pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6573-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 2,000 2,716E-07 6,635E-04 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! negative regulation of T cell activation GO:0050868 41 20 3,000 3,761E-07 4,594E-04 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 2,000 5,42E-07 4,414E-04 ! negative regulation of T cell differentiation GO:0045581 14 6 2,000 5,42E-07 3,31E-04 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 2,000 9,464E-07 4,624E-04 ! cytokine-mediated signaling pathway GO:0019221 112 61 4,000 1,226E-06 4,99E-04 ! negative regulation of lymphocyte activation GO:0051250 55 27 3,000 1,34E-06 4,678E-04 ! protein amino acid autophosphorylation GO:0046777 157 64 4,000 1,559E-06 4,762E-04 ! regulation of T-helper 1 type immune response GO:0002825 12 9 2,000 2,261E-06 6,138E-04 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 2,000 2,261E-06 5,524E-04 ! negative regulation of leukocyte activation GO:0002695 60 31 3,000 2,381E-06 5,287E-04 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 2,000 4,422E-06 9,003E-04 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 4,000 4,731E-06 8,89E-04 ! negative regulation of cell activation GO:0050866 69 37 3,000 4,927E-06 8,598E-04 ! Golgi organization GO:0007030 25 13 2,000 7,631E-06 1,243E-03 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 2,000 7,631E-06 1,165E-03 ! regulation of T cell differentiation GO:0045580 78 42 3,000 8,253E-06 1,186E-03 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 2,000 9,691E-06 1,315E-03 ! regulation of T-helper 2 type immune response GO:0002828 25 14 2,000 9,691E-06 1,246E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 1,484E-05 1,813E-03 ! regulation of T-helper cell differentiation GO:0045622 30 16 2,000 1,484E-05 1,727E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 1,537E-05 1,707E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 2,000 1,798E-05 1,91E-03 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 2,000 1,798E-05 1,831E-03 ! negative regulation of immune system process GO:0002683 101 51 3,000 1,804E-05 1,763E-03 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 2,000 2,153E-05 2,023E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 2,995E-05 2,71E-03 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 2,000 3,486E-05 3,042E-03 ! viral reproductive process GO:0022415 132 62 3,000 3,926E-05 3,307E-03 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 2,000 4,028E-05 3,28E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 4,028E-05 3,174E-03 ! viral genome replication GO:0019079 44 23 2,000 4,622E-05 3,529E-03 ! viral reproduction GO:0016032 142 68 3,000 5,651E-05 4,184E-03 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 5,976E-05 4,294E-03 ! regulation of alpha-beta T cell activation GO:0046634 48 25 2,000 5,976E-05 4,171E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 6,741E-05 4,574E-03 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 2,000 7,566E-05 4,996E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 7,566E-05 4,864E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 8,456E-05 5,297E-03 ! positive regulation of T cell differentiation GO:0045582 48 28 2,000 8,456E-05 5,164E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 8,456E-05 5,038E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 9,093E-05 5,289E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 9,093E-05 5,166E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 9,093E-05 5,049E-03 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 1,000 9,093E-05 4,936E-03 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 9,41E-05 4,998E-03 ! iron ion homeostasis GO:0055072 60 31 2,000 1,153E-04 5,991E-03 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 1,269E-04 6,458E-03 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 2,000 1,269E-04 6,327E-03 ! forebrain regionalization GO:0021871 9 6 1,000 1,361E-04 6,651E-03 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 1,000 1,361E-04 6,52E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 1,361E-04 6,395E-03 GO:0051653|spindle localization, ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 1,361E-04 6,274E-03 ! ectodermal gut morphogenesis GO:0048567 16 6 1,000 1,361E-04 6,158E-03 GO:0007439|ectodermal gut development, ! gland development GO:0048732 220 91 3,000 1,758E-04 7,808E-03 ! SMAD protein complex assembly GO:0007183 13 7 1,000 1,902E-04 8,297E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 1,902E-04 8,151E-03 ! spinal cord patterning GO:0021511 14 7 1,000 1,902E-04 8,011E-03 ! microtubule nucleation GO:0007020 21 7 1,000 1,902E-04 7,875E-03 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 1,902E-04 7,744E-03 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 1,000 1,902E-04 7,617E-03 ! embryonic heart tube development GO:0035050 14 7 1,000 1,902E-04 7,494E-03 ! odontogenesis GO:0042476 74 37 2,000 1,966E-04 7,624E-03 ! regulation of T cell activation GO:0050863 175 96 3,000 2,16E-04 8,244E-03 ! mammary gland development GO:0030879 93 40 2,000 2,483E-04 9,334E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 2,531E-04 9,368E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 2,531E-04 9,228E-03 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 2,531E-04 9,092E-03 ! osteoblast development GO:0002076 17 8 1,000 2,531E-04 8,961E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 2,531E-04 8,833E-03 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 2,873E-04 9,885E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 3,247E-04 0,0110188 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 3,247E-04 0,01086786 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 3,247E-04 0,010721 ! regulation of telomere maintenance GO:0032204 17 9 1,000 3,247E-04 0,01057805 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 3,528E-04 0,01133934 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 2,000 3,528E-04 0,01119207 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 3,765E-04 0,01179337 ! pigmentation GO:0043473 103 46 2,000 3,765E-04 0,01164409 ! positive regulation of protein transport GO:0051222 80 46 2,000 3,765E-04 0,01149853 ! SMAD protein nuclear translocation GO:0007184 21 10 1,000 4,051E-04 0,01221881 ! smoothened signaling pathway GO:0007224 18 10 1,000 4,051E-04 0,0120698 ! motor axon guidance GO:0008045 22 10 1,000 4,051E-04 0,01192438 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 4,051E-04 0,01178242 ! midbrain development GO:0030901 14 10 1,000 4,051E-04 0,01164381 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 4,051E-04 0,01150841 ! regulation of adaptive immune response GO:0002819 92 48 2,000 4,271E-04 0,0119942 ! activation of caspase activity GO:0006919 95 50 2,000 4,819E-04 0,01337835 ! neuron fate specification GO:0048665 18 11 1,000 4,942E-04 0,01356473 ! thyroid gland development GO:0030878 26 11 1,000 4,942E-04 0,01341401 ! detection of mechanical stimulus GO:0050982 22 11 1,000 4,942E-04 0,01326661 ! embryonic gut development GO:0048566 19 11 1,000 4,942E-04 0,01312241 ! viral infectious cycle GO:0019058 104 51 2,000 5,109E-04 0,01342065 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 5,41E-04 0,01405978 ! virus-host interaction GO:0019048 30 12 1,000 5,918E-04 0,01521936 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 5,918E-04 0,01506082 ! ventral spinal cord development GO:0021517 25 12 1,000 5,918E-04 0,01490556 ! cranial nerve development GO:0021545 23 12 1,000 5,918E-04 0,01475346 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 5,918E-04 0,01460443 GO:0042130|negative regulation of T cell proliferation, ! regulation of angiogenesis GO:0045765 125 54 2,000 6,045E-04 0,01476799 ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 6,98E-04 0,01688445 ! digestive tract morphogenesis GO:0048546 31 13 1,000 6,98E-04 0,01671891 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! positive regulation of caspase activity GO:0043280 108 57 2,000 7,084E-04 0,01680219 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 2,000 7,084E-04 0,01664063 ! positive regulation of cell migration GO:0030335 137 58 2,000 7,454E-04 0,01734293 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 8,128E-04 0,01873212 GO:0060675|ureteric bud morphogenesis, ! male genitalia development GO:0030539 26 14 1,000 8,128E-04 0,01855706 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 8,128E-04 0,01838523 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 9,36E-04 0,02097743 ! skeletal system morphogenesis GO:0048705 118 63 2,000 9,488E-04 0,02107214 ! positive regulation of cell motion GO:0051272 157 65 2,000 1,039E-03 0,02286854 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 1,068E-03 0,02328579 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of cell growth GO:0030308 142 67 2,000 1,135E-03 0,02452844 ! chromosome segregation GO:0007059 127 67 2,000 1,135E-03 0,02431328 ! positive regulation of T cell activation GO:0050870 124 68 2,000 1,184E-03 0,02515884 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 1,207E-03 0,02543004 ! regulation of survival gene product expression GO:0045884 38 17 1,000 1,207E-03 0,02521269 ! induction of apoptosis via death domain receptors GO:0008625 23 17 1,000 1,207E-03 0,02499902 ! genitalia development GO:0048806 32 17 1,000 1,207E-03 0,02478895 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 1,207E-03 0,02458237 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 1,000 1,207E-03 0,02437921 ! negative regulation of cell size GO:0045792 144 69 2,000 1,235E-03 0,02473879 ! lung development GO:0030324 165 69 2,000 1,235E-03 0,02453766 ! patterning of blood vessels GO:0001569 43 18 1,000 1,356E-03 0,02671004 ! nerve development GO:0021675 34 18 1,000 1,356E-03 0,02649636 ! respiratory tube development GO:0030323 171 72 2,000 1,397E-03 0,02708686 ! regulation of caspase activity GO:0043281 136 74 2,000 1,512E-03 0,02908133 ! respiratory system development GO:0060541 175 74 2,000 1,512E-03 0,02885413 ! protein amino acid ADP-ribosylation GO:0006471 37 19 1,000 1,512E-03 0,02863848 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 1,512E-03 0,02841818 ! pigmentation during development GO:0048066 42 19 1,000 1,512E-03 0,02820125 ! neuromuscular junction development GO:0007528 43 19 1,000 1,512E-03 0,02798761 ! response to lipopolysaccharide GO:0032496 34 19 1,000 1,512E-03 0,02777717 ! proximal/distal pattern formation GO:0009954 33 19 1,000 1,512E-03 0,02756988 ! embryonic organ morphogenesis GO:0048562 34 19 1,000 1,512E-03 0,02736566 ! response to alkaloid GO:0043279 38 20 1,000 1,677E-03 0,03012294 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 1,677E-03 0,02990306 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 1,677E-03 0,02968637 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 1,695E-03 0,02978643 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 1,759E-03 0,03068911 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 1,85E-03 0,03204955 ! negative regulation of angiogenesis GO:0016525 49 21 1,000 1,85E-03 0,03182385 ! positive regulation of osteoblast differentiation GO:0045669 52 21 1,000 1,85E-03 0,03160131 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 1,85E-03 0,03138186 ! negative regulation of organelle organization GO:0010639 181 80 2,000 1,891E-03 0,03186025 ! regulation of peptidase activity GO:0052547 150 82 2,000 2,029E-03 0,03395737 ! protein import into nucleus GO:0006606 174 82 2,000 2,029E-03 0,03372637 ! apoptotic nuclear changes GO:0030262 34 22 1,000 2,031E-03 0,03352058 ! ureteric bud development GO:0001657 50 22 1,000 2,031E-03 0,03329561 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 2,031E-03 0,03307364 ! G1 phase GO:0051318 44 22 1,000 2,031E-03 0,03285461 ! gut development GO:0048565 44 22 1,000 2,031E-03 0,03263846 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 2,031E-03 0,03242513 ! nuclear import GO:0051170 177 83 2,000 2,101E-03 0,03332735 ! positive regulation of DNA replication GO:0045740 44 23 1,000 2,22E-03 0,03498563 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 2,22E-03 0,03476136 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 2,22E-03 0,03453995 ! response to molecule of bacterial origin GO:0002237 40 23 1,000 2,22E-03 0,03432134 ! negative regulation of growth GO:0045926 168 85 2,000 2,248E-03 0,03454754 ! positive regulation of cell activation GO:0050867 161 86 2,000 2,325E-03 0,03549453 GO:0002696|positive regulation of leukocyte activation, ! regulation of protein transport GO:0051223 165 87 2,000 2,402E-03 0,03645377 GO:0070201|regulation of establishment of protein localization, ! positive regulation of cell adhesion GO:0045785 61 24 1,000 2,417E-03 0,03644473 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 2,417E-03 0,03622114 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 2,417E-03 0,03600028 ! barbed-end actin filament capping GO:0051016 58 24 1,000 2,417E-03 0,0357821 GO:0051693|actin filament capping, ! protein localization in nucleus GO:0034504 192 89 2,000 2,563E-03 0,03771464 ! tube morphogenesis GO:0035239 194 89 2,000 2,563E-03 0,0374888 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 2,622E-03 0,03812349 ! interaction with host GO:0051701 66 25 1,000 2,622E-03 0,03789791 ! liver development GO:0001889 55 25 1,000 2,622E-03 0,03767498 ! myelination GO:0042552 50 26 1,000 2,835E-03 0,04049563 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 2,835E-03 0,04026019 ! spinal cord development GO:0021510 54 26 1,000 2,835E-03 0,04002747 ! osteoblast differentiation GO:0001649 63 26 1,000 2,835E-03 0,03979743 ! positive regulation of nuclear division GO:0051785 41 26 1,000 2,835E-03 0,03957001 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 2,835E-03 0,03934518 ! positive regulation of MAP kinase activity GO:0043406 174 93 2,000 2,903E-03 0,04006409 ! negative regulation of actin filament depolymerization GO:0030835 63 27 1,000 3,055E-03 0,04193227 ! negative regulation of actin filament polymerization GO:0030837 61 27 1,000 3,055E-03 0,04169802 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 3,269E-03 0,04437136 ! regulation of protein localization GO:0032880 188 97 2,000 3,269E-03 0,04412621 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 3,284E-03 0,04407805 ! neuron fate commitment GO:0048663 52 28 1,000 3,284E-03 0,04383718 ! negative regulation of protein polymerization GO:0032272 63 28 1,000 3,284E-03 0,04359894 ! forebrain development GO:0030900 210 98 2,000 3,365E-03 0,04443799 ! regulation of actin filament depolymerization GO:0030834 67 30 1,000 3,764E-03 0,0494379 ! negative regulation of protein complex assembly GO:0031333 68 30 1,000 3,764E-03 0,04917353 ! ensheathment of neurons GO:0007272 64 31 1,000 4,016E-03 0,05218192 GO:0008366|axon ensheathment, ! eye morphogenesis GO:0048592 65 31 1,000 4,016E-03 0,05190583 ! response to heat GO:0009408 54 31 1,000 4,016E-03 0,05163264 ! erythrocyte differentiation GO:0030218 62 31 1,000 4,016E-03 0,05136231 ! spindle organization GO:0007051 50 32 1,000 4,275E-03 0,05439348 ! metanephros development GO:0001656 81 32 1,000 4,275E-03 0,05411165 ! response to mechanical stimulus GO:0009612 60 32 1,000 4,275E-03 0,05383272 ! peripheral nervous system development GO:0007422 68 32 1,000 4,275E-03 0,05355665 ! BMP signaling pathway GO:0030509 71 32 1,000 4,275E-03 0,05328341 ! hindbrain development GO:0030902 65 32 1,000 4,275E-03 0,05301293 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 4,542E-03 0,05603724 ! cell fate specification GO:0001708 56 34 1,000 4,816E-03 0,05912342 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 4,816E-03 0,05882781 ! mRNA export from nucleus GO:0006406 53 35 1,000 5,098E-03 0,06196019 ! telencephalon development GO:0021537 81 35 1,000 5,098E-03 0,06165345 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 5,387E-03 0,06483038 ! embryonic organ development GO:0048568 67 36 1,000 5,387E-03 0,06451258 ! sister chromatid segregation GO:0000819 65 37 1,000 5,684E-03 0,06773245 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 5,684E-03 0,06740366 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 5,988E-03 0,07066495 ! meiosis I GO:0007127 74 38 1,000 5,988E-03 0,07032521 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 5,988E-03 0,06998873 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 5,988E-03 0,06965545 ! glycogen metabolic process GO:0005977 63 38 1,000 5,988E-03 0,06932533 ! erythrocyte homeostasis GO:0034101 75 39 1,000 6,299E-03 0,07258456 ! glucan metabolic process GO:0044042 64 39 1,000 6,299E-03 0,07224378 GO:0006073|cellular glucan metabolic process, ! nucleus organization GO:0006997 73 40 1,000 6,617E-03 0,07554152 ! regulation of action potential in neuron GO:0019228 80 40 1,000 6,617E-03 0,07519017 ! RNA export from nucleus GO:0006405 61 41 1,000 6,943E-03 0,07852505 ! ear morphogenesis GO:0042471 64 42 1,000 7,276E-03 0,08190963 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 7,276E-03 0,0815339 ! cytokinesis GO:0000910 84 42 1,000 7,276E-03 0,0811616 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 1,000 7,616E-03 0,08456686 ! striated muscle cell differentiation GO:0051146 91 43 1,000 7,616E-03 0,08418421 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 7,616E-03 0,083805 ! regulation of T cell proliferation GO:0042129 80 43 1,000 7,616E-03 0,08342919 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 7,616E-03 0,08305674 ! energy reserve metabolic process GO:0006112 76 44 1,000 7,962E-03 0,0864545 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 7,962E-03 0,08607196 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 7,962E-03 0,08569279 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 8,316E-03 0,08910937 ! induction of apoptosis by intracellular signals GO:0008629 95 45 1,000 8,316E-03 0,08872024 ! developmental growth GO:0048589 88 45 1,000 8,316E-03 0,0883345 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 8,677E-03 0,09176892 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 1,000 8,677E-03 0,09137336 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 8,677E-03 0,0909812 ! neural tube development GO:0021915 91 47 1,000 9,045E-03 0,0944325 ! positive regulation of cell cycle GO:0045787 96 48 1,000 9,42E-03 0,09792589 ! cellular component disassembly GO:0022411 89 48 1,000 9,42E-03 0,09751095 ! male sex differentiation GO:0046661 93 48 1,000 9,42E-03 0,09709951 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 9,801E-03 0,10060776 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 9,801E-03 0,10018681 ! regulation of action potential GO:0001508 102 50 1,000 0,01018964 0,10372203 ! induction of apoptosis by extracellular signals GO:0008624 99 50 1,000 0,01018964 0,10329165 ! endocrine system development GO:0035270 109 50 1,000 0,01018964 0,10286482 ! regulation of ossification GO:0030278 123 50 1,000 0,01018964 0,10244151 ! response to temperature stimulus GO:0009266 84 51 1,000 0,01058469 0,10597703 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,01058469 0,10554447 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,01098644 0,10910515 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 1,000 0,01139484 0,11270281 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 0,01139484 0,11224836 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! synapse organization GO:0050808 102 53 1,000 0,01139484 0,11179757 ! regulation of translational initiation GO:0006446 87 54 1,000 0,01180985 0,11540588 ! embryonic skeletal system development GO:0048706 101 54 1,000 0,01180985 0,1149461 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,01180985 0,11448996 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,01223143 0,11810827 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,01223143 0,11764328 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,01265954 0,12128334 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,01265954 0,12080958 ! regulation of DNA replication GO:0006275 105 56 1,000 0,01265954 0,1203395 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,01309413 0,12398817 ! muscle fiber development GO:0048747 131 57 1,000 0,01309413 0,12350945 ! regulation of actin filament length GO:0030832 118 58 1,000 0,01353515 0,12717836 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,01353515 0,12669109 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,01353515 0,12620754 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,01353515 0,12572766 ! nuclear export GO:0051168 110 59 1,000 0,01398257 0,12939177 ! establishment of organelle localization GO:0051656 122 59 1,000 0,01398257 0,1289035 ! DNA catabolic process GO:0006308 94 60 1,000 0,01443635 0,13258649 ! kidney development GO:0001822 133 60 1,000 0,01443635 0,13208991 ! regulation of cellular component size GO:0032535 125 61 1,000 0,01489644 0,13579107 ! camera-type eye development GO:0043010 126 61 1,000 0,01489644 0,13528627 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01510124 0,13663824 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01510124 0,13613404 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01510124 0,13563355 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01510124 0,13513672 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01510124 0,13464352 ! neuron fate determination GO:0048664 7 5 0,000 0,01510124 0,13415391 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01510124 0,13366784 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01510124 0,13318529 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01510124 0,1327062 ! polyol transport GO:0015791 12 5 0,000 0,01510124 0,13223055 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01510124 0,1317583 ! response to superoxide GO:0000303 10 5 0,000 0,01510124 0,13128941 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01510124 0,13082385 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01510124 0,13036157 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01510124 0,12990255 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01510124 0,12944675 ! female meiosis GO:0007143 10 5 0,000 0,01510124 0,12899414 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01510124 