pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6565-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 10,000 2,032E-13 4,964E-10 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 5,000 4,755E-11 5,809E-08 ! cell cycle checkpoint GO:0000075 145 71 9,000 6,968E-11 5,674E-08 ! regulation of protein export from nucleus GO:0046825 10 7 4,000 3,231E-10 1,973E-07 ! organ growth GO:0035265 15 7 4,000 3,231E-10 1,579E-07 ! regulation of intracellular protein transport GO:0033157 86 42 7,000 4,673E-10 1,903E-07 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 7,000 1,009E-09 3,52E-07 ! regulation of protein localization GO:0032880 188 97 9,000 1,621E-09 4,95E-07 ! positive regulation of hormone secretion GO:0046887 35 19 5,000 2,666E-09 7,235E-07 ! DNA damage checkpoint GO:0000077 78 35 6,000 4,094E-09 1E-06 ! regulation of intracellular transport GO:0032386 108 57 7,000 5,98E-09 1,328E-06 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 4,000 6,949E-09 1,415E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! DNA integrity checkpoint GO:0031570 82 38 6,000 7,549E-09 1,419E-06 ! regulation of protein stability GO:0031647 77 38 6,000 7,549E-09 1,317E-06 ! regulation of cell-matrix adhesion GO:0001952 81 23 5,000 9,689E-09 1,578E-06 GO:0010810|regulation of cell-substrate adhesion, ! phospholipid dephosphorylation GO:0046839 12 5 3,000 1,132E-08 1,728E-06 ! DNA damage response, signal transduction GO:0042770 136 62 7,000 1,188E-08 1,707E-06 ! regulation of insulin secretion GO:0050796 42 25 5,000 1,68E-08 2,28E-06 ! glycolysis GO:0006096 71 46 6,000 3,054E-08 3,926E-06 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 3,377E-08 4,125E-06 ! regulation of peptide secretion GO:0002791 52 29 5,000 4,403E-08 5,122E-06 ! negative regulation of peptide secretion GO:0002792 10 7 3,000 7,836E-08 8,702E-06 GO:0046676|negative regulation of insulin secretion, ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 7,836E-08 8,324E-06 ! regulation of multicellular organism growth GO:0040014 90 55 6,000 1,098E-07 1,117E-05 ! glucose catabolic process GO:0006007 88 56 6,000 1,247E-07 1,219E-05 ! negative regulation of transport GO:0051051 164 85 7,000 1,473E-07 1,384E-05 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 1,559E-07 1,41E-05 ! regulation of growth hormone secretion GO:0060123 16 8 3,000 1,559E-07 1,36E-05 ! regulation of protein transport GO:0051223 165 87 7,000 1,768E-07 1,489E-05 GO:0070201|regulation of establishment of protein localization, ! apoptotic mitochondrial changes GO:0008637 42 20 4,000 2,216E-07 1,804E-05 ! positive regulation of secretion GO:0051047 110 61 6,000 2,278E-07 1,795E-05 ! gland development GO:0048732 220 91 7,000 2,51E-07 1,916E-05 ! regulation of cell adhesion GO:0030155 241 92 7,000 2,733E-07 2,023E-05 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 3,000 2,79E-07 2,005E-05 ! carbohydrate homeostasis GO:0033500 59 39 5,000 2,853E-07 1,992E-05 GO:0042593|glucose homeostasis, ! positive regulation of MAP kinase activity GO:0043406 174 93 7,000 2,972E-07 2,017E-05 ! regulation of hormone secretion GO:0046883 69 41 5,000 3,887E-07 2,566E-05 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 4,625E-07 2,974E-05 ! activation of pro-apoptotic gene products GO:0008633 51 23 4,000 4,727E-07 2,961E-05 ! hexose catabolic process GO:0019320 113 68 6,000 4,857E-07 2,966E-05 ! negative regulation of cell migration GO:0030336 122 46 5,000 7,865E-07 4,687E-05 ! focal adhesion formation GO:0048041 37 12 3,000 1,078E-06 6,272E-05 ! monosaccharide catabolic process GO:0046365 125 77 6,000 1,143E-06 6,491E-05 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 6,000 1,904E-06 1,057E-04 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of protein kinase cascade GO:0010741 72 30 4,000 1,924E-06 1,045E-04 ! cellular response to hormone stimulus GO:0032870 182 85 6,000 2,237E-06 1,188E-04 ! negative regulation of cell motion GO:0051271 142 55 5,000 2,31E-06 1,201E-04 ! alcohol catabolic process GO:0046164 142 87 6,000 2,617E-06 1,332E-04 ! triglyceride metabolic process GO:0006641 46 33 4,000 3,151E-06 1,571E-04 ! Notch receptor processing GO:0007220 11 5 2,000 3,281E-06 1,603E-04 ! substrate-bound cell migration, cell extension GO:0006930 6 5 2,000 3,281E-06 1,572E-04 ! positive regulation of protein modification process GO:0031401 156 90 6,000 3,288E-06 1,545E-04 ! regulation of cell cycle process GO:0010564 161 90 6,000 3,288E-06 1,516E-04 ! positive regulation of protein import into nucleus GO:0042307 34 16 3,000 3,879E-06 1,755E-04 ! negative regulation of hormone secretion GO:0046888 26 17 3,000 5,045E-06 2,241E-04 ! negative regulation of cell cycle process GO:0010948 35 17 3,000 5,045E-06 2,201E-04 ! endothelial cell migration GO:0043542 31 17 3,000 5,045E-06 2,162E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 3,000 5,045E-06 2,125E-04 ! cardiac muscle tissue development GO:0048738 34 17 3,000 5,045E-06 2,089E-04 ! neutrophil chemotaxis GO:0030593 29 17 3,000 5,045E-06 2,054E-04 ! negative regulation of cell adhesion GO:0007162 94 37 4,000 5,657E-06 2,265E-04 ! cell-substrate junction assembly GO:0007044 56 18 3,000 6,451E-06 2,542E-04 ! neutral lipid metabolic process GO:0006638 54 38 4,000 6,477E-06 2,512E-04 GO:0006639|acylglycerol metabolic process, ! myoblast cell fate commitment GO:0048625 18 6 2,000 6,529E-06 2,492E-04 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 2,000 6,529E-06 2,454E-04 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! activation of MAPK activity GO:0000187 124 67 5,000 7,419E-06 2,746E-04 ! chromosome segregation GO:0007059 127 67 5,000 7,419E-06 2,705E-04 ! inositol metabolic process GO:0006020 33 19 3,000 8,126E-06 2,92E-04 ! mammary gland development GO:0030879 93 40 4,000 8,395E-06 2,972E-04 ! glycerol ether metabolic process GO:0006662 57 40 4,000 8,395E-06 2,93E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 5,000 8,809E-06 3,031E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 5,000 8,809E-06 2,989E-04 ! negative regulation of kinase activity GO:0033673 145 70 5,000 9,579E-06 3,206E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 3,000 1,01E-05 3,335E-04 ! organic ether metabolic process GO:0018904 59 42 4,000 1,073E-05 3,495E-04 ! amyloid precursor protein catabolic process GO:0042987 15 7 2,000 1,137E-05 3,654E-04 ! spindle checkpoint GO:0031577 16 7 2,000 1,137E-05 3,606E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 1,137E-05 3,56E-04 ! negative regulation of nuclear division GO:0051784 15 7 2,000 1,137E-05 3,515E-04 GO:0045839|negative regulation of mitosis, ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 5,000 1,322E-05 4,038E-04 ! negative regulation of transferase activity GO:0051348 155 74 5,000 1,322E-05 3,989E-04 ! inactivation of MAPK activity GO:0000188 45 22 3,000 1,509E-05 4,495E-04 ! apoptotic nuclear changes GO:0030262 34 22 3,000 1,509E-05 4,441E-04 ! cell aging GO:0007569 48 22 3,000 1,509E-05 4,388E-04 ! positive regulation of intracellular transport GO:0032388 42 22 3,000 1,509E-05 4,336E-04 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 3,000 1,509E-05 4,286E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 1,515E-05 4,255E-04 ! developmental growth GO:0048589 88 45 4,000 1,515E-05 4,207E-04 ! positive regulation of insulin secretion GO:0032024 17 8 2,000 1,809E-05 4,967E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,809E-05 4,911E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 2,168E-05 5,82E-04 ! positive regulation of phosphorylation GO:0042327 149 81 5,000 2,225E-05 5,908E-04 ! JNK cascade GO:0007254 106 49 4,000 2,312E-05 6,074E-04 ! regulation of peptidase activity GO:0052547 150 82 5,000 2,387E-05 6,203E-04 ! activation of caspase activity GO:0006919 95 50 4,000 2,554E-05 6,569E-04 ! protein import into nucleus, translocation GO:0000060 51 25 3,000 2,567E-05 6,532E-04 ! induction of positive chemotaxis GO:0050930 17 9 2,000 2,7E-05 6,8E-04 ! amyloid precursor protein metabolic process GO:0042982 18 9 2,000 2,7E-05 6,731E-04 ! T cell selection GO:0045058 27 9 2,000 2,7E-05 6,663E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 2,7E-05 6,596E-04 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 4,000 2,816E-05 6,812E-04 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 3,017E-05 7,226E-04 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of muscle contraction GO:0006937 94 54 4,000 3,728E-05 8,841E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 3,837E-05 9,014E-04 ! alpha-beta T cell differentiation GO:0046632 24 10 2,000 3,837E-05 8,928E-04 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 3,837E-05 8,844E-04 ! response to UV GO:0009411 120 55 4,000 4,077E-05 9,309E-04 ! positive regulation of caspase activity GO:0043280 108 57 4,000 4,852E-05 1,098E-03 GO:0010952|positive regulation of peptidase activity, ! substrate-bound cell migration GO:0006929 14 11 2,000 5,249E-05 1,177E-03 ! chondrocyte differentiation GO:0002062 27 11 2,000 5,249E-05 1,166E-03 ! positive regulation of peptide secretion GO:0002793 24 11 2,000 5,249E-05 1,155E-03 ! alpha-beta T cell activation GO:0046631 26 11 2,000 5,249E-05 1,145E-03 ! oocyte development GO:0048599 20 11 2,000 5,249E-05 1,135E-03 ! negative regulation of glucose import GO:0046325 18 11 2,000 5,249E-05 1,125E-03 GO:0010829|negative regulation of glucose transport, ! aging GO:0007568 112 58 4,000 5,28E-05 1,122E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 3,000 5,411E-05 1,14E-03 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 6,176E-05 1,29E-03 ! cell junction assembly GO:0034329 85 31 3,000 6,178E-05 1,279E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 5,000 6,541E-05 1,343E-03 ! regulation of positive chemotaxis GO:0050926 22 12 2,000 6,963E-05 1,418E-03 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 2,000 6,963E-05 1,406E-03 ! regulation of hormone metabolic process GO:0032350 28 12 2,000 6,963E-05 1,394E-03 ! T cell homeostasis GO:0043029 28 12 2,000 6,963E-05 1,383E-03 ! oocyte differentiation GO:0009994 21 12 2,000 6,963E-05 1,372E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 6,963E-05 1,361E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of protein import into nucleus GO:0042306 69 32 3,000 7,023E-05 1,362E-03 ! regulation of mitosis GO:0007088 112 63 4,000 7,874E-05 1,515E-03 GO:0051783|regulation of nuclear division, ! leukocyte chemotaxis GO:0030595 55 33 3,000 7,948E-05 1,517E-03 GO:0060326|cell chemotaxis, ! negative regulation of MAP kinase activity GO:0043407 78 34 3,000 8,959E-05 1,697E-03 ! membrane protein proteolysis GO:0033619 33 13 2,000 9,006E-05 1,692E-03 GO:0006509|membrane protein ectodomain proteolysis, ! gland morphogenesis GO:0022612 31 13 2,000 9,006E-05 1,679E-03 ! digestive tract morphogenesis GO:0048546 31 13 2,000 9,006E-05 1,667E-03 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mitotic cell cycle GO:0045930 35 13 2,000 9,006E-05 1,654E-03 ! multicellular organism reproduction GO:0032504 123 65 4,000 9,15E-05 1,668E-03 GO:0048609|reproductive process in a multicellular organism, ! negative regulation of secretion GO:0051048 68 35 3,000 1,006E-04 1,82E-03 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 2,000 1,14E-04 2,048E-03 GO:0046579|positive regulation of Ras protein signal transduction, ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 1,14E-04 2,033E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 2,000 1,14E-04 2,019E-03 GO:0060675|ureteric bud morphogenesis, ! response to gamma radiation GO:0010332 30 14 2,000 1,14E-04 2,004E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 1,14E-04 1,99E-03 ! negative regulation of cell size GO:0045792 144 69 4,000 1,217E-04 2,109E-03 ! developmental maturation GO:0021700 128 69 4,000 1,217E-04 2,094E-03 ! cell junction organization GO:0034330 96 37 3,000 1,255E-04 2,144E-03 ! androgen receptor signaling pathway GO:0030521 81 37 3,000 1,255E-04 2,129E-03 ! germ cell development GO:0007281 133 70 4,000 1,303E-04 2,196E-03 ! meiosis I GO:0007127 74 38 3,000 1,395E-04 2,335E-03 ! glycoprotein catabolic process GO:0006516 33 15 2,000 1,418E-04 2,357E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 1,418E-04 2,341E-03 ! lymphocyte homeostasis GO:0002260 33 15 2,000 1,418E-04 2,325E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 1,418E-04 2,31E-03 ! regulation of caspase activity GO:0043281 136 74 4,000 1,696E-04 2,744E-03 ! nucleus organization GO:0006997 73 40 3,000 1,709E-04 2,746E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,736E-04 2,772E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! mesenchymal cell development GO:0014031 94 41 3,000 1,883E-04 2,987E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! cell-matrix adhesion GO:0007160 181 76 4,000 1,923E-04 3,032E-03 ! regulation of endopeptidase activity GO:0052548 141 77 4,000 2,045E-04 3,203E-03 ! regulation of T cell differentiation GO:0045580 78 42 3,000 2,07E-04 3,221E-03 ! myoblast differentiation GO:0045445 50 17 2,000 2,098E-04 3,243E-03 ! regulation of survival gene product expression GO:0045884 38 17 2,000 2,098E-04 3,223E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 2,098E-04 3,203E-03 ! branched chain family amino acid metabolic process GO:0009081 37 17 2,000 2,098E-04 3,183E-03 ! hormone-mediated signaling GO:0009755 84 43 3,000 2,27E-04 3,423E-03 ! regulation of T cell proliferation GO:0042129 80 43 3,000 2,27E-04 3,402E-03 ! negative regulation of organelle organization GO:0010639 181 80 4,000 2,447E-04 3,645E-03 ! regulation of viral genome replication GO:0045069 30 18 2,000 2,504E-04 3,708E-03 ! meiosis GO:0007126 143 81 4,000 2,593E-04 3,817E-03 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 4,000 2,593E-04 3,794E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 2,711E-04 3,942E-03 ! polyol metabolic process GO:0019751 77 45 3,000 2,711E-04 3,919E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 2,746E-04 3,947E-03 ! protein import into nucleus GO:0006606 174 82 4,000 2,746E-04 3,924E-03 ! meiotic cell cycle GO:0051321 144 82 4,000 2,746E-04 3,901E-03 ! response to oxygen levels GO:0070482 183 83 4,000 2,906E-04 4,104E-03 ! nuclear import GO:0051170 177 83 4,000 2,906E-04 4,08E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 3,000 2,953E-04 4,122E-03 ! leukocyte migration GO:0050900 75 46 3,000 2,953E-04 4,099E-03 ! pigmentation GO:0043473 103 46 3,000 2,953E-04 4,076E-03 ! positive regulation of protein transport GO:0051222 80 46 3,000 2,953E-04 4,053E-03 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 2,000 2,959E-04 4,038E-03 ! proximal/distal pattern formation GO:0009954 33 19 2,000 2,959E-04 4,015E-03 ! response to alkaloid GO:0043279 38 20 2,000 3,463E-04 4,674E-03 ! pancreas development GO:0031016 40 20 2,000 3,463E-04 4,648E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 3,463E-04 4,623E-03 ! regulation of glucose import GO:0046324 30 20 2,000 3,463E-04 4,598E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 3,463E-04 4,573E-03 ! positive regulation of cell cycle GO:0045787 96 48 3,000 3,483E-04 4,575E-03 ! regulation of JAK-STAT cascade GO:0046425 76 48 3,000 3,483E-04 4,55E-03 ! cellular component disassembly GO:0022411 89 48 3,000 3,483E-04 4,526E-03 ! mitochondrion organization GO:0007005 159 87 4,000 3,616E-04 4,674E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 3,772E-04 4,85E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 3,772E-04 4,825E-03 ! protein localization in nucleus GO:0034504 192 89 4,000 4,017E-04 5,111E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 4,019E-04 5,088E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 4,019E-04 5,061E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 4,019E-04 5,035E-03 ! regulation of ARF protein signal transduction GO:0032012 115 50 3,000 4,078E-04 5,083E-03 ! positive regulation of protein catabolic process GO:0045732 44 22 2,000 4,63E-04 5,742E-03 ! reciprocal meiotic recombination GO:0007131 44 22 2,000 4,63E-04 5,713E-03 ! ureteric bud development GO:0001657 50 22 2,000 4,63E-04 5,684E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 4,63E-04 5,656E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! peptidyl-serine modification GO:0018209 50 22 2,000 4,63E-04 5,627E-03 ! gut development GO:0048565 44 22 2,000 4,63E-04 5,6E-03 ! Notch signaling pathway GO:0007219 111 52 3,000 4,742E-04 5,707E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 4,744E-04 5,681E-03 GO:0045844|positive regulation of striated muscle development, ! neuron fate determination GO:0048664 7 5 1,000 4,744E-04 5,653E-03 ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 4,744E-04 5,626E-03 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 1,000 4,744E-04 5,598E-03 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 4,744E-04 5,572E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 4,744E-04 5,545E-03 ! anagen GO:0042640 7 5 1,000 4,744E-04 5,518E-03 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 4,744E-04 5,492E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 4,744E-04 5,466E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 4,744E-04 5,441E-03 ! valine metabolic process GO:0006573 12 5 1,000 4,744E-04 5,415E-03 ! response to food GO:0032094 6 5 1,000 4,744E-04 5,39E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 1,000 4,744E-04 5,365E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 4,744E-04 5,34E-03 ! positive regulation of vasoconstriction GO:0045907 10 5 1,000 4,744E-04 5,316E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 4,744E-04 5,292E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 4,744E-04 5,268E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 4,744E-04 5,244E-03 ! regulation of leukocyte degranulation GO:0043300 8 5 1,000 4,744E-04 5,22E-03 ! positive regulation of mast cell activation GO:0033005 12 5 1,000 4,744E-04 5,197E-03 ! B cell homeostasis GO:0001782 13 5 1,000 4,744E-04 5,174E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 4,744E-04 5,151E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 4,744E-04 5,128E-03 ! somatic stem cell maintenance GO:0035019 15 5 1,000 4,744E-04 5,105E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 4,744E-04 5,083E-03 ! negative regulation of actin filament bundle formation GO:0032232 17 5 1,000 4,744E-04 5,061E-03 GO:0051497|negative regulation of stress fiber formation, ! stem cell division GO:0017145 11 5 1,000 4,744E-04 5,039E-03 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 1,000 4,744E-04 5,017E-03 ! positive regulation of growth GO:0045927 96 53 3,000 5,101E-04 5,372E-03 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 3,000 5,101E-04 5,349E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 5,101E-04 5,326E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of membrane potential GO:0042391 179 94 4,000 5,165E-04 5,369E-03 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 2,000 5,297E-04 5,484E-03 ! regulation of chemotaxis GO:0050920 45 23 2,000 5,297E-04 5,46E-03 ! epithelial tube morphogenesis GO:0060562 114 54 3,000 5,479E-04 5,625E-03 ! cell maturation GO:0048469 107 55 3,000 5,877E-04 6,008E-03 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 2,000 6,023E-04 6,131E-03 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 6,023E-04 6,106E-03 ! regulation of viral reproduction GO:0050792 41 24 2,000 6,023E-04 6,08E-03 ! oogenesis GO:0048477 44 24 2,000 6,023E-04 6,055E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 6,023E-04 6,03E-03 ! skeletal muscle fiber development GO:0048741 130 56 3,000 6,295E-04 6,277E-03 ! regulation of protein catabolic process GO:0042176 126 56 3,000 6,295E-04 6,252E-03 ! regulation of DNA replication GO:0006275 105 56 3,000 6,295E-04 6,226E-03 ! muscle fiber development GO:0048747 131 57 3,000 6,734E-04 6,633E-03 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 6,809E-04 6,681E-03 ! vasculogenesis GO:0001570 49 25 2,000 6,809E-04 6,654E-03 ! negative regulation of DNA replication GO:0008156 45 25 2,000 6,809E-04 6,628E-03 ! regulation of behavior GO:0050795 48 25 2,000 6,809E-04 6,601E-03 ! leukocyte homeostasis GO:0001776 50 25 2,000 6,809E-04 6,575E-03 ! skeletal muscle tissue development GO:0007519 223 100 4,000 6,849E-04 6,588E-03 GO:0060538|skeletal muscle organ development, ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 1,000 7,083E-04 6,786E-03 GO:0046580|negative regulation of Ras protein signal transduction, ! forebrain regionalization GO:0021871 9 6 1,000 7,083E-04 6,759E-03 ! erythrocyte maturation GO:0043249 8 6 1,000 7,083E-04 6,733E-03 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 1,000 7,083E-04 6,707E-03 ! regulation of retroviral genome replication GO:0045091 8 6 1,000 7,083E-04 6,681E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 7,083E-04 6,655E-03 ! positive regulation of exocytosis GO:0045921 11 6 1,000 7,083E-04 6,63E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 7,083E-04 6,604E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 7,083E-04 6,579E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of spindle localization GO:0051293 16 6 1,000 7,083E-04 6,554E-03 GO:0051653|spindle localization, ! neural nucleus development GO:0048857 19 6 1,000 7,083E-04 6,53E-03 ! response to UV-C GO:0010225 14 6 1,000 7,083E-04 6,505E-03 ! positive regulation of B cell differentiation GO:0045579 13 6 1,000 7,083E-04 6,481E-03 ! hair follicle maturation GO:0048820 8 6 1,000 7,083E-04 6,456E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 7,083E-04 6,432E-03 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 1,000 7,083E-04 6,409E-03 ! regulation of mast cell activation GO:0033003 13 6 1,000 7,083E-04 6,385E-03 ! positive regulation of pseudopodium assembly GO:0031274 15 6 1,000 7,083E-04 6,362E-03 GO:0031272|regulation of pseudopodium assembly, ! ectodermal gut morphogenesis GO:0048567 16 6 1,000 7,083E-04 6,338E-03 GO:0007439|ectodermal gut development, ! negative regulation of B cell activation GO:0050869 14 6 1,000 7,083E-04 6,315E-03 ! molting cycle process GO:0022404 52 26 2,000 7,658E-04 6,803E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 7,658E-04 6,779E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 7,658E-04 6,754E-03 ! lipid modification GO:0030258 112 60 3,000 8,178E-04 7,187E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 8,572E-04 7,505E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 8,572E-04 7,479E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 8,572E-04 7,452E-03 ! regulation of heart contraction GO:0008016 123 61 3,000 8,705E-04 7,541E-03 ! neuron fate commitment GO:0048663 52 28 