pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6581-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! elastic fiber assembly GO:0048251 17 10 7,000 6,741E-17 1,647E-13 ! collagen metabolic process GO:0032963 49 32 8,000 2,184E-13 2,667E-10 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 8,000 5,411E-13 4,407E-10 ! multicellular organismal metabolic process GO:0044236 64 41 8,000 2,603E-12 1,59E-09 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 8,000 7,974E-12 3,896E-09 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 8,000 6,15E-11 2,504E-08 ! aging GO:0007568 112 58 8,000 7,241E-11 2,527E-08 ! extracellular matrix organization GO:0030198 146 68 8,000 3,181E-10 9,715E-08 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 6,000 3,625E-10 9,839E-08 ! interphase of mitotic cell cycle GO:0051329 224 98 9,000 4,475E-10 1,093E-07 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 5,000 5,199E-10 1,155E-07 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 6,000 2,295E-09 4,673E-07 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 4,000 3,387E-09 6,364E-07 GO:0010812|negative regulation of cell-substrate adhesion, ! phospholipid dephosphorylation GO:0046839 12 5 3,000 6,358E-09 1,11E-06 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 1,898E-08 3,092E-06 ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 4,409E-08 6,732E-06 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 8,776E-08 1,261E-05 ! regulation of intracellular protein transport GO:0033157 86 42 5,000 1,944E-07 2,638E-05 ! regulation of cell-matrix adhesion GO:0001952 81 23 4,000 2,326E-07 2,99E-05 GO:0010810|regulation of cell-substrate adhesion, ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 2,608E-07 3,186E-05 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 3,000 2,608E-07 3,034E-05 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 5,000 3,402E-07 3,778E-05 ! positive regulation of cell cycle GO:0045787 96 48 5,000 4,412E-07 4,687E-05 ! JAK-STAT cascade GO:0007259 82 48 5,000 4,412E-07 4,491E-05 ! meiosis GO:0007126 143 81 6,000 6,196E-07 6,055E-05 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 144 82 6,000 6,74E-07 6,333E-05 ! negative regulation of growth GO:0045926 168 85 6,000 8,618E-07 7,797E-05 ! regulation of mRNA stability GO:0043488 32 13 3,000 8,754E-07 7,638E-05 ! regulation of angiogenesis GO:0045765 125 54 5,000 9,012E-07 7,591E-05 ! embryonic skeletal system development GO:0048706 101 54 5,000 9,012E-07 7,338E-05 ! regulation of RNA stability GO:0043487 33 14 3,000 1,22E-06 9,613E-05 ! regulation of intracellular transport GO:0032386 108 57 5,000 1,247E-06 9,522E-05 ! regulation of cell cycle process GO:0010564 161 90 6,000 1,272E-06 9,414E-05 ! skeletal system morphogenesis GO:0048705 118 63 5,000 2,266E-06 1,628E-04 ! negative regulation of cell adhesion GO:0007162 94 37 4,000 2,813E-06 1,963E-04 ! endothelial cell migration GO:0043542 31 17 3,000 2,859E-06 1,94E-04 ! cardiac muscle tissue development GO:0048738 34 17 3,000 2,859E-06 1,888E-04 ! embryonic skeletal system morphogenesis GO:0048704 68 38 4,000 3,223E-06 2,072E-04 ! regulation of protein stability GO:0031647 77 38 4,000 3,223E-06 2,019E-04 ! negative regulation of cell growth GO:0030308 142 67 5,000 3,263E-06 1,993E-04 ! negative regulation of cell size GO:0045792 144 69 5,000 3,88E-06 2,312E-04 ! inositol metabolic process GO:0006020 33 19 3,000 4,613E-06 2,683E-04 ! dorsal/ventral pattern formation GO:0009953 75 42 4,000 5,357E-06 3,043E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 3,000 5,739E-06 3,186E-04 ! double-strand break repair GO:0006302 85 44 4,000 6,772E-06 3,677E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 7,399E-06 3,93E-04 ! cranial nerve morphogenesis GO:0021602 12 7 2,000 7,399E-06 3,846E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 7,582E-06 3,859E-04 ! negative regulation of cell migration GO:0030336 122 46 4,000 8,465E-06 4,22E-04 ! positive regulation of intracellular transport GO:0032388 42 22 3,000 8,583E-06 4,194E-04 ! male meiosis GO:0007140 9 8 2,000 1,179E-05 5,646E-04 ! ER overload response GO:0006983 13 8 2,000 1,179E-05 5,537E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,179E-05 5,433E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,179E-05 5,332E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 1,179E-05 5,235E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 1,235E-05 5,388E-04 ! regulation of oxidoreductase activity GO:0051341 48 24 3,000 1,235E-05 5,294E-04 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 3,000 1,463E-05 6,164E-04 ! negative regulation of DNA replication GO:0008156 45 25 3,000 1,463E-05 6,06E-04 ! regulation of protein transport GO:0051223 165 87 5,000 1,494E-05 6,082E-04 GO:0070201|regulation of establishment of protein localization, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 1,721E-05 6,894E-04 GO:0045936|negative regulation of phosphate metabolic process, ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 1,76E-05 6,935E-04 ! response to unfolded protein GO:0006986 139 90 5,000 1,814E-05 7,036E-04 ! gland development GO:0048732 220 91 5,000 1,933E-05 7,378E-04 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 2,011E-05 7,559E-04 ! response to UV GO:0009411 120 55 4,000 2,056E-05 7,61E-04 ! negative regulation of cell motion GO:0051271 142 55 4,000 2,056E-05 7,496E-04 ! regulation of cell adhesion GO:0030155 241 92 5,000 2,057E-05 7,392E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 2,503E-05 8,863E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 2,000 2,503E-05 8,736E-04 ! response to protein stimulus GO:0051789 158 96 5,000 2,622E-05 9,022E-04 ! positive regulation of cell migration GO:0030335 137 58 4,000 2,668E-05 9,054E-04 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 2,781E-05 9,306E-04 ! regulation of protein localization GO:0032880 188 97 5,000 2,781E-05 9,181E-04 ! forebrain development GO:0030900 210 98 5,000 2,947E-05 9,601E-04 ! negative regulation of protein kinase cascade GO:0010741 72 30 3,000 3,096E-05 9,953E-04 ! lipid modification GO:0030258 112 60 4,000 3,15E-05 9,993E-04 ! kidney development GO:0001822 133 60 4,000 3,15E-05 9,865E-04 ! thyroid gland development GO:0030878 26 11 2,000 3,427E-05 1,06E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 2,000 3,427E-05 1,046E-03 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 2,000 3,427E-05 1,033E-03 ! embryonic gut development GO:0048566 19 11 2,000 3,427E-05 1,021E-03 ! metanephros development GO:0001656 81 32 3,000 4,025E-05 1,185E-03 ! regulation of protein import into nucleus GO:0042306 69 32 3,000 4,025E-05 1,171E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 4,548E-05 1,307E-03 ! cranial nerve development GO:0021545 23 12 2,000 4,548E-05 1,292E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 4,548E-05 1,277E-03 GO:0042130|negative regulation of T cell proliferation, ! positive regulation of gene-specific transcription GO:0043193 70 33 3,000 4,559E-05 1,266E-03 ! positive regulation of cell motion GO:0051272 157 65 4,000 4,649E-05 1,276E-03 ! negative regulation of DNA metabolic process GO:0051053 65 35 3,000 5,778E-05 1,568E-03 ! double-strand break repair via homologous recombination GO:0000724 19 13 2,000 5,887E-05 1,58E-03 GO:0000725|recombinational repair, ! response to X-ray GO:0010165 28 13 2,000 5,887E-05 1,563E-03 ! regulation of monooxygenase activity GO:0032768 35 13 2,000 5,887E-05 1,546E-03 ! urogenital system development GO:0001655 149 69 4,000 6,203E-05 1,612E-03 ! embryonic organ development GO:0048568 67 36 3,000 6,47E-05 1,664E-03 ! regulation of S phase GO:0033261 26 14 2,000 7,459E-05 1,898E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 2,000 7,459E-05 1,879E-03 GO:0060675|ureteric bud morphogenesis, ! response to gamma radiation GO:0010332 30 14 2,000 7,459E-05 1,859E-03 ! respiratory tube development GO:0030323 171 72 4,000 7,61E-05 1,878E-03 ! meiosis I GO:0007127 74 38 3,000 8,032E-05 1,962E-03 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 3,000 8,032E-05 1,943E-03 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 8,032E-05 1,924E-03 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 2,000 9,282E-05 2,202E-03 ! positive regulation of oxidoreductase activity GO:0051353 22 15 2,000 9,282E-05 2,18E-03 ! mammary gland development GO:0030879 93 40 3,000 9,851E-05 2,292E-03 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 1,049E-04 2,417E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 2,000 1,137E-04 2,597E-03 ! heterophilic cell adhesion GO:0007157 43 16 2,000 1,137E-04 2,573E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 1,137E-04 2,549E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,137E-04 2,526E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 4,000 1,185E-04 2,608E-03 ! ear morphogenesis GO:0042471 64 42 3,000 1,195E-04 2,607E-03 ! protein import into nucleus GO:0006606 174 82 4,000 1,414E-04 3,056E-03 ! nuclear import GO:0051170 177 83 4,000 1,497E-04 3,208E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 1,569E-04 3,332E-03 ! polyol metabolic process GO:0019751 77 45 3,000 1,569E-04 3,304E-03 ! regulation of ligase activity GO:0051340 147 84 4,000 1,584E-04 3,307E-03 ! response to retinoic acid GO:0032526 31 18 2,000 1,643E-04 3,401E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 1,643E-04 3,372E-03 ! nerve development GO:0021675 34 18 2,000 1,643E-04 3,344E-03 ! regulation of gene-specific transcription GO:0032583 102 46 3,000 1,71E-04 3,452E-03 ! positive regulation of protein transport GO:0051222 80 46 3,000 1,71E-04 3,424E-03 ! response to insulin stimulus GO:0032868 98 47 3,000 1,86E-04 3,695E-03 ! response to vitamin A GO:0033189 32 19 2,000 1,942E-04 3,826E-03 ! protein localization in nucleus GO:0034504 192 89 4,000 2,078E-04 4,062E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 2,189E-04 4,244E-03 ! response to vitamin GO:0033273 36 20 2,000 2,275E-04 4,375E-03 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 2,275E-04 4,341E-03 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 2,000 2,275E-04 4,308E-03 ! negative regulation of T cell activation GO:0050868 41 20 2,000 2,275E-04 4,274E-03 ! negative regulation of angiogenesis GO:0016525 49 21 2,000 2,642E-04 4,927E-03 ! negative regulation of intracellular transport GO:0032387 44 21 2,000 2,642E-04 4,89E-03 ! DNA-dependent DNA replication GO:0006261 82 52 3,000 2,758E-04 5,066E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 2,969E-04 5,413E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! reciprocal meiotic recombination GO:0007131 44 22 2,000 3,045E-04 5,511E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 2,000 3,045E-04 5,471E-03 ! ureteric bud development GO:0001657 50 22 2,000 3,045E-04 5,431E-03 ! cell aging GO:0007569 48 22 2,000 3,045E-04 5,391E-03 ! gut development GO:0048565 44 22 2,000 3,045E-04 5,353E-03 ! epithelial tube morphogenesis GO:0060562 114 54 3,000 3,192E-04 5,569E-03 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 2,000 3,487E-04 6,041E-03 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 2,000 3,487E-04 5,999E-03 ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 3,565E-04 6,091E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,565E-04 6,048E-03 ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 3,565E-04 6,007E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 3,565E-04 5,966E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 3,565E-04 5,925E-03 ! microvillus organization GO:0032528 8 5 1,000 3,565E-04 5,885E-03 GO:0030033|microvillus assembly, ! muscle cell migration GO:0014812 8 5 1,000 3,565E-04 5,845E-03 ! mRNA transcription GO:0009299 10 5 1,000 3,565E-04 5,807E-03 ! nerve growth factor processing GO:0032455 9 5 1,000 3,565E-04 5,768E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 3,565E-04 5,73E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 3,565E-04 5,693E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 3,565E-04 5,656E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 3,565E-04 5,619E-03 ! mitotic recombination GO:0006312 9 5 1,000 3,565E-04 5,583E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 3,565E-04 5,548E-03 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 1,000 3,565E-04 5,513E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 3,565E-04 5,478E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 3,565E-04 5,444E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 3,565E-04 5,41E-03 ! stem cell division GO:0017145 11 5 1,000 3,565E-04 5,376E-03 GO:0048103|somatic stem cell division, ! regulation of DNA replication GO:0006275 105 56 3,000 3,672E-04 5,504E-03 ! nucleotide-excision repair GO:0006289 91 57 3,000 3,931E-04 5,855E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 3,967E-04 5,874E-03 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 4,488E-04 6,605E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 5,051E-04 7,389E-03 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 5,051E-04 7,345E-03 ! negative regulation of cell development GO:0010721 83 26 2,000 5,051E-04 7,302E-03 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 2,000 5,051E-04 7,259E-03 GO:0045840|positive regulation of mitosis, ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 5,327E-04 7,61E-03 ! forebrain regionalization GO:0021871 9 6 1,000 5,327E-04 7,566E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 5,327E-04 7,522E-03 ! toxin metabolic process GO:0009404 11 6 1,000 5,327E-04 7,479E-03 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 1,000 5,327E-04 7,436E-03 ! positive regulation of neuroblast proliferation GO:0002052 13 6 1,000 5,327E-04 7,394E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 5,327E-04 7,352E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 5,327E-04 7,311E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of spindle localization GO:0051293 16 6 1,000 5,327E-04 7,27E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 5,327E-04 7,229E-03 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 1,000 5,327E-04 7,189E-03 ! response to UV-C GO:0010225 14 6 1,000 5,327E-04 7,15E-03 ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 5,327E-04 7,111E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 5,327E-04 7,072E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 5,327E-04 7,034E-03 ! ectodermal gut morphogenesis GO:0048567 16 6 1,000 5,327E-04 6,996E-03 GO:0007439|ectodermal gut development, ! negative regulation of B cell activation GO:0050869 14 6 1,000 5,327E-04 6,959E-03 ! DNA damage response, signal transduction GO:0042770 136 62 3,000 5,422E-04 7,046E-03 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 5,658E-04 7,313E-03 ! cellular response to oxidative stress GO:0034599 43 27 2,000 5,658E-04 7,274E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 5,658E-04 7,236E-03 ! regulation of mitosis GO:0007088 112 63 3,000 5,763E-04 7,333E-03 GO:0051783|regulation of nuclear division, ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 6,118E-04 7,745E-03 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 6,118E-04 7,705E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 6,308E-04 7,903E-03 ! ear development GO:0043583 114 66 3,000 6,875E-04 8,57E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 7,005E-04 8,687E-03 ! negative regulation of neuron differentiation GO:0045665 46 29 2,000 7,005E-04 8,643E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 7,428E-04 9,118E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 7,428E-04 9,073E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 7,428E-04 9,028E-03 ! mRNA stabilization GO:0048255 18 7 1,000 7,428E-04 8,983E-03 GO:0043489|RNA stabilization, ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 1,000 7,428E-04 8,939E-03 ! spinal cord patterning GO:0021511 14 7 1,000 7,428E-04 8,895E-03 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 7,428E-04 8,852E-03 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 7,428E-04 8,809E-03 ! centrosome duplication GO:0051298 14 7 1,000 7,428E-04 8,766E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 7,428E-04 8,724E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 7,428E-04 8,682E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 7,428E-04 8,641E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 7,428E-04 8,6E-03 ! embryonic heart tube development GO:0035050 14 7 1,000 7,428E-04 8,559E-03 ! regulation of B cell activation GO:0050864 55 30 2,000 7,749E-04 8,888E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 8,132E-04 9,283E-03 ! lung development GO:0030324 165 69 3,000 8,132E-04 9,24E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 3,000 8,132E-04 9,197E-03 ! cell junction assembly GO:0034329 85 31 2,000 8,542E-04 9,616E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 8,542E-04 9,572E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 8,542E-04 9,528E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 8,585E-04 9,533E-03 ! cell cycle checkpoint GO:0000075 145 71 3,000 9,055E-04 0,0100092 ! spindle organization GO:0007051 50 32 2,000 9,383E-04 0,01032607 ! positive regulation of catabolic process GO:0009896 72 32 2,000 9,383E-04 0,01027977 ! appendage morphogenesis GO:0035107 150 72 3,000 9,542E-04 0,01040721 GO:0035108|limb morphogenesis, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 3,000 9,542E-04 0,01036096 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 3,000 9,542E-04 0,01031511 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 9,864E-04 0,01061594 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 9,864E-04 0,01056938 ! signal peptide processing GO:0006465 12 8 1,000 9,864E-04 0,01052323 ! T-helper 1 type immune response GO:0042088 12 8 1,000 9,864E-04 0,01047747 ! hemoglobin metabolic process GO:0020027 14 8 1,000 9,864E-04 0,01043212 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 9,864E-04 0,01038715 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 9,864E-04 0,01034257 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 9,864E-04 0,01029837 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 9,864E-04 0,01025455 ! regulation of vascular permeability GO:0043114 12 8 1,000 9,864E-04 0,0102111 ! gas homeostasis GO:0033483 14 8 1,000 9,864E-04 0,01016801 ! response to tumor cell GO:0002347 16 8 1,000 9,864E-04 0,01012529 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 9,864E-04 0,01008292 ! blastocyst growth GO:0001832 19 8 1,000 9,864E-04 0,01004091 ! appendage development GO:0048736 151 73 3,000 1,005E-03 0,01018607 GO:0060173|limb development, ! response to ionizing radiation GO:0010212 74 33 2,000 1,028E-03 0,01037393 ! negative regulation of protein transport GO:0051224 74 33 2,000 1,028E-03 0,01033124 ! regulation of caspase activity GO:0043281 136 74 3,000 1,057E-03 0,0105861 ! negative regulation of transferase activity GO:0051348 155 74 3,000 1,057E-03 0,01054289 ! respiratory system development GO:0060541 175 74 3,000 1,057E-03 0,01050003 ! inner ear morphogenesis GO:0042472 51 34 2,000 1,122E-03 0,01109832 ! cell fate specification GO:0001708 56 34 2,000 1,122E-03 0,01105357 ! cell-matrix adhesion GO:0007160 181 76 3,000 1,168E-03 0,01145903 ! telencephalon development GO:0021537 81 35 2,000 1,222E-03 0,01194018 ! regulation of endopeptidase activity GO:0052548 141 77 3,000 1,226E-03 0,01193467 ! positive regulation of ligase activity GO:0051351 130 77 3,000 1,226E-03 0,01188731 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,263E-03 0,01219784 ! induction of positive chemotaxis GO:0050930 17 9 1,000 1,263E-03 0,01214982 ! regulation of glycolysis GO:0006110 20 9 1,000 1,263E-03 0,01210217 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 1,263E-03 0,0120549 ! microtubule bundle formation GO:0001578 22 9 1,000 1,263E-03 0,01200799 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,263E-03 0,01196145 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 1,263E-03 0,01191526 ! S phase GO:0051320 10 9 1,000 1,263E-03 0,01186944 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 16 9 1,000 1,263E-03 0,01182396 ! negative regulation of DNA binding GO:0043392 67 36 2,000 1,327E-03 0,01237421 ! protein oligomerization GO:0051259 149 79 3,000 1,349E-03 0,01252844 ! cell junction organization GO:0034330 96 37 2,000 1,438E-03 0,01330509 ! tissue remodeling GO:0048771 78 37 2,000 1,438E-03 0,01325488 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 1,438E-03 0,01320505 ! negative regulation of cell activation GO:0050866 69 37 2,000 1,438E-03 0,01315559 ! response to hypoxia GO:0001666 178 81 3,000 1,48E-03 0,01348746 ! regulation of peptidase activity GO:0052547 150 82 3,000 1,548E-03 0,01406058 ! cell-substrate adhesion GO:0031589 189 82 3,000 1,548E-03 0,0140085 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,573E-03 0,01417815 ! smoothened signaling pathway GO:0007224 18 10 1,000 1,573E-03 0,01412602 ! lung alveolus development GO:0048286 26 10 1,000 1,573E-03 0,01407428 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 1,573E-03 0,01402291 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 1,573E-03 0,01397192 ! multicellular organism growth GO:0035264 19 10 1,000 1,573E-03 0,0139213 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 1,573E-03 0,01387104 ! motor axon guidance GO:0008045 22 10 1,000 1,573E-03 0,01382115 ! regulation of bone resorption GO:0045124 25 10 1,000 1,573E-03 0,01377161 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,573E-03 0,01372242 GO:0045685|regulation of glial cell differentiation, ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 1,573E-03 0,01367359 ! induction of an organ GO:0001759 17 10 1,000 1,573E-03 0,0136251 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,573E-03 0,01357696 GO:0043470|regulation of carbohydrate catabolic process, ! response to oxygen levels GO:0070482 183 83 3,000 1,619E-03 0,01392707 ! negative regulation of binding GO:0051100 71 39 2,000 1,676E-03 0,01436865 ! response to nutrient GO:0007584 135 84 3,000 1,692E-03 0,01445351 ! regulation of neuron differentiation GO:0045664 187 85 3,000 1,767E-03 0,01504402 ! cellular response to hormone stimulus GO:0032870 182 85 3,000 1,767E-03 0,01499178 ! nucleus organization GO:0006997 73 40 2,000 1,804E-03 0,01525116 ! negative regulation of muscle development GO:0048635 27 11 1,000 