pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6604-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 1,763E-08 4,054E-05 ! positive regulation of phosphorylation GO:0042327 102 70 5,000 1,546E-07 1,778E-04 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 5,000 1,832E-07 1,405E-04 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of epithelial cell proliferation GO:0050678 71 39 4,000 2,3E-07 1,322E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 2,621E-07 1,206E-04 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 4,999E-07 1,916E-04 ! ER overload response GO:0006983 7 6 2,000 8,025E-07 2,637E-04 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 9,362E-07 2,691E-04 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 1,13E-06 2,889E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 1,353E-06 3,111E-04 ! regulation of granule cell precursor proliferation GO:0021936 11 7 2,000 1,401E-06 2,929E-04 GO:0021940|positive regulation of granule cell precursor proliferation, ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,401E-06 2,685E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 1,606E-06 2,842E-04 GO:0045936|negative regulation of phosphate metabolic process, ! activation of MAPK activity GO:0000187 84 59 4,000 1,896E-06 3,115E-04 ! induction of positive chemotaxis GO:0050930 14 8 2,000 2,236E-06 3,428E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,236E-06 3,214E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 2,633E-06 3,563E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 3,345E-06 4,274E-04 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 5,752E-06 6,963E-04 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 6,538E-06 7,519E-04 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 6,538E-06 7,161E-04 ! negative regulation of glucose import GO:0046325 14 11 2,000 6,538E-06 6,835E-04 GO:0010829|negative regulation of glucose transport, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,128E-05 1,128E-03 ! activation of MAPKK activity GO:0000186 21 14 2,000 1,432E-05 1,372E-03 ! regulation of gene-specific transcription GO:0032583 69 43 3,000 1,495E-05 1,376E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 1,495E-05 1,323E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,785E-05 1,521E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 1,796E-05 1,475E-03 ! response to UV GO:0009411 75 46 3,000 1,962E-05 1,556E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,192E-05 1,68E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 2,434E-05 1,806E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,655E-05 1,908E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 2,655E-05 1,85E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 2,965E-05 2,006E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 2,965E-05 1,949E-03 ! regulation of glucose import GO:0046324 21 18 2,000 3,178E-05 2,03E-03 GO:0010827|regulation of glucose transport, ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 3,764E-05 2,34E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 4,302E-05 2,604E-03 ! positive regulation of locomotion GO:0040017 35 20 2,000 4,417E-05 2,605E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 4,417E-05 2,54E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 4,417E-05 2,478E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 4,614E-05 2,527E-03 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 4,614E-05 2,468E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 4,943E-05 2,584E-03 ! regulation of chemotaxis GO:0050920 36 21 2,000 5,141E-05 2,627E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 5,141E-05 2,57E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 5,141E-05 2,516E-03 ! regulation of behavior GO:0050795 38 22 2,000 5,938E-05 2,845E-03 ! protein tetramerization GO:0051262 39 22 2,000 5,938E-05 2,787E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 6,033E-05 2,775E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 6,811E-05 3,072E-03 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 6,811E-05 3,013E-03 ! myelination GO:0042552 35 23 2,000 6,811E-05 2,956E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 7,288E-05 3,104E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 7,765E-05 3,247E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 9,925E-05 4,077E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 9,925E-05 4,005E-03 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 1,000 1,19E-04 4,717E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,19E-04 4,637E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,19E-04 4,56E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,19E-04 4,485E-03 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 1,19E-04 4,413E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 1,19E-04 4,343E-03 ! negative regulation of transport GO:0051051 116 73 3,000 1,22E-04 4,383E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,244E-04 4,403E-03 ! ensheathment of neurons GO:0007272 43 28 2,000 1,244E-04 4,337E-03 GO:0008366|axon ensheathment, ! cellular response to hormone stimulus GO:0032870 109 74 3,000 1,286E-04 4,415E-03 ! positive regulation of protein modification process GO:0031401 107 78 3,000 1,578E-04 5,336E-03 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,695E-04 5,649E-03 GO:0060326|cell chemotaxis, ! regulation of helicase activity GO:0051095 11 6 1,000 1,78E-04 5,85E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,78E-04 5,767E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,78E-04 5,687E-03 ! male sex determination GO:0030238 9 6 1,000 1,78E-04 5,609E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,78E-04 5,533E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 2,3E-04 7,055E-03 ! regulation of action potential in neuron GO:0019228 54 35 2,000 2,443E-04 7,394E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,487E-04 7,428E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 2,487E-04 7,333E-03 ! microtubule bundle formation GO:0001578 8 7 1,000 2,487E-04 7,24E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 2,487E-04 7,15E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 2,487E-04 7,061E-03 ! fibrinolysis GO:0042730 9 7 1,000 2,487E-04 6,975E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 2,487E-04 6,891E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 2,487E-04 6,809E-03 ! response to tumor cell GO:0002347 12 7 1,000 2,487E-04 6,729E-03 ! positive regulation of ATPase activity GO:0032781 10 7 1,000 2,487E-04 6,651E-03 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 1,000 2,487E-04 6,574E-03 ! interphase GO:0051325 159 88 3,000 2,513E-04 6,568E-03 ! gliogenesis GO:0042063 71 38 2,000 3,126E-04 8,078E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 3,308E-04 8,455E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 3,308E-04 8,362E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 3,308E-04 8,271E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 3,308E-04 8,182E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 3,308E-04 8,095E-03 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 3,308E-04 8,01E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 3,308E-04 7,926E-03 ! induction of an organ GO:0001759 11 8 1,000 3,308E-04 7,845E-03 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 1,000 3,308E-04 7,765E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 3,308E-04 7,686E-03 ! regulation of response to external stimulus GO:0032101 139 96 3,000 3,506E-04 8,065E-03 ! response to light stimulus GO:0009416 153 96 3,000 3,506E-04 7,985E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 3,643E-04 8,214E-03 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 4,244E-04 9,477E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 4,244E-04 9,386E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 4,244E-04 9,297E-03 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 4,244E-04 9,209E-03 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 15 9 1,000 4,244E-04 9,123E-03 ! motor axon guidance GO:0008045 14 9 1,000 4,244E-04 9,038E-03 ! localization within membrane GO:0051668 15 9 1,000 4,244E-04 8,955E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 4,516E-04 9,444E-03 ! leukocyte migration GO:0050900 60 43 2,000 4,516E-04 9,358E-03 ! regulation of action potential GO:0001508 71 44 2,000 4,835E-04 9,929E-03 ! negative regulation of cell migration GO:0030336 92 44 2,000 4,835E-04 9,841E-03 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 4,835E-04 9,755E-03 ! regulation of inflammatory response GO:0050727 60 44 2,000 4,835E-04 9,67E-03 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 4,835E-04 9,587E-03 ! positive regulation of cell cycle GO:0045787 77 45 2,000 5,167E-04 0,01015831 ! positive regulation of defense response GO:0031349 59 45 2,000 5,167E-04 0,01007222 ! regulation of B cell proliferation GO:0030888 15 10 1,000 5,293E-04 0,0102305 ! response to X-ray GO:0010165 16 10 1,000 5,293E-04 0,01014525 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 5,293E-04 0,0100614 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 5,293E-04 9,979E-03 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 5,293E-04 9,898E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 5,876E-04 0,01089851 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of muscle contraction GO:0006937 69 48 2,000 6,252E-04 0,01150353 ! regulation of DNA replication GO:0006275 75 48 2,000 6,252E-04 0,01141223 ! virus-host interaction GO:0019048 17 11 1,000 6,455E-04 0,01168998 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 6,455E-04 0,01159865 ! regulation of intracellular pH GO:0051453 17 11 1,000 6,455E-04 0,01150874 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 6,455E-04 0,01142021 GO:0042130|negative regulation of T cell proliferation, ! regulation of angiogenesis GO:0045765 94 49 2,000 6,643E-04 0,01166358 ! cartilage development GO:0051216 70 49 2,000 6,643E-04 0,01157522 ! negative regulation of cell motion GO:0051271 104 51 2,000 7,472E-04 0,01292114 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 7,728E-04 0,01326532 ! cell-cell junction assembly GO:0007043 18 12 1,000 7,728E-04 0,01316706 ! negative regulation of endothelial cell migration GO:0010596 21 12 1,000 7,728E-04 0,01307024 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 7,728E-04 0,01297484 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! response to gamma radiation GO:0010332 20 12 1,000 7,728E-04 0,01288082 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 7,728E-04 0,01278815 ! nucleotide-excision repair GO:0006289 64 52 2,000 7,91E-04 0,01299439 ! regulation of cellular pH GO:0030641 20 13 1,000 9,113E-04 0,01486545 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 9,113E-04 0,01476077 ! regulation of calcium-mediated signaling GO:0050848 18 13 1,000 9,113E-04 0,01465754 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 9,823E-04 0,01568992 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 1,061E-03 0,01682675 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,061E-03 0,0167115 ! cellular response to starvation GO:0009267 21 14 1,000 1,061E-03 0,01659782 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 1,061E-03 0,01648567 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,061E-03 0,01637503 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,061E-03 0,01626586 ! negative regulation of blood coagulation GO:0030195 19 14 1,000 1,061E-03 0,01615814 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 1,061E-03 0,01605183 ! regulation of ATPase activity GO:0043462 18 14 1,000 1,061E-03 0,01594692 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,061E-03 0,01584337 ! regulation of heart contraction GO:0008016 91 60 2,000 1,201E-03 0,01781718 ! lipid phosphorylation GO:0046834 23 15 1,000 1,221E-03 0,01800595 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 1,221E-03 0,01789126 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 1,221E-03 0,01777803 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 1,221E-03 0,01766622 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,221E-03 0,0175558 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 1,221E-03 0,01744676 ! negative regulation of cell growth GO:0030308 106 62 2,000 1,32E-03 0,01874771 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,393E-03 0,01965032 ! mitotic chromosome condensation GO:0007076 25 16 1,000 1,393E-03 0,0195305 ! G1 phase GO:0051318 27 16 1,000 1,393E-03 0,01941214 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,393E-03 0,0192952 ! negative regulation of translation GO:0017148 22 16 1,000 1,393E-03 0,01917966 ! negative regulation of cell size GO:0045792 108 64 2,000 1,448E-03 0,01981733 ! protein oligomerization GO:0051259 100 65 2,000 1,514E-03 0,02060229 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,575E-03 0,02130546 ! neuromuscular junction development GO:0007528 23 17 1,000 1,575E-03 0,02118087 ! peptidyl-serine modification GO:0018209 27 17 1,000 1,575E-03 0,02105773 ! cell-cell junction organization GO:0045216 25 17 1,000 1,575E-03 0,020936 ! negative regulation of coagulation GO:0050819 23 17 1,000 1,575E-03 0,02081568 ! positive regulation of DNA replication GO:0045740 29 18 1,000 1,768E-03 0,02323162 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 1,768E-03 0,02309963 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 1,768E-03 0,02296912 ! cellular response to nutrient levels GO:0031669 27 18 1,000 1,768E-03 0,02284008 ! activation of JUN kinase activity GO:0007257 23 18 1,000 1,768E-03 0,02271248 ! negative regulation of T cell activation GO:0050868 25 18 1,000 1,768E-03 0,0225863 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 1,768E-03 0,02246151 ! activation of protein kinase activity GO:0032147 102 69 2,000 1,798E-03 0,02272141 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 1,971E-03 0,02477403 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 1,971E-03 0,02463939 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 1,971E-03 0,0245062 ! response to starvation GO:0042594 30 19 1,000 1,971E-03 0,02437445 ! sex determination GO:0007530 29 19 1,000 1,971E-03 0,0242441 ! plasma membrane fusion GO:0045026 23 19 1,000 1,971E-03 0,02411514 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 1,971E-03 0,02398755 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,971E-03 0,0238613 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 1,971E-03 0,02373637 ! chromosome condensation GO:0030261 31 20 1,000 2,185E-03 0,02617759 ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,185E-03 0,02604195 ! blood coagulation GO:0007596 116 75 2,000 2,283E-03 0,02706764 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 2,000 2,283E-03 0,02692884 ! regulation of protein transport GO:0051223 114 76 2,000 2,371E-03 0,02782367 GO:0070201|regulation of establishment of protein localization, ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,41E-03 0,0281356 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 2,41E-03 0,0279935 ! dendrite development GO:0016358 35 21 1,000 2,41E-03 0,02785283 ! cell aging GO:0007569 32 21 1,000 2,41E-03 0,02771357 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 2,41E-03 0,02757569 ! platelet activation GO:0030168 28 21 1,000 2,41E-03 0,02743918 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 2,645E-03 0,02996714 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 2,645E-03 0,02982024 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 2,645E-03 0,02967477 GO:0010810|regulation of cell-substrate adhesion, ! regulation of blood coagulation GO:0030193 34 22 1,000 2,645E-03 0,02953072 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 2,645E-03 0,02938806 ! hemostasis GO:0007599 125 81 2,000 2,842E-03 0,03142988 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 2,89E-03 0,03180753 ! negative regulation of DNA replication GO:0008156 35 23 1,000 2,89E-03 0,03165606 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 2,89E-03 0,03150603 ! interaction with host GO:0051701 37 23 1,000 2,89E-03 0,03135742 ! regulation of cell adhesion GO:0030155 159 83 2,000 3,046E-03 0,03288958 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 3,146E-03 0,03381252 ! mitochondrial membrane organization GO:0007006 39 24 1,000 3,146E-03 0,03365526 ! negative regulation of cell development GO:0010721 56 24 1,000 3,146E-03 0,03349944 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 3,146E-03 0,03334507 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 3,146E-03 0,03319211 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 3,146E-03 0,03304055 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 3,146E-03 0,03289036 ! regulation of defense response GO:0031347 117 84 2,000 3,151E-03 0,03279205 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 3,258E-03 0,03375529 ! regulation of protein localization GO:0032880 132 85 2,000 3,258E-03 0,03360392 ! regulation of membrane potential GO:0042391 128 85 2,000 3,258E-03 0,0334539 ! cell cycle arrest GO:0007050 150 86 2,000 3,368E-03 0,03442403 ! positive regulation of nuclear division GO:0051785 39 25 1,000 3,412E-03 0,03472337 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 3,412E-03 0,03457041 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 3,412E-03 0,03441878 ! regulation of pH GO:0006885 36 26 1,000 3,688E-03 0,03704112 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 3,688E-03 0,03688007 ! regulation of coagulation GO:0050818 39 26 1,000 3,688E-03 0,03672041 ! response to ionizing radiation GO:0010212 47 27 1,000 3,974E-03 0,03939877 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 3,974E-03 0,03922968 ! cell fate commitment GO:0045165 141 92 2,000 4,072E-03 0,0400203 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 4,197E-03 0,04107701 ! cell junction assembly GO:0034329 56 28 1,000 4,27E-03 0,04161701 ! positive regulation of catabolic process GO:0009896 40 28 1,000 4,27E-03 0,04144141 ! regulation of B cell activation GO:0050864 42 28 1,000 4,27E-03 0,04126729 ! regulation of microtubule-based process GO:0032886 58 30 1,000 4,892E-03 0,0470802 ! negative regulation of cell activation GO:0050866 44 30 1,000 4,892E-03 0,04688403 ! regulation of body fluid levels GO:0050878 154 100 2,000 5,14E-03 0,04905832 ! DNA damage checkpoint GO:0000077 53 31 1,000 5,218E-03 0,04959213 ! negative regulation of secretion GO:0051048 49 31 1,000 5,218E-03 0,04938805 ! mammary gland development GO:0030879 57 31 1,000 5,218E-03 0,04918564 ! glial cell differentiation GO:0010001 55 31 1,000 5,218E-03 0,04898488 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 5,218E-03 0,04878576 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 5,218E-03 0,04858824 ! cell fate specification GO:0001708 37 31 1,000 5,218E-03 0,04839232 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 5,553E-03 0,0512963 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 5,553E-03 0,05109111 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 5,553E-03 0,05088756 ! peripheral nervous system development GO:0007422 53 32 1,000 5,553E-03 0,05068563 ! calcium-mediated signaling GO:0019722 50 32 1,000 5,553E-03 0,05048529 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 5,553E-03 0,05028653 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 5,898E-03 0,05320178 ! sister chromatid segregation GO:0000819 46 33 1,000 5,898E-03 0,05299396 ! cell junction organization GO:0034330 63 33 1,000 5,898E-03 0,05278776 ! carbohydrate homeostasis GO:0033500 39 33 1,000 5,898E-03 0,05258316 GO:0042593|glucose homeostasis, ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 5,898E-03 0,05238014 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 5,898E-03 0,05217867 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 6,253E-03 0,05510409 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 6,253E-03 0,05489377 ! DNA integrity checkpoint GO:0031570 57 34 1,000 6,253E-03 0,05468504 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 6,617E-03 0,05765059 ! glycogen metabolic process GO:0005977 48 35 1,000 6,617E-03 0,05743304 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 6,617E-03 0,05721712 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 49 36 1,000 6,991E-03 0,06022121 GO:0006073|cellular glucan metabolic process, ! regulation of protein secretion GO:0050708 51 37 1,000 7,374E-03 0,06328333 ! regulation of T cell proliferation GO:0042129 58 38 1,000 7,766E-03 0,06640226 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 8,168E-03 0,0695768 ! JNK cascade GO:0007254 54 39 1,000 8,168E-03 0,06932006 ! cell growth GO:0016049 61 39 1,000 8,168E-03 0,06906521 ! synapse organization GO:0050808 55 39 1,000 8,168E-03 0,06881222 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 