pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6581-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! elastic fiber assembly GO:0048251 13 9 6,000 1,461E-13 3,359E-10 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 8,000 1,311E-10 1,507E-07 ! collagen metabolic process GO:0032963 40 30 7,000 1,75E-10 1,342E-07 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 7,000 4,059E-10 2,334E-07 ! multicellular organismal metabolic process GO:0044236 50 39 7,000 1,718E-09 7,905E-07 ! interphase of mitotic cell cycle GO:0051329 156 86 9,000 5,046E-09 1,934E-06 ! interphase GO:0051325 159 88 9,000 6,335E-09 2,081E-06 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 4,000 1,332E-08 3,829E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 7,000 1,624E-08 4,149E-06 ! extracellular structure organization GO:0043062 156 99 9,000 2,01E-08 4,622E-06 ! extracellular matrix organization GO:0030198 103 61 7,000 6,96E-08 1,455E-05 ! aging GO:0007568 79 52 6,000 3,927E-07 7,527E-05 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 3,000 4,261E-07 7,539E-05 ! regulation of intracellular protein transport GO:0033157 59 35 5,000 6,239E-07 1,025E-04 ! meiosis GO:0007126 96 61 6,000 1,197E-06 1,835E-04 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of cell-matrix adhesion GO:0001953 27 10 3,000 1,261E-06 1,812E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! meiotic cell cycle GO:0051321 97 62 6,000 1,339E-06 1,812E-04 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 5,000 1,914E-06 2,446E-04 ! embryonic skeletal system development GO:0048706 56 42 5,000 1,914E-06 2,318E-04 ! positive regulation of cell cycle GO:0045787 77 45 5,000 2,907E-06 3,343E-04 ! regulation of mRNA stability GO:0043488 27 12 3,000 2,93E-06 3,209E-04 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 4,000 3,095E-06 3,236E-04 ! regulation of RNA stability GO:0043487 28 13 3,000 4,203E-06 4,203E-04 ! regulation of angiogenesis GO:0045765 94 49 5,000 4,846E-06 4,644E-04 ! regulation of intracellular transport GO:0032386 78 49 5,000 4,846E-06 4,458E-04 ! negative regulation of growth GO:0045926 123 75 6,000 4,902E-06 4,337E-04 ! embryonic skeletal system morphogenesis GO:0048704 42 30 4,000 6,514E-06 5,549E-04 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 7,013E-06 5,761E-04 ! cranial nerve morphogenesis GO:0021602 6 5 2,000 7,013E-06 5,562E-04 ! skeletal system morphogenesis GO:0048705 78 53 5,000 7,723E-06 5,921E-04 ! regulation of cell cycle process GO:0010564 122 81 6,000 8,211E-06 6,092E-04 ! cell cycle arrest GO:0007050 150 86 6,000 1,222E-05 8,784E-04 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 4,000 1,236E-05 8,612E-04 ! dorsal/ventral pattern formation GO:0009953 44 34 4,000 1,236E-05 8,359E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 3,000 1,36E-05 8,939E-04 ! male meiosis GO:0007140 7 6 2,000 1,393E-05 8,902E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 1,393E-05 8,661E-04 ! ER overload response GO:0006983 7 6 2,000 1,393E-05 8,433E-04 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 1,393E-05 8,217E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 1,393E-05 8,012E-04 ! negative regulation of cell growth GO:0030308 106 62 5,000 1,935E-05 1,086E-03 ! positive regulation of intracellular transport GO:0032388 29 19 3,000 2,184E-05 1,196E-03 ! negative regulation of cell size GO:0045792 108 64 5,000 2,325E-05 1,244E-03 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 2,422E-05 1,266E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 2,798E-05 1,43E-03 ! double-strand break repair GO:0006302 67 40 4,000 2,798E-05 1,399E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 3,85E-05 1,884E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 3,85E-05 1,845E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 3,85E-05 1,807E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 3,85E-05 1,771E-03 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 3,85E-05 1,736E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 4,037E-05 1,786E-03 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 3,000 4,853E-05 2,106E-03 ! negative regulation of DNA replication GO:0008156 35 23 3,000 4,853E-05 2,067E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 4,853E-05 2,029E-03 ! response to UV GO:0009411 75 46 4,000 5,581E-05 2,292E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 5,783E-05 2,333E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 3,000 5,783E-05 2,293E-03 ! regulation of protein transport GO:0051223 114 76 5,000 6,206E-05 2,419E-03 GO:0070201|regulation of establishment of protein localization, ! gland development GO:0048732 148 77 5,000 6,681E-05 2,561E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 6,836E-05 2,578E-03 GO:0045936|negative regulation of phosphate metabolic process, ! thyroid gland development GO:0030878 19 10 2,000 8,142E-05 3,02E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 8,142E-05 2,972E-03 ! response to X-ray GO:0010165 16 10 2,000 8,142E-05 2,926E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 8,142E-05 2,881E-03 ! cranial nerve development GO:0021545 12 10 2,000 8,142E-05 2,837E-03 ! embryonic gut development GO:0048566 11 10 2,000 8,142E-05 2,795E-03 ! forebrain development GO:0030900 131 80 5,000 8,282E-05 2,801E-03 ! positive regulation of cell migration GO:0030335 92 51 4,000 9,225E-05 3,075E-03 ! kidney development GO:0001822 90 53 4,000 1,111E-04 3,65E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 1,112E-04 3,603E-03 ! double-strand break repair via homologous recombination GO:0000724 16 11 2,000 1,112E-04 3,553E-03 GO:0000725|recombinational repair, ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 1,112E-04 3,504E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,112E-04 3,456E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of DNA metabolic process GO:0051052 135 85 5,000 1,162E-04 3,563E-03 ! anterior/posterior pattern formation GO:0009952 124 85 5,000 1,162E-04 3,516E-03 ! regulation of protein localization GO:0032880 132 85 5,000 1,162E-04 3,47E-03 ! regulation of protein import into nucleus GO:0042306 53 29 3,000 1,248E-04 3,68E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 1,447E-04 4,213E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,473E-04 4,235E-03 ! mammary gland development GO:0030879 57 31 3,000 1,631E-04 4,63E-03 ! metanephros development GO:0001656 58 31 3,000 1,631E-04 4,574E-03 ! positive regulation of gene-specific transcription GO:0043193 47 31 3,000 1,631E-04 4,519E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 3,000 1,851E-04 5,067E-03 ! meiosis I GO:0007127 52 32 3,000 1,851E-04 5,008E-03 ! regulation of protein stability GO:0031647 48 32 3,000 1,851E-04 4,949E-03 ! positive regulation of protein import into nucleus GO:0042307 23 13 2,000 1,902E-04 5,029E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 1,902E-04 4,972E-03 ! negative regulation of cell adhesion GO:0007162 67 33 3,000 2,091E-04 5,404E-03 ! ear morphogenesis GO:0042471 42 33 3,000 2,091E-04 5,344E-03 ! angiogenesis GO:0001525 149 95 5,000 2,145E-04 5,421E-03 ! urogenital system development GO:0001655 101 61 4,000 2,174E-04 5,434E-03 ! respiratory tube development GO:0030323 99 62 4,000 2,348E-04 5,806E-03 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 3,000 2,354E-04 5,759E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 2,354E-04 5,698E-03 ! embryonic organ development GO:0048568 45 34 3,000 2,354E-04 5,639E-03 ! regulation of S phase GO:0033261 18 14 2,000 2,405E-04 5,703E-03 ! heterophilic cell adhesion GO:0007157 29 14 2,000 2,405E-04 5,645E-03 ! inositol metabolic process GO:0006020 20 14 2,000 2,405E-04 5,588E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 2,405E-04 5,532E-03 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 2,000 2,405E-04 5,477E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 2,987E-04 6,735E-03 ! cardiac muscle tissue development GO:0048738 23 15 2,000 2,987E-04 6,669E-03 ! positive regulation of oxidoreductase activity GO:0051353 21 15 2,000 2,987E-04 6,605E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 2,987E-04 6,542E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! endothelial cell migration GO:0043542 22 16 2,000 3,652E-04 7,924E-03 ! nerve development GO:0021675 18 16 2,000 3,652E-04 7,85E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 4,031E-04 8,585E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 4,405E-04 9,295E-03 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 4,405E-04 9,211E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 4,000 4,427E-04 9,173E-03 ! JAK-STAT cascade GO:0007259 53 40 3,000 4,448E-04 9,134E-03 ! positive regulation of protein transport GO:0051222 55 40 3,000 4,448E-04 9,054E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 5,251E-04 0,01059503 ! response to retinoic acid GO:0032526 25 18 2,000 5,251E-04 0,0105029 ! negative regulation of neuron differentiation GO:0045665 24 18 2,000 5,251E-04 0,01041236 ! gut development GO:0048565 26 18 2,000 5,251E-04 0,01032336 ! negative regulation of T cell activation GO:0050868 25 18 2,000 5,251E-04 0,01023588 ! protein import into nucleus GO:0006606 118 74 4,000 5,36E-04 0,01036039 ! regulation of ligase activity GO:0051340 114 75 4,000 5,702E-04 0,01092908 ! nuclear import GO:0051170 121 75 4,000 5,702E-04 0,01083875 ! regulation of gene-specific transcription GO:0032583 69 43 3,000 5,882E-04 0,01108973 ! DNA-dependent DNA replication GO:0006261 59 43 3,000 5,882E-04 0,01099957 ! response to insulin stimulus GO:0032868 63 43 3,000 5,882E-04 0,01091086 ! epithelial tube morphogenesis GO:0060562 65 43 3,000 5,882E-04 0,01082358 ! reciprocal meiotic recombination GO:0007131 31 19 2,000 6,195E-04 0,01130859 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 6,195E-04 0,01121954 ! response to vitamin A GO:0033189 26 19 2,000 6,195E-04 0,01113189 ! negative regulation of angiogenesis GO:0016525 36 19 2,000 6,195E-04 0,0110456 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 6,195E-04 0,01096063 ! negative regulation of cell migration GO:0030336 92 44 3,000 6,426E-04 0,01128186 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 6,426E-04 0,01119639 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 7,004E-04 0,01211179 ! response to vitamin GO:0033273 29 20 2,000 7,241E-04 0,01242781 ! protein localization in nucleus GO:0034504 133 80 4,000 7,662E-04 0,01305395 ! negative regulation of bone resorption GO:0045779 10 5 1,000 7,873E-04 0,01331485 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 7,873E-04 0,01321766 ! forebrain regionalization GO:0021871 6 5 1,000 7,873E-04 0,01312188 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 7,873E-04 0,01302748 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 7,873E-04 0,01293443 ! embryonic hemopoiesis GO:0035162 10 5 1,000 7,873E-04 0,01284269 ! positive regulation of glycolysis GO:0045821 11 5 1,000 7,873E-04 0,01275225 ! microvillus organization GO:0032528 7 5 1,000 7,873E-04 0,01266308 GO:0030033|microvillus assembly, ! nerve growth factor processing GO:0032455 7 5 1,000 7,873E-04 0,01257514 ! positive regulation of neuroblast proliferation GO:0002052 8 5 1,000 7,873E-04 0,01248841 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 7,873E-04 0,01240288 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 7,873E-04 0,0123185 GO:0045686|negative regulation of glial cell differentiation, ! centrosome duplication GO:0051298 5 5 1,000 7,873E-04 0,01223527 ! response to UV-C GO:0010225 6 5 1,000 7,873E-04 0,01215315 ! positive regulation of chemokine production GO:0032722 7 5 1,000 7,873E-04 0,01207213 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 7,873E-04 0,01199218 GO:0007439|ectodermal gut development, ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 7,873E-04 0,01191329 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 8,269E-04 0,0124299 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cell aging GO:0007569 32 21 2,000 8,392E-04 0,01253331 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 2,000 8,392E-04 0,01245245 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 8,392E-04 0,01237263 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 2,000 8,392E-04 0,01229382 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 8,392E-04 0,01221601 ! regulation of DNA replication GO:0006275 75 48 3,000 8,958E-04 0,01295783 ! regulation of cell adhesion GO:0030155 159 83 4,000 9,057E-04 0,01301913 ! microtubule cytoskeleton organization GO:0000226 120 84 4,000 9,561E-04 0,01365878 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 9,653E-04 0,01370511 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 9,653E-04 0,01362102 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 9,653E-04 0,01353797 ! ureteric bud development GO:0001657 32 22 2,000 9,653E-04 0,01345592 ! ear development GO:0043583 72 50 3,000 1,046E-03 0,01448715 ! lipid modification GO:0030258 73 50 3,000 1,046E-03 0,0144004 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 1,103E-03 0,01509833 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,103E-03 0,01500899 ! cellular response to oxidative stress GO:0034599 33 23 2,000 1,103E-03 0,0149207 ! negative regulation of cell motion GO:0051271 104 51 3,000 1,127E-03 0,01515484 ! regulation of helicase activity GO:0051095 11 6 1,000 1,174E-03 0,01569888 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 1,174E-03 0,01560813 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,174E-03 0,01551843 ! signal peptide processing GO:0006465 8 6 1,000 1,174E-03 0,01542975 ! mRNA stabilization GO:0048255 15 6 1,000 1,174E-03 0,01534208 GO:0043489|RNA stabilization, ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 1,174E-03 0,0152554 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,174E-03 0,0151697 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,174E-03 0,01508495 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,174E-03 0,01500115 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 1,174E-03 0,01491827 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 1,174E-03 0,0148363 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 1,174E-03 0,01475523 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 1,174E-03 0,01467504 ! gas homeostasis GO:0033483 11 6 1,000 1,174E-03 0,01459571 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,174E-03 0,01451724 ! blastocyst growth GO:0001832 15 6 1,000 1,174E-03 0,01443961 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,174E-03 0,0143628 ! nucleotide-excision repair GO:0006289 64 52 3,000 1,212E-03 0,01475139 ! regulation of neurogenesis GO:0050767 153 89 4,000 1,24E-03 0,01501329 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 1,252E-03 0,0150779 ! negative regulation of cell development GO:0010721 56 24 2,000 1,252E-03 0,01499937 GO:0050768|negative regulation of neurogenesis, ! regulation of mitosis GO:0007088 84 54 3,000 1,397E-03 0,01664231 GO:0051783|regulation of nuclear division, ! positive regulation of nuclear division GO:0051785 39 25 2,000 1,414E-03 0,0167585 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,414E-03 0,01667255 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 1,587E-03 0,01862828 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 1,6E-03 0,01867488 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,634E-03 0,01897982 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,634E-03 0,01888445 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 1,000 1,634E-03 0,01879002 ! microtubule bundle formation GO:0001578 8 7 1,000 1,634E-03 0,01869654 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,634E-03 0,01860398 ! spinal cord patterning GO:0021511 7 7 1,000 1,634E-03 0,01851234 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,634E-03 0,01842159 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,634E-03 0,01833173 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,634E-03 0,01824274 ! B cell lineage commitment GO:0002326 17 7 1,000 1,634E-03 0,01815461 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 1,634E-03 0,01806733 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,634E-03 0,01798088 ! T cell lineage commitment GO:0002360 12 7 1,000 1,634E-03 0,01789526 ! response to tumor cell GO:0002347 12 7 1,000 1,634E-03 0,01781045 ! neuroblast proliferation GO:0007405 13 7 1,000 1,634E-03 0,01772644 ! embryonic heart tube development GO:0035050 7 7 1,000 1,634E-03 0,01764321 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 1,708E-03 0,01836109 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 1,708E-03 0,01827569 ! response to light stimulus GO:0009416 153 96 4,000 1,737E-03 0,01849631 ! inner ear morphogenesis GO:0042472 35 27 2,000 1,774E-03 0,01880482 ! response to ionizing radiation GO:0010212 47 27 2,000 1,774E-03 0,01871856 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,774E-03 0,01863309 ! negative regulation of protein transport GO:0051224 49 27 2,000 1,774E-03 0,01854839 ! negative regulation of kinase activity GO:0033673 100 58 3,000 1,822E-03 0,01896463 ! lung development GO:0030324 94 59 3,000 1,941E-03 0,0201124 ! cell junction assembly GO:0034329 56 28 2,000 1,974E-03 0,02036062 ! positive regulation of catabolic process GO:0009896 40 28 2,000 1,974E-03 0,02026972 ! regulation of B cell activation GO:0050864 42 28 2,000 1,974E-03 0,02017964 ! protein import GO:0017038 156 99 4,000 1,989E-03 0,02024613 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 2,066E-03 0,02092887 ! protein localization in organelle GO:0033365 161 100 4,000 2,079E-03 0,02097421 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,166E-03 0,02175177 ! induction of positive chemotaxis GO:0050930 14 8 1,000 2,166E-03 0,0216572 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,166E-03 0,02156345 ! smoothened signaling pathway GO:0007224 8 8 1,000 2,166E-03 0,0214705 ! middle ear morphogenesis GO:0042474 9 8 1,000 2,166E-03 0,02137835 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 2,166E-03 0,02128699 ! multicellular organism growth GO:0035264 14 8 1,000 2,166E-03 0,02119641 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,166E-03 0,02110659 ! regulation of gliogenesis GO:0014013 20 8 1,000 2,166E-03 0,02101754 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 2,166E-03 0,02092923 ! induction of an organ GO:0001759 11 8 1,000 2,166E-03 0,02084166 ! S phase GO:0051320 8 8 1,000 2,166E-03 0,02075482 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 14 8 1,000 2,166E-03 0,0206687 ! telencephalon development GO:0021537 52 29 2,000 2,187E-03 0,02079003 ! cell-matrix adhesion GO:0007160 114 61 3,000 2,195E-03 0,02077844 ! negative regulation of transferase activity GO:0051348 105 61 3,000 2,195E-03 0,02069329 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 3,000 2,33E-03 0,02187814 ! spindle organization GO:0007051 37 30 2,000 2,415E-03 0,02257585 ! negative regulation of cell activation GO:0050866 44 30 2,000 2,415E-03 0,02248445 ! cell cycle checkpoint GO:0000075 108 64 3,000 2,618E-03 0,02427904 ! appendage morphogenesis GO:0035107 93 64 3,000 2,618E-03 0,02418153 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 3,000 2,618E-03 0,0240848 ! cell fate specification GO:0001708 37 31 2,000 2,656E-03 0,0243367 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,768E-03 0,02526446 ! regulation of glycolysis GO:0006110 15 9 1,000 2,768E-03 0,0251646 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 2,768E-03 0,02506553 ! lung alveolus development GO:0048286 17 9 1,000 2,768E-03 0,02496723 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 2,768E-03 0,0248697 ! regulation of exit from mitosis GO:0007096 12 9 1,000 2,768E-03 0,02477293 ! ventral spinal cord development GO:0021517 11 9 1,000 2,768E-03 0,02467692 ! telomere maintenance via telomerase GO:0007004 12 9 1,000 2,768E-03 0,02458164 GO:0010833|telomere maintenance via telomere lengthening, ! motor axon guidance GO:0008045 14 9 1,000 2,768E-03 0,02448709 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 2,768E-03 0,02439327 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 2,768E-03 0,02430017 ! oocyte differentiation GO:0009994 12 9 1,000 2,768E-03 0,02420777 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 2,768E-03 0,02411608 ! embryonic placenta development GO:0001892 12 9 1,000 2,768E-03 0,02402507 ! localization within membrane GO:0051668 15 9 1,000 2,768E-03 0,02393475 ! regulation of caspase activity GO:0043281 97 65 3,000 2,77E-03 0,02386445 ! appendage development GO:0048736 94 65 3,000 2,77E-03 0,0237754 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 3,000 2,77E-03 0,02368701 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 3,000 2,77E-03 0,02359929 ! protein oligomerization GO:0051259 100 65 3,000 2,77E-03 0,0235122 ! cell-substrate adhesion GO:0031589 121 66 3,000 2,929E-03 0,02476525 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 3,093E-03 0,02606039 ! regulation of neuron differentiation GO:0045664 107 67 3,000 3,093E-03 0,02596528 ! cell junction organization GO:0034330 63 33 2,000 3,182E-03 0,02661068 ! nucleus organization GO:0006997 49 33 2,000 3,182E-03 0,02651427 ! negative regulation of DNA binding GO:0043392 54 33 2,000 3,182E-03 0,02641855 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 3,182E-03 0,02632352 ! cytokinesis GO:0000910 52 33 2,000 3,182E-03 0,02622917 ! negative regulation of muscle development GO:0048635 12 10 1,000 3,44E-03 0,02825533 ! neuron fate specification GO:0048665 11 10 1,000 3,44E-03 0,02815477 ! hippocampus development GO:0021766 19 10 1,000 3,44E-03 0,02805493 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 3,44E-03 0,0279558 ! blood vessel remodeling GO:0001974 21 10 1,000 3,44E-03 0,02785736 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 3,44E-03 0,02775962 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 3,44E-03 0,02766256 ! entry into host cell GO:0030260 20 10 1,000 3,44E-03 0,02756617 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 3,44E-03 0,02747046 ! regulation of bone resorption GO:0045124 24 10 1,000 3,44E-03 0,0273754 ! RNA-dependent DNA replication GO:0006278 13 10 1,000 3,44E-03 0,027281 ! DNA methylation GO:0006306 15 10 1,000 3,44E-03 0,02718726 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 1,000 3,44E-03 0,02709415 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 3,44E-03 0,02700168 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 3,44E-03 0,02690983 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 3,44E-03 0,02681861 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 3,44E-03 0,02672801 ! positive regulation of ligase activity GO:0051351 99 69 3,000 3,441E-03 0,02664709 ! polyol metabolic process GO:0019751 44 34 2,000 3,467E-03 0,02675751 ! protein homooligomerization GO:0051260 52 35 2,000 3,767E-03 0,02897785 ! regulation of peptidase activity GO:0052547 106 72 3,000 4,011E-03 0,03075031 ! response to hypoxia GO:0001666 132 72 3,000 4,011E-03 0,03064815 ! negative regulation of binding GO:0051100 58 36 2,000 4,083E-03 0,03109407 ! tissue remodeling GO:0048771 62 36 2,000 4,083E-03 0,03099145 ! neural tube development GO:0021915 50 36 2,000 4,083E-03 0,0308895 ! RNA polyadenylation GO:0043631 19 11 1,000 4,179E-03 0,03151725 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 4,179E-03 0,03141425 GO:0050927|positive regulation of positive chemotaxis, ! regulation of mRNA processing GO:0050684 18 11 1,000 4,179E-03 0,03131192 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 4,179E-03 0,03121026 ! focal adhesion formation GO:0048041 24 11 1,000 4,179E-03 0,03110926 ! regulation of intracellular pH GO:0051453 17 11 1,000 4,179E-03 0,0310089 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 4,179E-03 0,0309092 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 1,000 4,179E-03 0,03081013 ! regulation of leukocyte migration GO:0002685 24 11 1,000 4,179E-03 0,03071169 ! digestive tract morphogenesis GO:0048546 15 11 1,000 4,179E-03 0,03061389 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! mRNA 3'-end processing GO:0031124 19 11 1,000 4,179E-03 0,0305167 ! tube morphogenesis GO:0035239 118 73 3,000 4,214E-03 0,03067329 ! response to oxygen levels GO:0070482 137 74 3,000 4,424E-03 0,03210151 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 4,424E-03 0,03200057 ! response to nutrient GO:0007584 104 75 3,000 4,642E-03 0,03346583 ! regulation of T cell proliferation GO:0042129 58 38 2,000 4,761E-03 0,03422107 ! response to unfolded protein GO:0006986 99 76 3,000 4,866E-03 0,03486372 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 4,986E-03 0,03561352 ! non-recombinational repair GO:0000726 19 12 1,000 4,986E-03 0,03550326 GO:0006303|double-strand break repair via nonhomologous end joining, ! cartilage condensation GO:0001502 18 12 1,000 4,986E-03 0,03539368 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 4,986E-03 0,03528478 ! cytokine biosynthetic process GO:0042089 16 12 1,000 4,986E-03 0,03517655 ! heart looping GO:0001947 15 12 1,000 4,986E-03 0,03506897 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 4,986E-03 0,03496205 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 4,986E-03 0,03485579 ! autonomic nervous system development GO:0048483 23 12 1,000 4,986E-03 0,03475016 ! peptidyl-lysine modification GO:0018205 18 12 1,000 4,986E-03 0,03464518 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 4,986E-03 0,03454082 ! RNA 3'-end processing GO:0031123 20 12 1,000 4,986E-03 0,0344371 ! regulation of DNA binding GO:0051101 119 77 3,000 5,097E-03 0,03509995 ! developmental growth GO:0048589 62 39 2,000 5,124E-03 0,03518221 ! synapse organization GO:0050808 55 39 2,000 5,124E-03 0,0350775 ! inner ear development GO:0048839 57 40 2,000 5,504E-03 0,03756295 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 5,504E-03 0,03745182 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 5,858E-03 0,0397434 ! regulation of chemokine production GO:0032642 17 13 1,000 5,858E-03 0,03962651 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 5,858E-03 0,0395103 ! cytokine metabolic process GO:0042107 17 13 1,000 5,858E-03 0,03939477 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 5,858E-03 0,03927992 ! regulation of cellular pH GO:0030641 20 13 1,000 5,858E-03 0,03916573 ! regulation of T cell differentiation GO:0045580 59 41 2,000 5,9E-03 0,03933104 ! response to protein stimulus GO:0051789 111 81 3,000 6,096E-03 0,0405238 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 6,312E-03 0,04183846 ! activation of caspase activity GO:0006919 65 43 2,000 6,741E-03 0,04455551 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 6,794E-03 0,04477454 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 6,794E-03 0,04464662 ! limbic system development GO:0021761 25 14 1,000 6,794E-03 0,04451942 ! cellular response to starvation GO:0009267 21 14 1,000 6,794E-03 0,04439294 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 6,794E-03 0,04426718 GO:0031114|regulation of microtubule depolymerization, ! embryo implantation GO:0007566 27 14 1,000 6,794E-03 0,04414213 ! G1/S transition checkpoint GO:0031575 33 14 1,000 6,794E-03 0,04401779 ! DNA unwinding during replication GO:0006268 21 14 1,000 6,794E-03 0,04389414 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 6,794E-03 0,04377119 ! muscle maintenance GO:0046716 19 14 1,000 6,794E-03 0,04364893 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 6,794E-03 0,04352734 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 6,794E-03 0,04340643 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 7,218E-03 0,04598546 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 7,793E-03 0,04951569 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 7,793E-03 0,04937928 ! lipid phosphorylation GO:0046834 23 15 1,000 7,793E-03 0,04924363 ! centrosome cycle GO:0007098 16 15 1,000 7,793E-03 0,04910871 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 7,793E-03 0,04897454 ! neuron recognition GO:0008038 22 15 1,000 7,793E-03 0,04884109 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 7,793E-03 0,04870837 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 7,793E-03 0,04857637 ! peptide biosynthetic process GO:0043043 19 15 1,000 7,793E-03 0,04844508 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 7,793E-03 0,0483145 ! peptide hormone processing GO:0016486 19 15 1,000 7,793E-03 0,04818462 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 7,793E-03 0,04805544 ! skeletal muscle tissue development GO:0007519 123 87 3,000 7,826E-03 0,04812948 GO:0060538|skeletal muscle organ development, ! anatomical structure homeostasis GO:0060249 136 88 3,000 8,143E-03 0,04994257 ! viral infectious cycle GO:0019058 71 47 2,000 8,63E-03 0,05278862 ! endocrine system development GO:0035270 83 47 2,000 8,63E-03 0,05264859 ! negative regulation of immune system process GO:0002683 73 47 2,000 8,63E-03 0,05250931 ! protein secretion GO:0009306 27 16 1,000 8,855E-03 0,05373446 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 8,855E-03 0,05359306 ! protein amino acid acetylation GO:0006473 28 16 1,000 8,855E-03 0,05345239 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 8,855E-03 0,05331247 ! oogenesis GO:0048477 23 16 1,000 8,855E-03 0,05317327 ! neural crest cell migration GO:0001755 24 16 1,000 8,855E-03 0,0530348 ! G1 phase GO:0051318 27 16 1,000 8,855E-03 0,05289704 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 8,855E-03 0,05276 ! positive regulation of caspase activity GO:0043280 72 48 2,000 9,145E-03 0,05435246 GO:0010952|positive regulation of peptidase activity, ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 9,145E-03 0,05421238 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 9,493E-03 0,05612648 ! cell fate commitment GO:0045165 141 92 3,000 9,493E-03 0,05598257 ! DNA recombination GO:0006310 146 92 3,000 9,493E-03 0,05583939 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 9,679E-03 0,05678804 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 9,679E-03 0,05664354 ! cartilage development GO:0051216 70 49 2,000 9,679E-03 0,05649978 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 9,852E-03 0,05736325 ! forelimb morphogenesis GO:0035136 19 17 1,000 9,976E-03 0,05794357 ! memory GO:0007613 25 17 1,000 9,976E-03 0,05779761 ! DNA duplex unwinding GO:0032508 25 17 1,000 9,976E-03 0,05765239 GO:0032392|DNA geometric change, ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 9,976E-03 0,0575079 ! actin filament bundle formation GO:0051017 26 17 1,000 9,976E-03 0,05736413 ! neuromuscular junction development GO:0007528 23 17 1,000 9,976E-03 0,05722108 ! synaptogenesis GO:0007416 24 17 1,000 9,976E-03 0,05707874 ! peptidyl-serine modification GO:0018209 27 17 1,000 9,976E-03 0,0569371 ! proximal/distal pattern formation GO:0009954 25 17 1,000 9,976E-03 0,05679617 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 9,976E-03 0,05665593 ! skeletal muscle fiber development GO:0048741 73 50 2,000 0,0102297 0,05795153 ! regulation of binding GO:0051098 151 95 3,000 0,01059532 0,05987528 ! muscle fiber development GO:0048747 74 51 2,000 0,01079864 0,06087469 ! positive regulation of organelle organization GO:0010638 82 51 2,000 0,01079864 0,06072585 ! in utero embryonic development GO:0001701 147 96 3,000 0,01098046 0,06159772 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 0,01115777 0,0624401 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 0,01115777 0,06228854 ! axis specification GO:0009798 26 18 1,000 0,01115777 0,06213772 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 0,01115777 0,06198763 GO:0050886|endocrine process, ! central nervous system neuron development GO:0021954 30 18 1,000 0,01115777 0,06183826 ! somitogenesis GO:0001756 24 18 1,000 0,01115777 0,06168961 ! cellular response to nutrient levels GO:0031669 27 18 1,000 0,01115777 0,06154168 ! activation of JUN kinase activity GO:0007257 23 18 1,000 0,01115777 0,06139445 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 0,01115777 0,06124792 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 0,01115777 0,06110209 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01239757 0,06773019 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,01239757 0,06756969 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,01239757 0,06740995 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 0,01239757 0,06725096 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01239757 0,06709273 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 0,01239757 0,06693523 ! apoptotic nuclear changes GO:0030262 24 19 1,000 0,01239757 0,06677847 ! response to starvation GO:0042594 30 19 1,000 0,01239757 0,06662245 ! plasma membrane fusion GO:0045026 23 19 1,000 0,01239757 0,06646715 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,01239757 0,06631258 ! renal system process GO:0003014 35 19 1,000 0,01239757 0,06615872 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 0,01239757 0,06600558 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 0,01239757 0,06585314 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01369463 0,07257521 ! spinal cord development GO:0021510 31 20 1,000 0,01369463 0,07240837 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01369463 0,07224229 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 0,01369463 0,07207698 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 0,01369463 0,07191242 ! pallium development GO:0021543 38 20 1,000 0,01369463 0,07174861 ! DNA modification GO:0006304 28 20 1,000 0,01369463 0,07158555 ! positive regulation of locomotion GO:0040017 35 20 1,000 0,01369463 0,07142322 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01369463 0,07126163 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 0,01369463 0,07110077 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01504783 0,07795047 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 0,01504783 0,0777753 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01504783 0,07760092 ! regulation of chemotaxis GO:0050920 36 21 1,000 0,01504783 0,07742731 ! dendrite development GO:0016358 35 21 1,000 0,01504783 0,07725448 ! regulation of DNA recombination GO:0000018 40 21 1,000 0,01504783 0,07708243 ! viral reproductive process GO:0022415 87 58 2,000 0,01528967 0,07814722 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 0,01528967 0,07797395 ! leukocyte adhesion GO:0007159 38 22 1,000 0,01645608 0,0837367 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01645608 0,08355185 ! vasculogenesis GO:0001570 33 22 1,000 0,01645608 0,08336781 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01645608 0,08318459 GO:0051297|centrosome organization, ! regulation of behavior GO:0050795 38 22 1,000 0,01645608 0,08300217 ! blastocyst development GO:0001824 37 22 1,000 0,01645608 0,08282054 ! neural tube closure GO:0001843 33 22 1,000 0,01645608 0,08263971 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 0,01645608 0,08245967 ! protein tetramerization GO:0051262 39 22 1,000 0,01645608 0,08228041 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 0,01673841 0,08351049 GO:0035113|embryonic appendage morphogenesis, ! regulation of homeostatic process GO:0032844 105 60 2,000 0,01673841 0,08332974 ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,01749064 0,08688654 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 0,01749064 0,08669928 ! neuron fate commitment GO:0048663 32 23 1,000 0,0179183 0,08862813 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,0179183 0,08843794 ! myelination GO:0042552 35 23 1,000 0,0179183 0,08824856 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,0179183 0,08806 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,0179183 0,08787224 ! interaction with host GO:0051701 37 23 1,000 0,0179183 0,08768528 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 0,0179183 0,08749911 ! telomere organization GO:0032200 32 23 1,000 0,0179183 0,08731373 GO:0000723|telomere maintenance, ! liver development GO:0001889 40 23 1,000 0,0179183 0,08712913 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,019051 0,09244156 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,019051 0,09224695 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,019051 0,09205315 ! viral reproduction GO:0016032 92 63 2,000 0,019051 0,09186017 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,0194334 0,093508 ! initiation of viral infection GO:0019059 42 24 1,000 0,0194334 0,09331279 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,0194334 0,09311839 ! neural crest cell development GO:0014032 39 24 1,000 0,0194334 0,09292479 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 0,0194334 0,092732 ! primary neural tube formation GO:0014020 35 24 1,000 0,0194334 0,09254001 ! base-excision repair GO:0006284 31 24 1,000 0,0194334 0,09234881 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,0194334 0,0921584 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,0194334 0,09196878 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,02100035 0,09918028 ! iron ion homeostasis GO:0055072 39 25 1,000 0,02100035 0,09897704 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,02100035 0,09877464 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,02100035 0,09857306 ! axon guidance GO:0007411 99 66 2,000 0,02153165 0,10086109 ! regulation of pH GO:0006885 36 26 1,000 0,02261809 0,10573496 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,02261809 0,10552049 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,02261809 0,10530689 ! response to drug GO:0042493 108 69 2,000 0,02418069 0,11235474 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,0242856 0,11261467 GO:0043433|negative regulation of transcription factor activity, ! regulation of catabolic process GO:0009894 106 70 2,000 0,02510113 0,11616215 ! mRNA export from nucleus GO:0006406 39 28 1,000 0,02600187 0,12008895 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02600187 0,11984829 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02600187 0,1196086 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,02600187 0,11936986 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02600187 0,11913207 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,02600187 0,11889523 ! placenta development GO:0001890 37 28 1,000 0,02600187 0,11865932 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,02604025 0,11859916 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,02699805 0,12271839 ! mismatch repair GO:0006298 34 29 1,000 0,0277659 0,1259597 ! eye morphogenesis GO:0048592 51 29 1,000 0,0277659 0,12571174 ! tissue homeostasis GO:0001894 42 29 1,000 0,0277659 0,12546477 GO:0048871|multicellular organismal homeostasis, ! negative regulation of transport GO:0051051 116 73 2,000 0,0279745 0,12615949 ! mitochondrion organization GO:0007005 104 73 2,000 0,0279745 0,1259126 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,0295767 0,13286409 ! hindbrain development GO:0030902 45 30 1,000 0,0295767 0,1326051 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,0295767 0,13234711 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,0295767 0,13209013 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,03143331 0,14010972 ! glial cell differentiation GO:0010001 55 31 1,000 0,03143331 0,13983872 ! odontogenesis GO:0042476 50 31 1,000 0,03143331 0,13956876 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,03143331 0,13929984 ! segmentation GO:0035282 41 31 1,000 0,03143331 0,13903195 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,03143331 0,1387651 ! protein ubiquitination GO:0016567 125 77 2,000 0,0320662 0,14128787 ! regulation of muscle development GO:0048634 48 32 1,000 0,03333477 0,14659649 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,03333477 0,14631673 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,03333477 0,14603803 ! peripheral nervous system development GO:0007422 53 32 1,000 0,03333477 0,14576039 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,03333477 0,1454838 ! cytokine production GO:0001816 44 32 1,000 0,03333477 0,14520827 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,03333477 0,14493377 ! RNA export from nucleus GO:0006405 44 33 1,000 0,03528013 0,15310243 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,03528013 0,1528141 ! sister chromatid segregation GO:0000819 46 33 1,000 0,03528013 0,15252686 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,03528013 0,15224069 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 0,03528013 0,1519556 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03528013 0,15167157 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,03528013 0,1513886 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,03532909 0,1513164 GO:0010498|proteasomal protein catabolic process, ! mRNA transport GO:0051028 121 81 2,000 0,03645343 0,15584181 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,03726846 0,15903052 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,03726846 0,15873601 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,03726846 0,1584426 ! neuron migration GO:0001764 46 34 1,000 0,03726846 0,15815027 ! female gamete generation GO:0007292 43 34 1,000 0,03726846 0,15785902 ! ossification GO:0001503 134 82 2,000 0,03759604 0,15895383 GO:0060348|bone development, ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,03929884 0,16584831 ! maintenance of protein location GO:0045185 65 35 1,000 0,03929884 0,16554456 ! glycogen metabolic process GO:0005977 48 35 1,000 0,03929884 0,16524192 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,03929884 0,16494039 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04137037 0,1733185 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,04137037 0,17300337 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04137037 0,17268939 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,04137037 0,17237655 GO:0006073|cellular glucan metabolic process, ! amino acid activation GO:0043038 52 37 1,000 0,04348216 0,18084805 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,04358068 