2,000 9,551E-04 8,245E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 9,551E-04 8,216E-03 ! fat cell differentiation GO:0045444 57 28 2,000 9,551E-04 8,187E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 9,551E-04 8,158E-03 ! prostate gland development GO:0030850 14 7 1,000 9,871E-04 8,402E-03 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 1,000 9,871E-04 8,373E-03 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 9,871E-04 8,344E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 9,871E-04 8,315E-03 ! spinal cord patterning GO:0021511 14 7 1,000 9,871E-04 8,286E-03 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 9,871E-04 8,258E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 9,871E-04 8,23E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 9,871E-04 8,202E-03 ! peptidyl-threonine modification GO:0018210 26 7 1,000 9,871E-04 8,174E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 9,871E-04 8,147E-03 ! positive regulation of microtubule polymerization GO:0031116 15 7 1,000 9,871E-04 8,119E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 9,871E-04 8,092E-03 ! SMAD protein complex assembly GO:0007183 13 7 1,000 9,871E-04 8,065E-03 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 9,871E-04 8,038E-03 ! centrosome duplication GO:0051298 14 7 1,000 9,871E-04 8,011E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 9,871E-04 7,985E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 1,043E-03 8,408E-03 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 1,043E-03 8,38E-03 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 1,06E-03 8,489E-03 ! response to organic cyclic substance GO:0014070 58 29 2,000 1,06E-03 8,462E-03 ! negative regulation of neuron apoptosis GO:0043524 69 29 2,000 1,06E-03 8,434E-03 ! ear development GO:0043583 114 66 3,000 1,17E-03 9,281E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 1,17E-03 9,251E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 1,172E-03 9,233E-03 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 2,000 1,172E-03 9,203E-03 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 2,000 1,172E-03 9,174E-03 ! negative regulation of cell growth GO:0030308 142 67 3,000 1,238E-03 9,66E-03 ! iron ion homeostasis GO:0055072 60 31 2,000 1,291E-03 0,01004065 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 1,291E-03 0,01000878 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 1,291E-03 9,977E-03 ! response to heat GO:0009408 54 31 2,000 1,291E-03 9,946E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,31E-03 0,01006423 ! male meiosis GO:0007140 9 8 1,000 1,31E-03 0,01003268 ! succinate metabolic process GO:0006105 17 8 1,000 1,31E-03 0,01000132 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,31E-03 9,97E-03 ! hemoglobin metabolic process GO:0020027 14 8 1,000 1,31E-03 9,939E-03 ! pigment granule organization GO:0048753 17 8 1,000 1,31E-03 9,908E-03 ! regulation of pigmentation during development GO:0048070 25 8 1,000 1,31E-03 9,878E-03 ! melanin metabolic process GO:0006582 17 8 1,000 1,31E-03 9,847E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,31E-03 9,817E-03 ! response to UV-B GO:0010224 17 8 1,000 1,31E-03 9,787E-03 ! DNA topological change GO:0006265 12 8 1,000 1,31E-03 9,757E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 1,31E-03 9,728E-03 ! gas homeostasis GO:0033483 14 8 1,000 1,31E-03 9,698E-03 ! regulation of Rac protein signal transduction GO:0035020 18 8 1,000 1,31E-03 9,669E-03 ! blastocyst growth GO:0001832 19 8 1,000 1,31E-03 9,64E-03 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 1,000 1,31E-03 9,611E-03 ! B cell receptor signaling pathway GO:0050853 22 8 1,000 1,31E-03 9,582E-03 ! negative regulation of DNA replication initiation GO:0032297 10 8 1,000 1,31E-03 9,554E-03 GO:0000076|DNA replication checkpoint, ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 1,000 1,31E-03 9,525E-03 ! regulation of microtubule polymerization GO:0031113 17 8 1,000 1,31E-03 9,497E-03 ! urogenital system development GO:0001655 149 69 3,000 1,381E-03 9,981E-03 ! homeostasis of number of cells GO:0048872 131 69 3,000 1,381E-03 9,952E-03 ! spindle organization GO:0007051 50 32 2,000 1,417E-03 0,0101799 ! metanephros development GO:0001656 81 32 2,000 1,417E-03 0,01015005 ! hindbrain development GO:0030902 65 32 2,000 1,417E-03 0,01012037 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,417E-03 0,01009086 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,535E-03 0,01090402 ! response to ionizing radiation GO:0010212 74 33 2,000 1,55E-03 0,01097932 ! negative regulation of protein transport GO:0051224 74 33 2,000 1,55E-03 0,01094759 ! actin filament organization GO:0007015 167 72 3,000 1,617E-03 0,01138392 ! regulation of epithelial cell differentiation GO:0030856 18 9 1,000 1,677E-03 0,01177007 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,677E-03 0,01173634 ! receptor clustering GO:0043113 20 9 1,000 1,677E-03 0,01170281 ! regulation of Notch signaling pathway GO:0008593 24 9 1,000 1,677E-03 0,01166947 ! erythrocyte development GO:0048821 17 9 1,000 1,677E-03 0,01163632 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,677E-03 0,01160336 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,677E-03 0,01157058 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 1,692E-03 0,01164297 ! negative regulation of DNA metabolic process GO:0051053 65 35 2,000 1,841E-03 0,012634 ! reproductive structure development GO:0048608 131 75 3,000 1,88E-03 0,01286246 ! axon guidance GO:0007411 162 75 3,000 1,88E-03 0,01282653 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 2,000 1,998E-03 0,01359774 ! negative regulation of DNA binding GO:0043392 67 36 2,000 1,998E-03 0,01355997 ! phosphoinositide metabolic process GO:0030384 146 77 3,000 2,07E-03 0,01401018 ! regulation of catabolic process GO:0009894 173 77 3,000 2,07E-03 0,01397148 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 1,000 2,086E-03 0,01404006 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 2,086E-03 0,01400149 ! smoothened signaling pathway GO:0007224 18 10 1,000 2,086E-03 0,01396313 ! pathogenesis GO:0009405 17 10 1,000 2,086E-03 0,01392498 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 2,086E-03 0,01388704 ! glucan biosynthetic process GO:0009250 14 10 1,000 2,086E-03 0,0138493 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 1,000 2,086E-03 0,01381177 GO:0006600|creatine metabolic process, ! regulation of stress fiber formation GO:0051492 34 10 1,000 2,086E-03 0,01377444 ! B cell proliferation GO:0042100 19 10 1,000 2,086E-03 0,01373731 ! multicellular organism growth GO:0035264 19 10 1,000 2,086E-03 0,01370039 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 2,086E-03 0,01366366 ! motor axon guidance GO:0008045 22 10 1,000 2,086E-03 0,01362712 ! DNA ligation GO:0006266 18 10 1,000 2,086E-03 0,01359078 ! regulation of B cell differentiation GO:0045577 24 10 1,000 2,086E-03 0,01355464 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 2,086E-03 0,01351868 ! hindbrain morphogenesis GO:0021575 19 10 1,000 2,086E-03 0,01348292 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,086E-03 0,01344734 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 2,086E-03 0,01341196 ! positive regulation of viral reproduction GO:0048524 19 10 1,000 2,086E-03 0,01337675 ! response to nicotine GO:0035094 20 10 1,000 2,086E-03 0,01334174 ! regulation of microtubule-based process GO:0032886 86 37 2,000 2,163E-03 0,01379964 ! negative regulation of cell activation GO:0050866 69 37 2,000 2,163E-03 0,01376371 ! female gonad development GO:0008585 71 37 2,000 2,163E-03 0,01372796 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 2,000 2,337E-03 0,01479034 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 2,337E-03 0,01475212 ! muscle cell differentiation GO:0042692 178 81 3,000 2,491E-03 0,01568356 ! negative regulation of binding GO:0051100 71 39 2,000 2,519E-03 0,01581838 ! mitotic cell cycle checkpoint GO:0007093 76 39 2,000 2,519E-03 0,01577782 ! neuron fate specification GO:0048665 18 11 1,000 2,538E-03 0,01585834 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,538E-03 0,01581788 ! N-glycan processing GO:0006491 24 11 1,000 2,538E-03 0,01577764 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,538E-03 0,01573759 ! behavioral fear response GO:0001662 27 11 1,000 2,538E-03 0,01569775 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 2,538E-03 0,01565811 ! thymus development GO:0048538 29 11 1,000 2,538E-03 0,01561867 ! embryonic gut development GO:0048566 19 11 1,000 2,538E-03 0,01557942 ! regulation of actin filament bundle formation GO:0032231 37 11 1,000 2,538E-03 0,01554038 ! sequestering of metal ion GO:0051238 15 11 1,000 2,538E-03 0,01550153 ! development of primary female sexual characteristics GO:0046545 80 40 2,000 2,709E-03 0,0165048 GO:0046660|female sex differentiation, ! response to drug GO:0042493 149 83 3,000 2,722E-03 0,01654006 ! negative regulation of growth GO:0045926 168 85 3,000 2,967E-03 0,01798456 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 3,032E-03 0,01833344 ! virus-host interaction GO:0019048 30 12 1,000 3,032E-03 0,01828817 ! regulation of B cell proliferation GO:0030888 22 12 1,000 3,032E-03 0,01824313 ! protein complex disassembly GO:0043241 28 12 1,000 3,032E-03 0,01819831 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 3,032E-03 0,0181537 ! regulation of cell projection assembly GO:0060491 33 12 1,000 3,032E-03 0,01810932 ! ventral spinal cord development GO:0021517 25 12 1,000 3,032E-03 0,01806515 ! mitotic spindle organization GO:0007052 23 12 1,000 3,032E-03 0,01802119 ! cranial nerve development GO:0021545 23 12 1,000 3,032E-03 0,01797745 ! histone acetylation GO:0016573 27 12 1,000 3,032E-03 0,01793392 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 2,000 3,116E-03 0,018387 ! T cell differentiation GO:0030217 93 42 2,000 3,116E-03 0,0183427 ! dorsal/ventral pattern formation GO:0009953 75 42 2,000 3,116E-03 0,01829861 ! cytokinesis GO:0000910 84 42 2,000 3,116E-03 0,01825472 ! glucose transport GO:0015758 66 43 2,000 3,333E-03 0,01947738 ! tube morphogenesis GO:0035239 194 89 3,000 3,501E-03 0,02041431 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 3,558E-03 0,02069732 ! hexose transport GO:0008645 68 44 2,000 3,558E-03 0,02064816 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 2,000 3,558E-03 0,02059923 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 3,567E-03 0,02059902 GO:0000725|recombinational repair, ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 3,567E-03 0,02055043 ! plasma membrane organization GO:0007009 27 13 1,000 3,567E-03 0,02050208 ! response to X-ray GO:0010165 28 13 1,000 3,567E-03 0,02045395 ! monoamine transport GO:0015844 21 13 1,000 3,567E-03 0,02040605 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,567E-03 0,02035837 ! spleen development GO:0048536 24 13 1,000 3,567E-03 0,02031092 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 1,000 3,567E-03 0,02026368 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 3,567E-03 0,02021667 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 3,793E-03 0,02145021 ! female gamete generation GO:0007292 71 45 2,000 3,793E-03 0,02140067 ! maintenance of location in cell GO:0051651 101 45 2,000 3,793E-03 0,02135136 ! regulation of S phase GO:0033261 26 14 1,000 4,142E-03 0,0232625 ! hair follicle morphogenesis GO:0031069 27 14 1,000 4,142E-03 0,02320914 ! lipid localization GO:0010876 32 14 1,000 4,142E-03 0,02315603 GO:0019915|lipid storage, ! fear response GO:0042596 34 14 1,000 4,142E-03 0,02310316 ! embryo implantation GO:0007566 30 14 1,000 4,142E-03 0,02305054 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 4,142E-03 0,02299815 ! regulation of calcium-mediated signaling GO:0050848 29 14 1,000 4,142E-03 0,022946 ! positive regulation of protein polymerization GO:0032273 27 14 1,000 4,142E-03 0,02289409 ! neural tube development GO:0021915 91 47 2,000 4,29E-03 0,02366059 ! response to insulin stimulus GO:0032868 98 47 2,000 4,29E-03 0,0236073 ! positive regulation of defense response GO:0031349 88 48 2,000 4,553E-03 0,02499706 ! regulation of inflammatory response GO:0050727 84 48 2,000 4,553E-03 0,02494101 ! sex differentiation GO:0007548 171 96 3,000 4,588E-03 0,02507287 ! regulation of T cell activation GO:0050863 175 96 3,000 4,588E-03 0,0250169 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 4,758E-03 0,02588572 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 4,758E-03 0,02582819 ! regulation of mRNA processing GO:0050684 26 15 1,000 4,758E-03 0,02577092 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 4,758E-03 0,02571391 ! regulation of exocytosis GO:0017157 26 15 1,000 4,758E-03 0,02565714 ! regulation of vasodilation GO:0042312 27 15 1,000 4,758E-03 0,02560063 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 4,758E-03 0,02554437 ! forebrain development GO:0030900 210 98 3,000 4,935E-03 0,02644032 ! regulation of action potential GO:0001508 102 50 2,000 5,108E-03 0,02730405 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 5,108E-03 0,02724444 ! hormone metabolic process GO:0042445 171 100 3,000 5,3E-03 0,02820943 ! response to temperature stimulus GO:0009266 84 51 2,000 5,399E-03 0,02867528 ! negative regulation of immune system process GO:0002683 101 51 2,000 5,399E-03 0,02861307 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 5,412E-03 0,02862007 ! pituitary gland development GO:0021983 30 16 1,000 5,412E-03 0,02855825 ! stem cell development GO:0048864 46 16 1,000 5,412E-03 0,02849671 GO:0019827|stem cell maintenance, ! regulation of dephosphorylation GO:0035303 43 16 1,000 5,412E-03 0,02843542 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 1,000 5,412E-03 0,0283744 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 5,412E-03 0,02831364 ! response to estrogen stimulus GO:0043627 98 52 2,000 5,701E-03 0,02975917 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 5,701E-03 0,02969572 ! vesicle organization GO:0016050 127 53 2,000 6,012E-03 0,03125139 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 6,012E-03 0,03118504 ! cartilage development GO:0051216 99 53 2,000 6,012E-03 0,03111897 ! metencephalon development GO:0022037 32 17 1,000 6,106E-03 0,0315373 ! signal complex assembly GO:0007172 47 17 1,000 6,106E-03 0,03147076 ! auditory receptor cell differentiation GO:0042491 36 17 1,000 6,106E-03 0,03140451 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 1,000 6,106E-03 0,03133853 ! regulation of striated muscle contraction GO:0006942 23 17 1,000 6,106E-03 0,03127283 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 6,106E-03 0,03120741 GO:0031114|regulation of microtubule depolymerization, ! regulation of protein binding GO:0043393 33 17 1,000 6,106E-03 0,03114226 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 6,106E-03 0,03107738 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 6,106E-03 0,03101277 ! positive regulation of protein complex assembly GO:0031334 34 18 1,000 6,838E-03 0,03465832 ! centrosome cycle GO:0007098 26 18 1,000 6,838E-03 0,03458657 ! positive regulation of proteolysis GO:0045862 36 18 1,000 6,838E-03 0,03451511 ! epidermis morphogenesis GO:0048730 43 18 1,000 6,838E-03 0,03444394 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 6,838E-03 0,03437307 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 6,838E-03 0,03430249 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 1,000 6,838E-03 0,0342322 ! nerve development GO:0021675 34 18 1,000 6,838E-03 0,03416219 ! defense response to virus GO:0051607 43 18 1,000 6,838E-03 0,03409247 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 6,838E-03 0,03402304 ! negative regulation of cytoskeleton organization GO:0051494 139 56 2,000 7,007E-03 0,03479253 ! regulation of neuronal synaptic plasticity GO:0048168 51 19 1,000 7,608E-03 0,03769901 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 7,608E-03 0,0376227 ! pigmentation during development GO:0048066 42 19 1,000 7,608E-03 0,03754669 ! neuromuscular junction development GO:0007528 43 19 1,000 7,608E-03 0,03747099 ! visual learning GO:0008542 38 19 1,000 7,608E-03 0,0373956 ! cellular pigmentation GO:0033059 37 19 1,000 7,608E-03 0,0373205 ! embryonic organ morphogenesis GO:0048562 34 19 1,000 7,608E-03 0,03724571 ! positive regulation of cell migration GO:0030335 137 58 2,000 7,721E-03 0,03772454 ! positive regulation of organelle organization GO:0010638 108 58 2,000 7,721E-03 0,03764924 ! maintenance of location GO:0051235 124 58 2,000 7,721E-03 0,03757424 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 8,415E-03 0,04086816 ! protein amino acid acetylation GO:0006473 41 20 1,000 8,415E-03 0,04078707 ! actin filament bundle formation GO:0051017 47 20 1,000 8,415E-03 0,0407063 ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 8,415E-03 0,04062586 ! DNA catabolic process GO:0006308 94 60 2,000 8,476E-03 0,04084378 ! kidney development GO:0001822 133 60 2,000 8,476E-03 0,04076338 ! cytokine-mediated signaling pathway GO:0019221 112 61 2,000 8,87E-03 0,04257149 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 8,87E-03 0,04248802 ! ovarian follicle development GO:0001541 39 21 1,000 9,258E-03 0,04426064 ! cellular macromolecular complex disassembly GO:0034623 44 21 1,000 9,258E-03 0,04417419 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 9,258E-03 0,04408808 ! regulation of vasoconstriction GO:0019229 40 21 1,000 9,258E-03 0,04400231 ! diencephalon development GO:0021536 36 21 1,000 9,258E-03 0,04391687 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 9,258E-03 0,04383176 ! leukotriene biosynthetic process GO:0019370 42 21 1,000 9,258E-03 0,04374698 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 1,000 9,258E-03 0,04366252 ! regulation of homeostatic process GO:0032844 148 62 2,000 9,274E-03 0,04365266 ! skeletal system morphogenesis GO:0048705 118 63 2,000 9,688E-03 0,04551625 ! integrin-mediated signaling pathway GO:0007229 160 64 2,000 0,01011346 0,04742262 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 0,01013745 0,04744405 ! stem cell differentiation GO:0048863 57 22 1,000 0,01013745 0,04735333 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 0,01013745 0,04726297 ! renal system process GO:0003014 42 22 1,000 0,01013745 0,04717294 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 0,01013745 0,04708326 ! positive regulation of B cell activation GO:0050871 42 22 1,000 0,01013745 0,04699392 ! response to cytokine stimulus GO:0034097 69 22 1,000 0,01013745 0,04690491 ! activation of JUN kinase activity GO:0007257 47 22 1,000 0,01013745 0,04681625 ! inner ear receptor cell differentiation GO:0060113 42 22 1,000 0,01013745 0,04672791 ! protein stabilization GO:0050821 41 22 1,000 0,01013745 0,04663991 ! positive regulation of cell motion GO:0051272 157 65 2,000 0,01054935 0,04844371 ! gonad development GO:0008406 115 66 2,000 0,01099598 0,05039994 ! positive regulation of DNA replication GO:0045740 44 23 1,000 0,01105247 0,05056403 ! gluconeogenesis GO:0006094 38 23 1,000 0,01105247 0,05046952 ! regeneration GO:0031099 42 23 1,000 0,01105247 0,05037536 ! axis specification GO:0009798 43 23 1,000 0,01105247 0,05028155 ! visual behavior GO:0007632 46 23 1,000 0,01105247 0,05018809 ! regulation of DNA recombination GO:0000018 51 23 1,000 0,01105247 0,05009497 ! response to ethanol GO:0045471 47 23 1,000 0,01105247 0,0500022 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 0,01105247 0,04990978 ! acetyl-CoA catabolic process GO:0046356 37 23 1,000 0,01105247 0,04981769 GO:0006099|tricarboxylic acid cycle, ! cell projection assembly GO:0030031 138 68 2,000 0,01192165 0,05363643 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 0,01200249 0,05390088 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 0,01200249 0,05380198 ! mechanoreceptor differentiation GO:0042490 48 24 1,000 0,01200249 0,05370344 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 0,01200249 0,05360526 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 0,01200249 0,05350744 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 0,01200249 0,05340998 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 0,01200249 0,05331287 ! leukotriene metabolic process GO:0006691 47 24 1,000 0,01200249 0,05321611 ! membrane depolarization GO:0051899 45 24 1,000 0,01200249 0,0531197 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 0,01200249 0,05302365 ! platelet activation GO:0030168 41 24 1,000 0,01200249 0,05292794 ! negative regulation of catabolic process GO:0009895 52 24 1,000 0,01200249 0,05283257 ! lung development GO:0030324 165 69 2,000 0,01240077 0,05448755 ! protein maturation by peptide bond cleavage GO:0051605 118 70 2,000 0,0128908 0,056539 ! leukocyte adhesion GO:0007159 55 25 1,000 0,01298697 0,05685872 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 0,01298697 0,05675701 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 0,01298697 0,05665566 ! receptor metabolic process GO:0043112 53 25 1,000 0,01298697 0,05655467 ! chromosome condensation GO:0030261 48 25 1,000 0,01298697 0,05645403 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 0,01298697 0,05635376 ! interaction with host GO:0051701 66 25 1,000 0,01298697 0,05625384 ! lymphocyte proliferation GO:0046651 55 25 1,000 0,01298697 0,05615428 ! cellular alkene metabolic process GO:0043449 48 25 1,000 0,01298697 0,05605507 ! liver development GO:0001889 55 25 1,000 0,01298697 0,0559562 ! carbohydrate transport GO:0008643 114 72 2,000 0,01390372 0,05980068 ! respiratory tube development GO:0030323 171 72 2,000 0,01390372 0,05969559 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 0,01390372 0,05959086 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 0,0140054 0,05992152 ! myelination GO:0042552 50 26 1,000 0,0140054 0,05981676 ! pyruvate metabolic process GO:0006090 43 26 1,000 0,0140054 0,05971237 ! macromolecular complex disassembly GO:0032984 54 26 1,000 0,0140054 0,05960834 ! microtubule organizing center organization GO:0031023 42 26 1,000 0,0140054 0,05950468 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 1,000 0,0140054 0,05940137 ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 0,0140054 0,05929842 ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,0140054 0,05919583 ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 0,0140054 0,05909359 ! coenzyme catabolic process GO:0009109 42 26 1,000 0,0140054 0,0589917 ! regulation of blood coagulation GO:0030193 46 26 1,000 0,0140054 0,05889017 ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,0140054 0,05878898 GO:0045840|positive regulation of mitosis, ! blastocyst