pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6607-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 6,000 2,121E-08 5,102E-05 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 5,000 1,549E-07 1,864E-04 ! insulin receptor signaling pathway GO:0008286 64 26 4,000 2,316E-07 1,857E-04 ! regulation of B cell proliferation GO:0030888 20 12 3,000 3,583E-07 2,155E-04 ! interphase of mitotic cell cycle GO:0051329 209 95 6,000 7,494E-07 3,606E-04 ! response to peptide hormone stimulus GO:0043434 122 61 5,000 8,604E-07 3,45E-04 ! regulation of DNA metabolic process GO:0051052 178 97 6,000 8,636E-07 2,968E-04 ! interphase GO:0051325 213 98 6,000 9,259E-07 2,785E-04 ! L-serine biosynthetic process GO:0006564 6 5 2,000 1,433E-06 3,83E-04 ! phospholipid scrambling GO:0017121 8 5 2,000 1,433E-06 3,447E-04 ! cellular response to insulin stimulus GO:0032869 82 37 4,000 1,464E-06 3,203E-04 ! cell-substrate junction assembly GO:0007044 54 18 3,000 2,161E-06 4,332E-04 ! T cell differentiation GO:0030217 81 41 4,000 2,475E-06 4,58E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 3,393E-06 5,831E-04 ! response to insulin stimulus GO:0032868 95 46 4,000 4,432E-06 7,108E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 4,976E-06 7,482E-04 ! regulation of mast cell proliferation GO:0070666 81 48 4,000 5,489E-06 7,768E-04 ! negative regulation of phosphorylation GO:0042326 47 24 3,000 7,32E-06 9,784E-04 ! regulation of leukocyte proliferation GO:0070663 88 51 4,000 7,434E-06 9,414E-04 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! gland development GO:0048732 206 88 5,000 7,468E-06 8,984E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 7,931E-06 9,086E-04 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 7,931E-06 8,673E-04 ! regulation of cell cycle process GO:0010564 149 90 5,000 8,505E-06 8,897E-04 ! response to UV GO:0009411 104 53 4,000 9,005E-06 9,028E-04 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 3,000 1,021E-05 9,83E-04 GO:0045936|negative regulation of phosphate metabolic process, ! nucleotide-excision repair GO:0006289 83 56 4,000 1,183E-05 1,095E-03 ! regulation of DNA replication GO:0006275 101 56 4,000 1,183E-05 1,055E-03 ! T cell selection GO:0045058 23 9 2,000 1,185E-05 1,018E-03 ! DNA catabolic process GO:0006308 86 59 4,000 1,531E-05 1,271E-03 ! integrin-mediated signaling pathway GO:0007229 135 59 4,000 1,531E-05 1,228E-03 ! cell cycle arrest GO:0007050 213 100 5,000 1,559E-05 1,21E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 1,686E-05 1,268E-03 ! positive regulation of B cell proliferation GO:0030890 16 10 2,000 1,686E-05 1,229E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 1,686E-05 1,193E-03 ! L-serine metabolic process GO:0006563 18 10 2,000 1,686E-05 1,159E-03 ! oocyte development GO:0048599 17 10 2,000 1,686E-05 1,127E-03 ! cell junction assembly GO:0034329 78 30 3,000 1,842E-05 1,198E-03 ! regulation of B cell activation GO:0050864 50 30 3,000 1,842E-05 1,166E-03 ! oocyte differentiation GO:0009994 18 11 2,000 2,31E-05 1,425E-03 ! focal adhesion formation GO:0048041 35 12 2,000 3,067E-05 1,845E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 3,067E-05 1,8E-03 GO:0042130|negative regulation of T cell proliferation, ! reproductive structure development GO:0048608 113 71 4,000 3,785E-05 2,168E-03 ! cell junction organization GO:0034330 86 36 3,000 3,862E-05 2,161E-03 ! plasma membrane organization GO:0007009 24 13 2,000 3,972E-05 2,172E-03 ! serine family amino acid biosynthetic process GO:0009070 17 13 2,000 3,972E-05 2,124E-03 ! regulation of calcium-mediated signaling GO:0050848 25 13 2,000 3,972E-05 2,078E-03 ! cell-matrix adhesion GO:0007160 163 75 4,000 4,933E-05 2,525E-03 ! lymphocyte differentiation GO:0030098 167 75 4,000 4,933E-05 2,473E-03 ! regulation of S phase GO:0033261 23 14 2,000 5,036E-05 2,473E-03 ! T cell differentiation in the thymus GO:0033077 31 14 2,000 5,036E-05 2,423E-03 ! response to gamma radiation GO:0010332 28 14 2,000 5,036E-05 2,376E-03 ! release of cytochrome c from mitochondria GO:0001836 30 14 2,000 5,036E-05 2,33E-03 ! regulation of T cell proliferation GO:0042129 71 41 3,000 6,505E-05 2,953E-03 ! regulation of T cell differentiation GO:0045580 70 41 3,000 6,505E-05 2,898E-03 ! T cell activation GO:0042110 168 81 4,000 7,139E-05 3,123E-03 ! cell-substrate adhesion GO:0031589 171 81 4,000 7,139E-05 3,067E-03 ! cellular response to hormone stimulus GO:0032870 167 82 4,000 7,571E-05 3,196E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 7,688E-05 3,189E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 37 16 2,000 7,688E-05 3,135E-03 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 2,000 9,299E-05 3,729E-03 ! induction of apoptosis by intracellular signals GO:0008629 93 45 3,000 9,415E-05 3,714E-03 ! pigmentation GO:0043473 100 46 3,000 1,027E-04 3,985E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 1,112E-04 4,245E-03 ! sex differentiation GO:0007548 145 90 4,000 1,179E-04 4,431E-03 ! positive regulation of cell cycle GO:0045787 89 48 3,000 1,215E-04 4,496E-03 ! regulation of lymphocyte differentiation GO:0045619 81 48 3,000 1,215E-04 4,428E-03 ! negative regulation of immune system process GO:0002683 95 50 3,000 1,426E-04 5,12E-03 ! response to alkaloid GO:0043279 38 20 2,000 1,541E-04 5,452E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 1,541E-04 5,373E-03 ! negative regulation of T cell activation GO:0050868 40 20 2,000 1,541E-04 5,296E-03 ! negative regulation of translation GO:0017148 29 20 2,000 1,541E-04 5,222E-03 ! leukocyte differentiation GO:0002521 202 96 4,000 1,598E-04 5,341E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 1,791E-04 5,902E-03 ! cell aging GO:0007569 44 21 2,000 1,791E-04 5,822E-03 ! oogenesis GO:0048477 36 21 2,000 1,791E-04 5,745E-03 ! apoptotic nuclear changes GO:0030262 32 22 2,000 2,066E-04 6,539E-03 ! positive regulation of B cell activation GO:0050871 38 22 2,000 2,066E-04 6,454E-03 ! aging GO:0007568 103 55 3,000 2,069E-04 6,381E-03 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 2,000 2,366E-04 7,206E-03 ! leukocyte adhesion GO:0007159 50 23 2,000 2,366E-04 7,116E-03 ! regulation of cell-matrix adhesion GO:0001952 78 23 2,000 2,366E-04 7,028E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 2,366E-04 6,943E-03 ! sex determination GO:0007530 47 23 2,000 2,366E-04 6,859E-03 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 2,000 2,694E-04 7,716E-03 ! lymphocyte proliferation GO:0046651 48 24 2,000 2,694E-04 7,625E-03 ! neuron fate determination GO:0048664 7 5 1,000 2,741E-04 7,668E-03 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 2,741E-04 7,58E-03 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 1,000 2,741E-04 7,494E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 2,741E-04 7,41E-03 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 1,000 2,741E-04 7,328E-03 ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 2,741E-04 7,247E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 2,741E-04 7,168E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 2,741E-04 7,091E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 2,741E-04 7,016E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 2,741E-04 6,942E-03 ! negative regulation of T cell mediated immunity GO:0002710 12 5 1,000 2,741E-04 6,87E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! neural tube patterning GO:0021532 7 5 1,000 2,741E-04 6,799E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 1,000 2,741E-04 6,729E-03 ! B cell homeostasis GO:0001782 13 5 1,000 2,741E-04 6,661E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 1,000 2,741E-04 6,595E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 2,741E-04 6,53E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 2,741E-04 6,466E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 2,741E-04 6,403E-03 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 2,741E-04 6,341E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! stem cell division GO:0017145 11 5 1,000 2,741E-04 6,281E-03 GO:0048103|somatic stem cell division, ! vasculogenesis GO:0001570 46 25 2,000 3,049E-04 6,921E-03 ! negative regulation of DNA replication GO:0008156 42 25 2,000 3,049E-04 6,856E-03 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 3,049E-04 6,793E-03 ! ear development GO:0043583 103 62 3,000 3,288E-04 7,258E-03 ! gonad development GO:0008406 98 62 3,000 3,288E-04 7,192E-03 ! regulation of homeostatic process GO:0032844 134 62 3,000 3,288E-04 7,127E-03 ! leukocyte proliferation GO:0070661 52 26 2,000 3,434E-04 7,376E-03 GO:0032943|mononuclear cell proliferation, ! male gonad development GO:0008584 44 27 2,000 3,848E-04 8,193E-03 ! regulation of chromosome organization GO:0033044 42 27 2,000 3,848E-04 8,121E-03 ! negative regulation of neuron differentiation GO:0045665 42 27 2,000 3,848E-04 8,05E-03 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 3,848E-04 7,981E-03 ! germ cell development GO:0007281 118 65 3,000 3,942E-04 8,106E-03 ! male meiosis GO:0007140 7 6 1,000 4,097E-04 8,354E-03 ! thymic T cell selection GO:0045061 12 6 1,000 4,097E-04 8,284E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 4,097E-04 8,215E-03 ! T cell mediated immunity GO:0002456 16 6 1,000 4,097E-04 8,147E-03 ! male sex determination GO:0030238 15 6 1,000 4,097E-04 8,08E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 4,097E-04 8,015E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of spindle localization GO:0051293 12 6 1,000 4,097E-04 7,95E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 4,097E-04 7,886E-03 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 14 6 1,000 4,097E-04 7,824E-03 ! response to UV-C GO:0010225 11 6 1,000 4,097E-04 7,762E-03 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 4,097E-04 7,702E-03 ! cytoplasmic microtubule organization GO:0031122 14 6 1,000 4,097E-04 7,642E-03 ! negative regulation of B cell activation GO:0050869 13 6 1,000 4,097E-04 7,583E-03 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 4,293E-04 7,885E-03 ! negative regulation of protein kinase activity GO:0006469 130 67 3,000 4,426E-04 8,068E-03 ! negative regulation of cell growth GO:0030308 132 67 3,000 4,426E-04 8,007E-03 ! negative regulation of kinase activity GO:0033673 131 68 3,000 4,684E-04 8,41E-03 ! response to organic cyclic substance GO:0014070 55 29 2,000 4,77E-04 8,501E-03 ! tissue homeostasis GO:0001894 48 29 2,000 4,77E-04 8,438E-03 GO:0048871|multicellular organismal homeostasis, ! negative regulation of cell size GO:0045792 134 69 3,000 4,952E-04 8,696E-03 ! urogenital system development GO:0001655 137 69 3,000 4,952E-04 8,633E-03 ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 5,279E-04 9,138E-03 ! cytokinesis during cell cycle GO:0033205 11 7 1,000 5,716E-04 9,824E-03 ! prostate gland development GO:0030850 13 7 1,000 5,716E-04 9,754E-03 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 5,716E-04 9,685E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 5,716E-04 9,618E-03 ! positive regulation of isotype switching GO:0045830 15 7 1,000 5,716E-04 9,551E-03 GO:0045911|positive regulation of DNA recombination, ! organ growth GO:0035265 15 7 1,000 5,716E-04 9,485E-03 ! positive regulation of mitotic cell cycle GO:0045931 12 7 1,000 5,716E-04 9,42E-03 ! wound healing, spreading of epidermal cells GO:0035313 14 7 1,000 5,716E-04 9,356E-03 ! centrosome duplication GO:0051298 13 7 1,000 5,716E-04 9,293E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 5,716E-04 9,23E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 5,716E-04 9,169E-03 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 1,000 5,716E-04 9,108E-03 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of respiratory burst GO:0060263 11 7 1,000 5,716E-04 9,048E-03 ! peptidyl-threonine modification GO:0018210 25 7 1,000 5,716E-04 8,989E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 5,716E-04 8,931E-03 ! positive regulation of ATPase activity GO:0032781 11 7 1,000 5,716E-04 8,873E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 1,000 5,716E-04 8,816E-03 ! negative regulation of transferase activity GO:0051348 140 72 3,000 5,821E-04 8,921E-03 ! serine family amino acid metabolic process GO:0009069 49 31 2,000 5,822E-04 8,866E-03 ! metanephros development GO:0001656 74 32 2,000 6,4E-04 9,684E-03 ! response to ionizing radiation GO:0010212 65 32 2,000 6,4E-04 9,624E-03 ! hindbrain development GO:0030902 61 32 2,000 6,4E-04 9,564E-03 ! positive regulation of catabolic process GO:0009896 64 32 2,000 6,4E-04 9,505E-03 ! development of primary sexual characteristics GO:0045137 124 76 3,000 7,142E-04 0,01054145 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 7,595E-04 0,01114274 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 7,595E-04 0,01107521 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 7,595E-04 0,01100849 ! pigment granule organization GO:0048753 16 8 1,000 7,595E-04 0,01094257 ! ER overload response GO:0006983 12 8 1,000 7,595E-04 0,01087744 ! regulation of pigmentation during development GO:0048070 24 8 1,000 7,595E-04 0,01081308 ! melanin metabolic process GO:0006582 15 8 1,000 7,595E-04 0,01074947 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 7,595E-04 0,01068661 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 7,595E-04 0,01062448 ! response to UV-B GO:0010224 16 8 1,000 7,595E-04 0,01056306 ! blastocyst growth GO:0001832 19 8 1,000 7,595E-04 0,01050235 ! B cell receptor signaling pathway GO:0050853 16 8 1,000 7,595E-04 0,01044234 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 1,000 7,595E-04 0,01038301 ! negative regulation of DNA replication initiation GO:0032297 9 8 1,000 7,595E-04 0,01032435 GO:0000076|DNA replication checkpoint, ! negative regulation of DNA metabolic process GO:0051053 61 35 2,000 8,348E-04 0,01128355 ! female gonad development GO:0008585 58 35 2,000 8,348E-04 0,01122051 ! response to metal ion GO:0010038 140 80 3,000 8,661E-04 0,01157711 ! negative regulation of cell activation GO:0050866 65 36 2,000 9,072E-04 0,01205863 ! regulation of neuron differentiation GO:0045664 167 81 3,000 9,074E-04 0,01199566 ! regulation of developmental growth GO:0048638 15 9 1,000 9,731E-04 0,01279443 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 9,731E-04 0,0127249 ! regulation of glycolysis GO:0006110 21 9 1,000 9,731E-04 0,01265611 ! middle ear morphogenesis GO:0042474 14 9 1,000 9,731E-04 0,01258807 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 1,000 9,731E-04 0,01252075 ! behavioral fear response GO:0001662 22 9 1,000 9,731E-04 0,01245415 GO:0002209|behavioral defense response, ! regulation of Notch signaling pathway GO:0008593 22 9 1,000 9,731E-04 0,01238826 ! motor axon guidance GO:0008045 16 9 1,000 9,731E-04 0,01232306 ! protein heterooligomerization GO:0051291 16 9 1,000 9,731E-04 0,01225854 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 9,731E-04 0,01219469 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 9,731E-04 0,01213151 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 1,000 9,731E-04 0,01206897 GO:0002820|negative regulation of adaptive immune response, ! regulation of telomere maintenance GO:0032204 14 9 1,000 9,731E-04 0,01200708 ! regulation of protein stability GO:0031647 73 37 2,000 9,834E-04 0,01207163 ! negative regulation of growth GO:0045926 155 84 3,000 1,04E-03 0,01269628 ! positive regulation of DNA metabolic process GO:0051054 72 38 2,000 1,064E-03 0,01292395 ! development of primary female sexual characteristics GO:0046545 67 38 2,000 1,064E-03 0,01285901 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 67 38 2,000 1,064E-03 0,01279471 ! positive regulation of leukocyte proliferation GO:0070665 62 38 2,000 1,064E-03 0,01273106 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to inorganic substance GO:0010035 153 86 3,000 1,135E-03 0,01351666 ! mitochondrion organization GO:0007005 148 86 3,000 1,135E-03 0,01345008 ! mammary gland development GO:0030879 86 39 2,000 1,148E-03 0,0135368 ! development of primary male sexual characteristics GO:0046546 66 39 2,000 1,148E-03 0,01347077 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 1,212E-03 0,01415817 ! COPI coating of Golgi vesicle GO:0048205 19 10 1,000 1,212E-03 0,01408978 GO:0048200|Golgi transport vesicle coating, ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 1,000 1,212E-03 0,01402204 ! B cell proliferation GO:0042100 18 10 1,000 1,212E-03 0,01395495 ! multicellular organism growth GO:0035264 18 10 1,000 1,212E-03 0,01388849 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 1,212E-03 0,01382267 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,212E-03 0,01375747 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell activation GO:0046631 23 10 1,000 1,212E-03 0,01369288 ! regulation of B cell differentiation GO:0045577 19 10 1,000 1,212E-03 0,0136289 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 1,212E-03 0,01356551 ! midbrain development GO:0030901 13 10 1,000 1,212E-03 0,0135027 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 1,212E-03 0,01344048 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 1,212E-03 0,01337882 ! negative regulation of immune effector process GO:0002698 20 10 1,000 1,212E-03 0,01331773 ! cytokinesis GO:0000910 72 40 2,000 1,236E-03 0,01351779 ! regulation of cell adhesion GO:0030155 212 89 3,000 1,289E-03 0,01403253 ! female gamete generation GO:0007292 61 41 2,000 1,328E-03 0,01439793 ! response to reactive oxygen species GO:0000302 67 42 2,000 1,425E-03 0,0153765 ! regulation of intracellular protein transport GO:0033157 80 42 2,000 1,425E-03 0,01530785 ! Golgi vesicle budding GO:0048194 22 11 1,000 1,476E-03 0,01578829 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,476E-03 0,01571843 ! T cell proliferation GO:0042098 26 11 1,000 1,476E-03 0,01564918 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 1,000 1,476E-03 0,01558055 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 1,476E-03 0,01551251 ! adult heart development GO:0007512 14 11 1,000 1,476E-03 0,01544506 ! negative regulation of ossification GO:0030279 26 11 1,000 1,476E-03 0,0153782 ! positive regulation of T cell mediated immunity GO:0002711 24 11 1,000 1,476E-03 0,01531192 ! DNA methylation GO:0006306 19 11 1,000 1,476E-03 0,0152462 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 24 11 1,000 1,476E-03 0,01518105 ! regulation of isotype switching GO:0045191 22 11 1,000 1,476E-03 0,01511645 ! thymus development GO:0048538 27 11 1,000 1,476E-03 0,01505239 ! T cell receptor signaling pathway GO:0050852 23 11 1,000 1,476E-03 0,01498888 ! regulation of embryonic development GO:0045995 27 11 1,000 1,476E-03 0,0149259 ! positive regulation of MAP kinase activity GO:0043406 160 93 3,000 1,516E-03 0,01526586 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 1,526E-03 0,01529976 ! transcription initiation GO:0006352 153 94 3,000 1,577E-03 0,01574779 ! regulation of T cell activation GO:0050863 158 94 3,000 1,577E-03 0,01568272 ! male sex differentiation GO:0046661 76 44 2,000 1,632E-03 0,01615414 ! developmental growth GO:0048589 82 44 2,000 1,632E-03 0,01608794 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 1,766E-03 0,01733909 ! virus-host interaction GO:0019048 29 12 1,000 1,766E-03 0,01726861 ! hippocampus development GO:0021766 26 12 1,000 1,766E-03 0,01719869 ! fear response GO:0042596 26 12 1,000 1,766E-03 0,01712934 ! histone acetylation GO:0016573 26 12 1,000 1,766E-03 0,01706055 ! gland morphogenesis GO:0022612 29 12 1,000 1,766E-03 0,01699231 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,766E-03 0,01692461 ! T cell homeostasis GO:0043029 25 12 1,000 1,766E-03 0,01685745 ! spleen development GO:0048536 22 12 1,000 1,766E-03 0,01679082 ! digestive tract morphogenesis GO:0048546 26 12 1,000 1,766E-03 0,01672471 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! positive regulation of calcium-mediated signaling GO:0050850 24 12 1,000 1,766E-03 0,01665913 ! response to cold GO:0009409 17 12 1,000 1,766E-03 0,01659405 ! regulation of protein localization GO:0032880 176 97 3,000 1,77E-03 0,01657512 ! response to virus GO:0009615 160 98 3,000 1,838E-03 0,01714359 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 2,000 1,856E-03 0,01723834 ! regulation of gene-specific transcription GO:0032583 96 46 2,000 1,856E-03 0,01717204 ! negative regulation of cell migration GO:0030336 115 46 2,000 1,856E-03 0,01710624 ! response to calcium ion GO:0051592 81 47 2,000 1,975E-03 0,01813284 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 2,079E-03 0,01902311 GO:0000725|recombinational repair, ! endocrine pancreas development GO:0031018 22 13 1,000 2,079E-03 0,01895105 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,079E-03 0,01887954 ! response to X-ray GO:0010165 25 13 1,000 2,079E-03 0,01880856 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 2,079E-03 0,01873812 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 2,079E-03 0,0186682 ! cellular component disassembly GO:0022411 86 48 2,000 2,098E-03 0,01876596 ! activation of caspase activity GO:0006919 84 48 2,000 2,098E-03 0,01869646 ! response to temperature stimulus GO:0009266 76 49 2,000 2,226E-03 0,01976604 ! endocrine system development GO:0035270 104 49 2,000 2,226E-03 0,01969337 ! histone modification GO:0016570 91 50 2,000 2,359E-03 0,02079344 ! regulation of gene expression, epigenetic GO:0040029 105 50 2,000 2,359E-03 0,02071756 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 2,418E-03 0,02115174 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 1,000 2,418E-03 0,02107511 ! hair follicle morphogenesis GO:0031069 26 14 1,000 2,418E-03 0,02099902 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 1,000 2,418E-03 0,02092349 ! regulation of mRNA processing GO:0050684 24 14 1,000 2,418E-03 0,02084849 ! actin cytoskeleton reorganization GO:0031532 33 14 1,000 2,418E-03 0,02077403 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 2,418E-03 0,0207001 GO:0060675|ureteric bud morphogenesis, ! response to estrogen stimulus GO:0043627 93 51 2,000 2,497E-03 0,02130578 ! cellular amino acid biosynthetic process GO:0008652 75 51 2,000 2,497E-03 0,02123049 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 2,000 2,497E-03 0,02115573 ! vesicle organization GO:0016050 107 51 2,000 2,497E-03 0,0210815 ! positive regulation of growth GO:0045927 90 52 2,000 2,64E-03 0,02220836 ! covalent chromatin modification GO:0016569 