1,915E-03 0,01612936 ! neuron fate specification GO:0048665 18 11 1,000 1,915E-03 0,01607394 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 1,915E-03 0,01601889 ! blood vessel remodeling GO:0001974 30 11 1,000 1,915E-03 0,01596422 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,915E-03 0,01590992 ! telomere maintenance via telomerase GO:0007004 24 11 1,000 1,915E-03 0,01585599 GO:0010833|telomere maintenance via telomere lengthening, ! regulation of intracellular pH GO:0051453 21 11 1,000 1,915E-03 0,01580242 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 1,915E-03 0,01574921 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 1,000 1,915E-03 0,01569636 ! DNA methylation GO:0006306 19 11 1,000 1,915E-03 0,01564387 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 25 11 1,000 1,915E-03 0,01559172 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 1,915E-03 0,01553992 ! thymus development GO:0048538 29 11 1,000 1,915E-03 0,01548846 ! oocyte development GO:0048599 20 11 1,000 1,915E-03 0,01543735 ! regulation of T cell differentiation GO:0045580 78 42 2,000 2,078E-03 0,01669849 ! cytokinesis GO:0000910 84 42 2,000 2,078E-03 0,01664374 ! regulation of DNA binding GO:0051101 167 89 3,000 2,092E-03 0,01670008 ! tube morphogenesis GO:0035239 194 89 3,000 2,092E-03 0,01664568 ! regulation of T cell proliferation GO:0042129 80 43 2,000 2,224E-03 0,01763972 ! regulation of myeloid cell differentiation GO:0045637 105 43 2,000 2,224E-03 0,01758263 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 2,288E-03 0,01803482 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 2,288E-03 0,01797683 GO:0050927|positive regulation of positive chemotaxis, ! hippocampus development GO:0021766 29 12 1,000 2,288E-03 0,01791921 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 2,288E-03 0,01786196 ! cytokine biosynthetic process GO:0042089 23 12 1,000 2,288E-03 0,01780508 ! regulation of exit from mitosis GO:0007096 19 12 1,000 2,288E-03 0,01774856 ! ventral spinal cord development GO:0021517 25 12 1,000 2,288E-03 0,01769239 ! oligodendrocyte differentiation GO:0048709 17 12 1,000 2,288E-03 0,01763658 ! focal adhesion formation GO:0048041 37 12 1,000 2,288E-03 0,01758112 ! entry into host cell GO:0030260 34 12 1,000 2,288E-03 0,017526 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 2,288E-03 0,01747123 ! mRNA polyadenylation GO:0006378 24 12 1,000 2,288E-03 0,01741681 ! autonomic nervous system development GO:0048483 24 12 1,000 2,288E-03 0,01736272 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 2,288E-03 0,01730896 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,288E-03 0,01725554 ! regulation of leukocyte migration GO:0002685 29 12 1,000 2,288E-03 0,01720245 ! oocyte differentiation GO:0009994 21 12 1,000 2,288E-03 0,01714968 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 2,288E-03 0,01709723 ! developmental induction GO:0031128 22 12 1,000 2,288E-03 0,01704511 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 1,000 2,288E-03 0,0169933 ! localization within membrane GO:0051668 26 12 1,000 2,288E-03 0,0169418 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 2,455E-03 0,01812076 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 2,535E-03 0,01865111 ! developmental growth GO:0048589 88 45 2,000 2,535E-03 0,0185951 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 2,694E-03 0,01970406 ! cytokine metabolic process GO:0042107 24 13 1,000 2,694E-03 0,01964524 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 2,694E-03 0,01958677 ! digestive tract morphogenesis GO:0048546 31 13 1,000 2,694E-03 0,01952865 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! mRNA 3'-end processing GO:0031124 25 13 1,000 2,694E-03 0,01947087 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 2,694E-03 0,01941344 ! regulation of chemokine production GO:0032642 18 13 1,000 2,694E-03 0,01935634 ! cartilage condensation GO:0001502 22 13 1,000 2,694E-03 0,01929958 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 2,694E-03 0,01924314 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neural tube development GO:0021915 91 47 2,000 2,871E-03 0,02044814 ! non-recombinational repair GO:0000726 29 14 1,000 3,13E-03 0,02223152 GO:0006303|double-strand break repair via nonhomologous end joining, ! RNA polyadenylation GO:0043631 32 14 1,000 3,13E-03 0,02216708 ! embryo implantation GO:0007566 30 14 1,000 3,13E-03 0,02210302 ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 3,13E-03 0,02203932 ! RNA-dependent DNA replication GO:0006278 28 14 1,000 3,13E-03 0,02197599 ! regulation of cellular pH GO:0030641 27 14 1,000 3,13E-03 0,02191302 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 3,13E-03 0,02185041 ! skeletal muscle tissue development GO:0007519 223 100 3,000 3,192E-03 0,02221348 GO:0060538|skeletal muscle organ development, ! response to calcium ion GO:0051592 94 49 2,000 3,233E-03 0,02244114 ! regulation of lymphocyte differentiation GO:0045619 92 49 2,000 3,233E-03 0,02237757 ! protein homooligomerization GO:0051260 84 49 2,000 3,233E-03 0,02231435 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 3,425E-03 0,02356778 ! endocrine system development GO:0035270 109 50 2,000 3,425E-03 0,02350158 ! activation of caspase activity GO:0006919 95 50 2,000 3,425E-03 0,02343574 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 3,598E-03 0,02455117 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3,598E-03 0,02448278 ! regulation of mRNA processing GO:0050684 26 15 1,000 3,598E-03 0,02441477 ! G1/S transition checkpoint GO:0031575 37 15 1,000 3,598E-03 0,02434714 ! muscle maintenance GO:0046716 26 15 1,000 3,598E-03 0,02427988 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 3,598E-03 0,024213 ! viral infectious cycle GO:0019058 104 51 2,000 3,623E-03 0,02431433 ! negative regulation of immune system process GO:0002683 101 51 2,000 3,623E-03 0,02424772 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 3,828E-03 0,02554926 ! inner ear development GO:0048839 89 53 2,000 4,04E-03 0,02688983 ! cartilage development GO:0051216 99 53 2,000 4,04E-03 0,02681676 ! synapse organization GO:0050808 102 53 2,000 4,04E-03 0,02674409 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 4,095E-03 0,02704119 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 1,000 4,095E-03 0,0269683 ! neuron recognition GO:0008038 40 16 1,000 4,095E-03 0,02689581 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 4,095E-03 0,0268237 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 4,095E-03 0,02675198 ! peptide hormone processing GO:0016486 27 16 1,000 4,095E-03 0,02668064 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 4,623E-03 0,03003852 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 4,623E-03 0,02995884 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 4,623E-03 0,02987959 GO:0031114|regulation of microtubule depolymerization, ! DNA unwinding during replication GO:0006268 26 17 1,000 4,623E-03 0,02980075 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 4,623E-03 0,02972233 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 4,623E-03 0,02964432 ! RNA 3'-end processing GO:0031123 37 17 1,000 4,623E-03 0,02956671 ! skeletal muscle fiber development GO:0048741 130 56 2,000 4,717E-03 0,03008989 ! positive regulation of caspase activity GO:0043280 108 57 2,000 4,958E-03 0,03153991 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 2,000 4,958E-03 0,03145799 ! limbic system development GO:0021761 40 18 1,000 5,181E-03 0,03278791 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 1,000 5,181E-03 0,03270319 GO:0050886|endocrine process, ! heart looping GO:0001947 34 18 1,000 5,181E-03 0,0326189 ! centrosome cycle GO:0007098 26 18 1,000 5,181E-03 0,03253505 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 5,181E-03 0,03245162 ! neural crest cell migration GO:0001755 41 18 1,000 5,181E-03 0,03236863 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 5,181E-03 0,03228605 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 5,181E-03 0,0322039 ! positive regulation of organelle organization GO:0010638 108 58 2,000 5,205E-03 0,03227398 ! memory GO:0007613 34 19 1,000 5,767E-03 0,03566905 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 5,767E-03 0,03557898 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 5,767E-03 0,03548936 ! neuromuscular junction development GO:0007528 43 19 1,000 5,767E-03 0,03540019 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 5,767E-03 0,03531147 ! peptide biosynthetic process GO:0043043 26 19 1,000 5,767E-03 0,03522319 ! proximal/distal pattern formation GO:0009954 33 19 1,000 5,767E-03 0,03513535 ! embryonic organ morphogenesis GO:0048562 34 19 1,000 5,767E-03 0,03504795 ! viral reproductive process GO:0022415 132 62 2,000 6,269E-03 0,0380013 ! regulation of homeostatic process GO:0032844 148 62 2,000 6,269E-03 0,03790724 ! protein secretion GO:0009306 45 20 1,000 6,383E-03 0,03850125 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 6,383E-03 0,03840642 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 6,383E-03 0,03831206 ! protein amino acid acetylation GO:0006473 41 20 1,000 6,383E-03 0,03821816 ! transcription from RNA polymerase III promoter GO:0006383 46 20 1,000 6,383E-03 0,03812471 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 6,383E-03 0,03803173 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 6,383E-03 0,03793919 ! DNA duplex unwinding GO:0032508 30 20 1,000 6,383E-03 0,03784711 GO:0032392|DNA geometric change, ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 6,383E-03 0,03775547 ! actin filament bundle formation GO:0051017 47 20 1,000 6,383E-03 0,03766427 ! integrin-mediated signaling pathway GO:0007229 160 64 2,000 6,846E-03 0,04029811 ! lipid phosphorylation GO:0046834 43 21 1,000 7,027E-03 0,04126548 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 7,027E-03 0,04116652 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 7,027E-03 0,04106804 ! plasma membrane fusion GO:0045026 33 21 1,000 7,027E-03 0,04097002 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 7,027E-03 0,04087247 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 7,027E-03 0,04077539 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 7,453E-03 0,0431457 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 7,699E-03 0,04446497 ! hindlimb morphogenesis GO:0035137 47 22 1,000 7,699E-03 0,0443601 ! cellular response to starvation GO:0009267 37 22 1,000 7,699E-03 0,04425572 ! central nervous system neuron development GO:0021954 47 22 1,000 7,699E-03 0,04415183 ! apoptotic nuclear changes GO:0030262 34 22 1,000 7,699E-03 0,04404843 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 7,699E-03 0,04394552 ! renal system process GO:0003014 42 22 1,000 7,699E-03 0,04384308 ! positive regulation of locomotion GO:0040017 44 22 1,000 7,699E-03 0,04374112 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 1,000 7,699E-03 0,04363963 ! peptidyl-serine modification GO:0018209 50 22 1,000 7,699E-03 0,04353861 ! positive regulation of B cell activation GO:0050871 42 22 1,000 7,699E-03 0,04343806 ! activation of JUN kinase activity GO:0007257 47 22 1,000 7,699E-03 0,04333798 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 7,699E-03 0,04323835 ! embryonic limb morphogenesis GO:0030326 139 67 2,000 7,768E-03 0,04352665 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ligase activity GO:0051352 116 68 2,000 8,091E-03 0,04523278 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 142 68 2,000 8,091E-03 0,04512951 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 2,000 8,091E-03 0,04502671 ! regulation of chemotaxis GO:0050920 45 23 1,000 8,399E-03 0,04663377 ! axis specification GO:0009798 43 23 1,000 8,399E-03 0,04652802 ! regulation of DNA recombination GO:0000018 51 23 1,000 8,399E-03 0,04642276 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 8,399E-03 0,04631796 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 8,399E-03 0,04621364 ! DNA modification GO:0006304 36 23 1,000 8,399E-03 0,04610979 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 2,000 8,422E-03 0,04613209 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 9,107E-03 0,04977383 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 9,127E-03 0,04976808 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 9,127E-03 0,04965724 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 9,127E-03 0,04954689 ! central nervous system neuron differentiation GO:0021953 51 24 1,000 9,127E-03 0,04943703 ! pallium development GO:0021543 56 24 1,000 9,127E-03 0,04932765 ! oogenesis GO:0048477 44 24 1,000 9,127E-03 0,04921876 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 9,127E-03 0,04911035 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 9,881E-03 0,05305394 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 9,881E-03 0,0529376 ! leukocyte adhesion GO:0007159 55 25 1,000 9,881E-03 0,05282176 ! vasculogenesis GO:0001570 49 25 1,000 9,881E-03 0,05270643 ! regulation of behavior GO:0050795 48 25 1,000 9,881E-03 0,0525916 ! interaction with host GO:0051701 66 25 1,000 9,881E-03 0,05247727 ! liver development GO:0001889 55 25 1,000 9,881E-03 0,05236343 ! protein tetramerization GO:0051262 57 25 1,000 9,881E-03 0,05225009 ! regulation of transcription factor activity GO:0051090 137 75 2,000 0,010573 0,05578798 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,010573 0,05566775 ! axon guidance GO:0007411 162 75 2,000 0,010573 0,05554803 ! myelination GO:0042552 50 26 1,000 0,01066244 0,05589772 ! initiation of viral infection GO:0019059 60 26 1,000 0,01066244 0,05577802 ! microtubule organizing center organization GO:0031023 42 26 1,000 0,01066244 0,05565884 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 1,000 0,01066244 0,05554016 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 0,01066244 0,05542199 ! neural crest cell development GO:0014032 59 26 1,000 0,01066244 0,05530432 GO:0014033|neural crest cell differentiation, ! blastocyst development GO:0001824 50 26 1,000 0,01066244 0,05518715 ! telomere organization GO:0032200 46 26 1,000 0,01066244 0,05507048 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 58 26 1,000 0,01066244 0,0549543 GO:0060606|tube closure, ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 0,01066244 0,0548386 ! regulation of catabolic process GO:0009894 173 77 2,000 0,0113541 0,05827325 ! tube lumen formation GO:0035148 59 27 1,000 0,01147017 0,05874556 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 0,01147017 0,05862266 ! mitochondrial membrane organization GO:0007006 60 27 1,000 0,01147017 0,05850028 ! response to starvation GO:0042594 47 27 1,000 0,01147017 0,0583784 ! response to toxin GO:0009636 49 27 1,000 0,01147017 0,05825703 ! regulation of chromosome organization GO:0033044 49 27 1,000 0,01147017 0,05813617 ! cellular response to nutrient levels GO:0031669 45 27 1,000 0,01147017 0,0580158 ! neuron fate commitment GO:0048663 52 28 1,000 0,01230397 0,06210453 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 0,01230397 0,06197648 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01230397 0,06184896 ! dendrite development GO:0016358 67 28 1,000 0,01230397 0,06172196 ! base-excision repair GO:0006284 41 28 1,000 0,01230397 0,06159548 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 0,01230397 0,06146951 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 0,01230397 0,06134407 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 0,01230397 0,06121913 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01258666 0,06249839 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01316348 0,06522999 ! primary neural tube formation GO:0014020 61 29 1,000 0,01316348 0,06509795 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01316348 0,06496644 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01316348 0,06483546 ! somitogenesis GO:0001756 52 29 1,000 0,01316348 0,064705 ! synaptogenesis GO:0007416 46 29 1,000 0,01316348 0,06457507 ! response to drug GO:0042493 149 83 2,000 0,01389289 0,06801671 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,01404838 0,06864038 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 0,01404838 0,06850337 GO:0048871|multicellular organismal homeostasis, ! response to metal ion GO:0010038 158 84 2,000 0,01434477 0,06980933 ! negative regulation of transport GO:0051051 164 85 2,000 0,01480492 0,07190543 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01495833 0,07250633 ! erythrocyte differentiation GO:0030218 62 31 1,000 0,01495833 0,07236275 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01495833 0,07221974 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01495833 0,0720773 GO:0008366|axon ensheathment, ! eye morphogenesis GO:0048592 65 31 1,000 0,01495833 0,07193541 ! mitochondrion organization GO:0007005 159 87 2,000 0,01575009 0,07559425 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01589299 0,07613054 ! hindbrain development GO:0030902 65 32 1,000 0,01589299 0,07598156 ! regulation of pH GO:0006885 56 33 1,000 0,01685205 0,08040928 ! positive regulation of neurogenesis GO:0050769 72 33 1,000 0,01685205 0,08025254 ! response to inorganic substance GO:0010035 173 90 2,000 0,01723022 0,08189383 ! ossification GO:0001503 205 91 2,000 0,01774028 0,08415438 ! glial cell differentiation GO:0010001 67 34 1,000 0,01783517 0,08444054 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01783517 0,08427721 ! bone development GO:0060348 206 92 2,000 0,0182587 0,08611197 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 2,000 0,01878548 0,0884257 GO:0010498|proteasomal protein catabolic process, ! DNA damage checkpoint GO:0000077 78 35 1,000 0,01884203 0,08852133 ! mRNA export from nucleus GO:0006406 53 35 1,000 0,01884203 0,08835142 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01884203 0,08818217 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01884203 0,08801356 ! placenta development GO:0001890 53 35 1,000 0,01884203 0,08784559 ! regulation of muscle development GO:0048634 82 36 1,000 0,01987233 0,09247256 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01987233 0,09229676 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01987233 0,09212162 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01987233 0,09194715 ! cytokine production GO:0001816 68 36 1,000 0,01987233 0,09177333 ! regulation of T cell activation GO:0050863 175 96 2,000 0,0204161 0,09410667 ! sister chromatid segregation GO:0000819 65 37 1,000 0,02092573 0,09627411 ! odontogenesis GO:0042476 74 37 1,000 0,02092573 0,09609315 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,02092573 0,09591286 ! female gonad development GO:0008585 71 37 1,000 0,02092573 0,09573325 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,02092573 0,09555431 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,02200193 0,10028117 ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,02200193 0,10009443 ! glycogen metabolic process GO:0005977 63 38 1,000 0,02200193 0,09990838 ! neural tube formation GO:0001841 79 38 1,000 0,02200193 0,09972302 ! mRNA transport GO:0051028 185 100 2,000 0,02270769 0,10273125 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,02310061 0,1043157 ! carbohydrate homeostasis GO:0033500 59 39 1,000 0,02310061 0,10412324 GO:0042593|glucose homeostasis, ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,02310061 0,10393148 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,02310061 0,10374043 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 0,02310061 0,10355008 GO:0006073|cellular glucan metabolic process, ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,02422148 0,10837559 GO:0046660|female sex differentiation, ! mismatch repair GO:0006298 58 40 1,000 0,02422148 0,10817746 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,02422148 0,10798005 ! RNA export from nucleus GO:0006405 61 41 1,000 0,02536422 0,11286846 ! gliogenesis GO:0042063 91 41 1,000 0,02536422 0,11266325 ! mesenchymal cell development GO:0014031 94 41 1,000 0,02536422 0,11245878 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,02536422 0,11225505 ! maintenance of protein location GO:0045185 95 41 1,000 0,02536422 0,11205206 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,02536422 0,1118498 ! T cell differentiation GO:0030217 93 42 1,000 0,02652853 0,11677335 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02771413 0,12177268 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,02771413 0,12155405 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 1,000 0,02771413 0,12133621 ! glucose transport GO:0015758 66 43 1,000 0,02771413 0,12111915 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,02771413 0,12090287 ! segmentation GO:0035282 78 43 1,000 0,02771413 0,12068736 ! neuron migration GO:0001764 85 43 1,000 0,02771413 0,12047261 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,0289207 0,12549425 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,0289207 0,12527174 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,0289207 0,12505002 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 0,0289207 0,12482908 ! hexose transport GO:0008645 68 44 1,000 0,0289207 0,12460892 GO:0015749|monosaccharide transport, ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02974487 0,12793438 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02974487 0,12770954 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02974487 0,12748549 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02974487 0,12726222 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02974487 0,12703973 ! neuron fate determination GO:0048664 7 5 0,000 0,02974487 0,12681802 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02974487 0,12659709 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02974487 0,12637692 ! polyol transport GO:0015791 12 5 0,000 0,02974487 0,12615751 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02974487 0,12593887 ! response to superoxide GO:0000303 10 5 0,000 0,02974487 0,12572098 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02974487 0,12550385 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02974487 0,12528746 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02974487 0,12507182 ! female meiosis GO:0007143 10 5 0,000 0,02974487 0,12485692 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02974487 0,12464276 ! hypothalamus development