pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6558-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! cell cycle checkpoint GO:0000075 42 41 5,000 2,745E-07 5,06E-04 ! positive regulation of MAP kinase activity GO:0043406 50 49 5,000 8,195E-07 7,551E-04 ! interphase of mitotic cell cycle GO:0051329 52 51 5,000 1,045E-06 6,417E-04 GO:0051325|interphase, ! positive regulation of protein kinase activity GO:0045860 89 86 6,000 1,563E-06 7,202E-04 ! positive regulation of transferase activity GO:0051347 91 88 6,000 1,828E-06 6,738E-04 GO:0033674|positive regulation of kinase activity, ! negative regulation of cell growth GO:0030308 32 32 4,000 2,098E-06 6,445E-04 ! negative regulation of cell size GO:0045792 33 33 4,000 2,46E-06 6,478E-04 ! response to peptide hormone stimulus GO:0043434 36 34 4,000 2,87E-06 6,611E-04 ! T cell lineage commitment GO:0002360 5 5 2,000 2,96E-06 6,062E-04 ! positive regulation of cell migration GO:0030335 36 36 4,000 3,849E-06 7,093E-04 ! response to hormone stimulus GO:0009725 102 100 6,000 4,334E-06 7,262E-04 ! negative regulation of growth GO:0045926 37 37 4,000 4,427E-06 6,8E-04 ! regulation of MAP kinase activity GO:0043405 67 66 5,000 4,88E-06 6,918E-04 ! positive regulation of cell motion GO:0051272 39 39 4,000 5,789E-06 7,62E-04 ! focal adhesion formation GO:0048041 7 6 2,000 5,892E-06 7,239E-04 ! DNA damage checkpoint GO:0000077 19 19 3,000 6,875E-06 7,919E-04 ! regulation of cell migration GO:0030334 71 71 5,000 7,497E-06 8,128E-04 ! response to gamma radiation GO:0010332 8 7 2,000 1,026E-05 1,051E-03 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 3,000 1,051E-05 1,019E-03 ! DNA integrity checkpoint GO:0031570 21 21 3,000 1,051E-05 9,685E-04 ! cellular response to insulin stimulus GO:0032869 23 21 3,000 1,051E-05 9,224E-04 ! cellular response to hormone stimulus GO:0032870 48 46 4,000 1,33E-05 1,114E-03 ! regulation of locomotion GO:0040012 79 79 5,000 1,397E-05 1,119E-03 ! regulation of cell motion GO:0051270 79 79 5,000 1,397E-05 1,072E-03 ! negative regulation of bone remodeling GO:0046851 8 8 2,000 1,634E-05 1,205E-03 ! negative regulation of blood coagulation GO:0030195 9 8 2,000 1,634E-05 1,158E-03 ! release of cytochrome c from mitochondria GO:0001836 9 8 2,000 1,634E-05 1,115E-03 ! glucose homeostasis GO:0042593 24 24 3,000 1,838E-05 1,21E-03 GO:0033500|carbohydrate homeostasis, ! negative regulation of tissue remodeling GO:0034104 9 9 2,000 2,439E-05 1,55E-03 ! response to insulin stimulus GO:0032868 28 26 3,000 2,56E-05 1,573E-03 ! response to hypoxia GO:0001666 53 53 4,000 2,686E-05 1,597E-03 ! response to oxygen levels GO:0070482 55 54 4,000 2,946E-05 1,696E-03 ! negative regulation of multicellular organismal process GO:0051241 55 54 4,000 2,946E-05 1,645E-03 ! apoptotic mitochondrial changes GO:0008637 11 10 2,000 3,468E-05 1,88E-03 ! cell-substrate junction assembly GO:0007044 11 10 2,000 3,468E-05 1,826E-03 ! negative regulation of homeostatic process GO:0032845 10 10 2,000 3,468E-05 1,775E-03 ! negative regulation of coagulation GO:0050819 11 10 2,000 3,468E-05 1,727E-03 ! protein amino acid autophosphorylation GO:0046777 28 28 3,000 3,472E-05 1,684E-03 ! regulation of epithelial cell proliferation GO:0050678 29 29 3,000 4,007E-05 1,894E-03 ! response to UV GO:0009411 29 29 3,000 4,007E-05 1,846E-03 ! regulation of cell growth GO:0001558 97 96 5,000 4,269E-05 1,919E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 2,000 4,745E-05 2,082E-03 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 5,000 5,377E-05 2,305E-03 ! hemopoiesis GO:0030097 104 100 5,000 5,377E-05 2,252E-03 ! G1 phase GO:0051318 13 12 2,000 6,297E-05 2,579E-03 ! regulation of response to external stimulus GO:0032101 65 64 4,000 6,749E-05 2,704E-03 ! regulation of bone remodeling GO:0046850 34 34 3,000 7,631E-05 2,992E-03 ! mitochondrial membrane organization GO:0007006 13 13 2,000 8,147E-05 3,128E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 2,000 8,147E-05 3,064E-03 ! response to corticosteroid stimulus GO:0031960 13 13 2,000 8,147E-05 3,003E-03 GO:0051384|response to glucocorticoid stimulus, ! cell aging GO:0007569 13 13 2,000 8,147E-05 2,944E-03 ! regulation of cell-substrate adhesion GO:0010810 14 13 2,000 8,147E-05 2,887E-03 GO:0001952|regulation of cell-matrix adhesion, ! protein tetramerization GO:0051262 13 13 2,000 8,147E-05 2,833E-03 ! regulation of tissue remodeling GO:0034103 35 35 3,000 8,573E-05 2,926E-03 ! regulation of cell size GO:0008361 68 68 4,000 9,04E-05 3,029E-03 ! coagulation GO:0050817 39 36 3,000 9,596E-05 3,158E-03 GO:0007596|blood coagulation, ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 1,032E-04 3,336E-03 ! regulation of blood coagulation GO:0030193 15 14 2,000 1,032E-04 3,279E-03 ! wound healing GO:0042060 74 70 4,000 1,039E-04 3,246E-03 ! meiosis GO:0007126 37 37 3,000 1,071E-04 3,288E-03 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of protein kinase activity GO:0006469 37 37 3,000 1,071E-04 3,234E-03 ! response to drug GO:0042493 37 37 3,000 1,071E-04 3,182E-03 ! DNA damage response, signal transduction GO:0042770 37 37 3,000 1,071E-04 3,132E-03 ! negative regulation of kinase activity GO:0033673 38 38 3,000 1,191E-04 3,428E-03 ! meiotic cell cycle GO:0051321 38 38 3,000 1,191E-04 3,376E-03 ! regulation of homeostatic process GO:0032844 38 38 3,000 1,191E-04 3,324E-03 ! insulin receptor signaling pathway GO:0008286 17 15 2,000 1,284E-04 3,531E-03 ! response to ionizing radiation GO:0010212 16 15 2,000 1,284E-04 3,479E-03 ! hemostasis GO:0007599 42 39 3,000 1,32E-04 3,526E-03 ! activation of MAPK activity GO:0000187 39 39 3,000 1,32E-04 3,475E-03 ! protein oligomerization GO:0051259 39 39 3,000 1,32E-04 3,426E-03 ! negative regulation of transferase activity GO:0051348 40 40 3,000 1,459E-04 3,736E-03 ! regulation of coagulation GO:0050818 17 16 2,000 1,572E-04 3,97E-03 ! cell morphogenesis involved in differentiation GO:0000904 82 77 4,000 1,637E-04 4,076E-03 ! cell-substrate adhesion GO:0031589 43 42 3,000 1,77E-04 4,348E-03 ! regulation of fibroblast proliferation GO:0048145 17 17 2,000 1,9E-04 4,608E-03 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 2,000 1,9E-04 4,548E-03 ! positive regulation of cell adhesion GO:0045785 17 17 2,000 1,9E-04 4,49E-03 ! cell junction assembly GO:0034329 18 17 2,000 1,9E-04 4,433E-03 ! response to toxin GO:0009636 18 17 2,000 1,9E-04 4,378E-03 ! MAPKKK cascade GO:0000165 82 81 4,000 2,08E-04 4,732E-03 ! meiosis I GO:0007127 18 18 2,000 2,269E-04 5,1E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 2,000 2,269E-04 5,039E-03 ! B cell differentiation GO:0030183 18 18 2,000 2,269E-04 4,979E-03 ! placenta development GO:0001890 19 19 2,000 2,682E-04 5,815E-03 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 4,000 2,756E-04 5,906E-03 ! leukocyte differentiation GO:0002521 50 49 3,000 3,235E-04 6,852E-03 ! negative regulation of cell cycle GO:0045786 92 91 4,000 3,587E-04 7,513E-03 ! regulation of multicellular organism growth GO:0040014 21 21 2,000 3,646E-04 7,55E-03 ! cell fate commitment GO:0045165 52 52 3,000 4,071E-04 8,337E-03 ! regulation of body fluid levels GO:0050878 55 52 3,000 4,071E-04 8,246E-03 ! response to light stimulus GO:0009416 53 52 3,000 4,071E-04 8,156E-03 ! regulation of response to stress GO:0080134 97 94 4,000 4,17E-04 8,264E-03 ! cell junction organization GO:0034330 23 22 2,000 4,201E-04 8,237E-03 ! positive regulation of glucose metabolic process GO:0010907 5 5 1,000 4,509E-04 8,747E-03 ! metencephalon development GO:0022037 5 5 1,000 4,509E-04 8,656E-03 ! mRNA stabilization GO:0048255 5 5 1,000 4,509E-04 8,566E-03 GO:0043489|RNA stabilization, ! response to lipid GO:0033993 5 5 1,000 4,509E-04 8,479E-03 ! endocrine pancreas development GO:0031018 5 5 1,000 4,509E-04 8,393E-03 ! muscle cell migration GO:0014812 5 5 1,000 4,509E-04 8,309E-03 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 4,509E-04 8,227E-03 ! fear response GO:0042596 5 5 1,000 4,509E-04 8,147E-03 ! protein heterooligomerization GO:0051291 5 5 1,000 4,509E-04 8,067E-03 ! response to UV-B GO:0010224 5 5 1,000 4,509E-04 7,99E-03 ! enucleate erythrocyte differentiation GO:0043353 6 5 1,000 4,509E-04 7,914E-03 ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 4,509E-04 7,839E-03 ! cellular pigmentation GO:0033059 5 5 1,000 4,509E-04 7,766E-03 ! peptidyl-lysine modification GO:0018205 5 5 1,000 4,509E-04 7,694E-03 ! negative regulation of neuroblast proliferation GO:0007406 5 5 1,000 4,509E-04 7,623E-03 ! oocyte differentiation GO:0009994 5 5 1,000 4,509E-04 7,554E-03 GO:0048599|oocyte development, ! regulation of protein homodimerization activity GO:0043496 6 5 1,000 4,509E-04 7,486E-03 ! spleen development GO:0048536 5 5 1,000 4,509E-04 7,419E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 1,000 4,509E-04 7,354E-03 ! response to nicotine GO:0035094 5 5 1,000 4,509E-04 7,289E-03 ! positive regulation of growth GO:0045927 23 23 2,000 4,809E-04 7,706E-03 ! lipid homeostasis GO:0055088 23 23 2,000 4,809E-04 7,64E-03 ! regulation of cell adhesion GO:0030155 56 55 3,000 5,053E-04 7,959E-03 ! mitochondrial transport GO:0006839 24 24 2,000 5,469E-04 8,542E-03 ! T cell differentiation GO:0030217 24 24 2,000 5,469E-04 8,47E-03 ! androgen receptor signaling pathway GO:0030521 24 24 2,000 5,469E-04 8,4E-03 ! regulation of gene-specific transcription GO:0032583 25 25 2,000 6,185E-04 9,421E-03 ! peptidyl-amino acid modification GO:0018193 61 59 3,000 6,61E-04 9,985E-03 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 6,734E-04 0,01008939 GO:0018409|peptide or protein amino-terminal blocking, ! virus-host interaction GO:0019048 6 6 1,000 6,734E-04 0,01000802 ! regulation of lipid kinase activity GO:0043550 6 6 1,000 6,734E-04 9,928E-03 ! regulation of positive chemotaxis GO:0050926 6 6 1,000 6,734E-04 9,849E-03 GO:0050927|positive regulation of positive chemotaxis, ! nerve growth factor receptor signaling pathway GO:0048011 6 6 1,000 6,734E-04 9,772E-03 ! L-serine metabolic process GO:0006563 6 6 1,000 6,734E-04 9,695E-03 ! ER overload response GO:0006983 6 6 1,000 6,734E-04 9,62E-03 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 6,734E-04 9,546E-03 GO:0070667|negative regulation of mast cell proliferation, ! regulation of vascular permeability GO:0043114 6 6 1,000 6,734E-04 9,473E-03 ! peptidyl-serine phosphorylation GO:0018105 6 6 1,000 6,734E-04 9,401E-03 ! negative regulation of ossification GO:0030279 6 6 1,000 6,734E-04 9,331E-03 ! regulation of bone resorption GO:0045124 6 6 1,000 6,734E-04 9,261E-03 ! G1 DNA damage checkpoint GO:0031571 6 6 1,000 6,734E-04 9,193E-03 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 6,734E-04 9,125E-03 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 6,734E-04 9,058E-03 ! nitric oxide metabolic process GO:0046209 6 6 1,000 6,734E-04 8,993E-03 GO:0006809|nitric oxide biosynthetic process, ! serine family amino acid biosynthetic process GO:0009070 6 6 1,000 6,734E-04 8,928E-03 ! thymus development GO:0048538 6 6 1,000 6,734E-04 8,864E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 1,000 6,734E-04 8,801E-03 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! regulation of embryonic development GO:0045995 6 6 1,000 6,734E-04 8,739E-03 ! localization within membrane GO:0051668 6 6 1,000 6,734E-04 8,678E-03 ! negative regulation of cell migration GO:0030336 26 26 2,000 6,959E-04 8,906E-03 ! double-strand break repair GO:0006302 27 26 2,000 6,959E-04 8,845E-03 ! mesenchymal cell development GO:0014031 29 27 2,000 7,791E-04 9,835E-03 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! axonogenesis GO:0007409 66 62 3,000 7,981E-04 0,01000631 ! positive regulation of cellular catabolic process GO:0031331 7 7 1,000 9,386E-04 0,01168802 ! double-strand break repair via homologous recombination GO:0000724 7 7 1,000 9,386E-04 0,01160958 GO:0000725|recombinational repair, ! hair follicle morphogenesis GO:0031069 7 7 1,000 9,386E-04 0,01153218 ! digestive system development GO:0055123 7 7 1,000 9,386E-04 0,01145581 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! regulation of skeletal muscle fiber development GO:0048742 7 7 1,000 9,386E-04 0,01138045 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 9,386E-04 0,01130606 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! response to X-ray GO:0010165 7 7 1,000 9,386E-04 0,01123265 ! regulation of intracellular pH GO:0051453 7 7 1,000 9,386E-04 0,01116018 ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 1,000 9,386E-04 0,01108864 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! alpha-beta T cell differentiation GO:0046632 7 7 1,000 9,386E-04 0,01101801 ! platelet activation GO:0030168 8 7 1,000 9,386E-04 0,01094828 ! synaptic transmission, cholinergic GO:0007271 7 7 1,000 9,386E-04 0,01087942 ! regulation of macrophage differentiation GO:0045649 8 7 1,000 9,386E-04 0,01081142 ! regulation of mRNA stability GO:0043488 7 7 1,000 9,386E-04 0,01074427 ! negative regulation of T cell activation GO:0050868 7 7 1,000 9,386E-04 0,01067795 ! positive regulation of cell cycle GO:0045787 29 29 2,000 9,64E-04 0,0109 ! positive regulation of response to external stimulus GO:0032103 30 30 2,000 1,066E-03 0,01197982 ! regulation of ossification GO:0030278 30 30 2,000 1,066E-03 0,01190721 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 3,000 1,07E-03 0,01187529 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! striated muscle tissue development GO:0014706 69 67 3,000 1,07E-03 0,01180418 ! response to radiation GO:0009314 70 68 3,000 1,131E-03 0,0124053 ! B cell activation GO:0042113 31 31 2,000 1,175E-03 0,01280955 ! aging GO:0007568 32 31 2,000 1,175E-03 0,0127342 ! regulation of DNA replication GO:0006275 32 31 2,000 1,175E-03 0,01265973 ! regulation of myeloid cell differentiation GO:0045637 32 31 2,000 1,175E-03 0,01258613 ! negative regulation of cell motion GO:0051271 31 31 2,000 1,175E-03 0,01251338 ! response to nutrient levels GO:0031667 69 69 3,000 1,194E-03 0,0126514 ! regulation of mitotic cell cycle GO:0007346 72 69 3,000 1,194E-03 0,01257911 ! regulation of skeletal muscle tissue development GO:0048641 8 8 1,000 1,246E-03 0,01304772 ! pancreas development GO:0031016 8 8 1,000 1,246E-03 0,01297401 ! T cell selection GO:0045058 8 8 1,000 1,246E-03 0,01290112 ! positive regulation of endothelial cell migration GO:0010595 8 8 1,000 1,246E-03 0,01282904 ! sex determination GO:0007530 8 8 1,000 1,246E-03 0,01275777 ! negative regulation of mitotic cell cycle GO:0045930 9 8 1,000 1,246E-03 0,01268729 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 1,000 1,246E-03 0,01261758 ! alpha-beta T cell activation GO:0046631 8 8 1,000 1,246E-03 0,01254863 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 1,000 1,246E-03 0,01248043 ! T cell homeostasis GO:0043029 8 8 1,000 1,246E-03 0,01241297 ! peptidyl-serine modification GO:0018209 8 8 1,000 1,246E-03 0,01234623 ! positive regulation of leukocyte migration GO:0002687 8 8 1,000 1,246E-03 0,01228021 ! regulation of RNA stability GO:0043487 8 8 1,000 1,246E-03 0,01221489 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 1,000 1,246E-03 0,01215026 ! cell part morphogenesis GO:0032990 75 70 3,000 1,261E-03 0,01222713 ! muscle tissue development GO:0060537 72 70 3,000 1,261E-03 0,01216311 ! response to extracellular stimulus GO:0009991 72 72 3,000 1,4E-03 0,01344177 ! regulation of neuron apoptosis GO:0043523 34 33 2,000 1,412E-03 0,01348513 ! regulation of angiogenesis GO:0045765 35 34 2,000 1,541E-03 0,01464375 ! negative regulation of cell cycle process GO:0010948 9 9 1,000 1,595E-03 0,01507523 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 1,595E-03 0,01499831 ! response to alkaloid GO:0043279 10 9 1,000 1,595E-03 0,01492218 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 1,000 1,595E-03 0,01484681 ! response to ethanol GO:0045471 9 9 1,000 1,595E-03 0,01477221 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 1,000 1,595E-03 0,01469834 ! activation of pro-apoptotic gene products GO:0008633 9 9 1,000 1,595E-03 0,01462522 ! response to osmotic stress GO:0006970 9 9 1,000 1,595E-03 0,01455282 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 1,595E-03 0,01448113 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 9 9 1,000 1,595E-03 0,01441014 ! regulation of cellular pH GO:0030641 9 9 1,000 1,595E-03 0,01433985 ! histone acetylation GO:0016573 9 9 1,000 1,595E-03 0,01427024 ! regulation of leukocyte migration GO:0002685 9 9 1,000 1,595E-03 0,0142013 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 1,000 1,595E-03 0,01413302 ! defense response to virus GO:0051607 9 9 1,000 1,595E-03 0,0140654 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 2,000 1,678E-03 0,01472576 ! multicellular organism reproduction GO:0032504 36 35 2,000 1,678E-03 0,01465597 GO:0048609|reproductive process in a multicellular organism, ! response to steroid hormone stimulus GO:0048545 35 35 2,000 1,678E-03 0,01458684 ! lung development GO:0030324 38 37 2,000 1,973E-03 0,01707182 ! regulation of glucose metabolic process GO:0010906 10 10 1,000 1,985E-03 0,0170963 ! reciprocal meiotic recombination GO:0007131 10 10 1,000 1,985E-03 0,01701678 ! inositol metabolic process GO:0006020 10 10 1,000 1,985E-03 0,016938 ! fat cell differentiation GO:0045444 10 10 1,000 1,985E-03 0,01685994 ! epidermis morphogenesis GO:0048730 10 10 1,000 1,985E-03 0,01678261 ! neuromuscular junction development GO:0007528 10 10 1,000 1,985E-03 0,01670597 ! regulation of protein binding GO:0043393 11 10 1,000 1,985E-03 0,01663004 ! gland morphogenesis GO:0022612 10 10 