101 52 2,000 2,64E-03 0,02213098 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 2,78E-03 0,02322361 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 2,78E-03 0,02314325 ! heterophilic cell adhesion GO:0007157 39 15 1,000 2,78E-03 0,02306345 ! pituitary gland development GO:0021983 29 15 1,000 2,78E-03 0,02298419 ! vesicle coating GO:0006901 33 15 1,000 2,78E-03 0,02290548 ! intermediate filament cytoskeleton organization GO:0045104 31 15 1,000 2,78E-03 0,0228273 ! regulation of T cell mediated immunity GO:0002709 33 15 1,000 2,78E-03 0,02274966 ! histone deacetylation GO:0016575 20 15 1,000 2,78E-03 0,02267254 ! regulation of ATPase activity GO:0043462 21 15 1,000 2,78E-03 0,02259595 ! lymphocyte homeostasis GO:0002260 30 15 1,000 2,78E-03 0,02251986 ! cell maturation GO:0048469 100 53 2,000 2,788E-03 0,02250616 ! positive regulation of caspase activity GO:0043280 95 55 2,000 3,098E-03 0,0249281 GO:0010952|positive regulation of peptidase activity, ! RNA elongation GO:0006354 79 55 2,000 3,098E-03 0,02484501 ! negative regulation of cell motion GO:0051271 134 55 2,000 3,098E-03 0,02476247 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 3,166E-03 0,02522338 ! G1 phase of mitotic cell cycle GO:0000080 35 16 1,000 3,166E-03 0,02514014 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 3,166E-03 0,02505744 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 3,166E-03 0,02497528 ! auditory receptor cell differentiation GO:0042491 32 16 1,000 3,166E-03 0,02489366 ! intermediate filament-based process GO:0045103 32 16 1,000 3,166E-03 0,02481258 ! negative regulation of immune response GO:0050777 35 16 1,000 3,166E-03 0,02473202 ! axon cargo transport GO:0008088 43 16 1,000 3,166E-03 0,02465198 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 1,000 3,166E-03 0,02457246 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 3,166E-03 0,02449345 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 1,000 3,166E-03 0,02441494 ! positive regulation of cell migration GO:0030335 126 57 2,000 3,429E-03 0,02635547 ! regulation of intracellular transport GO:0032386 101 57 2,000 3,429E-03 0,02627154 ! positive regulation of cell killing GO:0031343 32 17 1,000 3,576E-03 0,02731204 ! metencephalon development GO:0022037 30 17 1,000 3,576E-03 0,02722561 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 3,576E-03 0,02713972 ! limbic system development GO:0021761 36 17 1,000 3,576E-03 0,02705438 ! regulation of viral genome replication GO:0045069 28 17 1,000 3,576E-03 0,02696957 ! regulation of survival gene product expression GO:0045884 33 17 1,000 3,576E-03 0,02688529 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 3,576E-03 0,02680153 ! membrane budding GO:0006900 37 17 1,000 3,576E-03 0,0267183 ! regulation of protein binding GO:0043393 33 17 1,000 3,576E-03 0,02663558 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 1,000 3,576E-03 0,02655337 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of homeostatic process GO:0032845 33 17 1,000 3,576E-03 0,02647167 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 1,000 3,576E-03 0,02639047 ! establishment of organelle localization GO:0051656 109 59 2,000 3,78E-03 0,02781377 ! protein amino acid autophosphorylation GO:0046777 141 60 2,000 3,964E-03 0,02907651 ! kidney development GO:0001822 122 60 2,000 3,964E-03 0,02898814 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 4,009E-03 0,0292281 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 1,000 4,009E-03 0,0291398 ! memory GO:0007613 31 18 1,000 4,009E-03 0,02905203 ! centrosome cycle GO:0007098 25 18 1,000 4,009E-03 0,02896478 ! epidermis morphogenesis GO:0048730 40 18 1,000 4,009E-03 0,02887806 ! regulation of immunoglobulin production GO:0002637 43 18 1,000 4,009E-03 0,02879186 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 4,009E-03 0,02870617 ! lipid phosphorylation GO:0046834 35 19 1,000 4,465E-03 0,03187772 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 4,465E-03 0,03178341 ! forelimb morphogenesis GO:0035136 32 19 1,000 4,465E-03 0,03168965 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 1,000 4,465E-03 0,03159645 ! cellular response to unfolded protein GO:0034620 33 19 1,000 4,465E-03 0,03150379 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 42 19 1,000 4,465E-03 0,03141167 ! neuromuscular junction development GO:0007528 34 19 1,000 4,465E-03 0,03132009 ! cellular pigmentation GO:0033059 36 19 1,000 4,465E-03 0,03122905 ! G1 phase GO:0051318 40 19 1,000 4,465E-03 0,03113853 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 1,000 4,465E-03 0,03104853 ! proximal/distal pattern formation GO:0009954 32 19 1,000 4,465E-03 0,03095906 ! regulation of mitosis GO:0007088 105 63 2,000 4,547E-03 0,03143887 GO:0051783|regulation of nuclear division, ! positive regulation of cell motion GO:0051272 146 64 2,000 4,753E-03 0,03276459 ! protein amino acid deacetylation GO:0006476 29 20 1,000 4,944E-03 0,03398641 ! protein amino acid acetylation GO:0006473 39 20 1,000 4,944E-03 0,03388958 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 4,944E-03 0,0337933 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 4,944E-03 0,03369757 GO:0010675|regulation of cellular carbohydrate metabolic process, ! pancreas development GO:0031016 35 20 1,000 4,944E-03 0,03360238 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 4,944E-03 0,03350772 ! diencephalon development GO:0021536 34 20 1,000 4,944E-03 0,0334136 ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 1,000 4,944E-03 0,03332001 ! inner ear receptor cell differentiation GO:0060113 37 20 1,000 4,944E-03 0,03322693 ! actin filament organization GO:0007015 148 66 2,000 5,18E-03 0,03471601 ! developmental maturation GO:0021700 116 66 2,000 5,18E-03 0,03461958 ! activation of MAPK activity GO:0000187 115 67 2,000 5,402E-03 0,03600369 ! lung development GO:0030324 144 67 2,000 5,402E-03 0,03590423 ! regulation of cell killing GO:0031341 42 21 1,000 5,446E-03 0,03609372 ! ovarian follicle development GO:0001541 35 21 1,000 5,446E-03 0,03599456 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 1,000 5,446E-03 0,03589594 ! DNA modification GO:0006304 34 21 1,000 5,446E-03 0,03579786 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 5,446E-03 0,03570032 ! response to cytokine stimulus GO:0034097 63 21 1,000 5,446E-03 0,03560331 ! gut development GO:0048565 39 21 1,000 5,446E-03 0,03550683 ! cell cycle checkpoint GO:0000075 137 69 2,000 5,863E-03 0,03812631 ! positive regulation of protein catabolic process GO:0045732 38 22 1,000 5,969E-03 0,038713 ! microtubule-based transport GO:0010970 54 22 1,000 5,969E-03 0,03860894 ! regeneration GO:0031099 41 22 1,000 5,969E-03 0,03850543 ! mechanoreceptor differentiation GO:0042490 40 22 1,000 5,969E-03 0,03840247 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 1,000 5,969E-03 0,03830006 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 5,969E-03 0,0381982 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 5,969E-03 0,03809688 ! ureteric bud development GO:0001657 43 22 1,000 5,969E-03 0,0379961 ! renal system process GO:0003014 41 22 1,000 5,969E-03 0,03789584 ! positive regulation of adaptive immune response GO:0002821 39 22 1,000 5,969E-03 0,03779612 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 5,969E-03 0,03769691 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 5,969E-03 0,03759823 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 5,969E-03 0,03750006 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 1,000 5,969E-03 0,03740241 ! respiratory tube development GO:0030323 150 70 2,000 6,102E-03 0,03813515 ! positive regulation of DNA replication GO:0045740 43 23 1,000 6,515E-03 0,04061183 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 6,515E-03 0,04050689 ! regulation of DNA recombination GO:0000018 48 23 1,000 6,515E-03 0,04040249 ! response to ethanol GO:0045471 46 23 1,000 6,515E-03 0,04029862 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 1,000 6,515E-03 0,04019529 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! vesicle targeting GO:0006903 43 23 1,000 6,515E-03 0,04009249 ! regulation of viral reproduction GO:0050792 38 23 1,000 6,515E-03 0,03999022 ! platelet activation GO:0030168 37 23 1,000 6,515E-03 0,03988846 ! regulation of caspase activity GO:0043281 122 72 2,000 6,598E-03 0,04028997 ! respiratory system development GO:0060541 153 72 2,000 6,598E-03 0,04018797 ! learning or memory GO:0007611 147 73 2,000 6,854E-03 0,04164477 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 7,083E-03 0,04292784 ! regulation of cellular catabolic process GO:0031329 52 24 1,000 7,083E-03 0,04281998 ! multicellular organismal response to stress GO:0033555 49 24 1,000 7,083E-03 0,04271266 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 7,083E-03 0,04260588 ! regulation of alpha-beta T cell activation GO:0046634 42 24 1,000 7,083E-03 0,04249963 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 1,000 7,083E-03 0,04239391 GO:0002708|positive regulation of lymphocyte mediated immunity, ! pallium development GO:0021543 49 24 1,000 7,083E-03 0,04228871 ! leukocyte homeostasis GO:0001776 44 24 1,000 7,083E-03 0,04218404 ! protein tetramerization GO:0051262 52 24 1,000 7,083E-03 0,04207988 ! regulation of transcription factor activity GO:0051090 126 74 2,000 7,117E-03 0,04217364 GO:0090046|regulation of transcription regulator activity, ! meiosis GO:0007126 121 74 2,000 7,117E-03 0,04207002 GO:0051327|M phase of meiotic cell cycle, ! regulation of endopeptidase activity GO:0052548 125 74 2,000 7,117E-03 0,04196691 ! eye development GO:0001654 143 74 2,000 7,117E-03 0,0418643 ! organelle localization GO:0051640 136 74 2,000 7,117E-03 0,04176219 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 7,385E-03 0,04323074 ! meiotic cell cycle GO:0051321 122 75 2,000 7,385E-03 0,04312581 ! regulation of catabolic process GO:0009894 161 76 2,000 7,659E-03 0,04461841 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 1,000 7,673E-03 0,04459058 ! myelination GO:0042552 45 25 1,000 7,673E-03 0,04448313 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 7,673E-03 0,0443762 ! negative regulation of cell development GO:0010721 73 25 1,000 7,673E-03 0,04426978 GO:0050768|negative regulation of neurogenesis, ! interaction with host GO:0051701 62 25 1,000 7,673E-03 0,04416388 ! somitogenesis GO:0001756 43 25 1,000 7,673E-03 0,04405847 ! immunoglobulin production GO:0002377 55 25 1,000 7,673E-03 0,04395357 GO:0002440|production of molecular mediator of immune response, ! liver development GO:0001889 53 25 1,000 7,673E-03 0,04384917 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 7,939E-03 0,04526371 ! blood coagulation GO:0007596 146 78 2,000 8,225E-03 0,04678379 GO:0050817|coagulation, ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 2,000 8,225E-03 0,04667345 ! response to steroid hormone stimulus GO:0048545 137 78 2,000 8,225E-03 0,04656363 ! molting cycle process GO:0022404 50 26 1,000 8,283E-03 0,04678411 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! microtubule organizing center organization GO:0031023 39 26 1,000 8,283E-03 0,04667455 GO:0051297|centrosome organization, ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 1,000 8,283E-03 0,04656549 ! cellular response to oxidative stress GO:0034599 39 26 1,000 8,283E-03 0,04645695 ! positive regulation of MAPKKK cascade GO:0043410 47 26 1,000 8,283E-03 0,04634891 ! positive regulation of nuclear division GO:0051785 40 26 1,000 8,283E-03 0,04624137 GO:0045840|positive regulation of mitosis, ! blastocyst development GO:0001824 49 26 1,000 8,283E-03 0,04613433 ! regulation of peptidase activity GO:0052547 134 79 2,000 8,517E-03 0,0473262 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 2,000 8,517E-03 0,04721715 ! regulation of fibroblast proliferation GO:0048145 52 27 1,000 8,915E-03 0,04931119 ! neuron fate commitment GO:0048663 48 27 1,000 8,915E-03 0,0491981 ! protein amino acid acylation GO:0043543 55 27 1,000 8,915E-03 0,04908551 ! fat cell differentiation GO:0045444 50 27 1,000 8,915E-03 0,04897345 ! mitochondrial membrane organization GO:0007006 57 27 1,000 8,915E-03 0,04886189 ! response to toxin GO:0009636 47 27 1,000 8,915E-03 0,04875084 ! base-excision repair GO:0006284 41 27 1,000 8,915E-03 0,04864029 ! response to hypoxia GO:0001666 171 81 2,000 9,119E-03 0,04964079 ! response to drug GO:0042493 143 82 2,000 9,43E-03 0,05121363 ! response to nutrient GO:0007584 125 82 2,000 9,43E-03 0,05109829 ! negative regulation of protein modification process GO:0031400 60 28 1,000 9,568E-03 0,05173246 ! positive regulation of T cell differentiation GO:0045582 42 28 1,000 9,568E-03 0,05161647 ! peptidyl-tyrosine modification GO:0018212 50 28 1,000 9,568E-03 0,05150099 ! response to oxygen levels GO:0070482 176 83 2,000 9,746E-03 0,05234092 ! hemostasis GO:0007599 158 84 2,000 0,0100684 0,05395227 ! regulation of ligase activity GO:0051340 142 84 2,000 0,0100684 0,05383238 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 0,01024156 0,05463679 ! immune response-activating signal transduction GO:0002757 47 29 1,000 0,01024156 0,05451591 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 1,000 0,01024156 0,05439556 ! cell fate determination GO:0001709 60 29 1,000 0,01024156 0,05427575 ! cellular response to extracellular stimulus GO:0031668 48 29 1,000 0,01024156 0,05415646 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 1,000 0,01024156 0,0540377 ! negative regulation of neuron apoptosis GO:0043524 56 29 1,000 0,01024156 0,05391945 ! one-carbon metabolic process GO:0006730 154 85 2,000 0,01039701 0,05461834 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,01039701 0,05449934 GO:0002696|positive regulation of leukocyte activation, ! amine biosynthetic process GO:0009309 138 86 2,000 0,01073179 0,0561319 ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 0,01093539 0,05707277 ! ensheathment of neurons GO:0007272 57 30 1,000 0,01093539 0,05694923 GO:0008366|axon ensheathment, ! response to heat GO:0009408 50 30 1,000 0,01093539 0,05682623 ! regulation of protein transport GO:0051223 154 87 2,000 0,01107275 0,05741605 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 155 88 2,000 0,01141993 0,05908894 ! ovulation cycle process GO:0022602 49 31 1,000 0,0116494 0,0601469 ! positive regulation of T cell proliferation GO:0042102 52 31 1,000 0,0116494 0,0600181 ! iron ion homeostasis GO:0055072 54 31 1,000 0,0116494 0,05988986 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 0,0116494 0,05976216 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 67 31 1,000 0,0116494 0,05963501 ! response to hydrogen peroxide GO:0042542 50 32 1,000 0,01238336 0,06325767 ! spindle organization GO:0007051 46 32 1,000 0,01238336 0,06312365 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,01238336 0,06299019 ! ovulation cycle GO:0042698 51 32 1,000 0,01238336 0,0628573 ! peripheral nervous system development GO:0007422 64 32 1,000 0,01238336 0,06272497 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 1,000 0,01238336 0,0625932 ! response to protein stimulus GO:0051789 149 91 2,000 0,01249891 0,0630448 ! post-embryonic development GO:0009791 69 33 1,000 0,01313704 0,06612494 ! leukocyte chemotaxis GO:0030595 50 33 1,000 0,01313704 0,06598689 GO:0060326|cell chemotaxis, ! negative regulation of protein transport GO:0051224 69 33 1,000 0,01313704 0,06584942 ! establishment of vesicle localization GO:0051650 61 33 1,000 0,01313704 0,06571252 ! regulation of membrane potential GO:0042391 164 93 2,000 0,01324959 0,066138 ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,01391022 0,06929191 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 1,000 0,01391022 0,06914874 ! forebrain development GO:0030900 188 95 2,000 0,01402551 0,06957809 ! regulation of muscle development GO:0048634 70 35 1,000 0,01470267 0,0727873 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,01470267 0,07263784 ! negative regulation of cell adhesion GO:0007162 81 35 1,000 0,01470267 0,07248899 ! telencephalon development GO:0021537 68 35 1,000 0,01470267 0,07234075 ! regulation of microtubule-based process GO:0032886 78 35 1,000 0,01470267 0,07219312 ! vesicle localization GO:0051648 64 35 1,000 0,01470267 0,07204609 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,01551417 0,07586809 ! positive regulation of cell development GO:0010720 80 36 1,000 0,01551417 0,0757142 ! DNA integrity checkpoint GO:0031570 75 36 1,000 0,01551417 0,07556093 ! skeletal muscle tissue development GO:0007519 186 99 2,000 0,01565346 0,07608528 GO:0060538|skeletal muscle organ development, ! meiosis I GO:0007127 65 37 1,000 0,0163445 0,07928402 ! establishment or maintenance of cell polarity GO:0007163 83 37 1,000 0,0163445 0,0791245 ! sister chromatid segregation GO:0000819 58 37 1,000 0,0163445 0,07896561 ! negative regulation of DNA binding GO:0043392 68 37 1,000 0,0163445 0,07880736 ! glycogen metabolic process GO:0005977 61 37 1,000 0,0163445 0,07864975 ! pigment metabolic process GO:0042440 80 37 1,000 0,0163445 0,07849276 ! carbohydrate homeostasis GO:0033500 53 38 1,000 0,01719344 0,08240523 GO:0042593|glucose homeostasis, ! glucan metabolic process GO:0044042 62 38 1,000 0,01719344 0,0822414 GO:0006073|cellular glucan metabolic process, ! ear morphogenesis GO:0042471 60 39 1,000 0,01806078 0,08621872 ! segmentation GO:0035282 67 39 1,000 0,01806078 0,08604799 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 1,000 0,01806078 0,08587793 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,01806078 0,08570855 ! negative regulation of binding GO:0051100 72 40 1,000 0,01894629 0,08973381 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,01894629 0,08955752 ! mesenchymal cell development GO:0014031 87 40 1,000 0,01894629 0,08938191 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! dorsal/ventral pattern formation GO:0009953 68 41 1,000 0,01984977 0,09346094 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,020771 0,09760746 GO:0090047|positive regulation of transcription regulator activity, ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 1,000 0,020771 0,0974172 ! regulation of leukocyte mediated immunity GO:0002703 79 42 1,000 0,020771 0,09722767 ! epithelial cell differentiation GO:0030855 79 43 1,000 0,02170977 0,10142468 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,02170977 0,10122812 ! glucose transport GO:0015758 65 43 1,000 0,02170977 0,10103232 ! neural tube development GO:0021915 77 43 1,000 0,02170977 0,10083727 ! activation of adenylate cyclase activity GO:0007190 91 44 1,000 0,02266588 0,10507534 ! hexose transport GO:0008645 67 44 1,000 0,02266588 0,10487327 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 81 44 1,000 0,02266588 0,10467198 ! biopolymer methylation GO:0043414 84 44 1,000 0,02266588 0,10447146 ! B cell differentiation GO:0030183 107 44 1,000 0,02266588 0,1042717 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 1,000 0,02266588 0,10407271 ! leukocyte migration GO:0050900 68 45 1,000 0,02363911 0,10833467 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,02363911 0,10812871 ! branching morphogenesis of a tube GO:0048754 97 45 1,000 0,02363911 0,10792353 ! cell growth GO:0016049 84 45 1,000 0,02363911 0,10771913 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 1,000 0,02462927 0,11201894 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,02462927 0,11180758 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,02563614 0,11615925 ! positive regulation of cyclase activity GO:0031281 103 47 1,000 0,02563614 0,11594091 ! regulation of adaptive immune response GO:0002819 84 47 1,000 0,02563614 0,11572338 ! methylation GO:0032259 90 47 1,000 0,02563614 0,11550667 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,02612151 0,11747357 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,02612151 0,11725441 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02612151 0,11703606 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,02612151 0,11681852 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02612151 0,11660179 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,02612151 0,11638586 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,02612151 0,11617072 ! polyol transport GO:0015791 12 5 0,000 0,02612151 0,11595639 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,02612151 0,11574284 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02612151 0,11553008 ! response to superoxide GO:0000303 10 5 0,000 0,02612151 0,1153181 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02612151 0,11510689 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,02612151 0,11489646 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,02612151 0,11468679 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02612151 0,11447789 ! female meiosis GO:0007143 7 5 0,000 0,02612151 0,11426975 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02612151 0,11406236 ! cobalt ion transport GO:0006824 11 5 0,000 0,02612151 0,11385573 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,02612151 0,11364984 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,02612151 0,1134447 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,02612151 0,11324029 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02612151 0,11303662 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02612151 0,11283368 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,02612151 0,11263147 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,02612151 0,11242999 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02612151 0,11222922 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,02612151 0,11202917 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,02612151 0,11182983 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02612151 0,11163119 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02612151 0,11143327 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02612151 0,11123604 ! negative chemotaxis GO:0050919 14 5 0,000 0,02612151 0,11103951 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02612151 0,11084367 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02612151 0,11064852 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,02612151 0,11045406 ! behavioral response to pain GO:0048266 9 5 0,000 0,02612151 0,11026028 ! clathrin coat assembly GO:0048268 14 5 0,000 0,02612151 0,11006718 ! Notch receptor processing GO:0007220 