pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6571-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 3,000 1,078E-08 2,633E-05 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 7,000 2,562E-08 3,13E-05 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 7,000 3,604E-08 2,934E-05 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 7,000 3,604E-08 2,201E-05 ! positive regulation of ligase activity GO:0051351 130 77 7,000 6,151E-08 3,005E-05 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 7,000 7,537E-08 3,069E-05 ! regulation of ligase activity GO:0051340 147 84 7,000 1,223E-07 4,268E-05 ! apoptotic mitochondrial changes GO:0008637 42 20 4,000 2,085E-07 6,368E-05 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 6,000 4,474E-07 1,214E-04 ! insulin receptor signaling pathway GO:0008286 66 27 4,000 1,044E-06 2,551E-04 ! release of cytochrome c from mitochondria GO:0001836 31 14 3,000 2,055E-06 4,563E-04 ! cellular response to extracellular stimulus GO:0031668 52 31 4,000 2,149E-06 4,375E-04 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 2,000 3,163E-06 5,944E-04 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 6,000 3,78E-06 6,596E-04 GO:0010498|proteasomal protein catabolic process, ! response to peptide hormone stimulus GO:0043434 129 64 5,000 5,289E-06 8,613E-04 ! cell junction organization GO:0034330 96 37 4,000 5,331E-06 8,139E-04 ! cellular response to insulin stimulus GO:0032869 85 38 4,000 6,104E-06 8,772E-04 ! deoxyribonucleoside metabolic process GO:0009120 11 6 2,000 6,294E-06 8,543E-04 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 5,000 6,92E-06 8,897E-04 ! negative regulation of ligase activity GO:0051352 116 68 5,000 7,546E-06 9,217E-04 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! peptidyl-serine phosphorylation GO:0018105 44 20 3,000 9,628E-06 1,12E-03 ! B cell lineage commitment GO:0002326 21 7 2,000 1,096E-05 1,217E-03 ! T cell lineage commitment GO:0002360 16 7 2,000 1,096E-05 1,164E-03 ! cellular response to starvation GO:0009267 37 22 3,000 1,438E-05 1,464E-03 ! peptidyl-serine modification GO:0018209 50 22 3,000 1,438E-05 1,405E-03 ! response to ethanol GO:0045471 47 23 3,000 1,731E-05 1,627E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 3,000 1,731E-05 1,567E-03 ! deoxyribonucleotide metabolic process GO:0009262 37 23 3,000 1,731E-05 1,511E-03 ! ER overload response GO:0006983 13 8 2,000 1,745E-05 1,47E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,745E-05 1,421E-03 ! response to insulin stimulus GO:0032868 98 47 4,000 1,774E-05 1,398E-03 ! response to drug GO:0042493 149 83 5,000 2,388E-05 1,823E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 2,603E-05 1,927E-03 ! mitochondrion organization GO:0007005 159 87 5,000 3,123E-05 2,244E-03 ! positive regulation of growth GO:0045927 96 53 4,000 3,209E-05 2,24E-03 ! response to starvation GO:0042594 47 27 3,000 3,358E-05 2,279E-03 ! cellular response to nutrient levels GO:0031669 45 27 3,000 3,358E-05 2,217E-03 ! regulation of developmental growth GO:0048638 16 10 2,000 3,7E-05 2,379E-03 ! protein sumoylation GO:0016925 17 10 2,000 3,7E-05 2,318E-03 ! response to UV GO:0009411 120 55 4,000 3,847E-05 2,35E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 4,000 4,579E-05 2,728E-03 ! regulation of membrane potential GO:0042391 179 94 5,000 4,838E-05 2,814E-03 ! regulation of embryonic development GO:0045995 35 11 2,000 5,062E-05 2,876E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 3,000 5,16E-05 2,865E-03 ! cell junction assembly GO:0034329 85 31 3,000 5,893E-05 3,199E-03 ! positive regulation of cellular catabolic process GO:0031331 34 12 2,000 6,715E-05 3,566E-03 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 2,000 6,715E-05 3,491E-03 ! focal adhesion formation GO:0048041 37 12 2,000 6,715E-05 3,418E-03 ! T cell homeostasis GO:0043029 28 12 2,000 6,715E-05 3,348E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 4,000 8,019E-05 3,918E-03 ! regulation of skeletal muscle fiber development GO:0048742 32 13 2,000 8,686E-05 4,161E-03 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 2,000 8,686E-05 4,081E-03 ! response to gamma radiation GO:0010332 30 14 2,000 1,1E-04 5,07E-03 ! negative regulation of cell size GO:0045792 144 69 4,000 1,15E-04 5,201E-03 ! regulation of skeletal muscle tissue development GO:0048641 35 15 2,000 1,368E-04 6,076E-03 ! negative regulation of bone remodeling GO:0046851 34 15 2,000 1,368E-04 5,967E-03 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 2,000 1,368E-04 5,863E-03 ! lymphocyte homeostasis GO:0002260 33 15 2,000 1,368E-04 5,761E-03 ! learning GO:0007612 82 40 3,000 1,631E-04 6,752E-03 ! negative regulation of tissue remodeling GO:0034104 37 16 2,000 1,675E-04 6,82E-03 ! cell-matrix adhesion GO:0007160 181 76 4,000 1,818E-04 7,279E-03 ! regulation of survival gene product expression GO:0045884 38 17 2,000 2,024E-04 7,974E-03 ! negative regulation of homeostatic process GO:0032845 36 17 2,000 2,024E-04 7,847E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 2,416E-04 9,222E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 2,416E-04 9,08E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 2,588E-04 9,579E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 2,596E-04 9,467E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 3,000 2,819E-04 0,01012845 ! pigmentation GO:0043473 103 46 3,000 2,819E-04 9,982E-03 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 2,000 2,854E-04 9,962E-03 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 38 19 2,000 2,854E-04 9,822E-03 ! visual learning GO:0008542 38 19 2,000 2,854E-04 9,685E-03 ! cellular pigmentation GO:0033059 37 19 2,000 2,854E-04 9,553E-03 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 3,07E-04 0,01013351 ! response to alkaloid GO:0043279 38 20 2,000 3,341E-04 0,01088353 ! cell-cell junction organization GO:0045216 43 20 2,000 3,341E-04 0,01074032 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 3,878E-04 0,01230509 ! gland development GO:0048732 220 91 4,000 4,209E-04 0,01318346 ! glutamate signaling pathway GO:0007215 48 22 2,000 4,468E-04 0,01381707 ! D-ribose metabolic process GO:0006014 36 22 2,000 4,468E-04 0,01364436 ! cell aging GO:0007569 48 22 2,000 4,468E-04 0,01347591 ! cytolysis GO:0019835 27 22 2,000 4,468E-04 0,01331157 ! renal system process GO:0003014 42 22 2,000 4,468E-04 0,01315119 ! response to glucocorticoid stimulus GO:0051384 42 22 2,000 4,468E-04 0,01299463 ! DNA-dependent DNA replication GO:0006261 82 52 3,000 4,529E-04 0,0130166 ! positive regulation of muscle development GO:0048636 15 5 1,000 4,63E-04 0,01315153 GO:0045844|positive regulation of striated muscle development, ! negative regulation of bone resorption GO:0045779 10 5 1,000 4,63E-04 0,01300037 ! hypothalamus development GO:0021854 9 5 1,000 4,63E-04 0,01285264 ! lipoprotein particle clearance GO:0034381 10 5 1,000 4,63E-04 0,01270822 ! positive regulation of glycolysis GO:0045821 13 5 1,000 4,63E-04 0,01256702 ! anagen GO:0042640 7 5 1,000 4,63E-04 0,01242892 ! skeletal myofibril assembly GO:0014866 12 5 1,000 4,63E-04 0,01229383 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 4,63E-04 0,01216163 ! microvillus organization GO:0032528 8 5 1,000 4,63E-04 0,01203226 GO:0030033|microvillus assembly, ! response to food GO:0032094 6 5 1,000 4,63E-04 0,0119056 ! lipoprotein catabolic process GO:0042159 11 5 1,000 4,63E-04 0,01178158 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 1,000 4,63E-04 0,01166012 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 4,63E-04 0,01154114 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 1,000 4,63E-04 0,01142457 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 4,63E-04 0,01131032 ! meiotic chromosome segregation GO:0045132 10 5 1,000 4,63E-04 0,01119834 ! response to mercury ion GO:0046689 8 5 1,000 4,63E-04 0,01108855 ! B cell homeostasis GO:0001782 13 5 1,000 4,63E-04 0,01098089 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 4,63E-04 0,01087531 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 4,63E-04 0,01077173 ! regulation of sensory perception GO:0051931 8 5 1,000 4,63E-04 0,01067011 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 4,63E-04 0,01057039 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 4,63E-04 0,01047252 GO:0022011|myelination in the peripheral nervous system, ! synapse organization GO:0050808 102 53 3,000 4,872E-04 0,01092046 ! visual behavior GO:0007632 46 23 2,000 5,112E-04 0,01135397 ! regulation of multicellular organism growth GO:0040014 90 55 3,000 5,614E-04 0,01235676 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 5,813E-04 0,01267985 ! response to corticosteroid stimulus GO:0031960 46 24 2,000 5,813E-04 0,01256764 ! negative regulation of phosphorylation GO:0042326 52 24 2,000 5,813E-04 0,0124574 ! membrane depolarization GO:0051899 45 24 2,000 5,813E-04 0,01234907 ! pyrimidine nucleoside metabolic process GO:0006213 34 24 2,000 5,813E-04 0,01224262 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 5,813E-04 0,01213798 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 6,572E-04 0,01360718 ! leukocyte homeostasis GO:0001776 50 25 2,000 6,572E-04 0,01349284 ! protein tetramerization GO:0051262 57 25 2,000 6,572E-04 0,0133804 ! positive regulation of cell migration GO:0030335 137 58 3,000 6,873E-04 0,0138765 ! regulation of respiratory gaseous exchange GO:0043576 9 6 1,000 6,913E-04 0,01384311 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 1,000 6,913E-04 0,01373057 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 6,913E-04 0,01361984 ! establishment of spindle localization GO:0051293 16 6 1,000 6,913E-04 0,01351088 GO:0051653|spindle localization, ! neural nucleus development GO:0048857 19 6 1,000 6,913E-04 0,01340365 ! astrocyte development GO:0014002 16 6 1,000 6,913E-04 0,01329811 ! hair follicle maturation GO:0048820 8 6 1,000 6,913E-04 0,01319422 ! Schwann cell development GO:0014044 15 6 1,000 6,913E-04 0,01309194 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 6,913E-04 0,01299123 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 6,913E-04 0,01289206 ! triglyceride catabolic process GO:0019433 10 6 1,000 6,913E-04 0,01279439 ! cytoplasmic microtubule organization GO:0031122 18 6 1,000 6,913E-04 0,01269819 ! myelination GO:0042552 50 26 2,000 7,392E-04 0,01347697 ! molting cycle process GO:0022404 52 26 2,000 7,392E-04 0,01337715 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 2,000 7,392E-04 0,01327878 GO:0045936|negative regulation of phosphate metabolic process, ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 7,392E-04 0,01318186 ! pentose metabolic process GO:0019321 43 26 2,000 7,392E-04 0,01308634 ! mitochondrial membrane organization GO:0007006 60 27 2,000 8,274E-04 0,01454243 ! regulation of chromosome organization GO:0033044 49 27 2,000 8,274E-04 0,01443856 ! regulation of homeostatic process GO:0032844 148 62 3,000 8,845E-04 0,0153256 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 9,22E-04 0,01586297 ! regulation of mitosis GO:0007088 112 63 3,000 9,395E-04 0,01604965 GO:0051783|regulation of nuclear division, ! regulation of helicase activity GO:0051095 16 7 1,000 9,634E-04 0,0163451 ! prostate gland development GO:0030850 14 7 1,000 9,634E-04 0,01623238 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 9,634E-04 0,0161212 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 9,634E-04 0,01601153 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 9,634E-04 0,01590334 ! mRNA stabilization GO:0048255 18 7 1,000 9,634E-04 0,01579661 GO:0043489|RNA stabilization, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 9,634E-04 0,0156913 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 1,000 9,634E-04 0,01558738 ! glycerol ether catabolic process GO:0044269 12 7 1,000 9,634E-04 0,01548483 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 1,000 9,634E-04 0,01538362 ! male sex determination GO:0030238 15 7 1,000 9,634E-04 0,01528373 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 9,634E-04 0,01518513 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 9,634E-04 0,01508779 ! peptidyl-threonine modification GO:0018210 26 7 1,000 9,634E-04 0,01499169 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 9,634E-04 0,0148968 ! endosome to lysosome transport GO:0008333 12 7 1,000 9,634E-04 0,01480311 ! integrin-mediated signaling pathway GO:0007229 160 64 3,000 9,967E-04 0,01521903 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 1,023E-03 0,01552656 ! response to organic cyclic substance GO:0014070 58 29 2,000 1,023E-03 0,01543072 ! synaptogenesis GO:0007416 46 29 2,000 1,023E-03 0,01533605 ! positive regulation of cell motion GO:0051272 157 65 3,000 1,056E-03 0,01573708 ! complement activation, classical pathway GO:0006958 51 30 2,000 1,131E-03 0,01674862 ! negative regulation of cell growth GO:0030308 142 67 3,000 1,183E-03 0,01741417 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 1,246E-03 0,01822868 ! ensheathment of neurons GO:0007272 64 31 2,000 1,246E-03 0,01812018 GO:0008366|axon ensheathment, ! response to heat GO:0009408 54 31 2,000 1,246E-03 0,01801296 ! adaptive immune response GO:0002250 126 68 3,000 1,251E-03 0,01797089 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,279E-03 0,01826932 ! oligopeptide transport GO:0006857 16 8 1,000 1,279E-03 0,0181631 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,279E-03 0,01805811 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,279E-03 0,01795433 ! glycerolipid catabolic process GO:0046503 14 8 1,000 1,279E-03 0,01785173 ! pigment granule organization GO:0048753 17 8 1,000 1,279E-03 0,0177503 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,279E-03 0,01765002 ! astrocyte differentiation GO:0048708 19 8 1,000 1,279E-03 0,01755086 ! L-phenylalanine metabolic process GO:0006558 12 8 1,000 1,279E-03 0,01745281 GO:0006559|L-phenylalanine catabolic process, ! regulation of pigmentation during development GO:0048070 25 8 1,000 1,279E-03 0,01735585 ! melanin metabolic process GO:0006582 17 8 1,000 1,279E-03 0,01725996 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,279E-03 0,01716513 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,279E-03 0,01707133 ! Schwann cell differentiation GO:0014037 21 8 1,000 1,279E-03 0,01697855 ! response to UV-B GO:0010224 17 8 1,000 1,279E-03 0,01688677 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 1,279E-03 0,01679599 ! response to tumor cell GO:0002347 16 8 1,000 1,279E-03 0,01670617 ! regulation of respiratory burst GO:0060263 12 8 1,000 1,279E-03 0,01661731 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 1,279E-03 0,01652938 ! lung development GO:0030324 165 69 3,000 1,32E-03 0,01697775 ! urogenital system development GO:0001655 149 69 3,000 1,32E-03 0,01688886 ! spindle organization GO:0007051 50 32 2,000 1,368E-03 0,01740717 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 2,000 1,368E-03 0,01731698 ! peripheral nervous system development GO:0007422 68 32 2,000 1,368E-03 0,01722772 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,368E-03 0,01713937 ! activation of immune response GO:0002253 120 70 3,000 1,393E-03 0,01736248 ! response to ionizing radiation GO:0010212 74 33 2,000 1,497E-03 0,01856789 ! respiratory tube development GO:0030323 171 72 3,000 1,546E-03 0,01907969 ! actin filament organization GO:0007015 167 72 3,000 1,546E-03 0,01898381 ! humoral immune response GO:0006959 115 73 3,000 1,627E-03 0,0198775 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,637E-03 0,01989287 ! cell proliferation in forebrain GO:0021846 18 9 1,000 1,637E-03 0,01979439 ! neutral lipid catabolic process GO:0046461 14 9 1,000 1,637E-03 0,01969689 ! induction of positive chemotaxis GO:0050930 17 9 1,000 1,637E-03 0,01960033 ! regulation of glycolysis GO:0006110 20 9 1,000 1,637E-03 0,01950472 ! cerebral cortex cell migration GO:0021795 18 9 1,000 1,637E-03 0,01941004 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 1,637E-03 0,01931627 ! microtubule bundle formation GO:0001578 22 9 1,000 1,637E-03 0,0192234 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,637E-03 0,01913142 ! T cell selection GO:0045058 27 9 1,000 1,637E-03 0,01904032 ! nucleoside diphosphate metabolic process GO:0009132 17 9 1,000 1,637E-03 0,01895008 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,637E-03 0,0188607 ! regulation of synaptogenesis GO:0051963 15 9 1,000 1,637E-03 0,01877215 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,637E-03 0,01868443 ! respiratory system development GO:0060541 175 74 3,000 1,711E-03 0,01944326 ! regulation of striated muscle tissue development GO:0016202 81 35 2,000 1,778E-03 0,02011063 ! learning or memory GO:0007611 161 76 3,000 1,888E-03 0,02125189 ! regulation of muscle development GO:0048634 82 36 2,000 1,93E-03 0,02162819 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 2,000 1,93E-03 0,02152943 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 2,037E-03 0,02261584 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 2,037E-03 0,02251351 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 2,037E-03 0,02241209 ! lung alveolus development GO:0048286 26 10 1,000 2,037E-03 0,02231159 ! glucan biosynthetic process GO:0009250 14 10 1,000 2,037E-03 0,02221199 GO:0005978|glycogen biosynthetic process, ! B cell proliferation GO:0042100 19 10 1,000 2,037E-03 0,02211327 ! epithelial cell development GO:0002064 21 10 1,000 2,037E-03 0,02201542 ! intestinal cholesterol absorption GO:0030299 19 10 1,000 2,037E-03 0,02191843 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 2,037E-03 0,0218223 ! motor axon guidance GO:0008045 22 10 1,000 2,037E-03 0,02172701 ! regulation of bone resorption GO:0045124 25 10 1,000 2,037E-03 0,02163254 ! protein heterooligomerization GO:0051291 17 10 1,000 2,037E-03 0,02153889 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 2,037E-03 0,02144605 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 2,037E-03 0,02135401 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 2,037E-03 0,02126276 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 2,037E-03 0,02117228 ! regulation of microtubule-based process GO:0032886 86 37 2,000 2,09E-03 0,02163202 ! meiosis I GO:0007127 74 38 2,000 2,257E-03 0,02326947 ! glycogen metabolic process GO:0005977 63 38 2,000 2,257E-03 0,0231717 ! meiosis GO:0007126 143 81 3,000 2,384E-03 0,0243641 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 3,000 2,384E-03 0,02426258 ! carbohydrate homeostasis GO:0033500 59 39 2,000 2,433E-03 0,02466555 GO:0042593|glucose homeostasis, ! glucan metabolic process GO:0044042 64 39 2,000 2,433E-03 0,02456363 GO:0006073|cellular glucan metabolic process, ! telencephalon cell migration GO:0022029 23 11 1,000 2,478E-03 0,02491221 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,478E-03 0,02481011 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 2,478E-03 0,02470884 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,478E-03 0,0246084 ! blood vessel remodeling GO:0001974 30 11 1,000 2,478E-03 0,02450877 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 2,478E-03 0,02440994 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,478E-03 0,02431191 ! regulation of intracellular pH GO:0051453 21 11 1,000 2,478E-03 0,02421466 ! behavioral fear response GO:0001662 27 11 1,000 2,478E-03 0,02411819 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 2,478E-03 0,02402248 ! alpha-beta T cell activation GO:0046631 26 11 1,000 2,478E-03 0,02392753 ! DNA methylation GO:0006306 19 11 1,000 2,478E-03 0,02383333 GO:0006305|DNA alkylation, ! apical protein localization GO:0045176 18 11 1,000 2,478E-03 0,02373987 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 2,478E-03 0,02364713 ! thymus development GO:0048538 29 11 1,000 2,478E-03 0,02355512 ! oocyte development GO:0048599 20 11 1,000 2,478E-03 0,02346382 ! T cell receptor signaling pathway GO:0050852 29 11 1,000 2,478E-03 0,02337323 ! meiotic cell cycle GO:0051321 144 82 3,000 2,492E-03 0,02341965 ! response to oxygen levels GO:0070482 183 83 3,000 2,605E-03 0,02438098 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 2,000 2,617E-03 0,02440487 GO:0006956|complement activation, ! regulation of action potential in neuron GO:0019228 80 40 2,000 2,617E-03 0,02431208 ! cholesterol metabolic process GO:0008203 148 85 3,000 2,84E-03 0,02627763 ! negative regulation of growth GO:0045926 168 85 3,000 2,84E-03 0,02617847 ! regulation of neuron differentiation GO:0045664 187 85 3,000 2,84E-03 0,02608005 ! virus-host interaction GO:0019048 30 12 1,000 2,96E-03 0,0270846 ! regulation of B cell proliferation GO:0030888 22 12 1,000 2,96E-03 0,02698354 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 2,96E-03 0,02688323 GO:0050927|positive regulation of positive chemotaxis, ! drug transport GO:0015893 16 12 1,000 2,96E-03 0,02678366 ! tyrosine metabolic process GO:0006570 19 12 1,000 2,96E-03 0,02668483 ! forebrain cell migration GO:0021885 24 12 1,000 2,96E-03 0,02658672 ! lipid digestion GO:0044241 21 12 1,000 2,96E-03 0,02648933 ! synaptic vesicle exocytosis GO:0016079 22 12 1,000 2,96E-03 0,02639266 ! histone acetylation GO:0016573 27 12 1,000 2,96E-03 0,02629668 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,96E-03 0,02620141 ! regulation of leukocyte migration GO:0002685 29 12 1,000 2,96E-03 0,02610682 ! oocyte differentiation GO:0009994 21 12 1,000 2,96E-03 0,02601291 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 2,96E-03 0,02591967 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 2,96E-03 0,0258271 ! regulation of synapse organization GO:0050807 18 12 1,000 2,96E-03 0,02573519 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 3,011E-03 0,02608191 ! T cell differentiation GO:0030217 93 42 2,000 3,011E-03 0,02598974 ! epithelial cell differentiation GO:0030855 83 43 2,000 3,22E-03 0,02770081 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 2,000 3,22E-03 0,02760362 ! glucose transport GO:0015758 66 43 2,000 3,22E-03 0,0275071 ! regulation of neurological system process GO:0031644 175 89 3,000 3,352E-03 0,02853419 ! response to reactive oxygen species GO:0000302 75 44 2,000 3,439E-03 0,02916768 ! energy reserve metabolic process GO:0006112 76 44 2,000 3,439E-03 0,02906675 ! hexose transport GO:0008645 68 44 2,000 3,439E-03 0,02896652 GO:0015749|monosaccharide transport, ! cartilage condensation GO:0001502 22 13 1,000 3,483E-03 0,02923657 ! Golgi organization GO:0007030 25 13 1,000 3,483E-03 0,02913644 