pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6574-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 4,000 9,766E-11 2,386E-07 ! phospholipid dephosphorylation GO:0046839 12 5 3,000 3,727E-10 4,552E-07 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 1,115E-09 9,084E-07 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 4,000 1,29E-09 7,876E-07 ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 2,597E-09 1,269E-06 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 5,182E-09 2,11E-06 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 1,547E-08 5,4E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 1,955E-08 5,971E-06 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 4,000 2,406E-08 6,53E-06 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 3,000 2,426E-08 5,927E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of protein stability GO:0031647 77 38 4,000 9,953E-08 2,21E-05 ! endothelial cell migration GO:0043542 31 17 3,000 1,726E-07 3,513E-05 ! cardiac muscle tissue development GO:0048738 34 17 3,000 1,726E-07 3,243E-05 ! inositol metabolic process GO:0006020 33 19 3,000 2,798E-07 4,882E-05 ! myoblast cell fate commitment GO:0048625 18 6 2,000 5,122E-07 8,342E-05 ! regulation of cell-matrix adhesion GO:0001952 81 23 3,000 6,333E-07 9,67E-05 GO:0010810|regulation of cell-substrate adhesion, ! positive regulation of epithelial cell proliferation GO:0050679 73 24 3,000 7,582E-07 1,09E-04 ! positive regulation of cell migration GO:0030335 137 58 4,000 8,666E-07 1,176E-04 ! lipid modification GO:0030258 112 60 4,000 1,028E-06 1,322E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 2,000 1,428E-06 1,744E-04 ! positive regulation of insulin secretion GO:0032024 17 8 2,000 1,428E-06 1,661E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,428E-06 1,586E-04 ! fat cell differentiation GO:0045444 57 28 3,000 1,448E-06 1,538E-04 ! positive regulation of cell motion GO:0051272 157 65 4,000 1,536E-06 1,564E-04 ! negative regulation of protein kinase cascade GO:0010741 72 30 3,000 1,929E-06 1,885E-04 ! negative regulation of protein transport GO:0051224 74 33 3,000 2,86E-06 2,687E-04 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 3,572E-06 3,232E-04 ! positive regulation of peptide secretion GO:0002793 24 11 2,000 4,18E-06 3,647E-04 ! negative regulation of cell adhesion GO:0007162 94 37 3,000 4,574E-06 3,853E-04 ! maintenance of protein location in cell GO:0032507 89 37 3,000 4,574E-06 3,725E-04 ! regulation of hormone metabolic process GO:0032350 28 12 2,000 5,561E-06 4,383E-04 ! carbohydrate homeostasis GO:0033500 59 39 3,000 5,67E-06 4,329E-04 GO:0042593|glucose homeostasis, ! cellular response to hormone stimulus GO:0032870 182 85 4,000 5,82E-06 4,308E-04 ! maintenance of protein location GO:0045185 95 41 3,000 6,95E-06 4,994E-04 ! cytoplasmic sequestering of protein GO:0051220 25 13 2,000 7,214E-06 5,036E-04 ! regulation of intracellular protein transport GO:0033157 86 42 3,000 7,664E-06 5,201E-04 ! regulation of cell adhesion GO:0030155 241 92 4,000 8,582E-06 5,667E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 1,013E-05 6,514E-04 ! polyol metabolic process GO:0019751 77 45 3,000 1,013E-05 6,347E-04 ! maintenance of location in cell GO:0051651 101 45 3,000 1,013E-05 6,188E-04 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 1,107E-05 6,597E-04 ! negative regulation of cell migration GO:0030336 122 46 3,000 1,107E-05 6,44E-04 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 1,143E-05 6,492E-04 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 2,000 1,403E-05 7,792E-04 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 2,000 1,403E-05 7,619E-04 ! myoblast differentiation GO:0045445 50 17 2,000 1,7E-05 9,031E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 2,036E-05 1,058E-03 ! negative regulation of cell motion GO:0051271 142 55 3,000 2,267E-05 1,154E-03 ! positive regulation of hormone secretion GO:0046887 35 19 2,000 2,413E-05 1,203E-03 ! skeletal muscle fiber development GO:0048741 130 56 3,000 2,435E-05 1,19E-03 ! muscle fiber development GO:0048747 131 57 3,000 2,613E-05 1,252E-03 ! regulation of intracellular transport GO:0032386 108 57 3,000 2,613E-05 1,228E-03 ! maintenance of location GO:0051235 124 58 3,000 2,8E-05 1,291E-03 ! pancreas development GO:0031016 40 20 2,000 2,832E-05 1,281E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 3,297E-05 1,464E-03 ! negative regulation of intracellular transport GO:0032387 44 21 2,000 3,297E-05 1,438E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 4,137E-05 1,773E-03 ! regulation of insulin secretion GO:0050796 42 25 2,000 5,652E-05 2,381E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 6,376E-05 2,64E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 7,157E-05 2,914E-03 ! regulation of catabolic process GO:0009894 173 77 3,000 8,552E-05 3,425E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 8,759E-05 3,451E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 8,759E-05 3,396E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 8,759E-05 3,343E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 8,759E-05 3,292E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 8,759E-05 3,242E-03 ! regulation of peptide secretion GO:0002791 52 29 2,000 8,902E-05 3,246E-03 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 1,201E-04 4,313E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,201E-04 4,251E-03 ! negative regulation of transport GO:0051051 164 85 3,000 1,256E-04 4,385E-03 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 1,000 1,311E-04 4,512E-03 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! early endosome to late endosome transport GO:0045022 16 6 1,000 1,311E-04 4,449E-03 ! cytoplasmic microtubule organization GO:0031122 18 6 1,000 1,311E-04 4,388E-03 ! regulation of protein transport GO:0051223 165 87 3,000 1,375E-04 4,539E-03 GO:0070201|regulation of establishment of protein localization, ! cell fate specification GO:0001708 56 34 2,000 1,442E-04 4,698E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 1,779E-04 5,718E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,832E-04 5,813E-03 ! mRNA stabilization GO:0048255 18 7 1,000 1,832E-04 5,738E-03 GO:0043489|RNA stabilization, ! male sex determination GO:0030238 15 7 1,000 1,832E-04 5,666E-03 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 1,86E-04 5,681E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 2,016E-04 6,079E-03 ! regulation of protein localization GO:0032880 188 97 3,000 2,092E-04 6,232E-03 ! skeletal muscle tissue development GO:0007519 223 100 3,000 2,351E-04 6,921E-03 GO:0060538|skeletal muscle organ development, ! T-helper 1 type immune response GO:0042088 12 8 1,000 2,438E-04 7,091E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 2,438E-04 7,007E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,438E-04 6,926E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 2,438E-04 6,846E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 2,438E-04 6,768E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 2,438E-04 6,692E-03 ! regulation of hormone secretion GO:0046883 69 41 2,000 2,53E-04 6,869E-03 ! mesenchymal cell development GO:0014031 94 41 2,000 2,53E-04 6,793E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! hormone-mediated signaling GO:0009755 84 43 2,000 2,917E-04 7,745E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 3,129E-04 8,218E-03 ! DNA synthesis during DNA repair GO:0000731 18 9 1,000 3,129E-04 8,131E-03 ! cell proliferation in forebrain GO:0021846 18 9 1,000 3,129E-04 8,045E-03 ! induction of positive chemotaxis GO:0050930 17 9 1,000 3,129E-04 7,962E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 3,129E-04 7,879E-03 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 3,129E-04 7,799E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 3,129E-04 7,72E-03 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 1,000 3,129E-04 7,643E-03 ! receptor clustering GO:0043113 20 9 1,000 3,129E-04 7,567E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 3,565E-04 8,538E-03 ! response to insulin stimulus GO:0032868 98 47 2,000 3,799E-04 9,012E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 3,903E-04 9,169E-03 ! lung alveolus development GO:0048286 26 10 1,000 3,903E-04 9,081E-03 ! motor axon guidance GO:0008045 22 10 1,000 3,903E-04 8,996E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 3,903E-04 8,911E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 3,903E-04 8,829E-03 ! induction of an organ GO:0001759 17 10 1,000 3,903E-04 8,748E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 3,903E-04 8,668E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 3,903E-04 8,59E-03 ! positive regulation of cell cycle GO:0045787 96 48 2,000 4,044E-04 8,821E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 4,761E-04 0,01029336 ! blood vessel remodeling GO:0001974 30 11 1,000 4,761E-04 0,01020307 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 4,761E-04 0,01011434 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 4,761E-04 0,01002715 ! regulation of embryonic development GO:0045995 35 11 1,000 4,761E-04 9,941E-03 ! nucleus localization GO:0051647 22 11 1,000 4,761E-04 9,857E-03 ! synapse organization GO:0050808 102 53 2,000 5,418E-04 0,01112334 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 5,702E-04 0,01160885 ! virus-host interaction GO:0019048 30 12 1,000 5,702E-04 0,01151291 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 5,702E-04 0,01141854 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 5,702E-04 0,01132571 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 5,702E-04 0,01123437 ! regulation of leukocyte migration GO:0002685 29 12 1,000 5,702E-04 0,0111445 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 5,702E-04 0,01105605 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 5,702E-04 0,01096899 ! developmental induction GO:0031128 22 12 1,000 5,702E-04 0,0108833 GO:0045168|cell-cell signaling involved in cell fate specification, ! localization within membrane GO:0051668 26 12 1,000 5,702E-04 0,01079893 ! response to UV GO:0009411 120 55 2,000 6,042E-04 0,01135387 ! regulation of protein catabolic process GO:0042176 126 56 2,000 6,37E-04 0,01187926 ! regulation of DNA replication GO:0006275 105 56 2,000 6,37E-04 0,01178926 ! nucleotide-excision repair GO:0006289 91 57 2,000 6,709E-04 0,01232399 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 6,726E-04 0,01226225 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 6,726E-04 0,01217142 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 6,726E-04 0,01208192 ! regulation of mRNA stability GO:0043488 32 13 1,000 6,726E-04 0,01199374 ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 7,832E-04 0,01386426 ! regulation of RNA stability GO:0043487 33 14 1,000 7,832E-04 0,01376452 ! positive regulation of secretion GO:0051047 110 61 2,000 8,182E-04 0,01427673 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 9,019E-04 0,0156264 ! regulation of mRNA processing GO:0050684 26 15 1,000 9,019E-04 0,01551635 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 9,019E-04 0,01540785 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 9,41E-04 0,01596465 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 1,029E-03 0,01733231 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 1,029E-03 0,01721359 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,029E-03 0,0170965 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 1,029E-03 0,01698098 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 1,029E-03 0,01687273 ! signal complex assembly GO:0007172 47 17 1,000 1,164E-03 0,01895158 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,164E-03 0,01882607 ! lung development GO:0030324 165 69 2,000 1,171E-03 0,01881531 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 1,272E-03 0,02030308 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 1,307E-03 0,02072638 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 1,307E-03 0,02059266 ! respiratory tube development GO:0030323 171 72 2,000 1,324E-03 0,02073363 ! respiratory system development GO:0060541 175 74 2,000 1,433E-03 0,0222959 ! cerebral cortex development GO:0021987 40 19 1,000 1,457E-03 0,02253444 ! neuromuscular junction development GO:0007528 43 19 1,000 1,457E-03 0,02239271 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 1,457E-03 0,02225276 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 1,489E-03 0,02259909 ! axon guidance GO:0007411 162 75 2,000 1,489E-03 0,02245959 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 1,616E-03 0,02422305 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 1,616E-03 0,02407535 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 1,616E-03 0,02392944 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 1,616E-03 0,02378529 GO:0010675|regulation of cellular carbohydrate metabolic process, ! cellular response to unfolded protein GO:0034620 35 20 1,000 1,616E-03 0,02364286 GO:0030968|endoplasmic reticulum unfolded protein response, ! negative regulation of T cell activation GO:0050868 41 20 1,000 1,616E-03 0,02350213 ! lipid phosphorylation GO:0046834 43 21 1,000 1,783E-03 0,02577216 ! muscle cell differentiation GO:0042692 178 81 2,000 1,858E-03 0,02669547 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 1,858E-03 0,02653935 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 1,957E-03 0,02780081 ! positive regulation of locomotion GO:0040017 44 22 1,000 1,957E-03 0,02764011 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of intracellular transport GO:0032388 42 22 1,000 1,957E-03 0,02748126 ! protein stabilization GO:0050821 41 22 1,000 1,957E-03 0,02732422 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 1,992E-03 0,02764887 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of DNA replication GO:0045740 44 23 1,000 2,14E-03 0,02953092 ! regulation of chemotaxis GO:0050920 45 23 1,000 2,14E-03 0,02936501 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 2,33E-03 0,03179375 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 2,33E-03 0,03161711 ! sex determination GO:0007530 48 24 1,000 2,33E-03 0,03144243 ! pallium development GO:0021543 56 24 1,000 2,33E-03 0,03126967 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 2,33E-03 0,0310988 ! negative regulation of catabolic process GO:0009895 52 24 1,000 2,33E-03 0,03092978 ! vasculogenesis GO:0001570 49 25 1,000 2,527E-03 0,0333727 ! receptor metabolic process GO:0043112 53 25 1,000 2,527E-03 0,03319328 ! regulation of behavior GO:0050795 48 25 1,000 2,527E-03 0,03301577 ! interaction with host GO:0051701 66 25 1,000 2,527E-03 0,03284016 ! protein tetramerization GO:0051262 57 25 1,000 2,527E-03 0,0326664 ! myelination GO:0042552 50 26 1,000 2,732E-03 0,03513403 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 2,732E-03 0,03495008 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 2,732E-03 0,03476805 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 2,945E-03 0,03728246 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 2,945E-03 0,03709028 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 3,101E-03 0,03885618 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 3,166E-03 0,0394591 ! base-excision repair GO:0006284 41 28 1,000 3,166E-03 0,0392588 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 3,166E-03 0,03906052 ! interphase of mitotic cell cycle GO:0051329 224 98 2,000 3,193E-03 0,03919317 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 3,394E-03 0,04145381 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 3,394E-03 0,04124757 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 3,629E-03 0,04388978 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 3,629E-03 0,04367357 GO:0048871|multicellular organismal homeostasis, ! ensheathment of neurons GO:0007272 64 31 1,000 3,872E-03 0,04636664 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 3,872E-03 0,04614046 ! spindle organization GO:0007051 50 32 1,000 4,122E-03 0,04888266 ! mesoderm formation GO:0001707 73 32 1,000 4,122E-03 0,04864651 ! peripheral nervous system development GO:0007422 68 32 1,000 4,122E-03 0,04841263 ! formation of primary germ layer GO:0001704 76 34 1,000 4,644E-03 0,05428409 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 4,644E-03 0,05402559 ! mesoderm morphogenesis GO:0048332 80 35 1,000 4,916E-03 0,05691786 ! telencephalon development GO:0021537 81 35 1,000 4,916E-03 0,05664938 ! calcium-mediated signaling GO:0019722 67 35 1,000 4,916E-03 0,05638342 ! negative regulation of DNA binding GO:0043392 67 36 1,000 5,195E-03 0,05930606 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 5,481E-03 0,06228258 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 5,481E-03 0,06199423 ! odontogenesis GO:0042476 74 37 1,000 5,481E-03 0,06170854 ! tissue remodeling GO:0048771 78 37 1,000 5,481E-03 0,06142548 ! regulation of microtubule-based process GO:0032886 86 37 1,000 5,481E-03 0,06114499 ! negative regulation of cell activation GO:0050866 69 37 1,000 5,481E-03 0,06086706 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 5,775E-03 0,06383407 ! negative regulation of binding GO:0051100 71 39 1,000 6,075E-03 0,06685187 ! mammary gland development GO:0030879 93 40 1,000 6,382E-03 0,06991931 ! mismatch repair GO:0006298 58 40 1,000 6,382E-03 0,06960717 ! regulation of action potential in neuron GO:0019228 80 40 1,000 6,382E-03 0,0692978 ! regulation of T cell differentiation GO:0045580 78 42 1,000 7,018E-03 0,07586139 ! regulation of T cell proliferation GO:0042129 80 43 1,000 7,346E-03 0,07905832 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 1,000 7,681E-03 0,08230038 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 7,681E-03 0,08194098 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 8,371E-03 0,08891566 ! cell growth GO:0016049 90 46 1,000 8,371E-03 0,08853075 ! positive regulation of protein transport GO:0051222 80 46 1,000 8,371E-03 0,08814915 ! endosome transport GO:0016197 127 48 1,000 9,088E-03 0,09528838 ! vascular process in circulatory system GO:0003018 85 48 1,000 9,088E-03 0,09488117 ! response to calcium ion GO:0051592 94 49 1,000 9,457E-03 0,09830758 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 9,457E-03 0,09789103 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 9,457E-03 0,09747798 ! regulation of action potential GO:0001508 102 50 1,000 9,832E-03 0,10091778 ! induction of apoptosis by extracellular signals GO:0008624 99 50 1,000 9,832E-03 0,10049553 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,01021307 0,10396058 ! positive regulation of growth GO:0045927 96 53 1,000 0,01099559 0,1114615 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 0,01099559 0,11100091 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of angiogenesis GO:0045765 125 54 1,000 0,01139648 0,11457446 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,01139648 0,11410489 GO:0010863|positive regulation of phospholipase C activity, ! regulation of cell shape GO:0008360 142 54 1,000 0,01139648 0,11363916 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,01180373 0,11722163 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,01263719 0,12499046 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,01263719 0,12448647 ! heart morphogenesis GO:0003007 105 57 1,000 0,01263719 0,12398652 ! gastrulation GO:0007369 122 58 1,000 0,0130633 0,12765456 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,0130633 0,12714597 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,0130633 0,12664142 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01482325 0,14313521 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01482325 0,14257169 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01482325 0,14201258 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01482325 0,14145785 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01482325 0,14090743 ! neuron fate determination GO:0048664 7 5 0,000 0,01482325 0,14036127 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01482325 0,13981934 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01482325 0,13928157 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01482325 0,13874793 ! polyol transport GO:0015791 12 5 0,000 0,01482325 0,13821835 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01482325 0,13769281 ! response to superoxide GO:0000303 10 5 0,000 0,01482325 0,13717125 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01482325 0,13665362 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01482325 0,13613988 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01482325 0,13563 ! female meiosis GO:0007143 10 5 0,000 0,01482325 0,13512391 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01482325 0,13462159 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01482325 0,134123 ! hypothalamus development GO:0021854 9 5 0,000 0,01482325 0,13362808 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01482325 0,1331368 ! cobalt ion transport GO:0006824 11 5 0,000 0,01482325 0,13264912 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01482325 0,132165 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01482325 0,1316844 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01482325 0,13120728 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01482325 0,13073361 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01482325 0,13026334 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01482325 0,12979645 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01482325 0,12933289 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01482325 0,12887263 ! transposition GO:0032196 9 5 0,000 0,01482325 0,12841563 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01482325 0,12796187 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01482325 0,1275113 ! negative chemotaxis GO:0050919 16 5 0,000 0,01482325 0,12706389 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01482325 0,12661961 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01482325 0,12617843 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01482325 0,12574031 ! behavioral response to pain GO:0048266 10 5 0,000 0,01482325 0,12530522 