GO:0021854 9 5 0,000 0,02974487 0,12442933 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02974487 0,12421663 ! cobalt ion transport GO:0006824 11 5 0,000 0,02974487 0,12400465 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02974487 0,1237934 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02974487 0,12358287 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02974487 0,12337305 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02974487 0,12316394 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02974487 0,12295555 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02974487 0,12274785 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02974487 0,12254086 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02974487 0,12233456 ! transposition GO:0032196 9 5 0,000 0,02974487 0,12212895 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02974487 0,12192404 ! negative chemotaxis GO:0050919 16 5 0,000 0,02974487 0,12171981 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02974487 0,12151627 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02974487 0,1213134 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02974487 0,12111121 ! behavioral response to pain GO:0048266 10 5 0,000 0,02974487 0,1209097 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02974487 0,12070885 ! Notch receptor processing GO:0007220 11 5 0,000 0,02974487 0,12050867 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02974487 0,12030915 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02974487 0,12011029 ! micturition GO:0060073 9 5 0,000 0,02974487 0,11991209 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02974487 0,11971454 ! copulation GO:0007620 9 5 0,000 0,02974487 0,11951764 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02974487 0,11932139 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02974487 0,11912578 ! bioluminescence GO:0008218 9 5 0,000 0,02974487 0,11893081 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02974487 0,11873648 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02974487 0,11854279 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02974487 0,11834972 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02974487 0,11815728 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02974487 0,11796547 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02974487 0,11777427 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02974487 0,1175837 ! grooming behavior GO:0007625 6 5 0,000 0,02974487 0,11739374 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02974487 0,1172044 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02974487 0,11701566 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02974487 0,11682754 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02974487 0,11664001 ! response to protozoan GO:0001562 13 5 0,000 0,02974487 0,11645309 ! lymph vessel development GO:0001945 10 5 0,000 0,02974487 0,11626676 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02974487 0,11608103 ! endochondral ossification GO:0001958 17 5 0,000 0,02974487 0,1158959 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02974487 0,11571135 ! single strand break repair GO:0000012 8 5 0,000 0,02974487 0,11552739 ! parathyroid gland development GO:0060017 14 5 0,000 0,02974487 0,11534401 ! anagen GO:0042640 7 5 0,000 0,02974487 0,11516122 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02974487 0,114979 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02974487 0,11479736 ! cytokine secretion GO:0050663 15 5 0,000 0,02974487 0,11461629 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02974487 0,11443579 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02974487 0,11425586 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02974487 0,11407649 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02974487 0,11389769 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02974487 0,11371945 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02974487 0,11354176 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02974487 0,11336463 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02974487 0,11318805 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02974487 0,11301202 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02974487 0,11283653 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02974487 0,11266159 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02974487 0,11248719 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02974487 0,11231333 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02974487 0,11214001 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02974487 0,11196722 ! valine metabolic process GO:0006573 12 5 0,000 0,02974487 0,11179496 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02974487 0,11162324 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02974487 0,11145204 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02974487 0,11128136 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02974487 0,1111112 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02974487 0,11094157 ! polyol catabolic process GO:0046174 9 5 0,000 0,02974487 0,11077245 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02974487 0,11060385 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02974487 0,11043576 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02974487 0,11026817 ! mitochondrial fission GO:0000266 8 5 0,000 0,02974487 0,1101011 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02974487 0,10993453 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02974487 0,10976847 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02974487 0,10960291 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02974487 0,10943784 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02974487 0,10927327 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02974487 0,1091092 ! monocyte activation GO:0042117 10 5 0,000 0,02974487 0,10894562 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02974487 0,10878253 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02974487 0,10861992 ! response to food GO:0032094 6 5 0,000 0,02974487 0,1084578 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02974487 0,10829617 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02974487 0,10813501 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02974487 0,10797433 ! forebrain neuron development GO:0021884 13 5 0,000 0,02974487 0,10781414 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02974487 0,10765441 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02974487 0,10749516 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02974487 0,10733638 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02974487 0,10717806 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02974487 0,10702022 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02974487 0,10686283 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02974487 0,10670591 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02974487 0,10654945 ! lipid glycosylation GO:0030259 7 5 0,000 0,02974487 0,10639345 ! nucleobase transport GO:0015851 6 5 0,000 0,02974487 0,10623791 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02974487 0,10608281 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02974487 0,10592817 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02974487 0,10577398 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02974487 0,10562024 ! basic amino acid transport GO:0015802 12 5 0,000 0,02974487 0,10546695 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02974487 0,1053141 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02974487 0,10516169 ! actin nucleation GO:0045010 11 5 0,000 0,02974487 0,10500972 ! depurination GO:0045007 5 5 0,000 0,02974487 0,10485819 ! depyrimidination GO:0045008 10 5 0,000 0,02974487 0,1047071 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02974487 0,10455644 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02974487 0,10440622 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02974487 0,10425642 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02974487 0,10410706 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02974487 0,10395812 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02974487 0,10380961 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02974487 0,10366152 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02974487 0,10351386 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02974487 0,10336661 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02974487 0,10321978 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02974487 0,10307337 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02974487 0,10292738 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02974487 0,10278179 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02974487 0,10263662 ! response to arsenic GO:0046685 11 5 0,000 0,02974487 0,10249186 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02974487 0,1023475 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02974487 0,10220355 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02974487 0,10206001 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02974487 0,10191687 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02974487 0,10177413 ! response to mercury ion GO:0046689 8 5 0,000 0,02974487 0,10163179 ! response to cadmium ion GO:0046686 7 5 0,000 0,02974487 0,10148984 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02974487 0,10134829 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02974487 0,10120714 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02974487 0,10106638 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02974487 0,10092601 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02974487 0,10078603 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02974487 0,10064644 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02974487 0,10050723 ! decidualization GO:0046697 11 5 0,000 0,02974487 0,10036841 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02974487 0,10022997 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02974487 0,10009191 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02974487 0,09995423 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02974487 0,09981693 ! embryonic cleavage GO:0040016 6 5 0,000 0,02974487 0,09968001 ! peroxisome fission GO:0016559 5 5 0,000 0,02974487 0,09954346 ! histone demethylation GO:0016577 13 5 0,000 0,02974487 0,09940729 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02974487 0,09927149 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02974487 0,09913605 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02974487 0,09900099 ! metaphase plate congression GO:0051310 7 5 0,000 0,02974487 0,0988663 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02974487 0,09873197 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02974487 0,098598 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02974487 0,0984644 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02974487 0,09833116 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02974487 0,09819828 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02974487 0,09806576 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02974487 0,09793359 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02974487 0,09780179 ! B cell homeostasis GO:0001782 13 5 0,000 0,02974487 0,09767033 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02974487 0,09753923 ! metaphase GO:0051323 11 5 0,000 0,02974487 0,09740848 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02974487 0,09727808 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02974487 0,09714803 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02974487 0,09701833 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02974487 0,09688897 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02974487 0,09675996 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02974487 0,09663129 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02974487 0,09650296 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02974487 0,09637497 ! response to redox state GO:0051775 6 5 0,000 0,02974487 0,09624732 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02974487 0,09612001 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02974487 0,09599303 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02974487 0,09586639 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02974487 0,09574009 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02974487 0,09561411 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02974487 0,09548847 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02974487 0,09536316 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02974487 0,09523817 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02974487 0,09511352 ! striatum development GO:0021756 14 5 0,000 0,02974487 0,09498919 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02974487 0,09486518 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02974487 0,0947415 ! glial cell migration GO:0008347 10 5 0,000 0,02974487 0,09461813 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02974487 0,09449509 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02974487 0,09437237 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02974487 0,09424997 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02974487 0,09412789 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02974487 0,09400612 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02974487 0,09388466 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02974487 0,09376352 ! neuroprotection GO:0043526 8 5 0,000 0,02974487 0,09364269 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02974487 0,09352217 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02974487 0,09340196 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02974487 0,09328206 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02974487 0,09316247 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02974487 0,09304318 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02974487 0,0929242 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02974487 0,09280553 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02974487 0,09268715 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02974487 0,09256908 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02974487 0,09245131 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02974487 0,09233383 ! spindle assembly GO:0051225 6 5 0,000 0,02974487 0,09221666 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02974487 0,09209978 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02974487 0,0919832 ! protein palmitoylation GO:0018345 12 5 0,000 0,02974487 0,09186691 ! drug metabolic process GO:0017144 7 5 0,000 0,02974487 0,09175092 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02974487 0,09163522 ! organ regeneration GO:0031100 7 5 0,000 0,02974487 0,09151981 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02974487 0,09140469 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02974487 0,09128986 ! biopolymer methylation GO:0043414 91 45 1,000 0,03014795 0,09241085 ! B cell differentiation GO:0030183 124 45 1,000 0,03014795 0,09229505 ! female gamete generation GO:0007292 71 45 1,000 0,03014795 0,09217954 ! maintenance of location in cell GO:0051651 101 45 1,000 0,03014795 0,09206431 ! glycolysis GO:0006096 71 46 1,000 0,03139561 0,09575464 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,03266337 0,09949703 ! mitochondrial transport GO:0006839 94 48 1,000 0,03395096 0,1032904 ! cellular component disassembly GO:0022411 89 48 1,000 0,03395096 0,10316193 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,03395096 0,10303377 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,03395096 0,10290594 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,03395096 0,10277842 ! methylation GO:0032259 97 48 1,000 0,03395096 0,10265122 ! JNK cascade GO:0007254 106 49 1,000 0,03525809 0,10647157 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03558732 0,10733311 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03558732 0,10720076 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03558732 0,10706874 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03558732 0,10693704 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03558732 0,10680567 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03558732 0,10667462 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03558732 0,10654389 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03558732 0,10641348 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03558732 0,10628339 ! response to oxygen radical GO:0000305 11 6 0,000 0,03558732 0,10615362 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03558732 0,10602417 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03558732 0,10589503 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03558732 0,1057662 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03558732 0,10563769 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03558732 0,10550949 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03558732 0,1053816 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03558732 0,10525402 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03558732 0,10512674 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03558732 0,10499978 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03558732 0,10487312 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03558732 0,10474677 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03558732 0,10462072 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03558732 0,10449497 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03558732 0,10436953 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03558732 0,10424438 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03558732 0,10411954 ! malate metabolic process GO:0006108 13 6 0,000 0,03558732 0,103995 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03558732 0,10387075 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03558732 0,1037468 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03558732 0,10362314 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03558732 0,10349978 ! protein refolding GO:0042026 15 6 0,000 0,03558732 0,10337671 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03558732 0,10325394 ! opsonization GO:0008228 8 6 0,000 0,03558732 0,10313145 ! mating behavior GO:0007617 7 6 0,000 0,03558732 0,10300926 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03558732 0,10288736 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03558732 0,10276574 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03558732 0,10264441 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03558732 0,10252337 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03558732 0,10240261 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03558732 0,10228214 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03558732 0,10216195 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03558732 0,10204204 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03558732 0,10192241 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03558732 0,10180306 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03558732 0,101684 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03558732 0,10156521 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03558732 0,10144669 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03558732 0,10132846 ! thymic T cell selection GO:0045061 16 6 0,000 0,03558732 0,1012105 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03558732 0,10109281 ! protein lipoylation GO:0009249 10 6 0,000 0,03558732 0,1009754 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03558732 0,10085826 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03558732 0,10074139 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03558732 0,10062479 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03558732 0,10050846 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03558732 0,1003924 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03558732 0,1002766 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03558732 0,10016108 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03558732 0,10004582 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03558732 0,09993082 ! hyperosmotic response GO:0006972 10 6 0,000 0,03558732 0,09981609 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03558732 0,09970162 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03558732 0,09958742 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03558732 0,09947347 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03558732 0,09935979 ! urea metabolic process GO:0019627 7 6 0,000 0,03558732 0,09924637 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03558732 0,0991332 ! neutrophil activation GO:0042119 7 6 0,000 0,03558732 0,09902029 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03558732 0,09890764 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03558732 0,09879525 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03558732 0,09868311 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03558732 0,09857122 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03558732 0,09845959 ! neuron apoptosis GO:0051402 15 6 0,000 0,03558732 0,09834821 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03558732 0,09823708 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03558732 0,0981262 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03558732 0,09801558 ! carnitine transport GO:0015879 10 6 0,000 0,03558732 0,0979052 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03558732 0,09779507 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03558732 0,09768519 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03558732 0,09757555 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,03558732 0,09746616 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03558732 0,09735702 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03558732 0,09724812 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03558732 0,09713946 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03558732 0,09703105 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03558732 0,09692287 ! astrocyte