8,578E-03 0,07200862 ! peptide metabolic process GO:0006518 56 40 1,000 8,578E-03 0,07174677 ! T cell differentiation GO:0030217 65 40 1,000 8,578E-03 0,07148682 ! double-strand break repair GO:0006302 67 40 1,000 8,578E-03 0,07122874 ! B cell differentiation GO:0030183 62 40 1,000 8,578E-03 0,07097253 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 8,578E-03 0,07071814 ! positive regulation of protein transport GO:0051222 55 40 1,000 8,578E-03 0,07046558 ! energy reserve metabolic process GO:0006112 59 41 1,000 8,998E-03 0,073651 ! regulation of T cell differentiation GO:0045580 59 41 1,000 8,998E-03 0,07338983 ! regulation of JNK cascade GO:0046328 58 41 1,000 8,998E-03 0,0731305 ! mitochondrial transport GO:0006839 60 42 1,000 9,427E-03 0,0763461 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 9,427E-03 0,07607822 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 9,427E-03 0,07581221 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 9,427E-03 0,07554806 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 9,427E-03 0,07528574 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 9,427E-03 0,07502523 ! activation of caspase activity GO:0006919 65 43 1,000 9,865E-03 0,07823894 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,01123157 0,08877189 ! regulation of ossification GO:0030278 71 46 1,000 0,01123157 0,08846788 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,01170464 0,09187943 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,01170464 0,09156692 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,01170464 0,09125652 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01218636 0,09469128 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,01218636 0,09437245 ! heart morphogenesis GO:0003007 65 48 1,000 0,01218636 0,09405577 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,01218636 0,0937412 ! RNA elongation GO:0006354 62 49 1,000 0,01267666 0,09718769 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,01267666 0,09686481 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,01267666 0,09654407 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,01317548 0,10001186 ! membrane fusion GO:0006944 80 50 1,000 0,01317548 0,09968288 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,01317548 0,09935605 ! lipid modification GO:0030258 73 50 1,000 0,01317548 0,09903135 ! positive regulation of growth GO:0045927 67 50 1,000 0,01317548 0,09870878 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01368275 0,1021764 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,01368275 0,10184574 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,01368275 0,1015172 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01419842 0,10500443 ! aging GO:0007568 79 52 1,000 0,01419842 0,10466788 ! single fertilization GO:0007338 59 53 1,000 0,01472243 0,10818397 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,01472243 0,10783944 ! regulation of mitosis GO:0007088 84 54 1,000 0,0152547 0,11138352 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,0152547 0,11103104 ! DNA catabolic process GO:0006308 67 54 1,000 0,0152547 0,11068079 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,0152547 0,11033274 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,0152547 0,10998686 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,0163438 0,11747109 ! chromosome segregation GO:0007059 83 57 1,000 0,01690051 0,121094 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01732716 0,1237654 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01732716 0,12338223 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01732716 0,12300142 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01732716 0,12262296 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01732716 0,12224681 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01732716 0,12187297 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01732716 0,1215014 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01732716 0,1211321 ! sleep GO:0030431 11 5 0,000 0,01732716 0,12076503 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01732716 0,12040018 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01732716 0,12003753 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01732716 0,11967706 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01732716 0,11931874 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01732716 0,11896257 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01732716 0,11860851 ! tongue development GO:0043586 6 5 0,000 0,01732716 0,11825656 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01732716 0,11790669 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01732716 0,11755888 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01732716 0,11721312 ! cobalt ion transport GO:0006824 9 5 0,000 0,01732716 0,11686939 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01732716 0,11652766 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01732716 0,11618793 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01732716 0,11585018 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01732716 0,11551438 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01732716 0,11518052 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01732716 0,11484859 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01732716 0,11451856 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01732716 0,11419043 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01732716 0,11386417 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01732716 0,11353977 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01732716 0,11321722 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01732716 0,11289649 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01732716 0,11257757 ! malate metabolic process GO:0006108 7 5 0,000 0,01732716 0,11226045 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01732716 0,11194511 ! behavioral response to pain GO:0048266 7 5 0,000 0,01732716 0,11163154 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01732716 0,11131972 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01732716 0,11100964 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01732716 0,11070128 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01732716 0,11039463 ! mating behavior GO:0007617 6 5 0,000 0,01732716 0,11008967 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01732716 0,10978639 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01732716 0,10948478 ! rhythmic behavior GO:0007622 12 5 0,000 0,01732716 0,10918482 ! copulation GO:0007620 7 5 0,000 0,01732716 0,1088865 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01732716 0,10858981 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01732716 0,10829473 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01732716 0,10800125 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01732716 0,10770935 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01732716 0,10741903 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01732716 0,10713027 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01732716 0,10684306 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01732716 0,10655738 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01732716 0,10627323 ! response to protozoan GO:0001562 9 5 0,000 0,01732716 0,10599059 ! lymph vessel development GO:0001945 7 5 0,000 0,01732716 0,10570944 ! endochondral ossification GO:0001958 12 5 0,000 0,01732716 0,10542979 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01732716 0,10515161 ! parathyroid gland development GO:0060017 8 5 0,000 0,01732716 0,1048749 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01732716 0,10459963 ! anagen GO:0042640 6 5 0,000 0,01732716 0,10432581 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01732716 0,10405342 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01732716 0,10378245 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01732716 0,10351288 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01732716 0,10324472 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01732716 0,10297793 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01732716 0,10271253 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01732716 0,10244848 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01732716 0,1021858 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01732716 0,10192445 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01732716 0,10166444 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01732716 0,10140575 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01732716 0,10114838 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01732716 0,1008923 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01732716 0,10063753 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01732716 0,10038403 ! ovulation GO:0030728 6 5 0,000 0,01732716 0,10013181 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01732716 0,09988085 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01732716 0,09963115 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01732716 0,09938269 ! response to pH GO:0009268 9 5 0,000 0,01732716 0,09913547 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01732716 0,09888948 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01732716 0,0986447 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01732716 0,09840114 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01732716 0,09815877 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01732716 0,09791759 ! polyol catabolic process GO:0046174 7 5 0,000 0,01732716 0,0976776 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01732716 0,09743878 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01732716 0,09720112 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01732716 0,09696462 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01732716 0,09672927 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01732716 0,09649506 ! urea metabolic process GO:0019627 6 5 0,000 0,01732716 0,09626198 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01732716 0,09603003 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01732716 0,09579918 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01732716 0,09556945 ! neutrophil activation GO:0042119 5 5 0,000 0,01732716 0,09534081 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01732716 0,09511327 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01732716 0,09488681 ! response to food GO:0032094 5 5 0,000 0,01732716 0,09466143 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01732716 0,09443711 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01732716 0,09421385 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01732716 0,09399165 ! forebrain neuron development GO:0021884 7 5 0,000 0,01732716 0,0937705 ! melanosome organization GO:0032438 7 5 0,000 0,01732716 0,09355038 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01732716 0,09333129 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01732716 0,09311323 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01732716 0,09289618 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01732716 0,09268014 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01732716 0,09246511 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01732716 0,09225107 ! nucleoside transport GO:0015858 6 5 0,000 0,01732716 0,09203801 ! nucleoside salvage GO:0043174 7 5 0,000 0,01732716 0,09182595 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01732716 0,09161485 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01732716 0,09140473 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01732716 0,09119556 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01732716 0,09098735 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01732716 0,09078009 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01732716 0,09057377 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01732716 0,09036839 ! depyrimidination GO:0045008 8 5 0,000 0,01732716 0,09016394 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01732716 0,08996041 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01732716 0,08975779 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01732716 0,08955609 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01732716 0,08935529 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01732716 0,08915539 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01732716 0,08895638 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01732716 0,08875826 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01732716 0,08856102 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01732716 0,08836466 ! monocyte differentiation GO:0030224 8 5 0,000 0,01732716 0,08816916 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01732716 0,08797453 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01732716 0,08778075 ! centrosome duplication GO:0051298 5 5 0,000 0,01732716 0,08758783 ! response to UV-C GO:0010225 6 5 0,000 0,01732716 0,08739575 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01732716 0,08720451 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01732716 0,08701411 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01732716 0,08682453 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01732716 0,08663578 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01732716 0,08644785 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01732716 0,08626074 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01732716 0,08607443 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01732716 0,08588892 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01732716 0,08570422 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01732716 0,0855203 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01732716 0,08533717 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01732716 0,08515483 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01732716 0,08497326 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01732716 0,08479247 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01732716 0,08461244 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01732716 0,08443318 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01732716 0,08425467 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01732716 0,08407692 ! neural tube patterning GO:0021532 6 5 0,000 0,01732716 0,08389992 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01732716 0,08372366 ! histone demethylation GO:0016577 9 5 0,000 0,01732716 0,08354814 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01732716 0,08337335 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01732716 0,08319929 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01732716 0,08302596 ! enteric nervous system development GO:0048484 8 5 0,000 0,01732716 0,08285335 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01732716 0,08268145 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01732716 0,08251027 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01732716 0,08233979 ! transcription termination GO:0006353 8 5 0,000 0,01732716 0,08217002 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01732716 0,08200095 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01732716 0,08183257 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01732716 0,08166488 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01732716 0,08149787 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01732716 0,08133155 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01732716 0,08116591 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01732716 0,08100094 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01732716 0,08083663 ! apical protein localization GO:0045176 6 5 0,000 0,01732716 0,080673 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01732716 0,08051002 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01732716 0,0803477 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01732716 0,08018604 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01732716 0,08002502 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01732716 0,07986465 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01732716 0,07970492 ! glial cell migration GO:0008347 10 5 0,000 0,01732716 0,07954583 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01732716 0,07938737 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01732716 0,07922954 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01732716 0,07907234 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01732716 0,07891576 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01732716 0,0787598 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01732716 0,07860446 ! neural plate development GO:0001840 6 5 0,000 0,01732716 0,07844973 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01732716 0,0782956 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01732716 0,07814208 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01732716 0,07798916 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01732716 0,07783684 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01732716 0,07768511 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01732716 0,07753397 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01732716 0,07738342 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01732716 0,07723345 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01732716 0,07708406 ! spindle assembly GO:0051225 5 5 0,000 0,01732716 0,07693525 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01732716 0,07678701 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01732716 0,07663935 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01732716 0,07649225 ! organ regeneration GO:0031100 7 5 0,000 0,01732716 0,07634571 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01732716 0,07619973 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01732716 0,07605431 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01732716 0,07590945 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01732716 0,07576513 GO:0055081|anion homeostasis, ! viral reproductive process GO:0022415 87 58 1,000 0,01746524 0,07622401 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,01746524 0,07607965 ! lung development GO:0030324 94 59 1,000 0,01803793 0,0784258 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,01861853 0,08079738 ! fertilization GO:0009566 68 60 1,000 0,01861853 0,08064522 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,01861853 0,08049363 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,01920696 0,08288182 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,01920696 0,08272661 ! respiratory tube development GO:0030323 99 62 1,000 0,01980318 0,08513516 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,01980318 0,08497632 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,02040711 0,08740477 ! viral reproduction GO:0016032 92 63 1,000 0,02040711 0,08724231 ! regulation of lipase activity GO:0060191 109 63 1,000 0,02040711 0,08708045 ! tRNA transcription GO:0009304 11 6 0,000 0,02075698 0,08840936 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02075698 0,08824595 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02075698 0,08808313 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02075698 0,08792091 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02075698 0,0877593 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02075698 0,08759827 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02075698 0,08743783 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02075698 0,08727798 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02075698 0,08711872 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02075698 0,08696003 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02075698 0,08680192 ! prostate gland development GO:0030850 9 6 0,000 0,02075698 0,08664439 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02075698 0,08648742 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02075698 0,08633103 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02075698 0,08617519 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02075698 0,08601992 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02075698 0,08586521 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02075698 0,08571105 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02075698 0,08555745 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02075698 0,0854044 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02075698 0,08525189 ! neuron adhesion GO:0007158 9 6 0,000 0,02075698 0,08509992 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,02075698 0,0849485 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02075698 0,08479761 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02075698 