1,000 1,985E-03 0,01655479 ! regulation of erythrocyte differentiation GO:0045646 10 10 1,000 1,985E-03 0,01648022 ! lymphocyte homeostasis GO:0002260 10 10 1,000 1,985E-03 0,01640631 ! epithelial to mesenchymal transition GO:0001837 10 10 1,000 1,985E-03 0,01633307 ! gut development GO:0048565 10 10 1,000 1,985E-03 0,01626048 ! positive regulation of neuron apoptosis GO:0043525 10 10 1,000 1,985E-03 0,01618853 ! neuron projection development GO:0031175 85 80 3,000 2,069E-03 0,01679562 ! cell-matrix adhesion GO:0007160 39 38 2,000 2,132E-03 0,01723321 ! steroid hormone receptor signaling pathway GO:0030518 38 38 2,000 2,132E-03 0,01715796 ! tube development GO:0035295 83 81 3,000 2,165E-03 0,01735109 ! respiratory tube development GO:0030323 40 39 2,000 2,299E-03 0,01833909 ! respiratory system development GO:0060541 40 39 2,000 2,299E-03 0,01826005 ! lymphocyte differentiation GO:0030098 39 39 2,000 2,299E-03 0,01818168 ! myeloid leukocyte differentiation GO:0002573 12 11 1,000 2,416E-03 0,01902648 ! G1 phase of mitotic cell cycle GO:0000080 12 11 1,000 2,416E-03 0,01894552 ! positive regulation of hormone secretion GO:0046887 11 11 1,000 2,416E-03 0,01886524 ! protein amino acid acetylation GO:0006473 11 11 1,000 2,416E-03 0,01878564 ! regulation of viral genome replication GO:0045069 11 11 1,000 2,416E-03 0,01870671 ! activation of MAPKK activity GO:0000186 12 11 1,000 2,416E-03 0,01862844 ! cellular response to starvation GO:0009267 11 11 1,000 2,416E-03 0,01855082 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 1,000 2,416E-03 0,01847385 ! G1/S transition checkpoint GO:0031575 12 11 1,000 2,416E-03 0,01839751 ! interaction with host GO:0051701 11 11 1,000 2,416E-03 0,0183218 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 2,416E-03 0,01824671 ! oogenesis GO:0048477 11 11 1,000 2,416E-03 0,01817223 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 1,000 2,416E-03 0,01809836 GO:0006109|regulation of carbohydrate metabolic process, ! hindbrain development GO:0030902 11 11 1,000 2,416E-03 0,01802509 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 2,416E-03 0,01795241 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 2,000 2,473E-03 0,01830526 ! myeloid cell differentiation GO:0030099 42 40 2,000 2,473E-03 0,01823204 ! positive regulation of cell differentiation GO:0045597 87 85 3,000 2,583E-03 0,01896843 ! heart development GO:0007507 90 87 3,000 2,812E-03 0,02056412 ! protein amino acid ADP-ribosylation GO:0006471 12 12 1,000 2,886E-03 0,0210254 ! xenobiotic metabolic process GO:0006805 12 12 1,000 2,886E-03 0,02094262 ! male gonad development GO:0008584 12 12 1,000 2,886E-03 0,02086049 ! regulation of insulin secretion GO:0050796 12 12 1,000 2,886E-03 0,02077901 ! renal system process GO:0003014 12 12 1,000 2,886E-03 0,02069815 ! regulation of chromosome organization GO:0033044 12 12 1,000 2,886E-03 0,02061793 ! positive regulation of multicellular organism growth GO:0040018 12 12 1,000 2,886E-03 0,02053832 ! somitogenesis GO:0001756 13 12 1,000 2,886E-03 0,02045933 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 1,000 2,886E-03 0,02038094 ! negative regulation of translation GO:0017148 12 12 1,000 2,886E-03 0,02030315 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 1,000 2,886E-03 0,02022595 ! mitochondrion organization GO:0007005 44 43 2,000 3,045E-03 0,0212593 ! homeostasis of number of cells GO:0048872 44 43 2,000 3,045E-03 0,02117907 ! positive regulation of DNA replication GO:0045740 14 13 1,000 3,396E-03 0,02353118 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 1,000 3,396E-03 0,02344305 ! G2/M transition of mitotic cell cycle GO:0000086 13 13 1,000 3,396E-03 0,02335558 ! negative regulation of hormone secretion GO:0046888 13 13 1,000 3,396E-03 0,02326875 ! regeneration GO:0031099 13 13 1,000 3,396E-03 0,02318257 ! post-embryonic development GO:0009791 14 13 1,000 3,396E-03 0,02309703 ! vasculogenesis GO:0001570 13 13 1,000 3,396E-03 0,02301211 ! negative regulation of DNA replication GO:0008156 13 13 1,000 3,396E-03 0,02292782 ! receptor metabolic process GO:0043112 14 13 1,000 3,396E-03 0,02284414 ! actin filament bundle formation GO:0051017 13 13 1,000 3,396E-03 0,02276107 ! ureteric bud development GO:0001657 13 13 1,000 3,396E-03 0,0226786 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 1,000 3,396E-03 0,02259673 ! regulation of endothelial cell migration GO:0010594 13 13 1,000 3,396E-03 0,02251545 ! response to endoplasmic reticulum stress GO:0034976 13 13 1,000 3,396E-03 0,02243475 ! regulation of peptide secretion GO:0002791 13 13 1,000 3,396E-03 0,02235462 ! regulation of viral reproduction GO:0050792 13 13 1,000 3,396E-03 0,02227507 ! positive regulation of locomotion GO:0040017 13 13 1,000 3,396E-03 0,02219608 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! long-chain fatty acid transport GO:0015909 13 13 1,000 3,396E-03 0,02211765 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 3,396E-03 0,02203977 ! response to cytokine stimulus GO:0034097 13 13 1,000 3,396E-03 0,02196244 ! activation of JUN kinase activity GO:0007257 13 13 1,000 3,396E-03 0,02188565 ! tissue homeostasis GO:0001894 13 13 1,000 3,396E-03 0,02180939 GO:0048871|multicellular organismal homeostasis, ! regulation of membrane potential GO:0042391 46 46 2,000 3,693E-03 0,02363035 ! protein amino acid acylation GO:0043543 14 14 1,000 3,945E-03 0,02515853 ! hair cycle GO:0042633 14 14 1,000 3,945E-03 0,02507177 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! negative regulation of epithelial cell proliferation GO:0050680 14 14 1,000 3,945E-03 0,02498562 ! multicellular organismal response to stress GO:0033555 14 14 1,000 3,945E-03 0,02490005 ! regulation of behavior GO:0050795 14 14 1,000 3,945E-03 0,02481507 ! base-excision repair GO:0006284 14 14 1,000 3,945E-03 0,02473066 ! response to organic cyclic substance GO:0014070 15 14 1,000 3,945E-03 0,02464683 ! positive regulation of inflammatory response GO:0050729 14 14 1,000 3,945E-03 0,02456356 ! actin filament organization GO:0007015 50 48 2,000 4,167E-03 0,02586077 ! DNA recombination GO:0006310 48 48 2,000 4,167E-03 0,02577399 ! posttranscriptional regulation of gene expression GO:0010608 98 98 3,000 4,32E-03 0,0266302 ! gland development GO:0048732 51 49 2,000 4,418E-03 0,02714228 ! cell cycle arrest GO:0007050 49 49 2,000 4,418E-03 0,0270521 ! skeletal muscle tissue development GO:0007519 50 49 2,000 4,418E-03 0,02696253 GO:0060538|skeletal muscle organ development, ! response to nutrient GO:0007584 49 49 2,000 4,418E-03 0,02687354 ! protein import into nucleus, translocation GO:0000060 15 15 1,000 4,532E-03 0,02747698 ! positive regulation of fibroblast proliferation GO:0048146 15 15 1,000 4,532E-03 0,02738689 ! striated muscle cell differentiation GO:0051146 16 15 1,000 4,532E-03 0,0272974 ! ovarian follicle development GO:0001541 15 15 1,000 4,532E-03 0,02720848 ! ER-nuclear signaling pathway GO:0006984 15 15 1,000 4,532E-03 0,02712014 ! response to starvation GO:0042594 15 15 1,000 4,532E-03 0,02703237 ! leukocyte homeostasis GO:0001776 15 15 1,000 4,532E-03 0,02694517 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 1,000 4,532E-03 0,02685853 ! negative regulation of cell activation GO:0050866 15 15 1,000 4,532E-03 0,02677245 ! protein homooligomerization GO:0051260 15 15 1,000 4,532E-03 0,02668691 ! muscle organ development GO:0007517 102 100 3,000 4,644E-03 0,0272548 ! regulation of DNA metabolic process GO:0051052 51 50 2,000 4,678E-03 0,02736913 ! T cell activation GO:0042110 51 50 2,000 4,678E-03 0,02728252 ! regulation of neurogenesis GO:0050767 51 50 2,000 4,678E-03 0,02719645 ! positive regulation of mitosis GO:0045840 16 16 1,000 5,157E-03 0,02988959 GO:0051785|positive regulation of nuclear division, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 1,000 5,157E-03 0,0297959 ! segmentation GO:0035282 17 16 1,000 5,157E-03 0,02970278 ! triglyceride metabolic process GO:0006641 16 16 1,000 5,157E-03 0,02961025 ! positive regulation of cell development GO:0010720 16 16 1,000 5,157E-03 0,02951829 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 1,000 5,157E-03 0,02942691 ! lymphocyte proliferation GO:0046651 16 16 1,000 5,157E-03 0,02933608 ! fatty acid transport GO:0015908 16 16 1,000 5,157E-03 0,02924582 ! cellular response to nutrient levels GO:0031669 16 16 1,000 5,157E-03 0,02915611 ! polyol metabolic process GO:0019751 16 16 1,000 5,157E-03 0,02906694 ! serine family amino acid metabolic process GO:0009069 16 16 1,000 5,157E-03 0,02897833 ! positive regulation of catabolic process GO:0009896 16 16 1,000 5,157E-03 0,02889025 ! regulation of JUN kinase activity GO:0043506 17 16 1,000 5,157E-03 0,0288027 GO:0043507|positive regulation of JUN kinase activity, ! response to xenobiotic stimulus GO:0009410 16 16 1,000 5,157E-03 0,02871568 ! protein amino acid dephosphorylation GO:0006470 55 54 2,000 5,808E-03 0,03224269 ! myelination GO:0042552 17 17 1,000 5,82E-03 0,03220876 ! glucose transport GO:0015758 17 17 1,000 5,82E-03 0,03211232 ! tissue remodeling GO:0048771 17 17 1,000 5,82E-03 0,03201646 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 5,82E-03 0,03192118 ! negative regulation of cell development GO:0010721 18 17 1,000 5,82E-03 0,03182646 GO:0050768|negative regulation of neurogenesis, ! regulation of oxidoreductase activity GO:0051341 17 17 1,000 5,82E-03 0,03173229 ! regulation of osteoblast differentiation GO:0045667 17 17 1,000 5,82E-03 0,03163869 ! pigmentation GO:0043473 17 17 1,000 5,82E-03 0,03154563 ! liver development GO:0001889 17 17 1,000 5,82E-03 0,03145313 ! reproductive developmental process GO:0003006 56 56 2,000 6,43E-03 0,03464845 ! regulation of nervous system development GO:0051960 57 56 2,000 6,43E-03 0,03454743 ! regulation of cellular catabolic process GO:0031329 18 18 1,000 6,519E-03 0,0349242 ! mononuclear cell proliferation GO:0032943 18 18 1,000 6,519E-03 0,03482297 GO:0070661|leukocyte proliferation, ! hexose transport GO:0008645 18 18 1,000 6,519E-03 0,03472233 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 1,000 6,519E-03 0,03462227 GO:0055092|sterol homeostasis, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 6,519E-03 0,03452278 ! neutral lipid metabolic process GO:0006638 18 18 1,000 6,519E-03 0,03442386 GO:0006639|acylglycerol metabolic process, ! cellular response to extracellular stimulus GO:0031668 18 18 1,000 6,519E-03 0,0343255 ! ensheathment of neurons GO:0007272 18 18 1,000 6,519E-03 0,03422771 GO:0008366|axon ensheathment, ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 1,000 6,519E-03 0,03413047 ! regulation of binding GO:0051098 60 57 2,000 6,755E-03 0,03526562 ! regulation of protein localization GO:0032880 58 57 2,000 6,755E-03 0,035166 ! negative regulation of DNA metabolic process GO:0051053 19 19 1,000 7,254E-03 0,03765966 ! regulation of pH GO:0006885 19 19 1,000 7,254E-03 0,03755387 ! regulation of endothelial cell proliferation GO:0001936 19 19 1,000 7,254E-03 0,03744868 ! regulation of striated muscle tissue development GO:0016202 20 19 1,000 7,254E-03 0,03734408 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 7,254E-03 0,03724005 ! metanephros development GO:0001656 19 19 1,000 7,254E-03 0,03713661 ! peripheral nervous system development GO:0007422 19 19 1,000 7,254E-03 0,03703374 ! regulation of protein stability GO:0031647 19 19 1,000 7,254E-03 0,03693143 ! regulation of cell shape GO:0008360 21 19 1,000 7,254E-03 0,03682969 ! response to heat GO:0009408 19 19 1,000 7,254E-03 0,03672851 ! dephosphorylation GO:0016311 60 59 2,000 7,434E-03 0,03753484 ! regulation of cell development GO:0060284 60 59 2,000 7,434E-03 0,03743229 ! regulation of muscle development GO:0048634 21 20 1,000 8,025E-03 0,04030066 ! organic ether metabolic process GO:0018904 20 20 1,000 8,025E-03 0,04019114 GO:0006662|glycerol ether metabolic process, ! positive regulation of gene-specific transcription GO:0043193 20 20 1,000 8,025E-03 0,04008223 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 8,025E-03 0,0399739 ! female gamete generation GO:0007292 20 20 1,000 8,025E-03 0,03986615 ! negative regulation of neuron apoptosis GO:0043524 21 20 1,000 8,025E-03 0,03975898 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 2,000 8,152E-03 0,04027826 ! morphogenesis of an epithelium GO:0002009 63 62 2,000 8,526E-03 0,04201316 GO:0060429|epithelium development, ! mitotic sister chromatid segregation GO:0000070 21 21 1,000 8,832E-03 0,04340397 ! mammary gland development GO:0030879 23 21 1,000 8,832E-03 0,04328853 ! regulation of action potential in neuron GO:0019228 21 21 1,000 8,832E-03 0,04317371 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 8,832E-03 0,04305949 ! angiogenesis GO:0001525 65 64 2,000 9,304E-03 0,04524119 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 9,673E-03 0,04691238 GO:0090047|positive regulation of transcription regulator activity, ! positive regulation of DNA metabolic process GO:0051054 23 22 1,000 9,673E-03 0,04678925 ! sister chromatid segregation GO:0000819 22 22 1,000 9,673E-03 0,04666677 ! hormone-mediated signaling GO:0009755 22 22 1,000 9,673E-03 0,04654492 ! ovulation cycle process GO:0022602 22 22 1,000 9,673E-03 0,04642371 ! spindle organization GO:0007051 22 22 1,000 9,673E-03 0,04630313 ! erythrocyte differentiation GO:0030218 23 22 1,000 9,673E-03 0,04618317 ! male sex differentiation GO:0046661 22 22 1,000 9,673E-03 0,04606384 ! sterol biosynthetic process GO:0016126 22 22 1,000 9,673E-03 0,04594512 ! neuron migration GO:0001764 22 22 1,000 9,673E-03 0,045827 ! cytokine production GO:0001816 22 22 1,000 9,673E-03 0,0457095 ! cytokinesis GO:0000910 23 22 1,000 9,673E-03 0,0455926 ! negative regulation of cell differentiation GO:0045596 68 67 2,000 0,01054597 0,04958222 ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,01054807 0,04946586 ! epithelial cell differentiation GO:0030855 23 23 1,000 0,01054807 0,04934032 ! regulation of hormone secretion GO:0046883 23 23 1,000 0,01054807 0,0492154 ! response to estrogen stimulus GO:0043627 23 23 1,000 0,01054807 0,04909112 ! mitotic cell cycle checkpoint GO:0007093 24 23 1,000 0,01054807 0,04896747 ! endocrine system development GO:0035270 23 23 1,000 0,01054807 0,04884443 ! female gonad development GO:0008585 23 23 1,000 0,01054807 0,04872202 ! monovalent inorganic cation homeostasis GO:0055067 23 23 1,000 0,01054807 0,04860021 ! calcium-mediated signaling GO:0019722 23 23 1,000 0,01054807 0,04847901 ! regulation of JNK cascade GO:0046328 25 23 1,000 0,01054807 0,04835842 ! cell projection assembly GO:0030031 25 23 1,000 0,01054807 0,04823842 ! regulation of action potential GO:0001508 24 24 1,000 0,01145726 0,05226666 ! gliogenesis GO:0042063 24 24 1,000 0,01145726 0,05213761 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 1,000 0,01145726 0,05200919 ! cellular amino acid biosynthetic process GO:0008652 24 24 1,000 0,01145726 0,0518814 ! erythrocyte homeostasis GO:0034101 25 24 1,000 0,01145726 0,05175424 ! ovulation cycle GO:0042698 24 24 1,000 0,01145726 0,0516277 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 0,01145726 0,05150178 ! growth GO:0040007 70 70 2,000 0,01188048 0,05327428 ! carboxylic acid biosynthetic process GO:0046394 70 70 2,000 0,01188048 0,05314498 GO:0016053|organic acid biosynthetic process, ! negative regulation of secretion GO:0051048 26 25 1,000 0,01239976 0,05533355 ! regulation of intracellular protein transport GO:0033157 25 25 1,000 0,01239976 0,05519989 ! development of primary female sexual characteristics GO:0046545 25 25 1,000 0,01239976 0,05506688 GO:0046660|female sex differentiation, ! regulation of T cell proliferation GO:0042129 25 25 1,000 0,01239976 0,05493451 ! positive regulation of DNA binding GO:0043388 26 25 1,000 0,01239976 0,05480277 ! heart morphogenesis GO:0003007 25 25 1,000 0,01239976 0,05467166 ! negative regulation of immune system process GO:0002683 25 25 1,000 0,01239976 0,05454118 ! positive regulation of hydrolase activity GO:0051345 72 72 2,000 0,01282188 0,05626363 ! positive regulation of binding GO:0051099 27 26 1,000 0,01337508 0,05855173 ! positive regulation of defense response GO:0031349 26 26 1,000 0,01337508 0,05841298 ! glycolysis GO:0006096 26 26 1,000 0,01337508 0,05827489 ! induction of apoptosis by intracellular signals GO:0008629 26 26 1,000 0,01337508 0,05813745 ! regulation of T cell differentiation GO:0045580 26 26 1,000 0,01337508 0,05800065 ! germ cell development GO:0007281 27 26 1,000 0,01337508 0,0578645 ! pigment metabolic process GO:0042440 26 26 1,000 0,01337508 0,05772899 ! synapse organization GO:0050808 26 26 1,000 0,01337508 0,05759411 ! response to oxidative stress GO:0006979 76 75 2,000 0,01431231 0,06148621 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 1,000 0,01438276 0,06164518 ! monocarboxylic acid transport GO:0015718 27 27 1,000 0,01438276 0,06150215 ! activation of caspase activity GO:0006919 27 27 1,000 0,01438276 0,06135978 ! stress-activated protein kinase signaling pathway GO:0031098 28 28 1,000 0,01542232 0,06564282 GO:0007254|JNK cascade, ! carbohydrate transport GO:0008643 28 28 1,000 0,01542232 0,06549157 ! histone modification GO:0016570 28 28 1,000 0,01542232 0,06534101 ! developmental growth GO:0048589 28 28 1,000 0,01542232 0,06519115 ! regulation of mast cell proliferation GO:0070666 28 28 1,000 0,01542232 0,06504197 ! regulation of protein modification process GO:0031399 79 78 2,000 0,01589748 0,06689282 ! nuclear transport GO:0051169 79 79 2,000 0,01644705 0,06904763 GO:0006913|nucleocytoplasmic transport, ! viral reproductive process