0,12854469 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01510124 0,12809835 ! hypothalamus development GO:0021854 9 5 0,000 0,01510124 0,1276551 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01510124 0,12721491 ! cobalt ion transport GO:0006824 11 5 0,000 0,01510124 0,12677775 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01510124 0,12634358 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01510124 0,12591237 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01510124 0,1254841 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01510124 0,12505873 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01510124 0,12463623 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01510124 0,12421658 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01510124 0,12379975 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01510124 0,1233857 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01510124 0,12297442 ! transposition GO:0032196 9 5 0,000 0,01510124 0,12256586 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01510124 0,12216002 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01510124 0,12175685 ! negative chemotaxis GO:0050919 16 5 0,000 0,01510124 0,12135633 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01510124 0,12095844 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01510124 0,12056315 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01510124 0,12017044 ! behavioral response to pain GO:0048266 10 5 0,000 0,01510124 0,11978028 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01510124 0,11939264 ! Notch receptor processing GO:0007220 11 5 0,000 0,01510124 0,1190075 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01510124 0,11862484 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01510124 0,11824463 ! micturition GO:0060073 9 5 0,000 0,01510124 0,11786685 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01510124 0,11749148 ! copulation GO:0007620 9 5 0,000 0,01510124 0,11711849 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01510124 0,11674786 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01510124 0,11637957 ! bioluminescence GO:0008218 9 5 0,000 0,01510124 0,1160136 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01510124 0,11564992 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01510124 0,11528852 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01510124 0,11492936 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01510124 0,11457244 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01510124 0,11421772 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01510124 0,1138652 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01510124 0,11351485 ! grooming behavior GO:0007625 6 5 0,000 0,01510124 0,11316664 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01510124 0,11282057 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01510124 0,1124766 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01510124 0,11213473 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01510124 0,11179492 ! response to protozoan GO:0001562 13 5 0,000 0,01510124 0,11145717 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,01510124 0,11112146 ! lymph vessel development GO:0001945 10 5 0,000 0,01510124 0,11078776 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01510124 0,11045606 ! endochondral ossification GO:0001958 17 5 0,000 0,01510124 0,11012634 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01510124 0,10979859 ! single strand break repair GO:0000012 8 5 0,000 0,01510124 0,10947277 ! parathyroid gland development GO:0060017 14 5 0,000 0,01510124 0,10914889 ! anagen GO:0042640 7 5 0,000 0,01510124 0,10882692 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01510124 0,10850684 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01510124 0,10818864 ! cytokine secretion GO:0050663 15 5 0,000 0,01510124 0,10787229 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01510124 0,1075578 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01510124 0,10724513 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01510124 0,10693427 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01510124 0,10662522 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01510124 0,10631794 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01510124 0,10601243 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01510124 0,10570867 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01510124 0,10540664 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01510124 0,10510634 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01510124 0,10480774 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01510124 0,10451084 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01510124 0,10421561 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01510124 0,10392204 ! microvillus organization GO:0032528 8 5 0,000 0,01510124 0,10363013 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01510124 0,10333985 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01510124 0,10305119 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01510124 0,10276414 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01510124 0,10247868 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01510124 0,10219481 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01510124 0,1019125 ! polyol catabolic process GO:0046174 9 5 0,000 0,01510124 0,10163175 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01510124 0,10135254 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01510124 0,10107486 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01510124 0,1007987 ! muscle cell migration GO:0014812 8 5 0,000 0,01510124 0,10052405 ! mitochondrial fission GO:0000266 8 5 0,000 0,01510124 0,10025088 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01510124 0,0999792 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01510124 0,09970899 ! mRNA transcription GO:0009299 10 5 0,000 0,01510124 0,09944023 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01510124 0,09917292 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01510124 0,09890704 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01510124 0,09864258 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01510124 0,09837953 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01510124 0,09811789 ! monocyte activation GO:0042117 10 5 0,000 0,01510124 0,09785763 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01510124 0,09759874 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01510124 0,09734123 ! response to food GO:0032094 6 5 0,000 0,01510124 0,09708507 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01510124 0,09683025 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01510124 0,09657677 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01510124 0,09632461 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01510124 0,09607376 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,01510124 0,09582422 ! forebrain neuron development GO:0021884 13 5 0,000 0,01510124 0,09557597 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01510124 0,095329 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01510124 0,09508331 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01510124 0,09483888 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01510124 0,0945957 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01510124 0,09435377 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01510124 0,09411307 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01510124 0,0938736 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01510124 0,09363534 ! lipid glycosylation GO:0030259 7 5 0,000 0,01510124 0,09339829 ! nucleobase transport GO:0015851 6 5 0,000 0,01510124 0,09316244 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01510124 0,09292777 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01510124 0,09269428 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01510124 0,09246197 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01510124 0,09223081 ! basic amino acid transport GO:0015802 12 5 0,000 0,01510124 0,09200081 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01510124 0,09177195 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01510124 0,09154423 ! actin nucleation GO:0045010 11 5 0,000 0,01510124 0,09131764 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01510124 0,09109216 ! depurination GO:0045007 5 5 0,000 0,01510124 0,0908678 ! depyrimidination GO:0045008 10 5 0,000 0,01510124 0,09064453 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01510124 0,09042236 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01510124 0,09020128 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01510124 0,08998128 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01510124 0,08976235 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01510124 0,08954448 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01510124 0,08932766 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01510124 0,0891119 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01510124 0,08889717 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01510124 0,08868347 ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01510124 0,0884708 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01510124 0,08825915 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01510124 0,08804851 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01510124 0,08783887 ! response to arsenic GO:0046685 11 5 0,000 0,01510124 0,08763023 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01510124 0,08742257 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01510124 0,0872159 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01510124 0,0870102 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01510124 0,08680547 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01510124 0,0866017 ! response to mercury ion GO:0046689 8 5 0,000 0,01510124 0,08639889 ! response to cadmium ion GO:0046686 7 5 0,000 0,01510124 0,08619702 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01510124 0,0859961 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01510124 0,0857961 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01510124 0,08559704 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01510124 0,0853989 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01510124 0,08520167 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01510124 0,08500536 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01510124 0,08480994 ! decidualization GO:0046697 11 5 0,000 0,01510124 0,08461542 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01510124 0,0844218 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01510124 0,08422905 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01510124 0,08403719 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01510124 0,08384619 ! embryonic cleavage GO:0040016 6 5 0,000 0,01510124 0,08365607 ! peroxisome fission GO:0016559 5 5 0,000 0,01510124 0,0834668 ! histone demethylation GO:0016577 13 5 0,000 0,01510124 0,08327839 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01510124 0,08309082 ! mitotic recombination GO:0006312 9 5 0,000 0,01510124 0,0829041 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01510124 0,08271822 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01510124 0,08253317 ! metaphase plate congression GO:0051310 7 5 0,000 0,01510124 0,08234894 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01510124 0,08216553 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01510124 0,08198294 ! enteric nervous system development GO:0048484 8 5 0,000 0,01510124 0,08180116 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01510124 0,08162019 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01510124 0,08144001 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01510124 0,08126063 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01510124 0,08108203 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01510124 0,08090422 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01510124 0,08072719 ! B cell homeostasis GO:0001782 13 5 0,000 0,01510124 0,08055093 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01510124 0,08037544 ! metaphase GO:0051323 11 5 0,000 0,01510124 0,08020071 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01510124 0,08002673 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01510124 0,07985352 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01510124 0,07968105 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01510124 0,07950932 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01510124 0,07933833 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01510124 0,07916808 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01510124 0,07899855 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01510124 0,07882975 ! response to redox state GO:0051775 6 5 0,000 0,01510124 0,07866167 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01510124 0,07849431 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01510124 0,07832765 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01510124 0,07816171 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01510124 0,07799646 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01510124 0,07783191 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01510124 0,07766805 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01510124 0,07750488 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01510124 0,0773424 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01510124 0,0771806 ! striatum development GO:0021756 14 5 0,000 0,01510124 0,07701947 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01510124 0,07685901 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01510124 0,07669922 ! glial cell migration GO:0008347 10 5 0,000 0,01510124 0,07654009 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01510124 0,07638162 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01510124 0,07622381 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01510124 0,07606665 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01510124 0,07591013 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01510124 0,07575426 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01510124 0,07559903 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01510124 0,07544443 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01510124 0,07529046 ! neuroprotection GO:0043526 8 5 0,000 0,01510124 0,07513712 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01510124 0,0749844 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01510124 0,0748323 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01510124 0,07468082 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01510124 0,07452995 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01510124 0,07437969 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01510124 0,07423003 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01510124 0,07408097 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01510124 0,07393251 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01510124 0,07378465 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01510124 0,07363737 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,01510124 0,07349069 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01510124 0,07334458 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01510124 0,07319906 ! spindle assembly GO:0051225 6 5 0,000 0,01510124 0,07305411 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01510124 0,07290973 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01510124 0,07276593 ! protein palmitoylation GO:0018345 12 5 0,000 0,01510124 0,07262269 ! drug metabolic process GO:0017144 7 5 0,000 0,01510124 0,07248001 ! stem cell division GO:0017145 11 5 0,000 0,01510124 0,07233789 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01510124 0,07219633 ! organ regeneration GO:0031100 7 5 0,000 0,01510124 0,07205532 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01510124 0,07191486 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01510124 0,07177495 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,0153628 0,07287636 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,01583539 0,0749726 ! regulation of mitosis GO:0007088 112 63 1,000 0,01583539 0,07482759 GO:0051783|regulation of nuclear division, ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,01631417 0,07694115 ! ear development GO:0043583 114 66 1,000 0,01729012 0,08138685 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,01729012 0,08123033 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,01729012 0,08107442 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,01778722 0,08324555 GO:0035113|embryonic appendage morphogenesis, ! myeloid cell differentiation GO:0030099 126 67 1,000 0,01778722 0,08308638 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01809426 0,08435932 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01809426 0,08419863 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01809426 0,08403856 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01809426 0,08387909 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01809426 0,08372023 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01809426 0,08356197 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01809426 0,0834043 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01809426 0,08324723 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01809426 0,08309075 ! response to oxygen radical GO:0000305 11 6 0,000 0,01809426 0,08293486 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01809426 0,08277955 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01809426 0,08262483 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01809426 0,08247067 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01809426 0,0823171 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01809426 0,08216409 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01809426 0,08201165 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01809426 0,08185978 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01809426 0,08170847 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01809426 0,08155771 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01809426 0,08140752 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01809426 0,08125787 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01809426 0,08110877 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01809426 0,08096022 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01809426 0,08081221 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01809426 0,08066475 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01809426 0,08051782 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01809426 0,08037142 ! malate metabolic process GO:0006108 13 6 0,000 0,01809426 0,08022556 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01809426 0,08008022 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01809426 0,07993541 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01809426 0,07979112 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01809426 0,07964735 ! protein refolding GO:0042026 15 6 0,000 0,01809426 0,0795041 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01809426 0,07936137 ! opsonization GO:0008228 8 6 0,000 0,01809426 0,07921914 ! mating behavior GO:0007617 7 6 0,000 0,01809426 0,07907743 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01809426 0,07893622 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01809426 0,07879551 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01809426 0,07865531 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01809426 0,0785156 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01809426 0,07837639 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01809426 0,07823767 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01809426 0,07809944 ! toxin metabolic process GO:0009404 11 6 0,000 0,01809426 0,0779617 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01809426 0,07782444 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01809426 0,07768767 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01809426 0,07755137 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01809426 0,07741555 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01809426 0,07728021 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01809426 0,07714534 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01809426 0,07701094 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01809426 0,07687701 ! thymic T cell selection GO:0045061 16 6 0,000 0,01809426 0,07674354 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01809426 0,07661054 ! protein lipoylation GO:0009249 10 6 0,000 0,01809426 0,076478 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01809426 0,07634591 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01809426 0,07621428 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01809426 0,0760831 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01809426 0,07595237 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01809426 0,0758221 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01809426 0,07569226 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01809426 0,07556287 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01809426 0,07543393 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01809426 0,07530542 ! hyperosmotic response GO:0006972 10 6 0,000 0,01809426 0,07517735 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01809426 0,07504971 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01809426 0,07492251 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01809426 0,07479574 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01809426 0,07466939 ! urea metabolic process GO:0019627 7 6 0,000 0,01809426 0,07454348 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01809426 0,07441798 ! neutrophil activation GO:0042119 7 6 0,000 0,01809426 0,07429291 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01809426 0,07416826 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01809426 0,07404402 