0,08464726 ! signal peptide processing GO:0006465 8 6 0,000 0,02075698 0,08449745 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02075698 0,08434816 ! mRNA stabilization GO:0048255 15 6 0,000 0,02075698 0,08419939 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02075698 0,08405116 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02075698 0,08390344 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02075698 0,08375624 ! opsonization GO:0008228 8 6 0,000 0,02075698 0,08360956 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02075698 0,08346339 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02075698 0,08331773 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02075698 0,08317257 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02075698 0,08302792 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02075698 0,08288378 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02075698 0,08274013 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02075698 0,08259698 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02075698 0,08245433 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02075698 0,08231217 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02075698 0,08217049 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02075698 0,08202931 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02075698 0,08188861 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02075698 0,08174839 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02075698 0,08160864 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02075698 0,08146938 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02075698 0,08133059 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02075698 0,08119227 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02075698 0,08105443 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02075698 0,08091705 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02075698 0,08078013 ! thymic T cell selection GO:0045061 12 6 0,000 0,02075698 0,08064368 ! protein lipoylation GO:0009249 10 6 0,000 0,02075698 0,08050768 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02075698 0,08037215 ! pigment granule organization GO:0048753 11 6 0,000 0,02075698 0,08023707 ! drug transport GO:0015893 6 6 0,000 0,02075698 0,08010244 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02075698 0,07996827 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02075698 0,07983454 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02075698 0,07970126 ! histidine metabolic process GO:0006547 6 6 0,000 0,02075698 0,07956843 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02075698 0,07943603 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02075698 0,07930408 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02075698 0,07917257 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02075698 0,07904148 ! adenohypophysis development GO:0021984 10 6 0,000 0,02075698 0,07891084 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02075698 0,07878062 ! hyperosmotic response GO:0006972 8 6 0,000 0,02075698 0,07865083 ! microtubule nucleation GO:0007020 10 6 0,000 0,02075698 0,07852148 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02075698 0,07839254 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02075698 0,07826403 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02075698 0,07813594 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02075698 0,07800826 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02075698 0,07788101 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02075698 0,07775416 ! response to dietary excess GO:0002021 7 6 0,000 0,02075698 0,07762773 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02075698 0,07750172 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02075698 0,07737611 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02075698 0,0772509 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02075698 0,0771261 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02075698 0,0770017 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02075698 0,07687771 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02075698 0,07675411 ! neuron apoptosis GO:0051402 8 6 0,000 0,02075698 0,07663091 ! organic alcohol transport GO:0015850 9 6 0,000 0,02075698 0,0765081 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02075698 0,07638569 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02075698 0,07626367 ! carnitine transport GO:0015879 8 6 0,000 0,02075698 0,07614204 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02075698 0,07602079 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02075698 0,07589993 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02075698 0,07577946 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02075698 0,07565936 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02075698 0,07553965 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02075698 0,07542031 ! parturition GO:0007567 12 6 0,000 0,02075698 0,07530135 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02075698 0,07518277 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02075698 0,07506455 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02075698 0,07494671 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02075698 0,07482924 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02075698 0,07471214 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02075698 0,0745954 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02075698 0,07447903 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02075698 0,07436302 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02075698 0,07424737 ! macrophage differentiation GO:0030225 10 6 0,000 0,02075698 0,07413208 ! astrocyte development GO:0014002 14 6 0,000 0,02075698 0,07401714 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02075698 0,07390256 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02075698 0,07378834 ! interaction with symbiont GO:0051702 8 6 0,000 0,02075698 0,07367447 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02075698 0,07356095 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02075698 0,07344778 ! eating behavior GO:0042755 6 6 0,000 0,02075698 0,07333496 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02075698 0,07322248 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02075698 0,07311035 ! response to copper ion GO:0046688 9 6 0,000 0,02075698 0,07299856 ! DNA topological change GO:0006265 8 6 0,000 0,02075698 0,07288711 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02075698 0,072776 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02075698 0,07266523 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02075698 0,0725548 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02075698 0,0724447 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02075698 0,07233493 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02075698 0,0722255 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02075698 0,0721164 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02075698 0,07200763 ! gas homeostasis GO:0033483 11 6 0,000 0,02075698 0,07189918 ! hair follicle maturation GO:0048820 7 6 0,000 0,02075698 0,07179106 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02075698 0,07168327 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02075698 0,0715758 ! Schwann cell development GO:0014044 14 6 0,000 0,02075698 0,07146865 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02075698 0,07136182 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02075698 0,07125531 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02075698 0,07114912 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02075698 0,07104324 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02075698 0,07093768 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02075698 0,07083243 ! histone ubiquitination GO:0016574 7 6 0,000 0,02075698 0,07072749 ! regulation of meiosis GO:0040020 10 6 0,000 0,02075698 0,07062287 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02075698 0,07051855 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02075698 0,07041454 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02075698 0,07031083 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02075698 0,07020744 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02075698 0,07010434 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02075698 0,07000155 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02075698 0,06989906 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02075698 0,06979687 ! receptor internalization GO:0031623 9 6 0,000 0,02075698 0,06969497 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02075698 0,06959338 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02075698 0,06949208 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02075698 0,06939107 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02075698 0,06929036 ! protein deubiquitination GO:0016579 8 6 0,000 0,02075698 0,06918994 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02075698 0,06908981 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02075698 0,06898997 ! axonal fasciculation GO:0007413 9 6 0,000 0,02075698 0,06889041 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02075698 0,06879115 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02075698 0,06869217 ! midbrain development GO:0030901 6 6 0,000 0,02075698 0,06859347 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02075698 0,06849506 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02075698 0,06839693 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02075698 0,06829908 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02075698 0,06820151 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02075698 0,06810422 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02075698 0,0680072 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02075698 0,06791046 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02075698 0,067814 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02075698 0,06771781 ! adult feeding behavior GO:0008343 6 6 0,000 0,02075698 0,06762189 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02075698 0,06752625 ! blastocyst growth GO:0001832 15 6 0,000 0,02075698 0,06743087 ! pigment granule transport GO:0051904 12 6 0,000 0,02075698 0,06733576 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02075698 0,06724093 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02075698 0,06714635 ! catecholamine transport GO:0051937 7 6 0,000 0,02075698 0,06705205 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02075698 0,066958 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02075698 0,06686423 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02075698 0,06677071 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02075698 0,06667745 ! protein prenylation GO:0018342 10 6 0,000 0,02075698 0,06658446 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02075698 0,06649172 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02075698 0,06639924 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02075698 0,06630702 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02075698 0,06621506 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02075698 0,06612335 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,02101871 0,06686451 ! respiratory system development GO:0060541 100 64 1,000 0,02101871 0,06677216 ! regulation of caspase activity GO:0043281 97 65 1,000 0,02163792 0,06864443 ! B cell activation GO:0042113 104 65 1,000 0,02163792 0,06854988 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,02163792 0,06845558 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,02163792 0,06836155 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,02163792 0,06826778 ! axon guidance GO:0007411 99 66 1,000 0,02226467 0,07014895 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,02226467 0,07005298 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,0228989 0,07195009 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02417503 0,07585617 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02417503 0,07575282 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02417503 0,07564975 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02417503 0,07554697 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02417503 0,07544446 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02417503 0,07534224 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02417503 0,07524028 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02417503 0,07513861 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02417503 0,07503721 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02417503 0,07493608 ! reproductive behavior GO:0019098 12 7 0,000 0,02417503 0,07483522 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02417503 0,07473464 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,02417503 0,07463432 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02417503 0,07453428 ! oligopeptide transport GO:0006857 11 7 0,000 0,02417503 0,0744345 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02417503 0,07433499 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02417503 0,07423574 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02417503 0,07413676 ! RNA methylation GO:0001510 11 7 0,000 0,02417503 0,07403804 ! pericardium development GO:0060039 8 7 0,000 0,02417503 0,07393959 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02417503 0,07384139 ! fibril organization GO:0043206 13 7 0,000 0,02417503 0,07374346 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02417503 0,07364579 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02417503 0,07354837 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02417503 0,07345121 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02417503 0,07335431 ! lipoprotein transport GO:0042953 9 7 0,000 0,02417503 0,07325767 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02417503 0,07316128 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02417503 0,07306514 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02417503 0,07296925 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02417503 0,07287362 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02417503 0,07277823 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02417503 0,0726831 ! chemosensory behavior GO:0007635 9 7 0,000 0,02417503 0,07258821 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02417503 0,07249357 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02417503 0,07239918 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02417503 0,07230503 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02417503 0,07221113 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02417503 0,07211747 ! reflex GO:0060004 12 7 0,000 0,02417503 0,07202405 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02417503 0,07193088 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02417503 0,07183795 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02417503 0,07174525 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02417503 0,0716528 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02417503 0,07156058 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02417503 0,0714686 ! spinal cord patterning GO:0021511 7 7 0,000 0,02417503 0,07137685 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02417503 0,07128535 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02417503 0,07119407 ! adrenal gland development GO:0030325 17 7 0,000 0,02417503 0,07110303 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02417503 0,07101222 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02417503 0,07092164 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02417503 0,0708313 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02417503 0,07074118 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02417503 0,0706513 ! endosome organization GO:0007032 10 7 0,000 0,02417503 0,07056164 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02417503 0,0704722 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02417503 0,070383 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02417503 0,07029402 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02417503 0,07020526 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02417503 0,07011673 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02417503 0,07002843 ! galactose metabolic process GO:0006012 10 7 0,000 0,02417503 0,06994034 ! vesicle fusion GO:0006906 15 7 0,000 0,02417503 0,06985247 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02417503 0,06976483 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02417503 0,06967741 ! organ growth GO:0035265 11 7 0,000 0,02417503 0,0695902 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02417503 0,06950321 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02417503 0,06941644 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02417503 0,06932989 ! retinol metabolic process GO:0042572 9 7 0,000 0,02417503 0,06924355 ! behavioral fear response GO:0001662 13 7 0,000 0,02417503 0,06915742 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02417503 0,06907151 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02417503 0,06898582 ! rRNA modification GO:0000154 12 7 0,000 0,02417503 0,06890033 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02417503 0,06881506 ! response to UV-B GO:0010224 11 7 0,000 0,02417503 0,06873 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02417503 0,06864515 ! intermediate filament organization GO:0045109 11 7 0,000 0,02417503 0,0685605 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02417503 0,06847607 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02417503 0,06839184 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02417503 0,06830782 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02417503 0,06822401 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02417503 0,0681404 ! response to tropane GO:0014073 13 7 0,000 0,02417503 0,068057 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02417503 0,0679738 ! melanosome localization GO:0032400 10 7 0,000 0,02417503 0,06789081 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02417503 0,06780801 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02417503 0,06772542 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02417503 0,06764303 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02417503 0,06756084 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02417503 0,06747885 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02417503 0,06739705 ! mast cell activation GO:0045576 9 7 0,000 0,02417503 0,06731546 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02417503 0,06723406 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02417503 0,06715286 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02417503 0,06707186 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02417503 0,06699105 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02417503 0,06691043 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02417503 0,06683001 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,02417503 0,06674978 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02417503 0,06666975 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02417503 0,0665899 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02417503 0,06651025 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02417503 0,06643079 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02417503 0,06635151 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02417503 0,06627243 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02417503 0,06619354 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02417503 0,06611483 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02417503 0,06603631 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02417503 0,06595797 ! diuresis GO:0030146 12 7 0,000 0,02417503 0,06587982 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02417503 0,06580186 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02417503 0,06572408 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02417503 0,06564648 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02417503 0,06556907 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02417503 0,06549184 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02417503 0,06541479 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02417503 0,06533792 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02417503 0,06526123 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02417503 0,06518472 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02417503 0,0651084 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02417503 