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01482325 0,12487313 ! Notch receptor processing GO:0007220 11 5 0,000 0,01482325 0,12444402 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01482325 0,12401784 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01482325 0,12359457 ! micturition GO:0060073 9 5 0,000 0,01482325 0,12317418 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01482325 0,12275664 ! copulation GO:0007620 9 5 0,000 0,01482325 0,12234192 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01482325 0,12193 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01482325 0,12152084 ! bioluminescence GO:0008218 9 5 0,000 0,01482325 0,12111441 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01482325 0,1207107 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01482325 0,12030966 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01482325 0,11991129 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01482325 0,11951554 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01482325 0,1191224 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01482325 0,11873183 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01482325 0,11834382 ! grooming behavior GO:0007625 6 5 0,000 0,01482325 0,11795834 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01482325 0,11757535 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01482325 0,11719485 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01482325 0,1168168 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01482325 0,11644119 ! response to protozoan GO:0001562 13 5 0,000 0,01482325 0,11606798 ! lymph vessel development GO:0001945 10 5 0,000 0,01482325 0,11569715 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01482325 0,11532869 ! endochondral ossification GO:0001958 17 5 0,000 0,01482325 0,11496257 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01482325 0,11459876 ! single strand break repair GO:0000012 8 5 0,000 0,01482325 0,11423725 ! parathyroid gland development GO:0060017 14 5 0,000 0,01482325 0,11387802 ! anagen GO:0042640 7 5 0,000 0,01482325 0,11352103 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01482325 0,11316628 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01482325 0,11281373 ! cytokine secretion GO:0050663 15 5 0,000 0,01482325 0,11246338 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01482325 0,1121152 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01482325 0,11176916 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01482325 0,11142526 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01482325 0,11108346 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01482325 0,11074376 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01482325 0,11040612 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01482325 0,11007054 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01482325 0,109737 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01482325 0,10940546 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01482325 0,10907593 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01482325 0,10874838 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01482325 0,10842278 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01482325 0,10809913 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01482325 0,10777741 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01482325 0,10745759 ! microvillus organization GO:0032528 8 5 0,000 0,01482325 0,10713967 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01482325 0,10682363 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01482325 0,10650944 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01482325 0,10619709 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01482325 0,10588658 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01482325 0,10557787 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01482325 0,10527096 ! polyol catabolic process GO:0046174 9 5 0,000 0,01482325 0,10496582 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01482325 0,10466245 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01482325 0,10436083 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01482325 0,10406095 ! muscle cell migration GO:0014812 8 5 0,000 0,01482325 0,10376278 ! mitochondrial fission GO:0000266 8 5 0,000 0,01482325 0,10346631 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01482325 0,10317154 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01482325 0,10287843 ! mRNA transcription GO:0009299 10 5 0,000 0,01482325 0,10258699 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01482325 0,1022972 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01482325 0,10200904 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01482325 0,1017225 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01482325 0,10143756 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01482325 0,10115421 ! monocyte activation GO:0042117 10 5 0,000 0,01482325 0,10087245 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01482325 0,10059225 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01482325 0,1003136 ! response to food GO:0032094 6 5 0,000 0,01482325 0,10003649 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01482325 0,09976091 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01482325 0,09948684 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01482325 0,09921427 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01482325 0,09894319 ! forebrain neuron development GO:0021884 13 5 0,000 0,01482325 0,09867359 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01482325 0,09840546 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01482325 0,09813878 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01482325 0,09787354 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01482325 0,09760973 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01482325 0,09734734 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01482325 0,09708635 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01482325 0,09682676 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01482325 0,09656856 ! lipid glycosylation GO:0030259 7 5 0,000 0,01482325 0,09631173 ! nucleobase transport GO:0015851 6 5 0,000 0,01482325 0,09605626 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01482325 0,09580214 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01482325 0,09554936 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01482325 0,09529792 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01482325 0,09504779 ! basic amino acid transport GO:0015802 12 5 0,000 0,01482325 0,09479898 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01482325 0,09455146 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01482325 0,09430523 ! actin nucleation GO:0045010 11 5 0,000 0,01482325 0,09406028 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01482325 0,0938166 ! depurination GO:0045007 5 5 0,000 0,01482325 0,09357418 ! depyrimidination GO:0045008 10 5 0,000 0,01482325 0,09333301 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01482325 0,09309308 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01482325 0,09285438 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01482325 0,0926169 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01482325 0,09238063 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01482325 0,09214557 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01482325 0,0919117 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01482325 0,09167901 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01482325 0,0914475 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01482325 0,09121715 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01482325 0,09098796 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01482325 0,09075992 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01482325 0,09053302 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01482325 0,09030725 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01482325 0,09008261 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01482325 0,08985908 ! response to arsenic GO:0046685 11 5 0,000 0,01482325 0,08963666 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01482325 0,08941533 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01482325 0,0891951 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01482325 0,08897594 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01482325 0,08875786 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01482325 0,08854085 ! response to mercury ion GO:0046689 8 5 0,000 0,01482325 0,0883249 ! response to cadmium ion GO:0046686 7 5 0,000 0,01482325 0,08811 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01482325 0,08789614 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01482325 0,08768331 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01482325 0,08747152 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01482325 0,08726074 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01482325 0,08705098 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01482325 0,08684223 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01482325 0,08663447 ! decidualization GO:0046697 11 5 0,000 0,01482325 0,08642771 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01482325 0,08622193 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01482325 0,08601712 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01482325 0,08581329 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01482325 0,08561042 ! embryonic cleavage GO:0040016 6 5 0,000 0,01482325 0,08540851 ! peroxisome fission GO:0016559 5 5 0,000 0,01482325 0,08520755 ! histone demethylation GO:0016577 13 5 0,000 0,01482325 0,08500753 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01482325 0,08480845 ! mitotic recombination GO:0006312 9 5 0,000 0,01482325 0,0846103 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01482325 0,08441307 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01482325 0,08421676 ! metaphase plate congression GO:0051310 7 5 0,000 0,01482325 0,08402137 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01482325 0,08382687 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01482325 0,08363328 ! enteric nervous system development GO:0048484 8 5 0,000 0,01482325 0,08344057 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01482325 0,08324876 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01482325 0,08305782 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01482325 0,08286775 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01482325 0,08267856 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01482325 0,08249023 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01482325 0,08230275 ! B cell homeostasis GO:0001782 13 5 0,000 0,01482325 0,08211612 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01482325 0,08193034 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01482325 0,08174539 ! metaphase GO:0051323 11 5 0,000 0,01482325 0,08156128 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01482325 0,081378 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01482325 0,08119554 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01482325 0,08101389 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01482325 0,08083306 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01482325 0,08065303 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01482325 0,0804738 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01482325 0,08029536 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01482325 0,08011772 ! response to redox state GO:0051775 6 5 0,000 0,01482325 0,07994086 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01482325 0,07976478 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01482325 0,07958947 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01482325 0,07941493 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01482325 0,07924116 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01482325 0,07906814 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01482325 0,07889588 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01482325 0,07872437 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01482325 0,0785536 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01482325 0,07838357 ! striatum development GO:0021756 14 5 0,000 0,01482325 0,07821427 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01482325 0,07804571 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01482325 0,07787787 ! glial cell migration GO:0008347 10 5 0,000 0,01482325 0,07771075 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01482325 0,07754434 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01482325 0,07737865 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01482325 0,07721367 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01482325 0,07704938 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01482325 0,07688579 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01482325 0,0767229 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01482325 0,0765607 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01482325 0,07639917 ! neuroprotection GO:0043526 8 5 0,000 0,01482325 0,07623833 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01482325 0,07607817 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01482325 0,07591868 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01482325 0,07575985 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01482325 0,07560169 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01482325 0,07544419 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01482325 0,07528734 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01482325 0,07513114 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01482325 0,07497559 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01482325 0,07482068 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01482325 0,07466641 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01482325 0,07451278 ! spindle assembly GO:0051225 6 5 0,000 0,01482325 0,07435977 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01482325 0,0742074 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01482325 0,07405564 ! protein palmitoylation GO:0018345 12 5 0,000 0,01482325 0,07390451 ! drug metabolic process GO:0017144 7 5 0,000 0,01482325 0,07375399 ! stem cell division GO:0017145 11 5 0,000 0,01482325 0,07360408 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01482325 0,07345478 ! organ regeneration GO:0031100 7 5 0,000 0,01482325 0,07330609 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01482325 0,073158 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01482325 0,0730105 ! viral reproductive process GO:0022415 132 62 1,000 0,0148294 0,07289383 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,0148294 0,07274745 ! mesoderm development GO:0007498 128 63 1,000 0,01528614 0,07483777 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,01717277 0,08390617 ! activation of MAPK activity GO:0000187 124 67 1,000 0,01717277 0,0837387 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,01765916 0,08593888 ! viral reproduction GO:0016032 142 68 1,000 0,01765916 0,08576803 ! regulation of lipase activity GO:0060191 137 68 1,000 0,01765916 0,08559785 ! adaptive immune response GO:0002250 126 68 1,000 0,01765916 0,08542835 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01776168 0,08575451 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01776168 0,08558537 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01776168 0,0854169 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01776168 0,08524909 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01776168 0,08508193 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01776168 0,08491543 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01776168 0,08474958 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01776168 0,08458438 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01776168 0,08441981 ! response to oxygen radical GO:0000305 11 6 0,000 0,01776168 0,08425589 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01776168 0,08409261 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01776168 0,08392995 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01776168 0,08376792 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01776168 0,08360652 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01776168 0,08344574 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01776168 0,08328557 ! forebrain regionalization GO:0021871 9 6 0,000 0,01776168 0,08312602 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01776168 0,08296708 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01776168 0,08280875 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01776168 0,08265102 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01776168 0,08249389 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01776168 0,08233735 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01776168 0,08218141 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01776168 0,08202606 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01776168 0,08187129 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01776168 0,08171711 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01776168 0,0815635 ! malate metabolic process GO:0006108 13 6 0,000 0,01776168 0,08141048 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01776168 0,08125802 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01776168 0,08110614 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01776168 0,08095482 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01776168 0,08080407 ! protein refolding GO:0042026 15 6 0,000 0,01776168 0,08065387 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01776168 0,08050424 ! opsonization GO:0008228 8 6 0,000 0,01776168 0,08035516 ! mating behavior GO:0007617 7 6 0,000 0,01776168 0,08020663 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01776168 0,08005864 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01776168 0,07991121 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01776168 0,07976431 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01776168 0,07961795 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01776168 0,07947213 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01776168 0,07932685 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01776168 0,07918209 ! toxin metabolic process GO:0009404 11 6 0,000 0,01776168 0,07903786 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01776168 0,07889415 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01776168 0,07875097 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01776168 0,07860831 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01776168 0,07846616 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01776168 0,07832452 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01776168 0,0781834 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01776168 0,07804278 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01776168 0,07790267 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01776168 0,07776305 ! thymic T cell selection GO:0045061 16 6 0,000 0,01776168 0,07762394 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01776168 0,07748533 ! protein lipoylation GO:0009249 10 6 0,000 0,01776168 0,07734721 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01776168 0,07720958 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01776168 0,07707244 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01776168 0,07693579 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01776168 0,07679962 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01776168 0,07666393 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01776168 0,07652872 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01776168 0,07639399 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01776168 0,07625973 ! hyperosmotic response GO:0006972 10 6 0,000 0,01776168 0,07612594 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01776168 0,07599262 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01776168 0,07585976 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01776168 0,07572737 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01776168 0,07559544 ! urea metabolic process GO:0019627 7 6 0,000 0,01776168 0,07546397 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01776168 0,07533296 ! neutrophil activation GO:0042119 7 6 0,000 0,01776168 0,0752024 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01776168 0,07507229 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01776168 0,07494263 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01776168 0,07481342 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01776168 0,07468466 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01776168 0,07455633 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01776168 0,07442845 ! neuron apoptosis GO:0051402 15 6 0,000 0,01776168 0,074301 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01776168 0,07417399 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01776168 0,07404741 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01776168 0,07392127 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01776168 0,07379555 ! carnitine transport GO:0015879 10 6 0,000 0,01776168 0,07367026 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01776168 0,0735454 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01776168 0,07342096 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01776168 0,07329693 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01776168 0,07317333 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01776168 0,07305014 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01776168 0,07292737 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01776168 0,07280501 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01776168 0,07268306 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01776168 0,07256151 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01776168 0,07244037 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01776168 0,07231964 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01776168 