GO:0022415 29 29 1,000 0,01649331 0,06908447 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,01649331 0,06892781 ! covalent chromatin modification GO:0016569 29 29 1,000 0,01649331 0,06877187 ! regulation of lymphocyte proliferation GO:0050670 29 29 1,000 0,01649331 0,06861663 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! lymphocyte activation GO:0046649 82 81 2,000 0,01757809 0,0729649 ! response to reactive oxygen species GO:0000302 31 30 1,000 0,01759526 0,07287204 ! positive regulation of peptidase activity GO:0010952 30 30 1,000 0,01759526 0,07270865 GO:0043280|positive regulation of caspase activity, ! activation of phospholipase C activity GO:0007202 30 30 1,000 0,01759526 0,07254599 GO:0010863|positive regulation of phospholipase C activity, ! response to temperature stimulus GO:0009266 30 30 1,000 0,01759526 0,07238406 ! vascular process in circulatory system GO:0003018 31 30 1,000 0,01759526 0,07222284 ! regulation of inflammatory response GO:0050727 30 30 1,000 0,01759526 0,07206235 ! vesicle organization GO:0016050 30 30 1,000 0,01759526 0,07190257 ! establishment of organelle localization GO:0051656 31 30 1,000 0,01759526 0,07174349 ! skeletal muscle fiber development GO:0048741 31 31 1,000 0,01872771 0,07619244 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 0,01872771 0,07602462 ! regulation of intracellular transport GO:0032386 31 31 1,000 0,01872771 0,07585753 ! blood vessel morphogenesis GO:0048514 84 83 2,000 0,01875178 0,07578844 ! muscle fiber development GO:0048747 32 32 1,000 0,01989023 0,08021378 ! glucose catabolic process GO:0006007 32 32 1,000 0,01989023 0,08003864 ! regulation of phospholipase activity GO:0010517 32 32 1,000 0,01989023 0,07986427 ! cell maturation GO:0048469 32 32 1,000 0,01989023 0,07969065 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 1,000 0,01989023 0,07951778 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,01989023 0,07934567 ! nuclear export GO:0051168 32 32 1,000 0,01989023 0,07917429 ! regulation of lymphocyte differentiation GO:0045619 32 32 1,000 0,01989023 0,07900366 ! kidney development GO:0001822 32 32 1,000 0,01989023 0,07883376 ! positive regulation of lipase activity GO:0060193 32 32 1,000 0,01989023 0,07866459 ! nitrogen compound biosynthetic process GO:0044271 86 85 2,000 0,01996824 0,07880401 ! positive regulation of response to stimulus GO:0048584 86 85 2,000 0,01996824 0,07863562 ! regulation of cellular response to stress GO:0080135 35 33 1,000 0,02108237 0,08284605 ! activation of protein kinase activity GO:0032147 35 33 1,000 0,02108237 0,08266979 ! regulation of neuron differentiation GO:0045664 34 33 1,000 0,02108237 0,08249427 ! response to metal ion GO:0010038 34 34 1,000 0,02230367 0,08708828 ! ear development GO:0043583 34 34 1,000 0,02230367 0,08690416 ! muscle cell differentiation GO:0042692 35 34 1,000 0,02230367 0,08672082 ! regulation of lipid metabolic process GO:0019216 34 34 1,000 0,02230367 0,08653825 ! secondary metabolic process GO:0019748 34 34 1,000 0,02230367 0,08635645 ! viral reproduction GO:0016032 34 34 1,000 0,02230367 0,08617541 ! brain development GO:0007420 91 90 2,000 0,02319706 0,08943971 ! regulation of cell morphogenesis GO:0022604 38 35 1,000 0,02355372 0,09062527 ! positive regulation of phosphorylation GO:0042327 35 35 1,000 0,02355372 0,09043646 ! fatty acid metabolic process GO:0006631 93 92 2,000 0,02456376 0,09411852 ! response to inorganic substance GO:0010035 36 36 1,000 0,02483207 0,09494918 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 1,000 0,02483207 0,0947526 ! regulation of mitosis GO:0007088 37 36 1,000 0,02483207 0,09455683 GO:0051783|regulation of nuclear division, ! positive regulation of phosphorus metabolic process GO:0010562 36 36 1,000 0,02483207 0,09436187 GO:0045937|positive regulation of phosphate metabolic process, ! female pregnancy GO:0007565 37 36 1,000 0,02483207 0,09416771 ! positive regulation of organelle organization GO:0010638 36 36 1,000 0,02483207 0,09397434 ! gonad development GO:0008406 36 36 1,000 0,02483207 0,09378177 ! regulation of lipase activity GO:0060191 36 36 1,000 0,02483207 0,09358999 ! tissue morphogenesis GO:0048729 94 93 2,000 0,02526322 0,09502064 ! blood vessel development GO:0001568 95 94 2,000 0,02597342 0,0974929 ! regulation of transcription factor activity GO:0051090 38 37 1,000 0,0261383 0,09791237 GO:0090046|regulation of transcription regulator activity, ! regulation of Rho protein signal transduction GO:0035023 37 37 1,000 0,0261383 0,09771377 ! adaptive immune response GO:0002250 37 37 1,000 0,0261383 0,09751597 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! vasculature development GO:0001944 97 96 2,000 0,02742602 0,10211344 ! positive regulation of secretion GO:0051047 39 38 1,000 0,02747199 0,10207837 ! exocytosis GO:0006887 40 38 1,000 0,02747199 0,10187298 ! chromosome segregation GO:0007059 38 38 1,000 0,02747199 0,10166842 ! urogenital system development GO:0001655 38 38 1,000 0,02747199 0,10146467 ! hexose catabolic process GO:0019320 38 38 1,000 0,02747199 0,10126174 ! axon guidance GO:0007411 39 38 1,000 0,02747199 0,10105963 ! fatty acid biosynthetic process GO:0006633 39 39 1,000 0,02883271 0,10585396 ! nucleotide-excision repair GO:0006289 40 39 1,000 0,02883271 0,10564351 ! regulation of MAPKKK cascade GO:0043408 41 39 1,000 0,02883271 0,1054339 ! developmental maturation GO:0021700 39 39 1,000 0,02883271 0,10522512 ! blood circulation GO:0008015 99 98 2,000 0,0289215 0,10534056 GO:0003013|circulatory system process, ! anti-apoptosis GO:0006916 100 99 2,000 0,0296853 0,10790927 ! organelle localization GO:0051640 41 40 1,000 0,03022006 0,10963694 ! regulation of caspase activity GO:0043281 41 41 1,000 0,03163361 0,11453978 ! monosaccharide catabolic process GO:0046365 41 41 1,000 0,03163361 0,11431519 ! regulation of endopeptidase activity GO:0052548 42 42 1,000 0,03307298 0,11928277 ! development of primary sexual characteristics GO:0045137 42 42 1,000 0,03307298 0,11904979 ! response to protein stimulus GO:0051789 42 42 1,000 0,03307298 0,11881773 ! forebrain development GO:0030900 43 42 1,000 0,03307298 0,11858656 ! rRNA transcription GO:0009303 5 5 0,000 0,03370314 0,12061143 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,03370314 0,12037769 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,03370314 0,12014485 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,03370314 0,11991291 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,03370314 0,11968186 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,03370314 0,1194517 ! reproductive cellular process GO:0048610 5 5 0,000 0,03370314 0,11922243 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,03370314 0,11899403 ! prostate gland development GO:0030850 5 5 0,000 0,03370314 0,11876651 ! water transport GO:0006833 5 5 0,000 0,03370314 0,11853986 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,03370314 0,11831407 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,03370314 0,11808914 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,03370314 0,11786506 ! glycerol metabolic process GO:0006071 5 5 0,000 0,03370314 0,11764183 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,03370314 0,11741944 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,03370314 0,1171979 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,03370314 0,11697719 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,03370314 0,1167573 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,03370314 0,11653825 ! filopodium assembly GO:0046847 7 5 0,000 0,03370314 0,11632001 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,03370314 0,11610259 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,03370314 0,11588598 ! GTP metabolic process GO:0046039 5 5 0,000 0,03370314 0,11567018 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,03370314 0,11545518 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,03370314 0,11524098 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,03370314 0,11502757 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,03370314 0,11481495 ! social behavior GO:0035176 5 5 0,000 0,03370314 0,11460311 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,03370314 0,11439205 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,03370314 0,11418178 ! memory GO:0007613 5 5 0,000 0,03370314 0,11397227 ! dopamine receptor signaling pathway GO:0007212 5 5 0,000 0,03370314 0,11376353 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,03370314 0,11355555 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,03370314 0,11334833 ! erythrocyte maturation GO:0043249 5 5 0,000 0,03370314 0,11314187 ! hippocampus development GO:0021766 6 5 0,000 0,03370314 0,11293616 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,03370314 0,11273119 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,03370314 0,11252697 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,03370314 0,11232348 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,03370314 0,11212073 ! mechanosensory behavior GO:0007638 5 5 0,000 0,03370314 0,11191871 ! heart looping GO:0001947 5 5 0,000 0,03370314 0,11171742 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,03370314 0,11151685 ! response to interferon-gamma GO:0034341 5 5 0,000 0,03370314 0,111317 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,03370314 0,11111786 ! pH reduction GO:0045851 5 5 0,000 0,03370314 0,11091944 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,03370314 0,11072172 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,03370314 0,11052471 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,03370314 0,11032839 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,03370314 0,11013278 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,03370314 0,10993785 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,03370314 0,10974361 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,03370314 0,10955006 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,03370314 0,10935719 ! adrenal gland development GO:0030325 5 5 0,000 0,03370314 0,109165 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,03370314 0,10897348 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,03370314 0,10878264 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,03370314 0,10859246 ! astrocyte differentiation GO:0048708 5 5 0,000 0,03370314 0,10840294 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,03370314 0,10821409 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,03370314 0,10802589 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,03370314 0,10783834 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,03370314 0,10765145 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,03370314 0,1074652 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,03370314 0,1072796 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,03370314 0,10709463 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,03370314 0,1069103 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,03370314 0,10672661 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,03370314 0,10654354 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,03370314 0,10636111 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,03370314 0,10617929 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,03370314 0,1059981 ! response to ATP GO:0033198 5 5 0,000 0,03370314 0,10581752 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,03370314 0,10563756 ! regulation of appetite GO:0032098 5 5 0,000 0,03370314 0,10545821 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,03370314 0,10527947 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,03370314 0,10510133 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,03370314 0,10492379 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,03370314 0,10474686 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03370314 0,10457051 ! receptor clustering GO:0043113 5 5 0,000 0,03370314 0,10439477 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,03370314 0,10421961 ! actin cytoskeleton reorganization GO:0031532 5 5 0,000 0,03370314 0,10404503 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,03370314 0,10387105 ! retinol metabolic process GO:0042572 5 5 0,000 0,03370314 0,10369764 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,03370314 0,10352481 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,03370314 0,10335256 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,03370314 0,10318087 ! parturition GO:0007567 5 5 0,000 0,03370314 0,10300976 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03370314 0,10283921 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 0,03370314 0,10266923 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,03370314 0,10249981 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,03370314 0,10233095 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,03370314 0,10216264 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,03370314 0,10199489 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,03370314 0,10182768 ! oligodendrocyte development GO:0014003 5 5 0,000 0,03370314 0,10166102 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,03370314 0,10149491 ! activated T cell proliferation GO:0050798 5 5 0,000 0,03370314 0,10132934 ! interaction with symbiont GO:0051702 5 5 0,000 0,03370314 0,10116431 ! cellular extravasation GO:0045123 5 5 0,000 0,03370314 0,10099981 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,03370314 0,10083585 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,03370314 0,10067242 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,03370314 0,10050952 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,03370314 0,10034715 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,03370314 0,1001853 ! response to amine stimulus GO:0014075 5 5 0,000 0,03370314 0,10002397 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,03370314 0,09986316 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,03370314 0,09970287 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,03370314 0,09954309 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,03370314 0,09938382 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,03370314 0,09922506 ! neuron recognition GO:0008038 5 5 0,000 0,03370314 0,0990668 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,03370314 0,09890905 ! decidualization GO:0046697 5 5 0,000 0,03370314 0,09875181 ! hair follicle maturation GO:0048820 5 5 0,000 0,03370314 0,09859506 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,03370314 0,0984388 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,03370314 0,09828305 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,03370314 0,09812778 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,03370314 0,09797301 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,03370314 0,09781872 ! postreplication repair GO:0006301 5 5 0,000 0,03370314 0,09766491 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,03370314 0,09751159 GO:0021517|ventral spinal cord development, ! histone methylation GO:0016571 5 5 0,000 0,03370314 0,09735876 ! DNA methylation GO:0006306 5 5 0,000 0,03370314 0,09720639 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03370314 0,09705451 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,03370314 0,0969031 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,03370314 0,09675216 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,03370314 0,09660169 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,03370314 0,09645169 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,03370314 0,09630215 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,03370314 0,09615307 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,03370314 0,09600446 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,03370314 0,09585631 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,03370314 0,09570861 ! sterol catabolic process GO:0016127 5 5 0,000 0,03370314 0,09556136 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,03370314 0,09541457 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,03370314 0,09526823 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,03370314 0,09512234 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,03370314 0,09497689 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,03370314 0,09483189 ! zymogen activation GO:0031638 5 5 0,000 0,03370314 0,09468733 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,03370314 0,09454321 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,03370314 0,09439952 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,03370314 0,09425628 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,03370314 0,09411346 ! nucleosome positioning GO:0016584 5 5 0,000 0,03370314 0,09397108 ! regulation of isotype switching GO:0045191 5 5 0,000 0,03370314 0,09382913 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,03370314 0,09368761 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,03370314 0,09354651 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,03370314 0,09340584 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,03370314 0,09326559 ! NADPH regeneration GO:0006740 5 5 0,000 0,03370314 0,09312577 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,03370314 0,09298636 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,03370314 0,09284736 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,03370314 0,09270878 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,03370314 0,09257062 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,03370314 