pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6556-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of epithelial cell proliferation GO:0050678 122 45 4,000 4,801E-07 1,173E-03 ! activation of MAPKKK activity GO:0000185 12 6 2,000 7,831E-07 9,566E-04 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 3,000 1,331E-06 1,084E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 2,182E-06 1,332E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 3,264E-06 1,595E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 2,000 6,38E-06 2,598E-03 ! androgen receptor signaling pathway GO:0030521 81 37 3,000 7,992E-06 2,789E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 1,742E-05 5,319E-03 ! activation of MAPKK activity GO:0000186 43 17 2,000 2,59E-05 7,03E-03 ! response to UV GO:0009411 120 55 3,000 3,935E-05 9,613E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 8,077E-05 0,01793734 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 8,586E-05 0,01748026 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 9,611E-05 0,01806178 ! negative regulation of kinase activity GO:0033673 145 70 3,000 1,017E-04 0,01774115 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,075E-04 0,01750064 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,161E-04 0,0177212 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 1,161E-04 0,01667878 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 1,161E-04 0,01575218 ! microvillus organization GO:0032528 8 5 1,000 1,161E-04 0,01492312 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 1,000 1,161E-04 0,01417696 ! sister chromatid cohesion GO:0007062 15 5 1,000 1,161E-04 0,01350187 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 1,161E-04 0,01288815 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 1,161E-04 0,01232779 ! protein insertion into membrane GO:0051205 17 5 1,000 1,161E-04 0,01181413 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 1,214E-04 0,01186152 ! negative regulation of transferase activity GO:0051348 155 74 3,000 1,262E-04 0,01186202 ! lymphocyte differentiation GO:0030098 193 76 3,000 1,4E-04 0,01266942 ! protein oligomerization GO:0051259 149 79 3,000 1,627E-04 0,01419439 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 1,653E-04 0,01392531 ! activation of protein kinase activity GO:0032147 170 80 3,000 1,708E-04 0,01390858 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 1,737E-04 0,01368878 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 1,737E-04 0,01326101 ! regulation of helicase activity GO:0051095 16 7 1,000 2,426E-04 0,01796234 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 2,426E-04 0,01743404 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 2,426E-04 0,01693592 ! mRNA stabilization GO:0048255 18 7 1,000 2,426E-04 0,01646548 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 2,426E-04 0,01602047 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 2,426E-04 0,01559888 ! B cell lineage commitment GO:0002326 21 7 1,000 2,426E-04 0,01519891 ! T cell lineage commitment GO:0002360 16 7 1,000 2,426E-04 0,01481893 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 3,047E-04 0,01815382 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 3,228E-04 0,01877539 ! male meiosis GO:0007140 9 8 1,000 3,228E-04 0,01833876 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 3,228E-04 0,01792197 ! succinate metabolic process GO:0006105 17 8 1,000 3,228E-04 0,0175237 ! T-helper 1 type immune response GO:0042088 12 8 1,000 3,228E-04 0,01714275 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 3,228E-04 0,01677801 ! ER overload response GO:0006983 13 8 1,000 3,228E-04 0,01642847 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 3,228E-04 0,01609319 ! regulation of vascular permeability GO:0043114 12 8 1,000 3,228E-04 0,01577133 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 3,228E-04 0,01546209 ! response to tumor cell GO:0002347 16 8 1,000 3,228E-04 0,01516474 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 3,228E-04 0,01487861 ! leukocyte differentiation GO:0002521 232 98 3,000 3,72E-04 0,01682939 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 3,72E-04 0,0165234 ! mesenchymal cell development GO:0014031 94 41 2,000 3,823E-04 0,01667919 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of intracellular protein transport GO:0033157 86 42 2,000 4,107E-04 0,01760301 ! T cell differentiation GO:0030217 93 42 2,000 4,107E-04 0,01729951 ! induction of positive chemotaxis GO:0050930 17 9 1,000 4,141E-04 0,01714564 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 5,039E-04 0,02051609 ! B cell differentiation GO:0030183 124 45 2,000 5,039E-04 0,02017976 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 5,164E-04 0,02034919 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 5,164E-04 0,02002619 ! lung alveolus development GO:0048286 26 10 1,000 5,164E-04 0,01971328 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 5,164E-04 0,01941 ! phosphagen metabolic process GO:0006599 17 10 1,000 5,164E-04 0,01911591 GO:0006600|creatine metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 5,164E-04 0,0188306 ! motor axon guidance GO:0008045 22 10 1,000 5,164E-04 0,01855368 ! regulation of bone resorption GO:0045124 25 10 1,000 5,164E-04 0,01828478 ! detection of calcium ion GO:0005513 24 10 1,000 5,164E-04 0,01802357 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 5,164E-04 0,01776972 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 5,377E-04 0,01824389 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 5,377E-04 0,01799397 ! negative regulation of muscle development GO:0048635 27 11 1,000 6,298E-04 0,02079126 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 6,298E-04 0,02051404 ! blood vessel remodeling GO:0001974 30 11 1,000 6,298E-04 0,02024412 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 6,298E-04 0,01998121 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 6,298E-04 0,01972504 ! regulation of intracellular pH GO:0051453 21 11 1,000 6,298E-04 0,01947535 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 6,298E-04 0,01923191 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 6,477E-04 0,01953541 ! protein homooligomerization GO:0051260 84 49 2,000 6,477E-04 0,01929717 ! regulation of B cell proliferation GO:0030888 22 12 1,000 7,54E-04 0,02219419 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 7,54E-04 0,02192997 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 7,54E-04 0,02167197 ! mitotic spindle organization GO:0007052 23 12 1,000 7,54E-04 0,02141997 ! histone acetylation GO:0016573 27 12 1,000 7,54E-04 0,02117377 ! peptidyl-lysine modification GO:0018205 21 12 1,000 7,54E-04 0,02093316 ! regulation of leukocyte migration GO:0002685 29 12 1,000 7,54E-04 0,02069795 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 7,54E-04 0,02046797 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 7,54E-04 0,02024305 ! localization within membrane GO:0051668 26 12 1,000 7,54E-04 0,02002302 ! histone modification GO:0016570 104 52 2,000 7,712E-04 0,02025722 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 2,000 7,712E-04 0,02004172 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 8,154E-04 0,02096819 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! covalent chromatin modification GO:0016569 115 54 2,000 8,612E-04 0,02191559 ! pseudouridine synthesis GO:0001522 19 13 1,000 8,891E-04 0,02239341 ! response to X-ray GO:0010165 28 13 1,000 8,891E-04 0,02216491 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 8,891E-04 0,02194102 ! chromatin silencing GO:0006342 29 13 1,000 8,891E-04 0,02172161 ! regulation of mRNA stability GO:0043488 32 13 1,000 8,891E-04 0,02150654 ! regulation of DNA replication GO:0006275 105 56 2,000 9,576E-04 0,02293657 ! RNA elongation GO:0006354 90 56 2,000 9,576E-04 0,02271388 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 1,008E-03 0,02368607 ! regulation of bone remodeling GO:0046850 143 57 2,000 1,008E-03 0,02346049 ! regulation of intracellular transport GO:0032386 108 57 2,000 1,008E-03 0,02323916 ! regulation of cellular pH GO:0030641 27 14 1,000 1,035E-03 0,02363084 ! response to gamma radiation GO:0010332 30 14 1,000 1,035E-03 0,02341204 ! regulation of RNA stability GO:0043487 33 14 1,000 1,035E-03 0,02319725 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,035E-03 0,02298636 ! positive regulation of cell migration GO:0030335 137 58 2,000 1,061E-03 0,02334455 ! regulation of tissue remodeling GO:0034103 146 58 2,000 1,061E-03 0,02313611 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,192E-03 0,02576065 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 1,192E-03 0,02553468 ! regulation of mRNA processing GO:0050684 26 15 1,000 1,192E-03 0,02531264 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 1,192E-03 0,02509443 ! regulation of exocytosis GO:0017157 26 15 1,000 1,192E-03 0,02487995 ! G1/S transition checkpoint GO:0031575 37 15 1,000 1,192E-03 0,0246691 ! histone deacetylation GO:0016575 24 15 1,000 1,192E-03 0,0244618 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 1,359E-03 0,02766118 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 1,359E-03 0,02743257 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,359E-03 0,02720772 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 1,359E-03 0,02698652 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 1,359E-03 0,02676888 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 1,411E-03 0,02757554 ! positive regulation of cell motion GO:0051272 157 65 2,000 1,476E-03 0,02860902 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 1,000 1,536E-03 0,02955499 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 1,536E-03 0,02932409 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 1,536E-03 0,02909677 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,536E-03 0,02887295 ! negative regulation of cell growth GO:0030308 142 67 2,000 1,61E-03 0,03002873 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 1,725E-03 0,0319182 ! defense response to virus GO:0051607 43 18 1,000 1,725E-03 0,03167821 ! negative regulation of cell size GO:0045792 144 69 2,000 1,752E-03 0,03194782 ! lung development GO:0030324 165 69 2,000 1,752E-03 0,03171117 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 2,000 1,752E-03 0,031478 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 1,923E-03 0,03429429 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 1,923E-03 0,03404578 ! neuromuscular junction development GO:0007528 43 19 1,000 1,923E-03 0,03380085 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 1,923E-03 0,03355942 ! respiratory tube development GO:0030323 171 72 2,000 1,98E-03 0,03430361 ! B cell activation GO:0042113 179 72 2,000 1,98E-03 0,03406203 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 2,132E-03 0,03642417 ! protein amino acid deacetylation GO:0006476 34 20 1,000 2,132E-03 0,03617122 ! protein amino acid acetylation GO:0006473 41 20 1,000 2,132E-03 0,03592176 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 2,132E-03 0,03567572 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 2,132E-03 0,03543303 ! negative regulation of T cell activation GO:0050868 41 20 1,000 2,132E-03 0,03519362 ! regulation of caspase activity GO:0043281 136 74 2,000 2,141E-03 0,03510828 ! respiratory system development GO:0060541 175 74 2,000 2,141E-03 0,03487423 ! lipid phosphorylation GO:0046834 43 21 1,000 2,351E-03 0,03803999 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 2,351E-03 0,03778973 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 2,351E-03 0,03754273 ! positive regulation of osteoblast differentiation GO:0045669 52 21 1,000 2,351E-03 0,03729895 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 2,351E-03 0,03705831 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 2,398E-03 0,03755858 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 2,581E-03 0,04015472 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 2,581E-03 0,03990058 ! cellular response to starvation GO:0009267 37 22 1,000 2,581E-03 0,03964963 ! cell aging GO:0007569 48 22 1,000 2,581E-03 0,03940182 ! positive regulation of locomotion GO:0040017 44 22 1,000 2,581E-03 0,03915709 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 1,000 2,581E-03 0,03891538 ! detection of chemical stimulus GO:0009593 42 22 1,000 2,581E-03 0,03867663 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 2,581E-03 0,0384408 ! positive regulation of B cell activation GO:0050871 42 22 1,000 2,581E-03 0,03820783 ! meiosis GO:0007126 143 81 2,000 2,77E-03 0,04076089 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 2,000 2,77E-03 0,04051681 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 2,77E-03 0,04027564 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 2,000 2,77E-03 0,04003732 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 2,82E-03 0,04052494 ! regulation of chemotaxis GO:0050920 45 23 1,000 2,82E-03 0,04028795 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 2,82E-03 0,04005372 ! meiotic cell cycle GO:0051321 144 82 2,000 2,868E-03 0,0404961 ! regulation of peptidase activity GO:0052547 150 82 2,000 2,868E-03 0,04026336 ! response to oxygen levels GO:0070482 183 83 2,000 2,968E-03 0,04143147 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 2,968E-03 0,04119606 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 3,069E-03 0,0423656 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 3,069E-03 0,04212759 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 3,069E-03 0,04189224 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 3,069E-03 0,04165951 ! T cell activation GO:0042110 189 84 2,000 3,07E-03 0,04143861 ! negative regulation of growth GO:0045926 168 85 2,000 3,175E-03 0,04261267 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 3,175E-03 0,04237982 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 3,329E-03 0,04419855 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 3,329E-03 0,04395964 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 3,329E-03 0,0437233 ! vasculogenesis GO:0001570 49 25 1,000 3,329E-03 0,04348948 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 3,329E-03 0,04325815 ! negative regulation of DNA replication GO:0008156 45 25 1,000 3,329E-03 0,04302927 ! regulation of behavior GO:0050795 48 25 1,000 3,329E-03 0,0428028 ! protein tetramerization GO:0051262 57 25 1,000 3,329E-03 0,04257871 ! regulation of protein transport GO:0051223 165 87 2,000 3,39E-03 0,04313327 GO:0070201|regulation of establishment of protein localization, ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 3,598E-03 0,0455468 ! myelination GO:0042552 50 26 1,000 3,598E-03 0,04531203 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 3,598E-03 0,04507966 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 3,598E-03 0,04484966 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of cell development GO:0010721 83 26 1,000 3,598E-03 0,044622 GO:0050768|negative regulation of neurogenesis, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 3,598E-03 0,04439663 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 3,598E-03 0,04417353 ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 3,598E-03 0,04395267 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 3,877E-03 0,04712707 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 3,877E-03 0,04689377 ! mitochondrial membrane organization GO:0007006 60 27 1,000 3,877E-03 0,04666277 ! response to starvation GO:0042594 47 27 1,000 3,877E-03 0,04643403 ! cellular response to nutrient levels GO:0031669 45 27 1,000 3,877E-03 0,04620752 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 3,877E-03 0,04598321 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 4,166E-03 0,04917096 ! protein amino acid acylation GO:0043543 59 28 1,000 4,166E-03 0,04893456 ! base-excision repair GO:0006284 41 28 1,000 4,166E-03 0,04870042 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 4,166E-03 0,04846851 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 4,465E-03 0,05169622 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 4,465E-03 0,05145237 ! somitogenesis GO:0001756 52 29 1,000 4,465E-03 0,05121081 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 4,6E-03 0,05251163 ! transcription initiation GO:0006352 171 97 2,000 4,6E-03 0,05226739 ! regulation of protein localization GO:0032880 188 97 2,000 4,6E-03 0,05202541 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 4,773E-03 0,05373696 ! neurotransmitter secretion GO:0007269 55 30 1,000 4,773E-03 0,05349046 ! tissue homeostasis GO:0001894 50 30 1,000 4,773E-03 0,05324621 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 1,000 4,773E-03 0,05300418 ! skeletal muscle tissue development GO:0007519 223 100 2,000 5,007E-03 0,0553532 GO:0060538|skeletal muscle organ development, ! ensheathment of neurons GO:0007272 64 31 1,000 5,091E-03 0,05602374 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 5,091E-03 0,05577252 ! response to heat GO:0009408 54 31 1,000 5,091E-03 0,05552353 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 5,418E-03 0,05883018 ! spindle organization GO:0007051 50 32 1,000 5,418E-03 0,05856986 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 5,418E-03 0,05831185 ! peripheral nervous system development GO:0007422 68 32 1,000 5,418E-03 0,05805609 ! positive regulation of catabolic process GO:0009896 72 32 1,000 5,418E-03 0,05780257 ! gene silencing GO:0016458 71 32 1,000 5,418E-03 0,05755126 ! regulation of pH GO:0006885 56 33 1,000 5,755E-03 0,06086281 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 5,755E-03 0,06060047 ! response to ionizing radiation GO:0010212 74 33 1,000 5,755E-03 0,06034039 ! negative regulation of protein transport GO:0051224 74 33 1,000 5,755E-03 0,06008252 ! inner ear morphogenesis GO:0042472 51 34 1,000 6,101E-03 0,06342412 ! DNA damage checkpoint GO:0000077 78 35 1,000 6,456E-03 0,06683347 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 6,456E-03 0,06655147 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 6,456E-03 0,06627185 ! calcium-mediated signaling GO:0019722 67 35 1,000 6,456E-03 0,06599456 ! regulation of muscle development GO:0048634 82 36 1,000 6,821E-03 0,06943017 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 6,821E-03 0,06914208 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 6,821E-03 0,06885637 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 7,194E-03 0,07232976 ! tissue remodeling GO:0048771 78 37 1,000 7,194E-03 0,07203333 ! negative regulation of cell activation GO:0050866 69 37 1,000 7,194E-03 0,07173931 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 7,577E-03 0,07524882 ! DNA integrity checkpoint GO:0031570 82 38 1,000 7,577E-03 0,07494417 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 7,577E-03 0,07464197 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 7,969E-03 0,078186 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 7,969E-03 0,07787326 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 93 40 1,000 8,37E-03 0,08146329 ! regulation of action potential in neuron GO:0019228 80 40 1,000 8,37E-03 0,08114002 ! cellular amide metabolic process GO:0043603 73 41 1,000 8,779E-03 0,08477456 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 8,779E-03 0,08444081 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 8,779E-03 0,08410967 ! RNA modification GO:0009451 64 41 1,000 8,779E-03 0,08378111 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 9,198E-03 0,08743266 ! ear morphogenesis GO:0042471 64 42 1,000 9,198E-03 0,08709378 ! regulation of T cell differentiation GO:0045580 78 42 1,000 9,198E-03 0,08675751 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 9,625E-03 0,09043776 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 9,625E-03 0,09009125 ! regulation of T cell proliferation GO:0042129 80 43 1,000 9,625E-03 0,08974739 ! segmentation GO:0035282 78 43 1,000 9,625E-03 0,08940615 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 0,01006086 0,09310105 ! double-strand break repair GO:0006302 85 44 1,000 0,01006086 0,09274972 