,10408714 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,05862314 0,10398696 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,05862314 0,10388697 ! RNA polyadenylation GO:0043631 9 9 0,000 0,05862314 0,10378718 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,05862314 0,10368757 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,05862314 0,10358816 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,05862314 0,10348894 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,05862314 0,10338991 ! phospholipid efflux GO:0033700 9 9 0,000 0,05862314 0,10329106 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,05862314 0,10319241 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,05862314 0,10309394 GO:0042107|cytokine metabolic process, ! positive regulation of endothelial cell proliferation GO:0001938 9 9 0,000 0,05862314 0,10299567 ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,05862314 0,10289757 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,05862314 0,10279967 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 0,000 0,05862314 0,10270195 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,05862314 0,10260442 ! methionine metabolic process GO:0006555 9 9 0,000 0,05862314 0,10250707 ! glutamine metabolic process GO:0006541 9 9 0,000 0,05862314 0,10240991 ! cerebral cortex development GO:0021987 9 9 0,000 0,05862314 0,10231293 ! response to osmotic stress GO:0006970 9 9 0,000 0,05862314 0,10221613 ! pigmentation during development GO:0048066 9 9 0,000 0,05862314 0,10211952 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,05862314 0,10202309 ! central nervous system neuron development GO:0021954 10 9 0,000 0,05862314 0,10192684 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,05862314 0,10183078 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,05862314 0,10173489 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,05862314 0,10163918 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,05862314 0,10154366 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,05862314 0,10144831 ! L-glutamate transport GO:0015813 9 9 0,000 0,05862314 0,10135315 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,05862314 0,10125816 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,05862314 0,10116335 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,05862314 0,10106871 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,05862314 0,10097425 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,05862314 0,10087997 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,05862314 0,10078587 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,05862314 0,10069194 ! positive regulation of protein import into nucleus GO:0042307 9 9 0,000 0,05862314 0,10059819 ! DNA replication initiation GO:0006270 9 9 0,000 0,05862314 0,10050461 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,05862314 0,1004112 GO:0006692|prostanoid metabolic process, ! regulation of cellular pH GO:0030641 9 9 0,000 0,05862314 0,10031797 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,05862314 0,10022491 ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,05862314 0,10013202 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,05862314 0,10003931 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,05862314 0,09994676 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,05862314 0,09985439 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,05862314 0,09976219 ! regulation of leukocyte migration GO:0002685 9 9 0,000 0,05862314 0,09967016 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,05862314 0,0995783 ! collagen catabolic process GO:0030574 9 9 0,000 0,05862314 0,0994866 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,05862314 0,09939508 ! purine base metabolic process GO:0006144 9 9 0,000 0,05862314 0,09930372 ! gas transport GO:0015669 9 9 0,000 0,05862314 0,09921254 ! cholesterol efflux GO:0033344 9 9 0,000 0,05862314 0,09912152 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,05862314 0,09903066 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,05862314 0,09893998 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,05862314 0,09884945 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 0,000 0,05862314 0,0987591 ! actin filament-based movement GO:0030048 9 9 0,000 0,05862314 0,09866891 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,05862314 0,09857888 ! protein polymerization GO:0051258 65 60 1,000 0,0606074 0,10182265 ! proteasomal protein catabolic process GO:0010498 62 61 1,000 0,06240157 0,10474144 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! regulation of protein amino acid phosphorylation GO:0001932 62 61 1,000 0,06240157 0,10464613 ! morphogenesis of an epithelium GO:0002009 63 62 1,000 0,06421388 0,10758743 GO:0060429|epithelium development, ! di-, tri-valent inorganic cation transport GO:0015674 63 62 1,000 0,06421388 0,10748971 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,06492548 0,10858226 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,06492548 0,10848382 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 0,000 0,06492548 0,10838556 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,06492548 0,10828747 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,06492548 0,10818956 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! neuron maturation GO:0042551 10 10 0,000 0,06492548 0,10809183 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,06492548 0,10799427 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,06492548 0,10789689 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,06492548 0,10779969 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,06492548 0,10770266 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,06492548 0,1076058 ! hormone secretion GO:0046879 10 10 0,000 0,06492548 0,10750912 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,06492548 0,10741262 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,06492548 0,10731628 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inositol metabolic process GO:0006020 10 10 0,000 0,06492548 0,10722012 ! cAMP metabolic process GO:0046058 10 10 0,000 0,06492548 0,10712413 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,06492548 0,10702831 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,06492548 0,10693267 ! glial cell development GO:0021782 10 10 0,000 0,06492548 0,10683719 ! phototransduction GO:0007602 11 10 0,000 0,06492548 0,10674189 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,06492548 0,10664675 ! fat cell differentiation GO:0045444 10 10 0,000 0,06492548 0,10655178 ! myoblast differentiation GO:0045445 10 10 0,000 0,06492548 0,10645699 ! centrosome cycle GO:0007098 10 10 0,000 0,06492548 0,10636236 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,06492548 0,1062679 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,06492548 0,10617361 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,06492548 0,10607948 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,06492548 0,10598552 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,06492548 0,10589173 ! protein polyubiquitination GO:0000209 10 10 0,000 0,06492548 0,1057981 ! glutamate metabolic process GO:0006536 11 10 0,000 0,06492548 0,10570464 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,06492548 0,10561134 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,06492548 0,10551821 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,06492548 0,10542525 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,06492548 0,10533244 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,06492548 0,1052398 