8 5 0,000 0,02612151 0,10987476 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02612151 0,10968301 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02612151 0,10949192 ! micturition GO:0060073 9 5 0,000 0,02612151 0,1093015 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02612151 0,10911174 ! copulation GO:0007620 9 5 0,000 0,02612151 0,10892264 ! glial cell fate commitment GO:0021781 13 5 0,000 0,02612151 0,10873419 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,02612151 0,10854639 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02612151 0,10835925 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02612151 0,10817274 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02612151 0,10798688 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,02612151 0,10780165 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02612151 0,10761706 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02612151 0,1074331 ! grooming behavior GO:0007625 6 5 0,000 0,02612151 0,10724976 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02612151 0,10706706 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,02612151 0,10688497 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02612151 0,1067035 ! response to protozoan GO:0001562 10 5 0,000 0,02612151 0,10652265 ! lymph vessel development GO:0001945 10 5 0,000 0,02612151 0,10634241 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,02612151 0,10616277 ! endochondral ossification GO:0001958 16 5 0,000 0,02612151 0,10598375 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02612151 0,10580532 ! parathyroid gland development GO:0060017 13 5 0,000 0,02612151 0,1056275 ! anagen GO:0042640 6 5 0,000 0,02612151 0,10545027 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02612151 0,10527364 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02612151 0,1050976 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,02612151 0,10492214 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,02612151 0,10474727 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,02612151 0,10457298 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,02612151 0,10439927 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,02612151 0,10422614 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,02612151 0,10405358 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02612151 0,10388159 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02612151 0,10371017 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02612151 0,10353931 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,02612151 0,10336902 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,02612151 0,10319928 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02612151 0,1030301 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,02612151 0,10286148 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02612151 0,1026934 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02612151 0,10252588 ! histidine catabolic process GO:0006548 6 5 0,000 0,02612151 0,1023589 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02612151 0,10219246 ! microvillus organization GO:0032528 7 5 0,000 0,02612151 0,10202656 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 10 5 0,000 0,02612151 0,1018612 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02612151 0,10169638 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,02612151 0,10153209 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,02612151 0,10136833 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02612151 0,10120509 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,02612151 0,10104238 ! polyol catabolic process GO:0046174 7 5 0,000 0,02612151 0,1008802 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02612151 0,10071853 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02612151 0,10055738 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02612151 0,10039674 ! muscle cell migration GO:0014812 8 5 0,000 0,02612151 0,10023662 ! mitochondrial fission GO:0000266 8 5 0,000 0,02612151 0,10007701 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,02612151 0,0999179 ! mRNA transcription GO:0009299 9 5 0,000 0,02612151 0,09975931 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,02612151 0,09960121 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,02612151 0,09944361 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,02612151 0,09928651 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02612151 0,09912991 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02612151 0,0989738 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02612151 0,09881818 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02612151 0,09866305 ! response to food GO:0032094 6 5 0,000 0,02612151 0,0985084 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02612151 0,09835424 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02612151 0,09820057 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,02612151 0,09804737 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02612151 0,09789465 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,02612151 0,0977424 ! regulation of phospholipase A2 activity GO:0032429 13 5 0,000 0,02612151 0,09759062 ! forebrain neuron development GO:0021884 13 5 0,000 0,02612151 0,09743932 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02612151 0,09728849 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,02612151 0,09713812 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02612151 0,09698821 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02612151 0,09683877 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,02612151 0,09668979 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02612151 0,09654126 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,02612151 0,09639319 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,02612151 0,09624558 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02612151 0,09609841 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,02612151 0,0959517 ! basic amino acid transport GO:0015802 11 5 0,000 0,02612151 0,09580543 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,02612151 0,09565961 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,02612151 0,09551423 ! depyrimidination GO:0045008 10 5 0,000 0,02612151 0,09536929 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02612151 0,09522479 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02612151 0,09508073 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,02612151 0,0949371 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,02612151 0,09479391 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02612151 0,09465115 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02612151 0,09450882 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02612151 0,09436691 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,02612151 0,09422543 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,02612151 0,09408437 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02612151 0,09394374 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02612151 0,09380353 ! response to arsenic GO:0046685 10 5 0,000 0,02612151 0,09366373 ! mast cell degranulation GO:0043303 7 5 0,000 0,02612151 0,09352435 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,02612151 0,09338538 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,02612151 0,09324683 ! response to cadmium ion GO:0046686 7 5 0,000 0,02612151 0,09310868 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,02612151 0,09297095 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,02612151 0,09283362 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02612151 0,0926967 ! decidualization GO:0046697 11 5 0,000 0,02612151 0,09256018 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,02612151 0,09242406 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,02612151 0,09228834 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02612151 0,09215302 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02612151 0,0920181 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,02612151 0,09188357 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02612151 0,09174943 ! embryonic cleavage GO:0040016 6 5 0,000 0,02612151 0,09161569 ! peroxisome fission GO:0016559 5 5 0,000 0,02612151 0,09148233 ! histone demethylation GO:0016577 10 5 0,000 0,02612151 0,09134936 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,02612151 0,09121678 ! mitotic recombination GO:0006312 9 5 0,000 0,02612151 0,09108458 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02612151 0,09095277 ! metaphase plate congression GO:0051310 7 5 0,000 0,02612151 0,09082133 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02612151 0,09069028 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02612151 0,0905596 ! enteric nervous system development GO:0048484 8 5 0,000 0,02612151 0,0904293 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,02612151 0,09029937 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,02612151 0,09016982 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,02612151 0,09004063 ! muscle cell proliferation GO:0033002 11 5 0,000 0,02612151 0,08991182 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02612151 0,08978337 ! plasminogen activation GO:0031639 5 5 0,000 0,02612151 0,0896553 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,02612151 0,08952758 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02612151 0,08940023 ! metaphase GO:0051323 8 5 0,000 0,02612151 0,08927324 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,02612151 0,08914661 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02612151 0,08902034 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02612151 0,08889443 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02612151 0,08876887 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02612151 0,08864367 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02612151 0,08851882 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,02612151 0,08839432 ! response to redox state GO:0051775 5 5 0,000 0,02612151 0,08827017 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,02612151 0,08814637 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,02612151 0,08802292 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02612151 0,08789981 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,02612151 0,08777704 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02612151 0,08765462 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,02612151 0,08753254 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02612151 0,0874108 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,02612151 0,08728939 ! striatum development GO:0021756 9 5 0,000 0,02612151 0,08716832 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,02612151 0,08704759 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02612151 0,0869272 ! glial cell migration GO:0008347 11 5 0,000 0,02612151 0,08680713 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02612151 0,0866874 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02612151 0,08656799 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02612151 0,08644892 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02612151 0,08633017 ! neuroprotection GO:0043526 6 5 0,000 0,02612151 0,08621175 ! neural plate development GO:0001840 8 5 0,000 0,02612151 0,08609365 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02612151 0,08597587 ! regulation of sensory perception GO:0051931 7 5 0,000 0,02612151 0,08585842 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02612151 0,08574129 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,02612151 0,08562447 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,02612151 0,08550798 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02612151 0,0853918 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02612151 0,08527593 ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02612151 0,08516038 ! spindle assembly GO:0051225 6 5 0,000 0,02612151 0,08504515 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,02612151 0,08493022 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02612151 0,0848156 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02612151 0,0847013 ! drug metabolic process GO:0017144 6 5 0,000 0,02612151 0,0845873 ! organ regeneration GO:0031100 7 5 0,000 0,02612151 0,08447361 ! carnitine metabolic process GO:0009437 7 5 0,000 0,02612151 0,08436022 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,02612151 0,08424713 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02612151 0,08413435 ! mitochondrial transport GO:0006839 82 48 1,000 0,02665954 0,08575247 ! Notch signaling pathway GO:0007219 96 48 1,000 0,02665954 0,08563798 ! positive regulation of lyase activity GO:0051349 104 48 1,000 0,02665954 0,08552379 ! regulation of action potential GO:0001508 95 49 1,000 0,02769925 0,08874086 ! DNA-dependent DNA replication GO:0006261 74 49 1,000 0,02769925 0,08862286 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,02769925 0,08850516 ! regulation of ossification GO:0030278 117 50 1,000 0,02875508 0,09175691 ! inner ear development GO:0048839 79 50 1,000 0,02875508 0,09163538 ! positive regulation of binding GO:0051099 78 51 1,000 0,02982683 0,09492506 ! epithelial tube morphogenesis GO:0060562 98 51 1,000 0,02982683 0,09479966 ! regulation of angiogenesis GO:0045765 114 52 1,000 0,0309143 0,0981264 ! morphogenesis of a branching structure GO:0001763 111 52 1,000 0,0309143 0,09799712 ! synapse organization GO:0050808 85 52 1,000 0,0309143 0,09786818 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03126387 0,09884478 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03126387 0,09871506 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,03126387 0,09858568 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03126387 0,09845664 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03126387 0,09832794 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,03126387 0,09819958 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,03126387 0,09807155 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03126387 0,09794385 ! sleep GO:0030431 13 6 0,000 0,03126387 0,09781648 ! response to oxygen radical GO:0000305 11 6 0,000 0,03126387 0,09768945 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,03126387 0,09756274 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,03126387 0,09743637 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,03126387 0,09731032 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,03126387 0,09718459 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03126387 0,09705919 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03126387 0,09693412 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,03126387 0,09680936 ! forebrain regionalization GO:0021871 8 6 0,000 0,03126387 0,09668493 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03126387 0,09656082 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03126387 0,09643702 ! response to zinc ion GO:0010043 9 6 0,000 0,03126387 0,09631354 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03126387 0,09619038 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,03126387 0,09606753 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,03126387 0,09594499 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03126387 0,09582277 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03126387 0,09570086 ! malate metabolic process GO:0006108 11 6 0,000 0,03126387 0,09557926 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,03126387 0,09545796 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,03126387 0,09533698 ! protein refolding GO:0042026 15 6 0,000 0,03126387 0,0952163 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03126387 0,09509592 ! opsonization GO:0008228 8 6 0,000 0,03126387 0,09497585 ! mating behavior GO:0007617 7 6 0,000 0,03126387 0,09485608 ! neuron remodeling GO:0016322 15 6 0,000 0,03126387 0,09473662 ! erythrocyte maturation GO:0043249 7 6 0,000 0,03126387 0,09461745 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,03126387 0,09449859 ! equilibrioception GO:0050957 14 6 0,000 0,03126387 0,09438002 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,03126387 0,09426175 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,03126387 0,09414377 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03126387 0,09402609 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,03126387 0,09390871 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03126387 0,09379161 ! response to interferon-gamma GO:0034341 15 6 0,000 0,03126387 0,09367481 ! toxin metabolic process GO:0009404 11 6 0,000 0,03126387 0,0935583 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03126387 0,09344208 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03126387 0,09332615 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,03126387 0,0932105 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,03126387 0,09309514 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,03126387 0,09298007 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,03126387 0,09286528 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03126387 0,09275077 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,03126387 0,09263655 ! protein lipoylation GO:0009249 10 6 0,000 0,03126387 0,0925226 ! cysteine metabolic process GO:0006534 10 6 0,000 0,03126387 0,09240894 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03126387 0,09229555 ! glutamate catabolic process GO:0006538 10 6 0,000 0,03126387 0,09218245 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,03126387 0,09206961 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03126387 0,09195706 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,03126387 0,09184478 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,03126387 0,09173277 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03126387 0,09162104 ! hyperosmotic response GO:0006972 9 6 0,000 0,03126387 0,09150958 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,03126387 0,09139839 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,03126387 0,09128747 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03126387 0,09117682 ! urea metabolic process GO:0019627 7 6 0,000 0,03126387 0,09106643 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03126387 0,09095632 ! neutrophil activation GO:0042119 8 6 0,000 0,03126387 0,09084647 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03126387 0,09073688 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,03126387 0,09062756 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03126387 0,0905185 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03126387 0,09040971 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03126387 0,09030117 ! neuron apoptosis GO:0051402 9 6 0,000 0,03126387 0,0901929 ! nucleoside salvage GO:0043174 9 6 0,000 0,03126387 0,09008488 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,03126387 0,08997712 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03126387 0,08986962 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03126387 0,08976238 GO:0010543|regulation of platelet activation, ! carnitine transport GO:0015879 10 6 0,000 0,03126387 0,08965539 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,03126387 0,08954866 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03126387 0,08944218 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,03126387 0,08933596 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,03126387 0,08922998 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,03126387 0,08912426 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,03126387 0,08901879 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,03126387 0,08891356 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,03126387 0,08880859 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,03126387 0,08870386 ! monocyte differentiation GO:0030224 12 6 0,000 0,03126387 0,08859938 ! astrocyte development GO:0014002 15 6 0,000 0,03126387 0,08849515 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,03126387 0,08839116 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03126387 0,08828741 ! interaction with symbiont GO:0051702 13 6 0,000 0,03126387 0,08818391 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03126387 0,08808065 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03126387 0,08797763 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,03126387 0,08787485 ! response to copper ion GO:0046688 10 6 0,000 0,03126387 0,08777232 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,03126387 0,08767002 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,03126387 0,08756796 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03126387 0,08746613 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03126387 0,08736455 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03126387 0,0872632 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,03126387 0,08716208 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03126387 0,0870612 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,03126387 0,08696055 ! hair follicle maturation GO:0048820 7 6 0,000 0,03126387 0,08686013 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03126387 0,08675995 ! Schwann cell development GO:0014044 15 6 0,000 0,03126387 0,08665999 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,03126387 0,08656027 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03126387 0,08646078 ! subpallium development GO:0021544 10 6 0,000 0,03126387 0,08636151 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,03126387 0,08626247 ! histone ubiquitination GO:0016574 8 6 0,000 0,03126387 0,08616366 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,03126387 0,08606507 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03126387 0,08596671 ! G2 phase GO:0051319 16 6 0,000 0,03126387 0,08586858 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,03126387 0,08577067 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03126387 0,08567298 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,03126387 0,08557551 ! membrane to membrane docking GO:0022614 14 6 0,000 0,03126387 0,08547827 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03126387 0,08538124 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,03126387 0,08528444 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03126387 