pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6558-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of MAP kinase activity GO:0043406 121 85 9,000 1,621E-10 3,728E-07 ! organ growth GO:0035265 11 7 4,000 2,05E-10 2,358E-07 ! carbohydrate homeostasis GO:0033500 39 33 6,000 1,365E-09 1,046E-06 GO:0042593|glucose homeostasis, ! activation of MAPK activity GO:0000187 84 59 7,000 3,724E-09 2,141E-06 ! cell cycle checkpoint GO:0000075 108 64 7,000 7,239E-09 3,33E-06 ! negative regulation of peptide secretion GO:0002792 6 5 3,000 7,943E-09 3,045E-06 GO:0046676|negative regulation of insulin secretion, ! negative regulation of transport GO:0051051 116 73 7,000 2,096E-08 6,888E-06 ! cellular response to hormone stimulus GO:0032870 109 74 7,000 2,338E-08 6,721E-06 ! regulation of protein export from nucleus GO:0046825 6 6 3,000 2,371E-08 6,059E-06 ! regulation of multicellular organism growth GO:0040014 65 50 6,000 2,917E-08 6,71E-06 ! DNA damage checkpoint GO:0000077 53 31 5,000 3,904E-08 8,162E-06 ! regulation of growth hormone secretion GO:0060123 11 7 3,000 5,505E-08 1,055E-05 ! positive regulation of hormone secretion GO:0046887 24 17 4,000 5,741E-08 1,016E-05 ! DNA integrity checkpoint GO:0031570 57 34 5,000 7,02E-08 1,153E-05 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 7,443E-08 1,141E-05 ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 7,724E-08 1,11E-05 ! negative regulation of kinase activity GO:0033673 100 58 6,000 8,42E-08 1,139E-05 ! interphase GO:0051325 159 88 7,000 9,258E-08 1,183E-05 ! induction of positive chemotaxis GO:0050930 14 8 3,000 1,096E-07 1,326E-05 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 1,096E-07 1,26E-05 ! negative regulation of transferase activity GO:0051348 105 61 6,000 1,203E-07 1,317E-05 ! regulation of response to external stimulus GO:0032101 139 96 7,000 1,831E-07 1,914E-05 ! regulation of insulin secretion GO:0050796 26 21 4,000 1,85E-07 1,85E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 1,942E-07 1,861E-05 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 3,037E-07 2,794E-05 ! regulation of peptide secretion GO:0002791 34 25 4,000 4,732E-07 4,186E-05 ! negative regulation of growth GO:0045926 123 75 6,000 5,083E-07 4,33E-05 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 5,089E-07 4,18E-05 GO:0050927|positive regulation of positive chemotaxis, ! negative regulation of secretion GO:0051048 49 31 4,000 1,468E-06 1,164E-04 ! DNA damage response, signal transduction GO:0042770 96 56 5,000 1,512E-06 1,159E-04 ! negative regulation of bone remodeling GO:0046851 26 14 3,000 1,521E-06 1,128E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 1,521E-06 1,093E-04 ! response to peptide hormone stimulus GO:0043434 84 57 5,000 1,681E-06 1,171E-04 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 2,064E-06 1,396E-04 ! negative regulation of tissue remodeling GO:0034104 27 15 3,000 2,064E-06 1,356E-04 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 2,367E-06 1,512E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 2,536E-06 1,576E-04 ! negative regulation of cell growth GO:0030308 106 62 5,000 2,774E-06 1,679E-04 ! regulation of hormone secretion GO:0046883 48 36 4,000 3,174E-06 1,872E-04 ! negative regulation of cell size GO:0045792 108 64 5,000 3,348E-06 1,925E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 4,558E-06 2,557E-04 ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 5,429E-06 2,973E-04 ! positive regulation of locomotion GO:0040017 35 20 3,000 7,146E-06 3,822E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 3,000 7,146E-06 3,735E-04 ! response to insulin stimulus GO:0032868 63 43 4,000 7,821E-06 3,997E-04 ! regulation of inflammatory response GO:0050727 60 44 4,000 8,779E-06 4,389E-04 ! regulation of chemotaxis GO:0050920 36 21 3,000 8,784E-06 4,298E-04 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 8,794E-06 4,214E-04 ! fibrinolysis GO:0042730 9 7 2,000 8,794E-06 4,128E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 8,794E-06 4,045E-04 ! B cell lineage commitment GO:0002326 17 7 2,000 8,794E-06 3,966E-04 ! T cell lineage commitment GO:0002360 12 7 2,000 8,794E-06 3,889E-04 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 1,068E-05 4,636E-04 ! regulation of behavior GO:0050795 38 22 3,000 1,068E-05 4,55E-04 ! response to UV GO:0009411 75 46 4,000 1,097E-05 4,587E-04 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 1,287E-05 5,285E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 1,4E-05 5,651E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,4E-05 5,553E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 1,537E-05 5,99E-04 ! fat cell differentiation GO:0045444 37 24 3,000 1,537E-05 5,89E-04 ! positive regulation of growth GO:0045927 67 50 4,000 1,661E-05 6,263E-04 ! regulation of protein localization GO:0032880 132 85 5,000 1,752E-05 6,498E-04 ! negative regulation of multicellular organismal process GO:0051241 133 85 5,000 1,752E-05 6,395E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 1,82E-05 6,541E-04 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of secretion GO:0051047 71 51 4,000 1,832E-05 6,484E-04 ! positive regulation of cell migration GO:0030335 92 51 4,000 1,832E-05 6,386E-04 ! cell cycle arrest GO:0007050 150 86 5,000 1,873E-05 6,43E-04 ! regulation of developmental growth GO:0048638 13 9 2,000 2,091E-05 7,072E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 2,091E-05 6,969E-04 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 3,000 2,141E-05 7,033E-04 ! regulation of bone remodeling GO:0046850 90 53 4,000 2,216E-05 7,178E-04 ! regulation of tissue remodeling GO:0034103 91 54 4,000 2,43E-05 7,761E-04 ! triglyceride metabolic process GO:0006641 34 28 3,000 2,903E-05 9,146E-04 ! positive regulation of cell motion GO:0051272 99 56 4,000 2,905E-05 9,028E-04 ! negative regulation of ossification GO:0030279 19 10 2,000 2,973E-05 9,117E-04 ! multicellular organism reproduction GO:0032504 83 57 4,000 3,168E-05 9,587E-04 GO:0048609|reproductive process in a multicellular organism, ! focal adhesion formation GO:0048041 24 11 2,000 4,069E-05 1,215E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 4,069E-05 1,2E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 4,069E-05 1,185E-03 GO:0010829|negative regulation of glucose transport, ! regulation of homeostatic process GO:0032844 105 60 4,000 4,07E-05 1,17E-03 ! regulation of striated muscle tissue development GO:0016202 47 31 3,000 4,395E-05 1,248E-03 ! regulation of muscle development GO:0048634 48 32 3,000 4,998E-05 1,402E-03 ! neutral lipid metabolic process GO:0006638 41 32 3,000 4,998E-05 1,385E-03 GO:0006639|acylglycerol metabolic process, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 5,158E-05 1,412E-03 ! response to gamma radiation GO:0010332 20 12 2,000 5,399E-05 1,461E-03 ! glycerol ether metabolic process GO:0006662 44 34 3,000 6,383E-05 1,707E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 6,987E-05 1,847E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 7,171E-05 1,874E-03 ! organic ether metabolic process GO:0018904 46 36 3,000 8,028E-05 2,075E-03 ! hormone-mediated signaling GO:0009755 49 36 3,000 8,028E-05 2,052E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 8,571E-05 2,166E-03 ! regulation of skeletal muscle tissue development GO:0048641 22 14 2,000 8,851E-05 2,213E-03 ! activation of MAPKK activity GO:0000186 21 14 2,000 8,851E-05 2,189E-03 ! negative regulation of blood coagulation GO:0030195 19 14 2,000 8,851E-05 2,166E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 9,809E-05 2,375E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 4,000 9,809E-05 2,35E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,101E-04 2,611E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,105E-04 2,592E-03 ! response to oxygen levels GO:0070482 137 74 4,000 1,118E-04 2,597E-03 ! regulation of protein transport GO:0051223 114 76 4,000 1,269E-04 2,919E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of protein binding GO:0043393 27 16 2,000 1,349E-04 3,072E-03 ! G1 phase GO:0051318 27 16 2,000 1,349E-04 3,042E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,349E-04 3,012E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 1,481E-04 3,275E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 1,63E-04 3,571E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 1,63E-04 3,538E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1,63E-04 3,505E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 1,63E-04 3,472E-03 ! negative regulation of coagulation GO:0050819 23 17 2,000 1,63E-04 3,44E-03 ! positive regulation of cell cycle GO:0045787 77 45 3,000 1,943E-04 4,062E-03 ! positive regulation of defense response GO:0031349 59 45 3,000 1,943E-04 4,025E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 1,943E-04 3,989E-03 ! pancreas development GO:0031016 26 18 2,000 1,947E-04 3,964E-03 ! regulation of glucose import GO:0046324 21 18 2,000 1,947E-04 3,929E-03 GO:0010827|regulation of glucose transport, ! regulation of defense response GO:0031347 117 84 4,000 2,036E-04 4,073E-03 ! regulation of ossification GO:0030278 71 46 3,000 2,117E-04 4,198E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 2,302E-04 4,525E-03 ! response to alkaloid GO:0043279 32 19 2,000 2,302E-04 4,486E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 2,302E-04 4,449E-03 ! regulation of muscle contraction GO:0006937 69 48 3,000 2,5E-04 4,791E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 2,695E-04 5,123E-03 ! regulation of intracellular transport GO:0032386 78 49 3,000 2,708E-04 5,106E-03 ! cell fate commitment GO:0045165 141 92 4,000 3,115E-04 5,824E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 3,13E-04 5,805E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 3,13E-04 5,759E-03 ! cell aging GO:0007569 32 21 2,000 3,13E-04 5,713E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 3,13E-04 5,668E-03 ! response to glucocorticoid stimulus GO:0051384 33 21 2,000 3,13E-04 5,624E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 3,163E-04 5,64E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 3,607E-04 6,382E-03 GO:0010810|regulation of cell-substrate adhesion, ! regulation of blood coagulation GO:0030193 34 22 2,000 3,607E-04 6,333E-03 ! protein tetramerization GO:0051262 39 22 2,000 3,607E-04 6,285E-03 ! response to light stimulus GO:0009416 153 96 4,000 3,794E-04 6,561E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 4,017E-04 6,895E-03 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 1,000 4,017E-04 6,844E-03 ! adaptation of signaling pathway GO:0022401 7 5 1,000 4,017E-04 6,794E-03 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 1,000 4,017E-04 6,744E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 4,017E-04 6,695E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 4,017E-04 6,647E-03 ! microvillus organization GO:0032528 7 5 1,000 4,017E-04 6,599E-03 GO:0030033|microvillus assembly, ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 4,017E-04 6,553E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 4,017E-04 6,507E-03 ! monocyte differentiation GO:0030224 8 5 1,000 4,017E-04 6,461E-03 ! negative regulation of multicellular organism growth GO:0040015 7 5 1,000 4,017E-04 6,416E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 4,017E-04 6,372E-03 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 4,017E-04 6,328E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 4,017E-04 6,285E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 4,017E-04 6,243E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 4,017E-04 6,201E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 4,017E-04 6,159E-03 ! negative regulation of smooth muscle contraction GO:0045986 9 5 1,000 4,017E-04 6,119E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 4,017E-04 6,078E-03 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 1,000 4,017E-04 6,039E-03 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 4,129E-04 6,167E-03 ! myelination GO:0042552 35 23 2,000 4,129E-04 6,127E-03 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 4,129E-04 6,088E-03 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 4,536E-04 6,646E-03 ! mitochondrial membrane organization GO:0007006 39 24 2,000 4,697E-04 6,837E-03 ! response to toxin GO:0009636 38 24 2,000 4,697E-04 6,794E-03 ! regulation of chromosome organization GO:0033044 35 25 2,000 5,312E-04 7,637E-03 ! positive regulation of nuclear division GO:0051785 39 25 2,000 5,312E-04 7,589E-03 GO:0045840|positive regulation of mitosis, ! regulation of heart contraction GO:0008016 91 60 3,000 5,906E-04 8,384E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 5,978E-04 8,435E-03 ! regulation of coagulation GO:0050818 39 26 2,000 5,978E-04 8,383E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 6E-04 8,364E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 6E-04 8,314E-03 ! mRNA stabilization GO:0048255 15 6 1,000 6E-04 8,264E-03 GO:0043489|RNA stabilization, ! activation of MAPKKK activity GO:0000185 10 6 1,000 6E-04 8,215E-03 ! pigment granule organization GO:0048753 11 6 1,000 6E-04 8,166E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 6E-04 8,118E-03 ! hyperosmotic response GO:0006972 8 6 1,000 6E-04 8,071E-03 ! ER overload response GO:0006983 7 6 1,000 6E-04 8,024E-03 ! response to dietary excess GO:0002021 7 6 1,000 6E-04 7,977E-03 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 6E-04 7,932E-03 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 1,000 6E-04 7,886E-03 ! male sex determination GO:0030238 9 6 1,000 6E-04 7,841E-03 ! astrocyte development GO:0014002 14 6 1,000 6E-04 7,797E-03 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 6E-04 7,753E-03 ! Schwann cell development GO:0014044 14 6 1,000 6E-04 7,71E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 6E-04 7,667E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 6E-04 7,625E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 6E-04 7,583E-03 ! meiosis GO:0007126 96 61 3,000 6,289E-04 7,904E-03 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 97 62 3,000 6,69E-04 8,362E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 6,693E-04 8,322E-03 ! cell junction assembly GO:0034329 56 28 2,000 7,462E-04 9,227E-03 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 7,462E-04 9,178E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 7,462E-04 9,129E-03 ! ensheathment of neurons GO:0007272 43 28 2,000 7,462E-04 9,081E-03 GO:0008366|axon ensheathment, ! placenta development GO:0001890 37 28 2,000 7,462E-04 9,033E-03 ! protein oligomerization GO:0051259 100 65 3,000 8,001E-04 9,634E-03 ! tissue homeostasis GO:0001894 42 29 2,000 8,284E-04 9,924E-03 GO:0048871|multicellular organismal homeostasis, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 8,365E-04 9,969E-03 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 8,365E-04 9,918E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 8,365E-04 9,867E-03 ! lipoprotein transport GO:0042953 9 7 1,000 8,365E-04 9,816E-03 ! cerebral cortex cell migration GO:0021795 11 7 1,000 8,365E-04 9,767E-03 ! T-helper 1 type immune response GO:0042088 11 7 1,000 8,365E-04 9,717E-03 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 8,365E-04 9,668E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of pigmentation during development GO:0048070 15 7 1,000 8,365E-04 9,62E-03 ! behavioral fear response GO:0001662 13 7 1,000 8,365E-04 9,572E-03 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 1,000 8,365E-04 9,525E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 8,365E-04 9,478E-03 ! response to UV-B GO:0010224 11 7 1,000 8,365E-04 9,431E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 8,365E-04 9,385E-03 ! regulation of fat cell differentiation GO:0045598 9 7 1,000 8,365E-04 9,34E-03 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 1,000 8,365E-04 9,295E-03 ! response to tumor cell GO:0002347 12 7 1,000 8,365E-04 9,25E-03 ! peptidyl-threonine modification GO:0018210 18 7 1,000 8,365E-04 9,206E-03 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 8,365E-04 9,162E-03 ! endosome to lysosome transport GO:0008333 10 7 1,000 8,365E-04 9,119E-03 ! negative regulation of calcium ion transport GO:0051926 9 7 1,000 8,365E-04 9,076E-03 ! cell-substrate adhesion GO:0031589 121 66 3,000 8,475E-04 9,152E-03 ! activation of protein kinase activity GO:0032147 102 69 3,000 1,002E-03 0,01076644 ! response to drug GO:0042493 108 69 3,000 1,002E-03 0,01071637 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,01E-03 0,01075079 GO:0060326|cell chemotaxis, ! meiosis I GO:0007127 52 32 2,000 1,109E-03 0,01175347 ! peripheral nervous system development GO:0007422 53 32 2,000 1,109E-03 0,01169955 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 1,000 1,111E-03 0,01166497 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,111E-03 0,01161195 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,111E-03 0,01155941 ! cell proliferation in forebrain GO:0021846 10 8 1,000 1,111E-03 0,01150734 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,111E-03 0,01145574 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,111E-03 0,01140459 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,111E-03 0,01135391 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,111E-03 0,01130367 ! astrocyte differentiation GO:0048708 16 8 1,000 1,111E-03 0,01125387 ! melanin metabolic process GO:0006582 12 8 1,000 1,111E-03 0,01120451 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,111E-03 0,01115559 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,111E-03 0,01110708 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 1,000 1,111E-03 0,011059 ! positive regulation of vasodilation GO:0045909 12 8 1,000 1,111E-03 0,01101133 ! Schwann cell differentiation GO:0014037 17 8 1,000 1,111E-03 0,01096407 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,111E-03 0,01091722 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,111E-03 0,01087076 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,111E-03 0,0108247 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,111E-03 0,01077903 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,111E-03 0,01073374 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 1,000 1,111E-03 0,01068883 ! regulation of embryonic development GO:0045995 16 8 1,000 1,111E-03 0,01064429 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,111E-03 0,01060012 ! cell junction organization GO:0034330 63 33 2,000 1,214E-03 0,0115394 ! lipid homeostasis GO:0055088 55 33 2,000 1,214E-03 0,01149191 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,214E-03 0,01144481 ! tube morphogenesis GO:0035239 118 73 3,000 1,237E-03 0,01161028 ! mitochondrion organization GO:0007005 104 73 3,000 1,237E-03 0,01156308 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 1,325E-03 0,0123424 ! neuron migration GO:0001764 46 34 2,000 1,325E-03 0,01229263 ! blood coagulation GO:0007596 116 75 3,000 1,368E-03 0,01263258 GO:0050817|coagulation, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 1,422E-03 0,01308314 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,422E-03 0,01303101 ! telencephalon cell migration GO:0022029 16 9 1,000 1,422E-03 0,0129793 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 1,422E-03 0,012928 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 15 9 1,000 1,422E-03 0,0128771 ! lung alveolus development GO:0048286 17 9 1,000 1,422E-03 0,0128266 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,422E-03 0,0127765 ! T cell selection GO:0045058 18 9 1,000 1,422E-03 0,01272679 ! L-serine metabolic process GO:0006563 13 9 1,000 1,422E-03 0,01267746 ! motor axon guidance GO:0008045 14 9 1,000 1,422E-03 0,01262851 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,422E-03 0,01257994 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,422E-03 0,01253174 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,422E-03 0,01248391 ! oocyte differentiation GO:0009994 12 9 1,000 1,422E-03 0,01243644 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,422E-03 0,01238933 ! spleen development GO:0048536 15 9 1,000 1,422E-03 0,01234258 ! response to nicotine GO:0035094 16 9 1,000 1,422E-03 0,01229618 ! localization within membrane GO:0051668 15 9 1,000 1,422E-03 0,01225013 ! regulation of action potential in neuron GO:0019228 54 35 2,000 1,443E-03 0,012384 ! gland development GO:0048732 148 77 3,000 1,508E-03 0,01289246 ! tissue remodeling GO:0048771 62 36 2,000 1,567E-03 0,01334758 ! negative regulation of muscle development GO:0048635 12 10 1,000 1,77E-03 0,01502356 ! negative regulation of blood pressure GO:0045776 22 10 1,000 1,77E-03 0,01496833 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,77E-03 0,0149135 ! hair follicle morphogenesis GO:0031069 17 10 1,000 1,77E-03 0,01485907 ! blood vessel remodeling GO:0001974 21 10 1,000 1,77E-03 0,01480504 ! positive regulation of heart contraction GO:0045823 14 10 1,000 1,77E-03 0,0147514 