development GO:0014002 16 6 0,000 0,03558732 0,09681494 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03558732 0,09670725 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03558732 0,0965998 ! interaction with symbiont GO:0051702 14 6 0,000 0,03558732 0,09649258 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03558732 0,09638561 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03558732 0,09627887 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03558732 0,09617236 ! response to copper ion GO:0046688 10 6 0,000 0,03558732 0,0960661 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03558732 0,09596006 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03558732 0,09585426 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03558732 0,0957487 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03558732 0,09564336 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03558732 0,09553826 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03558732 0,09543339 ! hair follicle maturation GO:0048820 8 6 0,000 0,03558732 0,09532875 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03558732 0,09522433 ! Schwann cell development GO:0014044 15 6 0,000 0,03558732 0,09512015 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03558732 0,09501619 ! response to pheromone GO:0019236 6 6 0,000 0,03558732 0,09491246 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03558732 0,09480896 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03558732 0,09470568 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,03558732 0,09460263 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03558732 0,0944998 ! subpallium development GO:0021544 15 6 0,000 0,03558732 0,09439719 ! neural tube patterning GO:0021532 8 6 0,000 0,03558732 0,09429481 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03558732 0,09419265 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03558732 0,09409071 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03558732 0,09398899 ! G2 phase GO:0051319 16 6 0,000 0,03558732 0,09388749 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03558732 0,09378621 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03558732 0,09368515 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03558732 0,0935843 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03558732 0,09348367 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03558732 0,09338326 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03558732 0,09328306 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03558732 0,09318308 ! receptor internalization GO:0031623 11 6 0,000 0,03558732 0,09308332 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03558732 0,09298376 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03558732 0,09288442 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03558732 0,09278529 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03558732 0,09268637 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03558732 0,09258766 ! protein deubiquitination GO:0016579 16 6 0,000 0,03558732 0,09248917 ! protein destabilization GO:0031648 9 6 0,000 0,03558732 0,09239088 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03558732 0,0922928 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03558732 0,09219493 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03558732 0,09209726 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03558732 0,09199981 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03558732 0,09190255 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03558732 0,09180551 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03558732 0,09170867 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03558732 0,09161203 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03558732 0,0915156 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03558732 0,09141937 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03558732 0,09132334 ! neural plate development GO:0001840 9 6 0,000 0,03558732 0,09122751 ! catecholamine transport GO:0051937 9 6 0,000 0,03558732 0,09113188 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03558732 0,09103646 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03558732 0,09094123 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03558732 0,0908462 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03558732 0,09075137 ! maternal placenta development GO:0001893 12 6 0,000 0,03558732 0,09065674 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03558732 0,09056231 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03558732 0,09046807 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03558732 0,09037403 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03558732 0,09028018 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03558732 0,09018653 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03558732 0,09009307 GO:0055081|anion homeostasis, ! regulation of action potential GO:0001508 102 50 1,000 0,03658448 0,09252161 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,03658448 0,09242593 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,03658448 0,09233045 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,03792985 0,09562707 ! peptide metabolic process GO:0006518 80 51 1,000 0,03792985 0,09552848 ! positive regulation of binding GO:0051099 88 52 1,000 0,03929394 0,09886209 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,03929394 0,09876039 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,03929394 0,09865888 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,03929394 0,09855759 ! histone modification GO:0016570 104 52 1,000 0,03929394 0,09845651 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,03929394 0,09835563 ! amino acid activation GO:0043038 98 52 1,000 0,03929394 0,09825496 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,04067647 0,10160798 ! tRNA transcription GO:0009304 17 7 0,000 0,04139474 0,10329659 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04139474 0,10319118 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,04139474 0,10308599 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04139474 0,10298102 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04139474 0,10287626 ! sleep GO:0030431 16 7 0,000 0,04139474 0,10277171 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04139474 0,10266737 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04139474 0,10256324 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04139474 0,10245933 ! prostate gland development GO:0030850 14 7 0,000 0,04139474 0,10235563 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04139474 0,10225213 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04139474 0,10214885 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04139474 0,10204577 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04139474 0,1019429 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04139474 0,10184024 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04139474 0,10173779 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04139474 0,10163554 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04139474 0,10153349 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04139474 0,10143165 ! glycolipid transport GO:0046836 11 7 0,000 0,04139474 0,10133002 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04139474 0,10122859 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04139474 0,10112736 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04139474 0,10102633 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04139474 0,10092551 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04139474 0,10082488 ! pericardium development GO:0060039 16 7 0,000 0,04139474 0,10072446 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04139474 0,10062424 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04139474 0,10052421 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,04139474 0,10042439 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04139474 0,10032476 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,04139474 0,10022533 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04139474 0,1001261 ! lipoprotein transport GO:0042953 14 7 0,000 0,04139474 0,10002706 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04139474 0,09992822 ! rhythmic behavior GO:0007622 17 7 0,000 0,04139474 0,09982957 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04139474 0,09973112 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04139474 0,09963287 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04139474 0,0995348 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04139474 0,09943693 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04139474 0,09933925 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04139474 0,09924177 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04139474 0,09914447 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04139474 0,09904736 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04139474 0,09895045 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04139474 0,09885372 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04139474 0,09875719 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04139474 0,09866084 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04139474 0,09856468 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04139474 0,0984687 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04139474 0,09837292 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04139474 0,09827732 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04139474 0,0981819 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04139474 0,09808667 ! adrenal gland development GO:0030325 17 7 0,000 0,04139474 0,09799163 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04139474 0,09789677 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04139474 0,09780209 ! ovulation GO:0030728 10 7 0,000 0,04139474 0,09770759 ! adenohypophysis development GO:0021984 11 7 0,000 0,04139474 0,09761328 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04139474 0,09751915 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04139474 0,0974252 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04139474 0,09733143 ! microtubule nucleation GO:0007020 21 7 0,000 0,04139474 0,09723785 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04139474 0,09714444 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04139474 0,09705121 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04139474 0,09695816 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04139474 0,09686529 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04139474 0,09677259 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04139474 0,09668008 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04139474 0,09658774 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04139474 0,09649557 ! galactose metabolic process GO:0006012 13 7 0,000 0,04139474 0,09640358 ! vesicle fusion GO:0006906 20 7 0,000 0,04139474 0,09631177 ! response to dietary excess GO:0002021 8 7 0,000 0,04139474 0,09622013 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04139474 0,09612867 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04139474 0,09603738 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04139474 0,09594626 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,04139474 0,09585532 ! organ growth GO:0035265 15 7 0,000 0,04139474 0,09576454 ! nucleoside transport GO:0015858 11 7 0,000 0,04139474 0,09567394 ! nucleoside salvage GO:0043174 11 7 0,000 0,04139474 0,09558351 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04139474 0,09549326 ! male sex determination GO:0030238 15 7 0,000 0,04139474 0,09540317 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04139474 0,09531325 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04139474 0,0952235 ! parturition GO:0007567 16 7 0,000 0,04139474 0,09513392 ! rRNA modification GO:0000154 14 7 0,000 0,04139474 0,09504451 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04139474 0,09495527 ! spindle checkpoint GO:0031577 16 7 0,000 0,04139474 0,09486619 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04139474 0,09477728 ! monocyte differentiation GO:0030224 16 7 0,000 0,04139474 0,09468854 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04139474 0,09459996 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04139474 0,09451155 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04139474 0,0944233 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04139474 0,09433522 ! fibrinolysis GO:0042730 11 7 0,000 0,04139474 0,09424731 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,04139474 0,09415955 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04139474 0,09407196 ! eating behavior GO:0042755 8 7 0,000 0,04139474 0,09398453 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04139474 0,09389727 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04139474 0,09381017 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04139474 0,09372322 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04139474 0,09363644 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04139474 0,09354982 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04139474 0,09346336 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04139474 0,09337706 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04139474 0,09329092 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04139474 0,09320494 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04139474 0,09311911 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04139474 0,09303345 ! histone ubiquitination GO:0016574 9 7 0,000 0,04139474 0,09294794 ! regulation of meiosis GO:0040020 12 7 0,000 0,04139474 0,09286259 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04139474 0,09277739 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04139474 0,09269235 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04139474 0,09260747 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04139474 0,09252274 ! transcription termination GO:0006353 14 7 0,000 0,04139474 0,09243817 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04139474 0,09235375 ! anaphase GO:0051322 18 7 0,000 0,04139474 0,09226949 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04139474 0,09218538 ! axonal fasciculation GO:0007413 19 7 0,000 0,04139474 0,09210142 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04139474 0,09201761 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04139474 0,09193396 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04139474 0,09185046 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,04139474 0,09176711 ! diuresis GO:0030146 12 7 0,000 0,04139474 0,09168392 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04139474 0,09160087 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04139474 0,09151797 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04139474 0,09143522 ! antibiotic transport GO:0042891 9 7 0,000 0,04139474 0,09135263 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04139474 0,09127018 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04139474 0,09118788 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04139474 0,09110573 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04139474 0,09102373 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04139474 0,09094187 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04139474 0,09086016 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04139474 0,0907786 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04139474 0,09069718 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,04139474 0,09061591 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04139474 0,09053479 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04139474 0,09045381 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04139474 0,09037297 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04139474 0,09029228 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04139474 0,09021174 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04139474 0,09013134 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04139474 0,09005108 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04139474 0,08997096 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04139474 0,08989099 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04139474 0,08981115 ! muscle adaptation GO:0043500 13 7 0,000 0,04139474 0,08973146 ! retina homeostasis GO:0001895 12 7 0,000 0,04139474 0,08965191 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04139474 0,08957251 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04139474 0,08949324 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04139474 0,08941411 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04139474 0,08933512 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,04207716 0,09072772 GO:0010863|positive regulation of phospholipase C activity, ! membrane fusion GO:0006944 122 54 1,000 0,04207716 0,09064771 ! covalent chromatin modification GO:0016569 115 54 1,000 0,04207716 0,09056785 ! regulation of cell shape GO:0008360 142 54 1,000 0,04207716 0,09048812 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,04349576 0,09345659 ! cell recognition GO:0008037 98 55 1,000 0,04349576 0,09337447 ! cell maturation GO:0048469 107 55 1,000 0,04349576 0,09329249 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,044932 0,09628848 ! glucose catabolic process GO:0006007 88 56 1,000 0,044932 0,0962041 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,044932 0,09611985 ! RNA elongation GO:0006354 90 56 1,000 0,044932 0,09603576 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,04638561 0,09905599 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,04638561 0,09896948 ! heart morphogenesis GO:0003007 105 57 1,000 0,04638561 0,09888312 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04716736 0,10046196 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04716736 0,10037445 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,04716736 0,10028709 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04716736 0,10019988 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04716736 0,10011283 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04716736 0,10002592 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04716736 0,09993917 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04716736 0,09985257 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04716736 0,09976612 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04716736 0,09967981 ! meiotic prophase I GO:0007128 14 8 0,000 0,04716736 0,09959366 ! response to zinc ion GO:0010043 12 8 0,000 0,04716736 0,09950766 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04716736 0,0994218 ! oligopeptide transport GO:0006857 16 8 0,000 0,04716736 0,09933609 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04716736 0,09925053 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04716736 0,09916512 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04716736 0,09907985 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04716736 0,09899473 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04716736 0,09890975 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04716736 0,09882493 ! succinate metabolic process GO:0006105 17 8 0,000 0,04716736 0,09874024 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04716736 0,09865571 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04716736 0,09857131 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,04716736 0,09848706 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04716736 0,09840296 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04716736 0,098319 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04716736 0,09823518 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04716736 0,0981515 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04716736 0,09806797 ! reflex GO:0060004 17 8 0,000 0,04716736 0,09798458 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04716736 0,09790133 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04716736 0,09781822 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04716736 0,09773525 ! pigment granule organization GO:0048753 17 8 0,000 0,04716736 0,09765243 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04716736 0,09756974 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04716736 0,0974872 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04716736 0,09740479 ! histidine catabolic process GO:0006548 10 8 0,000 0,04716736 0,09732252 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04716736 0,09724039 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04716736 0,0971584 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04716736 0,09707655 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04716736 0,09699484 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,04716736 0,09691326 ! melanin metabolic process GO:0006582 17 8 0,000 0,04716736 0,09683182 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04716736 0,09675052 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04716736 0,09666935 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04716736 0,09658832 ! macrophage activation GO:0042116 13 8 0,000 0,04716736 0,09650742 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04716736 0,09642666 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04716736 0,09634604 ! purine salvage GO:0043101 12 8 0,000 0,04716736 0,09626555 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04716736 0,0961852 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04716736 0,09610497 ! osteoblast development GO:0002076 17 8 0,000 0,04716736 0,09602489 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04716736 0,09594493 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04716736 0,09586511 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04716736 0,09578542 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04716736 0,09570587 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04716736 0,09562644 ! response to UV-B GO:0010224 17 8 0,000 0,04716736 0,09554715 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04716736 0,09546799 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04716736 0,09538896 ! intermediate filament organization GO:0045109 12 8 0,000 