pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6578-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! mitotic sister chromatid segregation GO:0000070 63 36 5,000 3,561E-08 8,698E-05 ! sister chromatid segregation GO:0000819 65 37 5,000 4,231E-08 5,168E-05 ! chromosome segregation GO:0007059 127 67 6,000 7,141E-08 5,815E-05 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 6,000 7,141E-08 4,362E-05 ! negative regulation of ligase activity GO:0051352 116 68 6,000 7,925E-08 3,872E-05 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 6,000 7,925E-08 3,227E-05 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 6,000 1,183E-07 4,128E-05 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 6,000 2,256E-07 6,889E-05 ! regulation of ligase activity GO:0051340 147 84 6,000 3,447E-07 9,356E-05 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 6,000 6,925E-07 1,692E-04 GO:0010498|proteasomal protein catabolic process, ! spindle organization GO:0007051 50 32 4,000 7,225E-07 1,605E-04 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 5,000 1,895E-06 3,857E-04 ! carbohydrate homeostasis GO:0033500 59 39 4,000 2,004E-06 3,766E-04 GO:0042593|glucose homeostasis, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 5,000 2,437E-06 4,252E-04 ! mitotic chromosome condensation GO:0007076 37 19 3,000 2,82E-06 4,592E-04 ! myoblast cell fate commitment GO:0048625 18 6 2,000 2,925E-06 4,466E-04 ! positive regulation of ligase activity GO:0051351 130 77 5,000 3,617E-06 5,198E-04 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 5,000 4,525E-06 6,141E-04 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 3,000 5,256E-06 6,758E-04 ! positive regulation of cell cycle GO:0045787 96 48 4,000 5,734E-06 7,004E-04 ! positive regulation of insulin secretion GO:0032024 17 8 2,000 8,126E-06 9,453E-04 ! chromosome condensation GO:0030261 48 25 3,000 8,976E-06 9,967E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 1,214E-05 1,29E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 2,000 1,214E-05 1,236E-03 ! SMAD protein nuclear translocation GO:0007184 21 10 2,000 1,728E-05 1,688E-03 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 2,000 1,728E-05 1,623E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 2,000 2,366E-05 2,141E-03 ! positive regulation of peptide secretion GO:0002793 24 11 2,000 2,366E-05 2,064E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 2,000 3,142E-05 2,647E-03 ! mitotic spindle organization GO:0007052 23 12 2,000 3,142E-05 2,559E-03 ! regulation of hormone metabolic process GO:0032350 28 12 2,000 3,142E-05 2,476E-03 ! activation of protein kinase activity GO:0032147 170 80 4,000 7,016E-05 5,356E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 7,874E-05 5,829E-03 ! response to drug GO:0042493 149 83 4,000 8,365E-05 6,01E-03 ! negative regulation of cell cycle process GO:0010948 35 17 2,000 9,524E-05 6,648E-03 ! myoblast differentiation GO:0045445 50 17 2,000 9,524E-05 6,463E-03 ! branching morphogenesis of a tube GO:0048754 102 45 3,000 9,729E-05 6,424E-03 ! patterning of blood vessels GO:0001569 43 18 2,000 1,138E-04 7,319E-03 ! epidermis morphogenesis GO:0048730 43 18 2,000 1,138E-04 7,131E-03 ! detection of bacterium GO:0016045 22 18 2,000 1,138E-04 6,953E-03 ! regulation of cell cycle process GO:0010564 161 90 4,000 1,229E-04 7,322E-03 ! positive regulation of hormone secretion GO:0046887 35 19 2,000 1,347E-04 7,833E-03 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 2,000 1,347E-04 7,651E-03 ! protein export from nucleus GO:0006611 40 19 2,000 1,347E-04 7,477E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 1,578E-04 8,567E-03 ! pancreas development GO:0031016 40 20 2,000 1,578E-04 8,381E-03 ! actin filament bundle formation GO:0051017 47 20 2,000 1,578E-04 8,203E-03 ! morphogenesis of a branching structure GO:0001763 116 52 3,000 1,717E-04 8,74E-03 ! phosphatidylinositol metabolic process GO:0046488 47 21 2,000 1,834E-04 9,143E-03 ! collagen fibril organization GO:0030199 62 21 2,000 1,834E-04 8,96E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 2,115E-04 0,01013193 ! calcium-independent cell-cell adhesion GO:0016338 36 24 2,000 2,758E-04 0,01295833 ! detection of biotic stimulus GO:0009595 34 24 2,000 2,758E-04 0,01271383 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 2,783E-04 0,01259079 ! serotonin receptor signaling pathway GO:0007210 10 5 1,000 2,783E-04 0,01236186 ! response to protozoan GO:0001562 13 5 1,000 2,783E-04 0,01214112 ! positive regulation of neurotransmitter secretion GO:0001956 11 5 1,000 2,783E-04 0,01192811 ! smooth muscle tissue development GO:0048745 32 5 1,000 2,783E-04 0,01172246 ! valine metabolic process GO:0006573 12 5 1,000 2,783E-04 0,01152377 ! polyol catabolic process GO:0046174 9 5 1,000 2,783E-04 0,01133171 GO:0019405|alditol catabolic process, ! sister chromatid cohesion GO:0007062 15 5 1,000 2,783E-04 0,01114594 ! positive regulation of transporter activity GO:0032411 8 5 1,000 2,783E-04 0,01096617 GO:0032414|positive regulation of ion transmembrane transporter activity, ! positive regulation of vasoconstriction GO:0045907 10 5 1,000 2,783E-04 0,0107921 ! cellular glucose homeostasis GO:0001678 6 5 1,000 2,783E-04 0,01062348 ! regulation of centrosome cycle GO:0046605 7 5 1,000 2,783E-04 0,01046004 ! meiotic chromosome segregation GO:0045132 10 5 1,000 2,783E-04 0,01030155 ! muscle cell proliferation GO:0033002 12 5 1,000 2,783E-04 0,0101478 ! regulation of hair follicle development GO:0051797 10 5 1,000 2,783E-04 9,999E-03 GO:0042634|regulation of hair cycle, ! secretory granule organization GO:0033363 15 5 1,000 2,783E-04 9,854E-03 ! glial cell migration GO:0008347 10 5 1,000 2,783E-04 9,713E-03 ! regulation of sensory perception GO:0051931 8 5 1,000 2,783E-04 9,576E-03 GO:0051930|regulation of sensory perception of pain, ! stem cell division GO:0017145 11 5 1,000 2,783E-04 9,443E-03 GO:0048103|somatic stem cell division, ! organ regeneration GO:0031100 7 5 1,000 2,783E-04 9,314E-03 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 3,122E-04 0,01030715 ! regulation of transmembrane transport GO:0034762 39 25 2,000 3,122E-04 0,01016972 ! vasculogenesis GO:0001570 49 25 2,000 3,122E-04 0,01003591 ! regulation of insulin secretion GO:0050796 42 25 2,000 3,122E-04 9,906E-03 ! positive regulation of secretion GO:0051047 110 61 3,000 3,189E-04 9,989E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 3,516E-04 0,01087151 ! regulation of mitosis GO:0007088 112 63 3,000 3,61E-04 0,01102479 GO:0051783|regulation of nuclear division, ! positive regulation of cell motion GO:0051272 157 65 3,000 4,07E-04 0,01227429 ! embryonic hemopoiesis GO:0035162 16 6 1,000 4,16E-04 0,01239367 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 1,000 4,16E-04 0,01224435 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! early endosome to late endosome transport GO:0045022 16 6 1,000 4,16E-04 0,01209858 ! establishment of spindle localization GO:0051293 16 6 1,000 4,16E-04 0,01195625 GO:0051653|spindle localization, ! neural tube patterning GO:0021532 8 6 1,000 4,16E-04 0,01181722 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 4,16E-04 0,01168139 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 1,000 4,16E-04 0,01154865 ! fat cell differentiation GO:0045444 57 28 2,000 4,395E-04 0,01206428 ! regulation of peptide secretion GO:0002791 52 29 2,000 4,883E-04 0,01325488 ! cell cycle checkpoint GO:0000075 145 71 3,000 5,697E-04 0,01529549 ! prostate gland development GO:0030850 14 7 1,000 5,804E-04 0,01541099 ! SMAD protein complex assembly GO:0007183 13 7 1,000 5,804E-04 0,01524528 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 5,804E-04 0,0150831 ! positive regulation of neurotransmitter transport GO:0051590 16 7 1,000 5,804E-04 0,01492433 ! regulation of dopamine metabolic process GO:0042053 12 7 1,000 5,804E-04 0,01476887 GO:0042069|regulation of catecholamine metabolic process, ! melanosome organization GO:0032438 10 7 1,000 5,804E-04 0,01461661 ! spindle checkpoint GO:0031577 16 7 1,000 5,804E-04 0,01446746 ! negative regulation of nuclear division GO:0051784 15 7 1,000 5,804E-04 0,01432133 GO:0045839|negative regulation of mitosis, ! dopamine biosynthetic process GO:0042416 18 7 1,000 5,804E-04 0,01417811 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 6,551E-04 0,01584601 ! myeloid leukocyte activation GO:0002274 53 32 2,000 6,551E-04 0,01569066 ! regulation of caspase activity GO:0043281 136 74 3,000 6,664E-04 0,01580591 ! leukocyte chemotaxis GO:0030595 55 33 2,000 7,178E-04 0,01686183 GO:0060326|cell chemotaxis, ! glycerol-3-phosphate metabolic process GO:0006072 15 8 1,000 7,711E-04 0,01794093 ! regulation of cellular amine metabolic process GO:0033238 13 8 1,000 7,711E-04 0,01777168 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 7,711E-04 0,01760559 ! succinate metabolic process GO:0006105 17 8 1,000 7,711E-04 0,01744258 ! endothelial cell differentiation GO:0045446 17 8 1,000 7,711E-04 0,01728255 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 7,711E-04 0,01712544 ! pigment granule organization GO:0048753 17 8 1,000 7,711E-04 0,01697115 ! regulation of defense response to virus by virus GO:0050690 22 8 1,000 7,711E-04 0,01681963 ! macrophage activation GO:0042116 13 8 1,000 7,711E-04 0,01667078 ! protein retention in ER lumen GO:0006621 14 8 1,000 7,711E-04 0,01652455 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 7,711E-04 0,01638085 ! positive regulation of epidermis development GO:0045684 13 8 1,000 7,711E-04 0,01623964 ! behavioral response to nicotine GO:0035095 12 8 1,000 7,711E-04 0,01610084 ! regulation of endopeptidase activity GO:0052548 141 77 3,000 7,741E-04 0,01602694 ! steroid biosynthetic process GO:0006694 146 79 3,000 8,524E-04 0,01749974 ! negative regulation of organelle organization GO:0010639 181 80 3,000 8,936E-04 0,0181921 ! response to hypoxia GO:0001666 178 81 3,000 9,361E-04 0,0189009 ! regulation of peptidase activity GO:0052547 150 82 3,000 9,801E-04 0,01962623 ! protein import into nucleus GO:0006606 174 82 3,000 9,801E-04 0,01946667 ! artery development GO:0060840 25 9 1,000 9,879E-04 0,01946413 GO:0048844|artery morphogenesis, ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 1,000 9,879E-04 0,01930842 ! glycine catabolic process GO:0006546 15 9 1,000 9,879E-04 0,01915518 ! pyrimidine base metabolic process GO:0006206 22 9 1,000 9,879E-04 0,01900435 ! regulation of amino acid transport GO:0051955 12 9 1,000 9,879E-04 0,01885588 ! response to oxygen levels GO:0070482 183 83 3,000 1,025E-03 0,01942084 ! nuclear import GO:0051170 177 83 3,000 1,025E-03 0,01927145 ! mitotic cell cycle checkpoint GO:0007093 76 39 2,000 1,175E-03 0,02190407 ! regulation of phosphatase activity GO:0010921 28 10 1,000 1,231E-03 0,02277567 ! positive regulation of heart contraction GO:0045823 17 10 1,000 1,231E-03 0,02260443 ! phosphagen metabolic process GO:0006599 17 10 1,000 1,231E-03 0,02243574 GO:0006600|creatine metabolic process, ! nucleobase biosynthetic process GO:0046112 26 10 1,000 1,231E-03 0,02226955 ! epithelial cell development GO:0002064 21 10 1,000 1,231E-03 0,0221058 ! salivary gland development GO:0007431 28 10 1,000 1,231E-03 0,02194445 ! midbrain development GO:0030901 14 10 1,000 1,231E-03 0,02178543 ! serine family amino acid catabolic process GO:0009071 18 10 1,000 1,231E-03 0,0216287 ! natural killer cell mediated immunity GO:0002228 19 10 1,000 1,231E-03 0,02147421 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 1,000 1,231E-03 0,02132191 ! response to nicotine GO:0035094 20 10 1,000 1,231E-03 0,02117175 ! tube morphogenesis GO:0035239 194 89 3,000 1,329E-03 0,02270971 ! protein localization in nucleus GO:0034504 192 89 3,000 1,329E-03 0,022552 ! regulation of hormone secretion GO:0046883 69 41 2,000 1,359E-03 0,02290347 ! gland development GO:0048732 220 91 3,000 1,443E-03 0,02414824 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,458E-03 0,02423508 ! DNA methylation GO:0006306 19 11 1,000 1,499E-03 0,02474075 GO:0006305|DNA alkylation, ! thymus development GO:0048538 29 11 1,000 1,499E-03 0,0245747 ! regulation of organic acid transport GO:0032890 19 11 1,000 1,499E-03 0,02441087 ! regulation of embryonic development GO:0045995 35 11 1,000 1,499E-03 0,02424921 ! epithelial cell differentiation GO:0030855 83 43 2,000 1,562E-03 0,02509777 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 2,000 1,562E-03 0,02493373 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 2,000 1,669E-03 0,02648107 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 1,782E-03 0,02808 ! virus-host interaction GO:0019048 30 12 1,000 1,792E-03 0,02806796 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 1,000 1,792E-03 0,02788919 ! focal adhesion formation GO:0048041 37 12 1,000 1,792E-03 0,02771267 ! T cell homeostasis GO:0043029 28 12 1,000 1,792E-03 0,02753838 ! leukocyte mediated cytotoxicity GO:0001909 28 12 1,000 1,792E-03 0,02736627 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,898E-03 0,02880726 ! leukocyte migration GO:0050900 75 46 2,000 1,898E-03 0,02862944 ! pigmentation GO:0043473 103 46 2,000 1,898E-03 0,0284538 ! positive regulation of protein transport GO:0051222 80 46 2,000 1,898E-03 0,0282803 ! positive regulation of cell growth GO:0030307 24 13 1,000 2,111E-03 0,03125235 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 1,000 2,111E-03 0,03106408 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 2,111E-03 0,03087807 ! exocrine system development GO:0035272 34 13 1,000 2,111E-03 0,03069427 ! L-glutamate transport GO:0015813 30 13 1,000 2,111E-03 0,03051265 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 2,111E-03 0,03033316 ! gland morphogenesis GO:0022612 31 13 1,000 2,111E-03 0,03015578 ! regulation of epidermis development GO:0045682 19 13 1,000 2,111E-03 0,02998045 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 1,000 2,111E-03 0,02980715 ! activation of caspase activity GO:0006919 95 50 2,000 2,413E-03 0,03388487 ! hair follicle morphogenesis GO:0031069 27 14 1,000 2,454E-03 0,03425756 ! palate development GO:0060021 32 14 1,000 2,454E-03 0,03406291 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 1,000 2,454E-03 0,03387047 ! catecholamine biosynthetic process GO:0042423 30 14 1,000 2,454E-03 0,03368019 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 1,000 2,822E-03 0,03850978 ! dopamine metabolic process GO:0042417 35 15 1,000 2,822E-03 0,03829584 ! cell killing GO:0001906 32 15 1,000 2,822E-03 0,03808426 ! lymphocyte homeostasis GO:0002260 33 15 1,000 2,822E-03 0,03787501 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 2,822E-03 0,03766804 ! positive regulation of growth GO:0045927 96 53 2,000 2,851E-03 0,03785438 ! negative regulation of cell motion GO:0051271 142 55 2,000 3,168E-03 0,04183809 ! positive regulation of cell size GO:0045793 29 16 1,000 3,213E-03 0,04220709 ! regulation of neurotransmitter secretion GO:0046928 35 16 1,000 3,213E-03 0,04198139 ! regulation of transmembrane transporter activity GO:0022898 27 16 1,000 3,213E-03 0,04175808 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 1,000 3,213E-03 0,04153714 ! regulation of dephosphorylation GO:0035303 43 16 1,000 3,213E-03 0,04131852 ! negative regulation of immune response GO:0050777 38 16 1,000 3,213E-03 0,0411022 ! neuron recognition GO:0008038 40 16 1,000 3,213E-03 0,04088812 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,213E-03 0,04067627 ! skeletal muscle fiber development GO:0048741 130 56 2,000 3,335E-03 0,04199213 ! positive regulation of caspase activity GO:0043280 108 57 2,000 3,506E-03 0,0439269 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 2,000 3,506E-03 0,04370279 ! heart morphogenesis GO:0003007 105 57 2,000 3,506E-03 0,04348094 ! regulation of intracellular transport GO:0032386 108 57 2,000 3,506E-03 0,04326134 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 3,629E-03 0,04455393 ! neutrophil chemotaxis GO:0030593 29 17 1,000 3,629E-03 0,04433116 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 1,000 3,629E-03 0,04411061 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 3,629E-03 0,04389224 ! induction of apoptosis via death domain receptors GO:0008625 23 17 1,000 3,629E-03 0,04367602 ! nucleobase metabolic process GO:0009112 43 17 1,000 3,629E-03 0,04346192 ! positive regulation of cell migration GO:0030335 137 58 2,000 3,683E-03 0,04389262 ! positive regulation of organelle organization GO:0010638 108 58 2,000 3,683E-03 0,04367955 ! nuclear export GO:0051168 110 59 2,000 3,865E-03 0,04561989 ! heart looping GO:0001947 34 18 1,000 4,069E-03 0,04778724 ! regulation of defense response to virus GO:0050688 35 18 1,000 4,069E-03 0,04755859 ! glycine metabolic process GO:0006544 30 18 1,000 4,069E-03 0,04733212 ! cell-substrate junction assembly GO:0007044 56 18 1,000 4,069E-03 0,0471078 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 1,000 4,069E-03 0,04688559 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 1,000 4,069E-03 0,04666547 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 1,000 4,069E-03 0,04644741 ! regulation of BMP signaling pathway GO:0030510 33 18 1,000 4,069E-03 0,04623137 ! defense response to virus GO:0051607 43 18 1,000 4,069E-03 0,04601734 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 1,000 4,531E-03 0,05101578 ! cellular pigmentation GO:0033059 37 19 1,000 4,531E-03 0,05078176 ! proximal/distal pattern formation GO:0009954 33 19 1,000 4,531E-03 0,05054988 ! protein import into nucleus, docking GO:0000059 42 20 1,000 5,017E-03 0,05571652 ! positive regulation of ossification GO:0045778 50 20 1,000 5,017E-03 0,05546441 ! skin development GO:0043588 42 20 1,000 5,017E-03 0,05521457 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 1,000 5,017E-03 0,05496697 ! forelimb morphogenesis GO:0035136 35 20 1,000 5,017E-03 0,05472159 ! response to alkaloid GO:0043279 38 20 1,000 5,017E-03 0,05447838 ! negative regulation of cell growth GO:0030308 142 67 2,000 5,522E-03 0,0596941 ! regulation of neurotransmitter transport GO:0051588 44 21 1,000 5,526E-03 0,05947468 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 5,526E-03 0,05921383 ! regulation of vasoconstriction GO:0019229 40 21 1,000 5,526E-03 0,05895525 ! extracellular matrix organization GO:0030198 146 68 2,000 5,755E-03 0,06112612 ! detection of external stimulus GO:0009581 102 68 2,000 5,755E-03 0,0608615 ! negative regulation of cell size GO:0045792 144 69 2,000 5,993E-03 0,06310903 ! positive regulation of bone remodeling GO:0046852 54 22 1,000 6,058E-03 0,06351569 GO:0034105|positive regulation of tissue remodeling, ! inactivation of MAPK activity GO:0000188 45 22 1,000 6,058E-03 0,06324425 ! cellular response to starvation GO:0009267 37 22 1,000 6,058E-03 0,06297513 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 6,058E-03 0,06270829 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 1,000 6,058E-03 0,06244369 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 6,612E-03 0,0678665 ! gluconeogenesis GO:0006094 38 23 1,000 6,612E-03 0,06758254 ! glycerol metabolic process GO:0006071 40 23 1,000 6,612E-03 0,06730094 ! regeneration GO:0031099 42 23 1,000 6,612E-03 0,06702168 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 6,612E-03 0,06674474 ! DNA modification GO:0006304 36 23 1,000 6,612E-03 0,06647007 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 6,612E-03 0,06619765 ! actin filament organization GO:0007015 167 72 2,000 6,743E-03 0,06724053 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 7,188E-03 0,07137948 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 7,188E-03 0,0710905 ! barbed-end actin filament capping GO:0051016 58 24 1,000 7,188E-03 0,07080384 GO:0051693|actin filament capping, ! negative regulation of phosphorylation GO:0042326 52 24 1,000 7,188E-03 0,07051949 ! pyrimidine nucleoside metabolic process GO:0006213 34 24 1,000 7,188E-03 0,07023741 ! regulation of amine transport GO:0051952 41 24 1,000 7,188E-03 0,06995758 ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 7,785E-03 0,07547591 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 7,785E-03 0,07517758 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 7,785E-03 0,07488161 ! interaction with host GO:0051701 66 25 1,000 7,785E-03 0,07458795 ! leukocyte homeostasis GO:0001776 50 25 1,000 7,785E-03 0,0742966 ! phosphoinositide metabolic process GO:0030384 146 77 2,000 8,113E-03 0,07711739 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 8,405E-03 0,07958663 ! pyruvate metabolic process GO:0006090 43 26 1,000 8,405E-03 0,07927935 ! molting cycle process GO:0022404 52 26 1,000 8,405E-03 0,07897443 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 8,405E-03 0,07867185 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 8,405E-03 0,07837157 GO:0045936|negative regulation of phosphate metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 1,000 8,405E-03 0,07807358 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 8,405E-03 0,07777785 ! positive regulation of nuclear division GO:0051785 41 26 1,000 8,405E-03 0,07748435 GO:0045840|positive regulation of mitosis, ! alditol metabolic process GO:0019400 44 26 1,000 8,405E-03 0,07719305 ! regulation of multi-organism process GO:0043900 45 26 1,000 8,405E-03 0,07690394 ! negative regulation of actin filament depolymerization GO:0030835 63 27 1,000 9,046E-03 0,08245905 ! negative regulation of actin filament polymerization GO:0030837 61 27 1,000 9,046E-03 0,08215251 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 9,046E-03 0,08184824 ! response to starvation GO:0042594 47 27 1,000 9,046E-03 0,08154622 ! cellular response to oxidative stress GO:0034599 43 27 1,000 9,046E-03 0,08124642 ! regulation of chromosome organization GO:0033044 49 27 1,000 9,046E-03 0,08094881 ! cellular response to nutrient levels GO:0031669 45 27 1,000 9,046E-03 0,08065338 ! meiosis GO:0007126 143 81 2,000 9,317E-03 0,08277258 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 2,000 9,317E-03 0,08247268 ! meiotic cell cycle GO:0051321 144 82 2,000 9,634E-03 0,08496726 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 9,708E-03 0,08531063 ! negative regulation of protein modification process GO:0031400 66 28 1,000 9,708E-03 0,08500486 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 9,708E-03 0,08470127 ! regulation of response to biotic stimulus GO:0002831 52 28 1,000 9,708E-03 0,08439984 