pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6565-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of protein export from nucleus GO:0046825 6 6 4,000 3,161E-10 7,27E-07 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 8,000 6,284E-10 7,227E-07 ! regulation of intracellular protein transport GO:0033157 59 35 7,000 6,44E-10 4,937E-07 ! organ growth GO:0035265 11 7 4,000 1,098E-09 6,316E-07 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 7,000 3,064E-09 1,409E-06 ! regulation of protein localization GO:0032880 132 85 9,000 4,224E-09 1,619E-06 ! cell cycle checkpoint GO:0000075 108 64 8,000 5,154E-09 1,694E-06 ! regulation of intracellular transport GO:0032386 78 49 7,000 1,11E-08 3,192E-06 ! negative regulation of peptide secretion GO:0002792 6 5 3,000 3,03E-08 7,742E-06 GO:0046676|negative regulation of insulin secretion, ! glycolysis GO:0006096 53 44 6,000 1,143E-07 2,63E-05 ! regulation of growth hormone secretion GO:0060123 11 7 3,000 2,091E-07 4,373E-05 ! negative regulation of transport GO:0051051 116 73 7,000 2,762E-07 5,293E-05 ! DNA damage checkpoint GO:0000077 53 31 5,000 2,807E-07 4,967E-05 ! regulation of multicellular organism growth GO:0040014 65 50 6,000 2,85E-07 4,682E-05 ! positive regulation of hormone secretion GO:0046887 24 17 4,000 3,011E-07 4,617E-05 ! regulation of protein stability GO:0031647 48 32 5,000 3,43E-07 4,93E-05 ! regulation of protein transport GO:0051223 114 76 7,000 3,787E-07 5,124E-05 GO:0070201|regulation of establishment of protein localization, ! apoptotic mitochondrial changes GO:0008637 29 18 4,000 4,139E-07 5,289E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 3,000 4,154E-07 5,028E-05 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 4,154E-07 4,777E-05 ! gland development GO:0048732 148 77 7,000 4,195E-07 4,594E-05 ! glucose catabolic process GO:0006007 66 54 6,000 4,904E-07 5,127E-05 ! DNA integrity checkpoint GO:0031570 57 34 5,000 5,016E-07 5,016E-05 ! DNA damage response, signal transduction GO:0042770 96 56 6,000 6,327E-07 6,064E-05 ! positive regulation of MAP kinase activity GO:0043406 121 85 7,000 9,033E-07 8,31E-05 ! activation of pro-apoptotic gene products GO:0008633 36 21 4,000 9,62E-07 8,51E-05 ! regulation of insulin secretion GO:0050796 26 21 4,000 9,62E-07 8,195E-05 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 3,000 1,229E-06 1,009E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of cell-matrix adhesion GO:0001952 51 22 4,000 1,236E-06 9,803E-05 GO:0010810|regulation of cell-substrate adhesion, ! hexose catabolic process GO:0019320 82 64 6,000 1,597E-06 1,224E-04 ! focal adhesion formation GO:0048041 24 11 3,000 1,918E-06 1,423E-04 ! regulation of peptide secretion GO:0002791 34 25 4,000 2,44E-06 1,754E-04 ! homophilic cell adhesion GO:0007156 149 100 7,000 3,12E-06 2,175E-04 ! monosaccharide catabolic process GO:0046365 91 71 6,000 3,244E-06 2,195E-04 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 6,000 3,567E-06 2,344E-04 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of protein import into nucleus GO:0042307 23 13 3,000 4,097E-06 2,618E-04 ! cellular response to hormone stimulus GO:0032870 109 74 6,000 4,293E-06 2,669E-04 ! triglyceride metabolic process GO:0006641 34 28 4,000 4,418E-06 2,674E-04 ! positive regulation of secretion GO:0051047 71 51 5,000 5,927E-06 3,496E-04 ! positive regulation of protein modification process GO:0031401 107 78 6,000 6,117E-06 3,517E-04 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 2,000 6,88E-06 3,859E-04 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! substrate-bound cell migration, cell extension GO:0006930 5 5 2,000 6,88E-06 3,767E-04 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 6,88E-06 3,68E-04 ! alcohol catabolic process GO:0046164 104 80 6,000 7,247E-06 3,788E-04 ! mammary gland development GO:0030879 57 31 4,000 7,475E-06 3,82E-04 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 7,714E-06 3,857E-04 ! negative regulation of cell cycle process GO:0010948 24 15 3,000 7,714E-06 3,775E-04 ! regulation of cell cycle process GO:0010564 122 81 6,000 7,874E-06 3,773E-04 ! neutral lipid metabolic process GO:0006638 41 32 4,000 8,795E-06 4,128E-04 GO:0006639|acylglycerol metabolic process, ! regulation of cell adhesion GO:0030155 159 83 6,000 9,262E-06 4,261E-04 ! neutrophil chemotaxis GO:0030593 21 16 3,000 1,021E-05 4,606E-04 ! carbohydrate homeostasis GO:0033500 39 33 4,000 1,029E-05 4,552E-04 GO:0042593|glucose homeostasis, ! negative regulation of protein kinase activity GO:0006469 99 57 5,000 1,143E-05 4,959E-04 ! cell cycle arrest GO:0007050 150 86 6,000 1,172E-05 4,993E-04 ! glycerol ether metabolic process GO:0006662 44 34 4,000 1,198E-05 5,01E-04 ! negative regulation of kinase activity GO:0033673 100 58 5,000 1,265E-05 5,197E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 3,000 1,326E-05 5,352E-04 ! inactivation of MAPK activity GO:0000188 27 17 3,000 1,326E-05 5,26E-04 ! cell-substrate junction assembly GO:0007044 39 17 3,000 1,326E-05 5,171E-04 ! spindle checkpoint GO:0031577 14 6 2,000 1,367E-05 5,24E-04 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 1,367E-05 5,154E-04 ! activation of MAPK activity GO:0000187 84 59 5,000 1,398E-05 5,187E-04 ! regulation of hormone secretion GO:0046883 48 36 4,000 1,6E-05 5,841E-04 ! organic ether metabolic process GO:0018904 46 36 4,000 1,6E-05 5,75E-04 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 3,000 1,694E-05 5,992E-04 ! negative regulation of transferase activity GO:0051348 105 61 5,000 1,698E-05 5,917E-04 ! carbohydrate catabolic process GO:0016052 121 93 6,000 1,962E-05 6,735E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 5,000 2,048E-05 6,926E-04 ! apoptotic nuclear changes GO:0030262 24 19 3,000 2,13E-05 7,101E-04 ! positive regulation of intracellular transport GO:0032388 29 19 3,000 2,13E-05 6,999E-04 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 5,000 2,243E-05 7,266E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 2,376E-05 7,591E-04 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 2,376E-05 7,487E-04 ! JNK cascade GO:0007254 54 39 4,000 2,391E-05 7,432E-04 ! developmental growth GO:0048589 62 39 4,000 2,391E-05 7,333E-04 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 4,000 2,713E-05 8,211E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 2,713E-05 8,105E-04 ! cell aging GO:0007569 32 21 3,000 3,244E-05 9,565E-04 ! positive regulation of phosphorylation GO:0042327 102 70 5,000 3,754E-05 1,093E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 3,777E-05 1,086E-03 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 2,000 3,777E-05 1,073E-03 GO:0046579|positive regulation of Ras protein signal transduction, ! induction of positive chemotaxis GO:0050930 14 8 2,000 3,777E-05 1,059E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 3,777E-05 1,047E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 3,777E-05 1,034E-03 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 3,777E-05 1,022E-03 ! activation of caspase activity GO:0006919 65 43 4,000 3,885E-05 1,039E-03 ! protein import into nucleus, translocation GO:0000060 36 22 3,000 3,937E-05 1,041E-03 ! negative regulation of cell migration GO:0030336 92 44 4,000 4,351E-05 1,137E-03 ! regulation of peptidase activity GO:0052547 106 72 5,000 4,408E-05 1,139E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 4,733E-05 1,21E-03 ! response to UV GO:0009411 75 46 4,000 5,414E-05 1,368E-03 ! T cell selection GO:0045058 18 9 2,000 5,629E-05 1,407E-03 ! substrate-bound cell migration GO:0006929 10 9 2,000 5,629E-05 1,392E-03 ! alpha-beta T cell differentiation GO:0046632 14 9 2,000 5,629E-05 1,377E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 5,629E-05 1,363E-03 ! oocyte differentiation GO:0009994 12 9 2,000 5,629E-05 1,349E-03 GO:0048599|oocyte development, ! positive regulation of caspase activity GO:0043280 72 48 4,000 6,667E-05 1,581E-03 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 4,000 6,667E-05 1,565E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 6,668E-05 1,549E-03 GO:0045936|negative regulation of phosphate metabolic process, ! germ cell development GO:0007281 68 49 4,000 7,371E-05 1,695E-03 ! negative regulation of protein kinase cascade GO:0010741 51 26 3,000 7,826E-05 1,782E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 2,000 7,988E-05 1,801E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 2,000 7,988E-05 1,784E-03 ! alpha-beta T cell activation GO:0046631 16 10 2,000 7,988E-05 1,767E-03 ! negative regulation of cell motion GO:0051271 104 51 4,000 8,951E-05 1,961E-03 ! aging GO:0007568 79 52 4,000 9,833E-05 2,133E-03 ! cell junction assembly GO:0034329 56 28 3,000 1,057E-04 2,272E-03 ! positive regulation of multicellular organism growth GO:0040018 38 28 3,000 1,057E-04 2,251E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 3,000 1,057E-04 2,231E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 1,091E-04 2,282E-03 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 1,091E-04 2,261E-03 ! T cell homeostasis GO:0043029 20 11 2,000 1,091E-04 2,241E-03 ! digestive tract morphogenesis GO:0048546 15 11 2,000 1,091E-04 2,221E-03 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of glucose import GO:0046325 14 11 2,000 1,091E-04 2,202E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,091E-04 2,182E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of DNA metabolic process GO:0051052 135 85 5,000 1,122E-04 2,224E-03 ! regulation of mitosis GO:0007088 84 54 4,000 1,179E-04 2,319E-03 GO:0051783|regulation of nuclear division, ! regulation of protein import into nucleus GO:0042306 53 29 3,000 1,218E-04 2,374E-03 ! gland morphogenesis GO:0022612 23 12 2,000 1,445E-04 2,794E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,445E-04 2,77E-03 ! multicellular organism reproduction GO:0032504 83 57 4,000 1,528E-04 2,905E-03 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 4,000 1,528E-04 2,881E-03 ! developmental maturation GO:0021700 75 57 4,000 1,528E-04 2,858E-03 ! negative regulation of secretion GO:0051048 49 31 3,000 1,591E-04 2,951E-03 ! leukocyte chemotaxis GO:0030595 43 31 3,000 1,591E-04 2,928E-03 GO:0060326|cell chemotaxis, ! regulation of ARF protein signal transduction GO:0032012 51 32 3,000 1,806E-04 3,296E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,867E-04 3,381E-03 ! negative regulation of mitotic cell cycle GO:0045930 23 13 2,000 1,867E-04 3,354E-03 ! lymphocyte homeostasis GO:0002260 24 13 2,000 1,867E-04 3,328E-03 ! negative regulation of cell adhesion GO:0007162 67 33 3,000 2,041E-04 3,61E-03 ! cell junction organization GO:0034330 63 33 3,000 2,041E-04 3,583E-03 ! nucleus organization GO:0006997 49 33 3,000 2,041E-04 3,556E-03 ! cell-matrix adhesion GO:0007160 114 61 4,000 2,11E-04 3,649E-03 ! regulation of cellular component biogenesis GO:0044087 158 96 5,000 2,194E-04 3,766E-03 ! response to light stimulus GO:0009416 153 96 5,000 2,194E-04 3,738E-03 ! inositol metabolic process GO:0006020 20 14 2,000 2,36E-04 3,992E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 2,36E-04 3,963E-03 GO:0060675|ureteric bud morphogenesis, ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 2,36E-04 3,934E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 2,647E-04 4,38E-03 ! regulation of caspase activity GO:0043281 97 65 4,000 2,847E-04 4,677E-03 ! hormone-mediated signaling GO:0009755 49 36 3,000 2,877E-04 4,693E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 2,931E-04 4,748E-03 ! cardiac muscle tissue development GO:0048738 23 15 2,000 2,931E-04 4,714E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 2,931E-04 4,682E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 2,931E-04 4,649E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 2,931E-04 4,618E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 2,931E-04 4,586E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! cell-substrate adhesion GO:0031589 121 66 4,000 3,059E-04 4,753E-03 ! regulation of endopeptidase activity GO:0052548 99 67 4,000 3,282E-04 5,066E-03 ! regulation of T cell proliferation GO:0042129 58 38 3,000 3,556E-04 5,452E-03 ! pigmentation GO:0043473 74 38 3,000 3,556E-04 5,416E-03 ! endothelial cell migration GO:0043542 22 16 2,000 3,584E-04 5,423E-03 ! oogenesis GO:0048477 23 16 2,000 3,584E-04 5,388E-03 ! branched chain family amino acid metabolic process GO:0009081 24 16 2,000 3,584E-04 5,353E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 3,935E-04 5,839E-03 ! regulation of viral genome replication GO:0045069 24 17 2,000 4,324E-04 6,375E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 4,324E-04 6,334E-03 ! proximal/distal pattern formation GO:0009954 25 17 2,000 4,324E-04 6,294E-03 ! positive regulation of protein transport GO:0051222 55 40 3,000 4,342E-04 6,281E-03 ! response to hypoxia GO:0001666 132 72 4,000 4,587E-04 6,594E-03 ! negative regulation of organelle organization GO:0010639 115 72 4,000 4,587E-04 6,553E-03 ! regulation of T cell differentiation GO:0045580 59 41 3,000 4,778E-04 6,784E-03 ! mitochondrion organization GO:0007005 104 73 4,000 4,89E-04 6,9E-03 ! regulation of glucose import GO:0046324 21 18 2,000 5,154E-04 7,229E-03 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 2,000 5,154E-04 7,185E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 5,154E-04 7,142E-03 ! response to oxygen levels GO:0070482 137 74 4,000 5,207E-04 7,171E-03 ! protein import into nucleus GO:0006606 118 74 4,000 5,207E-04 7,128E-03 ! regulation of JAK-STAT cascade GO:0046425 61 42 3,000 5,245E-04 7,138E-03 ! cellular component disassembly GO:0022411 64 42 3,000 5,245E-04 7,096E-03 ! nuclear import GO:0051170 121 75 4,000 5,539E-04 7,45E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 5,743E-04 7,679E-03 ! leukocyte migration GO:0050900 60 43 3,000 5,743E-04 7,635E-03 ! epithelial tube morphogenesis GO:0060562 65 43 3,000 5,743E-04 7,591E-03 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 6,081E-04 7,992E-03 ! response to alkaloid GO:0043279 32 19 2,000 6,081E-04 7,947E-03 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 2,000 6,081E-04 7,902E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 6,081E-04 7,857E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 6,081E-04 7,813E-03 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 6,273E-04 8,016E-03 ! positive regulation of cell cycle GO:0045787 77 45 3,000 6,838E-04 8,689E-03 ! cell maturation GO:0048469 60 45 3,000 6,838E-04 8,642E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 6,838E-04 8,594E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 7,107E-04 8,884E-03 ! positive regulation of locomotion GO:0040017 35 20 2,000 7,107E-04 8,836E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 2,000 7,107E-04 8,789E-03 ! protein localization in nucleus GO:0034504 133 80 4,000 7,444E-04 9,156E-03 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 1,000 7,774E-04 9,51E-03 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 1,000 7,774E-04 9,46E-03 ! SMAD protein complex assembly GO:0007183 9 5 1,000 7,774E-04 9,41E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 7,774E-04 9,361E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 7,774E-04 9,312E-03 ! anagen GO:0042640 6 5 1,000 7,774E-04 9,264E-03 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 7,774E-04 9,216E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 7,774E-04 9,169E-03 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 7,774E-04 9,122E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 7,774E-04 9,076E-03 ! valine metabolic process GO:0006573 8 5 1,000 7,774E-04 9,03E-03 ! response to food GO:0032094 5 5 1,000 7,774E-04 8,985E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 7,774E-04 8,94E-03 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 7,774E-04 8,895E-03 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 7,774E-04 8,851E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 7,774E-04 8,808E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 7,774E-04 8,764E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 7,774E-04 8,722E-03 ! centrosome duplication GO:0051298 5 5 1,000 7,774E-04 8,679E-03 ! response to UV-C GO:0010225 6 5 1,000 7,774E-04 8,637E-03 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 7,774E-04 8,596E-03 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 1,000 7,774E-04 8,555E-03 ! positive regulation of mast cell activation GO:0033005 5 5 1,000 7,774E-04 8,514E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 1,000 7,774E-04 8,474E-03 GO:0031272|regulation of pseudopodium assembly, ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 7,774E-04 8,434E-03 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 7,774E-04 8,394E-03 GO:0007439|ectodermal gut development, ! somatic stem cell maintenance GO:0035019 13 5 1,000 7,774E-04 8,355E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 7,774E-04 8,316E-03 ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 7,774E-04 8,278E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 8,074E-04 8,557E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 2,000 8,238E-04 8,691E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 8,238E-04 8,652E-03 ! regulation of chemotaxis GO:0050920 36 21 2,000 8,238E-04 8,612E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 8,747E-04 9,103E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 3,000 8,747E-04 9,062E-03 ! regulation of lymphocyte differentiation GO:0045619 69 48 3,000 8,747E-04 9,022E-03 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 2,000 9,476E-04 9,73E-03 ! molting cycle process GO:0022404 40 22 2,000 9,476E-04 9,687E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! vasculogenesis GO:0001570 33 22 2,000 9,476E-04 9,644E-03 ! ureteric bud development GO:0001657 32 22 2,000 9,476E-04 9,602E-03 ! regulation of behavior GO:0050795 38 22 2,000 9,476E-04 9,56E-03 ! leukocyte homeostasis GO:0001776 33 22 2,000 9,476E-04 9,518E-03 ! regulation of membrane potential GO:0042391 128 85 4,000 9,802E-04 9,802E-03 ! ear development GO:0043583 72 50 3,000 1,021E-03 0,0101667 ! positive regulation of growth GO:0045927 67 50 3,000 1,021E-03 0,01012288 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 1,033E-03 0,01020001 ! neuron fate commitment GO:0048663 32 23 2,000 1,083E-03 0,01064181 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,083E-03 0,01059652 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 1,083E-03 0,01055162 ! negative regulation of DNA replication GO:0008156 35 23 2,000 1,083E-03 0,0105071 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 1,083E-03 0,01046295 ! regulation of viral reproduction GO:0050792 32 23 2,000 1,083E-03 0,01041918 ! regulation of protein catabolic process GO:0042176 77 51 3,000 1,1E-03 0,01054525 ! interphase GO:0051325 159 88 4,000 1,146E-03 0,01093608 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 1,159E-03 0,01101743 ! prostate gland development GO:0030850 9 6 1,000 1,159E-03 0,01097209 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 1,000 1,159E-03 0,01092712 GO:0046580|negative regulation of Ras protein signal transduction, ! male meiosis GO:0007140 7 6 1,000 1,159E-03 0,01088252 ! erythrocyte maturation GO:0043249 6 6 1,000 1,159E-03 0,01083828 ! amyloid precursor protein catabolic process GO:0042987 9 6 1,000 1,159E-03 0,0107944 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 1,159E-03 0,01075088 ! pigment granule organization GO:0048753 11 6 1,000 1,159E-03 0,0107077 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,159E-03 0,01066487 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 1,159E-03 0,01062238 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 1,159E-03 0,01058023 ! positive regulation of exocytosis GO:0045921 6 6 1,000 1,159E-03 0,01053841 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 1,159E-03 0,01049692 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! DNA topological change GO:0006265 8 6 1,000 1,159E-03 0,01045575 ! positive regulation of B cell differentiation GO:0045579 9 6 1,000 1,159E-03 0,01041491 ! gas homeostasis GO:0033483 11 6 1,000 1,159E-03 0,01037439 ! hair follicle maturation GO:0048820 7 6 1,000 1,159E-03 0,01033418 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,159E-03 0,01029428 ! regulation of mast cell activation GO:0033003 6 6 1,000 1,159E-03 0,01025468 ! regulation of Rac protein signal transduction GO:0035020 8 6 1,000 1,159E-03 0,01021539 ! blastocyst growth GO:0001832 15 6 1,000 1,159E-03 0,0101764 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,159E-03 0,01013771 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 1,159E-03 0,01009931 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 1,159E-03 0,0100612 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 1,229E-03 0,01062929 ! iron ion homeostasis GO:0055072 39 25 2,000 1,388E-03 0,01195516 ! regulation of chromosome organization GO:0033044 35 25 2,000 1,388E-03 0,01191056 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 1,388E-03 0,01186628 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,388E-03 0,01182233 ! cell fate commitment GO:0045165 141 92 4,000 1,398E-03 