0,18093064 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04410897 0,18279394 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04410897 0,18246517 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04410897 0,18213759 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04410897 0,18181118 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04410897 0,18148593 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04410897 0,18116185 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04410897 0,18083892 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04410897 0,18051715 ! sleep GO:0030431 11 5 0,000 0,04410897 0,18019651 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04410897 0,17987701 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04410897 0,17955865 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04410897 0,17924141 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 6 5 0,000 0,04410897 0,17892528 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04410897 0,17861027 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04410897 0,17829637 ! cobalt ion transport GO:0006824 9 5 0,000 0,04410897 0,17798357 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04410897 0,17767187 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04410897 0,17736125 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04410897 0,17705172 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04410897 0,17674327 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04410897 0,17643589 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04410897 0,17612958 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04410897 0,17582433 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04410897 0,17552013 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04410897 0,17521699 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04410897 0,17491489 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04410897 0,17461383 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04410897 0,17431381 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04410897 0,17401481 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04410897 0,17371684 ! malate metabolic process GO:0006108 7 5 0,000 0,04410897 0,17341989 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04410897 0,17312395 ! behavioral response to pain GO:0048266 7 5 0,000 0,04410897 0,17282902 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04410897 0,17253509 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04410897 0,17224217 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04410897 0,17195023 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04410897 0,17165928 ! mating behavior GO:0007617 6 5 0,000 0,04410897 0,17136932 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04410897 0,17108033 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04410897 0,17079232 ! rhythmic behavior GO:0007622 12 5 0,000 0,04410897 0,17050527 ! copulation GO:0007620 7 5 0,000 0,04410897 0,17021919 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04410897 0,16993406 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04410897 0,16964989 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04410897 0,16936667 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04410897 0,16908439 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04410897 0,16880305 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04410897 0,16852265 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04410897 0,16824318 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04410897 0,16796463 ! response to protozoan GO:0001562 9 5 0,000 0,04410897 0,167687 ! lymph vessel development GO:0001945 7 5 0,000 0,04410897 0,16741029 ! endochondral ossification GO:0001958 12 5 0,000 0,04410897 0,16713449 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04410897 0,1668596 ! parathyroid gland development GO:0060017 8 5 0,000 0,04410897 0,16658561 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04410897 0,16631252 ! anagen GO:0042640 6 5 0,000 0,04410897 0,16604032 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04410897 0,16576901 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04410897 0,16549859 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04410897 0,16522905 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04410897 0,16496038 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04410897 0,16469259 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04410897 0,16442567 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04410897 0,1641596 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04410897 0,1638944 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04410897 0,16363006 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,04410897 0,16336656 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04410897 0,16310392 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04410897 0,16284211 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,04410897 0,16258115 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04410897 0,16232102 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04410897 0,16206172 ! ovulation GO:0030728 6 5 0,000 0,04410897 0,16180325 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04410897 0,1615456 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,04410897 0,16128877 ! response to pH GO:0009268 9 5 0,000 0,04410897 0,16103276 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04410897 0,16077755 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04410897 0,16052316 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04410897 0,16026957 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04410897 0,16001678 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04410897 0,15976478 ! polyol catabolic process GO:0046174 7 5 0,000 0,04410897 0,15951358 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04410897 0,15926316 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04410897 0,15901354 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04410897 0,15876469 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04410897 0,15851662 ! urea metabolic process GO:0019627 6 5 0,000 0,04410897 0,15826932 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04410897 0,1580228 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04410897 0,15777704 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04410897 0,15753204 ! neutrophil activation GO:0042119 5 5 0,000 0,04410897 0,15728781 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04410897 0,15704433 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04410897 0,1568016 ! response to food GO:0032094 5 5 0,000 0,04410897 0,15655962 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04410897 0,15631839 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04410897 0,1560779 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04410897 0,15583815 ! forebrain neuron development GO:0021884 7 5 0,000 0,04410897 0,15559913 ! melanosome organization GO:0032438 7 5 0,000 0,04410897 0,15536085 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04410897 0,1551233 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04410897 0,15488647 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04410897 0,15465036 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,04410897 0,15441497 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04410897 0,1541803 ! nucleoside transport GO:0015858 6 5 0,000 0,04410897 0,15394634 ! nucleoside salvage GO:0043174 7 5 0,000 0,04410897 0,15371308 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04410897 0,15348054 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04410897 0,15324869 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04410897 0,15301755 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04410897 0,1527871 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04410897 0,15255735 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04410897 0,15232828 ! depyrimidination GO:0045008 8 5 0,000 0,04410897 0,1520999 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04410897 0,15187221 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04410897 0,1516452 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04410897 0,15141886 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04410897 0,1511932 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04410897 0,15096821 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04410897 0,15074389 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,04410897 0,15052023 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04410897 0,15029724 ! monocyte differentiation GO:0030224 8 5 0,000 0,04410897 0,1500749 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04410897 0,14985323 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04410897 0,14963221 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04410897 0,14941183 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04410897 0,14919211 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04410897 0,14897303 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04410897 0,1487546 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04410897 0,1485368 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04410897 0,14831964 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04410897 0,14810312 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04410897 0,14788722 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04410897 0,14767196 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04410897 0,14745732 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04410897 0,1472433 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04410897 0,14702991 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04410897 0,14681713 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04410897 0,14660496 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04410897 0,14639341 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04410897 0,14618247 ! neural tube patterning GO:0021532 6 5 0,000 0,04410897 0,14597214 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04410897 0,14576241 ! histone demethylation GO:0016577 9 5 0,000 0,04410897 0,14555328 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04410897 0,14534475 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04410897 0,14513682 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,04410897 0,14492948 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04410897 0,14472273 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04410897 0,14451658 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04410897 0,144311 ! transcription termination GO:0006353 8 5 0,000 0,04410897 0,14410602 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04410897 0,14390161 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04410897 0,14369778 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04410897 0,14349453 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,04410897 0,14329186 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04410897 0,14308975 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04410897 0,14288822 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04410897 0,14268725 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04410897 0,14248685 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04410897 0,14228701 ! apical protein localization GO:0045176 6 5 0,000 0,04410897 0,14208773 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04410897 0,141889 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04410897 0,14169083 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04410897 0,14149322 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04410897 0,14129615 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04410897 0,14109963 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04410897 0,14090366 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04410897 0,14070823 ! glial cell migration GO:0008347 10 5 0,000 0,04410897 0,14051335 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04410897 0,140319 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,04410897 0,14012519 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04410897 0,13993191 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04410897 0,13973917 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04410897 0,13954695 ! neural plate development GO:0001840 6 5 0,000 0,04410897 0,13935527 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04410897 0,13916411 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04410897 0,13897347 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04410897 0,13878336 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,04410897 0,13859376 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04410897 0,13840469 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04410897 0,13821613 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04410897 0,13802808 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04410897 0,13784054 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04410897 0,13765351 ! spindle assembly GO:0051225 5 5 0,000 0,04410897 0,13746699 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04410897 0,13728097 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04410897 0,13709545 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04410897 0,13691044 ! organ regeneration GO:0031100 7 5 0,000 0,04410897 0,13672592 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04410897 0,13654191 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04410897 0,13635838 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04410897 0,13617535 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04410897 0,13599281 GO:0055081|anion homeostasis, ! establishment of RNA localization GO:0051236 128 88 2,000 0,04483143 0,1380352 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! gliogenesis GO:0042063 71 38 1,000 0,04563333 0,14031638 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,04563333 0,14012904 ! mesenchymal cell development GO:0014031 64 38 1,000 0,04563333 0,1399422 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,04563333 0,13975586 ! regulation of T cell activation GO:0050863 128 89 2,000 0,04609994 0,14099715 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,04738611 0,14473846 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,047823 0,14587918 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,047823 0,14568596 ! JNK cascade GO:0007254 54 39 1,000 0,047823 0,14549325 ! RNA localization GO:0006403 135 91 2,000 0,04868987 0,14793488 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,05005033 0,15186774 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,05005033 0,15166765 ! peptide metabolic process GO:0006518 56 40 1,000 0,05005033 0,15146809 ! T cell differentiation GO:0030217 65 40 1,000 0,05005033 0,15126905 ! B cell differentiation GO:0030183 62 40 1,000 0,05005033 0,15107054 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,05231446 0,15769759 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,05231446 0,15749118 ! glucose transport GO:0015758 52 41 1,000 0,05231446 0,15728531 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,05231446 0,15707998 ! biopolymer methylation GO:0043414 62 41 1,000 0,05231446 0,15687518 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,05231446 0,15667092 ! tRNA transcription GO:0009304 11 6 0,000 0,05269597 0,15760822 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05269597 0,15740353 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,05269597 0,15719938 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05269597 0,15699575 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05269597 0,15679265 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05269597 0,15659008 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05269597 0,15638803 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05269597 0,1561865 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05269597 0,15598548 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05269597 0,15578499 ! prostate gland development GO:0030850 9 6 0,000 0,05269597 0,15558501 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05269597 0,15538554 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05269597 0,15518658 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05269597 0,15498814 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05269597 0,15479019 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05269597 0,15459276 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05269597 0,15439582 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05269597 0,15419939 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05269597 0,15400346 ! neuron adhesion GO:0007158 9 6 0,000 0,05269597 0,15380802 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05269597 0,15361308 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05269597 0,15341863 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05269597 0,15322468 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05269597 0,15303121 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05269597 0,15283824 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05269597 0,15264575 ! opsonization GO:0008228 8 6 0,000 0,05269597 0,15245374 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05269597 0,15226221 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05269597 0,15207117 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05269597 0,1518806 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05269597 0,15169052 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05269597 0,1515009 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05269597 0,15131176 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05269597 0,15112309 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05269597 0,1509349 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05269597 0,15074717 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05269597 0,1505599 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05269597 0,1503731 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05269597 0,15018677 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05269597 0,15000089 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05269597 0,14981548 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05269597 0,14963052 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05269597 0,14944602 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05269597 0,14926197 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05269597 0,14907838 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05269597 0,14889524 ! thymic T cell selection GO:0045061 12 6 0,000 0,05269597 0,14871254 ! protein lipoylation GO:0009249 10 6 0,000 0,05269597 0,1485303 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05269597 0,1483485 ! pigment granule organization GO:0048753 11 6 0,000 0,05269597 0,14816714 ! drug transport GO:0015893 6 6 0,000 0,05269597 0,14798623 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05269597 0,14780576 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05269597 0,14762573 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05269597 0,14744613 ! histidine metabolic process GO:0006547 6 6 0,000 0,05269597 0,14726698 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05269597 0,14708825 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05269597 0,14690997 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05269597 0,14673211 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05269597 0,14655468 ! adenohypophysis development GO:0021984 10 6 0,000 0,05269597 0,14637768 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05269597 0,14620111 ! hyperosmotic response GO:0006972 8 6 0,000 0,05269597 0,14602497 ! microtubule nucleation GO:0007020 10 6 0,000 0,05269597 0,14584924 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05269597 0,14567394 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05269597 0,14549907 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05269597 0,14532461 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05269597 0,14515056 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05269597 0,14497694 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,05269597 0,14480373 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05269597 0,14463093 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05269597 0,14445855 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05269597 0,14428657 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05269597 0,14411501 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,05269597 0,14394385 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05269597 0,1437731 ! neuron apoptosis GO:0051402 8 6 0,000 0,05269597 0,14360275 ! organic alcohol transport GO:0015850 9 6 0,000 0,05269597 0,14343281 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05269597 0,14326326 ! male sex determination GO:0030238 9 6 0,000 