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 3,483E-03 0,029037 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 3,483E-03 0,02893824 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 3,483E-03 0,02884014 ! response to X-ray GO:0010165 28 13 1,000 3,483E-03 0,02874271 ! asymmetric protein localization GO:0008105 24 13 1,000 3,483E-03 0,02864593 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,483E-03 0,0285498 ! gland morphogenesis GO:0022612 31 13 1,000 3,483E-03 0,02845432 ! aromatic amino acid family catabolic process GO:0009074 20 13 1,000 3,483E-03 0,02835947 ! spleen development GO:0048536 24 13 1,000 3,483E-03 0,02826526 ! regulation of mRNA stability GO:0043488 32 13 1,000 3,483E-03 0,02817166 ! digestive tract morphogenesis GO:0048546 31 13 1,000 3,483E-03 0,02807869 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 3,483E-03 0,02798632 ! regulation of synapse structure and activity GO:0050803 19 13 1,000 3,483E-03 0,02789456 ! regulation of cell cycle process GO:0010564 161 90 3,000 3,489E-03 0,02785868 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 3,666E-03 0,02916988 ! B cell differentiation GO:0030183 124 45 2,000 3,666E-03 0,02907517 ! developmental growth GO:0048589 88 45 2,000 3,666E-03 0,02898108 ! regulation of cell adhesion GO:0030155 241 92 3,000 3,775E-03 0,02975298 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 3,902E-03 0,03064913 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 3,902E-03 0,0305509 ! regulation of cell morphogenesis GO:0022604 243 93 3,000 3,924E-03 0,03062901 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 3,924E-03 0,03053146 ! hair follicle morphogenesis GO:0031069 27 14 1,000 4,045E-03 0,03136836 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 1,000 4,045E-03 0,03126909 ! cell-cell junction assembly GO:0007043 32 14 1,000 4,045E-03 0,03117045 ! fear response GO:0042596 34 14 1,000 4,045E-03 0,03107243 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 4,045E-03 0,03097503 GO:0060675|ureteric bud morphogenesis, ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 4,045E-03 0,03087823 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 4,045E-03 0,03078204 ! regulation of cellular pH GO:0030641 27 14 1,000 4,045E-03 0,03068644 ! regulation of RNA stability GO:0043487 33 14 1,000 4,045E-03 0,03059143 ! sterol metabolic process GO:0016125 166 94 3,000 4,077E-03 0,03074046 ! regulation of JNK cascade GO:0046328 104 47 2,000 4,147E-03 0,03117147 ! positive regulation of cell cycle GO:0045787 96 48 2,000 4,401E-03 0,03298143 ! mitochondrial transport GO:0006839 94 48 2,000 4,401E-03 0,03288057 ! cellular component disassembly GO:0022411 89 48 2,000 4,401E-03 0,03278032 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 2,000 4,401E-03 0,03268068 ! regulation of DNA metabolic process GO:0051052 188 97 3,000 4,559E-03 0,03375028 ! regulation of protein localization GO:0032880 188 97 3,000 4,559E-03 0,03364831 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 4,646E-03 0,03418609 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 4,646E-03 0,03408343 ! G1/S transition checkpoint GO:0031575 37 15 1,000 4,646E-03 0,03398138 ! intermediate filament cytoskeleton organization GO:0045104 34 15 1,000 4,646E-03 0,03387995 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 4,646E-03 0,03377911 ! intestinal absorption GO:0050892 31 15 1,000 4,646E-03 0,03367888 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 4,665E-03 0,0337153 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 4,728E-03 0,03407099 ! regulation of action potential GO:0001508 102 50 2,000 4,938E-03 0,03547775 ! activation of caspase activity GO:0006919 95 50 2,000 4,938E-03 0,03537371 ! immunoglobulin mediated immune response GO:0016064 89 50 2,000 4,938E-03 0,03527028 GO:0019724|B cell mediated immunity, ! skeletal muscle tissue development GO:0007519 223 100 3,000 5,078E-03 0,03616781 GO:0060538|skeletal muscle organ development, ! positive regulation of immune response GO:0050778 175 100 3,000 5,078E-03 0,03606267 ! response to temperature stimulus GO:0009266 84 51 2,000 5,22E-03 0,03696279 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 5,286E-03 0,03732001 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 5,286E-03 0,03721246 ! startle response GO:0001964 28 16 1,000 5,286E-03 0,03710553 ! pituitary gland development GO:0021983 30 16 1,000 5,286E-03 0,03699921 ! lysosomal transport GO:0007041 31 16 1,000 5,286E-03 0,0368935 ! intermediate filament-based process GO:0045103 36 16 1,000 5,286E-03 0,03678839 ! axon cargo transport GO:0008088 46 16 1,000 5,286E-03 0,03668387 ! DNA replication initiation GO:0006270 28 16 1,000 5,286E-03 0,03657995 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 5,286E-03 0,03647662 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 5,286E-03 0,03637387 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 5,512E-03 0,03782351 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 5,813E-03 0,03978056 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 2,000 5,813E-03 0,03966944 ! metencephalon development GO:0022037 32 17 1,000 5,963E-03 0,04058079 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 5,963E-03 0,04046807 ! glial cell development GO:0021782 28 17 1,000 5,963E-03 0,04035597 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 5,963E-03 0,04024449 ! complement activation, alternative pathway GO:0006957 19 17 1,000 5,963E-03 0,04013362 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 5,963E-03 0,04002337 GO:0031114|regulation of microtubule depolymerization, ! regulation of protein binding GO:0043393 33 17 1,000 5,963E-03 0,03991371 ! DNA unwinding during replication GO:0006268 26 17 1,000 5,963E-03 0,03980466 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 5,963E-03 0,0396962 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 5,963E-03 0,03958833 ! regulation of angiogenesis GO:0045765 125 54 2,000 6,124E-03 0,04054698 ! regulation of cell shape GO:0008360 142 54 2,000 6,124E-03 0,04043739 ! limbic system development GO:0021761 40 18 1,000 6,679E-03 0,04397787 ! regulation of viral genome replication GO:0045069 30 18 1,000 6,679E-03 0,04385965 ! positive regulation of proteolysis GO:0045862 36 18 1,000 6,679E-03 0,04374206 ! epidermis morphogenesis GO:0048730 43 18 1,000 6,679E-03 0,04362511 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 6,679E-03 0,04350877 ! defense response to virus GO:0051607 43 18 1,000 6,679E-03 0,04339306 ! positive regulation of synaptic transmission GO:0050806 35 18 1,000 6,679E-03 0,04327796 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 6,679E-03 0,04316346 ! skeletal muscle fiber development GO:0048741 130 56 2,000 6,776E-03 0,0436781 ! regulation of DNA replication GO:0006275 105 56 2,000 6,776E-03 0,04356316 ! regulation of bone remodeling GO:0046850 143 57 2,000 7,117E-03 0,04563347 ! positive regulation of caspase activity GO:0043280 108 57 2,000 7,117E-03 0,04551401 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 2,000 7,117E-03 0,04539517 ! regulation of intracellular transport GO:0032386 108 57 2,000 7,117E-03 0,04527696 ! inositol metabolic process GO:0006020 33 19 1,000 7,431E-03 0,0471513 ! cerebral cortex development GO:0021987 40 19 1,000 7,431E-03 0,04702915 ! neuromuscular junction development GO:0007528 43 19 1,000 7,431E-03 0,04690763 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 7,431E-03 0,04678673 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 1,000 7,431E-03 0,04666646 ! cellular polysaccharide metabolic process GO:0044264 93 58 2,000 7,468E-03 0,04677721 ! aging GO:0007568 112 58 2,000 7,468E-03 0,04665758 ! regulation of tissue remodeling GO:0034103 146 58 2,000 7,468E-03 0,04653856 ! establishment of organelle localization GO:0051656 122 59 2,000 7,828E-03 0,04866272 ! kidney development GO:0001822 133 60 2,000 8,199E-03 0,05083886 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 8,219E-03 0,05083439 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 8,219E-03 0,05070602 ! protein amino acid acetylation GO:0006473 41 20 1,000 8,219E-03 0,0505783 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 8,219E-03 0,05045122 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 8,219E-03 0,05032477 GO:0010675|regulation of cellular carbohydrate metabolic process, ! DNA duplex unwinding GO:0032508 30 20 1,000 8,219E-03 0,05019896 GO:0032392|DNA geometric change, ! actin filament bundle formation GO:0051017 47 20 1,000 8,219E-03 0,05007378 ! positive regulation of neurological system process GO:0031646 39 20 1,000 8,219E-03 0,04994921 ! aromatic compound catabolic process GO:0019439 31 20 1,000 8,219E-03 0,04982527 ! negative regulation of T cell activation GO:0050868 41 20 1,000 8,219E-03 0,04970194 ! nucleoside metabolic process GO:0009116 91 62 2,000 8,972E-03 0,05411706 ! lipid phosphorylation GO:0046834 43 21 1,000 9,044E-03 0,05441746 ! ovarian follicle development GO:0001541 39 21 1,000 9,044E-03 0,05428376 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 9,044E-03 0,05415071 ! diencephalon development GO:0021536 36 21 1,000 9,044E-03 0,05401831 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 9,044E-03 0,05388656 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 9,044E-03 0,05375545 ! skeletal system morphogenesis GO:0048705 118 63 2,000 9,373E-03 0,05557894 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 9,903E-03 0,05858035 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 1,000 9,903E-03 0,05843885 ! microtubule-based transport GO:0010970 59 22 1,000 9,903E-03 0,05829803 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 9,903E-03 0,05815789 ! vacuolar transport GO:0007034 41 22 1,000 9,903E-03 0,05801842 ! apoptotic nuclear changes GO:0030262 34 22 1,000 9,903E-03 0,05787962 ! ureteric bud development GO:0001657 50 22 1,000 9,903E-03 0,05774149 ! positive regulation of locomotion GO:0040017 44 22 1,000 9,903E-03 0,05760401 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of intracellular transport GO:0032388 42 22 1,000 9,903E-03 0,05746718 ! positive regulation of B cell activation GO:0050871 42 22 1,000 9,903E-03 0,057331 ! response to cytokine stimulus GO:0034097 69 22 1,000 9,903E-03 0,05719547 ! activation of JUN kinase activity GO:0007257 47 22 1,000 9,903E-03 0,05706057 ! gut development GO:0048565 44 22 1,000 9,903E-03 0,05692631 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 9,903E-03 0,05679268 ! lymphocyte mediated immunity GO:0002449 122 65 2,000 0,01020742 0,05839984 ! ear development GO:0043583 114 66 2,000 0,01064022 0,0607338 ! positive regulation of DNA replication GO:0045740 44 23 1,000 0,01079775 0,06148927 ! regulation of chemotaxis GO:0050920 45 23 1,000 0,01079775 0,06134627 ! regeneration GO:0031099 42 23 1,000 0,01079775 0,06120394 ! axis specification GO:0009798 43 23 1,000 0,01079775 0,06106226 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 0,01079775 0,06092124 GO:0010810|regulation of cell-substrate adhesion, ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 0,01079775 0,06078087 ! vesicle targeting GO:0006903 49 23 1,000 0,01079775 0,06064114 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 0,01079775 0,06050206 ! DNA modification GO:0006304 36 23 1,000 0,01079775 0,06036361 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 0,01079775 0,06022579 ! activation of MAPK activity GO:0000187 124 67 2,000 0,01108352 0,06167889 ! regulation of cellular response to stress GO:0080135 142 68 2,000 0,01153735 0,0640585 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 0,01172651 0,06496117 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 0,01172651 0,0648142 ! protein amino acid O-linked glycosylation GO:0006493 45 24 1,000 0,01172651 0,06466789 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 0,01172651 0,06452224 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 0,01172651 0,06437725 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 0,01172651 0,0642329 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! sex determination GO:0007530 48 24 1,000 0,01172651 0,0640892 ! regulation of viral reproduction GO:0050792 41 24 1,000 0,01172651 0,06394615 ! pallium development GO:0021543 56 24 1,000 0,01172651 0,06380373 ! oogenesis GO:0048477 44 24 1,000 0,01172651 0,06366194 ! synaptic vesicle transport GO:0048489 52 24 1,000 0,01172651 0,06352079 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 0,01172651 0,06338025 ! aromatic amino acid family metabolic process GO:0009072 37 24 1,000 0,01172651 0,06324034 ! negative regulation of protein kinase activity GO:0006469 144 69 2,000 0,01200175 0,06458213 ! homeostasis of number of cells GO:0048872 131 69 2,000 0,01200175 0,06444019 ! developmental maturation GO:0021700 128 69 2,000 0,01200175 0,06429887 ! negative regulation of kinase activity GO:0033673 145 70 2,000 0,01247677 0,0666975 ! germ cell development GO:0007281 133 70 2,000 0,01247677 0,06655187 ! protein maturation by peptide bond cleavage GO:0051605 118 70 2,000 0,01247677 0,06640688 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 0,01268906 0,06738994 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 0,01268906 0,06724376 ! vasculogenesis GO:0001570 49 25 1,000 0,01268906 0,06709821 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 0,01268906 0,06695329 ! negative regulation of DNA replication GO:0008156 45 25 1,000 0,01268906 0,06680899 ! regulation of behavior GO:0050795 48 25 1,000 0,01268906 0,06666532 ! interaction with host GO:0051701 66 25 1,000 0,01268906 0,06652226 ! lymphocyte proliferation GO:0046651 55 25 1,000 0,01268906 0,06637981 ! cell cycle checkpoint GO:0000075 145 71 2,000 0,01296244 0,06766506 ! carbohydrate transport GO:0008643 114 72 2,000 0,01345879 0,07010625 ! B cell activation GO:0042113 179 72 2,000 0,01345879 0,06995709 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 0,01345879 0,06980856 ! macromolecular complex disassembly GO:0032984 54 26 1,000 0,01368488 0,07083085 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 0,01368488 0,0706811 ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,01368488 0,07053198 ! digestive system process GO:0022600 49 26 1,000 0,01368488 0,0703835 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 0,01368488 0,07023563 ! negative regulation of cell development GO:0010721 83 26 1,000 0,01368488 0,07008839 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,01368488 0,06994176 GO:0045840|positive regulation of mitosis, ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 0,01368488 0,06979574 ! acute inflammatory response GO:0002526 118 74 2,000 0,01448366 0,07371581 ! regulation of caspase activity GO:0043281 136 74 2,000 0,01448366 0,07356255 ! negative regulation of transferase activity GO:0051348 155 74 2,000 0,01448366 0,07340993 ! organelle localization GO:0051640 155 74 2,000 0,01448366 0,07325795 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 1,000 0,01471348 0,07426657 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 0,01471348 0,07411345 ! response to toxin GO:0009636 49 27 1,000 0,01471348 0,07396095 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01471348 0,07380908 ! leukocyte proliferation GO:0070661 59 27 1,000 0,01471348 0,07365783 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 0,01471348 0,0735072 ! reproductive structure development GO:0048608 131 75 2,000 0,01501224 0,07484672 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,01501224 0,07469428 ! leukocyte mediated immunity GO:0002443 136 75 2,000 0,01501224 0,07454246 ! axon guidance GO:0007411 162 75 2,000 0,01501224 0,07439126 ! lymphocyte differentiation GO:0030098 193 76 2,000 0,0155516 0,07690801 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01577436 0,07785202 ! dendrite development GO:0016358 67 28 1,000 0,01577436 0,07769506 ! negative regulation of protein modification process GO:0031400 66 28 1,000 0,01577436 0,07753873 ! base-excision repair GO:0006284 41 28 1,000 0,01577436 0,07738303 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 0,01577436 0,07722796 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 0,01577436 0,0770735 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 0,01610178 0,07851625 ! regulation of catabolic process GO:0009894 173 77 2,000 0,01610178 0,07835985 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01686703 0,08192079 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01686703 0,08175825 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01686703 0,08159635 ! somitogenesis GO:0001756 52 29 1,000 0,01686703 0,08143509 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01686703 0,08127447 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 0,01723465 0,08288239 ! protein oligomerization GO:0051259 149 79 2,000 0,01723465 0,08271955 ! regulation of synaptic transmission GO:0050804 159 79 2,000 0,01723465 0,08255736 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01781738 0,08518172 ! myofibril assembly GO:0030239 50 30 1,000 0,01799102 0,08584386 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 1,000 0,01799102 0,08567653 GO:0002764|immune response-regulating signal transduction, ! neurotransmitter secretion GO:0007269 55 30 1,000 0,01799102 0,08550984 ! tissue homeostasis GO:0001894 50 30 1,000 0,01799102 0,0853438 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 1,000 0,01799102 0,08517841 ! regulation of peptidase activity GO:0052547 150 82 2,000 0,01901549 0,08985462 ! protein import into nucleus GO:0006606 174 82 2,000 0,01901549 0,08968116 ! ovulation cycle process GO:0022602 55 31 1,000 0,01914584 0,09012195 ! peptide transport GO:0015833 60 31 1,000 0,01914584 0,08994864 ! male gonad development GO:0008584 56 31 1,000 0,01914584 0,08977599 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01914584 0,08960401 ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 0,01914584 0,08943268 ! nuclear import GO:0051170 177 83 2,000 0,01963089 0,09152341 ! response to metal ion GO:0010038 158 84 2,000 0,0202572 0,09426351 ! T cell activation GO:0042110 189 84 2,000 0,0202572 0,09408431 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 1,000 0,02033103 0,094248 ! metanephros development GO:0001656 81 32 1,000 0,02033103 0,0940695 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,02033103 0,09389168 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,02033103 0,09371453 ! muscle cell development GO:0055001 52 32 1,000 0,02033103 0,09353804 ! ovulation cycle GO:0042698 57 32 1,000 0,02033103 0,09336222 ! hindbrain development GO:0030902 65 32 1,000 0,02033103 0,09318705 ! regulation of transmission of nerve impulse GO:0051969 167 85 2,000 0,02089443 0,09559006 ! regulation of pH GO:0006885 56 33 1,000 0,02154611 0,09838718 ! cholesterol homeostasis GO:0042632 60 33 1,000 0,02154611 0,09820362 GO:0055092|sterol homeostasis, ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,02154611 0,09802074 ! triglyceride metabolic process GO:0006641 46 33 1,000 0,02154611 0,09783855 ! regulation of axonogenesis GO:0050770 86 33 1,000 0,02154611 0,09765703 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,02154611 0,09747618 ! establishment of vesicle localization GO:0051650 67 33 1,000 0,02154611 0,09729601 ! neuropeptide signaling pathway GO:0007218 125 87 2,000 0,02220164 0,10007125 ! regulation of protein transport GO:0051223 165 87 2,000 0,02220164 0,09988696 GO:0070201|regulation of establishment of protein localization, ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,02279062 0,10234831 ! glial cell differentiation GO:0010001 67 34 1,000 0,02279062 0,10216052 ! post-embryonic development GO:0009791 76 34 1,000 0,02279062 0,10197341 ! cholesterol transport GO:0030301 62 34 1,000 0,02279062 0,10178699 ! adult locomotory behavior GO:0008344 62 34 1,000 0,02279062 0,10160124 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,02279062 0,10141618 ! regulation of DNA binding GO:0051101 167 89 2,000 0,02355255 0,10461613 ! tube morphogenesis GO:0035239 194 89 2,000 0,02355255 0,10442627 ! protein localization in nucleus GO:0034504 192 89 2,000 0,02355255 0,10423709 ! DNA damage checkpoint GO:0000077 78 35 1,000 0,0240641 0,10630851 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,0240641 0,10611662 ! telencephalon development GO:0021537 81 35 1,000 0,0240641 0,10592542 ! sterol transport GO:0015918 63 35 1,000 0,0240641 0,10573491 ! placenta development GO:0001890 53 35 1,000 0,0240641 0,10554508 ! vesicle localization GO:0051648 70 35 1,000 0,0240641 0,10535593 ! response to inorganic substance GO:0010035 173 90 2,000 0,02424438 0,10595531 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,02536611 0,11065966 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,02536611 0,11046241 ! positive regulation of cell development GO:0010720 85 36 1,000 0,02536611 0,11026586 ! regulation of proteolysis GO:0030162 77 36 1,000 0,02536611 0,11007 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,02536611 0,10987484 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,02669619 0,1154315 ! sister chromatid segregation GO:0000819 65 37 1,000 0,02669619 0,11522756 ! actomyosin structure organization GO:0031032 68 37 1,000 0,02669619 0,11502433 ! tissue remodeling GO:0048771 78 37 1,000 0,02669619 0,11482183 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,02669619 0,11462003 ! female gonad development GO:0008585 71 37 1,000 0,02669619 0,11441894 ! negative regulation of cell activation GO:0050866 69 37 1,000 0,02669619 0,11421856 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 0,02786709 0,11901975 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,0280539 0,11960852 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 0,0280539 0,11940014 ! neutral lipid metabolic process GO:0006638 54 38 1,000 0,0280539 0,11919249 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,0280539 0,11898556 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,0280539 0,11877935 ! regulation of protein stability GO:0031647 77 38 1,000 0,0280539 0,11857385 ! pigment metabolic process GO:0042440 87 38 1,000 0,0280539 0,11836905 ! response to protein stimulus GO:0051789 158 96 2,000 0,02862428 0,12056743 ! regulation of neuron projection development GO:0010975 102 39 1,000 0,0294388 0,12378485 ! negative regulation of binding GO:0051100 71 39 1,000 0,0294388 0,12357216 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,0294388 0,1233602 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,0294388 0,12314896 