0,01186553 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 1,467E-03 0,01240501 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,559E-03 0,01313151 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 1,559E-03 0,01308358 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,613E-03 0,01349397 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,613E-03 0,01344508 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 1,613E-03 0,01339654 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,613E-03 0,01334835 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,613E-03 0,01330051 ! spinal cord patterning GO:0021511 7 7 1,000 1,613E-03 0,01325301 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,613E-03 0,01320584 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,613E-03 0,01315901 ! behavioral fear response GO:0001662 13 7 1,000 1,613E-03 0,01311252 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,613E-03 0,01306634 ! response to UV-B GO:0010224 11 7 1,000 1,613E-03 0,0130205 ! B cell lineage commitment GO:0002326 17 7 1,000 1,613E-03 0,01297497 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 1,613E-03 0,01292976 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,613E-03 0,01288487 ! T cell lineage commitment GO:0002360 12 7 1,000 1,613E-03 0,01284028 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,613E-03 0,01279601 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,613E-03 0,01275203 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 1,613E-03 0,01270836 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 1,669E-03 0,01310031 ! response to ionizing radiation GO:0010212 47 27 2,000 1,742E-03 0,01362851 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,742E-03 0,01358231 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 1,742E-03 0,01353643 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 2,000 1,742E-03 0,01349085 ! negative regulation of protein transport GO:0051224 49 27 2,000 1,742E-03 0,01344558 ! actin filament organization GO:0007015 95 59 3,000 1,897E-03 0,01458886 ! protein import GO:0017038 156 99 4,000 1,935E-03 0,01483191 ! response to organic cyclic substance GO:0014070 47 28 2,000 1,938E-03 0,01481203 ! positive regulation of catabolic process GO:0009896 40 28 2,000 1,938E-03 0,01476298 ! regulation of B cell activation GO:0050864 42 28 2,000 1,938E-03 0,01471426 ! regulation of heart contraction GO:0008016 91 60 3,000 2,018E-03 0,0152684 ! protein localization in organelle GO:0033365 161 100 4,000 2,022E-03 0,01524785 ! N-glycan processing GO:0006491 12 8 1,000 2,139E-03 0,01607461 ! succinate metabolic process GO:0006105 14 8 1,000 2,139E-03 0,01602225 ! smoothened signaling pathway GO:0007224 8 8 1,000 2,139E-03 0,01597023 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,139E-03 0,01591854 ! middle ear morphogenesis GO:0042474 9 8 1,000 2,139E-03 0,01586719 ! amyloid precursor protein metabolic process GO:0042982 12 8 1,000 2,139E-03 0,01581617 ! melanin metabolic process GO:0006582 12 8 1,000 2,139E-03 0,01576548 ! multicellular organism growth GO:0035264 14 8 1,000 2,139E-03 0,01571511 ! regulation of Notch signaling pathway GO:0008593 18 8 1,000 2,139E-03 0,01566506 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 2,139E-03 0,01561533 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,139E-03 0,01556592 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,139E-03 0,01551681 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 2,139E-03 0,01546802 ! negative regulation of DNA replication initiation GO:0032297 9 8 1,000 2,139E-03 0,01541953 GO:0000076|DNA replication checkpoint, ! meiosis GO:0007126 96 61 3,000 2,145E-03 0,01541643 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 3,000 2,145E-03 0,01536841 ! homeostasis of number of cells GO:0048872 84 61 3,000 2,145E-03 0,01532068 ! tissue homeostasis GO:0001894 42 29 2,000 2,148E-03 0,01529578 GO:0048871|multicellular organismal homeostasis, ! negative regulation of cell growth GO:0030308 106 62 3,000 2,277E-03 0,01616462 ! meiotic cell cycle GO:0051321 97 62 3,000 2,277E-03 0,01611488 ! spindle organization GO:0007051 37 30 2,000 2,371E-03 0,01672952 ! hindbrain development GO:0030902 45 30 2,000 2,371E-03 0,01667836 ! regulation of microtubule-based process GO:0032886 58 30 2,000 2,371E-03 0,01662751 ! negative regulation of cell activation GO:0050866 44 30 2,000 2,371E-03 0,01657698 ! response to heat GO:0009408 41 30 2,000 2,371E-03 0,01652674 ! metanephros development GO:0001656 58 31 2,000 2,608E-03 0,01812373 ! reproductive structure development GO:0048608 90 65 3,000 2,707E-03 0,01875497 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 2,734E-03 0,01888054 ! protein complex disassembly GO:0043241 17 9 1,000 2,734E-03 0,01882402 GO:0043624|cellular protein complex disassembly, ! ventral spinal cord development GO:0021517 11 9 1,000 2,734E-03 0,01876782 ! phosphagen metabolic process GO:0006599 12 9 1,000 2,734E-03 0,01871197 GO:0006600|creatine metabolic process, ! regulation of stress fiber formation GO:0051492 20 9 1,000 2,734E-03 0,01865644 ! receptor clustering GO:0043113 15 9 1,000 2,734E-03 0,01860125 ! motor axon guidance GO:0008045 14 9 1,000 2,734E-03 0,01854638 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 2,734E-03 0,01849183 ! DNA ligation GO:0006266 14 9 1,000 2,734E-03 0,0184376 ! erythrocyte development GO:0048821 11 9 1,000 2,734E-03 0,01838369 ! hindbrain morphogenesis GO:0021575 12 9 1,000 2,734E-03 0,01833009 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 2,734E-03 0,01827681 ! regulation of DNA replication initiation GO:0030174 13 9 1,000 2,734E-03 0,01822383 ! thymus development GO:0048538 15 9 1,000 2,734E-03 0,01817116 ! spleen development GO:0048536 15 9 1,000 2,734E-03 0,01811879 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 2,734E-03 0,01806673 ! sequestering of metal ion GO:0051238 11 9 1,000 2,734E-03 0,01801496 ! response to nicotine GO:0035094 16 9 1,000 2,734E-03 0,01796349 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 2,000 2,859E-03 0,01873667 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 2,859E-03 0,01868344 ! meiosis I GO:0007127 52 32 2,000 2,859E-03 0,01863052 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 2,859E-03 0,01857789 ! axon guidance GO:0007411 99 66 3,000 2,862E-03 0,01854362 ! regulation of Rho protein signal transduction GO:0035023 111 66 3,000 2,862E-03 0,01849153 ! female gonad development GO:0008585 49 33 2,000 3,125E-03 0,02013248 ! negative regulation of DNA binding GO:0043392 54 33 2,000 3,125E-03 0,02007624 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 3,125E-03 0,02002032 ! cytokinesis GO:0000910 52 33 2,000 3,125E-03 0,01996471 ! neuron fate specification GO:0048665 11 10 1,000 3,397E-03 0,02164292 ! regulation of B cell proliferation GO:0030888 15 10 1,000 3,397E-03 0,02158313 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 3,397E-03 0,02152367 ! hair follicle morphogenesis GO:0031069 17 10 1,000 3,397E-03 0,02146454 ! regulation of cell projection assembly GO:0060491 20 10 1,000 3,397E-03 0,02140574 ! pathogenesis GO:0009405 13 10 1,000 3,397E-03 0,02134725 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 3,397E-03 0,02128908 ! glucan biosynthetic process GO:0009250 13 10 1,000 3,397E-03 0,02123123 GO:0005978|glycogen biosynthetic process, ! response to X-ray GO:0010165 16 10 1,000 3,397E-03 0,02117369 ! B cell proliferation GO:0042100 14 10 1,000 3,397E-03 0,02111647 ! fear response GO:0042596 16 10 1,000 3,397E-03 0,02105955 ! negative regulation of ossification GO:0030279 19 10 1,000 3,397E-03 0,02100294 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 3,397E-03 0,02094663 ! regulation of B cell differentiation GO:0045577 16 10 1,000 3,397E-03 0,02089062 ! cranial nerve development GO:0021545 12 10 1,000 3,397E-03 0,02083492 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 3,397E-03 0,0207795 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 3,397E-03 0,02072439 ! embryonic gut development GO:0048566 11 10 1,000 3,397E-03 0,02066956 ! regulation of actin filament bundle formation GO:0032231 21 10 1,000 3,397E-03 0,02061502 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 3,397E-03 0,02056077 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 2,000 3,405E-03 0,02055569 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 3,405E-03 0,02050188 ! female gamete generation GO:0007292 43 34 2,000 3,405E-03 0,02044835 ! polyol metabolic process GO:0019751 44 34 2,000 3,405E-03 0,0203951 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 3,405E-03 0,02034213 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 3,405E-03 0,02028943 ! regulation of catabolic process GO:0009894 106 70 3,000 3,543E-03 0,02105416 ! Notch signaling pathway GO:0007219 56 35 2,000 3,7E-03 0,02193406 ! negative regulation of binding GO:0051100 58 36 2,000 4,01E-03 0,0237119 ! neural tube development GO:0021915 50 36 2,000 4,01E-03 0,0236511 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 4,01E-03 0,02359062 GO:0046660|female sex differentiation, ! tube morphogenesis GO:0035239 118 73 3,000 4,12E-03 0,02417171 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 4,128E-03 0,02415665 ! regulation of mRNA processing GO:0050684 18 11 1,000 4,128E-03 0,02409534 ! plasma membrane organization GO:0007009 18 11 1,000 4,128E-03 0,02403434 ! mitotic spindle organization GO:0007052 15 11 1,000 4,128E-03 0,02397364 ! virus-host interaction GO:0019048 17 11 1,000 4,128E-03 0,02391326 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,128E-03 0,02385317 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 4,128E-03 0,02379339 GO:0000725|recombinational repair, ! detection of mechanical stimulus GO:0050982 15 11 1,000 4,128E-03 0,02373391 ! membrane protein proteolysis GO:0033619 18 11 1,000 4,128E-03 0,02367472 GO:0006509|membrane protein ectodomain proteolysis, ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 4,128E-03 0,02361583 ! stem cell development GO:0048864 29 11 1,000 4,128E-03 0,02355723 GO:0019827|stem cell maintenance, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 2,000 4,336E-03 0,02468513 ! negative regulation of growth GO:0045926 123 75 3,000 4,538E-03 0,02577043 ! mesenchymal cell development GO:0014031 64 38 2,000 4,677E-03 0,02649632 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 2,000 4,677E-03 0,02643122 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 4,924E-03 0,02775928 ! auditory receptor cell differentiation GO:0042491 25 12 1,000 4,924E-03 0,02769141 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 4,924E-03 0,02762387 ! glycoprotein catabolic process GO:0006516 19 12 1,000 4,924E-03 0,02755666 ! monoamine transport GO:0015844 13 12 1,000 4,924E-03 0,02748977 ! histone acetylation GO:0016573 23 12 1,000 4,924E-03 0,02742321 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 1,000 4,924E-03 0,02735697 ! sex differentiation GO:0007548 105 77 3,000 4,984E-03 0,02762025 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 5,407E-03 0,02989514 ! T cell differentiation GO:0030217 65 40 2,000 5,407E-03 0,02982345 ! double-strand break repair GO:0006302 67 40 2,000 5,407E-03 0,0297521 ! forebrain development GO:0030900 131 80 3,000 5,706E-03 0,03132191 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 5,786E-03 0,03168323 ! lipid localization GO:0010876 24 13 1,000 5,786E-03 0,03160797 GO:0019915|lipid storage, ! cell differentiation in spinal cord GO:0021515 16 13 1,000 5,786E-03 0,03153307 ! regulation of exocytosis GO:0017157 17 13 1,000 5,786E-03 0,03145852 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 5,786E-03 0,03138433 ! cellular pigmentation GO:0033059 24 13 1,000 5,786E-03 0,03131048 ! regulation of calcium-mediated signaling GO:0050848 18 13 1,000 5,786E-03 0,03123698 ! glucose transport GO:0015758 52 41 2,000 5,796E-03 0,03122116 ! hexose transport GO:0008645 54 42 2,000 6,202E-03 0,03332744 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 2,000 6,202E-03 0,03324975 ! vesicle organization GO:0016050 79 43 2,000 6,624E-03 0,03542998 ! response to insulin stimulus GO:0032868 63 43 2,000 6,624E-03 0,03534778 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 6,711E-03 0,03572755 ! regulation of S phase GO:0033261 18 14 1,000 6,711E-03 0,03564504 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 6,711E-03 0,03556291 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 6,711E-03 0,03548115 ! epidermis morphogenesis GO:0048730 29 14 1,000 6,711E-03 0,03539977 ! pituitary gland development GO:0021983 23 14 1,000 6,711E-03 0,03531877 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 6,711E-03 0,03523813 GO:0031114|regulation of microtubule depolymerization, ! embryo implantation GO:0007566 27 14 1,000 6,711E-03 0,03515786 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 6,711E-03 0,03507796 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 6,711E-03 0,03499842 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 6,773E-03 0,0352464 ! regulation of action potential GO:0001508 71 44 2,000 7,063E-03 0,03666831 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 7,063E-03 0,03658572 ! regulation of inflammatory response GO:0050727 60 44 2,000 7,063E-03 0,03650351 ! positive regulation of defense response GO:0031349 59 45 2,000 7,518E-03 0,03877133 ! skeletal muscle tissue development GO:0007519 123 87 3,000 7,655E-03 0,03939026 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 7,655E-03 0,03930234 ! metencephalon development GO:0022037 19 15 1,000 7,698E-03 0,03943227 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 7,698E-03 0,03934465 ! myoblast differentiation GO:0045445 27 15 1,000 7,698E-03 0,03925741 ! centrosome cycle GO:0007098 16 15 1,000 7,698E-03 0,03917056 ! positive regulation of proteolysis GO:0045862 19 15 1,000 7,698E-03 0,03908409 ! regulation of vasodilation GO:0042312 24 15 1,000 7,698E-03 0,038998 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 7,698E-03 0,03891229 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 7,698E-03 0,03882695 ! defense response to virus GO:0051607 27 15 1,000 7,698E-03 0,03874199 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 7,698E-03 0,0386574 ! anatomical structure homeostasis GO:0060249 136 88 3,000 7,965E-03 0,03991371 ! reproductive developmental process GO:0003006 127 89 3,000 8,284E-03 0,0414175 ! regulation of T cell activation GO:0050863 128 89 3,000 8,284E-03 0,04132766 ! response to estrogen stimulus GO:0043627 74 47 2,000 8,481E-03 0,04221989 ! negative regulation of immune system process GO:0002683 73 47 2,000 8,481E-03 0,0421287 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 8,481E-03 0,04203791 ! hormone metabolic process GO:0042445 121 90 3,000 8,61E-03 0,04258627 ! protein amino acid acetylation GO:0006473 28 16 1,000 8,746E-03 0,04316873 ! regulation of protein binding GO:0043393 27 16 1,000 8,746E-03 0,0430763 ! regulation of dephosphorylation GO:0035303 33 16 1,000 8,746E-03 0,04298425 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 8,746E-03 0,0428926 ! diencephalon development GO:0021536 25 16 1,000 8,746E-03 0,04280134 ! nerve development GO:0021675 18 16 1,000 8,746E-03 0,04271047 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 8,746E-03 0,04261998 ! inner ear receptor cell differentiation GO:0060113 30 16 1,000 8,746E-03 0,04252987 ! response to temperature stimulus GO:0009266 62 48 2,000 8,988E-03 0,04361148 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 9,512E-03 0,04605919 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 9,512E-03 0,04596243 ! cartilage development GO:0051216 70 49 2,000 9,512E-03 0,04586607 ! maintenance of location GO:0051235 84 49 2,000 9,512E-03 0,04577012 ! regulation of cytoskeleton organization GO:0051493 154 93 3,000 9,639E-03 0,04628314 ! signal complex assembly GO:0007172 29 17 1,000 9,855E-03 0,04722137 ! regulation of striated muscle contraction GO:0006942 20 17 1,000 9,855E-03 0,0471232 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 9,855E-03 0,04702543 ! cellular macromolecular complex disassembly GO:0034623 29 17 1,000 9,855E-03 0,04692807 ! actin filament bundle formation GO:0051017 26 17 1,000 9,855E-03 0,04683111 ! neuromuscular junction development GO:0007528 23 17 1,000 9,855E-03 0,04673455 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 9,855E-03 0,04663839 ! stem cell differentiation GO:0048863 36 17 1,000 9,855E-03 0,04654262 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 9,855E-03 0,04644725 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 9,855E-03 0,04635226 ! skeletal muscle fiber development GO:0048741 73 50 2,000 0,01005421 0,04719324 ! negative regulation of cytoskeleton organization GO:0051494 84 50 2,000 0,01005421 0,04709712 ! lipid modification GO:0030258 73 50 2,000 0,01005421 0,0470014 ! regulation of binding GO:0051098 151 95 3,000 0,01036763 0,04836825 ! muscle fiber development GO:0048747 74 51 2,000 0,01061383 0,0494166 ! positive regulation of cell migration GO:0030335 92 51 2,000 0,01061383 0,04931677 ! positive regulation of organelle organization GO:0010638 82 51 2,000 0,01061383 0,04921734 ! regulation of response to external stimulus GO:0032101 139 96 3,000 0,01074496 0,04972518 ! positive regulation of DNA replication GO:0045740 29 18 1,000 0,01102233 0,05090633 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 0,01102233 0,05080431 ! axis specification GO:0009798 26 18 1,000 0,01102233 0,0507027 ! mechanoreceptor differentiation GO:0042490 32 18 1,000 0,01102233 0,0506015 ! pancreas development GO:0031016 26 18 1,000 0,01102233 0,0505007 ! pigmentation during development GO:0048066 31 18 1,000 0,01102233 0,0504003 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 0,01102233 0,0503003 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 0,01102233 0,05020069 ! visual learning GO:0008542 35 18 1,000 0,01102233 0,05010148 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 0,01102233 0,05000266 ! activation of JUN kinase activity GO:0007257 23 18 1,000 0,01102233 0,04990423 ! skeletal system morphogenesis GO:0048705 78 53 2,000 0,01178634 0,0532585 ! kidney development GO:0001822 90 53 2,000 0,01178634 0,05315407 ! cell projection assembly GO:0030031 76 53 2,000 0,01178634 0,05305005 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 0,01192985 0,05359113 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 0,01224753 0,05491095 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 0,01224753 0,05480412 ! regeneration GO:0031099 32 19 1,000 0,01224753 0,05469771 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 0,01224753 0,0545917 ! renal system process GO:0003014 35 19 1,000 0,01224753 0,05448611 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 0,01224753 0,05438092 ! leukotriene biosynthetic process GO:0019370 26 19 1,000 0,01224753 0,05427614 GO:0043450|alkene biosynthetic process, ! embryonic organ morphogenesis GO:0048562 23 19 1,000 0,01224753 0,05417177 ! protein stabilization GO:0050821 26 19 1,000 0,01224753 0,05406779 ! cytokine-mediated signaling pathway GO:0019221 76 54 2,000 0,01239941 0,05463344 ! DNA catabolic process GO:0006308 67 54 2,000 0,01239941 0,05452898 ! spinal cord development GO:0021510 31 20 1,000 0,0135294 0,05938475 ! response to ethanol GO:0045471 37 20 1,000 0,0135294 0,05927164 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,0135294 0,05915896 ! chromosome condensation GO:0030261 31 20 1,000 0,0135294 0,0590467 ! regulation of ARF GTPase activity GO:0032312 31 20 1,000 0,0135294 0,05893487 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,0135294 0,05882346 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 0,0135294 0,05871247 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 0,01367962 0,05925257 ! positive regulation of cell motion GO:0051272 99 56 2,000 0,01367962 0,05914119 ! carbohydrate transport GO:0008643 74 57 2,000 0,01434688 0,06190961 ! gonad development GO:0008406 79 57 2,000 0,01434688 0,06179367 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01486683 0,06391347 ! gluconeogenesis GO:0006094 25 21 1,000 0,01486683 0,06379423 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01486683 0,06367543 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01486683 0,06355707 ! visual behavior GO:0007632 39 21 1,000 0,01486683 0,06343916 ! regulation of DNA recombination GO:0000018 40 21 1,000 0,01486683 0,06332168 ! ovarian follicle development GO:0001541 30 21 1,000 0,01486683 0,06320463 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 0,01486683 0,06308802 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01486683 0,06297183 ! leukotriene metabolic process GO:0006691 28 21 1,000 0,01486683 0,06285608 ! regulation of vasoconstriction GO:0019229 31 21 1,000 0,01486683 0,06274074 ! platelet activation GO:0030168 28 21 1,000 0,01486683 0,06262583 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 1,000 0,01486683 0,06251134 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01486683 0,06239727 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01486683 0,06228362 ! acetyl-CoA catabolic process GO:0046356 31 21 1,000 0,01486683 0,06217037 GO:0006099|tricarboxylic