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,06492548 0,10514732 ! exocrine system development GO:0035272 10 10 0,000 0,06492548 0,10505501 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,06492548 0,10496285 ! embryo implantation GO:0007566 11 10 0,000 0,06492548 0,10487086 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,06492548 0,10477903 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,06492548 0,10468736 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,06492548 0,10459585 ! protein export from nucleus GO:0006611 10 10 0,000 0,06492548 0,1045045 ! cytolysis GO:0019835 10 10 0,000 0,06492548 0,10441331 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,06492548 0,10432228 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,06492548 0,10423141 ! mRNA splice site selection GO:0006376 11 10 0,000 0,06492548 0,10414069 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,06492548 0,10405013 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,06492548 0,10395973 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,06492548 0,10386949 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,06492548 0,1037794 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,06492548 0,10368947 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,06492548 0,1035997 ! regulation of epidermis development GO:0045682 10 10 0,000 0,06492548 0,10351008 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,06492548 0,10342062 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,06492548 0,10333131 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,06492548 0,10324215 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,06492548 0,10315315 ! nerve development GO:0021675 10 10 0,000 0,06492548 0,1030643 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,06492548 0,10297561 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,06492548 0,10288706 ! positive regulation of neuron apoptosis GO:0043525 10 10 0,000 0,06492548 0,10279867 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,06492548 0,10271043 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,06492548 0,10262234 ! protein stabilization GO:0050821 10 10 0,000 0,06492548 0,10253441 ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,066044 0,10421156 ! regulation of cytoskeleton organization GO:0051493 66 64 1,000 0,06789164 0,10703533 ! positive regulation of protein metabolic process GO:0051247 64 64 1,000 0,06789164 0,10694384 ! anion transport GO:0006820 65 65 1,000 0,06975649 0,10978755 ! positive regulation of cellular component organization GO:0051130 65 65 1,000 0,06975649 0,10969387 ! protein secretion GO:0009306 11 11 0,000 0,07118653 0,11184721 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,07118653 0,11175194 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,07118653 0,11165683 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,07118653 0,11156188 ! negative regulation of defense response GO:0031348 11 11 0,000 0,07118653 0,1114671 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,07118653 0,11137247 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,07118653 0,11127801 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,07118653 0,11118371 ! skin development GO:0043588 11 11 0,000 0,07118653 0,11108956 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,07118653 0,11099558 ! signal complex assembly GO:0007172 11 11 0,000 0,07118653 0,11090175 ! endothelial cell migration GO:0043542 11 11 0,000 0,07118653 0,11080809 ! peroxisomal transport GO:0043574 11 11 0,000 0,07118653 0,11071458 ! protein amino acid methylation GO:0006479 11 11 0,000 0,07118653 0,11062123 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,07118653 0,11052803 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,07118653 0,11043499 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,07118653 0,11034211 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,07118653 0,11024939 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,07118653 0,11015682 ! spinal cord development GO:0021510 11 11 0,000 0,07118653 0,11006441 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,07118653 0,10997215 ! smooth muscle contraction GO:0006939 11 11 0,000 0,07118653 0,10988004 ! cellular response to starvation GO:0009267 11 11 0,000 0,07118653 0,10978809 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,07118653 0,1096963 ! digestive system process GO:0022600 11 11 0,000 0,07118653 0,10960466 ! mitotic spindle organization GO:0007052 11 11 0,000 0,07118653 0,10951317 ! fucose metabolic process GO:0006004 11 11 0,000 0,07118653 0,10942183 ! membrane budding GO:0006900 11 11 0,000 0,07118653 0,10933064 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,07118653 0,10923961 ! monoamine transport GO:0015844 11 11 0,000 0,07118653 0,10914873 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,07118653 0,109058 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,07118653 0,10896742 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 0,000 0,07118653 0,10887699 ! body fluid secretion GO:0007589 11 11 0,000 0,07118653 0,10878671 ! G1/S transition checkpoint GO:0031575 12 11 0,000 0,07118653 0,10869658 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,07118653 0,1086066 GO:0060415|muscle tissue morphogenesis, ! membrane depolarization GO:0051899 11 11 0,000 0,07118653 0,10851677 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,07118653 0,10842709 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,07118653 0,10833755 ! regulation of monooxygenase activity GO:0032768 11 11 0,000 0,07118653 0,10824816 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,07118653 0,10815892 ! vitamin transport GO:0051180 11 11 0,000 0,07118653 0,10806983 ! muscle maintenance GO:0046716 12 11 0,000 0,07118653 0,10798088 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,07118653 0,10789208 ! steroid catabolic process GO:0006706 11 11 0,000 0,07118653 0,10780343 ! endocrine process GO:0050886 11 11 0,000 0,07118653 0,10771492 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,07118653 0,10762656 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,07118653 0,10753834 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,07118653 0,10745026 ! polysaccharide metabolic process GO:0005976 69 66 1,000 0,07163826 0,10804362 ! negative regulation of cell differentiation GO:0045596 68 67 1,000 0,07353663 0,11081603 ! response to radiation GO:0009314 70 68 1,000 0,07545132 0,11360849 ! chromatin assembly or disassembly GO:0006333 68 68 1,000 0,07545132 0,11351574 ! regulation of translation GO:0006417 69 69 1,000 0,07738204 0,11632553 ! response to nutrient levels GO:0031667 69 69 1,000 0,07738204 0,11623072 ! translational initiation GO:0006413 12 12 0,000 0,07740656 0,11617288 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,07740656 0,11607835 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,07740656 0,11598398 ! initiation of viral infection GO:0019059 12 12 0,000 0,07740656 0,11588976 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,07740656 0,1157957 ! iron ion transport GO:0006826 13 12 0,000 0,07740656 0,11570178 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,07740656 0,11560802 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,07740656 0,11551441 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,07740656 0,11542095 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,07740656 0,11532765 ! collagen metabolic process GO:0032963 12 12 0,000 0,07740656 0,11523449 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,07740656 0,11514148 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,07740656 0,11504863 