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,01095845 0,10064467 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,01095845 0,10026772 ! response to insulin stimulus GO:0032868 98 47 1,000 0,01142002 0,1041012 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,01189004 0,10798282 ! mitochondrial transport GO:0006839 94 48 1,000 0,01189004 0,10758288 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,01189004 0,1071859 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,01189004 0,10679183 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,01189004 0,10640065 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,01189004 0,10601233 ! response to calcium ion GO:0051592 94 49 1,000 0,01236844 0,10987673 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,01236844 0,10947863 ! regulation of action potential GO:0001508 102 50 1,000 0,01285515 0,11337596 ! activation of caspase activity GO:0006919 95 50 1,000 0,01285515 0,11296813 ! regulation of ossification GO:0030278 123 50 1,000 0,01285515 0,11256323 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,01285515 0,11216122 ! response to temperature stimulus GO:0009266 84 51 1,000 0,01335012 0,11606528 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,01335012 0,1156537 ! positive regulation of binding GO:0051099 88 52 1,000 0,01385328 0,11958855 ! positive regulation of growth GO:0045927 96 53 1,000 0,01436457 0,12356564 ! inner ear development GO:0048839 89 53 1,000 0,01436457 0,12313208 ! chromatin remodeling GO:0006338 122 53 1,000 0,01436457 0,12270155 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,01436457 0,12227401 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01436457 0,12184945 ! synapse organization GO:0050808 102 53 1,000 0,01436457 0,12142783 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,01488393 0,12538428 ! regulation of translational initiation GO:0006446 87 54 1,000 0,01488393 0,1249534 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,01488393 0,12452548 GO:0010863|positive regulation of phospholipase C activity, ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,01488393 0,12410048 ! regulation of cell shape GO:0008360 142 54 1,000 0,01488393 0,12367837 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,0154113 0,12762646 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,0154113 0,12719529 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,01594662 0,13117035 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,01594662 0,13073018 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,01648983 0,1347313 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,01648983 0,13428219 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,01648983 0,13383607 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,01648983 0,13339291 ! aging GO:0007568 112 58 1,000 0,01704087 0,13739555 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,01704087 0,13694359 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01704537 0,13653064 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01704537 0,13608446 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01704537 0,13564119 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01704537 0,1352008 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01704537 0,13476325 ! neuron fate determination GO:0048664 7 5 0,000 0,01704537 0,13432853 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01704537 0,13389661 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01704537 0,13346745 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01704537 0,13304104 ! polyol transport GO:0015791 12 5 0,000 0,01704537 0,13261734 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01704537 0,13219633 ! response to superoxide GO:0000303 10 5 0,000 0,01704537 0,13177799 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01704537 0,13136229 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01704537 0,1309492 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01704537 0,1305387 ! female meiosis GO:0007143 10 5 0,000 0,01704537 0,13013077 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01704537 0,12972537 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01704537 0,1293225 ! hypothalamus development GO:0021854 9 5 0,000 0,01704537 0,12892212 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01704537 0,12852421 ! cobalt ion transport GO:0006824 11 5 0,000 0,01704537 0,12812875 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01704537 0,12773572 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01704537 0,12734509 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01704537 0,12695684 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01704537 0,12657096 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01704537 0,12618741 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01704537 0,12580618 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01704537 0,12542724 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01704537 0,12505059 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01704537 0,12467618 ! transposition GO:0032196 9 5 0,000 0,01704537 0,12430401 ! negative chemotaxis GO:0050919 16 5 0,000 0,01704537 0,12393406 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01704537 0,12356631 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01704537 0,12320072 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01704537 0,1228373 ! behavioral response to pain GO:0048266 10 5 0,000 0,01704537 0,12247601 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01704537 0,12211685 ! Notch receptor processing GO:0007220 11 5 0,000 0,01704537 0,12175978 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01704537 0,1214048 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01704537 0,12105188 ! micturition GO:0060073 9 5 0,000 0,01704537 0,120701 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01704537 0,12035215 ! copulation GO:0007620 9 5 0,000 0,01704537 0,12000532 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01704537 0,11966047 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01704537 0,11931761 ! bioluminescence GO:0008218 9 5 0,000 0,01704537 0,1189767 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01704537 0,11863774 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01704537 0,1183007 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01704537 0,11796557 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01704537 0,11763233 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01704537 0,11730097 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01704537 0,11697147 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01704537 0,11664382 ! grooming behavior GO:0007625 6 5 0,000 0,01704537 0,116318 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01704537 0,115994 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01704537 0,11567179 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01704537 0,11535137 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01704537 0,11503272 ! response to protozoan GO:0001562 13 5 0,000 0,01704537 0,11471583 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,01704537 0,11440067 ! lymph vessel development GO:0001945 10 5 0,000 0,01704537 0,11408725 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01704537 0,11377553 ! endochondral ossification GO:0001958 17 5 0,000 0,01704537 0,11346552 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01704537 0,11315719 ! single strand break repair GO:0000012 8 5 0,000 0,01704537 0,11285053 ! parathyroid gland development GO:0060017 14 5 0,000 0,01704537 0,11254553 ! anagen GO:0042640 7 5 0,000 0,01704537 0,11224217 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01704537 0,11194044 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01704537 0,11164034 ! cytokine secretion GO:0050663 15 5 0,000 0,01704537 0,11134183 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01704537 0,11104492 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01704537 0,11074959 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01704537 0,11045582 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01704537 0,11016361 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01704537 0,10987294 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01704537 0,1095838 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01704537 0,10929618 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01704537 0,10901007 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01704537 0,10872544 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01704537 0,1084423 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01704537 0,10816064 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01704537 0,10788043 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01704537 0,10760167 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01704537 0,10732434 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01704537 0,10704844 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01704537 0,10677396 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01704537 0,10650088 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01704537 0,1062292 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01704537 0,10595889 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01704537 0,10568996 ! polyol catabolic process GO:0046174 9 5 0,000 0,01704537 0,10542239 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01704537 0,10515617 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01704537 0,1048913 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01704537 0,10462775 ! muscle cell migration GO:0014812 8 5 0,000 0,01704537 0,10436553 ! mitochondrial fission GO:0000266 8 5 0,000 0,01704537 0,10410461 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01704537 0,103845 ! mRNA transcription GO:0009299 10 5 0,000 0,01704537 0,10358668 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01704537 0,10332964 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01704537 0,10307387 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01704537 0,10281937 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01704537 0,10256612 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01704537 0,10231412 ! monocyte activation GO:0042117 10 5 0,000 0,01704537 0,10206335 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01704537 0,1018138 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01704537 0,10156548 ! response to food GO:0032094 6 5 0,000 0,01704537 0,10131836 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01704537 0,10107244 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01704537 0,10082771 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01704537 0,10058417 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01704537 0,1003418 ! forebrain neuron development GO:0021884 13 5 0,000 0,01704537 0,10010059 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01704537 0,09986054 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01704537 0,09962164 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01704537 0,09938388 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01704537 0,09914725 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01704537 0,09891175 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01704537 0,09867736 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01704537 0,09844408 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01704537 0,0982119 ! lipid glycosylation GO:0030259 7 5 0,000 0,01704537 0,09798081 ! nucleobase transport GO:0015851 6 5 0,000 0,01704537 0,09775081 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01704537 0,09752189 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01704537 0,09729403 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01704537 0,09706724 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01704537 0,0968415 ! basic amino acid transport GO:0015802 12 5 0,000 0,01704537 0,09661681 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01704537 0,09639316 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01704537 0,09617054 ! actin nucleation GO:0045010 11 5 0,000 0,01704537 0,09594895 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01704537 0,09572838 ! depurination GO:0045007 5 5 0,000 0,01704537 0,09550882 ! depyrimidination GO:0045008 10 5 0,000 0,01704537 0,09529026 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01704537 0,09507271 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01704537 0,09485614 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01704537 0,09464056 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01704537 0,09442595 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01704537 0,09421232 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01704537 0,09399965 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01704537 0,09378794 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01704537 0,09357718 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01704537 0,09336737 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01704537 0,09315849 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01704537 0,09295055 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01704537 0,09274353 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01704537 0,09253743 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01704537 0,09233225 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01704537 0,09212798 ! response to arsenic GO:0046685 11 5 0,000 0,01704537 0,0919246 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01704537 0,09172213 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01704537 0,09152054 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01704537 0,09131984 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01704537 0,09112001 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01704537 0,09092106 ! response to mercury ion GO:0046689 8 5 0,000 0,01704537 0,09072297 ! response to cadmium ion GO:0046686 7 5 0,000 0,01704537 0,09052575 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01704537 0,09032938 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01704537 0,09013386 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01704537 0,08993919 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01704537 0,08974536 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01704537 0,08955235 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01704537 0,08936018 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01704537 0,08916883 ! decidualization GO:0046697 11 5 0,000 0,01704537 0,0889783 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01704537 0,08878858 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01704537 0,08859967 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01704537 0,08841156 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01704537 0,08822425 ! embryonic cleavage GO:0040016 6 5 0,000 0,01704537 0,08803773 ! peroxisome fission GO:0016559 5 5 0,000 0,01704537 0,08785199 ! histone demethylation GO:0016577 13 5 0,000 0,01704537 0,08766704 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01704537 0,08748287 ! mitotic recombination GO:0006312 9 5 0,000 0,01704537 0,08729947 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01704537 0,08711683 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01704537 0,08693496 ! metaphase plate congression GO:0051310 7 5 0,000 0,01704537 0,08675384 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01704537 0,08657348 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01704537 0,08639387 ! enteric nervous system development GO:0048484 8 5 0,000 0,01704537 0,086215 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01704537 0,08603687 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01704537 0,08585947 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01704537 0,08568281 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01704537 0,08550687 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01704537 0,08533165 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01704537 0,08515715 ! B cell homeostasis GO:0001782 13 5 0,000 0,01704537 0,08498336 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01704537 0,08481027 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01704537 0,0846379 ! metaphase GO:0051323 11 5 0,000 0,01704537 0,08446622 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01704537 0,08429523 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01704537 0,08412494 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01704537 0,08395533 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01704537 0,08378641 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01704537 0,08361816 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01704537 0,08345059 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01704537 0,08328369 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01704537 0,08311746 ! response to redox state GO:0051775 6 5 0,000 0,01704537 0,08295188 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01704537 0,08278697 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01704537 0,08262271 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01704537 0,0824591 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01704537 0,08229614 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01704537 0,08213382 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01704537 0,08197214 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01704537 0,08181109 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01704537 0,08165068 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01704537 0,08149089 ! striatum development GO:0021756 14 5 0,000 0,01704537 0,08133173 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01704537 0,08117319 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01704537 0,08101526 ! glial cell migration GO:0008347 10 5 0,000 0,01704537 0,08085795 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01704537 0,08070125 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01704537 0,08054515 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01704537 0,08038966 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01704537 0,08023477 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01704537 0,08008047 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01704537 0,07992677 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01704537 0,07977365 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01704537 0,07962112 ! neuroprotection GO:0043526 8 5 0,000 0,01704537 0,07946917 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01704537 0,0793178 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01704537 0,07916701 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01704537 0,07901678 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01704537 0,07886713 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01704537 0,07871804 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01704537 0,07856952 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01704537 0,07842155 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01704537 0,07827414 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01704537 0,07812729 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01704537 0,07798098 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01704537 0,07783522 ! spindle assembly GO:0051225 6 5 0,000 0,01704537 0,07769001 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01704537 0,07754534 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01704537 0,0774012 ! protein palmitoylation GO:0018345 12 5 0,000 0,01704537 0,0772576 ! drug metabolic process GO:0017144 7 5 0,000 0,01704537 0,07711453 ! stem cell division GO:0017145 11 5 0,000 0,01704537 0,07697199 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01704537 0,07682997 ! organ regeneration GO:0031100 7 5 0,000 0,01704537 0,07668848 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01704537 0,07654751 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01704537 0,07640706 ! regulation of neurotransmitter levels GO:0001505 113 60 1,000 