acid cycle, ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 0,01503234 0,0627484 ! lung development GO:0030324 94 59 2,000 0,01573604 0,06556682 ! leukocyte adhesion GO:0007159 38 22 1,000 0,01625875 0,06762227 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01625875 0,06750021 ! macromolecular complex disassembly GO:0032984 38 22 1,000 0,01625875 0,06737859 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01625875 0,06725741 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01625875 0,06713666 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01625875 0,06701634 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 0,01625875 0,06689645 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 0,01625875 0,066777 ! coenzyme catabolic process GO:0009109 33 22 1,000 0,01625875 0,06665796 ! membrane depolarization GO:0051899 35 22 1,000 0,01625875 0,06653936 ! regulation of blood coagulation GO:0030193 34 22 1,000 0,01625875 0,06642117 ! cellular alkene metabolic process GO:0043449 29 22 1,000 0,01625875 0,0663034 ! blastocyst development GO:0001824 37 22 1,000 0,01625875 0,06618605 ! neural tube closure GO:0001843 33 22 1,000 0,01625875 0,06606911 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 0,01625875 0,06595259 ! phosphoinositide metabolic process GO:0030384 87 60 2,000 0,01645804 0,06664345 ! regulation of homeostatic process GO:0032844 105 60 2,000 0,01645804 0,06652633 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01770409 0,07143754 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01770409 0,07131243 ! myelination GO:0042552 35 23 1,000 0,01770409 0,07118776 ! acetyl-CoA metabolic process GO:0006084 33 23 1,000 0,01770409 0,07106352 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,01770409 0,07093972 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01770409 0,07081634 ! interaction with host GO:0051701 37 23 1,000 0,01770409 0,0706934 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01770409 0,07057088 ! cell fate determination GO:0001709 45 23 1,000 0,01770409 0,07044878 ! spermatid development GO:0007286 33 23 1,000 0,01770409 0,07032711 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01770409 0,07020586 ! liver development GO:0001889 40 23 1,000 0,01770409 0,07008502 ! respiratory tube development GO:0030323 99 62 2,000 0,01795708 0,0709644 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,01873419 0,07390847 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,01873419 0,07378192 ! positive regulation of cell projection organization GO:0031346 39 24 1,000 0,01920179 0,07549423 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,01920179 0,0753654 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,01920179 0,07523701 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01920179 0,07510906 ! fat cell differentiation GO:0045444 37 24 1,000 0,01920179 0,07498154 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01920179 0,07485445 ! receptor metabolic process GO:0043112 37 24 1,000 0,01920179 0,07472779 ! response to toxin GO:0009636 38 24 1,000 0,01920179 0,07460156 ! primary neural tube formation GO:0014020 35 24 1,000 0,01920179 0,07447576 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,01920179 0,07435038 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01920179 0,07422542 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01920179 0,07410088 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,01920179 0,07397676 ! respiratory system development GO:0060541 100 64 2,000 0,01952973 0,07511436 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 0,02034373 0,07811447 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,02075083 0,07954486 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 0,02075083 0,07941251 ! male gonad development GO:0008584 33 25 1,000 0,02075083 0,07928059 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,02075083 0,07914911 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 1,000 0,02075083 0,07901807 GO:0032943|mononuclear cell proliferation, ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,02202711 0,08373942 ! post-embryonic development GO:0009791 42 26 1,000 0,02235018 0,08482742 ! spermatid differentiation GO:0048515 36 26 1,000 0,02235018 0,08468767 ! regulation of coagulation GO:0050818 39 26 1,000 0,02235018 0,08454838 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,02289651 0,08647287 ! response to drug GO:0042493 108 69 2,000 0,02378439 0,08967886 ! respiratory gaseous exchange GO:0007585 47 27 1,000 0,02399883 0,09033929 ! cofactor catabolic process GO:0051187 45 27 1,000 0,02399883 0,09019168 ! amine transport GO:0015837 101 70 2,000 0,02469074 0,09264063 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,02561555 0,09595402 ! muscle cell differentiation GO:0042692 104 71 2,000 0,02561555 0,09579799 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,02561555 0,09564248 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,02569578 0,09578655 ! icosanoid biosynthetic process GO:0046456 42 28 1,000 0,02569578 0,09563155 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,02569578 0,09547706 GO:0055092|sterol homeostasis, ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02569578 0,09532306 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,02569578 0,09516956 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,02569578 0,09501656 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02569578 0,09486404 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,02569578 0,09471202 ! placenta development GO:0001890 37 28 1,000 0,02569578 0,09456048 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02744006 0,10081811 ! ovulation cycle process GO:0022602 41 29 1,000 0,02744006 0,10065731 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,02744006 0,10049703 ! telencephalon development GO:0021537 52 29 1,000 0,02744006 0,10033726 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,02744006 0,10017799 ! eye morphogenesis GO:0048592 51 29 1,000 0,02744006 0,10001923 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,02752048 0,10015364 ! cholesterol transport GO:0030301 46 30 1,000 0,02923069 0,10620945 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,02923069 0,10604193 ! ovulation cycle GO:0042698 43 30 1,000 0,02923069 0,10587494 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02923069 0,10570847 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,02923069 0,10554252 ! response to nutrient GO:0007584 104 75 2,000 0,029499 0,10634436 ! odontogenesis GO:0042476 50 31 1,000 0,03106672 0,11182074 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,03106672 0,11164602 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,03106672 0,11147185 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,03106672 0,11129822 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 1,000 0,03106672 0,11112513 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03106672 0,11095257 ! cell fate specification GO:0001708 37 31 1,000 0,03106672 0,11078055 ! regulation of DNA binding GO:0051101 119 77 2,000 0,03155087 0,11233282 ! protein ubiquitination GO:0016567 125 77 2,000 0,03155087 0,1121592 ! carbohydrate biosynthetic process GO:0016051 97 77 2,000 0,03155087 0,11198612 ! regulation of muscle development GO:0048634 48 32 1,000 0,03294721 0,11676207 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,03294721 0,11658243 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,03294721 0,11640335 ! peripheral nervous system development GO:0007422 53 32 1,000 0,03294721 0,11622482 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,03294721 0,11604683 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,03294721 0,11586939 ! T cell activation GO:0042110 134 79 2,000 0,03367578 0,11825083 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,03487123 0,12226193 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,03487123 0,12207584 ! sister chromatid segregation GO:0000819 46 33 1,000 0,03487123 0,12189031 ! ear morphogenesis GO:0042471 42 33 1,000 0,03487123 0,12170535 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03487123 0,12152095 ! lipid homeostasis GO:0055088 55 33 1,000 0,03487123 0,1213371 ! regulation of proteolysis GO:0030162 50 33 1,000 0,03487123 0,12115382 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,03683786 0,12779349 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,03683786 0,12760103 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,03683786 0,12740915 ! aerobic respiration GO:0009060 47 34 1,000 0,03683786 0,12721784 ! embryonic organ development GO:0048568 45 34 1,000 0,03683786 0,12702711 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,03884621 0,13375191 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,03884621 0,13355198 ! maintenance of protein location GO:0045185 65 35 1,000 0,03884621 0,13335265 ! glycogen metabolic process GO:0005977 48 35 1,000 0,03884621 0,13315391 ! pigment metabolic process GO:0042440 61 35 1,000 0,03884621 0,13295577 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,03884621 0,13275821 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,03884621 0,13256124 ! regulation of defense response GO:0031347 117 84 2,000 0,03930501 0,13392818 ! transcription initiation GO:0006352 118 85 2,000 0,04048472 0,13774387 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,04048472 0,13754041 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,04048472 0,13733755 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,04089537 0,13852629 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,04089537 0,13832258 ! tissue remodeling GO:0048771 62 36 1,000 0,04089537 0,13811946 ! glucan metabolic process GO:0044042 49 36 1,000 0,04089537 0,13791694 GO:0006073|cellular glucan metabolic process, ! female pregnancy GO:0007565 130 87 2,000 0,04289748 0,1444571 ! protein amino acid N-linked glycosylation GO:0006487 49 37 1,000 0,04298448 0,14453845 ! learning GO:0007612 67 37 1,000 0,04298448 0,14432744 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04383304 0,14696208 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04383304 0,14674816 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04383304 0,14653487 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04383304 0,14632219 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04383304 0,14611013 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04383304 0,14589868 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04383304 0,14568784 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04383304 0,14547762 ! sleep GO:0030431 11 5 0,000 0,04383304 0,14526799 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04383304 0,14505897 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04383304 0,14485056 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04383304 0,14464274 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04383304 0,14443551 ! tongue development GO:0043586 6 5 0,000 0,04383304 0,14422888 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04383304 0,14402284 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04383304 0,14381739 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04383304 0,14361252 ! cobalt ion transport GO:0006824 9 5 0,000 0,04383304 0,14340823 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04383304 0,14320453 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04383304 0,1430014 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04383304 0,14279885 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04383304 0,14259687 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04383304 0,14239546 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04383304 0,14219462 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04383304 0,14199435 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04383304 0,14179464 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04383304 0,14159549 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04383304 0,1413969 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04383304 0,14119886 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04383304 0,14100138 ! malate metabolic process GO:0006108 7 5 0,000 0,04383304 0,14080445 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04383304 0,14060807 ! behavioral response to pain GO:0048266 7 5 0,000 0,04383304 0,14041224 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04383304 0,14021695 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04383304 0,1400222 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04383304 0,139828 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04383304 0,13963433 ! mating behavior GO:0007617 6 5 0,000 0,04383304 0,1394412 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04383304 0,1392486 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04383304 0,13905653 ! rhythmic behavior GO:0007622 12 5 0,000 0,04383304 0,138865 ! copulation GO:0007620 7 5 0,000 0,04383304 0,13867399 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04383304 0,1384835 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04383304 0,13829354 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04383304 0,13810409 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04383304 0,13791517 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04383304 0,13772676 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04383304 0,13753886 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04383304 0,13735148 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04383304 0,13716461 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04383304 0,13697824 ! response to protozoan GO:0001562 9 5 0,000 0,04383304 0,13679238 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,04383304 0,13660703 ! lymph vessel development GO:0001945 7 5 0,000 0,04383304 0,13642217 ! endochondral ossification GO:0001958 12 5 0,000 0,04383304 0,13623782 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04383304 0,13605396 ! parathyroid gland development GO:0060017 8 5 0,000 0,04383304 0,1358706 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04383304 0,13568774 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04383304 0,13550536 ! nuclear migration GO:0007097 10 5 0,000 0,04383304 0,13532347 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04383304 0,13514207 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04383304 0,13496116 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04383304 0,13478073 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04383304 0,13460078 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04383304 0,13442132 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04383304 0,13424233 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04383304 0,13406381 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04383304 0,13388577 ! ovulation GO:0030728 6 5 0,000 0,04383304 0,13370821 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04383304 0,13353111 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,04383304 0,13335448 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,04383304 0,13317832 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04383304 0,13300262 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04383304 0,13282739 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04383304 0,13265261 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04383304 0,1324783 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04383304 0,13230445 ! polyol catabolic process GO:0046174 7 5 0,000 0,04383304 0,13213104 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04383304 0,1319581 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04383304 0,1317856 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04383304 0,13161356 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04383304 0,13144197 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04383304 0,13127082 ! urea metabolic process GO:0019627 6 5 0,000 0,04383304 0,13110011 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04383304 0,13092985 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04383304 0,13076004 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04383304 0,13059066 ! neutrophil activation GO:0042119 5 5 0,000 0,04383304 0,13042172 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04383304 0,13025321 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04383304 0,13008514 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04383304 0,12991751 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04383304 0,12975031 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04383304 0,12958353 ! forebrain neuron development GO:0021884 7 5 0,000 0,04383304 0,12941719 ! melanosome organization GO:0032438 7 5 0,000 0,04383304 0,12925127 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04383304 0,12908577 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04383304 0,1289207 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04383304 0,12875605 ! nucleoside transport GO:0015858 6 5 0,000 0,04383304 0,12859182 ! nucleoside salvage GO:0043174 7 5 0,000 0,04383304 0,12842801 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04383304 0,12826461 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04383304 0,12810164 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04383304 0,12793907 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04383304 0,12777692 ! depyrimidination GO:0045008 8 5 0,000 0,04383304 0,12761517 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04383304 0,12745384 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04383304 0,12729291 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04383304 0,12713239 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04383304 0,12697228 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04383304 0,12681256 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04383304 0,12665325 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,04383304 0,12649434 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04383304 0,12633582 ! monocyte differentiation GO:0030224 8 5 0,000 0,04383304 0,12617771 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04383304 0,12601998 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04383304 0,12586266 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04383304 0,12570572 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04383304 0,12554917 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04383304 0,12539302 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04383304 0,12523725 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04383304 0,12508187 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04383304 0,12492687 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04383304 0,12477226 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04383304 0,12461803 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04383304 0,12446418 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04383304 0,12431071 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04383304 0,12415762 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04383304 0,1240049 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04383304 0,12385256 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04383304 0,1237006 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04383304 0,123549 ! neural tube patterning GO:0021532 6 5 0,000 0,04383304 0,12339778 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04383304 0,12324693 ! histone demethylation GO:0016577 9 5 0,000 0,04383304 0,12309644 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04383304 0,12294633 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04383304 0,12279657 ! enteric nervous system development GO:0048484 8 5 0,000 0,04383304 0,12264719 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04383304 0,12249816 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04383304 0,1223495 ! transcription termination GO:0006353 8 5 0,000 0,04383304 0,1222012 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04383304 0,12205325 ! plasminogen activation GO:0031639 5 5 0,000 0,04383304 0,12190567 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,04383304 0,12175844 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04383304 0,12161156 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04383304 0,12146504 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04383304 0,12131888 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04383304 0,12117306 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04383304 0,1210276 ! apical protein localization GO:0045176 6 5 0,000 0,04383304 0,12088248 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04383304 0,12073771 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04383304 0,12059329 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04383304 0,12044921 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04383304 0,12030547 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04383304 0,12016208 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04383304 0,12001903 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04383304 0,11987632 ! glial cell migration