0,09243287 ! sarcomere organization GO:0045214 5 5 0,000 0,03370314 0,09229552 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,03370314 0,09215858 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,03370314 0,09202205 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,03370314 0,09188593 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,03370314 0,0917502 GO:0045622|regulation of T-helper cell differentiation, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,03370314 0,09161488 ! male genitalia development GO:0030539 5 5 0,000 0,03370314 0,09147995 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,03370314 0,09134542 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,03370314 0,09121129 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,03370314 0,09107755 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,03370314 0,0909442 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,03370314 0,09081124 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,03370314 0,09067867 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,03370314 0,09054648 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,03370314 0,09041468 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,03370314 0,09028326 ! ATP catabolic process GO:0006200 5 5 0,000 0,03370314 0,09015223 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03370314 0,09002157 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,03370314 0,0898913 ! blastocyst formation GO:0001825 5 5 0,000 0,03370314 0,0897614 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,03370314 0,08963187 ! embryonic gut development GO:0048566 5 5 0,000 0,03370314 0,08950272 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,03370314 0,08937394 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,03370314 0,08924553 ! activation of innate immune response GO:0002218 5 5 0,000 0,03370314 0,08911748 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,03370314 0,08898981 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,03370314 0,0888625 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,03370314 0,08873555 ! muscle adaptation GO:0043500 5 5 0,000 0,03370314 0,08860897 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,03370314 0,08848274 ! embryonic heart tube development GO:0035050 5 5 0,000 0,03370314 0,08835688 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,03370314 0,08823137 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,03370314 0,08810622 ! defense response to fungus GO:0050832 5 5 0,000 0,03370314 0,08798142 ! lysogeny GO:0030069 5 5 0,000 0,03370314 0,08785698 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,03370314 0,08773289 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,03370314 0,08760915 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,03370314 0,08748575 ! establishment of cell polarity GO:0030010 5 5 0,000 0,03370314 0,08736271 ! mitochondrion localization GO:0051646 5 5 0,000 0,03370314 0,08724001 ! nucleus localization GO:0051647 5 5 0,000 0,03370314 0,08711765 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,03370314 0,08699564 ! reproductive structure development GO:0048608 43 43 1,000 0,03453774 0,08902525 ! alcohol catabolic process GO:0046164 43 43 1,000 0,03453774 0,08890092 ! humoral immune response GO:0006959 44 44 1,000 0,03602751 0,09260628 ! protein import into nucleus GO:0006606 44 44 1,000 0,03602751 0,0924773 ! negative regulation of organelle organization GO:0010639 45 44 1,000 0,03602751 0,09234868 ! amine biosynthetic process GO:0009309 46 45 1,000 0,03754189 0,09609682 ! homophilic cell adhesion GO:0007156 45 45 1,000 0,03754189 0,09596354 ! regulation of DNA binding GO:0051101 47 45 1,000 0,03754189 0,09583062 ! phosphoinositide-mediated signaling GO:0048015 45 45 1,000 0,03754189 0,09569808 ! steroid biosynthetic process GO:0006694 46 45 1,000 0,03754189 0,0955659 ! nuclear import GO:0051170 45 45 1,000 0,03754189 0,09543408 ! Wnt receptor signaling pathway GO:0016055 46 45 1,000 0,03754189 0,09530263 ! tube morphogenesis GO:0035239 47 46 1,000 0,0390805 0,09907201 ! regulation of peptidase activity GO:0052547 46 46 1,000 0,0390805 0,09893592 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,0403091 0,10190626 ! axon extension GO:0048675 7 6 0,000 0,0403091 0,10176666 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,0403091 0,10162745 ! tRNA modification GO:0006400 6 6 0,000 0,0403091 0,10148861 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,0403091 0,10135016 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,0403091 0,10121208 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,0403091 0,10107437 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,0403091 0,10093704 ! regulation of S phase GO:0033261 6 6 0,000 0,0403091 0,10080009 ! myotube differentiation GO:0014902 6 6 0,000 0,0403091 0,1006635 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,0403091 0,10052729 ! bone remodeling GO:0046849 6 6 0,000 0,0403091 0,10039144 ! N-glycan processing GO:0006491 6 6 0,000 0,0403091 0,10025596 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,0403091 0,10012084 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,0403091 0,09998609 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,0403091 0,0998517 ! RNA methylation GO:0001510 6 6 0,000 0,0403091 0,09971767 ! cartilage condensation GO:0001502 7 6 0,000 0,0403091 0,099584 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,0403091 0,09945069 ! succinate metabolic process GO:0006105 7 6 0,000 0,0403091 0,09931773 ! artery development GO:0060840 6 6 0,000 0,0403091 0,09918513 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,0403091 0,09905289 ! bile acid metabolic process GO:0008206 6 6 0,000 0,0403091 0,09892099 ! androgen metabolic process GO:0008209 6 6 0,000 0,0403091 0,09878945 ! estrogen metabolic process GO:0008210 6 6 0,000 0,0403091 0,09865825 ! limbic system development GO:0021761 7 6 0,000 0,0403091 0,09852741 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,0403091 0,09839691 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 0,000 0,0403091 0,09826675 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,0403091 0,09813694 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,0403091 0,09800747 ! pathogenesis GO:0009405 6 6 0,000 0,0403091 0,09787835 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,0403091 0,09774956 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,0403091 0,09762111 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,0403091 0,097493 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,0403091 0,09736522 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,0403091 0,09723778 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,0403091 0,09711067 ! arginine metabolic process GO:0006525 6 6 0,000 0,0403091 0,0969839 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,0403091 0,09685745 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,0403091 0,09673133 ! glutamate catabolic process GO:0006538 7 6 0,000 0,0403091 0,09660554 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,0403091 0,09648008 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,0403091 0,09635495 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,0403091 0,09623013 GO:0005978|glycogen biosynthetic process, ! V(D)J recombination GO:0033151 6 6 0,000 0,0403091 0,09610565 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,0403091 0,09598148 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,0403091 0,09585763 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,0403091 0,0957341 ! regulation of heart rate GO:0002027 6 6 0,000 0,0403091 0,09561089 ! lipid digestion GO:0044241 6 6 0,000 0,0403091 0,095488 ! asymmetric protein localization GO:0008105 6 6 0,000 0,0403091 0,09536542 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,0403091 0,09524316 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,0403091 0,09512121 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,0403091 0,09499957 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,0403091 0,09487824 ! ruffle organization GO:0031529 6 6 0,000 0,0403091 0,09475722 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,0403091 0,09463651 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,0403091 0,09451611 ! neutral amino acid transport GO:0015804 6 6 0,000 0,0403091 0,09439602 ! L-amino acid transport GO:0015807 6 6 0,000 0,0403091 0,09427622 ! bone mineralization GO:0030282 6 6 0,000 0,0403091 0,09415674 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,0403091 0,09403755 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,0403091 0,09391866 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,0403091 0,09380008 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,0403091 0,0936818 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,0403091 0,09356381 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,0403091 0,09344612 ! regulation of organ growth GO:0046620 6 6 0,000 0,0403091 0,09332872 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,0403091 0,09321162 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,0403091 0,09309482 ! response to dsRNA GO:0043331 6 6 0,000 0,0403091 0,0929783 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,0403091 0,09286208 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,0403091 0,09274615 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,0403091 0,0926305 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,0403091 0,09251515 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,0403091 0,09240008 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,0403091 0,0922853 ! multicellular organismal aging GO:0010259 6 6 0,000 0,0403091 0,0921708 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,0403091 0,09205658 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,0403091 0,09194265 ! erythrocyte development GO:0048821 6 6 0,000 0,0403091 0,091829 ! renal water homeostasis GO:0003091 6 6 0,000 0,0403091 0,09171563 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,0403091 0,09160254 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,0403091 0,09148973 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,0403091 0,0913772 ! ribosome assembly GO:0042255 6 6 0,000 0,0403091 0,09126494 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,0403091 0,09115296 ! diencephalon development GO:0021536 6 6 0,000 0,0403091 0,09104125 ! fucose catabolic process GO:0019317 6 6 0,000 0,0403091 0,09092982 GO:0042355|L-fucose catabolic process, ! protein sumoylation GO:0016925 6 6 0,000 0,0403091 0,09081866 ! regulation of lipid transport GO:0032368 6 6 0,000 0,0403091 0,09070777 ! regulation of cell division GO:0051302 6 6 0,000 0,0403091 0,09059715 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,0403091 0,0904868 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,0403091 0,09037672 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,0403091 0,09026691 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,0403091 0,09015736 ! neuroblast proliferation GO:0007405 6 6 0,000 0,0403091 0,09004808 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,0403091 0,08993906 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,0403091 0,08983031 ! regulation of glucose transport GO:0010827 6 6 0,000 0,0403091 0,08972182 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,0403091 0,08961359 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,0403091 0,08950562 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,0403091 0,08939791 ! lymph node development GO:0048535 6 6 0,000 0,0403091 0,08929046 ! organic cation transport GO:0015695 6 6 0,000 0,0403091 0,08918327 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,0403091 0,08907634 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,0403091 0,08896966 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,0403091 0,08886323 ! sperm-egg recognition GO:0035036 7 6 0,000 0,0403091 0,08875707 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,0403091 0,08865115 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,0403091 0,08854549 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,0403091 0,08844008 ! alditol metabolic process GO:0019400 6 6 0,000 0,0403091 0,08833492 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,0403091 0,08823 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,0403091 0,08812534 ! maternal placenta development GO:0001893 6 6 0,000 0,0403091 0,08802093 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,0403091 0,08791676 ! regulation of blood pressure GO:0008217 48 47 1,000 0,04064293 0,0885401 ! sex differentiation GO:0007548 47 47 1,000 0,04064293 0,08843557 ! rhythmic process GO:0048511 47 47 1,000 0,04064293 0,08833128 ! regulation of catabolic process GO:0009894 48 47 1,000 0,04064293 0,08822724 ! regulation of cell cycle process GO:0010564 50 48 1,000 0,04222882 0,09156202 ! protein localization in nucleus GO:0034504 48 48 1,000 0,04222882 0,09145443 ! ossification GO:0001503 50 49 1,000 0,04383779 0,09482751 GO:0060348|bone development, ! regulation of defense response GO:0031347 50 50 1,000 0,04546945 0,09824173 ! negative regulation of transport GO:0051051 51 50 1,000 0,04546945 0,09812669 ! chromatin assembly GO:0031497 50 50 1,000 0,04546945 0,09801193 GO:0006334|nucleosome assembly, ! anatomical structure homeostasis GO:0060249 51 50 1,000 0,04546945 0,09789743 ! anterior/posterior pattern formation GO:0009952 51 50 1,000 0,04546945 0,09778319 ! respiratory burst GO:0045730 7 7 0,000 0,04687085 0,10067945 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,04687085 0,10056225 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,04687085 0,10044531 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,04687085 0,10032865 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,04687085 0,10021226 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,04687085 0,10009614 ! regulation of chemokine production GO:0032642 7 7 0,000 0,04687085 0,09998029 ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,04687085 0,09986471 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,04687085 0,09974939 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,04687085 0,09963434 GO:0043241|protein complex disassembly, ! gene silencing by RNA GO:0031047 7 7 0,000 0,04687085 0,09951955 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,04687085 0,09940503 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,04687085 0,09929077 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,04687085 0,09917677 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,04687085 0,09906304 ! axis specification GO:0009798 7 7 0,000 0,04687085 0,09894956 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,04687085 0,09883635 ! visual behavior GO:0007632 7 7 0,000 0,04687085 0,09872339 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,04687085 0,0986107 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,04687085 0,09849826 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,04687085 0,09838607 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,04687085 0,09827414 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,04687085 0,09816247 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,04687085 0,09805104 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,04687085 0,09793988 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,04687085 0,09782896 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,04687085 0,09771829 ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,04687085 0,09760788 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,04687085 0,09749771 ! protein targeting to ER GO:0045047 8 7 0,000 0,04687085 0,09738779 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,04687085 0,09727812 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,04687085 0,0971687 ! endoderm development GO:0007492 7 7 0,000 0,04687085 0,09705952 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,04687085 0,09695058 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,04687085 0,09684189 GO:0006688|glycosphingolipid biosynthetic process, ! regulation of mRNA processing GO:0050684 7 7 0,000 0,04687085 0,09673345 ! response to hexose stimulus GO:0009746 7 7 0,000 0,04687085 0,09662525 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,04687085 0,09651728 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,04687085 0,09640956 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,04687085 0,09630208 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,04687085 0,09619484 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,04687085 0,09608784 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,04687085 0,09598108 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,04687085 0,09587455 ! UV protection GO:0009650 7 7 0,000 0,04687085 0,09576826 ! DNA integration GO:0015074 7 7 0,000 0,04687085 0,0956622 ! myofibril assembly GO:0030239 7 7 0,000 0,04687085 0,09555638 GO:0055002|striated muscle cell development, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,04687085 0,0954508 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,04687085 0,09534544 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,04687085 0,09524032 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,04687085 0,09513543 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,04687085 0,09503077 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,04687085 0,09492634 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,04687085 0,09482214 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,04687085 