0,08518785 ! receptor internalization GO:0031623 10 6 0,000 0,03126387 0,08509149 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,03126387 0,08499534 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,03126387 0,08489941 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03126387 0,08480369 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,03126387 0,08470819 ! protein deubiquitination GO:0016579 14 6 0,000 0,03126387 0,08461291 ! negative regulation of neuroblast proliferation GO:0007406 21 6 0,000 0,03126387 0,08451784 ! protein destabilization GO:0031648 9 6 0,000 0,03126387 0,08442298 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03126387 0,08432834 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,03126387 0,0842339 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03126387 0,08413968 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,03126387 0,08404567 ! progesterone metabolic process GO:0042448 10 6 0,000 0,03126387 0,08395187 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,03126387 0,08385828 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,03126387 0,08376489 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,03126387 0,08367172 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,03126387 0,08357875 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03126387 0,08348599 ! determination of adult lifespan GO:0008340 15 6 0,000 0,03126387 0,08339343 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,03126387 0,08330108 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,03126387 0,08320893 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03126387 0,08311699 ! catecholamine transport GO:0051937 9 6 0,000 0,03126387 0,08302525 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,03126387 0,08293371 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03126387 0,08284237 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03126387 0,08275124 ! maternal placenta development GO:0001893 12 6 0,000 0,03126387 0,0826603 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,03126387 0,08256957 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03126387 0,08247903 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,03126387 0,08238869 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03126387 0,08229855 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,03126387 0,08220861 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,03126387 0,08211886 ! regulation of neuron apoptosis GO:0043523 100 53 1,000 0,03201731 0,08400617 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 0,03426917 0,08981657 ! regulation of protein catabolic process GO:0042176 116 55 1,000 0,03426917 0,08971884 ! heart morphogenesis GO:0003007 97 55 1,000 0,03426917 0,08962132 ! regulation of multicellular organism growth GO:0040014 85 55 1,000 0,03426917 0,08952401 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,03541763 0,09242388 ! positive regulation of organelle organization GO:0010638 100 56 1,000 0,03541763 0,09232374 ! tRNA transcription GO:0009304 14 7 0,000 0,03637925 0,09472778 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,03637925 0,09462537 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,03637925 0,09452318 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03637925 0,09442122 ! regulation of helicase activity GO:0051095 15 7 0,000 0,03637925 0,09431947 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,03637925 0,09421794 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03637925 0,09411663 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,03637925 0,09401554 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03637925 0,09391466 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,03637925 0,093814 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03637925 0,09371356 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03637925 0,09361333 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,03637925 0,09351332 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03637925 0,09341352 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,03637925 0,09331393 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,03637925 0,09321455 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,03637925 0,09311539 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,03637925 0,09301644 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03637925 0,09291769 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,03637925 0,09281916 ! glycolipid transport GO:0046836 10 7 0,000 0,03637925 0,09272083 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03637925 0,09262272 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,03637925 0,09252481 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03637925 0,0924271 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,03637925 0,09232961 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03637925 0,09223231 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,03637925 0,09213523 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,03637925 0,09203835 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,03637925 0,09194167 ! mRNA stabilization GO:0048255 18 7 0,000 0,03637925 0,09184519 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 14 7 0,000 0,03637925 0,09174892 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,03637925 0,09165284 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,03637925 0,09155697 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,03637925 0,0914613 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03637925 0,09136583 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03637925 0,09127056 ! lipoprotein transport GO:0042953 14 7 0,000 0,03637925 0,09117549 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03637925 0,09108061 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03637925 0,09098593 ! rhythmic behavior GO:0007622 15 7 0,000 0,03637925 0,09089145 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,03637925 0,09079716 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,03637925 0,09070307 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,03637925 0,09060918 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03637925 0,09051548 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,03637925 0,09042197 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03637925 0,09032865 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,03637925 0,09023553 ! mechanosensory behavior GO:0007638 14 7 0,000 0,03637925 0,0901426 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,03637925 0,09004986 ! positive regulation of heart rate GO:0010460 10 7 0,000 0,03637925 0,08995731 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03637925 0,08986496 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03637925 0,08977279 ! spinal cord patterning GO:0021511 13 7 0,000 0,03637925 0,08968081 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,03637925 0,08958901 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03637925 0,08949741 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,03637925 0,08940599 ! adrenal gland development GO:0030325 17 7 0,000 0,03637925 0,08931476 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,03637925 0,08922372 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,03637925 0,08913286 ! ovulation GO:0030728 9 7 0,000 0,03637925 0,08904218 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,03637925 0,08895169 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,03637925 0,08886139 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,03637925 0,08877126 ! microtubule nucleation GO:0007020 20 7 0,000 0,03637925 0,08868132 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03637925 0,08859157 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03637925 0,08850199 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,03637925 0,08841259 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,03637925 0,08832338 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,03637925 0,08823434 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03637925 0,08814548 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03637925 0,08805681 ! galactose metabolic process GO:0006012 13 7 0,000 0,03637925 0,08796831 ! vesicle fusion GO:0006906 17 7 0,000 0,03637925 0,08787999 ! response to dietary excess GO:0002021 8 7 0,000 0,03637925 0,08779184 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03637925 0,08770387 ! intracellular pH reduction GO:0051452 11 7 0,000 0,03637925 0,08761608 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03637925 0,08752847 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,03637925 0,08744103 ! purine salvage GO:0043101 10 7 0,000 0,03637925 0,08735376 ! nucleoside transport GO:0015858 8 7 0,000 0,03637925 0,08726667 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,03637925 0,08717975 ! parturition GO:0007567 14 7 0,000 0,03637925 0,087093 ! rRNA modification GO:0000154 14 7 0,000 0,03637925 0,08700643 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,03637925 0,08692003 ! spindle checkpoint GO:0031577 15 7 0,000 0,03637925 0,0868338 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,03637925 0,08674774 ! macrophage differentiation GO:0030225 11 7 0,000 0,03637925 0,08666185 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03637925 0,08657613 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03637925 0,08649058 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,03637925 0,0864052 ! G1 DNA damage checkpoint GO:0031571 21 7 0,000 0,03637925 0,08631999 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03637925 0,08623494 ! fibrinolysis GO:0042730 10 7 0,000 0,03637925 0,08615007 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 0,000 0,03637925 0,08606536 ! eating behavior GO:0042755 7 7 0,000 0,03637925 0,08598081 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03637925 0,08589643 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,03637925 0,08581222 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,03637925 0,08572817 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03637925 0,08564429 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,03637925 0,08556057 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03637925 0,08547702 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,03637925 0,08539363 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,03637925 0,0853104 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,03637925 0,08522733 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,03637925 0,08514442 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03637925 0,08506168 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,03637925 0,08497909 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03637925 0,08489667 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03637925 0,08481441 ! regulation of meiosis GO:0040020 12 7 0,000 0,03637925 0,0847323 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,03637925 0,08465035 ! regulation of lipid transport GO:0032368 14 7 0,000 0,03637925 0,08456857 ! oxygen homeostasis GO:0032364 12 7 0,000 0,03637925 0,08448694 ! transcription termination GO:0006353 13 7 0,000 0,03637925 0,08440546 ! response to tumor cell GO:0002347 13 7 0,000 0,03637925 0,08432415 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03637925 0,08424299 ! anaphase GO:0051322 17 7 0,000 0,03637925 0,08416199 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,03637925 0,08408114 ! axonal fasciculation GO:0007413 18 7 0,000 0,03637925 0,08400045 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,03637925 0,08391991 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,03637925 0,08383953 ! diuresis GO:0030146 12 7 0,000 0,03637925 0,0837593 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03637925 0,08367922 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03637925 0,0835993 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03637925 0,08351953 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,03637925 0,08343991 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,03637925 0,08336044 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03637925 0,08328113 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03637925 0,08320196 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03637925 0,08312295 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03637925 0,08304409 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,03637925 0,08296537 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03637925 0,08288681 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,03637925 0,08280839 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,03637925 0,08273012 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03637925 0,082652 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,03637925 0,08257402 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,03637925 0,0824962 ! adult feeding behavior GO:0008343 9 7 0,000 0,03637925 0,08241852 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,03637925 0,08234098 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,03637925 0,0822636 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03637925 0,08218635 ! muscle adaptation GO:0043500 14 7 0,000 0,03637925 0,08210926 ! embryonic heart tube development GO:0035050 10 7 0,000 0,03637925 0,0820323 ! retina homeostasis GO:0001895 12 7 0,000 0,03637925 0,08195549 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,03637925 0,08187883 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,03637925 0,08180231 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,03637925 0,08172593 ! protein prenylation GO:0018342 18 7 0,000 0,03637925 0,08164969 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,03637925 0,08157359 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,03637925 0,08149764 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03637925 0,08142183 ! regulation of bone remodeling GO:0046850 137 57 1,000 0,03658087 0,08179699 ! muscle fiber development GO:0048747 112 57 1,000 0,03658087 0,08172104 ! lipid modification GO:0030258 97 57 1,000 0,03658087 0,08164523 ! regulation of tissue remodeling GO:0034103 140 58 1,000 0,03775869 0,08419593 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,03895092 0,08677399 ! DNA damage response, signal transduction GO:0042770 128 60 1,000 0,04015737 0,08937893 ! camera-type eye development GO:0043010 116 60 1,000 0,04015737 0,08929633 ! negative regulation of response to stimulus GO:0048585 100 60 1,000 0,04015737 0,08921388 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,04146778 0,09204011 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,04146778 0,09195528 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,04146778 0,0918706 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,04146778 0,09178609 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04146778 0,09170172 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04146778 0,09161752 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,04146778 0,09153346 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,04146778 0,09144956 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,04146778 0,09136582 ! meiotic prophase I GO:0007128 13 8 0,000 0,04146778 0,09128223 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04146778 0,09119879 ! oligopeptide transport GO:0006857 15 8 0,000 0,04146778 0,0911155 ! UTP metabolic process GO:0046051 8 8 0,000 0,04146778 0,09103237 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,04146778 0,09094938 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,04146778 0,09086655 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,04146778 0,09078387 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04146778 0,09070134 ! succinate metabolic process GO:0006105 14 8 0,000 0,04146778 0,09061896 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04146778 0,09053673 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,04146778 0,09045465 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04146778 0,09037271 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,04146778 0,09029093 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04146778 0,09020929 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04146778 0,0901278 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,04146778 0,09004646 ! reflex GO:0060004 16 8 0,000 0,04146778 0,08996526 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,04146778 0,08988421 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,04146778 0,08980331 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04146778 0,08972255 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,04146778 0,08964194 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,04146778 0,08956147 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,04146778 0,08948114 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04146778 0,08940096 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04146778 0,08932093 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,04146778 0,08924103 ! astrocyte differentiation GO:0048708 18 8 0,000 0,04146778 0,08916128 ! histidine metabolic process GO:0006547 16 8 0,000 0,04146778 0,08908167 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04146778 0,08900221 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,04146778 0,08892288 ! glycine catabolic process GO:0006546 13 8 0,000 0,04146778 0,0888437 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,04146778 0,08876466 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,04146778 0,08868576 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,04146778 0,08860699 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,04146778 0,08852837 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04146778 0,08844989 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04146778 0,08837155 ! macrophage activation GO:0042116 12 8 0,000 0,04146778 0,08829334 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04146778 0,08821527 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,04146778 0,08813734 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,04146778 0,08805955 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,04146778 0,0879819 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04146778 0,08790438 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,04146778 0,087827 ! osteoblast development GO:0002076 16 8 0,000 0,04146778 0,08774976 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,04146778 0,08767265 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,04146778 0,08759568 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,04146778 0,08751884 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,04146778 0,08744213 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,04146778 0,08736556 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04146778 0,08728913 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,04146778 0,08721283 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04146778 0,08713666 ! intermediate filament organization GO:0045109 12 8 0,000 0,04146778 0,08706062 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,04146778 0,08698472 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,04146778 0,08690895 ! cellular extravasation GO:0045123 12 8 0,000 0,04146778 0,08683331 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,04146778 0,0867578 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,04146778 0,08668243 ! response to antibiotic GO:0046677 11 8 0,000 0,04146778 0,08660718 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,04146778 0,08653207 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,04146778 0,08645708 ! DNA topological change GO:0006265 12 8 0,000 0,04146778 0,08638223 ! response to tropane GO:0014073 15 8 0,000 0,04146778 0,0863075 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,04146778 0,08623291 ! melanosome transport GO:0032402 13 8 0,000 0,04146778 0,08615844 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,04146778 0,0860841 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04146778 0,08600989 ! mast cell activation GO:0045576 14 8 0,000 0,04146778 0,08593581 ! multicellular organismal aging GO:0010259 18 8 0,000 0,04146778 0,08586185 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,04146778 0,08578803 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,04146778 0,08571433 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,04146778 0,08564075 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04146778 0,0855673 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04146778 0,08549398 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,04146778 0,08542078 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04146778 0,08534771 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04146778 0,08527476 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,04146778 0,08520194 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,04146778 0,08512924 ! intracellular lipid transport GO:0032365 13 8 0,000 0,04146778 0,08505667 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04146778 0,08498422 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04146778 0,08491189 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,04146778 0,08483969 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,04146778 0,08476761 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04146778 0,08469565 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,04146778 0,08462381 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,04146778 0,0845521 ! hormone catabolic process GO:0042447 17 8 0,000 0,04146778 0,0844805 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04146778 0,08440903 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,04146778 0,08433768 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,04146778 0,08426645 ! ATP catabolic process GO:0006200 11 8 0,000 0,04146778 0,08419534 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04146778 0,08412435 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04146778 0,08405347 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,04146778 0,08398272 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04146778 0,08391209 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04146778 0,08384158 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,04146778 0,08377118 