GO:0008347 10 5 0,000 0,04383304 0,11973395 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04383304 0,11959192 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04383304 0,11945022 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04383304 0,11930886 ! neural plate development GO:0001840 6 5 0,000 0,04383304 0,11916783 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,04383304 0,11902714 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04383304 0,11888678 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04383304 0,11874675 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04383304 0,11860704 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04383304 0,11846767 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04383304 0,11832862 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04383304 0,1181899 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04383304 0,11805151 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04383304 0,11791344 ! spindle assembly GO:0051225 5 5 0,000 0,04383304 0,11777569 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04383304 0,11763826 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04383304 0,11750115 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04383304 0,11736436 ! organ regeneration GO:0031100 7 5 0,000 0,04383304 0,11722789 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04383304 0,11709174 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04383304 0,1169559 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04383304 0,11682038 GO:0055081|anion homeostasis, ! protein processing GO:0016485 114 88 2,000 0,04413038 0,1174767 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,04511266 0,11995274 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,04511266 0,11981423 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,04538085 0,12038749 ! leukocyte differentiation GO:0002521 143 90 2,000 0,04664882 0,12360861 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,04664882 0,12346637 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,04727907 0,12499064 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,04727907 0,12484714 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,04727907 0,12470396 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,04727907 0,12456112 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,04727907 0,1244186 ! male sex differentiation GO:0046661 53 39 1,000 0,04727907 0,12427641 ! cell growth GO:0016049 61 39 1,000 0,04727907 0,12413454 ! synapse organization GO:0050808 55 39 1,000 0,04727907 0,12399299 ! response to virus GO:0009615 122 91 2,000 0,04793419 0,12556793 ! glycerophospholipid metabolic process GO:0006650 130 92 2,000 0,04923689 0,12883372 ! DNA recombination GO:0006310 146 92 2,000 0,04923689 0,12868732 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,04948285 0,12918339 ! inner ear development GO:0048839 57 40 1,000 0,04948285 0,12903692 ! B cell differentiation GO:0030183 62 40 1,000 0,04948285 0,12889079 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,04948285 0,12874498 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,05172319 0,13442185 ! endosome transport GO:0016197 71 41 1,000 0,05172319 0,13427014 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,05172319 0,13411876 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,05172319 0,13396773 ! tRNA transcription GO:0009304 11 6 0,000 0,0523678 0,13548475 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,0523678 0,13533252 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,0523678 0,13518063 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,0523678 0,13502908 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,0523678 0,13487787 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,0523678 0,134727 ! regulation of helicase activity GO:0051095 11 6 0,000 0,0523678 0,13457647 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,0523678 0,13442627 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,0523678 0,13427641 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,0523678 0,13412688 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,0523678 0,13397769 ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,0523678 0,13382882 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,0523678 0,13368029 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,0523678 0,13353209 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,0523678 0,13338421 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,0523678 0,13323666 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,0523678 0,13308944 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,0523678 0,13294254 ! neuron adhesion GO:0007158 9 6 0,000 0,0523678 0,13279597 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,0523678 0,13264972 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,0523678 0,13250379 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,0523678 0,13235818 ! signal peptide processing GO:0006465 8 6 0,000 0,0523678 0,13221289 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,0523678 0,13206792 ! mRNA stabilization GO:0048255 15 6 0,000 0,0523678 0,13192327 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,0523678 0,13177893 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,0523678 0,13163491 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,0523678 0,1314912 ! opsonization GO:0008228 8 6 0,000 0,0523678 0,13134781 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,0523678 0,13120473 GO:0042069|regulation of catecholamine metabolic process, ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,0523678 0,13106196 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,0523678 0,1309195 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,0523678 0,13077735 ! photoreceptor cell development GO:0042461 10 6 0,000 0,0523678 0,13063551 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,0523678 0,13049398 ! mechanosensory behavior GO:0007638 8 6 0,000 0,0523678 0,13035275 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,0523678 0,13021183 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,0523678 0,13007121 ! response to interferon-gamma GO:0034341 12 6 0,000 0,0523678 0,1299309 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,0523678 0,12979088 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,0523678 0,12965117 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,0523678 0,12951176 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,0523678 0,12937265 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,0523678 0,12923384 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,0523678 0,12909533 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,0523678 0,12895711 ! thymic T cell selection GO:0045061 12 6 0,000 0,0523678 0,12881919 ! protein lipoylation GO:0009249 10 6 0,000 0,0523678 0,12868156 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,0523678 0,12854423 ! drug transport GO:0015893 6 6 0,000 0,0523678 0,12840719 ! cysteine metabolic process GO:0006534 7 6 0,000 0,0523678 0,12827044 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,0523678 0,12813398 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,0523678 0,12799781 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,0523678 0,12786193 ! histidine metabolic process GO:0006547 6 6 0,000 0,0523678 0,12772634 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,0523678 0,12759104 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,0523678 0,12745602 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,0523678 0,12732129 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,0523678 0,12718684 ! adenohypophysis development GO:0021984 10 6 0,000 0,0523678 0,12705268 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,0523678 0,1269188 ! hyperosmotic response GO:0006972 8 6 0,000 0,0523678 0,1267852 ! microtubule nucleation GO:0007020 10 6 0,000 0,0523678 0,12665188 ! ER overload response GO:0006983 7 6 0,000 0,0523678 0,12651885 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,0523678 0,12638609 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,0523678 0,12625361 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,0523678 0,1261214 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,0523678 0,12598948 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,0523678 0,12585783 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,0523678 0,12572645 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,0523678 0,12559535 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,0523678 0,12546452 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,0523678 0,12533397 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,0523678 0,12520368 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,0523678 0,12507367 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,0523678 0,12494392 ! neuron apoptosis GO:0051402 8 6 0,000 0,0523678 0,12481445 ! organic alcohol transport GO:0015850 9 6 0,000 0,0523678 0,12468524 ! T cell mediated immunity GO:0002456 12 6 0,000 0,0523678 0,1245563 ! male sex determination GO:0030238 9 6 0,000 0,0523678 0,12442763 ! carnitine transport GO:0015879 8 6 0,000 0,0523678 0,12429922 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,0523678 0,12417107 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,0523678 0,12404319 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0523678 0,12391558 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,0523678 0,12378822 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,0523678 0,12366113 ! parturition GO:0007567 12 6 0,000 0,0523678 0,1235343 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,0523678 0,12340773 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,0523678 0,12328141 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,0523678 0,12315536 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,0523678 0,12302956 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,0523678 0,12290402 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,0523678 0,12277874 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,0523678 0,12265371 ! macrophage differentiation GO:0030225 10 6 0,000 0,0523678 0,12252893 ! astrocyte development GO:0014002 14 6 0,000 0,0523678 0,12240441 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,0523678 0,12228014 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,0523678 0,12215613 ! interaction with symbiont GO:0051702 8 6 0,000 0,0523678 0,12203236 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,0523678 0,12190885 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,0523678 0,12178558 ! eating behavior GO:0042755 6 6 0,000 0,0523678 0,12166257 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,0523678 0,1215398 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,0523678 0,12141728 ! response to copper ion GO:0046688 9 6 0,000 0,0523678 0,12129501 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,0523678 0,12117298 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,0523678 0,1210512 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,0523678 0,12092966 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,0523678 0,12080837 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,0523678 0,12068732 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,0523678 0,12056651 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,0523678 0,12044594 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,0523678 0,12032562 ! Schwann cell development GO:0014044 14 6 0,000 0,0523678 0,12020553 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,0523678 0,12008568 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,0523678 0,11996608 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,0523678 0,11984671 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,0523678 0,11972758 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,0523678 0,11960868 ! histone ubiquitination GO:0016574 7 6 0,000 0,0523678 0,11949002 ! regulation of meiosis GO:0040020 10 6 0,000 0,0523678 0,1193716 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,0523678 0,11925341 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,0523678 0,11913545 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,0523678 0,11901773 ! membrane to membrane docking GO:0022614 12 6 0,000 0,0523678 0,11890024 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,0523678 0,11878298 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,0523678 0,11866595 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,0523678 0,11854915 ! receptor internalization GO:0031623 9 6 0,000 0,0523678 0,11843259 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,0523678 0,11831625 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,0523678 0,11820014 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0523678 0,11808426 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,0523678 0,1179686 ! protein deubiquitination GO:0016579 8 6 0,000 0,0523678 0,11785317 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,0523678 0,11773797 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,0523678 0,11762299 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,0523678 0,11750824 ! axonal fasciculation GO:0007413 9 6 0,000 0,0523678 0,1173937 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,0523678 0,1172794 ! thiamin metabolic process GO:0006772 6 6 0,000 0,0523678 0,11716531 ! midbrain development GO:0030901 6 6 0,000 0,0523678 0,11705145 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,0523678 0,11693781 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,0523678 0,11682439 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,0523678 0,11671118 ! progesterone metabolic process GO:0042448 8 6 0,000 0,0523678 0,1165982 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,0523678 0,11648544 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,0523678 0,11637289 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,0523678 0,11626056 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,0523678 0,11614845 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,0523678 0,11603655 ! adult feeding behavior GO:0008343 6 6 0,000 0,0523678 0,11592487 ! pigment granule transport GO:0051904 12 6 0,000 0,0523678 0,11581341 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,0523678 0,11570215 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,0523678 0,11559111 ! catecholamine transport GO:0051937 7 6 0,000 0,0523678 0,11548029 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,0523678 0,11536968 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,0523678 0,11525927 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,0523678 0,11514908 ! protein prenylation GO:0018342 10 6 0,000 0,0523678 0,1150391 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,0523678 0,11492933 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,0523678 0,11481977 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,0523678 0,11471042 ! angiogenesis GO:0001525 149 95 2,000 0,05324801 0,11652752 ! mitochondrial transport GO:0006839 60 42 1,000 0,05399926 0,11805922 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,05399926 0,1179471 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,05399926 0,1178352 ! regulation of cell shape GO:0008360 78 42 1,000 0,05399926 0,11772351 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,05399926 0,11761203 ! icosanoid metabolic process GO:0006690 61 42 1,000 0,05399926 0,11750076 ! in utero embryonic development GO:0001701 147 96 2,000 0,05461907 0,11873712 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,05461907 0,118625 ! protein maturation GO:0051604 129 96 2,000 0,05461907 0,11851308 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,05631026 0,12206747 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,05631026 0,12195253 ! methylation GO:0032259 64 43 1,000 0,05631026 0,12183781 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,05865538 0,12679265 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,05865538 0,12667359 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,05865538 0,12655476 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,05865538 0,12643615 ! Ras protein signal transduction GO:0007265 162 100 2,000 0,0602708 0,12979667 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06082687 0,13087165 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06082687 0,13074934 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06082687 0,13062726 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,06082687 0,1305054 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06082687 0,13038378 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06082687 0,13026238 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06082687 0,1301412 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06082687 0,13002025 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06082687 0,12989953 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06082687 0,12977903 ! reproductive behavior GO:0019098 12 7 0,000 0,06082687 0,12965875 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06082687 0,1295387 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,06082687 0,12941886 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06082687 0,12929925 ! oligopeptide transport GO:0006857 11 7 0,000 0,06082687 0,12917986 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06082687 0,12906069 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06082687 0,12894174 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,06082687 0,12882301 ! pericardium development GO:0060039 8 7 0,000 0,06082687 0,1287045 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06082687 0,12858621 ! fibril organization GO:0043206 13 7 0,000 0,06082687 0,12846813 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06082687 0,12835027 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06082687 0,12823262 ! lipoprotein transport GO:0042953 9 7 0,000 0,06082687 0,12811519 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06082687 0,12799798 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06082687 0,12788098 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06082687 0,12776419 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06082687 0,12764762 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06082687 0,12753126 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06082687 0,12741511 ! chemosensory behavior GO:0007635 9 7 0,000 0,06082687 0,12729917 ! microtubule bundle formation GO:0001578 8 7 0,000 0,06082687 0,12718345 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,06082687 0,12706793 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06082687 0,12695262 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06082687 0,12683753 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06082687 0,12672264 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06082687 0,12660796 ! reflex GO:0060004 12 7 0,000 0,06082687 0,12649348 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06082687 0,12637922 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06082687 0,12626515 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06082687 0,1261513 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06082687 0,12603765 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06082687 0,1259242 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06082687 0,12581096 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06082687 0,12569793 ! adrenal gland development GO:0030325 17 7 0,000 0,06082687 0,12558509 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06082687 0,12547246 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06082687 0,12536003 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06082687 0,1252478 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06082687 0,12513577 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06082687 0,12502394 ! endosome organization GO:0007032 10 7 0,000 0,06082687 0,12491231 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06082687 0,12480088 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06082687 0,12468965 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06082687 0,12457862 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06082687 0,12446779 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06082687 0,12435715 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06082687 0,12424671 ! galactose metabolic process GO:0006012 10 7 0,000 0,06082687 0,12413646 ! vesicle fusion GO:0006906 15 7 0,000 0,06082687 0,12402641 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06082687 0,12391656 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,06082687 0,12380689 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06082687 0,12369743 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06082687 0,12358815 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06082687 0,12347907 ! retinol metabolic process GO:0042572 9 7 0,000 0,06082687 0,12337019 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06082687 0,12326149 ! rRNA modification GO:0000154 12 7 0,000 0,06082687 0,12315299 ! protein heterooligomerization GO:0051291 10 7 