pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6557-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! elastic fiber assembly GO:0048251 13 9 6,000 8,204E-15 1,887E-11 ! collagen metabolic process GO:0032963 40 30 7,000 6,775E-12 7,792E-09 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 7,000 1,584E-11 1,214E-08 ! multicellular organismal metabolic process GO:0044236 50 39 7,000 6,812E-11 3,917E-08 ! aging GO:0007568 79 52 7,000 7,813E-10 3,594E-07 ! extracellular matrix organization GO:0030198 103 61 7,000 2,924E-09 1,121E-06 ! extracellular structure organization GO:0043062 156 99 8,000 7,938E-09 2,608E-06 ! release of cytochrome c from mitochondria GO:0001836 23 14 4,000 1,362E-08 3,915E-06 ! regulation of lipid kinase activity GO:0043550 12 7 3,000 4,241E-08 1,084E-05 ! regulation of DNA metabolic process GO:0051052 135 85 7,000 4,245E-08 9,763E-06 ! apoptotic mitochondrial changes GO:0008637 29 18 4,000 5,717E-08 1,195E-05 ! hormone-mediated signaling GO:0009755 49 36 5,000 6,839E-08 1,311E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 1,322E-07 2,338E-05 ! response to UV GO:0009411 75 46 5,000 3,133E-07 5,147E-05 ! gland development GO:0048732 148 77 6,000 3,924E-07 6,016E-05 ! double-strand break repair via homologous recombination GO:0000724 16 11 3,000 3,925E-07 5,643E-05 GO:0000725|recombinational repair, ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 4,000 4,225E-07 5,716E-05 ! response to protein stimulus GO:0051789 111 81 6,000 5,563E-07 7,108E-05 ! response to gamma radiation GO:0010332 20 12 3,000 5,861E-07 7,095E-05 ! interphase of mitotic cell cycle GO:0051329 156 86 6,000 8,388E-07 9,646E-05 ! interphase GO:0051325 159 88 6,000 9,813E-07 1,075E-04 ! DNA damage response, signal transduction GO:0042770 96 56 5,000 1,034E-06 1,081E-04 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 4,000 1,72E-06 1,72E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 2,087E-06 2E-04 ! nuclear migration GO:0007097 10 5 2,000 2,087E-06 1,92E-04 ! peptidyl-threonine phosphorylation GO:0018107 14 5 2,000 2,087E-06 1,846E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 2,087E-06 1,778E-04 GO:0031272|regulation of pseudopodium assembly, ! cell cycle checkpoint GO:0000075 108 64 5,000 2,298E-06 1,887E-04 ! double-strand break repair GO:0006302 67 40 4,000 3,953E-06 3,135E-04 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 2,000 4,156E-06 3,186E-04 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! macrophage differentiation GO:0030225 10 6 2,000 4,156E-06 3,083E-04 ! prostate gland development GO:0030850 9 6 2,000 4,156E-06 2,987E-04 ! ER overload response GO:0006983 7 6 2,000 4,156E-06 2,897E-04 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 5,409E-06 3,659E-04 ! response to unfolded protein GO:0006986 99 76 5,000 6,321E-06 4,154E-04 ! cell aging GO:0007569 32 21 3,000 6,797E-06 4,343E-04 ! response to endoplasmic reticulum stress GO:0034976 25 21 3,000 6,797E-06 4,225E-04 ! B cell lineage commitment GO:0002326 17 7 2,000 7,241E-06 4,383E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 7,241E-06 4,27E-04 ! T cell lineage commitment GO:0002360 12 7 2,000 7,241E-06 4,164E-04 ! peptidyl-threonine modification GO:0018210 18 7 2,000 7,241E-06 4,062E-04 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 3,000 8,27E-06 4,529E-04 ! response to estrogen stimulus GO:0043627 74 47 4,000 8,914E-06 4,768E-04 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 3,000 9,964E-06 5,209E-04 ! ER-nuclear signaling pathway GO:0006984 27 23 3,000 9,964E-06 5,093E-04 ! cell cycle arrest GO:0007050 150 86 5,000 1,295E-05 6,475E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 1,339E-05 6,554E-04 ! oocyte differentiation GO:0009994 12 9 2,000 1,723E-05 8,255E-04 GO:0048599|oocyte development, ! nucleus localization GO:0051647 15 9 2,000 1,723E-05 8,086E-04 ! response to ionizing radiation GO:0010212 47 27 3,000 1,939E-05 8,918E-04 ! regulation of lipid metabolic process GO:0019216 84 56 4,000 2,127E-05 9,591E-04 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 2,32E-05 1,026E-03 ! response to light stimulus GO:0009416 153 96 5,000 2,433E-05 1,056E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 2,45E-05 1,044E-03 ! response to X-ray GO:0010165 16 10 2,000 2,45E-05 1,025E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 2,45E-05 1,006E-03 ! protein sumoylation GO:0016925 12 10 2,000 2,45E-05 9,887E-04 ! negative regulation of kinase activity GO:0033673 100 58 4,000 2,527E-05 1,002E-03 ! regulation of homeostatic process GO:0032844 105 60 4,000 2,983E-05 1,163E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 3,234E-05 1,24E-03 ! filopodium assembly GO:0046847 19 11 2,000 3,354E-05 1,265E-03 ! T cell homeostasis GO:0043029 20 11 2,000 3,354E-05 1,244E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 3,354E-05 1,225E-03 GO:0042130|negative regulation of T cell proliferation, ! DNA damage checkpoint GO:0000077 53 31 3,000 3,412E-05 1,226E-03 ! reproductive structure development GO:0048608 90 65 4,000 4,406E-05 1,559E-03 ! microspike assembly GO:0030035 23 12 2,000 4,453E-05 1,552E-03 ! DNA integrity checkpoint GO:0031570 57 34 3,000 4,96E-05 1,703E-03 ! cellular pigmentation GO:0033059 24 13 2,000 5,764E-05 1,949E-03 ! lymphocyte homeostasis GO:0002260 24 13 2,000 5,764E-05 1,921E-03 ! response to drug GO:0042493 108 69 4,000 5,882E-05 1,933E-03 ! response to reactive oxygen species GO:0000302 55 36 3,000 6,242E-05 2,022E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 7,304E-05 2,333E-03 ! mitochondrion organization GO:0007005 104 73 4,000 7,713E-05 2,43E-03 ! response to steroid hormone stimulus GO:0048545 114 73 4,000 7,713E-05 2,397E-03 ! pigmentation GO:0043473 74 38 3,000 7,751E-05 2,377E-03 ! response to nutrient GO:0007584 104 75 4,000 8,779E-05 2,657E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 9,09E-05 2,715E-03 ! centrosome cycle GO:0007098 16 15 2,000 9,09E-05 2,68E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 9,09E-05 2,646E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 9,09E-05 2,613E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 9,09E-05 2,581E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 9,09E-05 2,55E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! JAK-STAT cascade GO:0007259 53 40 3,000 9,508E-05 2,635E-03 ! cellular response to unfolded protein GO:0034620 19 16 2,000 1,114E-04 3,05E-03 GO:0030968|endoplasmic reticulum unfolded protein response, ! oogenesis GO:0048477 23 16 2,000 1,114E-04 3,014E-03 ! G1 phase GO:0051318 27 16 2,000 1,114E-04 2,979E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 1,266E-04 3,348E-03 ! regulation of cell cycle process GO:0010564 122 81 4,000 1,267E-04 3,311E-03 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 1,347E-04 3,48E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1,347E-04 3,441E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 1,347E-04 3,404E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 1,609E-04 4,022E-03 ! reciprocal meiotic recombination GO:0007131 31 19 2,000 1,902E-04 4,704E-03 ! response to alkaloid GO:0043279 32 19 2,000 1,902E-04 4,654E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 1,902E-04 4,605E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 1,902E-04 4,557E-03 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 1,902E-04 4,51E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 1,951E-04 4,579E-03 ! reproductive developmental process GO:0003006 127 89 4,000 1,976E-04 4,59E-03 ! leukocyte differentiation GO:0002521 143 90 4,000 2,082E-04 4,789E-03 ! DNA recombination GO:0006310 146 92 4,000 2,308E-04 5,255E-03 ! response to oxidative stress GO:0006979 141 94 4,000 2,551E-04 5,753E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 2,588E-04 5,779E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 2,588E-04 5,724E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 2,588E-04 5,669E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 2,588E-04 5,616E-03 ! in utero embryonic development GO:0001701 147 96 4,000 2,814E-04 6,05E-03 ! vasculogenesis GO:0001570 33 22 2,000 2,984E-04 6,354E-03 ! microtubule organizing center organization GO:0031023 28 22 2,000 2,984E-04 6,296E-03 GO:0051297|centrosome organization, ! leukocyte homeostasis GO:0001776 33 22 2,000 2,984E-04 6,239E-03 ! blastocyst development GO:0001824 37 22 2,000 2,984E-04 6,183E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 3,416E-04 7,016E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,531E-04 7,188E-03 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 3,531E-04 7,125E-03 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 3,531E-04 7,063E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 3,531E-04 7,002E-03 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 3,531E-04 6,942E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 3,531E-04 6,883E-03 ! regulation of centrosome cycle GO:0046605 7 5 1,000 3,531E-04 6,825E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 3,531E-04 6,768E-03 ! centrosome duplication GO:0051298 5 5 1,000 3,531E-04 6,712E-03 ! response to UV-C GO:0010225 6 5 1,000 3,531E-04 6,657E-03 ! histone demethylation GO:0016577 9 5 1,000 3,531E-04 6,603E-03 ! apical protein localization GO:0045176 6 5 1,000 3,531E-04 6,55E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 3,531E-04 6,498E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 3,531E-04 6,446E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 3,531E-04 6,395E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 3,887E-04 6,985E-03 ! mitochondrial membrane organization GO:0007006 39 24 2,000 3,887E-04 6,931E-03 ! response to toxin GO:0009636 38 24 2,000 3,887E-04 6,878E-03 ! myeloid cell differentiation GO:0030099 85 59 3,000 4,339E-04 7,617E-03 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 4,398E-04 7,664E-03 ! meiosis GO:0007126 96 61 3,000 4,929E-04 8,524E-03 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 3,000 4,929E-04 8,46E-03 ! homeostasis of number of cells GO:0048872 84 61 3,000 4,929E-04 8,398E-03 ! negative regulation of cell growth GO:0030308 106 62 3,000 5,245E-04 8,87E-03 ! meiotic cell cycle GO:0051321 97 62 3,000 5,245E-04 8,805E-03 ! positive regulation of protein ubiquitination GO:0031398 8 6 1,000 5,276E-04 8,794E-03 ! positive regulation of DNA repair GO:0045739 7 6 1,000 5,276E-04 8,73E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 5,276E-04 8,668E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 5,276E-04 8,607E-03 ! male meiosis GO:0007140 7 6 1,000 5,276E-04 8,546E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 5,276E-04 8,486E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 5,276E-04 8,427E-03 ! mRNA stabilization GO:0048255 15 6 1,000 5,276E-04 8,369E-03 GO:0043489|RNA stabilization, ! protein amino acid dealkylation GO:0008214 11 6 1,000 5,276E-04 8,312E-03 GO:0006482|protein amino acid demethylation, ! protein lipoylation GO:0009249 10 6 1,000 5,276E-04 8,255E-03 ! pigment granule organization GO:0048753 11 6 1,000 5,276E-04 8,2E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 5,276E-04 8,145E-03 ! neuron apoptosis GO:0051402 8 6 1,000 5,276E-04 8,09E-03 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 5,276E-04 8,037E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 5,276E-04 7,984E-03 ! G2 phase GO:0051319 13 6 1,000 5,276E-04 7,932E-03 GO:0000085|G2 phase of mitotic cell cycle, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 5,276E-04 7,88E-03 ! blastocyst growth GO:0001832 15 6 1,000 5,276E-04 7,829E-03 ! negative regulation of B cell activation GO:0050869 9 6 1,000 5,276E-04 7,779E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 5,276E-04 7,73E-03 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 5,545E-04 8,072E-03 ! negative regulation of protein transport GO:0051224 49 27 2,000 5,545E-04 8,021E-03 ! negative regulation of cell size GO:0045792 108 64 3,000 5,919E-04 8,509E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 6,183E-04 8,833E-03 ! response to organic cyclic substance GO:0014070 47 28 2,000 6,183E-04 8,779E-03 ! response to hydrogen peroxide GO:0042542 42 29 2,000 6,867E-04 9,689E-03 ! tissue homeostasis GO:0001894 42 29 2,000 6,867E-04 9,63E-03 GO:0048871|multicellular organismal homeostasis, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 7,358E-04 0,01025626 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 7,358E-04 0,01019448 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 7,358E-04 0,01013343 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 7,358E-04 0,01007312 ! T-helper 1 type immune response GO:0042088 11 7 1,000 7,358E-04 0,01001351 ! protein-cofactor linkage GO:0018065 13 7 1,000 7,358E-04 9,955E-03 ! regulation of pigmentation during development GO:0048070 15 7 1,000 7,358E-04 9,896E-03 ! asymmetric protein localization GO:0008105 8 7 1,000 7,358E-04 9,839E-03 ! organ growth GO:0035265 11 7 1,000 7,358E-04 9,782E-03 ! behavioral fear response GO:0001662 13 7 1,000 7,358E-04 9,726E-03 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 7,358E-04 9,67E-03 ! response to UV-B GO:0010224 11 7 1,000 7,358E-04 9,615E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 7,358E-04 9,561E-03 ! response to tumor cell GO:0002347 12 7 1,000 7,358E-04 9,507E-03 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 7,358E-04 9,454E-03 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 7,358E-04 9,402E-03 ! negative regulation of cell activation GO:0050866 44 30 2,000 7,597E-04 9,653E-03 ! mammary gland development GO:0030879 57 31 2,000 8,374E-04 0,01058253 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 9,2E-04 0,011563 ! meiosis I GO:0007127 52 32 2,000 9,2E-04 0,01150015 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 9,772E-04 0,01214883 ! induction of positive chemotaxis GO:0050930 14 8 1,000 9,772E-04 0,01208352 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 9,772E-04 0,0120189 ! middle ear morphogenesis GO:0042474 9 8 1,000 9,772E-04 0,01195497 ! melanin metabolic process GO:0006582 12 8 1,000 9,772E-04 0,01189172 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 9,772E-04 0,01182913 ! multicellular organism growth GO:0035264 14 8 1,000 9,772E-04 0,01176719 ! regulation of vascular permeability GO:0043114 12 8 1,000 9,772E-04 0,01170591 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 9,772E-04 0,01164525 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 9,772E-04 0,01158523 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 9,772E-04 0,01152582 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 9,772E-04 0,01146701 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 1,000 9,772E-04 0,0114088 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 9,772E-04 0,01135118 ! regulation of telomere maintenance GO:0032204 10 8 1,000 9,772E-04 0,01129414 ! regulation of embryonic development GO:0045995 16 8 1,000 9,772E-04 0,01123767 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 9,772E-04 0,01118176 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 1,008E-03 0,01147286 ! nucleus organization GO:0006997 49 33 2,000 1,008E-03 0,01141635 ! female gonad development GO:0008585 49 33 2,000 1,008E-03 0,01136038 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,008E-03 0,01130497 ! negative regulation of growth GO:0045926 123 75 3,000 1,077E-03 0,01202049 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 1,1E-03 0,01222586 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 1,1E-03 0,01216709 ! female gamete generation GO:0007292 43 34 2,000 1,1E-03 0,01210887 ! sex differentiation GO:0007548 105 77 3,000 1,188E-03 0,01300885 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,198E-03 0,01306157 ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 1,251E-03 0,0135772 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 1,251E-03 0,01351346 ! lung alveolus development GO:0048286 17 9 1,000 1,251E-03 0,01345031 ! T cell selection GO:0045058 18 9 1,000 1,251E-03 0,01338775 ! epithelial cell development GO:0002064 10 9 1,000 1,251E-03 0,01332577 ! motor axon guidance GO:0008045 14 9 1,000 1,251E-03 0,01326436 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,251E-03 0,01320351 ! response to amine stimulus GO:0014075 13 9 1,000 1,251E-03 0,01314322 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! postreplication repair GO:0006301 11 9 1,000 1,251E-03 0,01308348 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,251E-03 0,01302428 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 1,251E-03 0,01296561 ! thymus development GO:0048538 15 9 1,000 1,251E-03 0,01290747 ! spleen development GO:0048536 15 9 1,000 1,251E-03 0,01284985 ! blastocyst formation GO:0001825 12 9 1,000 1,251E-03 0,01279274 ! embryonic placenta development GO:0001892 12 9 1,000 1,251E-03 0,01273613 ! response to nicotine GO:0035094 16 9 1,000 1,251E-03 0,01268003 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 1,302E-03 0,01312932 GO:0046660|female sex differentiation, ! regulation of T cell proliferation GO:0042129 58 38 2,000 1,524E-03 0,01531096 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,558E-03 0,01558204 ! hair follicle morphogenesis GO:0031069 17 10 1,000 1,558E-03 0,01551458 ! blood vessel remodeling GO:0001974 21 10 1,000 1,558E-03 0,01544771 ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 1,558E-03 0,01538141 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,558E-03 0,01531568 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 1,558E-03 0,0152505 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,558E-03 0,01518588 ! B cell proliferation GO:0042100 14 10 1,000 1,558E-03 0,01512181 ! fear response GO:0042596 16 10 1,000 1,558E-03 0,01505827 ! negative regulation of ossification GO:0030279 19 10 1,000 1,558E-03 0,01499527 ! regulation of bone resorption GO:0045124 24 10 1,000 1,558E-03 0,01493278 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,558E-03 0,01487082 ! DNA methylation GO:0006306 15 10 1,000 1,558E-03 0,01480937 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 1,000 1,558E-03 0,01474843 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,558E-03 0,01468799 ! regulation of cell adhesion GO:0030155 159 83 3,000 1,569E-03 0,01473089 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,644E-03 0,01537365 ! developmental growth GO:0048589 62 39 2,000 1,644E-03 0,0153114 ! regulation of protein localization GO:0032880 132 85 3,000 1,713E-03 0,01588882 ! T cell differentiation GO:0030217 65 40 2,000 1,77E-03 0,01634871 ! B cell differentiation GO:0030183 62 40 2,000 1,77E-03 0,01628331 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 1,77E-03 0,01621844 ! RNA polyadenylation GO:0043631 19 11 1,000 1,897E-03 0,01731404 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 1,897E-03 0,01724561 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,897E-03 0,01717771 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 1,897E-03 0,01711035 ! regulation of mRNA processing GO:0050684 18 11 1,000 1,897E-03 0,01704351 ! focal adhesion formation GO:0048041 24 11 1,000 1,897E-03 0,01697719 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,897E-03 0,01691139 ! nitric oxide metabolic process GO:0046209 14 11 1,000 1,897E-03 0,0168461 GO:0006809|nitric oxide biosynthetic process, ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,897E-03 0,0167813 ! digestive tract morphogenesis GO:0048546 15 11 1,000 1,897E-03 0,01671701 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! mRNA 3'-end processing GO:0031124 19 11 1,000 1,897E-03 0,0166532 ! actin filament polymerization GO:0030041 17 11 1,000 1,897E-03 0,01658988 ! mitochondrial transport GO:0006839 60 42 2,000 2,039E-03 0,01776193 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 2,039E-03 0,01769491 ! cellular component disassembly GO:0022411 64 42 2,000 2,039E-03 0,01762838 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 2,039E-03 0,01756236 ! regulation of gene expression, epigenetic GO:0040029 72 42 2,000 2,039E-03 0,01749683 ! regulation of cell shape GO:0008360 78 42 2,000 2,039E-03 0,01743178 ! protein modification by small protein conjugation GO:0032446 140 90 3,000 2,113E-03 0,01800082 ! activation of caspase activity GO:0006919 65 43 2,000 2,182E-03 0,01852027 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 2,182E-03 0,01845218 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 2,268E-03 0,0191036 ! gland morphogenesis GO:0022612 23 12 1,000 2,268E-03 0,01903388 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,268E-03 0,01896466 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,268E-03 0,01889595 ! RNA 3'-end processing GO:0031123 20 12 1,000 2,268E-03 0,01882773 ! cell fate commitment GO:0045165 141 92 3,000 2,29E-03 0,01894385 ! regulation of cell projection organization GO:0031344 83 44 2,000 2,332E-03 0,01922187 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,332E-03 