0,04716736 0,09531006 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04716736 0,09523129 ! cellular extravasation GO:0045123 13 8 0,000 0,04716736 0,09515265 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04716736 0,09507415 ! response to antibiotic GO:0046677 11 8 0,000 0,04716736 0,09499577 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04716736 0,09491752 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04716736 0,09483939 ! DNA topological change GO:0006265 12 8 0,000 0,04716736 0,0947614 ! response to tropane GO:0014073 15 8 0,000 0,04716736 0,09468354 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04716736 0,0946058 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04716736 0,09452819 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04716736 0,09445071 ! mast cell activation GO:0045576 14 8 0,000 0,04716736 0,09437335 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04716736 0,09429612 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04716736 0,09421902 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04716736 0,09414205 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04716736 0,0940652 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04716736 0,09398847 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04716736 0,09391187 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04716736 0,09383539 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04716736 0,09375904 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04716736 0,09368282 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04716736 0,09360671 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04716736 0,09353073 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04716736 0,09345488 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04716736 0,09337914 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04716736 0,09330353 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04716736 0,09322805 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04716736 0,09315268 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04716736 0,09307744 ! hormone catabolic process GO:0042447 17 8 0,000 0,04716736 0,09300231 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04716736 0,09292731 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04716736 0,09285243 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04716736 0,09277767 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04716736 0,09270303 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04716736 0,09262851 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04716736 0,09255411 ! adult feeding behavior GO:0008343 10 8 0,000 0,04716736 0,09247983 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04716736 0,09240567 ! ATP catabolic process GO:0006200 11 8 0,000 0,04716736 0,09233162 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04716736 0,0922577 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04716736 0,09218389 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04716736 0,0921102 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04716736 0,09203663 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04716736 0,09196318 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04716736 0,09188984 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04716736 0,09181663 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04716736 0,09174352 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04716736 0,09167054 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04716736 0,09159767 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04716736 0,09152491 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04716736 0,09145227 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04716736 0,09137975 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04716736 0,09130734 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04716736 0,09123505 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04716736 0,09116287 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04716736 0,0910908 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04716736 0,09101885 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04716736 0,09094701 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,04785635 0,09220273 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,04785635 0,09213007 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,04785635 0,09205753 ! maintenance of location GO:0051235 124 58 1,000 0,04785635 0,0919851 ! nuclear export GO:0051168 110 59 1,000 0,04934394 0,09476986 ! establishment of organelle localization GO:0051656 122 59 1,000 0,04934394 0,09469541 ! DNA catabolic process GO:0006308 94 60 1,000 0,05084815 0,09750552 ! camera-type eye development GO:0043010 126 61 1,000 0,05236871 0,10034255 ! axon extension GO:0048675 16 9 0,000 0,05290538 0,10129141 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,05290538 0,10121209 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,05290538 0,1011329 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05290538 0,10105382 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,05290538 0,10097488 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,05290538 0,10089605 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,05290538 0,10081735 ! reproductive behavior GO:0019098 22 9 0,000 0,05290538 0,10073877 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05290538 0,10066031 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,05290538 0,10058198 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,05290538 0,10050376 ! UTP metabolic process GO:0046051 10 9 0,000 0,05290538 0,10042567 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,05290538 0,1003477 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,05290538 0,10026985 ! artery development GO:0060840 25 9 0,000 0,05290538 0,10019212 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,05290538 0,10011452 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,05290538 0,10003703 ! equilibrioception GO:0050957 20 9 0,000 0,05290538 0,09995966 ! chemosensory behavior GO:0007635 21 9 0,000 0,05290538 0,09988241 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,05290538 0,09980528 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05290538 0,09972827 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,05290538 0,09965138 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,05290538 0,09957461 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,05290538 0,09949795 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,05290538 0,09942142 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05290538 0,099345 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05290538 0,0992687 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,05290538 0,09919251 ! protein targeting to ER GO:0045047 25 9 0,000 0,05290538 0,09911644 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,05290538 0,09904049 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,05290538 0,09896466 ! T cell selection GO:0045058 27 9 0,000 0,05290538 0,09888894 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,05290538 0,09881333 ! glycine catabolic process GO:0006546 15 9 0,000 0,05290538 0,09873785 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,05290538 0,09866247 ! endosome organization GO:0007032 20 9 0,000 0,05290538 0,09858722 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05290538 0,09851207 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,05290538 0,09843705 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05290538 0,09836213 ! mannose metabolic process GO:0006013 13 9 0,000 0,05290538 0,09828733 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,05290538 0,09821265 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,05290538 0,09813807 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,05290538 0,09806361 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,05290538 0,09798927 ! receptor clustering GO:0043113 20 9 0,000 0,05290538 0,09791503 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,05290538 0,09784091 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05290538 0,0977669 ! retinol metabolic process GO:0042572 20 9 0,000 0,05290538 0,097693 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,05290538 0,09761922 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,05290538 0,09754554 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,05290538 0,09747198 ! macrophage differentiation GO:0030225 15 9 0,000 0,05290538 0,09739852 ! oligodendrocyte development GO:0014003 11 9 0,000 0,05290538 0,09732518 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05290538 0,09725195 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,05290538 0,09717883 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05290538 0,09710582 ! response to amine stimulus GO:0014075 13 9 0,000 0,05290538 0,09703291 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05290538 0,09696012 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,05290538 0,09688744 ! erythrocyte development GO:0048821 17 9 0,000 0,05290538 0,09681486 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05290538 0,0967424 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,05290538 0,09667004 ! renal water homeostasis GO:0003091 15 9 0,000 0,05290538 0,09659779 ! postreplication repair GO:0006301 25 9 0,000 0,05290538 0,09652565 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,05290538 0,09645361 ! icosanoid secretion GO:0032309 15 9 0,000 0,05290538 0,09638169 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05290538 0,09630987 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,05290538 0,09623815 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,05290538 0,09616655 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,05290538 0,09609505 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05290538 0,09602366 ! sterol catabolic process GO:0016127 14 9 0,000 0,05290538 0,09595237 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05290538 0,09588119 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,05290538 0,09581011 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,05290538 0,09573914 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,05290538 0,09566828 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,05290538 0,09559752 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,05290538 0,09552686 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,05290538 0,09545631 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,05290538 0,09538586 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05290538 0,09531552 ! purine base metabolic process GO:0006144 25 9 0,000 0,05290538 0,09524528 ! pigment granule transport GO:0051904 17 9 0,000 0,05290538 0,09517514 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,05290538 0,09510511 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,05290538 0,09503518 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,05290538 0,09496535 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05290538 0,09489562 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,05290538 0,094826 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,05290538 0,09475648 ! mitochondrion localization GO:0051646 18 9 0,000 0,05290538 0,09468706 ! mesoderm development GO:0007498 128 63 1,000 0,0554579 0,09918276 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,058609 0,10474162 ! regulation of developmental growth GO:0048638 16 10 0,000 0,058609 0,10466505 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,058609 0,1045886 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,058609 0,10451226 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,058609 0,10443603 ! associative learning GO:0008306 21 10 0,000 0,058609 0,10435991 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,058609 0,1042839 ! phosphate transport GO:0006817 24 10 0,000 0,058609 0,104208 ! cell volume homeostasis GO:0006884 17 10 0,000 0,058609 0,10413221 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,058609 0,10405654 ! CTP metabolic process GO:0046036 11 10 0,000 0,058609 0,10398097 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,058609 0,10390551 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,058609 0,10383016 ! GTP metabolic process GO:0046039 11 10 0,000 0,058609 0,10375492 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,058609 0,10367979 GO:0007520|myoblast fusion, ! social behavior GO:0035176 29 10 0,000 0,058609 0,10360477 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,058609 0,10352986 GO:0048200|Golgi transport vesicle coating, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,058609 0,10345505 ! androgen metabolic process GO:0008209 17 10 0,000 0,058609 0,10338036 ! phospholipid efflux GO:0033700 19 10 0,000 0,058609 0,10330577 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,058609 0,10323129 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,058609 0,10315691 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,058609 0,10308264 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,058609 0,10300848 ! pathogenesis GO:0009405 17 10 0,000 0,058609 0,10293443 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,058609 0,10286048 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,058609 0,10278664 ! endoderm development GO:0007492 18 10 0,000 0,058609 0,10271291 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,058609 0,10263928 ! arginine catabolic process GO:0006527 17 10 0,000 0,058609 0,10256575 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,058609 0,10249234 ! proline metabolic process GO:0006560 13 10 0,000 0,058609 0,10241902 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,058609 0,10234581 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,058609 0,10227271 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,058609 0,10219971 ! V(D)J recombination GO:0033151 34 10 0,000 0,058609 0,10212681 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,058609 0,10205402 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,058609 0,10198133 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,058609 0,10190875 ! B cell proliferation GO:0042100 19 10 0,000 0,058609 0,10183627 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,058609 0,10176389 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,058609 0,10169161 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,058609 0,10161944 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,058609 0,10154737 ! ruffle organization GO:0031529 17 10 0,000 0,058609 0,1014754 ! epithelial cell development GO:0002064 21 10 0,000 0,058609 0,10140354 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,058609 0,10133177 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,058609 0,10126011 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,058609 0,10118855 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,058609 0,10111708 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,058609 0,10104572 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,058609 0,10097447 ! protein heterooligomerization GO:0051291 17 10 0,000 0,058609 0,10090331 ! brain morphogenesis GO:0048854 23 10 0,000 0,058609 0,10083225 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,058609 0,10076129 ! segment specification GO:0007379 15 10 0,000 0,058609 0,10069043 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,058609 0,10061967 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,058609 0,10054901 ! blastoderm segmentation GO:0007350 19 10 0,000 0,058609 0,10047845 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,058609 0,10040799 ! response to dsRNA GO:0043331 23 10 0,000 0,058609 0,10033763 ! DNA ligation GO:0006266 18 10 0,000 0,058609 0,10026736 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,058609 0,1001972 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,058609 0,10012713 ! melanosome localization GO:0032400 16 10 0,000 0,058609 0,10005716 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,058609 0,09998729 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,058609 0,09991751 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,058609 0,09984783 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,058609 0,09977825 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,058609 0,09970877 ! protein sumoylation GO:0016925 17 10 0,000 0,058609 0,09963938 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,058609 0,09957009 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,058609 0,0995009 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,058609 0,0994318 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,058609 0,0993628 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,058609 0,09929389 ! salivary gland development GO:0007431 28 10 0,000 0,058609 0,09922508 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,058609 0,09915637 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,058609 0,09908775 ! midbrain development GO:0030901 14 10 0,000 0,058609 0,09901922 ! musculoskeletal movement GO:0050881 16 10 0,000 0,058609 0,09895079 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,058609 0,09888245 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,058609 0,09881421 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,058609 0,09874606 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,058609 0,09867801 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,058609 0,09861005 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,058609 0,09854218 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,058609 0,09847441 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,058609 0,09840673 ! detection of calcium ion GO:0005513 24 10 0,000 0,058609 0,09833914 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,058609 0,09827165 ! blastocyst formation GO:0001825 18 10 0,000 0,058609 0,09820425 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,058609 0,09813694 ! cerebellar cortex development GO:0021695 16 10 0,000 0,058609 0,09806972 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,058609 0,0980026 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,058609 0,09793556 ! response to nicotine GO:0035094 20 10 0,000 0,058609 0,09786862 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,058609 0,09780177 ! gonad development GO:0008406 115 66 1,000 0,0602082 0,10040179 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,0602082 0,1003333 ! activation of MAPK activity GO:0000187 124 67 1,000 0,06182173 0,10295194 ! chromosome segregation GO:0007059 127 67 1,000 0,06182173 0,10288181 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 1,000 0,06182173 0,10281178 ! secondary metabolic process GO:0019748 125 67 1,000 0,06182173 0,10274184 ! myeloid cell differentiation GO:0030099 126 67 1,000 0,06182173 0,10267199 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,06344993 0,10530448 ! hexose catabolic process GO:0019320 113 68 1,000 0,06344993 0,10523299 ! regulation of lipase activity GO:0060191 137 68 1,000 0,06344993 0,10516159 ! adaptive immune response GO:0002250 126 68 1,000 0,06344993 0,1050903 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 1,000 0,06344993 0,1050191 ! respiratory burst GO:0045730 17 11 0,000 0,06427844 0,10631836 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,06427844 0,10624643 ! telencephalon cell migration GO:0022029 23 11 0,000 0,06427844 0,10617459 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,06427844 0,10610285 ! synapsis GO:0007129 14 11 0,000 0,06427844 0,10603121 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,06427844 0,10595966 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,06427844 0,10588821 ! response to pain GO:0048265 27 11 0,000 0,06427844 0,10581686 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,06427844 0,1057456 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,06427844 0,10567444 ! bone resorption GO:0045453 16 11 0,000 0,06427844 0,10560338 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,06427844 0,10553241 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06427844 0,10546153 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06427844 0,10539075 ! melanocyte differentiation GO:0030318 20 11 0,000 0,06427844 0,10532007 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,06427844 0,10524948 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,06427844 0,10517898 ! L-serine metabolic process GO:0006563 21 11 0,000 0,06427844 0,10510858 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,06427844 0,10503827 ! UV protection GO:0009650 20 11 0,000 0,06427844 0,10496806 ! adult heart development GO:0007512 16 11 0,000 0,06427844 0,10489794 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,06427844 0,10482792 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06427844 0,10475799 ! macroautophagy GO:0016236 19 11 0,000 0,06427844 0,10468815 ! temperature homeostasis GO:0001659 18 11 0,000 0,06427844 0,1046184 ! behavioral fear response GO:0001662 27 11 0,000 0,06427844 0,10454875 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,06427844 0,10447919 ! negative regulation of ossification GO:0030279 27 11 0,000 0,06427844 0,10440972 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,06427844 0,10434035 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,06427844 0,10427106 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,06427844 0,10420187 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,06427844 0,10413277 ! regulation of organ growth GO:0046620 14 11 0,000 0,06427844 0,10406376 ! pigment granule localization GO:0051875 20 11 0,000 0,06427844 0,10399485 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,06427844 0,10392602 ! vasoconstriction GO:0042310 20 11 0,000 0,06427844 0,10385729 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,06427844 0,10378865 ! embryonic axis specification GO:0000578 19 11 0,000 0,06427844 0,10372009 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,06427844 0,10365163 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06427844 0,10358326 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,06427844 0,10351498 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,06427844 0,10344679 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,06427844 0,10337868 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,06427844 