0,000 0,06082687 0,12304467 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06082687 0,12293655 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,06082687 0,12282861 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06082687 0,12272087 ! intermediate filament organization GO:0045109 11 7 0,000 0,06082687 0,12261331 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06082687 0,12250595 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06082687 0,12239877 ! fibrinolysis GO:0042730 9 7 0,000 0,06082687 0,12229178 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06082687 0,12218497 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06082687 0,12207835 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06082687 0,12197192 ! response to tropane GO:0014073 13 7 0,000 0,06082687 0,12186567 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06082687 0,12175961 ! melanosome localization GO:0032400 10 7 0,000 0,06082687 0,12165373 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06082687 0,12154804 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06082687 0,12144253 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06082687 0,1213372 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06082687 0,12123205 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06082687 0,12112709 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06082687 0,12102231 ! mast cell activation GO:0045576 9 7 0,000 0,06082687 0,12091771 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06082687 0,12081329 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06082687 0,12070905 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06082687 0,12060499 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06082687 0,12050111 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06082687 0,12039741 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06082687 0,12029389 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06082687 0,12019054 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06082687 0,12008737 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06082687 0,11998438 ! response to tumor cell GO:0002347 12 7 0,000 0,06082687 0,11988157 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06082687 0,11977893 ! neuroblast proliferation GO:0007405 13 7 0,000 0,06082687 0,11967647 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06082687 0,11957418 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06082687 0,11947207 ! diuresis GO:0030146 12 7 0,000 0,06082687 0,11937013 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06082687 0,11926836 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06082687 0,11916677 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06082687 0,11906535 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06082687 0,11896411 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06082687 0,11886303 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06082687 0,11876213 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06082687 0,1186614 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06082687 0,11856084 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06082687 0,11846045 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06082687 0,11836023 ! lymph node development GO:0048535 9 7 0,000 0,06082687 0,11826018 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06082687 0,1181603 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06082687 0,11806058 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06082687 0,11796104 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06082687 0,11786166 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06082687 0,11776245 ! ATP catabolic process GO:0006200 10 7 0,000 0,06082687 0,11766341 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06082687 0,11756453 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,06082687 0,11746582 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06082687 0,11736727 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06082687 0,11726889 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06082687 0,11717068 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06082687 0,11707263 ! muscle adaptation GO:0043500 12 7 0,000 0,06082687 0,11697474 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06082687 0,11687702 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06082687 0,11677946 ! retina homeostasis GO:0001895 9 7 0,000 0,06082687 0,11668206 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06082687 0,11658483 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06082687 0,11648775 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06082687 0,11639084 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06082687 0,11629409 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06082687 0,1161975 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,06344489 0,12109814 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,06344489 0,12099773 ! regulation of ossification GO:0030278 71 46 1,000 0,06344489 0,12089748 ! histone modification GO:0016570 68 46 1,000 0,06344489 0,1207974 ! endocrine system development GO:0035270 83 47 1,000 0,06588775 0,12534476 ! covalent chromatin modification GO:0016569 75 47 1,000 0,06588775 0,12524117 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,06588775 0,12513775 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,06588775 0,1250345 ! chloride transport GO:0006821 67 48 1,000 0,06836166 0,12962227 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,06836166 0,1295155 ! heart morphogenesis GO:0003007 65 48 1,000 0,06836166 0,1294089 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0692109 0,13090878 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0692109 0,13080121 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0692109 0,13069382 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0692109 0,1305866 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0692109 0,13047957 ! associative learning GO:0008306 15 8 0,000 0,0692109 0,1303727 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0692109 0,13026602 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0692109 0,1301595 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,0692109 0,13005316 ! phosphate transport GO:0006817 10 8 0,000 0,0692109 0,129947 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0692109 0,129841 ! UTP metabolic process GO:0046051 8 8 0,000 0,0692109 0,12973518 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0692109 0,12962954 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0692109 0,12952406 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0692109 0,12941876 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0692109 0,12931362 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0692109 0,12920866 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0692109 0,12910387 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0692109 0,12899925 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0692109 0,12889479 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,0692109 0,12879051 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0692109 0,1286864 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0692109 0,12858245 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0692109 0,12847867 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0692109 0,12837506 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0692109 0,12827161 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0692109 0,12816833 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0692109 0,12806522 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0692109 0,12796228 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0692109 0,1278595 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0692109 0,12775688 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0692109 0,12765443 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0692109 0,12755214 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0692109 0,12745002 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,0692109 0,12734806 ! macrophage activation GO:0042116 12 8 0,000 0,0692109 0,12724626 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0692109 0,12714463 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0692109 0,12704315 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0692109 0,12694184 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0692109 0,12684069 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0692109 0,12673971 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0692109 0,12663888 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0692109 0,12653821 ! ruffle organization GO:0031529 11 8 0,000 0,0692109 0,12643771 ! osteoblast development GO:0002076 13 8 0,000 0,0692109 0,12633736 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0692109 0,12623717 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0692109 0,12613714 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0692109 0,12603727 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0692109 0,12593756 GO:0007351|tripartite regional subdivision, ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0692109 0,125838 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0692109 0,1257386 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0692109 0,12563936 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0692109 0,12554028 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,0692109 0,12544135 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,0692109 0,12534258 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0692109 0,12524396 ! segment specification GO:0007379 10 8 0,000 0,0692109 0,1251455 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0692109 0,12504719 ! cellular extravasation GO:0045123 11 8 0,000 0,0692109 0,12494904 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0692109 0,12485104 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0692109 0,12475319 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0692109 0,1246555 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0692109 0,12455796 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0692109 0,12446057 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0692109 0,12436334 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0692109 0,12426625 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0692109 0,12416932 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0692109 0,12407254 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0692109 0,12397591 ! icosanoid secretion GO:0032309 12 8 0,000 0,0692109 0,12387943 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0692109 0,1237831 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0692109 0,12368692 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0692109 0,12359089 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0692109 0,12349501 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0692109 0,12339928 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0692109 0,1233037 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0692109 0,12320826 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0692109 0,12311297 ! sterol catabolic process GO:0016127 9 8 0,000 0,0692109 0,12301783 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0692109 0,12292283 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0692109 0,12282799 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0692109 0,12273329 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0692109 0,12263873 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0692109 0,12254432 ! prophase GO:0051324 11 8 0,000 0,0692109 0,12245005 ! S phase GO:0051320 8 8 0,000 0,0692109 0,12235593 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0692109 0,12226196 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0692109 0,12216813 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0692109 0,12207444 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0692109 0,1219809 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0692109 0,1218875 ! hormone catabolic process GO:0042447 13 8 0,000 0,0692109 0,12179424 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0692109 0,12170112 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,0692109 0,12160815 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0692109 0,12151532 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0692109 0,12142263 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0692109 0,12133008 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0692109 0,12123768 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0692109 0,12114541 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0692109 0,12105329 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0692109 0,1209613 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0692109 0,12086945 ! regulation of embryonic development GO:0045995 16 8 0,000 0,0692109 0,12077775 ! mitochondrion localization GO:0051646 12 8 0,000 0,0692109 0,12068618 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,0692109 0,12059475 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,07086589 0,12338497 ! RNA elongation GO:0006354 62 49 1,000 0,07086589 0,12329164 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,07752057 0,13476742 ! regulation of developmental growth GO:0048638 13 9 0,000 0,07752057 0,13466564 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,07752057 0,134564 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07752057 0,13446252 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07752057 0,13436119 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07752057 0,13426002 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,07752057 0,13415899 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,07752057 0,13405812 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,07752057 0,1339574 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,07752057 0,13385683 ! GTP metabolic process GO:0046039 9 9 0,000 0,07752057 0,13375642 ! elastic fiber assembly GO:0048251 13 9 0,000 0,07752057 0,13365615 ! social behavior GO:0035176 14 9 0,000 0,07752057 0,13355603 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,07752057 0,13345606 ! artery development GO:0060840 19 9 0,000 0,07752057 0,13335625 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,07752057 0,13325658 ! regulation of glycolysis GO:0006110 15 9 0,000 0,07752057 0,13315706 ! response to pain GO:0048265 16 9 0,000 0,07752057 0,13305769 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,07752057 0,13295847 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,07752057 0,13285939 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,07752057 0,13276046 ! lung alveolus development GO:0048286 17 9 0,000 0,07752057 0,13266168 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07752057 0,13256305 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,07752057 0,13246456 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07752057 0,13236622 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,07752057 0,13226803 ! protein targeting to ER GO:0045047 19 9 0,000 0,07752057 0,13216998 ! endoderm development GO:0007492 12 9 0,000 0,07752057 0,13207208 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07752057 0,13197432 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07752057 0,1318767 ! arginine catabolic process GO:0006527 10 9 0,000 0,07752057 0,13177923 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,07752057 0,13168191 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,07752057 0,13158473 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,07752057 0,13148769 ! V(D)J recombination GO:0033151 12 9 0,000 0,07752057 0,13139079 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,07752057 0,13129404 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07752057 0,13119743 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07752057 0,13110096 ! mannose metabolic process GO:0006013 9 9 0,000 0,07752057 0,13100463 ! epithelial cell development GO:0002064 10 9 0,000 0,07752057 0,13090845 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07752057 0,1308124 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07752057 0,1307165 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,07752057 0,13062073 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07752057 0,13052511 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07752057 0,13042963 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07752057 0,13033429 ! blastoderm segmentation GO:0007350 11 9 0,000 0,07752057 0,13023908 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,07752057 0,13014402 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07752057 0,13004909 ! response to amine stimulus GO:0014075 13 9 0,000 0,07752057 0,1299543 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07752057 0,12985965 ! renal water homeostasis GO:0003091 14 9 0,000 0,07752057 0,12976514 ! postreplication repair GO:0006301 11 9 0,000 0,07752057 0,12967077 ! mRNA cleavage GO:0006379 13 9 0,000 0,07752057 0,12957653 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07752057 0,12948243 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,07752057 0,12938846 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07752057 0,12929464 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,07752057 0,12920094 ! acid secretion GO:0046717 14 9 0,000 0,07752057 0,12910739 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07752057 0,12901397 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07752057 0,12892068 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07752057 0,12882753 ! purine base metabolic process GO:0006144 18 9 0,000 0,07752057 0,12873451 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07752057 0,12864163 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,07752057 0,12854888 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,07752057 0,12845627 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07752057 0,12836379 ! detection of calcium ion GO:0005513 13 9 0,000 0,07752057 0,12827144 ! blastocyst formation GO:0001825 12 9 0,000 0,07752057 0,12817923 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07752057 0,12808714 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07752057 0,12799519 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07752057 0,12790337 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,07752057 0,12781169 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07752057 0,12772013 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07752057 0,12762871 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,07752057 0,12753741 ! prepulse inhibition GO:0060134 14 9 0,000 0,07752057 0,12744625 ! embryonic placenta development GO:0001892 12 9 0,000 0,07752057 0,12735522 ! insulin secretion GO:0030073 17 9 0,000 0,07752057 0,12726431 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07752057 0,12717354 ! nucleus localization GO:0051647 15 9 0,000 0,07752057 0,1270829 ! regulation of synapse organization GO:0050807 12 9 0,000 0,07752057 0,12699238 ! localization within membrane GO:0051668 15 9 0,000 0,07752057 0,12690199 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,07855325 0,12850105 ! establishment of organelle localization GO:0051656 85 52 1,000 0,07855325 0,12840972 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,08117156 0,13259559 ! amino acid transport GO:0006865 84 54 1,000 0,08381664 0,13681922 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,08381664 0,13672218 ! detection of external stimulus GO:0009581 66 54 1,000 0,08381664 0,13662529 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,08381664 0,13652853 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,08575652 0,13958952 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,08575652 0,1394908 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,08575652 0,13939222 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,08575652 0,13929378 ! thyroid gland development GO:0030878 19 10 0,000 0,08575652 0,13919548 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,08575652 0,13909731 ! synapsis GO:0007129 13 10 0,000 0,08575652 0,13899929 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,08575652 0,1389014 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,08575652 0,13880365 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,08575652 0,13870604 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,08575652 0,13860857 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,08575652 0,13851123 ! phospholipid efflux GO:0033700 16 10 0,000 0,08575652 0,13841403 ! hippocampus development GO:0021766 19 10 0,000 0,08575652 0,13831697 ! blood vessel remodeling GO:0001974 21 10 0,000 0,08575652 0,13822004 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,08575652 0,13812324 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,08575652 0,13802659 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,08575652 0,13793006 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,08575652 0,13783368 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,08575652 0,13773742 