0,01915322 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 2,382E-03 0,01949463 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,487E-03 0,02028752 ! cell maturation GO:0048469 60 45 2,000 2,487E-03 0,02021583 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,669E-03 0,02161765 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 2,669E-03 0,0215418 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 2,669E-03 0,02146648 ! bone mineralization GO:0030282 15 13 1,000 2,669E-03 0,02139168 ! regulation of DNA repair GO:0006282 15 13 1,000 2,669E-03 0,02131741 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 2,669E-03 0,02124364 ! regulation of cellular pH GO:0030641 20 13 1,000 2,669E-03 0,02117039 ! regulation of RNA stability GO:0043487 28 13 1,000 2,669E-03 0,02109764 ! protein modification by small protein conjugation or removal GO:0070647 148 96 3,000 2,673E-03 0,02105415 ! negative regulation of immune system process GO:0002683 73 47 2,000 2,818E-03 0,02211956 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 2,818E-03 0,02204432 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 2,818E-03 0,02196959 ! positive regulation of caspase activity GO:0043280 72 48 2,000 2,993E-03 0,02325399 GO:0010952|positive regulation of peptidase activity, ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 3,102E-03 0,0240224 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 3,102E-03 0,02394178 ! regulation of S phase GO:0033261 18 14 1,000 3,102E-03 0,02386171 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 3,102E-03 0,02378217 ! epidermis morphogenesis GO:0048730 29 14 1,000 3,102E-03 0,02370316 ! pituitary gland development GO:0021983 23 14 1,000 3,102E-03 0,02362467 ! cellular response to starvation GO:0009267 21 14 1,000 3,102E-03 0,0235467 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 3,102E-03 0,02346925 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 3,102E-03 0,0233923 ! G1/S transition checkpoint GO:0031575 33 14 1,000 3,102E-03 0,02331585 ! DNA unwinding during replication GO:0006268 21 14 1,000 3,102E-03 0,02323991 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 3,102E-03 0,02316445 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 3,102E-03 0,02308949 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 3,102E-03 0,023015 ! regulation of intracellular transport GO:0032386 78 49 2,000 3,174E-03 0,02347384 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 3,174E-03 0,0233986 ! germ cell development GO:0007281 68 49 2,000 3,174E-03 0,02332384 ! ear development GO:0043583 72 50 2,000 3,362E-03 0,0246266 ! positive regulation of cell migration GO:0030335 92 51 2,000 3,557E-03 0,02596991 ! metencephalon development GO:0022037 19 15 1,000 3,565E-03 0,02594977 ! regulation of survival gene product expression GO:0045884 20 15 1,000 3,565E-03 0,02586791 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 3,565E-03 0,02578656 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 3,565E-03 0,02570573 ! biomineral formation GO:0031214 18 15 1,000 3,565E-03 0,0256254 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 3,565E-03 0,02554557 ! defense response to virus GO:0051607 27 15 1,000 3,565E-03 0,02546623 ! nucleotide-excision repair GO:0006289 64 52 2,000 3,758E-03 0,02676112 ! establishment of organelle localization GO:0051656 85 52 2,000 3,758E-03 0,02667852 ! regulation of bone remodeling GO:0046850 90 53 2,000 3,966E-03 0,02807038 ! cell projection assembly GO:0030031 76 53 2,000 3,966E-03 0,02798427 ! endothelial cell migration GO:0043542 22 16 1,000 4,059E-03 0,02854733 ! regulation of protein binding GO:0043393 27 16 1,000 4,059E-03 0,02846029 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 4,059E-03 0,02837379 ! diencephalon development GO:0021536 25 16 1,000 4,059E-03 0,02828781 ! regulation of protein complex assembly GO:0043254 81 54 2,000 4,182E-03 0,02905673 ! DNA catabolic process GO:0006308 67 54 2,000 4,182E-03 0,02896921 ! regulation of tissue remodeling GO:0034103 91 54 2,000 4,182E-03 0,02888221 ! regulation of viral genome replication GO:0045069 24 17 1,000 4,582E-03 0,03155193 ! DNA duplex unwinding GO:0032508 25 17 1,000 4,582E-03 0,03145774 GO:0032392|DNA geometric change, ! cell-substrate junction assembly GO:0007044 39 17 1,000 4,582E-03 0,03136412 ! actin polymerization or depolymerization GO:0008154 31 17 1,000 4,582E-03 0,03127105 ! neuromuscular junction development GO:0007528 23 17 1,000 4,582E-03 0,03117853 ! positive regulation of cell motion GO:0051272 99 56 2,000 4,633E-03 0,03143308 ! multicellular organism reproduction GO:0032504 83 57 2,000 4,869E-03 0,03293896 GO:0048609|reproductive process in a multicellular organism, ! developmental maturation GO:0021700 75 57 2,000 4,869E-03 0,03284236 ! gonad development GO:0008406 79 57 2,000 4,869E-03 0,03274633 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 5,113E-03 0,03428321 ! cellular response to nutrient levels GO:0031669 27 18 1,000 5,135E-03 0,0343296 ! gut development GO:0048565 26 18 1,000 5,135E-03 0,03423009 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 5,135E-03 0,03413116 ! lung development GO:0030324 94 59 2,000 5,363E-03 0,03554939 ! actin filament organization GO:0007015 95 59 2,000 5,363E-03 0,03544724 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 5,716E-03 0,0376712 ! regeneration GO:0031099 32 19 1,000 5,716E-03 0,03756356 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 5,716E-03 0,03745655 ! sensory perception of taste GO:0050909 23 19 1,000 5,716E-03 0,03735014 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 5,716E-03 0,03724433 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 5,716E-03 0,03713912 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 5,716E-03 0,0370345 ! response to starvation GO:0042594 30 19 1,000 5,716E-03 0,03693047 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 5,716E-03 0,03682702 ! renal system process GO:0003014 35 19 1,000 5,716E-03 0,03672416 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 5,716E-03 0,03662186 ! regulation of cellular response to stress GO:0080135 85 61 2,000 5,887E-03 0,03760823 ! respiratory tube development GO:0030323 99 62 2,000 6,159E-03 0,03924113 ! organelle localization GO:0051640 96 62 2,000 6,159E-03 0,03913273 ! response to ethanol GO:0045471 37 20 1,000 6,327E-03 0,04008571 ! multicellular organismal response to stress GO:0033555 32 20 1,000 6,327E-03 0,03997558 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 6,327E-03 0,03986606 ! DNA modification GO:0006304 28 20 1,000 6,327E-03 0,03975713 ! positive regulation of locomotion GO:0040017 35 20 1,000 6,327E-03 0,0396488 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen catabolic process GO:0030574 25 20 1,000 6,327E-03 0,03954106 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 6,439E-03 0,04013615 ! respiratory system development GO:0060541 100 64 2,000 6,727E-03 0,04181528 ! protein amino acid acylation GO:0043543 37 21 1,000 6,965E-03 0,04318098 ! regulation of chemotaxis GO:0050920 36 21 1,000 6,965E-03 0,04306491 ! regulation of DNA recombination GO:0000018 40 21 1,000 6,965E-03 0,04294945 ! ovarian follicle development GO:0001541 30 21 1,000 6,965E-03 0,04283461 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 6,965E-03 0,04272039 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 6,965E-03 0,04260677 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 6,965E-03 0,04249375 ! response to cytokine stimulus GO:0034097 47 21 1,000 6,965E-03 0,04238134 ! regulation of caspase activity GO:0043281 97 65 2,000 7,022E-03 0,04261321 ! B cell activation GO:0042113 104 65 2,000 7,022E-03 0,04250107 ! protein oligomerization GO:0051259 100 65 2,000 7,022E-03 0,04238952 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 7,632E-03 0,04595166 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 7,632E-03 0,04583168 ! molting cycle process GO:0022404 40 22 1,000 7,632E-03 0,04571232 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 7,632E-03 0,04559359 GO:0010810|regulation of cell-substrate adhesion, ! ureteric bud development GO:0001657 32 22 1,000 7,632E-03 0,04547547 ! regulation of behavior GO:0050795 38 22 1,000 7,632E-03 0,04535797 ! protein tetramerization GO:0051262 39 22 1,000 7,632E-03 0,04524106 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 7,635E-03 0,04514232 ! development of primary sexual characteristics GO:0045137 92 68 2,000 7,953E-03 0,04690196 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 8,326E-03 0,04897816 ! myelination GO:0042552 35 23 1,000 8,326E-03 0,04885322 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 8,326E-03 0,04872891 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 8,326E-03 0,04860523 ! regulation of viral reproduction GO:0050792 32 23 1,000 8,326E-03 0,04848218 ! lymphocyte proliferation GO:0046651 36 23 1,000 8,326E-03 0,04835975 ! cellular response to oxidative stress GO:0034599 33 23 1,000 8,326E-03 0,04823794 ! response to metal ion GO:0010038 103 70 2,000 8,612E-03 0,04976864 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 8,953E-03 0,05161115 ! lymphocyte differentiation GO:0030098 113 71 2,000 8,953E-03 0,05148213 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 9,048E-03 0,05189558 ! fat cell differentiation GO:0045444 37 24 1,000 9,048E-03 0,05176649 ! negative regulation of cell development GO:0010721 56 24 1,000 9,048E-03 0,05163804 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 9,048E-03 0,05151022 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 9,048E-03 0,05138304 ! regulation of peptidase activity GO:0052547 106 72 2,000 9,303E-03 0,05269902 ! response to hypoxia GO:0001666 132 72 2,000 9,303E-03 0,05256954 ! tube morphogenesis GO:0035239 118 73 2,000 9,66E-03 0,05445308 ! negative regulation of transport GO:0051051 116 73 2,000 9,66E-03 0,05431994 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 9,796E-03 0,05495546 ! male gonad development GO:0008584 33 25 1,000 9,796E-03 0,05482175 ! iron ion homeostasis GO:0055072 39 25 1,000 9,796E-03 0,05468869 ! regulation of chromosome organization GO:0033044 35 25 1,000 9,796E-03 0,05455627 ! response to estradiol stimulus GO:0032355 34 25 1,000 9,796E-03 0,05442449 ! leukocyte proliferation GO:0070661 39 25 1,000 9,796E-03 0,05429335 GO:0032943|mononuclear cell proliferation, ! response to oxygen levels GO:0070482 137 74 2,000 0,01002439 0,0554233 ! protein import into nucleus GO:0006606 118 74 2,000 0,01002439 0,05529039 ! response to inorganic substance GO:0010035 115 75 2,000 0,01039721 0,05720954 ! nuclear import GO:0051170 121 75 2,000 0,01039721 0,057073 ! regulation of pH GO:0006885 36 26 1,000 0,01057152 0,05789167 ! post-embryonic development GO:0009791 42 26 1,000 0,01057152 0,05775416 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 0,01057152 0,0576173 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01057152 0,05748109 ! regulation of cell morphogenesis GO:0022604 140 76 2,000 0,01077801 0,0584656 ! regulation of protein transport GO:0051223 114 76 2,000 0,01077801 0,05832803 GO:0070201|regulation of establishment of protein localization, ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01137288 0,06140289 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01137288 0,06125909 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,01156362 0,06214095 ! T cell activation GO:0042110 134 79 2,000 0,0119685 0,06416678 ! cell junction assembly GO:0034329 56 28 1,000 0,01220016 0,06525665 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01220016 0,06510524 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01220016 0,06495454 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,01220016 0,06480453 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01220016 0,06465521 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01220016 0,06450658 ! placenta development GO:0001890 37 28 1,000 0,01220016 0,06435863 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01220016 0,06421135 ! protein localization in nucleus GO:0034504 133 80 2,000 0,01238146 0,06501679 ! forebrain development GO:0030900 131 80 2,000 0,01238146 0,06486869 ! ovulation cycle process GO:0022602 41 29 1,000 0,01305301 0,06823163 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01305301 0,06807691 ! ovulation cycle GO:0042698 43 30 1,000 0,0139311 0,07249216 ! hindbrain development GO:0030902 45 30 1,000 0,0139311 0,07232852 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,0139311 0,07216562 ! response to heat GO:0009408 41 30 1,000 0,0139311 0,07200345 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01411458 0,07278821 ! regulation of membrane potential GO:0042391 128 85 2,000 0,01456829 0,07495989 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,01456829 0,07479256 ! xenobiotic metabolic process GO:0006805 44 31 1,000 0,01483412 0,07598768 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,01483412 0,07581882 ! metanephros development GO:0001656 58 31 1,000 0,01483412 0,07565071 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01483412 0,07548334 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01483412 0,07531671 ! female pregnancy GO:0007565 130 87 2,000 0,01550035 0,078526 ! regulation of muscle development GO:0048634 48 32 1,000 0,01576172 0,07967465 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01576172 0,07949992 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01576172 0,07932596 ! regulation of protein stability GO:0031647 48 32 1,000 0,01576172 0,07915276 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,01597873 0,08006772 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,01646537 0,08232684 ! regulation of T cell activation GO:0050863 128 89 2,000 0,01646537 0,08214826 ! ear morphogenesis GO:0042471 42 33 1,000 0,0167136 0,08320624 ! cell junction organization GO:0034330 63 33 1,000 0,0167136 0,08302653 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,0167136 0,08284759 GO:0042593|glucose homeostasis, ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,0167136 0,08266943 ! positive regulation of cell development GO:0010720 54 33 1,000 0,0167136 0,08249202 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,0167136 0,08231538 ! cytokinesis GO:0000910 52 33 1,000 0,0167136 0,08213949 ! response to virus GO:0009615 122 91 2,000 0,01746346 0,08564168 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01768943 0,0865653 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01768943 0,08638151 ! embryonic organ development GO:0048568 45 34 1,000 0,01768943 0,0861985 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,0186889 0,09087624 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,0186889 0,09068452 ! pigment metabolic process GO:0042440 61 35 1,000 0,0186889 0,0904936 ! protein homooligomerization GO:0051260 52 35 1,000 0,0186889 0,09030349 ! regulation of binding GO:0051098 151 95 2,000 0,01955918 0,09431051 ! negative regulation of binding GO:0051100 58 36 1,000 0,01971168 0,09484701 ! tissue remodeling GO:0048771 62 36 1,000 0,01971168 0,094649 ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,01971168 0,09445182 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,0201039 0,0961309 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 0,02065694 0,09857046 ! learning GO:0007612 67 37 1,000 0,02075748 0,09884515 ! protein import GO:0017038 156 99 2,000 0,02178802 0,1035381 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02182598 0,10350467 ! mesenchymal cell development GO:0014031 64 38 1,000 0,02182598 0,10329169 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! protein localization in organelle GO:0033365 161 100 2,000 0,02236606 0,10563025 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,02291689 0,10800991 ! male sex differentiation GO:0046661 53 39 1,000 0,02291689 0,10778903 ! cell growth GO:0016049 61 39 1,000 0,02291689 0,10756905 ! synapse organization GO:0050808 55 39 1,000 0,02291689 0,10734997 ! response to calcium ion GO:0051592 58 40 1,000 0,02402988 0,11233482 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,02402988 0,11210696 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02402988 0,11188002 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,02402988 0,111654 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,02516468 0,11669105 ! protein amino acid lipidation GO:0006497 62 41 1,000 0,02516468 0,11645626 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,02516468 0,11622241 ! biopolymer methylation GO:0043414 62 41 1,000 0,02516468 0,1159895 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,02516468 0,11575752 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,02632097 0,12083481 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,02749848 0,12598904 ! vesicle organization GO:0016050 79 43 1,000 0,02749848 0,12573856 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,02749848 0,12548908 ! methylation GO:0032259 64 43 1,000 0,02749848 0,12524059 ! regulation of action potential GO:0001508 71 44 1,000 0,0286969 0,13044043 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,0286969 0,13018315 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,0286969 0,12992689 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,0286969 0,12967163 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02967566 0,13383142 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02967566 0,13356951 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02967566 0,13330864 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02967566 0,13304878 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02967566 0,13278993 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02967566 0,13253208 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02967566 0,13227524 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02967566 0,13201939 ! sleep GO:0030431 11 5 0,000 0,02967566 0,13176452 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02967566 0,13151064 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02967566 0,13125773 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02967566 0,1310058 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02967566 0,13075483 ! tongue development GO:0043586 6 5 0,000 0,02967566 0,13050482 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02967566 0,13025577 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02967566 0,13000766 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02967566 0,1297605 ! cobalt ion transport GO:0006824 9 5 0,000 0,02967566 0,12951427 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02967566 0,12926898 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02967566 0,12902462 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02967566 0,12878117 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02967566 0,12853865 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02967566 0,12829703 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02967566 0,12805633 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02967566 0,12781652 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02967566 0,12757761 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02967566 0,12733959 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02967566 0,12710246 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02967566 0,12686621 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02967566 0,12663084 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02967566 0,12639634 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02967566 0,1261627 ! malate metabolic process GO:0006108 7 5 0,000 0,02967566 0,12592993 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02967566 0,12569801 ! behavioral response to pain GO:0048266 7 5 0,000 0,02967566 0,12546695 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02967566 0,12523674 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02967566 0,12500737 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02967566 0,12477883 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02967566 0,12455114 ! mating behavior GO:0007617 6 5 0,000 0,02967566 0,12432427 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02967566 0,12409822 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02967566 0,123873 ! rhythmic behavior GO:0007622 12 5 0,000 0,02967566 0,12364859 ! copulation GO:0007620 7 5 0,000 0,02967566 0,12342499 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02967566 0,12320221 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02967566 0,12298022 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02967566 0,12275903 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02967566 0,12253864 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02967566 0,12231904 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02967566 0,12210022 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02967566 0,12188218 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02967566 