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 9,708E-03 0,08410055 ! negative regulation of protein polymerization GO:0032272 63 28 1,000 9,708E-03 0,08380338 ! intracellular protein transmembrane transport GO:0065002 165 83 2,000 9,957E-03 0,08564993 ! catechol metabolic process GO:0009712 55 29 1,000 0,01039081 0,08906932 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01039081 0,08875789 ! negative regulation of growth GO:0045926 168 85 2,000 0,01062122 0,09040987 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 0,01062122 0,09009595 ! regulation of actin filament depolymerization GO:0030834 67 30 1,000 0,01109441 0,09378424 ! phenol metabolic process GO:0018958 56 30 1,000 0,01109441 0,09346085 ! negative regulation of protein complex assembly GO:0031333 68 30 1,000 0,01109441 0,09313968 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 0,01109441 0,09282071 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01109441 0,09250391 ! regulation of protein transport GO:0051223 165 87 2,000 0,0113107 0,09398652 GO:0070201|regulation of establishment of protein localization, ! cell junction assembly GO:0034329 85 31 1,000 0,01181844 0,09787269 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 0,01181844 0,09754204 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01181844 0,09721361 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,01256266 0,10298851 ! hexose biosynthetic process GO:0019319 53 32 1,000 0,01256266 0,10264407 ! hindbrain development GO:0030902 65 32 1,000 0,01256266 0,10230192 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,01256266 0,10196205 ! regulation of cell adhesion GO:0030155 241 92 2,000 0,01314527 0,10633741 ! negative regulation of MAP kinase activity GO:0043407 78 34 1,000 0,01411076 0,11377089 ! serine family amino acid metabolic process GO:0009069 56 34 1,000 0,01411076 0,11339664 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01411076 0,11302485 ! positive regulation of endocytosis GO:0045807 56 35 1,000 0,01491417 0,11906968 ! biogenic amine biosynthetic process GO:0042401 65 35 1,000 0,01491417 0,11868183 ! regulation of protein localization GO:0032880 188 97 2,000 0,01513982 0,12008628 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,01573686 0,12441798 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 0,01573686 0,12401663 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01573686 0,12361786 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01573686 0,12322165 ! embryonic organ development GO:0048568 67 36 1,000 0,01573686 0,12282797 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 1,000 0,01573686 0,1224368 ! monosaccharide biosynthetic process GO:0046364 57 36 1,000 0,01573686 0,12204811 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,016414 0,12689686 GO:0060538|skeletal muscle organ development, ! mRNA transport GO:0051028 185 100 2,000 0,016414 0,12649656 ! odontogenesis GO:0042476 74 37 1,000 0,0165786 0,12736328 ! cell junction organization GO:0034330 96 37 1,000 0,0165786 0,12696403 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,0165786 0,12656726 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 0,0165786 0,12617297 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,0165786 0,12578113 ! meiosis I GO:0007127 74 38 1,000 0,01743917 0,13190057 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,01743917 0,13149347 ! organic anion transport GO:0015711 82 38 1,000 0,01743917 0,13108887 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 0,01743917 0,13068676 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,01743917 0,13028711 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 0,01743917 0,12988989 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,01831833 0,13602338 ! mammary gland development GO:0030879 93 40 1,000 0,01921589 0,14225579 ! Rho protein signal transduction GO:0007266 88 40 1,000 0,01921589 0,14182602 ! RNA export from nucleus GO:0006405 61 41 1,000 0,0201316 0,14813708 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 1,000 0,0201316 0,14769222 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,0201316 0,14725003 ! gliogenesis GO:0042063 91 41 1,000 0,0201316 0,14681048 ! feeding behavior GO:0007631 69 41 1,000 0,0201316 0,14637354 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,0201316 0,1459392 ! mesenchymal cell development GO:0014031 94 41 1,000 0,0201316 0,14550742 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 95 41 1,000 0,0201316 0,1450782 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,02106527 0,15136017 ! alcohol biosynthetic process GO:0046165 65 42 1,000 0,02106527 0,1509163 ! ribonucleoside metabolic process GO:0009119 64 42 1,000 0,02106527 0,15047502 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,02106527 0,15003632 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,02106527 0,14960017 ! cytokinesis GO:0000910 84 42 1,000 0,02106527 0,14916654 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,02298559 0,16229424 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 1,000 0,02298559 0,16182654 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,02298559 0,16136152 ! phagocytosis GO:0006909 105 44 1,000 0,02298559 0,16089916 ! induction of apoptosis by intracellular signals GO:0008629 95 45 1,000 0,02397183 0,16732336 ! keratinocyte differentiation GO:0030216 81 45 1,000 0,02397183 0,16684665 ! biopolymer methylation GO:0043414 91 45 1,000 0,02397183 0,16637266 ! polyol metabolic process GO:0019751 77 45 1,000 0,02397183 0,16590135 ! maintenance of location in cell GO:0051651 101 45 1,000 0,02397183 0,1654327 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 0,02497516 0,17187133 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 1,000 0,02497516 0,17138854 ! cell growth GO:0016049 90 46 1,000 0,02497516 0,17090846 ! neural tube development GO:0021915 91 47 1,000 0,02599539 0,17739312 ! response to insulin stimulus GO:0032868 98 47 1,000 0,02599539 0,17689899 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02630699 0,17852214 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02630699 0,17802762 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02630699 0,17753583 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02630699 0,17704675 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02630699 0,17656036 ! neuron fate determination GO:0048664 7 5 0,000 0,02630699 0,17607663 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02630699 0,17559555 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02630699 0,17511708 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02630699 0,17464122 ! polyol transport GO:0015791 12 5 0,000 0,02630699 0,17416794 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02630699 0,17369722 ! response to superoxide GO:0000303 10 5 0,000 0,02630699 0,17322903 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02630699 0,17276336 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02630699 0,17230019 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02630699 0,17183949 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02630699 0,17138125 ! female meiosis GO:0007143 10 5 0,000 0,02630699 0,17092545 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02630699 0,17047207 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02630699 0,17002108 ! hypothalamus development GO:0021854 9 5 0,000 0,02630699 0,16957248 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02630699 0,16912624 ! cobalt ion transport GO:0006824 11 5 0,000 0,02630699 0,16868234 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02630699 0,16824076 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02630699 0,16780149 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02630699 0,1673645 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02630699 0,16692979 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02630699 0,16649733 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02630699 0,16606711 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02630699 0,1656391 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02630699 0,16521329 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02630699 0,16478967 ! transposition GO:0032196 9 5 0,000 0,02630699 0,16436821 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,02630699 0,1639489 ! negative chemotaxis GO:0050919 16 5 0,000 0,02630699 0,16353173 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02630699 0,16311667 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02630699 0,16270372 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02630699 0,16229285 ! behavioral response to pain GO:0048266 10 5 0,000 0,02630699 0,16188406 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02630699 0,16147731 ! Notch receptor processing GO:0007220 11 5 0,000 0,02630699 0,16107261 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02630699 0,16066992 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02630699 0,16026925 ! micturition GO:0060073 9 5 0,000 0,02630699 0,15987057 ! copulation GO:0007620 9 5 0,000 0,02630699 0,15947387 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02630699 0,15907913 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02630699 0,15868635 ! bioluminescence GO:0008218 9 5 0,000 0,02630699 0,15829549 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02630699 0,15790656 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02630699 0,15751953 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02630699 0,1571344 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02630699 0,15675115 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02630699 0,15636976 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02630699 0,15599022 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02630699 0,15561252 ! grooming behavior GO:0007625 6 5 0,000 0,02630699 0,15523664 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02630699 0,15486258 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02630699 0,15449031 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02630699 0,15411983 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02630699 0,15375112 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,02630699 0,15338418 ! lymph vessel development GO:0001945 10 5 0,000 0,02630699 0,15301898 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02630699 0,15265551 ! endochondral ossification GO:0001958 17 5 0,000 0,02630699 0,15229377 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! single strand break repair GO:0000012 8 5 0,000 0,02630699 0,15193373 ! parathyroid gland development GO:0060017 14 5 0,000 0,02630699 0,1515754 ! anagen GO:0042640 7 5 0,000 0,02630699 0,15121875 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02630699 0,15086378 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02630699 0,15051047 ! cytokine secretion GO:0050663 15 5 0,000 0,02630699 0,15015881 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02630699 0,14980879 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02630699 0,1494604 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02630699 0,14911362 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02630699 0,14876845 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02630699 0,14842487 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02630699 0,14808288 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02630699 0,14774246 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02630699 0,1474036 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02630699 0,14706629 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02630699 0,14673052 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02630699 0,14639629 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02630699 0,14606357 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02630699 0,14573236 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02630699 0,14540265 ! microvillus organization GO:0032528 8 5 0,000 0,02630699 0,14507442 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02630699 0,14474768 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02630699 0,1444224 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02630699 0,14409859 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02630699 0,14377622 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02630699 0,14345529 ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02630699 0,14313579 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02630699 0,14281771 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02630699 0,14250104 ! muscle cell migration GO:0014812 8 5 0,000 0,02630699 0,14218577 ! mitochondrial fission GO:0000266 8 5 0,000 0,02630699 0,1418719 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02630699 0,1415594 ! mRNA transcription GO:0009299 10 5 0,000 0,02630699 0,14124829 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02630699 0,14093853 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02630699 0,14063013 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02630699 0,14032308 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02630699 0,14001736 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02630699 0,13971298 ! monocyte activation GO:0042117 10 5 0,000 0,02630699 0,13940991 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02630699 0,13910816 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02630699 0,13880771 ! response to food GO:0032094 6 5 0,000 0,02630699 0,13850856 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02630699 0,13821069 ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02630699 0,1379141 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02630699 0,13761878 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,02630699 0,13732472 ! forebrain neuron development GO:0021884 13 5 0,000 0,02630699 0,13703192 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02630699 0,13674036 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02630699 0,13645004 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02630699 0,13616095 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02630699 0,13587309 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02630699 0,13558643 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02630699 0,13530099 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02630699 0,13501674 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02630699 0,13473369 ! lipid glycosylation GO:0030259 7 5 0,000 0,02630699 0,13445182 ! nucleobase transport GO:0015851 6 5 0,000 0,02630699 0,13417113 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02630699 0,1338916 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02630699 0,13361324 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02630699 0,13333604 ! basic amino acid transport GO:0015802 12 5 0,000 0,02630699 0,13305998 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02630699 0,13278506 ! actin nucleation GO:0045010 11 5 0,000 0,02630699 0,13251128 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02630699 0,13223862 ! depurination GO:0045007 5 5 0,000 0,02630699 0,13196708 ! depyrimidination GO:0045008 10 5 0,000 0,02630699 0,13169666 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02630699 0,13142734 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02630699 0,13115912 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02630699 0,130892 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02630699 0,13062595 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02630699 0,13036099 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02630699 0,1300971 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02630699 0,12983428 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02630699 0,12957252 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02630699 0,12931181 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02630699 0,12905215 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02630699 0,12879353 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02630699 0,12853594 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02630699 0,12827938 ! response to arsenic GO:0046685 11 5 0,000 0,02630699 0,12802384 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02630699 0,12776932 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02630699 0,12751581 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02630699 0,12726331 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02630699 0,1270118 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02630699 0,12676128 ! response to mercury ion GO:0046689 8 5 0,000 0,02630699 0,12651175 ! response to cadmium ion GO:0046686 7 5 0,000 0,02630699 0,1262632 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02630699 0,12601563 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02630699 0,12576902 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02630699 0,12552338 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02630699 0,12527869 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02630699 0,12503496 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02630699 0,12479217 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02630699 0,12455033 ! decidualization GO:0046697 11 5 0,000 0,02630699 0,12430942 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02630699 0,12406944 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02630699 0,12383039 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02630699 0,12359225 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02630699 0,12335503 ! embryonic cleavage GO:0040016 6 5 0,000 0,02630699 0,12311872 ! peroxisome fission GO:0016559 5 5 0,000 0,02630699 0,12288331 ! histone demethylation GO:0016577 13 5 0,000 0,02630699 0,1226488 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02630699 0,12241518 ! mitotic recombination GO:0006312 9 5 0,000 0,02630699 0,12218245 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02630699 0,12195061 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02630699 0,12171964 ! metaphase plate congression GO:0051310 7 5 0,000 0,02630699 0,12148955 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02630699 0,12126032 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02630699 0,12103196 ! enteric nervous system development GO:0048484 8 5 0,000 0,02630699 0,12080445 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02630699 0,1205778 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02630699 0,120352 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02630699 0,12012705 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02630699 0,11990293 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02630699 0,11967965 ! B cell homeostasis GO:0001782 13 5 0,000 0,02630699 0,11945719 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02630699 0,11923557 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02630699 0,11901476 ! metaphase GO:0051323 11 5 0,000 0,02630699 0,11879477 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02630699 0,11857559 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02630699 0,11835722 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02630699 0,11813965 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02630699 0,11792288 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02630699 0,1177069 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02630699 0,11749172 ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02630699 0,11727732 ! response to redox state GO:0051775 6 5 0,000 0,02630699 0,1170637 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02630699 0,11685085 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02630699 0,11663878 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02630699 0,11642748 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02630699 0,11621694 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02630699 0,11600717 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02630699 0,11579814 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02630699 0,11558987 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02630699 0,11538235 ! striatum development GO:0021756 14 5 0,000 0,02630699 0,11517557 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02630699 0,11496953 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02630699 0,11476423 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02630699 0,11455966 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02630699 0,11435582 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02630699 0,1141527 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02630699 0,1139503 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02630699 0,11374862 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02630699 0,11354765 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02630699 0,11334739 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02630699 0,11314783 ! neuroprotection GO:0043526 8 5 0,000 0,02630699 0,11294898 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02630699 0,11275082 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02630699 0,11255336 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02630699 0,11235659 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02630699 0,11216051 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02630699 0,1119651 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02630699 0,11177038 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02630699 0,11157634 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02630699 0,11138296 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02630699 0,11119026 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,02630699 0,11099822 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02630699 0,11080684 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02630699 0,11061613 ! spindle assembly GO:0051225 6 5 0,000 0,02630699 0,11042607 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02630699 0,11023665 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02630699 0,11004789 ! protein palmitoylation GO:0018345 12 5 0,000 0,02630699 0,10985978 ! drug metabolic process GO:0017144 7 5 0,000 0,02630699 0,1096723 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02630699 0,10948547 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02630699 0,10929927 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02630699 0,1091137 