pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6607-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 6,000 1,751E-08 4,277E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 1,311E-07 1,602E-04 ! insulin receptor signaling pathway GO:0008286 66 27 4,000 2,454E-07 1,999E-04 ! regulation of B cell proliferation GO:0030888 22 12 3,000 3,188E-07 1,947E-04 ! regulation of DNA metabolic process GO:0051052 188 97 6,000 7,162E-07 3,499E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 6,000 7,679E-07 3,127E-04 ! response to peptide hormone stimulus GO:0043434 129 64 5,000 9,723E-07 3,393E-04 ! phospholipid scrambling GO:0017121 8 5 2,000 1,311E-06 4,002E-04 ! cellular response to insulin stimulus GO:0032869 85 38 4,000 1,458E-06 3,957E-04 ! cell-substrate junction assembly GO:0007044 56 18 3,000 1,924E-06 4,7E-04 ! T cell differentiation GO:0030217 93 42 4,000 2,43E-06 5,397E-04 ! L-serine biosynthetic process GO:0006564 7 6 2,000 2,611E-06 5,316E-04 ! apoptotic mitochondrial changes GO:0008637 42 20 3,000 3,022E-06 5,679E-04 ! response to insulin stimulus GO:0032868 98 47 4,000 4,292E-06 7,49E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 4,553E-06 7,415E-04 ! response to metal ion GO:0010038 158 84 5,000 4,844E-06 7,395E-04 ! response to calcium ion GO:0051592 94 49 4,000 5,292E-06 7,605E-04 ! regulation of mast cell proliferation GO:0070666 89 49 4,000 5,292E-06 7,182E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 6,523E-06 8,387E-04 ! response to inorganic substance GO:0010035 173 90 5,000 7,233E-06 8,835E-04 ! regulation of cell cycle process GO:0010564 161 90 5,000 7,233E-06 8,414E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 7,257E-06 8,058E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 7,257E-06 7,708E-04 ! gland development GO:0048732 220 91 5,000 7,711E-06 7,849E-04 ! regulation of leukocyte proliferation GO:0070663 97 53 4,000 7,833E-06 7,654E-04 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 9,104E-06 8,554E-04 GO:0045936|negative regulation of phosphate metabolic process, ! response to UV GO:0009411 120 55 4,000 9,417E-06 8,521E-04 ! regulation of DNA replication GO:0006275 105 56 4,000 1,03E-05 8,985E-04 ! T cell selection GO:0045058 27 9 2,000 1,084E-05 9,135E-04 ! nucleotide-excision repair GO:0006289 91 57 4,000 1,124E-05 9,154E-04 ! DNA catabolic process GO:0006308 94 60 4,000 1,448E-05 1,141E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 1,543E-05 1,178E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 2,000 1,543E-05 1,142E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 1,543E-05 1,109E-03 ! regulation of B cell activation GO:0050864 55 30 3,000 1,642E-05 1,146E-03 ! cell junction assembly GO:0034329 85 31 3,000 1,878E-05 1,275E-03 ! integrin-mediated signaling pathway GO:0007229 160 64 4,000 1,989E-05 1,313E-03 ! L-serine metabolic process GO:0006563 21 11 2,000 2,114E-05 1,359E-03 ! oocyte development GO:0048599 20 11 2,000 2,114E-05 1,324E-03 ! focal adhesion formation GO:0048041 37 12 2,000 2,808E-05 1,715E-03 ! oocyte differentiation GO:0009994 21 12 2,000 2,808E-05 1,673E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 2,808E-05 1,633E-03 GO:0042130|negative regulation of T cell proliferation, ! plasma membrane organization GO:0007009 27 13 2,000 3,637E-05 2,066E-03 ! cell junction organization GO:0034330 96 37 3,000 3,849E-05 2,137E-03 ! reproductive structure development GO:0048608 131 75 4,000 4,301E-05 2,335E-03 ! cell-matrix adhesion GO:0007160 181 76 4,000 4,585E-05 2,435E-03 ! lymphocyte differentiation GO:0030098 193 76 4,000 4,585E-05 2,383E-03 ! regulation of S phase GO:0033261 26 14 2,000 4,611E-05 2,347E-03 ! T cell differentiation in the thymus GO:0033077 37 14 2,000 4,611E-05 2,299E-03 ! response to gamma radiation GO:0010332 30 14 2,000 4,611E-05 2,253E-03 ! serine family amino acid biosynthetic process GO:0009070 19 14 2,000 4,611E-05 2,209E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 4,611E-05 2,166E-03 ! regulation of calcium-mediated signaling GO:0050848 29 14 2,000 4,611E-05 2,125E-03 ! regulation of T cell differentiation GO:0045580 78 42 3,000 6,394E-05 2,893E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 6,606E-05 2,934E-03 ! regulation of T cell proliferation GO:0042129 80 43 3,000 7,021E-05 3,063E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 7,041E-05 3,018E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! T cell activation GO:0042110 189 84 4,000 7,413E-05 3,122E-03 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 7,844E-05 3,248E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 8,41E-05 3,424E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 8,517E-05 3,411E-03 ! pigmentation GO:0043473 103 46 3,000 9,174E-05 3,615E-03 ! defense response to virus GO:0051607 43 18 2,000 1,018E-04 3,948E-03 ! positive regulation of cell cycle GO:0045787 96 48 3,000 1,085E-04 4,142E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 1,177E-04 4,424E-03 ! negative regulation of immune system process GO:0002683 101 51 3,000 1,377E-04 5,097E-03 ! sex differentiation GO:0007548 171 96 4,000 1,397E-04 5,093E-03 ! response to alkaloid GO:0043279 38 20 2,000 1,412E-04 5,072E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 1,412E-04 4,999E-03 ! negative regulation of T cell activation GO:0050868 41 20 2,000 1,412E-04 4,927E-03 ! negative regulation of translation GO:0017148 32 20 2,000 1,412E-04 4,858E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 1,539E-04 5,223E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 1,641E-04 5,491E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 1,893E-04 6,249E-03 ! cell aging GO:0007569 48 22 2,000 1,893E-04 6,166E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 1,893E-04 6,085E-03 ! positive regulation of B cell activation GO:0050871 42 22 2,000 1,893E-04 6,006E-03 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 2,000 2,169E-04 6,792E-03 ! regulation of cell-matrix adhesion GO:0001952 81 23 2,000 2,169E-04 6,706E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 2,169E-04 6,622E-03 ! aging GO:0007568 112 58 3,000 2,274E-04 6,858E-03 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 2,469E-04 7,356E-03 ! sex determination GO:0007530 48 24 2,000 2,469E-04 7,267E-03 ! oogenesis GO:0048477 44 24 2,000 2,469E-04 7,181E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 2,581E-04 7,419E-03 GO:0045844|positive regulation of striated muscle development, ! neuron fate determination GO:0048664 7 5 1,000 2,581E-04 7,332E-03 ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 2,581E-04 7,248E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 2,581E-04 7,166E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 2,581E-04 7,085E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 2,581E-04 7,007E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 2,581E-04 6,93E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 2,581E-04 6,854E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 2,581E-04 6,781E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 2,581E-04 6,708E-03 ! negative regulation of T cell mediated immunity GO:0002710 15 5 1,000 2,581E-04 6,638E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 1,000 2,581E-04 6,569E-03 ! B cell homeostasis GO:0001782 13 5 1,000 2,581E-04 6,501E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 1,000 2,581E-04 6,435E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 2,581E-04 6,37E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 2,581E-04 6,306E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 2,581E-04 6,243E-03 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 1,000 2,581E-04 6,182E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! stem cell division GO:0017145 11 5 1,000 2,581E-04 6,122E-03 GO:0048103|somatic stem cell division, ! leukocyte adhesion GO:0007159 55 25 2,000 2,795E-04 6,566E-03 ! vasculogenesis GO:0001570 49 25 2,000 2,795E-04 6,504E-03 ! negative regulation of DNA replication GO:0008156 45 25 2,000 2,795E-04 6,442E-03 ! lymphocyte proliferation GO:0046651 55 25 2,000 2,795E-04 6,382E-03 ! regulation of homeostatic process GO:0032844 148 62 3,000 2,942E-04 6,656E-03 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 3,148E-04 7,055E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 3,528E-04 7,836E-03 ! leukocyte proliferation GO:0070661 59 27 2,000 3,528E-04 7,765E-03 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 3,528E-04 7,696E-03 ! ear development GO:0043583 114 66 3,000 3,741E-04 8,089E-03 ! gonad development GO:0008406 115 66 3,000 3,741E-04 8,018E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 3,859E-04 8,197E-03 ! thymic T cell selection GO:0045061 16 6 1,000 3,859E-04 8,127E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 1,000 3,859E-04 8,057E-03 ! T cell mediated immunity GO:0002456 17 6 1,000 3,859E-04 7,989E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 3,859E-04 7,922E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of spindle localization GO:0051293 16 6 1,000 3,859E-04 7,856E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 3,859E-04 7,791E-03 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 1,000 3,859E-04 7,727E-03 ! response to UV-C GO:0010225 14 6 1,000 3,859E-04 7,664E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 3,859E-04 7,602E-03 ! neural tube patterning GO:0021532 8 6 1,000 3,859E-04 7,542E-03 ! cytoplasmic microtubule organization GO:0031122 18 6 1,000 3,859E-04 7,482E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 3,859E-04 7,423E-03 ! negative regulation of cell growth GO:0030308 142 67 3,000 3,963E-04 7,564E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 4,374E-04 8,284E-03 ! response to organic cyclic substance GO:0014070 58 29 2,000 4,374E-04 8,221E-03 ! negative regulation of neuron differentiation GO:0045665 46 29 2,000 4,374E-04 8,158E-03 ! negative regulation of cell size GO:0045792 144 69 3,000 4,435E-04 8,207E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 4,435E-04 8,146E-03 ! urogenital system development GO:0001655 149 69 3,000 4,435E-04 8,085E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 4,685E-04 8,478E-03 ! germ cell development GO:0007281 133 70 3,000 4,685E-04 8,415E-03 ! tissue homeostasis GO:0001894 50 30 2,000 4,842E-04 8,635E-03 GO:0048871|multicellular organismal homeostasis, ! male gonad development GO:0008584 56 31 2,000 5,341E-04 9,455E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 5,341E-04 9,387E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 5,384E-04 9,395E-03 ! prostate gland development GO:0030850 14 7 1,000 5,384E-04 9,329E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 5,384E-04 9,263E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 5,384E-04 9,198E-03 ! positive regulation of isotype switching GO:0045830 17 7 1,000 5,384E-04 9,134E-03 GO:0045911|positive regulation of DNA recombination, ! organ growth GO:0035265 15 7 1,000 5,384E-04 9,071E-03 ! male sex determination GO:0030238 15 7 1,000 5,384E-04 9,009E-03 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 5,384E-04 8,948E-03 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 5,384E-04 8,887E-03 ! centrosome duplication GO:0051298 14 7 1,000 5,384E-04 8,828E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 5,384E-04 8,769E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 5,384E-04 8,711E-03 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 1,000 5,384E-04 8,653E-03 GO:0002714|positive regulation of B cell mediated immunity, ! peptidyl-threonine modification GO:0018210 26 7 1,000 5,384E-04 8,597E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 5,384E-04 8,541E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 1,000 5,384E-04 8,486E-03 ! negative regulation of transferase activity GO:0051348 155 74 3,000 5,786E-04 9,061E-03 ! metanephros development GO:0001656 81 32 2,000 5,871E-04 9,136E-03 ! hindbrain development GO:0030902 65 32 2,000 5,871E-04 9,078E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 5,871E-04 9,021E-03 ! response to ionizing radiation GO:0010212 74 33 2,000 6,434E-04 9,824E-03 ! serine family amino acid metabolic process GO:0009069 56 34 2,000 7,03E-04 0,01066784 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 7,155E-04 0,01078927 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 7,155E-04 0,01072308 ! male meiosis GO:0007140 9 8 1,000 7,155E-04 0,0106577 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 7,155E-04 0,01059311 ! pigment granule organization GO:0048753 17 8 1,000 7,155E-04 0,01052929 ! ER overload response GO:0006983 13 8 1,000 7,155E-04 0,01046624 ! regulation of pigmentation during development GO:0048070 25 8 1,000 7,155E-04 0,01040394 ! melanin metabolic process GO:0006582 17 8 1,000 7,155E-04 0,01034238 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 7,155E-04 0,01028154 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 7,155E-04 0,01022142 ! response to UV-B GO:0010224 17 8 1,000 7,155E-04 0,01016199 ! regulation of respiratory burst GO:0060263 12 8 1,000 7,155E-04 0,01010325 ! positive regulation of ATPase activity GO:0032781 13 8 1,000 7,155E-04 0,01004519 ! blastocyst growth GO:0001832 19 8 1,000 7,155E-04 9,988E-03 ! B cell receptor signaling pathway GO:0050853 22 8 1,000 7,155E-04 9,931E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 1,000 7,155E-04 9,875E-03 ! negative regulation of DNA replication initiation GO:0032297 10 8 1,000 7,155E-04 9,819E-03 GO:0000076|DNA replication checkpoint, ! negative regulation of DNA metabolic process GO:0051053 65 35 2,000 7,661E-04 0,01045528 ! development of primary sexual characteristics GO:0045137 143 80 3,000 7,766E-04 0,01054023 ! female gonad development GO:0008585 71 37 2,000 9,026E-04 0,01218315 ! negative regulation of cell activation GO:0050866 69 37 2,000 9,026E-04 0,01211621 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 9,168E-04 0,0122387 ! regulation of glycolysis GO:0006110 20 9 1,000 9,168E-04 0,01217219 ! middle ear morphogenesis GO:0042474 14 9 1,000 9,168E-04 0,01210639 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 9,168E-04 0,01204131 ! regulation of Notch signaling pathway GO:0008593 24 9 1,000 9,168E-04 0,01197691 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 9,168E-04 0,01191321 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 1,000 9,168E-04 0,01185017 GO:0002820|negative regulation of adaptive immune response, ! regulation of telomere maintenance GO:0032204 17 9 1,000 9,168E-04 0,0117878 ! negative regulation of growth GO:0045926 168 85 3,000 9,747E-04 0,01246698 ! regulation of neuron differentiation GO:0045664 187 85 3,000 9,747E-04 0,01240205 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 9,763E-04 0,0123585 ! regulation of protein stability GO:0031647 77 38 2,000 9,763E-04 0,0122948 ! positive regulation of leukocyte proliferation GO:0070665 70 39 2,000 1,054E-03 0,01320142 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mitochondrion organization GO:0007005 159 87 3,000 1,063E-03 0,01325013 ! mammary gland development GO:0030879 93 40 2,000 1,135E-03 0,014074 ! development of primary female sexual characteristics GO:0046545 80 40 2,000 1,135E-03 0,01400292 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 2,000 1,135E-03 0,01393256 ! regulation of developmental growth GO:0048638 16 10 1,000 1,142E-03 0,01395089 ! COPI coating of Golgi vesicle GO:0048205 23 10 1,000 1,142E-03 0,01388148 GO:0048200|Golgi transport vesicle coating, ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 1,142E-03 0,01381276 ! B cell proliferation GO:0042100 19 10 1,000 1,142E-03 0,01374472 ! multicellular organism growth GO:0035264 19 10 1,000 1,142E-03 0,01367734 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 1,142E-03 0,01361062 ! motor axon guidance GO:0008045 22 10 1,000 1,142E-03 0,01354455 ! protein heterooligomerization GO:0051291 17 10 1,000 1,142E-03 0,01347912 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,142E-03 0,01341432 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,142E-03 0,01335013 ! regulation of B cell differentiation GO:0045577 24 10 1,000 1,142E-03 0,01328656 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 1,142E-03 0,01322359 ! midbrain development GO:0030901 14 10 1,000 1,142E-03 0,01316122 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,142E-03 0,01309943 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 1,142E-03 0,01303821 ! negative regulation of immune effector process GO:0002698 23 10 1,000 1,142E-03 0,01297757 ! regulation of cell adhesion GO:0030155 241 92 3,000 1,308E-03 0,01479662 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,309E-03 0,01473503 ! cytokinesis GO:0000910 84 42 2,000 1,309E-03 0,01466743 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 1,362E-03 0,01518955 ! Golgi vesicle budding GO:0048194 26 11 1,000 1,391E-03 0,01544882 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 1,391E-03 0,01537892 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,391E-03 0,01530964 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,391E-03 0,01524099 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,391E-03 0,01517295 ! adult heart development GO:0007512 16 11 1,000 1,391E-03 0,01510551 ! behavioral fear response GO:0001662 27 11 1,000 1,391E-03 0,01503868 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 1,391E-03 0,01497243 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,391E-03 0,01490676 ! positive regulation of T cell mediated immunity GO:0002711 26 11 1,000 1,391E-03 0,01484166 ! DNA methylation GO:0006306 19 11 1,000 1,391E-03 0,01477713 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 25 11 1,000 1,391E-03 0,01471316 ! regulation of isotype switching GO:0045191 24 11 1,000 1,391E-03 0,01464974 ! thymus development GO:0048538 29 11 1,000 1,391E-03 0,01458687 ! T cell receptor signaling pathway GO:0050852 29 11 1,000 1,391E-03 0,01452453 ! regulation of embryonic development GO:0045995 35 11 1,000 1,391E-03 0,01446273 ! development of primary male sexual characteristics GO:0046546 80 43 2,000 1,402E-03 0,01451037 ! response to reactive oxygen species GO:0000302 75 44 2,000 1,499E-03 0,01544838 ! regulation of T cell activation GO:0050863 175 96 3,000 1,531E-03 0,01571461 ! transcription initiation GO:0006352 171 97 3,000 1,59E-03 0,01625744 ! regulation of protein localization GO:0032880 188 97 3,000 1,59E-03 0,01618971 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 1,6E-03 0,01621623 ! female gamete generation GO:0007292 71 45 2,000 1,6E-03 0,01614922 ! developmental growth GO:0048589 88 45 2,000 1,6E-03 0,01608276 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,664E-03 0,01665889 ! virus-host interaction GO:0019048 30 12 1,000 1,664E-03 0,01659089 ! hippocampus development GO:0021766 29 12 1,000 1,664E-03 0,01652345 ! T cell proliferation GO:0042098 32 12 1,000 1,664E-03 0,01645655 ! histone acetylation GO:0016573 27 12 1,000 1,664E-03 0,0163902 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,664E-03 0,01632437 ! T cell homeostasis GO:0043029 28 12 1,000 1,664E-03 0,01625908 ! response to cold GO:0009409 17 12 1,000 1,664E-03 0,0161943 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,705E-03 0,01652831 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 1,705E-03 0,01646298 ! negative regulation of cell migration GO:0030336 122 46 2,000 1,705E-03 0,01639816 ! cellular component disassembly GO:0022411 89 48 2,000 1,928E-03 0,0184718 ! male sex differentiation GO:0046661 93 48 2,000 1,928E-03 0,01839964 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 1,96E-03 0,01862904 GO:0000725|recombinational repair, ! endocrine pancreas development GO:0031018 25 13 1,000 1,96E-03 0,01855684 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 1,96E-03 0,01848519 ! response to X-ray GO:0010165 28 13 1,000 1,96E-03 0,01841409 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 1,96E-03 0,01834354 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 1,96E-03 0,01827353 ! gland morphogenesis GO:0022612 31 13 1,000 1,96E-03 0,01820405 ! spleen development GO:0048536 24 13 1,000 1,96E-03 0,01813509 ! digestive tract morphogenesis GO:0048546 31 13 1,000 1,96E-03 0,01806666 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! positive regulation of calcium-mediated signaling GO:0050850 28 13 1,000 1,96E-03 0,01799874 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 2,169E-03 0,01984251 ! endocrine system development GO:0035270 109 50 2,000 2,169E-03 0,01976847 ! activation of caspase activity GO:0006919 95 50 2,000 2,169E-03 0,01969498 ! regulation of gene expression, epigenetic GO:0040029 116 50 2,000 2,169E-03 0,01962204 ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 1,000 2,279E-03 0,02054182 ! hair follicle morphogenesis GO:0031069 27 14 1,000 2,279E-03 0,0204663 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 1,000 2,279E-03 0,02039133 ! fear response GO:0042596 34 14 1,000 2,279E-03 0,02031691 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 2,279E-03 0,02024303 GO:0060675|ureteric bud morphogenesis, ! response to temperature stimulus GO:0009266 84 51 2,000 2,296E-03 0,02031901 ! response to estrogen stimulus GO:0043627 98 52 2,000 2,427E-03 0,02140494 ! cellular amino acid biosynthetic process GO:0008652 80 52 2,000 2,427E-03 0,02132795 ! histone modification GO:0016570 104 52 2,000 2,427E-03 0,0212515 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 2,000 2,427E-03 0,02117561 ! positive regulation of growth GO:0045927 96 53 2,000 2,563E-03 0,02228276 ! vesicle organization GO:0016050 127 53 2,000 2,563E-03 0,02220374 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 2,62E-03 0,0226208 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 2,62E-03 0,02254115 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 2,62E-03 0,02246206 ! regulation of mRNA processing GO:0050684 26 15 1,000 2,62E-03 0,02238352 ! vesicle coating GO:0006901 38 15 1,000 2,62E-03 0,02230553 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 2,62E-03 0,02222808 ! intermediate filament cytoskeleton organization GO:0045104 34 15 1,000 2,62E-03 0,02215117 ! regulation of T cell mediated immunity GO:0002709 36 15 1,000 2,62E-03 0,02207478 ! histone deacetylation GO:0016575 24 15 1,000 2,62E-03 0,02199893 ! lymphocyte homeostasis GO:0002260 33 15 1,000 2,62E-03 0,02192359 ! covalent chromatin modification GO:0016569 