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,07740656 0,11495592 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,07740656 0,11486336 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,07740656 0,11477096 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,07740656 0,1146787 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,07740656 0,11458658 ! actomyosin structure organization GO:0031032 12 12 0,000 0,07740656 0,11449462 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,07740656 0,1144028 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,07740656 0,11431114 ! retinoid metabolic process GO:0001523 12 12 0,000 0,07740656 0,11421961 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,07740656 0,11412824 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,07740656 0,11403701 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,07740656 0,11394592 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,07740656 0,11385499 ! acute-phase response GO:0006953 12 12 0,000 0,07740656 0,11376419 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,07740656 0,11367354 ! vacuolar transport GO:0007034 12 12 0,000 0,07740656 0,11358304 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,07740656 0,11349268 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,07740656 0,11340246 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,07740656 0,11331239 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,07740656 0,11322246 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,07740656 0,11313267 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,07740656 0,11304302 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,07740656 0,11295352 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,07740656 0,11286416 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,07740656 0,11277494 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,07740656 0,11268586 ! pallium development GO:0021543 13 12 0,000 0,07740656 0,11259692 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,07740656 0,11250812 ! detection of light stimulus GO:0009583 13 12 0,000 0,07740656 0,11241946 ! synaptogenesis GO:0007416 12 12 0,000 0,07740656 0,11233094 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,07740656 0,11224256 ! hormone transport GO:0009914 12 12 0,000 0,07740656 0,11215432 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,07740656 0,11206622 ! heme biosynthetic process GO:0006783 12 12 0,000 0,07740656 0,11197826 ! spermatid differentiation GO:0048515 13 12 0,000 0,07740656 0,11189043 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,07740656 0,11180274 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,07740656 0,11171519 ! neural tube closure GO:0001843 13 12 0,000 0,07740656 0,11162778 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 0,000 0,07740656 0,1115405 ! positive regulation of transport GO:0051050 71 70 1,000 0,07932849 0,11422063 ! carboxylic acid biosynthetic process GO:0046394 70 70 1,000 0,07932849 0,11413147 GO:0016053|organic acid biosynthetic process, ! positive regulation of hydrolase activity GO:0051345 72 72 1,000 0,08326747 0,11970511 ! response to extracellular stimulus GO:0009991 72 72 1,000 0,08326747 0,11961181 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 0,000 0,08358584 0,11997563 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,08358584 0,11988227 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,08358584 0,11978904 ! phenol metabolic process GO:0018958 13 13 0,000 0,08358584 0,11969597 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,08358584 0,11960304 ! gluconeogenesis GO:0006094 13 13 0,000 0,08358584 0,11951025 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,08358584 0,11941761 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,08358584 0,11932511 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,08358584 0,11923275 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,08358584 0,11914053 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,08358584 0,11904846 ! keratinization GO:0031424 13 13 0,000 0,08358584 0,11895653 ! patterning of blood vessels GO:0001569 13 13 0,000 0,08358584 0,11886475 ! regulation of innate immune response GO:0045088 13 13 0,000 0,08358584 0,1187731 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,08358584 0,1186816 ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,08358584 0,11859023 ! autophagy GO:0006914 13 13 0,000 0,08358584 0,11849901 ! receptor metabolic process GO:0043112 14 13 0,000 0,08358584 0,11840793 ! negative regulation of protein catabolic process GO:0042177 13 13 0,000 0,08358584 0,11831698 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 0,000 0,08358584 0,11822618 ! regulation of endothelial cell migration GO:0010594 13 13 0,000 0,08358584 0,11813551 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,08358584 0,11804499 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,08358584 0,1179546 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,08358584 0,11786435 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,08358584 0,11777424 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,08358584 0,11768427 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,08358584 0,11759444 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,08358584 0,11750474 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,08358584 0,11741518 ! vasodilation GO:0042311 14 13 0,000 0,08358584 0,11732575 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,08358584 0,11723646 GO:0006664|glycolipid metabolic process, ! positive regulation of locomotion GO:0040017 13 13 0,000 0,08358584 0,11714731 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! neural crest cell migration GO:0001755 14 13 0,000 0,08358584 0,11705829 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,08358584 0,11696941 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,08358584 0,11688066 ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,08358584 0,11679205 ! cell-cell junction organization GO:0045216 13 13 0,000 0,08358584 0,11670357 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,08358584 0,11661522 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,08358584 0,11652701 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,08358584 0,11643894 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,08358584 0,11635099 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,08358584 0,11626318 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,08358584 0,1161755 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,08358584 0,11608795 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,08358584 0,11600054 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,08358584 0,11591325 ! blastocyst development GO:0001824 13 13 0,000 0,08358584 0,1158261 ! telomere organization GO:0032200 13 13 0,000 0,08358584 0,11573908 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,08358584 0,11565219 ! regulation of amine transport GO:0051952 13 13 0,000 0,08358584 0,11556542 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,08972463 0,12395989 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,08972463 0,12386704 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,08972463 0,12377432 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,08972463 0,12368175 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,08972463 0,12358931 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,08972463 0,12349701 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,08972463 0,12340485 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,08972463 0,12331282 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,08972463 