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,02703231 0,11193207 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,02703231 0,11174268 ! endosome transport GO:0016197 127 48 1,000 0,02703231 0,11155392 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,02703231 0,1113658 ! methylation GO:0032259 97 48 1,000 0,02703231 0,11117832 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,0280857 0,11531659 ! protein homooligomerization GO:0051260 84 49 1,000 0,0280857 0,11512311 ! induction of apoptosis by extracellular signals GO:0008624 99 50 1,000 0,02915538 0,11930754 ! regulation of ossification GO:0030278 123 50 1,000 0,02915538 0,11910802 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,02915538 0,11890918 ! epidermal cell differentiation GO:0009913 87 50 1,000 0,02915538 0,118711 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,03024114 0,12292697 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,03134278 0,12719337 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03148519 0,12755938 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03148519 0,12734819 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03148519 0,1271377 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03148519 0,1269279 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03148519 0,12671879 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03148519 0,12651037 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03148519 0,12630264 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03148519 0,12609559 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03148519 0,12588921 ! response to oxygen radical GO:0000305 11 6 0,000 0,03148519 0,12568351 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03148519 0,12547848 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03148519 0,12527412 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03148519 0,12507042 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03148519 0,12486738 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03148519 0,124665 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03148519 0,12446328 ! forebrain regionalization GO:0021871 9 6 0,000 0,03148519 0,12426221 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03148519 0,12406179 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03148519 0,12386201 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03148519 0,12366287 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03148519 0,12346438 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03148519 0,12326652 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03148519 0,12306929 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03148519 0,1228727 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03148519 0,12267673 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03148519 0,12248138 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03148519 0,12228666 ! malate metabolic process GO:0006108 13 6 0,000 0,03148519 0,12209255 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03148519 0,12189906 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03148519 0,12170618 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03148519 0,12151391 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03148519 0,12132225 ! protein refolding GO:0042026 15 6 0,000 0,03148519 0,12113119 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03148519 0,12094074 ! opsonization GO:0008228 8 6 0,000 0,03148519 0,12075088 ! mating behavior GO:0007617 7 6 0,000 0,03148519 0,12056161 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03148519 0,12037294 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03148519 0,12018486 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03148519 0,11999736 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03148519 0,11981045 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03148519 0,11962412 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03148519 0,11943837 ! toxin metabolic process GO:0009404 11 6 0,000 0,03148519 0,11925319 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03148519 0,11906859 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03148519 0,11888456 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03148519 0,11870109 ! nuclear migration GO:0007097 13 6 0,000 0,03148519 0,11851819 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03148519 0,11833586 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03148519 0,11815408 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03148519 0,11797286 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03148519 0,1177922 ! thymic T cell selection GO:0045061 16 6 0,000 0,03148519 0,11761209 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03148519 0,11743253 ! protein lipoylation GO:0009249 10 6 0,000 0,03148519 0,11725352 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03148519 0,11707505 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03148519 0,11689712 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03148519 0,11671974 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03148519 0,11654289 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03148519 0,11636658 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03148519 0,1161908 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03148519 0,11601555 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03148519 0,11584082 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03148519 0,11566663 ! hyperosmotic response GO:0006972 10 6 0,000 0,03148519 0,11549295 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03148519 0,1153198 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03148519 0,11514717 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03148519 0,11497505 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03148519 0,11480344 ! urea metabolic process GO:0019627 7 6 0,000 0,03148519 0,11463235 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03148519 0,11446177 ! neutrophil activation GO:0042119 7 6 0,000 0,03148519 0,11429169 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03148519 0,11412212 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03148519 0,11395305 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03148519 0,11378448 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03148519 0,11361641 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03148519 0,11344883 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03148519 0,11328175 ! neuron apoptosis GO:0051402 15 6 0,000 0,03148519 0,11311516 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03148519 0,11294906 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03148519 0,11278344 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03148519 0,11261831 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03148519 0,11245367 ! carnitine transport GO:0015879 10 6 0,000 0,03148519 0,1122895 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03148519 0,11212581 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03148519 0,1119626 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03148519 0,11179987 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03148519 0,1116376 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03148519 0,11147581 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03148519 0,11131448 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03148519 0,11115362 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03148519 0,11099323 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03148519 0,1108333 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03148519 0,11067382 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,03148519 0,11051481 ! response to UV-C GO:0010225 14 6 0,000 0,03148519 0,11035625 ! astrocyte development GO:0014002 16 6 0,000 0,03148519 0,11019815 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03148519 0,1100405 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03148519 0,1098833 ! interaction with symbiont GO:0051702 14 6 0,000 0,03148519 0,10972654 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03148519 0,10957024 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03148519 0,10941438 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03148519 0,10925896 ! response to copper ion GO:0046688 10 6 0,000 0,03148519 0,10910398 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03148519 0,10894944 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03148519 0,10879534 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03148519 0,10864168 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03148519 0,10848845 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03148519 0,10833564 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03148519 0,10818327 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03148519 0,10803133 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03148519 0,10787981 ! hair follicle maturation GO:0048820 8 6 0,000 0,03148519 0,10772872 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03148519 0,10757805 ! Schwann cell development GO:0014044 15 6 0,000 0,03148519 0,1074278 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03148519 0,10727797 ! response to pheromone GO:0019236 6 6 0,000 0,03148519 0,10712856 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03148519 0,10697957 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03148519 0,10683098 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,03148519 0,10668281 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03148519 0,10653505 ! subpallium development GO:0021544 15 6 0,000 0,03148519 0,1063877 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03148519 0,10624076 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03148519 0,10609422 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03148519 0,10594808 ! G2 phase GO:0051319 16 6 0,000 0,03148519 0,10580235 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03148519 0,10565702 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03148519 0,10551208 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03148519 0,10536754 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03148519 0,1052234 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03148519 0,10507966 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03148519 0,1049363 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03148519 0,10479333 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03148519 0,10465076 ! receptor internalization GO:0031623 11 6 0,000 0,03148519 0,10450857 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03148519 0,10436677 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03148519 0,10422535 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03148519 0,10408431 ! protein deubiquitination GO:0016579 16 6 0,000 0,03148519 0,10394366 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03148519 0,10380338 ! protein destabilization GO:0031648 9 6 0,000 0,03148519 0,10366349 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03148519 0,10352397 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03148519 0,10338482 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03148519 0,10324605 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03148519 0,10310765 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03148519 0,10296962 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03148519 0,10283196 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03148519 0,10269467 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03148519 0,10255774 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03148519 0,10242118 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03148519 0,10228498 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03148519 0,10214915 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03148519 0,10201367 ! neural plate development GO:0001840 9 6 0,000 0,03148519 0,10187855 ! catecholamine transport GO:0051937 9 6 0,000 0,03148519 0,10174379 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03148519 0,10160939 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03148519 0,10147534 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03148519 0,10134164 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03148519 0,1012083 ! maternal placenta development GO:0001893 12 6 0,000 0,03148519 0,10107531 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03148519 0,10094266 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03148519 0,10081036 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,03148519 0,10067841 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03148519 0,10054681 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03148519 0,10041555 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03148519 0,10028463 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03148519 0,10015405 GO:0055081|anion homeostasis, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,0324601 0,10312097 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 1,000 0,0324601 0,10298705 ! vesicle organization GO:0016050 127 53 1,000 0,0324601 0,10285347 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,0324601 0,10272024 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,03359291 0,1061675 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 1,000 0,03359291 0,10603033 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,03474101 0,10951262 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 1,000 0,03474101 0,1093715 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,03474101 0,10923074 ! cell recognition GO:0008037 98 55 1,000 0,03474101 0,10909034 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,03474101 0,1089503 ! cell maturation GO:0048469 107 55 1,000 0,03474101 0,10881062 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,03474101 0,1086713 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,03590421 0,11216622 ! tRNA transcription GO:0009304 17 7 0,000 0,03663599 0,11430616 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03663599 0,11416036 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03663599 0,11401493 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03663599 0,11386988 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03663599 0,11372519 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03663599 0,11358087 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03663599 0,11343691 ! sleep GO:0030431 16 7 0,000 0,03663599 0,11329332 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03663599 0,11315009 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03663599 0,11300723 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03663599 0,11286472 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03663599 0,11272257 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03663599 0,11258078 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03663599 0,11243935 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03663599 0,11229827 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03663599 0,11215755 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03663599 0,11201718 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03663599 0,11187715 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03663599 0,11173748 ! glycolipid transport GO:0046836 11 7 0,000 0,03663599 0,11159816 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03663599 0,11145918 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,03663599 0,11132055 ! neuron adhesion GO:0007158 14 7 0,000 0,03663599 0,11118227 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,03663599 0,11104432 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03663599 0,11090672 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03663599 0,11076946 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03663599 0,11063254 ! mRNA stabilization GO:0048255 18 7 0,000 0,03663599 0,11049596 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,03663599 0,11035971 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03663599 0,1102238 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03663599 0,11008822 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03663599 0,10995298 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03663599 0,10981807 ! lipoprotein transport GO:0042953 14 7 0,000 0,03663599 0,10968348 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03663599 0,10954923 ! rhythmic behavior GO:0007622 17 7 0,000 0,03663599 0,10941531 ! neuron remodeling GO:0016322 16 7 0,000 0,03663599 0,10928171 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03663599 0,10914844 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03663599 0,1090155 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03663599 0,10888288 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03663599 0,10875058 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03663599 0,1086186 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03663599 0,10848694 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03663599 0,1083556 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03663599 0,10822458 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03663599 0,10809387 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03663599 0,10796348 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03663599 0,1078334 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03663599 0,10770364 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03663599 0,10757419 ! spinal cord patterning GO:0021511 14 7 0,000 0,03663599 0,10744505 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03663599 0,10731622 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03663599 0,10718769 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03663599 0,10705948 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03663599 0,10693157 ! adrenal gland development GO:0030325 17 7 0,000 0,03663599 0,10680397 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03663599 0,10667667 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03663599 0,10654967 ! ovulation GO:0030728 10 7 0,000 0,03663599 0,10642298 ! adenohypophysis development GO:0021984 11 7 0,000 0,03663599 0,10629658 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03663599 0,10617049 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03663599 0,1060447 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03663599 0,1059192 ! microtubule nucleation GO:0007020 21 7 0,000 0,03663599 0,105794 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03663599 0,1056691 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03663599 0,10554449 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03663599 0,10542017 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03663599 0,10529615 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03663599 0,10517241 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03663599 0,10504897 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03663599 0,10492582 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03663599 0,10480296 ! galactose metabolic process GO:0006012 13 7 0,000 0,03663599 0,10468038 ! vesicle fusion GO:0006906 20 7 0,000 0,03663599 0,10455809 ! response to dietary excess GO:0002021 8 7 0,000 0,03663599 0,10443608 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03663599 0,10431436 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03663599 0,10419293 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03663599 0,10407177 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 0,000 0,03663599 0,1039509 ! nucleoside transport GO:0015858 11 7 0,000 0,03663599 0,10383031 ! nucleoside salvage GO:0043174 11 7 0,000 0,03663599 0,10370999 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03663599 0,10358996 ! male sex determination GO:0030238 15 7 0,000 0,03663599 0,1034702 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03663599 0,10335072 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03663599 0,10323152 ! parturition GO:0007567 16 7 0,000 0,03663599 0,10311258 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03663599 0,10299393 ! rRNA modification GO:0000154 14 7 0,000 0,03663599 0,10287554 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03663599 0,10275743 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03663599 0,10263959 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03663599 0,10252202 ! monocyte differentiation GO:0030224 16 7 0,000 0,03663599 0,10240472 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03663599 0,10228768 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03663599 0,10217092 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03663599 0,10205442 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03663599 0,10193818 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03663599 0,10182221 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03663599 0,1017065 ! fibrinolysis GO:0042730 11 7 0,000 0,03663599 0,10159106 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,03663599 0,10147588 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03663599 0,10136096 ! eating behavior GO:0042755 8 7 0,000 0,03663599 0,10124629 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03663599 0,10113189 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03663599 0,10101775 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03663599 0,10090386 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03663599 0,10079023 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03663599 0,10067685 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03663599 0,10056373 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03663599 0,10045087 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03663599 0,10033826 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03663599 0,10022589 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03663599 0,10011378 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03663599 0,10000193 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03663599 0,09989032 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03663599 0,09977896 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03663599 0,09966784 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03663599 0,09955698 ! histone ubiquitination GO:0016574 9 7 0,000 0,03663599 0,09944636 ! regulation of meiosis GO:0040020 12 7 0,000 0,03663599 0,09933599 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03663599 