115 54 2,000 2,704E-03 0,02254276 ! cell maturation GO:0048469 107 55 2,000 2,849E-03 0,02367353 ! negative regulation of cell motion GO:0051271 142 55 2,000 2,849E-03 0,02359328 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 2,985E-03 0,02463393 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 2,985E-03 0,02455099 ! heterophilic cell adhesion GO:0007157 43 16 1,000 2,985E-03 0,0244686 ! pituitary gland development GO:0021983 30 16 1,000 2,985E-03 0,02438676 ! intermediate filament-based process GO:0045103 36 16 1,000 2,985E-03 0,02430548 ! negative regulation of immune response GO:0050777 38 16 1,000 2,985E-03 0,02422473 ! axon cargo transport GO:0008088 46 16 1,000 2,985E-03 0,02414451 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 1,000 2,985E-03 0,02406483 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 2,985E-03 0,02398567 ! regulation of ATPase activity GO:0043462 26 16 1,000 2,985E-03 0,02390702 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 1,000 2,985E-03 0,0238289 ! RNA elongation GO:0006354 90 56 2,000 2,999E-03 0,02386496 ! positive regulation of caspase activity GO:0043280 108 57 2,000 3,154E-03 0,02501535 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 2,000 3,154E-03 0,02493439 ! positive regulation of cell migration GO:0030335 137 58 2,000 3,313E-03 0,02611189 ! positive regulation of cell killing GO:0031343 36 17 1,000 3,371E-03 0,0264827 ! metencephalon development GO:0022037 32 17 1,000 3,371E-03 0,02639782 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 3,371E-03 0,02631348 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 3,371E-03 0,02622968 ! auditory receptor cell differentiation GO:0042491 36 17 1,000 3,371E-03 0,02614641 ! regulation of survival gene product expression GO:0045884 38 17 1,000 3,371E-03 0,02606367 ! membrane budding GO:0006900 42 17 1,000 3,371E-03 0,02598145 ! regulation of protein binding GO:0043393 33 17 1,000 3,371E-03 0,02589974 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 1,000 3,371E-03 0,02581855 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of homeostatic process GO:0032845 36 17 1,000 3,371E-03 0,02573787 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 3,371E-03 0,02565769 ! establishment of organelle localization GO:0051656 122 59 2,000 3,478E-03 0,02638676 ! kidney development GO:0001822 133 60 2,000 3,647E-03 0,02758634 ! limbic system development GO:0021761 40 18 1,000 3,78E-03 0,02850167 ! regulation of viral genome replication GO:0045069 30 18 1,000 3,78E-03 0,02841397 ! centrosome cycle GO:0007098 26 18 1,000 3,78E-03 0,02832681 ! epidermis morphogenesis GO:0048730 43 18 1,000 3,78E-03 0,02824018 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 3,78E-03 0,02815408 ! regulation of immunoglobulin production GO:0002637 49 18 1,000 3,78E-03 0,02806851 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 3,78E-03 0,02798345 ! regulation of mitosis GO:0007088 112 63 2,000 4,185E-03 0,03089133 GO:0051783|regulation of nuclear division, ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 4,211E-03 0,03098294 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 4,211E-03 0,0308899 ! memory GO:0007613 34 19 1,000 4,211E-03 0,03079741 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 4,211E-03 0,03070548 ! neuromuscular junction development GO:0007528 43 19 1,000 4,211E-03 0,03061409 ! cellular pigmentation GO:0033059 37 19 1,000 4,211E-03 0,03052325 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 1,000 4,211E-03 0,03043294 ! proximal/distal pattern formation GO:0009954 33 19 1,000 4,211E-03 0,03034317 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 4,375E-03 0,03143516 ! positive regulation of cell motion GO:0051272 157 65 2,000 4,57E-03 0,03273725 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 4,663E-03 0,03330684 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 1,000 4,663E-03 0,03320973 ! protein amino acid deacetylation GO:0006476 34 20 1,000 4,663E-03 0,03311319 ! protein amino acid acetylation GO:0006473 41 20 1,000 4,663E-03 0,03301721 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 4,663E-03 0,03292179 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 4,663E-03 0,03282691 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 4,663E-03 0,03273258 ! pancreas development GO:0031016 40 20 1,000 4,663E-03 0,03263879 ! cellular response to unfolded protein GO:0034620 35 20 1,000 4,663E-03 0,03254554 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 1,000 4,663E-03 0,03245282 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 1,000 4,663E-03 0,03236062 ! activation of MAPK activity GO:0000187 124 67 2,000 4,974E-03 0,03442562 ! regulation of cell killing GO:0031341 46 21 1,000 5,136E-03 0,03544573 ! lipid phosphorylation GO:0046834 43 21 1,000 5,136E-03 0,03534588 ! ovarian follicle development GO:0001541 39 21 1,000 5,136E-03 0,03524659 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 5,136E-03 0,03514786 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 5,136E-03 0,03504969 ! diencephalon development GO:0021536 36 21 1,000 5,136E-03 0,03495205 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 5,136E-03 0,03485497 ! lung development GO:0030324 165 69 2,000 5,4E-03 0,03654378 ! developmental maturation GO:0021700 128 69 2,000 5,4E-03 0,03644283 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 5,631E-03 0,03789621 ! microtubule-based transport GO:0010970 59 22 1,000 5,631E-03 0,0377921 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 5,631E-03 0,03768856 ! ureteric bud development GO:0001657 50 22 1,000 5,631E-03 0,03758558 ! renal system process GO:0003014 42 22 1,000 5,631E-03 0,03748317 ! G1 phase GO:0051318 44 22 1,000 5,631E-03 0,03738131 ! positive regulation of adaptive immune response GO:0002821 42 22 1,000 5,631E-03 0,03728001 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 5,631E-03 0,03717925 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 5,631E-03 0,03707904 ! response to cytokine stimulus GO:0034097 69 22 1,000 5,631E-03 0,03697936 ! gut development GO:0048565 44 22 1,000 5,631E-03 0,03688022 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 5,631E-03 0,03678161 ! inner ear receptor cell differentiation GO:0060113 42 22 1,000 5,631E-03 0,03668353 ! cell cycle checkpoint GO:0000075 145 71 2,000 5,847E-03 0,0379901 ! respiratory tube development GO:0030323 171 72 2,000 6,079E-03 0,03938977 ! actin filament organization GO:0007015 167 72 2,000 6,079E-03 0,03928557 ! positive regulation of DNA replication GO:0045740 44 23 1,000 6,147E-03 0,03962004 ! regeneration GO:0031099 42 23 1,000 6,147E-03 0,03951577 ! regulation of DNA recombination GO:0000018 51 23 1,000 6,147E-03 0,03941206 ! response to ethanol GO:0045471 47 23 1,000 6,147E-03 0,03930888 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 6,147E-03 0,03920625 ! vesicle targeting GO:0006903 49 23 1,000 6,147E-03 0,03910415 ! DNA modification GO:0006304 36 23 1,000 6,147E-03 0,03900258 ! regulation of caspase activity GO:0043281 136 74 2,000 6,558E-03 0,04150526 ! respiratory system development GO:0060541 175 74 2,000 6,558E-03 0,04139801 ! organelle localization GO:0051640 155 74 2,000 6,558E-03 0,04129132 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 6,683E-03 0,04196979 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 6,683E-03 0,04186217 ! mechanoreceptor differentiation GO:0042490 48 24 1,000 6,683E-03 0,04175511 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 6,683E-03 0,04164859 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 6,683E-03 0,04154262 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to corticosteroid stimulus GO:0031960 46 24 1,000 6,683E-03 0,04143718 ! regulation of viral reproduction GO:0050792 41 24 1,000 6,683E-03 0,04133227 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 1,000 6,683E-03 0,0412279 GO:0002708|positive regulation of lymphocyte mediated immunity, ! pallium development GO:0021543 56 24 1,000 6,683E-03 0,04112405 ! platelet activation GO:0030168 41 24 1,000 6,683E-03 0,04102072 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 6,683E-03 0,04091791 ! regulation of transcription factor activity GO:0051090 137 75 2,000 6,806E-03 0,04156651 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 6,806E-03 0,04146285 ! eye development GO:0001654 155 75 2,000 6,806E-03 0,04135971 ! learning or memory GO:0007611 161 76 2,000 7,059E-03 0,04279312 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 7,24E-03 0,04377857 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 7,24E-03 0,04367047 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 7,24E-03 0,04356291 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 7,24E-03 0,04345588 ! interaction with host GO:0051701 66 25 1,000 7,24E-03 0,04334937 ! immunoglobulin production GO:0002377 62 25 1,000 7,24E-03 0,04324338 GO:0002440|production of molecular mediator of immune response, ! leukocyte homeostasis GO:0001776 50 25 1,000 7,24E-03 0,04313791 ! liver development GO:0001889 55 25 1,000 7,24E-03 0,04303295 ! protein tetramerization GO:0051262 57 25 1,000 7,24E-03 0,0429285 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 7,318E-03 0,04328856 ! regulation of catabolic process GO:0009894 173 77 2,000 7,318E-03 0,043184 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 7,583E-03 0,0446369 ! myelination GO:0042552 50 26 1,000 7,817E-03 0,04590465 ! molting cycle process GO:0022404 52 26 1,000 7,817E-03 0,04579456 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! microtubule organizing center organization GO:0031023 42 26 1,000 7,817E-03 0,04568501 GO:0051297|centrosome organization, ! multicellular organismal response to stress GO:0033555 61 26 1,000 7,817E-03 0,04557597 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 7,817E-03 0,04546746 ! negative regulation of cell development GO:0010721 83 26 1,000 7,817E-03 0,04535946 GO:0050768|negative regulation of neurogenesis, ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 7,817E-03 0,04525197 ! positive regulation of nuclear division GO:0051785 41 26 1,000 7,817E-03 0,04514499 GO:0045840|positive regulation of mitosis, ! blastocyst development GO:0001824 50 26 1,000 7,817E-03 0,04503852 ! blood coagulation GO:0007596 151 79 2,000 7,853E-03 0,04513907 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 2,000 7,853E-03 0,04503311 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 7,853E-03 0,04492765 ! meiosis GO:0007126 143 81 2,000 8,41E-03 0,04800214 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 2,000 8,41E-03 0,04789025 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 2,000 8,41E-03 0,04777887 ! mitochondrial membrane organization GO:0007006 60 27 1,000 8,414E-03 0,04769161 ! response to toxin GO:0009636 49 27 1,000 8,414E-03 0,04758122 ! cellular response to oxidative stress GO:0034599 43 27 1,000 8,414E-03 0,04747133 ! regulation of peptidase activity GO:0052547 150 82 2,000 8,697E-03 0,04895405 ! meiotic cell cycle GO:0051321 144 82 2,000 8,697E-03 0,04884151 ! response to drug GO:0042493 149 83 2,000 8,989E-03 0,05036949 ! response to oxygen levels GO:0070482 183 83 2,000 8,989E-03 0,05025423 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 9,031E-03 0,05037047 ! neuron fate commitment GO:0048663 52 28 1,000 9,031E-03 0,05025573 ! protein amino acid acylation GO:0043543 59 28 1,000 9,031E-03 0,05014151 ! negative regulation of protein modification process GO:0031400 66 28 1,000 9,031E-03 0,05002782 ! fat cell differentiation GO:0045444 57 28 1,000 9,031E-03 0,04991463 ! base-excision repair GO:0006284 41 28 1,000 9,031E-03 0,04980196 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 9,031E-03 0,04968979 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 9,031E-03 0,04957813 ! response to nutrient GO:0007584 135 84 2,000 9,288E-03 0,05087465 ! regulation of ligase activity GO:0051340 147 84 2,000 9,288E-03 0,05076084 ! hemostasis GO:0007599 165 85 2,000 9,592E-03 0,05230603 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 9,667E-03 0,05259988 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 9,667E-03 0,05248299 ! somitogenesis GO:0001756 52 29 1,000 9,667E-03 0,05236662 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 9,667E-03 0,05225077 ! positive regulation of cell activation GO:0050867 161 86 2,000 9,902E-03 0,05339994 GO:0002696|positive regulation of leukocyte activation, ! regulation of protein transport GO:0051223 165 87 2,000 0,0102175 0,05498097 GO:0070201|regulation of establishment of protein localization, ! immune response-activating signal transduction GO:0002757 58 30 1,000 0,01032329 0,05542814 GO:0002764|immune response-regulating signal transduction, ! cell fate determination GO:0001709 64 30 1,000 0,01032329 0,05530659 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01032329 0,05518557 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,01032329 0,05506508 GO:0043433|negative regulation of transcription factor activity, ! amine biosynthetic process GO:0009309 146 88 2,000 0,01053897 0,05609304 ! one-carbon metabolic process GO:0006730 167 88 2,000 0,01053897 0,05597109 ! regulation of DNA binding GO:0051101 167 89 2,000 0,01086625 0,05758407 ! ovulation cycle process GO:0022602 55 31 1,000 0,01099841 0,05815826 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01099841 0,05803265 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 0,01099841 0,05790758 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01099841 0,05778305 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01099841 0,05765905 GO:0008366|axon ensheathment, ! response to heat GO:0009408 54 31 1,000 0,01099841 0,05753558 ! positive regulation of immune effector process GO:0002699 78 31 1,000 0,01099841 0,05741264 ! spindle organization GO:0007051 50 32 1,000 0,0116925 0,06090569 ! positive regulation of T cell proliferation GO:0042102 60 32 1,000 0,0116925 0,0607761 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,0116925 0,06064706 ! ovulation cycle GO:0042698 57 32 1,000 0,0116925 0,06051857 ! peripheral nervous system development GO:0007422 68 32 1,000 0,0116925 0,06039063 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,0116925 0,06026322 ! leukocyte chemotaxis GO:0030595 55 33 1,000 0,01240534 0,06380262 GO:0060326|cell chemotaxis, ! negative regulation of protein transport GO:0051224 74 33 1,000 0,01240534 0,06366858 ! establishment of vesicle localization GO:0051650 67 33 1,000 0,01240534 0,0635351 ! regulation of membrane potential GO:0042391 179 94 2,000 0,0125905 0,06434853 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01313673 0,06700008 ! post-embryonic development GO:0009791 76 34 1,000 0,01313673 0,0668605 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01313673 0,0667215 ! response to protein stimulus GO:0051789 158 96 2,000 0,01332149 0,06751948 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01388647 0,07023737 ! telencephalon development GO:0021537 81 35 1,000 0,01388647 0,07009225 ! vesicle localization GO:0051648 70 35 1,000 0,01388647 0,06994773 ! forebrain development GO:0030900 210 98 2,000 0,01407622 0,07075765 ! regulation of muscle development GO:0048634 82 36 1,000 0,01465435 0,07351246 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01465435 0,07336182 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,01465435 0,0732118 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01465435 0,07306239 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01485482 0,07391103 GO:0060538|skeletal muscle organ development, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,01544016 0,07666729 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01544016 0,07651178 ! sister chromatid segregation GO:0000819 65 37 1,000 0,01544016 0,0763569 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,01544016 0,07620264 ! meiosis I GO:0007127 74 38 1,000 0,0162437 0,08000679 ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,0162437 0,07984581 ! glycogen metabolic process GO:0005977 63 38 1,000 0,0162437 0,07968548 ! pigment metabolic process GO:0042440 87 38 1,000 0,0162437 0,07952579 ! negative regulation of binding GO:0051100 71 39 1,000 0,01706478 0,08337853 ! carbohydrate homeostasis GO:0033500 59 39 1,000 0,01706478 0,08321211 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 0,01706478 0,08304635 ! glucan metabolic process GO:0044042 64 39 1,000 0,01706478 0,08288125 GO:0006073|cellular glucan metabolic process, ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,0179032 0,08678078 ! establishment or maintenance of cell polarity GO:0007163 96 41 1,000 0,01875875 0,09074778 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,01875875 0,09056844 ! mesenchymal cell development GO:0014031 94 41 1,000 0,01875875 0,0903898 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! ear morphogenesis GO:0042471 64 42 1,000 0,01963125 0,09440775 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,01963125 0,09422227 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,01963125 0,09403752 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02052049 0,09810481 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,02052049 0,0979132 ! glucose transport GO:0015758 66 43 1,000 0,02052049 0,09772234 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 1,000 0,02052049 0,09753222 ! segmentation GO:0035282 78 43 1,000 0,02052049 0,09734283 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,02142629 0,10144269 ! hexose transport GO:0008645 68 44 1,000 0,02142629 0,10124648 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 1,000 0,02142629 0,10105102 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,02234846 0,10519708 ! biopolymer methylation GO:0043414 91 45 1,000 0,02234846 0,10499477 ! B cell differentiation GO:0030183 124 45 1,000 0,02234846 0,10479325 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 1,000 0,02234846 0,10459249 ! activation of adenylate cyclase activity GO:0007190 94 46 1,000 0,0232868 0,10877563 ! leukocyte migration GO:0050900 75 46 1,000 0,0232868 0,10856804 ! cell growth GO:0016049 90 46 1,000 0,0232868 0,10836124 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,0232868 0,10815523 ! neural tube development GO:0021915 91 47 1,000 0,02424113 0,11237397 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 1,000 0,02521126 0,11664984 ! mitochondrial transport GO:0006839 94 48 1,000 0,02521126 0,11642933 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,02521126 0,11620965 ! regulation of adaptive immune response GO:0002819 92 48 1,000 0,02521126 0,1159908 ! methylation GO:0032259 97 48 1,000 0,02521126 0,11577277 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02534263 0,1161577 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02534263 0,11594018 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02534263 0,11572347 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02534263 0,11550757 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02534263 0,11529247 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02534263 0,11507817 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02534263 0,11486467 ! polyol transport GO:0015791 12 5 0,000 0,02534263 0,11465196 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02534263 0,11444003 ! response to superoxide GO:0000303 10 5 0,000 0,02534263 0,11422889 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02534263 0,11401852 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02534263 0,11380893 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02534263 0,1136001 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02534263 0,11339205 ! female meiosis GO:0007143 10 5 0,000 0,02534263 0,11318475 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02534263 0,11297821 ! hypothalamus development GO:0021854 9 5 0,000 0,02534263 0,11277242 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02534263 0,11256738 ! cobalt ion transport GO:0006824 11 5 0,000 0,02534263 0,11236308 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02534263 0,11215952 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02534263 0,1119567 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02534263 0,11175462 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02534263 0,11155326 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02534263 0,11135262 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02534263 0,11115271 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02534263 0,11095351 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02534263 0,11075502 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02534263 0,11055724 ! transposition GO:0032196 9 5 0,000 0,02534263 0,11036017 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02534263 0,1101638 ! negative chemotaxis GO:0050919 16 5 0,000 0,02534263 0,10996813 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02534263 0,10977315 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02534263 0,10957886 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02534263 0,10938526 ! behavioral response to pain GO:0048266 10 5 0,000 0,02534263 0,10919234 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02534263 0,1090001 ! Notch receptor processing GO:0007220 11 5 0,000 0,02534263 0,10880854 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02534263 0,10861764 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02534263 0,10842742 ! micturition GO:0060073 9 5 0,000 0,02534263 0,10823786 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02534263 0,10804896 ! copulation GO:0007620 9 5 0,000 0,02534263 0,10786073 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02534263 0,10767314 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02534263 0,10748621 ! bioluminescence GO:0008218 9 5 0,000 0,02534263 0,10729992 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02534263 0,10711428 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02534263 0,10692929 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02534263 0,10674493 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02534263 0,1065612 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02534263 0,1063781 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02534263 0,10619564 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02534263 0,1060138 ! grooming behavior GO:0007625 6 5 0,000 0,02534263 0,10583258 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02534263 