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,04146778 0,0837009 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,04146778 0,08363074 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,04146778 0,0835607 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,04146778 0,08349077 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04146778 0,08342097 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04146778 0,08335127 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04146778 0,0832817 ! NAD biosynthetic process GO:0009435 13 8 0,000 0,04146778 0,08321224 ! viral reproductive process GO:0022415 126 62 1,000 0,04261221 0,08543747 ! detection of external stimulus GO:0009581 91 63 1,000 0,04386024 0,08786655 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 1,000 0,04512177 0,09031862 ! lymphocyte mediated immunity GO:0002449 114 64 1,000 0,04512177 0,09024355 ! multicellular organism reproduction GO:0032504 111 64 1,000 0,04512177 0,09016859 GO:0048609|reproductive process in a multicellular organism, ! regulation of cytokine biosynthetic process GO:0042035 95 65 1,000 0,04639664 0,09263926 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,04639664 0,09256245 GO:0035113|embryonic appendage morphogenesis, ! axon extension GO:0048675 15 9 0,000 0,04652961 0,09275082 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,04652961 0,09267404 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,04652961 0,09259738 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,04652961 0,09252086 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04652961 0,09244446 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,04652961 0,09236818 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,04652961 0,09229203 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,04652961 0,09221601 ! phosphate transport GO:0006817 19 9 0,000 0,04652961 0,09214011 ! reproductive behavior GO:0019098 19 9 0,000 0,04652961 0,09206434 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04652961 0,09198869 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,04652961 0,09191317 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04652961 0,09183777 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,04652961 0,09176249 ! GTP metabolic process GO:0046039 9 9 0,000 0,04652961 0,09168734 ! RNA methylation GO:0001510 15 9 0,000 0,04652961 0,0916123 ! elastic fiber assembly GO:0048251 15 9 0,000 0,04652961 0,0915374 ! induction of positive chemotaxis GO:0050930 15 9 0,000 0,04652961 0,09146261 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,04652961 0,09138795 ! artery development GO:0060840 24 9 0,000 0,04652961 0,09131341 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,04652961 0,09123899 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,04652961 0,09116469 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,04652961 0,09109051 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,04652961 0,09101645 ! chemosensory behavior GO:0007635 20 9 0,000 0,04652961 0,09094252 ! microtubule bundle formation GO:0001578 21 9 0,000 0,04652961 0,0908687 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,04652961 0,090795 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04652961 0,09072142 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,04652961 0,09064796 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,04652961 0,09057462 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,04652961 0,0905014 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04652961 0,0904283 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04652961 0,09035532 ! protein targeting to ER GO:0045047 22 9 0,000 0,04652961 0,09028245 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,04652961 0,0902097 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,04652961 0,09013707 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,04652961 0,09006455 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04652961 0,08999215 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,04652961 0,08991987 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04652961 0,0898477 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04652961 0,08977565 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04652961 0,08970371 ! mannose metabolic process GO:0006013 13 9 0,000 0,04652961 0,08963189 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,04652961 0,08956019 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,04652961 0,0894886 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,04652961 0,08941712 ! receptor clustering GO:0043113 18 9 0,000 0,04652961 0,08934576 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,04652961 0,08927451 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04652961 0,08920338 ! ruffle organization GO:0031529 15 9 0,000 0,04652961 0,08913235 ! retinol metabolic process GO:0042572 18 9 0,000 0,04652961 0,08906144 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,04652961 0,08899065 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,04652961 0,08891997 GO:0007351|tripartite regional subdivision, ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,04652961 0,08884939 GO:0030204|chondroitin sulfate metabolic process, ! oligodendrocyte development GO:0014003 10 9 0,000 0,04652961 0,08877893 ! segment specification GO:0007379 13 9 0,000 0,04652961 0,08870859 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04652961 0,08863835 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,04652961 0,08856822 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04652961 0,08849821 ! response to amine stimulus GO:0014075 13 9 0,000 0,04652961 0,08842831 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04652961 0,08835851 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,04652961 0,08828883 ! erythrocyte development GO:0048821 15 9 0,000 0,04652961 0,08821926 ! gas homeostasis GO:0033483 16 9 0,000 0,04652961 0,08814979 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04652961 0,08808044 ! renal water homeostasis GO:0003091 14 9 0,000 0,04652961 0,08801119 ! postreplication repair GO:0006301 22 9 0,000 0,04652961 0,08794206 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,04652961 0,08787303 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,04652961 0,08780411 ! icosanoid secretion GO:0032309 15 9 0,000 0,04652961 0,08773529 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,04652961 0,08766659 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04652961 0,08759799 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,04652961 0,0875295 ! regulation of cell division GO:0051302 15 9 0,000 0,04652961 0,08746112 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,04652961 0,08739285 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,04652961 0,08732468 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04652961 0,08725661 ! sterol catabolic process GO:0016127 11 9 0,000 0,04652961 0,08718866 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04652961 0,08712081 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,04652961 0,08705306 ! S phase GO:0051320 9 9 0,000 0,04652961 0,08698542 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,04652961 0,08691789 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,04652961 0,08685045 ! musculoskeletal movement GO:0050881 14 9 0,000 0,04652961 0,08678313 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,04652961 0,08671591 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,04652961 0,08664879 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04652961 0,08658178 ! purine base metabolic process GO:0006144 21 9 0,000 0,04652961 0,08651487 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,04652961 0,08644806 ! pigment granule transport GO:0051904 17 9 0,000 0,04652961 0,08638136 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,04652961 0,08631475 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,04652961 0,08624826 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04652961 0,08618186 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04652961 0,08611557 ! mitochondrion localization GO:0051646 15 9 0,000 0,04652961 0,08604937 ! secondary metabolic process GO:0019748 116 66 1,000 0,04768466 0,08811773 ! chromosome segregation GO:0007059 113 67 1,000 0,04898566 0,09045242 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,04898566 0,09038305 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 1,000 0,04898566 0,09031379 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,04898566 0,09024464 ! adaptive immune response GO:0002250 119 67 1,000 0,04898566 0,09017559 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 1,000 0,04898566 0,09010665 ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,05029948 0,09245267 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 134 68 1,000 0,05029948 0,09238209 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 1,000 0,05029948 0,09231163 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,05156487 0,0945618 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05156487 0,09448978 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,05156487 0,09441787 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05156487 0,09434607 ! synapsis GO:0007129 13 10 0,000 0,05156487 0,09427438 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,05156487 0,0942028 ! N-glycan processing GO:0006491 20 10 0,000 0,05156487 0,09413133 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,05156487 0,09405996 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,05156487 0,0939887 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,05156487 0,09391755 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,05156487 0,09384651 ! smoothened signaling pathway GO:0007224 16 10 0,000 0,05156487 0,09377558 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,05156487 0,09370475 ! androgen metabolic process GO:0008209 17 10 0,000 0,05156487 0,09363403 ! phospholipid efflux GO:0033700 16 10 0,000 0,05156487 0,09356341 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05156487 0,09349291 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,05156487 0,0934225 ! lung alveolus development GO:0048286 26 10 0,000 0,05156487 0,09335221 ! pathogenesis GO:0009405 13 10 0,000 0,05156487 0,09328202 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05156487 0,09321194 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,05156487 0,09314196 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,05156487 0,09307208 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,05156487 0,09300231 ! endoderm development GO:0007492 16 10 0,000 0,05156487 0,09293265 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,05156487 0,09286309 ! arginine catabolic process GO:0006527 13 10 0,000 0,05156487 0,09279363 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05156487 0,09272428 ! proline metabolic process GO:0006560 13 10 0,000 0,05156487 0,09265503 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05156487 0,09258589 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,05156487 0,09251684 ! V(D)J recombination GO:0033151 28 10 0,000 0,05156487 0,0924479 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05156487 0,09237907 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,05156487 0,09231033 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,05156487 0,0922417 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,05156487 0,09217317 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,05156487 0,09210474 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,05156487 0,09203641 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,05156487 0,09196819 ! epithelial cell development GO:0002064 20 10 0,000 0,05156487 0,09190006 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,05156487 0,09183204 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05156487 0,09176412 ! macroautophagy GO:0016236 17 10 0,000 0,05156487 0,09169629 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,05156487 0,09162857 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,05156487 0,09156095 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,05156487 0,09149343 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,05156487 0,091426 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05156487 0,09135868 ! regulation of bone resorption GO:0045124 25 10 0,000 0,05156487 0,09129145 ! brain morphogenesis GO:0048854 23 10 0,000 0,05156487 0,09122433 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,05156487 0,0911573 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,05156487 0,09109037 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 0,000 0,05156487 0,09102354 ! blastoderm segmentation GO:0007350 18 10 0,000 0,05156487 0,09095681 ! response to dsRNA GO:0043331 20 10 0,000 0,05156487 0,09089017 ! DNA ligation GO:0006266 19 10 0,000 0,05156487 0,09082364 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05156487 0,0907572 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05156487 0,09069085 ! melanosome localization GO:0032400 16 10 0,000 0,05156487 0,09062461 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,05156487 0,09055846 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,05156487 0,0904924 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05156487 0,09042645 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,05156487 0,09036059 ! mRNA cleavage GO:0006379 17 10 0,000 0,05156487 0,09029482 ! protein sumoylation GO:0016925 15 10 0,000 0,05156487 0,09022915 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05156487 0,09016358 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05156487 0,0900981 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,05156487 0,09003272 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,05156487 0,08996743 ! salivary gland development GO:0007431 27 10 0,000 0,05156487 0,08990224 ! prophase GO:0051324 15 10 0,000 0,05156487 0,08983714 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05156487 0,08977213 ! apical protein localization GO:0045176 15 10 0,000 0,05156487 0,08970722 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,05156487 0,0896424 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,05156487 0,08957768 ! positive regulation of leukocyte migration GO:0002687 25 10 0,000 0,05156487 0,08951305 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05156487 0,08944851 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,05156487 0,08938407 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,05156487 0,08931972 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,05156487 0,08925546 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05156487 0,08919129 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05156487 0,08912722 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,05156487 0,08906324 ! detection of calcium ion GO:0005513 23 10 0,000 0,05156487 0,08899934 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05156487 0,08893555 ! blastocyst formation GO:0001825 17 10 0,000 0,05156487 0,08887184 ! cerebellar cortex development GO:0021695 15 10 0,000 0,05156487 0,08880822 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,05156487 0,0887447 ! activation of innate immune response GO:0002218 12 10 0,000 0,05156487 0,08868126 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,05156487 0,08861792 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,05156487 0,08855467 ! establishment of cell polarity GO:0030010 16 10 0,000 0,05156487 0,0884915 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,05156487 0,08842843 ! localization within membrane GO:0051668 20 10 0,000 0,05156487 0,08836545 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 1,000 0,05162593 0,08840712 ! antigen processing and presentation GO:0019882 104 69 1,000 0,05162593 0,08834424 ! appendage morphogenesis GO:0035107 135 70 1,000 0,05296487 0,09057105 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 136 71 1,000 0,0543161 0,09281573 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 1,000 0,0543161 0,09274986 ! B cell activation GO:0042113 160 71 1,000 0,0543161 0,09268408 ! regulation of MAPKKK cascade GO:0043408 142 71 1,000 0,0543161 0,09261839 ! regulation of immune effector process GO:0002697 137 71 1,000 0,0543161 0,0925528 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,05567949 0,09480881 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 1,000 0,05567949 0,09474176 ! carbohydrate transport GO:0008643 110 72 1,000 0,05567949 0,0946748 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 1,000 0,05567949 0,09460794 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 1,000 0,05567949 0,09454117 ! negative regulation of muscle development GO:0048635 20 11 0,000 0,05657372 0,09599179 ! respiratory burst GO:0045730 17 11 0,000 0,05657372 0,09592414 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,05657372 0,09585659 ! neuron fate specification GO:0048665 17 11 0,000 0,05657372 0,09578913 ! telencephalon cell migration GO:0022029 20 11 0,000 0,05657372 0,09572177 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,05657372 0,0956545 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,05657372 0,09558733 ! thyroid gland development GO:0030878 26 11 0,000 0,05657372 0,09552025 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 0,000 0,05657372 0,09545327 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,05657372 0,09538638 ! response to pain GO:0048265 24 11 0,000 0,05657372 0,09531958 ! blood vessel remodeling GO:0001974 29 11 0,000 0,05657372 0,09525288 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 0,000 0,05657372 0,09518626 ! bone resorption GO:0045453 16 11 0,000 0,05657372 0,09511975 ! ventral spinal cord development GO:0021517 21 11 0,000 0,05657372 0,09505332 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05657372 0,09498699 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05657372 0,09492075 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,05657372 0,09485461 ! melanocyte differentiation GO:0030318 21 11 0,000 0,05657372 0,09478855 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,05657372 0,09472259 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,05657372 0,09465672 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,05657372 0,09459094 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,05657372 0,09452525 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,05657372 0,09445965 ! lipid digestion GO:0044241 18 11 0,000 0,05657372 0,09439415 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,05657372 0,09432873 ! UV protection GO:0009650 19 11 0,000 0,05657372 0,09426341 ! chondrocyte differentiation GO:0002062 24 11 0,000 0,05657372 0,09419817 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05657372 0,09413303 ! temperature homeostasis GO:0001659 17 11 0,000 0,05657372 0,09406797 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,05657372 0,09400301 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,05657372 0,09393814 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,05657372 0,09387335 ! regulation of organ growth GO:0046620 13 11 0,000 0,05657372 0,09380866 ! pigment granule localization GO:0051875 20 11 0,000 0,05657372 0,09374405 ! vasoconstriction GO:0042310 18 11 0,000 0,05657372 0,09367953 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05657372 0,0936151 ! embryonic axis specification GO:0000578 18 11 0,000 0,05657372 0,09355076 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,05657372 0,09348651 ! snRNA metabolic process GO:0016073 24 11 0,000 0,05657372 0,09342235 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05657372 0,09335827 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,05657372 0,09329428 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,05657372 0,09323038 ! zymogen activation GO:0031638 15 11 0,000 0,05657372 0,09316657 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,05657372 0,09310284 ! nucleosome positioning GO:0016584 15 11 0,000 0,05657372 0,09303921 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,05657372 0,09297565 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,05657372 0,09291219 ! regulation of leukocyte migration GO:0002685 26 11 0,000 0,05657372 0,09284881 ! acid secretion GO:0046717 18 11 0,000 0,05657372 0,09278552 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05657372 0,09272232 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,05657372 0,0926592 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,05657372 0,09259616 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,05657372 0,09253321 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,05657372 0,09247035 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,05657372 0,09240758 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,05657372 0,09234488 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05657372 0,09228228 ! negative regulation of glucose import GO:0046325 17 11 0,000 0,05657372 0,09221976 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 25 11 0,000 0,05657372 0,09215732 ! embryonic gut development GO:0048566 15 11 0,000 0,05657372 0,09209497 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,05657372 0,0920327 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,05657372 0,09197051 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,05657372 0,09190841 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,05657372 0,0918464 ! defense response to fungus GO:0050832 13 11 0,000 0,05657372 0,09178446 ! developmental induction GO:0031128 19 11 0,000 0,05657372 0,09172261 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,05657372 0,09166085 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05657372 0,09159916 ! sequestering of metal ion GO:0051238 14 11 0,000 0,05657372 0,09153756 ! lamellipodium assembly GO:0030032 20 11 0,000 0,05657372 0,09147605 ! nucleus localization GO:0051647 19 11 0,000 0,05657372 0,09141461 ! regulation of synapse organization GO:0050807 17 11 0,000 0,05657372 0,09135326 ! axon guidance GO:0007411 139 73 1,000 0,05705484 0,09206838 ! leukocyte mediated immunity GO:0002443 128 74 1,000 0,05844202 0,09424363 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 1,000 0,05984085 0,09643475 ! rhythmic process GO:0048511 128 75 1,000 0,05984085 0,0963702 ! cytosolic calcium ion homeostasis GO:0051480 135 76 1,000 0,06125117 0,09857546 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,06155627 