0,12166492 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02967566 0,12144844 ! response to protozoan GO:0001562 9 5 0,000 0,02967566 0,12123272 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,02967566 0,12101777 ! lymph vessel development GO:0001945 7 5 0,000 0,02967566 0,12080358 ! endochondral ossification GO:0001958 12 5 0,000 0,02967566 0,12059015 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02967566 0,12037746 ! parathyroid gland development GO:0060017 8 5 0,000 0,02967566 0,12016553 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02967566 0,11995434 ! anagen GO:0042640 6 5 0,000 0,02967566 0,1197439 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02967566 0,11953419 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02967566 0,11932521 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02967566 0,11911697 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02967566 0,11890945 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02967566 0,11870265 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02967566 0,11849657 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02967566 0,1182912 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02967566 0,11808654 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02967566 0,11788259 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02967566 0,11767935 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02967566 0,1174768 ! ovulation GO:0030728 6 5 0,000 0,02967566 0,11727495 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02967566 0,11707379 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02967566 0,11687333 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02967566 0,11667354 ! response to pH GO:0009268 9 5 0,000 0,02967566 0,11647444 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02967566 0,11627602 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02967566 0,11607827 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02967566 0,11588119 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02967566 0,11568478 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02967566 0,11548904 ! polyol catabolic process GO:0046174 7 5 0,000 0,02967566 0,11529396 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02967566 0,11509953 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02967566 0,11490576 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02967566 0,11471264 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02967566 0,11452017 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02967566 0,11432835 ! urea metabolic process GO:0019627 6 5 0,000 0,02967566 0,11413716 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02967566 0,11394661 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02967566 0,1137567 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02967566 0,11356742 ! neutrophil activation GO:0042119 5 5 0,000 0,02967566 0,11337877 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02967566 0,11319075 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02967566 0,11300335 ! response to food GO:0032094 5 5 0,000 0,02967566 0,11281657 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02967566 0,1126304 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02967566 0,11244485 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02967566 0,1122599 ! forebrain neuron development GO:0021884 7 5 0,000 0,02967566 0,11207557 ! melanosome organization GO:0032438 7 5 0,000 0,02967566 0,11189184 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02967566 0,11170871 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02967566 0,11152618 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02967566 0,11134424 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02967566 0,1111629 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02967566 0,11098215 ! nucleoside transport GO:0015858 6 5 0,000 0,02967566 0,11080198 ! nucleoside salvage GO:0043174 7 5 0,000 0,02967566 0,1106224 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02967566 0,1104434 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02967566 0,11026498 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02967566 0,11008713 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02967566 0,10990986 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02967566 0,10973315 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02967566 0,10955702 ! depyrimidination GO:0045008 8 5 0,000 0,02967566 0,10938145 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02967566 0,10920644 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02967566 0,10903198 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02967566 0,10885809 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02967566 0,10868475 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02967566 0,10851196 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02967566 0,10833972 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02967566 0,10816802 ! monocyte differentiation GO:0030224 8 5 0,000 0,02967566 0,10799687 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02967566 0,10782626 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02967566 0,10765619 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02967566 0,10748665 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02967566 0,10731764 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02967566 0,10714917 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02967566 0,10698123 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02967566 0,10681381 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02967566 0,10664691 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02967566 0,10648053 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02967566 0,10631468 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02967566 0,10614933 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02967566 0,10598451 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02967566 0,10582019 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02967566 0,10565638 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02967566 0,10549308 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02967566 0,10533028 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02967566 0,10516798 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02967566 0,10500619 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02967566 0,10484489 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02967566 0,10468408 ! neural tube patterning GO:0021532 6 5 0,000 0,02967566 0,10452377 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02967566 0,10436395 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02967566 0,10420461 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02967566 0,10404577 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02967566 0,1038874 ! enteric nervous system development GO:0048484 8 5 0,000 0,02967566 0,10372952 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02967566 0,10357211 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02967566 0,10341519 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02967566 0,10325873 ! transcription termination GO:0006353 8 5 0,000 0,02967566 0,10310275 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02967566 0,10294724 ! plasminogen activation GO:0031639 5 5 0,000 0,02967566 0,1027922 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,02967566 0,10263763 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02967566 0,10248352 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02967566 0,10232987 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02967566 0,10217668 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02967566 0,10202395 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02967566 0,10187167 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02967566 0,10171985 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02967566 0,10156849 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02967566 0,10141757 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02967566 0,1012671 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02967566 0,10111707 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02967566 0,10096749 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02967566 0,10081835 ! glial cell migration GO:0008347 10 5 0,000 0,02967566 0,10066965 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02967566 0,10052139 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02967566 0,10037356 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02967566 0,10022617 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02967566 0,10007921 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02967566 0,09993268 ! neural plate development GO:0001840 6 5 0,000 0,02967566 0,09978658 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02967566 0,09964091 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02967566 0,09949566 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02967566 0,09935083 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02967566 0,09920643 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02967566 0,09906244 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02967566 0,09891887 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02967566 0,09877572 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02967566 0,09863298 ! spindle assembly GO:0051225 5 5 0,000 0,02967566 0,09849065 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02967566 0,09834874 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02967566 0,09820723 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02967566 0,09806612 ! organ regeneration GO:0031100 7 5 0,000 0,02967566 0,09792543 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02967566 0,09778513 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02967566 0,09764524 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02967566 0,09750575 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02967566 0,09736665 GO:0055081|anion homeostasis, ! lipoprotein biosynthetic process GO:0042158 67 45 1,000 0,02991594 0,09801519 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,02991594 0,09787576 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,02991594 0,09773674 ! cell redox homeostasis GO:0045454 63 46 1,000 0,03115533 0,10164149 ! regulation of ossification GO:0030278 71 46 1,000 0,03115533 0,10149752 ! histone modification GO:0016570 68 46 1,000 0,03115533 0,10135396 ! endocrine system development GO:0035270 83 47 1,000 0,03241477 0,10530222 ! covalent chromatin modification GO:0016569 75 47 1,000 0,03241477 0,1051537 ! response to temperature stimulus GO:0009266 62 48 1,000 0,03369399 0,10914955 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,03369399 0,10899603 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,03499271 0,11303825 ! tRNA transcription GO:0009304 11 6 0,000 0,03550527 0,11453313 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03550527 0,11437272 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03550527 0,11421276 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03550527 0,11405324 GO:0030816|positive regulation of cAMP metabolic process, ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03550527 0,11389417 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03550527 0,11373554 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03550527 0,11357736 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03550527 0,11341961 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03550527 0,1132623 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03550527 0,11310543 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03550527 0,11294899 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03550527 0,11279298 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03550527 0,11263741 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03550527 0,11248226 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03550527 0,11232754 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,03550527 0,11217324 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,03550527 0,11201937 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03550527 0,11186592 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03550527 0,11171289 ! signal peptide processing GO:0006465 8 6 0,000 0,03550527 0,11156027 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03550527 0,11140808 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03550527 0,11125629 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03550527 0,11110493 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03550527 0,11095397 ! opsonization GO:0008228 8 6 0,000 0,03550527 0,11080342 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03550527 0,11065328 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03550527 0,11050355 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03550527 0,11035422 ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03550527 0,11020529 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03550527 0,11005677 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03550527 0,10990864 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03550527 0,10976091 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03550527 0,10961358 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03550527 0,10946665 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03550527 0,10932011 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03550527 0,10917396 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03550527 0,1090282 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03550527 0,10888283 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03550527 0,10873784 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03550527 0,10859324 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03550527 0,10844903 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03550527 0,1083052 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03550527 0,10816175 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03550527 0,10801868 ! thymic T cell selection GO:0045061 12 6 0,000 0,03550527 0,10787598 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03550527 0,10773367 ! drug transport GO:0015893 6 6 0,000 0,03550527 0,10759173 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03550527 0,10745016 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03550527 0,10730896 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03550527 0,10716814 ! histidine metabolic process GO:0006547 6 6 0,000 0,03550527 0,10702768 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03550527 0,10688759 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03550527 0,10674787 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03550527 0,10660851 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03550527 0,10646952 ! adenohypophysis development GO:0021984 10 6 0,000 0,03550527 0,10633089 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03550527 0,10619261 ! hyperosmotic response GO:0006972 8 6 0,000 0,03550527 0,1060547 ! microtubule nucleation GO:0007020 10 6 0,000 0,03550527 0,10591715 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03550527 0,10577995 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03550527 0,1056431 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03550527 0,10550662 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03550527 0,10537048 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03550527 0,10523469 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03550527 0,10509925 ! response to dietary excess GO:0002021 7 6 0,000 0,03550527 0,10496416 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03550527 0,10482942 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03550527 0,10469503 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03550527 0,10456097 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03550527 0,10442726 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03550527 0,1042939 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03550527 0,10416087 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03550527 0,10402818 ! organic alcohol transport GO:0015850 9 6 0,000 0,03550527 0,10389583 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03550527 0,10376381 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03550527 0,10363213 ! male sex determination GO:0030238 9 6 0,000 0,03550527 0,10350079 ! carnitine transport GO:0015879 8 6 0,000 0,03550527 0,10336977 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03550527 0,10323909 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03550527 0,10310874 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03550527 0,10297871 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03550527 0,10284902 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03550527 0,10271965 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03550527 0,1025906 ! parturition GO:0007567 12 6 0,000 0,03550527 0,10246188 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03550527 0,10233348 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03550527 0,10220541 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03550527 0,10207765 ! spindle checkpoint GO:0031577 14 6 0,000 0,03550527 0,10195021 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03550527 0,10182309 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03550527 0,10169629 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03550527 0,1015698 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03550527 0,10144363 ! astrocyte development GO:0014002 14 6 0,000 0,03550527 0,10131777 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03550527 0,10119222 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03550527 0,10106698 ! interaction with symbiont GO:0051702 8 6 0,000 0,03550527 0,10094205 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03550527 0,10081743 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03550527 0,10069312 ! eating behavior GO:0042755 6 6 0,000 0,03550527 0,10056911 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03550527 0,10044541 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03550527 0,10032201 ! response to copper ion GO:0046688 9 6 0,000 0,03550527 0,10019892 ! DNA topological change GO:0006265 8 6 0,000 0,03550527 0,10007613 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03550527 0,09995364 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03550527 0,09983144 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03550527 0,09970955 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03550527 0,09958795 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03550527 0,09946665 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03550527 0,09934564 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03550527 0,09922493 ! gas homeostasis GO:0033483 11 6 0,000 0,03550527 0,09910451 ! hair follicle maturation GO:0048820 7 6 0,000 0,03550527 0,09898439 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03550527 0,09886455 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03550527 0,09874501 ! Schwann cell development GO:0014044 14 6 0,000 0,03550527 0,09862575 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03550527 0,09850678 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03550527 0,0983881 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03550527 0,0982697 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03550527 0,09815159 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03550527 0,09803376 ! histone ubiquitination GO:0016574 7 6 0,000 0,03550527 0,09791621 ! regulation of meiosis GO:0040020 10 6 0,000 0,03550527 0,09779895 GO:0051445|regulation of meiotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03550527 0,09768196 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03550527 0,09756526 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03550527 0,09744883 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03550527 0,09733268 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03550527 0,09721681 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03550527 0,09710121 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03550527 0,09698589 ! receptor internalization GO:0031623 9 6 0,000 0,03550527 0,09687084 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03550527 0,09675607 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03550527 0,09664156 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03550527 0,09652733 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03550527 0,09641336 ! protein deubiquitination GO:0016579 8 6 0,000 0,03550527 0,09629967 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03550527 0,09618624 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03550527 0,09607308 ! axonal fasciculation GO:0007413 9 6 0,000 0,03550527 