0,01816621 0,08128214 ! lipid modification GO:0030258 112 60 1,000 0,01816621 0,08113355 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,01932216 0,08613876 ! tRNA processing GO:0008033 102 62 1,000 0,01932216 0,08598186 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,01932216 0,08582553 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02041971 0,09053601 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02041971 0,090372 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02041971 0,09020858 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02041971 0,09004575 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02041971 0,0898835 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02041971 0,08972184 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02041971 0,08956076 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02041971 0,08940026 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02041971 0,08924033 ! response to oxygen radical GO:0000305 11 6 0,000 0,02041971 0,08908097 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02041971 0,08892218 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02041971 0,08876396 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02041971 0,08860629 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02041971 0,08844919 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02041971 0,08829264 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02041971 0,08813665 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02041971 0,08798121 ! forebrain regionalization GO:0021871 9 6 0,000 0,02041971 0,08782631 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02041971 0,08767196 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02041971 0,08751815 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02041971 0,08736487 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02041971 0,08721214 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02041971 0,08705994 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02041971 0,08690826 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02041971 0,08675712 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02041971 0,0866065 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02041971 0,0864564 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02041971 0,08630682 ! malate metabolic process GO:0006108 13 6 0,000 0,02041971 0,08615776 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02041971 0,08600921 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02041971 0,08586118 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02041971 0,08571365 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02041971 0,08556663 ! protein refolding GO:0042026 15 6 0,000 0,02041971 0,08542011 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02041971 0,08527409 ! opsonization GO:0008228 8 6 0,000 0,02041971 0,08512857 ! mating behavior GO:0007617 7 6 0,000 0,02041971 0,08498355 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02041971 0,08483902 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02041971 0,08469498 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02041971 0,08455143 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02041971 0,08440836 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02041971 0,08426578 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02041971 0,08412368 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02041971 0,08398206 ! toxin metabolic process GO:0009404 11 6 0,000 0,02041971 0,08384091 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02041971 0,08370024 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02041971 0,08356004 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02041971 0,08342031 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,02041971 0,08328104 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02041971 0,08314224 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02041971 0,0830039 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02041971 0,08286602 ! thymic T cell selection GO:0045061 16 6 0,000 0,02041971 0,0827286 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02041971 0,08259163 ! protein lipoylation GO:0009249 10 6 0,000 0,02041971 0,08245511 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02041971 0,08231905 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02041971 0,08218343 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02041971 0,08204826 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02041971 0,08191354 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02041971 0,08177925 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02041971 0,08164541 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02041971 0,081512 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02041971 0,08137903 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02041971 0,08124649 ! hyperosmotic response GO:0006972 10 6 0,000 0,02041971 0,08111438 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02041971 0,0809827 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02041971 0,08085145 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02041971 0,08072062 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02041971 0,08059022 ! urea metabolic process GO:0019627 7 6 0,000 0,02041971 0,08046023 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02041971 0,08033067 ! neutrophil activation GO:0042119 7 6 0,000 0,02041971 0,08020152 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02041971 0,08007278 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02041971 0,07994446 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02041971 0,07981655 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02041971 0,07968905 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02041971 0,07956195 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02041971 0,07943526 ! neuron apoptosis GO:0051402 15 6 0,000 0,02041971 0,07930897 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02041971 0,07918309 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02041971 0,0790576 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02041971 0,07893251 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02041971 0,07880781 ! carnitine transport GO:0015879 10 6 0,000 0,02041971 0,07868351 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02041971 0,0785596 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02041971 0,07843607 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02041971 0,07831294 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02041971 0,07819019 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02041971 0,07806783 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02041971 0,07794585 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02041971 0,07782425 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02041971 0,07770303 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02041971 0,07758218 ! establishment of spindle localization GO:0051293 16 6 0,000 0,02041971 0,07746171 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02041971 0,07734162 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02041971 0,07722189 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,02041971 0,07710254 ! response to UV-C GO:0010225 14 6 0,000 0,02041971 0,07698355 ! astrocyte development GO:0014002 16 6 0,000 0,02041971 0,07686494 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02041971 0,07674668 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02041971 0,07662879 ! interaction with symbiont GO:0051702 14 6 0,000 0,02041971 0,07651126 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02041971 0,07639409 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02041971 0,07627728 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02041971 0,07616083 ! response to copper ion GO:0046688 10 6 0,000 0,02041971 0,07604473 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02041971 0,07592899 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02041971 0,07581359 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02041971 0,07569855 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02041971 0,07558385 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02041971 0,07546951 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02041971 0,0753555 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02041971 0,07524185 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02041971 0,07512853 ! hair follicle maturation GO:0048820 8 6 0,000 0,02041971 0,07501555 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02041971 0,07490292 ! Schwann cell development GO:0014044 15 6 0,000 0,02041971 0,07479062 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02041971 0,07467866 ! response to pheromone GO:0019236 6 6 0,000 0,02041971 0,07456703 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02041971 0,07445574 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02041971 0,07434477 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02041971 0,07423414 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02041971 0,07412384 ! subpallium development GO:0021544 15 6 0,000 0,02041971 0,07401386 ! neural tube patterning GO:0021532 8 6 0,000 0,02041971 0,07390421 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02041971 0,07379489 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02041971 0,07368588 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02041971 0,0735772 ! G2 phase GO:0051319 16 6 0,000 0,02041971 0,07346884 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02041971 0,0733608 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02041971 0,07325307 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02041971 0,07314567 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02041971 0,07303857 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02041971 0,07293179 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02041971 0,07282532 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02041971 0,07271916 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02041971 0,07261331 ! receptor internalization GO:0031623 11 6 0,000 0,02041971 0,07250777 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,02041971 0,07240253 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,02041971 0,0722976 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02041971 0,07219297 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02041971 0,07208865 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02041971 0,07198462 ! protein deubiquitination GO:0016579 16 6 0,000 0,02041971 0,0718809 ! protein destabilization GO:0031648 9 6 0,000 0,02041971 0,07177747 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02041971 0,07167434 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02041971 0,07157151 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02041971 0,07146897 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02041971 0,07136673 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02041971 0,07126478 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02041971 0,07116311 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02041971 0,07106174 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02041971 0,07096066 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02041971 0,07085986 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02041971 0,07075935 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02041971 0,07065913 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02041971 0,07055918 ! neural plate development GO:0001840 9 6 0,000 0,02041971 0,07045952 ! catecholamine transport GO:0051937 9 6 0,000 0,02041971 0,07036015 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02041971 0,07026105 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02041971 0,07016223 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02041971 0,07006368 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02041971 0,06996542 ! maternal placenta development GO:0001893 12 6 0,000 0,02041971 0,06986743 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02041971 0,06976971 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02041971 0,06967227 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02041971 0,0695751 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02041971 0,06947819 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02041971 0,06938156 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02041971 0,0692852 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02041971 0,0691891 GO:0055081|anion homeostasis, ! response to peptide hormone stimulus GO:0043434 129 64 1,000 0,02050826 0,06939292 ! ear development GO:0043583 114 66 1,000 0,02172406 0,07340508 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,02172406 0,07330369 ! activation of MAPK activity GO:0000187 124 67 1,000 0,02234294 0,07528802 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,02234294 0,07518431 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 1,000 0,02234294 0,0750809 ! regulation of lipase activity GO:0060191 137 68 1,000 0,02296908 0,07707894 ! adaptive immune response GO:0002250 126 68 1,000 0,02296908 0,07697321 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 1,000 0,02296908 0,07686777 ! tRNA transcription GO:0009304 17 7 0,000 0,02378255 0,07948122 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02378255 0,07937264 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02378255 0,07926436 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02378255 0,07915637 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02378255 0,07904867 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02378255 0,07894127 ! sleep GO:0030431 16 7 0,000 0,02378255 0,07883416 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02378255 0,07872734 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02378255 0,0786208 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02378255 0,07851456 ! prostate gland development GO:0030850 14 7 0,000 0,02378255 0,0784086 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02378255 0,07830293 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02378255 0,07819754 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02378255 0,07809244 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02378255 0,07798762 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02378255 0,07788308 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02378255 0,07777881 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02378255 0,07767483 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02378255 0,07757113 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02378255 0,0774677 ! glycolipid transport GO:0046836 11 7 0,000 0,02378255 0,07736455 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02378255 0,07726167 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,02378255 0,07715906 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02378255 0,07705673 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02378255 0,07695467 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02378255 0,07685288 ! pericardium development GO:0060039 16 7 0,000 0,02378255 0,07675135 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02378255 0,0766501 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02378255 0,07654911 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02378255 0,07644839 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,02378255 0,07634793 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02378255 0,07624774 ! lipoprotein transport GO:0042953 14 7 0,000 0,02378255 0,0761478 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02378255 0,07604813 ! rhythmic behavior GO:0007622 17 7 0,000 0,02378255 0,07594872 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02378255 0,07584958 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02378255 0,07575068 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02378255 0,07565205 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02378255 0,07555367 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02378255 0,07545555 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02378255 0,07535768 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02378255 0,07526007 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02378255 0,07516271 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02378255 0,0750656 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02378255 0,07496874 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02378255 0,07487213 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02378255 0,07477577 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02378255 0,07467966 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02378255 0,07458379 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02378255 0,07448817 ! spinal cord patterning GO:0021511 14 7 0,000 0,02378255 0,0743928 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02378255 0,07429767 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02378255 0,07420278 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02378255 0,07410813 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02378255 0,07401373 ! adrenal gland development GO:0030325 17 7 0,000 0,02378255 0,07391956 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02378255 0,07382563 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02378255 0,07373195 ! ovulation GO:0030728 10 7 0,000 0,02378255 0,0736385 ! adenohypophysis development GO:0021984 11 7 0,000 0,02378255 0,07354528 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02378255 0,07345231 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02378255 0,07335956 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02378255 0,07326705 ! microtubule nucleation GO:0007020 21 7 0,000 0,02378255 0,07317478 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02378255 0,07308274 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02378255 0,07299092 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02378255 0,07289934 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02378255 0,07280799 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02378255 0,07271686 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02378255 0,07262597 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02378255 0,0725353 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02378255 0,07244486 ! galactose metabolic process GO:0006012 13 7 0,000 0,02378255 0,07235464 ! vesicle fusion GO:0006906 20 7 0,000 0,02378255 0,07226465 ! response to dietary excess GO:0002021 8 7 0,000 0,02378255 0,07217488 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02378255 0,07208533 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02378255 0,071996 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02378255 0,0719069 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02378255 0,07181802 ! organ growth GO:0035265 15 7 0,000 0,02378255 0,07172935 ! nucleoside transport GO:0015858 11 7 0,000 0,02378255 0,07164091 ! nucleoside salvage GO:0043174 11 7 0,000 0,02378255 0,07155268 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02378255 0,07146467 ! male sex determination GO:0030238 15 7 0,000 0,02378255 0,07137687 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02378255 0,07128929 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02378255 0,07120193 ! parturition GO:0007567 16 7 0,000 0,02378255 0,07111478 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02378255 0,07102784 ! rRNA modification GO:0000154 14 7 0,000 0,02378255 0,07094112 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02378255 0,0708546 ! spindle checkpoint GO:0031577 16 7 0,000 0,02378255 0,0707683 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02378255 0,07068221 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02378255 0,07059632 ! monocyte differentiation GO:0030224 16 7 0,000 0,02378255 0,07051065 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02378255 0,07042518 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02378255 