development GO:0001824 50 26 1,000 0,0140054 0,05868815 ! neural tube closure GO:0001843 58 26 1,000 0,0140054 0,05858765 GO:0060606|tube closure, ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 0,0140054 0,0584875 ! respiratory system development GO:0060541 175 74 2,000 0,01496066 0,06237012 ! positive regulation of cell projection organization GO:0031346 66 27 1,000 0,01505726 0,0626659 ! acetyl-CoA metabolic process GO:0006084 41 27 1,000 0,01505726 0,06255932 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 1,000 0,01505726 0,06245311 ! tube lumen formation GO:0035148 59 27 1,000 0,01505726 0,06234726 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 0,01505726 0,06224176 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 0,01505726 0,06213663 ! mitochondrial membrane organization GO:0007006 60 27 1,000 0,01505726 0,06203184 ! response to toxin GO:0009636 49 27 1,000 0,01505726 0,06192741 ! leukocyte proliferation GO:0070661 59 27 1,000 0,01505726 0,06182333 GO:0032943|mononuclear cell proliferation, ! regulation of transcription factor activity GO:0051090 137 75 2,000 0,0155057 0,06355777 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,0155057 0,06345131 ! lymphocyte differentiation GO:0030098 193 76 2,000 0,01606183 0,06561713 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01614204 0,06583473 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 0,01614204 0,065725 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 0,01614204 0,06561564 ! respiratory gaseous exchange GO:0007585 61 29 1,000 0,01725924 0,07004039 ! primary neural tube formation GO:0014020 61 29 1,000 0,01725924 0,06992424 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01725924 0,06980847 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01725924 0,06969309 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 0,01779688 0,0717455 ! development of primary sexual characteristics GO:0045137 143 80 2,000 0,01839751 0,07404467 ! icosanoid biosynthetic process GO:0046456 60 30 1,000 0,01840835 0,07396646 ! immune response-activating signal transduction GO:0002757 58 30 1,000 0,01840835 0,073845 GO:0002764|immune response-regulating signal transduction, ! cell fate determination GO:0001709 64 30 1,000 0,01840835 0,07372394 ! regulation of coagulation GO:0050818 52 30 1,000 0,01840835 0,07360328 ! ovulation cycle process GO:0022602 55 31 1,000 0,01958889 0,07819553 ! male gonad development GO:0008584 56 31 1,000 0,01958889 0,07806797 ! erythrocyte differentiation GO:0030218 62 31 1,000 0,01958889 0,07794082 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01958889 0,07781409 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 1,000 0,01958889 0,07768777 ! eye morphogenesis GO:0048592 65 31 1,000 0,01958889 0,07756185 ! positive regulation of immune effector process GO:0002699 78 31 1,000 0,01958889 0,07743635 ! intracellular protein transmembrane transport GO:0065002 165 83 2,000 0,02026642 0,07998522 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,02080037 0,08196016 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 1,000 0,02080037 0,08182818 ! positive regulation of T cell proliferation GO:0042102 60 32 1,000 0,02080037 0,08169662 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,02080037 0,08156549 ! hexose biosynthetic process GO:0019319 53 32 1,000 0,02080037 0,08143477 ! ovulation cycle GO:0042698 57 32 1,000 0,02080037 0,08130448 ! peripheral nervous system development GO:0007422 68 32 1,000 0,02080037 0,0811746 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,02080037 0,08104513 ! T cell activation GO:0042110 189 84 2,000 0,02091175 0,08134937 ! response to nutrient GO:0007584 135 84 2,000 0,02091175 0,08122003 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,02156827 0,08363697 ! cholesterol homeostasis GO:0042632 60 33 1,000 0,02204229 0,08533966 GO:0055092|sterol homeostasis, ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,02204229 0,08520463 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 1,000 0,02204229 0,08507002 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,0233142 0,08983688 ! post-embryonic development GO:0009791 76 34 1,000 0,0233142 0,0896954 ! cholesterol transport GO:0030301 62 34 1,000 0,0233142 0,08955437 ! regulation of ARF GTPase activity GO:0032312 73 34 1,000 0,0233142 0,08941378 ! cell fate specification GO:0001708 56 34 1,000 0,0233142 0,08927364 ! regulation of DNA binding GO:0051101 167 89 2,000 0,0243063 0,0929269 ! regulation of synaptic plasticity GO:0048167 78 35 1,000 0,0246156 0,09396235 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,0246156 0,09381577 ! telencephalon development GO:0021537 81 35 1,000 0,0246156 0,09366963 ! sterol transport GO:0015918 63 35 1,000 0,0246156 0,09352396 ! placenta development GO:0001890 53 35 1,000 0,0246156 0,09337874 ! regulation of muscle development GO:0048634 82 36 1,000 0,02594603 0,09827312 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,02594603 0,09812099 ! positive regulation of cell development GO:0010720 85 36 1,000 0,02594603 0,09796933 ! regulation of proteolysis GO:0030162 77 36 1,000 0,02594603 0,09781815 ! aerobic respiration GO:0009060 56 36 1,000 0,02594603 0,09766743 ! embryonic organ development GO:0048568 67 36 1,000 0,02594603 0,09751717 ! monosaccharide biosynthetic process GO:0046364 57 36 1,000 0,02594603 0,09736737 ! amine transport GO:0015837 181 93 2,000 0,02722324 0,10200365 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,02730504 0,10215346 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! sister chromatid segregation GO:0000819 65 37 1,000 0,02730504 0,10199726 ! odontogenesis GO:0042476 74 37 1,000 0,02730504 0,10184154 ! tissue remodeling GO:0048771 78 37 1,000 0,02730504 0,1016863 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,02730504 0,10153152 ! female pregnancy GO:0007565 166 94 2,000 0,02798037 0,10388458 ! carbohydrate biosynthetic process GO:0016051 158 94 2,000 0,02798037 0,10372694 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,02869216 0,10620446 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 0,02869216 0,10604378 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,02869216 0,1058836 ! spermatid development GO:0007286 69 38 1,000 0,02869216 0,10572389 ! glycogen metabolic process GO:0005977 63 38 1,000 0,02869216 0,10556467 ! pigment metabolic process GO:0042440 87 38 1,000 0,02869216 0,10540593 ! neural tube formation GO:0001841 79 38 1,000 0,02869216 0,10524766 ! regulation of defense response GO:0031347 171 95 2,000 0,02874864 0,10529675 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 0,02874864 0,10513912 ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,03010694 0,10994207 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,03010694 0,10977797 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 0,03010694 0,10961437 GO:0006073|cellular glucan metabolic process, ! transcription initiation GO:0006352 171 97 2,000 0,03031852 0,11022046 ! leukocyte differentiation GO:0002521 232 98 2,000 0,0311201 0,11296642 ! learning GO:0007612 82 40 1,000 0,03154892 0,11435315 ! lipid homeostasis GO:0055088 75 40 1,000 0,03154892 0,11418374 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,03154892 0,11401483 ! mRNA transport GO:0051028 185 100 2,000 0,03275643 0,11820379 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,03301768 0,11897079 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,03301768 0,11879558 ! maintenance of protein location GO:0045185 95 41 1,000 0,03301768 0,11862088 ! spermatid differentiation GO:0048515 73 41 1,000 0,03301768 0,11844669 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,03301768 0,11827302 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,03426801 0,1225721 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,03426801 0,1223929 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03426801 0,12221423 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,03426801 0,12203607 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03426801 0,12185843 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03426801 0,12168131 ! polyol transport GO:0015791 12 5 0,000 0,03426801 0,12150471 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03426801 0,12132862 ! response to superoxide GO:0000303 10 5 0,000 0,03426801 0,12115303 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03426801 0,12097795 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03426801 0,12080338 GO:0045940|positive regulation of steroid metabolic process, ! tongue development GO:0043586 8 5 0,000 0,03426801 0,12062931 ! female meiosis GO:0007143 10 5 0,000 0,03426801 0,12045575 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,03426801 0,12028268 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03426801 0,12011011 ! hypothalamus development GO:0021854 9 5 0,000 0,03426801 0,11993803 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03426801 0,11976644 ! cobalt ion transport GO:0006824 11 5 0,000 0,03426801 0,11959535 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03426801 0,11942474 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03426801 0,11925462 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03426801 0,11908498 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03426801 0,11891583 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03426801 0,11874716 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03426801 0,11857896 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03426801 0,11841124 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,03426801 0,11824399 ! transposition GO:0032196 9 5 0,000 0,03426801 0,11807721 ! negative chemotaxis GO:0050919 16 5 0,000 0,03426801 0,11791091 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03426801 0,11774507 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03426801 0,1175797 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03426801 0,11741479 ! behavioral response to pain GO:0048266 10 5 0,000 0,03426801 0,11725034 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03426801 0,11708636 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03426801 0,11692283 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03426801 0,11675976 ! micturition GO:0060073 9 5 0,000 0,03426801 0,11659714 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03426801 0,11643497 ! copulation GO:0007620 9 5 0,000 0,03426801 0,11627326 ! glial cell fate commitment GO:0021781 14 5 0,000 0,03426801 0,11611199 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03426801 0,11595117 ! bioluminescence GO:0008218 9 5 0,000 0,03426801 0,11579079 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03426801 0,11563086 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03426801 0,11547137 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03426801 0,11531232 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03426801 0,11515371 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03426801 0,11499553 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03426801 0,11483778 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03426801 0,11468047 ! grooming behavior GO:0007625 6 5 0,000 0,03426801 0,11452359 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03426801 0,11436714 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03426801 0,11421111 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03426801 0,11405551 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03426801 0,11390033 ! response to protozoan GO:0001562 13 5 0,000 0,03426801 0,11374558 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,03426801 0,11359124 ! lymph vessel development GO:0001945 10 5 0,000 0,03426801 0,11343732 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03426801 0,11328382 ! endochondral ossification GO:0001958 17 5 0,000 0,03426801 0,11313074 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03426801 0,11297806 ! single strand break repair GO:0000012 8 5 0,000 0,03426801 0,1128258 ! parathyroid gland development GO:0060017 14 5 0,000 0,03426801 0,11267395 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03426801 0,11252251 ! cytokine secretion GO:0050663 15 5 0,000 0,03426801 0,11237147 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03426801 0,11222084 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03426801 0,11207061 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,03426801 0,11192078 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,03426801 0,11177135 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03426801 0,11162233 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03426801 0,11147369 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03426801 0,11132546 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03426801 0,11117762 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03426801 0,11103017 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,03426801 0,11088311 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03426801 0,11073643 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03426801 0,11059015 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03426801 0,11044425 ! microvillus organization GO:0032528 8 5 0,000 0,03426801 0,11029874 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03426801 0,11015361 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,03426801 0,11000886 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03426801 0,10986449 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03426801 0,1097205 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03426801 0,10957689 ! polyol catabolic process GO:0046174 9 5 0,000 0,03426801 0,10943365 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03426801 0,10929079 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03426801 0,1091483 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03426801 0,10900618 ! muscle cell migration GO:0014812 8 5 0,000 0,03426801 0,10886443 ! mitochondrial fission GO:0000266 8 5 0,000 0,03426801 0,10872304 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03426801 0,10858203 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,03426801 0,10844138 ! mRNA transcription GO:0009299 10 5 0,000 0,03426801 0,10830109 ! nerve growth factor processing GO:0032455 9 5 0,000 0,03426801 0,10816117 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,03426801 0,10802161 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03426801 0,1078824 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03426801 0,10774356 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03426801 0,10760507 ! monocyte activation GO:0042117 10 5 0,000 0,03426801 0,10746694 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03426801 0,10732916 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03426801 0,10719173 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,03426801 0,10705466 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03426801 0,10691794 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03426801 0,10678156 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03426801 0,10664553 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,03426801 0,10650985 ! forebrain neuron development GO:0021884 13 5 0,000 0,03426801 0,10637452 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03426801 0,10623952 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,03426801 0,10610487 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03426801 0,10597056 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03426801 0,10583659 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,03426801 0,10570296 ! lipid glycosylation GO:0030259 7 5 0,000 0,03426801 0,10556967 ! nucleobase transport GO:0015851 6 5 0,000 0,03426801 0,10543671 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03426801 0,10530408 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03426801 0,10517179 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03426801 0,10503983 ! basic amino acid transport GO:0015802 12 5 0,000 0,03426801 0,1049082 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,03426801 0,1047769 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03426801 0,10464593 ! actin nucleation GO:0045010 11 5 0,000 0,03426801 0,10451529 ! depurination GO:0045007 5 5 0,000 0,03426801 0,10438497 ! depyrimidination GO:0045008 10 5 0,000 0,03426801 0,10425497 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03426801 0,1041253 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03426801 0,10399596 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,03426801 0,10386693 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03426801 0,10373822 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03426801 0,10360983 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03426801 0,10348176 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03426801 0,10335401 ! activated T cell proliferation GO:0050798 16 5 0,000 0,03426801 0,10322657 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03426801 0,10309944 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03426801 0,10297263 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03426801 0,10284612 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03426801 0,10271993 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03426801 0,10259405 ! response to arsenic GO:0046685 11 5 0,000 0,03426801 0,10246848 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,03426801 0,10234321 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03426801 0,10221825 GO:0002448|mast cell mediated immunity, ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03426801 0,10209359 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03426801 0,10196924 ! response to mercury ion GO:0046689 8 5 0,000 0,03426801 0,10184519 ! response to cadmium ion GO:0046686 7 5 0,000 0,03426801 0,10172144 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03426801 0,10159799 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03426801 0,10147484 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03426801 0,10135199 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03426801 0,10122944 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03426801 0,10110718 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03426801 0,10098522 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03426801 0,10086355 ! decidualization GO:0046697 11 5 0,000 0,03426801 0,10074217 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03426801 0,10062109 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03426801 0,10050029 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03426801 0,10037979 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03426801 0,10025957 ! embryonic cleavage GO:0040016 6 5 0,000 0,03426801 0,10013965 ! peroxisome fission GO:0016559 5 5 0,000 0,03426801 0,10002001 ! histone demethylation GO:0016577 13 5 0,000 0,03426801 0,09990065 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03426801 0,09978158 ! mitotic recombination GO:0006312 9 5 0,000 0,03426801 0,09966279 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03426801 0,09954429 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03426801 0,09942606 ! metaphase plate congression GO:0051310 7 5 0,000 0,03426801 0,09930812 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03426801 0,09919046 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03426801 0,09907307 ! enteric nervous system development GO:0048484 8 5 0,000 0,03426801 0,09895596 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03426801 0,09883913 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03426801 0,09872258 GO:0031295|T cell costimulation, ! muscle cell proliferation GO:0033002 12 5 0,000 0,03426801 0,09860629 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03426801 0,09849029 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,03426801 0,09837455 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03426801 0,09825909 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03426801 0,0981439 ! metaphase GO:0051323 11 5 0,000 0,03426801 0,09802897 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03426801 0,09791432 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03426801 0,09779994 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03426801 0,09768582 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03426801 0,09757196 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03426801 0,09745838 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03426801 0,09734505 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03426801 0,09723199 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03426801 0,09711919 ! response to redox state GO:0051775 6 5 0,000 0,03426801 0,09700666 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03426801 0,09689438 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03426801 0,09678236 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03426801 0,09667061 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03426801 0,09655911 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03426801 0,09644786 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03426801 0,09633688 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03426801 0,09622614 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03426801 0,09611567 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03426801 0,09600544 ! striatum development GO:0021756 14 5 0,000 0,03426801 0,09589547 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,03426801 0,09578575 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03426801 0,09567628 ! glial cell migration GO:0008347 10 5 0,000 0,03426801 0,09556706 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03426801 0,09545809 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03426801 0,09534937 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03426801 0,09524089 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03426801 0,09513266 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03426801 0,09502468 ! neuroprotection GO:0043526 8 5 0,000 0,03426801 0,09491694 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,03426801 0,09480945 ! regulation of sensory perception GO:0051931 8 5 0,000 0,03426801 0,0947022 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03426801 0,09459519 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03426801 0,09448842 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03426801 0,0943819 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03426801 0,09427561 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03426801 0,09416957 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,03426801 