0,09900026 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,06155627 0,09893412 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,06155627 0,09886808 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,06155627 0,09880212 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,06155627 0,09873626 ! cartilage condensation GO:0001502 20 12 0,000 0,06155627 0,09867048 ! regulation of positive chemotaxis GO:0050926 19 12 0,000 0,06155627 0,09860478 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,06155627 0,09853918 ! protein complex disassembly GO:0043241 27 12 0,000 0,06155627 0,09847366 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06155627 0,09840823 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,06155627 0,09834288 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,06155627 0,09827763 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,06155627 0,09821246 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06155627 0,09814737 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,06155627 0,09808237 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,06155627 0,09801746 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,06155627 0,09795264 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,06155627 0,09788789 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,06155627 0,09782324 ! drug transport GO:0015893 16 12 0,000 0,06155627 0,09775867 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,06155627 0,09769418 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,06155627 0,09762979 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,06155627 0,09756547 ! polyamine metabolic process GO:0006595 17 12 0,000 0,06155627 0,09750124 ! mitotic spindle organization GO:0007052 21 12 0,000 0,06155627 0,09743709 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,06155627 0,09737303 ! forebrain cell migration GO:0021885 21 12 0,000 0,06155627 0,09730906 ! asymmetric protein localization GO:0008105 20 12 0,000 0,06155627 0,09724516 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,06155627 0,09718135 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,06155627 0,09711763 ! entry into host cell GO:0030260 32 12 0,000 0,06155627 0,09705399 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,06155627 0,09699043 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06155627 0,09692695 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,06155627 0,09686356 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,06155627 0,09680025 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,06155627 0,09673702 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06155627 0,09667388 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,06155627 0,09661082 ! protein homotetramerization GO:0051289 21 12 0,000 0,06155627 0,09654784 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,06155627 0,09648494 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,06155627 0,09642213 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06155627 0,09635939 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,06155627 0,09629674 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,06155627 0,09623417 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06155627 0,09617168 ! cranial nerve development GO:0021545 20 12 0,000 0,06155627 0,09610927 ! fucose catabolic process GO:0019317 22 12 0,000 0,06155627 0,09604694 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,06155627 0,09598469 ! histone methylation GO:0016571 26 12 0,000 0,06155627 0,09592253 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,06155627 0,09586044 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06155627 0,09579844 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,06155627 0,09573651 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,06155627 0,09567467 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,06155627 0,0956129 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,06155627 0,09555122 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,06155627 0,09548961 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,06155627 0,09542808 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,06155627 0,09536664 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 0,000 0,06155627 0,09530527 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,06155627 0,09524398 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,06155627 0,09518277 ! positive regulation of ligase activity GO:0051351 124 77 1,000 0,06267283 0,09684702 ! negative regulation of organelle organization GO:0010639 161 78 1,000 0,06410566 0,09899757 ! protein oligomerization GO:0051259 139 78 1,000 0,06410566 0,09893407 ! positive regulation of phosphorylation GO:0042327 129 79 1,000 0,06554952 0,10109753 ! cGMP metabolic process GO:0046068 18 13 0,000 0,06651267 0,10251729 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,06651267 0,10245166 ! regulation of chemokine production GO:0032642 18 13 0,000 0,06651267 0,10238611 ! peroxisomal transport GO:0043574 24 13 0,000 0,06651267 0,10232065 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,06651267 0,10225527 ! lipid localization GO:0010876 28 13 0,000 0,06651267 0,10218997 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,06651267 0,10212476 ! organelle fusion GO:0048284 32 13 0,000 0,06651267 0,10205963 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,06651267 0,10199458 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,06651267 0,10192961 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,06651267 0,10186473 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,06651267 0,10179993 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,06651267 0,10173521 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,06651267 0,10167058 ! methionine metabolic process GO:0006555 27 13 0,000 0,06651267 0,10160603 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,06651267 0,10154156 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,06651267 0,10147717 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,06651267 0,10141286 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,06651267 0,10134863 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,06651267 0,10128449 ! cytokine metabolic process GO:0042107 22 13 0,000 0,06651267 0,10122043 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,06651267 0,10115644 ! exocrine system development GO:0035272 32 13 0,000 0,06651267 0,10109254 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,06651267 0,10102872 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,06651267 0,10096498 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,06651267 0,10090132 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,06651267 0,10083774 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,06651267 0,10077424 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,06651267 0,10071082 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,06651267 0,10064748 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,06651267 0,10058422 ! regulation of cellular pH GO:0030641 22 13 0,000 0,06651267 0,10052104 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,06651267 0,10045794 ! ribosome assembly GO:0042255 17 13 0,000 0,06651267 0,10039491 ! regulation of monooxygenase activity GO:0032768 33 13 0,000 0,06651267 0,10033197 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,06651267 0,10026911 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,06651267 0,10020632 ! chromatin silencing GO:0006342 26 13 0,000 0,06651267 0,10014361 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,06651267 0,10008098 ! regulation of epidermis development GO:0045682 19 13 0,000 0,06651267 0,10001843 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,06651267 0,09995596 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,06651267 0,09989357 ! regulation of mRNA stability GO:0043488 31 13 0,000 0,06651267 0,09983125 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,06651267 0,09976901 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,06651267 0,09970685 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,06651267 0,09964477 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,06651267 0,09958276 ! embryonic placenta development GO:0001892 23 13 0,000 0,06651267 0,09952083 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,06651267 0,09945898 ! insulin secretion GO:0030073 23 13 0,000 0,06651267 0,0993972 ! actin filament polymerization GO:0030041 24 13 0,000 0,06651267 0,0993355 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,06651267 0,09927388 ! acrosome reaction GO:0007340 18 13 0,000 0,06651267 0,09921233 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,06700424 0,09988365 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 1,000 0,06846968 0,10200499 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,06994568 0,10413943 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,06994568 0,10407503 ! regulation of lyase activity GO:0051339 160 83 1,000 0,0714321 0,10622103 ! rRNA transcription GO:0009303 25 14 0,000 0,07144306 0,10617172 ! lactation GO:0007595 26 14 0,000 0,07144306 0,10610618 ! reproductive cellular process GO:0048610 20 14 0,000 0,07144306 0,10604072 ! tRNA modification GO:0006400 20 14 0,000 0,07144306 0,10597535 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,07144306 0,10591005 ! water transport GO:0006833 21 14 0,000 0,07144306 0,10584484 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,07144306 0,1057797 ! non-recombinational repair GO:0000726 25 14 0,000 0,07144306 0,10571465 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,07144306 0,10564967 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,07144306 0,10558477 ! RNA polyadenylation GO:0043631 30 14 0,000 0,07144306 0,10551996 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,07144306 0,10545522 ! palate development GO:0060021 31 14 0,000 0,07144306 0,10539057 ! regulated secretory pathway GO:0045055 23 14 0,000 0,07144306 0,10532599 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,07144306 0,10526149 ! arginine metabolic process GO:0006525 17 14 0,000 0,07144306 0,10519707 ! regulation of heart rate GO:0002027 24 14 0,000 0,07144306 0,10513273 ! organic alcohol transport GO:0015850 29 14 0,000 0,07144306 0,10506847 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,07144306 0,10500428 ! embryo implantation GO:0007566 30 14 0,000 0,07144306 0,10494018 ! neutral amino acid transport GO:0015804 26 14 0,000 0,07144306 0,10487615 ! L-amino acid transport GO:0015807 30 14 0,000 0,07144306 0,1048122 ! bone mineralization GO:0030282 17 14 0,000 0,07144306 0,10474833 ! stem cell development GO:0048864 43 14 0,000 0,07144306 0,10468454 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,07144306 0,10462082 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07144306 0,10455719 ! cerebellum development GO:0021549 21 14 0,000 0,07144306 0,10449363 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,07144306 0,10443014 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,07144306 0,10436674 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,07144306 0,10430341 ! cofactor transport GO:0051181 26 14 0,000 0,07144306 0,10424015 ! NADP metabolic process GO:0006739 24 14 0,000 0,07144306 0,10417698 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,07144306 0,10411388 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,07144306 0,10405086 ! intestinal absorption GO:0050892 25 14 0,000 0,07144306 0,10398791 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,07144306 0,10392504 ! oxygen transport GO:0015671 21 14 0,000 0,07144306 0,10386224 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07144306 0,10379953 ! male genitalia development GO:0030539 24 14 0,000 0,07144306 0,10373688 ! regulation of RNA stability GO:0043487 32 14 0,000 0,07144306 0,10367431 ! regulation of axon extension GO:0030516 37 14 0,000 0,07144306 0,10361182 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,07144306 0,10354941 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,07292877 0,10563915 ! negative regulation of transport GO:0051051 153 84 1,000 0,07292877 0,10557559 ! response to unfolded protein GO:0006986 131 85 1,000 0,07443556 0,1076921 ! tube morphogenesis GO:0035239 176 86 1,000 0,07595232 0,10982048 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,07634758 0,11032569 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,07634758 0,11025947 ! superoxide anion generation GO:0042554 20 15 0,000 0,07634758 0,11019332 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,07634758 0,11012726 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,07634758 0,11006128 ! copper ion transport GO:0006825 20 15 0,000 0,07634758 0,10999537 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,07634758 0,10992955 ! sulfate transport GO:0008272 23 15 0,000 0,07634758 0,1098638 ! response to cAMP GO:0051591 22 15 0,000 0,07634758 0,10979813 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,07634758 0,10973254 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,07634758 0,10966703 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,07634758 0,10960159 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,07634758 0,10953624 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,07634758 0,10947096 ! response to hexose stimulus GO:0009746 22 15 0,000 0,07634758 0,10940576 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,07634758 0,10934064 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,07634758 0,10927559 ! regulation of the force of heart contraction GO:0002026 26 15 0,000 0,07634758 0,10921063 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,07634758 0,10914573 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,07634758 0,10908092 ! regulation of exocytosis GO:0017157 22 15 0,000 0,07634758 0,10901618 ! G1/S transition checkpoint GO:0031575 40 15 0,000 0,07634758 0,10895153 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,07634758 0,10888694 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,07634758 0,10882244 ! regulation of vasodilation GO:0042312 26 15 0,000 0,07634758 0,10875801 ! mRNA splice site selection GO:0006376 38 15 0,000 0,07634758 0,10869365 ! tissue regeneration GO:0042246 26 15 0,000 0,07634758 0,10862937 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,07634758 0,10856517 ! water homeostasis GO:0030104 27 15 0,000 0,07634758 0,10850105 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,07634758 0,108437 ! muscle maintenance GO:0046716 26 15 0,000 0,07634758 0,10837302 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,07634758 0,10830912 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,07634758 0,1082453 ! dopamine metabolic process GO:0042417 35 15 0,000 0,07634758 0,10818155 ! heme biosynthetic process GO:0006783 29 15 0,000 0,07634758 0,10811788 ! cell killing GO:0001906 29 15 0,000 0,07634758 0,10805428 ! detection of bacterium GO:0016045 18 15 0,000 0,07634758 0,10799075 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,07634758 0,1079273 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,07634758 0,10786393 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,07634758 0,10780063 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,07634758 0,1077374 ! peptide hormone processing GO:0016486 23 15 0,000 0,07634758 0,10767425 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,0774789 0,10920576 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! positive regulation of protein modification process GO:0031401 136 88 1,000 0,07901515 0,11130589 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,08122635 0,11435377 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,08122635 0,1142869 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,08122635 0,1142201 ! bone remodeling GO:0046849 27 16 0,000 0,08122635 0,11415338 ! filopodium assembly GO:0046847 32 16 0,000 0,08122635 0,11408674 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,08122635 0,11402018 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,08122635 0,1139537 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,08122635 0,11388729 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,08122635 0,11382096 ! startle response GO:0001964 28 16 0,000 0,08122635 0,11375471 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,08122635 0,11368854 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,08122635 0,11362244 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,08122635 0,11355642 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,08122635 0,11349047 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,08122635 0,1134246 ! protein polyubiquitination GO:0000209 34 16 0,000 0,08122635 0,11335881 ! glutamate metabolic process GO:0006536 22 16 0,000 0,08122635 0,1132931 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,08122635 0,11322746 ! response to osmotic stress GO:0006970 25 16 0,000 0,08122635 0,11316189 ! negative regulation of microtubule depolymerization GO:0007026 46 16 0,000 0,08122635 0,11309641 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 26 16 0,000 0,08122635 0,113031 ! fructose metabolic process GO:0006000 25 16 0,000 0,08122635 0,11296566 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08122635 0,1129004 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08122635 0,11283521 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,08122635 0,11277011 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,08122635 0,11270507 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,08122635 0,11264011 ! DNA replication initiation GO:0006270 27 16 0,000 0,08122635 0,11257523 ! neuron recognition GO:0008038 35 16 0,000 0,08122635 0,11251042 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,08122635 0,11244568 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,08122635 0,11238102 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,08122635 0,11231643 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,08122635 0,11225192 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,08122635 0,11218748 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,08122635 0,11212312 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,08122635 0,11205883 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08122635 0,11199461 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,08122635 0,11193047 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,08122635 0,1118664 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,08211612 0,11302711 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,08607951 0,11841469 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,08607951 0,11834703 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,08607951 0,11827944 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,08607951 0,11821193 ! signal complex assembly GO:0007172 41 17 0,000 0,08607951 0,11814449 ! endothelial cell migration GO:0043542 28 17 0,000 0,08607951 0,11807714 ! inositol metabolic process GO:0006020 28 17 0,000 0,08607951 0,11800986 ! gene silencing by RNA GO:0031047 36 17 0,000 0,08607951 0,11794265 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,08607951 0,11787553 ! glial cell development GO:0021782 27 17 0,000 0,08607951 0,11780847 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,08607951 0,1177415 ! adult walking behavior GO:0007628 33 17 0,000 0,08607951 0,1176746 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,08607951 0,11760778 ! heart looping GO:0001947 30 17 0,000 0,08607951 0,11754103 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,08607951 0,11747436 ! myoblast differentiation GO:0045445 45 17 0,000 0,08607951 0,11740777 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,08607951 0,11734125 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 0,000 0,08607951 0,1172748 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,08607951 0,11720843 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,08607951 0,11714214 ! glycine metabolic process GO:0006544 28 17 0,000 0,08607951 0,11707592 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,08607951 0,11700977 ! NAD metabolic process GO:0019674 29 17 0,000 0,08607951 0,1169437 ! DNA integration GO:0015074 29 17 0,000 0,08607951 0,11687771 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,08607951 0,11681179 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,08607951 0,11674594 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,08607951 0,11668017 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,08607951 0,11661447 ! genitalia development GO:0048806 30 17 0,000 0,08607951 0,11654885 ! neural crest cell migration GO:0001755 37 17 0,000 0,08607951 0,11648329 ! neutrophil chemotaxis GO:0030593 27 17 0,000 0,08607951 0,11641782 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,08607951 0,11635241 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,08607951 0,11628709 ! steroid catabolic process GO:0006706 31 17 0,000 0,08607951 0,11622183 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,08607951 0,11615665 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,08607951 0,11609154 ! gas transport GO:0015669 25 17 0,000 0,08607951 0,1160265 ! organic cation transport GO:0015695 31 17 0,000 0,08607951 0,11596153 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,08607951 0,11589664 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,08607951 0,11583182 ! microspike assembly GO:0030035 36 17 0,000 0,08607951 0,11576708 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 0,000 0,08607951 0,1157024 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 1,000 0,08683661 0,11665488 GO:0010498|proteasomal protein catabolic process, ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,08683661 0,11658978 ! negative regulation of multicellular organismal process GO:0051241 166 93 1,000 0,08683661 0,11652476 ! female pregnancy GO:0007565 164 94 1,000 0,08842797 0,11859403 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,0909072 0,12185109 ! neuron maturation GO:0042551 42 18 0,000 0,0909072 0,12178325 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,0909072 0,12171548 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,0909072 0,12164778 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,0909072 0,12158016 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,0909072 0,12151262 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,0909072 