0,09596019 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03550527 0,09584756 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03550527 0,09573519 ! midbrain development GO:0030901 6 6 0,000 0,03550527 0,09562309 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03550527 0,09551125 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03550527 0,09539967 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03550527 0,09528835 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03550527 0,0951773 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03550527 0,0950665 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03550527 0,09495595 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03550527 0,09484567 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03550527 0,09473564 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03550527 0,09462586 ! adult feeding behavior GO:0008343 6 6 0,000 0,03550527 0,09451634 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03550527 0,09440708 ! pigment granule transport GO:0051904 12 6 0,000 0,03550527 0,09429806 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03550527 0,0941893 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03550527 0,09408078 ! catecholamine transport GO:0051937 7 6 0,000 0,03550527 0,09397252 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03550527 0,09386451 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03550527 0,09375674 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03550527 0,09364922 ! protein prenylation GO:0018342 10 6 0,000 0,03550527 0,09354195 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03550527 0,09343492 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03550527 0,09332814 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03550527 0,0932216 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03550527 0,0931153 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,03631065 0,09511903 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,03631065 0,09501081 ! positive regulation of growth GO:0045927 67 50 1,000 0,03631065 0,09490285 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,03631065 0,09479513 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,03764755 0,09817388 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,03764755 0,0980627 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,03764755 0,09795177 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,03764755 0,09784109 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03900312 0,10124964 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,04037711 0,10469825 ! kidney development GO:0001822 90 53 1,000 0,04037711 0,10458035 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04130019 0,10685087 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04130019 0,10673082 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04130019 0,10661103 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04130019 0,10649151 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04130019 0,10637226 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04130019 0,10625327 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04130019 0,10613455 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04130019 0,1060161 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04130019 0,10589791 ! reproductive behavior GO:0019098 12 7 0,000 0,04130019 0,10577998 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04130019 0,10566232 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04130019 0,10554492 ! oligopeptide transport GO:0006857 11 7 0,000 0,04130019 0,10542778 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04130019 0,10531089 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04130019 0,10519427 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04130019 0,10507791 ! RNA methylation GO:0001510 11 7 0,000 0,04130019 0,1049618 ! pericardium development GO:0060039 8 7 0,000 0,04130019 0,10484594 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04130019 0,10473035 ! fibril organization GO:0043206 13 7 0,000 0,04130019 0,10461501 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04130019 0,10449992 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04130019 0,10438508 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04130019 0,1042705 ! lipoprotein transport GO:0042953 9 7 0,000 0,04130019 0,10415617 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04130019 0,10404209 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04130019 0,10392826 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04130019 0,10381467 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04130019 0,10370134 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04130019 0,10358825 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04130019 0,10347541 ! chemosensory behavior GO:0007635 9 7 0,000 0,04130019 0,10336281 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04130019 0,10325046 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04130019 0,10313836 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04130019 0,10302649 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04130019 0,10291487 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04130019 0,10280349 ! reflex GO:0060004 12 7 0,000 0,04130019 0,10269235 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04130019 0,10258145 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04130019 0,10247079 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04130019 0,10236037 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04130019 0,10225019 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04130019 0,10214024 ! spinal cord patterning GO:0021511 7 7 0,000 0,04130019 0,10203053 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04130019 0,10192106 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04130019 0,10181182 ! adrenal gland development GO:0030325 17 7 0,000 0,04130019 0,10170281 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04130019 0,10159404 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04130019 0,1014855 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04130019 0,10137719 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04130019 0,10126911 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04130019 0,10116126 ! endosome organization GO:0007032 10 7 0,000 0,04130019 0,10105364 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04130019 0,10094626 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04130019 0,10083909 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04130019 0,10073216 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04130019 0,10062545 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04130019 0,10051897 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04130019 0,10041271 ! galactose metabolic process GO:0006012 10 7 0,000 0,04130019 0,10030668 ! vesicle fusion GO:0006906 15 7 0,000 0,04130019 0,10020087 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04130019 0,10009529 GO:0045851|pH reduction, ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04130019 0,09998992 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04130019 0,09988478 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04130019 0,09977986 ! retinol metabolic process GO:0042572 9 7 0,000 0,04130019 0,09967516 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04130019 0,09957068 ! rRNA modification GO:0000154 12 7 0,000 0,04130019 0,09946641 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04130019 0,09936237 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04130019 0,09925854 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04130019 0,09915493 ! intermediate filament organization GO:0045109 11 7 0,000 0,04130019 0,09905154 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04130019 0,09894836 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04130019 0,0988454 ! fibrinolysis GO:0042730 9 7 0,000 0,04130019 0,09874265 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,04130019 0,09864011 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04130019 0,09853779 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04130019 0,09843567 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04130019 0,09833377 ! response to tropane GO:0014073 13 7 0,000 0,04130019 0,09823208 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04130019 0,09813061 ! melanosome localization GO:0032400 10 7 0,000 0,04130019 0,09802934 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04130019 0,09792827 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04130019 0,09782742 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04130019 0,09772678 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04130019 0,09762634 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04130019 0,0975261 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04130019 0,09742608 ! mast cell activation GO:0045576 9 7 0,000 0,04130019 0,09732626 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04130019 0,09722664 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04130019 0,09712723 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04130019 0,09702801 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04130019 0,09692901 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04130019 0,0968302 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04130019 0,09673159 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04130019 0,09663319 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04130019 0,09653499 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04130019 0,09643698 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04130019 0,09633917 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04130019 0,09624157 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04130019 0,09614416 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04130019 0,09604694 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04130019 0,09594993 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04130019 0,0958531 ! diuresis GO:0030146 12 7 0,000 0,04130019 0,09575648 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04130019 0,09566005 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04130019 0,09556381 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04130019 0,09546776 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04130019 0,09537191 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04130019 0,09527625 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04130019 0,09518079 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04130019 0,09508551 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04130019 0,09499043 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04130019 0,09489553 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04130019 0,09480082 ! lymph node development GO:0048535 9 7 0,000 0,04130019 0,09470631 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04130019 0,09461198 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04130019 0,09451784 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04130019 0,09442388 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04130019 0,09433012 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04130019 0,09423653 ! ATP catabolic process GO:0006200 10 7 0,000 0,04130019 0,09414314 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04130019 0,09404993 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04130019 0,0939569 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04130019 0,09386406 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04130019 0,0937714 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04130019 0,09367892 ! muscle adaptation GO:0043500 12 7 0,000 0,04130019 0,09358663 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04130019 0,09349451 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04130019 0,09340258 ! retina homeostasis GO:0001895 9 7 0,000 0,04130019 0,09331083 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04130019 0,09321926 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04130019 0,09312787 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04130019 0,09303666 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04130019 0,09294562 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04130019 0,09285477 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04130019 0,09276409 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04130019 0,09267359 ! regulation of mitosis GO:0007088 84 54 1,000 0,04176924 0,09363476 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,04176924 0,09354358 ! detection of external stimulus GO:0009581 66 54 1,000 0,04176924 0,09345259 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,04176924 0,09336177 ! chromosome segregation GO:0007059 83 57 1,000 0,04605191 0,10283435 ! secondary metabolic process GO:0019748 84 57 1,000 0,04605191 0,10273461 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,04605191 0,10263506 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04706061 0,10478162 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04706061 0,10468028 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04706061 0,10457914 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04706061 0,1044782 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04706061 0,10437745 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04706061 0,10427689 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04706061 0,10417653 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04706061 0,10407636 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04706061 0,10397638 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,04706061 0,10387659 ! phosphate transport GO:0006817 10 8 0,000 0,04706061 0,103777 ! N-glycan processing GO:0006491 12 8 0,000 0,04706061 0,1036776 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04706061 0,10357838 ! UTP metabolic process GO:0046051 8 8 0,000 0,04706061 0,10347936 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04706061 0,10338053 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04706061 0,10328188 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04706061 0,10318342 ! succinate metabolic process GO:0006105 14 8 0,000 0,04706061 0,10308515 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,04706061 0,10298707 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04706061 0,10288917 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04706061 0,10279146 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04706061 0,10269394 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04706061 0,1025966 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04706061 0,10249944 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04706061 0,10240247 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04706061 0,10230568 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,04706061 0,10220908 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04706061 0,10211265 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04706061 0,10201641 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04706061 0,10192035 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04706061 0,10182447 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04706061 0,10172877 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04706061 0,10163325 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,04706061 0,10153791 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04706061 0,10144275 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04706061 0,10134776 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04706061 0,10125296 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04706061 0,10115833 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04706061 0,10106388 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04706061 0,1009696 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04706061 0,1008755 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04706061 0,10078157 ! macrophage activation GO:0042116 12 8 0,000 0,04706061 0,10068782 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04706061 0,10059425 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04706061 0,10050085 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04706061 0,10040762 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04706061 0,10031456 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04706061 0,10022168 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04706061 0,10012896 ! ruffle organization GO:0031529 11 8 0,000 0,04706061 0,10003642 ! osteoblast development GO:0002076 13 8 0,000 0,04706061 0,09994405 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04706061 0,09985185 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04706061 0,09975983 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04706061 0,09966797 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04706061 0,09957627 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04706061 0,09948475 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04706061 0,0993934 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04706061 0,09930221 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04706061 0,09921119 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04706061 0,09912034 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,04706061 0,09902965 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,04706061 0,09893913 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04706061 0,09884878 ! segment specification GO:0007379 10 8 0,000 0,04706061 0,09875859 ! cellular extravasation GO:0045123 11 8 0,000 0,04706061 0,09866856 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04706061 0,0985787 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04706061 0,098489 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04706061 0,09839946 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04706061 0,09831009 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04706061 0,09822088 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04706061 0,09813183 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04706061 0,09804294 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04706061 0,09795422 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04706061 0,09786565 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04706061 0,09777725 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04706061 0,097689 ! icosanoid secretion GO:0032309 12 8 0,000 0,04706061 0,09760091 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04706061 0,09751298 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04706061 0,09742521 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04706061 0,0973376 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04706061 0,09725014 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04706061 0,09716285 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04706061 0,0970757 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04706061 0,09698872 ! sterol catabolic process GO:0016127 9 8 0,000 0,04706061 0,09690189 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04706061 0,09681522 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04706061 0,0967287 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04706061 0,09664233 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04706061 0,09655612 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04706061 0,09647006 ! prophase GO:0051324 11 8 0,000 0,04706061 0,09638416 ! S phase GO:0051320 8 8 0,000 0,04706061 0,09629841 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04706061 0,09621281 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04706061 0,09612736 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04706061 0,09604207 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04706061 0,09595692 ! hormone catabolic process GO:0042447 13 8 0,000 0,04706061 0,09587193 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04706061 0,09578709 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04706061 0,0957024 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04706061 0,09561785 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04706061 0,09553346 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04706061 0,09544922 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04706061 0,09536512 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04706061 0,09528117 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04706061 0,09519737 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04706061 0,09511372 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04706061 0,09503021 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04706061 0,09494685 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04706061 0,09486364 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04706061 0,09478057 