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01809426 0,0739202 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01809426 0,0737968 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01809426 0,0736738 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01809426 0,07355122 ! neuron apoptosis GO:0051402 15 6 0,000 0,01809426 0,07342904 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01809426 0,07330727 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01809426 0,0731859 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01809426 0,07306493 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01809426 0,07294436 ! carnitine transport GO:0015879 10 6 0,000 0,01809426 0,07282419 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01809426 0,07270441 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01809426 0,07258503 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01809426 0,07246604 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01809426 0,07234743 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01809426 0,07222922 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01809426 0,07211139 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01809426 0,07199394 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01809426 0,07187688 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01809426 0,0717602 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01809426 0,07164389 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01809426 0,07152796 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01809426 0,07141241 ! response to UV-C GO:0010225 14 6 0,000 0,01809426 0,07129723 ! astrocyte development GO:0014002 16 6 0,000 0,01809426 0,07118242 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01809426 0,07106798 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01809426 0,0709539 ! interaction with symbiont GO:0051702 14 6 0,000 0,01809426 0,07084019 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01809426 0,07072685 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01809426 0,07061387 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01809426 0,07050125 ! response to copper ion GO:0046688 10 6 0,000 0,01809426 0,07038898 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01809426 0,07027708 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01809426 0,07016553 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01809426 0,07005433 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01809426 0,06994348 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01809426 0,06983299 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01809426 0,06972284 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01809426 0,06961304 ! hair follicle maturation GO:0048820 8 6 0,000 0,01809426 0,06950359 ! Schwann cell development GO:0014044 15 6 0,000 0,01809426 0,06939448 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01809426 0,06928571 ! response to pheromone GO:0019236 6 6 0,000 0,01809426 0,06917728 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01809426 0,06906919 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01809426 0,06896144 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01809426 0,06885402 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01809426 0,06874694 ! subpallium development GO:0021544 15 6 0,000 0,01809426 0,06864019 ! neural tube patterning GO:0021532 8 6 0,000 0,01809426 0,06853377 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01809426 0,06842768 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01809426 0,06832192 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01809426 0,06821648 ! G2 phase GO:0051319 16 6 0,000 0,01809426 0,06811137 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01809426 0,06800659 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01809426 0,06790212 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01809426 0,06779798 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01809426 0,06769415 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01809426 0,06759064 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01809426 0,06748745 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01809426 0,06738458 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01809426 0,06728201 ! receptor internalization GO:0031623 11 6 0,000 0,01809426 0,06717976 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01809426 0,06707782 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01809426 0,06697618 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01809426 0,06687486 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01809426 0,06677384 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01809426 0,06667312 ! protein deubiquitination GO:0016579 16 6 0,000 0,01809426 0,06657271 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01809426 0,0664726 ! protein destabilization GO:0031648 9 6 0,000 0,01809426 0,0663728 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01809426 0,06627329 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01809426 0,06617407 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01809426 0,06607516 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01809426 0,06597654 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01809426 0,06587821 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01809426 0,06578018 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01809426 0,06568244 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01809426 0,06558499 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01809426 0,06548782 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01809426 0,06539095 ! neural plate development GO:0001840 9 6 0,000 0,01809426 0,06529436 ! catecholamine transport GO:0051937 9 6 0,000 0,01809426 0,06519806 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01809426 0,06510203 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01809426 0,0650063 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01809426 0,06491084 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01809426 0,06481566 ! maternal placenta development GO:0001893 12 6 0,000 0,01809426 0,06472076 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01809426 0,06462614 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01809426 0,0645318 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01809426 0,06443773 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01809426 0,06434393 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01809426 0,06425041 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01809426 0,06415716 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01809426 0,06406418 GO:0055081|anion homeostasis, ! extracellular matrix organization GO:0030198 146 68 1,000 0,01829034 0,06466468 ! detection of external stimulus GO:0009581 102 68 1,000 0,01829034 0,06457123 ! negative regulation of protein kinase activity GO:0006469 144 69 1,000 0,01879944 0,06627277 ! urogenital system development GO:0001655 149 69 1,000 0,01879944 0,06617728 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,01879944 0,06608206 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01879944 0,06598711 ! negative regulation of kinase activity GO:0033673 145 70 1,000 0,01931448 0,06769768 ! cell cycle checkpoint GO:0000075 145 71 1,000 0,01983543 0,06942401 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,01983543 0,0693247 ! appendage morphogenesis GO:0035107 150 72 1,000 0,02036224 0,07106423 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 151 73 1,000 0,02089488 0,0728191 GO:0060173|limb development, ! tRNA transcription GO:0009304 17 7 0,000 0,02107827 0,07335359 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02107827 0,07324925 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02107827 0,0731452 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02107827 0,07304145 ! regulation of helicase activity GO:0051095 16 7 0,000 0,02107827 0,07293799 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02107827 0,07283483 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02107827 0,07273195 ! sleep GO:0030431 16 7 0,000 0,02107827 0,07262937 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02107827 0,07252707 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02107827 0,07242507 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02107827 0,07232335 ! prostate gland development GO:0030850 14 7 0,000 0,02107827 0,07222191 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02107827 0,07212076 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02107827 0,07201989 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02107827 0,07191931 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02107827 0,071819 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02107827 0,07171897 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02107827 0,07161923 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02107827 0,07151975 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02107827 0,07142056 ! glycolipid transport GO:0046836 11 7 0,000 0,02107827 0,07132164 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02107827 0,07122299 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,02107827 0,07112462 ! neuron adhesion GO:0007158 14 7 0,000 0,02107827 0,07102651 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,02107827 0,07092868 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02107827 0,07083112 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02107827 0,07073382 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02107827 0,07063679 ! mRNA stabilization GO:0048255 18 7 0,000 0,02107827 0,07054003 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,02107827 0,07044353 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02107827 0,0703473 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02107827 0,07025133 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,02107827 0,07015562 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02107827 0,07006017 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02107827 0,06996498 ! lipoprotein transport GO:0042953 14 7 0,000 0,02107827 0,06987004 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02107827 0,06977537 ! rhythmic behavior GO:0007622 17 7 0,000 0,02107827 0,06968095 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02107827 0,06958679 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02107827 0,06949288 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02107827 0,06939922 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02107827 0,06930582 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02107827 0,06921267 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02107827 0,06911976 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02107827 0,06902711 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02107827 0,0689347 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02107827 0,06884254 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02107827 0,06875063 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02107827 0,06865896 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02107827 0,06856754 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02107827 0,06847636 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02107827 0,06838542 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02107827 0,06829473 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02107827 0,06820427 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02107827 0,06811405 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02107827 0,06802407 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02107827 0,06793433 ! adrenal gland development GO:0030325 17 7 0,000 0,02107827 0,06784483 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02107827 0,06775556 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02107827 0,06766652 ! ovulation GO:0030728 10 7 0,000 0,02107827 0,06757772 ! adenohypophysis development GO:0021984 11 7 0,000 0,02107827 0,06748915 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02107827 0,06740082 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02107827 0,06731271 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02107827 0,06722483 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02107827 0,06713719 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02107827 0,06704977 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02107827 0,06696258 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02107827 0,06687561 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02107827 0,06678888 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02107827 0,06670236 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02107827 0,06661607 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02107827 0,06653 ! galactose metabolic process GO:0006012 13 7 0,000 0,02107827 0,06644416 ! vesicle fusion GO:0006906 20 7 0,000 0,02107827 0,06635853 ! response to dietary excess GO:0002021 8 7 0,000 0,02107827 0,06627313 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02107827 0,06618795 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02107827 0,06610298 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02107827 0,06601823 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02107827 0,0659337 ! organ growth GO:0035265 15 7 0,000 0,02107827 0,06584939 ! nucleoside transport GO:0015858 11 7 0,000 0,02107827 0,06576529 ! nucleoside salvage GO:0043174 11 7 0,000 0,02107827 0,06568141 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02107827 0,06559774 ! male sex determination GO:0030238 15 7 0,000 0,02107827 0,06551428 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02107827 0,06543103 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02107827 0,065348 ! parturition GO:0007567 16 7 0,000 0,02107827 0,06526517 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02107827 0,06518256 ! rRNA modification GO:0000154 14 7 0,000 0,02107827 0,06510016 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02107827 0,06501796 ! spindle checkpoint GO:0031577 16 7 0,000 0,02107827 0,06493597 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02107827 0,06485419 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02107827 0,06477261 ! monocyte differentiation GO:0030224 16 7 0,000 0,02107827 0,06469123 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02107827 0,06461007 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02107827 0,0645291 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02107827 0,06444834 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02107827 0,06436778 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,02107827 0,06428742 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02107827 0,06420726 ! fibrinolysis GO:0042730 11 7 0,000 0,02107827 0,0641273 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02107827 0,06404754 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02107827 0,06396798 ! eating behavior GO:0042755 8 7 0,000 0,02107827 0,06388861 ! B cell lineage commitment GO:0002326 21 7 0,000 0,02107827 0,06380945 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02107827 0,06373047 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02107827 0,0636517 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02107827 0,06357311 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02107827 0,06349473 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02107827 0,06341653 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02107827 0,06333853 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02107827 0,06326072 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02107827 0,0631831 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02107827 0,06310567 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02107827 0,06302842 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02107827 0,06295137 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02107827 0,06287451 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02107827 0,06279783 ! histone ubiquitination GO:0016574 9 7 0,000 0,02107827 0,06272134 ! regulation of meiosis GO:0040020 12 7 0,000 0,02107827 0,06264504 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02107827 0,06256892 ! T cell lineage commitment GO:0002360 16 7 0,000 0,02107827 0,06249299 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02107827 0,06241724 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02107827 0,06234167 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02107827 0,06226629 ! transcription termination GO:0006353 14 7 0,000 0,02107827 0,06219109 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02107827 0,06211607 ! anaphase GO:0051322 18 7 0,000 0,02107827 0,06204123 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02107827 0,06196657 ! axonal fasciculation GO:0007413 19 7 0,000 0,02107827 0,06189209 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02107827 0,06181779 GO:0045839|negative regulation of mitosis, ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02107827 0,06174367 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02107827 0,06166973 ! diuresis GO:0030146 12 7 0,000 0,02107827 0,06159596 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02107827 0,06152237 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02107827 0,06144895 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02107827 0,06137571 ! antibiotic transport GO:0042891 9 7 0,000 0,02107827 0,06130265 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02107827 0,06122975 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02107827 0,06115703 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02107827 0,06108449 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02107827 0,06101211 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02107827 0,06093991 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02107827 0,06086788 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02107827 0,06079601 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02107827 0,06072432 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02107827 0,06065279 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02107827 0,06058144 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02107827 0,06051025 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02107827 0,06043923 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02107827 0,06036837 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02107827 0,06029768 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02107827 0,06022716 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02107827 0,0601568 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02107827 0,06008661 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02107827 0,06001658 ! muscle adaptation GO:0043500 13 7 0,000 0,02107827 0,05994671 ! retina homeostasis GO:0001895 12 7 0,000 0,02107827 0,059877 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02107827 0,05980746 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02107827 0,05973808 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02107827 0,05966886 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02107827 0,0595998 ! negative regulation of transferase activity GO:0051348 155 74 1,000 0,0214333 0,06053358 ! organelle localization GO:0051640 155 74 1,000 0,0214333 0,06046368 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,02197746 0,06192726 ! eye development GO:0001654 155 75 1,000 0,02197746 0,06185592 ! axon guidance GO:0007411 162 75 1,000 0,02197746 0,06178474 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,02252733 0,06325778 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,02252733 0,06318515 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,0240533 0,06738786 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,0240533 0,06731067 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,0240533 0,06723366 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,0240533 0,06715682 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,0240533 0,06708015 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,0240533 0,06700367 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,0240533 0,06692735 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,0240533 0,06685121 ! male meiosis GO:0007140 9 8 0,000 0,0240533 0,06677524 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,0240533 0,06669945 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,0240533 0,06662383 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,0240533 0,06654837 ! meiotic prophase I GO:0007128 14 8 0,000 0,0240533 0,06647309 ! response to zinc ion GO:0010043 12 8 0,000 0,0240533 0,06639798 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,0240533 0,06632304 ! oligopeptide transport GO:0006857 16 8 0,000 0,0240533 0,06624827 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,0240533 0,06617367 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,0240533 0,06609923 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,0240533 0,06602496 ! signal peptide processing GO:0006465 12 8 0,000 0,0240533 0,06595086 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,0240533 0,06587692 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,0240533 0,06580315 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,0240533 0,06572955 ! succinate metabolic process GO:0006105 17 8 0,000 0,0240533 0,06565611 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,0240533 0,06558283 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,0240533 0,06550972 ! estrogen metabolic process GO:0008210 17 8 0,000 0,0240533 0,06543676 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,0240533 0,06536398 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,0240533 0,06529135 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,0240533 0,06521888 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,0240533 0,06514658 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0240533 0,06507443 ! reflex GO:0060004 17 8 0,000 0,0240533 0,06500245 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,0240533 0,06493062 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,0240533 0,06485896 