0,10565197 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02534263 0,10547199 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02534263 0,10529261 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02534263 0,10511385 ! response to protozoan GO:0001562 13 5 0,000 0,02534263 0,10493569 ! lymph vessel development GO:0001945 10 5 0,000 0,02534263 0,10475813 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02534263 0,10458118 ! endochondral ossification GO:0001958 17 5 0,000 0,02534263 0,10440482 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02534263 0,10422905 ! single strand break repair GO:0000012 8 5 0,000 0,02534263 0,10405388 ! parathyroid gland development GO:0060017 14 5 0,000 0,02534263 0,10387929 ! anagen GO:0042640 7 5 0,000 0,02534263 0,10370529 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02534263 0,10353187 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02534263 0,10335903 ! cytokine secretion GO:0050663 15 5 0,000 0,02534263 0,10318676 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02534263 0,10301507 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02534263 0,10284395 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02534263 0,10267339 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02534263 0,10250341 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02534263 0,10233398 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02534263 0,10216511 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02534263 0,1019968 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02534263 0,10182904 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02534263 0,10166183 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02534263 0,10149517 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02534263 0,10132906 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02534263 0,10116349 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02534263 0,10099846 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02534263 0,10083397 ! microvillus organization GO:0032528 8 5 0,000 0,02534263 0,10067001 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,02534263 0,10050659 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02534263 0,10034369 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02534263 0,10018132 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02534263 0,10001948 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02534263 0,09985816 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02534263 0,09969735 ! polyol catabolic process GO:0046174 9 5 0,000 0,02534263 0,09953707 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02534263 0,0993773 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02534263 0,09921804 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02534263 0,09905929 ! muscle cell migration GO:0014812 8 5 0,000 0,02534263 0,09890105 ! mitochondrial fission GO:0000266 8 5 0,000 0,02534263 0,09874331 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02534263 0,09858608 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02534263 0,09842934 ! mRNA transcription GO:0009299 10 5 0,000 0,02534263 0,09827311 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02534263 0,09811736 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02534263 0,09796212 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02534263 0,09780736 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02534263 0,09765309 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02534263 0,0974993 ! monocyte activation GO:0042117 10 5 0,000 0,02534263 0,097346 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02534263 0,09719318 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02534263 0,09704084 ! response to food GO:0032094 6 5 0,000 0,02534263 0,09688898 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02534263 0,09673759 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02534263 0,09658667 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02534263 0,09643623 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02534263 0,09628625 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,02534263 0,09613673 ! forebrain neuron development GO:0021884 13 5 0,000 0,02534263 0,09598768 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02534263 0,0958391 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02534263 0,09569097 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02534263 0,0955433 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02534263 0,09539608 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02534263 0,09524932 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02534263 0,09510301 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02534263 0,09495714 ! lipid glycosylation GO:0030259 7 5 0,000 0,02534263 0,09481173 ! nucleobase transport GO:0015851 6 5 0,000 0,02534263 0,09466675 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02534263 0,09452222 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02534263 0,09437814 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02534263 0,09423449 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02534263 0,09409127 ! basic amino acid transport GO:0015802 12 5 0,000 0,02534263 0,09394849 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02534263 0,09380615 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02534263 0,09366423 ! actin nucleation GO:0045010 11 5 0,000 0,02534263 0,09352274 ! depurination GO:0045007 5 5 0,000 0,02534263 0,09338168 ! depyrimidination GO:0045008 10 5 0,000 0,02534263 0,09324105 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02534263 0,09310084 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02534263 0,09296105 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02534263 0,09282167 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02534263 0,09268272 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02534263 0,09254418 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02534263 0,09240605 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02534263 0,09226834 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02534263 0,09213104 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02534263 0,09199414 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02534263 0,09185765 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02534263 0,09172157 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02534263 0,09158588 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02534263 0,0914506 ! response to arsenic GO:0046685 11 5 0,000 0,02534263 0,09131572 ! mast cell degranulation GO:0043303 7 5 0,000 0,02534263 0,09118123 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02534263 0,09104714 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02534263 0,09091345 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02534263 0,09078014 ! response to mercury ion GO:0046689 8 5 0,000 0,02534263 0,09064723 ! response to cadmium ion GO:0046686 7 5 0,000 0,02534263 0,0905147 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02534263 0,09038256 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02534263 0,09025081 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02534263 0,09011944 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02534263 0,08998845 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02534263 0,08985785 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02534263 0,08972762 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02534263 0,08959777 ! decidualization GO:0046697 11 5 0,000 0,02534263 0,08946829 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02534263 0,08933919 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02534263 0,08921046 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02534263 0,0890821 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02534263 0,0889541 ! embryonic cleavage GO:0040016 6 5 0,000 0,02534263 0,08882648 ! peroxisome fission GO:0016559 5 5 0,000 0,02534263 0,08869922 ! histone demethylation GO:0016577 13 5 0,000 0,02534263 0,08857233 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02534263 0,0884458 ! mitotic recombination GO:0006312 9 5 0,000 0,02534263 0,08831962 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02534263 0,08819381 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02534263 0,08806836 ! metaphase plate congression GO:0051310 7 5 0,000 0,02534263 0,08794326 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02534263 0,08781852 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02534263 0,08769413 ! enteric nervous system development GO:0048484 8 5 0,000 0,02534263 0,08757009 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02534263 0,08744641 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02534263 0,08732307 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02534263 0,08720008 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02534263 0,08707744 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02534263 0,08695514 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02534263 0,08683318 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02534263 0,08671156 ! metaphase GO:0051323 11 5 0,000 0,02534263 0,08659029 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02534263 0,08646935 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02534263 0,08634875 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02534263 0,08622849 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02534263 0,08610856 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02534263 0,08598897 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02534263 0,0858697 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02534263 0,08575077 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02534263 0,08563217 ! response to redox state GO:0051775 6 5 0,000 0,02534263 0,08551389 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02534263 0,08539594 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02534263 0,08527832 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02534263 0,08516101 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02534263 0,08504403 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02534263 0,08492738 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02534263 0,08481104 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02534263 0,08469502 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02534263 0,08457931 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02534263 0,08446392 ! striatum development GO:0021756 14 5 0,000 0,02534263 0,08434885 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02534263 0,08423409 ! glial cell migration GO:0008347 10 5 0,000 0,02534263 0,08411964 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02534263 0,0840055 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02534263 0,08389168 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02534263 0,08377816 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02534263 0,08366494 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02534263 0,08355203 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02534263 0,08343943 ! neuroprotection GO:0043526 8 5 0,000 0,02534263 0,08332713 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02534263 0,08321513 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02534263 0,08310343 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02534263 0,08299203 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02534263 0,08288093 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02534263 0,08277013 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02534263 0,08265962 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02534263 0,08254941 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02534263 0,08243949 ! protein insertion into membrane GO:0051205 17 5 0,000 0,02534263 0,08232986 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02534263 0,08222053 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02534263 0,08211148 ! spindle assembly GO:0051225 6 5 0,000 0,02534263 0,08200272 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02534263 0,08189425 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02534263 0,08178607 ! protein palmitoylation GO:0018345 12 5 0,000 0,02534263 0,08167818 ! drug metabolic process GO:0017144 7 5 0,000 0,02534263 0,08157056 ! organ regeneration GO:0031100 7 5 0,000 0,02534263 0,08146323 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02534263 0,08135618 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02534263 0,08124942 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,02619701 0,08387851 ! positive regulation of cyclase activity GO:0031281 106 49 1,000 0,02619701 0,08376872 ! regulation of action potential GO:0001508 102 50 1,000 0,0271982 0,08685646 ! regulation of ossification GO:0030278 123 50 1,000 0,0271982 0,08674307 ! positive regulation of lyase activity GO:0051349 107 50 1,000 0,0271982 0,08662998 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,02821463 0,08975044 ! positive regulation of binding GO:0051099 88 52 1,000 0,02924613 0,09291067 ! Notch signaling pathway GO:0007219 111 52 1,000 0,02924613 0,09279001 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,02924613 0,09266966 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,02924613 0,09254962 ! inner ear development GO:0048839 89 53 1,000 0,03029253 0,09573694 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,03029253 0,09561325 ! synapse organization GO:0050808 102 53 1,000 0,03029253 0,09548988 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03033399 0,09549733 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03033399 0,09537443 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03033399 0,09525184 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03033399 0,09512956 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03033399 0,0950076 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03033399 0,09488595 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03033399 0,09476461 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03033399 0,09464359 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03033399 0,09452287 ! response to oxygen radical GO:0000305 11 6 0,000 0,03033399 0,09440246 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03033399 0,09428235 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03033399 0,09416255 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03033399 0,09404306 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03033399 0,09392386 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03033399 0,09380497 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03033399 0,09368638 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03033399 0,09356809 ! forebrain regionalization GO:0021871 9 6 0,000 0,03033399 0,0934501 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03033399 0,0933324 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03033399 0,093215 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03033399 0,0930979 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03033399 0,09298109 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03033399 0,09286457 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03033399 0,09274835 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03033399 0,09263241 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03033399 0,09251676 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03033399 0,09240141 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03033399 0,09228634 ! malate metabolic process GO:0006108 13 6 0,000 0,03033399 0,09217155 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03033399 0,09205705 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03033399 0,09194284 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03033399 0,09182891 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03033399 0,09171526 ! protein refolding GO:0042026 15 6 0,000 0,03033399 0,09160189 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03033399 0,0914888 ! opsonization GO:0008228 8 6 0,000 0,03033399 0,09137599 ! mating behavior GO:0007617 7 6 0,000 0,03033399 0,09126346 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03033399 0,0911512 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,03033399 0,09103922 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03033399 0,09092752 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03033399 0,09081609 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03033399 0,09070493 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03033399 0,09059404 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03033399 0,09048343 ! toxin metabolic process GO:0009404 11 6 0,000 0,03033399 0,09037308 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03033399 0,09026301 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03033399 0,0901532 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03033399 0,09004366 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03033399 0,08993438 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03033399 0,08982537 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03033399 0,08971662 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03033399 0,08960814 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03033399 0,08949991 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03033399 0,08939195 ! protein lipoylation GO:0009249 10 6 0,000 0,03033399 0,08928425 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03033399 0,08917681 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03033399 0,08906963 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03033399 0,0889627 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03033399 0,08885603 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03033399 0,08874961 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03033399 0,08864346 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03033399 0,08853755 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03033399 0,0884319 ! hyperosmotic response GO:0006972 10 6 0,000 0,03033399 0,08832649 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03033399 0,08822134 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03033399 0,08811644 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03033399 0,08801179 ! urea metabolic process GO:0019627 7 6 0,000 0,03033399 0,08790739 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03033399 0,08780323 ! neutrophil activation GO:0042119 7 6 0,000 0,03033399 0,08769932 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03033399 0,08759566 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03033399 0,08749224 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03033399 0,08738907 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03033399 0,08728613 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03033399 0,08718345 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03033399 0,087081 ! neuron apoptosis GO:0051402 15 6 0,000 0,03033399 0,08697879 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03033399 0,08687682 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03033399 0,08677509 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03033399 0,0866736 ! carnitine transport GO:0015879 10 6 0,000 0,03033399 0,08657235 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03033399 0,08647133 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03033399 0,08637055 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03033399 0,08627 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,03033399 0,08616968 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03033399 0,0860696 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03033399 0,08596975 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03033399 0,08587014 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03033399 0,08577075 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03033399 0,08567159 ! astrocyte development GO:0014002 16 6 0,000 0,03033399 0,08557267 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03033399 0,08547397 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03033399 0,08537549 ! interaction with symbiont GO:0051702 14 6 0,000 0,03033399 0,08527725 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03033399 0,08517923 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03033399 0,08508143 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03033399 0,08498386 ! response to copper ion GO:0046688 10 6 0,000 0,03033399 0,08488652 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03033399 0,08478939 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03033399 0,08469249 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03033399 0,08459581 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03033399 0,08449935 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03033399 0,08440311 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03033399 0,08430709 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03033399 0,08421128 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03033399 0,0841157 ! hair follicle maturation GO:0048820 8 6 0,000 0,03033399 0,08402033 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03033399 0,08392517 ! Schwann cell development GO:0014044 15 6 0,000 0,03033399 0,08383024 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03033399 0,08373551 ! response to pheromone GO:0019236 6 6 0,000 0,03033399 0,083641 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03033399 0,08354671 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03033399 0,08345262 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03033399 0,08335875 ! subpallium development GO:0021544 15 6 0,000 0,03033399 0,08326509 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03033399 0,08317164 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03033399 0,0830784 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03033399 0,08298536 ! G2 phase GO:0051319 16 6 0,000 0,03033399 0,08289254 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03033399 0,08279992 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03033399 0,08270751 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03033399 0,0826153 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03033399 0,08252331 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03033399 