0,12322094 ! vesicle docking GO:0048278 14 14 0,000 0,08972463 0,12312919 ! superoxide metabolic process GO:0006801 15 14 0,000 0,08972463 0,12303757 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,08972463 0,12294609 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,08972463 0,12285475 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,08972463 0,12276355 ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,08972463 0,12267247 ! response to retinoic acid GO:0032526 14 14 0,000 0,08972463 0,12258154 GO:0033189|response to vitamin A, ! lysosome organization GO:0007040 14 14 0,000 0,08972463 0,12249074 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,08972463 0,12240007 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,08972463 0,12230954 ! peptide transport GO:0015833 14 14 0,000 0,08972463 0,12221914 ! primary neural tube formation GO:0014020 15 14 0,000 0,08972463 0,12212887 ! peptide cross-linking GO:0018149 14 14 0,000 0,08972463 0,12203874 ! regulation of behavior GO:0050795 14 14 0,000 0,08972463 0,12194874 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,08972463 0,12185888 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,08972463 0,12176914 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,08972463 0,12167954 ! formation of primary germ layer GO:0001704 14 14 0,000 0,08972463 0,12159007 GO:0001707|mesoderm formation, ! collagen fibril organization GO:0030199 14 14 0,000 0,08972463 0,12150073 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,08972463 0,12141152 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,08972463 0,12132245 ! positive regulation of inflammatory response GO:0050729 14 14 0,000 0,08972463 0,1212335 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,08972463 0,12114469 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,08972463 0,121056 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,08972463 0,12096744 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,08972463 0,12087902 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,08972463 0,12079072 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,08972463 0,12070255 ! positive regulation of multicellular organismal process GO:0051240 76 76 1,000 0,09132189 0,12276167 ! regulation of protein modification process GO:0031399 79 78 1,000 0,09543297 0,12819458 ! positive regulation of protein kinase cascade GO:0010740 79 78 1,000 0,09543297 0,12810121 ! regulation of immune response GO:0050776 78 78 1,000 0,09543297 0,12800798 ! protein import into nucleus, translocation GO:0000060 15 15 0,000 0,09582318 0,12843791 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,09582318 0,12834457 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,09582318 0,12825136 ! positive regulation of ossification GO:0045778 15 15 0,000 0,09582318 0,12815829 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,09582318 0,12806536 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,09582318 0,12797256 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,09582318 0,12787989 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,09582318 0,12778736 ! response to vitamin GO:0033273 15 15 0,000 0,09582318 0,12769496 ! regulation of transcription factor import into nucleus GO:0042990 15 15 0,000 0,09582318 0,12760269 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,09582318 0,12751056 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,09582318 0,12741856 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,09582318 0,1273267 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,09582318 0,12723496 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,09582318 0,12714336 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,09582318 0,12705189 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,09582318 0,12696055 ! heme metabolic process GO:0042168 15 15 0,000 0,09582318 0,12686935 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,09582318 0,12677827 ! chromosome condensation GO:0030261 15 15 0,000 0,09582318 0,12668732 ! response to starvation GO:0042594 15 15 0,000 0,09582318 0,12659651 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,09582318 0,12650582 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,09582318 0,12641527 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,09582318 0,12632484 GO:0030500|regulation of bone mineralization, ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,09582318 0,12623455 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,09582318 0,12614438 ! phospholipid transport GO:0015914 15 15 0,000 0,09582318 0,12605434 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,09582318 0,12596443 ! glutathione metabolic process GO:0006749 16 15 0,000 0,09582318 0,12587465 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,09582318 0,12578499 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,09582318 0,12569547 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,09582318 0,12560607 ! negative regulation of transcription factor activity GO:0043433 16 15 0,000 0,09582318 0,12551679 GO:0090048|negative regulation of transcription regulator activity, ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,09582318 0,12542765 ! protein homooligomerization GO:0051260 15 15 0,000 0,09582318 0,12533863 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,10188176 0,13316886 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 0,000 0,10188176 0,13307448 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! alkaloid metabolic process GO:0009820 16 16 0,000 0,10188176 0,13298023 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,10188176 0,13288612 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,10188176 0,13279214 ! learning GO:0007612 16 16 0,000 0,10188176 0,1326983 ! circadian rhythm GO:0007623 16 16 0,000 0,10188176 0,13260458 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,10188176 0,132511 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 0,000 0,10188176 0,13241755 ! vacuole organization GO:0007033 16 16 0,000 0,10188176 0,13232423 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,10188176 0,13223105 ! vesicle targeting GO:0006903 17 16 0,000 0,10188176 0,13213799 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,10188176 0,13204507 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,10188176 0,13195228 ! iron ion homeostasis GO:0055072 16 16 0,000 0,10188176 0,13185961 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,10188176 0,13176708 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,10188176 0,13167468 ! cell fate specification GO:0001708 16 16 0,000 0,10188176 0,1315824 ! pentose metabolic process GO:0019321 16 16 0,000 0,10188176 0,13149026 ! fatty acid transport GO:0015908 16 16 0,000 0,10188176 0,13139824 ! cellular response to nutrient levels GO:0031669 16 16 0,000 0,10188176 0,13130635 ! cofactor catabolic process GO:0051187 16 16 0,000 0,10188176 0,1312146 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,10188176 0,13112297 ! polyol metabolic process GO:0019751 16 16 0,000 0,10188176 0,13103146 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,10188176 0,13094009 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,10188176 0,13084884 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,10188176 0,13075772 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,10188176 0,13066673 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,10188176 0,13057586 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,10188176 0,13048512 ! regulation of coagulation GO:0050818 17 16 0,000 0,10188176 0,13039451 ! blood vessel morphogenesis GO:0048514 84 83 1,000 0,10593839 0,13549233 ! regulation of fibroblast proliferation GO:0048145 17 17 0,000 0,10790062 0,13790627 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 0,000 0,10790062 0,1378107 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,10790062 0,13771526 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,10790062 0,13761996 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,10790062 0,13752479 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,10790062 0,13742975 ! sensory perception of smell GO:0007608 17 17 0,000 0,10790062 0,13733484 ! tissue remodeling GO:0048771 17 17 0,000 0,10790062 0,13724006 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,10790062 0,13714541 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,10790062 0,13705089 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,10790062 0,1369565 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,10790062 0,13686225 ! neural crest cell development GO:0014032 19 17 0,000 0,10790062 0,13676812 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 18 17 0,000 0,10790062 0,13667412 GO:0050768|negative regulation of neurogenesis, ! cell recognition GO:0008037 18 17 0,000 0,10790062 0,13658025 ! regulation of oxidoreductase activity GO:0051341 17 17 0,000 0,10790062 0,13648651 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,10790062 0,1363929 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,10790062 0,13629941 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,10790062 0,13620606 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,10790062 0,13611283 ! adult locomotory behavior GO:0008344 17 17 0,000 0,10790062 0,13601973 ! embryonic organ development GO:0048568 17 17 0,000 0,10790062 0,13592675 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,10790062 0,13583391 ! gene silencing GO:0016458 17 17 0,000 0,10790062 0,13574119 ! nitrogen compound biosynthetic process GO:0044271 86 85 1,000 0,11022629 0,13857235 ! positive regulation of response to stimulus GO:0048584 86 85 1,000 0,11022629 0,13847789 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,11388001 0,14297061 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,11388001 0,14287329 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,11388001 0,1427761 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 0,000 0,11388001 0,14267904 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,11388001 0,14258211 ! membrane docking GO:0022406 18 18 0,000 0,11388001 0,14248531 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,11388001 0,14238865 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,11388001 0,14229211 ! cholesterol homeostasis GO:0042632 18 18 0,000 0,11388001 0,14219571 GO:0055092|sterol homeostasis, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 0,000 0,11388001 0,14209943 ! striated muscle contraction GO:0006941 18 18 0,000 0,11388001 0,14200329 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,11388001 0,14190728 GO:0006639|acylglycerol metabolic process, ! negative regulation of DNA binding GO:0043392 19 18 0,000 0,11388001 0,14181139 ! ceramide metabolic process GO:0006672 18 18 0,000 0,11388001 0,14171564 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,11388001 0,14162002 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,11388001 0,14152452 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,11388001 0,14142915 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,11388001 0,14133391 ! cellular response to extracellular stimulus GO:0031668 18 18 0,000 0,11388001 0,1412388 ! BMP signaling pathway GO:0030509 18 18 0,000 0,11388001 0,14114382 ! negative regulation of catabolic process GO:0009895 18 18 0,000 0,11388001 0,14104897 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,11388001 0,14095424 ! chemotaxis GO:0006935 90 89 1,000 0,11893828 0,14711627 GO:0042330|taxis, ! DNA damage checkpoint GO:0000077 19 19 0,000 0,11982019 0,14810772 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,11982019 0,14800846 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 19 19 0,000 0,11982019 0,14790932 ! regulation of pH GO:0006885 19 19 0,000 0,11982019 0,14781032 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,11982019 0,14771145 ! feeding behavior GO:0007631 19 19 0,000 0,11982019 0,14761271 ! regulation of endothelial cell proliferation GO:0001936 19 19 0,000 0,11982019 0,14751411 ! peroxisome organization GO:0007031 19 19 0,000 0,11982019 0,14741563 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,11982019 0,14731729 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,11982019 0,14721908 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,11982019 0,147121 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,11982019 0,14702305 ! eye morphogenesis GO:0048592 19 19 0,000 0,11982019 0,14692523 ! regulation of cell shape GO:0008360 21 19 0,000 0,11982019 0,14682754 ! placenta development GO:0001890 19 19 0,000 0,11982019 0,14672998 ! vesicle localization GO:0051648 20 19 0,000 0,11982019 0,14663255 ! negative regulation of cell cycle GO:0045786 92 91 1,000 0,12335855 0,15086251 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 1,000 0,12558395 0,15348224 ! positive regulation of immune system process GO:0002684 92 92 1,000 0,12558395 0,15338053 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,12572141 0,15344673 ! negative regulation of binding GO:0051100 21 20 0,000 0,12572141 0,15334518 ! organic ether metabolic process GO:0018904 20 20 0,000 0,12572141 0,15324376 GO:0006662|glycerol ether metabolic process, ! nucleus organization GO:0006997 20 20 0,000 0,12572141 0,15314247 ! phagocytosis GO:0006909 21 20 0,000 0,12572141 0,15304132 ! positive regulation of gene-specific transcription GO:0043193 20 20 0,000 0,12572141 0,15294031 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,12572141 0,15283942 ! protein targeting to membrane GO:0006612 22 20 0,000 0,12572141 0,15273867 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,12572141 0,15263805 ! chromatin remodeling GO:0006338 20 20 0,000 0,12572141 0,15253757 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,12572141 0,15243721 ! lipid oxidation GO:0034440 20 20 0,000 0,12572141 0,15233699 GO:0019395|fatty acid oxidation, ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,12572141 0,1522369 ! RNA modification GO:0009451 20 20 0,000 0,12572141 0,15213694 ! single fertilization GO:0007338 21 20 0,000 0,12572141 0,15203712 ! tissue morphogenesis GO:0048729 94 93 1,000 0,12781922 0,15447267 ! blood vessel development GO:0001568 95 94 1,000 0,13006414 0,1570827 ! epidermis development GO:0008544 94 94 1,000 0,13006414 0,15697983 ! mRNA catabolic process GO:0006402 21 21 0,000 0,13158392 0,15871019 ! protein amino acid lipidation GO:0006497 21 21 0,000 0,13158392 0,15860639 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,13158392 0,15850273 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,13158392 0,1583992 ! ear morphogenesis GO:0042471 21 21 0,000 0,13158392 0,1582958 ! organic anion transport GO:0015711 21 21 0,000 0,13158392 0,15819254 ! cholesterol transport GO:0030301 21 21 0,000 0,13158392 0,15808942 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,13158392 0,15798643 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,13158392 0,15788357 GO:0032313|regulation of Rab GTPase activity, ! regulation of protein import into nucleus GO:0042306 21 21 0,000 0,13158392 0,15778085 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,13158392 0,15767826 ! regulation of proteolysis GO:0030162 21 21 0,000 0,13158392 0,15757581 ! negative regulation of hydrolase activity GO:0051346 21 21 0,000 0,13158392 0,15747349 ! vasculature