0,07219931 ! response to UV-C GO:0010225 14 6 0,000 0,01776168 0,07207938 ! astrocyte development GO:0014002 16 6 0,000 0,01776168 0,07195984 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01776168 0,0718407 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01776168 0,07172196 ! interaction with symbiont GO:0051702 14 6 0,000 0,01776168 0,0716036 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01776168 0,07148564 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01776168 0,07136807 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01776168 0,07125088 ! response to copper ion GO:0046688 10 6 0,000 0,01776168 0,07113407 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01776168 0,07101765 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01776168 0,07090161 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01776168 0,07078595 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01776168 0,07067066 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01776168 0,07055575 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01776168 0,07044121 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01776168 0,07032704 ! hair follicle maturation GO:0048820 8 6 0,000 0,01776168 0,07021324 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01776168 0,07009981 ! Schwann cell development GO:0014044 15 6 0,000 0,01776168 0,06998675 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01776168 0,06987405 ! response to pheromone GO:0019236 6 6 0,000 0,01776168 0,06976171 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01776168 0,06964973 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01776168 0,06953812 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01776168 0,06942686 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01776168 0,06931595 ! subpallium development GO:0021544 15 6 0,000 0,01776168 0,0692054 ! neural tube patterning GO:0021532 8 6 0,000 0,01776168 0,0690952 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01776168 0,06898535 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01776168 0,06887585 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01776168 0,0687667 ! G2 phase GO:0051319 16 6 0,000 0,01776168 0,06865789 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01776168 0,06854942 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01776168 0,0684413 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01776168 0,06833352 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01776168 0,06822608 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01776168 0,06811897 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01776168 0,0680122 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01776168 0,06790577 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01776168 0,06779966 ! receptor internalization GO:0031623 11 6 0,000 0,01776168 0,06769389 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01776168 0,06758845 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01776168 0,06748334 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01776168 0,06737855 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01776168 0,06727408 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01776168 0,06716995 ! protein deubiquitination GO:0016579 16 6 0,000 0,01776168 0,06706613 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01776168 0,06696263 ! protein destabilization GO:0031648 9 6 0,000 0,01776168 0,06685945 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01776168 0,06675659 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01776168 0,06665405 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01776168 0,06655182 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01776168 0,0664499 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01776168 0,06634829 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01776168 0,066247 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01776168 0,06614601 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01776168 0,06604533 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01776168 0,06594496 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01776168 0,06584489 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01776168 0,06574513 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01776168 0,06564566 ! neural plate development GO:0001840 9 6 0,000 0,01776168 0,0655465 ! catecholamine transport GO:0051937 9 6 0,000 0,01776168 0,06544764 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01776168 0,06534907 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01776168 0,0652508 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01776168 0,06515283 ! maternal placenta development GO:0001893 12 6 0,000 0,01776168 0,06505515 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01776168 0,06495776 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01776168 0,06486066 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01776168 0,06476386 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01776168 0,06466734 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01776168 0,06457111 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01776168 0,06447516 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01776168 0,0643795 GO:0055081|anion homeostasis, ! negative regulation of cell size GO:0045792 144 69 1,000 0,01815135 0,06569444 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01815135 0,06559726 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,01915302 0,06911496 ! actin filament organization GO:0007015 167 72 1,000 0,01966242 0,07084852 ! tRNA transcription GO:0009304 17 7 0,000 0,02069142 0,07444647 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02069142 0,07433699 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02069142 0,07422783 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02069142 0,07411899 ! regulation of helicase activity GO:0051095 16 7 0,000 0,02069142 0,07401047 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02069142 0,07390227 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02069142 0,07379438 ! sleep GO:0030431 16 7 0,000 0,02069142 0,07368681 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02069142 0,07357955 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02069142 0,0734726 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02069142 0,07336597 ! prostate gland development GO:0030850 14 7 0,000 0,02069142 0,07325964 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02069142 0,07315362 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02069142 0,07304791 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02069142 0,0729425 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02069142 0,07283739 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02069142 0,07273259 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02069142 0,07262809 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02069142 0,07252389 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02069142 0,07241999 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02069142 0,07231638 ! glycolipid transport GO:0046836 11 7 0,000 0,02069142 0,07221307 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02069142 0,07211006 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,02069142 0,07200734 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,02069142 0,07190491 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02069142 0,07180277 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02069142 0,07170092 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02069142 0,07159936 ! pericardium development GO:0060039 16 7 0,000 0,02069142 0,07149809 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02069142 0,07139711 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02069142 0,0712964 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,02069142 0,07119599 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02069142 0,07109585 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,02069142 0,070996 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02069142 0,07089642 ! lipoprotein transport GO:0042953 14 7 0,000 0,02069142 0,07079713 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02069142 0,07069811 ! rhythmic behavior GO:0007622 17 7 0,000 0,02069142 0,07059937 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02069142 0,07050091 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02069142 0,07040272 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02069142 0,0703048 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02069142 0,07020715 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02069142 0,07010978 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02069142 0,07001267 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02069142 0,06991584 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02069142 0,06981927 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02069142 0,06972297 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02069142 0,06962693 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02069142 0,06953116 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02069142 0,06943565 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02069142 0,0693404 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02069142 0,06924541 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02069142 0,06915068 ! spinal cord patterning GO:0021511 14 7 0,000 0,02069142 0,06905622 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02069142 0,06896201 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02069142 0,06886805 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02069142 0,06877435 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02069142 0,06868091 ! adrenal gland development GO:0030325 17 7 0,000 0,02069142 0,06858772 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02069142 0,06849478 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02069142 0,0684021 ! ovulation GO:0030728 10 7 0,000 0,02069142 0,06830966 ! adenohypophysis development GO:0021984 11 7 0,000 0,02069142 0,06821748 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02069142 0,06812554 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02069142 0,06803385 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02069142 0,06794241 ! microtubule nucleation GO:0007020 21 7 0,000 0,02069142 0,06785121 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02069142 0,06776026 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02069142 0,06766955 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02069142 0,06757908 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02069142 0,06748885 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02069142 0,06739887 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02069142 0,06730912 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02069142 0,06721962 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02069142 0,06713035 ! galactose metabolic process GO:0006012 13 7 0,000 0,02069142 0,06704131 ! vesicle fusion GO:0006906 20 7 0,000 0,02069142 0,06695252 ! response to dietary excess GO:0002021 8 7 0,000 0,02069142 0,06686396 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02069142 0,06677563 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02069142 0,06668753 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02069142 0,06659967 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02069142 0,06651204 ! organ growth GO:0035265 15 7 0,000 0,02069142 0,06642464 ! nucleoside transport GO:0015858 11 7 0,000 0,02069142 0,06633747 ! nucleoside salvage GO:0043174 11 7 0,000 0,02069142 0,06625052 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02069142 0,06616381 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02069142 0,06607732 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02069142 0,06599106 ! parturition GO:0007567 16 7 0,000 0,02069142 0,06590502 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02069142 0,06581921 ! rRNA modification GO:0000154 14 7 0,000 0,02069142 0,06573362 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02069142 0,06564825 ! spindle checkpoint GO:0031577 16 7 0,000 0,02069142 0,0655631 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02069142 0,06547817 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02069142 0,06539347 ! monocyte differentiation GO:0030224 16 7 0,000 0,02069142 0,06530898 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02069142 0,06522471 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02069142 0,06514066 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02069142 0,06505682 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02069142 0,0649732 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,02069142 0,0648898 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02069142 0,0648066 ! fibrinolysis GO:0042730 11 7 0,000 0,02069142 0,06472362 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02069142 0,06464086 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02069142 0,0645583 ! eating behavior GO:0042755 8 7 0,000 0,02069142 0,06447596 ! B cell lineage commitment GO:0002326 21 7 0,000 0,02069142 0,06439382 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02069142 0,0643119 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02069142 0,06423018 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02069142 0,06414867 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02069142 0,06406736 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02069142 0,06398627 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02069142 0,06390537 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02069142 0,06382468 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02069142 0,0637442 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02069142 0,06366392 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02069142 0,06358384 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02069142 0,06350396 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02069142 0,06342428 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02069142 0,0633448 ! histone ubiquitination GO:0016574 9 7 0,000 0,02069142 0,06326552 ! regulation of meiosis GO:0040020 12 7 0,000 0,02069142 0,06318644 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02069142 0,06310755 ! T cell lineage commitment GO:0002360 16 7 0,000 0,02069142 0,06302887 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02069142 0,06295037 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02069142 0,06287208 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02069142 0,06279398 ! transcription termination GO:0006353 14 7 0,000 0,02069142 0,06271607 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02069142 0,06263835 ! anaphase GO:0051322 18 7 0,000 0,02069142 0,06256083 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02069142 0,0624835 ! axonal fasciculation GO:0007413 19 7 0,000 0,02069142 0,06240636 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02069142 0,06232941 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02069142 0,06225265 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02069142 0,06217608 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02069142 0,06209969 ! diuresis GO:0030146 12 7 0,000 0,02069142 0,0620235 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02069142 0,06194749 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02069142 0,06187167 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02069142 0,06179603 ! antibiotic transport GO:0042891 9 7 0,000 0,02069142 0,06172057 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02069142 0,06164531 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02069142 0,06157022 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02069142 0,06149532 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02069142 0,0614206 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02069142 0,06134606 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02069142 0,0612717 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02069142 0,06119752 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02069142 0,06112352 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02069142 0,0610497 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02069142 0,06097606 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02069142 0,06090259 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02069142 0,0608293 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02069142 0,06075619 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02069142 0,06068325 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02069142 0,06061049 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02069142 0,0605379 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02069142 0,06046549 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02069142 0,06039325 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02069142 0,06032118 ! muscle adaptation GO:0043500 13 7 0,000 0,02069142 0,06024929 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02069142 0,06017756 ! retina homeostasis GO:0001895 12 7 0,000 0,02069142 0,06010601 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02069142 0,06003462 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02069142 0,05996341 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02069142 0,05989236 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02069142 0,05982148 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,02069817 0,05977024 ! organelle localization GO:0051640 155 74 1,000 0,02069817 0,05969968 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,02122444 0,0611454 GO:0090046|regulation of transcription regulator activity, ! protein oligomerization GO:0051259 149 79 1,000 0,02338462 0,06728932 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02361251 0,06786514 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02361251 0,06778539 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02361251 0,06770583 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02361251 0,06762646 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02361251 0,06754727 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02361251 0,06746827 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02361251 0,06738945 ! male meiosis GO:0007140 9 8 0,000 0,02361251 0,06731082 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02361251 0,06723236 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02361251 0,0671541 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02361251 0,06707601 ! meiotic prophase I GO:0007128 14 8 0,000 0,02361251 0,06699811 ! response to zinc ion GO:0010043 12 8 0,000 0,02361251 0,06692038 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,02361251 0,06684284 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02361251 0,06676547 ! oligopeptide transport GO:0006857 16 8 0,000 0,02361251 0,06668829 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02361251 0,06661128 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02361251 0,06653445 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02361251 0,0664578 ! signal peptide processing GO:0006465 12 8 0,000 0,02361251 0,06638132 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02361251 0,06630502 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02361251 0,0662289 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02361251 0,06615295 ! succinate metabolic process GO:0006105 17 8 0,000 0,02361251 0,06607717 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02361251 0,06600157 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02361251 0,06592614 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02361251 0,06585088 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02361251 0,06577579 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02361251 0,06570088 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02361251 0,06562613 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02361251 0,06555156 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02361251 0,06547715 ! reflex GO:0060004 17 8 0,000 0,02361251 0,06540291 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02361251 0,06532884 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02361251 0,06525494 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02361251 0,06518121 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02361251 0,06510764 ! pigment granule organization GO:0048753 17 8 0,000 0,02361251 0,06503424 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02361251 0,064961 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02361251 0,06488793 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02361251 0,06481502 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02361251 0,06474228 ! histidine catabolic process GO:0006548 10 8 0,000 0,02361251 0,0646697 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02361251 0,06459728 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02361251 0,06452502 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02361251 0,06445293 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,02361251 0,06438099 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02361251 0,06430922 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02361251 0,0642376 ! melanin metabolic process GO:0006582 17 8 0,000 0,02361251 0,06416615 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02361251 0,06409485 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02361251 0,06402372 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02361251 0,06395274 ! macrophage activation GO:0042116 13 8 0,000 0,02361251 0,06388191 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02361251 0,06381125 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02361251 0,06374074 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02361251 0,06367039 ! purine salvage GO:0043101 12 8 0,000 0,02361251 0,06360019 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02361251 0,06353014 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02361251 0,06346025 ! osteoblast development GO:0002076 17 8 0,000 0,02361251 0,06339052 