0,07033992 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02378255 0,07025487 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02378255 0,07017002 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02378255 0,07008537 ! fibrinolysis GO:0042730 11 7 0,000 0,02378255 0,07000093 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02378255 0,0699167 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02378255 0,06983266 ! eating behavior GO:0042755 8 7 0,000 0,02378255 0,06974883 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02378255 0,0696652 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02378255 0,06958177 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02378255 0,06949853 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02378255 0,0694155 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02378255 0,06933267 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02378255 0,06925003 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02378255 0,06916759 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02378255 0,06908534 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02378255 0,0690033 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02378255 0,06892144 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02378255 0,06883978 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02378255 0,06875831 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02378255 0,06867704 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02378255 0,06859596 ! histone ubiquitination GO:0016574 9 7 0,000 0,02378255 0,06851506 ! regulation of meiosis GO:0040020 12 7 0,000 0,02378255 0,06843436 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02378255 0,06835385 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02378255 0,06827353 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02378255 0,0681934 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02378255 0,06811345 ! transcription termination GO:0006353 14 7 0,000 0,02378255 0,06803369 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02378255 0,06795412 ! anaphase GO:0051322 18 7 0,000 0,02378255 0,06787474 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02378255 0,06779554 ! axonal fasciculation GO:0007413 19 7 0,000 0,02378255 0,06771652 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02378255 0,06763769 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02378255 0,06755904 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02378255 0,06748057 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02378255 0,06740229 ! diuresis GO:0030146 12 7 0,000 0,02378255 0,06732419 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02378255 0,06724627 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02378255 0,06716853 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02378255 0,06709096 ! antibiotic transport GO:0042891 9 7 0,000 0,02378255 0,06701358 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02378255 0,06693638 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02378255 0,06685935 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02378255 0,0667825 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02378255 0,06670583 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02378255 0,06662933 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02378255 0,06655301 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02378255 0,06647686 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02378255 0,06640089 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02378255 0,06632509 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02378255 0,06624946 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02378255 0,066174 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02378255 0,06609872 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02378255 0,06602361 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02378255 0,06594867 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02378255 0,06587389 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02378255 0,06579929 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02378255 0,06572486 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02378255 0,06565059 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02378255 0,0655765 ! muscle adaptation GO:0043500 13 7 0,000 0,02378255 0,06550256 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02378255 0,0654288 ! retina homeostasis GO:0001895 12 7 0,000 0,02378255 0,0653552 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02378255 0,06528177 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02378255 0,0652085 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02378255 0,0651354 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02378255 0,06506246 ! cell cycle checkpoint GO:0000075 145 71 1,000 0,02489045 0,0680172 ! appendage morphogenesis GO:0035107 150 72 1,000 0,02554504 0,06972797 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 151 73 1,000 0,0262066 0,07145394 GO:0060173|limb development, ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,02687508 0,07319491 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02713395 0,07381763 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02713395 0,07373552 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02713395 0,07365359 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02713395 0,07357185 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02713395 0,07349028 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02713395 0,0734089 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02713395 0,07332769 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02713395 0,07324667 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02713395 0,07316582 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02713395 0,07308515 ! meiotic prophase I GO:0007128 14 8 0,000 0,02713395 0,07300466 ! response to zinc ion GO:0010043 12 8 0,000 0,02713395 0,07292435 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02713395 0,07284421 ! oligopeptide transport GO:0006857 16 8 0,000 0,02713395 0,07276425 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02713395 0,07268447 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02713395 0,07260486 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02713395 0,07252542 ! signal peptide processing GO:0006465 12 8 0,000 0,02713395 0,07244616 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02713395 0,07236707 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02713395 0,07228815 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02713395 0,0722094 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02713395 0,07213083 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02713395 0,07205243 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02713395 0,07197419 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02713395 0,07189613 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02713395 0,07181824 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02713395 0,07174051 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02713395 0,07166295 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02713395 0,07158556 ! reflex GO:0060004 17 8 0,000 0,02713395 0,07150834 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02713395 0,07143129 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02713395 0,07135439 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02713395 0,07127767 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02713395 0,07120111 ! pigment granule organization GO:0048753 17 8 0,000 0,02713395 0,07112471 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02713395 0,07104848 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02713395 0,07097241 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02713395 0,07089651 ! histidine catabolic process GO:0006548 10 8 0,000 0,02713395 0,07082076 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02713395 0,07074518 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02713395 0,07066976 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02713395 0,0705945 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02713395 0,0705194 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02713395 0,07044446 ! melanin metabolic process GO:0006582 17 8 0,000 0,02713395 0,07036967 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02713395 0,07029505 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02713395 0,07022059 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02713395 0,07014628 ! macrophage activation GO:0042116 13 8 0,000 0,02713395 0,07007213 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02713395 0,06999813 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02713395 0,0699243 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02713395 0,06985061 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02713395 0,06977709 ! purine salvage GO:0043101 12 8 0,000 0,02713395 0,06970371 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02713395 0,0696305 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02713395 0,06955743 ! osteoblast development GO:0002076 17 8 0,000 0,02713395 0,06948452 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02713395 0,06941176 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02713395 0,06933916 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02713395 0,0692667 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02713395 0,0691944 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02713395 0,06912224 ! response to UV-B GO:0010224 17 8 0,000 0,02713395 0,06905024 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02713395 0,06897839 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02713395 0,06890669 ! intermediate filament organization GO:0045109 12 8 0,000 0,02713395 0,06883513 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02713395 0,06876373 ! cellular extravasation GO:0045123 13 8 0,000 0,02713395 0,06869247 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02713395 0,06862136 ! response to antibiotic GO:0046677 11 8 0,000 0,02713395 0,0685504 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02713395 0,06847958 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02713395 0,06840891 ! DNA topological change GO:0006265 12 8 0,000 0,02713395 0,06833838 ! response to tropane GO:0014073 15 8 0,000 0,02713395 0,06826801 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,02713395 0,06819777 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02713395 0,06812768 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02713395 0,06805773 ! mast cell activation GO:0045576 14 8 0,000 0,02713395 0,06798793 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02713395 0,06791827 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02713395 0,06784875 ! gas homeostasis GO:0033483 14 8 0,000 0,02713395 0,06777938 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02713395 0,06771015 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02713395 0,06764105 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02713395 0,0675721 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02713395 0,06750329 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02713395 0,06743462 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,02713395 0,06736609 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02713395 0,0672977 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02713395 0,06722945 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02713395 0,06716133 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02713395 0,06709335 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02713395 0,06702551 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,02713395 0,06695781 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02713395 0,06689025 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02713395 0,06682282 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02713395 0,06675552 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02713395 0,06668836 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02713395 0,06662134 ! hormone catabolic process GO:0042447 17 8 0,000 0,02713395 0,06655445 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02713395 0,0664877 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02713395 0,06642108 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02713395 0,06635459 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02713395 0,06628823 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02713395 0,06622201 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02713395 0,06615592 ! adult feeding behavior GO:0008343 10 8 0,000 0,02713395 0,06608996 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02713395 0,06602414 ! ATP catabolic process GO:0006200 11 8 0,000 0,02713395 0,06595844 ! blastocyst growth GO:0001832 19 8 0,000 0,02713395 0,06589288 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02713395 0,06582744 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02713395 0,06576214 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02713395 0,06569696 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02713395 0,06563191 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02713395 0,065567 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02713395 0,06550221 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02713395 0,06543754 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02713395 0,06537301 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02713395 0,0653086 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02713395 0,06524432 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02713395 0,06518017 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02713395 0,06511614 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02713395 0,06505224 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02713395 0,06498846 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02713395 0,06492481 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02713395 0,06486128 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02713395 0,06479788 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02713395 0,0647346 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02713395 0,06467145 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,02755043 0,0656001 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,02755043 0,06553622 ! axon guidance GO:0007411 162 75 1,000 0,02755043 0,06547247 ! learning or memory GO:0007611 161 76 1,000 0,02823259 0,06702839 ! neurotransmitter transport GO:0006836 142 77 1,000 0,0289215 0,06859731 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,0289215 0,06853077 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,0289215 0,06846437 ! regulation of catabolic process GO:0009894 173 77 1,000 0,0289215 0,06839809 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,02961712 0,06997545 ! axon extension GO:0048675 16 9 0,000 0,03047393 0,07193025 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,03047393 0,07186082 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03047393 0,07179153 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03047393 0,07172236 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03047393 0,07165333 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03047393 0,07158444 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03047393 0,07151567 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03047393 0,07144704 ! reproductive behavior GO:0019098 22 9 0,000 0,03047393 0,07137854 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03047393 0,07131017 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,03047393 0,07124193 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03047393 0,07117382 ! UTP metabolic process GO:0046051 10 9 0,000 0,03047393 0,07110584 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03047393 0,07103799 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03047393 0,07097027 ! artery development GO:0060840 25 9 0,000 0,03047393 0,07090268 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03047393 0,07083522 ! regulation of glycolysis GO:0006110 20 9 0,000 0,03047393 0,07076788 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03047393 0,07070068 ! equilibrioception GO:0050957 20 9 0,000 0,03047393 0,0706336 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03047393 0,07056665 ! chemosensory behavior GO:0007635 21 9 0,000 0,03047393 0,07049982 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03047393 0,07043312 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,03047393 0,07036655 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03047393 0,07030011 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03047393 0,07023379 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03047393 0,07016759 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03047393 0,07010152 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03047393 0,07003557 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03047393 0,06996975 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03047393 0,06990405 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03047393 0,06983847 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03047393 0,06977302 ! protein targeting to ER GO:0045047 25 9 0,000 0,03047393 0,06970769 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03047393 0,06964248 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03047393 0,0695774 ! T cell selection GO:0045058 27 9 0,000 0,03047393 0,06951243 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03047393 0,06944759 ! glycine catabolic process GO:0006546 15 9 0,000 0,03047393 0,06938286 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03047393 0,06931826 ! endosome organization GO:0007032 20 9 0,000 0,03047393 0,06925378 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03047393 0,06918942 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03047393 0,06912517 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03047393 0,06906105 ! mannose metabolic process GO:0006013 13 9 0,000 0,03047393 0,06899705 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03047393 0,06893316 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03047393 0,06886939 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03047393 0,06880574 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03047393 0,06874221 ! receptor clustering GO:0043113 20 9 0,000 0,03047393 0,06867879 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03047393 0,0686155 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03047393 0,06855231 ! retinol metabolic process GO:0042572 20 9 0,000 0,03047393 0,06848925 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03047393 0,0684263 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03047393 0,06836346 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03047393 0,06830075 ! macrophage differentiation GO:0030225 15 9 0,000 0,03047393 0,06823814 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03047393 0,06817565 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03047393 0,06811328 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03047393 0,06805102 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03047393 0,06798887 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03047393 0,06792684 ! response to amine stimulus GO:0014075 13 9 0,000 0,03047393 0,06786492 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03047393 0,06780311 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03047393 0,06774141 ! erythrocyte development GO:0048821 17 9 0,000 0,03047393 0,06767983 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03047393 0,06761836 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,03047393 0,067557 ! renal water homeostasis GO:0003091 15 9 0,000 0,03047393 0,06749575 ! postreplication repair GO:0006301 25 9 0,000 0,03047393 0,06743461 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03047393 0,06737359 ! icosanoid secretion GO:0032309 15 9 0,000 0,03047393 0,06731267 