0,09922586 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03663599 0,09911597 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03663599 0,09900633 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03663599 0,09889693 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03663599 0,09878777 ! transcription termination GO:0006353 14 7 0,000 0,03663599 0,09867886 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03663599 0,09857018 ! anaphase GO:0051322 18 7 0,000 0,03663599 0,09846174 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03663599 0,09835354 ! axonal fasciculation GO:0007413 19 7 0,000 0,03663599 0,09824558 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03663599 0,09813785 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03663599 0,09803037 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03663599 0,09792311 ! diuresis GO:0030146 12 7 0,000 0,03663599 0,09781609 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03663599 0,09770931 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03663599 0,09760275 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03663599 0,09749643 ! antibiotic transport GO:0042891 9 7 0,000 0,03663599 0,09739034 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03663599 0,09728448 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03663599 0,09717885 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03663599 0,09707345 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03663599 0,09696828 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03663599 0,09686334 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03663599 0,09675862 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03663599 0,09665413 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03663599 0,09654986 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03663599 0,09644582 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03663599 0,09634201 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03663599 0,09623841 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03663599 0,09613504 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03663599 0,09603189 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03663599 0,09592896 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03663599 0,09582626 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03663599 0,09572377 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03663599 0,0956215 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03663599 0,09551945 ! muscle adaptation GO:0043500 13 7 0,000 0,03663599 0,09541762 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03663599 0,095316 ! retina homeostasis GO:0001895 12 7 0,000 0,03663599 0,0952146 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03663599 0,09511342 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03663599 0,09501245 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03663599 0,09491169 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03663599 0,09481115 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,03708232 0,09586465 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,03708232 0,09576332 ! regulation of actin filament length GO:0030832 118 58 1,000 0,03827514 0,09873936 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,03827514 0,0986352 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 1,000 0,03827514 0,09853127 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,03827514 0,09842755 ! maintenance of location GO:0051235 124 58 1,000 0,03827514 0,09832405 ! establishment of organelle localization GO:0051656 122 59 1,000 0,0394825 0,10131906 ! regulation of endocytosis GO:0030100 104 60 1,000 0,0407042 0,10434456 ! adult behavior GO:0030534 104 60 1,000 0,0407042 0,10423518 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04175955 0,10682573 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04175955 0,10671399 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,04175955 0,10660248 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,04175955 0,1064912 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04175955 0,10638016 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04175955 0,10626934 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04175955 0,10615876 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04175955 0,10604841 ! male meiosis GO:0007140 9 8 0,000 0,04175955 0,10593829 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04175955 0,10582839 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 14 8 0,000 0,04175955 0,10571873 ! response to zinc ion GO:0010043 12 8 0,000 0,04175955 0,10560929 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04175955 0,10550007 ! oligopeptide transport GO:0006857 16 8 0,000 0,04175955 0,10539108 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04175955 0,10528232 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04175955 0,10517378 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04175955 0,10506547 ! signal peptide processing GO:0006465 12 8 0,000 0,04175955 0,10495738 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04175955 0,10484951 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04175955 0,10474186 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04175955 0,10463443 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04175955 0,10452722 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04175955 0,10442024 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,04175955 0,10431347 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04175955 0,10420692 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04175955 0,10410058 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04175955 0,10399447 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04175955 0,10388856 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04175955 0,10378288 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04175955 0,10367741 ! reflex GO:0060004 17 8 0,000 0,04175955 0,10357215 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04175955 0,10346711 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04175955 0,10336228 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04175955 0,10325766 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04175955 0,10315326 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04175955 0,10304906 ! histidine catabolic process GO:0006548 10 8 0,000 0,04175955 0,10294508 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04175955 0,1028413 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04175955 0,10273773 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04175955 0,10263438 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,04175955 0,10253123 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04175955 0,10242828 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,04175955 0,10232555 ! melanin metabolic process GO:0006582 17 8 0,000 0,04175955 0,10222302 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04175955 0,10212069 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04175955 0,10201857 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04175955 0,10191665 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04175955 0,10181494 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04175955 0,10171343 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,04175955 0,10161212 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04175955 0,10151102 ! purine salvage GO:0043101 12 8 0,000 0,04175955 0,10141011 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04175955 0,1013094 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04175955 0,1012089 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04175955 0,10110859 ! osteoblast development GO:0002076 17 8 0,000 0,04175955 0,10100849 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04175955 0,10090858 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04175955 0,10080886 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04175955 0,10070935 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04175955 0,10061003 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04175955 0,10051091 ! response to UV-B GO:0010224 17 8 0,000 0,04175955 0,10041198 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04175955 0,10031325 ! intermediate filament organization GO:0045109 12 8 0,000 0,04175955 0,10021471 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04175955 0,10011636 ! cellular extravasation GO:0045123 13 8 0,000 0,04175955 0,10001821 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04175955 0,09992025 ! response to antibiotic GO:0046677 11 8 0,000 0,04175955 0,09982248 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04175955 0,0997249 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04175955 0,09962751 ! DNA topological change GO:0006265 12 8 0,000 0,04175955 0,09953031 ! response to tropane GO:0014073 15 8 0,000 0,04175955 0,0994333 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,04175955 0,09933649 ! melanosome transport GO:0032402 13 8 0,000 0,04175955 0,09923985 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04175955 0,09914341 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04175955 0,09904716 ! mast cell activation GO:0045576 14 8 0,000 0,04175955 0,09895109 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04175955 0,0988552 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04175955 0,09875951 ! gas homeostasis GO:0033483 14 8 0,000 0,04175955 0,09866399 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04175955 0,09856867 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04175955 0,09847352 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04175955 0,09837856 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04175955 0,09828379 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04175955 0,09818919 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04175955 0,09809478 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04175955 0,09800055 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04175955 0,0979065 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04175955 0,09781263 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04175955 0,09771894 ! response to tumor cell GO:0002347 16 8 0,000 0,04175955 0,09762543 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04175955 0,09753209 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04175955 0,09743894 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04175955 0,09734596 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04175955 0,09725317 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04175955 0,09716054 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04175955 0,0970681 ! hormone catabolic process GO:0042447 17 8 0,000 0,04175955 0,09697583 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04175955 0,09688373 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04175955 0,09679181 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04175955 0,09670007 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04175955 0,09660849 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04175955 0,0965171 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04175955 0,09642587 ! adult feeding behavior GO:0008343 10 8 0,000 0,04175955 0,09633482 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04175955 0,09624393 ! ATP catabolic process GO:0006200 11 8 0,000 0,04175955 0,09615322 ! blastocyst growth GO:0001832 19 8 0,000 0,04175955 0,09606268 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04175955 0,09597231 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04175955 0,09588211 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04175955 0,09579208 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04175955 0,09570222 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04175955 0,09561253 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04175955 0,09552301 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04175955 0,09543365 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04175955 0,09534446 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04175955 0,09525543 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04175955 0,09516658 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04175955 0,09507788 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04175955 0,09498936 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04175955 0,094901 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04175955 0,0948128 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04175955 0,09472476 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04175955 0,09463689 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04175955 0,09454918 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04175955 0,09446164 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04175955 0,09437426 ! regulation of cellular component size GO:0032535 125 61 1,000 0,04194006 0,09469461 ! regulation of Rab protein signal transduction GO:0032483 109 61 1,000 0,04194006 0,09460718 GO:0032313|regulation of Rab GTPase activity, ! regulation of heart contraction GO:0008016 123 61 1,000 0,04194006 0,0945199 ! negative regulation of response to stimulus GO:0048585 106 61 1,000 0,04194006 0,09443279 ! viral reproductive process GO:0022415 132 62 1,000 0,0431899 0,09715739 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,0431899 0,09706801 ! nucleoside metabolic process GO:0009116 91 62 1,000 0,0431899 0,09697879 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,04445353 0,09972449 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,04445353 0,099633 ! response to peptide hormone stimulus GO:0043434 129 64 1,000 0,04573078 0,10240173 ! axon extension GO:0048675 16 9 0,000 0,046856 0,10482527 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,046856 0,10472937 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,046856 0,10463364 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,046856 0,10453808 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,046856 0,1044427 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,046856 0,10434749 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,046856 0,10425246 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,046856 0,1041576 ! reproductive behavior GO:0019098 22 9 0,000 0,046856 0,10406291 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,046856 0,10396839 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,046856 0,10387404 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,046856 0,10377987 ! UTP metabolic process GO:0046051 10 9 0,000 0,046856 0,10368587 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,046856 0,10359203 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,046856 0,10349837 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,046856 0,10340488 ! regulation of histone modification GO:0031056 14 9 0,000 0,046856 0,10331155 ! regulation of glycolysis GO:0006110 20 9 0,000 0,046856 0,10321839 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,046856 0,1031254 ! equilibrioception GO:0050957 20 9 0,000 0,046856 0,10303258 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,046856 0,10293993 ! chemosensory behavior GO:0007635 21 9 0,000 0,046856 0,10284744 ! microtubule bundle formation GO:0001578 22 9 0,000 0,046856 0,10275511 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,046856 0,10266296 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,046856 0,10257097 ! leukocyte degranulation GO:0043299 16 9 0,000 0,046856 0,10247914 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,046856 0,10238748 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,046856 0,10229598 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,046856 0,10220464 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,046856 0,10211347 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,046856 0,10202246 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,046856 0,10193161 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,046856 0,10184092 ! protein targeting to ER GO:0045047 25 9 0,000 0,046856 0,1017504 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,046856 0,10166003 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,046856 0,10156983 ! T cell selection GO:0045058 27 9 0,000 0,046856 0,10147978 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,046856 0,1013899 ! endosome organization GO:0007032 20 9 0,000 0,046856 0,10130017 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,046856 0,10121061 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,046856 0,1011212 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,046856 0,10103195 ! mannose metabolic process GO:0006013 13 9 0,000 0,046856 0,10094285 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,046856 0,10085392 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,046856 0,10076514 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,046856 0,10067651 ! receptor clustering GO:0043113 20 9 0,000 0,046856 0,10058805 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,046856 0,10049973 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,046856 0,10041158 ! retinol metabolic process GO:0042572 20 9 0,000 0,046856 0,10032357 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,046856 0,10023572 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,046856 0,10014803 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,046856 0,10006049 ! macrophage differentiation GO:0030225 15 9 0,000 0,046856 0,0999731 ! oligodendrocyte development GO:0014003 11 9 0,000 0,046856 0,09988586 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,046856 0,09979878 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,046856 0,09971184 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,046856 0,09962506 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,046856 0,09953843 ! response to amine stimulus GO:0014075 13 9 0,000 0,046856 0,09945195 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,046856 0,09936562 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,046856 0,09927944 ! erythrocyte development GO:0048821 17 9 0,000 0,046856 0,09919341 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,046856 0,09910753 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,046856 0,0990218 ! renal water homeostasis GO:0003091 15 9 0,000 0,046856 0,09893621 ! postreplication repair GO:0006301 25 9 0,000 0,046856 0,09885077 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,046856 0,09876549 ! icosanoid secretion GO:0032309 15 9 0,000 0,046856 0,09868034 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,046856 0,09859535 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,046856 0,0985105 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,046856 0,09842579 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,046856 0,09834123 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,046856 0,09825682 ! sterol catabolic process GO:0016127 14 9 0,000 0,046856 0,09817255 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,046856 0,09808843 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,046856 0,09800445 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,046856 0,09792061 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,046856 0,09783692 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,046856 0,09775337 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,046856 0,09766996 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,046856 0,0975867 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,046856 0,09750358 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,046856 0,09742059 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,046856 0,09733775 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,046856 0,09725505 ! purine base metabolic process GO:0006144 25 9 0,000 0,046856 0,09717249 ! pigment granule transport GO:0051904 17 9 0,000 0,046856 0,09709007 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,046856 0,09700779 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,046856 0,09692565 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,046856 0,09684365 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,046856 0,09676179 ! mitochondrion localization GO:0051646 18 9 0,000 0,046856 0,09668007 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,04702146 0,09693959 ! nucleoside monophosphate metabolic process GO:0009123 117 65 1,000 0,04702146 0,09685785 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,04832539 0,09945993 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,04832539 0,09937621 ! activation of MAPK activity GO:0000187 124 67 1,000 0,04964241 0,10199867 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,04964241 0,10191295 GO:0035113|embryonic appendage morphogenesis, ! myeloid cell differentiation GO:0030099 126 67 1,000 0,04964241 0,10182738 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,05097234 0,10446764 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,05097234 0,10438007 ! viral reproduction GO:0016032 142 68 1,000 0,05097234 0,10429265 ! regulation of lipase activity GO:0060191 137 68 1,000 0,05097234 0,10420538 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,05192548 0,10606518 ! regulation of developmental growth GO:0048638 16 10 0,000 0,05192548 0,10597657 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,05192548 0,10588811 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05192548 0,10579979 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05192548 0,10571163 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05192548 0,10562361 ! associative learning GO:0008306 21 10 0,000 0,05192548 0,10553574 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,05192548 0,10544801 ! phosphate transport GO:0006817 24 10 0,000 0,05192548 0,10536043 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05192548 0,10527299 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,05192548 0,1051857 ! CTP metabolic process GO:0046036 11 10 0,000 0,05192548 0,10509855 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,05192548 0,10501155 ! GTP metabolic process GO:0046039 11 10 0,000 0,05192548 0,10492469 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05192548 0,10483798 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05192548 0,10475141 ! social behavior GO:0035176 29 10 0,000 0,05192548 0,10466498 