0,05269597 0,14309412 ! carnitine transport GO:0015879 8 6 0,000 0,05269597 0,14292538 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05269597 0,14275703 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05269597 0,14258908 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05269597 0,14242153 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05269597 0,14225437 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05269597 0,1420876 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05269597 0,14192122 ! parturition GO:0007567 12 6 0,000 0,05269597 0,14175523 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05269597 0,14158963 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05269597 0,14142441 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05269597 0,14125958 ! spindle checkpoint GO:0031577 14 6 0,000 0,05269597 0,14109514 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05269597 0,14093107 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05269597 0,14076739 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05269597 0,14060409 ! macrophage differentiation GO:0030225 10 6 0,000 0,05269597 0,14044116 ! astrocyte development GO:0014002 14 6 0,000 0,05269597 0,14027861 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05269597 0,14011644 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05269597 0,13995464 ! interaction with symbiont GO:0051702 8 6 0,000 0,05269597 0,13979322 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05269597 0,13963217 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05269597 0,13947149 ! eating behavior GO:0042755 6 6 0,000 0,05269597 0,13931117 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05269597 0,13915123 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05269597 0,13899165 ! response to copper ion GO:0046688 9 6 0,000 0,05269597 0,13883244 ! DNA topological change GO:0006265 8 6 0,000 0,05269597 0,13867359 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05269597 0,13851511 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05269597 0,13835699 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05269597 0,13819923 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05269597 0,13804182 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05269597 0,13788478 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05269597 0,13772809 ! hair follicle maturation GO:0048820 7 6 0,000 0,05269597 0,13757176 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05269597 0,13741578 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05269597 0,13726016 ! Schwann cell development GO:0014044 14 6 0,000 0,05269597 0,13710489 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05269597 0,13694997 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05269597 0,1367954 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05269597 0,13664117 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05269597 0,1364873 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,05269597 0,13633377 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05269597 0,13618059 ! histone ubiquitination GO:0016574 7 6 0,000 0,05269597 0,13602775 ! regulation of meiosis GO:0040020 10 6 0,000 0,05269597 0,13587525 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05269597 0,13572309 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05269597 0,13557128 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05269597 0,1354198 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05269597 0,13526866 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05269597 0,13511786 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05269597 0,1349674 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05269597 0,13481727 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05269597 0,13466747 ! receptor internalization GO:0031623 9 6 0,000 0,05269597 0,134518 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05269597 0,13436887 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05269597 0,13422007 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05269597 0,13407159 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05269597 0,13392345 ! protein deubiquitination GO:0016579 8 6 0,000 0,05269597 0,13377563 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05269597 0,13362814 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05269597 0,13348097 ! axonal fasciculation GO:0007413 9 6 0,000 0,05269597 0,13333413 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05269597 0,13318761 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05269597 0,13304141 ! midbrain development GO:0030901 6 6 0,000 0,05269597 0,13289553 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05269597 0,13274997 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05269597 0,13260473 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05269597 0,13245981 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05269597 0,1323152 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05269597 0,13217091 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05269597 0,13202693 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05269597 0,13188327 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05269597 0,13173991 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05269597 0,13159687 ! adult feeding behavior GO:0008343 6 6 0,000 0,05269597 0,13145414 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05269597 0,13131172 ! pigment granule transport GO:0051904 12 6 0,000 0,05269597 0,13116961 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05269597 0,13102781 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05269597 0,13088631 ! catecholamine transport GO:0051937 7 6 0,000 0,05269597 0,13074511 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05269597 0,13060423 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05269597 0,13046364 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05269597 0,13032336 ! protein prenylation GO:0018342 10 6 0,000 0,05269597 0,13018337 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05269597 0,13004369 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05269597 0,12990431 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05269597 0,12976523 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05269597 0,12962644 ! response to oxidative stress GO:0006979 141 94 2,000 0,05270574 0,12951196 ! mitochondrial transport GO:0006839 60 42 1,000 0,05461458 0,13405926 ! cellular component disassembly GO:0022411 64 42 1,000 0,05461458 0,13391634 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,05461458 0,13377373 ! hexose transport GO:0008645 54 42 1,000 0,05461458 0,13363142 GO:0015749|monosaccharide transport, ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,05461458 0,13348941 ! regulation of cell shape GO:0008360 78 42 1,000 0,05461458 0,1333477 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 2,000 0,05546918 0,13529067 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,05546918 0,13514736 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,05546918 0,13500435 ! positive regulation of binding GO:0051099 59 43 1,000 0,05694985 0,13846159 ! methylation GO:0032259 64 43 1,000 0,05694985 0,13831538 ! glycolysis GO:0006096 53 44 1,000 0,05931948 0,14391857 ! regulation of action potential GO:0001508 71 44 1,000 0,05931948 0,14376692 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,06119924 0,14816658 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06120631 0,14802787 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06120631 0,14787238 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06120631 0,14771722 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,06120631 0,14756238 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06120631 0,14740786 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06120631 0,14725367 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06120631 0,1470998 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06120631 0,14694625 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06120631 0,14679302 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06120631 0,14664011 ! reproductive behavior GO:0019098 12 7 0,000 0,06120631 0,14648752 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06120631 0,14633525 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06120631 0,14618329 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,06120631 0,14603165 ! oligopeptide transport GO:0006857 11 7 0,000 0,06120631 0,14588032 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06120631 0,1457293 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06120631 0,1455786 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06120631 0,14542821 ! RNA methylation GO:0001510 11 7 0,000 0,06120631 0,14527813 ! pericardium development GO:0060039 8 7 0,000 0,06120631 0,14512836 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06120631 0,1449789 ! fibril organization GO:0043206 13 7 0,000 0,06120631 0,14482974 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,06120631 0,14468089 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06120631 0,14453235 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,06120631 0,14438411 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06120631 0,14423618 ! lipoprotein transport GO:0042953 9 7 0,000 0,06120631 0,14408854 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06120631 0,14394121 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06120631 0,14379419 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06120631 0,14364746 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06120631 0,14350103 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06120631 0,1433549 ! chemosensory behavior GO:0007635 9 7 0,000 0,06120631 0,14320906 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06120631 0,14306352 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06120631 0,14291828 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06120631 0,14277333 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06120631 0,14262868 ! reflex GO:0060004 12 7 0,000 0,06120631 0,14248432 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06120631 0,14234025 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06120631 0,14219647 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06120631 0,14205298 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06120631 0,14190979 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06120631 0,14176688 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06120631 0,14162425 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06120631 0,14148192 ! adrenal gland development GO:0030325 17 7 0,000 0,06120631 0,14133987 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06120631 0,1411981 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06120631 0,14105662 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06120631 0,14091542 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06120631 0,14077451 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06120631 0,14063387 ! endosome organization GO:0007032 10 7 0,000 0,06120631 0,14049352 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06120631 0,14035345 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06120631 0,14021365 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06120631 0,14007414 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,06120631 0,1399349 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06120631 0,13979594 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06120631 0,13965725 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06120631 0,13951884 ! galactose metabolic process GO:0006012 10 7 0,000 0,06120631 0,1393807 ! vesicle fusion GO:0006906 15 7 0,000 0,06120631 0,13924284 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06120631 0,13910524 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,06120631 0,13896792 ! organ growth GO:0035265 11 7 0,000 0,06120631 0,13883088 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06120631 0,1386941 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06120631 0,13855759 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06120631 0,13842134 ! retinol metabolic process GO:0042572 9 7 0,000 0,06120631 0,13828537 ! behavioral fear response GO:0001662 13 7 0,000 0,06120631 0,13814966 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06120631 0,13801422 ! rRNA modification GO:0000154 12 7 0,000 0,06120631 0,13787905 ! protein heterooligomerization GO:0051291 10 7 0,000 0,06120631 0,13774414 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06120631 0,13760949 ! response to UV-B GO:0010224 11 7 0,000 0,06120631 0,13747511 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06120631 0,13734098 ! intermediate filament organization GO:0045109 11 7 0,000 0,06120631 0,13720712 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06120631 0,13707352 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06120631 0,13694018 ! fibrinolysis GO:0042730 9 7 0,000 0,06120631 0,1368071 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,06120631 0,13667428 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06120631 0,13654171 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06120631 0,13640941 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06120631 0,13627736 ! response to tropane GO:0014073 13 7 0,000 0,06120631 0,13614556 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06120631 0,13601402 ! melanosome localization GO:0032400 10 7 0,000 0,06120631 0,13588273 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06120631 0,1357517 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06120631 0,13562091 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06120631 0,13549038 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06120631 0,1353601 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06120631 0,13523007 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06120631 0,1351003 ! mast cell activation GO:0045576 9 7 0,000 0,06120631 0,13497076 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06120631 0,13484148 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06120631 0,13471245 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06120631 0,13458366 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06120631 0,13445512 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06120631 0,13432682 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06120631 0,13419877 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06120631 0,13407096 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06120631 0,13394339 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06120631 0,13381607 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06120631 0,13368899 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06120631 0,13356215 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06120631 0,13343555 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,06120631 0,13330919 ! diuresis GO:0030146 12 7 0,000 0,06120631 0,13318307 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06120631 0,13305719 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06120631 0,13293155 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06120631 0,13280614 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06120631 0,13268097 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06120631 0,13255603 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06120631 0,13243133 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06120631 0,13230687 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06120631 0,13218264 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06120631 0,13205864 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06120631 0,13193487 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,06120631 0,13181134 ! lymph node development GO:0048535 9 7 0,000 0,06120631 0,13168803 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06120631 0,13156496 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06120631 0,13144212 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06120631 0,1313195 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06120631 0,13119712 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06120631 0,13107496 ! ATP catabolic process GO:0006200 10 7 0,000 0,06120631 0,13095303 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06120631 0,13083133 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,06120631 0,13070985 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06120631 0,1305886 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06120631 0,13046757 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06120631 0,13034677 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06120631 0,13022619 ! muscle adaptation GO:0043500 12 7 0,000 0,06120631 0,13010583 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06120631 0,1299857 GO:0006043|glucosamine catabolic process, ! retina homeostasis GO:0001895 9 7 0,000 0,06120631 0,12986578 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06120631 0,12974609 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06120631 0,12962662 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06120631 0,12950737 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06120631 0,12938833 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06120631 0,12926952 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06120631 0,12915092 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06120631 0,12903255 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,06172266 0,13000194 ! cell recognition GO:0008037 58 45 1,000 0,06172266 0,129883 ! cell maturation GO:0048469 60 45 1,000 0,06172266 0,12976428 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,06415861 0,13476238 ! histone modification GO:0016570 68 46 1,000 0,06415861 0,13463942 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,06662656 0,13969106 ! covalent chromatin modification GO:0016569 75 47 1,000 0,06662656 0,13956383 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,06662656 0,13943684 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,06662656 0,13931008 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,06912574 0,14440436 ! heart morphogenesis GO:0003007 65 48 1,000 0,06912574 0,14427333 ! nuclear export GO:0051168 69 48 1,000 0,06912574 0,14414252 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,06912574 0,14401196 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06964068 0,14495345 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06964068 0,14482239 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,06964068 0,14469156 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,06964068 0,14456097 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06964068 0,14443062 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06964068 0,1443005 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06964068 0,14417062 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06964068 0,14404097 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06964068 0,14391155 ! phosphate transport GO:0006817 10 8 0,000 0,06964068 0,14378237 ! N-glycan processing GO:0006491 12 8 0,000 0,06964068 0,14365342 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06964068 0,14352469 ! UTP metabolic process GO:0046051 8 8 0,000 0,06964068 0,1433962 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06964068 0,14326794 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06964068 0,14313991 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06964068 0,14301211 ! succinate metabolic process GO:0006105 14 8 0,000 0,06964068 0,14288453 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06964068 0,14275718 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,06964068 0,14263006 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06964068 0,14250317 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06964068 0,1423765 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06964068 0,14225005 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06964068 0,14212383 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06964068 0,14199784 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06964068 0,14187206 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06964068 0,14174651 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06964068 0,14162118 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06964068 0,14149608 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06964068 0,14137119 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06964068 0,14124652 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06964068 0,14112208 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06964068 0,14099785 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06964068 0,14087384 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06964068 0,14075005 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06964068 0,14062648 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06964068 