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,77E-03 0,01469814 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,77E-03 0,01464527 ! response to X-ray GO:0010165 16 10 1,000 1,77E-03 0,01459278 ! B cell proliferation GO:0042100 14 10 1,000 1,77E-03 0,01454066 ! regulation of sodium ion transport GO:0002028 15 10 1,000 1,77E-03 0,01448892 ! forebrain cell migration GO:0021885 17 10 1,000 1,77E-03 0,01443754 ! fear response GO:0042596 16 10 1,000 1,77E-03 0,01438652 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,77E-03 0,01433587 ! regulation of bone resorption GO:0045124 24 10 1,000 1,77E-03 0,01428556 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,77E-03 0,01423562 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,77E-03 0,01418601 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,77E-03 0,01413676 GO:0043470|regulation of carbohydrate catabolic process, ! hemostasis GO:0007599 125 81 3,000 1,818E-03 0,01446738 ! gliogenesis GO:0042063 71 38 2,000 1,834E-03 0,01454696 ! mesenchymal cell development GO:0014031 64 38 2,000 1,834E-03 0,01449697 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 2,000 1,834E-03 0,01444732 ! regulation of cell adhesion GO:0030155 159 83 3,000 1,988E-03 0,01560784 ! T cell differentiation GO:0030217 65 40 2,000 2,128E-03 0,01664988 ! double-strand break repair GO:0006302 67 40 2,000 2,128E-03 0,01659344 ! B cell differentiation GO:0030183 62 40 2,000 2,128E-03 0,01653738 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 2,128E-03 0,0164817 ! virus-host interaction GO:0019048 17 11 1,000 2,154E-03 0,01662867 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 2,154E-03 0,01657305 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 2,154E-03 0,01651781 GO:0000725|recombinational repair, ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,154E-03 0,01646293 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 2,154E-03 0,01640842 ! bone resorption GO:0045453 16 11 1,000 2,154E-03 0,01635427 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,154E-03 0,01630047 ! temperature homeostasis GO:0001659 16 11 1,000 2,154E-03 0,01624703 ! nitric oxide metabolic process GO:0046209 14 11 1,000 2,154E-03 0,01619393 GO:0006809|nitric oxide biosynthetic process, ! T cell homeostasis GO:0043029 20 11 1,000 2,154E-03 0,01614118 ! regulation of leukocyte migration GO:0002685 24 11 1,000 2,154E-03 0,01608878 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 2,154E-03 0,01603671 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,154E-03 0,01598498 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 2,154E-03 0,01593358 GO:0042130|negative regulation of T cell proliferation, ! regulation of DNA metabolic process GO:0051052 135 85 3,000 2,17E-03 0,01599311 ! regulation of membrane potential GO:0042391 128 85 3,000 2,17E-03 0,01594201 ! skeletal muscle tissue development GO:0007519 123 87 3,000 2,362E-03 0,01729972 GO:0060538|skeletal muscle organ development, ! mitochondrial transport GO:0006839 60 42 2,000 2,45E-03 0,01788969 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 2,45E-03 0,01783308 ! regulation of neurogenesis GO:0050767 153 89 3,000 2,566E-03 0,01861406 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 2,575E-03 0,0186213 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 2,575E-03 0,01856293 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 2,575E-03 0,01850492 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 2,575E-03 0,01844727 ! gland morphogenesis GO:0022612 23 12 1,000 2,575E-03 0,01838998 ! peptidyl-lysine modification GO:0018205 18 12 1,000 2,575E-03 0,01833305 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,575E-03 0,01827646 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,575E-03 0,01822023 ! response to cold GO:0009409 14 12 1,000 2,575E-03 0,01816434 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 2,622E-03 0,01843996 ! leukocyte migration GO:0050900 60 43 2,000 2,622E-03 0,01838374 ! activation of caspase activity GO:0006919 65 43 2,000 2,622E-03 0,01832787 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 2,622E-03 0,01827233 ! leukocyte differentiation GO:0002521 143 90 3,000 2,672E-03 0,01856503 ! hormone metabolic process GO:0042445 121 90 3,000 2,672E-03 0,01850911 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,8E-03 0,01934278 ! regulation of action potential GO:0001508 71 44 2,000 2,8E-03 0,01928487 ! negative regulation of cell migration GO:0030336 92 44 2,000 2,8E-03 0,0192273 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 2,8E-03 0,01917008 ! vascular process in circulatory system GO:0003018 69 45 2,000 2,987E-03 0,02038372 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 3,009E-03 0,02047231 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 3,03E-03 0,02055754 ! regulation of transmembrane transporter activity GO:0022898 19 13 1,000 3,03E-03 0,02049708 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 1,000 3,03E-03 0,02043697 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 3,03E-03 0,02037721 ! regulation of cellular pH GO:0030641 20 13 1,000 3,03E-03 0,02031781 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 3,03E-03 0,02025874 ! cellular pigmentation GO:0033059 24 13 1,000 3,03E-03 0,02020002 ! positive regulation of bone mineralization GO:0030501 19 13 1,000 3,03E-03 0,02014164 ! regulation of RNA stability GO:0043487 28 13 1,000 3,03E-03 0,0200836 ! lymphocyte homeostasis GO:0002260 24 13 1,000 3,03E-03 0,02002588 ! regulation of binding GO:0051098 151 95 3,000 3,249E-03 0,02140856 ! angiogenesis GO:0001525 149 95 3,000 3,249E-03 0,02134739 ! endocrine system development GO:0035270 83 47 2,000 3,381E-03 0,0221573 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 3,381E-03 0,02209435 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 3,381E-03 0,02203176 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 3,52E-03 0,0228717 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 3,52E-03 0,02280727 ! inositol metabolic process GO:0006020 20 14 1,000 3,52E-03 0,02274321 ! limbic system development GO:0021761 25 14 1,000 3,52E-03 0,0226795 ! epidermis morphogenesis GO:0048730 29 14 1,000 3,52E-03 0,02261615 ! pituitary gland development GO:0021983 23 14 1,000 3,52E-03 0,02255315 ! cellular response to starvation GO:0009267 21 14 1,000 3,52E-03 0,0224905 ! lysosomal transport GO:0007041 20 14 1,000 3,52E-03 0,0224282 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 3,52E-03 0,02236625 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 3,52E-03 0,02230463 ! G1/S transition checkpoint GO:0031575 33 14 1,000 3,52E-03 0,02224336 ! positive regulation of biomineral formation GO:0070169 20 14 1,000 3,52E-03 0,02218242 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 3,52E-03 0,02212181 ! negative regulation of inflammatory response GO:0050728 16 14 1,000 3,52E-03 0,02206153 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 3,52E-03 0,02200158 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 3,52E-03 0,02194196 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 3,52E-03 0,02188265 ! positive regulation of caspase activity GO:0043280 72 48 2,000 3,59E-03 0,02225704 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 2,000 3,59E-03 0,02219721 ! regulation of DNA replication GO:0006275 75 48 2,000 3,59E-03 0,0221377 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 3,767E-03 0,02316604 ! regulation of angiogenesis GO:0045765 94 49 2,000 3,807E-03 0,02334736 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 3,807E-03 0,02328527 ! cartilage development GO:0051216 70 49 2,000 3,807E-03 0,0232235 ! regulation of body fluid levels GO:0050878 154 100 3,000 3,905E-03 0,02375983 ! ear development GO:0043583 72 50 2,000 4,031E-03 0,024462 ! skeletal muscle fiber development GO:0048741 73 50 2,000 4,031E-03 0,02439763 ! metencephalon development GO:0022037 19 15 1,000 4,045E-03 0,02441797 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 4,045E-03 0,02435405 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 4,045E-03 0,02429046 ! lipid phosphorylation GO:0046834 23 15 1,000 4,045E-03 0,0242272 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 4,045E-03 0,02416427 ! myoblast differentiation GO:0045445 27 15 1,000 4,045E-03 0,02410167 ! regulation of survival gene product expression GO:0045884 20 15 1,000 4,045E-03 0,02403939 ! cerebral cortex development GO:0021987 29 15 1,000 4,045E-03 0,02397744 ! response to osmotic stress GO:0006970 22 15 1,000 4,045E-03 0,0239158 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 4,045E-03 0,02385448 ! regulation of vasodilation GO:0042312 24 15 1,000 4,045E-03 0,02379347 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 4,045E-03 0,02373277 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 4,045E-03 0,02367238 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 4,045E-03 0,0236123 ! defense response to virus GO:0051607 27 15 1,000 4,045E-03 0,02355252 ! muscle fiber development GO:0048747 74 51 2,000 4,263E-03 0,02476028 ! positive regulation of organelle organization GO:0010638 82 51 2,000 4,263E-03 0,02469791 ! negative regulation of cell motion GO:0051271 104 51 2,000 4,263E-03 0,02463585 ! aging GO:0007568 79 52 2,000 4,503E-03 0,02595829 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 4,603E-03 0,02646989 ! bone remodeling GO:0046849 24 16 1,000 4,603E-03 0,02640388 ! protein amino acid acetylation GO:0006473 28 16 1,000 4,603E-03 0,0263382 ! glial cell development GO:0021782 24 16 1,000 4,603E-03 0,02627285 ! diencephalon development GO:0021536 25 16 1,000 4,603E-03 0,02620782 ! oogenesis GO:0048477 23 16 1,000 4,603E-03 0,02614311 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 4,603E-03 0,02607871 ! negative regulation of translation GO:0017148 22 16 1,000 4,603E-03 0,02601464 ! regulation of mitosis GO:0007088 84 54 2,000 5,008E-03 0,02822945 GO:0051783|regulation of nuclear division, ! negative regulation of defense response GO:0031348 19 17 1,000 5,196E-03 0,02921684 ! forelimb morphogenesis GO:0035136 19 17 1,000 5,196E-03 0,02914558 ! negative regulation of ion transport GO:0043271 20 17 1,000 5,196E-03 0,02907466 ! regulation of viral genome replication GO:0045069 24 17 1,000 5,196E-03 0,02900409 ! vacuolar transport GO:0007034 24 17 1,000 5,196E-03 0,02893387 ! actin filament bundle formation GO:0051017 26 17 1,000 5,196E-03 0,02886398 ! neuromuscular junction development GO:0007528 23 17 1,000 5,196E-03 0,02879443 ! long-chain fatty acid transport GO:0015909 24 17 1,000 5,196E-03 0,02872521 ! peptidyl-serine modification GO:0018209 27 17 1,000 5,196E-03 0,02865632 ! positive regulation of DNA replication GO:0045740 29 18 1,000 5,821E-03 0,0320273 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 5,821E-03 0,03195086 ! somitogenesis GO:0001756 24 18 1,000 5,821E-03 0,03187479 ! cellular response to nutrient levels GO:0031669 27 18 1,000 5,821E-03 0,03179908 ! activation of JUN kinase activity GO:0007257 23 18 1,000 5,821E-03 0,03172372 ! gut development GO:0048565 26 18 1,000 5,821E-03 0,03164873 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 5,821E-03 0,03157408 ! negative regulation of T cell activation GO:0050868 25 18 1,000 5,821E-03 0,03149979 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 5,821E-03 0,03142585 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 6,115E-03 0,03294031 ! lung development GO:0030324 94 59 2,000 6,413E-03 0,03446443 ! actin filament organization GO:0007015 95 59 2,000 6,413E-03 0,03438409 ! myeloid cell differentiation GO:0030099 85 59 2,000 6,413E-03 0,03430413 ! positive regulation of ossification GO:0045778 30 19 1,000 6,478E-03 0,03457104 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 6,478E-03 0,03449102 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 6,478E-03 0,03441136 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 6,478E-03 0,03433207 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 6,478E-03 0,03425315 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 6,478E-03 0,03417459 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 6,478E-03 0,03409638 ! apoptotic nuclear changes GO:0030262 24 19 1,000 6,478E-03 0,03401854 ! response to starvation GO:0042594 30 19 1,000 6,478E-03 0,03394105 ! sex determination GO:0007530 29 19 1,000 6,478E-03 0,03386391 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 6,478E-03 0,03378712 ! renal system process GO:0003014 35 19 1,000 6,478E-03 0,03371068 ! vasodilation GO:0042311 33 19 1,000 6,478E-03 0,03363458 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 6,478E-03 0,03355883 ! cell-matrix adhesion GO:0007160 114 61 2,000 7,035E-03 0,03636012 ! homeostasis of number of cells GO:0048872 84 61 2,000 7,035E-03 0,0362786 ! hindlimb morphogenesis GO:0035137 32 20 1,000 7,168E-03 0,03688324 ! response to ethanol GO:0045471 37 20 1,000 7,168E-03 0,03680091 ! multicellular organismal response to stress GO:0033555 32 20 1,000 7,168E-03 0,03671895 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 7,168E-03 0,03663735 ! pallium development GO:0021543 38 20 1,000 7,168E-03 0,03655612 ! positive regulation of B cell activation GO:0050871 31 20 1,000 7,168E-03 0,03647524 ! respiratory tube development GO:0030323 99 62 2,000 7,359E-03 0,03736146 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 7,691E-03 0,03896306 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 7,89E-03 0,03988239 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 7,89E-03 0,03979493 ! positive regulation of bone remodeling GO:0046852 33 21 1,000 7,89E-03 0,03970785 GO:0034105|positive regulation of tissue remodeling, ! protein amino acid acylation GO:0043543 37 21 1,000 7,89E-03 0,03962115 ! ovarian follicle development GO:0001541 30 21 1,000 7,89E-03 0,03953483 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 7,89E-03 0,03944889 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 7,89E-03 0,03936331 ! fatty acid transport GO:0015908 30 21 1,000 7,89E-03 0,03927811 ! platelet activation GO:0030168 28 21 1,000 7,89E-03 0,03919328 ! regulation of bone mineralization GO:0030500 29 21 1,000 7,89E-03 0,03910881 ! response to cytokine stimulus GO:0034097 47 21 1,000 7,89E-03 0,0390247 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 8,032E-03 0,03964345 ! respiratory system development GO:0060541 100 64 2,000 8,032E-03 0,03955856 ! regulation of caspase activity GO:0043281 97 65 2,000 8,382E-03 0,04119381 ! B cell activation GO:0042113 104 65 2,000 8,382E-03 0,04110597 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 8,382E-03 0,04101852 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 8,643E-03 0,04220419 ! regulation of transmembrane transport GO:0034762 30 22 1,000 8,643E-03 0,04211477 ! molting cycle process GO:0022404 40 22 1,000 8,643E-03 0,04202573 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! vasculogenesis GO:0001570 33 22 1,000 8,643E-03 0,04193707 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 8,643E-03 0,04184878 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 8,643E-03 0,04176086 ! ureteric bud development GO:0001657 32 22 1,000 8,643E-03 0,04167332 ! leukocyte homeostasis GO:0001776 33 22 1,000 8,643E-03 0,04158613 ! neural tube closure GO:0001843 33 22 1,000 8,643E-03 0,04149931 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 8,643E-03 0,04141286 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 9,109E-03 0,04355423 ! regulation of neuron differentiation GO:0045664 107 67 2,000 9,109E-03 0,04346387 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 9,426E-03 0,04488797 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 9,426E-03 0,04479522 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 9,426E-03 0,04470286 ! negative regulation of DNA replication GO:0008156 35 23 1,000 9,426E-03 0,04461088 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 9,426E-03 0,04451928 ! regulation of viral reproduction GO:0050792 32 23 1,000 9,426E-03 0,04442805 ! interaction with host GO:0051701 37 23 1,000 9,426E-03 0,04433719 ! lymphocyte proliferation GO:0046651 36 23 1,000 9,426E-03 0,04424671 ! regulation of biomineral formation GO:0070167 31 23 1,000 9,426E-03 0,04415659 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 9,426E-03 0,04406684 ! liver development GO:0001889 40 23 1,000 9,426E-03 0,04397746 ! primary neural tube formation GO:0014020 35 24 1,000 0,01024073 0,04767949 ! negative regulation of cell development GO:0010721 56 24 1,000 0,01024073 0,04758317 GO:0050768|negative regulation of neurogenesis, ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,01024073 0,04748724 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01024073 0,04739169 ! receptor metabolic process GO:0043112 37 24 1,000 0,01024073 0,04729653 ! base-excision repair GO:0006284 31 24 1,000 0,01024073 0,04720174 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01024073 0,04710734 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01024073 0,04701331 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,01024073 0,04691966 ! muscle cell differentiation GO:0042692 104 71 2,000 0,01066908 0,04878506 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,01066908 0,04868826 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,01108188 0,05047192 ! male gonad development GO:0008584 33 25 1,000 0,01108503 0,05038649 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01108503 0,05028711 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01108503 0,05018812 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01108503 0,05008952 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01108503 0,04999131 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01108503 0,04989348 ! regulation of blood pressure GO:0008217 107 73 2,000 0,01150381 0,05167728 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,01150381 0,05157655 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01195897 0,05351289 ! regulation of pH GO:0006885 36 26 1,000 0,01195897 0,05340899 ! post-embryonic development GO:0009791 42 26 1,000 0,01195897 0,05330548 ! response to nutrient GO:0007584 104 75 2,000 0,01237522 0,05505417 ! regulation of cell morphogenesis GO:0022604 140 76 2,000 0,01282475 0,05694389 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 1,000 0,01286214 0,05699984 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01286214 0,05689023 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 0,01286214 0,05678103 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01286214 0,05667226 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,01375163 0,0604756 ! negative regulation of response to external stimulus GO:0032102 37 28 1,000 0,01379413 0,06054678 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,01379413 0,06043145 GO:0055092|sterol homeostasis, ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01379413 0,06031656 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01379413 0,06020211 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,01379413 0,06008809 ! neural tube formation GO:0001841 41 28 1,000 0,01379413 0,0599745 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01379413 0,05986134 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01379413 0,05974861 ! T cell activation GO:0042110 134 79 2,000 0,01422901 0,06151641 ! forebrain development GO:0030900 131 80 2,000 0,01471573 0,06350128 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01475456 0,0635496 ! ovulation cycle process GO:0022602 41 29 1,000 0,01475456 0,06343081 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,01475456 0,06331247 ! telencephalon development GO:0021537 52 29 1,000 0,01475456 0,06319457 ! regulation of calcium ion transport GO:0051924 37 29 1,000 0,01475456 0,06307711 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,0152118 0,06491122 ! spindle organization GO:0007051 37 30 1,000 0,01574301 0,06705358 ! ovulation cycle GO:0042698 43 30 1,000 0,01574301 0,06692963 ! hindbrain development GO:0030902 45 30 1,000 0,01574301 0,06680615 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,01574301 0,06668312 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01574301 0,06656054 ! response to heat GO:0009408 41 30 1,000 0,01574301 0,06643841 ! mammary gland development GO:0030879 57 31 1,000 0,01675911 0,07059698 ! glial cell differentiation GO:0010001 55 31 1,000 0,01675911 0,07046792 ! xenobiotic metabolic process GO:0006805 44 31 1,000 0,01675911 0,07033933 ! segmentation GO:0035282 41 31 1,000 0,01675911 0,0702112 ! metanephros development GO:0001656 58 31 1,000 0,01675911 0,07008355 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01675911 0,06995635 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01675911 0,06982962 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,01780246 0,07404276 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,01780246 0,07390911 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01780246 0,07377594 ! regulation of protein stability GO:0031647 48 32 1,000 0,01780246 0,07364325 