0,09471817 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,04687085 0,09461442 ! axon cargo transport GO:0008088 7 7 0,000 0,04687085 0,09451091 ! eating behavior GO:0042755 7 7 0,000 0,04687085 0,09440762 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,04687085 0,09430455 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,04687085 0,09420171 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,04687085 0,0940991 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,04687085 0,0939967 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,04687085 0,09389453 ! cranial nerve development GO:0021545 7 7 0,000 0,04687085 0,09379258 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,04687085 0,09369086 ! induction of an organ GO:0001759 7 7 0,000 0,04687085 0,09358935 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,04687085 0,09348806 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,04687085 0,09338699 ! autonomic nervous system development GO:0048483 7 7 0,000 0,04687085 0,09328614 ! intracellular lipid transport GO:0032365 7 7 0,000 0,04687085 0,09318551 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,04687085 0,0930851 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,04687085 0,0929849 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,04687085 0,09288491 ! natural killer cell activation GO:0030101 7 7 0,000 0,04687085 0,09278515 ! NADP metabolic process GO:0006739 7 7 0,000 0,04687085 0,09268559 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,04687085 0,09258625 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,04687085 0,09248712 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,04687085 0,0923882 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,04687085 0,0922895 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,04687085 0,092191 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,04687085 0,09209272 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,04687085 0,09199464 ! cell-cell recognition GO:0009988 8 7 0,000 0,04687085 0,09189678 ! hormone catabolic process GO:0042447 7 7 0,000 0,04687085 0,09179912 ! dopamine metabolic process GO:0042417 7 7 0,000 0,04687085 0,09170167 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,04687085 0,09160442 ! oxygen transport GO:0015671 7 7 0,000 0,04687085 0,09150738 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,04687085 0,09141055 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,04687085 0,09131392 ! regulation of axon extension GO:0030516 7 7 0,000 0,04687085 0,0912175 ! cell killing GO:0001906 7 7 0,000 0,04687085 0,09112128 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,04687085 0,09102526 ! adult feeding behavior GO:0008343 7 7 0,000 0,04687085 0,09092944 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,04687085 0,09083383 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,04687085 0,09073841 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,04687085 0,0906432 ! response to cold GO:0009409 7 7 0,000 0,04687085 0,09054819 ! protein-DNA complex assembly GO:0065004 51 51 1,000 0,04712344 0,09094084 ! carbohydrate catabolic process GO:0016052 53 53 1,000 0,05049696 0,09734926 ! regulation of T cell activation GO:0050863 53 53 1,000 0,05049696 0,09724753 ! regulation of protein transport GO:0051223 53 53 1,000 0,05049696 0,09714602 GO:0070201|regulation of establishment of protein localization, ! response to virus GO:0009615 54 54 1,000 0,05221575 0,1003479 ! hormone metabolic process GO:0042445 55 54 1,000 0,05221575 0,10024337 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,05338868 0,10238849 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,05338868 0,10228206 ! positive regulation of translation GO:0045727 8 8 0,000 0,05338868 0,10217584 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,05338868 0,10206985 ! superoxide anion generation GO:0042554 8 8 0,000 0,05338868 0,10196408 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,05338868 0,10185853 ! cGMP metabolic process GO:0046068 8 8 0,000 0,05338868 0,10175319 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,05338868 0,10164808 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,05338868 0,10154318 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,05338868 0,10143849 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,05338868 0,10133402 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,05338868 0,10122977 ! zinc ion transport GO:0006829 8 8 0,000 0,05338868 0,10112573 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,05338868 0,10102191 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,05338868 0,10091829 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,05338868 0,10081489 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,05338868 0,10071171 ! lipid localization GO:0010876 8 8 0,000 0,05338868 0,10060873 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,05338868 0,10050596 ! response to cAMP GO:0051591 8 8 0,000 0,05338868 0,10040341 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,05338868 0,10030106 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,05338868 0,10019892 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,05338868 0,10009699 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,05338868 0,09999526 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,05338868 0,09989374 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,05338868 0,09979243 ! sensory perception of taste GO:0050909 8 8 0,000 0,05338868 0,09969132 ! organelle fusion GO:0048284 8 8 0,000 0,05338868 0,09959042 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,05338868 0,09948972 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,05338868 0,09938923 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,05338868 0,09928894 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,05338868 0,09918885 ! sperm motility GO:0030317 8 8 0,000 0,05338868 0,09908896 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,05338868 0,09898927 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,05338868 0,09888979 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,05338868 0,0987905 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,05338868 0,09869141 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,05338868 0,09859252 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,05338868 0,09849383 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,05338868 0,09839534 ! Golgi organization GO:0007030 8 8 0,000 0,05338868 0,09829704 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,05338868 0,09819894 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,05338868 0,09810103 ! fructose metabolic process GO:0006000 8 8 0,000 0,05338868 0,09800332 ! mannose metabolic process GO:0006013 9 8 0,000 0,05338868 0,09790581 ! NAD metabolic process GO:0019674 8 8 0,000 0,05338868 0,09780849 ! plasma membrane fusion GO:0045026 8 8 0,000 0,05338868 0,09771136 ! response to fungus GO:0009620 8 8 0,000 0,05338868 0,09761442 ! stem cell differentiation GO:0048863 8 8 0,000 0,05338868 0,09751768 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,05338868 0,09742113 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,05338868 0,09732476 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,05338868 0,09722859 ! regulation of vasodilation GO:0042312 8 8 0,000 0,05338868 0,09713261 ! vasoconstriction GO:0042310 8 8 0,000 0,05338868 0,09703682 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,05338868 0,09694122 ! muscle cell development GO:0055001 8 8 0,000 0,05338868 0,0968458 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,05338868 0,09675058 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,05338868 0,09665554 ! sensory perception of pain GO:0019233 8 8 0,000 0,05338868 0,09656068 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,05338868 0,09646602 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,05338868 0,09637154 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,05338868 0,09627724 ! chromatin silencing GO:0006342 8 8 0,000 0,05338868 0,09618313 ! tissue regeneration GO:0042246 8 8 0,000 0,05338868 0,0960892 ! salivary gland development GO:0007431 8 8 0,000 0,05338868 0,09599545 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,05338868 0,09590189 ! water homeostasis GO:0030104 8 8 0,000 0,05338868 0,09580851 ! cofactor transport GO:0051181 8 8 0,000 0,05338868 0,09571531 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,05338868 0,09562229 ! acid secretion GO:0046717 8 8 0,000 0,05338868 0,09552945 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,05338868 0,0954368 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,05338868 0,09534432 ! regulation of immunoglobulin production GO:0002637 8 8 0,000 0,05338868 0,09525202 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,05338868 0,0951599 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,05338868 0,09506796 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,05338868 0,09497619 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,05338868 0,09488461 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,05338868 0,0947932 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,05338868 0,09470196 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,05338868 0,0946109 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,05338868 0,09452002 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,05338868 0,09442931 ! developmental induction GO:0031128 8 8 0,000 0,05338868 0,09433877 GO:0045168|cell-cell signaling involved in cell fate specification, ! peptide hormone secretion GO:0030072 8 8 0,000 0,05338868 0,09424841 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,05338868 0,09415822 ! actin filament polymerization GO:0030041 9 8 0,000 0,05338868 0,0940682 ! cytoplasmic sequestering of protein GO:0051220 8 8 0,000 0,05338868 0,09397835 ! peptide hormone processing GO:0016486 8 8 0,000 0,05338868 0,09388868 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,05338868 0,09379918 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,05338868 0,09370985 ! nucleosome organization GO:0034728 55 55 1,000 0,05395544 0,09461453 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 0,05395544 0,09452459 ! in utero embryonic development GO:0001701 55 55 1,000 0,05395544 0,09443482 ! extracellular structure organization GO:0043062 56 56 1,000 0,05571565 0,0974231 ! innate immune response GO:0045087 58 58 1,000 0,05929629 0,10358585 ! lactation GO:0007595 10 9 0,000 0,05986288 0,10447661 ! embryonic pattern specification GO:0009880 10 9 0,000 0,05986288 0,10437776 ! positive regulation of cell size GO:0045793 9 9 0,000 0,05986288 0,10427911 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,05986288 0,10418064 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,05986288 0,10408235 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,05986288 0,10398426 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,05986288 0,10388634 ! viral genome replication GO:0019079 9 9 0,000 0,05986288 0,10378861 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,05986288 0,10369107 ! copper ion transport GO:0006825 9 9 0,000 0,05986288 0,10359371 ! lipid phosphorylation GO:0046834 9 9 0,000 0,05986288 0,10349653 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,05986288 0,10339953 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,05986288 0,10330271 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,05986288 0,10320608 ! RNA polyadenylation GO:0043631 9 9 0,000 0,05986288 0,10310962 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,05986288 0,10301335 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,05986288 0,10291725 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,05986288 0,10282134 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,05986288 0,1027256 ! phospholipid efflux GO:0033700 9 9 0,000 0,05986288 0,10263004 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,05986288 0,10253466 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,05986288 0,10243946 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,05986288 0,10234443 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,05986288 0,10224958 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,05986288 0,1021549 ! methionine metabolic process GO:0006555 9 9 0,000 0,05986288 0,1020604 ! glutamine metabolic process GO:0006541 9 9 0,000 0,05986288 0,10196608 ! cerebral cortex development GO:0021987 9 9 0,000 0,05986288 0,10187193 ! pigmentation during development GO:0048066 9 9 0,000 0,05986288 0,10177795 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,05986288 0,10168414 ! central nervous system neuron development GO:0021954 10 9 0,000 0,05986288 0,10159051 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,05986288 0,10149705 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,05986288 0,10140376 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,05986288 0,10131065 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,05986288 0,1012177 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,05986288 0,10112493 ! L-glutamate transport GO:0015813 9 9 0,000 0,05986288 0,10103232 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,05986288 0,10093989 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,05986288 0,10084762 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,05986288 0,10075552 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,05986288 0,10066359 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,05986288 0,10057183 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,05986288 0,10048023 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,05986288 0,1003888 ! positive regulation of protein import into nucleus GO:0042307 9 9 0,000 0,05986288 0,10029754 ! DNA replication initiation GO:0006270 9 9 0,000 0,05986288 0,10020644 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,05986288 0,10011551 GO:0006692|prostanoid metabolic process, ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,05986288 0,10002475 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,05986288 0,09993414 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,05986288 0,09984371 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,05986288 0,09975343 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,05986288 0,09966332 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,05986288 0,09957337 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,05986288 0,09948359 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,05986288 0,09939396 ! collagen catabolic process GO:0030574 9 9 0,000 0,05986288 0,0993045 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,05986288 0,09921519 ! purine base metabolic process GO:0006144 9 9 0,000 0,05986288 0,09912605 ! gas transport GO:0015669 9 9 0,000 0,05986288 0,09903707 ! cholesterol efflux GO:0033344 9 9 0,000 0,05986288 0,09894825 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,05986288 0,09885958 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,05986288 0,09877108 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,05986288 0,09868273 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,05986288 0,09859454 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,05986288 0,09850651 ! actin filament-based movement GO:0030048 9 9 0,000 0,05986288 0,09841864 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,05986288 0,09833092 ! carboxylic acid transport GO:0046942 59 59 1,000 0,06111604 0,10029996 GO:0015849|organic acid transport, ! sterol metabolic process GO:0016125 59 59 1,000 0,06111604 0,10021073 ! protein localization in organelle GO:0033365 59 59 1,000 0,06111604 0,10012165 ! immune effector process GO:0002252 59 59 1,000 0,06111604 0,10003273 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 1,000 0,06295494 0,10295116 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,06629375 0,10831505 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,06629375 0,10821911 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 0,000 0,06629375 0,10812334 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,06629375 0,10802774 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,06629375 0,10793231 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,06629375 0,10783705 ! neuron maturation GO:0042551 10 10 0,000 0,06629375 0,10774195 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,06629375 0,10764702 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,06629375 0,10755226 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,06629375 0,10745767 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,06629375 0,10736324 ! hormone secretion GO:0046879 10 10 0,000 0,06629375 0,10726898 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,06629375 0,10717489 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,06629375 0,10708096 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 0,000 0,06629375 0,10698719 ! cAMP metabolic process GO:0046058 10 10 0,000 0,06629375 0,10689359 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,06629375 0,10680015 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,06629375 0,10670688 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,06629375 0,10661376 ! glial cell development GO:0021782 10 10 0,000 0,06629375 0,10652081 ! phototransduction GO:0007602 11 10 0,000 0,06629375 0,10642802 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,06629375 0,1063354 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,06629375 0,10624293 ! myoblast differentiation GO:0045445 10 10 0,000 0,06629375 0,10615063 ! centrosome cycle