0,09406376 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,03426801 0,09395819 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03426801 0,09385285 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03426801 0,09374775 ! spindle assembly GO:0051225 6 5 0,000 0,03426801 0,09364289 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,03426801 0,09353826 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03426801 0,09343387 ! protein palmitoylation GO:0018345 12 5 0,000 0,03426801 0,0933297 ! drug metabolic process GO:0017144 7 5 0,000 0,03426801 0,09322577 ! organ regeneration GO:0031100 7 5 0,000 0,03426801 0,09312207 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03426801 0,0930186 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03426801 0,09291537 ! ear morphogenesis GO:0042471 64 42 1,000 0,03451277 0,09347527 ! alcohol biosynthetic process GO:0046165 65 42 1,000 0,03451277 0,09337176 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,03451277 0,09326847 ! protein amino acid N-linked glycosylation GO:0006487 71 43 1,000 0,03603375 0,09727123 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,03603375 0,09716386 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,03603375 0,09705674 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,0375802 0,10111062 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 1,000 0,0375802 0,10099938 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,0375802 0,1008884 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,0375802 0,10077765 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 0,0375802 0,10066715 ! B cell differentiation GO:0030183 124 45 1,000 0,0391517 0,10476188 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 1,000 0,04074782 0,10891348 ! cell growth GO:0016049 90 46 1,000 0,04074782 0,10879444 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,04074782 0,10867567 ! polysaccharide biosynthetic process GO:0000271 79 46 1,000 0,04074782 0,10855716 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04097995 0,10905667 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04097995 0,108938 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,04097995 0,10881959 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,04097995 0,10870144 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04097995 0,10858354 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,04097995 0,1084659 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,04097995 0,10834851 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04097995 0,10823138 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,04097995 0,1081145 ! response to oxygen radical GO:0000305 11 6 0,000 0,04097995 0,10799787 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,04097995 0,10788149 ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,04097995 0,10776537 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04097995 0,10764949 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,04097995 0,10753386 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,04097995 0,10741848 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04097995 0,10730335 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04097995 0,10718846 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,04097995 0,10707382 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04097995 0,10695943 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,04097995 0,10684528 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,04097995 0,10673137 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04097995 0,10661771 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,04097995 0,10650428 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,04097995 0,1063911 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04097995 0,10627816 ! malate metabolic process GO:0006108 13 6 0,000 0,04097995 0,10616546 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,04097995 0,10605299 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,04097995 0,10594077 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,04097995 0,10582878 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,04097995 0,10571703 ! protein refolding GO:0042026 15 6 0,000 0,04097995 0,10560551 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04097995 0,10549423 ! opsonization GO:0008228 8 6 0,000 0,04097995 0,10538318 ! mating behavior GO:0007617 7 6 0,000 0,04097995 0,10527237 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,04097995 0,10516179 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,04097995 0,10505144 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,04097995 0,10494133 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,04097995 0,10483144 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04097995 0,10472178 ! response to interferon-gamma GO:0034341 16 6 0,000 0,04097995 0,10461236 ! toxin metabolic process GO:0009404 11 6 0,000 0,04097995 0,10450316 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04097995 0,10439419 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,04097995 0,10428544 ! nuclear migration GO:0007097 13 6 0,000 0,04097995 0,10417693 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,04097995 0,10406863 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,04097995 0,10396057 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04097995 0,10385272 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,04097995 0,1037451 ! thymic T cell selection GO:0045061 16 6 0,000 0,04097995 0,10363771 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,04097995 0,10353053 ! protein lipoylation GO:0009249 10 6 0,000 0,04097995 0,10342358 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,04097995 0,10331685 GO:0070633|transepithelial transport, ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04097995 0,10321034 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,04097995 0,10310404 ! glutamate catabolic process GO:0006538 12 6 0,000 0,04097995 0,10299797 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,04097995 0,10289211 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04097995 0,10278647 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,04097995 0,10268105 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04097995 0,10257585 ! hyperosmotic response GO:0006972 10 6 0,000 0,04097995 0,10247085 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,04097995 0,10236608 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,04097995 0,10226152 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,04097995 0,10215717 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,04097995 0,10205303 ! urea metabolic process GO:0019627 7 6 0,000 0,04097995 0,10194911 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04097995 0,1018454 ! neutrophil activation GO:0042119 7 6 0,000 0,04097995 0,1017419 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04097995 0,1016386 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,04097995 0,10153552 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04097995 0,10143265 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,04097995 0,10132999 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,04097995 0,10122753 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04097995 0,10112528 ! neuron apoptosis GO:0051402 15 6 0,000 0,04097995 0,10102323 ! T cell mediated immunity GO:0002456 17 6 0,000 0,04097995 0,1009214 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04097995 0,10081976 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,04097995 0,10071834 ! carnitine transport GO:0015879 10 6 0,000 0,04097995 0,10061711 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04097995 0,10051609 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,04097995 0,10041527 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,04097995 0,10031465 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,04097995 0,10021424 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,04097995 0,10011403 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,04097995 0,10001401 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,04097995 0,0999142 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,04097995 0,09981458 GO:0045686|negative regulation of glial cell differentiation, ! astrocyte development GO:0014002 16 6 0,000 0,04097995 0,09971516 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,04097995 0,09961595 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04097995 0,09951692 ! interaction with symbiont GO:0051702 14 6 0,000 0,04097995 0,0994181 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04097995 0,09931947 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,04097995 0,09922104 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,04097995 0,0991228 ! response to copper ion GO:0046688 10 6 0,000 0,04097995 0,09902475 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,04097995 0,0989269 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,04097995 0,09882925 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04097995 0,09873178 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,04097995 0,09863451 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04097995 0,09853743 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,04097995 0,09844054 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04097995 0,09834384 ! Schwann cell development GO:0014044 15 6 0,000 0,04097995 0,09824733 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,04097995 0,09815101 ! response to pheromone GO:0019236 6 6 0,000 0,04097995 0,09805487 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,04097995 0,09795893 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,04097995 0,09786317 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,04097995 0,0977676 ! subpallium development GO:0021544 15 6 0,000 0,04097995 0,09767222 ! neural tube patterning GO:0021532 8 6 0,000 0,04097995 0,09757702 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,04097995 0,09748201 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04097995 0,09738718 ! G2 phase GO:0051319 16 6 0,000 0,04097995 0,09729254 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,04097995 0,09719808 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,04097995 0,09710381 ! oxygen homeostasis GO:0032364 10 6 0,000 0,04097995 0,09700971 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04097995 0,0969158 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04097995 0,09682207 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,04097995 0,09672853 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04097995 0,09663516 ! receptor internalization GO:0031623 11 6 0,000 0,04097995 0,09654197 ! plasminogen activation GO:0031639 9 6 0,000 0,04097995 0,09644896 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,04097995 0,09635614 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04097995 0,09626349 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,04097995 0,09617101 ! protein deubiquitination GO:0016579 16 6 0,000 0,04097995 0,09607872 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,04097995 0,0959866 ! protein destabilization GO:0031648 9 6 0,000 0,04097995 0,09589466 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,04097995 0,0958029 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04097995 0,09571131 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,04097995 0,09561989 ! regulation of viral transcription GO:0046782 11 6 0,000 0,04097995 0,09552865 ! progesterone metabolic process GO:0042448 12 6 0,000 0,04097995 0,09543758 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,04097995 0,09534669 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,04097995 0,09525597 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,04097995 0,09516542 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,04097995 0,09507505 ! determination of adult lifespan GO:0008340 17 6 0,000 0,04097995 0,09498484 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04097995 0,09489481 ! neural plate development GO:0001840 9 6 0,000 0,04097995 0,09480495 ! catecholamine transport GO:0051937 9 6 0,000 0,04097995 0,09471526 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,04097995 0,09462573 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04097995 0,09453638 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,04097995 0,09444719 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,04097995 0,09435818 ! maternal placenta development GO:0001893 12 6 0,000 0,04097995 0,09426933 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,04097995 0,09418064 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04097995 0,09409213 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,04097995 0,09400378 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,04097995 0,0939156 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,04097995 0,09382758 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,04097995 0,09373972 GO:0055081|anion homeostasis, ! regulation of JNK cascade GO:0046328 104 47 1,000 0,04236814 0,09682448 ! mitochondrial transport GO:0006839 94 48 1,000 0,04401227 0,10048782 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,04401227 0,10039399 ! endosome transport GO:0016197 127 48 1,000 0,04401227 0,10030034 ! male sex differentiation GO:0046661 93 48 1,000 0,04401227 0,10020687 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,04401227 0,10011356 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,04401227 0,10002044 ! methylation GO:0032259 97 48 1,000 0,04401227 0,09992748 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,04567978 0,10361719 ! protein homooligomerization GO:0051260 84 49 1,000 0,04567978 0,10352107 ! endocrine system development GO:0035270 109 50 1,000 0,04737029 0,10725266 ! regulation of ossification GO:0030278 123 50 1,000 0,04737029 0,10715335 ! tRNA transcription GO:0009304 17 7 0,000 0,04764544 0,10767604 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04764544 0,10757653 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,04764544 0,10747719 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04764544 0,10737805 ! regulation of helicase activity GO:0051095 16 7 0,000 0,04764544 0,10727908 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04764544 0,1071803 ! sleep GO:0030431 16 7 0,000 0,04764544 0,10708169 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04764544 0,10698327 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04764544 0,10688503 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04764544 0,10678697 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04764544 0,10668909 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04764544 0,10659139 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04764544 0,10649387 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04764544 0,10639653 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04764544 0,10629936 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04764544 0,10620237 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04764544 0,10610556 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04764544 0,10600893 ! glycolipid transport GO:0046836 11 7 0,000 0,04764544 0,10591247 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04764544 0,10581618 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04764544 0,10572007 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,04764544 0,10562414 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04764544 0,10552838 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04764544 0,10543279 ! mRNA stabilization GO:0048255 18 7 0,000 0,04764544 0,10533738 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,04764544 0,10524214 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04764544 0,10514707 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04764544 0,10505217 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04764544 0,10495744 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04764544 0,10486288 ! lipoprotein transport GO:0042953 14 7 0,000 0,04764544 0,1047685 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04764544 0,10467428 ! rhythmic behavior GO:0007622 17 7 0,000 0,04764544 0,10458023 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04764544 0,10448636 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04764544 0,10439265 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04764544 0,10429911 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04764544 0,10420573 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04764544 0,10411252 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04764544 0,10401948 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04764544 0,10392661 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04764544 0,1038339 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04764544 0,10374136 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04764544 0,10364898 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04764544 0,10355676 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04764544 0,10346471 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04764544 0,10337283 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04764544 0,1032811 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04764544 0,10318954 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04764544 0,10309814 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04764544 0,1030069 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04764544 0,10291583 ! adrenal gland development GO:0030325 17 7 0,000 0,04764544 0,10282491 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04764544 0,10273416 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04764544 0,10264356 ! ovulation GO:0030728 10 7 0,000 0,04764544 0,10255313 ! adenohypophysis development GO:0021984 11 7 0,000 0,04764544 0,10246285 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04764544 0,10237274 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04764544 0,10228278 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04764544 0,10219298 ! microtubule nucleation GO:0007020 21 7 0,000 0,04764544 0,10210333 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04764544 0,10201385 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04764544 0,10192452 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04764544 0,10183535 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04764544 0,10174633 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04764544 0,10165747 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04764544 0,10156876 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04764544 0,10148021 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04764544 0,10139181 ! galactose metabolic process GO:0006012 13 7 0,000 0,04764544 0,10130357 ! vesicle fusion GO:0006906 20 7 0,000 0,04764544 0,10121548 ! response to dietary excess GO:0002021 8 7 0,000 0,04764544 0,10112754 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04764544 0,10103976 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04764544 0,10095213 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04764544 0,10086465 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,04764544 0,10077732 ! nucleoside transport GO:0015858 11 7 0,000 0,04764544 0,10069014 ! nucleoside salvage GO:0043174 11 7 0,000 0,04764544 0,10060311 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04764544 0,10051624 ! male sex determination GO:0030238 15 7 0,000 0,04764544 0,10042951 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04764544 0,10034293 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04764544 0,1002565 ! parturition GO:0007567 16 7 0,000 0,04764544 0,10017022 ! rRNA modification GO:0000154 14 7 0,000 0,04764544 0,10008409 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04764544 0,09999811 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,04764544 0,09991228 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04764544 0,09982659 ! monocyte differentiation GO:0030224 16 7 0,000 0,04764544 0,09974105 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04764544 0,09965565 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04764544 0,0995704 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,04764544 0,0994853 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04764544 0,09940034 ! fibrinolysis GO:0042730 11 7 0,000 0,04764544 0,09931553 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04764544 0,09923086 ! eating behavior GO:0042755 8 7 0,000 0,04764544 0,09914634 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04764544 0,09906196 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04764544 0,09897772 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04764544 0,09889363 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04764544 0,09880968 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04764544 0,09872587 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04764544 0,0986422 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04764544 0,09855868 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04764544 0,0984753 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04764544 0,09839206 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04764544 0,09830895 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04764544 0,09822599 ! histone ubiquitination GO:0016574 9 7 0,000 0,04764544 0,09814317 ! regulation of meiosis GO:0040020 12 7 0,000 0,04764544 0,09806049 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04764544 0,09797795 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04764544 0,09789554 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04764544 0,09781328 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04764544 0,09773115 ! transcription termination GO:0006353 14 7 0,000 0,04764544 0,09764916 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04764544 0,09756731 ! anaphase GO:0051322 18 7 0,000 0,04764544 0,0974856 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04764544 0,09740402 ! axonal fasciculation GO:0007413 19 7 0,000 0,04764544 0,09732258 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04764544 0,09724127 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04764544 0,0971601 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04764544 0,09707907 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04764544 0,09699817 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04764544 0,0969174 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04764544 0,09683677 ! antibiotic transport GO:0042891 9 7 0,000 