0,10331067 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,06427844 0,10324275 ! prophase GO:0051324 17 11 0,000 0,06427844 0,10317491 ! nucleosome positioning GO:0016584 15 11 0,000 0,06427844 0,10310717 ! regulation of isotype switching GO:0045191 24 11 0,000 0,06427844 0,10303951 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,06427844 0,10297195 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,06427844 0,10290447 ! apical protein localization GO:0045176 18 11 0,000 0,06427844 0,10283708 ! acid secretion GO:0046717 20 11 0,000 0,06427844 0,10276978 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06427844 0,10270256 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,06427844 0,10263544 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,06427844 0,1025684 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,06427844 0,10250145 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,06427844 0,10243459 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,06427844 0,10236781 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06427844 0,10230112 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,06427844 0,10223452 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,06427844 0,102168 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,06427844 0,10210157 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,06427844 0,10203523 ! activation of innate immune response GO:0002218 16 11 0,000 0,06427844 0,10196897 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,06427844 0,1019028 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,06427844 0,10183672 ! lysogeny GO:0030069 22 11 0,000 0,06427844 0,10177072 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06427844 0,10170481 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,06427844 0,10163898 ! sequestering of metal ion GO:0051238 15 11 0,000 0,06427844 0,10157323 ! regulation of embryonic development GO:0045995 35 11 0,000 0,06427844 0,10150758 ! nucleus localization GO:0051647 22 11 0,000 0,06427844 0,101442 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,06509256 0,1026605 ! developmental maturation GO:0021700 128 69 1,000 0,06509256 0,10259427 ! single fertilization GO:0007338 83 69 1,000 0,06509256 0,10252812 ! germ cell development GO:0007281 133 70 1,000 0,06674938 0,10507006 ! protein maturation by peptide bond cleavage GO:0051605 118 70 1,000 0,06674938 0,1050024 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06991389 0,10990967 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06991389 0,10983899 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06991389 0,10976839 ! virus-host interaction GO:0019048 30 12 0,000 0,06991389 0,10969789 ! mating GO:0007618 17 12 0,000 0,06991389 0,10962749 ! protein complex disassembly GO:0043241 28 12 0,000 0,06991389 0,10955717 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06991389 0,10948694 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,06991389 0,1094168 ! T cell proliferation GO:0042098 32 12 0,000 0,06991389 0,10934675 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06991389 0,10927679 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06991389 0,10920692 ! drug transport GO:0015893 16 12 0,000 0,06991389 0,10913714 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06991389 0,10906745 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06991389 0,10899784 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06991389 0,10892833 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06991389 0,10885891 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06991389 0,10878957 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06991389 0,10872032 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06991389 0,10865116 ! lipid digestion GO:0044241 21 12 0,000 0,06991389 0,10858209 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06991389 0,1085131 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06991389 0,1084442 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06991389 0,10837539 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06991389 0,10830667 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06991389 0,10823804 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06991389 0,10816949 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06991389 0,10810103 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06991389 0,10803265 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06991389 0,10796436 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06991389 0,10789616 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06991389 0,10782804 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06991389 0,10776001 ! fucose catabolic process GO:0019317 25 12 0,000 0,06991389 0,10769207 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06991389 0,10762421 ! zymogen activation GO:0031638 18 12 0,000 0,06991389 0,10755644 ! T cell homeostasis GO:0043029 28 12 0,000 0,06991389 0,10748875 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06991389 0,10742115 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06991389 0,10735363 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06991389 0,10728619 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06991389 0,10721885 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06991389 0,10715158 ! defense response to fungus GO:0050832 15 12 0,000 0,06991389 0,1070844 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06991389 0,10701731 ! response to cold GO:0009409 17 12 0,000 0,06991389 0,1069503 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06991389 0,10688337 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06991389 0,10681652 ! carbohydrate transport GO:0008643 114 72 1,000 0,0701047 0,10704111 ! actin filament organization GO:0007015 167 72 1,000 0,0701047 0,10697425 ! B cell activation GO:0042113 179 72 1,000 0,0701047 0,10690747 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,0701047 0,10684078 ! organelle localization GO:0051640 155 74 1,000 0,07351408 0,11196689 ! reproductive structure development GO:0048608 131 75 1,000 0,07523849 0,11452189 ! eye development GO:0001654 155 75 1,000 0,07523849 0,11445058 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,07551555 0,11480056 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07551555 0,11472916 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,07551555 0,11465786 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,07551555 0,11458664 ! peroxisomal transport GO:0043574 28 13 0,000 0,07551555 0,11451551 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,07551555 0,11444448 ! organelle fusion GO:0048284 36 13 0,000 0,07551555 0,11437352 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,07551555 0,11430266 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,07551555 0,11423189 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,07551555 0,1141612 ! endocrine pancreas development GO:0031018 25 13 0,000 0,07551555 0,1140906 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,07551555 0,11402008 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,07551555 0,11394966 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,07551555 0,11387932 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,07551555 0,11380907 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,07551555 0,1137389 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,07551555 0,11366882 ! methionine metabolic process GO:0006555 31 13 0,000 0,07551555 0,11359883 ! plasma membrane organization GO:0007009 27 13 0,000 0,07551555 0,11352892 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,07551555 0,1134591 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,07551555 0,11338936 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,07551555 0,11331971 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,07551555 0,11325015 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,07551555 0,11318067 ! exocrine system development GO:0035272 34 13 0,000 0,07551555 0,11311128 ! asymmetric protein localization GO:0008105 24 13 0,000 0,07551555 0,11304197 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,07551555 0,11297275 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,07551555 0,11290361 ! L-glutamate transport GO:0015813 30 13 0,000 0,07551555 0,11283455 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,07551555 0,11276558 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,07551555 0,1126967 ! protein homotetramerization GO:0051289 24 13 0,000 0,07551555 0,1126279 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,07551555 0,11255918 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,07551555 0,11249055 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,07551555 0,112422 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,07551555 0,11235353 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,07551555 0,11228515 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07551555 0,11221685 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,07551555 0,11214863 ! histone methylation GO:0016571 29 13 0,000 0,07551555 0,11208049 ! chromatin silencing GO:0006342 29 13 0,000 0,07551555 0,11201244 ! gland morphogenesis GO:0022612 31 13 0,000 0,07551555 0,11194447 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,07551555 0,11187659 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07551555 0,11180878 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,07551555 0,11174106 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,07551555 0,11167342 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,07551555 0,11160586 ! spleen development GO:0048536 24 13 0,000 0,07551555 0,11153839 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,07551555 0,11147099 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,07551555 0,11140368 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,07551555 0,11133645 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07551555 0,1112693 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,07551555 0,11120223 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,07551555 0,11113524 ! insulin secretion GO:0030073 24 13 0,000 0,07551555 0,11106833 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,07551555 0,1110015 ! acrosome reaction GO:0007340 19 13 0,000 0,07551555 0,11093475 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,07551555 0,11086809 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,07551555 0,1108015 ! learning or memory GO:0007611 161 76 1,000 0,07697576 0,11287622 ! regulation of blood pressure GO:0008217 134 76 1,000 0,07697576 0,11280851 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,07697576 0,11274088 ! monosaccharide catabolic process GO:0046365 125 77 1,000 0,07872567 0,11523476 ! fertilization GO:0009566 99 78 1,000 0,08048801 0,11774384 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,08048801 0,11767338 ! rRNA transcription GO:0009303 28 14 0,000 0,08108364 0,11847328 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,08108364 0,11840247 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,08108364 0,11833174 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,08108364 0,11826109 ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,08108364 0,11819053 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,08108364 0,11812005 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,08108364 0,11804966 ! lipid localization GO:0010876 32 14 0,000 0,08108364 0,11797935 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,08108364 0,11790912 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,08108364 0,11783898 ! regulated secretory pathway GO:0045055 24 14 0,000 0,08108364 0,11776892 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,08108364 0,11769895 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,08108364 0,11762906 ! arginine metabolic process GO:0006525 21 14 0,000 0,08108364 0,11755925 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,08108364 0,11748952 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,08108364 0,11741988 ! regulation of heart rate GO:0002027 25 14 0,000 0,08108364 0,11735031 ! fear response GO:0042596 34 14 0,000 0,08108364 0,11728083 ! organic alcohol transport GO:0015850 29 14 0,000 0,08108364 0,11721144 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,08108364 0,11714212 ! neutral amino acid transport GO:0015804 28 14 0,000 0,08108364 0,11707289 ! bone mineralization GO:0030282 18 14 0,000 0,08108364 0,11700374 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,08108364 0,11693467 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,08108364 0,11686568 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,08108364 0,11679677 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,08108364 0,11672795 ! ribosome assembly GO:0042255 18 14 0,000 0,08108364 0,1166592 ! cerebellum development GO:0021549 23 14 0,000 0,08108364 0,11659054 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,08108364 0,11652196 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,08108364 0,11645346 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,08108364 0,11638503 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,08108364 0,11631669 ! NADP metabolic process GO:0006739 24 14 0,000 0,08108364 0,11624843 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,08108364 0,11618025 ! oxygen transport GO:0015671 22 14 0,000 0,08108364 0,11611215 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,08108364 0,11604413 ! male genitalia development GO:0030539 26 14 0,000 0,08108364 0,11597619 ! regulation of axon extension GO:0030516 43 14 0,000 0,08108364 0,11590833 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,08108364 0,11584054 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,08108364 0,11577284 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,08226257 0,11738753 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,08404913 0,11986691 ! muscle cell differentiation GO:0042692 178 81 1,000 0,08584749 0,12236022 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,08584749 0,12228887 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,08584749 0,12221761 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,08661834 0,12324322 ! lactation GO:0007595 30 15 0,000 0,08661834 0,12317149 ! reproductive cellular process GO:0048610 22 15 0,000 0,08661834 0,12309983 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08661834 0,12302826 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,08661834 0,12295678 ! superoxide anion generation GO:0042554 22 15 0,000 0,08661834 0,12288537 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,08661834 0,12281405 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,08661834 0,12274282 ! copper ion transport GO:0006825 22 15 0,000 0,08661834 0,12267166 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,08661834 0,12260059 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,08661834 0,1225296 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,08661834 0,12245869 ! sulfate transport GO:0008272 27 15 0,000 0,08661834 0,12238786 ! response to cAMP GO:0051591 25 15 0,000 0,08661834 0,12231712 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,08661834 0,12224646 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,08661834 0,12217588 ! response to hexose stimulus GO:0009746 25 15 0,000 0,08661834 0,12210538 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,08661834 0,12203496 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,08661834 0,12196462 ! vesicle coating GO:0006901 38 15 0,000 0,08661834 0,12189436 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,08661834 0,12182419 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,08661834 0,12175409 ! regulation of exocytosis GO:0017157 26 15 0,000 0,08661834 0,12168408 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,08661834 0,12161415 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,08661834 0,12154429 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,08661834 0,12147452 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,08661834 0,12140483 ! regulation of vasodilation GO:0042312 27 15 0,000 0,08661834 0,12133522 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,08661834 0,12126568 ! histone deacetylation GO:0016575 24 15 0,000 0,08661834 0,12119623 ! water homeostasis GO:0030104 28 15 0,000 0,08661834 0,12112686 ! cofactor transport GO:0051181 30 15 0,000 0,08661834 0,12105756 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08661834 0,12098835 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,08661834 0,12091921 ! intestinal absorption GO:0050892 31 15 0,000 0,08661834 0,12085015 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08661834 0,12078117 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,08661834 0,12071227 ! heme biosynthetic process GO:0006783 33 15 0,000 0,08661834 0,12064345 ! cell killing GO:0001906 32 15 0,000 0,08661834 0,12057471 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,08661834 0,12050605 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,08661834 0,12043746 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,08661834 0,12036895 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,08661834 0,12030052 ! actin filament polymerization GO:0030041 27 15 0,000 0,08661834 0,12023217 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,08661834 0,12016389 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,08947879 0,12406168 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,08947879 0,12399132 ! T cell activation GO:0042110 189 84 1,000 0,09131133 0,12645894 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,09211987 0,12750643 ! positive regulation of cell size GO:0045793 29 16 0,000 0,09211987 0,12743422 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,09211987 0,12736211 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,09211987 0,12729007 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,09211987 0,12721811 ! bone remodeling GO:0046849 28 16 0,000 0,09211987 0,12714624 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09211987 0,12707444 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,09211987 0,12700273 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,09211987 0,1269311 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,09211987 0,12685955 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,09211987 0,12678808 ! startle response GO:0001964 28 16 0,000 0,09211987 0,12671669 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,09211987 0,12664538 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,09211987 0,12657415 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,09211987 0,126503 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,09211987 0,12643193 ! protein polyubiquitination GO:0000209 41 16 0,000 0,09211987 0,12636094 ! glutamate metabolic process GO:0006536 25 16 0,000 0,09211987 0,12629003 ! pituitary gland development GO:0021983 30 16 0,000 0,09211987 0,1262192 ! response to osmotic stress GO:0006970 27 16 0,000 0,09211987 0,12614845 ! lysosomal transport GO:0007041 31 16 0,000 0,09211987 0,12607778 ! fructose metabolic process GO:0006000 25 16 0,000 0,09211987 0,12600719 ! L-amino acid transport GO:0015807 33 16 0,000 0,09211987 0,12593668 ! stem cell development GO:0048864 46 16 0,000 0,09211987 0,12586624 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,09211987 0,12579589 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,09211987 0,12572561 ! intermediate filament-based process GO:0045103 36 16 0,000 0,09211987 0,12565541 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,09211987 0,12558529 ! negative regulation of immune response GO:0050777 38 16 0,000 0,09211987 0,12551525 ! axon cargo transport GO:0008088 46 16 0,000 0,09211987 0,12544528 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,09211987 0,1253754 ! DNA replication initiation GO:0006270 28 16 0,000 0,09211987 0,12530559 ! mRNA splice site selection GO:0006376 44 16 0,000 0,09211987 0,12523586 ! tissue regeneration GO:0042246 27 16 0,000 0,09211987 0,12516621 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,09211987 0,12509663 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,09211987 0,12502713 ! biomineral formation GO:0031214 22 16 0,000 0,09211987 0,12495771 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,09211987 0,12488837 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,09211987 0,1248191 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,09211987 0,12474991 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,09211987 0,1246808 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,09211987 0,12461176 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,09211987 0,1245428 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,09211987 0,12447392 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,09500918 0,12830703 GO:0002696|positive regulation of leukocyte activation, ! alcohol catabolic process GO:0046164 142 87 1,000 0,0968741 0,13075327 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,09758841 0,13164466 ! metencephalon development GO:0022037 32 17 0,000 0,09758841 0,13157201 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,09758841 0,13149944 ! signal complex assembly GO:0007172 47 17 0,000 0,09758841 0,13142695 ! filopodium assembly GO:0046847 42 17 0,000 0,09758841 0,13135454 ! gene silencing by RNA GO:0031047 38 17 0,000 0,09758841 0,13128221 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,09758841 0,13120995 ! glial cell development GO:0021782 28 17 0,000 0,09758841 0,13113778 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,09758841 0,13106569 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,09758841 0,13099367 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,09758841 0,13092174 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,09758841 0,13084988 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,09758841 0,13077811 ! myoblast differentiation GO:0045445 50 17 0,000 0,09758841 0,13070641 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,09758841 0,13063479 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,09758841 0,13056325 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,09758841 0,13049178 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,09758841 0,1304204 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,09758841 