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01780246 0,07351104 ! cytokine production GO:0001816 44 32 1,000 0,01780246 0,0733793 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01780246 0,07324803 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,01838564 0,07551243 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,01887267 0,07737458 ! sister chromatid segregation GO:0000819 46 33 1,000 0,01887267 0,0772369 ! ear morphogenesis GO:0042471 42 33 1,000 0,01887267 0,07709971 ! nucleus organization GO:0006997 49 33 1,000 0,01887267 0,07696301 ! female gonad development GO:0008585 49 33 1,000 0,01887267 0,07682679 ! positive regulation of cell development GO:0010720 54 33 1,000 0,01887267 0,07669106 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01887267 0,0765558 ! cytokinesis GO:0000910 52 33 1,000 0,01887267 0,07642102 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,01894764 0,07658976 ! reproductive developmental process GO:0003006 127 89 2,000 0,01951911 0,07876132 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,01996937 0,08043704 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,01996937 0,08029641 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01996937 0,08015628 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01996937 0,08001663 ! female gamete generation GO:0007292 43 34 1,000 0,01996937 0,07987748 ! polyol metabolic process GO:0019751 44 34 1,000 0,01996937 0,0797388 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,01996937 0,0796006 ! regulation of metal ion transport GO:0010959 47 35 1,000 0,02109218 0,08393081 ! pigment metabolic process GO:0042440 61 35 1,000 0,02109218 0,08378586 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02109218 0,0836414 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,02109218 0,08349744 ! DNA recombination GO:0006310 146 92 2,000 0,02129038 0,08413725 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,02224073 0,08774214 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,02224073 0,0875919 ! negative regulation of binding GO:0051100 58 36 1,000 0,02224073 0,08744217 ! neural tube development GO:0021915 50 36 1,000 0,02224073 0,08729295 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,02224073 0,08714424 GO:0046660|female sex differentiation, ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,02224073 0,08699603 ! response to oxidative stress GO:0006979 141 94 2,000 0,02251866 0,08793366 ! regulation of protein secretion GO:0050708 51 37 1,000 0,02341464 0,0912774 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02461355 0,09578878 ! monocarboxylic acid transport GO:0015718 62 38 1,000 0,02461355 0,09562698 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,02461355 0,09546572 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,02583711 0,10004266 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,02583711 0,09987453 ! male sex differentiation GO:0046661 53 39 1,000 0,02583711 0,09970695 ! JNK cascade GO:0007254 54 39 1,000 0,02583711 0,09953994 ! developmental growth GO:0048589 62 39 1,000 0,02583711 0,09937348 ! synapse organization GO:0050808 55 39 1,000 0,02583711 0,09920758 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,02708494 0,1038256 ! regulation of tube size GO:0035150 60 40 1,000 0,02708494 0,10365284 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02708494 0,10348066 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,02835669 0,10815986 ! glucose transport GO:0015758 52 41 1,000 0,02835669 0,10798079 ! endosome transport GO:0016197 71 41 1,000 0,02835669 0,10780231 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,02835669 0,10762442 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,02835669 0,10744711 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,02835669 0,10727039 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,02965202 0,1119863 ! cellular component disassembly GO:0022411 64 42 1,000 0,02965202 0,11180271 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,02965202 0,11161973 ! hexose transport GO:0008645 54 42 1,000 0,02965202 0,11143734 GO:0015749|monosaccharide transport, ! regulation of cell shape GO:0008360 78 42 1,000 0,02965202 0,11125555 ! positive regulation of binding GO:0051099 59 43 1,000 0,03097058 0,11601356 ! vesicle organization GO:0016050 79 43 1,000 0,03097058 0,11582492 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,0316287 0,11809416 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,0316287 0,11790276 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,0316287 0,11771198 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,0316287 0,11752182 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,0316287 0,11733227 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0316287 0,11714332 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,0316287 0,11695499 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,0316287 0,11676726 ! sleep GO:0030431 11 5 0,000 0,0316287 0,11658014 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,0316287 0,11639361 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,0316287 0,11620768 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,0316287 0,11602234 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,0316287 0,11583759 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,0316287 0,11565343 ! tongue development GO:0043586 6 5 0,000 0,0316287 0,11546985 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,0316287 0,11528685 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,0316287 0,11510444 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,0316287 0,1149226 ! cobalt ion transport GO:0006824 9 5 0,000 0,0316287 0,11474133 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,0316287 0,11456064 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,0316287 0,11438051 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,0316287 0,11420095 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,0316287 0,11402195 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,0316287 0,11384351 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,0316287 0,11366563 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,0316287 0,11348831 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,0316287 0,11331153 ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,0316287 0,11313531 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,0316287 0,11295963 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,0316287 0,1127845 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,0316287 0,11260991 ! malate metabolic process GO:0006108 7 5 0,000 0,0316287 0,11243586 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,0316287 0,11226235 ! behavioral response to pain GO:0048266 7 5 0,000 0,0316287 0,11208938 ! clathrin coat assembly GO:0048268 11 5 0,000 0,0316287 0,11191693 ! phototransduction, visible light GO:0007603 6 5 0,000 0,0316287 0,11174501 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0316287 0,11157363 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! mating behavior GO:0007617 6 5 0,000 0,0316287 0,11140276 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,0316287 0,11123242 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,0316287 0,1110626 ! rhythmic behavior GO:0007622 12 5 0,000 0,0316287 0,1108933 ! copulation GO:0007620 7 5 0,000 0,0316287 0,11072451 ! glial cell fate commitment GO:0021781 12 5 0,000 0,0316287 0,11055624 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,0316287 0,11038847 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,0316287 0,11022122 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,0316287 0,11005447 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,0316287 0,10988822 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,0316287 0,10972248 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,0316287 0,10955724 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,0316287 0,10939249 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0316287 0,10922824 ! response to protozoan GO:0001562 9 5 0,000 0,0316287 0,10906447 ! lymph vessel development GO:0001945 7 5 0,000 0,0316287 0,1089012 ! endochondral ossification GO:0001958 12 5 0,000 0,0316287 0,10873842 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,0316287 0,10857613 ! parathyroid gland development GO:0060017 8 5 0,000 0,0316287 0,10841431 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,0316287 0,10825298 ! anagen GO:0042640 6 5 0,000 0,0316287 0,10809213 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,0316287 0,10793176 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,0316287 0,10777186 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,0316287 0,10761243 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,0316287 0,10745348 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,0316287 0,10729499 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,0316287 0,10713697 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,0316287 0,10697942 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,0316287 0,10682233 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,0316287 0,1066657 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,0316287 0,10650952 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,0316287 0,10635381 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,0316287 0,10619855 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,0316287 0,10604374 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,0316287 0,10588938 ! ovulation GO:0030728 6 5 0,000 0,0316287 0,10573547 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,0316287 0,10558201 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,0316287 0,10542899 ! response to pH GO:0009268 9 5 0,000 0,0316287 0,10527642 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,0316287 0,10512428 ! proline biosynthetic process GO:0006561 6 5 0,000 0,0316287 0,10497259 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,0316287 0,10482133 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,0316287 0,10467051 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,0316287 0,10452012 ! polyol catabolic process GO:0046174 7 5 0,000 0,0316287 0,10437016 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,0316287 0,10422064 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,0316287 0,10407154 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,0316287 0,10392286 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,0316287 0,10377461 ! nerve growth factor processing GO:0032455 7 5 0,000 0,0316287 0,10362679 ! urea metabolic process GO:0019627 6 5 0,000 0,0316287 0,10347938 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,0316287 0,10333239 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,0316287 0,10318582 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,0316287 0,10303967 ! neutrophil activation GO:0042119 5 5 0,000 0,0316287 0,10289392 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,0316287 0,10274859 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,0316287 0,10260367 ! response to food GO:0032094 5 5 0,000 0,0316287 0,10245916 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,0316287 0,10231506 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0316287 0,10217135 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,0316287 0,10202806 ! forebrain neuron development GO:0021884 7 5 0,000 0,0316287 0,10188516 ! melanosome organization GO:0032438 7 5 0,000 0,0316287 0,10174266 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,0316287 0,10160057 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,0316287 0,10145886 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,0316287 0,10131756 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0316287 0,10117664 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,0316287 0,10103612 ! nucleoside transport GO:0015858 6 5 0,000 0,0316287 0,10089598 ! nucleoside salvage GO:0043174 7 5 0,000 0,0316287 0,10075624 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,0316287 0,10061688 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0316287 0,10047791 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,0316287 0,10033932 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,0316287 0,10020111 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,0316287 0,10006328 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,0316287 0,09992583 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0316287 0,09978876 ! depyrimidination GO:0045008 8 5 0,000 0,0316287 0,09965206 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,0316287 0,09951574 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,0316287 0,09937979 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,0316287 0,09924421 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0316287 0,099109 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,0316287 0,09897416 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,0316287 0,09883968 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,0316287 0,09870557 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,0316287 0,09857182 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0316287 0,09843844 ! centrosome duplication GO:0051298 5 5 0,000 0,0316287 0,09830541 ! response to UV-C GO:0010225 6 5 0,000 0,0316287 0,09817275 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,0316287 0,09804044 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,0316287 0,09790849 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,0316287 0,09777689 ! regulation of dendrite development GO:0050773 12 5 0,000 0,0316287 0,09764564 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,0316287 0,09751475 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0316287 0,09738421 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,0316287 0,09725402 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,0316287 0,09712417 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,0316287 0,09699467 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,0316287 0,09686552 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,0316287 0,09673671 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,0316287 0,09660824 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,0316287 0,09648011 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,0316287 0,09635232 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,0316287 0,09622487 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,0316287 0,09609776 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,0316287 0,09597098 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,0316287 0,09584454 ! neural tube patterning GO:0021532 6 5 0,000 0,0316287 0,09571843 ! histone demethylation GO:0016577 9 5 0,000 0,0316287 0,09559265 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,0316287 0,0954672 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0316287 0,09534208 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,0316287 0,09521728 ! enteric nervous system development GO:0048484 8 5 0,000 0,0316287 0,09509282 ! establishment of planar polarity GO:0001736 6 5 0,000 0,0316287 0,09496867 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,0316287 0,09484486 ! muscle cell proliferation GO:0033002 8 5 0,000 0,0316287 0,09472136 ! transcription termination GO:0006353 8 5 0,000 0,0316287 0,09459819 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,0316287 0,09447533 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,0316287 0,09435279 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,0316287 0,09423058 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,0316287 0,09410867 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,0316287 0,09398709 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,0316287 0,09386581 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,0316287 0,09374485 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,0316287 0,0936242 ! apical protein localization GO:0045176 6 5 0,000 0,0316287 0,09350386 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,0316287 0,09338383 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0316287 0,09326411 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0316287 0,09314469 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,0316287 0,09302558 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,0316287 0,09290677 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,0316287 0,09278827 ! glial cell migration GO:0008347 10 5 0,000 0,0316287 0,09267007 ! determination of adult lifespan GO:0008340 8 5 0,000 0,0316287 0,09255217 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,0316287 0,09243457 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,0316287 0,09231726 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,0316287 0,09220026 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,0316287 0,09208355 ! neural plate development GO:0001840 6 5 0,000 0,0316287 0,09196714 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,0316287 0,09185102 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,0316287 0,09173519 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,0316287 0,09161965 ! sensory cilium assembly GO:0035058 6 5 0,000 0,0316287 0,09150441 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,0316287 0,09138945 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,0316287 0,09127479 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! spindle assembly GO:0051225 5 5 0,000 0,0316287 0,09116041 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,0316287 0,09104631 ! organ regeneration GO:0031100 7 5 0,000 0,0316287 0,09093251 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,0316287 0,09081898 ! carnitine metabolic process GO:0009437 5 5 0,000 0,0316287 0,09070574 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,0316287 0,09059278 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,0316287 0,09048011 GO:0055081|anion homeostasis, ! activation of adenylate cyclase activity GO:0007190 76 44 1,000 0,03231201 0,09232003 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,03231201 0,09220549 ! glycolysis GO:0006096 53 44 1,000 0,03231201 0,09209123 ! regulation of ion transport GO:0043269 57 44 1,000 0,03231201 0,09197725 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,03231201 0,09186356 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,03231201 0,09175015 ! cell maturation GO:0048469 60 45 1,000 0,03367598 0,09550524 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 1,000 0,03506215 0,09931397 ! histone modification GO:0016570 68 46 1,000 0,03506215 0,09919181 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,03647018 0,10304843 ! covalent chromatin modification GO:0016569 75 47 1,000 0,03647018 0,10292199 ! positive regulation of cyclase activity GO:0031281 87 47 1,000 0,03647018 0,10279586 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,03647018 0,10267003 ! tRNA transcription GO:0009304 11 6 0,000 0,03783443 0,10638043 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03783443 0,10625054 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03783443 0,10612096 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03783443 0,1059917 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03783443 0,10586276 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03783443 0,10573413 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03783443 0,10560581 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03783443 0,10547781 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03783443 0,10535011 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03783443 0,10522272 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03783443 0,10509564 ! prostate gland development GO:0030850 9 6 0,000 0,03783443 0,10496887 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03783443 0,1048424 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03783443 0,10471623 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03783443 0,10459037 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03783443 0,10446481 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03783443 0,10433956 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03783443 0,1042146 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03783443 0,10408994 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03783443 0,10396558 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03783443 0,10384151 ! neuron adhesion GO:0007158 9 6 0,000 0,03783443 0,10371775 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03783443 0,10359427 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03783443 0,10347109 ! signal peptide processing GO:0006465 8 6 0,000 0,03783443 0,10334821 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03783443 0,10322561 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03783443 0,1031033 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03783443 0,10298129 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03783443 0,10285956 ! opsonization