0,04764544 0,09675628 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04764544 0,09667591 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04764544 0,09659569 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04764544 0,09651559 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04764544 0,09643563 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04764544 0,0963558 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04764544 0,0962761 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04764544 0,09619653 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04764544 0,09611709 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04764544 0,09603779 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04764544 0,09595862 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04764544 0,09587957 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04764544 0,09580066 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04764544 0,09572188 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04764544 0,09564322 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04764544 0,0955647 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04764544 0,0954863 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04764544 0,09540803 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04764544 0,09532989 ! muscle adaptation GO:0043500 13 7 0,000 0,04764544 0,09525188 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04764544 0,095174 ! retina homeostasis GO:0001895 12 7 0,000 0,04764544 0,09509624 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04764544 0,09501861 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04764544 0,09494111 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04764544 0,09486373 ! regulation of cell projection organization GO:0031344 135 51 1,000 0,04908339 0,09764716 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,04908339 0,09756771 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,05081869 0,100935 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,05081869 0,10085301 ! cellular amino acid biosynthetic process GO:0008652 80 52 1,000 0,05081869 0,10077115 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,05081869 0,10068942 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,05081869 0,10060782 ! histone modification GO:0016570 104 52 1,000 0,05081869 0,10052636 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,05081869 0,10044503 ! inner ear development GO:0048839 89 53 1,000 0,0525758 0,10383402 ! synapse organization GO:0050808 102 53 1,000 0,0525758 0,10375014 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,05426478 0,10699665 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,05426478 0,10691037 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,05426478 0,10682422 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,05426478 0,10673821 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,05426478 0,10665234 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05426478 0,1065666 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05426478 0,10648101 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,05426478 0,10639555 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,05426478 0,10631023 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,05426478 0,10622504 ! meiotic prophase I GO:0007128 14 8 0,000 0,05426478 0,10614 ! response to zinc ion GO:0010043 12 8 0,000 0,05426478 0,10605508 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,05426478 0,10597031 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05426478 0,10588567 ! oligopeptide transport GO:0006857 16 8 0,000 0,05426478 0,10580116 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,05426478 0,10571679 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,05426478 0,10563255 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,05426478 0,10554845 ! signal peptide processing GO:0006465 12 8 0,000 0,05426478 0,10546448 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,05426478 0,10538065 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,05426478 0,10529695 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05426478 0,10521338 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,05426478 0,10512994 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,05426478 0,10504664 ! estrogen metabolic process GO:0008210 17 8 0,000 0,05426478 0,10496346 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,05426478 0,10488042 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,05426478 0,10479751 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,05426478 0,10471474 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05426478 0,10463209 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05426478 0,10454957 ! reflex GO:0060004 17 8 0,000 0,05426478 0,10446718 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05426478 0,10438493 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,05426478 0,1043028 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05426478 0,1042208 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,05426478 0,10413893 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,05426478 0,10405719 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,05426478 0,10397557 ! astrocyte differentiation GO:0048708 19 8 0,000 0,05426478 0,10389409 ! histidine catabolic process GO:0006548 10 8 0,000 0,05426478 0,10381273 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05426478 0,1037315 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,05426478 0,1036504 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,05426478 0,10356942 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,05426478 0,10348857 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,05426478 0,10340784 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,05426478 0,10332724 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,05426478 0,10324677 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,05426478 0,10316642 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,05426478 0,1030862 ! macrophage activation GO:0042116 13 8 0,000 0,05426478 0,1030061 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05426478 0,10292613 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,05426478 0,10284628 ! purine salvage GO:0043101 12 8 0,000 0,05426478 0,10276655 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,05426478 0,10268695 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05426478 0,10260747 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,05426478 0,10252812 ! osteoblast development GO:0002076 17 8 0,000 0,05426478 0,10244888 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,05426478 0,10236977 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,05426478 0,10229078 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,05426478 0,10221192 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,05426478 0,10213317 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05426478 0,10205455 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,05426478 0,10197604 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05426478 0,10189766 ! intermediate filament organization GO:0045109 12 8 0,000 0,05426478 0,1018194 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,05426478 0,10174126 ! cellular extravasation GO:0045123 13 8 0,000 0,05426478 0,10166323 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,05426478 0,10158533 ! response to antibiotic GO:0046677 11 8 0,000 0,05426478 0,10150755 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,05426478 0,10142988 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,05426478 0,10135234 ! response to tropane GO:0014073 15 8 0,000 0,05426478 0,10127491 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05426478 0,1011976 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,05426478 0,10112041 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05426478 0,10104333 ! mast cell activation GO:0045576 14 8 0,000 0,05426478 0,10096638 ! multicellular organismal aging GO:0010259 20 8 0,000 0,05426478 0,10088954 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,05426478 0,10081282 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,05426478 0,10073621 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,05426478 0,10065972 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05426478 0,10058335 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05426478 0,10050709 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,05426478 0,10043095 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05426478 0,10035492 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,05426478 0,10027901 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,05426478 0,10020322 ! intracellular lipid transport GO:0032365 16 8 0,000 0,05426478 0,10012753 ! response to tumor cell GO:0002347 16 8 0,000 0,05426478 0,10005197 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05426478 0,09997651 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,05426478 0,09990117 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,05426478 0,09982595 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,05426478 0,09975083 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05426478 0,09967583 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,05426478 0,09960094 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,05426478 0,09952617 ! hormone catabolic process GO:0042447 17 8 0,000 0,05426478 0,0994515 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,05426478 0,09937695 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,05426478 0,09930251 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,05426478 0,09922819 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,05426478 0,09915397 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05426478 0,09907986 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,05426478 0,09900587 ! adult feeding behavior GO:0008343 10 8 0,000 0,05426478 0,09893198 ! ATP catabolic process GO:0006200 11 8 0,000 0,05426478 0,09885821 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05426478 0,09878454 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05426478 0,09871099 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,05426478 0,09863754 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05426478 0,0985642 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,05426478 0,09849098 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,05426478 0,09841786 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,05426478 0,09834485 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,05426478 0,09827195 GO:0006043|glucosamine catabolic process, ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,05426478 0,09819915 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,05426478 0,09812647 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05426478 0,09805389 ! protein prenylation GO:0018342 21 8 0,000 0,05426478 0,09798142 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,05426478 0,09790905 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,05426478 0,09783679 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,05435434 0,097926 ! embryonic skeletal system development GO:0048706 101 54 1,000 0,05435434 0,09785383 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,05435434 0,09778177 ! covalent chromatin modification GO:0016569 115 54 1,000 0,05435434 0,09770982 ! regulation of cell shape GO:0008360 142 54 1,000 0,05435434 0,09763798 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,05615393 0,1007965 ! RNA elongation GO:0006354 90 56 1,000 0,05797418 0,10398747 ! chloride transport GO:0006821 102 57 1,000 0,05981474 0,10721014 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,05981474 0,10713154 ! heart morphogenesis GO:0003007 105 57 1,000 0,05981474 0,10705306 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,05981474 0,10697469 ! axon extension GO:0048675 16 9 0,000 0,0608383 0,10872565 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,0608383 0,10864617 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,0608383 0,10856681 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,0608383 0,10848757 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,0608383 0,10840843 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,0608383 0,10832942 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,0608383 0,10825052 ! reproductive behavior GO:0019098 22 9 0,000 0,0608383 0,10817174 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,0608383 0,10809306 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,0608383 0,10801451 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,0608383 0,10793607 ! UTP metabolic process GO:0046051 10 9 0,000 0,0608383 0,10785774 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,0608383 0,10777952 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,0608383 0,10770142 ! artery development GO:0060840 25 9 0,000 0,0608383 0,10762344 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,0608383 0,10754556 ! regulation of glycolysis GO:0006110 20 9 0,000 0,0608383 0,1074678 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,0608383 0,10739015 ! equilibrioception GO:0050957 20 9 0,000 0,0608383 0,10731261 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,0608383 0,10723518 ! chemosensory behavior GO:0007635 21 9 0,000 0,0608383 0,10715787 ! microtubule bundle formation GO:0001578 22 9 0,000 0,0608383 0,10708067 ! leukocyte degranulation GO:0043299 16 9 0,000 0,0608383 0,10700357 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,0608383 0,10692659 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,0608383 0,10684972 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,0608383 0,10677296 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,0608383 0,10669631 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,0608383 0,10661977 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,0608383 0,10654334 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,0608383 0,10646702 ! protein targeting to ER GO:0045047 25 9 0,000 0,0608383 0,10639081 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,0608383 0,10631471 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,0608383 0,10623872 ! glycine catabolic process GO:0006546 15 9 0,000 0,0608383 0,10616283 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,0608383 0,10608706 ! endosome organization GO:0007032 20 9 0,000 0,0608383 0,10601139 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,0608383 0,10593583 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,0608383 0,10586037 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,0608383 0,10578503 ! mannose metabolic process GO:0006013 13 9 0,000 0,0608383 0,10570979 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,0608383 0,10563466 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,0608383 0,10555963 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,0608383 0,10548472 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,0608383 0,1054099 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,0608383 0,1053352 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,0608383 0,1052606 ! retinol metabolic process GO:0042572 20 9 0,000 0,0608383 0,1051861 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,0608383 0,10511171 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,0608383 0,10503743 GO:0007351|tripartite regional subdivision, ! macrophage differentiation GO:0030225 15 9 0,000 0,0608383 0,10496325 ! oligodendrocyte development GO:0014003 11 9 0,000 0,0608383 0,10488918 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,0608383 0,10481521 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,0608383 0,10474134 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,0608383 0,10466758 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,0608383 0,10459392 ! response to amine stimulus GO:0014075 13 9 0,000 0,0608383 0,10452037 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,0608383 0,10444692 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,0608383 0,10437357 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,0608383 0,10430033 ! renal water homeostasis GO:0003091 15 9 0,000 0,0608383 0,10422718 ! postreplication repair GO:0006301 25 9 0,000 0,0608383 0,10415414 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,0608383 0,10408121 ! icosanoid secretion GO:0032309 15 9 0,000 0,0608383 0,10400837 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,0608383 0,10393564 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,0608383 0,10386301 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,0608383 0,10379048 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,0608383 0,10371805 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,0608383 0,10364572 ! sterol catabolic process GO:0016127 14 9 0,000 0,0608383 0,10357349 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,0608383 0,10350137 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,0608383 0,10342934 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,0608383 0,10335742 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,0608383 0,10328559 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,0608383 0,10321386 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,0608383 0,10314224 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,0608383 0,10307071 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,0608383 0,10299928 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,0608383 0,10292795 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,0608383 0,10285672 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,0608383 0,10278559 ! purine base metabolic process GO:0006144 25 9 0,000 0,0608383 0,10271456 ! pigment granule transport GO:0051904 17 9 0,000 0,0608383 0,10264362 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,0608383 0,10257278 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,0608383 0,10250204 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,0608383 0,1024314 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,0608383 0,10236086 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,0608383 0,10229041 ! mitochondrion localization GO:0051646 18 9 0,000 0,0608383 0,10222006 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,06167524 0,10355506 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,06167524 0,10348393 ! establishment of organelle localization GO:0051656 122 59 1,000 0,0635553 0,10656527 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,06736631 0,11287785 ! regulation of developmental growth GO:0048638 16 10 0,000 0,06736631 0,11280048 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,06736631 0,11272322 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,06736631 0,11264606 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,06736631 0,11256901 ! associative learning GO:0008306 21 10 0,000 0,06736631 0,11249207 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,06736631 0,11241523 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,06736631 0,1123385 ! phosphate transport GO:0006817 24 10 0,000 0,06736631 0,11226187 ! cell volume homeostasis GO:0006884 17 10 0,000 0,06736631 0,11218534 ! CTP metabolic process GO:0046036 11 10 0,000 0,06736631 0,11210892 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,06736631 0,11203261 ! GTP metabolic process GO:0046039 11 10 0,000 0,06736631 0,11195639 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,06736631 0,11188029 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,06736631 0,11180428 ! social behavior GO:0035176 29 10 0,000 0,06736631 0,11172838 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,06736631 0,11165258 GO:0048200|Golgi transport vesicle coating, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,06736631 0,11157688 ! androgen metabolic process GO:0008209 17 10 0,000 0,06736631 0,11150129 ! phospholipid efflux GO:0033700 19 10 0,000 0,06736631 0,1114258 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,06736631 0,11135041 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,06736631 0,11127512 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,06736631 0,11119993 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,06736631 0,11112485 ! lung alveolus development GO:0048286 26 10 0,000 0,06736631 0,11104986 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06736631 0,11097498 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,06736631 0,1109002 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,06736631 0,11082552 ! endoderm development GO:0007492 18 10 0,000 0,06736631 0,11075094 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,06736631 0,11067646 ! arginine catabolic process GO:0006527 17 10 0,000 0,06736631 0,11060208 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,06736631 0,1105278 ! proline metabolic process GO:0006560 13 10 0,000 0,06736631 0,11045362 ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,06736631 0,11037954 ! V(D)J recombination GO:0033151 34 10 0,000 0,06736631 0,11030556 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,06736631 0,11023168 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,06736631 0,1101579 GO:0021952|central nervous system projection neuron axonogenesis, ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,06736631 0,11008421 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,06736631 0,11001063 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,06736631 0,10993714 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,06736631 0,10986375 ! ruffle organization GO:0031529 17 10 0,000 0,06736631 0,10979046 ! epithelial cell development GO:0002064 21 10 0,000 0,06736631 0,10971727 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,06736631 0,10964417 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,06736631 0,10957117 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,06736631 0,10949827 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,06736631 0,10942547 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,06736631 0,10935276 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,06736631 0,10928015 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,06736631 0,10920763 ! regulation of bone resorption GO:0045124 25 10 0,000 0,06736631 0,10913521 ! protein heterooligomerization GO:0051291 17 10 0,000 0,06736631 0,10906289 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,06736631 0,10899066 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,06736631 0,10891853 ! segment specification GO:0007379 15 10 0,000 0,06736631 0,10884649 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,06736631 