GO:0007098 10 10 0,000 0,06629375 0,10605848 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,06629375 0,1059665 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,06629375 0,10587467 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,06629375 0,10578301 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,06629375 0,1056915 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,06629375 0,10560015 ! protein polyubiquitination GO:0000209 10 10 0,000 0,06629375 0,10550896 ! glutamate metabolic process GO:0006536 11 10 0,000 0,06629375 0,10541792 ! plasma membrane organization GO:0007009 10 10 0,000 0,06629375 0,10532705 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,06629375 0,10523632 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,06629375 0,10514576 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,06629375 0,10505535 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,06629375 0,1049651 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,06629375 0,104875 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,06629375 0,10478505 ! exocrine system development GO:0035272 10 10 0,000 0,06629375 0,10469526 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,06629375 0,10460563 ! embryo implantation GO:0007566 11 10 0,000 0,06629375 0,10451614 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,06629375 0,10442681 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,06629375 0,10433764 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,06629375 0,10424861 ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,06629375 0,10415974 ! protein export from nucleus GO:0006611 10 10 0,000 0,06629375 0,10407102 ! negative regulation of immune response GO:0050777 10 10 0,000 0,06629375 0,10398244 ! cytolysis GO:0019835 10 10 0,000 0,06629375 0,10389402 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,06629375 0,10380575 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,06629375 0,10371763 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,06629375 0,10362966 ! histone deacetylation GO:0016575 10 10 0,000 0,06629375 0,10354184 ! mRNA splice site selection GO:0006376 11 10 0,000 0,06629375 0,10345417 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,06629375 0,10336664 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,06629375 0,10327927 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,06629375 0,10319204 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,06629375 0,10310496 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,06629375 0,10301802 ! regulation of epidermis development GO:0045682 10 10 0,000 0,06629375 0,10293123 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,06629375 0,10284459 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,06629375 0,10275809 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,06629375 0,10267174 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,06629375 0,10258554 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,06629375 0,10249947 ! nerve development GO:0021675 10 10 0,000 0,06629375 0,10241356 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,06629375 0,10232778 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,06629375 0,10224215 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,06629375 0,10215667 ! protein stabilization GO:0050821 10 10 0,000 0,06629375 0,10207132 ! lipid transport GO:0006869 62 62 1,000 0,06668891 0,10259403 ! protein import GO:0017038 62 62 1,000 0,06668891 0,10250847 ! regulation of lymphocyte activation GO:0051249 62 62 1,000 0,06668891 0,10242304 ! regulation of secretion GO:0051046 65 63 1,000 0,06858331 0,10524483 ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,06858331 0,10515727 ! glucose metabolic process GO:0006006 63 63 1,000 0,06858331 0,10506986 ! glycerolipid metabolic process GO:0046486 65 64 1,000 0,07049556 0,10790973 ! positive regulation of cellular component organization GO:0051130 65 65 1,000 0,07242534 0,1107717 ! regulation of hormone levels GO:0010817 66 65 1,000 0,07242534 0,11067985 ! protein secretion GO:0009306 11 11 0,000 0,07268155 0,11097936 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,07268155 0,11088749 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,07268155 0,11079577 ! negative regulation of defense response GO:0031348 11 11 0,000 0,07268155 0,11070421 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,07268155 0,11061279 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,07268155 0,11052153 ! skin development GO:0043588 11 11 0,000 0,07268155 0,11043041 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,07268155 0,11033945 ! signal complex assembly GO:0007172 11 11 0,000 0,07268155 0,11024863 ! microtubule-based transport GO:0010970 11 11 0,000 0,07268155 0,11015797 ! endothelial cell migration GO:0043542 11 11 0,000 0,07268155 0,11006745 ! peroxisomal transport GO:0043574 11 11 0,000 0,07268155 0,10997709 ! protein amino acid methylation GO:0006479 11 11 0,000 0,07268155 0,10988687 GO:0008213|protein amino acid alkylation, ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 0,000 0,07268155 0,10979679 GO:0032388|positive regulation of intracellular transport, ! heart contraction GO:0060047 11 11 0,000 0,07268155 0,10970687 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,07268155 0,10961709 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,07268155 0,10952747 ! T cell proliferation GO:0042098 11 11 0,000 0,07268155 0,10943798 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,07268155 0,10934864 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,07268155 0,10925945 ! spinal cord development GO:0021510 11 11 0,000 0,07268155 0,10917041 ! smooth muscle contraction GO:0006939 11 11 0,000 0,07268155 0,10908151 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,07268155 0,10899275 ! digestive system process GO:0022600 11 11 0,000 0,07268155 0,10890414 ! mitotic spindle organization GO:0007052 11 11 0,000 0,07268155 0,10881567 ! fucose metabolic process GO:0006004 11 11 0,000 0,07268155 0,10872735 ! membrane budding GO:0006900 11 11 0,000 0,07268155 0,10863916 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,07268155 0,10855113 ! monoamine transport GO:0015844 11 11 0,000 0,07268155 0,10846323 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,07268155 0,10837548 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,07268155 0,10828787 ! body fluid secretion GO:0007589 11 11 0,000 0,07268155 0,1082004 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 0,000 0,07268155 0,10811307 ! intermediate filament-based process GO:0045103 11 11 0,000 0,07268155 0,10802588 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,07268155 0,10793883 GO:0060415|muscle tissue morphogenesis, ! membrane depolarization GO:0051899 11 11 0,000 0,07268155 0,10785192 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,07268155 0,10776516 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,07268155 0,10767853 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,07268155 0,10759204 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,07268155 0,10750569 ! vitamin transport GO:0051180 11 11 0,000 0,07268155 0,10741948 ! muscle maintenance GO:0046716 12 11 0,000 0,07268155 0,10733341 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,07268155 0,10724747 ! steroid catabolic process GO:0006706 11 11 0,000 0,07268155 0,10716167 ! endocrine process GO:0050886 11 11 0,000 0,07268155 0,10707601 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,07268155 0,10699049 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,07268155 0,1069051 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,07268155 0,10681985 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,07268155 0,10673473 ! DNA packaging GO:0006323 66 66 1,000 0,07437233 0,10913073 ! negative regulation of protein metabolic process GO:0051248 66 66 1,000 0,07437233 0,10904391 ! chromatin assembly or disassembly GO:0006333 68 68 1,000 0,07831669 0,11473582 ! positive regulation of protein catabolic process GO:0045732 12 12 0,000 0,07902657 0,11568385 ! translational initiation GO:0006413 12 12 0,000 0,07902657 0,11559204 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,07902657 0,11550037 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,07902657 0,11540885 ! initiation of viral infection GO:0019059 12 12 0,000 0,07902657 0,11531747 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,07902657 0,11522624 ! iron ion transport GO:0006826 13 12 0,000 0,07902657 0,11513515 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,07902657 0,11504421 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,07902657 0,11495341 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,07902657 0,11486275 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,07902657 0,11477224 ! collagen metabolic process GO:0032963 12 12 0,000 0,07902657 0,11468186 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,07902657 0,11459164 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,07902657 0,11450155 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,07902657 0,1144116 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,07902657 0,1143218 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,07902657 0,11423213 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,07902657 0,11414261 ! actomyosin structure organization GO:0031032 12 12 0,000 0,07902657 0,11405323 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,07902657 0,11396398 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,07902657 0,11387488 ! retinoid metabolic process GO:0001523 12 12 0,000 0,07902657 0,11378591 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,07902657 0,11369709 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,07902657 0,1136084 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,07902657 0,11351985 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,07902657 0,11343144 ! acute-phase response GO:0006953 12 12 0,000 0,07902657 0,11334317 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,07902657 0,11325503 ! vacuolar transport GO:0007034 12 12 0,000 0,07902657 0,11316703 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,07902657 0,11307917 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,07902657 0,11299144 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,07902657 0,11290385 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,07902657 0,1128164 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,07902657 0,11272908 ! regulation of alpha-beta T cell activation GO:0046634 12 12 0,000 0,07902657 0,11264189 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,07902657 0,11255484 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,07902657 0,11246793 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,07902657 0,11238115 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,07902657 0,1122945 ! pallium development GO:0021543 13 12 0,000 0,07902657 0,11220799 ! cell fate determination GO:0001709 12 12 0,000 0,07902657 0,11212161 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,07902657 0,11203536 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,07902657 0,11194925 ! detection of light stimulus GO:0009583 13 12 0,000 0,07902657 0,11186326 ! synaptogenesis GO:0007416 12 12 0,000 0,07902657 0,11177741 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,07902657 0,11169169 ! hormone transport GO:0009914 12 12 0,000 0,07902657 0,11160611 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,07902657 0,11152065 ! heme biosynthetic process GO:0006783 12 12 0,000 0,07902657 0,11143532 ! spermatid differentiation GO:0048515 13 12 0,000 0,07902657 0,11135013 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,07902657 0,11126506 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,07902657 0,11118013 ! neural tube closure GO:0001843 13 12 0,000 0,07902657 0,11109532 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 0,000 0,07902657 0,11101065 ! regulation of translation GO:0006417 69 69 1,000 0,08031345 0,11273243 ! sensory perception of sound GO:0007605 71 69 1,000 0,08031345 0,11264664 GO:0050954|sensory perception of mechanical stimulus, ! regionalization GO:0003002 70 69 1,000 0,08031345 0,11256098 ! regulation of leukocyte activation GO:0002694 69 69 1,000 0,08031345 0,11247544 ! positive regulation of transport GO:0051050 71 70 1,000 0,08232618 0,11520665 ! calcium ion homeostasis GO:0055074 71 71 1,000 0,08435459 0,11795563 GO:0006874|cellular calcium ion homeostasis, ! negative regulation of signal transduction GO:0009968 71 71 1,000 0,08435459 0,1178662 ! regulation of cell activation GO:0050865 71 71 1,000 0,08435459 0,11777691 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,0853291 0,11904733 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,0853291 0,11895728 ! phenol metabolic process GO:0018958 13 13 0,000 0,0853291 0,11886737 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! gluconeogenesis GO:0006094 13 13 0,000 0,0853291 0,11877759 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,0853291 0,11868794 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,0853291 0,11859843 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,0853291 0,11850906 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,0853291 0,11841982 ! keratinization GO:0031424 13 13 0,000 0,0853291 0,11833072 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,0853291 0,11824175 ! patterning of blood vessels GO:0001569 13 13 0,000 0,0853291 0,11815291 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,0853291 0,11806421 ! regulation of innate immune response GO:0045088 13 13 0,000 0,0853291 0,11797564 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,0853291 0,1178872 ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,0853291 0,11779889 ! autophagy GO:0006914 13 13 0,000 0,0853291 0,11771072 ! negative regulation of protein catabolic process GO:0042177 13 13 0,000 0,0853291 0,11762268 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,0853291 0,11753477 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,0853291 0,11744699 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,0853291 0,11735935 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! nucleobase metabolic process GO:0009112 13 13 0,000 0,0853291 0,11727183 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,0853291 0,11718444 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,0853291 0,11709719 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,0853291 0,11701006 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,0853291 0,11692307 ! vasodilation GO:0042311 14 13 0,000 0,0853291 0,1168362 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,0853291 0,11674946 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 0,000 0,0853291 0,11666285 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,0853291 0,11657637 GO:0006664|glycolipid metabolic process, ! neural crest cell migration GO:0001755 14 13 0,000 0,0853291 0,11649002 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,0853291 0,11640379 ! immunoglobulin production GO:0002377 13 13 0,000 0,0853291 0,1163177 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,0853291 0,11623173 ! negative regulation of intracellular transport GO:0032387 13 13 0,000 0,0853291 0,11614588 ! cell-cell junction organization GO:0045216 13 13 0,000 0,0853291 0,11606017 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,0853291 0,11597458 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,0853291 0,11588911 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,0853291 0,11580377 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,0853291 0,11571856 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,0853291 0,11563347 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,0853291 0,11554851 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,0853291 0,11546367 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,0853291 0,11537896 ! blastocyst development GO:0001824 13 13 0,000 0,0853291 0,11529437 ! telomere organization GO:0032200 13 13 0,000 0,0853291 0,11520991 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,0853291 0,11512557 ! regulation of amine transport GO:0051952 13 13 0,000 0,0853291 0,11504135 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,0853291 0,11495725 ! secretion by cell GO:0032940 75 72 1,000 0,08639839 0,1163128 ! sensory organ development GO:0007423 72 72 1,000 0,08639839 0,1162279 ! neuron fate commitment GO:0048663 14 14 0,000 0,0915894 0,12312128 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,0915894 0,12303154 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,0915894 0,12294193 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,0915894 0,12285245 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,0915894 0,12276311 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,0915894 0,12267389 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,0915894 0,1225848 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,0915894 0,12249584 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,0915894 0,12240701 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,0915894 0,12231831 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,0915894 0,12222974 ! vesicle docking GO:0048278 14 14 0,000 0,0915894 0,1221413 ! superoxide metabolic process GO:0006801 15 14 0,000 0,0915894 0,12205298 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,0915894 0,12196479 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,0915894 0,12187673 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,0915894 