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03047393 0,06725186 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03047393 0,06719117 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03047393 0,06713058 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03047393 0,0670701 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03047393 0,06700973 ! sterol catabolic process GO:0016127 14 9 0,000 0,03047393 0,06694947 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03047393 0,06688932 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03047393 0,06682928 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03047393 0,06676934 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03047393 0,06670951 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03047393 0,06664979 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03047393 0,06659017 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03047393 0,06653066 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03047393 0,06647126 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03047393 0,06641197 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03047393 0,06635277 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03047393 0,06629369 ! purine base metabolic process GO:0006144 25 9 0,000 0,03047393 0,06623471 ! pigment granule transport GO:0051904 17 9 0,000 0,03047393 0,06617583 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,03047393 0,06611706 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03047393 0,0660584 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03047393 0,06599983 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03047393 0,06594138 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03047393 0,06588302 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03047393 0,06582477 ! mitochondrion localization GO:0051646 18 9 0,000 0,03047393 0,06576662 ! protein import into nucleus GO:0006606 174 82 1,000 0,03246555 0,07000295 ! response to drug GO:0042493 149 83 1,000 0,03319389 0,07151029 ! nuclear import GO:0051170 177 83 1,000 0,03319389 0,07144729 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,03380254 0,07269332 ! regulation of developmental growth GO:0048638 16 10 0,000 0,03380254 0,07262938 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,03380254 0,07256556 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,03380254 0,07250185 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,03380254 0,07243825 ! associative learning GO:0008306 21 10 0,000 0,03380254 0,07237477 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,03380254 0,07231139 ! phosphate transport GO:0006817 24 10 0,000 0,03380254 0,07224813 ! cell volume homeostasis GO:0006884 17 10 0,000 0,03380254 0,07218497 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,03380254 0,07212193 ! CTP metabolic process GO:0046036 11 10 0,000 0,03380254 0,072059 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,03380254 0,07199617 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,03380254 0,07193346 ! GTP metabolic process GO:0046039 11 10 0,000 0,03380254 0,07187085 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,03380254 0,07180836 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,03380254 0,07174597 ! social behavior GO:0035176 29 10 0,000 0,03380254 0,07168369 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,03380254 0,07162152 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,03380254 0,07155945 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,03380254 0,0714975 ! androgen metabolic process GO:0008209 17 10 0,000 0,03380254 0,07143565 ! phospholipid efflux GO:0033700 19 10 0,000 0,03380254 0,07137391 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,03380254 0,07131227 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,03380254 0,07125074 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,03380254 0,07118932 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,03380254 0,071128 ! pathogenesis GO:0009405 17 10 0,000 0,03380254 0,07106679 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03380254 0,07100568 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,03380254 0,07094468 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,03380254 0,07088378 ! endoderm development GO:0007492 18 10 0,000 0,03380254 0,07082299 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,03380254 0,0707623 ! arginine catabolic process GO:0006527 17 10 0,000 0,03380254 0,07070172 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,03380254 0,07064124 ! proline metabolic process GO:0006560 13 10 0,000 0,03380254 0,07058086 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,03380254 0,07052059 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,03380254 0,07046042 ! V(D)J recombination GO:0033151 34 10 0,000 0,03380254 0,07040035 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,03380254 0,07034038 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,03380254 0,07028052 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,03380254 0,07022076 ! B cell proliferation GO:0042100 19 10 0,000 0,03380254 0,07016109 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,03380254 0,07010154 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,03380254 0,07004208 ! multicellular organism growth GO:0035264 19 10 0,000 0,03380254 0,06998272 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,03380254 0,06992346 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,03380254 0,06986431 ! ruffle organization GO:0031529 17 10 0,000 0,03380254 0,06980525 ! epithelial cell development GO:0002064 21 10 0,000 0,03380254 0,06974629 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,03380254 0,06968743 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,03380254 0,06962868 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,03380254 0,06957002 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,03380254 0,06951146 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,03380254 0,06945299 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,03380254 0,06939463 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,03380254 0,06933636 ! protein heterooligomerization GO:0051291 17 10 0,000 0,03380254 0,0692782 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,03380254 0,06922012 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,03380254 0,06916215 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,03380254 0,06910428 ! segment specification GO:0007379 15 10 0,000 0,03380254 0,0690465 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,03380254 0,06898881 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,03380254 0,06893123 ! blastoderm segmentation GO:0007350 19 10 0,000 0,03380254 0,06887374 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,03380254 0,06881634 ! response to dsRNA GO:0043331 23 10 0,000 0,03380254 0,06875904 ! DNA ligation GO:0006266 18 10 0,000 0,03380254 0,06870184 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,03380254 0,06864473 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,03380254 0,06858771 ! melanosome localization GO:0032400 16 10 0,000 0,03380254 0,0685308 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,03380254 0,06847397 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,03380254 0,06841724 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,03380254 0,0683606 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,03380254 0,06830406 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,03380254 0,06824761 ! induction of an organ GO:0001759 17 10 0,000 0,03380254 0,06819125 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,03380254 0,06813499 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,03380254 0,06807882 ! protein sumoylation GO:0016925 17 10 0,000 0,03380254 0,06802274 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,03380254 0,06796676 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,03380254 0,06791086 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03380254 0,06785506 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,03380254 0,06779935 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,03380254 0,06774373 ! salivary gland development GO:0007431 28 10 0,000 0,03380254 0,0676882 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,03380254 0,06763277 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,03380254 0,06757742 ! midbrain development GO:0030901 14 10 0,000 0,03380254 0,06752217 ! musculoskeletal movement GO:0050881 16 10 0,000 0,03380254 0,067467 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,03380254 0,06741193 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,03380254 0,06735694 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,03380254 0,06730204 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,03380254 0,06724724 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,03380254 0,06719252 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,03380254 0,06713789 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,03380254 0,06708335 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,03380254 0,0670289 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,03380254 0,06697454 GO:0043470|regulation of carbohydrate catabolic process, ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,03380254 0,06692027 ! blastocyst formation GO:0001825 18 10 0,000 0,03380254 0,06686608 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,03380254 0,06681198 ! cerebellar cortex development GO:0021695 16 10 0,000 0,03380254 0,06675797 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,03380254 0,06670405 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,03380254 0,06665021 ! response to nicotine GO:0035094 20 10 0,000 0,03380254 0,06659646 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,03380254 0,0665428 ! response to metal ion GO:0010038 158 84 1,000 0,03392861 0,0667372 ! negative regulation of transport GO:0051051 164 85 1,000 0,03466968 0,06814 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,03541702 0,06955288 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 1,000 0,0361706 0,07097572 ! respiratory burst GO:0045730 17 11 0,000 0,03711982 0,07277987 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03711982 0,0727215 ! neuron fate specification GO:0048665 18 11 0,000 0,03711982 0,07266323 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03711982 0,07260506 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03711982 0,07254697 ! thyroid gland development GO:0030878 26 11 0,000 0,03711982 0,07248898 ! synapsis GO:0007129 14 11 0,000 0,03711982 0,07243108 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03711982 0,07237328 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03711982 0,07231556 ! response to pain GO:0048265 27 11 0,000 0,03711982 0,07225794 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,03711982 0,07220041 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03711982 0,07214297 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,03711982 0,07208562 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,03711982 0,07202837 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03711982 0,0719712 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03711982 0,07191413 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03711982 0,07185714 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03711982 0,07180025 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03711982 0,07174344 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03711982 0,07168673 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03711982 0,07163011 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03711982 0,07157357 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03711982 0,07151712 ! UV protection GO:0009650 20 11 0,000 0,03711982 0,07146077 ! adult heart development GO:0007512 16 11 0,000 0,03711982 0,0714045 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03711982 0,07134832 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03711982 0,07129223 ! macroautophagy GO:0016236 19 11 0,000 0,03711982 0,07123622 ! temperature homeostasis GO:0001659 18 11 0,000 0,03711982 0,07118031 ! behavioral fear response GO:0001662 27 11 0,000 0,03711982 0,07112448 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03711982 0,07106874 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03711982 0,07101309 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03711982 0,07095752 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03711982 0,07090204 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03711982 0,07084665 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03711982 0,07079135 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03711982 0,07073613 ! regulation of organ growth GO:0046620 14 11 0,000 0,03711982 0,07068099 ! pigment granule localization GO:0051875 20 11 0,000 0,03711982 0,07062595 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03711982 0,07057098 ! vasoconstriction GO:0042310 20 11 0,000 0,03711982 0,07051611 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03711982 0,07046132 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03711982 0,07040661 ! embryonic axis specification GO:0000578 19 11 0,000 0,03711982 0,07035199 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03711982 0,07029745 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03711982 0,070243 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03711982 0,07018863 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03711982 0,07013435 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03711982 0,07008015 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03711982 0,07002603 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03711982 0,069972 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03711982 0,06991805 ! prophase GO:0051324 17 11 0,000 0,03711982 0,06986419 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03711982 0,0698104 ! nucleosome positioning GO:0016584 15 11 0,000 0,03711982 0,0697567 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03711982 0,06970309 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03711982 0,06964955 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03711982 0,0695961 ! apical protein localization GO:0045176 18 11 0,000 0,03711982 0,06954273 ! acid secretion GO:0046717 20 11 0,000 0,03711982 0,06948944 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03711982 0,06943623 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03711982 0,0693831 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03711982 0,06933006 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03711982 0,06927709 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03711982 0,06922421 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03711982 0,06917141 ! cholesterol efflux GO:0033344 21 11 0,000 0,03711982 0,06911868 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03711982 0,06906604 ! oocyte development GO:0048599 20 11 0,000 0,03711982 0,06901348 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03711982 0,068961 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03711982 0,0689086 ! embryonic gut development GO:0048566 19 11 0,000 0,03711982 0,06885628 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03711982 0,06880403 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03711982 0,06875187 ! activation of innate immune response GO:0002218 16 11 0,000 0,03711982 0,06869978 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03711982 0,06864778 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03711982 0,06859585 ! lysogeny GO:0030069 22 11 0,000 0,03711982 0,068544 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03711982 0,06849223 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03711982 0,06844054 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03711982 0,06838892 ! regulation of embryonic development GO:0045995 35 11 0,000 0,03711982 0,06833739 ! nucleus localization GO:0051647 22 11 0,000 0,03711982 0,06828593 ! regulation of DNA binding GO:0051101 167 89 1,000 0,03769625 0,06929417 ! protein localization in nucleus GO:0034504 192 89 1,000 0,03769625 0,06924207 ! response to inorganic substance GO:0010035 173 90 1,000 0,03846823 0,07060698 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,03846823 0,07055397 ! response to unfolded protein GO:0006986 139 90 1,000 0,03846823 0,07050104 ! ossification GO:0001503 205 91 1,000 0,03924624 0,07187298 ! gland development GO:0048732 220 91 1,000 0,03924624 0,07181914 ! bone development GO:0060348 206 92 1,000 0,04003022 0,07319898 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,04003022 0,07314423 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,0404258 0,07381183 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,0404258 0,0737567 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,0404258 0,07370166 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,0404258 0,0736467 ! virus-host interaction GO:0019048 30 12 0,000 0,0404258 0,07359182 ! mating GO:0007618 17 12 0,000 0,0404258 0,07353702 ! protein complex disassembly GO:0043241 28 12 0,000 0,0404258 0,07348231 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,0404258 0,07342768 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,0404258 0,07337312 ! hippocampus development GO:0021766 29 12 0,000 0,0404258 0,07331865 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,0404258 0,07326426 ! T cell proliferation GO:0042098 32 12 0,000 0,0404258 0,07320995 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,0404258 0,07315572 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,0404258 0,07310157 ! ventral spinal cord development GO:0021517 25 12 0,000 0,0404258 0,0730475 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,0404258 0,07299351 ! drug transport GO:0015893 16 12 0,000 0,0404258 0,0729396 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,0404258 0,07288577 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,0404258 0,07283202 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,0404258 0,07277835 ! polyamine metabolic process GO:0006595 18 12 0,000 0,0404258 0,07272476 ! focal adhesion formation GO:0048041 37 12 0,000 0,0404258 0,07267125 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,0404258 0,07261781 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,0404258 0,07256445 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,0404258 0,07251118 ! lipid digestion GO:0044241 21 12 0,000 0,0404258 0,07245798 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,0404258 0,07240486 ! entry into host cell GO:0030260 34 12 0,000 0,0404258 0,07235181 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0404258 0,07229885 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,0404258 0,07224596 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,0404258 0,07219315 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,0404258 0,07214041 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,0404258 0,07208775 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,0404258 0,07203517 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,0404258 0,07198267 ! snRNA metabolic process GO:0016073 30 12 0,000 0,0404258 0,07193024 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,0404258 0,07187789 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,0404258 0,07182562 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,0404258 0,07177342 ! cranial nerve development GO:0021545 23 12 0,000 0,0404258 0,07172129 ! fucose catabolic process GO:0019317 25 12 0,000 0,0404258 0,07166925 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,0404258 0,07161728 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,0404258 0,07156538 ! autonomic nervous system development GO:0048483 24 12 0,000 0,0404258 0,07151356 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,0404258 0,07146181 ! zymogen activation GO:0031638 18 12 0,000 0,0404258 0,07141014 ! T cell homeostasis GO:0043029 28 12 0,000 0,0404258 0,07135854 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,0404258 0,07130702 