0,14050312 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06964068 0,14037998 ! melanin metabolic process GO:0006582 12 8 0,000 0,06964068 0,14025706 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06964068 0,14013435 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06964068 0,14001185 ! macrophage activation GO:0042116 12 8 0,000 0,06964068 0,13988957 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06964068 0,1397675 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06964068 0,13964565 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06964068 0,13952401 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06964068 0,13940257 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06964068 0,13928135 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06964068 0,13916035 ! ruffle organization GO:0031529 11 8 0,000 0,06964068 0,13903955 ! osteoblast development GO:0002076 13 8 0,000 0,06964068 0,13891896 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06964068 0,13879858 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06964068 0,13867841 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06964068 0,13855844 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06964068 0,13843868 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06964068 0,13831913 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06964068 0,13819979 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,06964068 0,13808065 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06964068 0,13796172 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06964068 0,13784299 ! brain morphogenesis GO:0048854 20 8 0,000 0,06964068 0,13772447 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06964068 0,13760615 ! segment specification GO:0007379 10 8 0,000 0,06964068 0,13748803 ! cellular extravasation GO:0045123 11 8 0,000 0,06964068 0,13737012 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06964068 0,13725241 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06964068 0,1371349 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06964068 0,13701759 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06964068 0,13690048 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06964068 0,13678357 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06964068 0,13666686 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,06964068 0,13655035 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06964068 0,13643404 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06964068 0,13631792 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06964068 0,13620201 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06964068 0,13608629 ! icosanoid secretion GO:0032309 12 8 0,000 0,06964068 0,13597076 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06964068 0,13585544 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06964068 0,1357403 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06964068 0,13562537 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06964068 0,13551062 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06964068 0,13539608 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06964068 0,13528172 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06964068 0,13516756 ! sterol catabolic process GO:0016127 9 8 0,000 0,06964068 0,13505359 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06964068 0,13493981 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06964068 0,13482623 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06964068 0,13471283 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06964068 0,13459963 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06964068 0,13448661 ! prophase GO:0051324 11 8 0,000 0,06964068 0,13437379 ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06964068 0,13426116 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06964068 0,13414871 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06964068 0,13403645 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06964068 0,13392438 ! hormone catabolic process GO:0042447 13 8 0,000 0,06964068 0,1338125 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06964068 0,1337008 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,06964068 0,13358929 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06964068 0,13347796 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06964068 0,13336683 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06964068 0,13325587 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,06964068 0,1331451 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06964068 0,13303452 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06964068 0,13292411 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06964068 0,1328139 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06964068 0,13270386 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06964068 0,132594 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06964068 0,13248433 ! regulation of embryonic development GO:0045995 16 8 0,000 0,06964068 0,13237484 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06964068 0,13226553 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06964068 0,1321564 ! RNA elongation GO:0006354 62 49 1,000 0,0716554 0,13586763 ! germ cell development GO:0007281 68 49 1,000 0,0716554 0,13575571 ! maintenance of location GO:0051235 84 49 1,000 0,0716554 0,13564398 ! membrane fusion GO:0006944 80 50 1,000 0,07421481 0,1403734 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,07421481 0,14025806 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,07680322 0,14503072 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,07680322 0,14491174 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,07799975 0,14704871 ! regulation of developmental growth GO:0048638 13 9 0,000 0,07799975 0,14692827 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07799975 0,14680804 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,07799975 0,146688 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07799975 0,14656816 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07799975 0,14644851 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,07799975 0,14632906 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,07799975 0,1462098 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,07799975 0,14609073 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,07799975 0,14597187 ! GTP metabolic process GO:0046039 9 9 0,000 0,07799975 0,14585319 ! social behavior GO:0035176 14 9 0,000 0,07799975 0,14573471 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,07799975 0,14561641 ! artery development GO:0060840 19 9 0,000 0,07799975 0,14549831 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,07799975 0,14538041 ! response to pain GO:0048265 16 9 0,000 0,07799975 0,14526269 ! protein complex disassembly GO:0043241 17 9 0,000 0,07799975 0,14514516 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,07799975 0,14502783 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,07799975 0,14491068 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07799975 0,14479372 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07799975 0,14467695 ! protein targeting to ER GO:0045047 19 9 0,000 0,07799975 0,14456037 ! T cell selection GO:0045058 18 9 0,000 0,07799975 0,14444398 ! endoderm development GO:0007492 12 9 0,000 0,07799975 0,14432777 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07799975 0,14421175 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07799975 0,14409592 ! arginine catabolic process GO:0006527 10 9 0,000 0,07799975 0,14398027 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,07799975 0,14386481 ! L-serine metabolic process GO:0006563 13 9 0,000 0,07799975 0,14374954 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,07799975 0,14363445 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,07799975 0,14351954 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,07799975 0,14340481 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07799975 0,14329027 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,07799975 0,14317592 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07799975 0,14306174 ! mannose metabolic process GO:0006013 9 9 0,000 0,07799975 0,14294775 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,07799975 0,14283393 ! receptor clustering GO:0043113 15 9 0,000 0,07799975 0,1427203 ! epithelial cell development GO:0002064 10 9 0,000 0,07799975 0,14260685 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07799975 0,14249358 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07799975 0,14238049 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,07799975 0,14226758 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07799975 0,14215485 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07799975 0,1420423 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,07799975 0,14192992 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,07799975 0,14181773 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07799975 0,1417057 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,07799975 0,14159386 ! blastoderm segmentation GO:0007350 11 9 0,000 0,07799975 0,14148219 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,07799975 0,1413707 ! DNA ligation GO:0006266 14 9 0,000 0,07799975 0,14125939 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07799975 0,14114825 ! response to amine stimulus GO:0014075 13 9 0,000 0,07799975 0,14103728 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07799975 0,14092649 ! erythrocyte development GO:0048821 11 9 0,000 0,07799975 0,14081587 ! renal water homeostasis GO:0003091 14 9 0,000 0,07799975 0,14070543 ! postreplication repair GO:0006301 11 9 0,000 0,07799975 0,14059516 ! mRNA cleavage GO:0006379 13 9 0,000 0,07799975 0,14048506 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,07799975 0,14037513 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,07799975 0,14026538 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07799975 0,1401558 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,07799975 0,14004639 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07799975 0,13993715 ! acid secretion GO:0046717 14 9 0,000 0,07799975 0,13982808 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07799975 0,13971918 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07799975 0,13961045 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07799975 0,13950188 ! purine base metabolic process GO:0006144 18 9 0,000 0,07799975 0,13939349 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07799975 0,13928527 ! spleen development GO:0048536 15 9 0,000 0,07799975 0,13917721 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,07799975 0,13906932 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,07799975 0,1389616 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07799975 0,13885404 ! detection of calcium ion GO:0005513 13 9 0,000 0,07799975 0,13874665 ! blastocyst formation GO:0001825 12 9 0,000 0,07799975 0,13863943 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07799975 0,13853237 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07799975 0,13842548 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07799975 0,13831875 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,07799975 0,13821219 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07799975 0,13810579 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07799975 0,13799956 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,07799975 0,13789348 ! prepulse inhibition GO:0060134 14 9 0,000 0,07799975 0,13778757 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,07799975 0,13768183 ! insulin secretion GO:0030073 17 9 0,000 0,07799975 0,13757624 ! sequestering of metal ion GO:0051238 11 9 0,000 0,07799975 0,13747082 ! response to nicotine GO:0035094 16 9 0,000 0,07799975 0,13736556 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07799975 0,13726046 ! nucleus localization GO:0051647 15 9 0,000 0,07799975 0,13715552 ! regulation of synapse organization GO:0050807 12 9 0,000 0,07799975 0,13705074 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,07941993 0,13943957 ! establishment of organelle localization GO:0051656 85 52 1,000 0,07941993 0,13933321 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,08206422 0,14386258 ! single fertilization GO:0007338 59 53 1,000 0,08206422 0,14375301 ! cell projection assembly GO:0030031 76 53 1,000 0,08206422 0,14364361 ! glucose catabolic process GO:0006007 66 54 1,000 0,08473539 0,14820639 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,08473539 0,14809377 ! DNA catabolic process GO:0006308 67 54 1,000 0,08473539 0,14798132 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,08473539 0,14786904 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,08473539 0,14775693 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,08628419 0,15034366 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,08628419 0,15022985 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,08628419 0,15011622 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,08628419 0,15000275 ! synapsis GO:0007129 13 10 0,000 0,08628419 0,14988945 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,08628419 0,14977633 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,08628419 0,14966338 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,08628419 0,14955059 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,08628419 0,14943798 ! sulfate transport GO:0008272 12 10 0,000 0,08628419 0,14932554 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,08628419 0,14921326 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,08628419 0,14910115 ! androgen metabolic process GO:0008209 13 10 0,000 0,08628419 0,14898922 ! phospholipid efflux GO:0033700 16 10 0,000 0,08628419 0,14887745 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,08628419 0,14876584 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,08628419 0,14865441 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,08628419 0,14854314 ! pathogenesis GO:0009405 13 10 0,000 0,08628419 0,14843204 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,08628419 0,1483211 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,08628419 0,14821033 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,08628419 0,14809973 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,08628419 0,14798929 ! melanocyte differentiation GO:0030318 15 10 0,000 0,08628419 0,14787901 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,08628419 0,1477689 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,08628419 0,14765896 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,08628419 0,14754917 ! B cell proliferation GO:0042100 14 10 0,000 0,08628419 0,14743955 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,08628419 0,14733009 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,08628419 0,1472208 ! forebrain cell migration GO:0021885 17 10 0,000 0,08628419 0,14711167 ! lipid digestion GO:0044241 15 10 0,000 0,08628419 0,14700269 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,08628419 0,14689388 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,08628419 0,14678523 ! UV protection GO:0009650 14 10 0,000 0,08628419 0,14667675 ! fear response GO:0042596 16 10 0,000 0,08628419 0,14656842 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,08628419 0,14646025 ! negative regulation of ossification GO:0030279 19 10 0,000 0,08628419 0,14635224 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,08628419 0,14624439 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,08628419 0,1461367 ! regulation of organ growth GO:0046620 11 10 0,000 0,08628419 0,14602917 ! response to dsRNA GO:0043331 18 10 0,000 0,08628419 0,14592179 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,08628419 0,14581458 ! embryonic axis specification GO:0000578 12 10 0,000 0,08628419 0,14570752 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,08628419 0,14560061 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,08628419 0,14549387 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,08628419 0,14538728 ! fucose catabolic process GO:0019317 16 10 0,000 0,08628419 0,14528085 GO:0042355|L-fucose catabolic process, ! protein sumoylation GO:0016925 12 10 0,000 0,08628419 0,14517457 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,08628419 0,14506845 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,08628419 0,14496248 ! zymogen activation GO:0031638 14 10 0,000 0,08628419 0,14485667 ! salivary gland development GO:0007431 22 10 0,000 0,08628419 0,14475101 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,08628419 0,14464551 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,08628419 0,14454016 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,08628419 0,14443496 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,08628419 0,14432992 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,08628419 0,14422503 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,08628419 0,14412029 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,08628419 0,1440157 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,08628419 0,14391127 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,08628419 0,14380698 ! detection of bacterium GO:0016045 10 10 0,000 0,08628419 0,14370285 ! activation of innate immune response GO:0002218 10 10 0,000 0,08628419 0,14359887 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,08628419 0,14349504 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,08628419 0,14339136 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,08628419 0,14328782 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,08628419 0,14318444 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,08628419 0,14308121 ! mesoderm development GO:0007498 76 55 1,000 0,08743276 0,14488137 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,09015564 0,14928579 ! carbohydrate transport GO:0008643 74 57 1,000 0,09290337 0,153725 ! chromosome segregation GO:0007059 83 57 1,000 0,09290337 0,15361448 ! camera-type eye development GO:0043010 88 57 1,000 0,09290337 0,15350413 ! secondary metabolic process GO:0019748 84 57 1,000 0,09290337 0,15339393 ! developmental maturation GO:0021700 75 57 1,000 0,09290337 0,15328389 ! gonad development GO:0008406 79 57 1,000 0,09290337 0,15317401 ! rRNA transcription GO:0009303 17 11 0,000 0,09449466 0,15568605 ! respiratory burst GO:0045730 14 11 0,000 0,09449466 0,15557461 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,09449466 0,15546332 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,09449466 0,1553522 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,09449466 0,15524123 ! virus-host interaction GO:0019048 17 11 0,000 0,09449466 0,15513042 ! filopodium assembly GO:0046847 19 11 0,000 0,09449466 0,15501977 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,09449466 0,15490928 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,09449466 0,15479895 ! mating GO:0007618 14 11 0,000 0,09449466 0,15468877 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,09449466 0,15457875 ! T cell proliferation GO:0042098 20 11 0,000 0,09449466 0,15446889 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,09449466 0,15435918 ! bone resorption GO:0045453 16 11 0,000 0,09449466 0,15424963 ! regulated secretory pathway GO:0045055 14 11 0,000 0,09449466 0,15414023 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,09449466 0,15403099 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,09449466 0,1539219 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,09449466 0,15381297 ! syncytium formation GO:0006949 15 11 0,000 0,09449466 0,15370419 ! plasma membrane organization GO:0007009 18 11 0,000 0,09449466 0,15359556 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,09449466 0,15348709 ! mitotic spindle organization GO:0007052 15 11 0,000 0,09449466 0,15337878 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,09449466 0,15327061 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,09449466 0,1531626 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,09449466 0,15305474 ! adult heart development GO:0007512 11 11 0,000 0,09449466 0,15294703 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,09449466 0,15283947 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,09449466 0,15273206 ! temperature homeostasis GO:0001659 16 11 0,000 0,09449466 0,15262481 ! L-glutamate transport GO:0015813 16 11 0,000 0,09449466 0,1525177 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,09449466 0,15241075 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,09449466 0,15230394 ! stem cell development GO:0048864 29 11 0,000 0,09449466 0,15219729 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,09449466 0,15209078 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,09449466 0,15198442 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,09449466 0,15187821 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,09449466 0,15177215 ! vasoconstriction GO:0042310 15 11 0,000 