0,13034909 ! NAD metabolic process GO:0019674 33 17 0,000 0,09758841 0,13027786 ! membrane budding GO:0006900 42 17 0,000 0,09758841 0,13020671 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,09758841 0,13013564 ! regulation of protein binding GO:0043393 33 17 0,000 0,09758841 0,13006464 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,09758841 0,12999372 ! genitalia development GO:0048806 32 17 0,000 0,09758841 0,12992288 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,09758841 0,12985212 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,09758841 0,12978143 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,09758841 0,12971082 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,09758841 0,12964029 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,09758841 0,12956983 ! steroid catabolic process GO:0006706 34 17 0,000 0,09758841 0,12949945 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,09758841 0,12942915 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,09758841 0,12935892 ! gas transport GO:0015669 26 17 0,000 0,09758841 0,12928877 ! organic cation transport GO:0015695 32 17 0,000 0,09758841 0,12921869 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,09758841 0,12914869 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,09874942 0,13061442 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,10302417 0,13619483 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,10302417 0,13612117 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,10302417 0,13604759 ! negative regulation of ion transport GO:0043271 25 18 0,000 0,10302417 0,13597409 ! adult walking behavior GO:0007628 36 18 0,000 0,10302417 0,13590067 ! patterning of blood vessels GO:0001569 43 18 0,000 0,10302417 0,13582733 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,10302417 0,13575407 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,10302417 0,13568088 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,10302417 0,13560778 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,10302417 0,13553475 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,10302417 0,13546181 ! glycine metabolic process GO:0006544 30 18 0,000 0,10302417 0,13538894 ! glutamine metabolic process GO:0006541 29 18 0,000 0,10302417 0,13531615 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,10302417 0,13524344 ! DNA integration GO:0015074 32 18 0,000 0,10302417 0,1351708 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,10302417 0,13509825 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,10302417 0,13502577 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,10302417 0,13495337 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,10302417 0,13488105 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,10302417 0,1348088 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,10302417 0,13473664 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,10302417 0,13466455 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,10302417 0,13459253 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,10302417 0,1345206 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,10302417 0,13444874 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,10302417 0,13437696 ! detection of bacterium GO:0016045 22 18 0,000 0,10302417 0,13430525 ! defense response to virus GO:0051607 43 18 0,000 0,10302417 0,13423362 ! microspike assembly GO:0030035 46 18 0,000 0,10302417 0,13416207 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,10302417 0,13409059 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,10827549 0,14085038 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,10842733 0,14097284 ! positive regulation of translation GO:0045727 31 19 0,000 0,10842733 0,14089786 ! negative regulation of defense response GO:0031348 27 19 0,000 0,10842733 0,14082295 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,10842733 0,14074812 ! neuron maturation GO:0042551 46 19 0,000 0,10842733 0,14067338 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,10842733 0,14059871 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,10842733 0,14052412 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,10842733 0,14044961 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,10842733 0,14037518 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,10842733 0,14030083 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,10842733 0,14022656 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,10842733 0,14015236 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,10842733 0,14007825 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,10842733 0,14000421 ! cerebral cortex development GO:0021987 40 19 0,000 0,10842733 0,13993025 ! pigmentation during development GO:0048066 42 19 0,000 0,10842733 0,13985637 ! heme metabolic process GO:0042168 40 19 0,000 0,10842733 0,13978257 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,10842733 0,13970884 ! response to fungus GO:0009620 26 19 0,000 0,10842733 0,1396352 ! peptide cross-linking GO:0018149 39 19 0,000 0,10842733 0,13956163 ! protein export from nucleus GO:0006611 40 19 0,000 0,10842733 0,13948814 ! heart process GO:0003015 32 19 0,000 0,10842733 0,13941472 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,10842733 0,13934138 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,10842733 0,13926812 ! visual learning GO:0008542 38 19 0,000 0,10842733 0,13919494 ! cellular pigmentation GO:0033059 37 19 0,000 0,10842733 0,13912183 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,10842733 0,1390488 ! vitamin transport GO:0051180 31 19 0,000 0,10842733 0,13897585 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,10842733 0,13890297 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,10842733 0,13883017 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,10842733 0,13875745 ! cilium assembly GO:0042384 38 19 0,000 0,10842733 0,1386848 ! peptide hormone secretion GO:0030072 32 19 0,000 0,10842733 0,13861223 ! female pregnancy GO:0007565 166 94 1,000 0,11020929 0,14081657 ! regulation of membrane potential GO:0042391 179 94 1,000 0,11020929 0,14074296 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,11215219 0,14314933 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,1137981 0,14517429 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,1137981 0,14509852 ! positive regulation of ossification GO:0045778 50 20 0,000 0,1137981 0,14502283 ! skin development GO:0043588 42 20 0,000 0,1137981 0,14494721 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,1137981 0,14487168 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,1137981 0,14479623 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,1137981 0,14472085 ! bile acid metabolic process GO:0008206 34 20 0,000 0,1137981 0,14464556 ! response to alkaloid GO:0043279 38 20 0,000 0,1137981 0,14457034 ! retinoid metabolic process GO:0001523 34 20 0,000 0,1137981 0,1444952 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,1137981 0,14442013 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,1137981 0,14434515 ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,1137981 0,14427024 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,1137981 0,14419541 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,1137981 0,14412066 ! peptide secretion GO:0002790 38 20 0,000 0,1137981 0,14404599 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,1137981 0,14397139 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,1137981 0,14389687 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,1137981 0,14382243 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,1137981 0,14374806 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,1137981 0,14367378 ! cell-cell junction organization GO:0045216 43 20 0,000 0,1137981 0,14359956 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,1137981 0,14352543 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,1137981 0,14345137 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,1137981 0,14337739 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,1137981 0,14330348 ! regulation of glucose import GO:0046324 30 20 0,000 0,1137981 0,14322965 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,1137981 0,1431559 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,1137981 0,14308222 ! negative regulation of translation GO:0017148 32 20 0,000 0,1137981 0,14300862 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,1137981 0,14293509 ! sex differentiation GO:0007548 171 96 1,000 0,11410403 0,1432457 ! transcription initiation GO:0006352 171 97 1,000 0,11606461 0,14563217 ! leukocyte differentiation GO:0002521 232 98 1,000 0,11803376 0,14802694 ! regulation of cell killing GO:0031341 46 21 0,000 0,11913667 0,14933344 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,11913667 0,14925686 ! hormone secretion GO:0046879 39 21 0,000 0,11913667 0,14918036 ! cAMP metabolic process GO:0046058 41 21 0,000 0,11913667 0,14910393 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,11913667 0,14902758 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,11913667 0,14895132 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,11913667 0,14887513 ! ovarian follicle development GO:0001541 39 21 0,000 0,11913667 0,14879901 ! smooth muscle contraction GO:0006939 48 21 0,000 0,11913667 0,14872298 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,11913667 0,14864702 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,11913667 0,14857114 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,11913667 0,14849534 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,11913667 0,14841962 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,11913667 0,14834397 ! sensory perception of pain GO:0019233 33 21 0,000 0,11913667 0,1482684 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,11913667 0,14819291 ! diencephalon development GO:0021536 36 21 0,000 0,11913667 0,14811749 ! collagen fibril organization GO:0030199 62 21 0,000 0,11913667 0,14804215 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,11913667 0,14796689 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,11913667 0,1478917 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,11913667 0,14781659 ! collagen catabolic process GO:0030574 29 21 0,000 0,11913667 0,14774156 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,11913667 0,1476666 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,11913667 0,14759172 ! actin filament-based movement GO:0030048 47 21 0,000 0,11913667 0,14751691 ! hormone metabolic process GO:0042445 171 100 1,000 0,12199711 0,15098224 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,12444322 0,15393154 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,12444322 0,15385364 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,12444322 0,15377582 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,12444322 0,15369807 ! microtubule-based transport GO:0010970 59 22 0,000 0,12444322 0,15362041 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,12444322 0,15354282 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,12444322 0,15346531 ! vacuolar transport GO:0007034 41 22 0,000 0,12444322 0,15338788 ! fucose metabolic process GO:0006004 44 22 0,000 0,12444322 0,15331053 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,12444322 0,15323326 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,12444322 0,15315606 ! stem cell differentiation GO:0048863 57 22 0,000 0,12444322 0,15307895 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,12444322 0,15300191 ! cytolysis GO:0019835 27 22 0,000 0,12444322 0,15292494 ! vasodilation GO:0042311 40 22 0,000 0,12444322 0,15284806 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,12444322 0,15277125 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,12444322 0,15269452 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,12444322 0,15261786 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,12444322 0,15254129 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,12444322 0,15246479 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,12444322 0,15238836 ! sarcomere organization GO:0045214 32 22 0,000 0,12444322 0,15231202 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,12444322 0,15223575 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,12444322 0,15215955 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,12444322 0,15208344 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,12444322 0,15200739 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,12444322 0,15193143 ! protein stabilization GO:0050821 41 22 0,000 0,12444322 0,15185554 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,12971796 0,15821316 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,12971796 0,15813421 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,12971796 0,15805534 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,12971796 0,15797655 ! gluconeogenesis GO:0006094 38 23 0,000 0,12971796 0,15789784 ! glycerol metabolic process GO:0006071 40 23 0,000 0,12971796 0,15781921 ! viral genome replication GO:0019079 44 23 0,000 0,12971796 0,15774065 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,12971796 0,15766217 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,12971796 0,15758377 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,12971796 0,15750545 ! regeneration GO:0031099 42 23 0,000 0,12971796 0,15742721 ! visual behavior GO:0007632 46 23 0,000 0,12971796 0,15734904 ! response to ethanol GO:0045471 47 23 0,000 0,12971796 0,15727095 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,12971796 0,15719294 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,12971796 0,15711501 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,12971796 0,15703715 ! peroxisome organization GO:0007031 43 23 0,000 0,12971796 0,15695937 ! lysosome organization GO:0007040 47 23 0,000 0,12971796 0,15688167 ! vesicle targeting GO:0006903 49 23 0,000 0,12971796 0,15680404 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,12971796 0,15672649 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,12971796 0,15664902 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,12971796 0,15657162 ! fatty acid transport GO:0015908 47 23 0,000 0,12971796 0,1564943 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,12971796 0,15641706 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,12971796 0,15633989 ! hormone transport GO:0009914 41 23 0,000 0,12971796 0,1562628 ! cell-cell recognition GO:0009988 28 23 0,000 0,12971796 0,15618579 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,12971796 0,15610885 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,12971796 0,15603199 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,12971796 0,1559552 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,13496106 0,16217898 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,13496106 0,16209925 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,13496106 0,16201959 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,13496106 0,16194002 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,13496106 0,16186052 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,13496106 0,1617811 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,13496106 0,16170175 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,13496106 0,16162249 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,13496106 0,1615433 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,13496106 0,16146419 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,13496106 0,16138516 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,13496106 0,1613062 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,13496106 0,16122732 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,13496106 0,16114852 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,13496106 0,1610698 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,13496106 0,16099115 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,13496106 0,16091258 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,13496106 0,16083408 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,13496106 0,16075567 ! membrane depolarization GO:0051899 45 24 0,000 0,13496106 0,16067733 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,13496106 0,16059906 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,13496106 0,16052087 ! platelet activation GO:0030168 41 24 0,000 0,13496106 0,16044276 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,13496106 0,16036472 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,13496106 0,16028676 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,13496106 0,16020888 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,13496106 0,16013107 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,13496106 0,16005334 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,13496106 0,15997568 ! regulation of amine transport GO:0051952 41 24 0,000 0,13496106 0,1598981 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,14017273 0,16599223 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,14017273 0,16591181 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,14017273 0,16583146 ! phototransduction GO:0007602 37 25 0,000 0,14017273 0,1657512 ! keratinization GO:0031424 37 25 0,000 0,14017273 0,16567101 ! vacuole organization GO:0007033 49 25 0,000 0,14017273 0,16559089 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,14017273 0,16551086 ! receptor metabolic process GO:0043112 53 25 0,000 0,14017273 0,1654309 ! chromosome condensation GO:0030261 48 25 0,000 0,14017273 0,16535102 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,14017273 0,16527122 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,14017273 0,1651915 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,14017273 0,16511185 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,14017273 0,16503227 ! immunoglobulin production GO:0002377 62 25 0,000 0,14017273 0,16495278 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,14017273 0,16487336 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,14017273 0,16479402 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,14017273 0,16471475 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,14535314 0,17072006 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,14535314 0,17063802 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,14535314 0,17055606 ! molting cycle process GO:0022404 52 26 0,000 0,14535314 0,17047418 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,14535314 0,17039238 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,14535314 0,17031065 GO:0006479|protein amino acid methylation, ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,14535314 0,17022901 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,14535314 0,17014744 ! digestive system process GO:0022600 49 26 0,000 0,14535314 0,17006596 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,14535314 0,16998455 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,14535314 0,16990321 ! osteoblast differentiation GO:0001649 63 26 0,000 0,14535314 0,16982196 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,14535314 0,16974078 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,14535314 0,16965968 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,14535314 0,16957866 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,14535314 0,16949772 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,14535314 0,16941685 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,14535314 0,16933606 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,14535314 0,16925535 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,14535314 0,16917471 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,14535314 0,16909415 ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,14535314 0,16901367 ! alditol metabolic process GO:0019400 44 26 0,000 0,14535314 0,16893326 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,14535314 0,16885293 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,15050248 0,17475169 ! embryonic pattern specification GO:0009880 49 27 0,000 0,15050248 0,17466868 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,15050248 0,17458574 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,15050248 0,17450288 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,15050248 0,1744201 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,15050248 0,17433739 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,15050248 0,17425477 ! iron ion transport GO:0006826 65 27 0,000 0,15050248 0,17417222 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,15050248 0,17408976 ! superoxide metabolic process GO:0006801 41 27 0,000 0,15050248 0,17400737 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,15050248 0,17392505 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,15050248 0,17384282 ! leukocyte proliferation GO:0070661 59 27 0,000 0,15050248 0,17376066 GO:0032943|mononuclear cell proliferation, ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,15562095 0,17958525 ! vesicle docking GO:0048278 55 28 0,000 0,15562095 0,17950046 ! circadian rhythm GO:0007623 56 28 0,000 0,15562095 0,17941575 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,15562095 0,17933112 ! fat cell differentiation GO:0045444 57 28 0,000 0,15562095 0,17924657 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,15562095 0,1791621 ! sperm motility GO:0030317 37 28 0,000 0,15562095 0,17907771 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,15562095 0,17899339 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,15562095 0,17890916 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,15562095 0,17882501 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,15562095 0,17874094 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,15562095 0,17865694 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,15562095 0,17857303 ! glutathione metabolic process GO:0006749 42 28 0,000 0,15562095 0,17848919 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,15562095 0,17840543 ! lipid oxidation GO:0034440 48 28 0,000 0,15562095 0,17832175 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,15562095 0,17823815 ! translational initiation GO:0006413 66 29 0,000 0,16070871 0,18397909 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,16070871 0,18389292 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,16070871 