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,0404258 0,07125557 ! oocyte differentiation GO:0009994 21 12 0,000 0,0404258 0,0712042 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,0404258 0,0711529 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,0404258 0,07110167 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,0404258 0,07105052 ! defense response to fungus GO:0050832 15 12 0,000 0,0404258 0,07099944 ! developmental induction GO:0031128 22 12 0,000 0,0404258 0,07094844 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,0404258 0,0708975 ! lamellipodium assembly GO:0030032 24 12 0,000 0,0404258 0,07084665 ! response to cold GO:0009409 17 12 0,000 0,0404258 0,07079586 ! establishment of cell polarity GO:0030010 21 12 0,000 0,0404258 0,07074515 ! regulation of synapse organization GO:0050807 18 12 0,000 0,0404258 0,0706945 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,04082014 0,07133306 ! regulation of membrane potential GO:0042391 179 94 1,000 0,04161595 0,07267174 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,04241759 0,07401869 ! response to protein stimulus GO:0051789 158 96 1,000 0,04322501 0,0753738 ! regulation of T cell activation GO:0050863 175 96 1,000 0,04322501 0,07532004 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,04372052 0,07612917 ! cGMP metabolic process GO:0046068 18 13 0,000 0,04372052 0,07607495 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,04372052 0,0760208 ! regulation of chemokine production GO:0032642 18 13 0,000 0,04372052 0,07596673 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,04372052 0,07591274 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,04372052 0,07585883 ! peroxisomal transport GO:0043574 28 13 0,000 0,04372052 0,07580499 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,04372052 0,07575123 ! cartilage condensation GO:0001502 22 13 0,000 0,04372052 0,07569754 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,04372052 0,07564393 ! organelle fusion GO:0048284 36 13 0,000 0,04372052 0,0755904 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,04372052 0,07553694 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,04372052 0,07548355 ! endocrine pancreas development GO:0031018 25 13 0,000 0,04372052 0,07543025 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,04372052 0,07537701 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,04372052 0,07532386 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,04372052 0,07527077 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,04372052 0,07521777 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,04372052 0,07516483 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,04372052 0,07511197 ! methionine metabolic process GO:0006555 31 13 0,000 0,04372052 0,07505919 ! plasma membrane organization GO:0007009 27 13 0,000 0,04372052 0,07500648 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,04372052 0,07495384 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,04372052 0,07490128 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,04372052 0,07484879 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,04372052 0,07479638 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,04372052 0,07474404 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,04372052 0,07469177 ! exocrine system development GO:0035272 34 13 0,000 0,04372052 0,07463957 ! asymmetric protein localization GO:0008105 24 13 0,000 0,04372052 0,07458745 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,04372052 0,0745354 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,04372052 0,07448342 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,04372052 0,07443152 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,04372052 0,07437969 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,04372052 0,07432793 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,04372052 0,07427624 ! protein homotetramerization GO:0051289 24 13 0,000 0,04372052 0,07422462 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,04372052 0,07417308 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,04372052 0,0741216 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,04372052 0,0740702 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,04372052 0,07401887 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,04372052 0,07396761 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,04372052 0,07391642 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,04372052 0,0738653 ! histone methylation GO:0016571 29 13 0,000 0,04372052 0,07381426 ! gland morphogenesis GO:0022612 31 13 0,000 0,04372052 0,07376328 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,04372052 0,07371237 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,04372052 0,07366154 ! regulation of epidermis development GO:0045682 19 13 0,000 0,04372052 0,07361077 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,04372052 0,07356007 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,04372052 0,07350945 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,04372052 0,07345889 ! spleen development GO:0048536 24 13 0,000 0,04372052 0,0734084 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,04372052 0,07335799 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,04372052 0,07330764 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,04372052 0,07325736 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,04372052 0,07320715 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,04372052 0,07315701 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,04372052 0,07310693 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,04372052 0,07305693 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,04372052 0,07300699 ! insulin secretion GO:0030073 24 13 0,000 0,04372052 0,07295712 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,04372052 0,07290732 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,04372052 0,07285759 ! acrosome reaction GO:0007340 19 13 0,000 0,04372052 0,07280793 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,04372052 0,07275833 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,04372052 0,0727088 ! rRNA transcription GO:0009303 28 14 0,000 0,04700402 0,07811621 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04700402 0,0780631 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,04700402 0,07801007 ! water transport GO:0006833 21 14 0,000 0,04700402 0,07795711 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04700402 0,07790422 ! non-recombinational repair GO:0000726 29 14 0,000 0,04700402 0,07785141 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04700402 0,07779866 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04700402 0,07774599 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04700402 0,07769338 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04700402 0,07764085 ! lipid localization GO:0010876 32 14 0,000 0,04700402 0,07758839 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04700402 0,077536 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,04700402 0,07748369 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04700402 0,07743144 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04700402 0,07737926 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04700402 0,07732715 ! arginine metabolic process GO:0006525 21 14 0,000 0,04700402 0,07727512 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04700402 0,07722315 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,04700402 0,07717125 ! regulation of heart rate GO:0002027 25 14 0,000 0,04700402 0,07711942 ! fear response GO:0042596 34 14 0,000 0,04700402 0,07706767 ! organic alcohol transport GO:0015850 29 14 0,000 0,04700402 0,07701598 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04700402 0,07696436 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,04700402 0,07691281 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,04700402 0,07686133 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04700402 0,07680991 ! bone mineralization GO:0030282 18 14 0,000 0,04700402 0,07675857 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04700402 0,0767073 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,04700402 0,07665609 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04700402 0,07660495 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04700402 0,07655388 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04700402 0,07650288 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,04700402 0,07645195 ! ribosome assembly GO:0042255 18 14 0,000 0,04700402 0,07640108 ! cerebellum development GO:0021549 23 14 0,000 0,04700402 0,07635028 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04700402 0,07629955 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,04700402 0,07624889 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04700402 0,07619829 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04700402 0,07614776 ! NADP metabolic process GO:0006739 24 14 0,000 0,04700402 0,0760973 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,04700402 0,0760469 ! oxygen transport GO:0015671 22 14 0,000 0,04700402 0,07599657 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04700402 0,07594631 ! male genitalia development GO:0030539 26 14 0,000 0,04700402 0,07589612 ! regulation of axon extension GO:0030516 43 14 0,000 0,04700402 0,07584599 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04700402 0,07579592 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04700402 0,07574593 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,05027634 0,08096579 ! lactation GO:0007595 30 15 0,000 0,05027634 0,08091245 ! reproductive cellular process GO:0048610 22 15 0,000 0,05027634 0,08085918 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,05027634 0,08080599 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,05027634 0,08075286 ! superoxide anion generation GO:0042554 22 15 0,000 0,05027634 0,0806998 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,05027634 0,08064681 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,05027634 0,0805939 ! copper ion transport GO:0006825 22 15 0,000 0,05027634 0,08054105 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,05027634 0,08048827 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,05027634 0,08043556 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,05027634 0,08038292 ! sulfate transport GO:0008272 27 15 0,000 0,05027634 0,08033035 ! response to cAMP GO:0051591 25 15 0,000 0,05027634 0,08027784 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,05027634 0,08022541 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,05027634 0,08017304 ! response to hexose stimulus GO:0009746 25 15 0,000 0,05027634 0,08012074 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,05027634 0,08006851 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,05027634 0,08001635 ! vesicle coating GO:0006901 38 15 0,000 0,05027634 0,07996426 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,05027634 0,07991223 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,05027634 0,07986027 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,05027634 0,07980838 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,05027634 0,07975656 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,05027634 0,0797048 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,05027634 0,07965311 ! regulation of vasodilation GO:0042312 27 15 0,000 0,05027634 0,07960149 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,05027634 0,07954993 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,05027634 0,07949845 ! water homeostasis GO:0030104 28 15 0,000 0,05027634 0,07944702 ! cofactor transport GO:0051181 30 15 0,000 0,05027634 0,07939567 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,05027634 0,07934438 ! muscle maintenance GO:0046716 26 15 0,000 0,05027634 0,07929316 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,05027634 0,079242 ! intestinal absorption GO:0050892 31 15 0,000 0,05027634 0,07919091 ! dopamine metabolic process GO:0042417 35 15 0,000 0,05027634 0,07913988 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,05027634 0,07908892 ! heme biosynthetic process GO:0006783 33 15 0,000 0,05027634 0,07903803 ! cell killing GO:0001906 32 15 0,000 0,05027634 0,0789872 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,05027634 0,07893644 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,05027634 0,07888574 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,05027634 0,07883511 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,05027634 0,07878454 ! actin filament polymerization GO:0030041 27 15 0,000 0,05027634 0,07873404 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,05027634 0,0786836 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,05353752 0,08373377 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,05353752 0,0836802 ! positive regulation of cell size GO:0045793 29 16 0,000 0,05353752 0,08362669 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,05353752 0,08357326 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,05353752 0,08351989 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,05353752 0,08346659 ! bone remodeling GO:0046849 28 16 0,000 0,05353752 0,08341336 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,05353752 0,0833602 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05353752 0,0833071 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,05353752 0,08325407 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,05353752 0,08320111 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,05353752 0,08314822 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,05353752 0,08309539 ! startle response GO:0001964 28 16 0,000 0,05353752 0,08304263 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,05353752 0,08298994 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,05353752 0,08293732 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,05353752 0,08288476 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,05353752 0,08283227 ! protein polyubiquitination GO:0000209 41 16 0,000 0,05353752 0,08277984 ! glutamate metabolic process GO:0006536 25 16 0,000 0,05353752 0,08272748 ! pituitary gland development GO:0021983 30 16 0,000 0,05353752 0,08267519 ! response to osmotic stress GO:0006970 27 16 0,000 0,05353752 0,08262296 ! lysosomal transport GO:0007041 31 16 0,000 0,05353752 0,0825708 ! fructose metabolic process GO:0006000 25 16 0,000 0,05353752 0,08251871 ! L-amino acid transport GO:0015807 33 16 0,000 0,05353752 0,08246668 ! stem cell development GO:0048864 46 16 0,000 0,05353752 0,08241471 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,05353752 0,08236281 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,05353752 0,08231098 ! intermediate filament-based process GO:0045103 36 16 0,000 0,05353752 0,08225921 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,05353752 0,08220751 ! negative regulation of immune response GO:0050777 38 16 0,000 0,05353752 0,08215587 ! axon cargo transport GO:0008088 46 16 0,000 0,05353752 0,0821043 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,05353752 0,08205279 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,05353752 0,08200135 ! DNA replication initiation GO:0006270 28 16 0,000 0,05353752 0,08194997 ! neuron recognition GO:0008038 40 16 0,000 0,05353752 0,08189865 ! mRNA splice site selection GO:0006376 44 16 0,000 0,05353752 0,0818474 ! tissue regeneration GO:0042246 27 16 0,000 0,05353752 0,08179622 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,05353752 0,08174509 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,05353752 0,08169403 ! biomineral formation GO:0031214 22 16 0,000 0,05353752 0,08164304 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,05353752 0,08159211 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,05353752 0,08154124 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,05353752 0,08149044 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,05353752 0,08143969 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,05353752 0,08138902 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,05353752 0,0813384 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,05353752 0,08128785 ! peptide hormone processing GO:0016486 27 16 0,000 0,05353752 0,08123736 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,05678758 0,0861155 ! metencephalon development GO:0022037 32 17 0,000 0,05678758 0,08606208 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,05678758 0,08600872 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,05678758 0,08595543 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,05678758 0,08590221 ! signal complex assembly GO:0007172 47 17 0,000 0,05678758 0,08584905 ! filopodium assembly GO:0046847 42 17 0,000 0,05678758 0,08579596 ! endothelial cell migration GO:0043542 31 17 0,000 0,05678758 0,08574293 ! gene silencing by RNA GO:0031047 38 17 0,000 0,05678758 0,08568997 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,05678758 0,08563708 ! glial cell development GO:0021782 28 17 0,000 0,05678758 0,08558425 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,05678758 0,08553148 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,05678758 0,08547878 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,05678758 0,08542615 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,05678758 0,08537358 ! myoblast differentiation GO:0045445 50 17 0,000 0,05678758 0,08532107 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,05678758 0,08526863 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,05678758 0,08521626 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,05678758 0,08516394 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,05678758 0,0851117 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,05678758 0,08505951 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,05678758 0,08500739 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,05678758 0,08495534 ! membrane budding GO:0006900 42 17 0,000 0,05678758 0,08490335 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,05678758 0,08485142 ! regulation of protein binding GO:0043393 33 17 0,000 0,05678758 0,08479955 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,05678758 0,08474775 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,05678758 0,08469601 ! genitalia development GO:0048806 32 17 0,000 0,05678758 0,08464434 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,05678758 0,08459272 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,05678758 0,08454117 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,05678758 0,08448969 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,05678758 0,08443826 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,05678758 0,0843869 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,05678758 0,0843356 ! steroid catabolic process GO:0006706 34 17 0,000 0,05678758 0,08428437 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,05678758 0,08423319 ! gas transport GO:0015669 26 17 0,000 0,05678758 0,08418208 ! organic cation transport GO:0015695 32 17 0,000 0,05678758 0,08413103 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,05678758 0,08408004 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,05678758 0,08402911 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,06002658 0,08876812 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,06002658 0,08871442 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,06002658 0,08866079 ! limbic system development GO:0021761 40 18 0,000 0,06002658 0,08860721 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,06002658 0,08855371 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,06002658 0,08850027 ! adult walking behavior GO:0007628 36 18 0,000 0,06002658 0,08844689 ! patterning of blood vessels GO:0001569 43 18 0,000 0,06002658 0,08839357 ! heart looping GO:0001947 34 18 0,000 0,06002658 0,08834033 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,06002658 0,08828714 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,06002658 0,08823402 ! centrosome cycle GO:0007098 