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02361251 0,06332093 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02361251 0,0632515 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02361251 0,06318222 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02361251 0,06311309 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02361251 0,06304412 ! response to UV-B GO:0010224 17 8 0,000 0,02361251 0,06297529 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02361251 0,06290662 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02361251 0,06283809 ! intermediate filament organization GO:0045109 12 8 0,000 0,02361251 0,06276972 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02361251 0,06270149 ! cellular extravasation GO:0045123 13 8 0,000 0,02361251 0,06263341 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02361251 0,06256548 ! response to antibiotic GO:0046677 11 8 0,000 0,02361251 0,06249769 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02361251 0,06243005 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02361251 0,06236256 ! DNA topological change GO:0006265 12 8 0,000 0,02361251 0,06229521 ! response to tropane GO:0014073 15 8 0,000 0,02361251 0,06222801 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,02361251 0,06216096 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02361251 0,06209405 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02361251 0,06202728 ! mast cell activation GO:0045576 14 8 0,000 0,02361251 0,06196065 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02361251 0,06189417 ! gas homeostasis GO:0033483 14 8 0,000 0,02361251 0,06182783 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02361251 0,06176164 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02361251 0,06169558 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02361251 0,06162967 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02361251 0,06156389 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02361251 0,06149826 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,02361251 0,06143277 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02361251 0,06136741 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02361251 0,0613022 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02361251 0,06123712 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02361251 0,06117218 ! response to tumor cell GO:0002347 16 8 0,000 0,02361251 0,06110738 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02361251 0,06104272 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02361251 0,06097819 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02361251 0,0609138 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02361251 0,06084955 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02361251 0,06078543 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02361251 0,06072144 ! hormone catabolic process GO:0042447 17 8 0,000 0,02361251 0,06065759 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02361251 0,06059387 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02361251 0,06053029 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02361251 0,06046684 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02361251 0,06040353 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02361251 0,06034034 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02361251 0,06027729 ! adult feeding behavior GO:0008343 10 8 0,000 0,02361251 0,06021437 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02361251 0,06015158 ! ATP catabolic process GO:0006200 11 8 0,000 0,02361251 0,06008893 ! blastocyst growth GO:0001832 19 8 0,000 0,02361251 0,0600264 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02361251 0,059964 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02361251 0,05990173 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02361251 0,05983959 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02361251 0,05977758 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02361251 0,0597157 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02361251 0,05965395 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02361251 0,05959232 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02361251 0,05953082 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02361251 0,05946945 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02361251 0,05940821 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02361251 0,05934709 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02361251 0,05928609 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02361251 0,05922522 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02361251 0,05916448 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02361251 0,05910386 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02361251 0,05904337 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02361251 0,05898299 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02361251 0,05892275 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02361251 0,05886262 ! response to hypoxia GO:0001666 178 81 1,000 0,02449726 0,06100593 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,02563122 0,06376483 ! response to oxygen levels GO:0070482 183 83 1,000 0,02563122 0,06369996 ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,02563122 0,06363523 ! response to metal ion GO:0010038 158 84 1,000 0,0262061 0,06499644 ! axon extension GO:0048675 16 9 0,000 0,02652497 0,06572059 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02652497 0,065654 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02652497 0,06558755 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02652497 0,06552123 GO:0006740|NADPH regeneration, ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02652497 0,06545505 ! reproductive behavior GO:0019098 22 9 0,000 0,02652497 0,065389 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02652497 0,06532309 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02652497 0,0652573 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02652497 0,06519165 ! UTP metabolic process GO:0046051 10 9 0,000 0,02652497 0,06512613 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02652497 0,06506074 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02652497 0,06499549 ! artery development GO:0060840 25 9 0,000 0,02652497 0,06493036 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02652497 0,06486537 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02652497 0,0648005 ! equilibrioception GO:0050957 20 9 0,000 0,02652497 0,06473577 ! chemosensory behavior GO:0007635 21 9 0,000 0,02652497 0,06467116 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02652497 0,06460668 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02652497 0,06454233 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02652497 0,06447811 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02652497 0,06441402 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02652497 0,06435005 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02652497 0,06428621 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02652497 0,0642225 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02652497 0,06415891 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02652497 0,06409545 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02652497 0,06403212 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02652497 0,06396891 ! protein targeting to ER GO:0045047 25 9 0,000 0,02652497 0,06390582 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02652497 0,06384286 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02652497 0,06378002 ! T cell selection GO:0045058 27 9 0,000 0,02652497 0,06371731 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02652497 0,06365472 ! glycine catabolic process GO:0006546 15 9 0,000 0,02652497 0,06359225 ! endosome organization GO:0007032 20 9 0,000 0,02652497 0,0635299 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02652497 0,06346768 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02652497 0,06340558 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02652497 0,0633436 ! mannose metabolic process GO:0006013 13 9 0,000 0,02652497 0,06328174 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02652497 0,06322 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02652497 0,06315838 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02652497 0,06309689 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02652497 0,06303551 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02652497 0,06297425 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02652497 0,06291311 ! retinol metabolic process GO:0042572 20 9 0,000 0,02652497 0,06285209 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02652497 0,06279118 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02652497 0,0627304 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02652497 0,06266973 ! macrophage differentiation GO:0030225 15 9 0,000 0,02652497 0,06260918 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02652497 0,06254875 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02652497 0,06248843 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02652497 0,06242823 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02652497 0,06236814 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02652497 0,06230817 ! response to amine stimulus GO:0014075 13 9 0,000 0,02652497 0,06224832 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02652497 0,06218858 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02652497 0,06212896 ! erythrocyte development GO:0048821 17 9 0,000 0,02652497 0,06206945 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02652497 0,06201005 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02652497 0,06195077 ! renal water homeostasis GO:0003091 15 9 0,000 0,02652497 0,0618916 ! postreplication repair GO:0006301 25 9 0,000 0,02652497 0,06183254 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02652497 0,0617736 ! icosanoid secretion GO:0032309 15 9 0,000 0,02652497 0,06171476 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02652497 0,06165604 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02652497 0,06159743 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02652497 0,06153894 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02652497 0,06148055 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02652497 0,06142228 ! sterol catabolic process GO:0016127 14 9 0,000 0,02652497 0,06136411 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02652497 0,06130606 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02652497 0,06124811 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02652497 0,06119028 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02652497 0,06113255 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,02652497 0,06107493 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02652497 0,06101742 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02652497 0,06096002 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02652497 0,06090273 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02652497 0,06084554 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02652497 0,06078846 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02652497 0,06073149 ! purine base metabolic process GO:0006144 25 9 0,000 0,02652497 0,06067463 ! pigment granule transport GO:0051904 17 9 0,000 0,02652497 0,06061787 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02652497 0,06056122 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02652497 0,06050467 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02652497 0,06044823 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02652497 0,06039189 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02652497 0,06033566 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02652497 0,06027954 ! mitochondrion localization GO:0051646 18 9 0,000 0,02652497 0,06022351 ! negative regulation of growth GO:0045926 168 85 1,000 0,02678619 0,06076014 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,02678619 0,06070378 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,02737148 0,06197267 ! regulation of lyase activity GO:0051339 169 86 1,000 0,02737148 0,06191529 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,02915807 0,06589563 ! regulation of DNA binding GO:0051101 167 89 1,000 0,02915807 0,06583473 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02942882 0,06638468 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,02942882 0,06632344 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02942882 0,06626231 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02942882 0,0662013 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02942882 0,0661404 ! associative learning GO:0008306 21 10 0,000 0,02942882 0,0660796 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,02942882 0,06601893 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02942882 0,06595836 ! phosphate transport GO:0006817 24 10 0,000 0,02942882 0,0658979 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02942882 0,06583755 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02942882 0,06577732 ! CTP metabolic process GO:0046036 11 10 0,000 0,02942882 0,06571719 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02942882 0,06565718 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02942882 0,06559727 ! GTP metabolic process GO:0046039 11 10 0,000 0,02942882 0,06553747 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02942882 0,06547779 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02942882 0,06541821 ! social behavior GO:0035176 29 10 0,000 0,02942882 0,06535874 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02942882 0,06529937 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02942882 0,06524012 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02942882 0,06518097 ! androgen metabolic process GO:0008209 17 10 0,000 0,02942882 0,06512193 ! phospholipid efflux GO:0033700 19 10 0,000 0,02942882 0,065063 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02942882 0,06500417 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02942882 0,06494545 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02942882 0,06488683 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02942882 0,06482832 ! pathogenesis GO:0009405 17 10 0,000 0,02942882 0,06476992 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02942882 0,06471162 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02942882 0,06465343 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02942882 0,06459534 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02942882 0,06453735 ! endoderm development GO:0007492 18 10 0,000 0,02942882 0,06447947 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02942882 0,06442169 ! arginine catabolic process GO:0006527 17 10 0,000 0,02942882 0,06436402 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02942882 0,06430645 ! proline metabolic process GO:0006560 13 10 0,000 0,02942882 0,06424898 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02942882 0,06419162 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02942882 0,06413435 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02942882 0,06407719 ! V(D)J recombination GO:0033151 34 10 0,000 0,02942882 0,06402013 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02942882 0,06396318 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02942882 0,06390632 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02942882 0,06384956 ! B cell proliferation GO:0042100 19 10 0,000 0,02942882 0,06379291 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02942882 0,06373636 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02942882 0,0636799 ! multicellular organism growth GO:0035264 19 10 0,000 0,02942882 0,06362355 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02942882 0,06356729 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02942882 0,06351114 ! ruffle organization GO:0031529 17 10 0,000 0,02942882 0,06345508 ! epithelial cell development GO:0002064 21 10 0,000 0,02942882 0,06339913 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02942882 0,06334327 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02942882 0,06328751 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02942882 0,06323185 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02942882 0,06317628 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02942882 0,06312082 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02942882 0,06306545 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,02942882 0,06301018 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02942882 0,062955 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02942882 0,06289992 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02942882 0,06284494 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02942882 0,06279005 ! segment specification GO:0007379 15 10 0,000 0,02942882 0,06273526 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02942882 0,06268057 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02942882 0,06262597 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02942882 0,06257146 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02942882 0,06251705 ! response to dsRNA GO:0043331 23 10 0,000 0,02942882 0,06246274 ! DNA ligation GO:0006266 18 10 0,000 0,02942882 0,06240852 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02942882 0,06235439 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02942882 0,06230036 ! melanosome localization GO:0032400 16 10 0,000 0,02942882 0,06224642 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02942882 0,06219257 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02942882 0,06213882 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02942882 0,06208516 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02942882 0,06203159 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02942882 0,06197811 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02942882 0,06192473 ! protein sumoylation GO:0016925 17 10 0,000 0,02942882 0,06187144 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02942882 0,06181824 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02942882 0,06176513 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02942882 0,06171211 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02942882 0,06165919 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02942882 0,06160635 ! salivary gland development GO:0007431 28 10 0,000 0,02942882 0,0615536 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02942882 0,06150095 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02942882 0,06144838 ! midbrain development GO:0030901 14 10 0,000 0,02942882 0,06139591 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02942882 0,06134352 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02942882 0,06129123 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02942882 0,06123902 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02942882 0,0611869 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02942882 0,06113487 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02942882 0,06108293 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02942882 0,06103108 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02942882 0,06097931 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02942882 0,06092764 ! detection of calcium ion GO:0005513 24 10 0,000 0,02942882 0,06087605 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02942882 0,06082454 ! blastocyst formation GO:0001825 18 10 0,000 0,02942882 0,06077313 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02942882 0,0607218 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02942882 0,06067056 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02942882 0,0606194 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02942882 0,06056833 ! response to nicotine GO:0035094 20 10 0,000 0,02942882 0,06051735 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02942882 0,06046645 ! response to inorganic substance GO:0010035 173 90 1,000 0,02976374 0,06110321 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,02976374 0,0610519 ! response to unfolded protein GO:0006986 139 90 1,000 0,02976374 0,06100068 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,03037441 0,06220008 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 1,000 0,03037441 0,06214798 ! gland development GO:0048732 220 91 1,000 0,03037441 0,06209598 ! bone development GO:0060348 206 92 1,000 0,03099006 0,06330161 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,03161065 0,06451531 ! regulation of membrane potential GO:0042391 179 94 1,000 0,03223614 0,06573698 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03232409 0,06586135 ! respiratory burst GO:0045730 17 11 0,000 0,03232409 0,06580646 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03232409 0,06575167 ! neuron fate specification GO:0048665 18 11 0,000 0,03232409 0,06569697 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03232409 0,06564236 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03232409 0,06558784 ! thyroid gland development GO:0030878 26 11 0,000 0,03232409 0,06553341 ! synapsis GO:0007129 14 11 0,000 0,03232409 0,06547907 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03232409 0,06542482 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03232409 0,06537066 ! response to pain GO:0048265 27 11 0,000 0,03232409 0,06531659 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,03232409 0,06526261 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03232409 0,06520872 ! bone resorption GO:0045453 16 11 0,000 0,03232409 0,06515491 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03232409 0,0651012 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,03232409 0,06504757 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03232409 0,06499404 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03232409 0,06494059 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03232409 0,06488723 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03232409 0,06483395 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03232409 