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,0240533 0,06478745 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,0240533 0,0647161 ! pigment granule organization GO:0048753 17 8 0,000 0,0240533 0,0646449 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,0240533 0,06457386 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,0240533 0,06450298 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,0240533 0,06443225 ! astrocyte differentiation GO:0048708 19 8 0,000 0,0240533 0,06436168 ! histidine catabolic process GO:0006548 10 8 0,000 0,0240533 0,06429126 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,0240533 0,064221 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,0240533 0,06415089 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,0240533 0,06408093 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,0240533 0,06401113 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,0240533 0,06394147 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,0240533 0,06387197 ! melanin metabolic process GO:0006582 17 8 0,000 0,0240533 0,06380262 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,0240533 0,06373342 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,0240533 0,06366437 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,0240533 0,06359547 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,0240533 0,06352672 ! macrophage activation GO:0042116 13 8 0,000 0,0240533 0,06345812 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,0240533 0,06338966 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,0240533 0,06332135 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,0240533 0,06325319 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,0240533 0,06318518 ! purine salvage GO:0043101 12 8 0,000 0,0240533 0,06311731 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,0240533 0,06304959 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0240533 0,06298201 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,0240533 0,06291458 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,0240533 0,06284729 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,0240533 0,06278014 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,0240533 0,06271314 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,0240533 0,06264628 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,0240533 0,06257957 ! response to UV-B GO:0010224 17 8 0,000 0,0240533 0,06251299 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,0240533 0,06244656 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,0240533 0,06238027 ! intermediate filament organization GO:0045109 12 8 0,000 0,0240533 0,06231412 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,0240533 0,06224811 ! cellular extravasation GO:0045123 13 8 0,000 0,0240533 0,06218224 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,0240533 0,06211651 ! response to antibiotic GO:0046677 11 8 0,000 0,0240533 0,06205091 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,0240533 0,06198546 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,0240533 0,06192014 ! DNA topological change GO:0006265 12 8 0,000 0,0240533 0,06185496 ! response to tropane GO:0014073 15 8 0,000 0,0240533 0,06178992 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,0240533 0,06172502 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,0240533 0,06166025 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,0240533 0,06159561 ! mast cell activation GO:0045576 14 8 0,000 0,0240533 0,06153111 ! multicellular organismal aging GO:0010259 20 8 0,000 0,0240533 0,06146675 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,0240533 0,06140252 ! gas homeostasis GO:0033483 14 8 0,000 0,0240533 0,06133843 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,0240533 0,06127447 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,0240533 0,06121064 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,0240533 0,06114695 ! nucleosome disassembly GO:0006337 14 8 0,000 0,0240533 0,06108338 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,0240533 0,06101995 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,0240533 0,06095665 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,0240533 0,06089349 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,0240533 0,06083045 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,0240533 0,06076754 ! intracellular lipid transport GO:0032365 16 8 0,000 0,0240533 0,06070477 ! response to tumor cell GO:0002347 16 8 0,000 0,0240533 0,06064212 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,0240533 0,0605796 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,0240533 0,06051721 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,0240533 0,06045495 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,0240533 0,06039282 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,0240533 0,06033082 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,0240533 0,06026894 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,0240533 0,06020719 ! hormone catabolic process GO:0042447 17 8 0,000 0,0240533 0,06014556 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,0240533 0,06008406 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,0240533 0,06002269 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,0240533 0,05996144 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,0240533 0,05990032 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,0240533 0,05983932 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,0240533 0,05977845 ! adult feeding behavior GO:0008343 10 8 0,000 0,0240533 0,0597177 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,0240533 0,05965707 ! ATP catabolic process GO:0006200 11 8 0,000 0,0240533 0,05959657 ! blastocyst growth GO:0001832 19 8 0,000 0,0240533 0,05953619 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,0240533 0,05947593 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,0240533 0,05941579 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,0240533 0,05935577 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,0240533 0,05929588 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,0240533 0,0592361 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,0240533 0,05917645 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,0240533 0,05911692 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,0240533 0,0590575 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,0240533 0,05899821 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,0240533 0,05893903 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,0240533 0,05887997 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,0240533 0,05882104 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,0240533 0,05876221 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,0240533 0,05870351 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,0240533 0,05864492 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,0240533 0,05858646 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,0240533 0,0585281 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,0240533 0,05846987 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,0240533 0,05841174 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,0240533 0,05835374 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,02421078 0,05867751 ! protein oligomerization GO:0051259 149 79 1,000 0,02421078 0,05861936 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,02478308 0,05994561 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,02478308 0,05988632 ! meiosis GO:0007126 143 81 1,000 0,02536089 0,061222 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,02536089 0,06116157 ! response to hypoxia GO:0001666 178 81 1,000 0,02536089 0,06110125 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,02594418 0,06244496 ! meiotic cell cycle GO:0051321 144 82 1,000 0,02594418 0,0623835 ! response to oxygen levels GO:0070482 183 83 1,000 0,02653291 0,06373637 ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,02653291 0,06367376 ! axon extension GO:0048675 16 9 0,000 0,02701937 0,06477755 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,02701937 0,06471404 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02701937 0,06465066 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02701937 0,0645874 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02701937 0,06452426 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02701937 0,06446125 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,02701937 0,06439836 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02701937 0,0643356 ! reproductive behavior GO:0019098 22 9 0,000 0,02701937 0,06427295 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02701937 0,06421043 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02701937 0,06414803 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02701937 0,06408575 ! UTP metabolic process GO:0046051 10 9 0,000 0,02701937 0,06402359 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02701937 0,06396155 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,02701937 0,06389963 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02701937 0,06383784 ! artery development GO:0060840 25 9 0,000 0,02701937 0,06377616 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02701937 0,0637146 ! regulation of glycolysis GO:0006110 20 9 0,000 0,02701937 0,06365316 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02701937 0,06359183 ! equilibrioception GO:0050957 20 9 0,000 0,02701937 0,06353063 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,02701937 0,06346954 ! chemosensory behavior GO:0007635 21 9 0,000 0,02701937 0,06340857 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02701937 0,06334772 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02701937 0,06328698 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02701937 0,06322636 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02701937 0,06316586 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02701937 0,06310547 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02701937 0,0630452 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02701937 0,06298504 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02701937 0,062925 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02701937 0,06286507 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02701937 0,06280525 ! protein targeting to ER GO:0045047 25 9 0,000 0,02701937 0,06274555 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02701937 0,06268597 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02701937 0,06262649 ! T cell selection GO:0045058 27 9 0,000 0,02701937 0,06256713 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 0,000 0,02701937 0,06250788 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02701937 0,06244874 ! glycine catabolic process GO:0006546 15 9 0,000 0,02701937 0,06238972 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02701937 0,0623308 ! endosome organization GO:0007032 20 9 0,000 0,02701937 0,062272 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02701937 0,06221331 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02701937 0,06215473 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02701937 0,06209626 ! mannose metabolic process GO:0006013 13 9 0,000 0,02701937 0,0620379 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02701937 0,06197965 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02701937 0,0619215 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02701937 0,06186347 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02701937 0,06180555 ! receptor clustering GO:0043113 20 9 0,000 0,02701937 0,06174773 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02701937 0,06169002 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02701937 0,06163242 ! retinol metabolic process GO:0042572 20 9 0,000 0,02701937 0,06157493 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02701937 0,06151754 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02701937 0,06146026 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02701937 0,06140309 ! macrophage differentiation GO:0030225 15 9 0,000 0,02701937 0,06134602 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02701937 0,06128906 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02701937 0,06123221 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02701937 0,06117546 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02701937 0,06111882 ! response to amine stimulus GO:0014075 13 9 0,000 0,02701937 0,06106228 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02701937 0,06100584 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02701937 0,06094951 ! erythrocyte development GO:0048821 17 9 0,000 0,02701937 0,06089329 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02701937 0,06083716 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02701937 0,06078114 ! renal water homeostasis GO:0003091 15 9 0,000 0,02701937 0,06072523 ! postreplication repair GO:0006301 25 9 0,000 0,02701937 0,06066941 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02701937 0,0606137 ! icosanoid secretion GO:0032309 15 9 0,000 0,02701937 0,06055809 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02701937 0,06050259 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02701937 0,06044718 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02701937 0,06039188 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02701937 0,06033667 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02701937 0,06028157 ! sterol catabolic process GO:0016127 14 9 0,000 0,02701937 0,06022657 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02701937 0,06017167 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02701937 0,06011687 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02701937 0,06006217 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,02701937 0,06000757 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02701937 0,05995306 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02701937 0,05989866 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02701937 0,05984435 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02701937 0,05979015 ! purine base metabolic process GO:0006144 25 9 0,000 0,02701937 0,05973604 ! pigment granule transport GO:0051904 17 9 0,000 0,02701937 0,05968203 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02701937 0,05962811 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02701937 0,0595743 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02701937 0,05952058 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02701937 0,05946696 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02701937 0,05941343 ! mitochondrion localization GO:0051646 18 9 0,000 0,02701937 0,05936 ! mitochondrion organization GO:0007005 159 87 1,000 0,02894141 0,06352548 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02997651 0,06573843 ! regulation of developmental growth GO:0048638 16 10 0,000 0,02997651 0,06567947 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,02997651 0,06562062 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02997651 0,06556187 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02997651 0,06550323 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02997651 0,06544469 ! associative learning GO:0008306 21 10 0,000 0,02997651 0,06538626 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,02997651 0,06532793 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02997651 0,06526971 ! phosphate transport GO:0006817 24 10 0,000 0,02997651 0,06521159 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02997651 0,06515357 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02997651 0,06509565 ! CTP metabolic process GO:0046036 11 10 0,000 0,02997651 0,06503784 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02997651 0,06498013 ! GTP metabolic process GO:0046039 11 10 0,000 0,02997651 0,06492253 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02997651 0,06486502 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02997651 0,06480762 ! social behavior GO:0035176 29 10 0,000 0,02997651 0,06475032 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02997651 0,06469312 GO:0048200|Golgi transport vesicle coating, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02997651 0,06463602 ! androgen metabolic process GO:0008209 17 10 0,000 0,02997651 0,06457902 ! phospholipid efflux GO:0033700 19 10 0,000 0,02997651 0,06452212 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02997651 0,06446533 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02997651 0,06440863 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02997651 0,06435203 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02997651 0,06429553 ! lung alveolus development GO:0048286 26 10 0,000 0,02997651 0,06423913 ! pathogenesis GO:0009405 17 10 0,000 0,02997651 0,06418283 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02997651 0,06412663 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02997651 0,06407053 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02997651 0,06401452 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02997651 0,06395861 ! endoderm development GO:0007492 18 10 0,000 0,02997651 0,0639028 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02997651 0,06384709 ! arginine catabolic process GO:0006527 17 10 0,000 0,02997651 0,06379147 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02997651 0,06373595 ! proline metabolic process GO:0006560 13 10 0,000 0,02997651 0,06368053 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02997651 0,06362521 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02997651 0,06356997 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02997651 0,06351484 ! V(D)J recombination GO:0033151 34 10 0,000 0,02997651 0,0634598 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02997651 0,06340486 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02997651 0,06335001 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02997651 0,06329526 ! B cell proliferation GO:0042100 19 10 0,000 0,02997651 0,0632406 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02997651 0,06318603 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02997651 0,06313156 ! multicellular organism growth GO:0035264 19 10 0,000 0,02997651 0,06307718 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02997651 0,0630229 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02997651 0,06296871 ! ruffle organization GO:0031529 17 10 0,000 0,02997651 0,06291461 ! epithelial cell development GO:0002064 21 10 0,000 0,02997651 0,06286061 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02997651 0,0628067 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02997651 0,06275288 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02997651 0,06269915 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02997651 0,06264552 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02997651 0,06259198 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02997651 0,06253852 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,02997651 0,06248516 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02997651 0,06243189 ! regulation of bone resorption GO:0045124 25 10 0,000 0,02997651 0,06237871 ! protein heterooligomerization GO:0051291 17 10 0,000 0,02997651 0,06232563 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02997651 0,06227263 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02997651 0,06221972 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02997651 0,0621669 ! segment specification GO:0007379 15 10 0,000 0,02997651 0,06211417 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02997651 0,06206153 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02997651 0,06200898 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02997651 0,06195652 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02997651 0,06190415 ! response to dsRNA GO:0043331 23 10 0,000 0,02997651 0,06185187 ! DNA ligation GO:0006266 18 10 0,000 0,02997651 0,06179967 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02997651 0,06174756 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02997651 0,06169554 ! melanosome localization GO:0032400 16 10 0,000 0,02997651 0,06164361 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02997651 0,06159177 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02997651 0,06154001 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02997651 0,06148834 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02997651 0,06143675 ! induction of an organ GO:0001759 17 10 0,000 0,02997651 0,06138526 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02997651 0,06133385 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02997651 0,06128252 ! protein sumoylation GO:0016925 17 10 0,000 0,02997651 0,06123128 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02997651 0,06118013 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02997651 0,06112906 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02997651 0,06107807 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02997651 0,06102718 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02997651 0,06097636 ! salivary gland development GO:0007431 28 10 0,000 0,02997651 0,06092563 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02997651 0,06087499 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02997651 0,06082443 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02997651 0,06077395 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02997651 0,06072356 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02997651 0,06067325 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02997651 0,06062302 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02997651 0,06057288 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02997651 0,06052282 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02997651 0,06047284 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02997651 0,06042295 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02997651 0,06037313 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,02997651 0,0603234 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,02997651 