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,08575652 0,13764131 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,08575652 0,13754532 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,08575652 0,13744947 ! melanocyte differentiation GO:0030318 15 10 0,000 0,08575652 0,13735376 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,08575652 0,13725817 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,08575652 0,13716272 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,08575652 0,1370674 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,08575652 0,13697222 ! forebrain cell migration GO:0021885 17 10 0,000 0,08575652 0,13687716 ! lipid digestion GO:0044241 15 10 0,000 0,08575652 0,13678224 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,08575652 0,13668745 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,08575652 0,13659279 ! UV protection GO:0009650 14 10 0,000 0,08575652 0,13649826 ! entry into host cell GO:0030260 20 10 0,000 0,08575652 0,13640387 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,08575652 0,1363096 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,08575652 0,13621546 ! regulation of bone resorption GO:0045124 24 10 0,000 0,08575652 0,13612146 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,08575652 0,13602758 ! regulation of organ growth GO:0046620 11 10 0,000 0,08575652 0,13593383 ! response to dsRNA GO:0043331 18 10 0,000 0,08575652 0,13584022 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,08575652 0,13574673 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,08575652 0,13565336 ! embryonic axis specification GO:0000578 12 10 0,000 0,08575652 0,13556013 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,08575652 0,13546703 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,08575652 0,13537405 ! fucose catabolic process GO:0019317 16 10 0,000 0,08575652 0,1352812 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,08575652 0,13518848 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,08575652 0,13509589 ! protein sumoylation GO:0016925 12 10 0,000 0,08575652 0,13500342 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,08575652 0,13491108 ! zymogen activation GO:0031638 14 10 0,000 0,08575652 0,13481886 ! salivary gland development GO:0007431 22 10 0,000 0,08575652 0,13472677 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,08575652 0,13463481 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,08575652 0,13454297 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,08575652 0,13445126 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,08575652 0,13435967 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,08575652 0,1342682 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,08575652 0,13417687 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,08575652 0,13408565 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,08575652 0,13399456 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,08575652 0,13390359 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,08575652 0,13381275 ! detection of bacterium GO:0016045 10 10 0,000 0,08575652 0,13372203 ! activation of innate immune response GO:0002218 10 10 0,000 0,08575652 0,13363143 GO:0002758|innate immune response-activating signal transduction, ! cardiac cell differentiation GO:0035051 16 10 0,000 0,08575652 0,13354096 ! developmental induction GO:0031128 13 10 0,000 0,08575652 0,1334506 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,08575652 0,13336037 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,08575652 0,13327027 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,08575652 0,13318028 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,08918442 0,13841037 ! camera-type eye development GO:0043010 88 57 1,000 0,09190578 0,14253763 ! secondary metabolic process GO:0019748 84 57 1,000 0,09190578 0,14244158 ! rRNA transcription GO:0009303 17 11 0,000 0,09391941 0,1454644 ! respiratory burst GO:0045730 14 11 0,000 0,09391941 0,14536651 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,09391941 0,14526875 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,09391941 0,14517113 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,09391941 0,14507363 ! filopodium assembly GO:0046847 19 11 0,000 0,09391941 0,14497627 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,09391941 0,14487903 ! RNA polyadenylation GO:0043631 19 11 0,000 0,09391941 0,14478193 ! mating GO:0007618 14 11 0,000 0,09391941 0,14468495 ! T cell proliferation GO:0042098 20 11 0,000 0,09391941 0,14458811 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,09391941 0,14449139 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,09391941 0,14439481 ! bone resorption GO:0045453 16 11 0,000 0,09391941 0,14429835 ! regulated secretory pathway GO:0045055 14 11 0,000 0,09391941 0,14420203 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,09391941 0,14410583 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,09391941 0,14400976 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,09391941 0,14391381 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,09391941 0,143818 ! syncytium formation GO:0006949 15 11 0,000 0,09391941 0,14372231 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,09391941 0,14362675 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,09391941 0,14353132 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,09391941 0,14343601 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,09391941 0,14334083 ! adult heart development GO:0007512 11 11 0,000 0,09391941 0,14324578 ! temperature homeostasis GO:0001659 16 11 0,000 0,09391941 0,14315085 ! L-glutamate transport GO:0015813 16 11 0,000 0,09391941 0,14305605 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,09391941 0,14296137 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,09391941 0,14286682 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,09391941 0,1427724 ! protein homotetramerization GO:0051289 18 11 0,000 0,09391941 0,14267809 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,09391941 0,14258392 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,09391941 0,14248987 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,09391941 0,14239594 ! vasoconstriction GO:0042310 15 11 0,000 0,09391941 0,14230213 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,09391941 0,14220845 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,09391941 0,14211489 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,09391941 0,14202146 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,09391941 0,14192814 ! ribosome assembly GO:0042255 13 11 0,000 0,09391941 0,14183495 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,09391941 0,14174189 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,09391941 0,14164894 ! chromatin silencing GO:0006342 19 11 0,000 0,09391941 0,14155612 ! nucleosome positioning GO:0016584 13 11 0,000 0,09391941 0,14146342 ! regulation of isotype switching GO:0045191 19 11 0,000 0,09391941 0,14137083 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,09391941 0,14127838 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,09391941 0,14118604 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,09391941 0,14109382 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,09391941 0,14100172 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,09391941 0,14090974 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,09391941 0,14081788 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,09391941 0,14072615 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,09391941 0,14063453 ! male genitalia development GO:0030539 13 11 0,000 0,09391941 0,14054303 ! cholesterol efflux GO:0033344 19 11 0,000 0,09391941 0,14045165 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,09391941 0,14036039 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,09391941 0,14026924 ! germ cell migration GO:0008354 18 11 0,000 0,09391941 0,14017822 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,09391941 0,14008731 ! defense response to fungus GO:0050832 12 11 0,000 0,09391941 0,13999652 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,09391941 0,13990585 ! lysogeny GO:0030069 18 11 0,000 0,09391941 0,1398153 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,09391941 0,13972486 ! acrosome reaction GO:0007340 13 11 0,000 0,09391941 0,13963454 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,09391941 0,13954434 ! viral reproductive process GO:0022415 87 58 1,000 0,09465126 0,14054093 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,09465126 0,14045026 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,09465126 0,14035971 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,09742022 0,14437275 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,09742022 0,14427978 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,10021202 0,14831895 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,10021202 0,14822357 GO:0035113|embryonic appendage morphogenesis, ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,10021202 0,14812831 ! lactation GO:0007595 20 12 0,000 0,10200988 0,15068896 ! reproductive cellular process GO:0048610 14 12 0,000 0,10200988 0,15059224 ! tRNA modification GO:0006400 14 12 0,000 0,10200988 0,15049565 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,10200988 0,15039917 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,10200988 0,15030283 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,10200988 0,1502066 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,10200988 0,1501105 ! non-recombinational repair GO:0000726 19 12 0,000 0,10200988 0,15001452 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,10200988 0,14991867 ! peroxisomal transport GO:0043574 21 12 0,000 0,10200988 0,14982293 ! cartilage condensation GO:0001502 18 12 0,000 0,10200988 0,14972732 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,10200988 0,14963183 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,10200988 0,14953646 ! heart looping GO:0001947 15 12 0,000 0,10200988 0,14944122 ! palate development GO:0060021 15 12 0,000 0,10200988 0,14934609 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,10200988 0,14925109 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,10200988 0,14915621 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,10200988 0,14906144 ! arginine metabolic process GO:0006525 13 12 0,000 0,10200988 0,1489668 ! methionine metabolic process GO:0006555 13 12 0,000 0,10200988 0,14887228 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,10200988 0,14877788 ! Golgi organization GO:0007030 18 12 0,000 0,10200988 0,14868359 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,10200988 0,14858943 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,10200988 0,14849539 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,10200988 0,14840146 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,10200988 0,14830766 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,10200988 0,14821397 ! L-amino acid transport GO:0015807 20 12 0,000 0,10200988 0,1481204 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,10200988 0,14802695 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,10200988 0,14793361 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,10200988 0,1478404 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,10200988 0,1477473 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,10200988 0,14765432 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,10200988 0,14756145 ! cerebellum development GO:0021549 13 12 0,000 0,10200988 0,14746871 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,10200988 0,14737608 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,10200988 0,14728356 ! histone methylation GO:0016571 15 12 0,000 0,10200988 0,14719116 ! autonomic nervous system development GO:0048483 23 12 0,000 0,10200988 0,14709888 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,10200988 0,14700671 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,10200988 0,14691466 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,10200988 0,14682272 ! regulation of epidermis development GO:0045682 17 12 0,000 0,10200988 0,1467309 ! intestinal absorption GO:0050892 19 12 0,000 0,10200988 0,1466392 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,10200988 0,1465476 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,10200988 0,14645613 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,10200988 0,14636476 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,10200988 0,14627351 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,10200988 0,14618238 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,10200988 0,14609135 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,10200988 0,14600044 ! microspike assembly GO:0030035 23 12 0,000 0,10200988 0,14590965 ! response to cold GO:0009409 14 12 0,000 0,10200988 0,14581896 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,10302604 0,14718006 ! fatty acid biosynthetic process GO:0006633 92 61 1,000 0,10302604 0,1470887 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,10302604 0,14699745 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! organelle localization GO:0051640 96 62 1,000 0,10586167 0,15094969 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,10871831 0,15492696 ! viral reproduction GO:0016032 92 63 1,000 0,10871831 0,15483103 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,11002856 0,15660006 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11002856 0,15650321 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11002856 0,15640648 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,11002856 0,15630988 ! water transport GO:0006833 17 13 0,000 0,11002856 0,15621339 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11002856 0,15611702 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11002856 0,15602077 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11002856 0,15592464 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11002856 0,15582863 ! organelle fusion GO:0048284 28 13 0,000 0,11002856 0,15573273 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11002856 0,15563696 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11002856 0,1555413 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11002856 0,15544576 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11002856 0,15535033 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,11002856 0,15525503 ! glutamate metabolic process GO:0006536 18 13 0,000 0,11002856 0,15515984 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11002856 0,15506476 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,11002856 0,15496981 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,11002856 0,15487496 ! NAD metabolic process GO:0019674 21 13 0,000 0,11002856 0,15478024 ! exocrine system development GO:0035272 27 13 0,000 0,11002856 0,15468563 ! bone mineralization GO:0030282 15 13 0,000 0,11002856 0,15459114 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11002856 0,15449676 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11002856 0,1544025 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11002856 0,15430835 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11002856 0,15421432 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,11002856 0,1541204 ! genitalia development GO:0048806 15 13 0,000 0,11002856 0,15402659 ! regulation of cellular pH GO:0030641 20 13 0,000 0,11002856 0,1539329 ! tissue regeneration GO:0042246 21 13 0,000 0,11002856 0,15383933 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11002856 0,15374586 ! cofactor transport GO:0051181 19 13 0,000 0,11002856 0,15365252 ! NADP metabolic process GO:0006739 18 13 0,000 0,11002856 0,15355928 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11002856 0,15346616 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11002856 0,15337315 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11002856 0,15328025 ! gas transport GO:0015669 18 13 0,000 0,11002856 0,15318747 ! regulation of RNA stability GO:0043487 28 13 0,000 0,11002856 0,15309479 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11002856 0,15300223 ! regulation of axon extension GO:0030516 23 13 0,000 0,11002856 0,15290978 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,11002856 0,15281745 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11002856 0,15272522 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11002856 0,15263311 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11002856 0,1525411 ! appendage morphogenesis GO:0035107 93 64 1,000 0,11159536 0,15462008 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,11159536 0,15452699 ! appendage development GO:0048736 94 65 1,000 0,11449224 0,15844293 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 1,000 0,11449224 0,15834766 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,11449224 0,1582525 ! activation of immune response GO:0002253 83 65 1,000 0,11449224 0,15815745 ! protein oligomerization GO:0051259 100 65 1,000 0,11449224 0,15806252 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,11740837 0,16199115 ! regulation of immune effector process GO:0002697 101 66 1,000 0,11740837 0,16189403 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,1179761 0,16257941 ! superoxide anion generation GO:0042554 18 14 0,000 0,1179761 0,16248205 ! neuron maturation GO:0042551 21 14 0,000 0,1179761 0,16238482 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,1179761 0,1622877 ! myotube differentiation GO:0014902 21 14 0,000 0,1179761 0,16219069 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,1179761 0,16209381 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,1179761 0,16199703 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,1179761 0,16190038 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,1179761 0,16180383 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,1179761 0,16170741 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,1179761 0,1616111 ! gene silencing by RNA GO:0031047 20 14 0,000 0,1179761 0,1615149 ! response to cAMP GO:0051591 19 14 0,000 0,1179761 0,16141882 ! limbic system development GO:0021761 25 14 0,000 0,1179761 0,16132285 ! startle response GO:0001964 21 14 0,000 0,1179761 0,16122699 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,1179761 0,16113125 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,1179761 0,16103563 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,1179761 0,16094011 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,1179761 0,16084471 ! glycine metabolic process GO:0006544 22 14 0,000 0,1179761 0,16074943 ! cellular response to starvation GO:0009267 21 14 0,000 0,1179761 0,16065425 ! lysosomal transport GO:0007041 20 14 0,000 0,1179761 0,16055919 ! regulation of heart rate GO:0002027 23 14 0,000 0,1179761 0,16046424 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,1179761 0,1603694 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,1179761 0,16027468 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,1179761 0,16018007 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,1179761 0,16008556 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,1179761 0,15999117 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,1179761 0,15989689 ! axon cargo transport GO:0008088 27 14 0,000 0,1179761 0,15980273 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,1179761 0,15970867 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,1179761 0,15961472 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,1179761 0,15952089 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,1179761 0,15942716 ! mRNA splice site selection GO:0006376 26 14 0,000 0,1179761 0,15933355 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,1179761 0,15924004 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,1179761 0,15914665 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,1179761 0,15905336 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,1179761 0,15896018 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,1179761 0,15886711 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,1179761 0,15877415 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,1179761 0,1586813 ! muscle maintenance GO:0046716 19 14 0,000 0,1179761 0,15858856 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,1179761 0,15849593 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,1179761 0,1584034 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,1179761 0,15831099 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,1179761 0,15821868 ! cell killing GO:0001906 20 14 0,000 0,1179761 0,15812647 ! cilium assembly GO:0042384 20 14 0,000 0,1179761 0,15803438 ! peptide hormone secretion GO:0030072 23 14 0,000 0,1179761 0,15794239 ! learning or memory GO:0007611 123 68 1,000 0,1232961 0,16496861 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,1232961 0,1648727 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,1232961 0,1647769 ! rhythmic process GO:0048511 105 68 1,000 0,1232961 0,16468121 ! inorganic anion transport GO:0015698 93 68 1,000 0,1232961 0,16458563 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,12585312 0,16790149 ! positive regulation of cell