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,0294388 0,12293845 ! leukocyte differentiation GO:0002521 232 98 2,000 0,0301712 0,12578197 ! mammary gland development GO:0030879 93 40 1,000 0,03085046 0,12839468 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,03085046 0,12817632 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 1,000 0,03085046 0,1279587 ! lipid homeostasis GO:0055088 75 40 1,000 0,03085046 0,12774182 ! glycerol ether metabolic process GO:0006662 57 40 1,000 0,03085046 0,12752568 ! Rho protein signal transduction GO:0007266 88 40 1,000 0,03085046 0,12731026 ! gliogenesis GO:0042063 91 41 1,000 0,03228845 0,13301969 ! feeding behavior GO:0007631 69 41 1,000 0,03228845 0,13279575 ! mesenchymal cell development GO:0014031 94 41 1,000 0,03228845 0,13257256 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,03228845 0,13235012 ! maintenance of protein location GO:0045185 95 41 1,000 0,03228845 0,13212843 ! ear morphogenesis GO:0042471 64 42 1,000 0,03375233 0,13788788 ! organic ether metabolic process GO:0018904 59 42 1,000 0,03375233 0,13765768 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,03375233 0,13742825 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,03375233 0,13719959 ! cytokinesis GO:0000910 84 42 1,000 0,03375233 0,13697168 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,03385751 0,13717065 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,03385751 0,13694355 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03385751 0,1367172 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,03385751 0,13649159 ! neuron fate determination GO:0048664 7 5 0,000 0,03385751 0,13626673 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03385751 0,1360426 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03385751 0,13581922 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,03385751 0,13559656 ! polyol transport GO:0015791 12 5 0,000 0,03385751 0,13537464 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03385751 0,13515344 ! response to superoxide GO:0000303 10 5 0,000 0,03385751 0,13493296 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03385751 0,1347132 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,03385751 0,13449415 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03385751 0,13427582 ! female meiosis GO:0007143 10 5 0,000 0,03385751 0,13405819 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,03385751 0,13384127 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03385751 0,13362505 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03385751 0,13340952 ! cobalt ion transport GO:0006824 11 5 0,000 0,03385751 0,13319469 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03385751 0,13298055 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03385751 0,1327671 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03385751 0,13255433 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,03385751 0,13234225 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03385751 0,13213084 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03385751 0,1319201 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03385751 0,13171004 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03385751 0,13150064 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,03385751 0,13129191 ! transposition GO:0032196 9 5 0,000 0,03385751 0,13108384 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,03385751 0,13087643 ! negative chemotaxis GO:0050919 16 5 0,000 0,03385751 0,13066967 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03385751 0,13046357 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03385751 0,13025812 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03385751 0,13005331 ! behavioral response to pain GO:0048266 10 5 0,000 0,03385751 0,12984914 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03385751 0,12964562 ! Notch receptor processing GO:0007220 11 5 0,000 0,03385751 0,12944273 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03385751 0,12924047 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03385751 0,12903885 ! micturition GO:0060073 9 5 0,000 0,03385751 0,12883786 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03385751 0,12863749 ! copulation GO:0007620 9 5 0,000 0,03385751 0,12843774 ! glial cell fate commitment GO:0021781 14 5 0,000 0,03385751 0,12823861 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03385751 0,1280401 ! bioluminescence GO:0008218 9 5 0,000 0,03385751 0,1278422 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03385751 0,12764491 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03385751 0,12744823 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03385751 0,12725216 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03385751 0,12705669 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03385751 0,12686182 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03385751 0,12666754 ! grooming behavior GO:0007625 6 5 0,000 0,03385751 0,12647386 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03385751 0,12628077 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03385751 0,12608827 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03385751 0,12589635 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03385751 0,12570502 ! response to protozoan GO:0001562 13 5 0,000 0,03385751 0,12551427 ! lymph vessel development GO:0001945 10 5 0,000 0,03385751 0,1253241 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03385751 0,1251345 ! endochondral ossification GO:0001958 17 5 0,000 0,03385751 0,12494547 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03385751 0,12475702 ! single strand break repair GO:0000012 8 5 0,000 0,03385751 0,12456913 ! parathyroid gland development GO:0060017 14 5 0,000 0,03385751 0,12438181 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03385751 0,12419505 ! cytokine secretion GO:0050663 15 5 0,000 0,03385751 0,12400885 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03385751 0,12382321 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03385751 0,12363812 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,03385751 0,12345359 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03385751 0,1232696 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03385751 0,12308617 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,03385751 0,12290327 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03385751 0,12272093 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03385751 0,12253912 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03385751 0,12235785 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,03385751 0,12217711 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03385751 0,12199691 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03385751 0,12181724 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03385751 0,12163809 ! valine metabolic process GO:0006573 12 5 0,000 0,03385751 0,12145948 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03385751 0,12128138 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,03385751 0,12110381 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03385751 0,12092676 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03385751 0,12075022 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03385751 0,1205742 ! polyol catabolic process GO:0046174 9 5 0,000 0,03385751 0,1203987 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03385751 0,1202237 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03385751 0,12004921 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03385751 0,11987522 ! muscle cell migration GO:0014812 8 5 0,000 0,03385751 0,11970174 ! mitochondrial fission GO:0000266 8 5 0,000 0,03385751 0,11952876 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03385751 0,11935628 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,03385751 0,1191843 ! mRNA transcription GO:0009299 10 5 0,000 0,03385751 0,11901281 ! nerve growth factor processing GO:0032455 9 5 0,000 0,03385751 0,11884182 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,03385751 0,11867131 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03385751 0,11850129 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03385751 0,11833176 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03385751 0,11816272 ! monocyte activation GO:0042117 10 5 0,000 0,03385751 0,11799416 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03385751 0,11782607 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03385751 0,11765847 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,03385751 0,11749134 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03385751 0,11732469 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03385751 0,1171585 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03385751 0,11699279 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,03385751 0,11682755 ! forebrain neuron development GO:0021884 13 5 0,000 0,03385751 0,11666277 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,03385751 0,11649846 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03385751 0,1163346 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03385751 0,11617121 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03385751 0,11600828 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,03385751 0,1158458 ! lipid glycosylation GO:0030259 7 5 0,000 0,03385751 0,11568378 ! nucleobase transport GO:0015851 6 5 0,000 0,03385751 0,11552221 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03385751 0,11536109 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03385751 0,11520042 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,03385751 0,1150402 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03385751 0,11488042 ! basic amino acid transport GO:0015802 12 5 0,000 0,03385751 0,11472109 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,03385751 0,11456219 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03385751 0,11440374 ! actin nucleation GO:0045010 11 5 0,000 0,03385751 0,11424572 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03385751 0,11408814 ! depurination GO:0045007 5 5 0,000 0,03385751 0,113931 ! depyrimidination GO:0045008 10 5 0,000 0,03385751 0,11377428 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03385751 0,113618 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,03385751 0,11346214 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03385751 0,11330672 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03385751 0,11315171 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03385751 0,11299714 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03385751 0,11284298 ! activated T cell proliferation GO:0050798 16 5 0,000 0,03385751 0,11268924 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03385751 0,11253592 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03385751 0,11238302 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03385751 0,11223053 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03385751 0,11207846 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03385751 0,1119268 ! response to arsenic GO:0046685 11 5 0,000 0,03385751 0,11177555 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,03385751 0,1116247 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03385751 0,11147426 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,03385751 0,11132423 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03385751 0,1111746 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03385751 0,11102537 ! response to cadmium ion GO:0046686 7 5 0,000 0,03385751 0,11087655 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03385751 0,11072812 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03385751 0,11058009 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03385751 0,11043245 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03385751 0,1102852 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03385751 0,11013835 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03385751 0,10999189 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03385751 0,10984582 ! decidualization GO:0046697 11 5 0,000 0,03385751 0,10970014 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03385751 0,10955484 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03385751 0,10940993 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03385751 0,10926539 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03385751 0,10912124 ! embryonic cleavage GO:0040016 6 5 0,000 0,03385751 0,10897748 ! peroxisome fission GO:0016559 5 5 0,000 0,03385751 0,10883408 ! histone demethylation GO:0016577 13 5 0,000 0,03385751 0,10869107 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03385751 0,10854843 ! mitotic recombination GO:0006312 9 5 0,000 0,03385751 0,10840616 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03385751 0,10826427 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03385751 0,10812275 ! metaphase plate congression GO:0051310 7 5 0,000 0,03385751 0,1079816 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03385751 0,10784081 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03385751 0,1077004 ! enteric nervous system development GO:0048484 8 5 0,000 0,03385751 0,10756034 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03385751 0,10742065 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03385751 0,10728133 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,03385751 0,10714236 ! muscle cell proliferation GO:0033002 12 5 0,000 0,03385751 0,10700376 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03385751 0,10686551 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,03385751 0,10672762 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03385751 0,10659008 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03385751 0,1064529 ! metaphase GO:0051323 11 5 0,000 0,03385751 0,10631607 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03385751 0,10617959 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03385751 0,10604347 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03385751 0,10590769 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03385751 0,10577226 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03385751 0,10563717 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03385751 0,10550243 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03385751 0,10536803 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03385751 0,10523397 ! response to redox state GO:0051775 6 5 0,000 0,03385751 0,10510026 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03385751 0,10496688 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03385751 0,10483384 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03385751 0,10470114 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03385751 0,10456878 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03385751 0,10443675 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03385751 0,10430505 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03385751 0,10417368 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03385751 0,10404265 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03385751 0,10391194 ! striatum development GO:0021756 14 5 0,000 0,03385751 0,10378156 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,03385751 0,10365151 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03385751 0,10352178 ! glial cell migration GO:0008347 10 5 0,000 0,03385751 0,10339238 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03385751 0,1032633 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03385751 0,10313454 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03385751 0,10300611 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03385751 0,10287799 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03385751 0,10275019 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03385751 0,10262271 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03385751 0,10249554 ! neuroprotection GO:0043526 8 5 0,000 0,03385751 0,10236869 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03385751 0,10224216 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03385751 0,10211593 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,03385751 0,10199002 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03385751 0,10186441 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03385751 0,10173912 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03385751 0,10161413 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,03385751 0,10148945 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,03385751 0,10136508 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03385751 0,10124101 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03385751 0,10111724 ! spindle assembly GO:0051225 6 5 0,000 0,03385751 0,10099378 ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03385751 0,10087061 ! protein palmitoylation GO:0018345 12 5 0,000 0,03385751 0,10074775 ! drug metabolic process GO:0017144 7 5 0,000 0,03385751 0,10062519 ! stem cell division GO:0017145 11 5 0,000 0,03385751 0,10050292 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,03385751 0,10038095 ! organ regeneration GO:0031100 7 5 0,000 0,03385751 0,10025928 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03385751 0,1001379 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03385751 0,10001681 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,0352417 0,10398005 GO:0090047|positive regulation of transcription regulator activity, ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,0352417 0,10385463 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 1,000 0,0352417 0,1037295 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,0352417 0,10360468 ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,0352417 0,10348015 ! segmentation GO:0035282 78 43 1,000 0,0352417 0,10335592 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,03675614 0,10766817 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 0,03675614 0,10753923 ! double-strand break repair GO:0006302 85 44 1,000 0,03675614 0,10741059 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,03829524 0,11177451 ! biopolymer methylation GO:0043414 91 45 1,000 0,03829524 0,11164112 ! female gamete generation GO:0007292 71 45 1,000 0,03829524 0,11150806 ! polyol metabolic process GO:0019751 77 45 1,000 0,03829524 0,11137531 ! maintenance of location in cell GO:0051651 101 45 1,000 0,03829524 0,11124288 ! negative regulation of cell migration GO:0030336 122 46 1,000 0,03985858 0,11564668 ! polysaccharide biosynthetic process GO:0000271 79 46 1,000 0,03985858 0,1155095 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,03985858 0,11537264 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04049075 0,1170638 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04049075 0,11692543 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,04049075 0,11678738 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,04049075 0,11664966 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04049075 0,11651226 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,04049075 0,11637519 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,04049075 0,11623844 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04049075 0,11610201 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,04049075 0,1159659 ! response to oxygen radical GO:0000305 11 6 0,000 0,04049075 0,11583011 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,04049075 0,11569463 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,04049075 0,11555948 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,04049075 0,11542464 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,04049075 0,11529011 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04049075 0,11515589 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,04049075 0,11502199 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,04049075 0,1148884 ! forebrain regionalization GO:0021871 9 6 0,000 0,04049075 0,11475512 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04049075 0,11462215 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04049075 0,11448948 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,04049075 0,11435712 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04049075 0,11422507 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,04049075 0,11409332 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04049075 0,11396188 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,04049075 0,11383074 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,04049075 0,1136999 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04049075 0,11356936 ! malate metabolic process GO:0006108 13 6 0,000 0,04049075 0,11343912 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,04049075 0,11330918 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,04049075 0,11317953 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,04049075 0,11305019 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,04049075 0,11292113 ! protein refolding GO:0042026 15 6 0,000 0,04049075 0,11279237 ! opsonization GO:0008228 8 6 0,000 0,04049075 0,11266391 ! mating behavior GO:0007617 7 6 0,000 0,04049075 0,11253574 ! erythrocyte maturation GO:0043249 8 6 0,000 0,04049075 0,11240786 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,04049075 0,11228026 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,04049075 0,11215296 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,04049075 0,11202595 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,04049075 0,11189922 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04049075 0,11177278 ! response to interferon-gamma GO:0034341 16 6 0,000 0,04049075 0,11164663 ! toxin metabolic process GO:0009404 11 6 0,000 0,04049075 0,11152076 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04049075 0,11139517 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,04049075 0,11126987 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,04049075 0,11114485 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,04049075 0,1110201 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,04049075 0,11089564 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,04049075 0,11077146 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,04049075 0,11064755 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04049075 0,11052392 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,04049075 0,11040057 ! thymic T cell selection GO:0045061 16 6 0,000 