0,06027375 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02997651 0,06022419 ! blastocyst formation GO:0001825 18 10 0,000 0,02997651 0,0601747 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02997651 0,0601253 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02997651 0,06007597 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02997651 0,06002673 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02997651 0,05997757 ! response to nicotine GO:0035094 20 10 0,000 0,02997651 0,05992849 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02997651 0,05987949 ! response to unfolded protein GO:0006986 139 90 1,000 0,03080303 0,06148024 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,03080303 0,06143005 ! ossification GO:0001503 205 91 1,000 0,0314339 0,06263705 ! bone development GO:0060348 206 92 1,000 0,03206987 0,06385224 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,03206987 0,06380024 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03292474 0,06544764 ! respiratory burst GO:0045730 17 11 0,000 0,03292474 0,06539443 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03292474 0,0653413 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03292474 0,06528827 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03292474 0,06523532 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,03292474 0,06518245 ! synapsis GO:0007129 14 11 0,000 0,03292474 0,06512967 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03292474 0,06507698 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03292474 0,06502437 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,03292474 0,06497185 ! response to pain GO:0048265 27 11 0,000 0,03292474 0,06491941 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03292474 0,06486705 ! blood vessel remodeling GO:0001974 30 11 0,000 0,03292474 0,06481478 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,03292474 0,0647626 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,03292474 0,0647105 ! bone resorption GO:0045453 16 11 0,000 0,03292474 0,06465848 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03292474 0,06460654 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,03292474 0,06455469 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03292474 0,06450292 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03292474 0,06445124 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03292474 0,06439964 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03292474 0,06434812 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03292474 0,06429668 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03292474 0,06424532 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03292474 0,06419405 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,03292474 0,06414286 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03292474 0,06409175 ! UV protection GO:0009650 20 11 0,000 0,03292474 0,06404072 ! adult heart development GO:0007512 16 11 0,000 0,03292474 0,06398977 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03292474 0,06393891 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03292474 0,06388812 ! macroautophagy GO:0016236 19 11 0,000 0,03292474 0,06383742 ! temperature homeostasis GO:0001659 18 11 0,000 0,03292474 0,06378679 ! behavioral fear response GO:0001662 27 11 0,000 0,03292474 0,06373625 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03292474 0,06368578 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03292474 0,0636354 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03292474 0,0635851 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03292474 0,06353487 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03292474 0,06348472 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03292474 0,06343466 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03292474 0,06338467 ! regulation of organ growth GO:0046620 14 11 0,000 0,03292474 0,06333476 ! pigment granule localization GO:0051875 20 11 0,000 0,03292474 0,06328493 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03292474 0,06323518 ! vasoconstriction GO:0042310 20 11 0,000 0,03292474 0,0631855 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03292474 0,06313591 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03292474 0,06308639 ! embryonic axis specification GO:0000578 19 11 0,000 0,03292474 0,06303695 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03292474 0,06298759 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03292474 0,0629383 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03292474 0,06288909 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03292474 0,06283996 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03292474 0,0627909 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03292474 0,06274192 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03292474 0,06269302 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03292474 0,06264419 ! prophase GO:0051324 17 11 0,000 0,03292474 0,06259544 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03292474 0,06254677 ! nucleosome positioning GO:0016584 15 11 0,000 0,03292474 0,06249817 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03292474 0,06244965 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03292474 0,0624012 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03292474 0,06235283 ! apical protein localization GO:0045176 18 11 0,000 0,03292474 0,06230453 ! acid secretion GO:0046717 20 11 0,000 0,03292474 0,06225631 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03292474 0,06220816 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03292474 0,06216008 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,03292474 0,06211208 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03292474 0,06206416 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03292474 0,0620163 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03292474 0,06196853 ! cholesterol efflux GO:0033344 21 11 0,000 0,03292474 0,06192082 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03292474 0,06187319 ! oocyte development GO:0048599 20 11 0,000 0,03292474 0,06182563 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03292474 0,06177815 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03292474 0,06173073 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03292474 0,06168339 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03292474 0,06163613 ! activation of innate immune response GO:0002218 16 11 0,000 0,03292474 0,06158893 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03292474 0,06154181 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03292474 0,06149476 ! lysogeny GO:0030069 22 11 0,000 0,03292474 0,06144778 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03292474 0,06140087 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03292474 0,06135404 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03292474 0,06130728 ! regulation of embryonic development GO:0045995 35 11 0,000 0,03292474 0,06126058 ! nucleus localization GO:0051647 22 11 0,000 0,03292474 0,06121396 ! regulation of membrane potential GO:0042391 179 94 1,000 0,03335697 0,06197041 ! sex differentiation GO:0007548 171 96 1,000 0,03466405 0,06434976 ! response to protein stimulus GO:0051789 158 96 1,000 0,03466405 0,0643009 ! transcription initiation GO:0006352 171 97 1,000 0,035325 0,06547721 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,0358641 0,06642607 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,0358641 0,06637575 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,0358641 0,06632551 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,0358641 0,06627533 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,0358641 0,06622524 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,0358641 0,06617522 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,0358641 0,06612528 ! protein complex disassembly GO:0043241 28 12 0,000 0,0358641 0,06607541 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,0358641 0,06602562 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,0358641 0,0659759 ! hippocampus development GO:0021766 29 12 0,000 0,0358641 0,06592625 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,0358641 0,06587669 ! T cell proliferation GO:0042098 32 12 0,000 0,0358641 0,06582719 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,0358641 0,06577777 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,0358641 0,06572843 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,0358641 0,06567915 ! drug transport GO:0015893 16 12 0,000 0,0358641 0,06562996 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,0358641 0,06558083 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,0358641 0,06553178 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,0358641 0,0654828 ! polyamine metabolic process GO:0006595 18 12 0,000 0,0358641 0,0654339 ! focal adhesion formation GO:0048041 37 12 0,000 0,0358641 0,06538507 ! mitotic spindle organization GO:0007052 23 12 0,000 0,0358641 0,06533631 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,0358641 0,06528762 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,0358641 0,06523901 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,0358641 0,06519047 ! lipid digestion GO:0044241 21 12 0,000 0,0358641 0,065142 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,0358641 0,0650936 ! entry into host cell GO:0030260 34 12 0,000 0,0358641 0,06504528 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0358641 0,06499703 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,0358641 0,06494885 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,0358641 0,06490073 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,0358641 0,0648527 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,0358641 0,06480473 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,0358641 0,06475683 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,0358641 0,064709 ! snRNA metabolic process GO:0016073 30 12 0,000 0,0358641 0,06466125 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,0358641 0,06461356 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,0358641 0,06456595 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,0358641 0,0645184 ! fucose catabolic process GO:0019317 25 12 0,000 0,0358641 0,06447093 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,0358641 0,06442352 ! histone acetylation GO:0016573 27 12 0,000 0,0358641 0,06437619 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,0358641 0,06432892 ! autonomic nervous system development GO:0048483 24 12 0,000 0,0358641 0,06428173 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,0358641 0,0642346 ! zymogen activation GO:0031638 18 12 0,000 0,0358641 0,06418754 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,0358641 0,06414055 ! T cell homeostasis GO:0043029 28 12 0,000 0,0358641 0,06409363 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,0358641 0,06404678 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,0358641 0,06399999 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,0358641 0,06395328 ! oocyte differentiation GO:0009994 21 12 0,000 0,0358641 0,06390663 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,0358641 0,06386005 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,0358641 0,06381354 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,0358641 0,0637671 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,0358641 0,06372072 ! defense response to fungus GO:0050832 15 12 0,000 0,0358641 0,06367441 ! developmental induction GO:0031128 22 12 0,000 0,0358641 0,06362817 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,0358641 0,063582 ! lamellipodium assembly GO:0030032 24 12 0,000 0,0358641 0,06353589 ! response to cold GO:0009409 17 12 0,000 0,0358641 0,06348985 ! establishment of cell polarity GO:0030010 21 12 0,000 0,0358641 0,06344388 ! regulation of synapse organization GO:0050807 18 12 0,000 0,0358641 0,06339797 ! localization within membrane GO:0051668 26 12 0,000 0,0358641 0,06335213 ! interphase of mitotic cell cycle GO:0051329 224 98 1,000 0,03599083 0,06353005 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,03733701 0,06585871 GO:0060538|skeletal muscle organ development, ! mRNA transport GO:0051028 185 100 1,000 0,03733701 0,0658112 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,0387946 0,06833108 ! cGMP metabolic process GO:0046068 18 13 0,000 0,0387946 0,06828185 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,0387946 0,0682327 ! regulation of chemokine production GO:0032642 18 13 0,000 0,0387946 0,06818361 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,0387946 0,06813459 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,0387946 0,06808564 ! peroxisomal transport GO:0043574 28 13 0,000 0,0387946 0,06803677 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,0387946 0,06798796 ! cartilage condensation GO:0001502 22 13 0,000 0,0387946 0,06793922 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,0387946 0,06789055 ! organelle fusion GO:0048284 36 13 0,000 0,0387946 0,06784196 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,0387946 0,06779343 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,0387946 0,06774497 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,0387946 0,06769658 ! endocrine pancreas development GO:0031018 25 13 0,000 0,0387946 0,06764826 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,0387946 0,06760001 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,0387946 0,06755183 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,0387946 0,06750371 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,0387946 0,06745567 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,0387946 0,06740769 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,0387946 0,06735978 ! methionine metabolic process GO:0006555 31 13 0,000 0,0387946 0,06731194 ! plasma membrane organization GO:0007009 27 13 0,000 0,0387946 0,06726417 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,0387946 0,06721646 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,0387946 0,06716883 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,0387946 0,06712126 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,0387946 0,06707375 ! cytokine metabolic process GO:0042107 24 13 0,000 0,0387946 0,06702632 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,0387946 0,06697895 ! exocrine system development GO:0035272 34 13 0,000 0,0387946 0,06693165 ! asymmetric protein localization GO:0008105 24 13 0,000 0,0387946 0,06688441 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,0387946 0,06683725 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,0387946 0,06679014 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,0387946 0,06674311 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,0387946 0,06669614 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,0387946 0,06664924 ! protein homotetramerization GO:0051289 24 13 0,000 0,0387946 0,0666024 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,0387946 0,06655563 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,0387946 0,06650892 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,0387946 0,06646228 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,0387946 0,06641571 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,0387946 0,0663692 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,0387946 0,06632275 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,0387946 0,06627637 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,0387946 0,06623006 ! histone methylation GO:0016571 29 13 0,000 0,0387946 0,06618381 ! chromatin silencing GO:0006342 29 13 0,000 0,0387946 0,06613762 ! gland morphogenesis GO:0022612 31 13 0,000 0,0387946 0,0660915 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,0387946 0,06604545 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,0387946 0,06599945 ! regulation of epidermis development GO:0045682 19 13 0,000 0,0387946 0,06595352 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,0387946 0,06590766 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,0387946 0,06586186 ! spleen development GO:0048536 24 13 0,000 0,0387946 0,06581612 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,0387946 0,06577045 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,0387946 0,06572484 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,0387946 0,06567929 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,0387946 0,0656338 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,0387946 0,06558838 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,0387946 0,06554302 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,0387946 0,06549773 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,0387946 0,0654525 ! insulin secretion GO:0030073 24 13 0,000 0,0387946 0,06540733 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,0387946 0,06536222 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,0387946 0,06531717 ! acrosome reaction GO:0007340 19 13 0,000 0,0387946 0,06527219 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,0387946 0,06522726 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,0387946 0,0651824 ! rRNA transcription GO:0009303 28 14 0,000 0,04171628 0,07004321 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04171628 0,06999511 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,04171628 0,06994707 ! water transport GO:0006833 21 14 0,000 0,04171628 0,06989909 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04171628 0,06985118 ! non-recombinational repair GO:0000726 29 14 0,000 0,04171628 0,06980334 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04171628 0,06975556 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04171628 0,06970785 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04171628 0,0696602 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04171628 0,06961262 ! lipid localization GO:0010876 32 14 0,000 0,04171628 0,0695651 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04171628 0,06951765 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,04171628 0,06947026 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04171628 0,06942294 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04171628 0,06937568 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04171628 0,06932849 ! arginine metabolic process GO:0006525 21 14 0,000 0,04171628 0,06928136 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04171628 0,06923429 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,04171628 0,06918729 ! regulation of heart rate GO:0002027 25 14 0,000 0,04171628 0,06914035 ! fear response GO:0042596 34 14 0,000 0,04171628 0,06909348 ! organic alcohol transport GO:0015850 29 14 0,000 0,04171628 0,06904666 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04171628 0,06899992 ! embryo implantation GO:0007566 30 14 0,000 0,04171628 0,06895323 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04171628 0,06890661 ! bone mineralization GO:0030282 18 14 0,000 0,04171628 0,06886005 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04171628 0,06881356 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,04171628 0,06876712 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04171628 0,06872075 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04171628 0,06867444 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04171628 0,0686282 ! regulation of cellular pH GO:0030641 27 14 0,000 0,04171628 0,06858202 ! ribosome assembly GO:0042255 18 14 0,000 0,04171628 0,0685359 ! cerebellum development GO:0021549 23 14 0,000 0,04171628 0,06848984 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04171628 0,06844384 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04171628 0,0683979 ! response to gamma radiation GO:0010332 30 14 0,000 0,04171628 0,06835203 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04171628 0,06830622 ! NADP metabolic process GO:0006739 24 14 0,000 0,04171628 0,06826047 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,04171628 0,06821478 ! oxygen transport GO:0015671 22 14 0,000 0,04171628 0,06816915 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04171628 0,06812358 ! regulation of RNA stability GO:0043487 33 14 0,000 0,04171628 0,06807807 ! regulation of axon extension GO:0030516 43 14 0,000 0,04171628 0,06803263 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04171628 0,06798724 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04171628 0,06794192 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,04462916 0,0726376 ! lactation GO:0007595 30 15 0,000 0,04462916 0,07258924 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,04462916 0,07254095 ! reproductive cellular process GO:0048610 22 15 0,000 0,04462916 0,07249271 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,04462916 0,07244455 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,04462916 0,07239644 ! superoxide anion generation GO:0042554 22 15 0,000 0,04462916 0,0723484 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,04462916 0,07230043 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,04462916 0,07225251 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,04462916 0,07220466 ! copper ion transport GO:0006825 22 15 0,000 0,04462916 0,07215688 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,04462916 0,07210916 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,04462916 0,0720615 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,04462916 0,0720139 ! sulfate transport GO:0008272 27 15 0,000 0,04462916 0,07196637 ! response to cAMP GO:0051591 25 15 0,000 0,04462916 0,07191889 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,04462916 0,07187149 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,04462916 0,07182414 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,04462916 0,07177686 ! response to hexose stimulus GO:0009746 25 15 0,000 0,04462916 0,07172963 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,04462916 0,07168247 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,04462916 0,07163538 ! vesicle coating GO:0006901 38 15 0,000 0,04462916 0,07158834 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,04462916 0,07154137 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,04462916 