0,06503225 ! lymph node development GO:0048535 9 7 0,000 0,02417503 0,06495627 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02417503 0,06488048 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02417503 0,06480486 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02417503 0,06472942 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02417503 0,06465415 ! ATP catabolic process GO:0006200 10 7 0,000 0,02417503 0,06457906 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02417503 0,06450414 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02417503 0,0644294 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02417503 0,06435483 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02417503 0,06428043 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02417503 0,0642062 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02417503 0,06413214 ! muscle adaptation GO:0043500 12 7 0,000 0,02417503 0,06405826 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02417503 0,06398454 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02417503 0,063911 ! retina homeostasis GO:0001895 9 7 0,000 0,02417503 0,06383762 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02417503 0,06376441 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02417503 0,06369137 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02417503 0,0636185 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02417503 0,06354579 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02417503 0,06347325 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02417503 0,06340088 ! response to drug GO:0042493 108 69 1,000 0,02418959 0,06336682 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,02418959 0,06329473 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,02484594 0,06493825 ! regulation of catabolic process GO:0009894 106 70 1,000 0,02484594 0,06486455 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,02550954 0,06652148 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,02550954 0,06644615 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,02550954 0,06637098 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,02618034 0,06803931 ! response to hypoxia GO:0001666 132 72 1,000 0,02618034 0,06796252 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,02618034 0,0678859 ! tube morphogenesis GO:0035239 118 73 1,000 0,02685829 0,06956539 ! mitochondrion organization GO:0007005 104 73 1,000 0,02685829 0,06948714 ! response to oxygen levels GO:0070482 137 74 1,000 0,02754332 0,07117936 ! protein import into nucleus GO:0006606 118 74 1,000 0,02754332 0,07109948 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,02754332 0,07101977 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02758134 0,07103817 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02758134 0,07095871 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,02758134 0,07087943 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02758134 0,07080032 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02758134 0,07072139 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02758134 0,07064264 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02758134 0,07056406 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02758134 0,07048566 ! phosphate transport GO:0006817 10 8 0,000 0,02758134 0,07040742 ! N-glycan processing GO:0006491 12 8 0,000 0,02758134 0,07032937 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02758134 0,07025148 ! UTP metabolic process GO:0046051 8 8 0,000 0,02758134 0,07017377 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02758134 0,07009623 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02758134 0,07001886 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02758134 0,06994166 ! succinate metabolic process GO:0006105 14 8 0,000 0,02758134 0,06986464 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02758134 0,06978778 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02758134 0,06971109 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02758134 0,06963457 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02758134 0,06955821 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02758134 0,06948203 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02758134 0,06940601 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02758134 0,06933015 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02758134 0,06925446 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02758134 0,06917894 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02758134 0,06910358 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02758134 0,06902839 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02758134 0,06895336 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02758134 0,06887849 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02758134 0,06880379 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02758134 0,06872924 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02758134 0,06865486 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02758134 0,06858064 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02758134 0,06850658 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02758134 0,06843268 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02758134 0,06835893 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02758134 0,06828535 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02758134 0,06821192 ! melanin metabolic process GO:0006582 12 8 0,000 0,02758134 0,06813866 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02758134 0,06806555 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02758134 0,06799259 ! macrophage activation GO:0042116 12 8 0,000 0,02758134 0,0679198 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02758134 0,06784715 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02758134 0,06777467 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02758134 0,06770234 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02758134 0,06763016 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02758134 0,06755814 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02758134 0,06748627 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02758134 0,06741455 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02758134 0,06734298 ! ruffle organization GO:0031529 11 8 0,000 0,02758134 0,06727157 ! osteoblast development GO:0002076 13 8 0,000 0,02758134 0,06720031 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02758134 0,0671292 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02758134 0,06705823 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02758134 0,06698742 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02758134 0,06691676 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02758134 0,06684625 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02758134 0,06677588 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02758134 0,06670567 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02758134 0,0666356 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02758134 0,06656568 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02758134 0,0664959 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02758134 0,06642627 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02758134 0,06635679 ! segment specification GO:0007379 10 8 0,000 0,02758134 0,06628745 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02758134 0,06621826 ! cellular extravasation GO:0045123 11 8 0,000 0,02758134 0,06614921 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02758134 0,0660803 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02758134 0,06601154 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02758134 0,06594292 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02758134 0,06587444 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02758134 0,06580611 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02758134 0,06573792 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02758134 0,06566987 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02758134 0,06560195 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02758134 0,06553418 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02758134 0,06546655 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02758134 0,06539906 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02758134 0,06533171 ! icosanoid secretion GO:0032309 12 8 0,000 0,02758134 0,0652645 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02758134 0,06519742 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02758134 0,06513048 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02758134 0,06506368 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02758134 0,06499702 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02758134 0,06493049 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02758134 0,0648641 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02758134 0,06479784 ! sterol catabolic process GO:0016127 9 8 0,000 0,02758134 0,06473172 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02758134 0,06466574 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02758134 0,06459989 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02758134 0,06453417 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02758134 0,06446859 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02758134 0,06440314 ! prophase GO:0051324 11 8 0,000 0,02758134 0,06433782 ! S phase GO:0051320 8 8 0,000 0,02758134 0,06427263 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02758134 0,06420758 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02758134 0,06414266 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02758134 0,06407787 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02758134 0,06401321 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02758134 0,06394868 ! hormone catabolic process GO:0042447 13 8 0,000 0,02758134 0,06388428 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02758134 0,06382001 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02758134 0,06375587 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02758134 0,06369186 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02758134 0,06362797 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02758134 0,06356422 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02758134 0,06350059 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02758134 0,06343709 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02758134 0,06337372 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02758134 0,06331047 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02758134 0,06324735 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02758134 0,06318435 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02758134 0,06312148 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02758134 0,06305874 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02758134 0,06299612 ! regulation of ligase activity GO:0051340 114 75 1,000 0,02823538 0,06442597 ! nuclear import GO:0051170 121 75 1,000 0,02823538 0,06436211 ! gland development GO:0048732 148 77 1,000 0,02964037 0,06749787 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03097596 0,07046954 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03097596 0,07039991 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03097596 0,07033041 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03097596 0,07026105 ! CTP metabolic process GO:0046036 9 9 0,000 0,03097596 0,07019183 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03097596 0,07012275 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03097596 0,07005379 ! GTP metabolic process GO:0046039 9 9 0,000 0,03097596 0,06998498 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03097596 0,0699163 ! social behavior GO:0035176 14 9 0,000 0,03097596 0,06984775 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03097596 0,06977934 ! artery development GO:0060840 19 9 0,000 0,03097596 0,06971107 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03097596 0,06964292 ! response to pain GO:0048265 16 9 0,000 0,03097596 0,06957491 ! protein complex disassembly GO:0043241 17 9 0,000 0,03097596 0,06950703 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03097596 0,06943929 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03097596 0,06937167 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03097596 0,06930419 ! lung alveolus development GO:0048286 17 9 0,000 0,03097596 0,06923684 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03097596 0,06916962 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03097596 0,06910253 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03097596 0,06903557 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03097596 0,06896874 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03097596 0,06890204 ! protein targeting to ER GO:0045047 19 9 0,000 0,03097596 0,06883547 ! T cell selection GO:0045058 18 9 0,000 0,03097596 0,06876902 ! endoderm development GO:0007492 12 9 0,000 0,03097596 0,06870271 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03097596 0,06863652 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03097596 0,06857046 ! arginine catabolic process GO:0006527 10 9 0,000 0,03097596 0,06850453 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03097596 0,06843872 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03097596 0,06837304 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03097596 0,06830749 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03097596 0,06824206 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03097596 0,06817676 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03097596 0,06811158 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03097596 0,06804652 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03097596 0,06798159 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03097596 0,06791679 ! mannose metabolic process GO:0006013 9 9 0,000 0,03097596 0,0678521 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03097596 0,06778754 ! receptor clustering GO:0043113 15 9 0,000 0,03097596 0,06772311 ! epithelial cell development GO:0002064 10 9 0,000 0,03097596 0,06765879 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03097596 0,0675946 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03097596 0,06753053 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03097596 0,06746658 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03097596 0,06740275 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03097596 0,06733904 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03097596 0,06727546 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03097596 0,06721199 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03097596 0,06714864 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03097596 0,06708541 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03097596 0,0670223 ! DNA ligation GO:0006266 14 9 0,000 0,03097596 0,06695931 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03097596 0,06689644 ! response to amine stimulus GO:0014075 13 9 0,000 0,03097596 0,06683369 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03097596 0,06677105 ! erythrocyte development GO:0048821 11 9 0,000 0,03097596 0,06670853 ! renal water homeostasis GO:0003091 14 9 0,000 0,03097596 0,06664613 ! postreplication repair GO:0006301 11 9 0,000 0,03097596 0,06658384 ! mRNA cleavage GO:0006379 13 9 0,000 0,03097596 0,06652167 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03097596 0,06645962 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03097596 0,06639768 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03097596 0,06633586 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03097596 0,06627415 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03097596 0,06621255 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03097596 0,06615108 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03097596 0,06608971 ! acid secretion GO:0046717 14 9 0,000 0,03097596 0,06602846 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03097596 0,06596732 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03097596 0,0659063 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03097596 0,06584539 ! purine base metabolic process GO:0006144 18 9 0,000 0,03097596 0,06578459 ! oocyte differentiation GO:0009994 12 9 0,000 0,03097596 0,0657239 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,03097596 0,06566333 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03097596 0,06560286 ! spleen development GO:0048536 15 9 0,000 0,03097596 0,06554251 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03097596 0,06548227 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03097596 0,06542214 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03097596 0,06536212 ! detection of calcium ion GO:0005513 13 9 0,000 0,03097596 0,06530221 ! blastocyst formation GO:0001825 12 9 0,000 0,03097596 0,06524241 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03097596 0,06518272 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03097596 0,06512313 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03097596 0,06506366 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03097596 0,0650043 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03097596 0,06494504 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03097596 0,06488589 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03097596 0,06482685 ! prepulse inhibition GO:0060134 14 9 0,000 0,03097596 0,06476792 ! embryonic placenta development GO:0001892 12 9 0,000 0,03097596 0,06470909 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03097596 0,06465037 ! insulin secretion GO:0030073 17 9 0,000 0,03097596 0,06459176 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03097596 0,06453325 ! response to nicotine GO:0035094 16 9 0,000 0,03097596 0,06447485 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03097596 0,06441655 ! nucleus localization GO:0051647 15 9 0,000 0,03097596 0,06435836 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03097596 0,06430028 ! T cell activation GO:0042110 134 79 1,000 0,03107282 0,06444318 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,0317992 0,06589024 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,0317992 0,06583093 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,03253229 0,06728801 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,03253229 0,06722755 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,03327202 0,06869447 GO:0060348|bone development, ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03435892 0,0708749 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03435892 0,0708114 ! neuron fate specification GO:0048665 11 10 0,000 0,03435892 0,070748 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03435892 0,07068472 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03435892 0,07062155 ! thyroid gland development GO:0030878 19 10 0,000 0,03435892 0,0705585 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03435892 0,07049556 ! synapsis GO:0007129 13 10 0,000 0,03435892 0,07043273 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03435892 0,07037001 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03435892 0,0703074 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03435892 0,0702449 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03435892 0,07018252 ! sulfate transport GO:0008272 12 10 0,000 0,03435892 0,07012025 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03435892 0,07005808 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,03435892 0,06999603 ! androgen metabolic process GO:0008209 13 10 0,000 0,03435892 0,06993409 ! phospholipid efflux GO:0033700 16 10 0,000 0,03435892 0,06987225 ! hippocampus development GO:0021766 19 10 0,000 0,03435892 0,06981053 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,03435892 0,06974891 ! blood vessel remodeling GO:0001974 21 10 0,000 0,03435892 0,06968741 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03435892 0,06962601 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03435892 0,06956472 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,03435892 0,06950353 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03435892 0,06944246 ! pathogenesis GO:0009405 13 10 0,000 0,03435892 0,06938149 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03435892 0,06932063 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03435892 0,06925988 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03435892 0,06919923 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,03435892 0,06913869 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,03435892 0,06907825 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,03435892 0,06901792 