GO:0008228 8 6 0,000 0,03783443 0,10273812 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03783443 0,10261697 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03783443 0,1024961 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03783443 0,10237552 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03783443 0,10225522 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03783443 0,1021352 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03783443 0,10201546 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03783443 0,10189601 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03783443 0,10177683 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03783443 0,10165793 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03783443 0,10153931 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03783443 0,10142097 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03783443 0,1013029 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03783443 0,1011851 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03783443 0,10106758 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03783443 0,10095034 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03783443 0,10083336 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03783443 0,10071665 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03783443 0,10060022 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03783443 0,10048405 ! thymic T cell selection GO:0045061 12 6 0,000 0,03783443 0,10036815 ! protein lipoylation GO:0009249 10 6 0,000 0,03783443 0,10025252 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03783443 0,10013716 ! drug transport GO:0015893 6 6 0,000 0,03783443 0,10002206 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03783443 0,09990722 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03783443 0,09979265 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03783443 0,09967834 ! histidine metabolic process GO:0006547 6 6 0,000 0,03783443 0,09956429 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03783443 0,0994505 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03783443 0,09933697 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03783443 0,0992237 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03783443 0,09911069 ! adenohypophysis development GO:0021984 10 6 0,000 0,03783443 0,09899794 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03783443 0,09888544 ! microtubule nucleation GO:0007020 10 6 0,000 0,03783443 0,0987732 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03783443 0,09866121 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03783443 0,09854948 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03783443 0,098438 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03783443 0,09832677 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03783443 0,09821579 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03783443 0,09810506 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03783443 0,09799458 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03783443 0,09788435 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03783443 0,09777437 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03783443 0,09766463 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03783443 0,09755514 ! neuron apoptosis GO:0051402 8 6 0,000 0,03783443 0,0974459 ! organic alcohol transport GO:0015850 9 6 0,000 0,03783443 0,0973369 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03783443 0,09722814 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03783443 0,09711963 ! carnitine transport GO:0015879 8 6 0,000 0,03783443 0,09701136 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03783443 0,09690333 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03783443 0,09679554 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03783443 0,09668799 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03783443 0,09658068 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03783443 0,0964736 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03783443 0,09636677 ! parturition GO:0007567 12 6 0,000 0,03783443 0,09626017 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03783443 0,0961538 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03783443 0,09604767 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03783443 0,09594177 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03783443 0,09583611 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03783443 0,09573068 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03783443 0,09562548 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03783443 0,09552052 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03783443 0,09541578 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03783443 0,09531127 ! macrophage differentiation GO:0030225 10 6 0,000 0,03783443 0,09520699 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03783443 0,09510294 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03783443 0,09499911 ! interaction with symbiont GO:0051702 8 6 0,000 0,03783443 0,09489552 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03783443 0,09479215 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03783443 0,094689 ! eating behavior GO:0042755 6 6 0,000 0,03783443 0,09458608 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03783443 0,09448338 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03783443 0,0943809 ! response to copper ion GO:0046688 9 6 0,000 0,03783443 0,09427864 ! DNA topological change GO:0006265 8 6 0,000 0,03783443 0,09417661 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03783443 0,0940748 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03783443 0,09397321 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03783443 0,09387183 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03783443 0,09377068 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03783443 0,09366974 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03783443 0,09356902 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03783443 0,09346852 ! gas homeostasis GO:0033483 11 6 0,000 0,03783443 0,09336823 ! hair follicle maturation GO:0048820 7 6 0,000 0,03783443 0,09326816 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03783443 0,0931683 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03783443 0,09306865 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03783443 0,09296922 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03783443 0,09287 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03783443 0,09277099 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03783443 0,09267219 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03783443 0,09257361 ! histone ubiquitination GO:0016574 7 6 0,000 0,03783443 0,09247523 ! regulation of meiosis GO:0040020 10 6 0,000 0,03783443 0,09237706 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03783443 0,0922791 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03783443 0,09218134 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03783443 0,0920838 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03783443 0,09198646 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03783443 0,09188932 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03783443 0,09179239 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03783443 0,09169567 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03783443 0,09159915 ! receptor internalization GO:0031623 9 6 0,000 0,03783443 0,09150283 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03783443 0,09140671 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03783443 0,0913108 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03783443 0,09121508 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03783443 0,09111957 ! protein deubiquitination GO:0016579 8 6 0,000 0,03783443 0,09102426 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03783443 0,09092914 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03783443 0,09083423 ! axonal fasciculation GO:0007413 9 6 0,000 0,03783443 0,09073951 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03783443 0,09064499 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03783443 0,09055067 ! midbrain development GO:0030901 6 6 0,000 0,03783443 0,09045654 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03783443 0,09036261 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03783443 0,09026887 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03783443 0,09017533 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03783443 0,09008198 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03783443 0,08998882 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03783443 0,08989586 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03783443 0,08980308 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03783443 0,0897105 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03783443 0,08961811 ! adult feeding behavior GO:0008343 6 6 0,000 0,03783443 0,08952591 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03783443 0,0894339 ! blastocyst growth GO:0001832 15 6 0,000 0,03783443 0,08934208 ! pigment granule transport GO:0051904 12 6 0,000 0,03783443 0,08925045 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03783443 0,08915901 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03783443 0,08906775 ! catecholamine transport GO:0051937 7 6 0,000 0,03783443 0,08897668 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03783443 0,08888579 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03783443 0,08879509 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03783443 0,08870458 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03783443 0,08861425 ! protein prenylation GO:0018342 10 6 0,000 0,03783443 0,0885241 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03783443 0,08843414 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03783443 0,08834435 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03783443 0,08825476 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03783443 0,08816534 ! heart morphogenesis GO:0003007 65 48 1,000 0,03789975 0,08822816 ! positive regulation of lyase activity GO:0051349 88 48 1,000 0,03789975 0,08813895 ! nuclear export GO:0051168 69 48 1,000 0,03789975 0,08804992 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,03789975 0,08796107 ! germ cell development GO:0007281 68 49 1,000 0,03935052 0,09123608 ! lipid modification GO:0030258 73 50 1,000 0,04082217 0,09455286 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,04231438 0,09791053 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,04382682 0,10130824 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,04382682 0,10120652 ! establishment of organelle localization GO:0051656 85 52 1,000 0,04382682 0,10110501 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04400075 0,10140453 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04400075 0,10130302 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04400075 0,10120172 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04400075 0,10110062 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04400075 0,10099972 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04400075 0,10089902 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04400075 0,10079852 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04400075 0,10069823 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04400075 0,10059813 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04400075 0,10049823 ! reproductive behavior GO:0019098 12 7 0,000 0,04400075 0,10039853 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04400075 0,10029903 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04400075 0,10019972 ! oligopeptide transport GO:0006857 11 7 0,000 0,04400075 0,10010061 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04400075 0,1000017 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04400075 0,09990298 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04400075 0,09980445 ! RNA methylation GO:0001510 11 7 0,000 0,04400075 0,09970612 ! pericardium development GO:0060039 8 7 0,000 0,04400075 0,09960799 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04400075 0,09951005 ! fibril organization GO:0043206 13 7 0,000 0,04400075 0,0994123 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04400075 0,09931474 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04400075 0,09921737 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04400075 0,09912019 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04400075 0,09902321 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04400075 0,09892641 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04400075 0,0988298 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04400075 0,09873338 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04400075 0,09863715 ! chemosensory behavior GO:0007635 9 7 0,000 0,04400075 0,09854111 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04400075 0,09844525 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04400075 0,09834958 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04400075 0,09825409 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04400075 0,09815879 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04400075 0,09806368 ! reflex GO:0060004 12 7 0,000 0,04400075 0,09796875 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04400075 0,097874 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04400075 0,09777944 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04400075 0,09768505 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04400075 0,09759086 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04400075 0,09749684 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04400075 0,097403 ! spinal cord patterning GO:0021511 7 7 0,000 0,04400075 0,09730934 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04400075 0,09721587 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04400075 0,09712257 ! adrenal gland development GO:0030325 17 7 0,000 0,04400075 0,09702945 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04400075 0,09693651 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04400075 0,09684375 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04400075 0,09675116 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04400075 0,09665876 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04400075 0,09656652 ! endosome organization GO:0007032 10 7 0,000 0,04400075 0,09647447 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04400075 0,09638259 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04400075 0,09629088 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04400075 0,09619935 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04400075 0,09610799 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04400075 0,09601681 ! galactose metabolic process GO:0006012 10 7 0,000 0,04400075 0,0959258 ! vesicle fusion GO:0006906 15 7 0,000 0,04400075 0,09583496 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04400075 0,09574429 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04400075 0,0956538 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04400075 0,09556347 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04400075 0,09547332 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04400075 0,09538333 ! retinol metabolic process GO:0042572 9 7 0,000 0,04400075 0,09529352 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04400075 0,09520387 ! rRNA modification GO:0000154 12 7 0,000 0,04400075 0,0951144 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04400075 0,09502509 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04400075 0,09493594 ! intermediate filament organization GO:0045109 11 7 0,000 0,04400075 0,09484697 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04400075 0,09475816 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04400075 0,09466952 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04400075 0,09458104 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04400075 0,09449273 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04400075 0,09440459 ! response to tropane GO:0014073 13 7 0,000 0,04400075 0,0943166 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! melanosome localization GO:0032400 10 7 0,000 0,04400075 0,09422879 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04400075 0,09414113 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04400075 0,09405364 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04400075 0,09396631 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04400075 0,09387914 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04400075 0,09379214 ! mast cell activation GO:0045576 9 7 0,000 0,04400075 0,09370529 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04400075 0,09361861 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04400075 0,09353209 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04400075 0,09344572 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04400075 0,09335952 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04400075 0,09327347 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04400075 0,09318758 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04400075 0,09310186 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04400075 0,09301628 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04400075 0,09293087 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04400075 0,09284561 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04400075 0,09276051 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04400075 0,09267556 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04400075 0,09259077 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04400075 0,09250614 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04400075 0,09242166 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04400075 0,09233733 ! diuresis GO:0030146 12 7 0,000 0,04400075 0,09225316 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04400075 0,09216914 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04400075 0,09208527 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04400075 0,09200156 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04400075 0,091918 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04400075 0,09183459 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04400075 0,09175133 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04400075 0,09166822 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04400075 0,09158526 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04400075 0,09150246 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04400075 0,0914198 ! lymph node development GO:0048535 9 7 0,000 0,04400075 0,09133729 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04400075 0,09125493 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04400075 0,09117272 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04400075 0,09109065 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04400075 0,09100874 ! ATP catabolic process GO:0006200 10 7 0,000 0,04400075 0,09092697 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04400075 0,09084535 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04400075 0,09076387 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04400075 0,09068254 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04400075 0,09060136 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04400075 0,09052032 ! muscle adaptation GO:0043500 12 7 0,000 0,04400075 0,09043943 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04400075 0,09035868 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04400075 0,09027807 ! retina homeostasis GO:0001895 9 7 0,000 0,04400075 0,09019761 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04400075 0,09011729 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04400075 0,09003711 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04400075 0,08995708 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04400075 0,08987719 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04400075 0,08979744 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04400075 0,08971783 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,04535919 0,0924058 ! kidney development GO:0001822 90 53 1,000 0,04535919 0,09232403 ! cell projection assembly GO:0030031 76 53 1,000 0,04535919 0,09224239 ! glucose catabolic process GO:0006007 66 54 1,000 0,04691118 0,09531423 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,04691118 0,0952301 ! DNA catabolic process GO:0006308 67 54 1,000 0,04691118 0,09514613 ! detection of external stimulus GO:0009581 66 54 1,000 0,04691118 0,0950623 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,04691118 0,09497862 ! exocytosis GO:0006887 74 55 1,000 0,04848246 0,09807358 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,05007274 0,1012015 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05012789 0,10122402 