0,06478077 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03232409 0,06472767 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03232409 0,06467466 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,03232409 0,06462173 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03232409 0,06456889 ! UV protection GO:0009650 20 11 0,000 0,03232409 0,06451614 ! adult heart development GO:0007512 16 11 0,000 0,03232409 0,06446347 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03232409 0,06441089 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03232409 0,0643584 ! macroautophagy GO:0016236 19 11 0,000 0,03232409 0,06430599 ! temperature homeostasis GO:0001659 18 11 0,000 0,03232409 0,06425367 ! behavioral fear response GO:0001662 27 11 0,000 0,03232409 0,06420143 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03232409 0,06414927 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03232409 0,0640972 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03232409 0,06404522 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03232409 0,06399332 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03232409 0,0639415 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03232409 0,06388977 ! regulation of organ growth GO:0046620 14 11 0,000 0,03232409 0,06383812 ! pigment granule localization GO:0051875 20 11 0,000 0,03232409 0,06378656 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03232409 0,06373507 ! vasoconstriction GO:0042310 20 11 0,000 0,03232409 0,06368367 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03232409 0,06363236 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03232409 0,06358112 ! embryonic axis specification GO:0000578 19 11 0,000 0,03232409 0,06352997 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03232409 0,0634789 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03232409 0,06342792 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03232409 0,06337701 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03232409 0,06332619 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03232409 0,06327545 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03232409 0,06322478 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03232409 0,0631742 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03232409 0,06312371 ! prophase GO:0051324 17 11 0,000 0,03232409 0,06307329 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03232409 0,06302295 ! nucleosome positioning GO:0016584 15 11 0,000 0,03232409 0,06297269 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03232409 0,06292251 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03232409 0,06287242 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03232409 0,0628224 ! apical protein localization GO:0045176 18 11 0,000 0,03232409 0,06277246 ! acid secretion GO:0046717 20 11 0,000 0,03232409 0,0627226 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03232409 0,06267282 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03232409 0,06262312 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03232409 0,0625735 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03232409 0,06252396 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03232409 0,06247449 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03232409 0,0624251 ! cholesterol efflux GO:0033344 21 11 0,000 0,03232409 0,06237579 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03232409 0,06232656 ! oocyte development GO:0048599 20 11 0,000 0,03232409 0,06227741 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03232409 0,06222833 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03232409 0,06217934 ! embryonic gut development GO:0048566 19 11 0,000 0,03232409 0,06213041 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03232409 0,06208157 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03232409 0,0620328 ! activation of innate immune response GO:0002218 16 11 0,000 0,03232409 0,06198411 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03232409 0,06193549 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03232409 0,06188696 ! lysogeny GO:0030069 22 11 0,000 0,03232409 0,06183849 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03232409 0,06179011 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03232409 0,0617418 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03232409 0,06169356 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,03286651 0,06267985 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,03286651 0,06263095 ! response to protein stimulus GO:0051789 158 96 1,000 0,03350171 0,06379164 ! regulation of T cell activation GO:0050863 175 96 1,000 0,03350171 0,06374196 ! forebrain development GO:0030900 210 98 1,000 0,03478649 0,06613494 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,03478649 0,06608351 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,03521081 0,06683761 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,03521081 0,06678571 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,03521081 0,0667339 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,03521081 0,06668217 ! mating GO:0007618 17 12 0,000 0,03521081 0,06663052 ! protein complex disassembly GO:0043241 28 12 0,000 0,03521081 0,06657895 GO:0043624|cellular protein complex disassembly, ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,03521081 0,06652746 ! hippocampus development GO:0021766 29 12 0,000 0,03521081 0,06647604 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,03521081 0,06642471 ! T cell proliferation GO:0042098 32 12 0,000 0,03521081 0,06637346 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03521081 0,06632228 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,03521081 0,06627119 ! ventral spinal cord development GO:0021517 25 12 0,000 0,03521081 0,06622017 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,03521081 0,06616923 ! drug transport GO:0015893 16 12 0,000 0,03521081 0,06611837 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,03521081 0,06606759 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,03521081 0,06601688 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,03521081 0,06596626 ! polyamine metabolic process GO:0006595 18 12 0,000 0,03521081 0,06591571 ! focal adhesion formation GO:0048041 37 12 0,000 0,03521081 0,06586524 ! mitotic spindle organization GO:0007052 23 12 0,000 0,03521081 0,06581484 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,03521081 0,06576453 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,03521081 0,06571429 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,03521081 0,06566412 ! lipid digestion GO:0044241 21 12 0,000 0,03521081 0,06561404 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,03521081 0,06556403 ! entry into host cell GO:0030260 34 12 0,000 0,03521081 0,06551409 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03521081 0,06546423 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,03521081 0,06541445 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,03521081 0,06536474 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03521081 0,06531511 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,03521081 0,06526555 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,03521081 0,06521607 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,03521081 0,06516667 ! snRNA metabolic process GO:0016073 30 12 0,000 0,03521081 0,06511734 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,03521081 0,06506808 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,03521081 0,0650189 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03521081 0,06496979 ! cranial nerve development GO:0021545 23 12 0,000 0,03521081 0,06492076 ! fucose catabolic process GO:0019317 25 12 0,000 0,03521081 0,0648718 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,03521081 0,06482291 ! histone acetylation GO:0016573 27 12 0,000 0,03521081 0,0647741 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,03521081 0,06472536 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03521081 0,06467669 ! zymogen activation GO:0031638 18 12 0,000 0,03521081 0,0646281 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,03521081 0,06457958 ! T cell homeostasis GO:0043029 28 12 0,000 0,03521081 0,06453113 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,03521081 0,06448276 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,03521081 0,06443446 ! oocyte differentiation GO:0009994 21 12 0,000 0,03521081 0,06438623 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,03521081 0,06433807 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,03521081 0,06428999 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,03521081 0,06424197 ! defense response to fungus GO:0050832 15 12 0,000 0,03521081 0,06419403 ! embryonic placenta development GO:0001892 21 12 0,000 0,03521081 0,06414616 ! lamellipodium assembly GO:0030032 24 12 0,000 0,03521081 0,06409836 ! response to cold GO:0009409 17 12 0,000 0,03521081 0,06405063 ! establishment of cell polarity GO:0030010 21 12 0,000 0,03521081 0,06400298 ! regulation of synapse organization GO:0050807 18 12 0,000 0,03521081 0,06395539 ! mRNA transport GO:0051028 185 100 1,000 0,03609021 0,065504 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,03808899 0,06908048 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03808899 0,06902923 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,03808899 0,06897806 ! regulation of chemokine production GO:0032642 18 13 0,000 0,03808899 0,06892697 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,03808899 0,06887595 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,03808899 0,068825 ! peroxisomal transport GO:0043574 28 13 0,000 0,03808899 0,06877414 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,03808899 0,06872334 ! cartilage condensation GO:0001502 22 13 0,000 0,03808899 0,06867262 ! organelle fusion GO:0048284 36 13 0,000 0,03808899 0,06862198 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,03808899 0,06857141 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,03808899 0,06852092 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,03808899 0,0684705 ! endocrine pancreas development GO:0031018 25 13 0,000 0,03808899 0,06842015 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,03808899 0,06836988 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,03808899 0,06831968 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,03808899 0,06826956 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,03808899 0,06821951 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,03808899 0,06816953 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03808899 0,06811962 ! methionine metabolic process GO:0006555 31 13 0,000 0,03808899 0,06806979 ! plasma membrane organization GO:0007009 27 13 0,000 0,03808899 0,06802003 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,03808899 0,06797035 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,03808899 0,06792073 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,03808899 0,06787119 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,03808899 0,06782172 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,03808899 0,06777233 ! cytokine metabolic process GO:0042107 24 13 0,000 0,03808899 0,067723 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,03808899 0,06767375 ! exocrine system development GO:0035272 34 13 0,000 0,03808899 0,06762457 ! asymmetric protein localization GO:0008105 24 13 0,000 0,03808899 0,06757546 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,03808899 0,06752642 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,03808899 0,06747745 ! L-glutamate transport GO:0015813 30 13 0,000 0,03808899 0,06742855 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,03808899 0,06737973 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,03808899 0,06733097 ! protein homotetramerization GO:0051289 24 13 0,000 0,03808899 0,06728229 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,03808899 0,06723367 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,03808899 0,06718513 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,03808899 0,06713666 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,03808899 0,06708825 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,03808899 0,06703992 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03808899 0,06699165 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,03808899 0,06694346 ! histone methylation GO:0016571 29 13 0,000 0,03808899 0,06689533 ! chromatin silencing GO:0006342 29 13 0,000 0,03808899 0,06684727 ! gland morphogenesis GO:0022612 31 13 0,000 0,03808899 0,06679929 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,03808899 0,06675137 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,03808899 0,06670352 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03808899 0,06665573 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,03808899 0,06660802 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,03808899 0,06656038 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,03808899 0,0665128 ! spleen development GO:0048536 24 13 0,000 0,03808899 0,06646529 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,03808899 0,06641785 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,03808899 0,06637047 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,03808899 0,06632317 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,03808899 0,06627593 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03808899 0,06622876 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,03808899 0,06618165 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,03808899 0,06613462 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,03808899 0,06608765 ! insulin secretion GO:0030073 24 13 0,000 0,03808899 0,06604074 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,03808899 0,0659939 ! acrosome reaction GO:0007340 19 13 0,000 0,03808899 0,06594713 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,03808899 0,06590043 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,03808899 0,06585379 ! rRNA transcription GO:0009303 28 14 0,000 0,04095867 0,07076523 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04095867 0,07071522 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,04095867 0,07066528 ! water transport GO:0006833 21 14 0,000 0,04095867 0,07061541 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04095867 0,07056561 ! non-recombinational repair GO:0000726 29 14 0,000 0,04095867 0,07051588 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04095867 0,07046622 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04095867 0,07041663 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04095867 0,07036711 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04095867 0,07031766 ! lipid localization GO:0010876 32 14 0,000 0,04095867 0,07026828 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04095867 0,07021897 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,04095867 0,07016973 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04095867 0,07012055 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04095867 0,07007145 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04095867 0,07002242 ! arginine metabolic process GO:0006525 21 14 0,000 0,04095867 0,06997345 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04095867 0,06992455 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,04095867 0,06987572 ! regulation of heart rate GO:0002027 25 14 0,000 0,04095867 0,06982696 ! fear response GO:0042596 34 14 0,000 0,04095867 0,06977826 ! organic alcohol transport GO:0015850 29 14 0,000 0,04095867 0,06972964 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04095867 0,06968108 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,04095867 0,06963259 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,04095867 0,06958417 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04095867 0,06953581 ! bone mineralization GO:0030282 18 14 0,000 0,04095867 0,06948752 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04095867 0,0694393 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04095867 0,06939115 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04095867 0,06934306 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04095867 0,06929504 ! regulation of cellular pH GO:0030641 27 14 0,000 0,04095867 0,06924708 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,04095867 0,06919919 ! ribosome assembly GO:0042255 18 14 0,000 0,04095867 0,06915137 ! cerebellum development GO:0021549 23 14 0,000 0,04095867 0,06910361 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04095867 0,06905592 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,04095867 0,0690083 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04095867 0,06896074 ! response to gamma radiation GO:0010332 30 14 0,000 0,04095867 0,06891324 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04095867 0,06886582 ! NADP metabolic process GO:0006739 24 14 0,000 0,04095867 0,06881845 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,04095867 0,06877116 ! oxygen transport GO:0015671 22 14 0,000 0,04095867 0,06872392 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04095867 0,06867675 ! male genitalia development GO:0030539 26 14 0,000 0,04095867 0,06862965 ! regulation of axon extension GO:0030516 43 14 0,000 0,04095867 0,06858261 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,04095867 0,06853564 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04095867 0,06848873 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04095867 0,06844188 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,04381987 0,07317289 ! lactation GO:0007595 30 15 0,000 0,04381987 0,07312291 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,04381987 0,073073 ! reproductive cellular process GO:0048610 22 15 0,000 0,04381987 0,07302315 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,04381987 0,07297337 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,04381987 0,07292366 ! superoxide anion generation GO:0042554 22 15 0,000 0,04381987 0,07287402 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,04381987 0,07282445 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,04381987 0,07277494 ! copper ion transport GO:0006825 22 15 0,000 0,04381987 0,0727255 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,04381987 0,07267613 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,04381987 0,07262682 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,04381987 0,07257759 ! sulfate transport GO:0008272 27 15 0,000 0,04381987 0,07252841 ! response to cAMP GO:0051591 25 15 0,000 0,04381987 0,07247931 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,04381987 0,07243027 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,04381987 0,0723813 ! response to hexose stimulus GO:0009746 25 15 0,000 0,04381987 0,07233239 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,04381987 0,07228355 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,04381987 0,07223478 ! vesicle coating GO:0006901 38 15 0,000 0,04381987 0,07218607 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,04381987 0,07213743 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,04381987 0,07208885 ! regulation of exocytosis GO:0017157 26 15 0,000 0,04381987 0,07204034 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,04381987 0,07199189 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,04381987 0,07194351 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,04381987 0,07189519 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,04381987 0,07184694 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,04381987 0,07179875 ! regulation of vasodilation GO:0042312 27 15 0,000 0,04381987 0,07175063 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,04381987 0,07170257 ! histone deacetylation GO:0016575 24 15 0,000 0,04381987 0,07165458 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,04381987 0,07160665 ! water homeostasis GO:0030104 28 15 0,000 0,04381987 0,07155878 ! cofactor transport GO:0051181 30 15 0,000 0,04381987 0,07151098 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,04381987 0,07146324 ! muscle maintenance GO:0046716 26 15 0,000 0,04381987 0,07141557 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,04381987 0,07136796 ! intestinal absorption GO:0050892 31 15 0,000 0,04381987 0,07132041 ! dopamine metabolic process GO:0042417 35 15 0,000 0,04381987 0,07127293 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,04381987 0,07122551 ! heme biosynthetic process GO:0006783 33 15 0,000 0,04381987 0,07117815 ! cell killing GO:0001906 32 15 0,000 0,04381987 0,07113086 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,04381987 0,07108363 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,04381987 0,07103646 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,04381987 0,07098935 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,04381987 0,07094231 ! actin filament polymerization GO:0030041 27 15 0,000 0,04381987 0,07089532 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,04381987 0,0708484 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,04667261 0,07541084 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04667261 0,075361 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04667261 0,07531122 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04667261 0,07526151 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,04667261 0,07521187 ! bone remodeling GO:0046849 28 16 0,000 0,04667261 0,07516229 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04667261 0,07511277 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04667261 0,07506332 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04667261 0,07501394 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04667261 0,07496462 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04667261 0,07491537 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,04667261 0,07486618 ! startle response GO:0001964 28 16 0,000 0,04667261 0,07481705 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04667261 0,07476799 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04667261 0,074719 