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03435892 0,06895769 ! melanocyte differentiation GO:0030318 15 10 0,000 0,03435892 0,06889757 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03435892 0,06883756 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,03435892 0,06877765 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03435892 0,06871784 ! B cell proliferation GO:0042100 14 10 0,000 0,03435892 0,06865814 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03435892 0,06859854 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,03435892 0,06853904 ! forebrain cell migration GO:0021885 17 10 0,000 0,03435892 0,06847965 ! lipid digestion GO:0044241 15 10 0,000 0,03435892 0,06842036 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03435892 0,06836117 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03435892 0,06830209 ! UV protection GO:0009650 14 10 0,000 0,03435892 0,06824311 ! entry into host cell GO:0030260 20 10 0,000 0,03435892 0,06818423 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03435892 0,06812545 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03435892 0,06806677 ! negative regulation of ossification GO:0030279 19 10 0,000 0,03435892 0,06800819 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03435892 0,06794971 ! regulation of bone resorption GO:0045124 24 10 0,000 0,03435892 0,06789134 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03435892 0,06783306 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03435892 0,06777489 ! regulation of organ growth GO:0046620 11 10 0,000 0,03435892 0,06771681 ! response to dsRNA GO:0043331 18 10 0,000 0,03435892 0,06765883 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03435892 0,06760096 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03435892 0,06754318 ! embryonic axis specification GO:0000578 12 10 0,000 0,03435892 0,0674855 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03435892 0,06742792 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03435892 0,06737043 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03435892 0,06731305 ! cranial nerve development GO:0021545 12 10 0,000 0,03435892 0,06725576 ! fucose catabolic process GO:0019317 16 10 0,000 0,03435892 0,06719857 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,03435892 0,06714148 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03435892 0,06708448 ! protein sumoylation GO:0016925 12 10 0,000 0,03435892 0,06702758 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03435892 0,06697078 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03435892 0,06691407 ! zymogen activation GO:0031638 14 10 0,000 0,03435892 0,06685746 ! salivary gland development GO:0007431 22 10 0,000 0,03435892 0,06680094 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03435892 0,06674453 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03435892 0,0666882 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03435892 0,06663197 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,03435892 0,06657584 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,03435892 0,0665198 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03435892 0,06646385 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03435892 0,066408 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03435892 0,06635224 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03435892 0,06629658 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03435892 0,066241 ! detection of bacterium GO:0016045 10 10 0,000 0,03435892 0,06618553 ! embryonic gut development GO:0048566 11 10 0,000 0,03435892 0,06613014 ! activation of innate immune response GO:0002218 10 10 0,000 0,03435892 0,06607485 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03435892 0,06601965 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03435892 0,06596454 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,03435892 0,06590952 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,03435892 0,0658546 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03435892 0,06579977 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03435892 0,06574502 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,03477121 0,06647862 ! transcription initiation GO:0006352 118 85 1,000 0,03553056 0,06787399 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,03553056 0,06781767 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,03706851 0,07069451 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,03706851 0,07063594 ! rRNA transcription GO:0009303 17 11 0,000 0,03773026 0,07183742 ! respiratory burst GO:0045730 14 11 0,000 0,03773026 0,071778 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03773026 0,07171868 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03773026 0,07165946 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03773026 0,07160034 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,03773026 0,07154131 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,03773026 0,07148238 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03773026 0,07142354 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03773026 0,07136481 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03773026 0,07130617 ! mating GO:0007618 14 11 0,000 0,03773026 0,07124762 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,03773026 0,07118918 ! T cell proliferation GO:0042098 20 11 0,000 0,03773026 0,07113083 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03773026 0,07107257 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,03773026 0,07101441 ! bone resorption GO:0045453 16 11 0,000 0,03773026 0,07095634 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03773026 0,07089837 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,03773026 0,0708405 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03773026 0,07078271 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,03773026 0,07072503 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03773026 0,07066743 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03773026 0,07060993 ! syncytium formation GO:0006949 15 11 0,000 0,03773026 0,07055253 ! plasma membrane organization GO:0007009 18 11 0,000 0,03773026 0,07049521 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03773026 0,07043799 ! focal adhesion formation GO:0048041 24 11 0,000 0,03773026 0,07038087 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03773026 0,07032383 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03773026 0,07026689 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03773026 0,07021004 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03773026 0,07015328 ! adult heart development GO:0007512 11 11 0,000 0,03773026 0,07009661 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,03773026 0,07004004 ! temperature homeostasis GO:0001659 16 11 0,000 0,03773026 0,06998355 ! L-glutamate transport GO:0015813 16 11 0,000 0,03773026 0,06992716 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03773026 0,06987086 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03773026 0,06981465 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03773026 0,06975853 ! stem cell development GO:0048864 29 11 0,000 0,03773026 0,0697025 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,03773026 0,06964655 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03773026 0,0695907 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03773026 0,06953494 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03773026 0,06947927 ! vasoconstriction GO:0042310 15 11 0,000 0,03773026 0,06942369 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03773026 0,06936819 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03773026 0,06931279 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03773026 0,06925747 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03773026 0,06920224 ! ribosome assembly GO:0042255 13 11 0,000 0,03773026 0,0691471 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,03773026 0,06909204 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,03773026 0,06903708 ! chromatin silencing GO:0006342 19 11 0,000 0,03773026 0,0689822 ! nucleosome positioning GO:0016584 13 11 0,000 0,03773026 0,06892741 ! T cell homeostasis GO:0043029 20 11 0,000 0,03773026 0,0688727 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03773026 0,06881809 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,03773026 0,06876356 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03773026 0,06870911 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03773026 0,06865475 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03773026 0,06860048 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03773026 0,06854629 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03773026 0,06849219 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03773026 0,06843818 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03773026 0,06838425 ! male genitalia development GO:0030539 13 11 0,000 0,03773026 0,0683304 ! cholesterol efflux GO:0033344 19 11 0,000 0,03773026 0,06827664 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03773026 0,06822296 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03773026 0,06816937 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03773026 0,06811586 ! germ cell migration GO:0008354 18 11 0,000 0,03773026 0,06806244 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03773026 0,0680091 ! defense response to fungus GO:0050832 12 11 0,000 0,03773026 0,06795584 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03773026 0,06790267 ! lysogeny GO:0030069 18 11 0,000 0,03773026 0,06784958 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,03773026 0,06779657 ! acrosome reaction GO:0007340 13 11 0,000 0,03773026 0,06774364 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03773026 0,0676908 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,03863178 0,06925417 ! reproductive developmental process GO:0003006 127 89 1,000 0,03863178 0,06920023 ! regulation of T cell activation GO:0050863 128 89 1,000 0,03863178 0,06914638 ! leukocyte differentiation GO:0002521 143 90 1,000 0,03942278 0,07050731 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,04102325 0,07331273 ! lactation GO:0007595 20 12 0,000 0,04109003 0,07337505 ! reproductive cellular process GO:0048610 14 12 0,000 0,04109003 0,07331813 ! tRNA modification GO:0006400 14 12 0,000 0,04109003 0,07326129 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04109003 0,07320454 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04109003 0,07314788 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04109003 0,07309131 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04109003 0,07303483 ! non-recombinational repair GO:0000726 19 12 0,000 0,04109003 0,07297843 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04109003 0,07292212 ! peroxisomal transport GO:0043574 21 12 0,000 0,04109003 0,0728659 ! cartilage condensation GO:0001502 18 12 0,000 0,04109003 0,07280976 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04109003 0,07275371 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04109003 0,07269774 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04109003 0,07264186 ! heart looping GO:0001947 15 12 0,000 0,04109003 0,07258607 ! palate development GO:0060021 15 12 0,000 0,04109003 0,07253037 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04109003 0,07247474 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04109003 0,07241921 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04109003 0,07236376 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04109003 0,07230839 ! arginine metabolic process GO:0006525 13 12 0,000 0,04109003 0,07225311 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04109003 0,07219791 ! methionine metabolic process GO:0006555 13 12 0,000 0,04109003 0,0721428 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04109003 0,07208777 ! Golgi organization GO:0007030 18 12 0,000 0,04109003 0,07203282 ! monoamine transport GO:0015844 13 12 0,000 0,04109003 0,07197796 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04109003 0,07192319 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04109003 0,07186849 ! L-amino acid transport GO:0015807 20 12 0,000 0,04109003 0,07181388 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04109003 0,07175935 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04109003 0,07170491 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04109003 0,07165054 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04109003 0,07159626 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04109003 0,07154206 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04109003 0,07148795 ! cerebellum development GO:0021549 13 12 0,000 0,04109003 0,07143391 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04109003 0,07137996 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04109003 0,07132609 ! histone acetylation GO:0016573 23 12 0,000 0,04109003 0,0712723 ! histone methylation GO:0016571 15 12 0,000 0,04109003 0,07121859 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04109003 0,07116496 ! gland morphogenesis GO:0022612 23 12 0,000 0,04109003 0,07111141 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04109003 0,07105794 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,04109003 0,07100456 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04109003 0,07095125 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04109003 0,07089802 ! intestinal absorption GO:0050892 19 12 0,000 0,04109003 0,07084488 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04109003 0,07079181 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04109003 0,07073882 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04109003 0,07068591 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04109003 0,07063308 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04109003 0,07058033 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04109003 0,07052766 ! microspike assembly GO:0030035 23 12 0,000 0,04109003 0,07047507 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04109003 0,07042255 ! response to cold GO:0009409 14 12 0,000 0,04109003 0,07037012 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,04183262 0,07158856 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,04183262 0,07153533 ! angiogenesis GO:0001525 149 95 1,000 0,04346937 0,07427901 ! in utero embryonic development GO:0001701 147 96 1,000 0,04429665 0,07563645 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,04443825 0,07582195 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,04443825 0,07576574 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,04443825 0,07570962 ! cGMP metabolic process GO:0046068 16 13 0,000 0,04443825 0,07565358 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,04443825 0,07559762 ! water transport GO:0006833 17 13 0,000 0,04443825 0,07554175 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,04443825 0,07548596 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,04443825 0,07543025 ! lipid localization GO:0010876 24 13 0,000 0,04443825 0,07537462 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,04443825 0,07531908 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,04443825 0,07526361 ! organelle fusion GO:0048284 28 13 0,000 0,04443825 0,07520823 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,04443825 0,07515293 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,04443825 0,07509771 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,04443825 0,07504257 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,04443825 0,07498752 ! response to hexose stimulus GO:0009746 19 13 0,000 0,04443825 0,07493254 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,04443825 0,07487765 ! glutamate metabolic process GO:0006536 18 13 0,000 0,04443825 0,07482283 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,04443825 0,0747681 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,04443825 0,07471344 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,04443825 0,07465886 ! NAD metabolic process GO:0019674 21 13 0,000 0,04443825 0,07460437 ! exocrine system development GO:0035272 27 13 0,000 0,04443825 0,07454995 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,04443825 0,07449562 ! bone mineralization GO:0030282 15 13 0,000 0,04443825 0,07444136 ! regulation of exocytosis GO:0017157 17 13 0,000 0,04443825 0,07438718 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,04443825 0,07433308 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,04443825 0,07427906 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,04443825 0,07422512 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,04443825 0,07417125 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,04443825 0,07411747 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,04443825 0,07406376 ! genitalia development GO:0048806 15 13 0,000 0,04443825 0,07401013 ! cellular pigmentation GO:0033059 24 13 0,000 0,04443825 0,07395657 ! tissue regeneration GO:0042246 21 13 0,000 0,04443825 0,0739031 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,04443825 0,0738497 ! cofactor transport GO:0051181 19 13 0,000 0,04443825 0,07379638 ! NADP metabolic process GO:0006739 18 13 0,000 0,04443825 0,07374314 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,04443825 0,07368997 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,04443825 0,07363688 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,04443825 0,07358386 ! gas transport GO:0015669 18 13 0,000 0,04443825 0,07353093 ! regulation of RNA stability GO:0043487 28 13 0,000 0,04443825 0,07347806 ! heme biosynthetic process GO:0006783 20 13 0,000 0,04443825 0,07342528 ! regulation of axon extension GO:0030516 23 13 0,000 0,04443825 0,07337257 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,04443825 0,07331993 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,04443825 0,07326737 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,04443825 0,07321489 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,04443825 0,07316248 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,04443825 0,07311015 ! extracellular structure organization GO:0043062 156 99 1,000 0,04681353 0,07696291 ! protein import GO:0017038 156 99 1,000 0,04681353 0,07690794 ! regulation of translation GO:0006417 151 100 1,000 0,047664 0,07824925 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,047664 0,07819343 ! protein localization in organelle GO:0033365 161 100 1,000 0,047664 0,0781377 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,04777498 0,07826386 ! superoxide anion generation GO:0042554 18 14 0,000 0,04777498 0,07820815 ! neuron maturation GO:0042551 21 14 0,000 0,04777498 0,07815253 ! regulation of S phase GO:0033261 18 14 0,000 0,04777498 0,07809698 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,04777498 0,07804152 ! myotube differentiation GO:0014902 21 14 0,000 0,04777498 0,07798613 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,04777498 0,07793082 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,04777498 0,07787559 ! inositol metabolic process GO:0006020 20 14 0,000 0,04777498 0,07782044 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,04777498 0,07776536 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,04777498 0,07771036 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,04777498 0,07765545 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,04777498 0,0776006 ! gene silencing by RNA GO:0031047 20 14 0,000 0,04777498 0,07754584 ! response to cAMP GO:0051591 19 14 0,000 0,04777498 0,07749115 ! limbic system development GO:0021761 25 14 0,000 0,04777498 0,07743654 ! startle response GO:0001964 21 14 0,000 0,04777498 0,07738201 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,04777498 0,07732756 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,04777498 0,07727318 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,04777498 0,07721887 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,04777498 0,07716465 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,04777498 0,0771105 ! glycine metabolic process GO:0006544 22 14 0,000 0,04777498 0,07705642 ! pituitary gland development GO:0021983 23 14 0,000 0,04777498 0,07700242 ! lysosomal transport GO:0007041 20 14 0,000 0,04777498 0,0769485 ! regulation of heart rate GO:0002027 23 14 0,000 0,04777498 0,07689465 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,04777498 0,07684088 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,04777498 0,07678718 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,04777498 0,07673356 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,04777498 0,07668001 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,04777498 0,07662654 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,04777498 0,07657314 ! axon cargo