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05012789 0,10113523 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05012789 0,10104659 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05012789 0,10095811 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05012789 0,10086978 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05012789 0,10078161 ! phosphate transport GO:0006817 10 8 0,000 0,05012789 0,10069359 ! N-glycan processing GO:0006491 12 8 0,000 0,05012789 0,10060572 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05012789 0,10051801 ! UTP metabolic process GO:0046051 8 8 0,000 0,05012789 0,10043045 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05012789 0,10034304 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05012789 0,10025579 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05012789 0,10016869 ! succinate metabolic process GO:0006105 14 8 0,000 0,05012789 0,10008173 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05012789 0,09999493 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05012789 0,09990828 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05012789 0,09982178 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05012789 0,09973543 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05012789 0,09964923 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05012789 0,09956318 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05012789 0,09947727 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05012789 0,09939152 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05012789 0,09930591 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05012789 0,09922045 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05012789 0,09913513 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05012789 0,09904996 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05012789 0,09896494 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05012789 0,09888007 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05012789 0,09879534 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05012789 0,09871075 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05012789 0,09862631 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05012789 0,09854202 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05012789 0,09845786 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05012789 0,09837385 ! macrophage activation GO:0042116 12 8 0,000 0,05012789 0,09828999 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05012789 0,09820627 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05012789 0,09812269 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05012789 0,09803925 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05012789 0,09795595 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05012789 0,0978728 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05012789 0,09778979 ! ruffle organization GO:0031529 11 8 0,000 0,05012789 0,09770691 ! osteoblast development GO:0002076 13 8 0,000 0,05012789 0,09762418 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05012789 0,09754159 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05012789 0,09745914 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05012789 0,09737682 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05012789 0,09729465 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05012789 0,09721261 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05012789 0,09713071 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05012789 0,09704895 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05012789 0,09696733 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05012789 0,09688585 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05012789 0,0968045 ! segment specification GO:0007379 10 8 0,000 0,05012789 0,09672329 ! cellular extravasation GO:0045123 11 8 0,000 0,05012789 0,09664221 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05012789 0,09656127 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05012789 0,09648047 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05012789 0,0963998 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05012789 0,09631926 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05012789 0,09623886 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05012789 0,0961586 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05012789 0,09607846 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05012789 0,09599847 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05012789 0,0959186 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05012789 0,09583887 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05012789 0,09575927 ! icosanoid secretion GO:0032309 12 8 0,000 0,05012789 0,0956798 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05012789 0,09560046 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05012789 0,09552126 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05012789 0,09544218 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05012789 0,09536324 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05012789 0,09528443 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05012789 0,09520575 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05012789 0,09512719 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05012789 0,09504877 ! sterol catabolic process GO:0016127 9 8 0,000 0,05012789 0,09497048 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05012789 0,09489231 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05012789 0,09481427 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05012789 0,09473637 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05012789 0,09465859 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05012789 0,09458093 ! prophase GO:0051324 11 8 0,000 0,05012789 0,09450341 ! S phase GO:0051320 8 8 0,000 0,05012789 0,09442601 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05012789 0,09434874 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05012789 0,09427159 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05012789 0,09419457 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05012789 0,09411768 ! hormone catabolic process GO:0042447 13 8 0,000 0,05012789 0,09404091 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05012789 0,09396427 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05012789 0,09388775 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05012789 0,09381136 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05012789 0,09373509 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05012789 0,09365894 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05012789 0,09358292 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05012789 0,09350702 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05012789 0,09343125 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05012789 0,09335559 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05012789 0,09328006 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05012789 0,09320465 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05012789 0,09312937 ! carbohydrate transport GO:0008643 74 57 1,000 0,05168172 0,09593862 ! chromosome segregation GO:0007059 83 57 1,000 0,05168172 0,09586125 ! secondary metabolic process GO:0019748 84 57 1,000 0,05168172 0,095784 ! developmental maturation GO:0021700 75 57 1,000 0,05168172 0,09570688 ! gonad development GO:0008406 79 57 1,000 0,05168172 0,09562988 ! viral reproductive process GO:0022415 87 58 1,000 0,05330908 0,09856181 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,05495455 0,10152245 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05621612 0,10376973 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05621612 0,10368651 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05621612 0,10360343 ! CTP metabolic process GO:0046036 9 9 0,000 0,05621612 0,10352048 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05621612 0,10343766 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,05621612 0,10335498 ! GTP metabolic process GO:0046039 9 9 0,000 0,05621612 0,10327243 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05621612 0,10319001 ! social behavior GO:0035176 14 9 0,000 0,05621612 0,10310772 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05621612 0,10302556 ! artery development GO:0060840 19 9 0,000 0,05621612 0,10294353 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05621612 0,10286164 ! response to pain GO:0048265 16 9 0,000 0,05621612 0,10277987 ! protein complex disassembly GO:0043241 17 9 0,000 0,05621612 0,10269824 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05621612 0,10261673 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05621612 0,10253535 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05621612 0,1024541 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05621612 0,10237298 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05621612 0,10229199 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05621612 0,10221113 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05621612 0,10213039 ! protein targeting to ER GO:0045047 19 9 0,000 0,05621612 0,10204979 ! endoderm development GO:0007492 12 9 0,000 0,05621612 0,10196931 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05621612 0,10188895 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05621612 0,10180872 ! arginine catabolic process GO:0006527 10 9 0,000 0,05621612 0,10172862 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05621612 0,10164865 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05621612 0,1015688 GO:0010833|telomere maintenance via telomere lengthening, ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05621612 0,10148907 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05621612 0,10140947 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05621612 0,10133 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05621612 0,10125065 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05621612 0,10117142 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05621612 0,10109232 ! mannose metabolic process GO:0006013 9 9 0,000 0,05621612 0,10101334 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05621612 0,10093449 ! receptor clustering GO:0043113 15 9 0,000 0,05621612 0,10085576 ! epithelial cell development GO:0002064 10 9 0,000 0,05621612 0,10077715 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05621612 0,10069866 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05621612 0,1006203 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05621612 0,10054205 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05621612 0,10046393 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05621612 0,10038593 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05621612 0,10030805 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05621612 0,10023029 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05621612 0,10015266 ! DNA ligation GO:0006266 14 9 0,000 0,05621612 0,10007514 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05621612 0,09999774 ! response to amine stimulus GO:0014075 13 9 0,000 0,05621612 0,09992046 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05621612 0,0998433 ! erythrocyte development GO:0048821 11 9 0,000 0,05621612 0,09976627 ! renal water homeostasis GO:0003091 14 9 0,000 0,05621612 0,09968934 ! postreplication repair GO:0006301 11 9 0,000 0,05621612 0,09961254 ! mRNA cleavage GO:0006379 13 9 0,000 0,05621612 0,09953586 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05621612 0,09945929 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05621612 0,09938284 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05621612 0,09930651 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05621612 0,0992303 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05621612 0,0991542 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,05621612 0,09907822 ! acid secretion GO:0046717 14 9 0,000 0,05621612 0,09900236 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05621612 0,09892661 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05621612 0,09885098 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05621612 0,09877546 ! purine base metabolic process GO:0006144 18 9 0,000 0,05621612 0,09870006 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05621612 0,09862477 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,05621612 0,0985496 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05621612 0,09847455 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05621612 0,0983996 ! detection of calcium ion GO:0005513 13 9 0,000 0,05621612 0,09832478 ! blastocyst formation GO:0001825 12 9 0,000 0,05621612 0,09825006 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05621612 0,09817546 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05621612 0,09810097 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05621612 0,0980266 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05621612 0,09795233 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05621612 0,09787818 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05621612 0,09780414 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05621612 0,09773022 ! prepulse inhibition GO:0060134 14 9 0,000 0,05621612 0,0976564 ! embryonic placenta development GO:0001892 12 9 0,000 0,05621612 0,0975827 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05621612 0,09750911 ! insulin secretion GO:0030073 17 9 0,000 0,05621612 0,09743563 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05621612 0,09736226 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05621612 0,097289 ! nucleus localization GO:0051647 15 9 0,000 0,05621612 0,09721585 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05621612 0,09714281 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,05661781 0,09776349 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,05661781 0,09769015 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,05661781 0,09761692 GO:0035113|embryonic appendage morphogenesis, ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,05829859 0,10043952 ! urogenital system development GO:0001655 101 61 1,000 0,05829859 0,10036434 ! organelle localization GO:0051640 96 62 1,000 0,05999659 0,10321029 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,06171153 0,1060811 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,06171153 0,10600188 ! viral reproduction GO:0016032 92 63 1,000 0,06171153 0,10592277 ! regulation of lipase activity GO:0060191 109 63 1,000 0,06171153 0,10584378 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06226567 0,10671464 ! neuron fate specification GO:0048665 11 10 0,000 0,06226567 0,10663518 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06226567 0,10655584 ! thyroid gland development GO:0030878 19 10 0,000 0,06226567 0,10647661 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06226567 0,10639751 ! synapsis GO:0007129 13 10 0,000 0,06226567 0,10631852 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06226567 0,10623965 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06226567 0,10616089 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06226567 0,10608226 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,06226567 0,10600373 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06226567 0,10592533 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,06226567 0,10584704 ! androgen metabolic process GO:0008209 13 10 0,000 0,06226567 0,10576887 ! phospholipid efflux GO:0033700 16 10 0,000 0,06226567 0,10569081 ! hippocampus development GO:0021766 19 10 0,000 0,06226567 0,10561287 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,06226567 0,10553504 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06226567 0,10545732 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,06226567 0,10537972 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06226567 0,10530224 ! pathogenesis GO:0009405 13 10 0,000 0,06226567 0,10522487 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06226567 0,10514761 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06226567 0,10507047 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06226567 0,10499344 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06226567 0,10491652 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06226567 0,10483971 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06226567 0,10476302 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06226567 0,10468644 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06226567 0,10460997 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06226567 0,10453361 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06226567 0,10445736 ! lipid digestion GO:0044241 15 10 0,000 0,06226567 0,10438123 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06226567 0,1043052 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06226567 0,10422929 ! UV protection GO:0009650 14 10 0,000 0,06226567 0,10415349 ! entry into host cell GO:0030260 20 10 0,000 0,06226567 0,10407779 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06226567 0,10400221 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06226567 0,10392674 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06226567 0,10385137 ! regulation of organ growth GO:0046620 11 10 0,000 0,06226567 0,10377612 ! response to dsRNA GO:0043331 18 10 0,000 0,06226567 0,10370097 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06226567 0,10362594 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06226567 0,10355101 ! embryonic axis specification GO:0000578 12 10 0,000 0,06226567 0,10347619 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06226567 0,10340148 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06226567 0,10332687 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06226567 0,10325238 ! cranial nerve development GO:0021545 12 10 0,000 0,06226567 0,10317799 ! fucose catabolic process GO:0019317 16 10 0,000 0,06226567 0,1031037 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,06226567 0,10302953 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06226567 0,10295546 ! protein sumoylation GO:0016925 12 10 0,000 0,06226567 0,1028815 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06226567 0,10280764 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06226567 0,10273389 ! zymogen activation GO:0031638 14 10 0,000 0,06226567 0,10266025 ! salivary gland development GO:0007431 22 10 0,000 0,06226567 0,10258671 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06226567 0,10251328 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06226567 0,10243995 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06226567 0,10236672 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06226567 0,1022936 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06226567 0,10222059 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06226567 0,10214768 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06226567 0,10207487 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06226567 0,10200217 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06226567 0,10192957 ! detection of bacterium GO:0016045 10 10 0,000 0,06226567 0,10185707 ! embryonic gut development GO:0048566 11 10 0,000 0,06226567 0,10178468 ! activation of innate immune response GO:0002218 10 10 0,000 0,06226567 0,10171239 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06226567 0,1016402 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,06226567 0,10156812 ! developmental induction GO:0031128 13 10 0,000 0,06226567 0,10149613 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,06226567 0,10142425 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06226567 0,10135247 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06226567 0,1012808 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06226567 0,10120922 ! appendage morphogenesis GO:0035107 93 64 1,000 0,06344312 0,10305027 GO:0035108|limb morphogenesis, ! hexose catabolic process GO:0019320 82 64 1,000 0,06344312 0,10297754 ! adaptive immune response GO:0002250 94 64 1,000 0,06344312 0,10290492 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,06519109 0,10566562 ! appendage development GO:0048736 94 65 1,000 0,06519109 0,10559121 GO:0060173|limb development, ! axon guidance GO:0007411 99 66 1,000 0,06695516 0,10837218 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,06695516 0,10829597 ! rRNA transcription GO:0009303 17 11 0,000 0,06827679 0,11035602 ! respiratory burst GO:0045730 14 11 0,000 0,06827679 0,11027852 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,06827679 0,11020113 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,06827679 0,11012385 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,06827679 0,11004668 ! filopodium assembly GO:0046847 19 11 0,000 0,06827679 0,10996962 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,06827679 0,10989266 ! RNA polyadenylation GO:0043631 19 11 0,000 0,06827679 0,10981582 ! mating GO:0007618 14 