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,04899299 0,09858608 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,05200051 0,10454647 ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,05200051 0,10445517 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,05200051 0,10436402 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05278676 0,10584964 ! regulation of developmental growth GO:0048638 13 9 0,000 0,05278676 0,10575744 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,05278676 0,1056654 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05278676 0,10557351 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05278676 0,10548179 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05278676 0,10539023 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05278676 0,10529882 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05278676 0,10520757 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05278676 0,10511649 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05278676 0,10502555 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,05278676 0,10493478 ! GTP metabolic process GO:0046039 9 9 0,000 0,05278676 0,10484416 ! social behavior GO:0035176 14 9 0,000 0,05278676 0,1047537 ! artery development GO:0060840 19 9 0,000 0,05278676 0,1046634 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05278676 0,10457325 ! regulation of glycolysis GO:0006110 15 9 0,000 0,05278676 0,10448325 ! response to pain GO:0048265 16 9 0,000 0,05278676 0,10439341 ! protein complex disassembly GO:0043241 17 9 0,000 0,05278676 0,10430373 GO:0043624|cellular protein complex disassembly, ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05278676 0,1042142 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05278676 0,10412482 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05278676 0,1040356 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,05278676 0,10394653 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05278676 0,10385761 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05278676 0,10376884 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05278676 0,10368022 ! protein targeting to ER GO:0045047 19 9 0,000 0,05278676 0,10359176 ! endoderm development GO:0007492 12 9 0,000 0,05278676 0,10350345 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05278676 0,10341528 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05278676 0,10332727 ! arginine catabolic process GO:0006527 10 9 0,000 0,05278676 0,10323941 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05278676 0,10315169 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05278676 0,10306413 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05278676 0,10297671 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05278676 0,10288944 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05278676 0,10280232 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05278676 0,10271535 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05278676 0,10262852 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05278676 0,10254184 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05278676 0,10245531 ! mannose metabolic process GO:0006013 9 9 0,000 0,05278676 0,10236892 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05278676 0,10228268 ! receptor clustering GO:0043113 15 9 0,000 0,05278676 0,10219658 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05278676 0,10211063 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05278676 0,10202482 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05278676 0,10193916 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05278676 0,10185364 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05278676 0,10176827 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,05278676 0,10168303 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05278676 0,10159794 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,05278676 0,10151299 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05278676 0,10142819 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05278676 0,10134352 ! DNA ligation GO:0006266 14 9 0,000 0,05278676 0,101259 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05278676 0,10117462 ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05278676 0,10109038 ! erythrocyte development GO:0048821 11 9 0,000 0,05278676 0,10100627 ! renal water homeostasis GO:0003091 14 9 0,000 0,05278676 0,10092231 ! mRNA cleavage GO:0006379 13 9 0,000 0,05278676 0,10083849 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05278676 0,10075481 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05278676 0,10067126 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05278676 0,10058786 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05278676 0,10050459 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05278676 0,10042146 ! acid secretion GO:0046717 14 9 0,000 0,05278676 0,10033846 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05278676 0,10025561 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05278676 0,10017289 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05278676 0,10009031 ! purine base metabolic process GO:0006144 18 9 0,000 0,05278676 0,10000786 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05278676 0,09992555 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,05278676 0,09984337 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05278676 0,09976133 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05278676 0,09967943 ! detection of calcium ion GO:0005513 13 9 0,000 0,05278676 0,09959765 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05278676 0,09951602 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05278676 0,09943451 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05278676 0,09935314 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05278676 0,09927191 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05278676 0,0991908 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05278676 0,09910983 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05278676 0,09902899 ! prepulse inhibition GO:0060134 14 9 0,000 0,05278676 0,09894828 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05278676 0,0988677 ! insulin secretion GO:0030073 17 9 0,000 0,05278676 0,09878726 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05278676 0,09870694 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05278676 0,09862676 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05278676 0,09854671 ! localization within membrane GO:0051668 15 9 0,000 0,05278676 0,09846678 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,05352855 0,09976959 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,05507246 0,1025641 GO:0090046|regulation of transcription regulator activity, ! regulation of lipase activity GO:0060191 109 63 1,000 0,05507246 0,10248112 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,056632 0,10529798 ! adaptive immune response GO:0002250 94 64 1,000 0,056632 0,10521293 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,05820692 0,10805159 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,05820692 0,10796446 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,05820692 0,10787746 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,05847882 0,10829411 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05847882 0,10820699 ! neuron fate specification GO:0048665 11 10 0,000 0,05847882 0,10812 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05847882 0,10803316 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05847882 0,10794645 ! thyroid gland development GO:0030878 19 10 0,000 0,05847882 0,10785989 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05847882 0,10777346 ! synapsis GO:0007129 13 10 0,000 0,05847882 0,10768718 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05847882 0,10760103 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05847882 0,10751501 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05847882 0,10742914 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,05847882 0,1073434 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05847882 0,1072578 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,05847882 0,10717234 ! phospholipid efflux GO:0033700 16 10 0,000 0,05847882 0,10708701 ! hippocampus development GO:0021766 19 10 0,000 0,05847882 0,10700182 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,05847882 0,10691676 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05847882 0,10683184 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05847882 0,10674705 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,05847882 0,1066624 GO:0010812|negative regulation of cell-substrate adhesion, ! pathogenesis GO:0009405 13 10 0,000 0,05847882 0,10657788 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05847882 0,10649349 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05847882 0,10640924 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05847882 0,10632512 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05847882 0,10624114 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05847882 0,10615729 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05847882 0,10607357 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05847882 0,10598998 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05847882 0,10590652 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05847882 0,1058232 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05847882 0,10574 ! forebrain cell migration GO:0021885 17 10 0,000 0,05847882 0,10565694 ! lipid digestion GO:0044241 15 10 0,000 0,05847882 0,10557401 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05847882 0,1054912 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05847882 0,10540853 ! UV protection GO:0009650 14 10 0,000 0,05847882 0,10532598 ! entry into host cell GO:0030260 20 10 0,000 0,05847882 0,10524357 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05847882 0,10516128 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,05847882 0,10507913 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05847882 0,1049971 ! regulation of organ growth GO:0046620 11 10 0,000 0,05847882 0,1049152 ! response to dsRNA GO:0043331 18 10 0,000 0,05847882 0,10483342 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05847882 0,10475178 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05847882 0,10467026 ! embryonic axis specification GO:0000578 12 10 0,000 0,05847882 0,10458887 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05847882 0,1045076 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05847882 0,10442646 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05847882 0,10434545 ! cranial nerve development GO:0021545 12 10 0,000 0,05847882 0,10426456 ! fucose catabolic process GO:0019317 16 10 0,000 0,05847882 0,1041838 GO:0042355|L-fucose catabolic process, ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05847882 0,10410316 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05847882 0,10402265 ! zymogen activation GO:0031638 14 10 0,000 0,05847882 0,10394226 ! salivary gland development GO:0007431 22 10 0,000 0,05847882 0,10386199 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05847882 0,10378185 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05847882 0,10370184 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05847882 0,10362194 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05847882 0,10354217 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05847882 0,10346253 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05847882 0,103383 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05847882 0,1033036 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05847882 0,10322432 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,05847882 0,10314516 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05847882 0,10306612 ! detection of bacterium GO:0016045 10 10 0,000 0,05847882 0,1029872 ! embryonic gut development GO:0048566 11 10 0,000 0,05847882 0,1029084 ! activation of innate immune response GO:0002218 10 10 0,000 0,05847882 0,10282973 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05847882 0,10275117 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05847882 0,10267273 ! developmental induction GO:0031128 13 10 0,000 0,05847882 0,10259442 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05847882 0,10251622 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05847882 0,10243814 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05847882 0,10236018 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05847882 0,10228234 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,059797 0,10450843 ! axon guidance GO:0007411 99 66 1,000 0,059797 0,10442907 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,059797 0,10434984 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,06140198 0,10706942 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,06140198 0,1069883 ! learning or memory GO:0007611 123 68 1,000 0,06302165 0,10972733 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,06302165 0,10964432 ! rhythmic process GO:0048511 105 68 1,000 0,06302165 0,10956145 ! rRNA transcription GO:0009303 17 11 0,000 0,064137 0,11141624 ! respiratory burst GO:0045730 14 11 0,000 0,064137 0,11133215 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,064137 0,11124819 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,064137 0,11116435 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,064137 0,11108065 ! virus-host interaction GO:0019048 17 11 0,000 0,064137 0,11099706 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,064137 0,11091361 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,064137 0,11083028 ! mating GO:0007618 14 11 0,000 0,064137 0,11074707 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,064137 0,11066399 ! T cell proliferation GO:0042098 20 11 0,000 0,064137 0,11058103 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,064137 0,1104982 ! bone resorption GO:0045453 16 11 0,000 0,064137 0,11041549 ! regulated secretory pathway GO:0045055 14 11 0,000 0,064137 0,11033291 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,064137 0,11025045 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,064137 0,11016811 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,064137 0,11008589 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,064137 0,1100038 ! syncytium formation GO:0006949 15 11 0,000 0,064137 0,10992183 ! plasma membrane organization GO:0007009 18 11 0,000 0,064137 0,10983998 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,064137 0,10975826 ! mitotic spindle organization GO:0007052 15 11 0,000 0,064137 0,10967665 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,064137 0,10959517 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,064137 0,10951381 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,064137 0,10943256 ! adult heart development GO:0007512 11 11 0,000 0,064137 0,10935144 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,064137 0,10927044 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,064137 0,10918956 ! temperature homeostasis GO:0001659 16 11 0,000 0,064137 0,1091088 ! L-glutamate transport GO:0015813 16 11 0,000 0,064137 0,10902816 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,064137 0,10894763 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,064137 0,10886723 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,064137 0,10878694 ! stem cell development GO:0048864 29 11 0,000 0,064137 0,10870678 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,064137 0,10862673 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,064137 0,1085468 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,064137 0,10846698 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,064137 0,10838729 ! vasoconstriction GO:0042310 15 11 0,000 0,064137 0,10830771 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,064137 0,10822824 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,064137 0,1081489 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,064137 0,10806967 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,064137 0,10799055 ! ribosome assembly GO:0042255 13 11 0,000 0,064137 0,10791156 ! histone deacetylation GO:0016575 13 11 0,000 0,064137 0,10783267 ! chromatin silencing GO:0006342 19 11 0,000 0,064137 0,10775391 ! nucleosome positioning GO:0016584 13 11 0,000 0,064137 0,10767525 ! regulation of isotype switching GO:0045191 19 11 0,000 0,064137 0,10759672 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,064137 0,10751829 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,064137 0,10743998 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,064137 0,10736179 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,064137 0,10728371 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,064137 0,10720574 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,064137 0,10712788 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,064137 0,10705014 ! male genitalia development GO:0030539 13 11 0,000 0,064137 0,10697251 ! cholesterol efflux GO:0033344 19 11 0,000 0,064137 0,106895 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,064137 0,10681759 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,064137 0,1067403 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,064137 0,10666312 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,064137 0,10658605 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,064137 0,1065091 ! defense response to fungus GO:0050832 12 11 0,000 0,064137 0,10643225 ! lysogeny GO:0030069 18 11 0,000 0,064137 0,10635551 GO:0019047|provirus integration, ! acrosome reaction GO:0007340 13 11 0,000 0,064137 0,10627889 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,064137 0,10620237 ! sensory perception of chemical stimulus GO:0007606 85 69 1,000 0,06465577 0,10698437 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,06465577 0,10690746 ! humoral immune response GO:0006959 86 70 1,000 0,06630411 0,10955421 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,06630411 0,10947556 ! regulation of catabolic process GO:0009894 106 70 1,000 0,06630411 0,10939703 ! muscle cell differentiation GO:0042692 104 71 1,000 0,06796645 0,11205938 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,06796645 0,11197911 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,06964256 0,11465848 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,06964256 0,11457646 ! lactation GO:0007595 20 12 0,000 0,0697615 0,1146901 ! reproductive cellular process GO:0048610 14 12 0,000 0,0697615 0,11460817 ! tRNA modification GO:0006400 14 12 0,000 0,0697615 0,11452637 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,0697615 0,11444468 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,0697615 0,11436311 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,0697615 0,11428166 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,0697615 0,11420032 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,0697615 0,11411909 ! non-recombinational repair GO:0000726 19 12 0,000 0,0697615 0,11403798 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,0697615 0,11395699 ! peroxisomal transport GO:0043574 21 12 0,000 0,0697615 0,11387611 ! cartilage condensation GO:0001502 18 12 0,000 0,0697615 0,11379535 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,0697615 0,1137147 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,0697615 0,11363417 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,0697615 0,11355375 ! heart looping GO:0001947 15 12 0,000 0,0697615 0,11347344 ! palate development GO:0060021 15 12 0,000 0,0697615 0,11339325 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,0697615 0,11331317 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,0697615 0,1132332 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,0697615 0,11315335 ! arginine metabolic process GO:0006525 13 12 0,000 0,0697615 0,1130736 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,0697615 0,11299397 ! methionine metabolic process GO:0006555 13 12 0,000 0,0697615 0,11291446 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,0697615 0,11283505 ! Golgi organization GO:0007030 18 12 0,000 0,0697615 0,11275576 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,0697615 0,11267658 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,0697615 0,1125975 ! monoamine transport GO:0015844 13 12 0,000 0,0697615 0,11251854 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0697615 0,11243969 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,0697615 0,11236096 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,0697615 0,11228233 ! L-amino acid transport GO:0015807 20 12 0,000 0,0697615 0,11220381 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,0697615 0,1121254 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,0697615 0,1120471 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,0697615 0,11196891 