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,05192548 0,10457869 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,05192548 0,10449255 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,05192548 0,10440655 ! androgen metabolic process GO:0008209 17 10 0,000 0,05192548 0,10432069 ! phospholipid efflux GO:0033700 19 10 0,000 0,05192548 0,10423497 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05192548 0,10414939 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05192548 0,10406395 ! lung alveolus development GO:0048286 26 10 0,000 0,05192548 0,10397865 ! pathogenesis GO:0009405 17 10 0,000 0,05192548 0,10389349 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05192548 0,10380847 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,05192548 0,10372359 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05192548 0,10363885 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,05192548 0,10355425 ! endoderm development GO:0007492 18 10 0,000 0,05192548 0,10346978 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,05192548 0,10338546 ! arginine catabolic process GO:0006527 17 10 0,000 0,05192548 0,10330127 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05192548 0,10321721 ! proline metabolic process GO:0006560 13 10 0,000 0,05192548 0,1031333 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05192548 0,10304952 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05192548 0,10296587 ! V(D)J recombination GO:0033151 34 10 0,000 0,05192548 0,10288236 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05192548 0,10279899 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,05192548 0,10271575 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05192548 0,10263265 ! B cell proliferation GO:0042100 19 10 0,000 0,05192548 0,10254968 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05192548 0,10246684 ! multicellular organism growth GO:0035264 19 10 0,000 0,05192548 0,10238414 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05192548 0,10230158 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,05192548 0,10221914 ! ruffle organization GO:0031529 17 10 0,000 0,05192548 0,10213684 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05192548 0,10205467 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05192548 0,10197263 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05192548 0,10189073 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05192548 0,10180895 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,05192548 0,10172731 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05192548 0,1016458 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,05192548 0,10156441 ! motor axon guidance GO:0008045 22 10 0,000 0,05192548 0,10148316 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05192548 0,10140204 ! regulation of bone resorption GO:0045124 25 10 0,000 0,05192548 0,10132105 ! protein heterooligomerization GO:0051291 17 10 0,000 0,05192548 0,10124019 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,05192548 0,10115945 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,05192548 0,10107885 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,05192548 0,10099837 ! segment specification GO:0007379 15 10 0,000 0,05192548 0,10091802 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,05192548 0,1008378 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,05192548 0,10075771 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05192548 0,10067774 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05192548 0,1005979 ! response to dsRNA GO:0043331 23 10 0,000 0,05192548 0,10051819 ! DNA ligation GO:0006266 18 10 0,000 0,05192548 0,1004386 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,05192548 0,10035914 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05192548 0,10027981 ! melanosome localization GO:0032400 16 10 0,000 0,05192548 0,1002006 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05192548 0,10012151 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,05192548 0,10004255 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05192548 0,09996371 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05192548 0,099885 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,05192548 0,09980642 ! induction of an organ GO:0001759 17 10 0,000 0,05192548 0,09972795 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05192548 0,09964961 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05192548 0,09957139 ! protein sumoylation GO:0016925 17 10 0,000 0,05192548 0,0994933 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,05192548 0,09941532 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05192548 0,09933747 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05192548 0,09925974 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05192548 0,09918214 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05192548 0,09910465 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05192548 0,09902729 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,05192548 0,09895004 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05192548 0,09887292 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,05192548 0,09879591 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05192548 0,09871903 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05192548 0,09864227 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05192548 0,09856562 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05192548 0,09848909 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05192548 0,09841269 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,05192548 0,0983364 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,05192548 0,09826023 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,05192548 0,09818417 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05192548 0,09810824 ! blastocyst formation GO:0001825 18 10 0,000 0,05192548 0,09803242 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05192548 0,09795672 ! cerebellar cortex development GO:0021695 16 10 0,000 0,05192548 0,09788114 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,05192548 0,09780567 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,05192548 0,09773032 ! negative regulation of protein kinase activity GO:0006469 144 69 1,000 0,052315 0,09838764 ! lung development GO:0030324 165 69 1,000 0,052315 0,09831196 ! urogenital system development GO:0001655 149 69 1,000 0,052315 0,09823639 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,052315 0,09816094 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,052315 0,09808561 ! cellular amino acid catabolic process GO:0009063 120 69 1,000 0,052315 0,09801039 ! developmental maturation GO:0021700 128 69 1,000 0,052315 0,09793529 ! negative regulation of kinase activity GO:0033673 145 70 1,000 0,05367023 0,10039538 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,05503785 0,10287487 ! appendage morphogenesis GO:0035107 150 72 1,000 0,05641769 0,10537341 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 1,000 0,05641769 0,10529291 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,05641769 0,10521253 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,05696815 0,10615804 ! respiratory burst GO:0045730 17 11 0,000 0,05696815 0,10607712 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05696815 0,10599633 ! neuron fate specification GO:0048665 18 11 0,000 0,05696815 0,10591567 ! telencephalon cell migration GO:0022029 23 11 0,000 0,05696815 0,10583512 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,05696815 0,1057547 ! thyroid gland development GO:0030878 26 11 0,000 0,05696815 0,1056744 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,05696815 0,10559422 ! synapsis GO:0007129 14 11 0,000 0,05696815 0,10551417 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05696815 0,10543423 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05696815 0,10535442 ! response to pain GO:0048265 27 11 0,000 0,05696815 0,10527472 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,05696815 0,10519515 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05696815 0,1051157 ! blood vessel remodeling GO:0001974 30 11 0,000 0,05696815 0,10503637 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,05696815 0,10495715 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,05696815 0,10487806 ! bone resorption GO:0045453 16 11 0,000 0,05696815 0,10479909 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05696815 0,10472023 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,05696815 0,10464149 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05696815 0,10456287 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05696815 0,10448437 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05696815 0,10440599 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05696815 0,10432773 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05696815 0,10424958 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05696815 0,10417155 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,05696815 0,10409363 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,05696815 0,10401583 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05696815 0,10393815 ! UV protection GO:0009650 20 11 0,000 0,05696815 0,10386059 ! adult heart development GO:0007512 16 11 0,000 0,05696815 0,10378314 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,05696815 0,1037058 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05696815 0,10362858 ! macroautophagy GO:0016236 19 11 0,000 0,05696815 0,10355148 ! temperature homeostasis GO:0001659 18 11 0,000 0,05696815 0,10347449 ! behavioral fear response GO:0001662 27 11 0,000 0,05696815 0,10339761 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05696815 0,10332085 ! negative regulation of ossification GO:0030279 27 11 0,000 0,05696815 0,1032442 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,05696815 0,10316767 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05696815 0,10309125 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,05696815 0,10301494 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,05696815 0,10293875 ! regulation of organ growth GO:0046620 14 11 0,000 0,05696815 0,10286267 ! pigment granule localization GO:0051875 20 11 0,000 0,05696815 0,1027867 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,05696815 0,10271084 ! vasoconstriction GO:0042310 20 11 0,000 0,05696815 0,10263509 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05696815 0,10255946 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05696815 0,10248394 ! embryonic axis specification GO:0000578 19 11 0,000 0,05696815 0,10240853 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05696815 0,10233323 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05696815 0,10225804 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05696815 0,10218296 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05696815 0,10210799 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05696815 0,10203313 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05696815 0,10195838 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05696815 0,10188374 ! prophase GO:0051324 17 11 0,000 0,05696815 0,10180921 ! neuroblast proliferation GO:0007405 25 11 0,000 0,05696815 0,10173479 ! nucleosome positioning GO:0016584 15 11 0,000 0,05696815 0,10166047 ! regulation of isotype switching GO:0045191 24 11 0,000 0,05696815 0,10158627 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05696815 0,10151217 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05696815 0,10143818 ! apical protein localization GO:0045176 18 11 0,000 0,05696815 0,1013643 ! acid secretion GO:0046717 20 11 0,000 0,05696815 0,10129053 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05696815 0,10121686 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05696815 0,1011433 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,05696815 0,10106985 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05696815 0,10099651 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,05696815 0,10092327 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05696815 0,10085013 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,05696815 0,10077711 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05696815 0,10070419 ! oocyte development GO:0048599 20 11 0,000 0,05696815 0,10063137 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,05696815 0,10055866 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,05696815 0,10048606 ! embryonic gut development GO:0048566 19 11 0,000 0,05696815 0,10041355 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05696815 0,10034116 ! activation of innate immune response GO:0002218 16 11 0,000 0,05696815 0,10026887 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05696815 0,10019668 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05696815 0,10012459 ! lysogeny GO:0030069 22 11 0,000 0,05696815 0,10005261 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05696815 0,09998074 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,05696815 0,09990896 ! sequestering of metal ion GO:0051238 15 11 0,000 0,05696815 0,09983729 ! nucleus localization GO:0051647 22 11 0,000 0,05696815 0,09976572 ! appendage development GO:0048736 151 73 1,000 0,05780959 0,10116678 GO:0060173|limb development, ! regulation of immune effector process GO:0002697 156 73 1,000 0,05780959 0,10109437 ! amino acid transport GO:0006865 148 74 1,000 0,05921338 0,10347518 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,05921338 0,10340121 ! negative regulation of transferase activity GO:0051348 155 74 1,000 0,05921338 0,10332736 ! respiratory system development GO:0060541 175 74 1,000 0,05921338 0,1032536 ! organelle localization GO:0051640 155 74 1,000 0,05921338 0,10317996 ! reproductive structure development GO:0048608 131 75 1,000 0,06062891 0,10557122 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,06062891 0,10549602 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,06062891 0,10542094 ! eye development GO:0001654 155 75 1,000 0,06062891 0,10534596 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06198413 0,10762419 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06198413 0,10754776 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,06198413 0,10747143 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06198413 0,10739521 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,06198413 0,10731909 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,06198413 0,10724309 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,06198413 0,10716719 ! protein complex disassembly GO:0043241 28 12 0,000 0,06198413 0,1070914 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06198413 0,10701572 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,06198413 0,10694014 ! hippocampus development GO:0021766 29 12 0,000 0,06198413 0,10686467 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06198413 0,10678931 ! T cell proliferation GO:0042098 32 12 0,000 0,06198413 0,10671405 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06198413 0,1066389 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06198413 0,10656386 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06198413 0,10648892 ! drug transport GO:0015893 16 12 0,000 0,06198413 0,10641408 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06198413 0,10633935 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06198413 0,10626473 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06198413 0,10619021 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06198413 0,10611579 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06198413 0,10604148 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06198413 0,10596728 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06198413 0,10589317 ! lipid digestion GO:0044241 21 12 0,000 0,06198413 0,10581917 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06198413 0,10574528 ! entry into host cell GO:0030260 34 12 0,000 0,06198413 0,10567149 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06198413 0,1055978 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06198413 0,10552421 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06198413 0,10545072 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06198413 0,10537734 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06198413 0,10530406 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06198413 0,10523088 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06198413 0,10515781 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06198413 0,10508483 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06198413 0,10501196 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06198413 0,10493918 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06198413 0,10486651 ! cranial nerve development GO:0021545 23 12 0,000 0,06198413 0,10479394 ! fucose catabolic process GO:0019317 25 12 0,000 0,06198413 0,10472147 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06198413 0,10464909 ! histone acetylation GO:0016573 27 12 0,000 0,06198413 0,10457682 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,06198413 0,10450465 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06198413 0,10443258 ! zymogen activation GO:0031638 18 12 0,000 0,06198413 0,10436061 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,06198413 0,10428873 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06198413 0,10421696 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06198413 0,10414528 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,06198413 0,1040737 ! oocyte differentiation GO:0009994 21 12 0,000 0,06198413 0,10400222 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06198413 0,10393084 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,06198413 0,10385956 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,06198413 0,10378838 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06198413 0,10371729 ! defense response to fungus GO:0050832 15 12 0,000 0,06198413 0,1036463 ! developmental induction GO:0031128 22 12 0,000 0,06198413 0,1035754 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,06198413 0,10350461 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06198413 0,10343391 ! response to cold GO:0009409 17 12 0,000 0,06198413 0,1033633 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06198413 0,1032928 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06198413 0,10322239 ! localization within membrane GO:0051668 26 12 0,000 0,06198413 0,10315207 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,06205599 0,10320135 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,06205599 0,10313115 ! regulation of blood pressure GO:0008217 134 76 1,000 0,06205599 0,10306104 ! amine catabolic process GO:0009310 136 77 1,000 0,06349448 0,10537841 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,06349448 0,10530687 ! antigen processing and presentation GO:0019882 117 78 1,000 0,06494421 0,10763821 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,06494421 0,10756523 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,06640503 0,10991022 ! protein oligomerization GO:0051259 149 79 1,000 0,06640503 0,10983581 ! regulation of synaptic transmission GO:0050804 159 79 1,000 0,06640503 0,1097615 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,06697358 0,11062641 ! cGMP metabolic process GO:0046068 18 13 0,000 0,06697358 0,11055166 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,06697358 0,11047701 ! regulation of chemokine production GO:0032642 18 13 0,000 0,06697358 0,11040247 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,06697358 0,11032802 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,06697358 0,11025368 ! peroxisomal transport GO:0043574 28 13 0,000 0,06697358 0,11017943 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,06697358 0,11010529 ! cartilage condensation GO:0001502 22 13 0,000 0,06697358 0,11003124 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,06697358 0,1099573 ! organelle fusion GO:0048284 36 13 0,000 0,06697358 0,10988345 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,06697358 0,1098097 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,06697358 0,10973605 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,06697358 0,1096625 ! endocrine pancreas development GO:0031018 25 13 0,000 0,06697358 0,10958905 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,06697358 0,1095157 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,06697358 0,10944245 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,06697358 0,10936929 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,06697358 0,10929623 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,06697358 0,10922327 ! methionine metabolic process GO:0006555 31 13 0,000 0,06697358 0,1091504 ! plasma membrane organization GO:0007009 27 13 0,000 0,06697358 0,10907764 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,06697358 0,10900497 ! Golgi organization GO:0007030 25 13 0,000 0,06697358 0,10893239 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,06697358 0,10885992 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,06697358 0,10878754 ! cytokine metabolic process GO:0042107 24 13 0,000 0,06697358 0,10871525 ! asymmetric protein localization GO:0008105 24 13 0,000 0,06697358 0,10864307 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,06697358 0,10857097 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,06697358 0,10849898 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,06697358 0,10842707 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,06697358 0,10835527 ! protein homotetramerization GO:0051289 24 13 0,000 0,06697358 0,10828356 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,06697358 0,10821194 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,06697358 0,10814042 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,06697358 0,10806899 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,06697358 0,10799766 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,06697358 0,10792642 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,06697358 0,10785528 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,06697358 0,10778423 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,06697358 0,10771327 ! histone methylation GO:0016571 29 13 0,000 0,06697358 0,10764241 ! chromatin silencing GO:0006342 29 13 