11 0,000 0,06827679 0,10973907 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,06827679 0,10966244 ! T cell proliferation GO:0042098 20 11 0,000 0,06827679 0,10958591 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,06827679 0,10950949 ! regulated secretory pathway GO:0045055 14 11 0,000 0,06827679 0,10943318 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,06827679 0,10935697 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,06827679 0,10928087 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,06827679 0,10920488 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,06827679 0,10912899 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,06827679 0,10905321 ! syncytium formation GO:0006949 15 11 0,000 0,06827679 0,10897753 ! plasma membrane organization GO:0007009 18 11 0,000 0,06827679 0,10890195 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,06827679 0,10882648 ! mitotic spindle organization GO:0007052 15 11 0,000 0,06827679 0,10875112 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,06827679 0,10867586 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,06827679 0,1086007 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,06827679 0,10852565 ! adult heart development GO:0007512 11 11 0,000 0,06827679 0,1084507 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,06827679 0,10837586 ! L-glutamate transport GO:0015813 16 11 0,000 0,06827679 0,10830111 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,06827679 0,10822648 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,06827679 0,10815194 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,06827679 0,10807751 ! stem cell development GO:0048864 29 11 0,000 0,06827679 0,10800317 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,06827679 0,10792895 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,06827679 0,10785482 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,06827679 0,10778079 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,06827679 0,10770687 ! vasoconstriction GO:0042310 15 11 0,000 0,06827679 0,10763305 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,06827679 0,10755933 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,06827679 0,10748571 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,06827679 0,10741219 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,06827679 0,10733877 ! ribosome assembly GO:0042255 13 11 0,000 0,06827679 0,10726545 ! histone deacetylation GO:0016575 13 11 0,000 0,06827679 0,10719223 ! chromatin silencing GO:0006342 19 11 0,000 0,06827679 0,10711911 ! nucleosome positioning GO:0016584 13 11 0,000 0,06827679 0,10704609 ! regulation of isotype switching GO:0045191 19 11 0,000 0,06827679 0,10697317 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,06827679 0,10690035 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,06827679 0,10682763 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,06827679 0,10675501 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,06827679 0,10668248 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,06827679 0,10661006 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,06827679 0,10653773 ! male genitalia development GO:0030539 13 11 0,000 0,06827679 0,1064655 ! cholesterol efflux GO:0033344 19 11 0,000 0,06827679 0,10639337 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,06827679 0,10632134 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,06827679 0,1062494 ! germ cell migration GO:0008354 18 11 0,000 0,06827679 0,10617756 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,06827679 0,10610582 ! defense response to fungus GO:0050832 12 11 0,000 0,06827679 0,10603418 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,06827679 0,10596263 ! lysogeny GO:0030069 18 11 0,000 0,06827679 0,10589118 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,06827679 0,10581982 ! acrosome reaction GO:0007340 13 11 0,000 0,06827679 0,10574856 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,06827679 0,1056774 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,07053051 0,10909225 ! rhythmic process GO:0048511 105 68 1,000 0,07053051 0,10901894 ! response to metal ion GO:0010038 103 70 1,000 0,07416701 0,11456288 ! humoral immune response GO:0006959 86 70 1,000 0,07416701 0,11448599 ! regulation of catabolic process GO:0009894 106 70 1,000 0,07416701 0,11440921 ! lactation GO:0007595 20 12 0,000 0,07424972 0,11446002 ! reproductive cellular process GO:0048610 14 12 0,000 0,07424972 0,11438335 ! tRNA modification GO:0006400 14 12 0,000 0,07424972 0,11430679 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,07424972 0,11423033 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,07424972 0,11415398 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,07424972 0,11407772 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,07424972 0,11400157 ! non-recombinational repair GO:0000726 19 12 0,000 0,07424972 0,11392551 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,07424972 0,11384956 ! peroxisomal transport GO:0043574 21 12 0,000 0,07424972 0,11377372 ! cartilage condensation GO:0001502 18 12 0,000 0,07424972 0,11369797 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,07424972 0,11362232 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,07424972 0,11354677 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,07424972 0,11347133 ! heart looping GO:0001947 15 12 0,000 0,07424972 0,11339598 ! palate development GO:0060021 15 12 0,000 0,07424972 0,11332073 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,07424972 0,11324559 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,07424972 0,11317054 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,07424972 0,11309559 ! arginine metabolic process GO:0006525 13 12 0,000 0,07424972 0,11302075 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,07424972 0,112946 ! methionine metabolic process GO:0006555 13 12 0,000 0,07424972 0,11287135 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,07424972 0,11279679 ! Golgi organization GO:0007030 18 12 0,000 0,07424972 0,11272234 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,07424972 0,11264799 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,07424972 0,11257373 ! monoamine transport GO:0015844 13 12 0,000 0,07424972 0,11249957 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07424972 0,11242551 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,07424972 0,11235154 ! L-amino acid transport GO:0015807 20 12 0,000 0,07424972 0,11227768 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,07424972 0,11220391 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,07424972 0,11213023 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,07424972 0,11205666 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07424972 0,11198318 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,07424972 0,11190979 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,07424972 0,11183651 ! cerebellum development GO:0021549 13 12 0,000 0,07424972 0,11176332 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,07424972 0,11169022 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,07424972 0,11161722 ! histone methylation GO:0016571 15 12 0,000 0,07424972 0,11154432 ! autonomic nervous system development GO:0048483 23 12 0,000 0,07424972 0,11147151 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,07424972 0,11139879 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,07424972 0,11132617 ! regulation of epidermis development GO:0045682 17 12 0,000 0,07424972 0,11125365 ! intestinal absorption GO:0050892 19 12 0,000 0,07424972 0,11118122 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,07424972 0,11110888 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,07424972 0,11103664 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,07424972 0,11096449 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,07424972 0,11089243 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,07424972 0,11082047 ! microspike assembly GO:0030035 23 12 0,000 0,07424972 0,1107486 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,07424972 0,11067683 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,07600753 0,11322365 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,07600753 0,11315037 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,07786255 0,11583691 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,08018469 0,11921447 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08018469 0,11913746 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08018469 0,11906055 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,08018469 0,11898374 ! water transport GO:0006833 17 13 0,000 0,08018469 0,11890702 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08018469 0,11883041 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08018469 0,11875389 ! lipid localization GO:0010876 24 13 0,000 0,08018469 0,11867747 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08018469 0,11860115 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08018469 0,11852493 ! organelle fusion GO:0048284 28 13 0,000 0,08018469 0,11844881 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08018469 0,11837278 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08018469 0,11829685 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08018469 0,11822102 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08018469 0,11814529 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08018469 0,11806965 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08018469 0,11799411 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08018469 0,11791866 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08018469 0,11784332 ! NAD metabolic process GO:0019674 21 13 0,000 0,08018469 0,11776807 ! exocrine system development GO:0035272 27 13 0,000 0,08018469 0,11769291 ! bone mineralization GO:0030282 15 13 0,000 0,08018469 0,11761785 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08018469 0,11754289 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08018469 0,11746802 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08018469 0,11739325 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08018469 0,11731857 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08018469 0,11724399 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08018469 0,1171695 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,08018469 0,11709511 ! genitalia development GO:0048806 15 13 0,000 0,08018469 0,11702081 ! tissue regeneration GO:0042246 21 13 0,000 0,08018469 0,1169466 ! cofactor transport GO:0051181 19 13 0,000 0,08018469 0,11687249 ! NADP metabolic process GO:0006739 18 13 0,000 0,08018469 0,11679847 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08018469 0,11672455 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08018469 0,11665072 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08018469 0,11657699 ! gas transport GO:0015669 18 13 0,000 0,08018469 0,11650334 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08018469 0,11642979 ! regulation of axon extension GO:0030516 23 13 0,000 0,08018469 0,11635634 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08018469 0,11628297 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08018469 0,1162097 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08018469 0,11613652 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08018469 0,11606343 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08018469 0,11599044 ! protein import into nucleus GO:0006606 118 74 1,000 0,08161506 0,11798531 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,08161506 0,1179112 ! response to inorganic substance GO:0010035 115 75 1,000 0,08351204 0,12057608 ! nuclear import GO:0051170 121 75 1,000 0,08351204 0,12050043 ! amine biosynthetic process GO:0009309 97 76 1,000 0,08542251 0,12317979 ! superoxide anion generation GO:0042554 18 14 0,000 0,08608196 0,12405294 ! neuron maturation GO:0042551 21 14 0,000 0,08608196 0,12397527 ! regulation of S phase GO:0033261 18 14 0,000 0,08608196 0,12389768 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,08608196 0,1238202 ! myotube differentiation GO:0014902 21 14 0,000 0,08608196 0,12374281 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08608196 0,12366552 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08608196 0,12358833 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08608196 0,12351123 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08608196 0,12343423 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08608196 0,12335732 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08608196 0,12328051 ! response to cAMP GO:0051591 19 14 0,000 0,08608196 0,1232038 ! startle response GO:0001964 21 14 0,000 0,08608196 0,12312718 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,08608196 0,12305065 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08608196 0,12297422 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08608196 0,12289789 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08608196 0,12282165 ! glycine metabolic process GO:0006544 22 14 0,000 0,08608196 0,12274551 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,08608196 0,12266945 GO:0031114|regulation of microtubule depolymerization, ! regulation of heart rate GO:0002027 23 14 0,000 0,08608196 0,1225935 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08608196 0,12251764 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08608196 0,12244187 ! embryo implantation GO:0007566 27 14 0,000 0,08608196 0,12236619 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08608196 0,12229061 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08608196 0,12221512 ! axon cargo transport GO:0008088 27 14 0,000 0,08608196 0,12213973 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08608196 0,12206443 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08608196 0,12198922 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08608196 0,1219141 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08608196 0,12183908 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08608196 0,12176415 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08608196 0,12168931 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08608196 0,12161456 ! muscle maintenance GO:0046716 19 14 0,000 0,08608196 0,1215399 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08608196 0,12146534 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08608196 0,12139086 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08608196 0,12131648 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,08608196 0,12124219 ! cell killing GO:0001906 20 14 0,000 0,08608196 0,12116799 ! cilium assembly GO:0042384 20 14 0,000 0,08608196 0,12109388 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08608196 0,12101987 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,08734621 0,12272223 ! regulation of DNA binding GO:0051101 119 77 1,000 0,08734621 0,12264731 ! sex differentiation GO:0007548 105 77 1,000 0,08734621 0,12257248 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,08928291 0,12521384 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,09123236 0,12786986 ! regulation of lyase activity GO:0051339 133 79 1,000 0,09123236 0,12779198 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,09194175 0,12870725 ! positive regulation of cell size GO:0045793 20 15 0,000 0,09194175 0,12862896 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,09194175 0,12855077 ! skin development GO:0043588 25 15 0,000 0,09194175 0,12847267 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,09194175 0,12839467 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,09194175 0,12831676 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,09194175 0,12823894 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,09194175 0,12816122 ! bile acid metabolic process GO:0008206 22 15 0,000 0,09194175 0,1280836 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,09194175 0,12800606 ! adult walking behavior GO:0007628 25 15 0,000 0,09194175 0,12792863 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,09194175 0,12785128 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,09194175 0,12777403 ! centrosome cycle GO:0007098 16 15 0,000 0,09194175 0,12769687 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,09194175 0,12761981 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,09194175 0,12754283 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,09194175 0,12746595 ! vesicle coating GO:0006901 25 15 0,000 0,09194175 0,12738917 ! DNA integration GO:0015074 22 15 0,000 0,09194175 0,12731247 ! peptide secretion GO:0002790 27 15 0,000 0,09194175 0,12723587 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,09194175 0,12715936 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,09194175 0,12708294 ! neuron recognition GO:0008038 22 15 0,000 0,09194175 0,12700662 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,09194175 0,12693038 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,09194175 0,12685424 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,09194175 0,12677819 ! biomineral formation GO:0031214 18 15 0,000 0,09194175 0,12670223 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,09194175 0,12662636 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,09194175 0,12655058 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,09194175 0,12647489 ! dopamine metabolic process GO:0042417 30 15 0,000 0,09194175 0,12639929 ! organic cation transport GO:0015695 19 15 0,000 0,09194175 0,12632379 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,09194175 0,12624837 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,09194175 0,12617304 ! peptide hormone processing GO:0016486 19 15 0,000 0,09194175 0,1260978 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,09194175 0,12602266 ! chromatin assembly GO:0031497 102 80 1,000 0,09319433 0,12766346 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 1,000 0,09319433 0,12758747 ! protein localization in nucleus GO:0034504 133 80 1,000 0,09319433 0,12751157 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,09516857 0,13013538 ! response to protein stimulus GO:0051789 111 81 1,000 0,09516857 0,13005806 ! regulation of neurological system process GO:0031644 122 81 1,000 0,09516857 0,12998083 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,09516857 0,12990369 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,09715485 0,13253628 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,09715485 0,13245771 ! protein secretion GO:0009306 27 16 0,000 0,0977643 0,13320965 ! hormone secretion GO:0046879 25 16 0,000 0,0977643 0,13313078 ! endothelial cell migration GO:0043542 22 16 0,000 0,0977643 0,13305201 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,0977643 0,13297332 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0977643 0,13289473 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,0977643 0,13281624 ! patterning of blood vessels GO:0001569 24 16 0,000 0,0977643 0,13273783 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,0977643 0,13265952 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,0977643 0,1325813 ! protein polyubiquitination GO:0000209 26 16 0,000 0,0977643 0,13250318 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,0977643 0,13242514 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,0977643 0,1323472 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,0977643 0,13226935 ! fructose metabolic process GO:0006000 20 16 0,000 0,0977643 0,13219159 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,0977643 0,13211392 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,0977643 0,13203634 ! protein export from nucleus GO:0006611 24 16 0,000 0,0977643 0,13195886 ! negative regulation of immune response GO:0050777 28 16 0,000 0,0977643 0,13188146 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,0977643 0,13180416 ! DNA replication initiation GO:0006270 25 16 0,000 0,0977643 0,13172694 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,0977643 0,13164982 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,0977643 0,13157278 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,0977643 0,13149584 ! neural crest cell migration GO:0001755 24 16 0,000 0,0977643 0,13141899 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,0977643 0,13134222 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,0977643 0,13126555 ! steroid catabolic process GO:0006706 22 16 0,000 0,0977643 0,13118897 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,0977643 0,13111247 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,0977643 0,13103607 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,0977643 0,13095975 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,0977643 0,13088352 ! sperm-egg recognition GO:0035036 16 16 0,000 0,0977643 0,13080738 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,0977643 0,13073133 ! nerve development GO:0021675 18 16 0,000 0,0977643 0,13065537 