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04667261 0,07467007 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04667261 0,0746212 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04667261 0,07457239 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04667261 0,07452365 ! pituitary gland development GO:0021983 30 16 0,000 0,04667261 0,07447498 ! response to osmotic stress GO:0006970 27 16 0,000 0,04667261 0,07442636 ! lysosomal transport GO:0007041 31 16 0,000 0,04667261 0,07437781 ! fructose metabolic process GO:0006000 25 16 0,000 0,04667261 0,07432933 ! L-amino acid transport GO:0015807 33 16 0,000 0,04667261 0,07428091 ! stem cell development GO:0048864 46 16 0,000 0,04667261 0,07423255 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04667261 0,07418425 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04667261 0,07413601 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04667261 0,07408784 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04667261 0,07403973 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04667261 0,07399169 ! axon cargo transport GO:0008088 46 16 0,000 0,04667261 0,0739437 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04667261 0,07389578 ! DNA replication initiation GO:0006270 28 16 0,000 0,04667261 0,07384792 ! neuron recognition GO:0008038 40 16 0,000 0,04667261 0,07380012 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04667261 0,07375239 ! tissue regeneration GO:0042246 27 16 0,000 0,04667261 0,07370471 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04667261 0,0736571 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04667261 0,07360955 ! biomineral formation GO:0031214 22 16 0,000 0,04667261 0,07356206 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04667261 0,07351463 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04667261 0,07346726 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,04667261 0,07341995 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04667261 0,07337271 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04667261 0,07332552 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04667261 0,0732784 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04667261 0,07323134 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,04667261 0,07318433 ! peptide hormone processing GO:0016486 27 16 0,000 0,04667261 0,07313739 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,04951692 0,07754477 ! metencephalon development GO:0022037 32 17 0,000 0,04951692 0,07749509 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,04951692 0,07744548 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,04951692 0,07739593 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,04951692 0,07734645 ! filopodium assembly GO:0046847 42 17 0,000 0,04951692 0,07729702 ! gene silencing by RNA GO:0031047 38 17 0,000 0,04951692 0,07724766 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,04951692 0,07719837 ! glial cell development GO:0021782 28 17 0,000 0,04951692 0,07714913 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,04951692 0,07709996 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,04951692 0,07705086 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,04951692 0,07700181 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,04951692 0,07695283 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,04951692 0,07690391 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,04951692 0,07685505 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,04951692 0,07680625 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,04951692 0,07675751 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,04951692 0,07670884 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,04951692 0,07666023 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,04951692 0,07661168 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,04951692 0,07656319 ! membrane budding GO:0006900 42 17 0,000 0,04951692 0,07651476 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,04951692 0,0764664 ! regulation of protein binding GO:0043393 33 17 0,000 0,04951692 0,07641809 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,04951692 0,07636985 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,04951692 0,07632167 ! genitalia development GO:0048806 32 17 0,000 0,04951692 0,07627355 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,04951692 0,07622548 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,04951692 0,07617748 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,04951692 0,07612954 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,04951692 0,07608166 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,04951692 0,07603384 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,04951692 0,07598608 ! steroid catabolic process GO:0006706 34 17 0,000 0,04951692 0,07593838 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,04951692 0,07589074 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,04951692 0,07584316 ! gas transport GO:0015669 26 17 0,000 0,04951692 0,07579564 ! organic cation transport GO:0015695 32 17 0,000 0,04951692 0,07574818 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,04951692 0,07570078 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,04951692 0,07565344 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,05235283 0,07993622 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,05235283 0,0798863 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,05235283 0,07983643 ! limbic system development GO:0021761 40 18 0,000 0,05235283 0,07978662 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,05235283 0,07973688 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,05235283 0,0796872 ! adult walking behavior GO:0007628 36 18 0,000 0,05235283 0,07963758 ! patterning of blood vessels GO:0001569 43 18 0,000 0,05235283 0,07958803 ! heart looping GO:0001947 34 18 0,000 0,05235283 0,07953853 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,05235283 0,0794891 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,05235283 0,07943973 ! centrosome cycle GO:0007098 26 18 0,000 0,05235283 0,07939042 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,05235283 0,07934117 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,05235283 0,07929198 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,05235283 0,07924285 ! glycine metabolic process GO:0006544 30 18 0,000 0,05235283 0,07919378 ! glutamine metabolic process GO:0006541 29 18 0,000 0,05235283 0,07914478 ! response to retinoic acid GO:0032526 31 18 0,000 0,05235283 0,07909583 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,05235283 0,07904695 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,05235283 0,07899812 ! DNA integration GO:0015074 32 18 0,000 0,05235283 0,07894936 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,05235283 0,07890065 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,05235283 0,07885201 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,05235283 0,07880343 ! neural crest cell migration GO:0001755 41 18 0,000 0,05235283 0,0787549 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,05235283 0,07870644 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,05235283 0,07865803 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,05235283 0,07860969 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,05235283 0,0785614 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,05235283 0,07851317 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,05235283 0,07846501 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,05235283 0,0784169 ! detection of bacterium GO:0016045 22 18 0,000 0,05235283 0,07836885 ! nerve development GO:0021675 34 18 0,000 0,05235283 0,07832086 ! defense response to virus GO:0051607 43 18 0,000 0,05235283 0,07827293 ! microspike assembly GO:0030035 46 18 0,000 0,05235283 0,07822505 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,05235283 0,07817724 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,05235283 0,07812948 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,05518035 0,0822989 ! positive regulation of translation GO:0045727 31 19 0,000 0,05518035 0,08224869 ! negative regulation of defense response GO:0031348 27 19 0,000 0,05518035 0,08219854 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,05518035 0,08214845 ! neuron maturation GO:0042551 46 19 0,000 0,05518035 0,08209842 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,05518035 0,08204845 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,05518035 0,08199854 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,05518035 0,08194869 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,05518035 0,08189891 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,05518035 0,08184918 ! memory GO:0007613 34 19 0,000 0,05518035 0,08179951 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,05518035 0,08174991 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,05518035 0,08170036 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,05518035 0,08165088 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,05518035 0,08160145 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,05518035 0,08155209 ! pigmentation during development GO:0048066 42 19 0,000 0,05518035 0,08150278 ! response to vitamin A GO:0033189 32 19 0,000 0,05518035 0,08145353 ! heme metabolic process GO:0042168 40 19 0,000 0,05518035 0,08140435 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,05518035 0,08135522 ! response to fungus GO:0009620 26 19 0,000 0,05518035 0,08130615 ! peptide cross-linking GO:0018149 39 19 0,000 0,05518035 0,08125714 ! protein export from nucleus GO:0006611 40 19 0,000 0,05518035 0,08120819 ! heart process GO:0003015 32 19 0,000 0,05518035 0,0811593 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,05518035 0,08111047 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,05518035 0,0810617 ! visual learning GO:0008542 38 19 0,000 0,05518035 0,08101298 ! cellular pigmentation GO:0033059 37 19 0,000 0,05518035 0,08096432 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,05518035 0,08091573 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,05518035 0,08086719 ! vitamin transport GO:0051180 31 19 0,000 0,05518035 0,0808187 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,05518035 0,08077028 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,05518035 0,08072192 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,05518035 0,08067361 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,05518035 0,08062536 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,05518035 0,08057717 ! cilium assembly GO:0042384 38 19 0,000 0,05518035 0,08052903 ! peptide hormone secretion GO:0030072 32 19 0,000 0,05518035 0,08048096 ! protein secretion GO:0009306 45 20 0,000 0,05799952 0,08454226 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,05799952 0,08449184 ! positive regulation of ossification GO:0045778 50 20 0,000 0,05799952 0,08444149 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,05799952 0,0843912 ! skin development GO:0043588 42 20 0,000 0,05799952 0,08434097 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,05799952 0,08429079 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,05799952 0,08424068 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,05799952 0,08419063 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,05799952 0,08414063 ! response to vitamin GO:0033273 36 20 0,000 0,05799952 0,0840907 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,05799952 0,08404082 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,05799952 0,083991 ! bile acid metabolic process GO:0008206 34 20 0,000 0,05799952 0,08394125 ! response to alkaloid GO:0043279 38 20 0,000 0,05799952 0,08389155 ! retinoid metabolic process GO:0001523 34 20 0,000 0,05799952 0,08384191 GO:0016101|diterpenoid metabolic process, ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,05799952 0,08379233 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,05799952 0,0837428 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,05799952 0,08369334 GO:0032392|DNA geometric change, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,05799952 0,08364393 ! actin filament bundle formation GO:0051017 47 20 0,000 0,05799952 0,08359459 ! body fluid secretion GO:0007589 33 20 0,000 0,05799952 0,0835453 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,05799952 0,08349607 ! peptide secretion GO:0002790 38 20 0,000 0,05799952 0,08344689 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,05799952 0,08339778 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,05799952 0,08334872 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,05799952 0,08329972 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,05799952 0,08325078 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,05799952 0,08320189 ! cell-cell junction organization GO:0045216 43 20 0,000 0,05799952 0,08315307 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,05799952 0,08310429 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,05799952 0,08305558 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,05799952 0,08300693 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,05799952 0,08295833 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,05799952 0,08290979 ! regulation of glucose import GO:0046324 30 20 0,000 0,05799952 0,0828613 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,05799952 0,08281287 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,05799952 0,0827645 ! negative regulation of translation GO:0017148 32 20 0,000 0,05799952 0,08271618 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,05799952 0,08266792 ! regulation of cell killing GO:0031341 46 21 0,000 0,06081035 0,08662373 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,06081035 0,08657325 ! hormone secretion GO:0046879 39 21 0,000 0,06081035 0,08652282 ! cAMP metabolic process GO:0046058 41 21 0,000 0,06081035 0,08647246 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,06081035 0,08642216 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,06081035 0,08637191 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,06081035 0,08632173 ! ovarian follicle development GO:0001541 39 21 0,000 0,06081035 0,0862716 ! smooth muscle contraction GO:0006939 48 21 0,000 0,06081035 0,08622153 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,06081035 0,08617151 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,06081035 0,08612156 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,06081035 0,08607166 ! plasma membrane fusion GO:0045026 33 21 0,000 0,06081035 0,08602182 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,06081035 0,08597204 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,06081035 0,08592232 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,06081035 0,08587265 ! sensory perception of pain GO:0019233 33 21 0,000 0,06081035 0,08582304 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,06081035 0,08577349 ! diencephalon development GO:0021536 36 21 0,000 0,06081035 0,085724 ! collagen fibril organization GO:0030199 62 21 0,000 0,06081035 0,08567456 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,06081035 0,08562518 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,06081035 0,08557586 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,06081035 0,08552659 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,06081035 0,08547738 ! collagen catabolic process GO:0030574 29 21 0,000 0,06081035 0,08542823 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,06081035 0,08537913 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,06081035 0,08533009 ! sperm-egg recognition GO:0035036 23 21 0,000 0,06081035 0,08528111 ! actin filament-based movement GO:0030048 47 21 0,000 0,06081035 0,08523218 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,06081035 0,08518331 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,06361288 0,08905803 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,06361288 0,08900702 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,06361288 0,08895607 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,06361288 0,08890518 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,06361288 0,08885435 ! microtubule-based transport GO:0010970 59 22 0,000 0,06361288 0,08880358 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,06361288 0,08875286 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,06361288 0,0887022 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,06361288 0,0886516 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,06361288 0,08860106 ! cellular response to starvation GO:0009267 37 22 0,000 0,06361288 0,08855057 ! vacuolar transport GO:0007034 41 22 0,000 0,06361288 0,08850015 ! central nervous system neuron development GO:0021954 47 22 0,000 0,06361288 0,08844978 ! fucose metabolic process GO:0006004 44 22 0,000 0,06361288 0,08839946 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,06361288 0,08834921 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,06361288 0,08829901 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,06361288 0,08824887 ! ureteric bud development GO:0001657 50 22 0,000 0,06361288 0,08819878 ! cell aging GO:0007569 48 22 0,000 0,06361288 0,08814876 ! stem cell differentiation GO:0048863 57 22 0,000 0,06361288 0,08809879 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,06361288 0,08804887 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,06361288 0,08799901 ! cytolysis GO:0019835 27 22 0,000 0,06361288 0,08794921 ! renal system process GO:0003014 42 22 0,000 0,06361288 0,08789947 ! vasodilation GO:0042311 40 22 0,000 0,06361288 0,08784978 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,06361288 0,08780015 ! G1 phase GO:0051318 44 22 0,000 0,06361288 0,08775057 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,06361288 0,08770105 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,06361288 0,08765158 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,06361288 0,08760217 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,06361288 0,08755282 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,06361288 0,08750352 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,06361288 0,08745428 ! sarcomere organization GO:0045214 32 22 0,000 0,06361288 0,08740509 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,06361288 0,08735596 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,06361288 0,08730689 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,06361288 0,08725787 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,06361288 0,0872089 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,06361288 0,08715999 ! gut development GO:0048565 44 22 0,000 0,06361288 0,08711113 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,06361288 0,08706233 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,06361288 0,08701358 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,06361288 0,08696489 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,06640712 0,09073411 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,06640712 0,09068339 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,06640712 0,09063273 ! gluconeogenesis GO:0006094 38 23 0,000 0,06640712 0,09058213 ! glycerol metabolic process GO:0006071 40 23 0,000 0,06640712 0,09053158 ! viral genome replication GO:0019079 44 23 0,000 0,06640712 0,09048109 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,06640712 0,09043065 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,06640712 0,09038027 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,06640712 0,09032995 ! regeneration GO:0031099 42 23 0,000 0,06640712 0,09027968 ! axis specification GO:0009798 43 23 0,000 0,06640712 0,09022947 ! visual behavior GO:0007632 46 23 0,000 0,06640712 0,09017932 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,06640712 0,09012922 ! response to ethanol GO:0045471 47 23 0,000 0,06640712 0,09007917 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,06640712 0,09002918 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,06640712 0,08997925 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,06640712 0,08992937 ! peroxisome organization GO:0007031 43 23 0,000 0,06640712 0,08987955 ! lysosome organization GO:0007040 47 23 0,000 0,06640712 0,08982978 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,06640712 0,08978007 ! vesicle targeting GO:0006903 49 23 0,000 0,06640712 0,08973041 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,06640712 0,08968081 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,06640712 0,08963126 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,06640712 0,08958177 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,06640712 0,08953233 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,06640712 0,08948295 ! DNA modification GO:0006304 36 23 0,000 0,06640712 0,08943362 ! fatty acid transport GO:0015908 47 23 0,000 0,06640712 0,08938435 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,06640712 0,08933513 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,06640712 0,08928596 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,06640712 0,08923685 ! hormone transport GO:0009914 41 23 0,000 0,06640712 0,08918779 ! cell-cell recognition GO:0009988 28 23 0,000 0,06640712 0,08913879 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,06640712 0,08908983 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,06640712 0,08904094 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,06640712 0,0889921 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,0691931 0,09267475 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,0691931 0,09262397 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,0691931 0,09257324 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,0691931 0,09252257 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,0691931 0,09247196 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,0691931 0,0924214 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,0691931 0,0923709 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,0691931 0,09232045 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,0691931 0,09227006 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,0691931 