0,000 0,06697358 0,10757163 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,06697358 0,10750096 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,06697358 0,10743037 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,06697358 0,10735988 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,06697358 0,10728948 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,06697358 0,10721917 ! spleen development GO:0048536 24 13 0,000 0,06697358 0,10714896 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,06697358 0,10707883 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,06697358 0,1070088 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,06697358 0,10693886 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,06697358 0,10686901 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,06697358 0,10679925 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,06697358 0,10672959 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,06697358 0,10666001 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,06697358 0,10659053 ! insulin secretion GO:0030073 24 13 0,000 0,06697358 0,10652113 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,06697358 0,10645183 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,06697358 0,10638261 ! acrosome reaction GO:0007340 19 13 0,000 0,06697358 0,10631349 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,06697358 0,10624445 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,06697358 0,10617551 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,06935929 0,10988635 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,07085242 0,11217918 ! rRNA transcription GO:0009303 28 14 0,000 0,07193663 0,11382201 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07193663 0,11374834 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,07193663 0,11367476 ! water transport GO:0006833 21 14 0,000 0,07193663 0,11360128 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07193663 0,11352789 ! non-recombinational repair GO:0000726 29 14 0,000 0,07193663 0,1134546 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07193663 0,11338141 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07193663 0,1133083 ! RNA polyadenylation GO:0043631 32 14 0,000 0,07193663 0,1132353 ! lipid localization GO:0010876 32 14 0,000 0,07193663 0,11316238 GO:0019915|lipid storage, ! regulated secretory pathway GO:0045055 24 14 0,000 0,07193663 0,11308956 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07193663 0,11301683 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07193663 0,1129442 ! arginine metabolic process GO:0006525 21 14 0,000 0,07193663 0,11287166 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07193663 0,11279922 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,07193663 0,11272686 ! regulation of heart rate GO:0002027 25 14 0,000 0,07193663 0,1126546 ! fear response GO:0042596 34 14 0,000 0,07193663 0,11258243 ! organic alcohol transport GO:0015850 29 14 0,000 0,07193663 0,11251036 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07193663 0,11243837 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,07193663 0,11236648 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,07193663 0,11229468 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07193663 0,11222297 ! bone mineralization GO:0030282 18 14 0,000 0,07193663 0,11215136 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07193663 0,11207983 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,07193663 0,1120084 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07193663 0,11193706 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,07193663 0,1118658 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07193663 0,11179464 ! regulation of cellular pH GO:0030641 27 14 0,000 0,07193663 0,11172357 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07193663 0,11165259 ! ribosome assembly GO:0042255 18 14 0,000 0,07193663 0,1115817 ! cerebellum development GO:0021549 23 14 0,000 0,07193663 0,1115109 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07193663 0,11144019 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07193663 0,11136957 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07193663 0,11129904 ! response to gamma radiation GO:0010332 30 14 0,000 0,07193663 0,11122859 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07193663 0,11115824 ! NADP metabolic process GO:0006739 24 14 0,000 0,07193663 0,11108798 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,07193663 0,1110178 ! oxygen transport GO:0015671 22 14 0,000 0,07193663 0,11094771 ! male genitalia development GO:0030539 26 14 0,000 0,07193663 0,11087771 ! regulation of RNA stability GO:0043487 33 14 0,000 0,07193663 0,1108078 ! regulation of axon extension GO:0030516 43 14 0,000 0,07193663 0,11073798 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,07193663 0,11066825 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07193663 0,1105986 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,07193663 0,11052904 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,07235602 0,11110355 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of transmission of nerve impulse GO:0051969 167 85 1,000 0,07539399 0,11569567 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,07687341 0,11789187 ! lactation GO:0007595 30 15 0,000 0,07687341 0,11781791 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,07687341 0,11774404 ! reproductive cellular process GO:0048610 22 15 0,000 0,07687341 0,11767027 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,07687341 0,11759658 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,07687341 0,11752299 ! superoxide anion generation GO:0042554 22 15 0,000 0,07687341 0,1174495 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,07687341 0,11737609 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,07687341 0,11730278 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,07687341 0,11722955 ! copper ion transport GO:0006825 22 15 0,000 0,07687341 0,11715642 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,07687341 0,11708338 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,07687341 0,11701043 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,07687341 0,11693757 ! sulfate transport GO:0008272 27 15 0,000 0,07687341 0,11686481 ! response to cAMP GO:0051591 25 15 0,000 0,07687341 0,11679213 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,07687341 0,11671954 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,07687341 0,11664705 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,07687341 0,11657464 ! response to hexose stimulus GO:0009746 25 15 0,000 0,07687341 0,11650232 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,07687341 0,1164301 ! vesicle coating GO:0006901 38 15 0,000 0,07687341 0,11635796 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,07687341 0,11628591 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,07687341 0,11621395 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,07687341 0,11614208 ! regulation of exocytosis GO:0017157 26 15 0,000 0,07687341 0,1160703 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,07687341 0,11599861 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,07687341 0,115927 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,07687341 0,11585549 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,07687341 0,11578406 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,07687341 0,11571272 ! regulation of vasodilation GO:0042312 27 15 0,000 0,07687341 0,11564147 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,07687341 0,1155703 ! histone deacetylation GO:0016575 24 15 0,000 0,07687341 0,11549923 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,07687341 0,11542824 ! water homeostasis GO:0030104 28 15 0,000 0,07687341 0,11535734 ! cofactor transport GO:0051181 30 15 0,000 0,07687341 0,11528652 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,07687341 0,11521579 ! muscle maintenance GO:0046716 26 15 0,000 0,07687341 0,11514515 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,07687341 0,1150746 ! intestinal absorption GO:0050892 31 15 0,000 0,07687341 0,11500413 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,07687341 0,11493375 ! heme biosynthetic process GO:0006783 33 15 0,000 0,07687341 0,11486345 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,07687341 0,11479324 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,07687341 0,11472312 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,07687341 0,11465308 ! actin filament polymerization GO:0030041 27 15 0,000 0,07687341 0,11458313 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,07687341 0,11451326 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,07692806 0,11452484 GO:0002696|positive regulation of leukocyte activation, ! alcohol catabolic process GO:0046164 142 87 1,000 0,078472 0,11675219 ! amine biosynthetic process GO:0009309 146 88 1,000 0,08002565 0,11899128 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,08002565 0,1189189 ! regulation of neurological system process GO:0031644 175 89 1,000 0,08158888 0,12116816 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,08178407 0,12138426 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,08178407 0,12131056 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,08178407 0,12123695 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,08178407 0,12116343 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,08178407 0,12109 ! bone remodeling GO:0046849 28 16 0,000 0,08178407 0,12101665 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,08178407 0,1209434 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,08178407 0,12087023 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08178407 0,12079715 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,08178407 0,12072416 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,08178407 0,12065126 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,08178407 0,12057845 ! startle response GO:0001964 28 16 0,000 0,08178407 0,12050573 ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,08178407 0,12043309 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,08178407 0,12036054 ! protein polyubiquitination GO:0000209 41 16 0,000 0,08178407 0,12028807 ! glutamate metabolic process GO:0006536 25 16 0,000 0,08178407 0,1202157 ! pituitary gland development GO:0021983 30 16 0,000 0,08178407 0,12014341 ! response to osmotic stress GO:0006970 27 16 0,000 0,08178407 0,12007121 ! lysosomal transport GO:0007041 31 16 0,000 0,08178407 0,11999909 ! fructose metabolic process GO:0006000 25 16 0,000 0,08178407 0,11992707 ! L-amino acid transport GO:0015807 33 16 0,000 0,08178407 0,11985512 ! stem cell development GO:0048864 46 16 0,000 0,08178407 0,11978327 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08178407 0,1197115 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 36 16 0,000 0,08178407 0,11963982 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,08178407 0,11956822 ! axon cargo transport GO:0008088 46 16 0,000 0,08178407 0,11949671 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,08178407 0,11942528 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,08178407 0,11935394 ! DNA replication initiation GO:0006270 28 16 0,000 0,08178407 0,11928268 ! mRNA splice site selection GO:0006376 44 16 0,000 0,08178407 0,11921151 ! tissue regeneration GO:0042246 27 16 0,000 0,08178407 0,11914042 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,08178407 0,11906942 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,08178407 0,11899851 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,08178407 0,11892767 ! biomineral formation GO:0031214 22 16 0,000 0,08178407 0,11885693 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,08178407 0,11878626 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,08178407 0,11871568 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,08178407 0,11864519 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08178407 0,11857477 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,08178407 0,11850444 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,08178407 0,1184342 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,08178407 0,11836404 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,08178407 0,11829396 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 27 16 0,000 0,08178407 0,11822396 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,08316153 0,12014406 ! defense response to bacterium GO:0042742 112 91 1,000 0,08474346 0,12235713 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,08666875 0,12506306 ! metencephalon development GO:0022037 32 17 0,000 0,08666875 0,12498923 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,08666875 0,12491549 ! signal complex assembly GO:0007172 47 17 0,000 0,08666875 0,12484184 ! filopodium assembly GO:0046847 42 17 0,000 0,08666875 0,12476827 ! endothelial cell migration GO:0043542 31 17 0,000 0,08666875 0,12469479 ! gene silencing by RNA GO:0031047 38 17 0,000 0,08666875 0,1246214 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,08666875 0,12454809 ! glial cell development GO:0021782 28 17 0,000 0,08666875 0,12447487 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,08666875 0,12440174 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,08666875 0,12432869 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,08666875 0,12425573 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,08666875 0,12418285 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,08666875 0,12411006 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,08666875 0,12403735 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,08666875 0,12396473 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,08666875 0,12389219 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,08666875 0,12381974 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,08666875 0,12374738 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,08666875 0,12367509 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,08666875 0,12360289 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,08666875 0,12353078 ! membrane budding GO:0006900 42 17 0,000 0,08666875 0,12345875 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,08666875 0,12338681 ! regulation of protein binding GO:0043393 33 17 0,000 0,08666875 0,12331494 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,08666875 0,12324317 ! genitalia development GO:0048806 32 17 0,000 0,08666875 0,12317147 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,08666875 0,12309986 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,08666875 0,12302833 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,08666875 0,12295689 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,08666875 0,12288552 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,08666875 0,12281425 ! steroid catabolic process GO:0006706 34 17 0,000 0,08666875 0,12274305 ! gas transport GO:0015669 26 17 0,000 0,08666875 0,12267193 ! organic cation transport GO:0015695 32 17 0,000 0,08666875 0,1226009 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,08666875 0,12252995 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,08666875 0,12245909 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,08666875 0,1223883 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,0879346 0,12410411 ! amine transport GO:0015837 181 93 1,000 0,0879346 0,12403246 ! positive regulation of MAP kinase activity GO:0043406 174 93 1,000 0,0879346 0,12396089 ! nitrogen compound catabolic process GO:0044270 167 94 1,000 0,08954353 0,12615619 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,08954353 0,12608348 ! regulation of defense response GO:0031347 171 95 1,000 0,09116118 0,12828731 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,09152758 0,12872877 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,09152758 0,1286547 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,09152758 0,12858072 ! limbic system development GO:0021761 40 18 0,000 0,09152758 0,12850683 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,09152758 0,12843301 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,09152758 0,12835929 ! adult walking behavior GO:0007628 36 18 0,000 0,09152758 0,12828564 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,09152758 0,12821209 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,09152758 0,12813861 ! centrosome cycle GO:0007098 26 18 0,000 0,09152758 0,12806522 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,09152758 0,12799192 ! glutamine metabolic process GO:0006541 29 18 0,000 0,09152758 0,12791869 ! response to retinoic acid GO:0032526 31 18 0,000 0,09152758 0,12784556 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 0,000 0,09152758 0,1277725 ! DNA integration GO:0015074 32 18 0,000 0,09152758 0,12769953 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,09152758 0,12762664 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,09152758 0,12755384 ! neural crest cell migration GO:0001755 41 18 0,000 0,09152758 0,12748112 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,09152758 0,12740848 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,09152758 0,12733592 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,09152758 0,12726345 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,09152758 0,12719106 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,09152758 0,12711875 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,09152758 0,12704652 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,09152758 0,12697438 ! nerve development GO:0021675 34 18 0,000 0,09152758 0,12690231 ! microspike assembly GO:0030035 46 18 0,000 0,09152758 0,12683033 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,09152758 0,12675843 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,09152758 0,12668662 ! regulation of T cell activation GO:0050863 175 96 1,000 0,09278742 0,12835768 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,0944221 0,1305451 ! leukocyte differentiation GO:0002521 232 98 1,000 0,0960651 0,13274154 ! interphase of mitotic cell cycle GO:0051329 224 98 1,000 0,0960651 0,13266651 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,0963607 0,13299954 ! positive regulation of translation GO:0045727 31 19 0,000 0,0963607 0,13292444 ! negative regulation of defense response GO:0031348 27 19 0,000 0,0963607 0,13284942 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,0963607 0,1327745 ! neuron maturation GO:0042551 46 19 0,000 0,0963607 0,13269965 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,0963607 0,13262489 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,0963607 0,13255021 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,0963607 0,13247562 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,0963607 0,13240111 ! inositol metabolic process GO:0006020 33 19 0,000 0,0963607 0,13232669 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,0963607 0,13225235 ! memory GO:0007613 34 19 0,000 0,0963607 0,13217809 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,0963607 0,13210392 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,0963607 0,13202983 GO:0042744|hydrogen peroxide catabolic process, ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,0963607 0,13195582 ! cerebral cortex development GO:0021987 40 19 0,000 0,0963607 0,13188189 ! pigmentation during development GO:0048066 42 19 0,000 0,0963607 0,13180805 ! response to vitamin A GO:0033189 32 19 0,000 0,0963607 0,13173429 ! heme metabolic process GO:0042168 40 19 0,000 0,0963607 0,13166062 ! neuromuscular junction development GO:0007528 43 19 0,000 0,0963607 0,13158702 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,0963607 0,13151351 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,0963607 0,13144008 ! response to fungus GO:0009620 26 19 0,000 0,0963607 0,13136673 ! peptide cross-linking GO:0018149 39 19 0,000 0,0963607 0,13129346 ! heart process GO:0003015 32 19 0,000 0,0963607 0,13122028 GO:0060047|heart contraction, ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,0963607 0,13114718 ! visual learning GO:0008542 38 19 0,000 0,0963607 0,13107415 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,0963607 0,13100121 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,0963607 0,13092835 ! vitamin transport GO:0051180 31 19 0,000 0,0963607 0,13085558 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,0963607 0,13078288 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,0963607 0,13071026 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,0963607 0,13063772 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,0963607 0,13056527 ! cilium assembly GO:0042384 38 19 0,000 0,0963607 0,13049289 ! peptide hormone secretion GO:0030072 32 19 0,000 0,0963607 0,1304206 ! positive regulation of immune response GO:0050778 175 100 1,000 0,09937552 0,13442657 ! hormone metabolic process GO:0042445 171 100 1,000 0,09937552 0,13435218 ! protein secretion GO:0009306 45 20 0,000 0,10116824 0,13670022 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,10116824 0,13662465 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,10116824 0,13654917 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,10116824 0,13647377 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,10116824 0,13639845 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,10116824 0,13632322 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,10116824 0,13624807 ! response to vitamin GO:0033273 36 20 0,000 0,10116824 0,136173 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,10116824 0,13609802 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,10116824 0,13602311 GO:0010675|regulation of cellular carbohydrate metabolic process, ! bile acid metabolic process GO:0008206 34 20 0,000 0,10116824 0,13594829 ! retinoid metabolic process GO:0001523 34 20 0,000 0,10116824 0,13587356 GO:0016101|diterpenoid metabolic process, ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,10116824 0,1357989 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,10116824 0,13572433 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,10116824 0,13564983 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,10116824 0,13557542 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,10116824 0,1355011 ! body fluid secretion GO:0007589 33 20 0,000 0,10116824 0,13542685 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,10116824 