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,0977643 0,13057949 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,0977643 0,13050371 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,09915295 0,13228061 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,10116262 0,13488349 ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,10116262 0,13480534 ! transcription initiation GO:0006352 118 85 1,000 0,10318365 0,13741887 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,10318365 0,13733934 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,10354985 0,13774705 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,10354985 0,13766743 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,10354985 0,1375879 ! glycerol metabolic process GO:0006071 20 17 0,000 0,10354985 0,13750846 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,10354985 0,13742911 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,10354985 0,13734986 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,10354985 0,13727069 ! signal complex assembly GO:0007172 29 17 0,000 0,10354985 0,13719162 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,10354985 0,13711264 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,10354985 0,13703375 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,10354985 0,13695495 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,10354985 0,13687624 ! memory GO:0007613 25 17 0,000 0,10354985 0,13679762 ! keratinization GO:0031424 17 17 0,000 0,10354985 0,13671909 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,10354985 0,13664065 ! retinoid metabolic process GO:0001523 22 17 0,000 0,10354985 0,1365623 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,10354985 0,13648404 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,10354985 0,13640587 GO:0032392|DNA geometric change, ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,10354985 0,13632779 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,10354985 0,1362498 ! membrane budding GO:0006900 29 17 0,000 0,10354985 0,1361719 ! heme metabolic process GO:0042168 27 17 0,000 0,10354985 0,13609409 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,10354985 0,13601636 ! body fluid secretion GO:0007589 27 17 0,000 0,10354985 0,13593873 ! stem cell differentiation GO:0048863 36 17 0,000 0,10354985 0,13586118 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,10354985 0,13578372 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,10354985 0,13570635 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,10354985 0,13562907 ! sensory perception of pain GO:0019233 23 17 0,000 0,10354985 0,13555188 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,10354985 0,13547477 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,10354985 0,13539776 ! synaptogenesis GO:0007416 24 17 0,000 0,10354985 0,13532082 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,10354985 0,13524398 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,10354985 0,13516723 ! cell-cell junction organization GO:0045216 25 17 0,000 0,10354985 0,13509056 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,10354985 0,13501397 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,10354985 0,13493748 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,10354985 0,13486107 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,10354985 0,13478475 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,1052158 0,13687576 ! nucleosome organization GO:0034728 114 87 1,000 0,10725887 0,13945471 ! female pregnancy GO:0007565 130 87 1,000 0,10725887 0,13937593 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,10929863 0,14194627 ! positive regulation of translation GO:0045727 28 18 0,000 0,10929863 0,14186616 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,10929863 0,14178615 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,10929863 0,14170622 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,10929863 0,14162639 ! cAMP metabolic process GO:0046058 33 18 0,000 0,10929863 0,14154665 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,10929863 0,14146699 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,10929863 0,14138743 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,10929863 0,14130795 ! axis specification GO:0009798 26 18 0,000 0,10929863 0,14122856 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,10929863 0,14114927 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,10929863 0,14107006 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,10929863 0,14099094 ! glutamine metabolic process GO:0006541 23 18 0,000 0,10929863 0,14091191 ! response to retinoic acid GO:0032526 25 18 0,000 0,10929863 0,14083296 ! pigmentation during development GO:0048066 31 18 0,000 0,10929863 0,14075411 ! central nervous system neuron development GO:0021954 30 18 0,000 0,10929863 0,14067535 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,10929863 0,14059667 ! fucose metabolic process GO:0006004 26 18 0,000 0,10929863 0,14051808 ! response to fungus GO:0009620 19 18 0,000 0,10929863 0,14043958 ! peptide cross-linking GO:0018149 31 18 0,000 0,10929863 0,14036116 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,10929863 0,14028284 ! heart process GO:0003015 27 18 0,000 0,10929863 0,1402046 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,10929863 0,14012645 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,10929863 0,14004838 ! visual learning GO:0008542 35 18 0,000 0,10929863 0,1399704 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,10929863 0,13989251 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,10929863 0,13981471 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,10929863 0,13973699 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,10929863 0,13965936 ! vitamin transport GO:0051180 24 18 0,000 0,10929863 0,13958181 ! hormone transport GO:0009914 27 18 0,000 0,10929863 0,13950435 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,10929863 0,13942698 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,10929863 0,13934969 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,10929863 0,13927249 ! cell-cell recognition GO:0009988 20 18 0,000 0,10929863 0,13919537 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,10929863 0,13911834 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,10929863 0,1390414 ! protein processing GO:0016485 114 88 1,000 0,10931261 0,13898232 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,11137683 0,14152857 ! regulation of T cell activation GO:0050863 128 89 1,000 0,11137683 0,14145042 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,11501087 0,1459851 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,11501087 0,14590457 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,11501087 0,14582414 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,11501087 0,1457438 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,11501087 0,14566354 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,11501087 0,14558338 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,11501087 0,1455033 ! sensory perception of taste GO:0050909 23 19 0,000 0,11501087 0,14542331 ! smooth muscle contraction GO:0006939 36 19 0,000 0,11501087 0,1453434 ! peroxisome organization GO:0007031 29 19 0,000 0,11501087 0,14526359 ! digestive system process GO:0022600 30 19 0,000 0,11501087 0,14518386 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,11501087 0,14510422 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,11501087 0,14502467 ! response to vitamin A GO:0033189 26 19 0,000 0,11501087 0,1449452 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,11501087 0,14486582 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,11501087 0,14478653 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,11501087 0,14470733 ! plasma membrane fusion GO:0045026 23 19 0,000 0,11501087 0,14462821 ! cytolysis GO:0019835 20 19 0,000 0,11501087 0,14454918 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,11501087 0,14447023 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,11501087 0,14439137 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,11501087 0,1443126 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,11501087 0,14423391 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,11501087 0,14415531 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,11501087 0,14407679 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,11501087 0,14399836 ! sarcomere organization GO:0045214 23 19 0,000 0,11501087 0,14392002 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,11501087 0,14384176 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,11501087 0,14376358 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,11501087 0,14368549 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,11501087 0,14360749 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,11501087 0,14352957 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,11501087 0,14345173 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,11501087 0,14337398 ! protein stabilization GO:0050821 26 19 0,000 0,11501087 0,14329631 ! response to virus GO:0009615 122 91 1,000 0,11553582 0,14387243 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,11763016 0,14640118 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,11763016 0,146322 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,11973413 0,14885864 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,1206868 0,14996199 ! iron ion transport GO:0006826 37 20 0,000 0,1206868 0,14988101 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,1206868 0,14980013 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,1206868 0,14971933 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,1206868 0,14963862 ! response to vitamin GO:0033273 29 20 0,000 0,1206868 0,14955799 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,1206868 0,14947746 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,1206868 0,149397 ! spinal cord development GO:0021510 31 20 0,000 0,1206868 0,14931664 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,1206868 0,14923636 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,1206868 0,14915617 ! chromosome condensation GO:0030261 31 20 0,000 0,1206868 0,14907607 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,1206868 0,14899605 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,1206868 0,14891611 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,1206868 0,14883627 ! DNA modification GO:0006304 28 20 0,000 0,1206868 0,1487565 ! collagen fibril organization GO:0030199 45 20 0,000 0,1206868 0,14867683 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,1206868 0,14859723 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,1206868 0,14851773 ! collagen catabolic process GO:0030574 25 20 0,000 0,1206868 0,14843831 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,1206868 0,14835897 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,1206868 0,14827972 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,1206868 0,14820055 ! alditol metabolic process GO:0019400 24 20 0,000 0,1206868 0,14812147 ! actin filament-based movement GO:0030048 34 20 0,000 0,1206868 0,14804247 ! carboxylic acid transport GO:0046942 147 95 1,000 0,1239701 0,15198892 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 1,000 0,1261017 0,15451993 ! protein maturation GO:0051604 129 96 1,000 0,1261017 0,15443765 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,12632665 0,15463081 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,12632665 0,15454856 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,12632665 0,1544664 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,12632665 0,15438432 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,12632665 0,15430233 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,12632665 0,15422043 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,12632665 0,15413862 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,12632665 0,15405689 ! vesicle docking GO:0048278 27 21 0,000 0,12632665 0,15397525 ! phototransduction GO:0007602 25 21 0,000 0,12632665 0,15389369 ! dendrite development GO:0016358 35 21 0,000 0,12632665 0,15381222 ! visual behavior GO:0007632 39 21 0,000 0,12632665 0,15373084 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,12632665 0,15364955 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,12632665 0,15356834 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,12632665 0,15348721 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,12632665 0,15340617 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,12632665 0,15332522 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,12632665 0,15324435 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,12632665 0,15316357 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,12632665 0,15308287 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,12632665 0,15300226 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,12632665 0,15292173 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,12632665 0,15284129 ! immunoglobulin production GO:0002377 33 21 0,000 0,12632665 0,15276093 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,12632665 0,15268066 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,12632665 0,15260047 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,12632665 0,15252036 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,12632665 0,15244034 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,12632665 0,1523604 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,12632665 0,15228055 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,12632665 0,15220078 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,12632665 0,1521211 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,12632665 0,15204149 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,12632665 0,15196197 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,13193065 0,15862022 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,13193065 0,15853735 ! viral genome replication GO:0019079 29 22 0,000 0,13193065 0,15845456 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,13193065 0,15837186 ! leukocyte adhesion GO:0007159 38 22 0,000 0,13193065 0,15828925 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,13193065 0,15820672 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,13193065 0,15812428 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,13193065 0,15804192 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,13193065 0,15795965 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,13193065 0,15787747 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,13193065 0,15779537 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,13193065 0,15771335 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,13193065 0,15763142 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,13193065 0,15754958 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,13193065 0,15746782 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,13193065 0,15738615 ! membrane depolarization GO:0051899 35 22 0,000 0,13193065 0,15730456 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,13193065 0,15722305 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,13193065 0,15714163 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,13193065 0,15706029 ! blastocyst development GO:0001824 37 22 0,000 0,13193065 0,15697904 ! extracellular structure organization GO:0043062 156 99 1,000 0,13254856 0,15763273 ! protein import GO:0017038 156 99 1,000 0,13254856 0,15755127 ! regulation of translation GO:0006417 151 100 1,000 0,13471423 0,16004273 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,13471423 0,1599601 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,13471423 0,15987756 ! protein localization in organelle GO:0033365 161 100 1,000 0,13471423 0,15979511 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,13749902 0,1630143 ! neuron fate commitment GO:0048663 32 23 0,000 0,13749902 0,16293032 ! embryonic pattern specification GO:0009880 31 23 0,000 0,13749902 0,16284642 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,13749902 0,16276261 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,13749902 0,16267888 ! vesicle targeting GO:0006903 32 23 0,000 0,13749902 0,16259524 ! osteoblast differentiation GO:0001649 40 23 0,000 0,13749902 0,16251169 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,13749902 0,16242822 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,13749902 0,16234484 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,13749902 0,16226154 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,13749902 0,16217833 ! cell fate determination GO:0001709 45 23 0,000 0,13749902 0,1620952 ! pentose metabolic process GO:0019321 31 23 0,000 0,13749902 0,16201216 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,13749902 0,16192921 ! spermatid development GO:0007286 33 23 0,000 0,13749902 0,16184634 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,13749902 0,16176355 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,13749902 0,16168085 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,13749902 0,16159823 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,13749902 0,1615157 ! telomere organization GO:0032200 32 23 0,000 0,13749902 0,16143325 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,13749902 0,16135089 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,13749902 0,16126861 ! regulation of amine transport GO:0051952 38 23 0,000 0,13749902 0,16118641 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,14303199 0,16758715 ! initiation of viral infection GO:0019059 42 24 0,000 0,14303199 0,16750182 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,14303199 0,16741658 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,14303199 0,16733142 ! superoxide metabolic process GO:0006801 32 24 0,000 0,14303199 0,16724635 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,14303199 0,16716137 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,14303199 0,16707647 ! sperm motility GO:0030317 27 24 0,000 0,14303199 0,16699166 ! vacuole organization GO:0007033 39 24 0,000 0,14303199 0,16690694 ! neural crest cell development GO:0014032 39 24 0,000 0,14303199 0,1668223 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,14303199 0,16673775 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,14303199 0,16665328 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,14303199 0,1665689 ! glutathione metabolic process GO:0006749 29 24 0,000 0,14303199 0,1664846 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,14303199 0,16640039 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,14852978 0,17270904 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,14852978 0,17262177 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,14852978 0,17253459 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,14852978 0,1724475 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,14852978 0,17236049 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,14852978 0,17227357 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,14852978 0,17218674 ! peptide transport GO:0015833 43 25 0,000 0,14852978 0,17209999 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,14852978 0,17201334 ! phospholipid transport GO:0015914 35 25 0,000 0,14852978 0,17192677 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,14852978 0,17184029 ! detection of light stimulus GO:0009583 30 25 0,000 0,14852978 0,17175389 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,15399261 0,17798141 ! translational initiation GO:0006413 43 26 0,000 0,15399261 0,17789202 ! circadian rhythm GO:0007623 42 26 0,000 0,15399261 0,17780271 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,15399261 0,1777135 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,15399261 0,17762438 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,15399261 0,17753534 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,15399261 0,17744639 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,15399261 0,17735754 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,15399261 0,17726877 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,15399261 0,17718009 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,15399261 0,1770915 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,15942071 0,18324219 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,15942071 0,18315066 ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,15942071 0,18305922 ! membrane docking GO:0022406 39 27 0,000 0,15942071 0,18296788 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,15942071 0,18287662 ! catechol metabolic process GO:0009712 43 27 0,000 0,15942071 0,18278545 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,15942071 0,18269438 ! acute-phase response GO:0006953 42 27 0,000 0,15942071 0,1826034 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,15942071 0,1825125 ! myofibril assembly GO:0030239 36 27 0,000 0,15942071 0,1824217 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,15942071 