0,08243151 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03033399 0,08233992 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03033399 0,08224853 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03033399 0,08215735 ! receptor internalization GO:0031623 11 6 0,000 0,03033399 0,08206637 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03033399 0,08197558 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03033399 0,081885 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03033399 0,08179462 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03033399 0,08170444 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03033399 0,08161446 ! protein deubiquitination GO:0016579 16 6 0,000 0,03033399 0,08152467 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03033399 0,08143509 ! protein destabilization GO:0031648 9 6 0,000 0,03033399 0,0813457 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03033399 0,0812565 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03033399 0,0811675 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03033399 0,0810787 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03033399 0,08099009 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03033399 0,08090167 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03033399 0,08081344 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03033399 0,08072541 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03033399 0,08063757 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03033399 0,08054992 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03033399 0,08046246 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03033399 0,08037519 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03033399 0,08028811 ! neural plate development GO:0001840 9 6 0,000 0,03033399 0,08020122 ! catecholamine transport GO:0051937 9 6 0,000 0,03033399 0,08011452 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03033399 0,080028 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03033399 0,07994167 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03033399 0,07985553 ! maternal placenta development GO:0001893 12 6 0,000 0,03033399 0,07976957 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03033399 0,07968379 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03033399 0,0795982 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03033399 0,0795128 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03033399 0,07942758 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03033399 0,07934254 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03033399 0,07925768 GO:0055081|anion homeostasis, ! regulation of angiogenesis GO:0045765 125 54 1,000 0,03135364 0,08183435 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,03135364 0,08174701 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,03242929 0,08446136 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,0335193 0,0872073 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,0335193 0,08711452 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,0346235 0,08988864 ! muscle fiber development GO:0048747 131 57 1,000 0,0346235 0,08979322 ! heart morphogenesis GO:0003007 105 57 1,000 0,0346235 0,089698 ! tRNA transcription GO:0009304 17 7 0,000 0,03529992 0,09135349 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03529992 0,09125682 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03529992 0,09116035 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03529992 0,09106409 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03529992 0,09096803 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03529992 0,09087218 ! sleep GO:0030431 16 7 0,000 0,03529992 0,09077652 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03529992 0,09068107 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03529992 0,09058581 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03529992 0,09049076 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03529992 0,09039591 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03529992 0,09030125 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03529992 0,09020679 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03529992 0,09011253 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03529992 0,09001847 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03529992 0,0899246 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03529992 0,08983093 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03529992 0,08973746 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03529992 0,08964417 ! glycolipid transport GO:0046836 11 7 0,000 0,03529992 0,08955109 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03529992 0,08945819 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,03529992 0,08936549 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03529992 0,08927298 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03529992 0,08918066 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03529992 0,08908853 ! mRNA stabilization GO:0048255 18 7 0,000 0,03529992 0,08899659 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,03529992 0,08890484 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03529992 0,08881328 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03529992 0,08872191 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,03529992 0,08863072 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03529992 0,08853973 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03529992 0,08844892 ! lipoprotein transport GO:0042953 14 7 0,000 0,03529992 0,08835829 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03529992 0,08826786 ! rhythmic behavior GO:0007622 17 7 0,000 0,03529992 0,0881776 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03529992 0,08808753 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03529992 0,08799765 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03529992 0,08790795 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03529992 0,08781843 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03529992 0,08772909 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03529992 0,08763993 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03529992 0,08755096 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03529992 0,08746217 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03529992 0,08737355 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03529992 0,08728512 ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03529992 0,08719686 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03529992 0,08710878 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03529992 0,08702088 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03529992 0,08693316 ! spinal cord patterning GO:0021511 14 7 0,000 0,03529992 0,08684561 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03529992 0,08675824 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03529992 0,08667105 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03529992 0,08658403 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03529992 0,08649719 ! adrenal gland development GO:0030325 17 7 0,000 0,03529992 0,08641052 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03529992 0,08632402 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03529992 0,08623769 ! ovulation GO:0030728 10 7 0,000 0,03529992 0,08615154 ! adenohypophysis development GO:0021984 11 7 0,000 0,03529992 0,08606556 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03529992 0,08597976 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03529992 0,08589412 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03529992 0,08580865 ! microtubule nucleation GO:0007020 21 7 0,000 0,03529992 0,08572335 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03529992 0,08563823 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03529992 0,08555327 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03529992 0,08546848 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03529992 0,08538386 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03529992 0,0852994 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03529992 0,08521511 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03529992 0,08513099 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03529992 0,08504704 ! galactose metabolic process GO:0006012 13 7 0,000 0,03529992 0,08496325 ! vesicle fusion GO:0006906 20 7 0,000 0,03529992 0,08487962 ! response to dietary excess GO:0002021 8 7 0,000 0,03529992 0,08479616 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03529992 0,08471286 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03529992 0,08462973 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03529992 0,08454676 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,03529992 0,08446395 ! nucleoside transport GO:0015858 11 7 0,000 0,03529992 0,08438131 ! nucleoside salvage GO:0043174 11 7 0,000 0,03529992 0,08429882 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03529992 0,0842165 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03529992 0,08413434 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03529992 0,08405233 ! parturition GO:0007567 16 7 0,000 0,03529992 0,08397049 ! rRNA modification GO:0000154 14 7 0,000 0,03529992 0,08388881 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03529992 0,08380728 ! spindle checkpoint GO:0031577 16 7 0,000 0,03529992 0,08372592 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03529992 0,08364471 ! monocyte differentiation GO:0030224 16 7 0,000 0,03529992 0,08356366 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03529992 0,08348276 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03529992 0,08340203 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03529992 0,08332144 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03529992 0,08324102 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03529992 0,08316075 ! fibrinolysis GO:0042730 11 7 0,000 0,03529992 0,08308063 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,03529992 0,08300067 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03529992 0,08292086 ! eating behavior GO:0042755 8 7 0,000 0,03529992 0,08284121 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03529992 0,0827617 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03529992 0,08268235 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03529992 0,08260316 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03529992 0,08252411 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03529992 0,08244522 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03529992 0,08236647 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03529992 0,08228788 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03529992 0,08220943 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03529992 0,08213114 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03529992 0,08205299 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03529992 0,081975 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03529992 0,08189715 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03529992 0,08181944 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03529992 0,08174189 ! histone ubiquitination GO:0016574 9 7 0,000 0,03529992 0,08166448 ! regulation of meiosis GO:0040020 12 7 0,000 0,03529992 0,08158722 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03529992 0,08151011 ! regulation of lipid transport GO:0032368 14 7 0,000 0,03529992 0,08143314 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03529992 0,08135632 ! transcription termination GO:0006353 14 7 0,000 0,03529992 0,08127964 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03529992 0,0812031 ! anaphase GO:0051322 18 7 0,000 0,03529992 0,08112671 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03529992 0,08105047 ! axonal fasciculation GO:0007413 19 7 0,000 0,03529992 0,08097436 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03529992 0,0808984 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03529992 0,08082258 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03529992 0,08074691 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,03529992 0,08067137 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03529992 0,08059598 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03529992 0,08052072 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03529992 0,08044561 ! antibiotic transport GO:0042891 9 7 0,000 0,03529992 0,08037064 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03529992 0,08029581 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03529992 0,08022111 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03529992 0,08014656 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03529992 0,08007214 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03529992 0,07999786 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03529992 0,07992372 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03529992 0,07984972 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03529992 0,07977585 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03529992 0,07970212 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03529992 0,07962853 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03529992 0,07955507 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03529992 0,07948175 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03529992 0,07940856 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03529992 0,07933551 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03529992 0,07926259 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03529992 0,0791898 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03529992 0,07911715 ! muscle adaptation GO:0043500 13 7 0,000 0,03529992 0,07904463 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03529992 0,07897225 ! retina homeostasis GO:0001895 12 7 0,000 0,03529992 0,0789 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03529992 0,07882787 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03529992 0,07875589 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03529992 0,07868403 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03529992 0,0786123 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,03574172 0,0795237 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,03574172 0,07945134 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,03574172 0,07937911 ! lipid modification GO:0030258 112 60 1,000 0,03801952 0,08436121 ! camera-type eye development GO:0043010 126 61 1,000 0,03917877 0,08685457 ! negative regulation of response to stimulus GO:0048585 106 61 1,000 0,03917877 0,08677583 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04024055 0,0890468 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04024055 0,08896622 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04024055 0,08888578 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04024055 0,08880548 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04024055 0,08872533 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04024055 0,08864533 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04024055 0,08856547 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04024055 0,08848575 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04024055 0,08840618 ! meiotic prophase I GO:0007128 14 8 0,000 0,04024055 0,08832675 ! response to zinc ion GO:0010043 12 8 0,000 0,04024055 0,08824746 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,04024055 0,08816831 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04024055 0,08808931 ! oligopeptide transport GO:0006857 16 8 0,000 0,04024055 0,08801045 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04024055 0,08793173 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04024055 0,08785315 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04024055 0,08777471 ! signal peptide processing GO:0006465 12 8 0,000 0,04024055 0,08769641 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04024055 0,08761825 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04024055 0,08754022 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04024055 0,08746234 ! succinate metabolic process GO:0006105 17 8 0,000 0,04024055 0,0873846 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04024055 0,08730699 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04024055 0,08722952 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04024055 0,08715219 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04024055 0,087075 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04024055 0,08699794 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04024055 0,08692102 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04024055 0,08684423 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04024055 0,08676758 ! reflex GO:0060004 17 8 0,000 0,04024055 0,08669107 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04024055 0,08661469 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04024055 0,08653844 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04024055 0,08646233 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04024055 0,08638635 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04024055 0,08631051 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04024055 0,0862348 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04024055 0,08615922 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04024055 0,08608377 ! histidine catabolic process GO:0006548 10 8 0,000 0,04024055 0,08600846 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04024055 0,08593328 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04024055 0,08585823 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04024055 0,08578331 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04024055 0,08570852 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04024055 0,08563386 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04024055 0,08555933 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04024055 0,08548493 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04024055 0,08541066 ! macrophage activation GO:0042116 13 8 0,000 0,04024055 0,08533652 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04024055 0,08526251 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04024055 0,08518862 ! purine salvage GO:0043101 12 8 0,000 0,04024055 0,08511487 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04024055 0,08504124 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04024055 0,08496774 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04024055 0,08489436 ! osteoblast development GO:0002076 17 8 0,000 0,04024055 0,08482111 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04024055 0,08474799 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04024055 0,084675 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04024055 0,08460213 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04024055 0,08452938 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04024055 0,08445676 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04024055 0,08438427 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04024055 0,0843119 ! intermediate filament organization GO:0045109 12 8 0,000 0,04024055 0,08423965 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04024055 0,08416753 ! cellular extravasation GO:0045123 13 8 0,000 0,04024055 0,08409553 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04024055 0,08402365 ! response to antibiotic GO:0046677 11 8 0,000 0,04024055 0,0839519 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04024055 0,08388027 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04024055 0,08380876 ! DNA topological change GO:0006265 12 8 0,000 0,04024055 0,08373737 ! response to tropane GO:0014073 15 8 0,000 0,04024055 0,0836661 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04024055 0,08359496 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04024055 0,08352393 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04024055 0,08345303 ! mast cell activation GO:0045576 14 8 0,000 0,04024055 0,08338225 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04024055 0,08331159 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04024055 0,08324104 ! gas homeostasis GO:0033483 14 8 0,000 0,04024055 0,08317062 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04024055 0,08310031 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04024055 0,08303013 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04024055 0,08296006 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04024055 0,08289011 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04024055 0,08282028 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04024055 0,08275056 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04024055 0,08268097 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04024055 0,08261149 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04024055 0,08254213 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04024055 0,08247288 ! response to tumor cell GO:0002347 16 8 0,000 0,04024055 0,08240375 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04024055 0,08233473 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04024055 0,08226583 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04024055 0,08219705 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04024055 0,08212838 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04024055 0,08205983 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04024055 0,08199139 ! hormone catabolic process GO:0042447 17 8 0,000 0,04024055 0,08192306 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04024055 0,08185485 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04024055 0,08178675 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04024055 0,08171876 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04024055 0,08165089 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04024055 0,08158313 ! adult feeding behavior GO:0008343 10 8 0,000 0,04024055 0,08151548 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04024055 0,08144795 ! ATP catabolic process GO:0006200 11 8 0,000 0,04024055 0,08138052 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04024055 0,08131321 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04024055 0,08124601 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04024055 0,08117892 