0,04049075 0,11027749 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,04049075 0,11015469 ! protein lipoylation GO:0009249 10 6 0,000 0,04049075 0,11003216 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,04049075 0,1099099 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,04049075 0,10978792 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04049075 0,1096662 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,04049075 0,10954475 ! glutamate catabolic process GO:0006538 12 6 0,000 0,04049075 0,10942358 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,04049075 0,10930267 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04049075 0,10918202 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,04049075 0,10906165 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04049075 0,10894153 ! hyperosmotic response GO:0006972 10 6 0,000 0,04049075 0,10882169 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,04049075 0,1087021 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,04049075 0,10858278 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,04049075 0,10846372 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,04049075 0,10834492 ! urea metabolic process GO:0019627 7 6 0,000 0,04049075 0,10822638 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04049075 0,1081081 ! neutrophil activation GO:0042119 7 6 0,000 0,04049075 0,10799008 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04049075 0,10787231 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,04049075 0,10775481 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04049075 0,10763755 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,04049075 0,10752056 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,04049075 0,10740381 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04049075 0,10728732 ! neuron apoptosis GO:0051402 15 6 0,000 0,04049075 0,10717109 ! T cell mediated immunity GO:0002456 17 6 0,000 0,04049075 0,1070551 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04049075 0,10693936 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,04049075 0,10682388 ! carnitine transport GO:0015879 10 6 0,000 0,04049075 0,10670864 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04049075 0,10659366 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,04049075 0,10647892 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,04049075 0,10636442 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,04049075 0,10625017 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,04049075 0,10613617 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04049075 0,10602241 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,04049075 0,1059089 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,04049075 0,10579563 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,04049075 0,1056826 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,04049075 0,10556981 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,04049075 0,10545726 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,04049075 0,10534495 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04049075 0,10523289 ! interaction with symbiont GO:0051702 14 6 0,000 0,04049075 0,10512105 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04049075 0,10500946 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,04049075 0,1048981 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,04049075 0,10478698 ! response to copper ion GO:0046688 10 6 0,000 0,04049075 0,1046761 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,04049075 0,10456545 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,04049075 0,10445503 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04049075 0,10434484 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,04049075 0,10423489 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,04049075 0,10412517 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,04049075 0,10401568 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04049075 0,10390642 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,04049075 0,10379739 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04049075 0,10368859 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,04049075 0,10358001 ! response to pheromone GO:0019236 6 6 0,000 0,04049075 0,10347167 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,04049075 0,10336354 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,04049075 0,10325565 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,04049075 0,10314798 ! subpallium development GO:0021544 15 6 0,000 0,04049075 0,10304053 ! neural tube patterning GO:0021532 8 6 0,000 0,04049075 0,10293331 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,04049075 0,10282631 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,04049075 0,10271954 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04049075 0,10261298 ! G2 phase GO:0051319 16 6 0,000 0,04049075 0,10250665 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,04049075 0,10240053 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,04049075 0,10229464 ! oxygen homeostasis GO:0032364 10 6 0,000 0,04049075 0,10218896 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04049075 0,1020835 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,04049075 0,10197826 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04049075 0,10187324 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,04049075 0,10176843 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04049075 0,10166384 ! receptor internalization GO:0031623 11 6 0,000 0,04049075 0,10155946 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,04049075 0,10145529 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,04049075 0,10135134 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,04049075 0,10124761 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04049075 0,10114408 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,04049075 0,10104077 ! protein deubiquitination GO:0016579 16 6 0,000 0,04049075 0,10093767 ! protein destabilization GO:0031648 9 6 0,000 0,04049075 0,10083477 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,04049075 0,10073209 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04049075 0,10062962 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,04049075 0,10052735 ! regulation of viral transcription GO:0046782 11 6 0,000 0,04049075 0,10042529 ! progesterone metabolic process GO:0042448 12 6 0,000 0,04049075 0,10032344 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,04049075 0,1002218 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,04049075 0,10012036 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,04049075 0,10001912 ! determination of adult lifespan GO:0008340 17 6 0,000 0,04049075 0,09991809 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,04049075 0,09981727 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04049075 0,09971665 ! neural plate development GO:0001840 9 6 0,000 0,04049075 0,09961623 ! catecholamine transport GO:0051937 9 6 0,000 0,04049075 0,09951601 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,04049075 0,09941599 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04049075 0,09931618 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,04049075 0,09921656 ! maternal placenta development GO:0001893 12 6 0,000 0,04049075 0,09911715 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,04049075 0,09901793 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04049075 0,09891891 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,04049075 0,09882009 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,04049075 0,09872147 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,04049075 0,09862304 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,04049075 0,09852481 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,04049075 0,09842678 GO:0055081|anion homeostasis, ! endosome transport GO:0016197 127 48 1,000 0,0430564 0,10455944 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,0430564 0,1044556 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,0430564 0,10435198 ! male sex differentiation GO:0046661 93 48 1,000 0,0430564 0,10424856 ! methylation GO:0032259 97 48 1,000 0,0430564 0,10414534 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,04469009 0,10799001 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,04469009 0,1078833 ! JNK cascade GO:0007254 106 49 1,000 0,04469009 0,1077768 ! endocrine system development GO:0035270 109 50 1,000 0,04634645 0,11166112 ! regulation of ossification GO:0030278 123 50 1,000 0,04634645 0,11155111 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,04634645 0,11144132 ! tRNA transcription GO:0009304 17 7 0,000 0,04707864 0,11309058 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04707864 0,11297948 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,04707864 0,11286861 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04707864 0,11275796 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,04707864 0,11264752 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04707864 0,11253729 ! sleep GO:0030431 16 7 0,000 0,04707864 0,11242729 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04707864 0,1123175 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04707864 0,11220792 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04707864 0,11209855 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04707864 0,1119894 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04707864 0,11188046 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04707864 0,11177174 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04707864 0,11166322 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04707864 0,11155491 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04707864 0,11144682 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04707864 0,11133893 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04707864 0,11123125 ! glycolipid transport GO:0046836 11 7 0,000 0,04707864 0,11112378 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04707864 0,11101652 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04707864 0,11090947 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04707864 0,11080262 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04707864 0,11069597 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04707864 0,11058953 ! pericardium development GO:0060039 16 7 0,000 0,04707864 0,1104833 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04707864 0,11037727 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04707864 0,11027144 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,04707864 0,11016582 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04707864 0,1100604 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04707864 0,10995518 ! lipoprotein transport GO:0042953 14 7 0,000 0,04707864 0,10985016 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04707864 0,10974534 ! rhythmic behavior GO:0007622 17 7 0,000 0,04707864 0,10964072 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04707864 0,1095363 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04707864 0,10943208 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04707864 0,10932806 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04707864 0,10922423 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04707864 0,1091206 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04707864 0,10901717 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04707864 0,10891394 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04707864 0,10881089 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04707864 0,10870805 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04707864 0,1086054 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04707864 0,10850294 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04707864 0,10840067 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04707864 0,1082986 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04707864 0,10819672 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04707864 0,10809503 ! spinal cord patterning GO:0021511 14 7 0,000 0,04707864 0,10799354 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04707864 0,10789223 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04707864 0,10779111 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04707864 0,10769018 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04707864 0,10758944 ! adrenal gland development GO:0030325 17 7 0,000 0,04707864 0,10748889 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04707864 0,10738853 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04707864 0,10728835 ! ovulation GO:0030728 10 7 0,000 0,04707864 0,10718836 ! adenohypophysis development GO:0021984 11 7 0,000 0,04707864 0,10708856 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04707864 0,10698894 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04707864 0,10688951 ! microtubule nucleation GO:0007020 21 7 0,000 0,04707864 0,10679027 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04707864 0,1066912 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04707864 0,10659232 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04707864 0,10649363 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04707864 0,10639511 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04707864 0,10629678 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04707864 0,10619863 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04707864 0,10610066 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04707864 0,10600287 ! galactose metabolic process GO:0006012 13 7 0,000 0,04707864 0,10590526 ! vesicle fusion GO:0006906 20 7 0,000 0,04707864 0,10580783 ! response to dietary excess GO:0002021 8 7 0,000 0,04707864 0,10571058 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04707864 0,10561351 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04707864 0,10551662 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,04707864 0,1054199 ! nucleoside transport GO:0015858 11 7 0,000 0,04707864 0,10532337 ! nucleoside salvage GO:0043174 11 7 0,000 0,04707864 0,105227 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04707864 0,10513082 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04707864 0,10503481 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04707864 0,10493897 ! parturition GO:0007567 16 7 0,000 0,04707864 0,10484331 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,04707864 0,10474783 ! rRNA modification GO:0000154 14 7 0,000 0,04707864 0,10465252 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04707864 0,10455738 ! spindle checkpoint GO:0031577 16 7 0,000 0,04707864 0,10446241 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,04707864 0,10436762 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04707864 0,104273 ! monocyte differentiation GO:0030224 16 7 0,000 0,04707864 0,10417855 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04707864 0,10408427 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04707864 0,10399016 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,04707864 0,10389622 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04707864 0,10380245 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04707864 0,10370885 ! fibrinolysis GO:0042730 11 7 0,000 0,04707864 0,10361542 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,04707864 0,10352216 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04707864 0,10342906 ! eating behavior GO:0042755 8 7 0,000 0,04707864 0,10333613 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04707864 0,10324337 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04707864 0,10315078 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04707864 0,10305835 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04707864 0,10296608 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,04707864 0,10287399 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04707864 0,10278205 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,04707864 0,10269028 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04707864 0,10259868 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04707864 0,10250723 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04707864 0,10241595 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04707864 0,10232484 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04707864 0,10223388 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04707864 0,10214309 ! histone ubiquitination GO:0016574 9 7 0,000 0,04707864 0,10205245 ! regulation of meiosis GO:0040020 12 7 0,000 0,04707864 0,10196198 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04707864 0,10187167 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04707864 0,10178152 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04707864 0,10169153 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04707864 0,10160169 ! transcription termination GO:0006353 14 7 0,000 0,04707864 0,10151202 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04707864 0,1014225 ! anaphase GO:0051322 18 7 0,000 0,04707864 0,10133314 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04707864 0,10124394 ! axonal fasciculation GO:0007413 19 7 0,000 0,04707864 0,10115489 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04707864 0,10106601 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04707864 0,10097727 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04707864 0,1008887 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04707864 0,10080028 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04707864 0,10071201 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04707864 0,1006239 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04707864 0,10053594 ! antibiotic transport GO:0042891 9 7 0,000 0,04707864 0,10044814 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04707864 0,10036048 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04707864 0,10027299 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04707864 0,10018564 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04707864 0,10009845 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04707864 0,1000114 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04707864 0,09992451 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04707864 0,09983777 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04707864 0,09975118 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04707864 0,09966474 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04707864 0,09957845 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04707864 0,09949231 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04707864 0,09940632 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04707864 0,09932048 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04707864 0,09923478 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04707864 0,09914924 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04707864 0,09906384 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04707864 0,09897858 ! muscle adaptation GO:0043500 13 7 0,000 0,04707864 0,09889348 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04707864 0,09880852 ! retina homeostasis GO:0001895 12 7 0,000 0,04707864 0,0987237 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04707864 0,09863904 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04707864 0,09855451 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04707864 0,09847013 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04707864 0,0983859 ! regulation of cell projection organization GO:0031344 135 51 1,000 0,04802509 0,10027802 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,04802509 0,10019239 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,04802509 0,1001069 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,04802509 0,10002155 ! positive regulation of binding GO:0051099 88 52 1,000 0,04972562 0,10347503 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,04972562 0,10338697 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,04972562 0,10329905 ! histone modification GO:0016570 104 52 1,000 0,04972562 0,10321129 ! vesicle organization GO:0016050 127 53 1,000 0,05144767 0,10669497 ! cartilage development GO:0051216 99 53 1,000 0,05144767 0,10660447 ! neuromuscular process GO:0050905 107 54 1,000 0,05319088 0,11012315 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,05319088 0,1100299 ! covalent chromatin modification GO:0016569 115 54 1,000 0,05319088 0,10993682 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,05319088 0,10984389 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,05362148 0,11063958 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,05362148 0,11054622 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,05362148 0,11045301 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,05362148 0,11035996 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,05362148 0,11026706 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05362148 0,11017432 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05362148 0,11008174 ! male meiosis GO:0007140 9 8 0,000 0,05362148 0,10998931 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,05362148 0,10989704 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,05362148 0,10980492 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,05362148 0,10971295 ! meiotic prophase I GO:0007128 14 8 0,000 0,05362148 0,10962114 ! response to zinc ion GO:0010043 12 8 0,000 0,05362148 0,10952949 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,05362148 0,10943798 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05362148 0,10934663 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,05362148 0,10925544 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,05362148 0,10916439 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,05362148 0,10907349 ! signal peptide processing GO:0006465 12 8 0,000 0,05362148 0,10898275 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,05362148 0,10889216 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,05362148 0,10880172 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05362148 0,10871143 ! succinate metabolic process GO:0006105 17 8 0,000 0,05362148 0,10862128 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,05362148 0,10853129 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,05362148 0,10844145 ! estrogen metabolic process GO:0008210 17 8 0,000 0,05362148 0,10835175 