0,18380683 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,16070871 0,18372082 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,16070871 0,18363489 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,16070871 0,18354903 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,16070871 0,18346326 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,16070871 0,18337757 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,16070871 0,18329196 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,16070871 0,18320643 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,16576597 0,18888351 ! phenol metabolic process GO:0018958 56 30 0,000 0,16576597 0,18879546 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,16576597 0,18870748 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,16576597 0,18861959 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,16576597 0,18853178 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,16576597 0,18844405 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,16576597 0,1883564 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,16576597 0,18826883 ! acute-phase response GO:0006953 50 30 0,000 0,16576597 0,18818134 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,16576597 0,18809394 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,16576597 0,18800662 ! myofibril assembly GO:0030239 50 30 0,000 0,16576597 0,18791938 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,16576597 0,18783221 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,16576597 0,18774513 ! cell fate determination GO:0001709 64 30 0,000 0,16576597 0,18765813 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,16576597 0,18757122 ! phospholipid transport GO:0015914 65 30 0,000 0,16576597 0,18748438 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,16576597 0,18739762 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,16576597 0,18731094 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,16576597 0,18722434 ! regulation of coagulation GO:0050818 52 30 0,000 0,16576597 0,18713783 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,17079289 0,1927238 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,17079289 0,19263482 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,17079289 0,19254593 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,17079289 0,19245711 ! regulation of innate immune response GO:0045088 57 31 0,000 0,17079289 0,19236838 ! ovulation cycle process GO:0022602 55 31 0,000 0,17079289 0,19227973 ! peptide transport GO:0015833 60 31 0,000 0,17079289 0,19219117 ! male gonad development GO:0008584 56 31 0,000 0,17079289 0,19210268 ! detection of light stimulus GO:0009583 44 31 0,000 0,17079289 0,19201428 ! natural killer cell activation GO:0030101 50 31 0,000 0,17079289 0,19192595 ! cofactor catabolic process GO:0051187 54 31 0,000 0,17079289 0,19183771 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,17079289 0,19174955 ! response to heat GO:0009408 54 31 0,000 0,17079289 0,19166147 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,17079289 0,19157347 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,17578966 0,19708772 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,17578966 0,19699731 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,17578966 0,19690698 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,17578966 0,19681674 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,17578966 0,19672658 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,17578966 0,19663651 ! muscle cell development GO:0055001 52 32 0,000 0,17578966 0,19654651 ! mesoderm formation GO:0001707 73 32 0,000 0,17578966 0,1964566 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,17578966 0,19636677 ! ovulation cycle GO:0042698 57 32 0,000 0,17578966 0,19627703 ! BMP signaling pathway GO:0030509 71 32 0,000 0,17578966 0,19618736 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,17578966 0,19609778 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,17578966 0,19600828 ! gene silencing GO:0016458 71 32 0,000 0,17578966 0,19591886 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,18075646 0,20136253 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,18075646 0,20127075 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,18075646 0,20117906 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,18075646 0,20108744 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,18075646 0,20099592 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,18075646 0,20090447 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,18075646 0,20081311 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,18075646 0,20072183 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,18075646 0,20063063 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,18075646 0,20053952 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,18569347 0,20592335 ! post-embryonic development GO:0009791 76 34 0,000 0,18569347 0,20582992 ! cholesterol transport GO:0030301 62 34 0,000 0,18569347 0,20573657 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,18569347 0,20564331 ! spliceosome assembly GO:0000245 75 34 0,000 0,18569347 0,20555013 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,18569347 0,20545704 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,18569347 0,20536403 ! formation of primary germ layer GO:0001704 76 34 0,000 0,18569347 0,2052711 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,18569347 0,20517826 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,18569347 0,20508551 ! adult locomotory behavior GO:0008344 62 34 0,000 0,18569347 0,20499283 ! negative regulation of secretion GO:0051048 68 35 0,000 0,19060086 0,21031522 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,19060086 0,21022027 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,19060086 0,21012541 ! membrane docking GO:0022406 69 35 0,000 0,19060086 0,21003063 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,19060086 0,20993594 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,19060086 0,20984133 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,19060086 0,2097468 ! ceramide metabolic process GO:0006672 72 35 0,000 0,19060086 0,20965237 ! sterol transport GO:0015918 63 35 0,000 0,19060086 0,20955801 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,19060086 0,20946374 ! vesicle localization GO:0051648 70 35 0,000 0,19060086 0,20936956 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,19547882 0,21463135 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,19547882 0,21453493 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,19547882 0,2144386 ! protein targeting to membrane GO:0006612 75 36 0,000 0,19547882 0,21434235 ! regulation of proteolysis GO:0030162 77 36 0,000 0,19547882 0,21424619 ! aerobic respiration GO:0009060 56 36 0,000 0,19547882 0,21415012 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,19547882 0,21405413 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,19547882 0,21395822 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,20032752 0,2191671 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,20032752 0,21906899 ! actomyosin structure organization GO:0031032 68 37 0,000 0,20032752 0,21897097 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,20032752 0,21887304 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,20514713 0,22403864 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,20514713 0,22393853 ! organic anion transport GO:0015711 82 38 0,000 0,20514713 0,22383851 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,20514713 0,22373859 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,20514713 0,22363875 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,20514713 0,223539 ! spermatid development GO:0007286 69 38 0,000 0,20514713 0,22343934 ! pigment metabolic process GO:0042440 87 38 0,000 0,20514713 0,22333976 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,20993783 0,2284535 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,20993783 0,22835178 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,20993783 0,22825016 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,20993783 0,22814862 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,20993783 0,22804718 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,20993783 0,22794583 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,21469978 0,23301269 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,21469978 0,23290922 ! learning GO:0007612 82 40 0,000 0,21469978 0,23280585 ! lipid homeostasis GO:0055088 75 40 0,000 0,21469978 0,23270256 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,21469978 0,23259937 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,21469978 0,23249626 ! mRNA catabolic process GO:0006402 79 41 0,000 0,21943317 0,23751672 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,21943317 0,23741153 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,21943317 0,23730644 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,21943317 0,23720143 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,21943317 0,23709652 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,21943317 0,23699171 ! feeding behavior GO:0007631 69 41 0,000 0,21943317 0,23688698 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,21943317 0,23678235 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,21943317 0,23667781 ! RNA modification GO:0009451 64 41 0,000 0,21943317 0,23657336 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,22413816 0,24153927 ! organic ether metabolic process GO:0018904 59 42 0,000 0,22413816 0,24143277 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,22413816 0,24132637 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,22413816 0,24122006 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,22413816 0,24111384 ! regulation of protein secretion GO:0050708 77 42 0,000 0,22413816 0,24100772 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,22413816 0,24090169 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,22881493 0,24582008 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,22881493 0,24571203 ! regulation of tube size GO:0035150 76 43 0,000 0,22881493 0,24560407 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,22881493 0,24549621 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,22881493 0,24538844 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,22881493 0,24528077 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,22881493 0,24517319 ! ion transmembrane transport GO:0034220 79 43 0,000 0,22881493 0,2450657 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,23346363 0,24993499 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,23346363 0,24982551 ! striated muscle contraction GO:0006941 85 44 0,000 0,23346363 0,24971613 ! phagocytosis GO:0006909 105 44 0,000 0,23346363 0,24960685 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,23346363 0,24949766 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,23808444 0,25432457 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,23808444 0,25421341 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,23808444 0,25410235 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,23808444 0,25399139 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,23808444 0,25388053 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,24267752 0,25866544 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,24267752 0,25855264 ! leukocyte migration GO:0050900 75 46 0,000 0,24267752 0,25843993 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,24267752 0,25832732 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,24267752 0,25821481 ! pigmentation GO:0043473 103 46 0,000 0,24267752 0,25810239 ! cell growth GO:0016049 90 46 0,000 0,24267752 0,25799008 ! positive regulation of defense response GO:0031349 88 48 0,000 0,25178118 0,26755173 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,25178118 0,2674354 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,25178118 0,26731917 ! endosome transport GO:0016197 127 48 0,000 0,25178118 0,26720305 ! male sex differentiation GO:0046661 93 48 0,000 0,25178118 0,26708703 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,25178118 0,2669711 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,25178118 0,26685528 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,25178118 0,26673956 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,25629208 0,27140076 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,25629208 0,27128316 ! regulation of ion transport GO:0043269 86 50 0,000 0,26077591 0,27590972 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,26077591 0,27579028 ! regulation of ossification GO:0030278 123 50 0,000 0,26077591 0,27567094 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,26077591 0,2755517 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,26077591 0,27543257 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,26077591 0,27531354 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,26523283 0,27989797 ! response to temperature stimulus GO:0009266 84 51 0,000 0,26523283 0,27977711 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,26523283 0,27965636 ! Notch signaling pathway GO:0007219 111 52 0,000 0,269663 0,28420479 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,269663 0,28408224 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,269663 0,28395979 ! excretion GO:0007588 87 52 0,000 0,269663 0,28383745 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,269663 0,28371521 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,27406659 0,28822414 ! positive regulation of growth GO:0045927 96 53 0,000 0,27406659 0,28810012 ! chromatin remodeling GO:0006338 122 53 0,000 0,27406659 0,2879762 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,27406659 0,2878524 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,27406659 0,2877287 ! vesicle organization GO:0016050 127 53 0,000 0,27406659 0,2876051 ! regulation of translational initiation GO:0006446 87 54 0,000 0,27844375 0,29207302 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,27844375 0,29194767 ! neuromuscular process GO:0050905 107 54 0,000 0,27844375 0,29182243 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,27844375 0,29169729 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,27844375 0,29157226 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,27844375 0,29144733 ! RNA catabolic process GO:0006401 103 55 0,000 0,28279464 0,29587464 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,28279464 0,29574799 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,28279464 0,29562144 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,28279464 0,29549499 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,28279464 0,29536866 ! chloride transport GO:0006821 102 57 0,000 0,29141823 0,30424561 ! regulation of actin filament length GO:0030832 118 58 0,000 0,29569124 0,30857484 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,29569124 0,30844309 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,29569124 0,30831144 ! gastrulation GO:0007369 122 58 0,000 0,29569124 0,30817991 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,29569124 0,30804849 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,30416048 0,3167366 ! regulation of endocytosis GO:0030100 104 60 0,000 0,30416048 0,31660165 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,30416048 0,31646681 ! adult behavior GO:0030534 104 60 0,000 0,30416048 0,31633208 ! positive regulation of secretion GO:0051047 110 61 0,000 0,30835701 0,32056008 ! regulation of cellular component size GO:0032535 125 61 0,000 0,30835701 0,32042373 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,30835701 0,32028749 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,30835701 0,32015137 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,30835701 0,32001537 ! regulation of heart contraction GO:0008016 123 61 0,000 0,30835701 0,31987948 ! proton transport GO:0015992 117 61 0,000 0,30835701 0,31974371 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,30835701 0,31960805 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,31252835 0,32379422 ! tRNA processing GO:0008033 102 62 0,000 0,31252835 0,32365696 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,31667465 0,32781194 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,31667465 0,32767309 ! hydrogen transport GO:0006818 121 64 0,000 0,32079606 0,33179711 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,32079606 0,33165669 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,32489272 0,33574996 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,32489272 0,335608 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,32489272 0,33546615 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,32489272 0,33532443 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,32489272 0,33518282 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,32896479 0,3392406 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,33301241 0,34326976 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,33703573 0,34727047 ! detection of external stimulus GO:0009581 102 68 0,000 0,33703573 0,34712407 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,33703573 0,34697779 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,3410349 0,35094703 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,3410349 0,35079926 ! cell redox homeostasis GO:0045454 114 70 0,000 0,34501005 0,35473887 ! activation of immune response GO:0002253 120 70 0,000 0,34501005 0,35458963 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,34896133 0,35849981 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,34896133 0,35834911 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,35288889 0,36223007 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,35288889 0,36207793 ! humoral immune response GO:0006959 115 73 0,000 0,35679287 0,36592988 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,35679287 0,36577632 ! regulation of immune effector process GO:0002697 156 73 0,000 0,35679287 0,36562289 ! acute inflammatory response GO:0002526 118 74 0,000 0,3606734 0,36944449 ! amino acid transport GO:0006865 148 74 0,000 0,3606734 0,36928965 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,3606734 0,36913494 ! transition metal ion transport GO:0000041 143 75 0,000 0,36453063 0,37292643 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,36453063 0,37277033 ! rhythmic process GO:0048511 142 75 0,000 0,36453063 0,37261436 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,36836469 0,37637597 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,36836469 0,37621862 ! amine catabolic process GO:0009310 136 77 0,000 0,37217573 0,37995207 ! neurotransmitter transport GO:0006836 142 77 0,000 0,37217573 0,37979336 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,37217573 0,37963478 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,37217573 0,37947634 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,37596388 0,38317888 ! antigen processing and presentation GO:0019882 117 78 0,000 0,37596388 0,38301908 ! blood coagulation GO:0007596 151 79 0,000 0,37972928 0,38669389 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,37972928 0,38653277 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,37972928 0,38637178 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,37972928 0,38621092 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,38347207 0,38985529 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,38347207 0,38969312 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,39456609 0,4008004 ! exocytosis GO:0006887 153 83 0,000 0,39456609 0,40063382 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,39456609 0,40046737 ! inorganic anion transport GO:0015698 156 83 0,000 0,39456609 0,40030106 ! digestion GO:0007586 130 84 0,000 0,39821976 0,40384013 ! hemostasis GO:0007599 165 85 0,000 0,40185149 0,40735402 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,40185149 0,40718506 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,40185149 0,40701625 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,40185149 0,40684757 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,4054614 0,41033231 ! regulation of lyase activity GO:0051339 169 86 0,000 0,4054614 0,4101624 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,40904962 0,41362095 ! nucleosome assembly GO:0006334 126 87 0,000 0,40904962 0,41344982 ! cellular respiration GO:0045333 143 88 0,000 0,41261629 0,41688238 ! amine biosynthetic process GO:0009309 146 88 0,000 0,41261629 0,41671004 ! sensory perception of smell GO:0007608 117 88 0,000 0,41261629 0,41653785 ! chromatin assembly GO:0031497 128 88 0,000 0,41261629 0,4163658 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,41616153 0,41976987 ! cellular defense response GO:0006968 123 89 0,000 0,41616153 0,41959663 ! regulation of neurological system process GO:0031644 175 89 0,000 0,41616153 0,41942352 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,41968548 0,42280067 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,41968548 0,42262639 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,42318825 0,42597812 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,42318825 0,42580267 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,42666998 0,42912917 ! amine transport GO:0015837 181 93 0,000 0,43013079 0,4324319 ! vitamin metabolic process GO:0006766 153 93 0,000 0,43013079 0,43225402 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,4335708 0,43553186 ! sterol metabolic process GO:0016125 166 94 0,000 0,4335708 0,43535285 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,4335708 0,43517398 ! regulation of defense response GO:0031347 171 95 0,000 0,43699015 0,43842585 ! nucleosome organization GO:0034728 143 95 0,000 0,43699015 0,43824587 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,43699015 0,43806604 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,43699015 0,43788636 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,43699015 0,43770682 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,43699015 0,43752743 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,44376733 0,44413093 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,44712541 0,44730851 ! positive regulation of immune response GO:0050778 175 100 0,000 0,45378115 0,45378115