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04024055 0,08111194 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04024055 0,08104507 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04024055 0,08097831 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04024055 0,08091166 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04024055 0,08084512 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04024055 0,08077869 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04024055 0,08071237 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04024055 0,08064616 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04024055 0,08058006 ! protein prenylation GO:0018342 21 8 0,000 0,04024055 0,08051406 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04024055 0,08044818 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04024055 0,0803824 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04024055 0,08031672 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04024055 0,08025116 ! viral reproductive process GO:0022415 132 62 1,000 0,04035136 0,08040651 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,04035136 0,08034098 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,04153713 0,08263454 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,04394754 0,0873587 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,04394754 0,08728768 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,04394754 0,08721677 GO:0048609|reproductive process in a multicellular organism, ! axon extension GO:0048675 16 9 0,000 0,04515603 0,08954235 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04515603 0,08946972 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04515603 0,08939722 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04515603 0,08932483 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,04515603 0,08925256 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,04515603 0,08918041 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,04515603 0,08910838 ! reproductive behavior GO:0019098 22 9 0,000 0,04515603 0,08903646 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04515603 0,08896465 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,04515603 0,08889297 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04515603 0,08882139 ! UTP metabolic process GO:0046051 10 9 0,000 0,04515603 0,08874994 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,04515603 0,08867859 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,04515603 0,08860737 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04515603 0,08853625 ! artery development GO:0060840 25 9 0,000 0,04515603 0,08846525 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,04515603 0,08839437 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,04515603 0,08832359 ! equilibrioception GO:0050957 20 9 0,000 0,04515603 0,08825294 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,04515603 0,08818239 ! chemosensory behavior GO:0007635 21 9 0,000 0,04515603 0,08811196 ! microtubule bundle formation GO:0001578 22 9 0,000 0,04515603 0,08804164 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,04515603 0,08797143 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04515603 0,08790133 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,04515603 0,08783135 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04515603 0,08776147 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04515603 0,08769171 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,04515603 0,08762206 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04515603 0,08755252 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04515603 0,08748308 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04515603 0,08741376 ! protein targeting to ER GO:0045047 25 9 0,000 0,04515603 0,08734455 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04515603 0,08727545 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,04515603 0,08720646 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,04515603 0,08713757 ! glycine catabolic process GO:0006546 15 9 0,000 0,04515603 0,0870688 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04515603 0,08700013 ! endosome organization GO:0007032 20 9 0,000 0,04515603 0,08693158 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04515603 0,08686313 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04515603 0,08679478 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04515603 0,08672655 ! mannose metabolic process GO:0006013 13 9 0,000 0,04515603 0,08665842 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04515603 0,0865904 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04515603 0,08652249 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,04515603 0,08645468 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04515603 0,08638698 ! receptor clustering GO:0043113 20 9 0,000 0,04515603 0,08631938 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04515603 0,08625189 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04515603 0,08618451 ! retinol metabolic process GO:0042572 20 9 0,000 0,04515603 0,08611723 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04515603 0,08605005 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04515603 0,08598298 GO:0007351|tripartite regional subdivision, ! macrophage differentiation GO:0030225 15 9 0,000 0,04515603 0,08591602 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04515603 0,08584916 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,04515603 0,0857824 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04515603 0,08571575 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04515603 0,0856492 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04515603 0,08558275 ! response to amine stimulus GO:0014075 13 9 0,000 0,04515603 0,08551641 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04515603 0,08545017 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04515603 0,08538403 ! erythrocyte development GO:0048821 17 9 0,000 0,04515603 0,085318 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04515603 0,08525206 ! renal water homeostasis GO:0003091 15 9 0,000 0,04515603 0,08518623 ! postreplication repair GO:0006301 25 9 0,000 0,04515603 0,0851205 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04515603 0,08505487 ! icosanoid secretion GO:0032309 15 9 0,000 0,04515603 0,08498934 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04515603 0,08492392 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,04515603 0,08485859 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04515603 0,08479337 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04515603 0,08472824 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04515603 0,08466322 ! sterol catabolic process GO:0016127 14 9 0,000 0,04515603 0,08459829 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04515603 0,08453346 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04515603 0,08446874 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,04515603 0,08440411 ! S phase GO:0051320 10 9 0,000 0,04515603 0,08433958 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,04515603 0,08427515 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,04515603 0,08421082 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,04515603 0,08414658 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04515603 0,08408245 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04515603 0,08401841 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04515603 0,08395447 ! purine base metabolic process GO:0006144 25 9 0,000 0,04515603 0,08389062 ! pigment granule transport GO:0051904 17 9 0,000 0,04515603 0,08382688 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,04515603 0,08376323 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04515603 0,08369967 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04515603 0,08363622 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04515603 0,08357286 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,04515603 0,08350959 ! mitochondrion localization GO:0051646 18 9 0,000 0,04515603 0,08344642 ! regulation of cytokine biosynthetic process GO:0042035 108 66 1,000 0,04517186 0,08341259 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,04640871 0,08563178 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 1,000 0,04640871 0,08556715 ! secondary metabolic process GO:0019748 125 67 1,000 0,04640871 0,08550262 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,04765793 0,08773799 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,04765793 0,08767192 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,04765793 0,08760595 ! viral reproduction GO:0016032 142 68 1,000 0,04765793 0,08754009 ! adaptive immune response GO:0002250 126 68 1,000 0,04765793 0,08747432 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,04765793 0,08740864 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,04891936 0,0896549 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,04891936 0,0895877 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,04891936 0,08952059 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,05004646 0,0915146 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05004646 0,09144615 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05004646 0,0913778 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05004646 0,09130956 ! associative learning GO:0008306 21 10 0,000 0,05004646 0,09124142 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05004646 0,09117338 ! phosphate transport GO:0006817 24 10 0,000 0,05004646 0,09110544 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05004646 0,0910376 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,05004646 0,09096987 ! CTP metabolic process GO:0046036 11 10 0,000 0,05004646 0,09090223 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,05004646 0,0908347 ! GTP metabolic process GO:0046039 11 10 0,000 0,05004646 0,09076726 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05004646 0,09069993 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05004646 0,09063269 ! social behavior GO:0035176 29 10 0,000 0,05004646 0,09056556 ! smoothened signaling pathway GO:0007224 18 10 0,000 0,05004646 0,09049852 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,05004646 0,09043158 ! androgen metabolic process GO:0008209 17 10 0,000 0,05004646 0,09036475 ! phospholipid efflux GO:0033700 19 10 0,000 0,05004646 0,09029801 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05004646 0,09023137 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05004646 0,09016482 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,05004646 0,09009838 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,05004646 0,09003203 ! lung alveolus development GO:0048286 26 10 0,000 0,05004646 0,08996579 ! pathogenesis GO:0009405 17 10 0,000 0,05004646 0,08989963 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05004646 0,08983358 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,05004646 0,08976762 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05004646 0,08970176 ! endoderm development GO:0007492 18 10 0,000 0,05004646 0,089636 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,05004646 0,08957033 ! arginine catabolic process GO:0006527 17 10 0,000 0,05004646 0,08950476 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05004646 0,08943928 ! proline metabolic process GO:0006560 13 10 0,000 0,05004646 0,0893739 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05004646 0,08930862 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,05004646 0,08924343 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05004646 0,08917834 ! V(D)J recombination GO:0033151 34 10 0,000 0,05004646 0,08911334 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05004646 0,08904844 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,05004646 0,08898363 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05004646 0,08891891 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,05004646 0,08885429 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05004646 0,08878976 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05004646 0,08872533 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,05004646 0,08866099 ! ruffle organization GO:0031529 17 10 0,000 0,05004646 0,08859674 ! epithelial cell development GO:0002064 21 10 0,000 0,05004646 0,08853259 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05004646 0,08846853 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05004646 0,08840456 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05004646 0,08834068 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05004646 0,0882769 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,05004646 0,0882132 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05004646 0,0881496 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,05004646 0,0880861 ! regulation of bone resorption GO:0045124 25 10 0,000 0,05004646 0,08802268 ! brain morphogenesis GO:0048854 23 10 0,000 0,05004646 0,08795935 ! segment specification GO:0007379 15 10 0,000 0,05004646 0,08789612 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,05004646 0,08783298 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,05004646 0,08776992 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05004646 0,08770696 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05004646 0,08764409 ! response to dsRNA GO:0043331 23 10 0,000 0,05004646 0,08758131 ! DNA ligation GO:0006266 18 10 0,000 0,05004646 0,08751861 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,05004646 0,08745601 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05004646 0,0873935 ! melanosome localization GO:0032400 16 10 0,000 0,05004646 0,08733107 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05004646 0,08726874 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05004646 0,08720649 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05004646 0,08714433 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,05004646 0,08708227 ! induction of an organ GO:0001759 17 10 0,000 0,05004646 0,08702029 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05004646 0,08695839 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05004646 0,08689659 ! protein sumoylation GO:0016925 17 10 0,000 0,05004646 0,08683487 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,05004646 0,08677324 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05004646 0,0867117 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05004646 0,08665025 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05004646 0,08658888 ! salivary gland development GO:0007431 28 10 0,000 0,05004646 0,0865276 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05004646 0,08646641 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,05004646 0,0864053 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05004646 0,08634428 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,05004646 0,08628335 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05004646 0,0862225 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,05004646 0,08616174 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05004646 0,08610106 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05004646 0,08604047 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05004646 0,08597996 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05004646 0,08591954 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,05004646 0,0858592 ! detection of calcium ion GO:0005513 24 10 0,000 0,05004646 0,08579895 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05004646 0,08573878 ! blastocyst formation GO:0001825 18 10 0,000 0,05004646 0,0856787 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05004646 0,0856187 ! cerebellar cortex development GO:0021695 16 10 0,000 0,05004646 0,08555878 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,05004646 0,08549895 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,05004646 0,0854392 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,05004646 0,08537954 ! activation of immune response GO:0002253 120 70 1,000 0,05019284 0,08556951 ! appendage morphogenesis GO:0035107 150 72 1,000 0,05277536 0,08990949 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 1,000 0,05277536 0,08984683 ! B cell activation GO:0042113 179 72 1,000 0,05277536 0,08978426 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,05277536 0,08972178 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,05277536 0,08965939 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,05277536 0,08959708 ! appendage development GO:0048736 151 73 1,000 0,05408409 0,09175516 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 1,000 0,05408409 0,09169148 ! regulation of immune effector process GO:0002697 156 73 1,000 0,05408409 0,0916279 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,05491198 0,09296603 ! respiratory burst GO:0045730 17 11 0,000 0,05491198 0,09290165 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05491198 0,09283736 ! neuron fate specification GO:0048665 18 11 0,000 0,05491198 0,09277315 ! telencephalon cell migration GO:0022029 23 11 0,000 0,05491198 0,09270904 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,05491198 0,09264501 ! thyroid gland development GO:0030878 26 11 0,000 0,05491198 0,09258108 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,05491198 0,09251723 ! synapsis GO:0007129 14 11 0,000 0,05491198 0,09245347 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05491198 0,09238979 ! response to pain GO:0048265 27 11 0,000 0,05491198 0,09232621 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05491198 0,09226271 ! blood vessel remodeling GO:0001974 30 11 0,000 0,05491198 0,0921993 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,05491198 0,09213597 ! bone resorption GO:0045453 16 11 0,000 0,05491198 0,09207274 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05491198 0,09200959 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05491198 0,09194652 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05491198 0,09188355 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05491198 0,09182066 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05491198 0,09175785 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05491198 0,09169513 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05491198 0,0916325 GO:0010833|telomere maintenance via telomere lengthening, ! regulation of intracellular pH GO:0051453 21 11 0,000 0,05491198 0,09156995 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05491198 0,09150749 ! UV protection GO:0009650 20 11 0,000 0,05491198 0,09144511 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,05491198 0,09138282 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05491198 0,09132061 ! macroautophagy GO:0016236 19 11 0,000 0,05491198 0,09125849 ! temperature homeostasis GO:0001659 18 11 0,000 0,05491198 0,09119645 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05491198 0,0911345 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,05491198 0,09107263 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05491198 0,09101084 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,05491198 0,09094914 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,05491198 0,09088752 ! regulation of organ growth GO:0046620 14 11 0,000 0,05491198 0,09082598 ! pigment granule localization GO:0051875 20 11 0,000 0,05491198 0,09076453 ! vasoconstriction GO:0042310 20 11 0,000 0,05491198 0,09070316 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05491198 0,09064188 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05491198 0,09058067 ! embryonic axis specification GO:0000578 19 11 0,000 0,05491198 0,09051955 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05491198 0,09045852 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05491198 0,09039756 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05491198 0,09033669 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05491198 0,09027589 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05491198 0,09021518 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05491198 0,09015456 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05491198 0,09009401 ! prophase GO:0051324 17 11 0,000 0,05491198 0,09003354 ! nucleosome positioning GO:0016584 15 11 0,000 0,05491198 0,08997316 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05491198 0,08991285 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05491198 0,08985263 ! apical protein localization GO:0045176 18 11 0,000 0,05491198 0,08979249 ! acid secretion GO:0046717 20 11 0,000 0,05491198 0,08973243 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05491198 0,08967245 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05491198 0,08961254 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,05491198 0,08955272 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05491198 0,08949298 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,05491198 0,08943332 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05491198 0,08937374 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,05491198 0,08931423 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05491198 0,08925481 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,05491198 0,08919546 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,05491198 0,0891362 ! embryonic gut development GO:0048566 19 11 0,000 0,05491198 0,08907701 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,05491198 0,0890179 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05491198 0,08895887 ! activation of innate immune response GO:0002218 16 11 0,000 0,05491198 0,08889992 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05491198 0,08884105 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05491198 0,08878225 ! lysogeny GO:0030069 22 11 0,000 0,05491198 0,08872353 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05491198 0,08866489 ! sequestering of metal ion GO:0051238 15 11 0,000 0,05491198 0,08860633 ! nucleus localization GO:0051647 22 11 0,000 0,05491198 0,08854784 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,05540426 0,08928272 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,05673572 0,09136808 ! axon guidance GO:0007411 162 75 1,000 0,05673572 0,09130789 ! rhythmic process GO:0048511 142 75 1,000 0,05673572 0,09124778 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 1,000 