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,05362148 0,1082622 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,05362148 0,10817281 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05362148 0,10808355 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05362148 0,10799445 ! reflex GO:0060004 17 8 0,000 0,05362148 0,10790549 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05362148 0,10781668 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,05362148 0,10772802 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05362148 0,1076395 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,05362148 0,10755112 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,05362148 0,10746289 ! histidine catabolic process GO:0006548 10 8 0,000 0,05362148 0,10737481 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05362148 0,10728687 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,05362148 0,10719907 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,05362148 0,10711142 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,05362148 0,10702391 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,05362148 0,10693654 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,05362148 0,10684932 ! macrophage activation GO:0042116 13 8 0,000 0,05362148 0,10676224 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05362148 0,1066753 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,05362148 0,1065885 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,05362148 0,10650184 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,05362148 0,10641533 ! purine salvage GO:0043101 12 8 0,000 0,05362148 0,10632895 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,05362148 0,10624271 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,05362148 0,10615662 ! osteoblast development GO:0002076 17 8 0,000 0,05362148 0,10607066 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,05362148 0,10598484 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,05362148 0,10589917 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,05362148 0,10581362 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05362148 0,10572822 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,05362148 0,10564296 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05362148 0,10555783 ! intermediate filament organization GO:0045109 12 8 0,000 0,05362148 0,10547284 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,05362148 0,10538799 ! cellular extravasation GO:0045123 13 8 0,000 0,05362148 0,10530327 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,05362148 0,10521869 ! response to antibiotic GO:0046677 11 8 0,000 0,05362148 0,10513424 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,05362148 0,10504993 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,05362148 0,10496576 ! DNA topological change GO:0006265 12 8 0,000 0,05362148 0,10488172 ! response to tropane GO:0014073 15 8 0,000 0,05362148 0,10479781 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05362148 0,10471404 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,05362148 0,10463041 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05362148 0,1045469 ! mast cell activation GO:0045576 14 8 0,000 0,05362148 0,10446353 ! multicellular organismal aging GO:0010259 20 8 0,000 0,05362148 0,10438029 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,05362148 0,10429719 ! gas homeostasis GO:0033483 14 8 0,000 0,05362148 0,10421421 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,05362148 0,10413137 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,05362148 0,10404866 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,05362148 0,10396609 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05362148 0,10388364 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05362148 0,10380132 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,05362148 0,10371913 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05362148 0,10363708 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,05362148 0,10355515 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,05362148 0,10347335 ! intracellular lipid transport GO:0032365 16 8 0,000 0,05362148 0,10339169 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05362148 0,10331015 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,05362148 0,10322874 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,05362148 0,10314745 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05362148 0,1030663 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,05362148 0,10298527 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,05362148 0,10290437 ! hormone catabolic process GO:0042447 17 8 0,000 0,05362148 0,1028236 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,05362148 0,10274295 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,05362148 0,10266244 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,05362148 0,10258204 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,05362148 0,10250177 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05362148 0,10242163 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,05362148 0,10234161 ! adult feeding behavior GO:0008343 10 8 0,000 0,05362148 0,10226172 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,05362148 0,10218196 ! ATP catabolic process GO:0006200 11 8 0,000 0,05362148 0,10210231 ! blastocyst growth GO:0001832 19 8 0,000 0,05362148 0,10202279 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05362148 0,1019434 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05362148 0,10186413 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,05362148 0,10178498 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05362148 0,10170595 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,05362148 0,10162705 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,05362148 0,10154827 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,05362148 0,10146961 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,05362148 0,10139107 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,05362148 0,10131266 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,05362148 0,10123436 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05362148 0,10115619 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,05362148 0,10107814 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,05362148 0,10100021 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05362148 0,10092239 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,05362148 0,1008447 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,05362148 0,10076713 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,05362148 0,10068967 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,05362148 0,10061234 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,05362148 0,10053512 ! cell maturation GO:0048469 107 55 1,000 0,05495486 0,10295608 ! negative regulation of cell motion GO:0051271 142 55 1,000 0,05495486 0,10287719 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,05673926 0,10613631 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,05673926 0,1060551 ! heart morphogenesis GO:0003007 105 57 1,000 0,05854371 0,10934426 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,05854371 0,10926073 ! axon extension GO:0048675 16 9 0,000 0,06011957 0,11211612 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,06011957 0,1120306 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,06011957 0,11194521 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06011957 0,11185995 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,06011957 0,11177482 ! reproductive behavior GO:0019098 22 9 0,000 0,06011957 0,11168982 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06011957 0,11160495 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,06011957 0,11152021 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,06011957 0,1114356 ! UTP metabolic process GO:0046051 10 9 0,000 0,06011957 0,11135111 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,06011957 0,11126676 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,06011957 0,11118253 ! artery development GO:0060840 25 9 0,000 0,06011957 0,11109842 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,06011957 0,11101445 ! equilibrioception GO:0050957 20 9 0,000 0,06011957 0,1109306 ! chemosensory behavior GO:0007635 21 9 0,000 0,06011957 0,11084688 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,06011957 0,11076329 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06011957 0,11067982 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,06011957 0,11059647 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,06011957 0,11051326 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,06011957 0,11043016 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,06011957 0,1103472 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06011957 0,11026435 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06011957 0,11018163 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,06011957 0,11009904 ! protein targeting to ER GO:0045047 25 9 0,000 0,06011957 0,11001657 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,06011957 0,10993422 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,06011957 0,10985199 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,06011957 0,10976989 ! glycine catabolic process GO:0006546 15 9 0,000 0,06011957 0,10968791 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,06011957 0,10960606 ! endosome organization GO:0007032 20 9 0,000 0,06011957 0,10952432 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06011957 0,10944271 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,06011957 0,10936122 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06011957 0,10927985 ! mannose metabolic process GO:0006013 13 9 0,000 0,06011957 0,1091986 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,06011957 0,10911747 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,06011957 0,10903646 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,06011957 0,10895558 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,06011957 0,10887481 ! receptor clustering GO:0043113 20 9 0,000 0,06011957 0,10879416 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,06011957 0,10871363 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06011957 0,10863322 ! retinol metabolic process GO:0042572 20 9 0,000 0,06011957 0,10855293 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,06011957 0,10847276 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,06011957 0,10839271 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,06011957 0,10831277 ! macrophage differentiation GO:0030225 15 9 0,000 0,06011957 0,10823295 ! oligodendrocyte development GO:0014003 11 9 0,000 0,06011957 0,10815325 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,06011957 0,10807367 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06011957 0,1079942 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,06011957 0,10791485 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06011957 0,10783562 ! response to amine stimulus GO:0014075 13 9 0,000 0,06011957 0,10775651 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06011957 0,10767751 ! erythrocyte development GO:0048821 17 9 0,000 0,06011957 0,10759862 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06011957 0,10751985 ! renal water homeostasis GO:0003091 15 9 0,000 0,06011957 0,1074412 ! postreplication repair GO:0006301 25 9 0,000 0,06011957 0,10736266 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,06011957 0,10728423 ! icosanoid secretion GO:0032309 15 9 0,000 0,06011957 0,10720592 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06011957 0,10712773 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,06011957 0,10704965 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,06011957 0,10697168 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,06011957 0,10689383 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06011957 0,10681609 ! sterol catabolic process GO:0016127 14 9 0,000 0,06011957 0,10673846 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06011957 0,10666094 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,06011957 0,10658354 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,06011957 0,10650625 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,06011957 0,10642907 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,06011957 0,106352 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,06011957 0,10627505 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,06011957 0,1061982 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,06011957 0,10612147 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,06011957 0,10604485 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,06011957 0,10596834 ! purine base metabolic process GO:0006144 25 9 0,000 0,06011957 0,10589194 ! pigment granule transport GO:0051904 17 9 0,000 0,06011957 0,10581565 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,06011957 0,10573947 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,06011957 0,10566339 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06011957 0,10558743 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,06011957 0,10551158 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,06011957 0,10543583 ! mitochondrion localization GO:0051646 18 9 0,000 0,06011957 0,1053602 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,06036787 0,10571949 ! maintenance of location GO:0051235 124 58 1,000 0,06036787 0,10564376 ! nuclear export GO:0051168 110 59 1,000 0,06221136 0,10879195 ! regulation of neurotransmitter levels GO:0001505 113 60 1,000 0,06407385 0,11196882 ! lipid modification GO:0030258 112 60 1,000 0,06407385 0,11188879 ! DNA catabolic process GO:0006308 94 60 1,000 0,06407385 0,11180887 ! adult behavior GO:0030534 104 60 1,000 0,06407385 0,11172906 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,06657323 0,11600457 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,06657323 0,11592189 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,06657323 0,11583932 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,06657323 0,11575688 ! associative learning GO:0008306 21 10 0,000 0,06657323 0,11567454 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,06657323 0,11559233 ! phosphate transport GO:0006817 24 10 0,000 0,06657323 0,11551023 ! cell volume homeostasis GO:0006884 17 10 0,000 0,06657323 0,11542825 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,06657323 0,11534639 ! CTP metabolic process GO:0046036 11 10 0,000 0,06657323 0,11526464 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,06657323 0,11518301 ! GTP metabolic process GO:0046039 11 10 0,000 0,06657323 0,11510149 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,06657323 0,11502009 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,06657323 0,11493881 ! social behavior GO:0035176 29 10 0,000 0,06657323 0,11485763 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,06657323 0,11477658 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,06657323 0,11469563 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,06657323 0,11461481 ! androgen metabolic process GO:0008209 17 10 0,000 0,06657323 0,11453409 ! phospholipid efflux GO:0033700 19 10 0,000 0,06657323 0,11445349 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,06657323 0,114373 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,06657323 0,11429263 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,06657323 0,11421237 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,06657323 0,11413222 ! pathogenesis GO:0009405 17 10 0,000 0,06657323 0,11405218 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06657323 0,11397226 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,06657323 0,11389244 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,06657323 0,11381274 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,06657323 0,11373315 ! endoderm development GO:0007492 18 10 0,000 0,06657323 0,11365368 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,06657323 0,11357431 ! arginine catabolic process GO:0006527 17 10 0,000 0,06657323 0,11349505 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,06657323 0,11341591 ! proline metabolic process GO:0006560 13 10 0,000 0,06657323 0,11333687 ! phosphagen metabolic process GO:0006599 17 10 0,000 0,06657323 0,11325795 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,06657323 0,11317913 ! V(D)J recombination GO:0033151 34 10 0,000 0,06657323 0,11310042 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,06657323 0,11302183 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,06657323 0,11294334 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,06657323 0,11286496 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,06657323 0,11278669 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,06657323 0,11270853 ! multicellular organism growth GO:0035264 19 10 0,000 0,06657323 0,11263048 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,06657323 0,11255253 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,06657323 0,1124747 ! ruffle organization GO:0031529 17 10 0,000 0,06657323 0,11239697 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,06657323 0,11231934 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,06657323 0,11224183 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,06657323 0,11216442 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,06657323 0,11208712 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,06657323 0,11200992 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,06657323 0,11193284 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,06657323 0,11185585 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,06657323 0,11177898 ! segment specification GO:0007379 15 10 0,000 0,06657323 0,1117022 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,06657323 0,11162554 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,06657323 0,11154898 ! blastoderm segmentation GO:0007350 19 10 0,000 0,06657323 0,11147252 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,06657323 0,11139617 ! response to dsRNA GO:0043331 23 10 0,000 0,06657323 0,11131992 ! DNA ligation GO:0006266 18 10 0,000 0,06657323 0,11124378 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,06657323 0,11116774 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,06657323 0,11109181 ! melanosome localization GO:0032400 16 10 0,000 0,06657323 0,11101598 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,06657323 0,11094025 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,06657323 0,11086463 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,06657323 0,11078911 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,06657323 0,11071369 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,06657323 0,11063837 ! induction of an organ GO:0001759 17 10 0,000 0,06657323 0,11056316 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,06657323 0,11048805 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,06657323 0,11041304 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,06657323 0,11033813 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,06657323 0,11026333 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06657323 0,11018862 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,06657323 0,11011402 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,06657323 0,11003952 ! salivary gland development GO:0007431 28 10 0,000 0,06657323 0,10996512 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,06657323 0,10989082 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,06657323 0,10981662 ! midbrain development GO:0030901 14 10 0,000 0,06657323 0,10974252 ! musculoskeletal movement GO:0050881 16 10 0,000 0,06657323 0,10966852 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,06657323 0,10959462 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,06657323 0,10952081 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,06657323 0,10944711 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,06657323 0,10937351 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,06657323 0,10930001 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,06657323 0,1092266 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,06657323 0,1091533 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,06657323 0,10908009 ! detection of calcium ion GO:0005513 24 10 0,000 0,06657323 0,10900698 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,06657323 0,10893396 ! blastocyst formation GO:0001825 18 10 0,000 0,06657323 0,10886105 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,06657323 0,10878823 ! cerebellar cortex development GO:0021695 16 10 0,000 0,06657323 0,10871551 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,06657323 0,10864289 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,06657323 0,10857037 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,06657323 0,10849794 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,06785444 0,11051226 ! viral reproductive process GO:0022415 132 62 1,000 0,06785444 0,11043864 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,07298276 0,11870631 ! respiratory burst GO:0045730 17 11 0,000 0,07298276 0,11862733 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,07298276 0,11854846 ! neuron fate specification GO:0048665 18 11 0,000 0,07298276 0,11846969 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,07298276 0,11839103 ! thyroid gland development GO:0030878 26 11 0,000 0,07298276 0,11831246 ! synapsis GO:0007129 14 11 0,000 0,07298276 0,11823401 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,07298276 0,11815566 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,07298276 0,11807741 ! response to pain GO:0048265 27 11 0,000 0,07298276 0,11799926 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,07298276 0,11792122 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,07298276 0,11784328 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,07298276 0,11776545 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,07298276 0,11768771 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07298276 0,11761008 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07298276 0,11753255 ! melanocyte differentiation GO:0030318 20 11 0,000 0,07298276 0,11745513 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,07298276 0,1173778 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,07298276 0,11730058 