development GO:0001944 97 96 1,000 0,13458203 0,16095697 ! RNA export from nucleus GO:0006405 22 22 0,000 0,13740797 0,16423015 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,13740797 0,16412371 ! regulation of ion transport GO:0043269 22 22 0,000 0,13740797 0,16401741 ! odontogenesis GO:0042476 22 22 0,000 0,13740797 0,16391125 ! hormone-mediated signaling GO:0009755 22 22 0,000 0,13740797 0,16380523 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,13740797 0,16369935 ! maintenance of protein location in cell GO:0032507 23 22 0,000 0,13740797 0,1635936 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,13740797 0,16348798 ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,13740797 0,16338251 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,13740797 0,16327717 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,13740797 0,16317196 ! detection of external stimulus GO:0009581 23 22 0,000 0,13740797 0,1630669 ! neuron migration GO:0001764 22 22 0,000 0,13740797 0,16296196 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,13740797 0,16285716 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,13740797 0,1627525 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,13740797 0,16264797 ! aerobic respiration GO:0009060 22 22 0,000 0,13740797 0,16254357 ! cytokine production GO:0001816 22 22 0,000 0,13740797 0,16243931 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,13740797 0,16233518 ! ectoderm development GO:0007398 99 99 1,000 0,14142578 0,16697483 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,1431938 0,16895402 ! viral infectious cycle GO:0019058 23 23 0,000 0,1431938 0,16884592 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,1431938 0,16873796 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,1431938 0,16863014 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,1431938 0,16852246 ! mitotic cell cycle checkpoint GO:0007093 24 23 0,000 0,1431938 0,16841492 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,1431938 0,16830751 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,1431938 0,16820024 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,1431938 0,16809311 ! monovalent inorganic cation homeostasis GO:0055067 23 23 0,000 0,1431938 0,16798611 ! lipid homeostasis GO:0055088 23 23 0,000 0,1431938 0,16787925 ! calcium-mediated signaling GO:0019722 23 23 0,000 0,1431938 0,16777252 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,1431938 0,16766593 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,1431938 0,16755948 ! cell projection assembly GO:0030031 25 23 0,000 0,1431938 0,16745316 ! gliogenesis GO:0042063 24 24 0,000 0,14894166 0,17406435 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,14894166 0,17395405 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,14894166 0,17384388 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,14894166 0,17373385 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,14894166 0,17362396 ! fertilization GO:0009566 25 24 0,000 0,14894166 0,17351421 ! maintenance of protein location GO:0045185 25 24 0,000 0,14894166 0,1734046 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,14894166 0,17329513 ! androgen receptor signaling pathway GO:0030521 24 24 0,000 0,14894166 0,17318579 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,1546518 0,17971202 ! negative regulation of secretion GO:0051048 26 25 0,000 0,1546518 0,17959878 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,1546518 0,17948568 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,1546518 0,17937273 ! cellular component disassembly GO:0022411 26 25 0,000 0,1546518 0,17925991 ! endosome transport GO:0016197 25 25 0,000 0,1546518 0,17914724 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,1546518 0,17903471 ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,1546518 0,17892232 ! excretion GO:0007588 25 25 0,000 0,1546518 0,17881008 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,1546518 0,17869797 ! gastrulation GO:0007369 25 25 0,000 0,1546518 0,178586 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,1546518 0,17847418 ! regulation of endocytosis GO:0030100 25 25 0,000 0,1546518 0,17836249 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,1546518 0,17825095 ! positive regulation of cytokine production GO:0001819 25 25 0,000 0,1546518 0,17813954 ! positive regulation of defense response GO:0031349 26 26 0,000 0,16032445 0,18455837 ! glycolysis GO:0006096 26 26 0,000 0,16032445 0,18444317 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,16032445 0,18432811 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 0,000 0,16032445 0,18421319 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,16032445 0,18409842 ! induction of apoptosis by intracellular signals GO:0008629 26 26 0,000 0,16032445 0,18398378 ! cellular defense response GO:0006968 26 26 0,000 0,16032445 0,18386929 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,16032445 0,18375495 ! double-strand break repair GO:0006302 27 26 0,000 0,16032445 0,18364074 ! regulation of protein secretion GO:0050708 26 26 0,000 0,16032445 0,18352668 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,16032445 0,18341276 GO:0035150|regulation of tube size, ! maintenance of location in cell GO:0051651 27 26 0,000 0,16032445 0,18329898 ! chloride transport GO:0006821 27 27 0,000 0,16595985 0,18962431 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,16595985 0,18950682 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,16595985 0,18938948 ! cAMP-mediated signaling GO:0019933 27 27 0,000 0,16595985 0,18927228 ! peptide metabolic process GO:0006518 29 27 0,000 0,16595985 0,18915523 ! activation of caspase activity GO:0006919 27 27 0,000 0,16595985 0,18903833 ! defense response to bacterium GO:0042742 27 27 0,000 0,16595985 0,18892156 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,16595985 0,18880495 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,16595985 0,18868847 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,17155826 0,19493333 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,17155826 0,19481323 GO:0007254|JNK cascade, ! neuromuscular process GO:0050905 28 28 0,000 0,17155826 0,19469327 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,17155826 0,19457346 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,17155826 0,19445379 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,17155826 0,19433427 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,17155826 0,1942149 ! cartilage development GO:0051216 29 28 0,000 0,17155826 0,19409568 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,17711989 0,200265 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,17711989 0,20014222 ! antigen processing and presentation GO:0019882 29 29 0,000 0,17711989 0,20001958 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,17711989 0,1998971 ! tRNA processing GO:0008033 29 29 0,000 0,17711989 0,19977476 ! adult behavior GO:0030534 30 29 0,000 0,17711989 0,19965257 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,17711989 0,19953054 ! transition metal ion transport GO:0000041 31 30 0,000 0,18264499 0,20562903 ! RNA catabolic process GO:0006401 30 30 0,000 0,18264499 0,20550349 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,18264499 0,20537811 ! positive regulation of peptidase activity GO:0010952 30 30 0,000 0,18264499 0,20525288 GO:0043280|positive regulation of caspase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,18264499 0,2051278 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,18264499 0,20500288 ! activation of phospholipase C activity GO:0007202 30 30 0,000 0,18264499 0,2048781 