transport GO:0008088 27 14 0,000 0,04777498 0,07651982 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,04777498 0,07646657 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,04777498 0,07641339 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,04777498 0,07636029 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,04777498 0,07630726 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,04777498 0,07625431 ! mRNA splice site selection GO:0006376 26 14 0,000 0,04777498 0,07620143 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,04777498 0,07614862 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,04777498 0,07609588 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,04777498 0,07604322 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,04777498 0,07599063 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,04777498 0,07593812 ! muscle maintenance GO:0046716 19 14 0,000 0,04777498 0,07588567 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,04777498 0,0758333 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,04777498 0,075781 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,04777498 0,07572878 ! cell killing GO:0001906 20 14 0,000 0,04777498 0,07567662 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,04777498 0,07562454 ! cilium assembly GO:0042384 20 14 0,000 0,04777498 0,07557253 ! peptide hormone secretion GO:0030072 23 14 0,000 0,04777498 0,07552059 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,05110025 0,08072154 ! positive regulation of cell size GO:0045793 20 15 0,000 0,05110025 0,08066614 ! metencephalon development GO:0022037 19 15 0,000 0,05110025 0,08061081 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,05110025 0,08055556 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,05110025 0,08050039 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,05110025 0,08044529 ! skin development GO:0043588 25 15 0,000 0,05110025 0,08039026 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,05110025 0,08033531 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,05110025 0,08028044 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,05110025 0,08022564 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,05110025 0,08017092 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,05110025 0,08011627 ! bile acid metabolic process GO:0008206 22 15 0,000 0,05110025 0,08006169 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,05110025 0,08000719 ! adult walking behavior GO:0007628 25 15 0,000 0,05110025 0,07995277 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,05110025 0,07989841 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,05110025 0,07984413 ! myoblast differentiation GO:0045445 27 15 0,000 0,05110025 0,07978993 ! centrosome cycle GO:0007098 16 15 0,000 0,05110025 0,0797358 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,05110025 0,07968174 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,05110025 0,07962775 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,05110025 0,07957384 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,05110025 0,07952 ! cerebral cortex development GO:0021987 29 15 0,000 0,05110025 0,07946624 ! response to osmotic stress GO:0006970 22 15 0,000 0,05110025 0,07941254 ! vesicle coating GO:0006901 25 15 0,000 0,05110025 0,07935892 ! DNA integration GO:0015074 22 15 0,000 0,05110025 0,07930537 ! peptide secretion GO:0002790 27 15 0,000 0,05110025 0,0792519 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,05110025 0,07919849 ! regulation of vasodilation GO:0042312 24 15 0,000 0,05110025 0,07914516 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,05110025 0,0790919 ! neuron recognition GO:0008038 22 15 0,000 0,05110025 0,07903871 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,05110025 0,07898559 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,05110025 0,07893255 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,05110025 0,07887957 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,05110025 0,07882667 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,05110025 0,07877384 ! biomineral formation GO:0031214 18 15 0,000 0,05110025 0,07872108 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,05110025 0,07866838 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,05110025 0,07861576 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,05110025 0,07856321 ! dopamine metabolic process GO:0042417 30 15 0,000 0,05110025 0,07851073 ! organic cation transport GO:0015695 19 15 0,000 0,05110025 0,07845832 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,05110025 0,07840598 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,05110025 0,07835371 ! defense response to virus GO:0051607 27 15 0,000 0,05110025 0,07830151 ! peptide hormone processing GO:0016486 19 15 0,000 0,05110025 0,07824938 ! protein secretion GO:0009306 27 16 0,000 0,05441409 0,0832684 ! hormone secretion GO:0046879 25 16 0,000 0,05441409 0,08321303 ! bone remodeling GO:0046849 24 16 0,000 0,05441409 0,08315774 ! endothelial cell migration GO:0043542 22 16 0,000 0,05441409 0,08310252 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,05441409 0,08304738 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,05441409 0,08299231 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05441409 0,08293731 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,05441409 0,08288239 ! glial cell development GO:0021782 24 16 0,000 0,05441409 0,08282753 ! patterning of blood vessels GO:0001569 24 16 0,000 0,05441409 0,08277275 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,05441409 0,08271805 GO:0042744|hydrogen peroxide catabolic process, ! protein polyubiquitination GO:0000209 26 16 0,000 0,05441409 0,08266341 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,05441409 0,08260885 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,05441409 0,08255436 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,05441409 0,08249994 ! fructose metabolic process GO:0006000 20 16 0,000 0,05441409 0,08244559 ! regulation of protein binding GO:0043393 27 16 0,000 0,05441409 0,08239131 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,05441409 0,08233711 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,05441409 0,08228297 ! protein export from nucleus GO:0006611 24 16 0,000 0,05441409 0,08222891 ! negative regulation of immune response GO:0050777 28 16 0,000 0,05441409 0,08217492 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,05441409 0,082121 ! DNA replication initiation GO:0006270 25 16 0,000 0,05441409 0,08206715 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,05441409 0,08201337 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,05441409 0,08195966 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,05441409 0,08190602 ! diencephalon development GO:0021536 25 16 0,000 0,05441409 0,08185245 ! oogenesis GO:0048477 23 16 0,000 0,05441409 0,08179896 ! neural crest cell migration GO:0001755 24 16 0,000 0,05441409 0,08174553 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,05441409 0,08169217 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,05441409 0,08163888 ! steroid catabolic process GO:0006706 22 16 0,000 0,05441409 0,08158566 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,05441409 0,08153251 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,05441409 0,08147943 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,05441409 0,08142642 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,05441409 0,08137347 ! sperm-egg recognition GO:0035036 16 16 0,000 0,05441409 0,0813206 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,05441409 0,08126779 ! nerve development GO:0021675 18 16 0,000 0,05441409 0,08121506 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,05441409 0,08116239 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,05441409 0,08110979 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,05771655 0,08597672 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,05771655 0,08592107 ! negative regulation of defense response GO:0031348 19 17 0,000 0,05771655 0,0858655 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,05771655 0,08580999 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,05771655 0,08575456 ! glycerol metabolic process GO:0006071 20 17 0,000 0,05771655 0,0856992 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,05771655 0,08564391 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,05771655 0,08558869 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,05771655 0,08553354 ! signal complex assembly GO:0007172 29 17 0,000 0,05771655 0,08547847 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,05771655 0,08542346 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,05771655 0,08536853 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,05771655 0,08531366 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,05771655 0,08525887 ! memory GO:0007613 25 17 0,000 0,05771655 0,08520414 ! keratinization GO:0031424 17 17 0,000 0,05771655 0,08514949 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,05771655 0,08509491 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,05771655 0,0850404 ! retinoid metabolic process GO:0001523 22 17 0,000 0,05771655 0,08498595 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,05771655 0,08493158 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,05771655 0,08487727 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,05771655 0,08482304 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,05771655 0,08476887 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,05771655 0,08471478 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,05771655 0,08466075 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,05771655 0,08460679 ! membrane budding GO:0006900 29 17 0,000 0,05771655 0,0845529 ! heme metabolic process GO:0042168 27 17 0,000 0,05771655 0,08449908 ! actin filament bundle formation GO:0051017 26 17 0,000 0,05771655 0,08444533 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,05771655 0,08439164 ! body fluid secretion GO:0007589 27 17 0,000 0,05771655 0,08433803 ! stem cell differentiation GO:0048863 36 17 0,000 0,05771655 0,08428448 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,05771655 0,084231 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,05771655 0,08417759 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,05771655 0,08412424 ! sensory perception of pain GO:0019233 23 17 0,000 0,05771655 0,08407097 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,05771655 0,08401776 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,05771655 0,08396462 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,05771655 0,08391154 ! synaptogenesis GO:0007416 24 17 0,000 0,05771655 0,08385853 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,05771655 0,08380559 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,05771655 0,08375272 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,05771655 0,08369991 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,05771655 0,08364717 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,05771655 0,08359449 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,05771655 0,08354189 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,05771655 0,08348934 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,06100766 0,08819461 ! positive regulation of translation GO:0045727 28 18 0,000 0,06100766 0,08813921 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,06100766 0,08808388 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,06100766 0,08802862 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,06100766 0,08797343 ! cAMP metabolic process GO:0046058 33 18 0,000 0,06100766 0,08791831 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,06100766 0,08786325 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,06100766 0,08780827 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,06100766 0,08775336 ! axis specification GO:0009798 26 18 0,000 0,06100766 0,08769851 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,06100766 0,08764373 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,06100766 0,08758902 ! pancreas development GO:0031016 26 18 0,000 0,06100766 0,08753438 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,06100766 0,08747981 ! glutamine metabolic process GO:0006541 23 18 0,000 0,06100766 0,08742531 ! response to retinoic acid GO:0032526 25 18 0,000 0,06100766 0,08737087 ! pigmentation during development GO:0048066 31 18 0,000 0,06100766 0,0873165 ! central nervous system neuron development GO:0021954 30 18 0,000 0,06100766 0,0872622 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,06100766 0,08720797 ! fucose metabolic process GO:0006004 26 18 0,000 0,06100766 0,0871538 ! response to fungus GO:0009620 19 18 0,000 0,06100766 0,0870997 ! peptide cross-linking GO:0018149 31 18 0,000 0,06100766 0,08704567 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,06100766 0,0869917 ! heart process GO:0003015 27 18 0,000 0,06100766 0,08693781 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,06100766 0,08688397 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,06100766 0,08683021 ! visual learning GO:0008542 35 18 0,000 0,06100766 0,08677651 ! somitogenesis GO:0001756 24 18 0,000 0,06100766 0,08672288 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,06100766 0,08666931 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,06100766 0,08661581 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,06100766 0,08656238 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,06100766 0,08650901 ! vitamin transport GO:0051180 24 18 0,000 0,06100766 0,08645571 ! hormone transport GO:0009914 27 18 0,000 0,06100766 0,08640247 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,06100766 0,0863493 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,06100766 0,0862962 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,06100766 0,08624316 ! cell-cell recognition GO:0009988 20 18 0,000 0,06100766 0,08619018 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,06100766 0,08613727 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,06100766 0,08608443 ! gut development GO:0048565 26 18 0,000 0,06100766 0,08603165 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,06100766 0,08597893 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,06428747 0,09054573 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,06428747 0,09049031 ! positive regulation of ossification GO:0045778 30 19 0,000 0,06428747 0,09043497 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,06428747 0,09037969 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,06428747 0,09032448 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,06428747 0,09026934 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,06428747 0,09021426 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,06428747 0,09015925 ! regeneration GO:0031099 32 19 0,000 0,06428747 0,09010431 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,06428747 0,09004943 ! response to alkaloid GO:0043279 32 19 0,000 0,06428747 0,08999463 ! sensory perception of taste GO:0050909 23 19 0,000 0,06428747 0,08993989 ! smooth muscle contraction GO:0006939 36 19 0,000 0,06428747 0,08988521 ! peroxisome organization GO:0007031 29 19 0,000 0,06428747 0,0898306 ! digestive system process GO:0022600 30 19 0,000 0,06428747 0,08977606 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,06428747 0,08972158 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,06428747 0,08966717 ! response to vitamin A GO:0033189 26 19 0,000 0,06428747 0,08961283 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,06428747 0,08955855 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,06428747 0,08950434 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,06428747 0,08945019 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,06428747 0,08939611 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,06428747 0,0893421 ! cytolysis GO:0019835 20 19 0,000 0,06428747 0,08928815 ! renal system process GO:0003014 35 19 0,000 0,06428747 0,08923426 ! vasodilation GO:0042311 33 19 0,000 0,06428747 0,08918044 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,06428747 0,08912669 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,06428747 0,08907299 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,06428747 0,08901937 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,06428747 0,08896581 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,06428747 0,08891231 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,06428747 0,08885888 ! sarcomere organization GO:0045214 23 19 0,000 0,06428747 0,08880551 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,06428747 0,0887522 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,06428747 0,08869896 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,06428747 0,08864579 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,06428747 0,08859267 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,06428747 0,08853962 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,06428747 0,08848664 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,06428747 0,08843371 ! protein stabilization GO:0050821 26 19 0,000 0,06428747 0,08838086 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,067556 0,09281888 ! iron ion transport GO:0006826 37 20 0,000 0,067556 0,09276347 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,067556 0,09270812 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,067556 0,09265284 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,067556 0,09259762 ! response to vitamin GO:0033273 29 20 0,000 0,067556 0,09254247 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,067556 0,09248738 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,067556 0,09243237 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,067556 0,09237741 ! spinal cord development GO:0021510 31 20 0,000 0,067556 0,09232252 ! response to ethanol GO:0045471 37 20 0,000 0,067556 0,0922677 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,067556 0,09221294 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,067556 0,09215825 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,067556 0,09210362 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,067556 0,09204906 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,067556 0,09199456 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,067556 0,09194012 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,067556 0,09188575 ! pallium development GO:0021543 38 20 0,000 0,067556 0,09183145 ! DNA modification GO:0006304 28 20 0,000 0,067556 0,0917772 ! collagen fibril organization GO:0030199 45 20 0,000 0,067556 0,09172303 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,067556 0,09166891 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,067556 0,09161486 ! collagen catabolic process GO:0030574 25 20 0,000 0,067556 0,09156088 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,067556 0,09150695 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,067556 0,09145309 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,067556 0,0913993 ! alditol metabolic process GO:0019400 24 20 0,000 0,067556 0,09134557 ! actin filament-based movement GO:0030048 34 20 0,000 0,067556 0,0912919 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,07081331 0,09563747 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,07081331 0,09558134 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,07081331 0,09552529 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,07081331 0,09546929 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,07081331 0,09541336 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,07081331 0,0953575 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,07081331 0,0953017 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,07081331 0,09524597 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,07081331 0,0951903 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,07081331 0,0951347 ! protein amino acid acylation GO:0043543 37 21 0,000 0,07081331 0,09507917 ! vesicle docking GO:0048278 27 21 0,000 0,07081331 0,09502369 ! phototransduction GO:0007602 25 21 0,000 0,07081331 0,09496829 ! visual behavior GO:0007632 39 21 0,000 0,07081331 0,09491294 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,07081331 0,09485767 ! ovarian follicle development GO:0001541 30 21 0,000 0,07081331 0,09480245 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,07081331 0,0947473 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,07081331 0,09469222 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,07081331 0,09463719 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,07081331 0,09458224 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,07081331 0,09452734 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,07081331 