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,0697615 0,11189083 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,0697615 0,11181285 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,0697615 0,11173499 ! cerebellum development GO:0021549 13 12 0,000 0,0697615 0,11165723 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,0697615 0,11157959 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,0697615 0,11150205 ! histone acetylation GO:0016573 23 12 0,000 0,0697615 0,11142461 ! histone methylation GO:0016571 15 12 0,000 0,0697615 0,11134729 ! autonomic nervous system development GO:0048483 23 12 0,000 0,0697615 0,11127007 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,0697615 0,11119296 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,0697615 0,11111596 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,0697615 0,11103906 ! regulation of epidermis development GO:0045682 17 12 0,000 0,0697615 0,11096227 ! intestinal absorption GO:0050892 19 12 0,000 0,0697615 0,11088559 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,0697615 0,11080901 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,0697615 0,11073254 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,0697615 0,11065617 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,0697615 0,11057991 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,0697615 0,11050375 ! response to cold GO:0009409 14 12 0,000 0,0697615 0,1104277 ! regulation of blood pressure GO:0008217 107 73 1,000 0,07133223 0,1128364 ! digestion GO:0007586 97 74 1,000 0,07303522 0,11545087 ! regulation of ligase activity GO:0051340 114 75 1,000 0,07475133 0,11808246 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07535251 0,11895043 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07535251 0,11886885 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07535251 0,11878737 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,07535251 0,11870601 ! water transport GO:0006833 17 13 0,000 0,07535251 0,11862476 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07535251 0,11854363 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07535251 0,1184626 ! lipid localization GO:0010876 24 13 0,000 0,07535251 0,11838168 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07535251 0,11830087 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07535251 0,11822018 ! organelle fusion GO:0048284 28 13 0,000 0,07535251 0,11813959 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07535251 0,11805911 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,07535251 0,11797875 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,07535251 0,11789849 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,07535251 0,11781834 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07535251 0,1177383 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07535251 0,11765837 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,07535251 0,11757855 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07535251 0,11749883 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07535251 0,11741923 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07535251 0,11733973 ! NAD metabolic process GO:0019674 21 13 0,000 0,07535251 0,11726034 ! exocrine system development GO:0035272 27 13 0,000 0,07535251 0,11718105 ! regulation of exocytosis GO:0017157 17 13 0,000 0,07535251 0,11710188 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,07535251 0,11702281 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07535251 0,11694385 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07535251 0,11686499 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,07535251 0,11678624 ! genitalia development GO:0048806 15 13 0,000 0,07535251 0,1167076 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,07535251 0,11662906 ! tissue regeneration GO:0042246 21 13 0,000 0,07535251 0,11655063 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,07535251 0,1164723 ! cofactor transport GO:0051181 19 13 0,000 0,07535251 0,11639408 ! NADP metabolic process GO:0006739 18 13 0,000 0,07535251 0,11631596 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07535251 0,11623795 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,07535251 0,11616004 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07535251 0,11608224 ! gas transport GO:0015669 18 13 0,000 0,07535251 0,11600454 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07535251 0,11592694 ! regulation of axon extension GO:0030516 23 13 0,000 0,07535251 0,11584945 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07535251 0,11577206 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07535251 0,11569478 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07535251 0,1156176 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07535251 0,11554052 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07535251 0,11546354 ! regulation of DNA binding GO:0051101 119 77 1,000 0,07822204 0,11978075 ! protein ubiquitination GO:0016567 125 77 1,000 0,07822204 0,11970105 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,07822204 0,11962146 ! superoxide anion generation GO:0042554 18 14 0,000 0,08091024 0,12365021 ! neuron maturation GO:0042551 21 14 0,000 0,08091024 0,1235681 ! myotube differentiation GO:0014902 21 14 0,000 0,08091024 0,1234861 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,08091024 0,12340422 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08091024 0,12332244 ! inositol metabolic process GO:0006020 20 14 0,000 0,08091024 0,12324077 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08091024 0,12315921 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08091024 0,12307775 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08091024 0,1229964 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08091024 0,12291516 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08091024 0,12283403 ! response to cAMP GO:0051591 19 14 0,000 0,08091024 0,12275301 ! limbic system development GO:0021761 25 14 0,000 0,08091024 0,12267209 ! startle response GO:0001964 21 14 0,000 0,08091024 0,12259128 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,08091024 0,12251057 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08091024 0,12242997 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,08091024 0,12234948 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08091024 0,12226909 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08091024 0,12218881 ! glycine metabolic process GO:0006544 22 14 0,000 0,08091024 0,12210863 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,08091024 0,12202856 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,08091024 0,1219486 ! regulation of heart rate GO:0002027 23 14 0,000 0,08091024 0,12186874 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08091024 0,12178898 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08091024 0,12170933 ! embryo implantation GO:0007566 27 14 0,000 0,08091024 0,12162978 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08091024 0,12155033 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08091024 0,12147099 ! axon cargo transport GO:0008088 27 14 0,000 0,08091024 0,12139175 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08091024 0,12131262 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,08091024 0,12123359 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08091024 0,12115466 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08091024 0,12107584 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08091024 0,12099711 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08091024 0,12091849 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,08091024 0,12083997 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08091024 0,12076156 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08091024 0,12068324 ! muscle maintenance GO:0046716 19 14 0,000 0,08091024 0,12060503 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08091024 0,12052692 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08091024 0,12044891 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08091024 0,120371 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,08091024 0,12029319 ! cell killing GO:0001906 20 14 0,000 0,08091024 0,12021548 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,08091024 0,12013787 ! cilium assembly GO:0042384 20 14 0,000 0,08091024 0,12006036 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08091024 0,11998295 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,08352113 0,12377487 GO:0010498|proteasomal protein catabolic process, ! positive regulation of cell size GO:0045793 20 15 0,000 0,08643488 0,12801045 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,08643488 0,12792808 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,08643488 0,12784581 ! skin development GO:0043588 25 15 0,000 0,08643488 0,12776365 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08643488 0,12768159 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,08643488 0,12759964 ! lipid phosphorylation GO:0046834 23 15 0,000 0,08643488 0,12751779 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08643488 0,12743605 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08643488 0,12735441 ! bile acid metabolic process GO:0008206 22 15 0,000 0,08643488 0,12727288 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08643488 0,12719145 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08643488 0,12711012 ! adult walking behavior GO:0007628 25 15 0,000 0,08643488 0,1270289 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08643488 0,12694779 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,08643488 0,12686677 ! myoblast differentiation GO:0045445 27 15 0,000 0,08643488 0,12678586 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,08643488 0,12670506 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08643488 0,12662435 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08643488 0,12654375 ! cerebral cortex development GO:0021987 29 15 0,000 0,08643488 0,12646325 ! response to osmotic stress GO:0006970 22 15 0,000 0,08643488 0,12638286 ! vesicle coating GO:0006901 25 15 0,000 0,08643488 0,12630256 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,08643488 0,12622237 ! DNA integration GO:0015074 22 15 0,000 0,08643488 0,12614228 ! peptide secretion GO:0002790 27 15 0,000 0,08643488 0,12606229 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08643488 0,1259824 ! regulation of vasodilation GO:0042312 24 15 0,000 0,08643488 0,12590262 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,08643488 0,12582293 ! neuron recognition GO:0008038 22 15 0,000 0,08643488 0,12574335 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08643488 0,12566386 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,08643488 0,12558448 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08643488 0,1255052 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,08643488 0,12542601 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,08643488 0,12534693 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,08643488 0,12526795 ! dopamine metabolic process GO:0042417 30 15 0,000 0,08643488 0,12518906 ! organic cation transport GO:0015695 19 15 0,000 0,08643488 0,12511028 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08643488 0,12503159 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,08643488 0,12495301 ! peptide hormone processing GO:0016486 19 15 0,000 0,08643488 0,12487452 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,08643488 0,12479613 ! ossification GO:0001503 134 82 1,000 0,08711347 0,12569697 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,08711347 0,12561817 ! protein secretion GO:0009306 27 16 0,000 0,09192663 0,13247572 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,09192663 0,13239277 ! hormone secretion GO:0046879 25 16 0,000 0,09192663 0,13230992 ! bone remodeling GO:0046849 24 16 0,000 0,09192663 0,13222717 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,09192663 0,13214453 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,09192663 0,13206199 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09192663 0,13197956 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,09192663 0,13189722 ! glial cell development GO:0021782 24 16 0,000 0,09192663 0,13181499 ! patterning of blood vessels GO:0001569 24 16 0,000 0,09192663 0,13173287 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,09192663 0,13165084 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,09192663 0,13156892 ! protein polyubiquitination GO:0000209 26 16 0,000 0,09192663 0,1314871 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,09192663 0,13140538 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,09192663 0,13132376 ! fructose metabolic process GO:0006000 20 16 0,000 0,09192663 0,13124224 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,09192663 0,13116082 ! protein export from nucleus GO:0006611 24 16 0,000 0,09192663 0,13107951 ! negative regulation of immune response GO:0050777 28 16 0,000 0,09192663 0,1309983 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,09192663 0,13091718 ! DNA replication initiation GO:0006270 25 16 0,000 0,09192663 0,13083617 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,09192663 0,13075526 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,09192663 0,13067444 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,09192663 0,13059373 ! neural crest cell migration GO:0001755 24 16 0,000 0,09192663 0,13051312 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,09192663 0,1304326 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,09192663 0,13035219 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,09192663 0,13027187 ! steroid catabolic process GO:0006706 22 16 0,000 0,09192663 0,13019166 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,09192663 0,13011154 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,09192663 0,13003152 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,09192663 0,1299516 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,09192663 0,12987178 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,09192663 0,12979205 ! sperm-egg recognition GO:0035036 16 16 0,000 0,09192663 0,12971242 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,09192663 0,12963289 ! nerve development GO:0021675 18 16 0,000 0,09192663 0,12955346 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,09192663 0,12947413 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,09192663 0,12939489 ! negative regulation of translation GO:0017148 22 16 0,000 0,09192663 0,12931575 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,09258734 0,13016558 ! transcription initiation GO:0006352 118 85 1,000 0,09258734 0,13008607 ! cellular defense response GO:0006968 102 87 1,000 0,0962912 0,13520743 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,0962912 0,13512493 GO:0060538|skeletal muscle organ development, ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,09738568 0,13657747 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,09738568 0,13649425 ! negative regulation of defense response GO:0031348 19 17 0,000 0,09738568 0,13641112 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,09738568 0,13632809 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,09738568 0,13624517 ! glycerol metabolic process GO:0006071 20 17 0,000 0,09738568 0,13616234 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,09738568 0,13607962 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,09738568 0,135997 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,09738568 0,13591448 ! signal complex assembly GO:0007172 29 17 0,000 0,09738568 0,13583205 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,09738568 0,13574973 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,09738568 0,13566751 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,09738568 0,13558539 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,09738568 0,13550336 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,09738568 0,13542144 ! memory GO:0007613 25 17 0,000 0,09738568 0,13533961 ! keratinization GO:0031424 17 17 0,000 0,09738568 0,13525788 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,09738568 0,13517626 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,09738568 0,13509473 ! retinoid metabolic process GO:0001523 22 17 0,000 0,09738568 0,13501329 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,09738568 0,13493196 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,09738568 0,13485073 ! vacuolar transport GO:0007034 24 17 0,000 0,09738568 0,13476959 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,09738568 0,13468855 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,09738568 0,13460761 ! membrane budding GO:0006900 29 17 0,000 0,09738568 0,13452676 ! heme metabolic process GO:0042168 27 17 0,000 0,09738568 0,13444601 ! actin filament bundle formation GO:0051017 26 17 0,000 0,09738568 0,13436536 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,09738568 0,13428481 ! body fluid secretion GO:0007589 27 17 0,000 0,09738568 0,13420435 ! stem cell differentiation GO:0048863 36 17 0,000 0,09738568 0,13412399 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,09738568 0,13404372 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,09738568 0,13396355 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,09738568 0,13388348 ! sensory perception of pain GO:0019233 23 17 0,000 0,09738568 0,1338035 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,09738568 0,13372362 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,09738568 0,13364383 ! synaptogenesis GO:0007416 24 17 0,000 0,09738568 0,13356414 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,09738568 0,13348454 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,09738568 0,13340504 ! cell-cell junction organization GO:0045216 25 17 0,000 0,09738568 0,13332563 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,09738568 0,13324632 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,09738568 0,1331671 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,09738568 0,13308797 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,09738568 0,13300894 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,09738568 0,13293 ! protein processing GO:0016485 114 88 1,000 0,09815894 0,13390602 ! hormone metabolic process GO:0042445 121 90 1,000 0,10192505 0,13896125 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,10281222 0,14008773 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,10281222 0,14000479 ! positive regulation of translation GO:0045727 28 18 0,000 0,10281222 0,13992195 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,10281222 0,13983921 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,10281222 0,13975656 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,10281222 0,13967401 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,10281222 0,13959156 ! cAMP metabolic process GO:0046058 33 18 0,000 0,10281222 0,1395092 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,10281222 0,13942694 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,10281222 0,13934478 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,10281222 0,13926272 ! axis specification GO:0009798 26 18 0,000 0,10281222 0,13918075 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,10281222 0,13909888 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,10281222 0,13901711 ! pancreas development GO:0031016 26 18 0,000 0,10281222 0,13893543 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,10281222 0,13885384 ! glutamine metabolic process GO:0006541 23 18 0,000 0,10281222 0,13877236 ! response to retinoic acid GO:0032526 25 18 0,000 0,10281222 0,13869097 ! pigmentation during development GO:0048066 31 18 0,000 0,10281222 0,13860967 ! central nervous system neuron development GO:0021954 30 18 0,000 0,10281222 0,13852847 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,10281222 0,13844736 ! fucose metabolic process GO:0006004 26 18 0,000 0,10281222 0,13836635 ! response to fungus GO:0009620 19 18 0,000 0,10281222 0,13828544 ! peptide cross-linking GO:0018149 31 18 0,000 0,10281222 0,13820461 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,10281222 0,13812389 ! heart process GO:0003015 27 18 0,000 0,10281222 0,13804326 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,10281222 0,13796272 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,10281222 0,13788227 ! visual learning GO:0008542 35 18 0,000 0,10281222 0,13780192 ! somitogenesis GO:0001756 24 18 0,000 0,10281222 0,13772166 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,10281222 0,1376415 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,10281222 0,13756143 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,10281222 0,13748145 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,10281222 0,13740157 ! vitamin transport GO:0051180 24 18 0,000 0,10281222 0,13732177 ! hormone