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,18264499 0,20475348 ! positive regulation of response to external stimulus GO:0032103 30 30 0,000 0,18264499 0,20462901 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,18264499 0,20450469 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,18264499 0,20438052 ! vascular process in circulatory system GO:0003018 31 30 0,000 0,18264499 0,20425651 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,18264499 0,20413264 GO:0019724|B cell mediated immunity, ! regulation of inflammatory response GO:0050727 30 30 0,000 0,18264499 0,20400892 ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,18264499 0,20388536 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,18264499 0,20376194 ! regulation of translational initiation GO:0006446 31 31 0,000 0,1881338 0,20975838 ! membrane fusion GO:0006944 31 31 0,000 0,1881338 0,20963156 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,1881338 0,20950489 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,1881338 0,20937838 ! positive regulation of phospholipase activity GO:0010518 31 31 0,000 0,1881338 0,20925202 ! ion transmembrane transport GO:0034220 31 31 0,000 0,1881338 0,20912581 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,1881338 0,20899976 ! digestion GO:0007586 31 31 0,000 0,1881338 0,20887385 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,1881338 0,2087481 ! regulation of heart contraction GO:0008016 31 31 0,000 0,1881338 0,2086225 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,1881338 0,20849705 ! camera-type eye development GO:0043010 31 31 0,000 0,1881338 0,20837175 ! extracellular matrix organization GO:0030198 31 31 0,000 0,1881338 0,2082466 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,1881338 0,20812161 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,1881338 0,20799676 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,1881338 0,20787206 ! cell redox homeostasis GO:0045454 32 32 0,000 0,19358655 0,21376873 ! glucose catabolic process GO:0006007 32 32 0,000 0,19358655 0,21364072 ! lipid modification GO:0030258 32 32 0,000 0,19358655 0,21351287 ! regulation of phospholipase activity GO:0010517 32 32 0,000 0,19358655 0,21338517 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,19358655 0,21325762 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,19358655 0,21313023 ! nuclear export GO:0051168 32 32 0,000 0,19358655 0,21300299 ! positive regulation of lipase activity GO:0060193 32 32 0,000 0,19358655 0,2128759 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,19358655 0,21274896 ! maintenance of location GO:0051235 33 32 0,000 0,19358655 0,21262217 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,19900346 0,21844156 ! amino acid transport GO:0006865 33 33 0,000 0,19900346 0,21831153 ! activation of protein kinase activity GO:0032147 35 33 0,000 0,19900346 0,21818166 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,19900346 0,21805195 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,19900346 0,21792238 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,19900346 0,21779298 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,19900346 0,21766372 ! regulation of actin filament length GO:0030832 34 34 0,000 0,20438477 0,22341704 ! muscle cell differentiation GO:0042692 35 34 0,000 0,20438477 0,22328461 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,20438477 0,22315233 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,20438477 0,22302021 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,20438477 0,22288824 ! detection of stimulus GO:0051606 36 34 0,000 0,20438477 0,22275643 ! acute inflammatory response GO:0002526 35 35 0,000 0,20973071 0,22844781 ! regulation of cellular component size GO:0032535 35 35 0,000 0,20973071 0,22831287 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,20973071 0,2281781 ! mesoderm development GO:0007498 35 35 0,000 0,20973071 0,22804348 ! regulation of cell morphogenesis GO:0022604 38 35 0,000 0,20973071 0,22790902 ! positive regulation of phosphorylation GO:0042327 35 35 0,000 0,20973071 0,22777472 ! inorganic anion transport GO:0015698 35 35 0,000 0,20973071 0,22764058 ! hydrogen transport GO:0006818 36 36 0,000 0,2150415 0,23326751 GO:0015992|proton transport, ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,2150415 0,23313029 ! positive regulation of phosphorus metabolic process GO:0010562 36 36 0,000 0,2150415 0,23299323 GO:0045937|positive regulation of phosphate metabolic process, ! heterocycle catabolic process GO:0046700 36 36 0,000 0,2150415 0,23285634 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,2150415 0,23271961 ! regulation of lipase activity GO:0060191 36 36 0,000 0,2150415 0,23258303 ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,22031738 0,23814952 ! eye development GO:0001654 37 37 0,000 0,22031738 0,23800992 ! DNA damage response, signal transduction GO:0042770 37 37 0,000 0,22031738 0,23787049 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,22031738 0,23773122 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,22031738 0,23759212 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,22031738 0,23745318 ! adaptive immune response GO:0002250 37 37 0,000 0,22031738 0,23731439 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of secretion GO:0051047 39 38 0,000 0,22555856 0,24281801 ! neurotransmitter transport GO:0006836 40 38 0,000 0,22555856 0,24267626 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,22555856 0,24253467 ! exocytosis GO:0006887 40 38 0,000 0,22555856 0,24239325 ! hexose catabolic process GO:0019320 38 38 0,000 0,22555856 0,242252 ! regulation of neurological system process GO:0031644 38 38 0,000 0,22555856 0,24211091 ! steroid hormone receptor signaling pathway GO:0030518 38 38 0,000 0,22555856 0,24196998 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,23076527 0,24741151 ! response to unfolded protein GO:0006986 39 39 0,000 0,23076527 0,24726767 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,23076527 0,24712399 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,23076527 0,24698048 ! cytokine-mediated signaling pathway GO:0019221 39 39 0,000 0,23076527 0,24683714 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,23076527 0,24669396 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 0,000 0,23593773 0,25207724 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,23593773 0,25193119 ! amine catabolic process GO:0009310 42 41 0,000 0,24107616 0,25726888 ! regulation of caspase activity GO:0043281 41 41 0,000 0,24107616 0,25712 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,24107616 0,25697129 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,24107616 0,25682275 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,24107616 0,25667439 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,24107616 0,25652619 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,24618078 0,2618068 ! regulation of endopeptidase activity GO:0052548 42 42 0,000 0,24618078 0,26165581 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,24618078 0,261505 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 0,000 0,25125181 0,26673795 ! alcohol catabolic process GO:0046164 43 43 0,000 0,25125181 0,26658439 ! mRNA transport GO:0051028 44 44 0,000 0,25628946 0,271773 ! protein import into nucleus GO:0006606 44 44 0,000 0,25628946 0,27161672 ! vitamin metabolic process GO:0006766 44 44 0,000 0,25628946 0,27146061 ! homophilic cell adhesion GO:0007156 45 45 0,000 0,26129395 0,27660238 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,26129395 0,2764436 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,26129395 