0,09221972 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,0691931 0,09216943 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,0691931 0,09211921 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,0691931 0,09206903 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,0691931 0,09201891 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,0691931 0,09196885 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,0691931 0,09191884 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,0691931 0,09186888 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,0691931 0,09181898 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,0691931 0,09176913 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,0691931 0,09171934 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,0691931 0,0916696 ! membrane depolarization GO:0051899 45 24 0,000 0,0691931 0,09161991 ! oogenesis GO:0048477 44 24 0,000 0,0691931 0,09157028 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,0691931 0,0915207 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,0691931 0,09147118 ! platelet activation GO:0030168 41 24 0,000 0,0691931 0,09142171 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,0691931 0,09137229 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,0691931 0,09132293 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,0691931 0,09127362 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,0691931 0,09122436 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,0691931 0,09117516 ! regulation of amine transport GO:0051952 41 24 0,000 0,0691931 0,09112601 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,0691931 0,09107691 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,07197085 0,09468216 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,07197085 0,0946312 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,07197085 0,0945803 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,07197085 0,09452945 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,07197085 0,09447865 ! leukocyte adhesion GO:0007159 55 25 0,000 0,07197085 0,09442791 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,07197085 0,09437723 ! phototransduction GO:0007602 37 25 0,000 0,07197085 0,0943266 ! keratinization GO:0031424 37 25 0,000 0,07197085 0,09427602 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,07197085 0,0942255 ! vacuole organization GO:0007033 49 25 0,000 0,07197085 0,09417503 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,07197085 0,09412461 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,07197085 0,09407425 ! chromosome condensation GO:0030261 48 25 0,000 0,07197085 0,09402394 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,07197085 0,09397369 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,07197085 0,09392349 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,07197085 0,09387334 ! immunoglobulin production GO:0002377 62 25 0,000 0,07197085 0,09382325 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,07197085 0,09377321 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,07197085 0,09372323 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,07197085 0,0936733 ! liver development GO:0001889 55 25 0,000 0,07197085 0,09362342 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,07474038 0,09717443 ! initiation of viral infection GO:0019059 60 26 0,000 0,07474038 0,09712274 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,07474038 0,0970711 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,07474038 0,09701953 ! molting cycle process GO:0022404 52 26 0,000 0,07474038 0,096968 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,07474038 0,09691653 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,07474038 0,09686512 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,07474038 0,09681376 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,07474038 0,09676245 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,07474038 0,0967112 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,07474038 0,09666 ! digestive system process GO:0022600 49 26 0,000 0,07474038 0,09660886 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,07474038 0,09655777 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,07474038 0,09650674 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,07474038 0,09645576 ! osteoblast differentiation GO:0001649 63 26 0,000 0,07474038 0,09640483 ! neural crest cell development GO:0014032 59 26 0,000 0,07474038 0,09635396 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,07474038 0,09630314 ! negative regulation of cell development GO:0010721 83 26 0,000 0,07474038 0,09625237 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,07474038 0,09620166 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,07474038 0,096151 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,07474038 0,09610039 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,07474038 0,09604984 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,07474038 0,09599934 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,07474038 0,0959489 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,07474038 0,0958985 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,07474038 0,09584816 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,07474038 0,09579787 ! blastocyst development GO:0001824 50 26 0,000 0,07474038 0,09574764 ! telomere organization GO:0032200 46 26 0,000 0,07474038 0,09569746 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,07474038 0,09564733 ! neural tube closure GO:0001843 58 26 0,000 0,07474038 0,09559725 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,07474038 0,09554723 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,07474038 0,09549725 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,07474038 0,09544733 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,07750173 0,09892201 ! embryonic pattern specification GO:0009880 49 27 0,000 0,07750173 0,09887035 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,07750173 0,09881875 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,07750173 0,0987672 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,07750173 0,0987157 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,07750173 0,09866426 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,07750173 0,09861287 ! iron ion transport GO:0006826 65 27 0,000 0,07750173 0,09856154 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,07750173 0,09851026 ! superoxide metabolic process GO:0006801 41 27 0,000 0,07750173 0,09845903 ! tube lumen formation GO:0035148 59 27 0,000 0,07750173 0,09840786 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,07750173 0,09835674 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,07750173 0,09830567 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,07750173 0,09825465 ! response to starvation GO:0042594 47 27 0,000 0,07750173 0,09820369 ! response to toxin GO:0009636 49 27 0,000 0,07750173 0,09815278 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,07750173 0,09810193 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,07750173 0,09805112 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,07750173 0,09800037 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,07750173 0,09794967 ! leukocyte proliferation GO:0070661 59 27 0,000 0,07750173 0,09789903 GO:0032943|mononuclear cell proliferation, ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,08025491 0,10132442 ! neuron fate commitment GO:0048663 52 28 0,000 0,08025491 0,10127208 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,08025491 0,1012198 ! protein amino acid acylation GO:0043543 59 28 0,000 0,08025491 0,10116757 ! vesicle docking GO:0048278 55 28 0,000 0,08025491 0,10111539 ! circadian rhythm GO:0007623 56 28 0,000 0,08025491 0,10106327 ! dendrite development GO:0016358 67 28 0,000 0,08025491 0,1010112 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,08025491 0,10095919 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,08025491 0,10090723 ! sperm motility GO:0030317 37 28 0,000 0,08025491 0,10085532 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,08025491 0,10080347 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,08025491 0,10075167 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,08025491 0,10069992 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,08025491 0,10064823 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,08025491 0,10059659 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,08025491 0,100545 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,08025491 0,10049346 ! glutathione metabolic process GO:0006749 42 28 0,000 0,08025491 0,10044198 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,08025491 0,10039055 ! lipid oxidation GO:0034440 48 28 0,000 0,08025491 0,10033917 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,08025491 0,10028785 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,08025491 0,10023658 ! translational initiation GO:0006413 66 29 0,000 0,08299995 0,1036121 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,08299995 0,10355919 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,08299995 0,10350632 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,08299995 0,10345351 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,08299995 0,10340076 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,08299995 0,10334806 ! primary neural tube formation GO:0014020 61 29 0,000 0,08299995 0,10329541 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,08299995 0,10324281 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,08299995 0,10319027 ! somitogenesis GO:0001756 52 29 0,000 0,08299995 0,10313779 ! synaptogenesis GO:0007416 46 29 0,000 0,08299995 0,10308535 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,08299995 0,10303297 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,08299995 0,10298064 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,08299995 0,10292837 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,08299995 0,10287615 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,08573688 0,10621461 ! phenol metabolic process GO:0018958 56 30 0,000 0,08573688 0,10616077 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,08573688 0,10610699 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,08573688 0,10605327 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,08573688 0,1059996 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,08573688 0,10594598 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,08573688 0,10589242 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,08573688 0,10583891 ! acute-phase response GO:0006953 50 30 0,000 0,08573688 0,10578546 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,08573688 0,10573206 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,08573688 0,10567871 ! myofibril assembly GO:0030239 50 30 0,000 0,08573688 0,10562542 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,08573688 0,10557218 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,08573688 0,10551899 ! cell fate determination GO:0001709 64 30 0,000 0,08573688 0,10546586 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,08573688 0,10541278 ! phospholipid transport GO:0015914 65 30 0,000 0,08573688 0,10535976 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,08573688 0,10530679 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,08573688 0,10525387 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,08573688 0,10520101 ! regulation of B cell activation GO:0050864 55 30 0,000 0,08573688 0,10514819 ! regulation of coagulation GO:0050818 52 30 0,000 0,08573688 0,10509544 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,08846572 0,10838603 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,08846572 0,1083317 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,08846572 0,10827743 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,08846572 0,10822321 ! cell junction assembly GO:0034329 85 31 0,000 0,08846572 0,10816904 ! regulation of innate immune response GO:0045088 57 31 0,000 0,08846572 0,10811493 ! ovulation cycle process GO:0022602 55 31 0,000 0,08846572 0,10806088 ! peptide transport GO:0015833 60 31 0,000 0,08846572 0,10800687 ! male gonad development GO:0008584 56 31 0,000 0,08846572 0,10795292 ! iron ion homeostasis GO:0055072 60 31 0,000 0,08846572 0,10789903 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,08846572 0,10784518 ! detection of light stimulus GO:0009583 44 31 0,000 0,08846572 0,1077914 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,08846572 0,10773766 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,08846572 0,10768398 ! natural killer cell activation GO:0030101 50 31 0,000 0,08846572 0,10763035 ! cofactor catabolic process GO:0051187 54 31 0,000 0,08846572 0,10757678 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,08846572 0,10752326 ! eye morphogenesis GO:0048592 65 31 0,000 0,08846572 0,10746979 ! response to heat GO:0009408 54 31 0,000 0,08846572 0,10741638 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,08846572 0,10736302 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,09118649 0,11061002 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,09118649 0,11055513 ! collagen metabolic process GO:0032963 49 32 0,000 0,09118649 0,11050029 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,09118649 0,11044551 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,09118649 0,11039078 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,09118649 0,1103361 ! metanephros development GO:0001656 81 32 0,000 0,09118649 0,11028148 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,09118649 0,11022691 ! muscle cell development GO:0055001 52 32 0,000 0,09118649 0,1101724 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,09118649 0,11011794 ! ovulation cycle GO:0042698 57 32 0,000 0,09118649 0,11006353 ! BMP signaling pathway GO:0030509 71 32 0,000 0,09118649 0,11000918 ! hindbrain development GO:0030902 65 32 0,000 0,09118649 0,10995488 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,09118649 0,10990063 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,09118649 0,10984644 ! gene silencing GO:0016458 71 32 0,000 0,09118649 0,1097923 ! regulation of pH GO:0006885 56 33 0,000 0,09389921 0,11300284 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,09389921 0,1129472 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,09389921 0,11289162 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,09389921 0,11283609 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,09389921 0,11278061 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,09389921 0,11272519 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,09389921 0,11266983 ! response to ionizing radiation GO:0010212 74 33 0,000 0,09389921 0,11261452 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,09389921 0,11255926 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,09389921 0,11250406 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,09389921 0,11244891 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,09389921 0,11239381 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,09389921 0,11233877 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,09389921 0,11228378 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,09660391 0,11546153 ! glial cell differentiation GO:0010001 67 34 0,000 0,09660391 0,11540506 ! post-embryonic development GO:0009791 76 34 0,000 0,09660391 0,11534866 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,09660391 0,11529231 ! cholesterol transport GO:0030301 62 34 0,000 0,09660391 0,11523601 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,09660391 0,11517977 ! spliceosome assembly GO:0000245 75 34 0,000 0,09660391 0,11512359 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,09660391 0,11506746 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,09660391 0,11501138 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,09660391 0,11495536 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,09660391 0,11489939 ! adult locomotory behavior GO:0008344 62 34 0,000 0,09660391 0,11484348 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,09930062 0,11799193 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,09930062 0,11793457 ! negative regulation of secretion GO:0051048 68 35 0,000 0,09930062 0,11787726 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,09930062 0,11782001 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,09930062 0,11776282 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,09930062 0,11770568 ! membrane docking GO:0022406 69 35 0,000 0,09930062 0,1176486 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,09930062 0,11759157 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,09930062 0,1175346 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,09930062 0,11747768 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,09930062 0,11742082 ! ceramide metabolic process GO:0006672 72 35 0,000 0,09930062 0,11736401 ! sterol transport GO:0015918 63 35 0,000 0,09930062 0,11730726 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,09930062 0,11725056 ! placenta development GO:0001890 53 35 0,000 0,09930062 0,11719392 ! vesicle localization GO:0051648 70 35 0,000 0,09930062 0,11713733 ! regulation of muscle development GO:0048634 82 36 0,000 0,10198935 0,12025095 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,10198935 0,12019295 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,10198935 0,12013499 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,10198935 0,1200771 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,10198935 0,12001926 ! positive regulation of cell development GO:0010720 85 36 0,000 0,10198935 0,11996147 ! protein targeting to membrane GO:0006612 75 36 0,000 0,10198935 0,11990374 ! regulation of proteolysis GO:0030162 77 36 0,000 0,10198935 0,11984607 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,10198935 0,11978845 ! aerobic respiration GO:0009060 56 36 0,000 0,10198935 0,11973089 ! cytokine production GO:0001816 68 36 0,000 0,10198935 0,11967338 ! embryonic organ development GO:0048568 67 36 0,000 0,10198935 0,11961593 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,10198935 0,11955853 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,10198935 0,11950119 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,10467013 0,12258347 ! sister chromatid segregation GO:0000819 65 37 0,000 0,10467013 0,12252473 ! actomyosin structure organization GO:0031032 68 37 0,000 0,10467013 0,12246605 ! cell junction organization GO:0034330 96 37 0,000 0,10467013 0,12240743 ! female gonad development GO:0008585 71 37 0,000 0,10467013 0,12234886 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,10467013 0,12229035 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,10734298 0,1253532 ! meiosis I GO:0007127 74 38 0,000 0,10734298 0,12529331 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,10734298 0,12523348 ! organic anion transport GO:0015711 82 38 0,000 0,10734298 0,1251737 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,10734298 0,12511398 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,10734298 0,12505432 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,10734298 0,12499471 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,10734298 0,12493516 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,10734298 0,12487567 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,10734298 0,12481623 ! spermatid development GO:0007286 69 38 0,000 0,10734298 0,12475685 ! glycogen metabolic process GO:0005977 63 38 0,000 0,10734298 0,12469753 ! pigment metabolic process GO:0042440 87 38 0,000 0,10734298 0,12463826 ! neural tube formation GO:0001841 79 38 0,000 0,10734298 0,12457905 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,11000793 0,12761129 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,11000793 0,12755072 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,11000793 0,12749021 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,11000793 0,12742976 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,11000793 0,12736937 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,11000793 0,12730903 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,11000793 0,12724875 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,11000793 0,12718853 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,11000793 0,12712837 ! glucan metabolic process GO:0044042 64 39 0,000 0,11000793 0,12706826 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,11266499 0,13007589 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,11266499 0,13001445 ! learning GO:0007612 82 40 0,000 0,11266499 0,12995306 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,11266499 0,12989173 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,11266499 0,12983046 ! lipid homeostasis GO:0055088 75 40 0,000 0,11266499 0,12976925 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,11266499 0,1297081 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,11266499 0,129647 ! RNA export from nucleus GO:0006405 61 41 0,000 0,1153142 0,13263305 ! mRNA catabolic process GO:0006402 79 41 0,000 0,1153142 0,13257063 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,1153142 0,13250828 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,1153142 0,13244598 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,1153142 0,13238374 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,1153142 0,13232156 ! gliogenesis GO:0042063 91 41 0,000 0,1153142 0,13225944 ! feeding behavior GO:0007631 69 41 0,000 0,1153142 0,13219737 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,1153142 0,13213537 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,1153142 0,13207342 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,1153142 0,13201153 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,1153142 0,13194969 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,1153142 0,13188792 ! RNA modification GO:0009451 64 41 0,000 0,1153142 0,1318262 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,11795558 0,13478273 ! ear morphogenesis GO:0042471 64 42 0,000 0,11795558 0,13471972 ! organic ether metabolic process