transport GO:0009914 27 18 0,000 0,10281222 0,13724208 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,10281222 0,13716247 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,10281222 0,13708295 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,10281222 0,13700353 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,10281222 0,1369242 ! cell-cell recognition GO:0009988 20 18 0,000 0,10281222 0,13684496 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,10281222 0,13676582 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,10281222 0,13668676 ! regulation of glucose import GO:0046324 21 18 0,000 0,10281222 0,1366078 GO:0010827|regulation of glucose transport, ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,10281222 0,13652892 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,10764808 0,1428682 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,10820644 0,14352642 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,10820644 0,14344369 ! positive regulation of ossification GO:0045778 30 19 0,000 0,10820644 0,14336107 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,10820644 0,14327853 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,10820644 0,14319609 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,10820644 0,14311375 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,10820644 0,1430315 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,10820644 0,14294935 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,10820644 0,14286728 ! smooth muscle contraction GO:0006939 36 19 0,000 0,10820644 0,14278532 ! peroxisome organization GO:0007031 29 19 0,000 0,10820644 0,14270345 ! digestive system process GO:0022600 30 19 0,000 0,10820644 0,14262167 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,10820644 0,14253998 ! response to vitamin A GO:0033189 26 19 0,000 0,10820644 0,14245839 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,10820644 0,14237689 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,10820644 0,14229549 ! sex determination GO:0007530 29 19 0,000 0,10820644 0,14221418 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,10820644 0,14213296 ! plasma membrane fusion GO:0045026 23 19 0,000 0,10820644 0,14205183 ! cytolysis GO:0019835 20 19 0,000 0,10820644 0,1419708 ! vasodilation GO:0042311 33 19 0,000 0,10820644 0,14188986 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,10820644 0,14180901 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,10820644 0,14172825 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,10820644 0,14164759 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,10820644 0,14156701 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,10820644 0,14148653 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,10820644 0,14140614 ! sarcomere organization GO:0045214 23 19 0,000 0,10820644 0,14132584 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,10820644 0,14124564 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,10820644 0,14116552 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,10820644 0,14108549 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,10820644 0,14100556 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,10820644 0,14092571 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,10820644 0,14084596 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,10820644 0,1407663 ! protein stabilization GO:0050821 26 19 0,000 0,10820644 0,14068672 ! angiogenesis GO:0001525 149 95 1,000 0,11151054 0,1449007 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,11345536 0,14734462 ! protein maturation GO:0051604 129 96 1,000 0,11345536 0,14726147 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,11356854 0,14732523 ! iron ion transport GO:0006826 37 20 0,000 0,11356854 0,14724219 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,11356854 0,14715923 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,11356854 0,14707637 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,11356854 0,14699361 ! response to vitamin GO:0033273 29 20 0,000 0,11356854 0,14691093 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,11356854 0,14682835 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,11356854 0,14674586 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,11356854 0,14666347 ! spinal cord development GO:0021510 31 20 0,000 0,11356854 0,14658117 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,11356854 0,14649895 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,11356854 0,14641684 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,11356854 0,14633481 ! chromosome condensation GO:0030261 31 20 0,000 0,11356854 0,14625288 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,11356854 0,14617103 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,11356854 0,14608928 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,11356854 0,14600762 ! pallium development GO:0021543 38 20 0,000 0,11356854 0,14592605 ! collagen fibril organization GO:0030199 45 20 0,000 0,11356854 0,14584458 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,11356854 0,14576319 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,11356854 0,14568189 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,11356854 0,14560069 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,11356854 0,14551957 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,11356854 0,14543855 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,11356854 0,14535762 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,11356854 0,14527677 ! alditol metabolic process GO:0019400 24 20 0,000 0,11356854 0,14519602 ! actin filament-based movement GO:0030048 34 20 0,000 0,11356854 0,14511535 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,1188987 0,15184176 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,1188987 0,1517575 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,1188987 0,15167333 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,1188987 0,15158925 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,1188987 0,15150527 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,1188987 0,15142138 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,1188987 0,15133758 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,1188987 0,15125388 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,1188987 0,15117027 ! vesicle docking GO:0048278 27 21 0,000 0,1188987 0,15108675 ! phototransduction GO:0007602 25 21 0,000 0,1188987 0,15100332 ! dendrite development GO:0016358 35 21 0,000 0,1188987 0,15091998 ! visual behavior GO:0007632 39 21 0,000 0,1188987 0,15083674 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,1188987 0,15075359 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,1188987 0,15067053 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,1188987 0,15058756 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,1188987 0,15050468 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,1188987 0,1504219 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,1188987 0,1503392 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,1188987 0,1502566 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,1188987 0,15017409 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,1188987 0,15009166 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,1188987 0,15000933 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,1188987 0,14992709 ! fatty acid transport GO:0015908 30 21 0,000 0,1188987 0,14984494 ! immunoglobulin production GO:0002377 33 21 0,000 0,1188987 0,14976288 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,1188987 0,1496809 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,1188987 0,14959902 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,1188987 0,14951723 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,1188987 0,14943552 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,1188987 0,14935391 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,1188987 0,14927239 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,1188987 0,14919095 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,1188987 0,1491096 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,1188987 0,14902834 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,1188987 0,14894717 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,1188987 0,14886609 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,1188987 0,1487851 ! regulation of translation GO:0006417 151 100 1,000 0,12132121 0,15173397 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,12132121 0,15165151 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,12419712 0,15516207 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,12419712 0,15507783 ! viral genome replication GO:0019079 29 22 0,000 0,12419712 0,15499369 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,12419712 0,15490963 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,12419712 0,15482567 ! leukocyte adhesion GO:0007159 38 22 0,000 0,12419712 0,1547418 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,12419712 0,15465802 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,12419712 0,15457433 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,12419712 0,15449073 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,12419712 0,15440723 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,12419712 0,15432381 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,12419712 0,15424048 ! lysosome organization GO:0007040 37 22 0,000 0,12419712 0,15415724 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,12419712 0,15407409 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,12419712 0,15399103 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,12419712 0,15390806 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,12419712 0,15382518 ! membrane depolarization GO:0051899 35 22 0,000 0,12419712 0,15374239 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,12419712 0,15365969 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,12419712 0,15357708 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,12419712 0,15349455 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,12419712 0,15341212 ! neural tube closure GO:0001843 33 22 0,000 0,12419712 0,15332977 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,12419712 0,15324751 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,12946397 0,15966066 ! neuron fate commitment GO:0048663 32 23 0,000 0,12946397 0,1595751 ! embryonic pattern specification GO:0009880 31 23 0,000 0,12946397 0,15948963 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,12946397 0,15940425 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,12946397 0,15931896 ! vesicle targeting GO:0006903 32 23 0,000 0,12946397 0,15923376 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,12946397 0,15914866 ! osteoblast differentiation GO:0001649 40 23 0,000 0,12946397 0,15906364 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,12946397 0,15897872 ! interaction with host GO:0051701 37 23 0,000 0,12946397 0,15889388 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,12946397 0,15880914 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,12946397 0,15872449 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,12946397 0,15863992 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,12946397 0,15855545 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,12946397 0,15847107 ! cell fate determination GO:0001709 45 23 0,000 0,12946397 0,15838677 ! pentose metabolic process GO:0019321 31 23 0,000 0,12946397 0,15830257 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,12946397 0,15821846 ! spermatid development GO:0007286 33 23 0,000 0,12946397 0,15813443 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,12946397 0,1580505 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,12946397 0,15796665 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,12946397 0,15788289 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,12946397 0,15779922 ! telomere organization GO:0032200 32 23 0,000 0,12946397 0,15771564 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,12946397 0,15763215 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,12946397 0,15754875 ! regulation of amine transport GO:0051952 38 23 0,000 0,12946397 0,15746543 ! liver development GO:0001889 40 23 0,000 0,12946397 0,15738221 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,13469945 0,16366019 ! initiation of viral infection GO:0019059 42 24 0,000 0,13469945 0,16357378 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,13469945 0,16348746 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,13469945 0,16340124 ! superoxide metabolic process GO:0006801 32 24 0,000 0,13469945 0,1633151 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,13469945 0,16322905 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,13469945 0,1631431 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,13469945 0,16305723 ! sperm motility GO:0030317 27 24 0,000 0,13469945 0,16297146 ! vacuole organization GO:0007033 39 24 0,000 0,13469945 0,16288578 ! receptor metabolic process GO:0043112 37 24 0,000 0,13469945 0,16280018 ! neural crest cell development GO:0014032 39 24 0,000 0,13469945 0,16271468 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,13469945 0,16262926 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,13469945 0,16254394 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,13469945 0,1624587 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,13469945 0,16237356 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,13469945 0,1622885 ! glutathione metabolic process GO:0006749 29 24 0,000 0,13469945 0,16220353 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,13469945 0,16211865 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,13469945 0,16203386 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,13990375 0,16820628 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,13990375 0,1681184 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,13990375 0,16803061 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,13990375 0,16794291 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,13990375 0,1678553 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,13990375 0,16776779 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,13990375 0,16768036 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 43 25 0,000 0,13990375 0,16759303 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,13990375 0,16750579 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,13990375 0,16741864 ! phospholipid transport GO:0015914 35 25 0,000 0,13990375 0,16733158 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,13990375 0,1672446 ! detection of light stimulus GO:0009583 30 25 0,000 0,13990375 0,16715772 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,13990375 0,16707093 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,13990375 0,16698423 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,14507704 0,17306908 ! translational initiation GO:0006413 43 26 0,000 0,14507704 0,17297936 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,14507704 0,17288973 ! circadian rhythm GO:0007623 42 26 0,000 0,14507704 0,1728002 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,14507704 0,17271076 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,14507704 0,17262141 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,14507704 0,17253215 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,14507704 0,17244299 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,14507704 0,17235392 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,14507704 0,17226494 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,14507704 0,17217605 ! regulation of coagulation GO:0050818 39 26 0,000 0,14507704 0,17208725 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,1502195 0,17809529 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,1502195 0,17800353 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,1502195 0,17791187 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,1502195 0,17782031 ! membrane docking GO:0022406 39 27 0,000 0,1502195 0,17772884 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,1502195 0,17763746 ! catechol metabolic process GO:0009712 43 27 0,000 0,1502195 0,17754618 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,1502195 0,17745499 ! acute-phase response GO:0006953 42 27 0,000 0,1502195 0,17736389 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,1502195 0,17727289 ! myofibril assembly GO:0030239 36 27 0,000 0,1502195 0,17718198 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,1502195 0,17709116 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,1502195 0,17700044 ! natural killer cell activation GO:0030101 35 27 0,000 0,1502195 0,17690981 ! lipid oxidation GO:0034440 38 27 0,000 0,1502195 0,17681927 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,1502195 0,17672883 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,1502195 0,17663848 ! gene silencing GO:0016458 41 27 0,000 0,1502195 0,17654822 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,15533133 0,18246275 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,15533133 0,18236961 ! phenol metabolic process GO:0018958 44 28 0,000 0,15533133 0,18227656 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,15533133 0,18218361 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,15533133 0,18209076 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,15533133 0,18199799 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,15533133 0,18190533 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,15533133 0,18181275 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,15533133 0,18172028 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,15533133 0,18162789 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,15533133 0,1815356 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,15533133 0,1814434 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,15533133 0,1813513 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,15533133 0,18125929 ! mesoderm formation GO:0001707 46 28 0,000 0,15533133 0,18116737 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,15533133 0,18107555 ! BMP signaling pathway GO:0030509 40 28 0,000 0,15533133 0,18098382 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,15533133 0,18089218 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,15533133 0,18080064 ! neural tube formation GO:0001841 41 28 0,000 0,15533133 0,18070919 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1604127 0,1865264 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,1604127 0,18643214 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1604127 0,18633799 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1604127 0,18624392 ! mismatch repair GO:0006298 34 29 0,000 0,1604127 0,18614996 ! muscle cell development GO:0055001 38 29 0,000 0,1604127 0,18605608 ! formation of primary germ layer GO:0001704 48 29 0,000 0,1604127 0,1859623 ! telencephalon development GO:0021537 52 29 0,000 0,1604127 0,18586862 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,1604127 0,18577503 ! eye morphogenesis GO:0048592 51 29 0,000 0,1604127 0,18568154 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1604127 0,18558813 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,16546379 0,1913357 ! organic anion transport GO:0015711 51 30 0,000 0,16546379 0,19123956 ! cholesterol transport GO:0030301 46 30 0,000 0,16546379 0,1911435 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,16546379 0,19104755 ! spliceosome assembly GO:0000245 49 30 0,000 0,16546379 0,19095169 ! spindle organization GO:0007051 37 30 0,000 0,16546379 0,19085593 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,16546379 0,19076026 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,16546379 0,19066469 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,16546379 0,19056921 ! ceramide metabolic process GO:0006672 43 30 0,000 0,16546379 0,19047383 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,16546379 0,19037855 ! adult locomotory behavior GO:0008344 47 30 0,000 0,16546379 0,19028336 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,16546379 0,19018826 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,16546379 0,19009327 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,16546379 0,18999836 ! negative regulation of secretion GO:0051048 49 31 0,000 0,17048478 0,19566616 ! glial cell differentiation GO:0010001 55 31 0,000 0,17048478 0,19556857 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,17048478 0,19547108 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,17048478 0,19537369 ! odontogenesis GO:0042476 50 31 0,000 0,17048478 0,19527639 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,17048478 0,19517919 ! segmentation GO:0035282 41 31 0,000 0,17048478 0,19508209 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,17048478 0,19498508 