0,09447251 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,07081331 0,09441775 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,07081331 0,09436304 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,07081331 0,0943084 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,07081331 0,09425383 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,07081331 0,09419931 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,07081331 0,09414486 ! fatty acid transport GO:0015908 30 21 0,000 0,07081331 0,09409047 ! immunoglobulin production GO:0002377 33 21 0,000 0,07081331 0,09403615 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,07081331 0,09398189 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,07081331 0,09392769 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,07081331 0,09387355 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,07081331 0,09381948 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,07081331 0,09376546 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,07081331 0,09371151 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,07081331 0,09365763 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,07081331 0,0936038 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,07081331 0,09355004 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,07081331 0,09349633 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,07081331 0,09344269 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,07081331 0,09338911 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,07081331 0,09333559 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,07405942 0,09755823 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,07405942 0,09750239 ! viral genome replication GO:0019079 29 22 0,000 0,07405942 0,09744661 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,07405942 0,09739089 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,07405942 0,09733524 ! leukocyte adhesion GO:0007159 38 22 0,000 0,07405942 0,09727965 ! molting cycle process GO:0022404 40 22 0,000 0,07405942 0,09722413 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,07405942 0,09716867 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,07405942 0,09711327 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,07405942 0,09705793 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,07405942 0,09700266 ! vasculogenesis GO:0001570 33 22 0,000 0,07405942 0,09694745 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,07405942 0,09689231 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,07405942 0,09683722 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,07405942 0,0967822 ! lysosome organization GO:0007040 37 22 0,000 0,07405942 0,09672724 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,07405942 0,09667235 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,07405942 0,09661751 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,07405942 0,09656274 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,07405942 0,09650803 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,07405942 0,09645338 ! membrane depolarization GO:0051899 35 22 0,000 0,07405942 0,0963988 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,07405942 0,09634427 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,07405942 0,09628981 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,07405942 0,09623541 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,07405942 0,09618107 ! blastocyst development GO:0001824 37 22 0,000 0,07405942 0,09612679 ! neural tube closure GO:0001843 33 22 0,000 0,07405942 0,09607257 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,07729438 0,10021256 ! neuron fate commitment GO:0048663 32 23 0,000 0,07729438 0,1001561 ! embryonic pattern specification GO:0009880 31 23 0,000 0,07729438 0,10009971 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,07729438 0,10004337 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,07729438 0,09998711 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,07729438 0,0999309 ! vesicle targeting GO:0006903 32 23 0,000 0,07729438 0,09987476 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,07729438 0,09981868 ! osteoblast differentiation GO:0001649 40 23 0,000 0,07729438 0,09976267 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,07729438 0,09970672 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,07729438 0,09965083 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,07729438 0,099595 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,07729438 0,09953924 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,07729438 0,09948353 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,07729438 0,0994279 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,07729438 0,09937232 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,07729438 0,0993168 ! cell fate determination GO:0001709 45 23 0,000 0,07729438 0,09926135 ! pentose metabolic process GO:0019321 31 23 0,000 0,07729438 0,09920596 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,07729438 0,09915063 ! spermatid development GO:0007286 33 23 0,000 0,07729438 0,09909536 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,07729438 0,09904015 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,07729438 0,09898501 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,07729438 0,09892993 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,07729438 0,0988749 ! telomere organization GO:0032200 32 23 0,000 0,07729438 0,09881994 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,07729438 0,09876504 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,07729438 0,0987102 ! regulation of amine transport GO:0051952 38 23 0,000 0,07729438 0,09865543 ! liver development GO:0001889 40 23 0,000 0,07729438 0,09860071 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,08051822 0,10265627 ! initiation of viral infection GO:0019059 42 24 0,000 0,08051822 0,1025994 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,08051822 0,10254259 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,08051822 0,10248584 ! superoxide metabolic process GO:0006801 32 24 0,000 0,08051822 0,10242915 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,08051822 0,10237253 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,08051822 0,10231597 ! fat cell differentiation GO:0045444 37 24 0,000 0,08051822 0,10225948 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,08051822 0,10220304 ! sperm motility GO:0030317 27 24 0,000 0,08051822 0,10214667 ! vacuole organization GO:0007033 39 24 0,000 0,08051822 0,10209036 ! receptor metabolic process GO:0043112 37 24 0,000 0,08051822 0,10203411 ! neural crest cell development GO:0014032 39 24 0,000 0,08051822 0,10197792 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,08051822 0,1019218 ! primary neural tube formation GO:0014020 35 24 0,000 0,08051822 0,10186574 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,08051822 0,10180974 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,08051822 0,1017538 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,08051822 0,10169792 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,08051822 0,1016421 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,08373098 0,10563975 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,08373098 0,10558183 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,08373098 0,10552398 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,08373098 0,10546619 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,08373098 0,10540846 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,08373098 0,1053508 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,08373098 0,1052932 ! peptide transport GO:0015833 43 25 0,000 0,08373098 0,10523566 ! male gonad development GO:0008584 33 25 0,000 0,08373098 0,10517819 ! iron ion homeostasis GO:0055072 39 25 0,000 0,08373098 0,10512078 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,08373098 0,10506343 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,08373098 0,10500614 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,08373098 0,10494892 ! phospholipid transport GO:0015914 35 25 0,000 0,08373098 0,10489176 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,08373098 0,10483466 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,08373098 0,10477762 ! detection of light stimulus GO:0009583 30 25 0,000 0,08373098 0,10472064 ! leukocyte proliferation GO:0070661 39 25 0,000 0,08373098 0,10466373 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,0869327 0,10860685 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,0869327 0,10854789 ! translational initiation GO:0006413 43 26 0,000 0,0869327 0,10848899 ! circadian rhythm GO:0007623 42 26 0,000 0,0869327 0,10843016 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,0869327 0,10837139 ! post-embryonic development GO:0009791 42 26 0,000 0,0869327 0,10831269 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,0869327 0,10825404 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,0869327 0,10819546 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,0869327 0,10813695 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,0869327 0,1080785 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,0869327 0,10802011 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,0869327 0,10796178 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,09012342 0,11186393 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,09012342 0,11180359 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,09012342 0,11174332 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,09012342 0,11168311 ! membrane docking GO:0022406 39 27 0,000 0,09012342 0,11162297 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,09012342 0,1115629 ! catechol metabolic process GO:0009712 43 27 0,000 0,09012342 0,11150288 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,09012342 0,11144294 ! acute-phase response GO:0006953 42 27 0,000 0,09012342 0,11138305 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,09012342 0,11132323 ! myofibril assembly GO:0030239 36 27 0,000 0,09012342 0,11126348 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,09012342 0,11120379 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,09012342 0,11114416 ! natural killer cell activation GO:0030101 35 27 0,000 0,09012342 0,1110846 ! lipid oxidation GO:0034440 38 27 0,000 0,09012342 0,1110251 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,09012342 0,11096566 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,09012342 0,11090629 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,09012342 0,11084698 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,09012342 0,11078774 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,09012342 0,11072856 ! gene silencing GO:0016458 41 27 0,000 0,09012342 0,11066944 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,09330316 0,11451295 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,09330316 0,11445188 ! phenol metabolic process GO:0018958 44 28 0,000 0,09330316 0,11439087 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,09330316 0,11432993 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,09330316 0,11426905 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,09330316 0,11420824 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,09330316 0,11414749 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,09330316 0,1140868 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,09330316 0,11402618 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,09330316 0,11396563 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,09330316 0,11390514 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,09330316 0,11384471 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,09330316 0,11378435 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,09330316 0,11372405 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,09330316 0,11366381 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,09330316 0,11360364 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,09330316 0,11354353 ! mesoderm formation GO:0001707 46 28 0,000 0,09330316 0,11348349 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,09330316 0,11342351 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,09330316 0,11336359 ! BMP signaling pathway GO:0030509 40 28 0,000 0,09330316 0,11330374 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,09330316 0,11324394 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,09330316 0,11318422 ! neural tube formation GO:0001841 41 28 0,000 0,09330316 0,11312455 ! placenta development GO:0001890 37 28 0,000 0,09330316 0,11306495 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,09647198 0,11684337 ! regulation of innate immune response GO:0045088 38 29 0,000 0,09647198 0,11678187 ! ovulation cycle process GO:0022602 41 29 0,000 0,09647198 0,11672044 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,09647198 0,11665907 ! protein targeting to membrane GO:0006612 53 29 0,000 0,09647198 0,11659777 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,09647198 0,11653653 ! mismatch repair GO:0006298 34 29 0,000 0,09647198 0,11647536 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,09647198 0,11641425 ! muscle cell development GO:0055001 38 29 0,000 0,09647198 0,1163532 ! formation of primary germ layer GO:0001704 48 29 0,000 0,09647198 0,11629222 ! telencephalon development GO:0021537 52 29 0,000 0,09647198 0,1162313 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,09647198 0,11617045 ! eye morphogenesis GO:0048592 51 29 0,000 0,09647198 0,11610966 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,09647198 0,11604893 ! tissue homeostasis GO:0001894 42 29 0,000 0,09647198 0,11598827 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,0996299 0,11972245 ! collagen metabolic process GO:0032963 40 30 0,000 0,0996299 0,11965993 ! organic anion transport GO:0015711 51 30 0,000 0,0996299 0,11959748 ! cholesterol transport GO:0030301 46 30 0,000 0,0996299 0,11953509 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,0996299 0,11947277 ! spliceosome assembly GO:0000245 49 30 0,000 0,0996299 0,11941051 ! spindle organization GO:0007051 37 30 0,000 0,0996299 0,11934832 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,0996299 0,11928619 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,0996299 0,11922413 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,0996299 0,11916213 ! ceramide metabolic process GO:0006672 43 30 0,000 0,0996299 0,11910019 ! ovulation cycle GO:0042698 43 30 0,000 0,0996299 0,11903832 ! hindbrain development GO:0030902 45 30 0,000 0,0996299 0,11897652 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,0996299 0,11891478 ! adult locomotory behavior GO:0008344 47 30 0,000 0,0996299 0,1188531 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,0996299 0,11879148 ! response to heat GO:0009408 41 30 0,000 0,0996299 0,11872993 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,0996299 0,11866845 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,0996299 0,11860702 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,10277697 0,12229023 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,10277697 0,122227 ! odontogenesis GO:0042476 50 31 0,000 0,10277697 0,12216384 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,10277697 0,12210073 ! segmentation GO:0035282 41 31 0,000 0,10277697 0,1220377 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,10277697 0,12197473 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,10277697 0,12191182 ! metanephros development GO:0001656 58 31 0,000 0,10277697 0,12184898 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,10277697 0,1217862 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,10277697 0,12172349 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,10277697 0,12166084 ! RNA modification GO:0009451 40 31 0,000 0,10277697 0,12159826 ! regulation of muscle development GO:0048634 48 32 0,000 0,10591321 0,12524441 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,10591321 0,12518005 ! meiosis I GO:0007127 52 32 0,000 0,10591321 0,12511576 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,10591321 0,12505153 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,10591321 0,12498737 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,10591321 0,12492327 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 48 32 0,000 0,10591321 0,12485924 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,10591321 0,12479528 ! cytokine production GO:0001816 44 32 0,000 0,10591321 0,12473138 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,10591321 0,12466755 ! vesicle localization GO:0051648 47 32 0,000 0,10591321 0,12460378 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,10903867 0,12821521 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,10903867 0,12814969 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,10903867 0,12808424 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,10903867 0,12801886 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,10903867 0,12795354 ! ear morphogenesis GO:0042471 42 33 0,000 0,10903867 0,12788829 ! actomyosin structure organization GO:0031032 43 33 0,000 0,10903867 0,12782311 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,10903867 0,12775799 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,10903867 0,12769294 ! nucleus organization GO:0006997 49 33 0,000 0,10903867 0,12762796 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,10903867 0,12756304 ! female gonad development GO:0008585 49 33 0,000 0,10903867 0,12749819 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,10903867 0,12743341 ! positive regulation of cell development GO:0010720 54 33 0,000 0,10903867 0,12736869 ! lipid homeostasis GO:0055088 55 33 0,000 0,10903867 0,12730403 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,10903867 0,12723944 ! regulation of proteolysis GO:0030162 50 33 0,000 0,10903867 0,12717492 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,10903867 0,12711046 ! cytokinesis GO:0000910 52 33 0,000 0,10903867 0,12704607 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,10903867 0,12698174 ! mRNA catabolic process GO:0006402 48 34 0,000 0,11215338 0,13054291 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,11215338 0,13047688 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,11215338 0,13041091 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,11215338 0,13034502 ! feeding behavior GO:0007631 45 34 0,000 0,11215338 0,13027918 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,11215338 0,13021342 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,11215338 0,13014772 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,11215338 0,13008209 ! neuron migration GO:0001764 46 34 0,000 0,11215338 0,13001652 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,11215338 0,12995103 ! female gamete generation GO:0007292 43 34 0,000 0,11215338 0,12988559 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,11215338 0,12982022 ! polyol metabolic process GO:0019751 44 34 0,000 0,11215338 0,12975492 ! aerobic respiration GO:0009060 47 34 0,000 0,11215338 0,12968969 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,11215338 0,12962452 ! embryonic organ development GO:0048568 45 34 0,000 0,11215338 0,12955941 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,11215338 0,12949437 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,11525739 0,13301154 ! Notch signaling pathway GO:0007219 56 35 0,000 0,11525739 0,13294483 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,11525739 0,13287819 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,11525739 0,13281162 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,11525739 0,13274511 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,11525739 0,13267867 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,11525739 0,1326123 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,11525739 0,132546 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,11525739 0,13247976 ! pigment metabolic process GO:0042440 61 35 0,000 0,11525739 0,13241358 ! protein homooligomerization GO:0051260 52 35 0,000 0,11525739 0,13234747 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,11835072 0,13583166 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,11835072 0,13576391 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,11835072 0,13569624 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,11835072 0,13562862 ! negative regulation of binding GO:0051100 58 36 0,000 0,11835072 0,13556108 ! organic ether metabolic process GO:0018904 46 36 0,000 0,11835072 0,1354936 ! tissue remodeling GO:0048771 62 36 0,000 0,11835072 0,13542619 ! neural tube development GO:0021915 50 36 0,000 0,11835072 0,13535885 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,11835072 