0,10877455 ! blastoderm segmentation GO:0007350 19 10 0,000 0,06736631 0,10870271 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,06736631 0,10863096 ! response to dsRNA GO:0043331 23 10 0,000 0,06736631 0,1085593 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,06736631 0,10848774 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,06736631 0,10841627 ! melanosome localization GO:0032400 16 10 0,000 0,06736631 0,1083449 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,06736631 0,10827362 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,06736631 0,10820243 ! induction of an organ GO:0001759 17 10 0,000 0,06736631 0,10813134 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,06736631 0,10806034 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,06736631 0,10798944 ! protein sumoylation GO:0016925 17 10 0,000 0,06736631 0,10791862 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,06736631 0,1078479 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,06736631 0,10777728 ! salivary gland development GO:0007431 28 10 0,000 0,06736631 0,10770674 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,06736631 0,1076363 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,06736631 0,10756595 ! midbrain development GO:0030901 14 10 0,000 0,06736631 0,10749569 ! musculoskeletal movement GO:0050881 16 10 0,000 0,06736631 0,10742552 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,06736631 0,10735545 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,06736631 0,10728546 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,06736631 0,10721557 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,06736631 0,10714577 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,06736631 0,10707606 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,06736631 0,10700644 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,06736631 0,10693691 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,06736631 0,10686747 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,06736631 0,10679812 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,06736631 0,10672886 ! blastocyst formation GO:0001825 18 10 0,000 0,06736631 0,10665969 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,06736631 0,10659061 ! cerebellar cortex development GO:0021695 16 10 0,000 0,06736631 0,10652162 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,06736631 0,10645272 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,06736631 0,1063839 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,06736631 0,10631518 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,06736631 0,10624655 ! camera-type eye development GO:0043010 126 61 1,000 0,0673727 0,10618807 ! viral reproductive process GO:0022415 132 62 1,000 0,06930933 0,10917002 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,07126412 0,11217671 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,07384913 0,11617091 ! respiratory burst GO:0045730 17 11 0,000 0,07384913 0,11609616 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,07384913 0,1160215 ! telencephalon cell migration GO:0022029 23 11 0,000 0,07384913 0,11594693 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,07384913 0,11587247 ! thyroid gland development GO:0030878 26 11 0,000 0,07384913 0,11579809 ! synapsis GO:0007129 14 11 0,000 0,07384913 0,11572382 GO:0070192|chromosome organization involved in meiosis, ! Golgi vesicle budding GO:0048194 26 11 0,000 0,07384913 0,11564963 ! response to pain GO:0048265 27 11 0,000 0,07384913 0,11557555 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,07384913 0,11550155 ! blood vessel remodeling GO:0001974 30 11 0,000 0,07384913 0,11542766 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,07384913 0,11535385 ! bone resorption GO:0045453 16 11 0,000 0,07384913 0,11528015 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,07384913 0,11520653 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,07384913 0,11513301 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07384913 0,11505958 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07384913 0,11498625 ! melanocyte differentiation GO:0030318 20 11 0,000 0,07384913 0,11491301 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,07384913 0,11483987 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,07384913 0,11476681 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,07384913 0,11469385 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,07384913 0,11462098 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,07384913 0,11454821 ! UV protection GO:0009650 20 11 0,000 0,07384913 0,11447553 ! adult heart development GO:0007512 16 11 0,000 0,07384913 0,11440294 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07384913 0,11433044 ! macroautophagy GO:0016236 19 11 0,000 0,07384913 0,11425803 ! temperature homeostasis GO:0001659 18 11 0,000 0,07384913 0,11418571 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,07384913 0,11411349 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,07384913 0,11404136 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,07384913 0,11396932 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,07384913 0,11389737 ! regulation of organ growth GO:0046620 14 11 0,000 0,07384913 0,11382551 ! pigment granule localization GO:0051875 20 11 0,000 0,07384913 0,11375374 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,07384913 0,11368206 ! vasoconstriction GO:0042310 20 11 0,000 0,07384913 0,11361047 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,07384913 0,11353897 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,07384913 0,11346757 ! embryonic axis specification GO:0000578 19 11 0,000 0,07384913 0,11339625 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,07384913 0,11332502 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07384913 0,11325388 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,07384913 0,11318283 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,07384913 0,11311187 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,07384913 0,113041 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,07384913 0,11297021 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,07384913 0,11289952 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,07384913 0,11282891 ! prophase GO:0051324 17 11 0,000 0,07384913 0,11275839 ! neuroblast proliferation GO:0007405 25 11 0,000 0,07384913 0,11268796 ! nucleosome positioning GO:0016584 15 11 0,000 0,07384913 0,11261762 ! regulation of isotype switching GO:0045191 24 11 0,000 0,07384913 0,11254737 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,07384913 0,1124772 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,07384913 0,11240712 ! apical protein localization GO:0045176 18 11 0,000 0,07384913 0,11233713 ! acid secretion GO:0046717 20 11 0,000 0,07384913 0,11226722 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07384913 0,11219741 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,07384913 0,11212767 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,07384913 0,11205803 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,07384913 0,11198847 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,07384913 0,111919 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,07384913 0,11184961 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,07384913 0,11178032 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07384913 0,1117111 ! germ cell migration GO:0008354 26 11 0,000 0,07384913 0,11164197 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,07384913 0,11157293 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,07384913 0,11150397 ! activation of innate immune response GO:0002218 16 11 0,000 0,07384913 0,1114351 GO:0002758|innate immune response-activating signal transduction, ! cardiac cell differentiation GO:0035051 36 11 0,000 0,07384913 0,11136631 ! lysogeny GO:0030069 22 11 0,000 0,07384913 0,11129761 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07384913 0,11122899 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,07384913 0,11116046 ! regulation of embryonic development GO:0045995 35 11 0,000 0,07384913 0,11109201 ! nucleus localization GO:0051647 22 11 0,000 0,07384913 0,11102365 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,0752268 0,11302526 ! regulation of cytokine biosynthetic process GO:0042035 108 66 1,000 0,07723401 0,1159697 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,07723401 0,11589846 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,07925803 0,11886272 GO:0035113|embryonic appendage morphogenesis, ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,07925803 0,1187898 ! secondary metabolic process GO:0019748 125 67 1,000 0,07925803 0,11871697 ! myeloid cell differentiation GO:0030099 126 67 1,000 0,07925803 0,11864422 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,08028707 0,12011103 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,08028707 0,12003752 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,08028707 0,11996411 ! mating GO:0007618 17 12 0,000 0,08028707 0,11989078 ! hippocampus development GO:0021766 29 12 0,000 0,08028707 0,11981754 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,08028707 0,11974439 ! T cell proliferation GO:0042098 32 12 0,000 0,08028707 0,11967133 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08028707 0,11959836 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,08028707 0,11952548 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,08028707 0,11945269 ! drug transport GO:0015893 16 12 0,000 0,08028707 0,11937998 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,08028707 0,11930737 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,08028707 0,11923484 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,08028707 0,1191624 ! polyamine metabolic process GO:0006595 18 12 0,000 0,08028707 0,11909005 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,08028707 0,11901779 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,08028707 0,11894561 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,08028707 0,11887352 ! lipid digestion GO:0044241 21 12 0,000 0,08028707 0,11880152 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,08028707 0,11872961 ! entry into host cell GO:0030260 34 12 0,000 0,08028707 0,11865778 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08028707 0,11858604 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,08028707 0,11851439 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,08028707 0,11844282 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08028707 0,11837134 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,08028707 0,11829995 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,08028707 0,11822864 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,08028707 0,11815742 ! snRNA metabolic process GO:0016073 30 12 0,000 0,08028707 0,11808628 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,08028707 0,11801523 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,08028707 0,11794426 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08028707 0,11787338 ! fucose catabolic process GO:0019317 25 12 0,000 0,08028707 0,11780259 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,08028707 0,11773188 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,08028707 0,11766126 ! autonomic nervous system development GO:0048483 24 12 0,000 0,08028707 0,11759071 ! zymogen activation GO:0031638 18 12 0,000 0,08028707 0,11752026 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,08028707 0,11744989 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,08028707 0,1173796 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,08028707 0,1173094 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,08028707 0,11723928 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,08028707 0,11716924 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,08028707 0,11709929 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,08028707 0,11702942 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,08028707 0,11695964 ! defense response to fungus GO:0050832 15 12 0,000 0,08028707 0,11688994 ! developmental induction GO:0031128 22 12 0,000 0,08028707 0,11682032 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,08028707 0,11675078 ! lamellipodium assembly GO:0030032 24 12 0,000 0,08028707 0,11668133 ! response to cold GO:0009409 17 12 0,000 0,08028707 0,11661196 ! establishment of cell polarity GO:0030010 21 12 0,000 0,08028707 0,11654267 ! regulation of synapse organization GO:0050807 18 12 0,000 0,08028707 0,11647346 ! localization within membrane GO:0051668 26 12 0,000 0,08028707 0,11640434 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,08129853 0,11780089 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,08129853 0,11773106 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,08129853 0,11766132 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,08129853 0,11759166 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,08129853 0,11752207 ! viral reproduction GO:0016032 142 68 1,000 0,08129853 0,11745258 ! activation of immune response GO:0002253 120 70 1,000 0,08542766 0,12334502 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,08668044 0,12507992 ! cGMP metabolic process GO:0046068 18 13 0,000 0,08668044 0,12500608 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,08668044 0,12493233 ! regulation of chemokine production GO:0032642 18 13 0,000 0,08668044 0,12485867 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,08668044 0,1247851 ! peroxisomal transport GO:0043574 28 13 0,000 0,08668044 0,12471161 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,08668044 0,1246382 ! cartilage condensation GO:0001502 22 13 0,000 0,08668044 0,12456489 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,08668044 0,12449166 ! organelle fusion GO:0048284 36 13 0,000 0,08668044 0,12441851 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,08668044 0,12434545 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,08668044 0,12427248 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,08668044 0,12419959 ! endocrine pancreas development GO:0031018 25 13 0,000 0,08668044 0,12412679 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,08668044 0,12405408 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,08668044 0,12398144 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,08668044 0,1239089 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,08668044 0,12383644 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,08668044 0,12376406 ! methionine metabolic process GO:0006555 31 13 0,000 0,08668044 0,12369177 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,08668044 0,12361956 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,08668044 0,12354744 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,08668044 0,1234754 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,08668044 0,12340344 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,08668044 0,12333157 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,08668044 0,12325978 ! exocrine system development GO:0035272 34 13 0,000 0,08668044 0,12318808 ! asymmetric protein localization GO:0008105 24 13 0,000 0,08668044 0,12311646 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,08668044 0,12304492 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,08668044 0,12297346 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,08668044 0,12290209 ! protein homotetramerization GO:0051289 24 13 0,000 0,08668044 0,1228308 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,08668044 0,1227596 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,08668044 0,12268847 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,08668044 0,12261743 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,08668044 0,12254647 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,08668044 0,1224756 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,08668044 0,1224048 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,08668044 0,12233409 ! histone methylation GO:0016571 29 13 0,000 0,08668044 0,12226346 ! chromatin silencing GO:0006342 29 13 0,000 0,08668044 0,12219291 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,08668044 0,12212244 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,08668044 0,12205205 ! regulation of epidermis development GO:0045682 19 13 0,000 0,08668044 0,12198174 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,08668044 0,12191152 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,08668044 0,12184137 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,08668044 0,12177131 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,08668044 0,12170133 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,08668044 0,12163142 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,08668044 0,1215616 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,08668044 0,12149186 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,08668044 0,12142219 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,08668044 0,12135261 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,08668044 0,12128311 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,08668044 0,12121368 ! insulin secretion GO:0030073 24 13 0,000 0,08668044 0,12114434 ! acrosome reaction GO:0007340 19 13 0,000 0,08668044 0,12107508 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,08668044 0,12100589 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,08668044 0,12093678 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,08751566 0,12203239 ! appendage morphogenesis GO:0035107 150 72 1,000 0,08961886 0,12489382 GO:0035108|limb morphogenesis, ! B cell activation GO:0042113 179 72 1,000 0,08961886 0,12482261 ! appendage development GO:0048736 151 73 1,000 0,09173694 0,12769992 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 1,000 0,09173694 0,1276272 ! regulation of immune effector process GO:0002697 156 73 1,000 0,09173694 0,12755456 ! rRNA transcription GO:0009303 28 14 0,000 0,09302954 0,12927825 ! water transport GO:0006833 21 14 0,000 0,09302954 0,12920475 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,09302954 0,12913134 ! non-recombinational repair GO:0000726 29 14 0,000 0,09302954 0,12905801 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,09302954 0,12898477 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,09302954 0,12891161 ! RNA polyadenylation GO:0043631 32 14 0,000 0,09302954 0,12883853 ! palate development GO:0060021 32 14 0,000 0,09302954 0,12876553 ! regulated secretory pathway GO:0045055 24 14 0,000 0,09302954 0,12869262 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,09302954 0,12861979 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,09302954 0,12854704 ! arginine metabolic process GO:0006525 21 14 0,000 0,09302954 0,12847437 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,09302954 0,12840179 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,09302954 0,12832928 ! regulation of heart rate GO:0002027 25 14 0,000 0,09302954 0,12825686 ! organic alcohol transport GO:0015850 29 14 0,000 0,09302954 0,12818452 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,09302954 0,12811227 ! neutral amino acid transport GO:0015804 28 14 0,000 0,09302954 0,12804009 ! bone mineralization GO:0030282 18 14 0,000 0,09302954 0,127968 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,09302954 0,12789598 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,09302954 0,12782405 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,09302954 0,1277522 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,09302954 0,12768043 ! regulation of cellular pH GO:0030641 27 14 0,000 0,09302954 0,12760874 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,09302954 0,12753713 ! ribosome assembly GO:0042255 18 14 0,000 0,09302954 0,1274656 ! cerebellum development GO:0021549 23 14 0,000 0,09302954 0,12739415 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,09302954 0,12732278 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,09302954 0,12725149 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,09302954 0,12718028 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,09302954 0,12710915 ! NADP metabolic process GO:0006739 24 14 0,000 0,09302954 0,1270381 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,09302954 0,12696713 ! oxygen transport GO:0015671 22 14 0,000 0,09302954 0,12689624 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,09302954 0,12682543 ! male genitalia development GO:0030539 26 14 0,000 0,09302954 0,12675469 ! regulation of RNA stability GO:0043487 33 14 0,000 0,09302954 0,12668404 ! regulation of axon extension GO:0030516 43 14 0,000 0,09302954 0,12661346 ! amino acid transport GO:0006865 148 74 1,000 0,09386962 0,12768568 ! organelle localization GO:0051640 155 74 1,000 0,09386962 0,12761462 ! eye development GO:0001654 155 75 1,000 0,09601658 0,13046079 ! rhythmic process GO:0048511 142 75 1,000 0,09601658 0,13038827 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,09817752 0,13324871 ! learning or memory GO:0007611 161 76 1,000 0,09817752 0,13317472 ! lactation GO:0007595 30 15 0,000 0,09933468 0,1346696 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,09933468 0,13459491 ! reproductive cellular process GO:0048610 22 15 0,000 0,09933468 0,1345203 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,09933468 0,13444578 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,09933468 0,13437133 ! superoxide anion generation GO:0042554 22 15 0,000 0,09933468 0,13429697 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,09933468 0,13422269 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,09933468 0,13414849 ! copper ion transport GO:0006825 22 15 0,000 0,09933468 0,13407438 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,09933468 0,13400034 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,09933468 0,13392639 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,09933468 0,13385252 ! sulfate transport GO:0008272 27 15 0,000 0,09933468 0,13377873 ! response to cAMP GO:0051591 25 15 0,000 0,09933468 0,13370503 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,09933468 0,1336314 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,09933468 0,13355786 ! response to hexose stimulus GO:0009746 25 15 0,000 0,09933468 0,13348439 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,09933468 0,13341101 ! vesicle coating GO:0006901 38 15 0,000 0,09933468 0,13333771 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,09933468 0,13326448 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,09933468 0,13319134 