size GO:0045793 20 15 0,000 0,12585312 0,16780416 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,12585312 0,16770693 ! skin development GO:0043588 25 15 0,000 0,12585312 0,16760983 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,12585312 0,16751283 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,12585312 0,16741594 ! lipid phosphorylation GO:0046834 23 15 0,000 0,12585312 0,16731917 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,12585312 0,16722251 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,12585312 0,16712596 ! bile acid metabolic process GO:0008206 22 15 0,000 0,12585312 0,16702953 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,12585312 0,1669332 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,12585312 0,16683698 ! adult walking behavior GO:0007628 25 15 0,000 0,12585312 0,16674088 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,12585312 0,16664489 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,12585312 0,166549 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,12585312 0,16645323 ! cerebral cortex development GO:0021987 29 15 0,000 0,12585312 0,16635757 ! response to osmotic stress GO:0006970 22 15 0,000 0,12585312 0,16626202 ! vesicle coating GO:0006901 25 15 0,000 0,12585312 0,16616657 ! DNA integration GO:0015074 22 15 0,000 0,12585312 0,16607124 ! peptide secretion GO:0002790 27 15 0,000 0,12585312 0,16597601 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,12585312 0,1658809 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,12585312 0,16578589 ! neuron recognition GO:0008038 22 15 0,000 0,12585312 0,165691 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,12585312 0,16559621 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,12585312 0,16550153 ! biomineral formation GO:0031214 18 15 0,000 0,12585312 0,16540695 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,12585312 0,16531249 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,12585312 0,16521813 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,12585312 0,16512388 ! dopamine metabolic process GO:0042417 30 15 0,000 0,12585312 0,16502974 ! organic cation transport GO:0015695 19 15 0,000 0,12585312 0,16493571 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,12585312 0,16484178 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,12585312 0,16474796 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,12585312 0,16465425 ! peptide hormone processing GO:0016486 19 15 0,000 0,12585312 0,16456064 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,1262666 0,16500749 ! response to metal ion GO:0010038 103 70 1,000 0,12925413 0,16881573 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,12925413 0,16871992 ! humoral immune response GO:0006959 86 70 1,000 0,12925413 0,16862422 ! eye development GO:0001654 111 70 1,000 0,12925413 0,16852863 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,12925413 0,16843314 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,13225814 0,17225013 ! protein secretion GO:0009306 27 16 0,000 0,13366023 0,17397767 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,13366023 0,17387926 ! hormone secretion GO:0046879 25 16 0,000 0,13366023 0,17378097 ! bone remodeling GO:0046849 24 16 0,000 0,13366023 0,17368279 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,13366023 0,17358472 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,13366023 0,17348676 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,13366023 0,17338891 ! glial cell development GO:0021782 24 16 0,000 0,13366023 0,17329117 ! patterning of blood vessels GO:0001569 24 16 0,000 0,13366023 0,17319354 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,13366023 0,17309602 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,13366023 0,17299861 ! protein polyubiquitination GO:0000209 26 16 0,000 0,13366023 0,17290131 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,13366023 0,17280412 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,13366023 0,17270704 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,13366023 0,17261007 ! fructose metabolic process GO:0006000 20 16 0,000 0,13366023 0,17251321 ! protein export from nucleus GO:0006611 24 16 0,000 0,13366023 0,17241645 ! negative regulation of immune response GO:0050777 28 16 0,000 0,13366023 0,17231981 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,13366023 0,17222327 ! DNA replication initiation GO:0006270 25 16 0,000 0,13366023 0,17212684 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,13366023 0,17203052 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,13366023 0,17193431 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,13366023 0,1718382 ! neural crest cell migration GO:0001755 24 16 0,000 0,13366023 0,1717422 ! G1 phase GO:0051318 27 16 0,000 0,13366023 0,17164631 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,13366023 0,17155052 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,13366023 0,17145485 ! steroid catabolic process GO:0006706 22 16 0,000 0,13366023 0,17135927 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,13366023 0,17126381 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,13366023 0,17116845 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,13366023 0,1710732 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,13366023 0,17097805 ! sperm-egg recognition GO:0035036 16 16 0,000 0,13366023 0,17088301 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,13366023 0,17078808 ! negative regulation of translation GO:0017148 22 16 0,000 0,13366023 0,17069325 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,13527813 0,17266353 ! phospholipid biosynthetic process GO:0008654 102 74 1,000 0,14136391 0,18033112 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,14136391 0,18023115 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,14139807 0,18017482 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,14139807 0,18007506 ! negative regulation of defense response GO:0031348 19 17 0,000 0,14139807 0,1799754 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,14139807 0,17987586 ! glycerol metabolic process GO:0006071 20 17 0,000 0,14139807 0,17977643 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,14139807 0,1796771 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,14139807 0,17957789 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,14139807 0,17947878 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,14139807 0,17937979 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,14139807 0,1792809 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,14139807 0,17918212 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,14139807 0,17908346 ! memory GO:0007613 25 17 0,000 0,14139807 0,1789849 ! keratinization GO:0031424 17 17 0,000 0,14139807 0,17888644 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,14139807 0,1787881 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,14139807 0,17868987 ! retinoid metabolic process GO:0001523 22 17 0,000 0,14139807 0,17859174 GO:0016101|diterpenoid metabolic process, ! DNA duplex unwinding GO:0032508 25 17 0,000 0,14139807 0,17849372 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,14139807 0,17839581 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,14139807 0,178298 ! membrane budding GO:0006900 29 17 0,000 0,14139807 0,1782003 ! heme metabolic process GO:0042168 27 17 0,000 0,14139807 0,17810271 ! body fluid secretion GO:0007589 27 17 0,000 0,14139807 0,17800523 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,14139807 0,17790785 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,14139807 0,17781058 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,14139807 0,17771342 ! sensory perception of pain GO:0019233 23 17 0,000 0,14139807 0,17761636 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,14139807 0,17751941 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,14139807 0,17742256 ! synaptogenesis GO:0007416 24 17 0,000 0,14139807 0,17732582 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,14139807 0,17722919 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,14139807 0,17713266 ! cell-cell junction organization GO:0045216 25 17 0,000 0,14139807 0,17703623 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,14139807 0,17693991 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,14139807 0,1768437 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,14139807 0,17674758 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,14139807 0,17665158 ! blood coagulation GO:0007596 116 75 1,000 0,14442871 0,18033986 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,14442871 0,18024201 ! regulation of ligase activity GO:0051340 114 75 1,000 0,14442871 0,18014426 ! amine biosynthetic process GO:0009309 97 76 1,000 0,14750743 0,18388461 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,14750743 0,18378499 ! positive regulation of translation GO:0045727 28 18 0,000 0,14906723 0,18562784 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,14906723 0,1855274 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,14906723 0,18542706 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,14906723 0,18532683 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,14906723 0,1852267 ! cAMP metabolic process GO:0046058 33 18 0,000 0,14906723 0,18512669 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,14906723 0,18502678 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,14906723 0,18492698 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,14906723 0,18482729 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,14906723 0,18472771 GO:0050886|endocrine process, ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,14906723 0,18462823 ! glutamine metabolic process GO:0006541 23 18 0,000 0,14906723 0,18452886 ! response to retinoic acid GO:0032526 25 18 0,000 0,14906723 0,1844296 ! central nervous system neuron development GO:0021954 30 18 0,000 0,14906723 0,18433044 ! fucose metabolic process GO:0006004 26 18 0,000 0,14906723 0,1842314 ! response to fungus GO:0009620 19 18 0,000 0,14906723 0,18413245 ! peptide cross-linking GO:0018149 31 18 0,000 0,14906723 0,18403362 ! heart process GO:0003015 27 18 0,000 0,14906723 0,18393489 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,14906723 0,18383626 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,14906723 0,18373774 ! somitogenesis GO:0001756 24 18 0,000 0,14906723 0,18363933 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,14906723 0,18354102 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,14906723 0,18344282 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,14906723 0,18334472 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,14906723 0,18324673 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,14906723 0,18314884 ! vitamin transport GO:0051180 24 18 0,000 0,14906723 0,18305106 ! hormone transport GO:0009914 27 18 0,000 0,14906723 0,18295338 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,14906723 0,1828558 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,14906723 0,18275833 ! cell-cell recognition GO:0009988 20 18 0,000 0,14906723 0,18266096 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,14906723 0,1825637 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,14906723 0,18246654 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,14906723 0,18236948 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,15059961 0,18414625 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,15059961 0,18404841 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,15059961 0,18395066 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,15370475 0,1876438 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,15666832 0,19116029 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,15666832 0,19105893 ! positive regulation of ossification GO:0045778 30 19 0,000 0,15666832 0,19095768 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,15666832 0,19085654 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,15666832 0,1907555 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,15666832 0,19065457 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,15666832 0,19055375 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,15666832 0,19045304 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,15666832 0,19035243 ! sensory perception of taste GO:0050909 23 19 0,000 0,15666832 0,19025192 ! smooth muscle contraction GO:0006939 36 19 0,000 0,15666832 0,19015153 ! peroxisome organization GO:0007031 29 19 0,000 0,15666832 0,19005124 ! digestive system process GO:0022600 30 19 0,000 0,15666832 0,18995105 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,15666832 0,18985097 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,15666832 0,189751 ! response to vitamin A GO:0033189 26 19 0,000 0,15666832 0,18965113 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,15666832 0,18955136 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,15666832 0,18945171 ! response to starvation GO:0042594 30 19 0,000 0,15666832 0,18935215 ! sex determination GO:0007530 29 19 0,000 0,15666832 0,1892527 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,15666832 0,18915336 ! plasma membrane fusion GO:0045026 23 19 0,000 0,15666832 0,18905412 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,15666832 0,18895498 ! cytolysis GO:0019835 20 19 0,000 0,15666832 0,18885595 ! vasodilation GO:0042311 33 19 0,000 0,15666832 0,18875702 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,15666832 0,18865819 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,15666832 0,18855947 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,15666832 0,18846085 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,15666832 0,18836233 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,15666832 0,18826392 ! sarcomere organization GO:0045214 23 19 0,000 0,15666832 0,18816561 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,15666832 0,1880674 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,15666832 0,1879693 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,15666832 0,18787129 ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,15666832 0,18777339 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,15666832 0,1876756 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,15682239 0,18776236 ! cellular respiration GO:0045333 107 79 1,000 0,15682239 0,18766467 ! regulation of lyase activity GO:0051339 133 79 1,000 0,15682239 0,18756708 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,15995205 0,19121087 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,16309328 0,1948647 ! hemostasis GO:0007599 125 81 1,000 0,16309328 0,19476352 ! mRNA transport GO:0051028 121 81 1,000 0,16309328 0,19466245 ! response to protein stimulus GO:0051789 111 81 1,000 0,16309328 0,19456149 ! regulation of neurological system process GO:0031644 122 81 1,000 0,16309328 0,19446063 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,16309328 0,19435987 GO:0002696|positive regulation of leukocyte activation, ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,16420195 0,19557974 ! iron ion transport GO:0006826 37 20 0,000 0,16420195 0,19547851 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,16420195 0,19537739 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,16420195 0,19527636 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,16420195 0,19517545 ! response to vitamin GO:0033273 29 20 0,000 0,16420195 0,19507463 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,16420195 0,19497392 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,16420195 0,19487332 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,16420195 0,19477281 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,16420195 0,19467242 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,16420195 0,19457212 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,16420195 0,19447193 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,16420195 0,19437184 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,16420195 0,19427186 ! pallium development GO:0021543 38 20 0,000 0,16420195 0,19417197 ! DNA modification GO:0006304 28 20 0,000 0,16420195 0,19407219 ! collagen fibril organization GO:0030199 45 20 0,000 0,16420195 0,19397252 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,16420195 0,19387294 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,16420195 0,19377347 ! collagen catabolic process GO:0030574 25 20 0,000 0,16420195 0,1936741 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,16420195 0,19357483 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,16420195 0,19347566 ! alditol metabolic process GO:0019400 24 20 0,000 0,16420195 0,19337659 ! actin filament-based movement GO:0030048 34 20 0,000 0,16420195 0,19327763 ! detection of stimulus GO:0051606 108 82 1,000 0,16624563 0,1955831 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,16940866 0,19920241 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,17166871 0,20175678 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,17166871 0,20165374 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,17166871 0,2015508 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,17166871 0,20144797 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,17166871 0,20134525 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,17166871 0,20124262 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,17166871 0,20114011 ! vesicle docking GO:0048278 27 21 0,000 0,17166871 0,20103769 ! phototransduction GO:0007602 25 21 0,000 0,17166871 0,20093538 ! dendrite development GO:0016358 35 21 0,000 0,17166871 0,20083318 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,17166871 0,20073108 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,17166871 0,20062908 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,17166871 0,20052718 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,17166871 0,20042539 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,17166871 0,20032371 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,17166871 0,20022212 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,17166871 0,20012064 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,17166871 0,20001926 ! fatty acid transport GO:0015908 30 21 0,000 0,17166871 0,19991799 ! immunoglobulin production GO:0002377 33 21 0,000 0,17166871 0,19981681 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,17166871 0,19971574 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,17166871 0,19961478 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,17166871 0,19951391 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,17166871 0,19941314 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,17166871 0,19931248 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,17166871 0,19921192 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,17166871 0,19911146 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,17166871 0,1990111 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,17166871 0,19891084 ! regulation of multi-organism process GO:0043900 32 21 0,000 0,17166871 0,19881069 ! rRNA metabolic process GO:0016072 107 85 1,000 0,17576498 0,20345217 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,17895743 0,2070433 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,17906918 0,20706844 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,17906918 0,20696438 ! viral genome replication GO:0019079 29 22 0,000 0,17906918 0,20686043 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,17906918 0,20675658 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,17906918 0,20665284 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,17906918 0,20654921 ! lysosome organization GO:0007040 37 22 0,000 0,17906918 0,20644567 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,17906918 0,20634224 GO:0051693|actin filament capping, ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,17906918 0,20623892 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,17906918 0,20613569 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,17906918 0,20603257 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,17906918 0,20592956 ! protein tetramerization GO:0051262 39 22 0,000 0,17906918 0,20582665 ! establishment of RNA localization GO:0051236 128 88 1,000 0,1853688 0,21296116 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! embryonic pattern specification GO:0009880 31 23 0,000 0,18640396 0,21404349 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,18640396 0,21393668 ! vesicle targeting GO:0006903 32 23 0,000 0,18640396 0,21382998 ! osteoblast differentiation GO:0001649 40 23 0,000 0,18640396 0,21372338 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,18640396 0,21361689 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,18640396 0,21351051 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,18640396 0,21340423 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,18640396 0,21329806 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,18640396 0,213192 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,18640396 0,21308604 ! pentose metabolic process GO:0019321 31 23 0,000 0,18640396 0,21298018 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,18640396 