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,17048478 0,19488817 ! cell fate specification GO:0001708 37 31 0,000 0,17048478 0,19479135 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,17048478 0,19469463 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,17048478 0,19459801 ! RNA modification GO:0009451 40 31 0,000 0,17048478 0,19450148 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,17547585 0,2000964 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,17547585 0,19999725 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,17547585 0,19989819 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,17547585 0,19979923 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,17547585 0,19970037 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 0,000 0,17547585 0,1996016 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,17547585 0,19950294 ! cytokine production GO:0001816 44 32 0,000 0,17547585 0,19940437 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,17547585 0,1993059 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,17547585 0,19920752 ! vesicle localization GO:0051648 47 32 0,000 0,17547585 0,19910925 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,18043717 0,20463781 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,18043717 0,20453695 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,18043717 0,2044362 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,18043717 0,20433554 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,18043717 0,20423498 ! sister chromatid segregation GO:0000819 46 33 0,000 0,18043717 0,20413452 ! actomyosin structure organization GO:0031032 43 33 0,000 0,18043717 0,20403416 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,18043717 0,2039339 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,18043717 0,20383373 ! lipid homeostasis GO:0055088 55 33 0,000 0,18043717 0,20373367 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,18043717 0,2036337 ! regulation of proteolysis GO:0030162 50 33 0,000 0,18043717 0,20353383 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,18043717 0,20343406 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,18043717 0,20333439 ! mRNA catabolic process GO:0006402 48 34 0,000 0,18536892 0,20878967 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,18536892 0,20868747 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,18536892 0,20858537 ! feeding behavior GO:0007631 45 34 0,000 0,18536892 0,20848338 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,18536892 0,20838148 ! neuron migration GO:0001764 46 34 0,000 0,18536892 0,20827968 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,18536892 0,20817798 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,18536892 0,20807638 ! polyol metabolic process GO:0019751 44 34 0,000 0,18536892 0,20797488 ! aerobic respiration GO:0009060 47 34 0,000 0,18536892 0,20787348 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,18536892 0,20777218 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,18536892 0,20767097 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,18536892 0,20756987 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,19027127 0,21295568 ! Notch signaling pathway GO:0007219 56 35 0,000 0,19027127 0,2128521 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,19027127 0,21274862 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,19027127 0,21264525 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,19027127 0,21254197 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,19027127 0,2124388 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,19027127 0,21233572 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,19027127 0,21223274 ! glycogen metabolic process GO:0005977 48 35 0,000 0,19027127 0,21212987 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,19027127 0,21202709 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,1951444 0,21735212 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,1951444 0,21724691 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,1951444 0,21714181 ! organic ether metabolic process GO:0018904 46 36 0,000 0,1951444 0,21703681 ! neural tube development GO:0021915 50 36 0,000 0,1951444 0,21693191 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,1951444 0,21682711 ! glucan metabolic process GO:0044042 49 36 0,000 0,1951444 0,21672241 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,19998848 0,22199494 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,19998848 0,22188785 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,19998848 0,22178086 ! ion transmembrane transport GO:0034220 56 37 0,000 0,19998848 0,22167398 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,19998848 0,2215672 ! regulation of protein secretion GO:0050708 51 37 0,000 0,19998848 0,22146052 ! amino acid activation GO:0043038 52 37 0,000 0,19998848 0,22135395 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,19998848 0,22124748 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,20480368 0,22646561 ! gliogenesis GO:0042063 71 38 0,000 0,20480368 0,22635679 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,20480368 0,22624807 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,20480368 0,22613945 ! phagocytosis GO:0006909 60 38 0,000 0,20480368 0,22603094 ! maintenance of location in cell GO:0051651 69 38 0,000 0,20480368 0,22592253 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,20959018 0,23109176 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,20959018 0,23098103 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,20959018 0,23087041 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,20959018 0,23075989 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,20959018 0,23064948 ! chromatin remodeling GO:0006338 68 39 0,000 0,20959018 0,23053917 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,20959018 0,23042897 ! JNK cascade GO:0007254 54 39 0,000 0,20959018 0,23031888 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,21434813 0,23543491 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,21434813 0,23532253 ! regulation of tube size GO:0035150 60 40 0,000 0,21434813 0,23521026 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,21434813 0,2350981 ! peptide metabolic process GO:0006518 56 40 0,000 0,21434813 0,23498604 ! inner ear development GO:0048839 57 40 0,000 0,21434813 0,23487409 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,21434813 0,23476224 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! positive regulation of protein transport GO:0051222 55 40 0,000 0,21434813 0,2346505 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,21907772 0,23971397 ! glucose transport GO:0015758 52 41 0,000 0,21907772 0,23959998 ! endosome transport GO:0016197 71 41 0,000 0,21907772 0,2394861 ! striated muscle contraction GO:0006941 62 41 0,000 0,21907772 0,23937233 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,21907772 0,23925867 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,21907772 0,23914512 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,2237791 0,24416126 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,2237791 0,24404549 ! hexose transport GO:0008645 54 42 0,000 0,2237791 0,24392983 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,2237791 0,24381428 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,2237791 0,24369884 ! excretion GO:0007588 63 42 0,000 0,2237791 0,2435835 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,2237791 0,24346828 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,2237791 0,24335316 ! positive regulation of binding GO:0051099 59 43 0,000 0,22845245 0,24831788 ! leukocyte migration GO:0050900 60 43 0,000 0,22845245 0,24820059 ! neuromuscular process GO:0050905 79 43 0,000 0,22845245 0,2480834 ! tRNA processing GO:0008033 49 43 0,000 0,22845245 0,24796632 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,22845245 0,24784936 ! response to insulin stimulus GO:0032868 63 43 0,000 0,22845245 0,2477325 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,23309793 0,25265091 ! glycolysis GO:0006096 53 44 0,000 0,23309793 0,25253191 ! regulation of ion transport GO:0043269 57 44 0,000 0,23309793 0,25241301 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,23309793 0,25229423 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,23309793 0,25217556 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,23309793 0,252057 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,23309793 0,25193855 ! RNA catabolic process GO:0006401 64 45 0,000 0,2377157 0,25680889 ! positive regulation of defense response GO:0031349 59 45 0,000 0,2377157 0,25668832 ! regulation of translational initiation GO:0006446 64 45 0,000 0,2377157 0,25656786 ! cell recognition GO:0008037 58 45 0,000 0,2377157 0,25644752 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,24230593 0,26127691 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,24230593 0,26115447 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,24230593 0,26103215 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,24230593 0,26090995 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,24686879 0,26569874 ! viral infectious cycle GO:0019058 71 47 0,000 0,24686879 0,26557447 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,24686879 0,26545031 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,24686879 0,26532626 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,24686879 0,26520234 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,24686879 0,26507853 ! chloride transport GO:0006821 67 48 0,000 0,25140442 0,26982276 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,25140442 0,26969691 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,25140442 0,26957117 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,25140442 0,26944556 ! gastrulation GO:0007369 73 48 0,000 0,25140442 0,26932006 ! heart morphogenesis GO:0003007 65 48 0,000 0,25140442 0,26919468 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,25140442 0,26906941 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,25140442 0,26894426 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,25140442 0,26881923 ! regulation of endocytosis GO:0030100 63 48 0,000 0,25140442 0,26869431 ! nuclear export GO:0051168 69 48 0,000 0,25140442 0,26856951 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,25140442 0,26844483 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,255913 0,2731322 ! sensory perception of smell GO:0007608 61 49 0,000 0,255913 0,27300552 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,255913 0,27287895 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,255913 0,2727525 ! RNA elongation GO:0006354 62 49 0,000 0,255913 0,27262617 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,255913 0,27249995 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,255913 0,27237385 ! cartilage development GO:0051216 70 49 0,000 0,255913 0,27224787 ! maintenance of location GO:0051235 84 49 0,000 0,255913 0,272122 ! regulation of actin filament length GO:0030832 72 50 0,000 0,26039468 0,27675959 ! membrane fusion GO:0006944 80 50 0,000 0,26039468 0,27663176 ! lipid modification GO:0030258 73 50 0,000 0,26039468 0,27650404 ! proton transport GO:0015992 75 50 0,000 0,26039468 0,27637645 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,26039468 0,27624897 ! positive regulation of secretion GO:0051047 71 51 0,000 0,26484962 0,28084561 ! hydrogen transport GO:0006818 77 51 0,000 0,26484962 0,28071619 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,26484962 0,28058688 ! adult behavior GO:0030534 80 51 0,000 0,26484962 0,2804577 ! transition metal ion transport GO:0000041 74 52 0,000 0,26927798 0,28501581 ! regulation of cellular component size GO:0032535 74 52 0,000 0,26927798 0,28488471 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,26927798 0,28475373 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,27367992 0,28927565 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,27367992 0,28914278 ! single fertilization GO:0007338 59 53 0,000 0,27367992 0,28901002 ! amino acid transport GO:0006865 84 54 0,000 0,2780556 0,29349604 ! glucose catabolic process GO:0006007 66 54 0,000 0,2780556 0,29336141 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,2780556 0,2932269 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,2780556 0,29309252 ! exocytosis GO:0006887 74 55 0,000 0,28240516 0,29754094 ! mesoderm development GO:0007498 76 55 0,000 0,28240516 0,2974047 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,28240516 0,29726859 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,28240516 0,2971326 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,28672876 0,30154374 ! carbohydrate transport GO:0008643 74 57 0,000 0,29102656 0,30592372 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,29102656 0,30578396 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,29102656 0,30564434 ! camera-type eye development GO:0043010 88 57 0,000 0,29102656 0,30550484 ! viral reproductive process GO:0022415 87 58 0,000 0,29529871 0,3098481 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,29529871 0,30970681 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,29529871 0,30956565 ! activation of MAPK activity GO:0000187 84 59 0,000 0,29954536 0,31387441 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,29954536 0,31373148 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,30376666 0,31800789 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,30376666 0,31786321 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,30376666 0,31771866 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,30376666 0,31757424 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,30376666 0,31742995 ! regulation of heart contraction GO:0008016 91 60 0,000 0,30376666 0,3172858 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,30376666 0,31714177 ! fertilization GO:0009566 68 60 0,000 0,30376666 0,31699788 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,30796277 0,321231 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,30796277 0,32108539 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,31213382 0,32528672 ! neurotransmitter transport GO:0006836 81 62 0,000 0,31213382 0,3251394 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,31213382 0,32499221 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,31213382 0,32484515 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,31627997 0,32901128 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,31627997 0,32886254 ! viral reproduction GO:0016032 92 63 0,000 0,31627997 0,32871393 ! appendage morphogenesis GO:0035107 93 64 0,000 0,32040137 0,33284695 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,32040137 0,33269668 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,32040137 0,33254655 ! hexose catabolic process GO:0019320 82 64 0,000 0,32040137 0,33239655 ! appendage development GO:0048736 94 65 0,000 0,32449816 0,33649493 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,32449816 0,33634329 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,32449816 0,33619178 ! activation of immune response GO:0002253 83 65 0,000 0,32449816 0,33604041 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,32857048 0,34010446 ! antigen processing and presentation GO:0019882 96 66 0,000 0,32857048 0,33995146 ! regulation of immune effector process GO:0002697 101 66 0,000 0,32857048 0,33979861 ! acute inflammatory response GO:0002526 92 68 0,000 0,33664232 0,34798982 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,33664232 0,34783349 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,33664232 0,3476773 ! inorganic anion transport GO:0015698 93 68 0,000 0,33664232 0,34752125 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,34064212 0,35149255 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,34461804 0,35543564 ! eye development GO:0001654 111 70 0,000 0,34461804 0,35527633 ! amine transport GO:0015837 101 70 0,000 0,34461804 0,35511715 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,34461804 0,35495812 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,3485702 0,35886816 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,3485702 0,35870759 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,3485702 0,35854717 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,35249876 0,36242608 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,35640385 0,36627742 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,36028561 0,37010135 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,36028561 0,36993612 ! blood coagulation GO:0007596 116 75 0,000 0,36414419 0,3737312 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,36414419 0,37356451 ! amine biosynthetic process GO:0009309 97 76 0,000 0,3679797 0,37733095 ! tRNA metabolic process GO:0006399 95 76 0,000 0,3679797 0,3771628 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,3717923 0,3809008 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,3717923 0,38073121 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,3717923 0,38056177 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,3717923 0,38039248 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,37558212 0,3840991 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,37558212 0,38392839 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,3793493 0,38760701 ! cellular respiration GO:0045333 107 79 0,000 0,3793493 0,38743489 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,3793493 0,38726293 ! regulation of lyase activity GO:0051339 133 79 0,000 0,3793493 0,38709112 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,3793493 0,38691946 ! chromatin assembly GO:0031497 102 80 0,000 0,38309396 0,39056565 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,38309396 0,3903926 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,38309396 0,39021971 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,38681624 0,39383681 ! hemostasis GO:0007599 125 81 0,000 0,38681624 0,39366254 ! mRNA transport GO:0051028 121 81 0,000 0,38681624 0,39348843 ! regulation of neurological system process GO:0031644 122 81 0,000 0,38681624 0,39331448 ! vitamin metabolic process GO:0006766 103 81 0,000 0,38681624 0,39314067 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,38681624 0,39296703 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,39419419 0,40028549 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,39419419 0,40010884 ! regulation of defense response GO:0031347 117 84 0,000 0,39785013 0,4036415 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,39785013 0,40346353 ! sterol metabolic process GO:0016125 120 84 0,000 0,39785013 0,40328572 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,40148421 0,40679017 ! rRNA metabolic process GO:0016072 107 85 0,000 0,40148421 0,40661104 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,40148421 0,40643208 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,40509656 0,40990853 ! nucleosome organization GO:0034728 114 87 0,000 0,40868732 0,41336009 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,40868732 0,41317839 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,40868732 0,41299686 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,41225661 0,41642082 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,41225661 0,41623802 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,41225661 0,41605538 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,41580457 0,41945197 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,41580457 0,41926808 ! RNA localization GO:0006403 135 91 0,000 0,42283695 0,42617221 ! ATP metabolic process GO:0046034 137 91 0,000 0,42283695 0,42598554 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,42632163 0,42930812 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,42632163 0,42912024 ! positive regulation of immune response GO:0050778 121 92 0,000 0,42632163 0,42893253 ! sulfur metabolic process GO:0006790 118 92 0,000 0,42632163 0,42874497 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,42978547 0,43203959 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,42978547 0,43185085 ! electron transport chain GO:0022900 123 94 0,000 0,4332286 0,43512043 ! carboxylic acid transport GO:0046942 147 95 0,000 0,43665113 0,43836648 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,44005319 0,44158916 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,4434349 0,44478861 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,45013775 0,4513151 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,45013775 0,45111845 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,45345913 0,45424913 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,45345913 0,45405138 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,45345913 0,45385379 ! divalent metal ion transport GO:0070838 171 100 0,000 0,45345913 0,45365638 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,45345913 0,45345913