0,05807833 0,09334563 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,05943194 0,0954584 ! cytosolic calcium ion homeostasis GO:0051480 149 77 1,000 0,05943194 0,09539568 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,05943194 0,09533304 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,05975272 0,09578472 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,05975272 0,09572191 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,05975272 0,09565918 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,05975272 0,09559653 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,05975272 0,09553397 ! protein complex disassembly GO:0043241 28 12 0,000 0,05975272 0,09547149 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05975272 0,09540909 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,05975272 0,09534677 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,05975272 0,09528453 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,05975272 0,09522238 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,05975272 0,0951603 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,05975272 0,09509831 ! ventral spinal cord development GO:0021517 25 12 0,000 0,05975272 0,0950364 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,05975272 0,09497456 ! drug transport GO:0015893 16 12 0,000 0,05975272 0,09491281 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,05975272 0,09485114 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,05975272 0,09478955 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,05975272 0,09472804 ! polyamine metabolic process GO:0006595 18 12 0,000 0,05975272 0,09466661 ! mitotic spindle organization GO:0007052 23 12 0,000 0,05975272 0,09460525 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,05975272 0,09454398 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,05975272 0,09448279 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,05975272 0,09442167 ! lipid digestion GO:0044241 21 12 0,000 0,05975272 0,09436064 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,05975272 0,09429968 ! entry into host cell GO:0030260 34 12 0,000 0,05975272 0,0942388 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05975272 0,094178 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,05975272 0,09411728 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,05975272 0,09405664 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05975272 0,09399608 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,05975272 0,09393559 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,05975272 0,09387518 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,05975272 0,09381485 ! snRNA metabolic process GO:0016073 30 12 0,000 0,05975272 0,0937546 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,05975272 0,09369442 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,05975272 0,09363432 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05975272 0,0935743 ! cranial nerve development GO:0021545 23 12 0,000 0,05975272 0,09351435 ! fucose catabolic process GO:0019317 25 12 0,000 0,05975272 0,09345449 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,05975272 0,09339469 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,05975272 0,09333498 ! autonomic nervous system development GO:0048483 24 12 0,000 0,05975272 0,09327534 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,05975272 0,09321578 ! zymogen activation GO:0031638 18 12 0,000 0,05975272 0,09315629 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,05975272 0,09309688 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,05975272 0,09303754 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,05975272 0,09297828 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,05975272 0,0929191 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,05975272 0,09285999 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,05975272 0,09280096 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,05975272 0,092742 ! defense response to fungus GO:0050832 15 12 0,000 0,05975272 0,09268312 ! developmental induction GO:0031128 22 12 0,000 0,05975272 0,09262431 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,05975272 0,09256557 ! lamellipodium assembly GO:0030032 24 12 0,000 0,05975272 0,09250691 ! establishment of cell polarity GO:0030010 21 12 0,000 0,05975272 0,09244833 ! regulation of synapse organization GO:0050807 18 12 0,000 0,05975272 0,09238981 ! localization within membrane GO:0051668 26 12 0,000 0,05975272 0,09233138 ! antigen processing and presentation GO:0019882 117 78 1,000 0,06079639 0,0938847 ! protein oligomerization GO:0051259 149 79 1,000 0,06217155 0,09594764 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,06355728 0,09802426 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,06456881 0,09952151 ! cGMP metabolic process GO:0046068 18 13 0,000 0,06456881 0,09945876 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,06456881 0,09939609 ! regulation of chemokine production GO:0032642 18 13 0,000 0,06456881 0,0993335 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,06456881 0,09927098 ! peroxisomal transport GO:0043574 28 13 0,000 0,06456881 0,09920855 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,06456881 0,09914619 ! cartilage condensation GO:0001502 22 13 0,000 0,06456881 0,09908392 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,06456881 0,09902172 ! organelle fusion GO:0048284 36 13 0,000 0,06456881 0,09895959 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,06456881 0,09889755 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,06456881 0,09883558 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,06456881 0,0987737 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,06456881 0,09871189 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,06456881 0,09865015 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,06456881 0,0985885 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,06456881 0,09852692 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,06456881 0,09846541 ! methionine metabolic process GO:0006555 31 13 0,000 0,06456881 0,09840399 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,06456881 0,09834264 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,06456881 0,09828137 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,06456881 0,09822017 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,06456881 0,09815905 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,06456881 0,09809801 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,06456881 0,09803704 ! exocrine system development GO:0035272 34 13 0,000 0,06456881 0,09797614 ! asymmetric protein localization GO:0008105 24 13 0,000 0,06456881 0,09791533 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,06456881 0,09785459 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,06456881 0,09779392 ! L-glutamate transport GO:0015813 30 13 0,000 0,06456881 0,09773333 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,06456881 0,09767281 ! protein homotetramerization GO:0051289 24 13 0,000 0,06456881 0,09761237 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,06456881 0,09755201 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,06456881 0,09749171 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,06456881 0,0974315 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,06456881 0,09737135 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,06456881 0,09731129 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,06456881 0,09725129 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,06456881 0,09719137 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,06456881 0,09713152 ! histone methylation GO:0016571 29 13 0,000 0,06456881 0,09707175 ! chromatin silencing GO:0006342 29 13 0,000 0,06456881 0,09701205 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,06456881 0,09695242 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,06456881 0,09689287 ! regulation of epidermis development GO:0045682 19 13 0,000 0,06456881 0,09683339 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,06456881 0,09677398 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,06456881 0,09671465 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,06456881 0,09665539 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,06456881 0,0965962 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,06456881 0,09653708 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,06456881 0,09647804 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,06456881 0,09641907 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,06456881 0,09636017 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,06456881 0,09630134 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,06456881 0,09624258 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,06456881 0,0961839 ! insulin secretion GO:0030073 24 13 0,000 0,06456881 0,09612529 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,06456881 0,09606674 ! acrosome reaction GO:0007340 19 13 0,000 0,06456881 0,09600827 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,06456881 0,09594987 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,06456881 0,09589155 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,06495342 0,09640413 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,06777639 0,10053292 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,06777639 0,10047192 GO:0045937|positive regulation of phosphate metabolic process, ! rRNA transcription GO:0009303 28 14 0,000 0,06936035 0,10275764 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,06936035 0,10269536 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,06936035 0,10263316 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,06936035 0,10257103 ! non-recombinational repair GO:0000726 29 14 0,000 0,06936035 0,10250898 GO:0006303|double-strand break repair via nonhomologous end joining, ! retina development in camera-type eye GO:0060041 28 14 0,000 0,06936035 0,102447 ! RNA polyadenylation GO:0043631 32 14 0,000 0,06936035 0,1023851 ! lipid localization GO:0010876 32 14 0,000 0,06936035 0,10232328 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,06936035 0,10226152 ! regulated secretory pathway GO:0045055 24 14 0,000 0,06936035 0,10219985 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,06936035 0,10213824 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,06936035 0,10207671 ! arginine metabolic process GO:0006525 21 14 0,000 0,06936035 0,10201526 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,06936035 0,10195388 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,06936035 0,10189257 ! regulation of heart rate GO:0002027 25 14 0,000 0,06936035 0,10183134 ! organic alcohol transport GO:0015850 29 14 0,000 0,06936035 0,10177018 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,06936035 0,10170909 ! embryo implantation GO:0007566 30 14 0,000 0,06936035 0,10164808 ! neutral amino acid transport GO:0015804 28 14 0,000 0,06936035 0,10158714 ! bone mineralization GO:0030282 18 14 0,000 0,06936035 0,10152627 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,06936035 0,10146548 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,06936035 0,10140475 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,06936035 0,10134411 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,06936035 0,10128353 ! regulation of cellular pH GO:0030641 27 14 0,000 0,06936035 0,10122302 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,06936035 0,10116259 ! ribosome assembly GO:0042255 18 14 0,000 0,06936035 0,10110223 ! cerebellum development GO:0021549 23 14 0,000 0,06936035 0,10104195 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,06936035 0,10098173 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,06936035 0,10092159 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,06936035 0,10086151 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,06936035 0,10080151 ! NADP metabolic process GO:0006739 24 14 0,000 0,06936035 0,10074158 ! oxygen transport GO:0015671 22 14 0,000 0,06936035 0,10068173 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,06936035 0,10062194 ! male genitalia development GO:0030539 26 14 0,000 0,06936035 0,10056222 ! regulation of RNA stability GO:0043487 33 14 0,000 0,06936035 0,10050258 ! regulation of axon extension GO:0030516 43 14 0,000 0,06936035 0,100443 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,06936035 0,1003835 ! negative regulation of transport GO:0051051 164 85 1,000 0,07063935 0,10217403 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,07063935 0,10211357 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,07208548 0,10414242 ! regulation of lyase activity GO:0051339 169 86 1,000 0,07208548 0,10408087 ! lactation GO:0007595 30 15 0,000 0,07412749 0,10696601 ! reproductive cellular process GO:0048610 22 15 0,000 0,07412749 0,10690287 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,07412749 0,1068398 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,07412749 0,10677681 ! superoxide anion generation GO:0042554 22 15 0,000 0,07412749 0,10671388 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,07412749 0,10665104 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,07412749 0,10658826 ! copper ion transport GO:0006825 22 15 0,000 0,07412749 0,10652557 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,07412749 0,10646294 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,07412749 0,10640039 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,07412749 0,10633791 ! sulfate transport GO:0008272 27 15 0,000 0,07412749 0,10627551 ! response to cAMP GO:0051591 25 15 0,000 0,07412749 0,10621317 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,07412749 0,10615092 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,07412749 0,10608873 ! response to hexose stimulus GO:0009746 25 15 0,000 0,07412749 0,10602662 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,07412749 0,10596458 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,07412749 0,10590261 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,07412749 0,10584071 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,07412749 0,10577889 ! regulation of exocytosis GO:0017157 26 15 0,000 0,07412749 0,10571714 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,07412749 0,10565546 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,07412749 0,10559386 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,07412749 0,10553232 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,07412749 0,10547086 ! regulation of vasodilation GO:0042312 27 15 0,000 0,07412749 0,10540947 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,07412749 0,10534815 ! water homeostasis GO:0030104 28 15 0,000 0,07412749 0,1052869 ! cofactor transport GO:0051181 30 15 0,000 0,07412749 0,10522572 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,07412749 0,10516461 ! muscle maintenance GO:0046716 26 15 0,000 0,07412749 0,10510358 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,07412749 0,10504261 ! intestinal absorption GO:0050892 31 15 0,000 0,07412749 0,10498172 ! dopamine metabolic process GO:0042417 35 15 0,000 0,07412749 0,10492089 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,07412749 0,10486014 ! heme biosynthetic process GO:0006783 33 15 0,000 0,07412749 0,10479946 ! cell killing GO:0001906 32 15 0,000 0,07412749 0,10473884 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,07412749 0,1046783 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,07412749 0,10461783 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,07412749 0,10455743 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,07412749 0,10449709 ! actin filament polymerization GO:0030041 27 15 0,000 0,07412749 0,10443683 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,07412749 0,10437664 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,07648085 0,1076283 ! tube morphogenesis GO:0035239 194 89 1,000 0,07648085 0,10756633 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,07796452 0,10958995 ! response to unfolded protein GO:0006986 139 90 1,000 0,07796452 0,10952693 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,07887034 0,11073578 ! positive regulation of cell size GO:0045793 29 16 0,000 0,07887034 0,11067217 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,07887034 0,11060864 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,07887034 0,11054518 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,07887034 0,11048179 ! bone remodeling GO:0046849 28 16 0,000 0,07887034 0,11041848 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07887034 0,11035524 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,07887034 0,11029207 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,07887034 0,11022898 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,07887034 0,11016595 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,07887034 0,110103 ! startle response GO:0001964 28 16 0,000 0,07887034 0,11004012 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,07887034 0,10997731 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,07887034 0,10991458 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,07887034 0,10985191 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,07887034 0,10978932 ! protein polyubiquitination GO:0000209 41 16 0,000 0,07887034 0,10972679 ! glutamate metabolic process GO:0006536 25 16 0,000 0,07887034 0,10966434 ! response to osmotic stress GO:0006970 27 16 0,000 0,07887034 0,10960196 ! lysosomal transport GO:0007041 31 16 0,000 0,07887034 0,10953965 ! fructose metabolic process GO:0006000 25 16 0,000 0,07887034 0,10947741 ! L-amino acid transport GO:0015807 33 16 0,000 0,07887034 0,10941525 ! stem cell development GO:0048864 46 16 0,000 0,07887034 0,10935315 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,07887034 0,10929112 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,07887034 0,10922917 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,07887034 0,10916728 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,07887034 0,10910546 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,07887034 0,10904372 ! DNA replication initiation GO:0006270 28 16 0,000 0,07887034 0,10898204 ! neuron recognition GO:0008038 40 16 0,000 0,07887034 0,10892044 ! mRNA splice site selection GO:0006376 44 16 0,000 0,07887034 0,1088589 ! tissue regeneration GO:0042246 27 16 0,000 0,07887034 0,10879743 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,07887034 0,10873603 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,07887034 0,1086747 ! biomineral formation GO:0031214 22 16 0,000 0,07887034 0,10861344 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,07887034 0,10855225 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,07887034 0,10849113 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,07887034 0,10843008 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,07887034 0,10836909 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,07887034 0,10830818 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,07887034 0,10824733 ! peptide hormone processing GO:0016486 27 16 0,000 0,07887034 0,10818655 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,07945725 0,10893044 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,08246933 0,1129964 GO:0010498|proteasomal protein catabolic process, ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,08358903 0,11446637 ! signal complex assembly GO:0007172 47 17 0,000 0,08358903 0,11440225 ! filopodium assembly GO:0046847 42 17 0,000 0,08358903 0,11433819 ! endothelial cell migration GO:0043542 31 17 0,000 0,08358903 0,11427421 ! gene silencing by RNA GO:0031047 38 17 0,000 0,08358903 0,1142103 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,08358903 0,11414646 ! glial cell development GO:0021782 28 17 0,000 0,08358903 0,11408269 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,08358903 0,11401899 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,08358903 0,11395536 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,08358903 0,11389181 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,08358903 0,11382832 ! myoblast differentiation GO:0045445 50 17 0,000 0,08358903 0,11376491 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,08358903 0,11370156 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,08358903 0,11363829 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,08358903 0,11357509 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,08358903 0,11351196 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,08358903 0,11344889 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,08358903 0,1133859 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,08358903 0,11332298 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,08358903 0,11326013 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,08358903 0,11319734 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,08358903 0,11313463 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,08358903 0,11307199 ! genitalia development GO:0048806 32 17 0,000 0,08358903 0,11300941 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,08358903 0,11294691 ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,08358903 0,11288447 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,08358903 0,1128221 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,08358903 0,11275981 ! steroid catabolic process GO:0006706 34 17 0,000 0,08358903 0,11269758 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,08358903 0,11263542 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,08358903 0,11257332 ! gas transport GO:0015669 26 17 0,000 0,08358903 0,1125113 ! organic cation transport GO:0015695 32 17 0,000 0,08358903 0,11244934 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,08358903 0,11238746 ! female pregnancy GO:0007565 166 94 1,000 0,08398844 0,11286235 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,08551608 0,114852 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,08551608 0,11478889 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,08828368 0,11843879 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,08828368 0,11837378 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,08828368 0,11830885 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,08828368 0,11824399 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,08828368 0,1181792 ! adult