0,13529157 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,11835072 0,13522437 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,11835072 0,13515722 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,11835072 0,13509015 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,12143341 0,1385401 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,12143341 0,13847141 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,12143341 0,13840279 ! learning GO:0007612 67 37 0,000 0,12143341 0,13833424 ! ion transmembrane transport GO:0034220 56 37 0,000 0,12143341 0,13826576 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,12143341 0,13819734 ! amino acid activation GO:0043038 52 37 0,000 0,12143341 0,138129 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,12143341 0,13806072 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,12450549 0,14148352 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,12450549 0,14141365 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,12450549 0,14134385 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,12450549 0,14127412 ! phagocytosis GO:0006909 60 38 0,000 0,12450549 0,14120445 ! mesenchymal cell development GO:0014031 64 38 0,000 0,12450549 0,14113486 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,12450549 0,14106534 ! maintenance of location in cell GO:0051651 69 38 0,000 0,12450549 0,14099588 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,12756701 0,1443918 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,12756701 0,14432077 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,12756701 0,14424982 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,12756701 0,14417893 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,12756701 0,14410812 ! male sex differentiation GO:0046661 53 39 0,000 0,12756701 0,14403737 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,12756701 0,1439667 ! chromatin remodeling GO:0006338 68 39 0,000 0,12756701 0,14389609 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,12756701 0,14382555 ! developmental growth GO:0048589 62 39 0,000 0,12756701 0,14375509 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,130618 0,14712116 ! response to calcium ion GO:0051592 58 40 0,000 0,130618 0,14704915 ! regulation of tube size GO:0035150 60 40 0,000 0,130618 0,14697721 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,130618 0,14690533 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,130618 0,14683353 ! inner ear development GO:0048839 57 40 0,000 0,130618 0,1467618 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,130618 0,14669014 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,130618 0,14661855 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,130618 0,14654703 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,1336585 0,1498852 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,1336585 0,14981216 ! glucose transport GO:0015758 52 41 0,000 0,1336585 0,14973918 ! endosome transport GO:0016197 71 41 0,000 0,1336585 0,14966628 ! striated muscle contraction GO:0006941 62 41 0,000 0,1336585 0,14959345 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,1336585 0,14952069 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,1336585 0,149448 ! biopolymer methylation GO:0043414 62 41 0,000 0,1336585 0,14937539 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,13668853 0,15268753 ! cellular component disassembly GO:0022411 64 42 0,000 0,13668853 0,15261341 ! hexose transport GO:0008645 54 42 0,000 0,13668853 0,15253936 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,13668853 0,15246539 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,13668853 0,15239148 ! excretion GO:0007588 63 42 0,000 0,13668853 0,15231765 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,13668853 0,15224389 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,13668853 0,1521702 ! regulation of cell shape GO:0008360 78 42 0,000 0,13668853 0,15209658 ! positive regulation of binding GO:0051099 59 43 0,000 0,13970814 0,1553814 ! neuromuscular process GO:0050905 79 43 0,000 0,13970814 0,1553063 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,13970814 0,15523127 ! tRNA processing GO:0008033 49 43 0,000 0,13970814 0,15515631 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,13970814 0,15508143 ! vesicle organization GO:0016050 79 43 0,000 0,13970814 0,15500662 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,13970814 0,15493188 ! methylation GO:0032259 64 43 0,000 0,13970814 0,15485722 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,14271736 0,15811654 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,14271736 0,15804041 ! glycolysis GO:0006096 53 44 0,000 0,14271736 0,15796436 ! regulation of ion transport GO:0043269 57 44 0,000 0,14271736 0,15788838 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,14271736 0,15781247 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,14271736 0,15773663 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,14271736 0,15766087 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,14271736 0,15758518 ! RNA catabolic process GO:0006401 64 45 0,000 0,14571623 0,16081926 ! regulation of translational initiation GO:0006446 64 45 0,000 0,14571623 0,16074212 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,14571623 0,16066507 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,14571623 0,16058808 ! cell recognition GO:0008037 58 45 0,000 0,14571623 0,16051117 ! cell maturation GO:0048469 60 45 0,000 0,14571623 0,16043434 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,14870478 0,16364641 ! cell redox homeostasis GO:0045454 63 46 0,000 0,14870478 0,16356814 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,14870478 0,16348996 ! histone modification GO:0016570 68 46 0,000 0,14870478 0,16341184 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,14870478 0,16333381 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,15168304 0,16652554 ! viral infectious cycle GO:0019058 71 47 0,000 0,15168304 0,16644609 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,15168304 0,16636671 ! endocrine system development GO:0035270 83 47 0,000 0,15168304 0,16628741 ! covalent chromatin modification GO:0016569 75 47 0,000 0,15168304 0,16620819 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,15168304 0,16612905 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,15168304 0,16604997 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,15168304 0,16597098 ! chloride transport GO:0006821 67 48 0,000 0,15465106 0,1691381 ! response to temperature stimulus GO:0009266 62 48 0,000 0,15465106 0,16905771 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,15465106 0,1689774 ! gastrulation GO:0007369 73 48 0,000 0,15465106 0,16889717 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,15465106 0,16881701 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,15465106 0,16873692 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,15465106 0,16865691 ! regulation of endocytosis GO:0030100 63 48 0,000 0,15465106 0,16857698 ! nuclear export GO:0051168 69 48 0,000 0,15465106 0,16849712 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,15465106 0,16841734 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,15760886 0,1715572 ! sensory perception of smell GO:0007608 61 49 0,000 0,15760886 0,17147605 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,15760886 0,17139497 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,15760886 0,17131397 ! germ cell development GO:0007281 68 49 0,000 0,15760886 0,17123305 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,15760886 0,1711522 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,15760886 0,17107143 ! maintenance of location GO:0051235 84 49 0,000 0,15760886 0,17099074 ! regulation of actin filament length GO:0030832 72 50 0,000 0,16055648 0,1741065 ! ear development GO:0043583 72 50 0,000 0,16055648 0,17402446 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,16055648 0,17394249 ! proton transport GO:0015992 75 50 0,000 0,16055648 0,17386059 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,16055648 0,17377877 ! positive regulation of secretion GO:0051047 71 51 0,000 0,16349395 0,17687492 ! hydrogen transport GO:0006818 77 51 0,000 0,16349395 0,17679177 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,16349395 0,17670869 ! adult behavior GO:0030534 80 51 0,000 0,16349395 0,17662569 ! transition metal ion transport GO:0000041 74 52 0,000 0,16642131 0,17970377 ! regulation of cellular component size GO:0032535 74 52 0,000 0,16642131 0,17961944 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,16642131 0,17953519 ! establishment of organelle localization GO:0051656 85 52 0,000 0,16642131 0,17945102 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,1693386 0,18251114 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,1693386 0,18242566 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,1693386 0,18234025 ! kidney development GO:0001822 90 53 0,000 0,1693386 0,18225493 ! cell projection assembly GO:0030031 76 53 0,000 0,1693386 0,18216968 ! amino acid transport GO:0006865 84 54 0,000 0,17224584 0,18521058 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,17224584 0,18512404 ! glucose catabolic process GO:0006007 66 54 0,000 0,17224584 0,18503757 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,17224584 0,18495119 ! detection of external stimulus GO:0009581 66 54 0,000 0,17224584 0,18486488 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,17224584 0,18477866 ! exocytosis GO:0006887 74 55 0,000 0,17514308 0,18779911 ! mesoderm development GO:0007498 76 55 0,000 0,17514308 0,18771159 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,17514308 0,18762416 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,17514308 0,18753682 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,17803034 0,19053968 ! carbohydrate transport GO:0008643 74 57 0,000 0,18090766 0,19352912 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,18090766 0,19343915 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,18090766 0,19334926 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,18090766 0,19325946 ! camera-type eye development GO:0043010 88 57 0,000 0,18090766 0,19316974 ! secondary metabolic process GO:0019748 84 57 0,000 0,18090766 0,1930801 ! developmental maturation GO:0021700 75 57 0,000 0,18090766 0,19299054 ! gonad development GO:0008406 79 57 0,000 0,18090766 0,19290107 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,18377507 0,19586777 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,18377507 0,19577705 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,1866326 0,19872916 ! actin filament organization GO:0007015 95 59 0,000 0,1866326 0,1986372 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,1866326 0,19854532 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,1866326 0,19845353 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,1894803 0,20138849 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,1894803 0,20129547 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,1894803 0,20120253 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,1894803 0,20110969 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,1894803 0,20101692 ! meiosis GO:0007126 96 61 0,000 0,19231819 0,20393353 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,19231819 0,20383956 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,19231819 0,20374566 ! urogenital system development GO:0001655 101 61 0,000 0,19231819 0,20365186 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,19231819 0,20355814 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,19231819 0,20346451 ! extracellular matrix organization GO:0030198 103 61 0,000 0,19231819 0,20337096 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,19231819 0,2032775 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,1951463 0,20617203 ! neurotransmitter transport GO:0006836 81 62 0,000 0,1951463 0,20607736 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,1951463 0,20598279 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,1951463 0,2058883 ! meiotic cell cycle GO:0051321 97 62 0,000 0,1951463 0,2057939 ! organelle localization GO:0051640 96 62 0,000 0,1951463 0,20569959 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,19796468 0,20857479 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,19796468 0,20847929 ! appendage morphogenesis GO:0035107 93 64 0,000 0,20077334 0,21134036 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,20077334 0,21124368 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,20077334 0,21114709 ! hexose catabolic process GO:0019320 82 64 0,000 0,20077334 0,21105059 ! adaptive immune response GO:0002250 94 64 0,000 0,20077334 0,21095418 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,20357234 0,21379743 ! appendage development GO:0048736 94 65 0,000 0,20357234 0,21369985 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,20357234 0,21360236 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,20357234 0,21350496 ! activation of immune response GO:0002253 83 65 0,000 0,20357234 0,21340764 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,20636168 0,2162332 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,20636168 0,21613473 ! antigen processing and presentation GO:0019882 96 66 0,000 0,20636168 0,21603636 ! regulation of immune effector process GO:0002697 101 66 0,000 0,20636168 0,21593807 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,20914142 0,21874728 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,20914142 0,21864785 ! acute inflammatory response GO:0002526 92 68 0,000 0,21191159 0,22144327 ! learning or memory GO:0007611 123 68 0,000 0,21191159 0,22134271 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,21191159 0,22124224 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,21191159 0,22114185 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,21191159 0,22104156 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,21191159 0,22094136 ! rhythmic process GO:0048511 105 68 0,000 0,21191159 0,22084125 ! inorganic anion transport GO:0015698 93 68 0,000 0,21191159 0,22074123 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,2146722 0,22351565 ! response to metal ion GO:0010038 103 70 0,000 0,21742331 0,22627765 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,21742331 0,22617531 ! humoral immune response GO:0006959 86 70 0,000 0,21742331 0,22607306 ! eye development GO:0001654 111 70 0,000 0,21742331 0,2259709 ! amine transport GO:0015837 101 70 0,000 0,21742331 0,22586884 ! muscle cell differentiation GO:0042692 104 71 0,000 0,22016493 0,2286137 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,22016493 0,22851054 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,22016493 0,22840746 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,22016493 0,22830448 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,22289711 0,23103351 ! regulation of blood pressure GO:0008217 107 73 0,000 0,22561987 0,23375032 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,22561987 0,23364507 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,22561987 0,23353992 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,22833325 0,23624223 ! digestion GO:0007586 97 74 0,000 0,22833325 0,236136 ! response to inorganic substance GO:0010035 115 75 0,000 0,23103727 0,23882505 ! response to nutrient GO:0007584 104 75 0,000 0,23103727 0,23871776 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,23103727 0,23861057 ! amine biosynthetic process GO:0009309 97 76 0,000 0,23373198 0,24128526 ! tRNA metabolic process GO:0006399 95 76 0,000 0,23373198 0,24117701 ! response to unfolded protein GO:0006986 99 76 0,000 0,23373198 0,24106886 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,23373198 0,2409608 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,2364174 0,24362008 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,2364174 0,24351098 ! regulation of DNA binding GO:0051101 119 77 0,000 0,2364174 0,24340197 ! sex differentiation GO:0007548 105 77 0,000 0,2364174 0,24329307 ! protein ubiquitination GO:0016567 125 77 0,000 0,2364174 0,24318426 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,2364174 0,24307555 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,2364174 0,24296694 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,2364174 0,24285842 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,23909355 0,24549785 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,23909355 0,2453883 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,24176049 0,24801477 ! cellular respiration GO:0045333 107 79 0,000 0,24176049 0,2479042 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,24176049 0,24779372 ! regulation of lyase activity GO:0051339 133 79 0,000 0,24176049 0,24768335 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,24176049 0,24757307 ! chromatin assembly GO:0031497 102 80 0,000 0,24441822 0,25018332 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,24441822 0,25007203 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,24441822 0,24996083 ! forebrain development GO:0030900 131 80 0,000 0,24441822 0,24984974 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,2470668 0,25244497 ! mRNA transport GO:0051028 121 81 0,000 0,2470668 0,25233288 ! response to protein stimulus GO:0051789 111 81 0,000 0,2470668 0,25222088 ! regulation of neurological system process GO:0031644 122 81 0,000 0,2470668 0,25210898 ! vitamin metabolic process GO:0006766 103 81 0,000 0,2470668 0,25199718 ! detection of stimulus GO:0051606 108 82 0,000 0,24970624 0,2545764 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,25233658 0,25714406 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,25233658 0,25703017 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,25495785 0,25958524 ! sterol metabolic process GO:0016125 120 84 0,000 0,25495785 0,25947038 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,25757008 0,26201291 ! rRNA metabolic process GO:0016072 107 85 0,000 0,25757008 0,26189707 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,25757008 0,26178134 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,2601733 0,26431033 ! nucleosome organization GO:0034728 114 87 0,000 0,26276754 0,26682797 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,26276754 0,26671021 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,26276754 0,26659257 ! female pregnancy GO:0007565 130 87 0,000 0,26276754 0,26647502 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,26535284 0,26897819 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,26535284 0,2688597 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,26535284 0,26874131 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,26535284 0,26862303 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,26535284 0,26850485 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,26792921 0,27099261 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,26792921 0,27087349 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,2704967 0,27334904 ! hormone metabolic process GO:0042445 121 90 0,000 0,2704967 0,27322899 ! RNA localization GO:0006403 135 91 0,000 0,27305533 0,27569239 ! ATP metabolic process GO:0046034 137 91 0,000 0,27305533 0,27557142 ! response to virus GO:0009615 122 91 0,000 0,27305533 0,27545055 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,27560513 0,27790083 ! positive regulation of immune response GO:0050778 121 92 0,000 0,27560513 0,27777906 ! DNA recombination GO:0006310 146 92 0,000 0,27560513 0,27765738 ! sulfur metabolic process GO:0006790 118 92 0,000 0,27560513 0,27753582 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,27814614 0,27997204 ! electron transport chain GO:0022900 123 94 0,000 0,28067838 0,28239732 ! response to oxidative stress GO:0006979 141 94 0,000 0,28067838 0,28227384 ! regulation of binding GO:0051098 151 95 0,000 0,28320188 0,2846872 ! carboxylic acid transport GO:0046942 147 95 0,000 0,28320188 0,28456283 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,28571667 0,28696434 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,28571667 0,28683908 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,28571667 0,28671393 ! protein maturation GO:0051604 129 96 0,000 0,28571667 0,28658889 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,28822278 0,28897663 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,28822278 0,28885072 ! calcium ion transport GO:0006816 167 99 0,000 0,29320909 0,29371991 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,29568934 0,29607553 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,29568934 0,29594669 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,29568934 0,29581796 ! divalent metal ion transport GO:0070838 171 100 0,000 0,29568934 0,29568934