0,09449466 0,15166624 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,09449466 0,15156048 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,09449466 0,15145486 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,09449466 0,15134939 ! ribosome assembly GO:0042255 13 11 0,000 0,09449466 0,15124407 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,09449466 0,15113889 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,09449466 0,15103386 ! chromatin silencing GO:0006342 19 11 0,000 0,09449466 0,15092898 ! nucleosome positioning GO:0016584 13 11 0,000 0,09449466 0,15082424 ! T cell homeostasis GO:0043029 20 11 0,000 0,09449466 0,15071964 ! regulation of isotype switching GO:0045191 19 11 0,000 0,09449466 0,15061519 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,09449466 0,15051089 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,09449466 0,15040673 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,09449466 0,15030271 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,09449466 0,15019884 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,09449466 0,15009511 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,09449466 0,14999153 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,09449466 0,14988809 ! male genitalia development GO:0030539 13 11 0,000 0,09449466 0,14978479 ! cholesterol efflux GO:0033344 19 11 0,000 0,09449466 0,14968163 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,09449466 0,14957861 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,09449466 0,14947574 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,09449466 0,14937301 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,09449466 0,14927042 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,09449466 0,14916796 ! defense response to fungus GO:0050832 12 11 0,000 0,09449466 0,14906565 ! lysogeny GO:0030069 18 11 0,000 0,09449466 0,14896348 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,09449466 0,14886146 ! acrosome reaction GO:0007340 13 11 0,000 0,09449466 0,14875956 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,09449466 0,14865781 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,09567528 0,15041227 ! activation of MAPK activity GO:0000187 84 59 1,000 0,09847074 0,1547013 ! actin filament organization GO:0007015 95 59 1,000 0,09847074 0,1545957 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,09847074 0,15449025 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,1012891 0,15880363 ! fertilization GO:0009566 68 60 1,000 0,1012891 0,15869545 ! lactation GO:0007595 20 12 0,000 0,10263182 0,16068972 ! reproductive cellular process GO:0048610 14 12 0,000 0,10263182 0,1605804 ! tRNA modification GO:0006400 14 12 0,000 0,10263182 0,16047124 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,10263182 0,16036222 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,10263182 0,16025336 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,10263182 0,16014464 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,10263182 0,16003606 ! phospholipid catabolic process GO:0009395 14 12 0,000 0,10263182 0,15992764 ! peroxisomal transport GO:0043574 21 12 0,000 0,10263182 0,15981936 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,10263182 0,15971123 ! palate development GO:0060021 15 12 0,000 0,10263182 0,15960324 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,10263182 0,1594954 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,10263182 0,15938771 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,10263182 0,15928016 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,10263182 0,15917275 ! arginine metabolic process GO:0006525 13 12 0,000 0,10263182 0,15906549 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,10263182 0,15895838 ! methionine metabolic process GO:0006555 13 12 0,000 0,10263182 0,15885141 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,10263182 0,15874458 ! Golgi organization GO:0007030 18 12 0,000 0,10263182 0,1586379 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,10263182 0,15853136 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,10263182 0,15842496 ! monoamine transport GO:0015844 13 12 0,000 0,10263182 0,15831871 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,10263182 0,1582126 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,10263182 0,15810663 ! L-amino acid transport GO:0015807 20 12 0,000 0,10263182 0,1580008 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,10263182 0,15789511 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,10263182 0,15778957 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,10263182 0,15768416 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,10263182 0,1575789 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,10263182 0,15747378 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,10263182 0,1573688 ! cerebellum development GO:0021549 13 12 0,000 0,10263182 0,15726395 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,10263182 0,15715925 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,10263182 0,15705469 ! histone methylation GO:0016571 15 12 0,000 0,10263182 0,15695026 ! gland morphogenesis GO:0022612 23 12 0,000 0,10263182 0,15684598 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,10263182 0,15674183 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,10263182 0,15663782 ! regulation of epidermis development GO:0045682 17 12 0,000 0,10263182 0,15653395 ! intestinal absorption GO:0050892 19 12 0,000 0,10263182 0,15643021 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,10263182 0,15632662 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,10263182 0,15622316 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,10263182 0,15611984 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,10263182 0,15601665 ! microspike assembly GO:0030035 23 12 0,000 0,10263182 0,1559136 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,10263182 0,15581069 ! response to cold GO:0009409 14 12 0,000 0,10263182 0,15570791 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,10412972 0,15787631 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,10412972 0,15777231 ! organelle localization GO:0051640 96 62 1,000 0,106992 0,16200237 ! regulation of lipase activity GO:0060191 109 63 1,000 0,10987531 0,16625869 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,11069632 0,16739089 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11069632 0,16728091 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11069632 0,16717107 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,11069632 0,16706138 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11069632 0,16695183 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11069632 0,16684243 ! lipid localization GO:0010876 24 13 0,000 0,11069632 0,16673316 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11069632 0,16662405 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11069632 0,16651507 ! organelle fusion GO:0048284 28 13 0,000 0,11069632 0,16640624 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11069632 0,16629755 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11069632 0,166189 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,11069632 0,16608059 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11069632 0,16597232 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11069632 0,1658642 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,11069632 0,16575621 ! glutamate metabolic process GO:0006536 18 13 0,000 0,11069632 0,16564837 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11069632 0,16554067 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,11069632 0,1654331 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! NAD metabolic process GO:0019674 21 13 0,000 0,11069632 0,16532568 ! exocrine system development GO:0035272 27 13 0,000 0,11069632 0,16521839 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,11069632 0,16511125 ! bone mineralization GO:0030282 15 13 0,000 0,11069632 0,16500424 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11069632 0,16489737 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11069632 0,16479064 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11069632 0,16468405 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11069632 0,1645776 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11069632 0,16447128 ! genitalia development GO:0048806 15 13 0,000 0,11069632 0,1643651 ! cellular pigmentation GO:0033059 24 13 0,000 0,11069632 0,16425906 ! tissue regeneration GO:0042246 21 13 0,000 0,11069632 0,16415315 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11069632 0,16404739 ! cofactor transport GO:0051181 19 13 0,000 0,11069632 0,16394175 ! NADP metabolic process GO:0006739 18 13 0,000 0,11069632 0,16383626 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11069632 0,1637309 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11069632 0,16362567 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11069632 0,16352058 ! gas transport GO:0015669 18 13 0,000 0,11069632 0,16341562 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11069632 0,1633108 ! regulation of axon extension GO:0030516 23 13 0,000 0,11069632 0,16320612 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,11069632 0,16310156 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,11069632 0,16299715 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11069632 0,16289286 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11069632 0,16278871 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11069632 0,16268469 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11069632 0,16258081 ! hexose catabolic process GO:0019320 82 64 1,000 0,11277906 0,16553403 ! adaptive immune response GO:0002250 94 64 1,000 0,11277906 0,16542846 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,11570264 0,16960872 ! B cell activation GO:0042113 104 65 1,000 0,11570264 0,16950069 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,11570264 0,16939279 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,11868881 0,1736541 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,11868881 0,17354371 ! superoxide anion generation GO:0042554 18 14 0,000 0,11868881 0,17343345 ! neuron maturation GO:0042551 21 14 0,000 0,11868881 0,17332334 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,11868881 0,17321336 ! myotube differentiation GO:0014902 21 14 0,000 0,11868881 0,17310352 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,11868881 0,17299382 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,11868881 0,17288426 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,11868881 0,17277484 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,11868881 0,17266556 ! gene silencing by RNA GO:0031047 20 14 0,000 0,11868881 0,17255642 ! response to cAMP GO:0051591 19 14 0,000 0,11868881 0,17244741 ! startle response GO:0001964 21 14 0,000 0,11868881 0,17233854 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,11868881 0,17222981 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,11868881 0,17212122 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,11868881 0,17201276 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,11868881 0,17190444 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,11868881 0,17179626 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,11868881 0,17168821 ! glycine metabolic process GO:0006544 22 14 0,000 0,11868881 0,1715803 ! pituitary gland development GO:0021983 23 14 0,000 0,11868881 0,17147252 ! lysosomal transport GO:0007041 20 14 0,000 0,11868881 0,17136488 ! regulation of heart rate GO:0002027 23 14 0,000 0,11868881 0,17125737 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,11868881 0,17115 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,11868881 0,17104276 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,11868881 0,17093566 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,11868881 0,17082869 ! axon cargo transport GO:0008088 27 14 0,000 0,11868881 0,17072186 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,11868881 0,17061516 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,11868881 0,17050859 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,11868881 0,17040216 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,11868881 0,17029585 ! mRNA splice site selection GO:0006376 26 14 0,000 0,11868881 0,17018968 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,11868881 0,17008365 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,11868881 0,16997774 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,11868881 0,16987197 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,11868881 0,16976633 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,11868881 0,16966082 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,11868881 0,16955544 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,11868881 0,16945019 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,11868881 0,16934507 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,11868881 0,16924008 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,11868881 0,16913522 ! cell killing GO:0001906 20 14 0,000 0,11868881 0,1690305 ! cilium assembly GO:0042384 20 14 0,000 0,11868881 0,1689259 ! peptide hormone secretion GO:0030072 23 14 0,000 0,11868881 0,16882143 ! learning or memory GO:0007611 123 68 1,000 0,12458665 0,17710092 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,12458665 0,17699153 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,12458665 0,17688228 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,12660991 0,17964392 ! positive regulation of cell size GO:0045793 20 15 0,000 0,12660991 0,17953316 ! metencephalon development GO:0022037 19 15 0,000 0,12660991 0,17942255 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,12660991 0,17931207 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,12660991 0,17920172 ! skin development GO:0043588 25 15 0,000 0,12660991 0,17909151 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,12660991 0,17898143 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,12660991 0,17887149 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,12660991 0,17876169 ! bile acid metabolic process GO:0008206 22 15 0,000 0,12660991 0,17865202 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,12660991 0,17854249 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,12660991 0,17843308 ! adult walking behavior GO:0007628 25 15 0,000 0,12660991 0,17832382 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,12660991 0,17821468 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,12660991 0,17810568 ! myoblast differentiation GO:0045445 27 15 0,000 0,12660991 0,17799682 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,12660991 0,17788808 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,12660991 0,17777948 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,12660991 0,17767102 ! cerebral cortex development GO:0021987 29 15 0,000 0,12660991 0,17756268 ! response to osmotic stress GO:0006970 22 15 0,000 0,12660991 0,17745448 ! vesicle coating GO:0006901 25 15 0,000 0,12660991 0,1773464 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,12660991 0,17723846 ! DNA integration GO:0015074 22 15 0,000 0,12660991 0,17713065 ! peptide secretion GO:0002790 27 15 0,000 0,12660991 0,17702297 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,12660991 0,17691543 ! regulation of vasodilation GO:0042312 24 15 0,000 0,12660991 0,17680801 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,12660991 0,17670072 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,12660991 0,17659357 ! biomineral formation GO:0031214 18 15 0,000 0,12660991 0,17648654 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,12660991 0,17637964 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,12660991 0,17627288 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,12660991 0,17616624 ! dopamine metabolic process GO:0042417 30 15 0,000 0,12660991 0,17605973 ! organic cation transport GO:0015695 19 15 0,000 0,12660991 0,17595335 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,12660991 0,1758471 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,12660991 0,17574097 ! defense response to virus GO:0051607 27 15 0,000 0,12660991 0,17563498 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,13059804 0,18105816 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,13059804 0,18094909 ! eye development GO:0001654 111 70 1,000 0,13059804 0,18084015 ! muscle cell differentiation GO:0042692 104 71 1,000 0,1336287 0,18492539 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,1336287 0,18481419 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,1336287 0,18470313 ! hormone secretion GO:0046879 25 16 0,000 0,13446027 0,18574091 ! bone remodeling GO:0046849 24 16 0,000 0,13446027 0,18562943 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,13446027 0,18551807 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,13446027 0,18540685 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,13446027 0,18529576 ! glial cell development GO:0021782 24 16 0,000 0,13446027 0,1851848 ! patterning of blood vessels GO:0001569 24 16 0,000 0,13446027 0,18507398 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,13446027 0,18496329 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,13446027 0,18485273 ! protein polyubiquitination GO:0000209 26 16 0,000 0,13446027 0,18474231 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,13446027 0,18463201 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,13446027 0,18452185 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,13446027 0,18441182 ! fructose metabolic process GO:0006000 20 16 0,000 0,13446027 0,18430192 ! regulation of protein binding GO:0043393 27 16 0,000 0,13446027 0,18419215 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,13446027 0,18408251 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,13446027 0,18397301 ! protein export from nucleus GO:0006611 24 16 0,000 0,13446027 0,18386363 ! negative regulation of immune response GO:0050777 28 16 0,000 0,13446027 0,18375438 ! DNA replication initiation GO:0006270 25 16 0,000 0,13446027 0,18364526 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,13446027 0,18353627 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,13446027 0,18342742 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,13446027 0,18331869 ! diencephalon development GO:0021536 25 16 0,000 0,13446027 0,18321008 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,13446027 0,18310161 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,13446027 0,18299327 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,13446027 0,18288505 ! steroid catabolic process GO:0006706 22 16 0,000 0,13446027 0,18277696 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,13446027 0,182669 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,13446027 0,18256117 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,13446027 0,18245346 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,13446027 0,18234589 ! sperm-egg recognition GO:0035036 16 16 0,000 0,13446027 0,18223843 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,13446027 0,18213111 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,13446027 0,18202391 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,13446027 0,18191684 ! negative regulation of translation GO:0017148 22 16 0,000 0,13446027 0,18180989 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,13667529 0,18469634 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of blood pressure GO:0008217 107 73 1,000 0,13973728 0,18872328 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,13973728 0,18861253 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,14224051 0,1918787 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,14224051 0,19176623 ! negative regulation of defense response GO:0031348 19 17 0,000 0,14224051 0,19165389 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,14224051 0,19154168 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,14224051 0,1914296 ! glycerol metabolic process GO:0006071 20 17 0,000 0,14224051 0,19131765 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,14224051 0,19120583 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,14224051 0,19109415 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,14224051 0,19098259 ! signal complex assembly GO:0007172 29 17 0,000 0,14224051 0,19087117 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,14224051 0,19075987 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,14224051 0,19064871 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,14224051 0,19053767 ! keratinization GO:0031424 17 17 0,000 0,14224051 0,19042677 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,14224051 0,19031599 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,14224051 0,19020534 ! retinoid metabolic process GO:0001523 22 17 0,000 0,14224051 0,19009482 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,14224051 0,18998443 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,14224051 