0,21287443 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,18640396 0,21276879 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,18640396 0,21266325 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,18640396 0,21255781 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,18640396 0,21245248 ! telomere organization GO:0032200 32 23 0,000 0,18640396 0,21234725 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,18640396 0,21224213 ! regulation of amine transport GO:0051952 38 23 0,000 0,18640396 0,21213711 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,18858692 0,21451529 ! initiation of viral infection GO:0019059 42 24 0,000 0,19367362 0,22019245 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,19367362 0,22008366 ! superoxide metabolic process GO:0006801 32 24 0,000 0,19367362 0,21997497 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,19367362 0,2198664 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,19367362 0,21975793 ! sperm motility GO:0030317 27 24 0,000 0,19367362 0,21964957 ! vacuole organization GO:0007033 39 24 0,000 0,19367362 0,21954131 ! neural crest cell development GO:0014032 39 24 0,000 0,19367362 0,21943316 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 56 24 0,000 0,19367362 0,21932512 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 0,000 0,19367362 0,21921719 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,19367362 0,21910936 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,19367362 0,21900163 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,19367362 0,21889402 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,19367362 0,2187865 ! RNA localization GO:0006403 135 91 1,000 0,19504601 0,22022868 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,19828621 0,22377737 ! positive regulation of immune response GO:0050778 121 92 1,000 0,19828621 0,22366762 ! sulfur metabolic process GO:0006790 118 92 1,000 0,19828621 0,22355798 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,20087873 0,22636996 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,20087873 0,2262591 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,20087873 0,22614835 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,20087873 0,22603771 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,20087873 0,22592718 ! peptide transport GO:0015833 43 25 0,000 0,20087873 0,22581676 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,20087873 0,22570644 ! phospholipid transport GO:0015914 35 25 0,000 0,20087873 0,22559623 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,20087873 0,22548613 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,20087873 0,22537614 ! detection of light stimulus GO:0009583 30 25 0,000 0,20087873 0,22526625 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,20153301 0,22588983 ! response to oxidative stress GO:0006979 141 94 1,000 0,20478604 0,2294242 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,20801988 0,23293365 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,20801988 0,2328203 ! translational initiation GO:0006413 43 26 0,000 0,20801988 0,23270706 ! regulation of pH GO:0006885 36 26 0,000 0,20801988 0,23259393 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,20801988 0,23248091 ! circadian rhythm GO:0007623 42 26 0,000 0,20801988 0,232368 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,20801988 0,2322552 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,20801988 0,23214251 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,20801988 0,23202993 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,20801988 0,23191746 GO:0046496|nicotinamide nucleotide metabolic process, ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,20801988 0,23180509 ! carboxylic acid transport GO:0046942 147 95 1,000 0,20804492 0,23172073 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,2113093 0,23524268 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,21457882 0,23876695 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,21457882 0,23865149 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,21509761 0,23911286 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,21509761 0,23899734 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,21509761 0,23888194 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,21509761 0,23876665 ! membrane docking GO:0022406 39 27 0,000 0,21509761 0,23865147 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,21509761 0,2385364 ! catechol metabolic process GO:0009712 43 27 0,000 0,21509761 0,23842145 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,21509761 0,2383066 ! acute-phase response GO:0006953 42 27 0,000 0,21509761 0,23819186 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,21509761 0,23807724 ! myofibril assembly GO:0030239 36 27 0,000 0,21509761 0,23796272 GO:0055002|striated muscle cell development, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,21509761 0,23784832 ! natural killer cell activation GO:0030101 35 27 0,000 0,21509761 0,23773402 ! lipid oxidation GO:0034440 38 27 0,000 0,21509761 0,23761984 GO:0019395|fatty acid oxidation, ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,21509761 0,23750576 ! gene silencing GO:0016458 41 27 0,000 0,21509761 0,23739179 ! calcium ion transport GO:0006816 167 99 1,000 0,2211319 0,24393447 ! extracellular structure organization GO:0043062 156 99 1,000 0,2211319 0,24381753 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,22211249 0,24478137 ! phenol metabolic process GO:0018958 44 28 0,000 0,22211249 0,24466414 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,22211249 0,24454702 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,22211249 0,24443001 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,22211249 0,24431312 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,22211249 0,24419633 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,22211249 0,24407966 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,22211249 0,2439631 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,22211249 0,24384665 ! mesoderm formation GO:0001707 46 28 0,000 0,22211249 0,24373031 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,22211249 0,24361408 ! BMP signaling pathway GO:0030509 40 28 0,000 0,22211249 0,24349796 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,22211249 0,24338196 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,22211249 0,24326606 ! regulation of translation GO:0006417 151 100 1,000 0,22441478 0,24567063 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,22441478 0,24555376 ! divalent metal ion transport GO:0070838 171 100 1,000 0,22441478 0,24543699 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,22441478 0,24532034 ! regulation of innate immune response GO:0045088 38 29 0,000 0,22906508 0,25028488 ! protein targeting to membrane GO:0006612 53 29 0,000 0,22906508 0,25016604 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,22906508 0,25004731 ! mismatch repair GO:0006298 34 29 0,000 0,22906508 0,24992869 ! muscle cell development GO:0055001 38 29 0,000 0,22906508 0,24981018 ! formation of primary germ layer GO:0001704 48 29 0,000 0,22906508 0,24969179 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,22906508 0,24957351 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,23595592 0,25695957 ! collagen metabolic process GO:0032963 40 30 0,000 0,23595592 0,25683796 ! organic anion transport GO:0015711 51 30 0,000 0,23595592 0,25671647 ! spliceosome assembly GO:0000245 49 30 0,000 0,23595592 0,25659509 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,23595592 0,25647382 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,23595592 0,25635268 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,23595592 0,25623164 ! ceramide metabolic process GO:0006672 43 30 0,000 0,23595592 0,25611072 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,23595592 0,25598991 ! adult locomotory behavior GO:0008344 47 30 0,000 0,23595592 0,25586922 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,23595592 0,25574864 ! glial cell differentiation GO:0010001 55 31 0,000 0,24278556 0,26302722 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,24278556 0,26290338 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,24278556 0,26277966 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,24278556 0,26265606 ! segmentation GO:0035282 41 31 0,000 0,24278556 0,26253257 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,24278556 0,2624092 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,24278556 0,26228595 ! RNA modification GO:0009451 40 31 0,000 0,24278556 0,26216281 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,24955454 0,26934558 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,24955454 0,26921925 ! cytokine production GO:0001816 44 32 0,000 0,24955454 0,26909303 ! vesicle localization GO:0051648 47 32 0,000 0,24955454 0,26896693 ! RNA export from nucleus GO:0006405 44 33 0,000 0,25626339 0,27606829 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,25626339 0,27593904 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,25626339 0,27580992 ! actomyosin structure organization GO:0031032 43 33 0,000 0,25626339 0,27568092 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,25626339 0,27555203 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,25626339 0,27542327 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,25626339 0,27529463 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,25626339 0,27516611 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,25626339 0,2750377 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,25626339 0,27490942 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,25626339 0,27478126 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,26291265 0,28177963 ! mRNA catabolic process GO:0006402 48 34 0,000 0,26291265 0,28164839 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,26291265 0,28151727 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,26291265 0,28138627 ! feeding behavior GO:0007631 45 34 0,000 0,26291265 0,28125539 ! neuron migration GO:0001764 46 34 0,000 0,26291265 0,28112464 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,26291265 0,280994 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,26291265 0,28086349 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,26950284 0,28776998 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,26950284 0,28763644 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,26950284 0,28750303 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,26950284 0,28736974 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,26950284 0,28723658 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,26950284 0,28710353 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,27603448 0,2939256 GO:0090047|positive regulation of transcription regulator activity, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,27603448 0,29378959 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,27603448 0,2936537 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,28250809 0,30040158 GO:0006956|complement activation, ! ion transmembrane transport GO:0034220 56 37 0,000 0,28250809 0,30026276 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,28250809 0,30012407 ! regulation of protein secretion GO:0050708 51 37 0,000 0,28250809 0,29998551 ! amino acid activation GO:0043038 52 37 0,000 0,28250809 0,29984708 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,28250809 0,29970877 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,28892419 0,30637419 ! gliogenesis GO:0042063 71 38 0,000 0,28892419 0,30623301 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,28892419 0,30609195 ! phagocytosis GO:0006909 60 38 0,000 0,28892419 0,30595102 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,29528327 0,31254096 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,29528327 0,3123972 ! chromatin remodeling GO:0006338 68 39 0,000 0,29528327 0,31225357 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,29528327 0,31211007 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,30158584 0,31862537 ! response to calcium ion GO:0051592 58 40 0,000 0,30158584 0,31847908 ! regulation of tube size GO:0035150 60 40 0,000 0,30158584 0,31833292 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,30158584 0,3181869 ! peptide metabolic process GO:0006518 56 40 0,000 0,30158584 0,31804101 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,30158584 0,31789525 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,30158584 0,31774963 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,30158584 0,31760414 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,30783241 0,32403411 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,30783241 0,32388588 ! striated muscle contraction GO:0006941 62 41 0,000 0,30783241 0,32373779 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,30783241 0,32358983 ! biopolymer methylation GO:0043414 62 41 0,000 0,30783241 0,323442 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,31402346 0,32979633 ! excretion GO:0007588 63 42 0,000 0,31402346 0,32964581 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,31402346 0,32949542 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,31402346 0,32934517 ! positive regulation of binding GO:0051099 59 43 0,000 0,32015949 0,33562754 ! neuromuscular process GO:0050905 79 43 0,000 0,32015949 0,33547464 ! tRNA processing GO:0008033 49 43 0,000 0,32015949 0,33532187 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,32015949 0,33516924 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,32624098 0,34138046 ! regulation of ion transport GO:0043269 57 44 0,000 0,32624098 0,34122522 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,32624098 0,34107012 ! RNA catabolic process GO:0006401 64 45 0,000 0,33226841 0,3472137 ! regulation of translational initiation GO:0006446 64 45 0,000 0,33226841 0,34705602 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,33226841 0,34689848 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,33226841 0,34674109 ! cell recognition GO:0008037 58 45 0,000 0,33226841 0,34658383 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,33824227 0,35265513 ! cell redox homeostasis GO:0045454 63 46 0,000 0,33824227 0,35249534 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,33824227 0,3523357 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,34416302 0,35834086 ! viral infectious cycle GO:0019058 71 47 0,000 0,34416302 0,35817871 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,34416302 0,35801671 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,34416302 0,35785486 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,35003114 0,36379196 ! gastrulation GO:0007369 73 48 0,000 0,35003114 0,36362765 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,35003114 0,36346348 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,35003114 0,36329946 ! regulation of endocytosis GO:0030100 63 48 0,000 0,35003114 0,36313559 ! nuclear export GO:0051168 69 48 0,000 0,35003114 0,36297187 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,35003114 0,3628083 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,35584708 0,3686704 ! sensory perception of smell GO:0007608 61 49 0,000 0,35584708 0,3685044 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,35584708 0,36833856 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,35584708 0,36817287 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,35584708 0,36800732 ! regulation of actin filament length GO:0030832 72 50 0,000 0,36161131 0,37380046 ! membrane fusion GO:0006944 80 50 0,000 0,36161131 0,37363253 ! proton transport GO:0015992 75 50 0,000 0,36161131 0,37346476 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,36161131 0,37329713 ! hydrogen transport GO:0006818 77 51 0,000 0,36732429 0,37902461 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,36732429 0,37885465 GO:0010863|positive regulation of phospholipase C activity, ! adult behavior GO:0030534 80 51 0,000 0,36732429 0,37868483 ! transition metal ion transport GO:0000041 74 52 0,000 0,37298647 0,38434985 ! regulation of cellular component size GO:0032535 74 52 0,000 0,37298647 0,38417773 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,37298647 0,38400576 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,37298647 0,38383395 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,37859829 0,38943474 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,37859829 0,38926065 ! single fertilization GO:0007338 59 53 0,000 0,37859829 0,38908671 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,38416021 0,39462639 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,38416021 0,39445021 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,38416021 0,3942742 ! exocytosis GO:0006887 74 55 0,000 0,38967266 0,3997534 ! mesoderm development GO:0007498 76 55 0,000 0,38967266 0,39957518 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,38967266 0,39939711 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,38967266 0,39921921 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,40055091 0,41018125 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,40055091 0,40999871 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,41123649 0,42074908 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,41650809 0,42595314 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,41650809 0,42576383 ! fertilization GO:0009566 68 60 0,000 0,41650809 0,42557468 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,42173279 0,43072177 ! extracellular matrix organization GO:0030198 103 61 0,000 0,42173279 0,43053059 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,42173279 0,43033958 ! amine catabolic process GO:0009310 90 62 0,000 0,42691101 0,43543029 ! neurotransmitter transport GO:0006836 81 62 0,000 0,42691101 0,43523729 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,42691101 0,43504445 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,42691101 0,43485178 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,42691101 0,43465928 ! regulation of lipase activity GO:0060191 109 63 0,000 0,43204315 0,43968993 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,43712962 0,44466967 ! adaptive immune response GO:0002250 94 64 0,000 0,43712962 0,44447309 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,44217083 0,44940031 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,44217083 0,44920181 ! defense response to bacterium GO:0042742 73 65 0,000 0,44217083 0,44900349 ! antigen processing and presentation GO:0019882 96 66 0,000 0,44716717 0,45387666 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,45211905 0,45870041 ! acute inflammatory response GO:0002526 92 68 0,000 0,45702686 0,46347521 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,45702686 0,46327094 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,46189098 0,46799527 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,46189098 0,46778919 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,47148971 0,47730033 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,47148971 0,47709034 ! regulation of blood pressure GO:0008217 107 73 0,000 0,4809183 0,48641693 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,4809183 0,48620312 ! digestion GO:0007586 97 74 0,000 0,48556973 0,49068998 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,49017975 0,49513106 ! tRNA metabolic process GO:0006399 95 76 0,000 0,49474871 0,49952679 ! response to unfolded protein GO:0006986 99 76 0,000 0,49474871 0,49930761 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,49927699 0,50365661 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,50376494 0,50796114 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,50821292 0,51222161 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,50821292 0,51199725 ! chromatin assembly GO:0031497 102 80 0,000 0,51262129 0,51621233 GO:0006334|nucleosome assembly, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,51262129 0,51598642 GO:0010498|proteasomal protein catabolic process, ! vitamin metabolic process GO:0006766 103 81 0,000 0,51699039 0,52015656 ! ossification GO:0001503 134 82 0,000 0,52132057 0,52428391 GO:0060348|bone development, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,52561218 0,52836889 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,52986555 0,53241187 ! sterol metabolic process GO:0016125 120 84 0,000 0,52986555 0,53217938 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,53408104 0,53617913 ! nucleosome organization GO:0034728 114 87 0,000 0,54239966 0,54429285 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,54239966 0,54405548 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,54239966 0,54381832 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,54650346 0,5476941 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,54650346 0,54745556 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,5505707 0,55128977 ! ATP metabolic process GO:0046034 137 91 0,000 0,55859675 0,55908291 ! electron transport chain GO:0022900 123 94 0,000 0,57036956 0,57061765 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,59298728 0,59298728