0,1217888 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,0915894 0,12170099 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,0915894 0,12161331 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to retinoic acid GO:0032526 14 14 0,000 0,0915894 0,12152575 GO:0033189|response to vitamin A, ! lysosome organization GO:0007040 14 14 0,000 0,0915894 0,12143832 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,0915894 0,12135102 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,0915894 0,12126384 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 0,000 0,0915894 0,12117679 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 0,000 0,0915894 0,12108986 ! primary neural tube formation GO:0014020 15 14 0,000 0,0915894 0,12100306 ! peptide cross-linking GO:0018149 14 14 0,000 0,0915894 0,12091638 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,0915894 0,12082983 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,0915894 0,1207434 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,0915894 0,12065709 ! formation of primary germ layer GO:0001704 14 14 0,000 0,0915894 0,12057091 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,0915894 0,12048485 ! collagen fibril organization GO:0030199 14 14 0,000 0,0915894 0,12039891 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,0915894 0,12031309 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,0915894 0,1202274 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,0915894 0,12014183 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,0915894 0,12005638 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,0915894 0,11997105 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,0915894 0,11988585 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,0915894 0,11980076 ! negative regulation of cell communication GO:0010648 76 76 1,000 0,09472152 0,12380977 ! positive regulation of multicellular organismal process GO:0051240 76 76 1,000 0,09472152 0,12372202 ! cellular metal ion homeostasis GO:0006875 77 77 1,000 0,09683787 0,12639674 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,09780777 0,12757234 ! positive regulation of ossification GO:0045778 15 15 0,000 0,09780777 0,12748212 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,09780777 0,12739203 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,09780777 0,12730206 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,09780777 0,12721222 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,09780777 0,12712251 ! response to vitamin GO:0033273 15 15 0,000 0,09780777 0,12703292 ! regulation of transcription factor import into nucleus GO:0042990 15 15 0,000 0,09780777 0,12694346 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,09780777 0,12685413 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,09780777 0,12676492 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,09780777 0,12667584 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,09780777 0,12658688 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,09780777 0,12649805 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,09780777 0,12640934 ! heme metabolic process GO:0042168 15 15 0,000 0,09780777 0,12632076 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,09780777 0,1262323 ! chromosome condensation GO:0030261 15 15 0,000 0,09780777 0,12614396 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,09780777 0,12605575 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,09780777 0,12596766 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,09780777 0,12587969 GO:0030500|regulation of bone mineralization, ! regulation of production of molecular mediator of immune response GO:0002700 15 15 0,000 0,09780777 0,12579185 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,09780777 0,12570413 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,09780777 0,12561653 ! phospholipid transport GO:0015914 15 15 0,000 0,09780777 0,12552905 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,09780777 0,1254417 ! glutathione metabolic process GO:0006749 16 15 0,000 0,09780777 0,12535446 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,09780777 0,12526735 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 0,000 0,09780777 0,12518036 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,09780777 0,12509349 ! negative regulation of transcription factor activity GO:0043433 16 15 0,000 0,09780777 0,12500674 GO:0090048|negative regulation of transcription regulator activity, ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,09780777 0,12492011 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,09780777 0,1248336 ! metal ion homeostasis GO:0055065 78 78 1,000 0,09896788 0,12622685 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,10398447 0,13253345 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 0,000 0,10398447 0,13244186 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! alkaloid metabolic process GO:0009820 16 16 0,000 0,10398447 0,1323504 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,10398447 0,13225906 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,10398447 0,13216784 ! learning GO:0007612 16 16 0,000 0,10398447 0,13207676 ! circadian rhythm GO:0007623 16 16 0,000 0,10398447 0,1319858 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,10398447 0,13189496 ! vacuole organization GO:0007033 16 16 0,000 0,10398447 0,13180425 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,10398447 0,13171366 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,10398447 0,1316232 ! vesicle targeting GO:0006903 17 16 0,000 0,10398447 0,13153286 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,10398447 0,13144264 ! iron ion homeostasis GO:0055072 16 16 0,000 0,10398447 0,13135255 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,10398447 0,13126259 ! cell fate specification GO:0001708 16 16 0,000 0,10398447 0,13117274 ! pentose metabolic process GO:0019321 16 16 0,000 0,10398447 0,13108302 ! positive regulation of MAPKKK cascade GO:0043410 17 16 0,000 0,10398447 0,13099342 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 0,000 0,10398447 0,13090394 ! cofactor catabolic process GO:0051187 16 16 0,000 0,10398447 0,13081459 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,10398447 0,13072536 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,10398447 0,13063625 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,10398447 0,13054726 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,10398447 0,13045839 GO:0001841|neural tube formation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,10398447 0,13036964 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 0,000 0,11011977 0,13796787 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,11011977 0,13787414 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,11011977 0,13778054 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,11011977 0,13768707 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,11011977 0,13759372 ! leukocyte adhesion GO:0007159 17 17 0,000 0,11011977 0,1375005 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,11011977 0,13740741 ! sensory perception of smell GO:0007608 17 17 0,000 0,11011977 0,13731444 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,11011977 0,1372216 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,11011977 0,13712888 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,11011977 0,13703629 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,11011977 0,13694382 ! neural crest cell development GO:0014032 19 17 0,000 0,11011977 0,13685148 GO:0014033|neural crest cell differentiation, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,11011977 0,13675926 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,11011977 0,13666717 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,11011977 0,1365752 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,11011977 0,13648335 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,11011977 0,13639163 ! adult locomotory behavior GO:0008344 17 17 0,000 0,11011977 0,13630003 ! embryonic organ development GO:0048568 17 17 0,000 0,11011977 0,13620855 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,11011977 0,1361172 ! gene silencing GO:0016458 17 17 0,000 0,11011977 0,13602597 ! regulation of cellular localization GO:0060341 86 85 1,000 0,11423776 0,14101822 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,11621395 0,14336166 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,11621395 0,14326576 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,11621395 0,14317 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,11621395 0,14307436 ! membrane docking GO:0022406 18 18 0,000 0,11621395 0,14297885 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,11621395 0,14288347 ! response to calcium ion GO:0051592 18 18 0,000 0,11621395 0,14278821 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,11621395 0,14269308 ! striated muscle contraction GO:0006941 18 18 0,000 0,11621395 0,14259808 ! negative regulation of DNA binding GO:0043392 19 18 0,000 0,11621395 0,14250321 ! ceramide metabolic process GO:0006672 18 18 0,000 0,11621395 0,14240846 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,11621395 0,14231383 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,11621395 0,14221933 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,11621395 0,14212496 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,11621395 0,14203071 ! BMP signaling pathway GO:0030509 18 18 0,000 0,11621395 0,14193659 ! regulation of microtubule-based process GO:0032886 18 18 0,000 0,11621395 0,14184259 ! negative regulation of catabolic process GO:0009895 18 18 0,000 0,11621395 0,14174872 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,11621395 0,14165497 ! hexose metabolic process GO:0019318 87 86 1,000 0,11646741 0,14187008 ! male gamete generation GO:0048232 90 88 1,000 0,12096032 0,14724563 GO:0007283|spermatogenesis, ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,12226728 0,14873835 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,12226728 0,14864024 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 19 19 0,000 0,12226728 0,14854226 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,12226728 0,1484444 ! feeding behavior GO:0007631 19 19 0,000 0,12226728 0,14834668 ! peroxisome organization GO:0007031 19 19 0,000 0,12226728 0,14824908 ! positive regulation of T cell proliferation GO:0042102 19 19 0,000 0,12226728 0,14815161 ! multicellular organismal metabolic process GO:0044236 19 19 0,000 0,12226728 0,14805427 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,12226728 0,14795706 ! cellular response to oxidative stress GO:0034599 19 19 0,000 0,12226728 0,14785998 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,12226728 0,14776302 ! positive regulation of T cell differentiation GO:0045582 19 19 0,000 0,12226728 0,14766619 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,12226728 0,14756948 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,12226728 0,14747291 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,12226728 0,14737646 ! dorsal/ventral pattern formation GO:0009953 19 19 0,000 0,12226728 0,14728013 ! eye morphogenesis GO:0048592 19 19 0,000 0,12226728 0,14718393 ! vesicle localization GO:0051648 20 19 0,000 0,12226728 0,14708786 ! chemotaxis GO:0006935 90 89 1,000 0,1232231 0,14814101 GO:0042330|taxis, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 1,000 0,1232231 0,14804444 ! regulation of Ras protein signal transduction GO:0046578 90 90 1,000 0,12549641 0,15067745 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 1,000 0,12778004 0,15331941 ! DNA replication GO:0006260 91 91 1,000 0,12778004 0,15321966 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,12828003 0,15371917 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,12828003 0,15361929 ! negative regulation of binding GO:0051100 21 20 0,000 0,12828003 0,15351954 ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,12828003 0,15341992 ! neural tube development GO:0021915 21 20 0,000 0,12828003 0,15332042 ! nucleus organization GO:0006997 20 20 0,000 0,12828003 0,15322106 ! phagocytosis GO:0006909 21 20 0,000 0,12828003 0,15312182 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,12828003 0,15302271 ! protein targeting to membrane GO:0006612 22 20 0,000 0,12828003 0,15292373 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,12828003 0,15282488 ! chromatin remodeling GO:0006338 20 20 0,000 0,12828003 0,15272616 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,12828003 0,15262756 ! lipid oxidation GO:0034440 20 20 0,000 0,12828003 0,15252909 GO:0019395|fatty acid oxidation, ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,12828003 0,15243075 ! RNA modification GO:0009451 20 20 0,000 0,12828003 0,15233253 ! single fertilization GO:0007338 21 20 0,000 0,12828003 0,15223444 ! regulation of B cell activation GO:0050864 20 20 0,000 0,12828003 0,15213648 ! positive regulation of immune system process GO:0002684 92 92 1,000 0,13007374 0,15416456 ! mRNA catabolic process GO:0006402 21 21 0,000 0,13425245 0,15901496 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,13425245 0,15891283 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,13425245 0,15881083 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,13425245 0,15870896 ! Notch signaling pathway GO:0007219 22 21 0,000 0,13425245 0,15860723 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,13425245 0,15850562 ! ear morphogenesis GO:0042471 21 21 0,000 0,13425245 0,15840414 ! organic anion transport GO:0015711 21 21 0,000 0,13425245 0,1583028 ! cholesterol transport GO:0030301 21 21 0,000 0,13425245 0,15820158 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,13425245 0,15810049 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,13425245 0,15799953 GO:0032313|regulation of Rab GTPase activity, ! regulation of protein import into nucleus GO:0042306 21 21 0,000 0,13425245 0,15789871 ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,13425245 0,157798 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,13425245 0,15769743 ! regulation of proteolysis GO:0030162 21 21 0,000 0,13425245 0,15759699 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 0,000 0,13425245 0,15749667 ! negative regulation of protein transport GO:0051224 21 21 0,000 0,13425245 0,15739648 ! pattern specification process GO:0007389 96 94 1,000 0,13469039 0,15780953 ! epidermis development GO:0008544 94 94 1,000 0,13469039 0,15770927 ! RNA export from nucleus GO:0006405 22 22 0,000 0,14018482 0,1640385 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,14018482 0,16393441 ! regulation of ion transport GO:0043269 22 22 0,000 0,14018482 0,16383046 ! odontogenesis GO:0042476 22 22 0,000 0,14018482 0,16372664 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 0,000 0,14018482 0,16362295 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! embryonic skeletal system development GO:0048706 22 22 0,000 0,14018482 0,16351939 ! maintenance of protein location in cell GO:0032507 23 22 0,000 0,14018482 0,16341596 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,14018482 0,16331266 ! cell chemotaxis GO:0060326 23 22 0,000 0,14018482 0,1632095 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,14018482 0,16310646 ! biopolymer methylation GO:0043414 22 22 0,000 0,14018482 0,16300355 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 0,000 0,14018482 0,16290078 ! detection of external stimulus GO:0009581 23 22 0,000 0,14018482 0,16279813 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,14018482 0,16269561 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,14018482 0,16259322 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 0,000 0,14018482 0,16249096 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,14018482 0,16238883 ! aerobic respiration GO:0009060 22 22 0,000 0,14018482 0,16228683 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,14018482 0,16218495 ! viral infectious cycle GO:0019058 23 23 0,000 0,1460774 0,16889627 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,1460774 0,16879038 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,1460774 0,16868462 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,1460774 0,168579 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,1460774 0,1684735 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,1460774 0,16836814 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,1460774 0,16826291 ! ectoderm development GO:0007398 99 99 1,000 0,14639202 0,16851999 ! response to other organism GO:0051707 101 100 1,000 0,14875799 0,17113669 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,15193045 0,17467737 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,15193045 0,17456847 ! fertilization GO:0009566 25 24 0,000 0,15193045 0,17445971 ! maintenance of protein location GO:0045185 25 24 0,000 0,15193045 0,17435108 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,15193045 0,17424258 ! glucan metabolic process GO:0044042 25 24 0,000 0,15193045 0,17413422 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,15774423 0,18068528 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,15774423 0,18057306 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,15774423 0,18046097 ! cellular component disassembly GO:0022411 26 25 0,000 0,15774423 0,18034902 ! endosome transport GO:0016197 25 25 0,000 0,15774423 0,18023721 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,15774423 0,18012554 ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,15774423 0,18001401 ! excretion GO:0007588 25 