0,18987416 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,14224051 0,18976403 ! vacuolar transport GO:0007034 24 17 0,000 0,14224051 0,18965402 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,14224051 0,18954414 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,14224051 0,18943439 ! membrane budding GO:0006900 29 17 0,000 0,14224051 0,18932476 ! heme metabolic process GO:0042168 27 17 0,000 0,14224051 0,18921526 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,14224051 0,18910589 ! body fluid secretion GO:0007589 27 17 0,000 0,14224051 0,18899664 ! stem cell differentiation GO:0048863 36 17 0,000 0,14224051 0,18888752 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,14224051 0,18877852 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,14224051 0,18866966 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,14224051 0,18856091 ! sensory perception of pain GO:0019233 23 17 0,000 0,14224051 0,18845229 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,14224051 0,1883438 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,14224051 0,18823543 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,14224051 0,18812719 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,14224051 0,18801907 ! cell-cell junction organization GO:0045216 25 17 0,000 0,14224051 0,18791108 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,14224051 0,1878032 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,14224051 0,18769546 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,14224051 0,18758783 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,14224051 0,18748033 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,14281416 0,18812862 ! tRNA metabolic process GO:0006399 95 76 1,000 0,14901056 0,19617875 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,14901056 0,19606652 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,14995126 0,19719148 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,14995126 0,1970788 ! positive regulation of translation GO:0045727 28 18 0,000 0,14995126 0,19696625 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,14995126 0,19685383 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,14995126 0,19674153 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,14995126 0,19662937 ! cAMP metabolic process GO:0046058 33 18 0,000 0,14995126 0,19651733 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,14995126 0,19640541 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,14995126 0,19629363 ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,14995126 0,19618197 ! pancreas development GO:0031016 26 18 0,000 0,14995126 0,19607044 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,14995126 0,19595904 ! glutamine metabolic process GO:0006541 23 18 0,000 0,14995126 0,19584776 ! pigmentation during development GO:0048066 31 18 0,000 0,14995126 0,19573661 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,14995126 0,19562559 ! fucose metabolic process GO:0006004 26 18 0,000 0,14995126 0,19551469 ! response to fungus GO:0009620 19 18 0,000 0,14995126 0,19540391 ! peptide cross-linking GO:0018149 31 18 0,000 0,14995126 0,19529327 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,14995126 0,19518274 ! heart process GO:0003015 27 18 0,000 0,14995126 0,19507235 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,14995126 0,19496207 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,14995126 0,19485192 ! visual learning GO:0008542 35 18 0,000 0,14995126 0,1947419 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,14995126 0,194632 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,14995126 0,19452223 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,14995126 0,19441257 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,14995126 0,19430305 ! vitamin transport GO:0051180 24 18 0,000 0,14995126 0,19419364 ! hormone transport GO:0009914 27 18 0,000 0,14995126 0,19408436 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,14995126 0,1939752 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,14995126 0,19386616 ! cell-cell recognition GO:0009988 20 18 0,000 0,14995126 0,19375725 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,14995126 0,19364846 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,14995126 0,19353979 ! regulation of glucose import GO:0046324 21 18 0,000 0,14995126 0,19343124 GO:0010827|regulation of glucose transport, ! sex differentiation GO:0007548 105 77 1,000 0,15212907 0,19613053 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,15212907 0,19602065 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,15759314 0,20294749 ! positive regulation of ossification GO:0045778 30 19 0,000 0,15759314 0,20283392 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,15759314 0,20272048 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,15759314 0,20260716 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,15759314 0,20249397 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,15759314 0,20238091 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,15759314 0,20226798 ! regeneration GO:0031099 32 19 0,000 0,15759314 0,20215517 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,15759314 0,20204248 ! response to alkaloid GO:0043279 32 19 0,000 0,15759314 0,20192992 ! sensory perception of taste GO:0050909 23 19 0,000 0,15759314 0,20181749 ! smooth muscle contraction GO:0006939 36 19 0,000 0,15759314 0,20170518 ! peroxisome organization GO:0007031 29 19 0,000 0,15759314 0,201593 ! digestive system process GO:0022600 30 19 0,000 0,15759314 0,20148094 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,15759314 0,20136901 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,15759314 0,2012572 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,15759314 0,20114551 ! sex determination GO:0007530 29 19 0,000 0,15759314 0,20103395 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,15759314 0,20092251 ! cytolysis GO:0019835 20 19 0,000 0,15759314 0,2008112 ! vasodilation GO:0042311 33 19 0,000 0,15759314 0,20070001 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,15759314 0,20058894 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,15759314 0,20047799 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,15759314 0,20036717 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,15759314 0,20025647 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,15759314 0,20014589 ! sarcomere organization GO:0045214 23 19 0,000 0,15759314 0,20003544 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,15759314 0,1999251 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,15759314 0,19981489 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,15759314 0,1997048 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,15759314 0,19959483 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,15759314 0,19948498 ! protein stabilization GO:0050821 26 19 0,000 0,15759314 0,19937525 ! T cell activation GO:0042110 134 79 1,000 0,15840431 0,20029132 ! alcohol catabolic process GO:0046164 104 80 1,000 0,16156009 0,20416934 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,16472734 0,2080576 GO:0002696|positive regulation of leukocyte activation, ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,16516674 0,20849808 ! iron ion transport GO:0006826 37 20 0,000 0,16516674 0,20838371 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,16516674 0,20826947 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,16516674 0,20815535 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,16516674 0,20804135 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,16516674 0,20792748 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,16516674 0,20781373 ! response to ethanol GO:0045471 37 20 0,000 0,16516674 0,20770011 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,16516674 0,20758662 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,16516674 0,20747324 ! chromosome condensation GO:0030261 31 20 0,000 0,16516674 0,20735999 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,16516674 0,20724687 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,16516674 0,20713386 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,16516674 0,20702098 ! collagen fibril organization GO:0030199 45 20 0,000 0,16516674 0,20690823 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,16516674 0,20679559 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,16516674 0,20668308 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,16516674 0,20657069 ! collagen catabolic process GO:0030574 25 20 0,000 0,16516674 0,20645843 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,16516674 0,20634628 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,16516674 0,20623426 ! alditol metabolic process GO:0019400 24 20 0,000 0,16516674 0,20612236 ! actin filament-based movement GO:0030048 34 20 0,000 0,16516674 0,20601058 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,17267269 0,21525592 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,17267269 0,21513932 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,17267269 0,21502284 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,17267269 0,21490648 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,17267269 0,21479025 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,17267269 0,21467415 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,17267269 0,21455817 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,17267269 0,21444232 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,17267269 0,21432659 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,17267269 0,21421099 ! vesicle docking GO:0048278 27 21 0,000 0,17267269 0,21409552 ! phototransduction GO:0007602 25 21 0,000 0,17267269 0,21398016 ! visual behavior GO:0007632 39 21 0,000 0,17267269 0,21386493 ! ovarian follicle development GO:0001541 30 21 0,000 0,17267269 0,21374983 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,17267269 0,21363485 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,17267269 0,21351999 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,17267269 0,21340526 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,17267269 0,21329064 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,17267269 0,21317616 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,17267269 0,21306179 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,17267269 0,21294755 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,17267269 0,21283343 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,17267269 0,21271943 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,17267269 0,21260556 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,17267269 0,2124918 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,17267269 0,21237817 ! fatty acid transport GO:0015908 30 21 0,000 0,17267269 0,21226466 ! immunoglobulin production GO:0002377 33 21 0,000 0,17267269 0,21215127 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,17267269 0,212038 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,17267269 0,21192486 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,17267269 0,21181183 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,17267269 0,21169892 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,17267269 0,21158614 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,17267269 0,21147347 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,17267269 0,21136093 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,17267269 0,2112485 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,17267269 0,21113619 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,17267269 0,21102401 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,17267269 0,21091194 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,17267269 0,21079999 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,17267269 0,21068816 ! rRNA metabolic process GO:0016072 107 85 1,000 0,17750217 0,21646606 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,17750217 0,21635135 ! regulation of membrane potential GO:0042391 128 85 1,000 0,17750217 0,21623675 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,17750217 0,21612228 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,18011157 0,2191834 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,18011157 0,21906749 ! viral genome replication GO:0019079 29 22 0,000 0,18011157 0,2189517 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,18011157 0,21883604 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,18011157 0,2187205 ! molting cycle process GO:0022404 40 22 0,000 0,18011157 0,21860508 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,18011157 0,21848978 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,18011157 0,2183746 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,18011157 0,21825955 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,18011157 0,21814461 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,18011157 0,2180298 ! lysosome organization GO:0007040 37 22 0,000 0,18011157 0,21791511 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,18011157 0,21780054 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,18011157 0,21768608 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,18011157 0,21757175 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,18011157 0,21745754 ! membrane depolarization GO:0051899 35 22 0,000 0,18011157 0,21734345 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,18011157 0,21722948 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,18011157 0,21711563 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,18011157 0,2170019 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,18011157 0,21688828 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,18011157 0,21677479 ! female pregnancy GO:0007565 130 87 1,000 0,18394694 0,22127509 ! protein processing GO:0016485 114 88 1,000 0,18718219 0,22504915 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,18748399 0,22529425 ! embryonic pattern specification GO:0009880 31 23 0,000 0,18748399 0,2251766 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,18748399 0,22505908 ! vesicle targeting GO:0006903 32 23 0,000 0,18748399 0,22494167 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,18748399 0,22482439 ! osteoblast differentiation GO:0001649 40 23 0,000 0,18748399 0,22470724 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,18748399 0,2245902 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,18748399 0,22447329 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,18748399 0,2243565 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,18748399 0,22423983 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,18748399 0,22412328 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,18748399 0,22400685 ! cell fate determination GO:0001709 45 23 0,000 0,18748399 0,22389054 ! pentose metabolic process GO:0019321 31 23 0,000 0,18748399 0,22377436 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,18748399 0,22365829 ! spermatid development GO:0007286 33 23 0,000 0,18748399 0,22354235 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,18748399 0,22342652 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,18748399 0,22331082 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,18748399 0,22319523 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,18748399 0,22307977 ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,18748399 0,22296442 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,18748399 0,22284919 ! regulation of amine transport GO:0051952 38 23 0,000 0,18748399 0,22273408 ! reproductive developmental process GO:0003006 127 89 1,000 0,19042546 0,2261118 ! leukocyte differentiation GO:0002521 143 90 1,000 0,19367635 0,22985326 ! hormone metabolic process GO:0042445 121 90 1,000 0,19367635 0,22973471 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,19479054 0,23093724 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,19479054 0,23081826 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,19479054 0,23069941 ! superoxide metabolic process GO:0006801 32 24 0,000 0,19479054 0,23058067 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,19479054 0,23046206 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,19479054 0,23034357 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,19479054 0,2302252 ! sperm motility GO:0030317 27 24 0,000 0,19479054 0,23010696 ! vacuole organization GO:0007033 39 24 0,000 0,19479054 0,22998883 ! receptor metabolic process GO:0043112 37 24 0,000 0,19479054 0,22987083 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,19479054 0,22975295 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,19479054 0,22963519 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,19479054 0,22951754 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,19479054 0,22940002 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,19479054 0,22928262 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,2020318 0,23768447 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,2020318 0,23756296 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,2020318 0,23744156 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,2020318 0,2373203 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,2020318 0,23719915 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,2020318 0,23707813 ! peptide transport GO:0015833 43 25 0,000 0,2020318 0,23695724 ! male gonad development GO:0008584 33 25 0,000 0,2020318 0,23683646 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,2020318 0,23671581 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,2020318 0,23659529 ! phospholipid transport GO:0015914 35 25 0,000 0,2020318 0,23647488 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,2020318 0,2363546 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,2020318 0,23623444 ! detection of light stimulus GO:0009583 30 25 0,000 0,2020318 0,2361144 ! leukocyte proliferation GO:0070661 39 25 0,000 0,2020318 0,23599449 GO:0032943|mononuclear cell proliferation, ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,20347086 0,23755481 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,20347086 0,23743429 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,20347086 0,23731388 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,20920835 0,24388201 ! translational initiation GO:0006413 43 26 0,000 0,20920835 0,24375846 ! circadian rhythm GO:0007623 42 26 0,000 0,20920835 0,24363504 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,20920835 0,24351174 ! post-embryonic development GO:0009791 42 26 0,000 0,20920835 0,24338857 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,20920835 0,24326552 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,20920835 0,2431426 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,20920835 0,2430198 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,20920835 0,24289712 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,20920835 0,24277457 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,20920835 0,24265214 ! regulation of coagulation GO:0050818 39 26 0,000 0,20920835 0,24252984 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,21332014 0,24717195 ! protein maturation GO:0051604 129 96 1,000 0,21332014 0,24704749 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,21632076 0,25039645 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,21632076 0,2502705 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,21632076 0,25014467 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,21632076 0,25001897 ! membrane docking GO:0022406 39 27 0,000 0,21632076 0,2498934 ! catechol metabolic process GO:0009712 43 27 0,000 0,21632076 0,24976795 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,21632076 0,24964263 ! acute-phase response GO:0006953 42 27 0,000 0,21632076 0,24951743 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,21632076 0,24939236 ! myofibril assembly GO:0030239 36 27 0,000 0,21632076 0,24926741 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,21632076 0,24914259 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,21632076 0,24901789 ! natural killer cell activation GO:0030101 35 27 0,000 0,21632076 0,24889332 ! lipid oxidation GO:0034440 38 27 0,000 0,21632076 0,24876888 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,21632076 0,24864455 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,21632076 0,24852036 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,21632076 0,24839628 ! gene silencing GO:0016458 41 27 0,000 0,21632076 0,24827233 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,22321436 0,25605637 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,22336961 0,25610673 ! phenol metabolic process GO:0018958 44 28 0,000 0,22336961 0,25597912 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,22336961 0,25585165 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,22336961 0,25572429 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,22336961 0,25559707 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,22336961 0,25546997 