0,27628499 ! nuclear import GO:0051170 45 45 0,000 0,26129395 0,27612657 ! protein processing GO:0016485 45 45 0,000 0,26129395 0,27596833 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,26626549 0,28105801 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 0,000 0,26626549 0,28089713 ! regulation of peptidase activity GO:0052547 46 46 0,000 0,26626549 0,28073644 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,27120429 0,28578016 ! regulation of blood pressure GO:0008217 48 47 0,000 0,27120429 0,28561686 ! amine transport GO:0015837 47 47 0,000 0,27120429 0,28545375 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,27611057 0,29045193 ! protein localization in nucleus GO:0034504 48 48 0,000 0,27611057 0,29028624 ! DNA recombination GO:0006310 48 48 0,000 0,27611057 0,29012074 ! ossification GO:0001503 50 49 0,000 0,28098453 0,29507379 GO:0060348|bone development, ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,28098453 0,29490575 ! response to bacterium GO:0009617 50 49 0,000 0,28098453 0,2947379 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,28098453 0,29457025 ! regulation of defense response GO:0031347 50 50 0,000 0,28582639 0,29947586 ! chromatin assembly GO:0031497 50 50 0,000 0,28582639 0,2993057 GO:0006334|nucleosome assembly, ! RNA transport GO:0050658 50 50 0,000 0,28582639 0,29913574 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 0,000 0,28582639 0,29896597 ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,28582639 0,29879639 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,29063634 0,30365237 ! rRNA metabolic process GO:0016072 51 51 0,000 0,29063634 0,30348033 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,29063634 0,30330848 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,29063634 0,30313683 ! protein maturation GO:0051604 51 51 0,000 0,29063634 0,30296537 ! RNA localization GO:0006403 52 52 0,000 0,2954146 0,30777225 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,2954146 0,30759837 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 0,000 0,2954146 0,30742468 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,2954146 0,30725119 ! tRNA metabolic process GO:0006399 53 53 0,000 0,30016137 0,31201207 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,30016137 0,31183619 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,30016137 0,31166051 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,30016137 0,31148502 ! hormone metabolic process GO:0042445 55 54 0,000 0,30487685 0,31620035 ! sulfur metabolic process GO:0006790 55 54 0,000 0,30487685 0,31602251 ! nucleosome organization GO:0034728 55 55 0,000 0,30956124 0,32069779 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,30956124 0,32051762 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! in utero embryonic development GO:0001701 55 55 0,000 0,30956124 0,32033766 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,31421475 0,32497069 ! ATP metabolic process GO:0046034 57 57 0,000 0,31883757 0,32956682 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,31883757 0,32938208 ! innate immune response GO:0045087 58 58 0,000 0,3234299 0,3339391 ! carboxylic acid transport GO:0046942 59 59 0,000 0,32799193 0,33845976 GO:0015849|organic acid transport, ! sterol metabolic process GO:0016125 59 59 0,000 0,32799193 0,33827036 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,32799193 0,33808117 ! protein localization in organelle GO:0033365 59 59 0,000 0,32799193 0,33789219 ! potassium ion transport GO:0006813 60 60 0,000 0,33252388 0,34236955 ! cellular respiration GO:0045333 62 61 0,000 0,33702591 0,34681114 ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,33702591 0,34661761 GO:0016054|organic acid catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,33702591 0,34642429 ! lipid transport GO:0006869 62 62 0,000 0,34149824 0,35082568 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,34149824 0,35063023 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,34149824 0,350435 ! protein import GO:0017038 62 62 0,000 0,34149824 0,35023999 ! regulation of secretion GO:0051046 65 63 0,000 0,34594105 0,3545992 ! glucose metabolic process GO:0006006 63 63 0,000 0,34594105 0,35440209 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,34594105 0,3542052 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,34594105 0,35400853 ! glycerolipid metabolic process GO:0046486 65 64 0,000 0,35035454 0,35832598 ! regulation of response to external stimulus GO:0032101 65 64 0,000 0,35035454 0,35812724 ! angiogenesis GO:0001525 65 64 0,000 0,35035454 0,35792872 ! regulation of hormone levels GO:0010817 66 65 0,000 0,35473888 0,36220707 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,35909427 0,36645113 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,35909427 0,36624834 ! DNA packaging GO:0006323 66 66 0,000 0,35909427 0,36604577 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,36342091 0,37025137 ! muscle contraction GO:0006936 67 67 0,000 0,36342091 0,37004681 ! Ras protein signal transduction GO:0007265 69 67 0,000 0,36342091 0,36984248 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,36771896 0,37400996 ! sensory perception of sound GO:0007605 71 69 0,000 0,37198862 0,37814397 GO:0050954|sensory perception of mechanical stimulus, ! translational elongation GO:0006414 71 71 0,000 0,38044349 0,38652556 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,38044349 0,3863126 ! ribosome biogenesis GO:0042254 71 71 0,000 0,38044349 0,38609987 ! secretion by cell GO:0032940 75 72 0,000 0,38462907 0,39013285 ! muscle system process GO:0003012 72 72 0,000 0,38462907 0,38991825 ! regulation of cytokine production GO:0001817 72 72 0,000 0,38462907 0,38970389 ! electron transport chain GO:0022900 75 74 0,000 0,39291741 0,39788285 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,39291741 0,39766435 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,39702052 0,4015965 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,39702052 0,40137621 ! nuclear transport GO:0051169 79 79 0,000 0,4131634 0,41746719 GO:0006913|nucleocytoplasmic transport, ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,41713259 0,42124678 ! lipid catabolic process GO:0016042 82 81 0,000 0,42107552 0,42499572 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,42888325 0,43263921 ! ncRNA processing GO:0034470 83 83 0,000 0,42888325 0,43240254 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,43274839 0,43606085 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,44040207 0,4435306 GO:0006644|phospholipid metabolic process, ! hexose metabolic process GO:0019318 87 86 0,000 0,44040207 0,44328837 ! male gamete generation GO:0048232 90 88 0,000 0,44795468 0,45064437 GO:0007283|spermatogenesis, ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,44795468 0,45039852 ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,45540755 0,45764238 ! DNA replication GO:0006260 91 91 0,000 0,45909699 0,4610985 ! visual perception GO:0007601 93 92 0,000 0,46276197 0,46452631 GO:0050953|sensory perception of light stimulus, ! fatty acid metabolic process GO:0006631 93 92 0,000 0,46276197 0,46427344 ! regulation of response to stress GO:0080134 97 94 0,000 0,47001919 0,47129781 ! cofactor metabolic process GO:0051186 95 94 0,000 0,47001919 0,47104153 ! endocytosis GO:0006897 99 98 0,000 0,48424709 0,48503662 GO:0010324|membrane invagination, ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,48424709 0,48477316 ! blood circulation GO:0008015 99 98 0,000 0,48424709 0,48450998 GO:0003013|circulatory system process, ! regulation of system process GO:0044057 98 98 0,000 0,48424709 0,48424709