walking behavior GO:0007628 36 18 0,000 0,08828368 0,11811448 ! patterning of blood vessels GO:0001569 43 18 0,000 0,08828368 0,11804983 ! heart looping GO:0001947 34 18 0,000 0,08828368 0,11798525 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,08828368 0,11792074 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,08828368 0,1178563 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,08828368 0,11779194 ! glycine metabolic process GO:0006544 30 18 0,000 0,08828368 0,11772764 ! glutamine metabolic process GO:0006541 29 18 0,000 0,08828368 0,11766341 ! response to retinoic acid GO:0032526 31 18 0,000 0,08828368 0,11759926 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,08828368 0,11753517 ! DNA integration GO:0015074 32 18 0,000 0,08828368 0,11747115 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,08828368 0,11740721 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,08828368 0,11734333 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,08828368 0,11727952 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,08828368 0,11721578 ! neural crest cell migration GO:0001755 41 18 0,000 0,08828368 0,11715211 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,08828368 0,11708851 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,08828368 0,11702498 GO:0046466|membrane lipid catabolic process, ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,08828368 0,11696152 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,08828368 0,11689812 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,08828368 0,1168348 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,08828368 0,11677154 ! detection of bacterium GO:0016045 22 18 0,000 0,08828368 0,11670835 ! nerve development GO:0021675 34 18 0,000 0,08828368 0,11664523 ! microspike assembly GO:0030035 46 18 0,000 0,08828368 0,11658218 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,08828368 0,1165192 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,08828368 0,11645628 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,09014898 0,11885265 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,09295441 0,12248524 ! positive regulation of translation GO:0045727 31 19 0,000 0,09295441 0,12241921 ! negative regulation of defense response GO:0031348 27 19 0,000 0,09295441 0,12235325 ! neuron maturation GO:0042551 46 19 0,000 0,09295441 0,12228736 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,09295441 0,12222154 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,09295441 0,1221558 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,09295441 0,12209012 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,09295441 0,12202452 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,09295441 0,12195899 ! inositol metabolic process GO:0006020 33 19 0,000 0,09295441 0,12189352 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,09295441 0,12182813 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,09295441 0,1217628 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,09295441 0,12169755 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,09295441 0,12163237 ! cerebral cortex development GO:0021987 40 19 0,000 0,09295441 0,12156725 ! pigmentation during development GO:0048066 42 19 0,000 0,09295441 0,12150221 ! response to vitamin A GO:0033189 32 19 0,000 0,09295441 0,12143724 ! heme metabolic process GO:0042168 40 19 0,000 0,09295441 0,12137233 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,09295441 0,12130749 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,09295441 0,12124273 ! response to fungus GO:0009620 26 19 0,000 0,09295441 0,12117803 ! peptide cross-linking GO:0018149 39 19 0,000 0,09295441 0,1211134 ! protein export from nucleus GO:0006611 40 19 0,000 0,09295441 0,12104884 ! heart process GO:0003015 32 19 0,000 0,09295441 0,12098435 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,09295441 0,12091993 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,09295441 0,12085558 ! visual learning GO:0008542 38 19 0,000 0,09295441 0,12079129 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,09295441 0,12072708 ! vitamin transport GO:0051180 31 19 0,000 0,09295441 0,12066293 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,09295441 0,12059885 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,09295441 0,12053484 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,09295441 0,12047089 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,09295441 0,12040702 ! cilium assembly GO:0042384 38 19 0,000 0,09295441 0,12034321 ! peptide hormone secretion GO:0030072 32 19 0,000 0,09295441 0,12027947 ! positive regulation of immune response GO:0050778 175 100 1,000 0,09327799 0,12063427 ! protein secretion GO:0009306 45 20 0,000 0,09760135 0,12615878 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,09760135 0,12609206 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,09760135 0,12602542 ! positive regulation of ossification GO:0045778 50 20 0,000 0,09760135 0,12595884 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,09760135 0,12589234 ! skin development GO:0043588 42 20 0,000 0,09760135 0,1258259 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,09760135 0,12575954 ! response to vitamin GO:0033273 36 20 0,000 0,09760135 0,12569325 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,09760135 0,12562702 ! bile acid metabolic process GO:0008206 34 20 0,000 0,09760135 0,12556087 ! retinoid metabolic process GO:0001523 34 20 0,000 0,09760135 0,12549478 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,09760135 0,12542877 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,09760135 0,12536282 GO:0032392|DNA geometric change, ! body fluid secretion GO:0007589 33 20 0,000 0,09760135 0,12529695 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,09760135 0,12523114 ! peptide secretion GO:0002790 38 20 0,000 0,09760135 0,1251654 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,09760135 0,12509973 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,09760135 0,12503413 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,09760135 0,1249686 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,09760135 0,12490314 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,09760135 0,12483774 ! cell-cell junction organization GO:0045216 43 20 0,000 0,09760135 0,12477242 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,09760135 0,12470716 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,09760135 0,12464197 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,09760135 0,12457685 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,09760135 0,1245118 ! regulation of glucose import GO:0046324 30 20 0,000 0,09760135 0,12444681 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,09760135 0,12438189 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,09760135 0,12431704 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,09760135 0,12425226 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,1022246 0,13007016 ! hormone secretion GO:0046879 39 21 0,000 0,1022246 0,13000245 ! cAMP metabolic process GO:0046058 41 21 0,000 0,1022246 0,12993481 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,1022246 0,12986724 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,1022246 0,12979974 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,1022246 0,12973231 ! smooth muscle contraction GO:0006939 48 21 0,000 0,1022246 0,12966495 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,1022246 0,12959767 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,1022246 0,12953045 ! plasma membrane fusion GO:0045026 33 21 0,000 0,1022246 0,1294633 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,1022246 0,12939622 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,1022246 0,12932921 ! sensory perception of pain GO:0019233 33 21 0,000 0,1022246 0,12926227 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,1022246 0,1291954 ! collagen fibril organization GO:0030199 62 21 0,000 0,1022246 0,1291286 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,1022246 0,12906186 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,1022246 0,1289952 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,1022246 0,1289286 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,1022246 0,12886208 ! collagen catabolic process GO:0030574 29 21 0,000 0,1022246 0,12879562 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,1022246 0,12872923 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,1022246 0,12866291 ! sperm-egg recognition GO:0035036 23 21 0,000 0,1022246 0,12859665 ! actin filament-based movement GO:0030048 47 21 0,000 0,1022246 0,12853047 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,1022246 0,12846435 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,1068243 0,13417572 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,1068243 0,13410677 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,1068243 0,13403789 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,1068243 0,13396908 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,1068243 0,13390034 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,1068243 0,13383168 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,1068243 0,13376308 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,1068243 0,13369455 ! cellular response to starvation GO:0009267 37 22 0,000 0,1068243 0,1336261 ! vacuolar transport GO:0007034 41 22 0,000 0,1068243 0,13355771 ! central nervous system neuron development GO:0021954 47 22 0,000 0,1068243 0,1334894 ! fucose metabolic process GO:0006004 44 22 0,000 0,1068243 0,13342115 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,1068243 0,13335297 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,1068243 0,13328487 ! stem cell differentiation GO:0048863 57 22 0,000 0,1068243 0,13321683 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,1068243 0,13314886 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,1068243 0,13308096 ! cytolysis GO:0019835 27 22 0,000 0,1068243 0,13301313 ! vasodilation GO:0042311 40 22 0,000 0,1068243 0,13294537 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,1068243 0,13287768 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,1068243 0,13281006 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,1068243 0,13274251 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,1068243 0,13267502 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,1068243 0,13260761 ! sarcomere organization GO:0045214 32 22 0,000 0,1068243 0,13254026 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,1068243 0,13247298 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,1068243 0,13240577 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,1068243 0,13233863 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,1068243 0,13227155 ! protein stabilization GO:0050821 41 22 0,000 0,1068243 0,13220454 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,11140056 0,13779827 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,11140056 0,13772853 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,11140056 0,13765887 ! gluconeogenesis GO:0006094 38 23 0,000 0,11140056 0,13758927 ! glycerol metabolic process GO:0006071 40 23 0,000 0,11140056 0,13751975 ! viral genome replication GO:0019079 44 23 0,000 0,11140056 0,13745029 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,11140056 0,13738091 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,11140056 0,13731159 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,11140056 0,13724235 ! axis specification GO:0009798 43 23 0,000 0,11140056 0,13717317 ! visual behavior GO:0007632 46 23 0,000 0,11140056 0,13710407 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,11140056 0,13703503 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,11140056 0,13696607 ! peroxisome organization GO:0007031 43 23 0,000 0,11140056 0,13689717 ! lysosome organization GO:0007040 47 23 0,000 0,11140056 0,13682834 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,11140056 0,13675959 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,11140056 0,1366909 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,11140056 0,13662228 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,11140056 0,13655373 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,11140056 0,13648524 ! fatty acid transport GO:0015908 47 23 0,000 0,11140056 0,13641683 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,11140056 0,13634849 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,11140056 0,13628021 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,11140056 0,136212 ! hormone transport GO:0009914 41 23 0,000 0,11140056 0,13614386 ! cell-cell recognition GO:0009988 28 23 0,000 0,11140056 0,13607579 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,11140056 0,13600778 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,11140056 0,13593985 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,11140056 0,13587198 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,11595351 0,1413545 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,11595351 0,141284 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,11595351 0,14121357 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,11595351 0,14114321 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,11595351 0,14107292 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,11595351 0,1410027 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,11595351 0,14093255 ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,11595351 0,14086246 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,11595351 0,14079245 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,11595351 0,14072251 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,11595351 0,14065264 GO:0051693|actin filament capping, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,11595351 0,14058284 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,11595351 0,1405131 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,11595351 0,14044344 ! membrane depolarization GO:0051899 45 24 0,000 0,11595351 0,14037384 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,11595351 0,14030432 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,11595351 0,14023486 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,11595351 0,14016547 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,11595351 0,14009615 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,11595351 0,1400269 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,11595351 0,13995772 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,11595351 0,1398886 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,11595351 0,13981955 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,11595351 0,13975058 ! regulation of amine transport GO:0051952 41 24 0,000 0,11595351 0,13968167 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,12048325 0,14506682 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,12048325 0,14499536 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,12048325 0,14492397 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,12048325 0,14485265 ! phototransduction GO:0007602 37 25 0,000 0,12048325 0,1447814 ! keratinization GO:0031424 37 25 0,000 0,12048325 0,14471022 ! vacuole organization GO:0007033 49 25 0,000 0,12048325 0,1446391 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,12048325 0,14456806 ! receptor metabolic process GO:0043112 53 25 0,000 0,12048325 0,14449709 ! chromosome condensation GO:0030261 48 25 0,000 0,12048325 0,14442619 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,12048325 0,14435536 ! regulation of behavior GO:0050795 48 25 0,000 0,12048325 0,1442846 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,12048325 0,1442139 ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,12048325 0,14414328 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,12048325 0,14407273 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,12498991 0,14938862 ! initiation of viral infection GO:0019059 60 26 0,000 0,12498991 0,14931557 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,12498991 0,14924259 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,12498991 0,14916969 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,12498991 0,14909685 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,12498991 0,14902408 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,12498991 0,14895139 ! spinal cord development GO:0021510 54 26 0,000 0,12498991 0,14887877 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,12498991 0,14880621 ! digestive system process GO:0022600 49 26 0,000 0,12498991 0,14873373 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,12498991 0,14866132 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,12498991 0,14858898 ! osteoblast differentiation GO:0001649 63 26 0,000 0,12498991 0,14851671 ! neural crest cell development GO:0014032 59 26 0,000 0,12498991 0,14844451 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,12498991 0,14837238 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,12498991 0,14830031 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,12498991 0,14822832 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,12498991 0,1481564 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,12498991 0,14808455 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,12498991 0,14801277 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,12498991 0,14794106 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,12498991 0,14786942 ! telomere organization GO:0032200 46 26 0,000 0,12498991 0,14779785 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,12498991 0,14772634 ! neural tube closure GO:0001843 58 26 0,000 0,12498991 0,14765491 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,12498991 0,14758354 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,12498991 0,14751225 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,12498991 0,14744102 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,1294736 0,15265638 ! embryonic pattern specification GO:0009880 49 27 0,000 0,1294736 0,15258274 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,1294736 0,15250917 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,1294736 0,15243567 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,1294736 0,15236224 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,1294736 0,15228888 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,1294736 0,1522156 ! iron ion transport GO:0006826 65 27 0,000 0,1294736 0,15214238 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,1294736 0,15206924 ! superoxide metabolic process GO:0006801 41 27 0,000 0,1294736 0,15199616 ! tube lumen formation GO:0035148 59 27 0,000 0,1294736 0,15192316 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,1294736 0,15185022 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,1294736 0,15177736 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,1294736 0,15170456 ! response to starvation GO:0042594 47 27 0,000 0,1294736 0,15163184 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,1294736 0,15155918 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,1294736 0,1514866 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,13393445 0,15663085 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,13393445 0,15655591 ! vesicle docking GO:0048278 55 28 0,000 0,13393445 0,15648104 ! circadian rhythm GO:0007623 56 28 0,000 0,13393445 0,15640624 ! dendrite development GO:0016358 67 28 0,000 0,13393445 0,15633151 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,13393445 0,15625686 ! sperm motility GO:0030317 37 28 0,000 0,13393445 0,15618227 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,13393445 0,15610776 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,13393445 0,15603331 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,13393445 0,15595894 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,13393445 0,15588464 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,13393445 0,15581041 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,13393445 0,15573625 ! glutathione metabolic process GO:0006749 42 28 0,000 0,13393445 0,15566216 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,13393445 0,15558814 ! lipid oxidation GO:0034440 48 28 0,000 0,13393445 0,15551419 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,13393445 0,15544031 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,13393445 0,1553665 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,13837256 0,16043861 ! translational initiation GO:0006413 66 29 0,000 0,13837256 0,1603625 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,13837256 0,16028647 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,13837256 0,1602105 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,13837256 0,16013461 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,13837256 0,16005879 ! primary neural tube formation GO:0014020 61 29 0,000 0,13837256 0,15998304 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,13837256 0,15990736 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,13837256 0,15983175 ! synaptogenesis GO:0007416 46 29 0,000 0,13837256 0,15975622 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,13837256 0,15968076 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,13837256 0,15960536 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,14278805 0,16462067 ! phenol metabolic process GO:0018958 56 30 0,000 0,14278805 0,16454302 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,14278805 0,16446544 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,14278805 0,16438794 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,14278805 0,16431051 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,14278805 0,16423315 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,14278805 0,16415586 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,14278805 0,16407865 ! acute-phase response GO:0006953 50 30 0,000 0,14278805 0,16400151 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,14278805 0,16392444 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,14278805 0,16384744 ! myofibril assembly GO:0030239 50 30 0,000 0,14278805 0,16377052 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,14278805 0,16369367 ! determination of left/right symmetry GO:0007368 53 30 0,000 0,14278805 0,16361689 ! phospholipid transport GO:0015914 65 30 0,000 0,14278805 0,16354018 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,14278805 