GO:0018904 59 42 0,000 0,11795558 0,13465676 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,11795558 0,13459387 ! T cell differentiation GO:0030217 93 42 0,000 0,11795558 0,13453103 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,11795558 0,13446826 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,11795558 0,13440554 ! regulation of protein secretion GO:0050708 77 42 0,000 0,11795558 0,13434288 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,11795558 0,13428028 ! cytokinesis GO:0000910 84 42 0,000 0,11795558 0,13421773 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,11795558 0,13415525 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,12058914 0,13708668 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 0,000 0,12058914 0,13702291 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,12058914 0,13695921 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,12058914 0,13689557 ! regulation of tube size GO:0035150 76 43 0,000 0,12058914 0,13683199 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,12058914 0,13676846 ! glucose transport GO:0015758 66 43 0,000 0,12058914 0,136705 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,12058914 0,13664159 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,12058914 0,13657824 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,12058914 0,13651495 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,12058914 0,13645172 ! segmentation GO:0035282 78 43 0,000 0,12058914 0,13638855 ! ion transmembrane transport GO:0034220 79 43 0,000 0,12058914 0,13632544 ! neuron migration GO:0001764 85 43 0,000 0,12058914 0,13626238 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,12058914 0,13619938 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,12321491 0,13910075 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,12321491 0,1390365 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,12321491 0,13897231 ! hexose transport GO:0008645 68 44 0,000 0,12321491 0,13890818 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,12321491 0,13884411 ! striated muscle contraction GO:0006941 85 44 0,000 0,12321491 0,1387801 ! phagocytosis GO:0006909 105 44 0,000 0,12321491 0,13871614 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,12321491 0,13865225 ! double-strand break repair GO:0006302 85 44 0,000 0,12321491 0,13858841 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,12583292 0,14146793 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,12583292 0,14140286 ! induction of apoptosis by intracellular signals GO:0008629 95 45 0,000 0,12583292 0,14133785 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,12583292 0,14127289 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,12583292 0,141208 ! biopolymer methylation GO:0043414 91 45 0,000 0,12583292 0,14114317 ! B cell differentiation GO:0030183 124 45 0,000 0,12583292 0,14107839 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,12583292 0,14101368 ! female gamete generation GO:0007292 71 45 0,000 0,12583292 0,14094902 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,12583292 0,14088443 ! developmental growth GO:0048589 88 45 0,000 0,12583292 0,14081989 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,12844318 0,14367522 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,12844318 0,14360947 ! glycolysis GO:0006096 71 46 0,000 0,12844318 0,14354377 ! leukocyte migration GO:0050900 75 46 0,000 0,12844318 0,14347814 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,12844318 0,14341256 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,12844318 0,14334705 ! pigmentation GO:0043473 103 46 0,000 0,12844318 0,14328159 ! neural tube development GO:0021915 91 47 0,000 0,13104572 0,14611807 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,13104572 0,14605141 ! positive regulation of defense response GO:0031349 88 48 0,000 0,13364057 0,14887547 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,13364057 0,14880761 ! mitochondrial transport GO:0006839 94 48 0,000 0,13364057 0,14873982 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,13364057 0,14867209 ! cellular component disassembly GO:0022411 89 48 0,000 0,13364057 0,14860442 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,13364057 0,14853681 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,13364057 0,14846926 ! male sex differentiation GO:0046661 93 48 0,000 0,13364057 0,14840177 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,13364057 0,14833435 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,13364057 0,14826698 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,13364057 0,14819968 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,13364057 0,14813244 ! methylation GO:0032259 97 48 0,000 0,13364057 0,14806526 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,13622773 0,15086326 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,13622773 0,1507949 ! JNK cascade GO:0007254 106 49 0,000 0,13622773 0,15072661 ! protein homooligomerization GO:0051260 84 49 0,000 0,13622773 0,15065838 ! regulation of ion transport GO:0043269 86 50 0,000 0,13880725 0,15344168 ! endocrine system development GO:0035270 109 50 0,000 0,13880725 0,15337228 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,13880725 0,15330294 ! activation of caspase activity GO:0006919 95 50 0,000 0,13880725 0,15323367 ! regulation of ossification GO:0030278 123 50 0,000 0,13880725 0,15316446 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,13880725 0,15309531 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,13880725 0,15302622 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,13880725 0,1529572 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,13880725 0,15288823 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,13880725 0,15281933 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,14137913 0,15558073 ! viral infectious cycle GO:0019058 104 51 0,000 0,14137913 0,15551068 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,14137913 0,15544069 ! peptide metabolic process GO:0006518 80 51 0,000 0,14137913 0,15537077 ! response to temperature stimulus GO:0009266 84 51 0,000 0,14137913 0,15530091 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,14137913 0,15523111 ! positive regulation of binding GO:0051099 88 52 0,000 0,14394341 0,15797562 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,14394341 0,15790469 ! Notch signaling pathway GO:0007219 111 52 0,000 0,14394341 0,15783381 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,14394341 0,15776301 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,14394341 0,15769226 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,14394341 0,15762158 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,14394341 0,15755096 ! excretion GO:0007588 87 52 0,000 0,14394341 0,1574804 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,14394341 0,15740991 ! histone modification GO:0016570 104 52 0,000 0,14394341 0,15733948 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,14394341 0,15726911 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,14394341 0,15719881 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,14394341 0,15712857 ! amino acid activation GO:0043038 98 52 0,000 0,14394341 0,15705839 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,14650009 0,15977667 ! inner ear development GO:0048839 89 53 0,000 0,14650009 0,15970537 ! chromatin remodeling GO:0006338 122 53 0,000 0,14650009 0,15963413 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,14650009 0,15956296 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,14650009 0,15949186 ! vesicle organization GO:0016050 127 53 0,000 0,14650009 0,15942082 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,14650009 0,15934984 ! cartilage development GO:0051216 99 53 0,000 0,14650009 0,15927892 ! regulation of translational initiation GO:0006446 87 54 0,000 0,14904922 0,16197831 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,14904922 0,16190629 ! neuromuscular process GO:0050905 107 54 0,000 0,14904922 0,16183433 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,14904922 0,16176244 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,14904922 0,1616906 ! membrane fusion GO:0006944 122 54 0,000 0,14904922 0,16161884 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,14904922 0,16154713 ! covalent chromatin modification GO:0016569 115 54 0,000 0,14904922 0,1614755 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,14904922 0,16140392 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,14904922 0,16133241 ! RNA catabolic process GO:0006401 103 55 0,000 0,1515908 0,16401077 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,1515908 0,16393817 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,1515908 0,16386563 ! cell recognition GO:0008037 98 55 0,000 0,1515908 0,16379316 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,1515908 0,16372075 ! cell maturation GO:0048469 107 55 0,000 0,1515908 0,1636484 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,1515908 0,16357612 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,15412487 0,16623711 ! glucose catabolic process GO:0006007 88 56 0,000 0,15412487 0,16616375 ! RNA elongation GO:0006354 90 56 0,000 0,15412487 0,16609045 ! chloride transport GO:0006821 102 57 0,000 0,15665143 0,16873873 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,15665143 0,16866437 GO:0010952|positive regulation of peptidase activity, ! regulation of actin filament length GO:0030832 118 58 0,000 0,15917052 0,17130114 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,15917052 0,17122571 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,15917052 0,17115034 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,15917052 0,17107505 ! aging GO:0007568 112 58 0,000 0,15917052 0,17099982 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,15917052 0,17092465 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,15917052 0,17084955 ! nuclear export GO:0051168 110 59 0,000 0,16168216 0,17346926 ! establishment of organelle localization GO:0051656 122 59 0,000 0,16168216 0,17339311 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,16418636 0,17600144 ! DNA catabolic process GO:0006308 94 60 0,000 0,16418636 0,17592425 ! regulation of endocytosis GO:0030100 104 60 0,000 0,16418636 0,17584712 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,16418636 0,17577006 ! adult behavior GO:0030534 104 60 0,000 0,16418636 0,17569307 ! kidney development GO:0001822 133 60 0,000 0,16418636 0,17561615 ! regulation of cellular component size GO:0032535 125 61 0,000 0,16668316 0,17820873 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,16668316 0,17813077 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,16668316 0,17805289 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,16668316 0,17797507 ! regulation of heart contraction GO:0008016 123 61 0,000 0,16668316 0,17789731 ! camera-type eye development GO:0043010 126 61 0,000 0,16668316 0,17781963 ! proton transport GO:0015992 117 61 0,000 0,16668316 0,17774201 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,16668316 0,17766446 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,16917256 0,18023924 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,16917256 0,18016067 ! tRNA processing GO:0008033 102 62 0,000 0,16917256 0,18008216 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,1716546 0,18264468 ! regulation of mitosis GO:0007088 112 63 0,000 0,1716546 0,18256517 GO:0051783|regulation of nuclear division, ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,1716546 0,18248572 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,1716546 0,18240635 ! hydrogen transport GO:0006818 121 64 0,000 0,17412929 0,18495559 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,17412929 0,18487521 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,17412929 0,1847949 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,17659666 0,18733202 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,17659666 0,18725072 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,17659666 0,18716948 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,17659666 0,18708831 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,17659666 0,18700722 ! ear development GO:0043583 114 66 0,000 0,17905673 0,18953016 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,17905673 0,18944807 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,17905673 0,18936606 ! gonad development GO:0008406 115 66 0,000 0,17905673 0,18928412 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,18150952 0,19179401 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,18150952 0,19171109 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,18150952 0,19162824 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,18150952 0,19154547 ! secondary metabolic process GO:0019748 125 67 0,000 0,18150952 0,19146276 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,18150952 0,19138013 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,18395505 0,19387497 ! hexose catabolic process GO:0019320 113 68 0,000 0,18395505 0,19379137 ! extracellular matrix organization GO:0030198 146 68 0,000 0,18395505 0,19370784 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,18395505 0,19362438 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,18395505 0,19354099 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,18395505 0,19345768 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,18395505 0,19337443 ! cell projection assembly GO:0030031 138 68 0,000 0,18395505 0,19329126 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,18639334 0,1957691 ! negative regulation of protein kinase activity GO:0006469 144 69 0,000 0,18639334 0,19568497 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,18639334 0,19560091 ! urogenital system development GO:0001655 149 69 0,000 0,18639334 0,19551693 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,18639334 0,19543301 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,18639334 0,19534917 ! developmental maturation GO:0021700 128 69 0,000 0,18639334 0,1952654 ! single fertilization GO:0007338 83 69 0,000 0,18639334 0,19518171 ! negative regulation of kinase activity GO:0033673 145 70 0,000 0,18882441 0,19764269 ! cell redox homeostasis GO:0045454 114 70 0,000 0,18882441 0,19755804 ! germ cell development GO:0007281 133 70 0,000 0,18882441 0,19747347 ! activation of immune response GO:0002253 120 70 0,000 0,18882441 0,19738898 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,18882441 0,19730455 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,19124829 0,19975185 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,19124829 0,19966648 ! appendage morphogenesis GO:0035107 150 72 0,000 0,19366499 0,20210319 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,19366499 0,2020169 ! B cell activation GO:0042113 179 72 0,000 0,19366499 0,20193067 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,19366499 0,20184453 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,19366499 0,20175845 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,19366499 0,20167245 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,19366499 0,20158652 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,19366499 0,20150067 ! appendage development GO:0048736 151 73 0,000 0,19607454 0,20392086 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,19607454 0,20383408 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,19607454 0,20374738 ! regulation of immune effector process GO:0002697 156 73 0,000 0,19607454 0,20366076 ! acute inflammatory response GO:0002526 118 74 0,000 0,19847695 0,20606851 ! amino acid transport GO:0006865 148 74 0,000 0,19847695 0,20598097 ! regulation of caspase activity GO:0043281 136 74 0,000 0,19847695 0,2058935 ! negative regulation of transferase activity GO:0051348 155 74 0,000 0,19847695 0,20580611 ! transition metal ion transport GO:0000041 143 75 0,000 0,20087226 0,2082015 ! reproductive structure development GO:0048608 131 75 0,000 0,20087226 0,2081132 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,20087226 0,20802498 ! eye development GO:0001654 155 75 0,000 0,20087226 0,20793683 ! rhythmic process GO:0048511 142 75 0,000 0,20087226 0,20784876 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,20326047 0,21023088 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,20326047 0,21014191 ! learning or memory GO:0007611 161 76 0,000 0,20326047 0,21005302 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,20326047 0,2099642 ! regulation of blood pressure GO:0008217 134 76 0,000 0,20326047 0,20987546 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,20326047 0,20978679 ! amine catabolic process GO:0009310 136 77 0,000 0,20564162 0,21215476 ! neurotransmitter transport GO:0006836 142 77 0,000 0,20564162 0,2120652 ! regulation of endopeptidase activity GO:0052548 141 77 0,000 0,20564162 0,21197572 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,20564162 0,21188632 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,20564162 0,21179699 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,20564162 0,21170774 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,20564162 0,21161856 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,20801571 0,21397153 ! antigen processing and presentation GO:0019882 117 78 0,000 0,20801571 0,21388147 ! fertilization GO:0009566 99 78 0,000 0,20801571 0,21379149 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,20801571 0,21370159 ! blood coagulation GO:0007596 151 79 0,000 0,21038277 0,2160425 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,21038277 0,21595173 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,21038277 0,21586103 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,21038277 0,21577041 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,21038277 0,21567986 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,21038277 0,2155894 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,21274283 0,21791645 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,21274283 0,21782512 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,21274283 0,21773387 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,21274283 0,21764269 ! meiosis GO:0007126 143 81 0,000 0,2150959 0,21995784 GO:0051327|M phase of meiotic cell cycle, ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,2150959 0,21986581 ! regulation of peptidase activity GO:0052547 150 82 0,000 0,217442 0,22217098 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,217442 0,2220781 ! protein import into nucleus GO:0006606 174 82 0,000 0,217442 0,2219853 ! meiotic cell cycle GO:0051321 144 82 0,000 0,217442 0,22189257 ! exocytosis GO:0006887 153 83 0,000 0,21978116 0,22418596 ! response to drug GO:0042493 149 83 0,000 0,21978116 0,22409239 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,21978116 0,2239989 ! nuclear import GO:0051170 177 83 0,000 0,21978116 0,22390549 ! inorganic anion transport GO:0015698 156 83 0,000 0,21978116 0,22381216 ! T cell activation GO:0042110 189 84 0,000 0,22211339 0,22609292 ! response to nutrient GO:0007584 135 84 0,000 0,22211339 0,22599875 ! digestion GO:0007586 130 84 0,000 0,22211339 0,22590467 ! regulation of ligase activity GO:0051340 147 84 0,000 0,22211339 0,22581066 ! hemostasis GO:0007599 165 85 0,000 0,22443871 0,22807977 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,22443871 0,22798494 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,22443871 0,22789018 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,22443871 0,2277955 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,22675715 0,23005304 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,22906872 0,23230174 ! mitochondrion organization GO:0007005 159 87 0,000 0,22906872 0,23220535 ! alcohol catabolic process GO:0046164 142 87 0,000 0,22906872 0,23210904 ! nucleosome assembly GO:0006334 126 87 0,000 0,22906872 0,23201281 ! cellular respiration GO:0045333 143 88 0,000 0,23137345 0,23425004 ! amine biosynthetic process GO:0009309 146 88 0,000 0,23137345 0,234153 ! sensory perception of smell GO:0007608 117 88 0,000 0,23137345 0,23405604 ! chromatin assembly GO:0031497 128 88 0,000 0,23137345 0,23395916 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,23137345 0,23386237 ! tube morphogenesis GO:0035239 194 89 0,000 0,23367135 0,23608731 ! cellular defense response GO:0006968 123 89 0,000 0,23367135 0,23598971 ! protein localization in nucleus GO:0034504 192 89 0,000 0,23367135 0,2358922 ! regulation of neurological system process GO:0031644 175 89 0,000 0,23367135 0,23579476 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,23596245 0,23800837 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,23596245 0,23791014 ! defense response to bacterium GO:0042742 112 91 0,000 0,23824676 0,24011421 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,24052431 0,24230964 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,24279511 0,24449648 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,24279511 0,24439574 ! vitamin metabolic process GO:0006766 153 93 0,000 0,24279511 0,24429508 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,24505918 0,24647163 ! female pregnancy GO:0007565 166 94 0,000 0,24505918 0,2463702 ! sterol metabolic process GO:0016125 166 94 0,000 0,24505918 0,24626885 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,24505918 0,24616759 ! regulation of defense response GO:0031347 171 95 0,000 0,24731655 0,24833306 ! nucleosome organization GO:0034728 143 95 0,000 0,24731655 0,24823103 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,24731655 0,24812909 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,24731655 0,24802723 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,24731655 0,24792546 ! sex differentiation GO:0007548 171 96 0,000 0,24956723 0,25007906 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,25181125 0,25222422 ! transcription initiation GO:0006352 171 97 0,000 0,25181125 0,25212085 ! leukocyte differentiation GO:0002521 232 98 0,000 0,25404862 0,25425677 ! positive regulation of immune response GO:0050778 175 100 0,000 0,25850349 0,25860935 ! hormone metabolic process GO:0042445 171 100 0,000 0,25850349 0,25850349