26 18 0,000 0,06002658 0,08818096 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,06002658 0,08812797 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,06002658 0,08807504 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,06002658 0,08802217 ! glycine metabolic process GO:0006544 30 18 0,000 0,06002658 0,08796937 ! glutamine metabolic process GO:0006541 29 18 0,000 0,06002658 0,08791663 ! response to retinoic acid GO:0032526 31 18 0,000 0,06002658 0,08786395 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,06002658 0,08781134 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,06002658 0,08775879 ! DNA integration GO:0015074 32 18 0,000 0,06002658 0,0877063 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,06002658 0,08765388 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,06002658 0,08760152 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,06002658 0,08754922 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,06002658 0,08749698 ! neural crest cell migration GO:0001755 41 18 0,000 0,06002658 0,08744481 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,06002658 0,08739269 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,06002658 0,08734064 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,06002658 0,08728866 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,06002658 0,08723673 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,06002658 0,08718486 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,06002658 0,08713306 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,06002658 0,08708132 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,06002658 0,08702964 ! detection of bacterium GO:0016045 22 18 0,000 0,06002658 0,08697802 ! nerve development GO:0021675 34 18 0,000 0,06002658 0,08692646 ! microspike assembly GO:0030035 46 18 0,000 0,06002658 0,08687496 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,06002658 0,08682353 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,06002658 0,08677215 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,06325455 0,09138431 ! positive regulation of translation GO:0045727 31 19 0,000 0,06325455 0,0913303 ! negative regulation of defense response GO:0031348 27 19 0,000 0,06325455 0,09127635 ! neuron maturation GO:0042551 46 19 0,000 0,06325455 0,09122247 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,06325455 0,09116865 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,06325455 0,0911149 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,06325455 0,0910612 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,06325455 0,09100758 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,06325455 0,09095401 ! inositol metabolic process GO:0006020 33 19 0,000 0,06325455 0,09090051 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,06325455 0,09084707 ! memory GO:0007613 34 19 0,000 0,06325455 0,09079369 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,06325455 0,09074038 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,06325455 0,09068713 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,06325455 0,09063394 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,06325455 0,09058081 ! cerebral cortex development GO:0021987 40 19 0,000 0,06325455 0,09052775 ! pigmentation during development GO:0048066 42 19 0,000 0,06325455 0,09047474 ! response to vitamin A GO:0033189 32 19 0,000 0,06325455 0,0904218 ! heme metabolic process GO:0042168 40 19 0,000 0,06325455 0,09036893 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,06325455 0,09031611 ! response to fungus GO:0009620 26 19 0,000 0,06325455 0,09026336 ! peptide cross-linking GO:0018149 39 19 0,000 0,06325455 0,09021066 ! protein export from nucleus GO:0006611 40 19 0,000 0,06325455 0,09015803 ! heart process GO:0003015 32 19 0,000 0,06325455 0,09010546 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,06325455 0,09005295 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,06325455 0,0900005 ! visual learning GO:0008542 38 19 0,000 0,06325455 0,08994812 ! cellular pigmentation GO:0033059 37 19 0,000 0,06325455 0,08989579 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,06325455 0,08984353 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,06325455 0,08979132 ! vitamin transport GO:0051180 31 19 0,000 0,06325455 0,08973918 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,06325455 0,08968709 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,06325455 0,08963507 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,06325455 0,08958311 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,06325455 0,08953121 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,06325455 0,08947937 ! cilium assembly GO:0042384 38 19 0,000 0,06325455 0,08942758 ! peptide hormone secretion GO:0030072 32 19 0,000 0,06325455 0,08937586 ! protein secretion GO:0009306 45 20 0,000 0,06647152 0,09386701 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,06647152 0,09381278 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,06647152 0,09375862 ! positive regulation of ossification GO:0045778 50 20 0,000 0,06647152 0,09370452 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,06647152 0,09365048 ! skin development GO:0043588 42 20 0,000 0,06647152 0,0935965 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,06647152 0,09354259 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,06647152 0,09348873 ! response to vitamin GO:0033273 36 20 0,000 0,06647152 0,09343494 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,06647152 0,09338121 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,06647152 0,09332754 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,06647152 0,09327394 ! bile acid metabolic process GO:0008206 34 20 0,000 0,06647152 0,09322039 ! response to alkaloid GO:0043279 38 20 0,000 0,06647152 0,09316691 ! retinoid metabolic process GO:0001523 34 20 0,000 0,06647152 0,09311349 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,06647152 0,09306013 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,06647152 0,09300683 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,06647152 0,09295359 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,06647152 0,09290042 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,06647152 0,0928473 ! actin filament bundle formation GO:0051017 47 20 0,000 0,06647152 0,09279424 ! body fluid secretion GO:0007589 33 20 0,000 0,06647152 0,09274125 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,06647152 0,09268831 ! peptide secretion GO:0002790 38 20 0,000 0,06647152 0,09263544 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,06647152 0,09258263 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,06647152 0,09252987 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,06647152 0,09247718 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,06647152 0,09242455 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,06647152 0,09237197 ! cell-cell junction organization GO:0045216 43 20 0,000 0,06647152 0,09231946 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,06647152 0,092267 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,06647152 0,09221461 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,06647152 0,09216227 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,06647152 0,09211 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,06647152 0,09205778 ! regulation of glucose import GO:0046324 30 20 0,000 0,06647152 0,09200562 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,06647152 0,09195353 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,06647152 0,09190149 ! negative regulation of translation GO:0017148 32 20 0,000 0,06647152 0,09184951 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,06647152 0,09179758 ! regulation of cell killing GO:0031341 46 21 0,000 0,06967754 0,09617075 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,06967754 0,09611644 ! hormone secretion GO:0046879 39 21 0,000 0,06967754 0,0960622 ! cAMP metabolic process GO:0046058 41 21 0,000 0,06967754 0,09600802 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,06967754 0,0959539 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,06967754 0,09589984 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,06967754 0,09584585 ! ovarian follicle development GO:0001541 39 21 0,000 0,06967754 0,09579191 ! smooth muscle contraction GO:0006939 48 21 0,000 0,06967754 0,09573803 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,06967754 0,09568422 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,06967754 0,09563046 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,06967754 0,09557677 ! plasma membrane fusion GO:0045026 33 21 0,000 0,06967754 0,09552313 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,06967754 0,09546956 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,06967754 0,09541604 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,06967754 0,09536259 ! sensory perception of pain GO:0019233 33 21 0,000 0,06967754 0,0953092 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,06967754 0,09525586 ! diencephalon development GO:0021536 36 21 0,000 0,06967754 0,09520259 ! collagen fibril organization GO:0030199 62 21 0,000 0,06967754 0,09514937 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,06967754 0,09509621 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,06967754 0,09504312 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,06967754 0,09499008 ! collagen catabolic process GO:0030574 29 21 0,000 0,06967754 0,0949371 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,06967754 0,09488418 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,06967754 0,09483132 ! sperm-egg recognition GO:0035036 23 21 0,000 0,06967754 0,09477852 ! actin filament-based movement GO:0030048 47 21 0,000 0,06967754 0,09472578 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,07287263 0,09901437 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,07287263 0,09895933 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,07287263 0,09890435 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,07287263 0,09884944 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,07287263 0,09879458 ! microtubule-based transport GO:0010970 59 22 0,000 0,07287263 0,09873979 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,07287263 0,09868505 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,07287263 0,09863038 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,07287263 0,09857577 ! vacuolar transport GO:0007034 41 22 0,000 0,07287263 0,09852122 ! central nervous system neuron development GO:0021954 47 22 0,000 0,07287263 0,09846672 ! fucose metabolic process GO:0006004 44 22 0,000 0,07287263 0,09841229 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,07287263 0,09835792 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,07287263 0,09830361 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,07287263 0,09824936 ! ureteric bud development GO:0001657 50 22 0,000 0,07287263 0,09819517 ! stem cell differentiation GO:0048863 57 22 0,000 0,07287263 0,09814104 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,07287263 0,09808696 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,07287263 0,09803295 ! cytolysis GO:0019835 27 22 0,000 0,07287263 0,097979 ! renal system process GO:0003014 42 22 0,000 0,07287263 0,0979251 ! vasodilation GO:0042311 40 22 0,000 0,07287263 0,09787127 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,07287263 0,09781749 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,07287263 0,09776378 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,07287263 0,09771012 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,07287263 0,09765652 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,07287263 0,09760298 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,07287263 0,0975495 ! sarcomere organization GO:0045214 32 22 0,000 0,07287263 0,09749608 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,07287263 0,09744271 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,07287263 0,09738941 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,07287263 0,09733616 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,07287263 0,09728297 ! gut development GO:0048565 44 22 0,000 0,07287263 0,09722984 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,07287263 0,09717677 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,07287263 0,09712375 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,07287263 0,0970708 ! protein stabilization GO:0050821 41 22 0,000 0,07287263 0,0970179 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,07605684 0,101202 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,07605684 0,10114691 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,07605684 0,10109187 ! gluconeogenesis GO:0006094 38 23 0,000 0,07605684 0,1010369 ! glycerol metabolic process GO:0006071 40 23 0,000 0,07605684 0,10098199 ! viral genome replication GO:0019079 44 23 0,000 0,07605684 0,10092714 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,07605684 0,10087235 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,07605684 0,10081762 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,07605684 0,10076294 ! regeneration GO:0031099 42 23 0,000 0,07605684 0,10070833 ! axis specification GO:0009798 43 23 0,000 0,07605684 0,10065377 ! visual behavior GO:0007632 46 23 0,000 0,07605684 0,10059928 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,07605684 0,10054484 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,07605684 0,10049046 ! response to ethanol GO:0045471 47 23 0,000 0,07605684 0,10043614 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,07605684 0,10038188 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,07605684 0,10032768 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,07605684 0,10027354 ! peroxisome organization GO:0007031 43 23 0,000 0,07605684 0,10021945 ! lysosome organization GO:0007040 47 23 0,000 0,07605684 0,10016543 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,07605684 0,10011146 ! vesicle targeting GO:0006903 49 23 0,000 0,07605684 0,10005755 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,07605684 0,10000369 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,07605684 0,0999499 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,07605684 0,09989616 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,07605684 0,09984249 ! DNA modification GO:0006304 36 23 0,000 0,07605684 0,09978886 ! fatty acid transport GO:0015908 47 23 0,000 0,07605684 0,0997353 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,07605684 0,09968179 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,07605684 0,09962835 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,07605684 0,09957495 ! hormone transport GO:0009914 41 23 0,000 0,07605684 0,09952162 ! cell-cell recognition GO:0009988 28 23 0,000 0,07605684 0,09946834 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,07605684 0,09941512 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,07605684 0,09936196 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,07605684 0,09930885 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,07923021 0,10339711 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,07923021 0,10334191 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,07923021 0,10328676 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,07923021 0,10323168 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,07923021 0,10317665 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,07923021 0,10312168 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,07923021 0,10306677 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,07923021 0,10301192 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,07923021 0,10295712 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,07923021 0,10290239 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,07923021 0,10284771 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,07923021 0,10279309 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,07923021 0,10273853 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,07923021 0,10268403 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,07923021 0,10262958 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,07923021 0,1025752 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,07923021 0,10252087 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,07923021 0,10246659 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,07923021 0,10241238 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,07923021 0,10235822 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,07923021 0,10230412 ! membrane depolarization GO:0051899 45 24 0,000 0,07923021 0,10225008 ! pallium development GO:0021543 56 24 0,000 0,07923021 0,10219609 ! oogenesis GO:0048477 44 24 0,000 0,07923021 0,10214216 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,07923021 0,10208829 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,07923021 0,10203447 ! platelet activation GO:0030168 41 24 0,000 0,07923021 0,10198071 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,07923021 0,10192701 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,07923021 0,10187337 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,07923021 0,10181978 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,07923021 0,10176624 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,07923021 0,10171277 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,07923021 0,10165935 ! regulation of amine transport GO:0051952 41 24 0,000 0,07923021 0,10160598 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,07923021 0,10155267 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,08239276 0,10555087 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,08239276 0,10549555 ! leukocyte adhesion GO:0007159 55 25 0,000 0,08239276 0,10544029 ! phototransduction GO:0007602 37 25 0,000 0,08239276 0,10538509 ! keratinization GO:0031424 37 25 0,000 0,08239276 0,10532994 ! vacuole organization GO:0007033 49 25 0,000 0,08239276 0,10527485 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,08239276 0,10521982 ! receptor metabolic process GO:0043112 53 25 0,000 0,08239276 0,10516484 ! chromosome condensation GO:0030261 48 25 0,000 0,08239276 0,10510993 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,08239276 0,10505507 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,08239276 0,10500027 ! interaction with host GO:0051701 66 25 0,000 0,08239276 0,10494552 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,08239276 0,10489084 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,08239276 0,1048362 ! immunoglobulin production GO:0002377 62 25 0,000 0,08239276 0,10478163 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,08239276 0,10472711 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,08239276 0,10467265 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,08239276 0,10461825 ! liver development GO:0001889 55 25 0,000 0,08239276 0,1045639 ! initiation of viral infection GO:0019059 60 26 0,000 0,08554454 0,10850743 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,08554454 0,10845112 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,08554454 0,10839487 ! molting cycle process GO:0022404 52 26 0,000 0,08554454 0,10833868 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,08554454 0,10828255 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,08554454 0,10822647 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,08554454 0,10817045 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,08554454 0,10811449 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,08554454 0,10805859 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,08554454 0,10800275 ! digestive system process GO:0022600 49 26 0,000 0,08554454 0,10794696 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,08554454 0,10789123 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,08554454 0,10783556 ! osteoblast differentiation GO:0001649 63 26 0,000 0,08554454 0,10777994 ! neural crest cell development GO:0014032 59 26 0,000 0,08554454 0,10772439 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,08554454 