0,07149445 ! regulation of exocytosis GO:0017157 26 15 0,000 0,04462916 0,0714476 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,04462916 0,07140081 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,04462916 0,07135409 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,04462916 0,07130742 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,04462916 0,07126081 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,04462916 0,07121427 ! regulation of vasodilation GO:0042312 27 15 0,000 0,04462916 0,07116778 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,04462916 0,07112136 ! histone deacetylation GO:0016575 24 15 0,000 0,04462916 0,071075 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,04462916 0,07102869 ! water homeostasis GO:0030104 28 15 0,000 0,04462916 0,07098245 ! cofactor transport GO:0051181 30 15 0,000 0,04462916 0,07093627 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,04462916 0,07089015 ! muscle maintenance GO:0046716 26 15 0,000 0,04462916 0,07084408 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,04462916 0,07079808 ! intestinal absorption GO:0050892 31 15 0,000 0,04462916 0,07075214 ! dopamine metabolic process GO:0042417 35 15 0,000 0,04462916 0,07070625 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,04462916 0,07066043 ! heme biosynthetic process GO:0006783 33 15 0,000 0,04462916 0,07061467 ! cell killing GO:0001906 32 15 0,000 0,04462916 0,07056896 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,04462916 0,07052331 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,04462916 0,07047773 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,04462916 0,0704322 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,04462916 0,07038673 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,04462916 0,07034132 ! actin filament polymerization GO:0030041 27 15 0,000 0,04462916 0,07029597 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,04462916 0,07025067 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,04753327 0,07477384 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,04753327 0,07472573 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04753327 0,07467767 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04753327 0,07462968 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04753327 0,07458175 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,04753327 0,07453388 ! bone remodeling GO:0046849 28 16 0,000 0,04753327 0,07448607 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,04753327 0,07443832 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04753327 0,07439063 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04753327 0,07434301 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04753327 0,07429544 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04753327 0,07424794 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04753327 0,0742005 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,04753327 0,07415312 ! startle response GO:0001964 28 16 0,000 0,04753327 0,07410579 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04753327 0,07405853 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04753327 0,07401133 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04753327 0,07396419 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04753327 0,07391711 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04753327 0,07387009 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04753327 0,07382313 ! pituitary gland development GO:0021983 30 16 0,000 0,04753327 0,07377623 ! response to osmotic stress GO:0006970 27 16 0,000 0,04753327 0,07372938 ! lysosomal transport GO:0007041 31 16 0,000 0,04753327 0,0736826 ! fructose metabolic process GO:0006000 25 16 0,000 0,04753327 0,07363588 ! L-amino acid transport GO:0015807 33 16 0,000 0,04753327 0,07358921 ! stem cell development GO:0048864 46 16 0,000 0,04753327 0,07354261 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04753327 0,07349606 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04753327 0,07344958 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04753327 0,07340315 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04753327 0,07335678 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04753327 0,07331047 ! axon cargo transport GO:0008088 46 16 0,000 0,04753327 0,07326421 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04753327 0,07321802 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,04753327 0,07317188 ! DNA replication initiation GO:0006270 28 16 0,000 0,04753327 0,07312581 ! neuron recognition GO:0008038 40 16 0,000 0,04753327 0,07307979 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04753327 0,07303382 ! tissue regeneration GO:0042246 27 16 0,000 0,04753327 0,07298792 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04753327 0,07294207 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04753327 0,07289628 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,04753327 0,07285055 ! biomineral formation GO:0031214 22 16 0,000 0,04753327 0,07280488 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04753327 0,07275926 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04753327 0,0727137 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04753327 0,0726682 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04753327 0,07262275 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04753327 0,07257736 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04753327 0,07253203 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,04753327 0,07248675 ! peptide hormone processing GO:0016486 27 16 0,000 0,04753327 0,07244153 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,05042863 0,0768062 ! metencephalon development GO:0022037 32 17 0,000 0,05042863 0,07675835 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,05042863 0,07671055 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,05042863 0,07666282 ! signal complex assembly GO:0007172 47 17 0,000 0,05042863 0,07661514 ! filopodium assembly GO:0046847 42 17 0,000 0,05042863 0,07656752 ! endothelial cell migration GO:0043542 31 17 0,000 0,05042863 0,07651997 ! gene silencing by RNA GO:0031047 38 17 0,000 0,05042863 0,07647247 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,05042863 0,07642503 ! glial cell development GO:0021782 28 17 0,000 0,05042863 0,07637765 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,05042863 0,07633033 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,05042863 0,07628306 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,05042863 0,07623586 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,05042863 0,07618871 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,05042863 0,07614162 ! myoblast differentiation GO:0045445 50 17 0,000 0,05042863 0,07609459 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,05042863 0,07604762 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,05042863 0,07600071 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,05042863 0,07595385 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,05042863 0,07590705 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,05042863 0,07586031 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,05042863 0,07581363 ! membrane budding GO:0006900 42 17 0,000 0,05042863 0,075767 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,05042863 0,07572043 ! regulation of protein binding GO:0043393 33 17 0,000 0,05042863 0,07567392 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,05042863 0,07562747 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,05042863 0,07558107 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,05042863 0,07553473 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,05042863 0,07548845 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,05042863 0,07544222 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,05042863 0,07539605 ! steroid catabolic process GO:0006706 34 17 0,000 0,05042863 0,07534994 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,05042863 0,07530388 ! gas transport GO:0015669 26 17 0,000 0,05042863 0,07525788 ! organic cation transport GO:0015695 32 17 0,000 0,05042863 0,07521193 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,05042863 0,07516604 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,05042863 0,07512021 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,05042863 0,07507443 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,05331527 0,07932352 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,05331527 0,07927524 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,05331527 0,07922701 ! limbic system development GO:0021761 40 18 0,000 0,05331527 0,07917885 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,05331527 0,07913075 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,05331527 0,0790827 ! adult walking behavior GO:0007628 36 18 0,000 0,05331527 0,07903472 ! heart looping GO:0001947 34 18 0,000 0,05331527 0,07898679 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,05331527 0,07893892 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,05331527 0,0788911 ! centrosome cycle GO:0007098 26 18 0,000 0,05331527 0,07884335 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,05331527 0,07879565 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,05331527 0,07874801 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,05331527 0,07870043 ! glycine metabolic process GO:0006544 30 18 0,000 0,05331527 0,07865291 ! glutamine metabolic process GO:0006541 29 18 0,000 0,05331527 0,07860544 ! response to retinoic acid GO:0032526 31 18 0,000 0,05331527 0,07855803 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,05331527 0,07851068 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 0,000 0,05331527 0,07846338 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,05331527 0,07841614 ! DNA integration GO:0015074 32 18 0,000 0,05331527 0,07836896 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,05331527 0,07832184 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,05331527 0,07827477 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,05331527 0,07822776 ! neural crest cell migration GO:0001755 41 18 0,000 0,05331527 0,0781808 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,05331527 0,0781339 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,05331527 0,07808706 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,05331527 0,07804027 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,05331527 0,07799354 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,05331527 0,07794687 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,05331527 0,07790025 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,05331527 0,07785368 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,05331527 0,07780718 ! detection of bacterium GO:0016045 22 18 0,000 0,05331527 0,07776072 ! defense response to virus GO:0051607 43 18 0,000 0,05331527 0,07771433 ! microspike assembly GO:0030035 46 18 0,000 0,05331527 0,07766799 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,05331527 0,0776217 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,05331527 0,07757547 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,05619322 0,08171431 ! positive regulation of translation GO:0045727 31 19 0,000 0,05619322 0,0816657 ! negative regulation of defense response GO:0031348 27 19 0,000 0,05619322 0,08161714 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,05619322 0,08156865 ! neuron maturation GO:0042551 46 19 0,000 0,05619322 0,08152021 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,05619322 0,08147183 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,05619322 0,08142351 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,05619322 0,08137524 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,05619322 0,08132704 ! inositol metabolic process GO:0006020 33 19 0,000 0,05619322 0,08127889 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,05619322 0,08123079 ! memory GO:0007613 34 19 0,000 0,05619322 0,08118275 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,05619322 0,08113477 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,05619322 0,08108685 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,05619322 0,08103898 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,05619322 0,08099117 ! cerebral cortex development GO:0021987 40 19 0,000 0,05619322 0,08094342 ! response to vitamin A GO:0033189 32 19 0,000 0,05619322 0,08089572 ! heme metabolic process GO:0042168 40 19 0,000 0,05619322 0,08084808 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,05619322 0,08080049 ! response to fungus GO:0009620 26 19 0,000 0,05619322 0,08075296 ! peptide cross-linking GO:0018149 39 19 0,000 0,05619322 0,08070549 ! protein export from nucleus GO:0006611 40 19 0,000 0,05619322 0,08065807 ! heart process GO:0003015 32 19 0,000 0,05619322 0,08061071 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,05619322 0,0805634 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,05619322 0,08051615 ! visual learning GO:0008542 38 19 0,000 0,05619322 0,08046895 ! cellular pigmentation GO:0033059 37 19 0,000 0,05619322 0,08042181 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,05619322 0,08037473 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,05619322 0,0803277 ! vitamin transport GO:0051180 31 19 0,000 0,05619322 0,08028072 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,05619322 0,0802338 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,05619322 0,08018694 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,05619322 0,08014013 ! cilium assembly GO:0042384 38 19 0,000 0,05619322 0,08009337 ! peptide hormone secretion GO:0030072 32 19 0,000 0,05619322 0,08004667 ! protein secretion GO:0009306 45 20 0,000 0,0590625 0,0840849 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,0590625 0,08403593 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,0590625 0,08398701 ! positive regulation of ossification GO:0045778 50 20 0,000 0,0590625 0,08393815 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,0590625 0,08388935 ! skin development GO:0043588 42 20 0,000 0,0590625 0,08384061 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,0590625 0,08379192 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,0590625 0,08374329 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,0590625 0,08369471 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,0590625 0,08364619 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,0590625 0,08359773 ! response to vitamin GO:0033273 36 20 0,000 0,0590625 0,08354933 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,0590625 0,08350098 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,0590625 0,08345268 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,0590625 0,08340444 ! bile acid metabolic process GO:0008206 34 20 0,000 0,0590625 0,08335626 ! retinoid metabolic process GO:0001523 34 20 0,000 0,0590625 0,08330813 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,0590625 0,08326006 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,0590625 0,08321204 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,0590625 0,08316408 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,0590625 0,08311618 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,0590625 0,08306833 ! actin filament bundle formation GO:0051017 47 20 0,000 0,0590625 0,08302053 ! body fluid secretion GO:0007589 33 20 0,000 0,0590625 0,08297279 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,0590625 0,08292511 ! peptide secretion GO:0002790 38 20 0,000 0,0590625 0,08287748 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,0590625 0,0828299 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,0590625 0,08278238 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,0590625 0,08273491 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,0590625 0,0826875 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,0590625 0,08264014 ! cell-cell junction organization GO:0045216 43 20 0,000 0,0590625 0,08259284 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,0590625 0,08254559 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,0590625 0,08249839 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,0590625 0,08245125 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,0590625 0,08240416 ! regulation of glucose import GO:0046324 30 20 0,000 0,0590625 0,08235713 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,0590625 0,08231015 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,0590625 0,08226322 ! negative regulation of translation GO:0017148 32 20 0,000 0,0590625 0,08221634 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,0590625 0,08216952 ! regulation of cell killing GO:0031341 46 21 0,000 0,06192314 0,0861003 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,06192314 0,08605132 ! hormone secretion GO:0046879 39 21 0,000 0,06192314 0,0860024 ! lipid phosphorylation GO:0046834 43 21 0,000 0,06192314 0,08595353 ! cAMP metabolic process GO:0046058 41 21 0,000 0,06192314 0,08590472 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,06192314 0,08585597 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,06192314 0,08580727 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,06192314 0,08575863 ! ovarian follicle development GO:0001541 39 21 0,000 0,06192314 0,08571004 ! smooth muscle contraction GO:0006939 48 21 0,000 0,06192314 0,08566151 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 0,000 0,06192314 0,08561303 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,06192314 0,0855646 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,06192314 0,08551624 ! plasma membrane fusion GO:0045026 33 21 0,000 0,06192314 0,08546792 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,06192314 0,08541966 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,06192314 0,08537146 ! sensory perception of pain GO:0019233 33 21 0,000 0,06192314 0,08532331 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,06192314 0,08527521 ! diencephalon development GO:0021536 36 21 0,000 0,06192314 0,08522717 ! collagen fibril organization GO:0030199 62 21 0,000 0,06192314 0,08517918 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,06192314 0,08513124 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,06192314 0,08508336 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,06192314 0,08503554 ! collagen catabolic process GO:0030574 29 21 0,000 0,06192314 0,08498776 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,06192314 0,08494005 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,06192314 0,08489238 ! actin filament-based movement GO:0030048 47 21 0,000 0,06192314 0,08484477 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,06192314 0,08479721 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,06477516 0,08865306 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,06477516 0,08860342 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,06477516 0,08855384 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,06477516 0,08850431 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,06477516 0,08845484 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,06477516 0,08840542 ! microtubule-based transport GO:0010970 59 22 0,000 0,06477516 0,08835606 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,06477516 0,08830675 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,06477516 0,0882575 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,06477516 0,08820831 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,06477516 0,08815917 ! cellular response to starvation GO:0009267 37 22 0,000 0,06477516 0,08811008 ! vacuolar transport GO:0007034 41 22 0,000 0,06477516 0,08806105 ! central nervous system neuron development GO:0021954 47 22 0,000 0,06477516 0,08801207 ! fucose metabolic process GO:0006004 44 22 0,000 0,06477516 0,08796315 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,06477516 0,08791428 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,06477516 0,08786547 ! cell aging GO:0007569 48 22 0,000 0,06477516 0,08781671 ! stem cell differentiation GO:0048863 57 22 0,000 0,06477516 0,087768 ! cytolysis GO:0019835 27 22 0,000 0,06477516 0,08771935 ! renal system process GO:0003014 42 22 0,000 0,06477516 0,08767075 ! vasodilation GO:0042311 40 22 0,000 0,06477516 0,08762221 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,06477516 0,08757372 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,06477516 0,08752528 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,06477516 0,0874769 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,06477516 0,08742857 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,06477516 0,08738029 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,06477516 0,08733207 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,06477516 0,0872839 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,06477516 0,08723578 ! sarcomere organization GO:0045214 32 22 0,000 0,06477516 0,08718772 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,06477516 0,08713971 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,06477516 0,08709175 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,06477516 0,08704384 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,06477516 0,08699599 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,06477516 0,08694819 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,06477516 0,08690044 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,06477516 0,08685275 ! protein stabilization GO:0050821 41 22 0,000 0,06477516 0,0868051 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,06761858 0,0905659 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,06761858 0,09051627 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,06761858 0,0904667 ! gluconeogenesis GO:0006094 38 23 0,000 0,06761858 0,09041719 ! glycerol metabolic process GO:0006071 40 23 0,000 0,06761858 0,09036773 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,06761858 0,09031832 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,06761858 0,09026896 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,06761858 0,09021966 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,06761858 0,09017042 ! regeneration GO:0031099 42 23 0,000 0,06761858 0,09012122 ! axis specification GO:0009798 43 23 0,000 0,06761858 0,09007208 ! visual behavior GO:0007632 46 23 0,000 0,06761858 0,090023 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,06761858 0,08997397 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,06761858 0,08992499 ! response to ethanol GO:0045471 47 23 0,000 0,06761858 0,08987606 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,06761858 0,08982719 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,06761858 0,08977837 ! peroxisome organization GO:0007031 43 23 0,000 0,06761858 0,0897296 ! lysosome organization GO:0007040 47 23 0,000 0,06761858 0,08968089 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,06761858 0,08963223 ! vesicle targeting GO:0006903 49 23 0,000 0,06761858 0,08958362 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,06761858 0,08953507 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,06761858 0,08948657 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,06761858 0,08943812 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,06761858 0,08938972 ! DNA modification GO:0006304 36 23 0,000 0,06761858 0,08934137 ! fatty acid transport GO:0015908 47 23 0,000 0,06761858 0,08929308 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,06761858 0,08924484 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,06761858 0,08919665 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,06761858 0,08914852 ! hormone transport GO:0009914 41 23 0,000 0,06761858 0,08910043 ! cell-cell recognition GO:0009988 28 23 0,000 0,06761858 0,0890524 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,06761858 0,08900442 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,06761858 0,08895649 GO:0006099|tricarboxylic acid cycle, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,07045345 0,09263605 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,07045345 0,09258621 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,07045345 0,09253644 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,07045345 0,09248671 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,07045345 0,09243704 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,07045345 0,09238743 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,07045345 0,09233786 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,07045345 0,09228835 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,07045345 0,09223889 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,07045345 0,09218949 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,07045345 0,09214014 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,07045345 0,09209084 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,07045345 0,09204159 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,07045345 0,0919924 ! sex determination GO:0007530 48 24 0,000 0,07045345 0,09194326 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,07045345 0,09189417 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,07045345 0,09184513 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,07045345 0,09179615 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,07045345 0,09174721 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,07045345 0,09169833 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,07045345 0,09164951 ! membrane depolarization GO:0051899 45 24 0,000 0,07045345 0,09160073 ! pallium development GO:0021543 56 24 0,000 0,07045345 0,09155201 ! oogenesis GO:0048477 44 24 0,000 0,07045345 0,09150334 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,07045345 0,09145471 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,07045345 0,09140615 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,07045345 0,09135763 ! platelet activation GO:0030168 41 24 0,000 0,07045345 0,09130916 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,07045345 0,09126075 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,07045345 0,09121239 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,07045345 0,09116408 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,07045345 0,09111581 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,07045345 0,09106761 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,07045345 0,09101945 ! regulation of amine transport GO:0051952 41 24 0,000 0,07045345 0,09097134 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,07045345 0,09092328 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,07327977 0,09452085 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,07327977 0,09447097 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,07327977 0,09442114 ! leukocyte adhesion GO:0007159 55 25 0,000 0,07327977 0,09437137 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,07327977 0,09432165 ! phototransduction GO:0007602 37 25 0,000 0,07327977 0,09427198 ! keratinization GO:0031424 37 25 0,000 0,07327977 0,09422236 ! vasculogenesis GO:0001570 49 25 0,000 0,07327977 0,09417279 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,07327977 0,09412328 ! vacuole organization GO:0007033 49 25 0,000 0,07327977 0,09407382 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,07327977 0,09402441 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,07327977 0,09397506 ! receptor metabolic process GO:0043112 53 25 0,000 0,07327977 0,09392575 ! chromosome condensation GO:0030261 48 25 0,000 0,07327977 0,0938765 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,07327977 0,0938273 ! regulation of behavior GO:0050795 48 25 0,000 0,07327977 0,09377815 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,07327977 0,09372905 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,07327977 0,09368 ! immunoglobulin production GO:0002377 62 25 0,000 0,07327977 0,09363101 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,07327977 0,09358206 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,07327977 0,09353317 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,07327977 0,09348433 ! protein tetramerization GO:0051262 57 25 0,000 0,07327977 0,09343553 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,07609758 0,09697777 ! initiation of viral infection GO:0019059 60 26 0,000 0,07609758 0,09692721 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,07609758 0,0968767 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,07609758 0,09682625 ! molting cycle process GO:0022404 52 26 0,000 0,07609758 0,09677584 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,07609758 0,09672549 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,07609758 0,09667519 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,07609758 0,09662494 GO:0051297|centrosome organization, ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,07609758 0,09657475 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,07609758 0,09652461 ! digestive system process GO:0022600 49 26 0,000 0,07609758 0,09647452 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,07609758 0,09642448 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,07609758 0,09637449 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,07609758 0,09632456 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,07609758 0,09627467 ! neural crest cell development GO:0014032 59 26 0,000 0,07609758 0,09622484 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,07609758 0,09617506 ! negative regulation of cell development GO:0010721 83 26 0,000 0,07609758 0,09612533 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,07609758 0,09607565 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,07609758 0,09602603 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,07609758 0,09597645 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,07609758 0,09592693 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,07609758 0,09587746 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,07609758 0,09582804 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,07609758 0,09577867 ! blastocyst development GO:0001824 50 26 0,000 0,07609758 0,09572935 ! telomere organization GO:0032200 46 26 0,000 0,07609758 0,09568008 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,07609758 0,09563086 ! neural tube closure GO:0001843 58 26 0,000 0,07609758 0,09558169 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,07609758 0,09553258 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,07609758 0,09548351 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,07609758 0,09543449 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,0789069 0,09890691 ! embryonic pattern specification GO:0009880 49 27 0,000 0,0789069 0,09885619 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,0789069 0,09880552 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,0789069 0,0987549 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,0789069 0,09870433 ! iron ion transport GO:0006826 65 27 0,000 0,0789069 0,09865382 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,0789069 0,09860336 ! superoxide metabolic process GO:0006801 41 27 0,000 0,0789069 0,09855295 ! tube lumen formation GO:0035148 59 27 0,000 0,0789069 0,09850259 ! insulin receptor signaling pathway GO:0008286 66 27 0,000 0,0789069 0,09845228 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,0789069 0,09840202 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,0789069 0,09835182 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,0789069 0,09830166 ! response to starvation GO:0042594 47 27 0,000 0,0789069 0,09825156 ! response to toxin GO:0009636 49 27 0,000 0,0789069 0,09820151 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,0789069 0,09815151 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,0789069 0,09810156 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,0789069 0,09805166 ! leukocyte proliferation GO:0070661 59 27 0,000 0,0789069 0,09800181 GO:0032943|mononuclear cell proliferation, ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,08170776 0,10142889 ! protein amino acid acylation GO:0043543 59 28 0,000 0,08170776 0,10137738 ! vesicle docking GO:0048278 55 28 0,000 0,08170776 0,10132592 ! circadian rhythm GO:0007623 56 28 0,000 0,08170776 0,10127451 ! dendrite development GO:0016358 67 28 0,000 0,08170776 0,10122315 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,08170776 0,10117185 ! fat cell differentiation GO:0045444 57 28 0,000 0,08170776 0,1011206 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,08170776 0,1010694 ! sperm motility GO:0030317 37 28 0,000 0,08170776 0,10101825 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,08170776 0,10096715 ! base-excision repair GO:0006284 41 28 0,000 0,08170776 0,10091611 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,08170776 0,10086511 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,08170776 0,10081417 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,08170776 0,10076328 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,08170776 0,10071244 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,08170776 0,10066165 ! glutathione metabolic process GO:0006749 42 28 0,000 0,08170776 0,10061092 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,08170776 0,10056023 ! lipid oxidation GO:0034440 48 28 0,000 0,08170776 0,1005096 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,08170776 0,10045901 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,08450018 0,10384001 ! translational initiation GO:0006413 66 29 0,000 0,08450018 0,1037878 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,08450018 0,10373565 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,08450018 0,10368355 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,08450018 0,1036315 ! autophagy GO:0006914 47 29 0,000 0,08450018 0,1035795 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,08450018 0,10352755 ! primary neural tube formation GO:0014020 61 29 0,000 0,08450018 0,10347566 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,08450018 0,10342382 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,08450018 0,10337203 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,08450018 0,10332029 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,08450018 0,1032686 ! somitogenesis GO:0001756 52 29 0,000 0,08450018 0,10321697 ! synaptogenesis GO:0007416 46 29 0,000 0,08450018 0,10316539 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,08450018 0,10311386 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,08450018 0,10306238 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,08450018 0,10301095 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,08450018 0,10295957 ! phenol metabolic process GO:0018958 56 30 0,000 0,08728419 0,10629874 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,08728419 0,10624577 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,08728419 0,10619286 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,08728419 0,10614 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,08728419 0,1060872 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,08728419 0,10603444 ! acute-phase response GO:0006953 50 30 0,000 0,08728419 0,10598174 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,08728419 0,10592909 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,08728419 0,1058765 ! myofibril assembly GO:0030239 50 30 0,000 0,08728419 0,10582395 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,08728419 0,10577146 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,08728419 0,10571902 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,08728419 0,10566663 ! cell fate determination GO:0001709 64 30 0,000 0,08728419 0,1056143 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,08728419 0,10556201 ! phospholipid transport GO:0015914 65 30 0,000 0,08728419 0,10550978 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,08728419 0,1054576 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,08728419 0,10540547 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,08728419 0,10535339 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,08728419 0,10530137 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,08728419 0,10524939 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,08728419 0,10519747 ! regulation of coagulation GO:0050818 52 30 0,000 0,08728419 0,10514559 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,0900598 0,10843573 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,0900598 0,10838232 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,0900598 0,10832895 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,0900598 0,10827564 ! cell junction assembly GO:0034329 85 31 0,000 0,0900598 0,10822238 ! regulation of innate immune response GO:0045088 57 31 0,000 0,0900598 0,10816917 ! ovulation cycle process GO:0022602 55 31 0,000 0,0900598 0,10811602 ! peptide transport GO:0015833 60 31 0,000 0,0900598 0,10806292 ! male gonad development GO:0008584 56 31 0,000 0,0900598 0,10800987 ! detection of light stimulus GO:0009583 44 31 0,000 0,0900598 0,10795687 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,0900598 0,10790392 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,0900598 0,10785103 ! natural killer cell activation GO:0030101 50 31 0,000 0,0900598 0,10779819 ! cofactor catabolic process GO:0051187 54 31 0,000 0,0900598 0,1077454 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,0900598 0,10769266 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,0900598 0,10763997 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,09282706 0,11089316 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,09282706 0,11083896 ! collagen metabolic process GO:0032963 49 32 0,000 0,09282706 0,11078481 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,09282706 0,11073072 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,09282706 0,11067667 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,09282706 0,11062269 ! muscle cell development GO:0055001 52 32 0,000 0,09282706 0,11056875 ! mesoderm formation GO:0001707 73 32 0,000 0,09282706 0,11051487 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,09282706 0,11046104 ! ovulation cycle GO:0042698 57 32 0,000 0,09282706 0,11040726 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,09282706 0,11035353 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,09282706 0,11029986 ! gene silencing GO:0016458 71 32 0,000 0,09282706 0,11024624 ! regulation of pH GO:0006885 56 33 0,000 0,09558598 0,11346771 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,09558598 0,1134126 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,09558598 0,11335754 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,09558598 0,11330254 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,09558598 0,1132476 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,09558598 0,1131927 ! response to ionizing radiation GO:0010212 74 33 0,000 0,09558598 0,11313786 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,09558598 0,11308307 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,09558598 0,11302834 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,09558598 0,11297365 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,09558598 0,11291902 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,09558598 0,11286445 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,09558598 0,11280992 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,09558598 0,11275545 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,09833658 0,11594414 ! glial cell differentiation GO:0010001 67 34 0,000 0,09833658 0,11588821 ! post-embryonic development GO:0009791 76 34 0,000 0,09833658 0,11583234 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,09833658 0,11577651 ! cholesterol transport GO:0030301 62 34 0,000 0,09833658 0,11572075 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,09833658 0,11566503 ! spliceosome assembly GO:0000245 75 34 0,000 0,09833658 0,11560937 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,09833658 0,11555376 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,09833658 0,11549821 ! formation of primary germ layer GO:0001704 76 34 0,000 0,09833658 0,1154427 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,09833658 0,11538726 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,09833658 0,11533186 ! adult locomotory behavior GO:0008344 62 34 0,000 0,09833658 0,11527652 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,1010789 0,11843441 ! negative regulation of secretion GO:0051048 68 35 0,000 0,1010789 0,11837763 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,1010789 0,11832091 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,1010789 0,11826425 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,1010789 0,11820763 ! membrane docking GO:0022406 69 35 0,000 0,1010789 0,11815107 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,1010789 0,11809457 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,1010789 0,11803812 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,1010789 0,11798172 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,1010789 0,11792538 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,1010789 0,11786909 ! ceramide metabolic process GO:0006672 72 35 0,000 0,1010789 0,11781286 ! sterol transport GO:0015918 63 35 0,000 0,1010789 0,11775667 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,1010789 0,11770055 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,1010789 0,11764447 ! placenta development GO:0001890 53 35 0,000 0,1010789 0,11758845 ! vesicle localization GO:0051648 70 35 0,000 0,1010789 0,11753248 ! regulation of muscle development GO:0048634 82 36 0,000 0,10381295 0,12065416 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,10381295 0,12059678 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,10381295 0,12053947 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,10381295 0,1204822 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,10381295 0,12042499 ! positive regulation of cell development GO:0010720 85 36 0,000 0,10381295 0,12036784 ! protein targeting to membrane GO:0006612 75 36 0,000 0,10381295 0,12031074 ! regulation of proteolysis GO:0030162 77 36 0,000 0,10381295 0,12025369 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,10381295 0,1201967 ! aerobic respiration GO:0009060 56 36 0,000 0,10381295 0,12013976 ! cytokine production GO:0001816 68 36 0,000 0,10381295 0,12008288 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,10381295 0,12002605 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,10381295 0,11996927 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,10653876 0,12306109 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,10653876 0,12300293 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,10653876 0,12294483 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,10653876 0,12288678 ! actomyosin structure organization GO:0031032 68 37 0,000 0,10653876 0,12282879 ! cell junction organization GO:0034330 96 37 0,000 0,10653876 0,12277085 ! tissue remodeling GO:0048771 78 37 0,000 0,10653876 0,12271297 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,10653876 0,12265514 ! female gonad development GO:0008585 71 37 0,000 0,10653876 0,12259736 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,10653876 0,12253964 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,10653876 0,12248198 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,10925636 0,12554718 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,10925636 0,12548815 ! organic anion transport GO:0015711 82 38 0,000 0,10925636 0,12542918 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,10925636 0,12537027 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,10925636 0,12531141 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,10925636 0,1252526 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,10925636 0,12519385 ! regulation of protein stability GO:0031647 77 38 0,000 0,10925636 0,12513516 ! spermatid development GO:0007286 69 38 0,000 0,10925636 0,12507652 ! pigment metabolic process GO:0042440 87 38 0,000 0,10925636 0,12501794 ! cellular response to insulin stimulus GO:0032869 85 38 0,000 0,10925636 0,12495941 ! neural tube formation GO:0001841 79 38 0,000 0,10925636 0,12490093 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,11196577 0,12793844 