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,07298276 0,11722346 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,07298276 0,11714644 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,07298276 0,11706952 ! UV protection GO:0009650 20 11 0,000 0,07298276 0,11699271 ! adult heart development GO:0007512 16 11 0,000 0,07298276 0,11691599 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,07298276 0,11683937 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07298276 0,11676286 ! macroautophagy GO:0016236 19 11 0,000 0,07298276 0,11668644 ! temperature homeostasis GO:0001659 18 11 0,000 0,07298276 0,11661013 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,07298276 0,11653391 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,07298276 0,11645779 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,07298276 0,11638178 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,07298276 0,11630586 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,07298276 0,11623004 ! regulation of organ growth GO:0046620 14 11 0,000 0,07298276 0,11615432 ! pigment granule localization GO:0051875 20 11 0,000 0,07298276 0,1160787 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,07298276 0,11600318 ! vasoconstriction GO:0042310 20 11 0,000 0,07298276 0,11592775 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,07298276 0,11585243 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,07298276 0,1157772 ! embryonic axis specification GO:0000578 19 11 0,000 0,07298276 0,11570207 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,07298276 0,11562703 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07298276 0,1155521 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,07298276 0,11547726 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,07298276 0,11540251 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,07298276 0,11532787 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,07298276 0,11525332 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,07298276 0,11517887 ! prophase GO:0051324 17 11 0,000 0,07298276 0,11510451 ! neuroblast proliferation GO:0007405 25 11 0,000 0,07298276 0,11503025 ! nucleosome positioning GO:0016584 15 11 0,000 0,07298276 0,11495608 ! regulation of isotype switching GO:0045191 24 11 0,000 0,07298276 0,11488201 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,07298276 0,11480804 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,07298276 0,11473416 ! acid secretion GO:0046717 20 11 0,000 0,07298276 0,11466038 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07298276 0,11458669 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,07298276 0,11451309 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,07298276 0,11443959 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,07298276 0,11436619 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,07298276 0,11429287 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,07298276 0,11421966 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07298276 0,11414653 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,07298276 0,1140735 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,07298276 0,11400057 ! embryonic gut development GO:0048566 19 11 0,000 0,07298276 0,11392772 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,07298276 0,11385497 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,07298276 0,11378231 ! activation of innate immune response GO:0002218 16 11 0,000 0,07298276 0,11370975 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,07298276 0,11363727 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,07298276 0,11356489 ! lysogeny GO:0030069 22 11 0,000 0,07298276 0,11349261 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07298276 0,11342041 ! sequestering of metal ion GO:0051238 15 11 0,000 0,07298276 0,11334831 ! nucleus localization GO:0051647 22 11 0,000 0,07298276 0,11327629 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,07365928 0,11425373 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,07365928 0,11418124 GO:0048609|reproductive process in a multicellular organism, ! gonad development GO:0008406 115 66 1,000 0,07562863 0,11715963 ! chromosome segregation GO:0007059 127 67 1,000 0,07761463 0,12016004 ! secondary metabolic process GO:0019748 125 67 1,000 0,07761463 0,12008394 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,07934845 0,12268878 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,07934845 0,12261118 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,07934845 0,12253368 ! mating GO:0007618 17 12 0,000 0,07934845 0,12245627 ! protein complex disassembly GO:0043241 28 12 0,000 0,07934845 0,12237896 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,07934845 0,12230175 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,07934845 0,12222464 ! hippocampus development GO:0021766 29 12 0,000 0,07934845 0,12214762 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,07934845 0,1220707 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,07934845 0,12199388 ! T cell proliferation GO:0042098 32 12 0,000 0,07934845 0,12191715 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,07934845 0,12184052 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,07934845 0,12176399 ! ventral spinal cord development GO:0021517 25 12 0,000 0,07934845 0,12168755 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,07934845 0,12161121 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,07934845 0,12153497 ! polyamine metabolic process GO:0006595 18 12 0,000 0,07934845 0,12145882 ! mitotic spindle organization GO:0007052 23 12 0,000 0,07934845 0,12138276 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,07934845 0,12130681 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,07934845 0,12123094 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,07934845 0,12115517 ! entry into host cell GO:0030260 34 12 0,000 0,07934845 0,1210795 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07934845 0,12100392 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,07934845 0,12092843 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,07934845 0,12085304 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,07934845 0,12077774 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,07934845 0,12070254 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,07934845 0,12062743 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,07934845 0,12055241 ! snRNA metabolic process GO:0016073 30 12 0,000 0,07934845 0,12047749 GO:0016180|snRNA processing, ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,07934845 0,12040265 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,07934845 0,12032792 ! cranial nerve development GO:0021545 23 12 0,000 0,07934845 0,12025327 ! fucose catabolic process GO:0019317 25 12 0,000 0,07934845 0,12017872 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,07934845 0,12010426 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,07934845 0,12002989 ! autonomic nervous system development GO:0048483 24 12 0,000 0,07934845 0,11995562 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,07934845 0,11988143 ! zymogen activation GO:0031638 18 12 0,000 0,07934845 0,11980734 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,07934845 0,11973334 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,07934845 0,11965943 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,07934845 0,11958561 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,07934845 0,11951188 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,07934845 0,11943825 ! defense response to fungus GO:0050832 15 12 0,000 0,07934845 0,1193647 ! developmental induction GO:0031128 22 12 0,000 0,07934845 0,11929125 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,07934845 0,11921788 ! lamellipodium assembly GO:0030032 24 12 0,000 0,07934845 0,11914461 ! response to cold GO:0009409 17 12 0,000 0,07934845 0,11907142 ! establishment of cell polarity GO:0030010 21 12 0,000 0,07934845 0,11899833 ! localization within membrane GO:0051668 26 12 0,000 0,07934845 0,11892532 ! detection of external stimulus GO:0009581 102 68 1,000 0,07961697 0,11925461 ! viral reproduction GO:0016032 142 68 1,000 0,07961697 0,11918154 ! cell projection assembly GO:0030031 138 68 1,000 0,07961697 0,11910855 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,08163534 0,12205332 ! cellular amino acid catabolic process GO:0009063 120 69 1,000 0,08163534 0,12197867 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,08567061 0,1279299 ! cGMP metabolic process GO:0046068 18 13 0,000 0,08567061 0,12785175 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,08567061 0,12777369 ! regulation of chemokine production GO:0032642 18 13 0,000 0,08567061 0,12769574 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,08567061 0,12761787 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,08567061 0,1275401 ! peroxisomal transport GO:0043574 28 13 0,000 0,08567061 0,12746243 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,08567061 0,12738485 ! organelle fusion GO:0048284 36 13 0,000 0,08567061 0,12730737 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,08567061 0,12722998 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,08567061 0,12715268 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,08567061 0,12707548 ! endocrine pancreas development GO:0031018 25 13 0,000 0,08567061 0,12699837 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,08567061 0,12692135 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,08567061 0,12684443 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,08567061 0,1267676 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,08567061 0,12669087 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,08567061 0,12661422 ! methionine metabolic process GO:0006555 31 13 0,000 0,08567061 0,12653767 ! plasma membrane organization GO:0007009 27 13 0,000 0,08567061 0,12646121 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,08567061 0,12638485 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,08567061 0,12630858 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,08567061 0,12623239 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,08567061 0,12615631 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,08567061 0,12608031 ! exocrine system development GO:0035272 34 13 0,000 0,08567061 0,1260044 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,08567061 0,12592859 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,08567061 0,12585286 ! L-glutamate transport GO:0015813 30 13 0,000 0,08567061 0,12577723 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,08567061 0,12570169 ! protein homotetramerization GO:0051289 24 13 0,000 0,08567061 0,12562624 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,08567061 0,12555088 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,08567061 0,12547561 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,08567061 0,12540043 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,08567061 0,12532534 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,08567061 0,12525034 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,08567061 0,12517542 ! histone methylation GO:0016571 29 13 0,000 0,08567061 0,1251006 ! chromatin silencing GO:0006342 29 13 0,000 0,08567061 0,12502587 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,08567061 0,12495123 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,08567061 0,12487668 ! regulation of epidermis development GO:0045682 19 13 0,000 0,08567061 0,12480221 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,08567061 0,12472784 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,08567061 0,12465355 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,08567061 0,12457935 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,08567061 0,12450524 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,08567061 0,12443122 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,08567061 0,12435728 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,08567061 0,12428344 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,08567061 0,12420968 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,08567061 0,12413601 ! insulin secretion GO:0030073 24 13 0,000 0,08567061 0,12406242 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,08567061 0,12398893 ! acrosome reaction GO:0007340 19 13 0,000 0,08567061 0,12391552 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,08567061 0,1238422 ! rRNA transcription GO:0009303 28 14 0,000 0,09194954 0,13284016 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,09194954 0,13276165 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,09194954 0,13268323 ! water transport GO:0006833 21 14 0,000 0,09194954 0,13260491 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,09194954 0,13252668 ! non-recombinational repair GO:0000726 29 14 0,000 0,09194954 0,13244854 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,09194954 0,13237049 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,09194954 0,13229253 ! RNA polyadenylation GO:0043631 32 14 0,000 0,09194954 0,13221467 ! lipid localization GO:0010876 32 14 0,000 0,09194954 0,13213689 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,09194954 0,13205921 ! regulated secretory pathway GO:0045055 24 14 0,000 0,09194954 0,13198162 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,09194954 0,13190412 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,09194954 0,13182671 ! arginine metabolic process GO:0006525 21 14 0,000 0,09194954 0,13174939 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,09194954 0,13167217 ! regulation of heart rate GO:0002027 25 14 0,000 0,09194954 0,13159503 ! organic alcohol transport GO:0015850 29 14 0,000 0,09194954 0,13151798 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,09194954 0,13144103 ! embryo implantation GO:0007566 30 14 0,000 0,09194954 0,13136416 ! neutral amino acid transport GO:0015804 28 14 0,000 0,09194954 0,13128739 ! bone mineralization GO:0030282 18 14 0,000 0,09194954 0,1312107 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,09194954 0,1311341 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,09194954 0,13105759 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,09194954 0,13098118 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,09194954 0,13090485 ! ribosome assembly GO:0042255 18 14 0,000 0,09194954 0,13082861 ! cerebellum development GO:0021549 23 14 0,000 0,09194954 0,13075245 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,09194954 0,13067639 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,09194954 0,13060042 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,09194954 0,13052453 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,09194954 0,13044873 ! NADP metabolic process GO:0006739 24 14 0,000 0,09194954 0,13037302 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,09194954 0,1302974 ! oxygen transport GO:0015671 22 14 0,000 0,09194954 0,13022186 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,09194954 0,13014642 ! male genitalia development GO:0030539 26 14 0,000 0,09194954 0,13007106 ! regulation of axon extension GO:0030516 43 14 0,000 0,09194954 0,12999578 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,09194954 0,1299206 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,09194954 0,1298455 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,09406477 0,13275576 GO:0090046|regulation of transcription regulator activity, ! rhythmic process GO:0048511 142 75 1,000 0,09406477 0,13267912 ! lactation GO:0007595 30 15 0,000 0,09818551 0,13841155 ! reproductive cellular process GO:0048610 22 15 0,000 0,09818551 0,13833173 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,09818551 0,138252 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,09818551 0,13817236 ! superoxide anion generation GO:0042554 22 15 0,000 0,09818551 0,13809281 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,09818551 0,13801336 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,09818551 0,13793399 ! copper ion transport GO:0006825 22 15 0,000 0,09818551 0,13785472 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,09818551 0,13777554 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,09818551 0,13769645 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,09818551 0,13761745 ! sulfate transport GO:0008272 27 15 0,000 0,09818551 0,13753854 ! response to cAMP GO:0051591 25 15 0,000 0,09818551 0,13745972 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,09818551 0,13738099 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,09818551 0,13730235 ! response to hexose stimulus GO:0009746 25 15 0,000 0,09818551 0,13722381 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,09818551 0,13714535 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,09818551 0,13706698 ! vesicle coating GO:0006901 38 15 0,000 0,09818551 0,1369887 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,09818551 0,13691051 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,09818551 0,13683241 ! regulation of exocytosis GO:0017157 26 15 0,000 0,09818551 0,1367544 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,09818551 0,13667647 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,09818551 0,13659864 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,09818551 0,13652089 ! regulation of vasodilation GO:0042312 27 15 0,000 0,09818551 0,13644324 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,09818551 0,13636567 ! histone deacetylation GO:0016575 24 15 0,000 0,09818551 0,13628819 ! water homeostasis GO:0030104 28 15 0,000 0,09818551 0,1362108 ! cofactor transport GO:0051181 30 15 0,000 0,09818551 0,13613349 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,09818551 0,13605627 ! muscle maintenance GO:0046716 26 15 0,000 0,09818551 0,13597914 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,09818551 0,1359021 ! dopamine metabolic process GO:0042417 35 15 0,000 0,09818551 0,13582515 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,09818551 0,13574828 ! heme biosynthetic process GO:0006783 33 15 0,000 0,09818551 0,1356715 ! cell killing GO:0001906 32 15 0,000 0,09818551 0,13559481 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,09818551 0,1355182 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,09818551 0,13544168 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,09818551 0,13536524 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,09818551 0,1352889 ! actin filament polymerization GO:0030041 27 15 0,000 0,09818551 0,13521263 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,09818551 0,13513646 ! amine catabolic process GO:0009310 136 77 1,000 0,09832234 0,13524859 ! neurotransmitter transport GO:0006836 142 77 1,000 0,09832234 0,13517248 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,09832234 0,13509645 ! lipoprotein metabolic process GO:0042157 147 78 1,000 0,10047128 0,13797152 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,10047128 0,13789401 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,10437884 0,14317659 ! positive regulation of cell size GO:0045793 29 16 0,000 0,10437884 0,14309625 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,10437884 0,14301599 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,10437884 0,14293582 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,10437884 0,14285575 ! bone remodeling GO:0046849 28 16 0,000 0,10437884 0,14277576 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,10437884 0,14269587 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10437884 0,14261606 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,10437884 0,14253634 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,10437884 0,14245671 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,10437884 0,14237717 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,10437884 0,14229772 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,10437884 0,14221836 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,10437884 0,14213908 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,10437884 0,14205989 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,10437884 0,1419808 ! protein polyubiquitination GO:0000209 41 16 0,000 0,10437884 0,14190179 ! glutamate metabolic process GO:0006536 25 16 0,000 0,10437884 0,14182286 ! response to osmotic stress GO:0006970 27 16 0,000 0,10437884 0,14174403 ! fructose metabolic process GO:0006000 25 16 0,000 0,10437884 0,14166528 ! L-amino acid transport GO:0015807 33 16 0,000 0,10437884 0,14158662 ! stem cell development GO:0048864 46 16 0,000 0,10437884 0,14150805 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,10437884 0,14142957 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,10437884 0,14135117 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,10437884 0,14127286 ! negative regulation of immune response GO:0050777 38 16 0,000 0,10437884 0,14119464 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,10437884 0,1411165 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,10437884 0,14103845 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,10437884 0,14096048 ! neuron recognition GO:0008038 40 16 0,000 0,10437884 0,1408826 ! mRNA splice site selection GO:0006376 44 16 0,000 0,10437884 0,14080481 ! tissue regeneration GO:0042246 27 16 0,000 0,10437884 0,1407271 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,10437884 0,14064948 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,10437884 0,14057195 ! biomineral formation GO:0031214 22 16 0,000 0,10437884 0,1404945 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,10437884 0,14041713 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,10437884 0,14033985 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,10437884 0,14026266 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,10437884 0,14018555 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,10437884 0,14010852 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,10437884 0,14003158 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,10437884 0,13995473 ! peptide hormone processing GO:0016486 27 16 0,000 0,10437884 0,13987795 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,10480804 0,14037612 ! muscle cell differentiation GO:0042692 178 81 1,000 0,1069953 0,14322714 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,11052981 0,1478775 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,11052981 0,14779656 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,11052981 0,14771571 ! signal complex assembly