0,13535268 ! peptide secretion GO:0002790 38 20 0,000 0,10116824 0,1352786 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,10116824 0,13520459 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,10116824 0,13513067 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,10116824 0,13505683 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,10116824 0,13498307 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,10116824 0,13490939 ! cell-cell junction organization GO:0045216 43 20 0,000 0,10116824 0,13483579 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,10116824 0,13476227 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,10116824 0,13468883 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,10116824 0,13461547 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,10116824 0,13454219 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,10116824 0,13446899 ! regulation of glucose import GO:0046324 30 20 0,000 0,10116824 0,13439587 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,10116824 0,13432283 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,10116824 0,13424986 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,10116824 0,13417698 ! negative regulation of translation GO:0017148 32 20 0,000 0,10116824 0,13410418 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,10116824 0,13403145 ! regulation of cell killing GO:0031341 46 21 0,000 0,10595033 0,14029087 ! hormone secretion GO:0046879 39 21 0,000 0,10595033 0,14021488 ! lipid phosphorylation GO:0046834 43 21 0,000 0,10595033 0,14013896 ! cAMP metabolic process GO:0046058 41 21 0,000 0,10595033 0,14006313 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,10595033 0,13998738 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,10595033 0,13991171 ! ovarian follicle development GO:0001541 39 21 0,000 0,10595033 0,13983612 ! smooth muscle contraction GO:0006939 48 21 0,000 0,10595033 0,13976062 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 0,000 0,10595033 0,13968519 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,10595033 0,13960985 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,10595033 0,13953459 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,10595033 0,13945941 ! plasma membrane fusion GO:0045026 33 21 0,000 0,10595033 0,13938431 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,10595033 0,13930929 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,10595033 0,13923435 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,10595033 0,13915949 ! diencephalon development GO:0021536 36 21 0,000 0,10595033 0,13908472 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,10595033 0,13901002 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,10595033 0,13893541 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,10595033 0,13886087 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,10595033 0,13878641 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,10595033 0,13871204 ! collagen catabolic process GO:0030574 29 21 0,000 0,10595033 0,13863774 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,10595033 0,13856352 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,10595033 0,13848939 ! sperm-egg recognition GO:0035036 23 21 0,000 0,10595033 0,13841533 ! actin filament-based movement GO:0030048 47 21 0,000 0,10595033 0,13834135 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,10595033 0,13826745 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,11070712 0,14439802 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,11070712 0,14432097 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,11070712 0,144244 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,11070712 0,14416711 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,11070712 0,1440903 ! microtubule-based transport GO:0010970 59 22 0,000 0,11070712 0,14401358 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,11070712 0,14393693 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,11070712 0,14386037 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,11070712 0,14378389 ! vacuolar transport GO:0007034 41 22 0,000 0,11070712 0,14370749 ! central nervous system neuron development GO:0021954 47 22 0,000 0,11070712 0,14363117 ! fucose metabolic process GO:0006004 44 22 0,000 0,11070712 0,14355493 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,11070712 0,14347878 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,11070712 0,1434027 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,11070712 0,14332671 ! ureteric bud development GO:0001657 50 22 0,000 0,11070712 0,14325079 ! cell aging GO:0007569 48 22 0,000 0,11070712 0,14317496 ! stem cell differentiation GO:0048863 57 22 0,000 0,11070712 0,1430992 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,11070712 0,14302353 ! cytolysis GO:0019835 27 22 0,000 0,11070712 0,14294794 ! renal system process GO:0003014 42 22 0,000 0,11070712 0,14287242 ! vasodilation GO:0042311 40 22 0,000 0,11070712 0,14279699 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,11070712 0,14272163 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,11070712 0,14264636 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,11070712 0,14257116 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,11070712 0,14249605 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,11070712 0,14242101 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,11070712 0,14234605 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,11070712 0,14227117 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,11070712 0,14219637 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,11070712 0,14212165 ! sarcomere organization GO:0045214 32 22 0,000 0,11070712 0,142047 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,11070712 0,14197244 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,11070712 0,14189795 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,11070712 0,14182354 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,11070712 0,14174921 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,11070712 0,14167496 ! gut development GO:0048565 44 22 0,000 0,11070712 0,14160078 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,11070712 0,14152668 ! protein stabilization GO:0050821 41 22 0,000 0,11070712 0,14145266 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,11543873 0,14742124 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,11543873 0,14734421 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,11543873 0,14726727 ! viral genome replication GO:0019079 44 23 0,000 0,11543873 0,14719041 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,11543873 0,14711363 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,11543873 0,14703693 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,11543873 0,1469603 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,11543873 0,14688376 ! axis specification GO:0009798 43 23 0,000 0,11543873 0,1468073 ! visual behavior GO:0007632 46 23 0,000 0,11543873 0,14673092 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,11543873 0,14665461 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,11543873 0,14657839 ! response to ethanol GO:0045471 47 23 0,000 0,11543873 0,14650225 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,11543873 0,14642618 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,11543873 0,14635019 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,11543873 0,14627429 ! peroxisome organization GO:0007031 43 23 0,000 0,11543873 0,14619846 ! lysosome organization GO:0007040 47 23 0,000 0,11543873 0,14612271 ! vesicle targeting GO:0006903 49 23 0,000 0,11543873 0,14604703 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,11543873 0,14597144 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,11543873 0,14589593 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,11543873 0,14582049 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,11543873 0,14574513 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,11543873 0,14566985 ! fatty acid transport GO:0015908 47 23 0,000 0,11543873 0,14559464 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,11543873 0,14551952 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,11543873 0,14544447 ! hormone transport GO:0009914 41 23 0,000 0,11543873 0,1453695 ! cell-cell recognition GO:0009988 28 23 0,000 0,11543873 0,1452946 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,11543873 0,14521979 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,11543873 0,14514505 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,11543873 0,14507038 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,1201453 0,15090744 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,1201453 0,15082989 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,1201453 0,15075243 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,1201453 0,15067504 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,1201453 0,15059773 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,1201453 0,1505205 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,1201453 0,15044335 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,1201453 0,15036628 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,1201453 0,15028929 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,1201453 0,15021237 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,1201453 0,15013554 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,1201453 0,15005878 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,1201453 0,1499821 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,1201453 0,1499055 ! sex determination GO:0007530 48 24 0,000 0,1201453 0,14982898 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,1201453 0,14975254 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,1201453 0,14967617 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,1201453 0,14959989 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,1201453 0,14952368 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,1201453 0,14944754 ! membrane depolarization GO:0051899 45 24 0,000 0,1201453 0,14937149 ! pallium development GO:0021543 56 24 0,000 0,1201453 0,14929551 ! oogenesis GO:0048477 44 24 0,000 0,1201453 0,14921961 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,1201453 0,14914379 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,1201453 0,14906804 ! platelet activation GO:0030168 41 24 0,000 0,1201453 0,14899237 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,1201453 0,14891678 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,1201453 0,14884127 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,1201453 0,14876583 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,1201453 0,14869046 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,1201453 0,14861518 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,1201453 0,14853997 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,12482696 0,15425001 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,12482696 0,15417203 ! leukocyte adhesion GO:0007159 55 25 0,000 0,12482696 0,15409412 ! phototransduction GO:0007602 37 25 0,000 0,12482696 0,1540163 ! keratinization GO:0031424 37 25 0,000 0,12482696 0,15393855 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,12482696 0,15386088 ! vacuole organization GO:0007033 49 25 0,000 0,12482696 0,15378329 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,12482696 0,15370578 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,12482696 0,15362835 ! receptor metabolic process GO:0043112 53 25 0,000 0,12482696 0,15355099 ! regulation of behavior GO:0050795 48 25 0,000 0,12482696 0,15347371 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,12482696 0,15339651 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,12482696 0,15331939 ! immunoglobulin production GO:0002377 62 25 0,000 0,12482696 0,15324235 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,12482696 0,15316538 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,12482696 0,15308849 ! liver development GO:0001889 55 25 0,000 0,12482696 0,15301168 ! protein tetramerization GO:0051262 57 25 0,000 0,12482696 0,15293494 ! myelination GO:0042552 50 26 0,000 0,12948384 0,15856092 ! initiation of viral infection GO:0019059 60 26 0,000 0,12948384 0,15848148 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,12948384 0,15840212 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,12948384 0,15832284 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,12948384 0,15824363 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,12948384 0,15816451 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,12948384 0,15808547 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,12948384 0,15800651 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,12948384 0,15792762 ! digestive system process GO:0022600 49 26 0,000 0,12948384 0,15784882 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,12948384 0,15777009 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,12948384 0,15769144 ! osteoblast differentiation GO:0001649 63 26 0,000 0,12948384 0,15761287 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,12948384 0,15753438 ! neural crest cell development GO:0014032 59 26 0,000 0,12948384 0,15745596 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,12948384 0,15737762 ! negative regulation of cell development GO:0010721 83 26 0,000 0,12948384 0,15729937 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,12948384 0,15722119 ! pentose metabolic process GO:0019321 43 26 0,000 0,12948384 0,15714308 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,12948384 0,15706506 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,12948384 0,15698711 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,12948384 0,15690924 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,12948384 0,15683145 ! blastocyst development GO:0001824 50 26 0,000 0,12948384 0,15675373 ! telomere organization GO:0032200 46 26 0,000 0,12948384 0,15667609 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,12948384 0,15659853 ! neural tube closure GO:0001843 58 26 0,000 0,12948384 0,15652104 GO:0060606|tube closure, ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,12948384 0,15644363 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,13411607 0,16196024 ! embryonic pattern specification GO:0009880 49 27 0,000 0,13411607 0,16188022 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,13411607 0,16180028 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,13411607 0,16172042 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,13411607 0,16164063 ! iron ion transport GO:0006826 65 27 0,000 0,13411607 0,16156093 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,13411607 0,1614813 ! superoxide metabolic process GO:0006801 41 27 0,000 0,13411607 0,16140176 ! tube lumen formation GO:0035148 59 27 0,000 0,13411607 0,16132229 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,13411607 0,1612429 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,13411607 0,16116358 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,13411607 0,16108435 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,13411607 0,16100519 ! response to toxin GO:0009636 49 27 0,000 0,13411607 0,16092611 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,13411607 0,16084711 ! leukocyte proliferation GO:0070661 59 27 0,000 0,13411607 0,16076819 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,13411607 0,16068934 ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,13872378 0,16612853 ! neuron fate commitment GO:0048663 52 28 0,000 0,13872378 0,16604713 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,13872378 0,16596582 ! protein amino acid acylation GO:0043543 59 28 0,000 0,13872378 0,16588458 ! vesicle docking GO:0048278 55 28 0,000 0,13872378 0,16580343 ! circadian rhythm GO:0007623 56 28 0,000 0,13872378 0,16572235 ! dendrite development GO:0016358 67 28 0,000 0,13872378 0,16564135 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,13872378 0,16556043 ! sperm motility GO:0030317 37 28 0,000 0,13872378 0,16547959 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,13872378 0,16539883 ! base-excision repair GO:0006284 41 28 0,000 0,13872378 0,16531815 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,13872378 0,16523754 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,13872378 0,16515702 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,13872378 0,16507657 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,13872378 0,1649962 ! glutathione metabolic process GO:0006749 42 28 0,000 0,13872378 0,16491591 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,13872378 0,1648357 ! lipid oxidation GO:0034440 48 28 0,000 0,13872378 0,16475557 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,13872378 0,16467551 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,1433071 0,17003363 ! translational initiation GO:0006413 66 29 0,000 0,1433071 0,16995109 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,1433071 0,16986863 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,1433071 0,16978625 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,1433071 0,16970395 ! autophagy GO:0006914 47 29 0,000 0,1433071 0,16962173 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,1433071 0,16953959 ! primary neural tube formation GO:0014020 61 29 0,000 0,1433071 0,16945753 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,1433071 0,16937555 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,1433071 0,16929364 ! somitogenesis GO:0001756 52 29 0,000 0,1433071 0,16921182 ! synaptogenesis GO:0007416 46 29 0,000 0,1433071 0,16913007 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,1433071 0,16904841 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,1433071 0,16896682 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,1433071 0,16888531 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,1433071 0,16880388 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,14786616 0,17409014 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,14786616 0,17400628 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,14786616 0,1739225 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,14786616 0,1738388 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,14786616 0,17375519 ! acute-phase response GO:0006953 50 30 0,000 0,14786616 0,17367165 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,14786616 0,17358819 ! myofibril assembly GO:0030239 50 30 0,000 0,14786616 0,17350482 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,14786616 0,17342152 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,14786616 0,17333831 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,14786616 0,17325517 ! cell fate determination GO:0001709 64 30 0,000 0,14786616 0,17317212 ! phospholipid transport GO:0015914 65 30 0,000 0,14786616 0,17308914 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,14786616 0,17300624 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,14786616 0,17292342 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,14786616 0,17284069 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,14786616 0,17275803 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,14786616 0,17267545 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,14786616 0,17259294 ! regulation of coagulation GO:0050818 52 30 0,000 0,14786616 0,17251052 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,15240109 0,1777164 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,15240109 0,17763161 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,15240109 0,1775469 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,15240109 0,17746227 ! regulation of innate immune response GO:0045088 57 31 0,000 0,15240109 0,17737773 ! ovulation cycle process GO:0022602 55 31 0,000 0,15240109 0,17729326 ! peptide transport GO:0015833 60 31 0,000 0,15240109 0,17720888 ! male gonad development GO:0008584 56 31 0,000 0,15240109 0,17712457 ! iron ion homeostasis GO:0055072 60 31 0,000 0,15240109 0,17704035 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,15240109 0,1769562 ! detection of light stimulus GO:0009583 44 31 0,000 0,15240109 0,17687214 ! natural killer cell activation GO:0030101 50 31 0,000 0,15240109 0,17678815 ! ensheathment of neurons GO:0007272 64 31 0,000 0,15240109 0,17670425 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,15240109 0,17662042 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,15240109 0,17653668 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,15240109 0,17645301 ! eye morphogenesis GO:0048592 65 31 0,000 0,15240109 0,17636942 ! response to heat GO:0009408 54 31 0,000 0,15240109 0,17628591 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,15240109 0,17620249 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,156912 0,18133208 ! collagen metabolic process GO:0032963 49 32 0,000 0,156912 0,18124635 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,156912 0,18116069 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,156912 0,18107512 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,156912 0,18098962 ! metanephros development GO:0001656 81 32 0,000 0,156912 0,18090421 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,156912 0,18081888 ! muscle cell development GO:0055001 52 32 0,000 0,156912 0,18073363 ! mesoderm formation GO:0001707 73 32 0,000 0,156912 0,18064846 ! ovulation cycle GO:0042698 57 32 0,000 0,156912 0,18056336 ! peripheral nervous system development GO:0007422 68 32 0,000 0,156912 0,18047835 ! BMP signaling pathway GO:0030509 71 32 0,000 0,156912 0,18039342 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,156912 0,18030857 ! gene silencing GO:0016458 71 32 0,000 0,156912 0,1802238 ! regulation of pH GO:0006885 56 33 0,000 0,16139904 0,18529034 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,16139904 0,18520331 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,16139904 0,18511636 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,16139904 0,18502949 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,16139904 0,18494271 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,16139904 0,184856 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,16139904 0,18476938 ! response to ionizing radiation GO:0010212 74 33 0,000 0,16139904 0,18468283 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,16139904 0,18459637 