0,16346355 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,14278805 0,16338698 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,14278805 0,16331049 ! regulation of coagulation GO:0050818 52 30 0,000 0,14278805 0,16323407 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,14718104 0,1681774 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,14718104 0,16809877 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,14718104 0,16802022 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,14718104 0,16794174 ! regulation of innate immune response GO:0045088 57 31 0,000 0,14718104 0,16786334 ! peptide transport GO:0015833 60 31 0,000 0,14718104 0,16778501 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,14718104 0,16770675 ! detection of light stimulus GO:0009583 44 31 0,000 0,14718104 0,16762857 ! natural killer cell activation GO:0030101 50 31 0,000 0,14718104 0,16755045 ! cofactor catabolic process GO:0051187 54 31 0,000 0,14718104 0,16747241 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,14718104 0,16739445 ! eye morphogenesis GO:0048592 65 31 0,000 0,14718104 0,16731655 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,15155164 0,17220495 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,15155164 0,17212489 ! collagen metabolic process GO:0032963 49 32 0,000 0,15155164 0,17204491 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,15155164 0,171965 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,15155164 0,17188517 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,15155164 0,1718054 ! muscle cell development GO:0055001 52 32 0,000 0,15155164 0,17172572 ! mesoderm formation GO:0001707 73 32 0,000 0,15155164 0,1716461 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,15155164 0,17156656 ! BMP signaling pathway GO:0030509 71 32 0,000 0,15155164 0,1714871 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,15155164 0,17140771 ! gene silencing GO:0016458 71 32 0,000 0,15155164 0,17132839 ! regulation of pH GO:0006885 56 33 0,000 0,15589996 0,17616263 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,15589996 0,17608118 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,15589996 0,17599981 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,15589996 0,17591852 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,15589996 0,1758373 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,15589996 0,17575616 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,15589996 0,17567509 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,15589996 0,1755941 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,15589996 0,17551318 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,15589996 0,17543233 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,15589996 0,17535156 ! glial cell differentiation GO:0010001 67 34 0,000 0,16022612 0,18013456 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,16022612 0,1800517 ! cholesterol transport GO:0030301 62 34 0,000 0,16022612 0,17996892 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,16022612 0,17988621 ! spliceosome assembly GO:0000245 75 34 0,000 0,16022612 0,17980358 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,16022612 0,17972103 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,16022612 0,17963855 ! formation of primary germ layer GO:0001704 76 34 0,000 0,16022612 0,17955615 ! cell fate specification GO:0001708 56 34 0,000 0,16022612 0,17947382 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,16022612 0,17939157 ! adult locomotory behavior GO:0008344 62 34 0,000 0,16022612 0,17930939 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,16453022 0,18404182 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,16453022 0,18395759 ! negative regulation of secretion GO:0051048 68 35 0,000 0,16453022 0,18387344 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,16453022 0,18378936 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,16453022 0,18370536 ! membrane docking GO:0022406 69 35 0,000 0,16453022 0,18362144 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,16453022 0,1835376 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,16453022 0,18345383 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,16453022 0,18337013 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,16453022 0,18328652 ! ceramide metabolic process GO:0006672 72 35 0,000 0,16453022 0,18320298 ! sterol transport GO:0015918 63 35 0,000 0,16453022 0,18311951 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,16453022 0,18303613 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,16453022 0,18295282 ! placenta development GO:0001890 53 35 0,000 0,16453022 0,18286958 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,16881239 0,18754373 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,16881239 0,18745849 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,16881239 0,18737332 ! protein targeting to membrane GO:0006612 75 36 0,000 0,16881239 0,18728822 ! regulation of proteolysis GO:0030162 77 36 0,000 0,16881239 0,18720321 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,16881239 0,18711827 ! aerobic respiration GO:0009060 56 36 0,000 0,16881239 0,18703341 ! cytokine production GO:0001816 68 36 0,000 0,16881239 0,18694863 ! embryonic organ development GO:0048568 67 36 0,000 0,16881239 0,18686392 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,16881239 0,18677929 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,16881239 0,18669474 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,17307273 0,19131977 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,17307273 0,19123323 ! odontogenesis GO:0042476 74 37 0,000 0,17307273 0,19114678 ! actomyosin structure organization GO:0031032 68 37 0,000 0,17307273 0,19106041 ! tissue remodeling GO:0048771 78 37 0,000 0,17307273 0,19097411 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,17307273 0,19088789 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,17307273 0,19080175 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,17307273 0,19071569 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,17731135 0,1952983 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,17731135 0,19521029 ! organic anion transport GO:0015711 82 38 0,000 0,17731135 0,19512236 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,17731135 0,1950345 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,17731135 0,19494673 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,17731135 0,19485904 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,17731135 0,19477142 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,17731135 0,19468388 ! spermatid development GO:0007286 69 38 0,000 0,17731135 0,19459642 ! neural tube formation GO:0001841 79 38 0,000 0,17731135 0,19450904 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,18152837 0,19904569 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,18152837 0,19895639 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,18152837 0,19886718 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,18152837 0,19877804 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,18152837 0,19868898 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,18152837 0,1986 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,18152837 0,1985111 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,18572389 0,20300826 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,18572389 0,20291746 ! learning GO:0007612 82 40 0,000 0,18572389 0,20282676 ! lipid homeostasis GO:0055088 75 40 0,000 0,18572389 0,20273613 ! mismatch repair GO:0006298 58 40 0,000 0,18572389 0,20264558 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,18572389 0,20255511 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,18572389 0,20246473 ! RNA export from nucleus GO:0006405 61 41 0,000 0,18989801 0,20692277 ! mRNA catabolic process GO:0006402 79 41 0,000 0,18989801 0,20683052 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,18989801 0,20673835 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,18989801 0,20664626 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,18989801 0,20655425 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,18989801 0,20646233 ! gliogenesis GO:0042063 91 41 0,000 0,18989801 0,20637048 ! feeding behavior GO:0007631 69 41 0,000 0,18989801 0,20627872 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,18989801 0,20618704 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,18989801 0,20609545 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,18989801 0,20600393 ! spermatid differentiation GO:0048515 73 41 0,000 0,18989801 0,20591249 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,18989801 0,20582114 ! RNA modification GO:0009451 64 41 0,000 0,18989801 0,20572987 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,19405086 0,21013575 ! organic ether metabolic process GO:0018904 59 42 0,000 0,19405086 0,21004265 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,19405086 0,20994963 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,19405086 0,20985669 ! regulation of protein secretion GO:0050708 77 42 0,000 0,19405086 0,20976383 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,19405086 0,20967105 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,19818254 0,21404064 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,19818254 0,21394606 ! regulation of tube size GO:0035150 76 43 0,000 0,19818254 0,21385156 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,19818254 0,21375715 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,19818254 0,21366281 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,19818254 0,21356857 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,19818254 0,2134744 ! ion transmembrane transport GO:0034220 79 43 0,000 0,19818254 0,21338032 ! neuron migration GO:0001764 85 43 0,000 0,19818254 0,21328632 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,19818254 0,2131924 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,20229315 0,21751856 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,20229315 0,21742286 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,20229315 0,21732725 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,20229315 0,21723172 ! striated muscle contraction GO:0006941 85 44 0,000 0,20229315 0,21713627 ! phagocytosis GO:0006909 105 44 0,000 0,20229315 0,21704091 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,20229315 0,21694564 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,2063828 0,22123439 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,2063828 0,22113736 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,2063828 0,22104041 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,2063828 0,22094355 ! polyol metabolic process GO:0019751 77 45 0,000 0,2063828 0,22084677 ! maintenance of location in cell GO:0051651 101 45 0,000 0,2063828 0,22075008 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,2104516 0,22500361 ! glycolysis GO:0006096 71 46 0,000 0,2104516 0,22490519 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,2104516 0,22480685 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,2104516 0,22470859 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,21449965 0,22893082 ! positive regulation of defense response GO:0031349 88 48 0,000 0,21852707 0,23312735 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,21852707 0,23302559 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,21852707 0,23292392 ! endosome transport GO:0016197 127 48 0,000 0,21852707 0,23282234 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,21852707 0,23272085 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,21852707 0,23261944 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,21852707 0,23251813 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,21852707 0,2324169 ! JNK cascade GO:0007254 106 49 0,000 0,22253394 0,23657547 ! protein homooligomerization GO:0051260 84 49 0,000 0,22253394 0,23647256 ! regulation of ion transport GO:0043269 86 50 0,000 0,22652039 0,24060404 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,22652039 0,24049948 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,22652039 0,240395 GO:0019724|B cell mediated immunity, ! epidermal cell differentiation GO:0009913 87 50 0,000 0,22652039 0,24029062 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,22652039 0,24018633 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,2304865 0,24428569 ! viral infectious cycle GO:0019058 104 51 0,000 0,2304865 0,24417976 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,2304865 0,24407391 ! peptide metabolic process GO:0006518 80 51 0,000 0,2304865 0,24396816 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,23443239 0,24803739 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,23443239 0,24793001 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,23443239 0,24782273 ! excretion GO:0007588 87 52 0,000 0,23443239 0,24771554 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,23443239 0,24760844 ! amino acid activation GO:0043038 98 52 0,000 0,23443239 0,24750144 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,23835816 0,25153735 ! chromatin remodeling GO:0006338 122 53 0,000 0,23835816 0,25142875 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,23835816 0,25132023 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,23835816 0,25121181 ! cartilage development GO:0051216 99 53 0,000 0,23835816 0,25110348 ! regulation of translational initiation GO:0006446 87 54 0,000 0,2422639 0,25510807 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,2422639 0,25499815 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,2422639 0,25488833 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,2422639 0,25477861 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,2422639 0,25466898 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,2422639 0,25455945 ! membrane fusion GO:0006944 122 54 0,000 0,2422639 0,25445001 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,2422639 0,25434066 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,2422639 0,25423141 ! regulation of cell shape GO:0008360 142 54 0,000 0,2422639 0,25412225 ! RNA catabolic process GO:0006401 103 55 0,000 0,24614973 0,25808746 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,24614973 0,25797674 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,24614973 0,25786612 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,24614973 0,25775559 ! cell recognition GO:0008037 98 55 0,000 0,24614973 0,25764515 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,24614973 0,25753481 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,25001574 0,26146766 ! glucose catabolic process GO:0006007 88 56 0,000 0,25001574 0,26135577 ! chloride transport GO:0006821 102 57 0,000 0,25386203 0,26526302 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,25386203 0,26514961 ! regulation of actin filament length GO:0030832 118 58 0,000 0,2576887 0,26903141 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,2576887 0,26891648 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,2576887 0,26880166 ! gastrulation GO:0007369 122 58 0,000 0,2576887 0,26868694 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,2576887 0,26857231 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,2576887 0,26845778 ! maintenance of location GO:0051235 124 58 0,000 0,2576887 0,26834335 ! nuclear export GO:0051168 110 59 0,000 0,26149585 0,27219189 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,26528359 0,27601695 ! regulation of endocytosis GO:0030100 104 60 0,000 0,26528359 0,27589945 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,26528359 0,27578204 ! adult behavior GO:0030534 104 60 0,000 0,26528359 0,27566474 ! positive regulation of secretion GO:0051047 110 61 0,000 0,269052 0,27946175 ! regulation of cellular component size GO:0032535 125 61 0,000 0,269052 0,27934298 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,269052 0,27922431 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,269052 0,27910575 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,269052 0,27898728 ! regulation of heart contraction GO:0008016 123 61 0,000 0,269052 0,27886892 ! proton transport GO:0015992 117 61 0,000 0,269052 0,27875065 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,27280119 0,28251518 ! tRNA processing GO:0008033 102 62 0,000 0,27280119 0,28239547 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,27653126 0,28613548 ! mesoderm development GO:0007498 128 63 0,000 0,27653126 0,28601433 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,27653126 0,2858933 ! hydrogen transport GO:0006818 121 64 0,000 0,28024229 0,28960741 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,28024229 0,28948496 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,2839344 0,29317487 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,2839344 0,29305101 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,28760767 0,29671686 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,28760767 0,29659161 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,2912622 0,30023357 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,2912622 0,30010694 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,2912622 0,29998042 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,29489808 0,30359714 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,29489808 0,30346926 ! hexose catabolic process GO:0019320 113 68 0,000 0,29489808 0,30334148 ! extracellular matrix organization GO:0030198 146 68 0,000 0,29489808 0,30321381 ! regulation of lipase activity GO:0060191 137 68 0,000 0,29489808 0,30308625 ! cell projection assembly GO:0030031 138 68 0,000 0,29489808 0,3029588 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,29851542 0,3065461 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,29851542 0,3064173 ! single fertilization GO:0007338 83 69 0,000 0,29851542 0,3062886 ! cell redox homeostasis GO:0045454 114 70 0,000 0,30211429 0,30985106 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,30211429 0,30972103 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,30569481 0,31326024 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,30569481 0,3131289 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,30569481 0,31299766 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,30925706 0,31651235 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,30925706 0,31637981 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,31280112 0,31987156 ! acute inflammatory response GO:0002526 118 74 0,000 0,31632711 0,32334189 ! amino acid transport GO:0006865 148 74 0,000 0,31632711 0,32320666 ! transition metal ion transport GO:0000041 143 75 0,000 0,3198351 0,32665433 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,32332519 0,33008084 ! regulation of blood pressure GO:0008217 134 76 0,000 0,32332519 0,32994296 ! amine catabolic process GO:0009310 136 77 0,000 0,32679747 0,33334707 ! neurotransmitter transport GO:0006836 142 77 0,000 0,32679747 0,33320794 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,32679747 0,33306893 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,32679747 0,33293003 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,33025203 0,33630917 ! fertilization GO:0009566 99 78 0,000 0,33025203 0,33616905 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,33368896 0,33952608 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,33368896 0,33938473 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,33368896 0,3392435 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,33710835 0,34257724 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,33710835 0,3424348 ! muscle cell differentiation GO:0042692 178 81 0,000 0,34051028 0,34574673 ! protein import into nucleus GO:0006606 174 82 0,000 0,34389486 0,34903828 ! exocytosis GO:0006887 153 83 0,000 0,34726216 0,35230957 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,34726216 0,35216332 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,34726216 0,3520172 ! nuclear import GO:0051170 177 83 0,000 0,34726216 0,35187119 ! inorganic anion transport GO:0015698 156 83 0,000 0,34726216 0,35172531 ! digestion GO:0007586 130 84 0,000 0,35061227 0,35497131 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,35394528 0,35819731 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,35394528 0,35804899 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,36056035 0,36458979 ! alcohol catabolic process GO:0046164 142 87 0,000 0,36056035 0,36443894 ! nucleosome assembly GO:0006334 126 87 0,000 0,36056035 0,36428822 ! cellular respiration GO:0045333 143 88 0,000 0,36384258 0,36745242 ! sensory perception of smell GO:0007608 117 88 0,000 0,36384258 0,36730058 ! chromatin assembly GO:0031497 128 88 0,000 0,36384258 0,36714887 ! cellular defense response GO:0006968 123 89 0,000 0,36710805 0,37029107 ! protein localization in nucleus GO:0034504 192 89 0,000 0,36710805 0,37013824 ! regulation of neurological system process GO:0031644 175 89 0,000 0,36710805 0,36998555 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,37035685 0,37310589 ! ossification GO:0001503 205 91 0,000 0,37358907 0,37620697 ! defense response to bacterium GO:0042742 112 91 0,000 0,37358907 0,37605196 ! bone development GO:0060348 206 92 0,000 0,37680479 0,37913266 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,37680479 0,37897657 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,38000409 0,38203703 ! amine transport GO:0015837 181 93 0,000 0,38000409 0,38187988 ! vitamin metabolic process GO:0006766 153 93 0,000 0,38000409 0,38172286 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,38318705 0,38476201 ! sterol metabolic process GO:0016125 166 94 0,000 0,38318705 0,38460393 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,38318705 0,38444598 ! regulation of defense response GO:0031347 171 95 0,000 0,38635376 0,38746398 ! nucleosome organization GO:0034728 143 95 0,000 0,38635376 0,38730498 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,38635376 0,38714612 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,38635376 0,38698739 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,38635376 0,38682879 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,39263876 0,39296047 ! mRNA transport GO:0051028 185 100 0,000 0,40194643 0,40211102 ! hormone metabolic process GO:0042445 171 100 0,000 0,40194643 0,40194643