GO:0007172 47 17 0,000 0,11052981 0,14763495 ! filopodium assembly GO:0046847 42 17 0,000 0,11052981 0,14755428 ! endothelial cell migration GO:0043542 31 17 0,000 0,11052981 0,14747369 ! gene silencing by RNA GO:0031047 38 17 0,000 0,11052981 0,14739319 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,11052981 0,14731278 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,11052981 0,14723246 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,11052981 0,14715222 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,11052981 0,14707207 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,11052981 0,14699201 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,11052981 0,14691204 ! myoblast differentiation GO:0045445 50 17 0,000 0,11052981 0,14683215 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,11052981 0,14675235 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,11052981 0,14667264 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,11052981 0,14659301 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,11052981 0,14651347 ! NAD metabolic process GO:0019674 33 17 0,000 0,11052981 0,14643402 ! membrane budding GO:0006900 42 17 0,000 0,11052981 0,14635465 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,11052981 0,14627537 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,11052981 0,14619617 ! genitalia development GO:0048806 32 17 0,000 0,11052981 0,14611706 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,11052981 0,14603803 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,11052981 0,14595909 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,11052981 0,14588024 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,11052981 0,14580147 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,11052981 0,14572279 ! steroid catabolic process GO:0006706 34 17 0,000 0,11052981 0,14564419 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,11052981 0,14556567 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,11052981 0,14548724 ! gas transport GO:0015669 26 17 0,000 0,11052981 0,1454089 ! organic cation transport GO:0015695 32 17 0,000 0,11052981 0,14533064 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,11052981 0,14525246 ! exocytosis GO:0006887 153 83 1,000 0,11140625 0,14632553 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,11140625 0,1462469 ! response to nutrient GO:0007584 135 84 1,000 0,1136294 0,14908519 ! digestion GO:0007586 130 84 1,000 0,1136294 0,14900517 ! negative regulation of transport GO:0051051 164 85 1,000 0,11586398 0,15185392 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,1166387 0,15278732 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,1166387 0,15270544 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,1166387 0,15262365 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,1166387 0,15254195 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,1166387 0,15246033 ! adult walking behavior GO:0007628 36 18 0,000 0,1166387 0,1523788 ! patterning of blood vessels GO:0001569 43 18 0,000 0,1166387 0,15229736 ! heart looping GO:0001947 34 18 0,000 0,1166387 0,152216 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,1166387 0,15213473 ! centrosome cycle GO:0007098 26 18 0,000 0,1166387 0,15205355 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,1166387 0,15197246 ! glycine metabolic process GO:0006544 30 18 0,000 0,1166387 0,15189145 ! glutamine metabolic process GO:0006541 29 18 0,000 0,1166387 0,15181052 ! response to retinoic acid GO:0032526 31 18 0,000 0,1166387 0,15172969 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,1166387 0,15164894 ! DNA integration GO:0015074 32 18 0,000 0,1166387 0,15156827 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,1166387 0,1514877 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,1166387 0,1514072 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,1166387 0,1513268 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,1166387 0,15124647 ! neural crest cell migration GO:0001755 41 18 0,000 0,1166387 0,15116624 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,1166387 0,15108608 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,1166387 0,15100602 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,1166387 0,15092604 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,1166387 0,15084614 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,1166387 0,15076633 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,1166387 0,1506866 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,1166387 0,15060695 ! detection of bacterium GO:0016045 22 18 0,000 0,1166387 0,15052739 ! nerve development GO:0021675 34 18 0,000 0,1166387 0,15044792 ! microspike assembly GO:0030035 46 18 0,000 0,1166387 0,15036853 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,11810973 0,15218463 GO:0002696|positive regulation of leukocyte activation, ! nucleosome assembly GO:0006334 126 87 1,000 0,12036639 0,15501059 ! chromatin assembly GO:0031497 128 88 1,000 0,12263371 0,15784729 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,12263371 0,15776416 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,12270581 0,15777384 ! positive regulation of translation GO:0045727 31 19 0,000 0,12270581 0,15769085 ! negative regulation of defense response GO:0031348 27 19 0,000 0,12270581 0,15760794 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,12270581 0,15752512 ! neuron maturation GO:0042551 46 19 0,000 0,12270581 0,15744239 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,12270581 0,15735974 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,12270581 0,15727718 ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,12270581 0,15719471 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,12270581 0,15711232 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,12270581 0,15703002 ! memory GO:0007613 34 19 0,000 0,12270581 0,1569478 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,12270581 0,15686568 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,12270581 0,15678363 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,12270581 0,15670168 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,12270581 0,1566198 ! pigmentation during development GO:0048066 42 19 0,000 0,12270581 0,15653802 ! response to vitamin A GO:0033189 32 19 0,000 0,12270581 0,15645632 ! heme metabolic process GO:0042168 40 19 0,000 0,12270581 0,1563747 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,12270581 0,15629317 ! response to fungus GO:0009620 26 19 0,000 0,12270581 0,15621173 ! peptide cross-linking GO:0018149 39 19 0,000 0,12270581 0,15613037 ! protein export from nucleus GO:0006611 40 19 0,000 0,12270581 0,15604909 ! heart process GO:0003015 32 19 0,000 0,12270581 0,1559679 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,12270581 0,15588679 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,12270581 0,15580577 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,12270581 0,15572483 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,12270581 0,15564398 ! vitamin transport GO:0051180 31 19 0,000 0,12270581 0,15556321 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,12270581 0,15548252 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,12270581 0,15540192 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,12270581 0,1553214 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,12270581 0,15524097 ! cilium assembly GO:0042384 38 19 0,000 0,12270581 0,15516061 ! peptide hormone secretion GO:0030072 32 19 0,000 0,12270581 0,15508034 ! response to unfolded protein GO:0006986 139 90 1,000 0,12719932 0,16067629 ! protein secretion GO:0009306 45 20 0,000 0,12873142 0,16252758 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,12873142 0,16244363 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,12873142 0,16235977 ! positive regulation of ossification GO:0045778 50 20 0,000 0,12873142 0,16227599 ! skin development GO:0043588 42 20 0,000 0,12873142 0,1621923 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,12873142 0,1621087 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,12873142 0,16202518 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,12873142 0,16194175 ! response to vitamin GO:0033273 36 20 0,000 0,12873142 0,1618584 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,12873142 0,16177514 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,12873142 0,16169196 ! bile acid metabolic process GO:0008206 34 20 0,000 0,12873142 0,16160887 ! retinoid metabolic process GO:0001523 34 20 0,000 0,12873142 0,16152587 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,12873142 0,16144295 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,12873142 0,16136012 ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,12873142 0,16127737 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,12873142 0,16119471 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,12873142 0,16111213 ! peptide secretion GO:0002790 38 20 0,000 0,12873142 0,16102963 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,12873142 0,16094722 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,12873142 0,16086489 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,12873142 0,16078265 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,12873142 0,1607005 GO:0006626|protein targeting to mitochondrion, ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,12873142 0,16061842 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,12873142 0,16053643 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,12873142 0,16045453 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,12873142 0,1603727 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,12873142 0,16029096 ! regulation of glucose import GO:0046324 30 20 0,000 0,12873142 0,16020931 GO:0010827|regulation of glucose transport, ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,12873142 0,16012773 ! negative regulation of translation GO:0017148 32 20 0,000 0,12873142 0,16004624 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,12873142 0,15996484 ! ossification GO:0001503 205 91 1,000 0,12949713 0,16083451 ! bone development GO:0060348 206 92 1,000 0,1318046 0,16361719 ! protein-DNA complex assembly GO:0065004 134 92 1,000 0,1318046 0,1635341 ! regulation of cell killing GO:0031341 46 21 0,000 0,13471582 0,16706129 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,13471582 0,16697653 ! hormone secretion GO:0046879 39 21 0,000 0,13471582 0,16689186 ! cAMP metabolic process GO:0046058 41 21 0,000 0,13471582 0,16680727 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,13471582 0,16672277 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,13471582 0,16663835 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,13471582 0,16655402 ! smooth muscle contraction GO:0006939 48 21 0,000 0,13471582 0,16646977 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,13471582 0,16638561 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,13471582 0,16630154 ! plasma membrane fusion GO:0045026 33 21 0,000 0,13471582 0,16621754 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,13471582 0,16613364 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,13471582 0,16604982 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,13471582 0,16596608 ! sensory perception of pain GO:0019233 33 21 0,000 0,13471582 0,16588243 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,13471582 0,16579886 ! collagen fibril organization GO:0030199 62 21 0,000 0,13471582 0,16571538 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,13471582 0,16563198 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,13471582 0,16554866 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,13471582 0,16546543 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,13471582 0,16538228 ! collagen catabolic process GO:0030574 29 21 0,000 0,13471582 0,16529922 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,13471582 0,16521623 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,13471582 0,16513334 ! sperm-egg recognition GO:0035036 23 21 0,000 0,13471582 0,16505052 ! actin filament-based movement GO:0030048 47 21 0,000 0,13471582 0,16496779 ! nitrogen compound catabolic process GO:0044270 167 94 1,000 0,13644761 0,16700477 ! female pregnancy GO:0007565 166 94 1,000 0,13644761 0,16692114 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,13644761 0,16683759 ! nucleosome organization GO:0034728 143 95 1,000 0,13878268 0,16960784 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,14065927 0,1718153 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,14065927 0,17172943 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,14065927 0,17164366 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,14065927 0,17155796 GO:0034105|positive regulation of tissue remodeling, ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,14065927 0,17147235 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,14065927 0,17138683 ! central nervous system neuron development GO:0021954 47 22 0,000 0,14065927 0,1713014 ! fucose metabolic process GO:0006004 44 22 0,000 0,14065927 0,17121604 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,14065927 0,17113078 ! stem cell differentiation GO:0048863 57 22 0,000 0,14065927 0,17104559 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,14065927 0,1709605 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,14065927 0,17087548 ! vasodilation GO:0042311 40 22 0,000 0,14065927 0,17079056 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,14065927 0,17070571 ! G1 phase GO:0051318 44 22 0,000 0,14065927 0,17062095 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,14065927 0,17053628 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,14065927 0,17045169 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,14065927 0,17036718 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,14065927 0,17028275 ! sarcomere organization GO:0045214 32 22 0,000 0,14065927 0,17019841 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,14065927 0,17011416 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,14065927 0,17002998 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,14065927 0,16994589 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,14065927 0,16986189 ! protein stabilization GO:0050821 41 22 0,000 0,14065927 0,16977796 ! sex differentiation GO:0007548 171 96 1,000 0,14112647 0,17025776 ! regulation of T cell activation GO:0050863 175 96 1,000 0,14112647 0,17017373 ! transcription initiation GO:0006352 171 97 1,000 0,14347877 0,17292483 ! forebrain development GO:0030900 210 98 1,000 0,14583934 0,17568319 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,14656207 0,1764668 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,14656207 0,17637987 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,14656207 0,17629302 ! gluconeogenesis GO:0006094 38 23 0,000 0,14656207 0,17620626 ! glycerol metabolic process GO:0006071 40 23 0,000 0,14656207 0,17611959 ! viral genome replication GO:0019079 44 23 0,000 0,14656207 0,176033 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,14656207 0,1759465 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,14656207 0,17586008 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,14656207 0,17577375 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,14656207 0,1756875 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,14656207 0,17560134 ! peroxisome organization GO:0007031 43 23 0,000 0,14656207 0,17551526 ! lysosome organization GO:0007040 47 23 0,000 0,14656207 0,17542927 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,14656207 0,17534335 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,14656207 0,17525753 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,14656207 0,17517179 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,14656207 0,17508613 ! fatty acid transport GO:0015908 47 23 0,000 0,14656207 0,17500055 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,14656207 0,17491506 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,14656207 0,17482965 ! hormone transport GO:0009914 41 23 0,000 0,14656207 0,17474433 ! cell-cell recognition GO:0009988 28 23 0,000 0,14656207 0,17465909 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,14656207 0,17457393 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,14656207 0,17448885 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,14656207 0,17440386 ! hormone metabolic process GO:0042445 171 100 1,000 0,15058443 0,1791031 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,15242448 0,18120341 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,15242448 0,18111528 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,15242448 0,18102723 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,15242448 0,18093927 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,15242448 0,18085139 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,15242448 0,1807636 ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,15242448 0,18067589 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,15242448 0,18058827 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,15242448 0,18050073 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,15242448 0,18041328 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,15242448 0,18032591 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,15242448 0,18023863 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,15242448 0,18015143 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,15242448 0,18006432 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,15242448 0,17997729 ! platelet activation GO:0030168 41 24 0,000 0,15242448 0,17989034 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,15242448 0,17980348 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,15242448 0,1797167 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,15242448 0,17963001 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,15242448 0,1795434 ! regulation of amine transport GO:0051952 41 24 0,000 0,15242448 0,17945687 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,15824679 0,18622202 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,15824679 0,18613236 ! leukocyte adhesion GO:0007159 55 25 0,000 0,15824679 0,18604279 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,15824679 0,1859533 ! phototransduction GO:0007602 37 25 0,000 0,15824679 0,1858639 ! keratinization GO:0031424 37 25 0,000 0,15824679 0,18577459 ! vacuole organization GO:0007033 49 25 0,000 0,15824679 0,18568536 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,15824679 0,18559621 ! receptor metabolic process GO:0043112 53 25 0,000 0,15824679 0,18550716 ! chromosome condensation GO:0030261 48 25 0,000 0,15824679 0,18541818 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,15824679 0,1853293 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,15824679 0,18524049 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,15824679 0,18515178 ! immunoglobulin production GO:0002377 62 25 0,000 0,15824679 0,18506315 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,15824679 0,1849746 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,15824679 0,18488614 ! liver development GO:0001889 55 25 0,000 0,15824679 0,18479776 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,16402927 0,19145891 ! initiation of viral infection GO:0019059 60 26 0,000 0,16402927 0,19136748 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,16402927 0,19127613 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,16402927 0,19118488 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,16402927 0,19109371 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,16402927 0,19100262 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,16402927 0,19091163 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,16402927 0,19082072 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,16402927 0,19072989 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,16402927 0,19063915 ! osteoblast differentiation GO:0001649 63 26 0,000 0,16402927 0,1905485 ! neural crest cell development GO:0014032 59 26 0,000 0,16402927 0,19045794 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,16402927 0,19036746 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,16402927 0,19027707 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,16402927 0,19018676 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! response to estradiol stimulus GO:0032355 43 26 0,000 0,16402927 0,19009654 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,16402927 0,1900064 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,16402927 0,18991635 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,16402927 0,18982639 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,16402927 0,18973651 ! blastocyst development GO:0001824 50 26 0,000 0,16402927 0,18964671 ! telomere organization GO:0032200 46 26 0,000 0,16402927 0,189557 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,16402927 0,18946738 ! neural tube closure GO:0001843 58 26 0,000 0,16402927 0,18937784 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,16402927 0,18928838 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,16402927 0,18919901 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,16977218 0,19573074 ! embryonic pattern specification GO:0009880 49 27 0,000 0,16977218 0,19563842 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,16977218 0,19554618 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,16977218 0,19545403 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,16977218 0,19536196 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,16977218 0,19526998 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,16977218 0,19517809 ! iron ion transport GO:0006826 65 27 0,000 0,16977218 0,19508629 ! superoxide metabolic process GO:0006801 41 27 0,000 0,16977218 0,19499457 ! tube lumen formation GO:0035148 59 27 0,000 0,16977218 0,19490293 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,16977218 0,19481139 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,16977218 0,19471993 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,16977218 0,19462855 ! neuron fate commitment GO:0048663 52 28 0,000 0,17547581 0,20107289 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,17547581 0,20097862 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,17547581 0,20088444 ! vesicle docking GO:0048278 55 28 0,000 0,17547581 0,20079035 ! circadian rhythm GO:0007623 56 28 0,000 0,17547581 0,20069635 ! fat cell differentiation GO:0045444 