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,16139904 0,18450999 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,16139904 0,18442369 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,16139904 0,18433747 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,16139904 0,18425133 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,16139904 0,18416527 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,16586232 0,18916977 ! glial cell differentiation GO:0010001 67 34 0,000 0,16586232 0,1890815 ! post-embryonic development GO:0009791 76 34 0,000 0,16586232 0,18899331 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,16586232 0,1889052 ! cholesterol transport GO:0030301 62 34 0,000 0,16586232 0,18881717 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,16586232 0,18872923 ! spliceosome assembly GO:0000245 75 34 0,000 0,16586232 0,18864136 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,16586232 0,18855358 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,16586232 0,18846588 ! formation of primary germ layer GO:0001704 76 34 0,000 0,16586232 0,18837827 ! cell fate specification GO:0001708 56 34 0,000 0,16586232 0,18829073 ! adult locomotory behavior GO:0008344 62 34 0,000 0,16586232 0,18820327 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,17030197 0,19315121 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,17030197 0,19306159 ! negative regulation of secretion GO:0051048 68 35 0,000 0,17030197 0,19297204 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,17030197 0,19288258 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,17030197 0,1927932 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,17030197 0,1927039 ! membrane docking GO:0022406 69 35 0,000 0,17030197 0,19261468 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,17030197 0,19252555 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,17030197 0,1924365 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,17030197 0,19234753 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,17030197 0,19225865 ! ceramide metabolic process GO:0006672 72 35 0,000 0,17030197 0,19216985 ! telencephalon development GO:0021537 81 35 0,000 0,17030197 0,19208112 ! sterol transport GO:0015918 63 35 0,000 0,17030197 0,19199249 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,17030197 0,19190393 ! placenta development GO:0001890 53 35 0,000 0,17030197 0,19181545 ! vesicle localization GO:0051648 70 35 0,000 0,17030197 0,19172706 ! regulation of muscle development GO:0048634 82 36 0,000 0,17471812 0,19660818 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,17471812 0,19651766 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,17471812 0,19642723 ! protein targeting to membrane GO:0006612 75 36 0,000 0,17471812 0,19633687 ! regulation of proteolysis GO:0030162 77 36 0,000 0,17471812 0,1962466 ! aerobic respiration GO:0009060 56 36 0,000 0,17471812 0,19615642 ! cytokine production GO:0001816 68 36 0,000 0,17471812 0,19606631 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,17911088 0,20090353 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,17911088 0,20081133 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,17911088 0,20071921 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,17911088 0,20062718 ! actomyosin structure organization GO:0031032 68 37 0,000 0,17911088 0,20053524 ! tissue remodeling GO:0048771 78 37 0,000 0,17911088 0,20044337 ! female gonad development GO:0008585 71 37 0,000 0,17911088 0,2003516 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,17911088 0,2002599 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,17911088 0,20016829 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,18348039 0,20495774 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,18348039 0,20486407 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,18348039 0,20477048 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,18348039 0,20467698 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,18348039 0,20458356 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,18348039 0,20449023 ! regulation of protein stability GO:0031647 77 38 0,000 0,18348039 0,20439698 ! spermatid development GO:0007286 69 38 0,000 0,18348039 0,20430382 ! glycogen metabolic process GO:0005977 63 38 0,000 0,18348039 0,20421075 ! pigment metabolic process GO:0042440 87 38 0,000 0,18348039 0,20411775 ! neural tube formation GO:0001841 79 38 0,000 0,18348039 0,20402485 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,18782676 0,20876286 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,18782676 0,20866793 ! negative regulation of binding GO:0051100 71 39 0,000 0,18782676 0,20857308 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,18782676 0,20847831 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,18782676 0,20838364 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,18782676 0,20828905 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,18782676 0,20819454 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,18782676 0,20810012 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 0,000 0,18782676 0,20800579 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,19215011 0,2126972 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,19215011 0,21260087 ! learning GO:0007612 82 40 0,000 0,19215011 0,21250463 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,19215011 0,21240847 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,19215011 0,2123124 ! lipid homeostasis GO:0055088 75 40 0,000 0,19215011 0,21221642 ! mismatch repair GO:0006298 58 40 0,000 0,19215011 0,21212053 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,19215011 0,21202472 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,19215011 0,211929 ! mRNA catabolic process GO:0006402 79 41 0,000 0,19645058 0,21657435 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,19645058 0,21647666 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,19645058 0,21637906 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,19645058 0,21628155 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,19645058 0,21618412 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,19645058 0,21608679 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,19645058 0,21598954 ! RNA modification GO:0009451 64 41 0,000 0,19645058 0,21589238 ! ear morphogenesis GO:0042471 64 42 0,000 0,20072827 0,22049422 ! organic ether metabolic process GO:0018904 59 42 0,000 0,20072827 0,22039513 ! T cell differentiation GO:0030217 93 42 0,000 0,20072827 0,22029612 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,20072827 0,2201972 ! regulation of protein secretion GO:0050708 77 42 0,000 0,20072827 0,22009836 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,20072827 0,21999962 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,2049833 0,22456243 GO:0090047|positive regulation of transcription regulator activity, ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,2049833 0,22446177 ! regulation of tube size GO:0035150 76 43 0,000 0,2049833 0,22436121 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,2049833 0,22426073 ! glucose transport GO:0015758 66 43 0,000 0,2049833 0,22416035 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,2049833 0,22406005 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,2049833 0,22395984 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,2049833 0,22385973 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,2049833 0,2237597 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,2049833 0,22365976 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,2049833 0,22355992 ! segmentation GO:0035282 78 43 0,000 0,2049833 0,22346016 ! ion transmembrane transport GO:0034220 79 43 0,000 0,2049833 0,22336049 ! neuron migration GO:0001764 85 43 0,000 0,2049833 0,22326091 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,2049833 0,22316141 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,20921581 0,2276678 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,20921581 0,22756644 ! hexose transport GO:0008645 68 44 0,000 0,20921581 0,22746516 GO:0015749|monosaccharide transport, ! striated muscle contraction GO:0006941 85 44 0,000 0,20921581 0,22736398 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,20921581 0,22726288 ! double-strand break repair GO:0006302 85 44 0,000 0,20921581 0,22716188 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,2134259 0,23163015 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,2134259 0,2315273 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! B cell differentiation GO:0030183 124 45 0,000 0,2134259 0,23142453 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,2134259 0,23132186 ! female gamete generation GO:0007292 71 45 0,000 0,2134259 0,23121928 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,2134259 0,23111679 ! developmental growth GO:0048589 88 45 0,000 0,2134259 0,23101439 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,21761369 0,23544298 ! glycolysis GO:0006096 71 46 0,000 0,21761369 0,23533876 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,21761369 0,23523463 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,21761369 0,23513059 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,21761369 0,23502664 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,21761369 0,23492278 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,22177931 0,23931398 ! positive regulation of defense response GO:0031349 88 48 0,000 0,22592286 0,24367751 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,22592286 0,24356997 ! mitochondrial transport GO:0006839 94 48 0,000 0,22592286 0,24346253 ! cellular component disassembly GO:0022411 89 48 0,000 0,22592286 0,24335518 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,22592286 0,24324793 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,22592286 0,24314077 ! male sex differentiation GO:0046661 93 48 0,000 0,22592286 0,24303371 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,22592286 0,24292674 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,22592286 0,24281986 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,22592286 0,24271308 ! response to calcium ion GO:0051592 94 49 0,000 0,23004447 0,24703237 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,23004447 0,24692383 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,23004447 0,24681539 ! JNK cascade GO:0007254 106 49 0,000 0,23004447 0,24670704 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,23004447 0,24659879 ! regulation of action potential GO:0001508 102 50 0,000 0,23414425 0,25088351 ! regulation of ion transport GO:0043269 86 50 0,000 0,23414425 0,25077352 ! endocrine system development GO:0035270 109 50 0,000 0,23414425 0,25066363 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,23414425 0,25055383 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,23414425 0,25044413 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,23414425 0,25033453 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,23414425 0,25022502 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,23822231 0,25447184 ! viral infectious cycle GO:0019058 104 51 0,000 0,23822231 0,25436062 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,23822231 0,2542495 ! peptide metabolic process GO:0006518 80 51 0,000 0,23822231 0,25413847 ! response to temperature stimulus GO:0009266 84 51 0,000 0,23822231 0,25402754 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,23822231 0,25391671 ! positive regulation of binding GO:0051099 88 52 0,000 0,24227877 0,2581278 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,24227877 0,25801527 ! Notch signaling pathway GO:0007219 111 52 0,000 0,24227877 0,25790285 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,24227877 0,25779052 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,24227877 0,25767829 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,24227877 0,25756616 ! excretion GO:0007588 87 52 0,000 0,24227877 0,25745413 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,24227877 0,25734219 ! histone modification GO:0016570 104 52 0,000 0,24227877 0,25723035 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,24227877 0,25711861 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,24227877 0,25700696 ! amino acid activation GO:0043038 98 52 0,000 0,24227877 0,25689542 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,24631375 0,26106051 ! inner ear development GO:0048839 89 53 0,000 0,24631375 0,2609473 ! chromatin remodeling GO:0006338 122 53 0,000 0,24631375 0,26083419 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,24631375 0,26072118 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 0,000 0,24631375 0,26060826 ! synapse organization GO:0050808 102 53 0,000 0,24631375 0,26049545 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,25032735 0,26462558 ! regulation of translational initiation GO:0006446 87 54 0,000 0,25032735 0,26451112 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,25032735 0,26439676 ! neuromuscular process GO:0050905 107 54 0,000 0,25032735 0,2642825 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,25032735 0,26416834 ! membrane fusion GO:0006944 122 54 0,000 0,25032735 0,26405428 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,25032735 0,26394031 ! covalent chromatin modification GO:0016569 115 54 0,000 0,25032735 0,26382645 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,25032735 0,26371268 ! regulation of cell shape GO:0008360 142 54 0,000 0,25032735 0,26359901 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,25032735 0,26348544 ! RNA catabolic process GO:0006401 103 55 0,000 0,25431969 0,26757235 ! response to UV GO:0009411 120 55 0,000 0,25431969 0,26745716 ! glucose catabolic process GO:0006007 88 56 0,000 0,25829088 0,27151661 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,25829088 0,27139983 ! regulation of DNA replication GO:0006275 105 56 0,000 0,25829088 0,27128315 ! RNA elongation GO:0006354 90 56 0,000 0,25829088 0,27116657 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 0,000 0,26224103 0,27519538 ! chloride transport GO:0006821 102 57 0,000 0,26224103 0,27507721 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,26224103 0,27495916 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,26617025 0,27895922 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,26617025 0,27883959 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,26617025 0,27872007 ! aging GO:0007568 112 58 0,000 0,26617025 0,27860066 ! gastrulation GO:0007369 122 58 0,000 0,26617025 0,27848134 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,27396637 0,28651534 ! lipid modification GO:0030258 112 60 0,000 0,27396637 0,28639274 ! DNA catabolic process GO:0006308 94 60 0,000 0,27396637 0,28627025 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,27396637 0,28614786 ! kidney development GO:0001822 133 60 0,000 0,27396637 0,28602557 ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,27783347 0,28993899 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,27783347 0,28981519 ! camera-type eye development GO:0043010 126 61 0,000 0,27783347 0,28969149 ! proton transport GO:0015992 117 61 0,000 0,27783347 0,28956791 ! tRNA processing GO:0008033 102 62 0,000 0,28168009 0,29345179 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,28168009 0,29332671 ! mesoderm development GO:0007498 128 63 0,000 0,28550632 0,29718447 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,28550632 0,2970579 ! hydrogen transport GO:0006818 121 64 0,000 0,28931228 0,3008897 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,28931228 0,30076166 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,28931228 0,30063373 ! protein amino acid autophosphorylation GO:0046777 157 64 0,000 0,28931228 0,30050591 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,29309808 0,3043088 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,29309808 0,30417953 GO:0048609|reproductive process in a multicellular organism, ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,29309808 0,30405036 ! ear development GO:0043583 114 66 0,000 0,29686381 0,3078261 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,29686381 0,3076955 ! gonad development GO:0008406 115 66 0,000 0,29686381 0,30756501 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,30060959 0,31131379 ! secondary metabolic process GO:0019748 125 67 0,000 0,30060959 0,31118188 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,30433552 0,31490541 ! hexose catabolic process GO:0019320 113 68 0,000 0,30433552 0,31477209 ! adaptive immune response GO:0002250 126 68 0,000 0,30433552 0,31463888 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 0,000 0,30433552 0,31450578 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,3080417 0,31820122 ! single fertilization GO:0007338 83 69 0,000 0,3080417 0,31806673 ! cell redox homeostasis GO:0045454 114 70 0,000 0,31172825 0,32173727 ! germ cell development GO:0007281 133 70 0,000 0,31172825 0,3216014 ! activation of immune response GO:0002253 120 70 0,000 0,31172825 0,32146564 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,31172825 0,32133 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,31539525 0,32497284 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,31539525 0,32483584 ! carbohydrate transport GO:0008643 114 72 0,000 0,31904282 0,32845412 ! B cell activation GO:0042113 179 72 0,000 0,31904282 0,32831576 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,31904282 0,32817752 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,31904282 0,3280394 ! humoral immune response GO:0006959 115 73 0,000 0,32267106 0,33163038 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,32267106 0,33149092 ! acute inflammatory response GO:0002526 118 74 0,000 0,32628007 0,33505768 ! regulation of transcription factor activity GO:0051090 137 75 0,000 0,32986995 0,33860181 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 0,000 0,32986995 0,3384596 ! axon guidance GO:0007411 162 75 0,000 0,32986995 0,3383175 ! rhythmic process GO:0048511 142 75 0,000 0,32986995 0,33817553 ! learning or memory GO:0007611 161 76 0,000 0,33344081 0,34169291 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,33344081 0,34154964 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,33344081 0,34140649 ! neurotransmitter transport GO:0006836 142 77 0,000 0,33699273 0,34489872 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,33699273 0,34475429 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,33699273 0,34460998 ! regulation of catabolic process GO:0009894 173 77 0,000 0,33699273 0,34446579 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,34052583 0,34793166 ! fertilization GO:0009566 99 78 0,000 0,34052583 0,3477862 ! blood coagulation GO:0007596 151 79 0,000 0,3440402 0,35122867 GO:0050817|coagulation, ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,3440402 0,35108196 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,34753594 0,35450117 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,35101315 0,35789863 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,35791236 0,36478093 ! exocytosis GO:0006887 153 83 0,000 0,35791236 0,36462881 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,35791236 0,36447682 ! inorganic anion transport GO:0015698 156 83 0,000 0,35791236 0,36432495 ! response to metal ion GO:0010038 158 84 0,000 0,36133456 0,36765528 ! T cell activation GO:0042110 189 84 0,000 0,36133456 0,36750222 ! response to nutrient GO:0007584 135 84 0,000 0,36133456 0,36734928 ! digestion GO:0007586 130 84 0,000 0,36133456 0,36719647 ! hemostasis GO:0007599 165 85 0,000 0,36473861 0,37050163 ! negative regulation of transport GO:0051051 164 85 0,000 0,36473861 0,37034764 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,36473861 0,37019378 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,36473861 0,37004004 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,36473861 0,36988644 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,36812462 0,37316533 ! regulation of lyase activity GO:0051339 169 86 0,000 0,36812462 0,37301055 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,37149267 0,37626724 ! mitochondrion organization GO:0007005 159 87 0,000 0,37149267 0,37611131 ! nucleosome assembly GO:0006334 126 87 0,000 0,37149267 0,37595551 ! cellular respiration GO:0045333 143 88 0,000 0,37484287 0,37918887 ! sensory perception of smell GO:0007608 117 88 0,000 0,37484287 0,37903192 ! chromatin assembly GO:0031497 128 88 0,000 0,37484287 0,3788751 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,3781753 0,3820853 ! regulation of DNA binding GO:0051101 167 89 0,000 0,3781753 0,38192735 ! cellular defense response GO:0006968 123 89 0,000 0,3781753 0,38176953 ! response to inorganic substance GO:0010035 173 90 0,000 0,38149006 0,38495672 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,38149006 0,38479778 ! response to unfolded protein GO:0006986 139 90 0,000 0,38149006 0,38463897 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,38478724 0,38780332 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,38478724 0,3876434 ! bone development GO:0060348 206 92 0,000 0,38806694 0,39078629 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,38806694 0,39062528 ! vitamin metabolic process GO:0006766 153 93 0,000 0,39132925 0,39374685 ! female pregnancy GO:0007565 166 94 0,000 0,39457426 0,39684846 ! sterol metabolic process GO:0016125 166 94 0,000 0,39457426 0,39668515 ! regulation of membrane potential GO:0042391 179 94 0,000 0,39457426 0,39652197 ! nucleosome organization GO:0034728 143 95 0,000 0,39780206 0,39960133 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,39780206 0,39943709 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,39780206 0,39927298 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,39780206 0,39910901 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,39780206 0,39894517 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,39780206 0,39878146 ! sex differentiation GO:0007548 171 96 0,000 0,40101274 0,40183516 ! response to protein stimulus GO:0051789 158 96 0,000 0,40101274 0,40167041 ! regulation of DNA metabolic process GO:0051052 188 97 0,000 0,40420639 0,40470337 ! transcription initiation GO:0006352 171 97 0,000 0,40420639 0,40453757 ! forebrain development GO:0030900 210 98 0,000 0,40738311 0,40754993 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,40738311 0,40738311