0,12144515 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,0909072 0,12137775 ! patterning of blood vessels GO:0001569 39 18 0,000 0,0909072 0,12131043 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,0909072 0,12124319 GO:0042744|hydrogen peroxide catabolic process, ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,0909072 0,12117602 ! glutamine metabolic process GO:0006541 29 18 0,000 0,0909072 0,12110892 ! response to retinoic acid GO:0032526 26 18 0,000 0,0909072 0,1210419 ! response to fungus GO:0009620 21 18 0,000 0,0909072 0,12097495 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,0909072 0,12090808 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,0909072 0,12084128 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,0909072 0,12077455 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,0909072 0,1207079 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,0909072 0,12064132 ! vitamin transport GO:0051180 27 18 0,000 0,0909072 0,12057481 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,0909072 0,12050838 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,0909072 0,12044202 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,0909072 0,12037574 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,0909072 0,12030952 ! nerve development GO:0021675 28 18 0,000 0,0909072 0,12024338 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,0909072 0,12017731 ! positive regulation of immune response GO:0050778 156 96 1,000 0,09163664 0,1210751 ! detection of stimulus GO:0051606 151 96 1,000 0,09163664 0,12100865 ! protein ubiquitination GO:0016567 217 97 1,000 0,09325369 0,12307645 ! protein secretion GO:0009306 39 19 0,000 0,09570954 0,12624844 ! positive regulation of translation GO:0045727 30 19 0,000 0,09570954 0,12617926 ! negative regulation of defense response GO:0031348 25 19 0,000 0,09570954 0,12611016 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,09570954 0,12604113 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,09570954 0,12597218 ! skin development GO:0043588 36 19 0,000 0,09570954 0,12590331 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,09570954 0,12583451 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,09570954 0,12576578 ! bile acid metabolic process GO:0008206 29 19 0,000 0,09570954 0,12569714 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,09570954 0,12562856 ! cerebral cortex development GO:0021987 36 19 0,000 0,09570954 0,12556006 ! pigmentation during development GO:0048066 41 19 0,000 0,09570954 0,12549164 ! response to vitamin A GO:0033189 27 19 0,000 0,09570954 0,12542329 ! heme metabolic process GO:0042168 36 19 0,000 0,09570954 0,12535501 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,09570954 0,12528681 ! plasma membrane fusion GO:0045026 28 19 0,000 0,09570954 0,12521868 ! regulation of endothelial cell migration GO:0010594 44 19 0,000 0,09570954 0,12515063 ! peptide cross-linking GO:0018149 37 19 0,000 0,09570954 0,12508265 ! protein export from nucleus GO:0006611 36 19 0,000 0,09570954 0,12501474 ! heart process GO:0003015 30 19 0,000 0,09570954 0,12494691 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,09570954 0,12487915 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,09570954 0,12481146 ! visual learning GO:0008542 36 19 0,000 0,09570954 0,12474385 ! cell-cell junction organization GO:0045216 35 19 0,000 0,09570954 0,12467631 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,09570954 0,12460885 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,09570954 0,12454146 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,09570954 0,12447414 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,09570954 0,12440689 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,09570954 0,12433971 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,09570954 0,12427261 ! cilium assembly GO:0042384 37 19 0,000 0,09570954 0,12420558 ! peptide hormone secretion GO:0030072 31 19 0,000 0,09570954 0,12413863 ! Golgi vesicle transport GO:0048193 207 99 1,000 0,09651255 0,12511272 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,10048667 0,13019437 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,10048667 0,13012429 ! positive regulation of ossification GO:0045778 47 20 0,000 0,10048667 0,1300543 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,10048667 0,12998437 ! cAMP metabolic process GO:0046058 36 20 0,000 0,10048667 0,12991453 ! response to vitamin GO:0033273 31 20 0,000 0,10048667 0,12984476 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,10048667 0,12977506 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,10048667 0,12970544 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,10048667 0,12963589 ! retinoid metabolic process GO:0001523 32 20 0,000 0,10048667 0,12956642 GO:0016101|diterpenoid metabolic process, ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,10048667 0,12949702 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,10048667 0,1294277 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,10048667 0,12935845 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 0,000 0,10048667 0,12928927 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,10048667 0,12922017 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,10048667 0,12915114 ! body fluid secretion GO:0007589 31 20 0,000 0,10048667 0,12908219 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,10048667 0,12901331 ! peptide secretion GO:0002790 35 20 0,000 0,10048667 0,1289445 ! stem cell differentiation GO:0048863 53 20 0,000 0,10048667 0,12887577 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,10048667 0,12880711 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,10048667 0,12873852 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,10048667 0,12867 ! sensory perception of pain GO:0019233 30 20 0,000 0,10048667 0,12860156 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,10048667 0,12853319 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,10048667 0,1284649 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,10048667 0,12839667 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,10048667 0,12832852 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,10048667 0,12826044 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,10048667 0,12819244 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,10048667 0,1281245 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,10048667 0,12805664 ! regulation of glucose import GO:0046324 29 20 0,000 0,10048667 0,12798885 GO:0010827|regulation of glucose transport, ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,10048667 0,12792113 ! actin filament-based movement GO:0030048 43 20 0,000 0,10048667 0,12785348 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,10048667 0,12778591 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,10048667 0,1277184 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,10048667 0,12765097 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,10523873 0,13361709 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,10523873 0,13354662 ! hormone secretion GO:0046879 38 21 0,000 0,10523873 0,13347622 ! glycerol metabolic process GO:0006071 34 21 0,000 0,10523873 0,13340589 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,10523873 0,13333564 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,10523873 0,13326546 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,10523873 0,13319536 ! axis specification GO:0009798 38 21 0,000 0,10523873 0,13312533 ! inactivation of MAPK activity GO:0000188 39 21 0,000 0,10523873 0,13305538 ! smooth muscle contraction GO:0006939 46 21 0,000 0,10523873 0,13298549 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,10523873 0,13291569 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,10523873 0,13284595 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,10523873 0,13277629 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,10523873 0,1327067 ! cytolysis GO:0019835 24 21 0,000 0,10523873 0,13263718 ! vasodilation GO:0042311 39 21 0,000 0,10523873 0,13256774 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,10523873 0,13249837 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,10523873 0,13242907 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,10523873 0,13235984 ! positive regulation of locomotion GO:0040017 39 21 0,000 0,10523873 0,13229069 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 59 21 0,000 0,10523873 0,13222161 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,10523873 0,1321526 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,10523873 0,13208366 ! positive regulation of inflammatory response GO:0050729 35 21 0,000 0,10523873 0,1320148 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,10523873 0,131946 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,10523873 0,13187728 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,10523873 0,13180863 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,10523873 0,13174005 ! collagen catabolic process GO:0030574 28 21 0,000 0,10523873 0,13167155 ! sperm-egg recognition GO:0035036 21 21 0,000 0,10523873 0,13160311 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,10996584 0,13744302 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,10996584 0,13737165 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,10996584 0,13730037 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,10996584 0,13722915 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 40 22 0,000 0,10996584 0,13715801 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,10996584 0,13708695 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,10996584 0,13701595 ! keratinization GO:0031424 28 22 0,000 0,10996584 0,13694503 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,10996584 0,13687419 ! sensory perception of taste GO:0050909 28 22 0,000 0,10996584 0,13680341 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,10996584 0,13673272 ! vacuolar transport GO:0007034 36 22 0,000 0,10996584 0,13666209 ! lysosome organization GO:0007040 41 22 0,000 0,10996584 0,13659154 ! central nervous system neuron development GO:0021954 46 22 0,000 0,10996584 0,13652105 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,10996584 0,13645065 ! fucose metabolic process GO:0006004 39 22 0,000 0,10996584 0,13638031 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,10996584 0,13631005 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,10996584 0,13623986 GO:0060415|muscle tissue morphogenesis, ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,10996584 0,13616974 ! sarcomere organization GO:0045214 30 22 0,000 0,10996584 0,13609969 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,10996584 0,13602972 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,10996584 0,13595982 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,10996584 0,13588999 ! protein stabilization GO:0050821 39 22 0,000 0,10996584 0,13582023 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,11466813 0,14155542 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,11466813 0,14148283 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,11466813 0,14141031 ! gluconeogenesis GO:0006094 33 23 0,000 0,11466813 0,14133787 ! viral genome replication GO:0019079 41 23 0,000 0,11466813 0,1412655 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,11466813 0,1411932 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,11466813 0,14112098 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,11466813 0,14104883 GO:0006044|N-acetylglucosamine metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,11466813 0,14097676 ! visual behavior GO:0007632 42 23 0,000 0,11466813 0,14090476 ! peroxisome organization GO:0007031 37 23 0,000 0,11466813 0,14083283 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,11466813 0,14076098 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,11466813 0,1406892 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,11466813 0,14061749 GO:0051693|actin filament capping, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,11466813 0,14054586 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,11466813 0,14047429 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,11466813 0,14040281 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,11466813 0,14033139 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,11466813 0,14026005 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,11466813 0,14018878 ! fatty acid transport GO:0015908 44 23 0,000 0,11466813 0,14011758 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,11466813 0,14004645 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,11466813 0,1399754 ! hormone transport GO:0009914 40 23 0,000 0,11466813 0,13990442 ! cell-cell recognition GO:0009988 25 23 0,000 0,11466813 0,13983351 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,11466813 0,13976267 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,11466813 0,13969191 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,11466813 0,13962121 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,11466813 0,13955059 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,11466813 0,13948004 ! protein import into nucleus, translocation GO:0000060 46 24 0,000 0,11934573 0,14509643 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,11934573 0,14502314 GO:0016444|somatic cell DNA recombination, ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,11934573 0,14494994 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,11934573 0,1448768 ! vesicle docking GO:0048278 47 24 0,000 0,11934573 0,14480375 ! spinal cord development GO:0021510 47 24 0,000 0,11934573 0,14473076 ! vacuole organization GO:0007033 43 24 0,000 0,11934573 0,14465785 ! digestive system process GO:0022600 39 24 0,000 0,11934573 0,14458501 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,11934573 0,14451224 ! regulation of behavior GO:0050795 43 24 0,000 0,11934573 0,14443955 ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,11934573 0,14436693 ! membrane depolarization GO:0051899 39 24 0,000 0,11934573 0,14429439 ! pentose metabolic process GO:0019321 35 24 0,000 0,11934573 0,14422191 ! regulation of oxidoreductase activity GO:0051341 46 24 0,000 0,11934573 0,14414951 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,11934573 0,14407718 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,11934573 0,14400493 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,11934573 0,14393275 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,11934573 0,14386063 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,11934573 0,1437886 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,11934573 0,14371663 ! regulation of amine transport GO:0051952 40 24 0,000 0,11934573 0,14364474 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,12399877 0,14917052 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,12399877 0,14909598 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,12399877 0,1490215 ! phototransduction GO:0007602 33 25 0,000 0,12399877 0,1489471 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,12399877 0,14887278 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,12399877 0,14879853 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,12399877 0,14872435 ! receptor metabolic process GO:0043112 46 25 0,000 0,12399877 0,14865025 ! chromosome condensation GO:0030261 45 25 0,000 0,12399877 0,14857622 ! response to starvation GO:0042594 42 25 0,000 0,12399877 0,14850226 ! osteoblast differentiation GO:0001649 60 25 0,000 0,12399877 0,14842838 ! neural crest cell development GO:0014032 54 25 0,000 0,12399877 0,14835457 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,12399877 0,14828084 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,12399877 0,14820718 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,12399877 0,14813359 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,12399877 0,14806007 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 0,000 0,12399877 0,14798663 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,12399877 0,14791326 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,12399877 0,14783996 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,12399877 0,14776674 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,12399877 0,14769359 ! cellular response to nutrient levels GO:0031669 41 25 0,000 0,12399877 0,14762051 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,12399877 0,1475475 ! telomere organization GO:0032200 43 25 0,000 0,12399877 0,14747457 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,12399877 0,1474017 GO:0060606|tube closure, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,12862739 0,15282839 ! embryonic pattern specification GO:0009880 44 26 0,000 0,12862739 0,15275296 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,12862739 0,1526776 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,12862739 0,15260231 ! initiation of viral infection GO:0019059 57 26 0,000 0,12862739 0,1525271 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,12862739 0,15245197 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,12862739 0,1523769 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,12862739 0,15230191 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,12862739 0,152227 ! tube lumen formation GO:0035148 50 26 0,000 0,12862739 0,15215216 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,12862739 0,15207739 ! regulation of transcription factor import into nucleus GO:0042990 54 26 0,000 0,12862739 0,1520027 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,12862739 0,15192808 ! regulation of endothelial cell proliferation GO:0001936 57 26 0,000 0,12862739 0,15185353 ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,12862739 0,15177905 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,12862739 0,15170465 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,12862739 0,15163032 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,12862739 0,15155607 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,12862739 0,15148188 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,12862739 0,15140777 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,12862739 0,15133374 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,12862739 0,15125977 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 0,000 0,13323169 0,15659768 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,13323169 0,15652122 ! iron ion transport GO:0006826 59 27 0,000 0,13323169 0,15644483 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 0,000 0,13323169 0,15636851 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,13323169 0,15629227 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,13323169 0,15621611 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,13323169 0,15614002 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,13323169 0,156064 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,13323169 0,15598806 ! autophagy GO:0006914 41 27 0,000 0,13323169 0,15591219 ! primary neural tube formation GO:0014020 51 27 0,000 0,13323169 0,15583639 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,13323169 0,15576067 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,13323169 0,15568502 ! glutathione metabolic process GO:0006749 39 27 0,000 0,13323169 0,15560944 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,13323169 0,15553394 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,13323169 0,15545851 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,13781183 0,16072479 ! circadian rhythm GO:0007623 50 28 0,000 0,13781183 0,16064692 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,13781183 0,16056913 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 59 28 0,000 0,13781183 0,16049141 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,13781183 0,16041376 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,13781183 0,1603362 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,13781183 0,1602587 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,13781183 0,16018128 ! synaptogenesis GO:0007416 42 28 0,000 0,13781183 0,16010394 ! lipid oxidation GO:0034440 43 28 0,000 0,13781183 0,16002667 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,13781183 0,15994947 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,13781183 0,15987235 ! translational initiation GO:0006413 65 29 0,000 0,14236791 0,16507816 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,14236791 0,16499864 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,14236791 0,1649192 ! regulation of pH GO:0006885 43 29 0,000 0,14236791 0,16483984 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,14236791 0,16476055 ! catechol metabolic process GO:0009712 54 29 0,000 0,14236791 0,16468134 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,14236791 0,1646022 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,14236791 0,16452314 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,14236791 0,16444416 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,14236791 0,16436525 ! detection of light stimulus GO:0009583 38 29 0,000 0,14236791 0,16428642 ! regulation of coagulation GO:0050818 46 29 0,000 0,14236791 0,16420766 ! phenol metabolic process GO:0018958 55 30 0,000 0,14690006 0,16935388 ! zinc ion transport GO:0006829 45 30 0,000 0,14690006 0,16927277 ! membrane docking GO:0022406 61 30 0,000 0,14690006 0,16919174 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,14690006 0,16911079 ! regulation of innate immune response GO:0045088 51 30 0,000 0,14690006 0,16902991 ! acute-phase response GO:0006953 49 30 0,000 0,14690006 0,16894912 ! myofibril assembly GO:0030239 47 30 0,000 0,14690006 0,16886839 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,14690006 0,16878775 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,14690006 0,16870718 ! phospholipid transport GO:0015914 51 30 0,000 0,14690006 0,16862669 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,14690006 0,16854628 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,14690006 0,16846594 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,14690006 0,16838568 ! eye morphogenesis GO:0048592 60 30 0,000 0,14690006 0,1683055 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,15140842 0,17338822 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,15140842 0,17330573 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,15140842 