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,22336961 0,25534299 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,22336961 0,25521615 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,22336961 0,25508943 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,22336961 0,25496283 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,22336961 0,25483636 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,22336961 0,25471002 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,22336961 0,2545838 ! mesoderm formation GO:0001707 46 28 0,000 0,22336961 0,2544577 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,22336961 0,25433173 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,22336961 0,25420589 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,22336961 0,25408017 ! BMP signaling pathway GO:0030509 40 28 0,000 0,22336961 0,25395457 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,22336961 0,2538291 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,22336961 0,25370375 ! regulation of translation GO:0006417 151 100 1,000 0,22652079 0,25715588 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,23035546 0,26138014 ! regulation of innate immune response GO:0045088 38 29 0,000 0,23035546 0,26125126 ! ovulation cycle process GO:0022602 41 29 0,000 0,23035546 0,2611225 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,23035546 0,26099387 ! protein targeting to membrane GO:0006612 53 29 0,000 0,23035546 0,26086536 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,23035546 0,26073698 ! muscle cell development GO:0055001 38 29 0,000 0,23035546 0,26060873 ! formation of primary germ layer GO:0001704 48 29 0,000 0,23035546 0,26048061 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,23035546 0,26035261 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,23035546 0,26022473 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,23727886 0,26791428 ! organic anion transport GO:0015711 51 30 0,000 0,23727886 0,26778282 ! cholesterol transport GO:0030301 46 30 0,000 0,23727886 0,26765149 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,23727886 0,26752029 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,23727886 0,26738921 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,23727886 0,26725827 ! ceramide metabolic process GO:0006672 43 30 0,000 0,23727886 0,26712745 ! ovulation cycle GO:0042698 43 30 0,000 0,23727886 0,26699676 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,23727886 0,2668662 ! adult locomotory behavior GO:0008344 47 30 0,000 0,23727886 0,26673577 ! response to heat GO:0009408 41 30 0,000 0,23727886 0,26660546 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,23727886 0,26647529 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,23727886 0,26634523 ! negative regulation of secretion GO:0051048 49 31 0,000 0,24414038 0,2739136 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,24414038 0,27378005 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,24414038 0,27364663 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,24414038 0,27351333 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,24414038 0,27338017 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,24414038 0,27324714 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,24414038 0,27311424 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,24414038 0,27298147 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,24414038 0,27284882 ! RNA modification GO:0009451 40 31 0,000 0,24414038 0,27271631 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,25094056 0,28017636 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,25094056 0,28004041 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,25094056 0,2799046 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,25094056 0,27976893 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,25094056 0,27963338 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,25094056 0,27949796 ! vesicle localization GO:0051648 47 32 0,000 0,25094056 0,27936268 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,25767995 0,2867266 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,25767995 0,28658795 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,25767995 0,28644944 ! actomyosin structure organization GO:0031032 43 33 0,000 0,25767995 0,28631106 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,25767995 0,28617281 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,25767995 0,28603469 ! lipid homeostasis GO:0055088 55 33 0,000 0,25767995 0,28589671 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,25767995 0,28575887 ! regulation of proteolysis GO:0030162 50 33 0,000 0,25767995 0,28562115 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,25767995 0,28548357 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,25767995 0,28534612 ! mRNA catabolic process GO:0006402 48 34 0,000 0,26435909 0,29260149 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,26435909 0,29246075 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,26435909 0,29232014 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,26435909 0,29217967 ! feeding behavior GO:0007631 45 34 0,000 0,26435909 0,29203934 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,26435909 0,29189914 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,26435909 0,29175907 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,26435909 0,29161914 ! aerobic respiration GO:0009060 47 34 0,000 0,26435909 0,29147934 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,26435909 0,29133967 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,27097851 0,29849165 ! Notch signaling pathway GO:0007219 56 35 0,000 0,27097851 0,29834876 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,27097851 0,29820601 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,27097851 0,2980634 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,27097851 0,29792092 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,27097851 0,29777858 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,27097851 0,29763637 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,27097851 0,2974943 ! pigment metabolic process GO:0042440 61 35 0,000 0,27097851 0,29735237 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,27753874 0,30440586 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,27753874 0,30426077 ! organic ether metabolic process GO:0018904 46 36 0,000 0,27753874 0,30411582 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,27753874 0,303971 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,27753874 0,30382632 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,27753874 0,30368178 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,28404031 0,31064799 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,28404031 0,31050034 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,28404031 0,31035283 ! learning GO:0007612 67 37 0,000 0,28404031 0,31020547 ! ion transmembrane transport GO:0034220 56 37 0,000 0,28404031 0,31005824 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,28404031 0,30991115 ! regulation of protein secretion GO:0050708 51 37 0,000 0,28404031 0,30976421 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,28404031 0,3096174 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,29048374 0,31649105 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,29048374 0,3163412 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,29048374 0,31619148 ! phagocytosis GO:0006909 60 38 0,000 0,29048374 0,31604191 ! pigmentation GO:0043473 74 38 0,000 0,29048374 0,31589249 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,29686955 0,32268429 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,29686955 0,32253187 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,29686955 0,32237959 ! male sex differentiation GO:0046661 53 39 0,000 0,29686955 0,32222745 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,29686955 0,32207546 ! chromatin remodeling GO:0006338 68 39 0,000 0,29686955 0,32192361 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,29686955 0,3217719 ! cell growth GO:0016049 61 39 0,000 0,29686955 0,32162033 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,30319825 0,32832202 ! response to calcium ion GO:0051592 58 40 0,000 0,30319825 0,32816752 ! regulation of tube size GO:0035150 60 40 0,000 0,30319825 0,32801316 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,30319825 0,32785894 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,30319825 0,32770487 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,30319825 0,32755095 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,30319825 0,32739717 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,30947034 0,33401304 ! endosome transport GO:0016197 71 41 0,000 0,30947034 0,33385637 ! striated muscle contraction GO:0006941 62 41 0,000 0,30947034 0,33369985 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,30947034 0,33354348 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,31568634 0,34008364 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,31568634 0,33992443 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,31568634 0,33976536 ! excretion GO:0007588 63 42 0,000 0,31568634 0,33960644 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,31568634 0,33944768 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,31568634 0,33928905 ! leukocyte migration GO:0050900 60 43 0,000 0,32184673 0,34574847 ! neuromuscular process GO:0050905 79 43 0,000 0,32184673 0,34558706 ! tRNA processing GO:0008033 49 43 0,000 0,32184673 0,3454258 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,32184673 0,34526468 ! vesicle organization GO:0016050 79 43 0,000 0,32184673 0,34510372 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,32795202 0,35148632 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,32795202 0,35132261 ! regulation of ion transport GO:0043269 57 44 0,000 0,32795202 0,35115905 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,32795202 0,35099564 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,32795202 0,35083239 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,32795202 0,35066929 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,32795202 0,35050634 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,32795202 0,35034354 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,32795202 0,35018089 ! RNA catabolic process GO:0006401 64 45 0,000 0,33400268 0,35647618 ! positive regulation of defense response GO:0031349 59 45 0,000 0,33400268 0,35631084 ! regulation of translational initiation GO:0006446 64 45 0,000 0,33400268 0,35614565 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,33400268 0,35598062 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,33999922 0,36220389 ! cell redox homeostasis GO:0045454 63 46 0,000 0,33999922 0,3620362 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,33999922 0,36186867 ! regulation of ossification GO:0030278 71 46 0,000 0,33999922 0,3617013 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,33999922 0,36153407 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,3459421 0,36768338 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,3459421 0,36751355 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,3459421 0,36734387 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,3459421 0,36717436 ! chloride transport GO:0006821 67 48 0,000 0,35183181 0,3732533 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,35183181 0,37308122 ! response to temperature stimulus GO:0009266 62 48 0,000 0,35183181 0,37290929 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,35183181 0,37273752 ! gastrulation GO:0007369 73 48 0,000 0,35183181 0,37256591 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,35183181 0,37239446 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,35183181 0,37222317 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,35183181 0,37205203 ! regulation of endocytosis GO:0030100 63 48 0,000 0,35183181 0,37188105 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,35766882 0,37787703 ! sensory perception of smell GO:0007608 61 49 0,000 0,35766882 0,37770353 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,35766882 0,37753019 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,35766882 0,37735701 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,35766882 0,37718399 ! regulation of actin filament length GO:0030832 72 50 0,000 0,3634536 0,38310874 ! positive regulation of growth GO:0045927 67 50 0,000 0,3634536 0,38293324 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,3634536 0,38275791 ! proton transport GO:0015992 75 50 0,000 0,3634536 0,38258273 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,3634536 0,38240772 ! positive regulation of secretion GO:0051047 71 51 0,000 0,3691866 0,38826209 ! hydrogen transport GO:0006818 77 51 0,000 0,3691866 0,38808464 ! adult behavior GO:0030534 80 51 0,000 0,3691866 0,38790735 ! transition metal ion transport GO:0000041 74 52 0,000 0,3748683 0,3936973 ! regulation of cellular component size GO:0032535 74 52 0,000 0,3748683 0,39351762 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,3748683 0,39333809 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,38049915 0,39906432 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,38049915 0,39888243 ! amino acid transport GO:0006865 84 54 0,000 0,3860796 0,4045481 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,3860796 0,40436388 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,3860796 0,40417983 ! detection of external stimulus GO:0009581 66 54 0,000 0,3860796 0,40399594 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,3860796 0,40381222 ! exocytosis GO:0006887 74 55 0,000 0,3916101 0,40941055 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,3916101 0,40922454 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,3916101 0,4090387 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,39709109 0,41457535 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,40252301 0,42005577 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,40252301 0,41986527 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,40252301 0,41967494 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,4079063 0,42509492 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,4132414 0,43045979 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,4132414 0,43026492 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,41852873 0,43557288 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,41852873 0,43537588 ! regulation of heart contraction GO:0008016 91 60 0,000 0,41852873 0,43517905 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,41852873 0,43498241 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,42376871 0,44022946 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,42376871 0,44003071 ! amine catabolic process GO:0009310 90 62 0,000 0,42896177 0,44522205 ! neurotransmitter transport GO:0006836 81 62 0,000 0,42896177 0,44502123 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,42896177 0,44482059 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,42896177 0,44462013 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,43410833 0,44975187 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,43920879 0,45483125 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,43920879 0,45462656 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,43920879 0,45442205 ! defense response to bacterium GO:0042742 73 65 0,000 0,44426357 0,45944524 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,44426357 0,45923875 ! activation of immune response GO:0002253 83 65 0,000 0,44426357 0,45903244 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,44927308 0,46400004 ! antigen processing and presentation GO:0019882 96 66 0,000 0,44927308 0,46379178 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,44927308 0,46358371 ! regulation of immune effector process GO:0002697 101 66 0,000 0,44927308 0,46337582 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,45423772 0,46828631 ! acute inflammatory response GO:0002526 92 68 0,000 0,45915789 0,47314657 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,45915789 0,47293468 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,45915789 0,47272298 ! rhythmic process GO:0048511 105 68 0,000 0,45915789 0,47251147 ! inorganic anion transport GO:0015698 93 68 0,000 0,45915789 0,47230015 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,46403397 0,47710243 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,46403397 0,47688925 ! response to metal ion GO:0010038 103 70 0,000 0,46886638 0,48164032 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,46886638 0,4814253 ! humoral immune response GO:0006959 86 70 0,000 0,46886638 0,48121047 ! amine transport GO:0015837 101 70 0,000 0,46886638 0,48099584 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,47365549 0,48569221 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,47365549 0,48547577 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,47840169 0,490122 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,48310536 0,49472054 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,48776688 0,49927184 ! digestion GO:0007586 97 74 0,000 0,48776688 0,49904975 ! blood coagulation GO:0007596 116 75 0,000 0,49238663 0,50355236 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,49238663 0,50332856 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,49238663 0,50310496 ! amine biosynthetic process GO:0009309 97 76 0,000 0,49696498 0,50755749 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,5015023 0,51196417 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,5015023 0,51173704 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,5015023 0,5115101 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,5015023 0,51128337 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,50599894 0,51563915 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,50599894 0,51541079 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,50599894 0,51518263 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,51045528 0,51948989 ! cellular respiration GO:0045333 107 79 0,000 0,51045528 0,51926013 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,51045528 0,51903057 ! regulation of lyase activity GO:0051339 133 79 0,000 0,51045528 0,51880122 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,51045528 0,51857206 ! chromatin assembly GO:0031497 102 80 0,000 0,51487168 0,52282775 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,51487168 0,52259703 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,51924848 0,52680702 ! hemostasis GO:0007599 125 81 0,000 0,51924848 0,52657474 ! regulation of neurological system process GO:0031644 122 81 0,000 0,51924848 0,52634267 ! vitamin metabolic process GO:0006766 103 81 0,000 0,51924848 0,5261108 ! detection of stimulus GO:0051606 108 82 0,000 0,52358605 0,53027209 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,52788473 0,53439035 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,52788473 0,53415525 ! regulation of defense response GO:0031347 117 84 0,000 0,53214486 0,53822919 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,53214486 0,53799261 ! sterol metabolic process GO:0016125 120 84 0,000 0,53214486 0,53775623 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,5363668 0,54178465 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,54055088 0,5457713 ! nucleosome organization GO:0034728 114 87 0,000 0,54469744 0,54971659 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,54469744 0,54947548 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,54469744 0,54923459 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,54880681 0,55313569 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,54880681 0,55289341 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,55287932 0,55675238 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,55287932 0,55650873 ! ATP metabolic process GO:0046034 137 91 0,000 0,5609151 0,56435027 ! response to virus GO:0009615 122 91 0,000 0,5609151 0,56410351 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,56487901 0,56784166 ! positive regulation of immune response GO:0050778 121 92 0,000 0,56487901 0,56759358 ! sulfur metabolic process GO:0006790 118 92 0,000 0,56487901 0,56734573 ! electron transport chain GO:0022900 123 94 0,000 0,57270046 0,57495027 ! carboxylic acid transport GO:0046942 147 95 0,000 0,57655864 0,57857106 GO:0015849|organic acid transport, ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,58417146 0,5859548 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,58417146 0,58569937 ! calcium ion transport GO:0006816 167 99 0,000 0,59164827 0,59293726 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,59533642 0,5963736 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,59533642 0,59611396 ! divalent metal ion transport GO:0070838 171 100 0,000 0,59533642 0,59585456 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,59533642 0,59559538 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,59533642 0,59533642