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,11196577 0,12787863 ! negative regulation of binding GO:0051100 71 39 0,000 0,11196577 0,12781887 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,11196577 0,12775917 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,11196577 0,12769953 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,11196577 0,12763994 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,11196577 0,1275804 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,11196577 0,12752093 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,11196577 0,1274615 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,11196577 0,12740214 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,11466702 0,13041505 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,11466702 0,13035436 ! learning GO:0007612 82 40 0,000 0,11466702 0,13029373 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,11466702 0,13023316 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,11466702 0,13017264 ! mismatch repair GO:0006298 58 40 0,000 0,11466702 0,13011218 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,11466702 0,13005178 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,11466702 0,12999143 ! mRNA catabolic process GO:0006402 79 41 0,000 0,11736012 0,13298274 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,11736012 0,13292108 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,11736012 0,13285949 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,11736012 0,13279795 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,11736012 0,13273647 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,11736012 0,13267505 ! gliogenesis GO:0042063 91 41 0,000 0,11736012 0,13261368 ! feeding behavior GO:0007631 69 41 0,000 0,11736012 0,13255237 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,11736012 0,13249112 ! mesenchymal cell development GO:0014031 94 41 0,000 0,11736012 0,13242992 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,11736012 0,13236878 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,11736012 0,1323077 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,11736012 0,13224667 ! spermatid differentiation GO:0048515 73 41 0,000 0,11736012 0,1321857 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,11736012 0,13212478 ! RNA modification GO:0009451 64 41 0,000 0,11736012 0,13206392 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,12004511 0,13502311 ! organic ether metabolic process GO:0018904 59 42 0,000 0,12004511 0,13496098 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,12004511 0,1348989 ! T cell differentiation GO:0030217 93 42 0,000 0,12004511 0,13483688 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,12004511 0,13477491 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,12004511 0,134713 ! regulation of protein secretion GO:0050708 77 42 0,000 0,12004511 0,13465115 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,12004511 0,13458935 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,12272201 0,13752746 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 0,000 0,12272201 0,1374644 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,12272201 0,1374014 ! regulation of tube size GO:0035150 76 43 0,000 0,12272201 0,13733846 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,12272201 0,13727558 ! glucose transport GO:0015758 66 43 0,000 0,12272201 0,13721275 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,12272201 0,13714998 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,12272201 0,13708727 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,12272201 0,13702462 ! segmentation GO:0035282 78 43 0,000 0,12272201 0,13696202 ! ion transmembrane transport GO:0034220 79 43 0,000 0,12272201 0,13689948 ! neuron migration GO:0001764 85 43 0,000 0,12272201 0,136837 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,12539083 0,139749 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,12539083 0,13968527 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,12539083 0,13962161 ! hexose transport GO:0008645 68 44 0,000 0,12539083 0,139558 GO:0015749|monosaccharide transport, ! striated muscle contraction GO:0006941 85 44 0,000 0,12539083 0,13949445 ! phagocytosis GO:0006909 105 44 0,000 0,12539083 0,13943095 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,12539083 0,13936752 ! double-strand break repair GO:0006302 85 44 0,000 0,12539083 0,13930414 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,12805161 0,1421955 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,12805161 0,14213089 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,12805161 0,14206635 ! biopolymer methylation GO:0043414 91 45 0,000 0,12805161 0,14200186 ! B cell differentiation GO:0030183 124 45 0,000 0,12805161 0,14193743 ! female gamete generation GO:0007292 71 45 0,000 0,12805161 0,14187306 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,12805161 0,14180875 ! polyol metabolic process GO:0019751 77 45 0,000 0,12805161 0,14174449 ! maintenance of location in cell GO:0051651 101 45 0,000 0,12805161 0,1416803 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,13070438 0,14454993 ! glycolysis GO:0006096 71 46 0,000 0,13070438 0,14448452 ! leukocyte migration GO:0050900 75 46 0,000 0,13070438 0,14441917 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,13070438 0,14435389 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,13070438 0,14428866 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,13070438 0,14422348 ! cell growth GO:0016049 90 46 0,000 0,13070438 0,14415837 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,13334914 0,14700901 ! response to insulin stimulus GO:0032868 98 47 0,000 0,13334914 0,1469427 ! positive regulation of defense response GO:0031349 88 48 0,000 0,13598594 0,14978073 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,13598594 0,14971323 ! mitochondrial transport GO:0006839 94 48 0,000 0,13598594 0,14964579 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,13598594 0,14957841 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,13598594 0,14951109 ! endosome transport GO:0016197 127 48 0,000 0,13598594 0,14944384 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,13598594 0,14937664 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,13598594 0,1493095 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,13598594 0,14924243 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,13598594 0,14917541 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,13598594 0,14910846 ! methylation GO:0032259 97 48 0,000 0,13598594 0,14904156 ! response to calcium ion GO:0051592 94 49 0,000 0,13861478 0,15185467 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,13861478 0,15178661 ! JNK cascade GO:0007254 106 49 0,000 0,13861478 0,1517186 ! protein homooligomerization GO:0051260 84 49 0,000 0,13861478 0,15165066 ! regulation of ion transport GO:0043269 86 50 0,000 0,14123571 0,15444889 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,14123571 0,15437979 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,14123571 0,15431075 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,14123571 0,15424177 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,14123571 0,15417285 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,14123571 0,15410399 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,14123571 0,15403519 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,14384873 0,15681501 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,14384873 0,15674507 ! peptide metabolic process GO:0006518 80 51 0,000 0,14384873 0,15667518 ! positive regulation of binding GO:0051099 88 52 0,000 0,14645387 0,15944153 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,14645387 0,15937051 ! Notch signaling pathway GO:0007219 111 52 0,000 0,14645387 0,15929956 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,14645387 0,15922866 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,14645387 0,15915783 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,14645387 0,15908706 ! excretion GO:0007588 87 52 0,000 0,14645387 0,15901636 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,14645387 0,15894571 ! histone modification GO:0016570 104 52 0,000 0,14645387 0,15887513 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,14645387 0,15880462 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,14645387 0,15873416 ! amino acid activation GO:0043038 98 52 0,000 0,14645387 0,15866377 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,14905116 0,16140602 ! positive regulation of growth GO:0045927 96 53 0,000 0,14905116 0,16133451 ! inner ear development GO:0048839 89 53 0,000 0,14905116 0,16126306 ! chromatin remodeling GO:0006338 122 53 0,000 0,14905116 0,16119167 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,14905116 0,16112035 ! vesicle organization GO:0016050 127 53 0,000 0,14905116 0,16104908 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,14905116 0,16097789 ! cartilage development GO:0051216 99 53 0,000 0,14905116 0,16090675 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,15164062 0,16362987 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,15164062 0,16355763 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,15164062 0,16348545 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,15164062 0,16341333 ! membrane fusion GO:0006944 122 54 0,000 0,15164062 0,16334128 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,15164062 0,16326929 ! covalent chromatin modification GO:0016569 115 54 0,000 0,15164062 0,16319737 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,15164062 0,16312551 ! regulation of cell shape GO:0008360 142 54 0,000 0,15164062 0,16305371 ! RNA catabolic process GO:0006401 103 55 0,000 0,15422227 0,16575671 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,15422227 0,16568382 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,15422227 0,16561099 ! cell recognition GO:0008037 98 55 0,000 0,15422227 0,16553823 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,15422227 0,16546553 ! cell maturation GO:0048469 107 55 0,000 0,15422227 0,16539289 ! response to UV GO:0009411 120 55 0,000 0,15422227 0,16532032 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,15422227 0,16524781 ! glucose catabolic process GO:0006007 88 56 0,000 0,15679614 0,16793203 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,15679614 0,16785844 ! RNA elongation GO:0006354 90 56 0,000 0,15679614 0,16778492 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 0,000 0,15936224 0,1704562 ! chloride transport GO:0006821 102 57 0,000 0,15936224 0,1703816 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,15936224 0,17030707 ! heart morphogenesis GO:0003007 105 57 0,000 0,15936224 0,1702326 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,15936224 0,1701582 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,16192061 0,17281436 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,16192061 0,17273889 ! aging GO:0007568 112 58 0,000 0,16192061 0,17266349 ! gastrulation GO:0007369 122 58 0,000 0,16192061 0,17258816 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,16192061 0,17251289 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,16192061 0,17243769 ! maintenance of location GO:0051235 124 58 0,000 0,16192061 0,17236255 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,16701423 0,17770722 ! lipid modification GO:0030258 112 60 0,000 0,16701423 0,17762985 ! regulation of endocytosis GO:0030100 104 60 0,000 0,16701423 0,17755256 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,16701423 0,17747533 ! adult behavior GO:0030534 104 60 0,000 0,16701423 0,17739816 ! positive regulation of secretion GO:0051047 110 61 0,000 0,16954953 0,18001282 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,16954953 0,17993462 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,16954953 0,17985649 ! regulation of heart contraction GO:0008016 123 61 0,000 0,16954953 0,17977843 ! proton transport GO:0015992 117 61 0,000 0,16954953 0,17970044 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,16954953 0,17962251 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,17207718 0,18222131 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,17207718 0,18214236 ! tRNA processing GO:0008033 102 62 0,000 0,17207718 0,18206347 ! mesoderm development GO:0007498 128 63 0,000 0,17459721 0,18464978 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,17459721 0,18456988 ! hydrogen transport GO:0006818 121 64 0,000 0,17710964 0,18714483 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,17710964 0,18706392 ! response to peptide hormone stimulus GO:0043434 129 64 0,000 0,17710964 0,18698308 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,17961449 0,18954566 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,17961449 0,18946382 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,17961449 0,18938205 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,17961449 0,18930035 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,17961449 0,18921872 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,18211179 0,19176686 ! gonad development GO:0008406 115 66 0,000 0,18211179 0,19168423 ! activation of MAPK activity GO:0000187 124 67 0,000 0,18460156 0,19422119 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,18460156 0,19413758 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,18460156 0,19405405 ! secondary metabolic process GO:0019748 125 67 0,000 0,18460156 0,19397058 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,18708381 0,19649431 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,18708381 0,19640987 ! hexose catabolic process GO:0019320 113 68 0,000 0,18708381 0,1963255 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,18708381 0,1962412 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of lipase activity GO:0060191 137 68 0,000 0,18708381 0,19615698 ! adaptive immune response GO:0002250 126 68 0,000 0,18708381 0,19607283 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,18708381 0,19598875 ! cell projection assembly GO:0030031 138 68 0,000 0,18708381 0,19590474 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,18955858 0,19841115 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,18955858 0,19832618 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,18955858 0,19824128 ! developmental maturation GO:0021700 128 69 0,000 0,18955858 0,19815645 ! single fertilization GO:0007338 83 69 0,000 0,18955858 0,19807169 ! cell redox homeostasis GO:0045454 114 70 0,000 0,19202589 0,20056402 ! germ cell development GO:0007281 133 70 0,000 0,19202589 0,20047831 ! activation of immune response GO:0002253 120 70 0,000 0,19202589 0,20039267 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,19202589 0,20030711 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,19448575 0,20278647 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,19448575 0,20269996 ! carbohydrate transport GO:0008643 114 72 0,000 0,1969382 0,20516845 ! actin filament organization GO:0007015 167 72 0,000 0,1969382 0,205081 ! B cell activation GO:0042113 179 72 0,000 0,1969382 0,20499362 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,1969382 0,20490631 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,1969382 0,20481908 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,1969382 0,20473192 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,1969382 0,20464484 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,1969382 0,20455783 ! humoral immune response GO:0006959 115 73 0,000 0,19938324 0,20700946 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,19938324 0,20692152 ! regulation of immune effector process GO:0002697 156 73 0,000 0,19938324 0,20683366 ! acute inflammatory response GO:0002526 118 74 0,000 0,20182091 0,20927355 ! amino acid transport GO:0006865 148 74 0,000 0,20182091 0,20918477 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,20182091 0,20909605 ! regulation of transcription factor activity GO:0051090 137 75 0,000 0,20425123 0,21152427 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 0,000 0,20425123 0,21143464 ! reproductive structure development GO:0048608 131 75 0,000 0,20425123 0,21134509 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,20425123 0,21125561 ! rhythmic process GO:0048511 142 75 0,000 0,20425123 0,21116621 ! learning or memory GO:0007611 161 76 0,000 0,20667422 0,21358084 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,20667422 0,21349053 ! regulation of blood pressure GO:0008217 134 76 0,000 0,20667422 0,2134003 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,20667422 0,21331014 ! amine catabolic process GO:0009310 136 77 0,000 0,20908989 0,21571225 ! neurotransmitter transport GO:0006836 142 77 0,000 0,20908989 0,21562119 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,20908989 0,21553021 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,20908989 0,21543931 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,20908989 0,21534848 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,20908989 0,21525774 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,20908989 0,21516706 ! regulation of catabolic process GO:0009894 173 77 0,000 0,20908989 0,21507647 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,21149828 0,21746225 ! antigen processing and presentation GO:0019882 117 78 0,000 0,21149828 0,21737076 ! fertilization GO:0009566 99 78 0,000 0,21149828 0,21727935 ! blood coagulation GO:0007596 151 79 0,000 0,2138994 0,21965374 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,2138994 0,21956144 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,2138994 0,21946923 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,2138994 0,21937709 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,2138994 0,21928503 ! positive regulation of phosphorylation GO:0042327 149 81 0,000 0,21867993 0,2240919 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,21867993 0,22399794 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,22343166 0,2287693 ! exocytosis GO:0006887 153 83 0,000 0,22343166 0,22867346 ! response to drug GO:0042493 149 83 0,000 0,22343166 0,2285777 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,22343166 0,22848202 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 0,000 0,22343166 0,22838642 GO:0045937|positive regulation of phosphate metabolic process, ! inorganic anion transport GO:0015698 156 83 0,000 0,22343166 0,2282909 ! response to metal ion GO:0010038 158 84 0,000 0,22579678 0,23061101 ! T cell activation GO:0042110 189 84 0,000 0,22579678 0,23051464 ! response to nutrient GO:0007584 135 84 0,000 0,22579678 0,23041835 ! digestion GO:0007586 130 84 0,000 0,22579678 0,23032214 ! regulation of ligase activity GO:0051340 147 84 0,000 0,22579678 0,23022601 ! hemostasis GO:0007599 165 85 0,000 0,22815476 0,2325332 ! negative regulation of transport GO:0051051 164 85 0,000 0,22815476 0,23243623 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,22815476 0,23233934 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,22815476 0,23224253 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,22815476 0,2321458 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,22815476 0,23204916 ! cellular response to hormone stimulus GO:0032870 182 85 0,000 0,22815476 0,23195259 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,23050562 0,2342451 ! regulation of lyase activity GO:0051339 169 86 0,000 0,23050562 0,23414771 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,23284939 0,2364302 ! alcohol catabolic process GO:0046164 142 87 0,000 0,23284939 0,23633197 ! nucleosome assembly GO:0006334 126 87 0,000 0,23284939 0,23623383 ! cellular respiration GO:0045333 143 88 0,000 0,23518609 0,23850544 ! amine biosynthetic process GO:0009309 146 88 0,000 0,23518609 0,23840648 ! sensory perception of smell GO:0007608 117 88 0,000 0,23518609 0,2383076 ! chromatin assembly GO:0031497 128 88 0,000 0,23518609 0,23820879 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,23518609 0,23811008 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,23751573 0,24036907 ! regulation of DNA binding GO:0051101 167 89 0,000 0,23751573 0,24026954 ! cellular defense response GO:0006968 123 89 0,000 0,23751573 0,24017009 ! regulation of neurological system process GO:0031644 175 89 0,000 0,23751573 0,24007072 ! response to inorganic substance GO:0010035 173 90 0,000 0,23983835 0,24231807 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,23983835 0,24221789 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,23983835 0,2421178 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,24215395 0,24435444 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,24215395 0,24425355 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,24446257 0,24648042 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,24676422 0,24869843 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,24676422 0,24859587 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,24676422 0,2484934 ! vitamin metabolic process GO:0006766 153 93 0,000 0,24676422 0,24839101 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,24905892 0,25059759 ! female pregnancy GO:0007565 166 94 0,000 0,24905892 0,25049442 ! sterol metabolic process GO:0016125 166 94 0,000 0,24905892 0,25039133 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,24905892 0,25028833 ! regulation of defense response GO:0031347 171 95 0,000 0,25134669 0,25248354 ! nucleosome organization GO:0034728 143 95 0,000 0,25134669 0,25237977 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,25134669 0,25227608 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,25134669 0,25217247 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,25134669 0,25206895 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,25134669 0,25196552 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,25134669 0,25186217 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,25590155 0,25632123 ! leukocyte differentiation GO:0002521 232 98 0,000 0,25816867 0,25848609 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,25816867 0,2583802 ! positive regulation of immune response GO:0050778 175 100 0,000 0,2626824 0,26278997 ! hormone metabolic process GO:0042445 171 100 0,000 0,2626824 0,2626824