0,18233099 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,15942071 0,18224037 ! natural killer cell activation GO:0030101 35 27 0,000 0,15942071 0,18214984 ! lipid oxidation GO:0034440 38 27 0,000 0,15942071 0,1820594 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,15942071 0,18196904 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,15942071 0,18187878 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,15942071 0,18178861 ! gene silencing GO:0016458 41 27 0,000 0,15942071 0,18169852 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,16481428 0,18775277 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,16481428 0,18765983 ! phenol metabolic process GO:0018958 44 28 0,000 0,16481428 0,18756697 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,16481428 0,18747421 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,16481428 0,18738154 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,16481428 0,18728896 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,16481428 0,18719647 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,16481428 0,18710407 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,16481428 0,18701177 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,16481428 0,18691955 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,16481428 0,18682743 ! mesoderm formation GO:0001707 46 28 0,000 0,16481428 0,18673539 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,16481428 0,18664345 ! BMP signaling pathway GO:0030509 40 28 0,000 0,16481428 0,1865516 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,16481428 0,18645984 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,16481428 0,18636817 ! regulation of innate immune response GO:0045088 38 29 0,000 0,17017356 0,19233375 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,17017356 0,19223928 ! protein targeting to membrane GO:0006612 53 29 0,000 0,17017356 0,19214491 ! mismatch repair GO:0006298 34 29 0,000 0,17017356 0,19205063 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,17017356 0,19195644 ! muscle cell development GO:0055001 38 29 0,000 0,17017356 0,19186234 ! formation of primary germ layer GO:0001704 48 29 0,000 0,17017356 0,19176834 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,17017356 0,19167443 ! eye morphogenesis GO:0048592 51 29 0,000 0,17017356 0,19158061 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,17549875 0,19747902 ! collagen metabolic process GO:0032963 40 30 0,000 0,17549875 0,19738246 ! organic anion transport GO:0015711 51 30 0,000 0,17549875 0,19728598 ! cholesterol transport GO:0030301 46 30 0,000 0,17549875 0,19718961 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,17549875 0,19709332 ! spliceosome assembly GO:0000245 49 30 0,000 0,17549875 0,19699713 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,17549875 0,19690104 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,17549875 0,19680503 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,17549875 0,19670912 ! ceramide metabolic process GO:0006672 43 30 0,000 0,17549875 0,19661331 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,17549875 0,19651759 ! adult locomotory behavior GO:0008344 47 30 0,000 0,17549875 0,19642196 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,17549875 0,19632642 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,17549875 0,19623098 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,17549875 0,19613563 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,18079007 0,20195103 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,18079007 0,20185299 ! odontogenesis GO:0042476 50 31 0,000 0,18079007 0,20175505 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,18079007 0,20165721 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,18079007 0,20155946 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,18079007 0,2014618 ! cell fate specification GO:0001708 37 31 0,000 0,18079007 0,20136424 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,18079007 0,20126678 ! RNA modification GO:0009451 40 31 0,000 0,18079007 0,20116941 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,18604774 0,20691963 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,18604774 0,20681962 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,18604774 0,20671971 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,18604774 0,20661989 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,18604774 0,20652017 ! vesicle localization GO:0051648 47 32 0,000 0,18604774 0,20642055 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,19127196 0,21211451 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,19127196 0,21201229 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,19127196 0,21191016 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,19127196 0,21180814 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,19127196 0,21170621 ! actomyosin structure organization GO:0031032 43 33 0,000 0,19127196 0,21160438 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,19127196 0,21150264 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,19127196 0,21140101 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,19127196 0,21129947 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,19127196 0,21119803 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,19127196 0,21109669 ! regulation of proteolysis GO:0030162 50 33 0,000 0,19127196 0,21099544 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,19127196 0,2108943 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,19127196 0,21079324 ! mRNA catabolic process GO:0006402 48 34 0,000 0,19646294 0,21641033 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,19646294 0,21630674 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,19646294 0,21620324 ! feeding behavior GO:0007631 45 34 0,000 0,19646294 0,21609984 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,19646294 0,21599654 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,19646294 0,21589334 ! aerobic respiration GO:0009060 47 34 0,000 0,19646294 0,21579024 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,19646294 0,21568724 ! embryonic organ development GO:0048568 45 34 0,000 0,19646294 0,21558434 ! Notch signaling pathway GO:0007219 56 35 0,000 0,20162091 0,22113881 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,20162091 0,22103341 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,20162091 0,2209281 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,20162091 0,2208229 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,20162091 0,22071779 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,20162091 0,22061279 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,20162091 0,22050789 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,20162091 0,22040308 ! glycogen metabolic process GO:0005977 48 35 0,000 0,20162091 0,22029838 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,20674606 0,22579104 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,20674606 0,22568388 ! glucan metabolic process GO:0044042 49 36 0,000 0,20674606 0,22557682 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,21183859 0,2310236 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,21183859 0,23091411 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,21183859 0,23080472 ! learning GO:0007612 67 37 0,000 0,21183859 0,23069544 ! ion transmembrane transport GO:0034220 56 37 0,000 0,21183859 0,23058626 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,21183859 0,23047718 ! amino acid activation GO:0043038 52 37 0,000 0,21183859 0,23036821 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,21183859 0,23025934 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,21689873 0,23564813 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,21689873 0,23553687 ! phagocytosis GO:0006909 60 38 0,000 0,21689873 0,23542571 ! maintenance of location in cell GO:0051651 69 38 0,000 0,21689873 0,23531466 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,22192667 0,24065598 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,22192667 0,24054257 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,22192667 0,24042927 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,22192667 0,24031607 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,22192667 0,24020298 ! chromatin remodeling GO:0006338 68 39 0,000 0,22192667 0,24009 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,22192667 0,23997712 ! cell growth GO:0016049 61 39 0,000 0,22192667 0,23986435 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,22692261 0,2451489 ! response to calcium ion GO:0051592 58 40 0,000 0,22692261 0,2450338 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,22692261 0,24491882 ! peptide metabolic process GO:0006518 56 40 0,000 0,22692261 0,24480394 ! inner ear development GO:0048839 57 40 0,000 0,22692261 0,24468917 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,22692261 0,24457451 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,22692261 0,24445996 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,22692261 0,24434551 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,22692261 0,24423117 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,23188676 0,24945722 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,23188676 0,2493406 ! striated muscle contraction GO:0006941 62 41 0,000 0,23188676 0,24922409 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,23188676 0,24910768 ! biopolymer methylation GO:0043414 62 41 0,000 0,23188676 0,24899138 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,23681931 0,25416912 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,23681931 0,25405057 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,23681931 0,25393213 ! excretion GO:0007588 63 42 0,000 0,23681931 0,2538138 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,23681931 0,25369558 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,23681931 0,25357748 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,23681931 0,25345948 ! neuromuscular process GO:0050905 79 43 0,000 0,24172047 0,25858469 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,24172047 0,25846448 ! tRNA processing GO:0008033 49 43 0,000 0,24172047 0,25834437 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,24172047 0,25822438 ! methylation GO:0032259 64 43 0,000 0,24172047 0,2581045 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,24659044 0,26318237 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,24659044 0,2630603 ! RNA catabolic process GO:0006401 64 45 0,000 0,2514294 0,26809811 ! regulation of translational initiation GO:0006446 64 45 0,000 0,2514294 0,26797388 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,2514294 0,26784976 ! cell recognition GO:0008037 58 45 0,000 0,2514294 0,26772575 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,25623756 0,2727193 ! cell redox homeostasis GO:0045454 63 46 0,000 0,25623756 0,27259315 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,25623756 0,27246713 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,25623756 0,27234122 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,26101512 0,27729088 ! viral infectious cycle GO:0019058 71 47 0,000 0,26101512 0,27716287 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,26101512 0,27703496 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,26101512 0,27690718 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,26101512 0,27677951 ! chloride transport GO:0006821 67 48 0,000 0,26576225 0,28168349 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,26576225 0,28155374 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,26576225 0,28142411 ! gastrulation GO:0007369 73 48 0,000 0,26576225 0,28129461 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,26576225 0,28116521 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,26576225 0,28103594 ! regulation of endocytosis GO:0030100 63 48 0,000 0,26576225 0,28090679 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,26576225 0,28077776 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,27047916 0,28562997 ! sensory perception of smell GO:0007608 61 49 0,000 0,27047916 0,28549889 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,27047916 0,28536792 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,27047916 0,28523708 ! RNA elongation GO:0006354 62 49 0,000 0,27047916 0,28510636 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,27047916 0,28497575 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,27047916 0,28484527 ! maintenance of location GO:0051235 84 49 0,000 0,27047916 0,28471491 ! regulation of actin filament length GO:0030832 72 50 0,000 0,27516604 0,28951596 ! membrane fusion GO:0006944 80 50 0,000 0,27516604 0,28938358 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,27516604 0,28925132 ! proton transport GO:0015992 75 50 0,000 0,27516604 0,28911918 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,27516604 0,28898716 ! hydrogen transport GO:0006818 77 51 0,000 0,27982307 0,29374398 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,27982307 0,29360998 ! adult behavior GO:0030534 80 51 0,000 0,27982307 0,29347609 ! transition metal ion transport GO:0000041 74 52 0,000 0,28445045 0,29819327 ! regulation of cellular component size GO:0032535 74 52 0,000 0,28445045 0,29805742 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,28445045 0,29792169 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,28904836 0,30259956 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,28904836 0,30246189 ! single fertilization GO:0007338 59 53 0,000 0,28904836 0,30232434 ! amino acid transport GO:0006865 84 54 0,000 0,29361698 0,30696321 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,29361698 0,30682375 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,29361698 0,30668441 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,29361698 0,3065452 ! mesoderm development GO:0007498 76 55 0,000 0,29815651 0,31114337 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,29815651 0,31100226 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,29815651 0,31086128 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,30714901 0,32009185 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,30714901 0,31994688 ! camera-type eye development GO:0043010 88 57 0,000 0,30714901 0,31980205 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,31160234 0,32429203 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,31160234 0,32414536 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,3160273 0,32859982 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,32042407 0,33302095 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,32042407 0,33287054 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,32042407 0,33272026 ! fertilization GO:0009566 68 60 0,000 0,32042407 0,33257011 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,32479283 0,33695242 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,32479283 0,3368005 ! extracellular matrix organization GO:0030198 103 61 0,000 0,32479283 0,33664872 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,32479283 0,33649708 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,32479283 0,33634557 ! amine catabolic process GO:0009310 90 62 0,000 0,32913375 0,3406875 ! neurotransmitter transport GO:0006836 81 62 0,000 0,32913375 0,34053425 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,32913375 0,34038113 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,32913375 0,34022815 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,32913375 0,34007531 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,33773279 0,34880351 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,33773279 0,34864696 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,34199126 0,35288465 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,34199126 0,35272641 ! defense response to bacterium GO:0042742 73 65 0,000 0,34199126 0,35256831 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,34199126 0,35241035 ! activation of immune response GO:0002253 83 65 0,000 0,34199126 0,35225253 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,34622258 0,35645118 ! antigen processing and presentation GO:0019882 96 66 0,000 0,34622258 0,35629169 ! regulation of immune effector process GO:0002697 101 66 0,000 0,34622258 0,35613235 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,35042694 0,36029591 ! acute inflammatory response GO:0002526 92 68 0,000 0,3546045 0,36442821 ! learning or memory GO:0007611 123 68 0,000 0,3546045 0,36426545 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,3546045 0,36410283 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,3546045 0,36394036 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,3546045 0,36377803 ! inorganic anion transport GO:0015698 93 68 0,000 0,3546045 0,36361585 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,35875543 0,36770832 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,35875543 0,36754453 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,3628799 0,37160452 ! eye development GO:0001654 111 70 0,000 0,3628799 0,37143915 ! amine transport GO:0015837 101 70 0,000 0,3628799 0,37127392 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,3628799 0,37110883 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,36697807 0,37513314 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,36697807 0,37496649 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,36697807 0,37479999 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,37105012 0,37879063 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,37509621 0,38275123 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,3791165 0,38668202 ! digestion GO:0007586 97 74 0,000 0,3791165 0,38651062 ! regulation of ligase activity GO:0051340 114 75 0,000 0,38311115 0,39041013 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,38311115 0,39023723 ! tRNA metabolic process GO:0006399 95 76 0,000 0,38708034 0,3941057 ! response to unfolded protein GO:0006986 99 76 0,000 0,38708034 0,39393132 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,39102421 0,39776899 ! protein ubiquitination GO:0016567 125 77 0,000 0,39102421 0,39759314 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,39102421 0,39741744 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,39102421 0,39724191 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,39102421 0,39706652 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,39494292 0,40086881 ! cellular respiration GO:0045333 107 79 0,000 0,39883665 0,40464239 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,39883665 0,40446397 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,39883665 0,40428572 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,40270554 0,40802764 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,40270554 0,40784797 ! mRNA transport GO:0051028 121 81 0,000 0,40654975 0,41156005 ! vitamin metabolic process GO:0006766 103 81 0,000 0,40654975 0,41137898 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,41416477 0,41890016 ! sterol metabolic process GO:0016125 120 84 0,000 0,41793588 0,42252858 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,42168293 0,42612949 ! rRNA metabolic process GO:0016072 107 85 0,000 0,42168293 0,42594235 GO:0006364|rRNA processing, ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,42910545 0,43324958 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,42910545 0,43305948 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,43278123 0,43657756 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,43278123 0,43638616 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,43278123 0,43619493 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,43643356 0,43968339 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,44006257 0,44314532 ! RNA localization GO:0006403 135 91 0,000 0,44366842 0,44658091 ! ATP metabolic process GO:0046034 137 91 0,000 0,44366842 0,44638555 ! positive regulation of immune response GO:0050778 121 92 0,000 0,44725126 0,44979357 ! sulfur metabolic process GO:0006790 118 92 0,000 0,44725126 0,44959699 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,45081123 0,45297765 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,45081123 0,45277984 ! electron transport chain GO:0022900 123 94 0,000 0,45434848 0,45613334 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,46135536 0,46296568 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,46135536 0,46276378 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,46135536 0,46256205 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,46482529 0,46583799 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,46482529 0,46563509 ! calcium ion transport GO:0006816 167 99 0,000 0,47169883 0,47231489 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,47510271 0,47551621 ! divalent metal ion transport GO:0070838 171 100 0,000 0,47510271 0,47530937 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,47510271 0,47510271