57 28 0,000 0,17547581 0,20060243 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,17547581 0,2005086 ! sperm motility GO:0030317 37 28 0,000 0,17547581 0,20041486 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,17547581 0,20032121 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,17547581 0,20022765 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,17547581 0,20013417 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,17547581 0,20004078 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,17547581 0,19994748 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,17547581 0,19985426 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,17547581 0,19976114 ! glutathione metabolic process GO:0006749 42 28 0,000 0,17547581 0,19966809 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,17547581 0,19957514 ! lipid oxidation GO:0034440 48 28 0,000 0,17547581 0,19948227 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,17547581 0,19938949 ! translational initiation GO:0006413 66 29 0,000 0,18114041 0,20573036 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,18114041 0,20563476 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,18114041 0,20553925 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,18114041 0,20544383 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,18114041 0,2053485 ! primary neural tube formation GO:0014020 61 29 0,000 0,18114041 0,20525325 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,18114041 0,2051581 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,18114041 0,20506303 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,18114041 0,20496805 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,18114041 0,20487315 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,18114041 0,20477835 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,18676625 0,21104068 ! phenol metabolic process GO:0018958 56 30 0,000 0,18676625 0,21094311 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,18676625 0,21084563 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,18676625 0,21074824 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,18676625 0,21065094 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,18676625 0,21055373 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,18676625 0,21045661 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,18676625 0,21035959 ! acute-phase response GO:0006953 50 30 0,000 0,18676625 0,21026265 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,18676625 0,2101658 ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,18676625 0,21006903 ! determination of left/right symmetry GO:0007368 53 30 0,000 0,18676625 0,20997236 ! cell fate determination GO:0001709 64 30 0,000 0,18676625 0,20987578 ! phospholipid transport GO:0015914 65 30 0,000 0,18676625 0,20977928 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,18676625 0,20968288 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,18676625 0,20958656 GO:0046496|nicotinamide nucleotide metabolic process, ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,18676625 0,20949033 GO:0043433|negative regulation of transcription factor activity, ! regulation of coagulation GO:0050818 52 30 0,000 0,18676625 0,20939419 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,19235359 0,21555955 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,19235359 0,21546072 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,19235359 0,21536197 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,19235359 0,21526332 ! regulation of innate immune response GO:0045088 57 31 0,000 0,19235359 0,21516476 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,19235359 0,21506628 ! detection of light stimulus GO:0009583 44 31 0,000 0,19235359 0,2149679 ! natural killer cell activation GO:0030101 50 31 0,000 0,19235359 0,21486961 ! cofactor catabolic process GO:0051187 54 31 0,000 0,19235359 0,2147714 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,19235359 0,21467329 ! eye morphogenesis GO:0048592 65 31 0,000 0,19235359 0,21457526 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,19235359 0,21447733 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,19790271 0,22056401 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,19790271 0,22046344 ! collagen metabolic process GO:0032963 49 32 0,000 0,19790271 0,22036295 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,19790271 0,22026256 ! mesoderm formation GO:0001707 73 32 0,000 0,19790271 0,22016226 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,19790271 0,22006205 ! BMP signaling pathway GO:0030509 71 32 0,000 0,19790271 0,21996193 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,19790271 0,2198619 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,19790271 0,21976196 ! gene silencing GO:0016458 71 32 0,000 0,19790271 0,21966212 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,20341385 0,22567668 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,20341385 0,22557424 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,20341385 0,22547189 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,20341385 0,22536963 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,20341385 0,22526747 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,20341385 0,2251654 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,20341385 0,22506342 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,20888728 0,23101477 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,20888728 0,23091024 ! spliceosome assembly GO:0000245 75 34 0,000 0,20888728 0,2308058 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,20888728 0,23070146 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,20888728 0,23059721 ! formation of primary germ layer GO:0001704 76 34 0,000 0,20888728 0,23049306 ! cell fate specification GO:0001708 56 34 0,000 0,20888728 0,230389 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,20888728 0,23028503 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,20888728 0,23018116 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,21432326 0,2360648 ! negative regulation of secretion GO:0051048 68 35 0,000 0,21432326 0,23595842 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,21432326 0,23585213 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,21432326 0,23574594 ! membrane docking GO:0022406 69 35 0,000 0,21432326 0,23563984 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,21432326 0,23553384 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,21432326 0,23542793 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,21432326 0,23532212 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,21432326 0,23521641 ! ceramide metabolic process GO:0006672 72 35 0,000 0,21432326 0,23511079 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,21432326 0,23500526 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,21432326 0,23489983 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,21972204 0,24070894 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,21972204 0,24060105 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,21972204 0,24049325 ! protein targeting to membrane GO:0006612 75 36 0,000 0,21972204 0,24038555 ! aerobic respiration GO:0009060 56 36 0,000 0,21972204 0,24027795 ! cytokine production GO:0001816 68 36 0,000 0,21972204 0,24017044 ! embryonic organ development GO:0048568 67 36 0,000 0,21972204 0,24006303 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,21972204 0,23995571 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,22508386 0,24570147 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,22508386 0,24559173 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,22508386 0,24548209 ! odontogenesis GO:0042476 74 37 0,000 0,22508386 0,24537255 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,22508386 0,2452631 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,22508386 0,24515376 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,230409 0,25084188 ! organic anion transport GO:0015711 82 38 0,000 0,230409 0,25073015 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,230409 0,25061851 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,230409 0,25050698 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,230409 0,25039554 ! spermatid development GO:0007286 69 38 0,000 0,230409 0,25028421 ! neural tube formation GO:0001841 79 38 0,000 0,230409 0,25017297 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,23569769 0,25580162 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,23569769 0,25568803 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,23569769 0,25557455 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,23569769 0,25546116 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,23569769 0,25534787 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,24095018 0,26092256 ! mismatch repair GO:0006298 58 40 0,000 0,24095018 0,26080695 ! RNA export from nucleus GO:0006405 61 41 0,000 0,24616672 0,26633539 ! mRNA catabolic process GO:0006402 79 41 0,000 0,24616672 0,26621749 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,24616672 0,26609969 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,24616672 0,265982 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,24616672 0,26586442 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,24616672 0,26574693 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,24616672 0,26562955 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,24616672 0,26551228 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,24616672 0,2653951 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,24616672 0,26527804 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,24616672 0,26516107 ! RNA modification GO:0009451 64 41 0,000 0,24616672 0,26504421 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,25134756 0,27050313 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,25134756 0,27038401 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,25134756 0,27026501 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,25134756 0,2701461 ! regulation of protein secretion GO:0050708 77 42 0,000 0,25134756 0,27002731 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,25134756 0,26990861 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,25649294 0,27531294 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,25649294 0,27519203 ! regulation of tube size GO:0035150 76 43 0,000 0,25649294 0,27507123 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,25649294 0,27495053 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,25649294 0,27482994 ! ion transmembrane transport GO:0034220 79 43 0,000 0,25649294 0,27470945 ! neuron migration GO:0001764 85 43 0,000 0,25649294 0,27458907 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,25649294 0,27446879 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,2616031 0,27981452 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,2616031 0,27969207 ! striated muscle contraction GO:0006941 85 44 0,000 0,2616031 0,27956972 ! phagocytosis GO:0006909 105 44 0,000 0,2616031 0,27944747 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,2616031 0,27932534 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,26667828 0,28461994 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,26667828 0,28449565 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,26667828 0,28437147 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,26667828 0,2842474 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,26667828 0,28412343 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,27171872 0,2893674 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,27171872 0,28924132 ! glycolysis GO:0006096 71 46 0,000 0,27171872 0,28911534 ! leukocyte migration GO:0050900 75 46 0,000 0,27171872 0,28898947 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,27171872 0,28886372 ! cell growth GO:0016049 90 46 0,000 0,27171872 0,28873807 ! neural tube development GO:0021915 91 47 0,000 0,27672465 0,2939297 ! positive regulation of defense response GO:0031349 88 48 0,000 0,28169631 0,29908044 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,28169631 0,29895052 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,28169631 0,29882071 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,28169631 0,29869101 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,28169631 0,29856143 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,28169631 0,29843196 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,28169631 0,2983026 ! response to calcium ion GO:0051592 94 49 0,000 0,28663394 0,30339979 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,28663394 0,30326839 ! protein homooligomerization GO:0051260 84 49 0,000 0,28663394 0,30313711 ! regulation of ion transport GO:0043269 86 50 0,000 0,29153777 0,30818986 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,29153777 0,30805656 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,29153777 0,30792338 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,29153777 0,30779031 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,29153777 0,30765735 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,29153777 0,30752451 ! viral infectious cycle GO:0019058 104 51 0,000 0,29640802 0,31252689 ! peptide metabolic process GO:0006518 80 51 0,000 0,29640802 0,31239206 ! Notch signaling pathway GO:0007219 111 52 0,000 0,30124493 0,3173529 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,30124493 0,31721611 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,30124493 0,31707944 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,30124493 0,31694288 ! excretion GO:0007588 87 52 0,000 0,30124493 0,31680645 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,30124493 0,31667013 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,30124493 0,31653392 ! amino acid activation GO:0043038 98 52 0,000 0,30124493 0,31639784 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,30604873 0,32130513 ! inner ear development GO:0048839 89 53 0,000 0,30604873 0,32116711 ! chromatin remodeling GO:0006338 122 53 0,000 0,30604873 0,32102921 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,30604873 0,32089143 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,30604873 0,32075377 ! regulation of translational initiation GO:0006446 87 54 0,000 0,31081963 0,32561422 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,31081963 0,32547465 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,31081963 0,3253352 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 0,000 0,31081963 0,32519587 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,31081963 0,32505666 ! membrane fusion GO:0006944 122 54 0,000 0,31081963 0,32491757 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,31081963 0,32477859 ! RNA catabolic process GO:0006401 103 55 0,000 0,31555787 0,32958866 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,31555787 0,32944781 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,31555787 0,32930708 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,31555787 0,32916647 ! cell recognition GO:0008037 98 55 0,000 0,31555787 0,32902598 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,31555787 0,32888561 ! glucose catabolic process GO:0006007 88 56 0,000 0,32026366 0,33364781 ! RNA elongation GO:0006354 90 56 0,000 0,32026366 0,33350559 ! chloride transport GO:0006821 102 57 0,000 0,32493723 0,33822823 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,32493723 0,33808418 ! regulation of actin filament length GO:0030832 118 58 0,000 0,3295788 0,34276756 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,3295788 0,3426217 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,3295788 0,34247597 ! gastrulation GO:0007369 122 58 0,000 0,3295788 0,34233036 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,3295788 0,34218487 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,3295788 0,34203951 ! regulation of endocytosis GO:0030100 104 60 0,000 0,3387668 0,3514256 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,3387668 0,35127644 ! positive regulation of secretion GO:0051047 110 61 0,000 0,34331366 0,35584017 ! regulation of cellular component size GO:0032535 125 61 0,000 0,34331366 0,35568926 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,34331366 0,35553848 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,34331366 0,35538783 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,34331366 0,3552373 ! regulation of heart contraction GO:0008016 123 61 0,000 0,34331366 0,35508691 ! camera-type eye development GO:0043010 126 61 0,000 0,34331366 0,35493664 ! proton transport GO:0015992 117 61 0,000 0,34331366 0,35478649 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,34331366 0,35463648 ! tRNA processing GO:0008033 102 62 0,000 0,34782938 0,35914928 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,35231418 0,36362634 ! mesoderm development GO:0007498 128 63 0,000 0,35231418 0,36347278 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,35231418 0,36331935 ! hydrogen transport GO:0006818 121 64 0,000 0,35676827 0,36775733 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,35676827 0,36760223 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,36119184 0,37200324 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,36119184 0,37184647 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,36558512 0,37621081 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,36558512 0,3760524 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,36558512 0,37589413 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,36994831 0,38022033 GO:0035113|embryonic appendage morphogenesis, ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,36994831 0,38006044 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,36994831 0,37990069 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,37428162 0,38418907 ! hexose catabolic process GO:0019320 113 68 0,000 0,37428162 0,38402772 ! extracellular matrix organization GO:0030198 146 68 0,000 0,37428162 0,3838665 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,37428162 0,38370541 ! regulation of lipase activity GO:0060191 137 68 0,000 0,37428162 0,38354446 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,37858524 0,38779192 ! single fertilization GO:0007338 83 69 0,000 0,37858524 0,3876294 ! cell redox homeostasis GO:0045454 114 70 0,000 0,38285938 0,39184142 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,38710425 0,39601996 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,38710425 0,3958542 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,38710425 0,39568857 ! appendage morphogenesis GO:0035107 150 72 0,000 0,39132003 0,39983055 GO:0035108|limb morphogenesis, ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,39132003 0,39966339 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,39132003 0,39949638 ! appendage development GO:0048736 151 73 0,000 0,39550694 0,40360211 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,39550694 0,40343359 ! regulation of immune effector process GO:0002697 156 73 0,000 0,39550694 0,40326521 ! amino acid transport GO:0006865 148 74 0,000 0,39966516 0,407335 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,39966516 0,40716513 ! transition metal ion transport GO:0000041 143 75 0,000 0,40379489 0,41120089 ! eye development GO:0001654 155 75 0,000 0,40379489 0,41102955 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,40789634 0,41503155 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,40789634 0,41485876 ! regulation of blood pressure GO:0008217 134 76 0,000 0,40789634 0,41468612 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,41196968 0,41865305 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,41196968 0,41847897 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,41196968 0,41830504 ! antigen processing and presentation GO:0019882 117 78 0,000 0,41601511 0,42223719 ! fertilization GO:0009566 99 78 0,000 0,41601511 0,42206184 ! blood coagulation GO:0007596 151 79 0,000 0,42003283 0,42596106 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,42003283 0,42578432 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,42003283 0,42560771 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,42402302 0,42947273 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,42402302 0,42929475 ! positive regulation of phosphorylation GO:0042327 149 81 0,000 0,42798586 0,43312737 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,42798586 0,43294802 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,43583028 0,4407009 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 0,000 0,43583028 0,44051856 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,43583028 0,44033638 ! inorganic anion transport GO:0015698 156 83 0,000 0,43583028 0,44015435 ! hemostasis GO:0007599 165 85 0,000 0,44356755 0,44778328 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,44356755 0,44759832 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,44739647 0,45127563 ! regulation of lyase activity GO:0051339 169 86 0,000 0,44739647 0,45108938 ! alcohol catabolic process GO:0046164 142 87 0,000 0,45119914 0,45473577 ! cellular respiration GO:0045333 143 88 0,000 0,45497576 0,4583529 ! amine biosynthetic process GO:0009309 146 88 0,000 0,45497576 0,45816396 ! sensory perception of smell GO:0007608 117 88 0,000 0,45497576 0,45797518 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,45872649 0,46156046 ! cellular defense response GO:0006968 123 89 0,000 0,45872649 0,46137044 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,46245151 0,46492553 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,46245151 0,46473428 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,466151 0,46825942 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,466151 0,46806696 ! amine transport GO:0015837 181 93 0,000 0,47347409 0,47522482 ! vitamin metabolic process GO:0006766 153 93 0,000 0,47347409 0,47502966 ! regulation of defense response GO:0031347 171 95 0,000 0,48069713 0,48207845 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,48069713 0,48188063 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,48069713 0,48168298 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,48069713 0,48148549 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,48069713 0,48128816 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,48782149 0,48822118 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,49134708 0,49154828 ! mRNA transport GO:0051028 185 100 0,000 0,49832591 0,49832591