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,09933468 0,13311828 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,09933468 0,1330453 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,09933468 0,1329724 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,09933468 0,13289958 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,09933468 0,13282683 ! histone deacetylation GO:0016575 24 15 0,000 0,09933468 0,13275417 ! water homeostasis GO:0030104 28 15 0,000 0,09933468 0,13268159 ! cofactor transport GO:0051181 30 15 0,000 0,09933468 0,13260908 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,09933468 0,13253666 ! muscle maintenance GO:0046716 26 15 0,000 0,09933468 0,13246431 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,09933468 0,13239205 ! intestinal absorption GO:0050892 31 15 0,000 0,09933468 0,13231986 ! dopamine metabolic process GO:0042417 35 15 0,000 0,09933468 0,13224775 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,09933468 0,13217572 ! heme biosynthetic process GO:0006783 33 15 0,000 0,09933468 0,13210377 ! cell killing GO:0001906 32 15 0,000 0,09933468 0,1320319 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,09933468 0,1319601 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,09933468 0,13188838 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,09933468 0,13181674 ! actin filament polymerization GO:0030041 27 15 0,000 0,09933468 0,13174518 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,09933468 0,1316737 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,10035214 0,13295026 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,10254016 0,1357754 ! blood coagulation GO:0007596 151 79 1,000 0,10474128 0,13861482 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,10474128 0,13853977 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,10474128 0,1384648 ! protein oligomerization GO:0051259 149 79 1,000 0,10474128 0,13838992 ! regulation of synaptic transmission GO:0050804 159 79 1,000 0,10474128 0,13831511 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,10559617 0,13936868 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,10559617 0,13929343 ! positive regulation of cell size GO:0045793 29 16 0,000 0,10559617 0,13921826 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,10559617 0,13914317 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,10559617 0,13906816 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,10559617 0,13899323 ! bone remodeling GO:0046849 28 16 0,000 0,10559617 0,13891838 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,10559617 0,13884361 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10559617 0,13876893 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,10559617 0,13869432 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,10559617 0,13861979 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,10559617 0,13854535 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,10559617 0,13847098 ! startle response GO:0001964 28 16 0,000 0,10559617 0,13839669 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,10559617 0,13832248 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,10559617 0,13824836 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,10559617 0,13817431 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,10559617 0,13810034 ! protein polyubiquitination GO:0000209 41 16 0,000 0,10559617 0,13802645 ! glutamate metabolic process GO:0006536 25 16 0,000 0,10559617 0,13795264 ! response to osmotic stress GO:0006970 27 16 0,000 0,10559617 0,13787891 ! lysosomal transport GO:0007041 31 16 0,000 0,10559617 0,13780525 ! fructose metabolic process GO:0006000 25 16 0,000 0,10559617 0,13773168 ! L-amino acid transport GO:0015807 33 16 0,000 0,10559617 0,13765818 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,10559617 0,13758476 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 36 16 0,000 0,10559617 0,13751143 ! negative regulation of immune response GO:0050777 38 16 0,000 0,10559617 0,13743816 ! axon cargo transport GO:0008088 46 16 0,000 0,10559617 0,13736498 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,10559617 0,13729188 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,10559617 0,13721885 ! DNA replication initiation GO:0006270 28 16 0,000 0,10559617 0,1371459 ! neuron recognition GO:0008038 40 16 0,000 0,10559617 0,13707303 ! mRNA splice site selection GO:0006376 44 16 0,000 0,10559617 0,13700023 ! tissue regeneration GO:0042246 27 16 0,000 0,10559617 0,13692751 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,10559617 0,13685487 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,10559617 0,13678231 ! biomineral formation GO:0031214 22 16 0,000 0,10559617 0,13670982 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,10559617 0,13663741 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,10559617 0,13656508 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,10559617 0,13649282 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,10559617 0,13642064 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,10559617 0,13634854 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,10559617 0,13627651 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,10559617 0,13620456 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,10559617 0,13613268 ! peptide hormone processing GO:0016486 27 16 0,000 0,10559617 0,13606088 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 1,000 0,10695523 0,13773939 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,10695523 0,13766682 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,10918171 0,14045861 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,1118143 0,14376965 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,1118143 0,14369402 ! filopodium assembly GO:0046847 42 17 0,000 0,1118143 0,14361847 ! gene silencing by RNA GO:0031047 38 17 0,000 0,1118143 0,143543 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,1118143 0,14346761 ! glial cell development GO:0021782 28 17 0,000 0,1118143 0,1433923 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,1118143 0,14331707 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,1118143 0,14324191 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,1118143 0,14316684 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,1118143 0,14309184 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,1118143 0,14301693 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,1118143 0,14294209 ! NAD metabolic process GO:0019674 33 17 0,000 0,1118143 0,14286733 ! membrane budding GO:0006900 42 17 0,000 0,1118143 0,14279264 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,1118143 0,14271804 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,1118143 0,14264351 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,1118143 0,14256906 ! genitalia development GO:0048806 32 17 0,000 0,1118143 0,14249469 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,1118143 0,1424204 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,1118143 0,14234618 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,1118143 0,14227205 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,1118143 0,14219798 ! steroid catabolic process GO:0006706 34 17 0,000 0,1118143 0,142124 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,1118143 0,14205009 ! gas transport GO:0015669 26 17 0,000 0,1118143 0,14197626 ! organic cation transport GO:0015695 32 17 0,000 0,1118143 0,14190251 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,1118143 0,14182883 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,11367116 0,14410931 ! inorganic anion transport GO:0015698 156 83 1,000 0,11367116 0,14403457 ! response to metal ion GO:0010038 158 84 1,000 0,11593358 0,14682517 ! regulation of ligase activity GO:0051340 147 84 1,000 0,11593358 0,14674909 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,11798937 0,14927397 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,11798937 0,14919671 ! limbic system development GO:0021761 40 18 0,000 0,11798937 0,14911952 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,11798937 0,14904242 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,11798937 0,14896539 ! adult walking behavior GO:0007628 36 18 0,000 0,11798937 0,14888845 ! patterning of blood vessels GO:0001569 43 18 0,000 0,11798937 0,14881158 ! heart looping GO:0001947 34 18 0,000 0,11798937 0,1487348 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,11798937 0,14865809 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,11798937 0,14858146 ! glycine metabolic process GO:0006544 30 18 0,000 0,11798937 0,14850491 ! glutamine metabolic process GO:0006541 29 18 0,000 0,11798937 0,14842844 ! response to retinoic acid GO:0032526 31 18 0,000 0,11798937 0,14835205 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,11798937 0,14827574 ! DNA integration GO:0015074 32 18 0,000 0,11798937 0,1481995 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,11798937 0,14812335 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,11798937 0,14804727 ! neural crest cell migration GO:0001755 41 18 0,000 0,11798937 0,14797127 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,11798937 0,14789535 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,11798937 0,1478195 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,11798937 0,14774374 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,11798937 0,14766805 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,11798937 0,14759244 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,11798937 0,14751691 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,11798937 0,14744145 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,11798937 0,14736607 ! detection of bacterium GO:0016045 22 18 0,000 0,11798937 0,14729077 ! microspike assembly GO:0030035 46 18 0,000 0,11798937 0,14721554 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,11798937 0,1471404 ! hemostasis GO:0007599 165 85 1,000 0,11820745 0,14733714 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,11820745 0,14726201 ! regulation of transmission of nerve impulse GO:0051969 167 85 1,000 0,11820745 0,14718695 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,12049248 0,14995575 ! regulation of lyase activity GO:0051339 169 86 1,000 0,12049248 0,1498794 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,12049248 0,14980312 GO:0002696|positive regulation of leukocyte activation, ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,12412169 0,15423666 ! positive regulation of translation GO:0045727 31 19 0,000 0,12412169 0,15415825 ! negative regulation of defense response GO:0031348 27 19 0,000 0,12412169 0,15407992 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,12412169 0,15400167 ! neuron maturation GO:0042551 46 19 0,000 0,12412169 0,15392349 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,12412169 0,1538454 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,12412169 0,15376738 GO:0019692|deoxyribose phosphate metabolic process, ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,12412169 0,15368945 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,12412169 0,15361159 ! memory GO:0007613 34 19 0,000 0,12412169 0,15353381 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,12412169 0,15345611 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,12412169 0,15337849 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,12412169 0,15330095 ! cerebral cortex development GO:0021987 40 19 0,000 0,12412169 0,15322349 ! response to vitamin A GO:0033189 32 19 0,000 0,12412169 0,1531461 ! heme metabolic process GO:0042168 40 19 0,000 0,12412169 0,15306879 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,12412169 0,15299156 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,12412169 0,15291441 ! response to fungus GO:0009620 26 19 0,000 0,12412169 0,15283734 ! peptide cross-linking GO:0018149 39 19 0,000 0,12412169 0,15276034 ! protein export from nucleus GO:0006611 40 19 0,000 0,12412169 0,15268342 ! heart process GO:0003015 32 19 0,000 0,12412169 0,15260658 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,12412169 0,15252982 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,12412169 0,15245313 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,12412169 0,15237652 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,12412169 0,15229999 ! vitamin transport GO:0051180 31 19 0,000 0,12412169 0,15222353 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,12412169 0,15214716 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,12412169 0,15207085 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,12412169 0,15199463 ! cilium assembly GO:0042384 38 19 0,000 0,12412169 0,15191848 ! peptide hormone secretion GO:0030072 32 19 0,000 0,12412169 0,1518424 ! cellular respiration GO:0045333 143 88 1,000 0,12509502 0,15295652 ! amine biosynthetic process GO:0009309 146 88 1,000 0,12509502 0,15288 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,12509502 0,15280356 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,127412 0,15555598 ! regulation of neurological system process GO:0031644 175 89 1,000 0,127412 0,15547828 ! response to inorganic substance GO:0010035 173 90 1,000 0,12973912 0,15823897 ! protein secretion GO:0009306 45 20 0,000 0,13021154 0,15873592 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,13021154 0,15865675 ! positive regulation of ossification GO:0045778 50 20 0,000 0,13021154 0,15857766 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,13021154 0,15849865 ! skin development GO:0043588 42 20 0,000 0,13021154 0,15841971 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,13021154 0,15834086 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,13021154 0,15826208 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,13021154 0,15818338 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,13021154 0,15810476 ! response to vitamin GO:0033273 36 20 0,000 0,13021154 0,15802622 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,13021154 0,15794776 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,13021154 0,15786937 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,13021154 0,15779106 ! bile acid metabolic process GO:0008206 34 20 0,000 0,13021154 0,15771283 ! retinoid metabolic process GO:0001523 34 20 0,000 0,13021154 0,15763468 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,13021154 0,1575566 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,13021154 0,15747861 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,13021154 0,15740069 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,13021154 0,15732284 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,13021154 0,15724507 ! peptide secretion GO:0002790 38 20 0,000 0,13021154 0,15716738 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,13021154 0,15708977 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,13021154 0,15701223 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,13021154 0,15693477 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,13021154 0,15685739 ! cell-cell junction organization GO:0045216 43 20 0,000 0,13021154 0,15678008 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,13021154 0,15670285 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,13021154 0,15662569 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,13021154 0,15654861 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,13021154 0,15647161 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,13021154 0,15639468 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,13021154 0,15631783 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,13021154 0,15624105 ! negative regulation of translation GO:0017148 32 20 0,000 0,13021154 0,15616435 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,13021154 0,15608773 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,13207612 0,1582452 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell killing GO:0031341 46 21 0,000 0,13625922 0,16317709 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,13625922 0,16309714 ! hormone secretion GO:0046879 39 21 0,000 0,13625922 0,16301727 ! lipid phosphorylation GO:0046834 43 21 0,000 0,13625922 0,16293748 ! cAMP metabolic process GO:0046058 41 21 0,000 0,13625922 0,16285776 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,13625922 0,16277812 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,13625922 0,16269857 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,13625922 0,16261908 ! smooth muscle contraction GO:0006939 48 21 0,000 0,13625922 0,16253968 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,13625922 0,16246035 ! plasma membrane fusion GO:0045026 33 21 0,000 0,13625922 0,1623811 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,13625922 0,16230193 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,13625922 0,16222284 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,13625922 0,16214382 ! collagen fibril organization GO:0030199 62 21 0,000 0,13625922 0,16206488 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,13625922 0,16198602 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,13625922 0,16190723 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,13625922 0,16182852 ! collagen catabolic process GO:0030574 29 21 0,000 0,13625922 0,16174989 ! sperm-egg recognition GO:0035036 23 21 0,000 0,13625922 0,16167133 ! actin filament-based movement GO:0030048 47 21 0,000 0,13625922 0,16159285 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,13625922 0,16151444 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,1367788 0,1620517 ! phospholipid biosynthetic process GO:0008654 188 95 1,000 0,14151807 0,16758539 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,14151807 0,16750419 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,14226501 0,16830675 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,14226501 0,16822528 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,14226501 0,16814389 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,14226501 0,16806259 ! microtubule-based transport GO:0010970 59 22 0,000 0,14226501 0,16798136 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,14226501 0,16790021 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,14226501 0,16781914 ! cellular response to starvation GO:0009267 37 22 0,000 0,14226501 0,16773814 ! vacuolar transport GO:0007034 41 22 0,000 0,14226501 0,16765723 ! central nervous system neuron development GO:0021954 47 22 0,000 0,14226501 0,16757639 ! fucose metabolic process GO:0006004 44 22 0,000 0,14226501 0,16749563 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,14226501 0,16741495 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,14226501 0,16733434 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,14226501 0,16725382 ! cytolysis GO:0019835 27 22 0,000 0,14226501 0,16717337 ! vasodilation GO:0042311 40 22 0,000 0,14226501 0,167093 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,14226501 0,1670127 ! G1 phase GO:0051318 44 22 0,000 0,14226501 0,16693248 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,14226501 0,16685234 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,14226501 0,16677228 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,14226501 0,16669229 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,14226501 0,16661238 ! sarcomere organization GO:0045214 32 22 0,000 0,14226501 0,16653255 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,14226501 0,16645279 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,14226501 0,16637311 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,14226501 0,16629351 ! response to protein stimulus GO:0051789 158 96 1,000 0,14390084 0,16812518 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,14822922 0,17309942 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,14822922 0,17301672 ! glycerol metabolic process GO:0006071 40 23 0,000 0,14822922 0,17293409 ! viral genome replication GO:0019079 44 23 0,000 0,14822922 0,17285154 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,14822922 0,17276908 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,14822922 0,17268669 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,14822922 0,17260438 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,14822922 0,17252215 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,14822922 0,17243999 ! peroxisome organization GO:0007031 43 23 0,000 0,14822922 0,17235792 ! lysosome organization GO:0007040 47 23 0,000 0,14822922 0,17227592 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,14822922 0,172194 ! vesicle targeting GO:0006903 49 23 0,000 0,14822922 0,17211216 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,14822922 0,1720304 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,14822922 0,17194871 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,14822922 0,1718671 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,14822922 0,17178557 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,14822922 0,17170412 ! DNA modification GO:0006304 36 23 0,000 0,14822922 0,17162274 ! fatty acid transport GO:0015908 47 23 0,000 0,14822922 0,17154144 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,14822922 0,17146022 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,14822922 0,17137908 ! hormone transport GO:0009914 41 23 0,000 0,14822922 0,17129801 ! cell-cell recognition GO:0009988 28 23 0,000 0,14822922 0,17121701 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,14822922 0,1711361 ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,14822922 0,17105526 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,14869146 0,17150767 ! positive regulation of immune response GO:0050778 175 100 1,000 0,15351401 0,17698666 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,15415212 0,17763851 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,15415212 0,17755475 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,15415212 0,17747108 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,15415212 0,17738749 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,15415212 0,17730397 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,15415212 0,17722053 ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,15415212 0,17713718 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,15415212 0,1770539 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,15415212 0,17697069 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,15415212 0,17688757 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,15415212 0,17680452 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,15415212 0,17672156 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,15415212 0,17663867 ! pallium