25 0,000 0,15774423 0,17990261 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,15774423 0,17979136 ! gastrulation GO:0007369 25 25 0,000 0,15774423 0,17968024 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,15774423 0,17956925 ! regulation of endocytosis GO:0030100 25 25 0,000 0,15774423 0,17945841 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,15774423 0,1793477 ! positive regulation of cytokine production GO:0001819 25 25 0,000 0,15774423 0,17923713 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,163519 0,18568424 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 0,000 0,163519 0,1855699 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,163519 0,1854557 ! cellular defense response GO:0006968 26 26 0,000 0,163519 0,18534165 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,163519 0,18522773 ! regulation of protein secretion GO:0050708 26 26 0,000 0,163519 0,18511395 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,163519 0,18500032 GO:0035150|regulation of tube size, ! maintenance of location in cell GO:0051651 27 26 0,000 0,163519 0,18488682 ! chloride transport GO:0006821 27 27 0,000 0,16925501 0,19125505 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,16925501 0,19113786 ! energy reserve metabolic process GO:0006112 28 27 0,000 0,16925501 0,19102081 ! learning or memory GO:0007611 28 27 0,000 0,16925501 0,1909039 ! cAMP-mediated signaling GO:0019933 27 27 0,000 0,16925501 0,19078714 ! peptide metabolic process GO:0006518 29 27 0,000 0,16925501 0,19067053 ! inner ear development GO:0048839 27 27 0,000 0,16925501 0,19055405 ! defense response to bacterium GO:0042742 27 27 0,000 0,16925501 0,19043772 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,16925501 0,19032153 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,16925501 0,19020548 ! cell growth GO:0016049 27 27 0,000 0,16925501 0,19008957 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,17495252 0,19636875 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! neuromuscular process GO:0050905 28 28 0,000 0,17495252 0,19624923 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,17495252 0,19612986 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,17495252 0,19601063 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,17495252 0,19589155 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,17495252 0,19577261 ! cartilage development GO:0051216 29 28 0,000 0,17495252 0,19565381 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,18061177 0,20186022 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,18061177 0,20173788 ! leukocyte migration GO:0050900 30 29 0,000 0,18061177 0,20161569 ! antigen processing and presentation GO:0019882 29 29 0,000 0,18061177 0,20149364 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,18061177 0,20137175 ! tRNA processing GO:0008033 29 29 0,000 0,18061177 0,20125 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,18061177 0,2011284 ! adult behavior GO:0030534 30 29 0,000 0,18061177 0,20100694 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,18061177 0,20088563 ! positive regulation of protein transport GO:0051222 29 29 0,000 0,18061177 0,20076447 ! transition metal ion transport GO:0000041 31 30 0,000 0,18623303 0,20688817 ! RNA catabolic process GO:0006401 30 30 0,000 0,18623303 0,20676354 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,18623303 0,20663906 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,18623303 0,20651473 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,18623303 0,20639055 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,18623303 0,20626651 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,18623303 0,20614263 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,18623303 0,20601889 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,18623303 0,20589531 GO:0019724|B cell mediated immunity, ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,18623303 0,20577187 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,18623303 0,20564858 ! regulation of translational initiation GO:0006446 31 31 0,000 0,19181654 0,21168736 ! membrane fusion GO:0006944 31 31 0,000 0,19181654 0,21156067 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,19181654 0,21143414 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,19181654 0,21130776 ! ion transmembrane transport GO:0034220 31 31 0,000 0,19181654 0,21118153 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,19181654 0,21105546 ! digestion GO:0007586 31 31 0,000 0,19181654 0,21092953 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,19181654 0,21080375 ! regulation of heart contraction GO:0008016 31 31 0,000 0,19181654 0,21067812 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,19181654 0,21055264 ! camera-type eye development GO:0043010 31 31 0,000 0,19181654 0,21042731 ! extracellular matrix organization GO:0030198 31 31 0,000 0,19181654 0,21030213 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,19181654 0,2101771 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,19181654 0,21005222 ! cell redox homeostasis GO:0045454 32 32 0,000 0,19736255 0,21599714 ! lipid modification GO:0030258 32 32 0,000 0,19736255 0,21586895 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,19736255 0,21574092 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,19736255 0,21561303 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,19736255 0,2154853 ! maintenance of location GO:0051235 33 32 0,000 0,19736255 0,21535772 ! amino acid transport GO:0006865 33 33 0,000 0,20287131 0,22123776 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,20287131 0,22110693 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,20287131 0,22097625 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,20287131 0,22084573 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,20287131 0,22071536 ! regulation of actin filament length GO:0030832 34 34 0,000 0,20834305 0,22653466 ! cellular polysaccharide metabolic process GO:0044264 35 34 0,000 0,20834305 0,22640109 ! regulation of protein catabolic process GO:0042176 35 34 0,000 0,20834305 0,22626768 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,20834305 0,22613442 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,20834305 0,22600132 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,20834305 0,22586838 ! detection of stimulus GO:0051606 36 34 0,000 0,20834305 0,2257356 ! acute inflammatory response GO:0002526 35 35 0,000 0,21377804 0,2314882 ! regulation of cellular component size GO:0032535 35 35 0,000 0,21377804 0,23135227 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,21377804 0,2312165 ! mesoderm development GO:0007498 35 35 0,000 0,21377804 0,23108089 ! inorganic anion transport GO:0015698 35 35 0,000 0,21377804 0,23094544 ! regulation of immune effector process GO:0002697 35 35 0,000 0,21377804 0,23081015 ! hydrogen transport GO:0006818 36 36 0,000 0,21917649 0,23650016 GO:0015992|proton transport, ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,21917649 0,23636178 ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,21917649 0,23622355 GO:0035113|embryonic appendage morphogenesis, ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,21917649 0,23608549 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,21917649 0,23594759 ! integrin-mediated signaling pathway GO:0007229 36 36 0,000 0,21917649 0,23580985 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,21917649 0,23567227 ! activation of immune response GO:0002253 36 36 0,000 0,21917649 0,23553485 ! regulation of adenylate cyclase activity GO:0045761 37 37 0,000 0,22453866 0,24115662 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,22453866 0,24101617 ! eye development GO:0001654 37 37 0,000 0,22453866 0,24087588 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,22453866 0,24073575 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,22453866 0,24059579 ! neurotransmitter transport GO:0006836 40 38 0,000 0,22986479 0,24615968 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,22986479 0,24601673 ! RNA elongation GO:0006354 38 38 0,000 0,22986479 0,24587395 ! regulation of neurological system process GO:0031644 38 38 0,000 0,22986479 0,24573133 ! regulation of cAMP biosynthetic process GO:0030817 39 39 0,000 0,23515511 0,25124108 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,23515511 0,25109552 ! response to unfolded protein GO:0006986 39 39 0,000 0,23515511 0,25095012 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,23515511 0,2508049 ! cytokine-mediated signaling pathway GO:0019221 39 39 0,000 0,23515511 0,25065984 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,23515511 0,25051495 ! positive regulation of T cell activation GO:0050870 39 39 0,000 0,23515511 0,25037023 ! limb development GO:0060173 39 39 0,000 0,23515511 0,25022567 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! regulation of cAMP metabolic process GO:0030814 40 40 0,000 0,24040985 0,25566957 ! DNA catabolic process GO:0006308 41 40 0,000 0,24040985 0,25552212 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 0,000 0,24562926 0,26091915 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! amine catabolic process GO:0009310 42 41 0,000 0,24562926 0,26076885 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,24562926 0,26061872 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,24562926 0,26046877 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,24562926 0,26031899 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,24562926 0,26016938 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,25081356 0,26550798 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 0,000 0,25081356 0,26535556 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,25081356 0,26520332 ! protein ubiquitination GO:0016567 43 42 0,000 0,25081356 0,26505125 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,25081356 0,26489936 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! one-carbon metabolic process GO:0006730 42 42 0,000 0,25081356 0,26474764 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 0,000 0,25081356 0,2645961 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 0,000 0,25596298 0,26987401 ! regulation of nucleotide metabolic process GO:0006140 43 43 0,000 0,25596298 0,26971971 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 0,000 0,26107776 0,27495218 ! mRNA transport GO:0051028 44 44 0,000 0,26107776 0,27479515 ! vitamin metabolic process GO:0006766 44 44 0,000 0,26107776 0,27463831 ! positive regulation of lymphocyte activation GO:0051251 44 44 0,000 0,26107776 0,27448164 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,26615812 0,27966329 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 0,000 0,26615812 0,27950394 ! protein processing GO:0016485 45 45 0,000 0,26615812 0,27934477 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,27120429 0,28447895 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 0,000 0,27120429 0,28431713 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 0,000 0,27120429 0,28415549 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,27120429 0,28399404 ! positive regulation of ligase activity GO:0051351 47 46 0,000 0,27120429 0,28383277 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,27621649 0,2889143 ! amine transport GO:0015837 47 47 0,000 0,27621649 0,28875042 ! calcium ion transport GO:0006816 48 48 0,000 0,28119496 0,29378815 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 0,000 0,28119496 0,2936217 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,28119496 0,29345544 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,2861399 0,29844699 ! divalent metal ion transport GO:0070838 49 49 0,000 0,2861399 0,29827818 ! response to bacterium GO:0009617 50 49 0,000 0,2861399 0,29810957 ! regulation of ligase activity GO:0051340 50 49 0,000 0,2861399 0,29794115 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,2861399 0,29777291 ! positive regulation of cell activation GO:0050867 49 49 0,000 0,2861399 0,29760487 GO:0002696|positive regulation of leukocyte activation, ! RNA transport GO:0050658 50 50 0,000 0,29105154 0,30254257 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 0,000 0,29105154 0,30237203 ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,29105154 0,30220168 ! transcription initiation GO:0006352 50 50 0,000 0,29105154 0,30203152 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,2959301 0,30692131 ! protein modification by small protein conjugation GO:0032446 52 51 0,000 0,2959301 0,30674869 ! positive regulation of immune response GO:0050778 51 51 0,000 0,2959301 0,30657626 ! rRNA metabolic process GO:0016072 51 51 0,000 0,2959301 0,30640403 GO:0006364|rRNA processing, ! ATP biosynthetic process GO:0006754 51 51 0,000 0,2959301 0,30623199 ! protein maturation GO:0051604 51 51 0,000 0,2959301 0,30606014 ! RNA localization GO:0006403 52 52 0,000 0,3007758 0,31089725 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,3007758 0,31072298 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 0,000 0,3007758 0,31054891 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,3007758 0,31037503 ! sodium ion transport GO:0006814 53 53 0,000 0,30558885 0,31516523 ! tRNA metabolic process GO:0006399 53 53 0,000 0,30558885 0,31498896 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,30558885 0,31481289 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,30558885 0,31463702 ! sulfur metabolic process GO:0006790 55 54 0,000 0,31036948 0,31938077 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,31511789 0,32408609 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! protein modification by small protein conjugation or removal GO:0070647 56 55 0,000 0,31511789 0,32390534 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,31983429 0,32857001 ! ATP metabolic process GO:0046034 57 57 0,000 0,3245189 0,33319685 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,3245189 0,33301132 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,33379358 0,34233811 ! potassium ion transport GO:0006813 60 60 0,000 0,33838407 0,34685308 ! protein polymerization GO:0051258 65 60 0,000 0,33838407 0,34666028 ! cellular respiration GO:0045333 62 61 0,000 0,34294359 0,35113613 ! proteasomal protein catabolic process GO:0010498 62 61 0,000 0,34294359 0,35094117 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,34294359 0,35074642 GO:0016054|organic acid catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,34294359 0,35055188 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,34747236 0,35498423 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,34747236 0,35478757 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,34747236 0,35459112 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,35197057 0,35898271 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,35197057 0,35878416 ! regulation of cytoskeleton organization GO:0051493 66 64 0,000 0,35643843 0,36313766 ! positive regulation of protein metabolic process GO:0051247 64 64 0,000 0,35643843 0,36293703 ! anion transport GO:0006820 65 65 0,000 0,36087613 0,36725274 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,36528388 0,37153322 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,36528388 0,37132829 ! polysaccharide metabolic process GO:0005976 69 66 0,000 0,36528388 0,37112359 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,36966188 0,37536465 ! muscle contraction GO:0006936 67 67 0,000 0,36966188 0,37515795 ! Ras protein signal transduction GO:0007265 69 67 0,000 0,36966188 0,37495148 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,37401031 0,37915347 ! translational elongation GO:0006414 71 71 0,000 0,38688021 0,39198473 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,38688021 0,39176936 ! ribosome biogenesis GO:0042254 71 71 0,000 0,38688021 0,39155422 ! muscle system process GO:0003012 72 72 0,000 0,39111235 0,39562023 ! regulation of cytokine production GO:0001817 72 72 0,000 0,39111235 0,39540321 ! electron transport chain GO:0022900 75 74 0,000 0,39949103 0,40365239 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,39949103 0,40343121 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,40363794 0,4073958 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,40363794 0,40717281 ! microtubule-based movement GO:0007018 82 78 0,000 0,41591125 0,41932408 ! positive regulation of protein kinase cascade GO:0010740 79 78 0,000 0,41591125 0,41909482 ! regulation of immune response GO:0050776 78 78 0,000 0,41591125 0,41886581 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,42395574 0,42673426 ! lipid catabolic process GO:0016042 82 81 0,000 0,42793722 0,43050672 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,43581956 0,43819719 ! ncRNA processing GO:0034470 83 83 0,000 0,43581956 0,43795826 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,43972076 0,4416378 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,44744412 0,44915006 GO:0006644|phospholipid metabolic process, ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,45506326 0,45654958 ! visual perception GO:0007601 93 92 0,000 0,46999432 0,47127287 GO:0050953|sensory perception of light stimulus, ! energy derivation by oxidation of organic compounds GO:0015980 94 92 0,000 0,46999432 0,4710166 ! cofactor metabolic process GO:0051186 95 94 0,000 0,47730895 0,47808717 ! endocytosis GO:0006897 99 98 0,000 0,49164302 0,49217712 GO:0010324|membrane invagination, ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,49164302 0,49190993 ! regulation of system process GO:0044057 98 98 0,000 0,49164302 0,49164302