0,17322333 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,15140842 0,17314099 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,15140842 0,17305874 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,15140842 0,17297657 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,15140842 0,17289447 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,15140842 0,17281245 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,15140842 0,17273051 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,15140842 0,17264865 ! peptide transport GO:0015833 55 31 0,000 0,15140842 0,17256687 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,15140842 0,17248516 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,15140842 0,17240353 ! mesoderm formation GO:0001707 69 31 0,000 0,15140842 0,17232197 ! natural killer cell activation GO:0030101 45 31 0,000 0,15140842 0,1722405 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,15140842 0,1721591 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,15140842 0,17207778 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,1558931 0,17709103 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,1558931 0,17700745 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,1558931 0,17692396 ! cholesterol transport GO:0030301 56 32 0,000 0,1558931 0,17684054 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,1558931 0,17675721 ! spliceosome assembly GO:0000245 67 32 0,000 0,1558931 0,17667395 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,1558931 0,17659077 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,1558931 0,17650767 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,1558931 0,17642464 ! regulation of protein import into nucleus GO:0042306 63 32 0,000 0,1558931 0,1763417 ! muscle cell development GO:0055001 49 32 0,000 0,1558931 0,17625883 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,1558931 0,17617604 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,1558931 0,17609333 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,1558931 0,1760107 ! negative regulation of MAP kinase activity GO:0043407 69 32 0,000 0,1558931 0,17592814 ! BMP signaling pathway GO:0030509 64 32 0,000 0,1558931 0,17584566 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,1558931 0,17576326 ! gene silencing GO:0016458 65 32 0,000 0,1558931 0,17568093 ! DNA damage checkpoint GO:0000077 71 33 0,000 0,16035422 0,18062372 ! positive regulation of gene-specific transcription GO:0043193 65 33 0,000 0,16035422 0,1805392 ! protein targeting to membrane GO:0006612 68 33 0,000 0,16035422 0,18045475 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,16035422 0,18037039 ! ceramide metabolic process GO:0006672 64 33 0,000 0,16035422 0,1802861 ! formation of primary germ layer GO:0001704 72 33 0,000 0,16035422 0,1802019 ! cell fate specification GO:0001708 52 33 0,000 0,16035422 0,18011777 ! sterol transport GO:0015918 57 33 0,000 0,16035422 0,18003372 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,16035422 0,17994975 ! adult locomotory behavior GO:0008344 59 33 0,000 0,16035422 0,17986586 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,16479192 0,18475739 ! glial cell differentiation GO:0010001 63 34 0,000 0,16479192 0,18467134 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,16479192 0,18458536 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,16479192 0,18449947 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,16479192 0,18441366 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,16479192 0,18432792 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,16479192 0,18424227 ! mismatch repair GO:0006298 46 34 0,000 0,16479192 0,18415669 ! spermatid development GO:0007286 63 34 0,000 0,16479192 0,1840712 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,16479192 0,18398578 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,16479192 0,18390045 ! placenta development GO:0001890 53 34 0,000 0,16479192 0,18381519 ! negative regulation of secretion GO:0051048 63 35 0,000 0,16920631 0,18865171 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,16920631 0,18856433 ! odontogenesis GO:0042476 66 35 0,000 0,16920631 0,18847703 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,16920631 0,18838981 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,16920631 0,18830267 GO:0006639|acylglycerol metabolic process, ! negative regulation of hydrolase activity GO:0051346 62 35 0,000 0,16920631 0,18821562 ! calcium-mediated signaling GO:0019722 62 35 0,000 0,16920631 0,18812864 ! cytokine production GO:0001816 59 35 0,000 0,16920631 0,18804175 ! neural tube formation GO:0001841 67 35 0,000 0,16920631 0,18795493 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,17359751 0,19274371 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,17359751 0,19265481 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,17359751 0,19256598 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,17359751 0,19247724 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,17359751 0,19238859 ! regulation of proteolysis GO:0030162 72 36 0,000 0,17359751 0,19230001 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,17359751 0,19221151 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,17359751 0,1921231 ! aerobic respiration GO:0009060 55 36 0,000 0,17359751 0,19203477 ! androgen receptor signaling pathway GO:0030521 74 36 0,000 0,17359751 0,19194652 ! embryonic organ development GO:0048568 57 36 0,000 0,17359751 0,19185835 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,17359751 0,19177026 ! RNA export from nucleus GO:0006405 56 37 0,000 0,17796565 0,19650544 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,17796565 0,1964153 ! actomyosin structure organization GO:0031032 62 37 0,000 0,17796565 0,19632525 ! organic anion transport GO:0015711 68 37 0,000 0,17796565 0,19623527 ! tissue remodeling GO:0048771 76 37 0,000 0,17796565 0,19614538 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,17796565 0,19605557 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,17796565 0,19596584 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,17796565 0,1958762 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,17796565 0,19578663 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 66 37 0,000 0,17796565 0,19569715 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,18231085 0,20038369 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,18231085 0,20029219 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,18231085 0,20020078 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,18231085 0,20010944 ! mitotic cell cycle checkpoint GO:0007093 76 38 0,000 0,18231085 0,20001819 ! lipid homeostasis GO:0055088 67 38 0,000 0,18231085 0,19992703 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,18231085 0,19983595 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,18231085 0,19974495 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,18231085 0,19965403 ! embryonic epithelial tube formation GO:0001838 72 38 0,000 0,18231085 0,19956319 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,18231085 0,19947244 ! mRNA catabolic process GO:0006402 71 39 0,000 0,18663322 0,20410887 ! learning GO:0007612 77 39 0,000 0,18663322 0,20401614 ! organic ether metabolic process GO:0018904 55 39 0,000 0,18663322 0,20392349 ! ion transmembrane transport GO:0034220 66 39 0,000 0,18663322 0,20383092 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,18663322 0,20373844 ! RNA modification GO:0009451 57 39 0,000 0,18663322 0,20364604 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,18663322 0,20355373 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,19093288 0,20814885 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,19093288 0,20805458 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,19093288 0,2079604 ! feeding behavior GO:0007631 59 40 0,000 0,19093288 0,2078663 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,19093288 0,20777228 ! maintenance of protein location GO:0045185 91 40 0,000 0,19093288 0,20767835 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,19520996 0,2122346 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,19520996 0,21213874 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,19520996 0,21204296 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,19520996 0,21194728 ! gliogenesis GO:0042063 88 41 0,000 0,19520996 0,21185168 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,19520996 0,21175616 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,19520996 0,21166073 ! polyol metabolic process GO:0019751 66 41 0,000 0,19520996 0,21156539 ! negative regulation of protein complex disassembly GO:0043242 101 42 0,000 0,19946457 0,21607913 ! regulation of tube size GO:0035150 71 42 0,000 0,19946457 0,21598189 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,19946457 0,21588473 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,19946457 0,21578766 ! neuron migration GO:0001764 79 42 0,000 0,19946457 0,21569068 ! regulation of protein secretion GO:0050708 71 42 0,000 0,19946457 0,21559378 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,19946457 0,21549697 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,20369683 0,21997063 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,20369683 0,21987195 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,20369683 0,21977335 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,20369683 0,21967484 ! positive regulation of response to external stimulus GO:0032103 77 43 0,000 0,20369683 0,21957642 ! striated muscle contraction GO:0006941 77 43 0,000 0,20369683 0,21947809 ! phagocytosis GO:0006909 90 43 0,000 0,20369683 0,21937984 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,20369683 0,21928169 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,20790685 0,22371372 ! JAK-STAT cascade GO:0007259 71 44 0,000 0,20790685 0,22361371 ! maintenance of location in cell GO:0051651 97 44 0,000 0,20790685 0,2235138 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,21209475 0,22791424 ! glycolysis GO:0006096 65 45 0,000 0,21209475 0,22781249 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,21209475 0,22771083 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,21209475 0,22760927 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,21209475 0,22750779 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,21209475 0,22740641 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,21209475 0,22730511 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,21209475 0,22720391 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,21626065 0,23156348 ! positive regulation of defense response GO:0031349 76 47 0,000 0,22040466 0,23589574 ! endosome transport GO:0016197 108 47 0,000 0,22040466 0,23579085 ! vascular process in circulatory system GO:0003018 80 47 0,000 0,22040466 0,23568605 ! JNK cascade GO:0007254 91 47 0,000 0,22040466 0,23558135 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,22040466 0,23547674 ! protein homooligomerization GO:0051260 76 47 0,000 0,22040466 0,23537222 ! morphogenesis of embryonic epithelium GO:0016331 91 48 0,000 0,2245269 0,23966802 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,2245269 0,23956174 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,2245269 0,23945555 ! regulation of inflammatory response GO:0050727 75 48 0,000 0,2245269 0,23934946 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,22862748 0,2436128 ! regulation of protein complex disassembly GO:0043244 113 49 0,000 0,22862748 0,24350496 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,22862748 0,24339722 ! regulation of ion transport GO:0043269 77 49 0,000 0,22862748 0,24328957 ! induction of apoptosis by extracellular signals GO:0008624 89 49 0,000 0,22862748 0,24318201 ! peptide metabolic process GO:0006518 76 49 0,000 0,22862748 0,24307455 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,22862748 0,24296719 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,22862748 0,24285991 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,22862748 0,24275274 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,2327065 0,24697479 ! neuromuscular process GO:0050905 99 50 0,000 0,2327065 0,2468659 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,2327065 0,2467571 ! viral infectious cycle GO:0019058 99 51 0,000 0,2367641 0,25094908 ! embryonic skeletal system development GO:0048706 85 51 0,000 0,2367641 0,25083858 ! excretion GO:0007588 83 51 0,000 0,2367641 0,25072818 ! chromatin remodeling GO:0006338 109 51 0,000 0,2367641 0,25061787 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,2367641 0,25050766 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,2367641 0,25039755 ! regulation of cell shape GO:0008360 125 51 0,000 0,2367641 0,25028753 ! regulation of muscle contraction GO:0006937 81 52 0,000 0,24080037 0,25444255 ! membrane fusion GO:0006944 110 52 0,000 0,24080037 0,25433085 ! amino acid activation GO:0043038 92 52 0,000 0,24080037 0,25421926 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! cartilage development GO:0051216 90 52 0,000 0,24080037 0,25410776 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,24481543 0,25823144 ! RNA catabolic process GO:0006401 93 53 0,000 0,24481543 0,25811828 ! regulation of translational initiation GO:0006446 82 53 0,000 0,24481543 0,25800522 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,24481543 0,25789226 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,24481543 0,2577794 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,24481543 0,25766663 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,24481543 0,25755397 ! activation of phospholipase C activity GO:0007202 103 54 0,000 0,24880939 0,26164134 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 0,000 0,24880939 0,26152703 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,24880939 0,26141283 ! cell recognition GO:0008037 85 54 0,000 0,24880939 0,26129873 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,24880939 0,26118472 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,24880939 0,26107082 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,24880939 0,26095701 ! chloride transport GO:0006821 90 55 0,000 0,25278235 0,26500843 ! glucose catabolic process GO:0006007 82 55 0,000 0,25278235 0,26489301 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,25278235 0,26477768 ! positive regulation of phospholipase activity GO:0010518 104 55 0,000 0,25278235 0,26466246 ! gastrulation GO:0007369 112 55 0,000 0,25278235 0,26454734 ! nuclear export GO:0051168 97 55 0,000 0,25278235 0,26443232 ! regulation of actin filament length GO:0030832 105 56 0,000 0,25673444 0,26844983 ! sensory perception of smell GO:0007608 80 56 0,000 0,25673444 0,26833321 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,25673444 0,2682167 ! proton transport GO:0015992 94 56 0,000 0,25673444 0,26810029 ! regulation of phospholipase activity GO:0010517 106 57 0,000 0,26066575 0,27208755 ! maintenance of location GO:0051235 118 57 0,000 0,26066575 0,27196956 ! hydrogen transport GO:0006818 97 58 0,000 0,2645764 0,27593014 ! regulation of endocytosis GO:0030100 91 58 0,000 0,2645764 0,27581058 ! adult behavior GO:0030534 99 58 0,000 0,2645764 0,27569113 ! positive regulation of lipase activity GO:0060193 108 58 0,000 0,2645764 0,27557179 ! positive regulation of secretion GO:0051047 95 59 0,000 0,2684665 0,27950255 ! regulation of cellular component size GO:0032535 109 59 0,000 0,2684665 0,27938166 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,2684665 0,27926087 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,2684665 0,27914019 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,27233614 0,28304137 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,27233614 0,28291915 ! regulation of heart contraction GO:0008016 110 60 0,000 0,27233614 0,28279705 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,27618545 0,28667049 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,27618545 0,28654687 ! mesoderm development GO:0007498 119 61 0,000 0,27618545 0,28642336 ! tRNA processing GO:0008033 89 61 0,000 0,27618545 0,28629995 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,27618545 0,28617665 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,28001452 0,29001934 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,28382346 0,29383788 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,28382346 0,2937115 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,28382346 0,29358523 ! steroid hormone receptor signaling pathway GO:0030518 129 63 0,000 0,28382346 0,29345906 ! cell redox homeostasis GO:0045454 102 64 0,000 0,28761237 0,29724887 ! single fertilization GO:0007338 75 64 0,000 0,28761237 0,29712124 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,29138137 0,30088565 ! myeloid cell differentiation GO:0030099 111 65 0,000 0,29138137 0,30075657 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,29513055 0,30449576 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,29513055 0,30436524 ! extracellular matrix organization GO:0030198 133 66 0,000 0,29513055 0,30423483 ! cell projection assembly GO:0030031 120 66 0,000 0,29513055 0,30410454 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,29886002 0,30781558 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,29886002 0,30768387 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,29886002 0,30755227 ! hexose catabolic process GO:0019320 104 67 0,000 0,29886002 0,30742078 ! amino acid transport GO:0006865 125 68 0,000 0,30256988 0,3111039 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,30256988 0,310971 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 0,000 0,30256988 0,31083822 ! regulation of lipase activity GO:0060191 130 68 0,000 0,30256988 0,31070556 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,30256988 0,310573 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,30626023 0,31422691 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,30626023 0,31409297 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,30626023 0,31395914 ! amine catabolic process GO:0009310 117 71 0,000 0,31358282 0,3213289 ! acute inflammatory response GO:0002526 113 72 0,000 0,31721526 0,32491269 ! regulation of blood pressure GO:0008217 125 73 0,000 0,3208286 0,32847388 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,3208286 0,32833416 ! fertilization GO:0009566 90 73 0,000 0,3208286 0,32819456 ! transition metal ion transport GO:0000041 126 74 0,000 0,32442294 0,33173038 ! neurotransmitter transport GO:0006836 123 74 0,000 0,32442294 0,33158946 ! exocytosis GO:0006887 133 74 0,000 0,32442294 0,33144866 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,32442294 0,33130797 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,32799837 0,33481717 ! defense response to bacterium GO:0042742 89 76 0,000 0,331555 0,33830421 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,331555 0,3381608 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,331555 0,33801751 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,33509292 0,3414797 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,33509292 0,34133513 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,34211304 0,34833854 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,34211304 0,34819119 ! activation of protein kinase activity GO:0032147 147 79 0,000 0,34211304 0,34804397 ! regulation of synaptic transmission GO:0050804 134 79 0,000 0,34211304 0,34789686 ! muscle cell differentiation GO:0042692 159 80 0,000 0,34559543 0,35128965 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,34559543 0,3511413 ! protein import into nucleus GO:0006606 158 80 0,000 0,34559543 0,35099308 ! inorganic anion transport GO:0015698 138 80 0,000 0,34559543 0,35084498 ! digestion GO:0007586 112 81 0,000 0,3490595 0,35421222 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,3490595 0,35406289 ! nuclear import GO:0051170 161 81 0,000 0,3490595 0,35391368 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,35250535 0,3572569 ! regulation of transmission of nerve impulse GO:0051969 141 84 0,000 0,35934277 0,36403313 ! nucleosome assembly GO:0006334 122 85 0,000 0,36273452 0,3673145 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,36610843 0,37057504 ! chromatin assembly GO:0031497 124 86 0,000 0,36610843 0,37041921 ! alcohol catabolic process GO:0046164 130 86 0,000 0,36610843 0,3702635 ! amine transport GO:0015837 155 86 0,000 0,36610843 0,37010793 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,36946458 0,37334388 ! protein localization in nucleus GO:0034504 176 87 0,000 0,36946458 0,37318715 ! cellular respiration GO:0045333 135 88 0,000 0,37280308 0,37640127 ! regulation of neurological system process GO:0031644 148 88 0,000 0,37280308 0,37624338 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,37280308 0,37608563 ! cellular defense response GO:0006968 114 89 0,000 0,37612402 0,37927677 ! regulation of cell morphogenesis GO:0022604 215 89 0,000 0,37612402 0,37911788 ! ossification GO:0001503 188 90 0,000 0,37942748 0,38228748 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,37942748 0,38212746 ! bone development GO:0060348 189 91 0,000 0,38271355 0,38527565 ! sterol metabolic process GO:0016125 152 91 0,000 0,38271355 0,38511452 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,38271355 0,38495352 ! regulation of defense response GO:0031347 149 92 0,000 0,38598234 0,38807919 ! nucleosome organization GO:0034728 138 92 0,000 0,38598234 0,38791709 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,38598234 0,38775512 ! vitamin metabolic process GO:0006766 139 92 0,000 0,38598234 0,38759328 ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,38923392 0,39069538 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,39246839 0,39377771 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,39568585 0,39684041 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,39888636 0,39988358 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,39888636 0,39971703 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,40207004 0,4027396 ! hormone metabolic process GO:0042445 157 97 0,000 0,40207004 0,402572 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,40523695 0,40557409 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,40523695 0,40540545 GO:0016054|organic acid catabolic process, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,4083872 0,4083872