development GO:0021543 56 24 0,000 0,15415212 0,17655585 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,15415212 0,17647312 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,15415212 0,17639046 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,15415212 0,17630788 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,15415212 0,17622538 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,15415212 0,17614295 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,15415212 0,17606061 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,15415212 0,17597833 ! regulation of amine transport GO:0051952 41 24 0,000 0,15415212 0,17589614 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,160034 0,18252244 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,160034 0,18243727 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,160034 0,18235218 ! phototransduction GO:0007602 37 25 0,000 0,160034 0,18226717 ! keratinization GO:0031424 37 25 0,000 0,160034 0,18218223 ! vacuole organization GO:0007033 49 25 0,000 0,160034 0,18209738 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,160034 0,1820126 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,160034 0,18192791 ! immunoglobulin production GO:0002377 62 25 0,000 0,160034 0,18184329 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,160034 0,18175875 ! protein tetramerization GO:0051262 57 25 0,000 0,160034 0,18167429 ! initiation of viral infection GO:0019059 60 26 0,000 0,16587515 0,18821783 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,16587515 0,18813045 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,16587515 0,18804315 GO:0006479|protein amino acid methylation, ! digestive system process GO:0022600 49 26 0,000 0,16587515 0,18795593 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,16587515 0,18786879 ! osteoblast differentiation GO:0001649 63 26 0,000 0,16587515 0,18778174 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,16587515 0,18769476 ! neural crest cell development GO:0014032 59 26 0,000 0,16587515 0,18760786 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 0,000 0,16587515 0,18752105 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,16587515 0,18743431 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,16587515 0,18734766 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,16587515 0,18726108 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,16587515 0,18717459 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,16587515 0,18708817 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,16587515 0,18700184 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,16587515 0,18691558 ! telomere organization GO:0032200 46 26 0,000 0,16587515 0,18682941 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,16587515 0,18674331 ! alditol metabolic process GO:0019400 44 26 0,000 0,16587515 0,18665729 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,16587515 0,18657136 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,17167584 0,19300693 ! embryonic pattern specification GO:0009880 49 27 0,000 0,17167584 0,19291815 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,17167584 0,19282946 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,17167584 0,19274084 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,17167584 0,1926523 ! iron ion transport GO:0006826 65 27 0,000 0,17167584 0,19256385 ! superoxide metabolic process GO:0006801 41 27 0,000 0,17167584 0,19247548 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,17167584 0,19238719 ! response to starvation GO:0042594 47 27 0,000 0,17167584 0,19229898 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,17167584 0,19221085 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,17167584 0,1921228 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,17167584 0,19203483 ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,17743635 0,19838764 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,17743635 0,19829689 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,17743635 0,19820622 ! vesicle docking GO:0048278 55 28 0,000 0,17743635 0,19811563 ! circadian rhythm GO:0007623 56 28 0,000 0,17743635 0,19802512 ! dendrite development GO:0016358 67 28 0,000 0,17743635 0,1979347 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,17743635 0,19784436 ! sperm motility GO:0030317 37 28 0,000 0,17743635 0,1977541 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,17743635 0,19766393 ! base-excision repair GO:0006284 41 28 0,000 0,17743635 0,19757384 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,17743635 0,19748382 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,17743635 0,1973939 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,17743635 0,19730405 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,17743635 0,19721428 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,17743635 0,1971246 ! glutathione metabolic process GO:0006749 42 28 0,000 0,17743635 0,197035 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,17743635 0,19694548 ! lipid oxidation GO:0034440 48 28 0,000 0,17743635 0,19685604 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,17743635 0,19676668 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,18315696 0,20301835 ! translational initiation GO:0006413 66 29 0,000 0,18315696 0,20292628 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,18315696 0,20283429 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,18315696 0,20274239 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,18315696 0,20265057 ! autophagy GO:0006914 47 29 0,000 0,18315696 0,20255883 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,18315696 0,20246717 ! somitogenesis GO:0001756 52 29 0,000 0,18315696 0,2023756 ! synaptogenesis GO:0007416 46 29 0,000 0,18315696 0,20228411 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,18315696 0,2021927 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,18315696 0,20210138 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,18883794 0,20827589 ! phenol metabolic process GO:0018958 56 30 0,000 0,18883794 0,2081819 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,18883794 0,208088 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,18883794 0,20799418 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,18883794 0,20790045 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,18883794 0,2078068 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,18883794 0,20771324 ! acute-phase response GO:0006953 50 30 0,000 0,18883794 0,20761976 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,18883794 0,20752636 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,18883794 0,20743305 ! myofibril assembly GO:0030239 50 30 0,000 0,18883794 0,20733982 GO:0055002|striated muscle cell development, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,18883794 0,20724667 ! phospholipid transport GO:0015914 65 30 0,000 0,18883794 0,20715361 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,18883794 0,20706064 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,18883794 0,20696774 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,18883794 0,20687493 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,19447958 0,21295993 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,19447958 0,21286452 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,19447958 0,2127692 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,19447958 0,21267395 ! regulation of innate immune response GO:0045088 57 31 0,000 0,19447958 0,2125788 ! peptide transport GO:0015833 60 31 0,000 0,19447958 0,21248373 ! detection of light stimulus GO:0009583 44 31 0,000 0,19447958 0,21238874 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,19447958 0,21229384 ! natural killer cell activation GO:0030101 50 31 0,000 0,19447958 0,21219902 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,19447958 0,21210429 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,20008213 0,2181172 ! collagen metabolic process GO:0032963 49 32 0,000 0,20008213 0,21801992 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,20008213 0,21792272 ! muscle cell development GO:0055001 52 32 0,000 0,20008213 0,2178256 ! mesoderm formation GO:0001707 73 32 0,000 0,20008213 0,21772858 ! BMP signaling pathway GO:0030509 71 32 0,000 0,20008213 0,21763164 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,20008213 0,21753478 ! gene silencing GO:0016458 71 32 0,000 0,20008213 0,21743801 ! regulation of pH GO:0006885 56 33 0,000 0,20564588 0,22338501 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,20564588 0,22328573 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,20564588 0,22318653 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,20564588 0,22308743 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,20564588 0,22298841 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,20564588 0,22288948 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,20564588 0,22279064 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,20564588 0,22269188 ! glial cell differentiation GO:0010001 67 34 0,000 0,21117108 0,22857375 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,21117108 0,22847252 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,21117108 0,22837138 ! spliceosome assembly GO:0000245 75 34 0,000 0,21117108 0,22827033 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,21117108 0,22816937 ! formation of primary germ layer GO:0001704 76 34 0,000 0,21117108 0,2280685 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,21117108 0,22796772 ! adult locomotory behavior GO:0008344 62 34 0,000 0,21117108 0,22786703 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,21665801 0,23368455 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,21665801 0,23358143 ! membrane docking GO:0022406 69 35 0,000 0,21665801 0,23347839 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,21665801 0,23337545 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,21665801 0,23327259 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,21665801 0,23316983 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,21665801 0,23306716 ! ceramide metabolic process GO:0006672 72 35 0,000 0,21665801 0,23296457 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,21665801 0,23286208 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,21665801 0,23275968 ! vesicle localization GO:0051648 70 35 0,000 0,21665801 0,23265737 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,22210692 0,23840387 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,22210692 0,23829917 ! protein targeting to membrane GO:0006612 75 36 0,000 0,22210692 0,23819456 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,22210692 0,23809004 ! cytokine production GO:0001816 68 36 0,000 0,22210692 0,23798562 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,22210692 0,23788128 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,22751809 0,24356997 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,22751809 0,24346329 ! actomyosin structure organization GO:0031032 68 37 0,000 0,22751809 0,24335669 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,22751809 0,24325019 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,23289176 0,24888651 ! organic anion transport GO:0015711 82 38 0,000 0,23289176 0,24877769 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,23289176 0,24866895 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,23289176 0,24856032 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,2382282 0,25414476 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,2382282 0,25403383 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,2382282 0,25392299 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,2382282 0,25381225 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,2382282 0,25370161 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,2382282 0,25359107 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,24352767 0,25911938 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,24352767 0,25900657 ! mismatch repair GO:0006298 58 40 0,000 0,24352767 0,25889386 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,24352767 0,25878125 ! RNA export from nucleus GO:0006405 61 41 0,000 0,24879042 0,26425869 ! mRNA catabolic process GO:0006402 79 41 0,000 0,24879042 0,26414385 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,24879042 0,2640291 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,24879042 0,26391446 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,24879042 0,26379991 ! gliogenesis GO:0042063 91 41 0,000 0,24879042 0,26368546 ! feeding behavior GO:0007631 69 41 0,000 0,24879042 0,26357112 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,24879042 0,26345687 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,24879042 0,26334272 GO:0015986|ATP synthesis coupled proton transport, ! RNA modification GO:0009451 64 41 0,000 0,24879042 0,26322867 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,2540167 0,26864191 ! regulation of protein secretion GO:0050708 77 42 0,000 0,2540167 0,26852566 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,2540167 0,26840952 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,25920677 0,27377525 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 0,000 0,25920677 0,27365694 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,25920677 0,27353873 ! regulation of tube size GO:0035150 76 43 0,000 0,25920677 0,27342062 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,25920677 0,27330261 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,25920677 0,27318471 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,25920677 0,2730669 ! segmentation GO:0035282 78 43 0,000 0,25920677 0,2729492 ! ion transmembrane transport GO:0034220 79 43 0,000 0,25920677 0,2728316 ! neuron migration GO:0001764 85 43 0,000 0,25920677 0,2727141 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,25920677 0,27259671 ! striated muscle contraction GO:0006941 85 44 0,000 0,26436088 0,27789743 ! phagocytosis GO:0006909 105 44 0,000 0,26436088 0,27777791 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,26436088 0,27765848 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,26947927 0,2829127 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,26947927 0,28279118 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,26947927 0,28266976 ! biopolymer methylation GO:0043414 91 45 0,000 0,26947927 0,28254844 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,26947927 0,28242722 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,26947927 0,28230611 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,27456219 0,28750769 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,27456219 0,28738451 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,2846226 0,29778716 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,2846226 0,29765968 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,2846226 0,29753232 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,2846226 0,29740506 ! response to calcium ion GO:0051592 94 49 0,000 0,28960058 0,30247722 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,28960058 0,30234796 ! regulation of ion transport GO:0043269 86 50 0,000 0,29454406 0,30737767 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,29454406 0,30724642 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,29454406 0,30711529 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,29454406 0,30698427 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,29454406 0,30685336 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,29454406 0,30672256 ! viral infectious cycle GO:0019058 104 51 0,000 0,29945327 0,31170189 ! peptide metabolic process GO:0006518 80 51 0,000 0,29945327 0,31156914 ! positive regulation of binding GO:0051099 88 52 0,000 0,30432846 0,31650678 ! excretion GO:0007588 87 52 0,000 0,30432846 0,31637209 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,30432846 0,31623752 ! amino acid activation GO:0043038 98 52 0,000 0,30432846 0,31610307 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,30916985 0,32099531 ! chromatin remodeling GO:0006338 122 53 0,000 0,30916985 0,32085894 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,30916985 0,3207227 ! regulation of translational initiation GO:0006446 87 54 0,000 0,31397769 0,32557195 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,31397769 0,32543382 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,31397769 0,3252958 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,31397769 0,32515791 ! membrane fusion GO:0006944 122 54 0,000 0,31397769 0,32502013 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,31397769 0,32488247 ! RNA catabolic process GO:0006401 103 55 0,000 0,31875221 0,32968317 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,31875221 0,32954365 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,31875221 0,32940425 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,31875221 0,32926497 ! cell recognition GO:0008037 98 55 0,000 0,31875221 0,3291258 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,32820218 0,33874014 ! regulation of actin filament length GO:0030832 118 58 0,000 0,33287809 0,3434211 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,33287809 0,34327614 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,33287809 0,3431313 ! gastrulation GO:0007369 122 58 0,000 0,33287809 0,34298658 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,33287809 0,34284198 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,33287809 0,3426975 ! nuclear export GO:0051168 110 59 0,000 0,33752159 0,34733161 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,34213289 0,3519287 ! regulation of endocytosis GO:0030100 104 60 0,000 0,34213289 0,35178058 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,34213289 0,35163258 ! adult behavior GO:0030534 104 60 0,000 0,34213289 0,35148472 ! regulation of cellular component size GO:0032535 125 61 0,000 0,34671223 0,3560395 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,34671223 0,3558899 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,34671223 0,35574043 ! proton transport GO:0015992 117 61 0,000 0,34671223 0,35559109 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,35125982 0,36010396 ! tRNA processing GO:0008033 102 62 0,000 0,35125982 0,35995291 ! mesoderm development GO:0007498 128 63 0,000 0,35577588 0,36442787 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,35577588 0,36427513 ! hydrogen transport GO:0006818 121 64 0,000 0,36026062 0,36871249 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,36026062 0,36855808 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,36471428 0,37295813 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,36471428 0,37280208 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,36471428 0,37264616 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,37352916 0,3814932 ! extracellular matrix organization GO:0030198 146 68 0,000 0,37789081 0,38578656 ! regulation of lipase activity GO:0060191 137 68 0,000 0,37789081 0,38562542 ! adaptive immune response GO:0002250 126 68 0,000 0,37789081 0,3854644 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,37789081 0,38530352 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,38222221 0,38955731 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,38222221 0,38939486 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,38222221 0,38923254 ! single fertilization GO:0007338 83 69 0,000 0,38222221 0,38907036 ! cell redox homeostasis GO:0045454 114 70 0,000 0,38652358 0,39328493 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,39079513 0,39746565 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,39503705 0,40161278 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,39503705 0,40144572 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,39503705 0,4012788 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,39503705 0,40111201 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,39924955 0,40522087 ! acute inflammatory response GO:0002526 118 74 0,000 0,40343283 0,40929668 ! transition metal ion transport GO:0000041 143 75 0,000 0,40758711 0,41333969 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,40758711 0,41316818 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,41171257 0,41717702 ! regulation of blood pressure GO:0008217 134 76 0,000 0,41171257 0,41700407 ! amine catabolic process GO:0009310 136 77 0,000 0,41580942 0,42097903 ! neurotransmitter transport GO:0006836 142 77 0,000 0,41580942 0,42080464 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,41580942 0,4206304 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,41580942 0,42045629 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,41987785 0,42439453 ! antigen processing and presentation GO:0019882 117 78 0,000 0,41987785 0,42421902 ! fertilization GO:0009566 99 78 0,000 0,41987785 0,42404365 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,42391806 0,42794703 ! exocytosis GO:0006887 153 83 0,000 0,43980059 0,44379713 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,43980059 0,44361389 ! digestion GO:0007586 130 84 0,000 0,44370261 0,44736503 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,44757755 0,45108579 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,45524697 0,45862612 ! nucleosome assembly GO:0006334 126 87 0,000 0,45524697 0,45843708 ! sensory perception of smell GO:0007608 117 88 0,000 0,45904182 0,46206805 ! chromatin assembly GO:0031497 128 88 0,000 0,45904182 0,46187775 ! cellular defense response GO:0006968 123 89 0,000 0,46281034 0,46547784 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,46655271 0,46904868 ! response to unfolded protein GO:0006986 139 90 0,000 0,46655271 0,46885573 ! ossification GO:0001503 205 91 0,000 0,47026912 0,47239616 ! defense response to bacterium GO:0042742 112 91 0,000 0,47026912 0,472202 ! bone development GO:0060348 206 92 0,000 0,47395974 0,47571226 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,47395974 0,4755169 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,47762475 0,47899724 GO:0010498|proteasomal protein catabolic process, ! vitamin metabolic process GO:0006766 153 93 0,000 0,47762475 0,47880068 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,48126433 0,48225134 ! sterol metabolic process GO:0016125 166 94 0,000 0,48126433 0,48205361 ! nucleosome organization GO:0034728 143 95 0,000 0,48487865 0,48547481 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,48487865 0,48527593 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,48487865 0,48507721 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,49203222 0,49203222