0,10766889 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,08554454 0,10761345 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,08554454 0,10755806 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,08554454 0,10750273 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,08554454 0,10744746 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,08554454 0,10739225 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,08554454 0,10733709 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,08554454 0,10728199 GO:0045840|positive regulation of mitosis, ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,08554454 0,10722694 ! blastocyst development GO:0001824 50 26 0,000 0,08554454 0,10717195 ! telomere organization GO:0032200 46 26 0,000 0,08554454 0,10711702 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,08554454 0,10706215 ! neural tube closure GO:0001843 58 26 0,000 0,08554454 0,10700733 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,08554454 0,10695257 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,08554454 0,10689786 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,08554454 0,10684321 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,08868558 0,1107097 ! embryonic pattern specification GO:0009880 49 27 0,000 0,08868558 0,11065316 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,08868558 0,11059667 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,08868558 0,11054024 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,08868558 0,11048388 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,08868558 0,11042756 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,08868558 0,11037131 ! iron ion transport GO:0006826 65 27 0,000 0,08868558 0,11031511 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,08868558 0,11025897 ! superoxide metabolic process GO:0006801 41 27 0,000 0,08868558 0,11020289 ! tube lumen formation GO:0035148 59 27 0,000 0,08868558 0,11014686 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,08868558 0,11009089 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,08868558 0,11003498 ! response to toxin GO:0009636 49 27 0,000 0,08868558 0,10997913 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,08868558 0,10992333 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,08868558 0,10986759 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,08868558 0,1098119 ! leukocyte proliferation GO:0070661 59 27 0,000 0,08868558 0,10975627 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,09181593 0,11357281 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,09181593 0,11351534 ! vesicle docking GO:0048278 55 28 0,000 0,09181593 0,11345792 ! circadian rhythm GO:0007623 56 28 0,000 0,09181593 0,11340056 ! dendrite development GO:0016358 67 28 0,000 0,09181593 0,11334326 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,09181593 0,11328601 ! fat cell differentiation GO:0045444 57 28 0,000 0,09181593 0,11322883 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,09181593 0,1131717 ! sperm motility GO:0030317 37 28 0,000 0,09181593 0,11311463 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,09181593 0,11305761 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,09181593 0,11300066 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,09181593 0,11294376 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,09181593 0,11288692 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,09181593 0,11283013 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,09181593 0,11277341 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,09181593 0,11271674 ! glutathione metabolic process GO:0006749 42 28 0,000 0,09181593 0,11266012 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,09181593 0,11260357 ! lipid oxidation GO:0034440 48 28 0,000 0,09181593 0,11254707 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,09181593 0,11249062 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,09181593 0,11243424 ! translational initiation GO:0006413 66 29 0,000 0,0949356 0,11619623 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,0949356 0,11613805 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,0949356 0,11607992 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,0949356 0,11602185 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,0949356 0,11596384 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,0949356 0,11590589 ! primary neural tube formation GO:0014020 61 29 0,000 0,0949356 0,11584799 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,0949356 0,11579015 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,0949356 0,11573237 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,0949356 0,11567465 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,0949356 0,11561699 ! synaptogenesis GO:0007416 46 29 0,000 0,0949356 0,11555938 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,0949356 0,11550183 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,0949356 0,11544434 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,0949356 0,1153869 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,0949356 0,11532953 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,09804465 0,11904726 ! phenol metabolic process GO:0018958 56 30 0,000 0,09804465 0,11898812 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,09804465 0,11892904 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,09804465 0,11887002 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,09804465 0,11881105 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,09804465 0,11875215 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,09804465 0,1186933 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,09804465 0,11863451 ! acute-phase response GO:0006953 50 30 0,000 0,09804465 0,11857578 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,09804465 0,11851711 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,09804465 0,1184585 ! myofibril assembly GO:0030239 50 30 0,000 0,09804465 0,11839994 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,09804465 0,11834144 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,09804465 0,118283 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,09804465 0,11822462 ! cell fate determination GO:0001709 64 30 0,000 0,09804465 0,1181663 ! phospholipid transport GO:0015914 65 30 0,000 0,09804465 0,11810803 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,09804465 0,11804982 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,09804465 0,11799167 GO:0046496|nicotinamide nucleotide metabolic process, ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,09804465 0,11793357 GO:0043433|negative regulation of transcription factor activity, ! regulation of coagulation GO:0050818 52 30 0,000 0,09804465 0,11787553 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,10114311 0,12154088 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,10114311 0,12148113 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,10114311 0,12142143 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,10114311 0,12136179 ! cell junction assembly GO:0034329 85 31 0,000 0,10114311 0,12130221 ! regulation of innate immune response GO:0045088 57 31 0,000 0,10114311 0,12124269 ! ovulation cycle process GO:0022602 55 31 0,000 0,10114311 0,12118323 ! peptide transport GO:0015833 60 31 0,000 0,10114311 0,12112383 ! male gonad development GO:0008584 56 31 0,000 0,10114311 0,12106448 ! iron ion homeostasis GO:0055072 60 31 0,000 0,10114311 0,1210052 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,10114311 0,12094597 ! detection of light stimulus GO:0009583 44 31 0,000 0,10114311 0,1208868 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,10114311 0,12082768 ! natural killer cell activation GO:0030101 50 31 0,000 0,10114311 0,12076863 ! cofactor catabolic process GO:0051187 54 31 0,000 0,10114311 0,12070963 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,10114311 0,12065069 ! eye morphogenesis GO:0048592 65 31 0,000 0,10114311 0,12059181 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,10114311 0,12053298 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,10423101 0,12415229 ! collagen metabolic process GO:0032963 49 32 0,000 0,10423101 0,12409179 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,10423101 0,12403134 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,10423101 0,12397096 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,10423101 0,12391063 ! metanephros development GO:0001656 81 32 0,000 0,10423101 0,12385036 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,10423101 0,12379015 ! muscle cell development GO:0055001 52 32 0,000 0,10423101 0,12373 ! mesoderm formation GO:0001707 73 32 0,000 0,10423101 0,12366991 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,10423101 0,12360988 ! ovulation cycle GO:0042698 57 32 0,000 0,10423101 0,1235499 ! BMP signaling pathway GO:0030509 71 32 0,000 0,10423101 0,12348998 ! hindbrain development GO:0030902 65 32 0,000 0,10423101 0,12343012 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,10423101 0,12337032 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,10423101 0,12331058 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,10730838 0,12688982 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,10730838 0,12682844 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,10730838 0,12676711 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,10730838 0,12670584 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,10730838 0,12664463 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,10730838 0,12658348 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,10730838 0,12652238 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,10730838 0,12646135 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,10730838 0,12640038 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,10730838 0,12633946 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,10730838 0,1262786 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,11037527 0,12982513 ! glial cell differentiation GO:0010001 67 34 0,000 0,11037527 0,12976265 ! post-embryonic development GO:0009791 76 34 0,000 0,11037527 0,12970024 ! cholesterol transport GO:0030301 62 34 0,000 0,11037527 0,12963788 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,11037527 0,12957559 ! spliceosome assembly GO:0000245 75 34 0,000 0,11037527 0,12951335 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,11037527 0,12945117 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,11037527 0,12938906 ! formation of primary germ layer GO:0001704 76 34 0,000 0,11037527 0,129327 ! cell fate specification GO:0001708 56 34 0,000 0,11037527 0,129265 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,11037527 0,12920306 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,11037527 0,12914118 ! adult locomotory behavior GO:0008344 62 34 0,000 0,11037527 0,12907937 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,11037527 0,1290176 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,11343171 0,13252687 ! negative regulation of secretion GO:0051048 68 35 0,000 0,11343171 0,13246352 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,11343171 0,13240023 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,11343171 0,132337 ! membrane docking GO:0022406 69 35 0,000 0,11343171 0,13227383 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,11343171 0,13221072 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,11343171 0,13214768 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,11343171 0,13208469 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,11343171 0,13202176 ! ceramide metabolic process GO:0006672 72 35 0,000 0,11343171 0,13195889 ! telencephalon development GO:0021537 81 35 0,000 0,11343171 0,13189609 ! sterol transport GO:0015918 63 35 0,000 0,11343171 0,13183334 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,11343171 0,13177065 ! placenta development GO:0001890 53 35 0,000 0,11343171 0,13170802 ! vesicle localization GO:0051648 70 35 0,000 0,11343171 0,13164545 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,11647774 0,13511639 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,11647774 0,13505226 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,11647774 0,1349882 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,11647774 0,13492419 ! positive regulation of cell development GO:0010720 85 36 0,000 0,11647774 0,13486025 ! protein targeting to membrane GO:0006612 75 36 0,000 0,11647774 0,13479636 ! regulation of proteolysis GO:0030162 77 36 0,000 0,11647774 0,13473254 ! aerobic respiration GO:0009060 56 36 0,000 0,11647774 0,13466877 ! cytokine production GO:0001816 68 36 0,000 0,11647774 0,13460507 ! embryonic organ development GO:0048568 67 36 0,000 0,11647774 0,13454143 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,11647774 0,13447785 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,11647774 0,13441432 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,11951339 0,13785231 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,11951339 0,13778726 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,11951339 0,13772227 ! sister chromatid segregation GO:0000819 65 37 0,000 0,11951339 0,13765733 ! odontogenesis GO:0042476 74 37 0,000 0,11951339 0,13759246 ! actomyosin structure organization GO:0031032 68 37 0,000 0,11951339 0,13752765 ! cell junction organization GO:0034330 96 37 0,000 0,11951339 0,1374629 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,11951339 0,13739821 ! female gonad development GO:0008585 71 37 0,000 0,11951339 0,13733359 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,11951339 0,13726902 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,11951339 0,13720451 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,12253869 0,14061156 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,12253869 0,14054555 ! meiosis I GO:0007127 74 38 0,000 0,12253869 0,14047959 ! organic anion transport GO:0015711 82 38 0,000 0,12253869 0,1404137 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,12253869 0,14034787 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,12253869 0,14028211 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,12253869 0,1402164 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,12253869 0,14015076 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,12253869 0,14008517 ! regulation of protein stability GO:0031647 77 38 0,000 0,12253869 0,14001965 ! spermatid development GO:0007286 69 38 0,000 0,12253869 0,13995419 ! glycogen metabolic process GO:0005977 63 38 0,000 0,12253869 0,13988879 ! pigment metabolic process GO:0042440 87 38 0,000 0,12253869 0,13982345 ! neural tube formation GO:0001841 79 38 0,000 0,12253869 0,13975818 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,12555368 0,14313002 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,12555368 0,14306326 ! negative regulation of binding GO:0051100 71 39 0,000 0,12555368 0,14299657 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,12555368 0,14292993 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,12555368 0,14286336 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,12555368 0,14279685 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,12555368 0,1427304 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,12555368 0,14266402 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,12555368 0,14259769 ! glucan metabolic process GO:0044042 64 39 0,000 0,12555368 0,14253143 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,1285584 0,14587467 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,1285584 0,14580694 ! learning GO:0007612 82 40 0,000 0,1285584 0,14573929 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,1285584 0,14567169 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,1285584 0,14560415 ! lipid homeostasis GO:0055088 75 40 0,000 0,1285584 0,14553668 ! mismatch repair GO:0006298 58 40 0,000 0,1285584 0,14546927 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,1285584 0,14540193 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,1285584 0,14533464 ! RNA export from nucleus GO:0006405 61 41 0,000 0,13155287 0,14865109 ! mRNA catabolic process GO:0006402 79 41 0,000 0,13155287 0,14858237 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,13155287 0,14851371 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,13155287 0,14844511 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,13155287 0,14837658 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,13155287 0,14830811 ! gliogenesis GO:0042063 91 41 0,000 0,13155287 0,1482397 ! feeding behavior GO:0007631 69 41 0,000 0,13155287 0,14817135 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,13155287 0,14810307 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,13155287 0,14803485 ! spermatid differentiation GO:0048515 73 41 0,000 0,13155287 0,1479667 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,13155287 0,1478986 ! organic ether metabolic process GO:0018904 59 42 0,000 0,13453714 0,1511841 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,13453714 0,15111459 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,13453714 0,15104515 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,13453714 0,15097576 ! regulation of protein secretion GO:0050708 77 42 0,000 0,13453714 0,15090644 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,13453714 0,15083719 ! cytokinesis GO:0000910 84 42 0,000 0,13453714 0,150768 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,13453714 0,15069887 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,13751124 0,15395965 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,13751124 0,15388913 ! regulation of tube size GO:0035150 76 43 0,000 0,13751124 0,15381866 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,13751124 0,15374827 ! glucose transport GO:0015758 66 43 0,000 0,13751124 0,15367793 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,13751124 0,15360766 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,13751124 0,15353746 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,13751124 0,15346732 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,13751124 0,15339724 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,13751124 0,15332723 ! ion transmembrane transport GO:0034220 79 43 0,000 0,13751124 0,15325728 ! neuron migration GO:0001764 85 43 0,000 0,13751124 0,1531874 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,13751124 0,15311758 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,1404752 0,15634666 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,1404752 0,15627546 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,1404752 0,15620433 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,1404752 0,15613327 ! hexose transport GO:0008645 68 44 0,000 0,1404752 0,15606227 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,1404752 0,15599133 ! striated muscle contraction GO:0006941 85 44 0,000 0,1404752 0,15592045 ! phagocytosis GO:0006909 105 44 0,000 0,1404752 0,15584965 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,1404752 0,1557789 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,14342906 0,1589824 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,14342906 0,1589103 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,14342906 0,15883826 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,14342906 0,15876629 ! biopolymer methylation GO:0043414 91 45 0,000 0,14342906 0,15869438 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,14342906 0,15862254 ! female gamete generation GO:0007292 71 45 0,000 0,14342906 0,15855077 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,14342906 0,15847906 ! polyol metabolic process GO:0019751 77 45 0,000 0,14342906 0,15840741 ! developmental growth GO:0048589 88 45 0,000 0,14342906 0,15833583 ! maintenance of location in cell GO:0051651 101 45 0,000 0,14342906 0,15826432 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,14637285 0,16143968 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,14637285 0,16136682 ! glycolysis GO:0006096 71 46 0,000 0,14637285 0,16129404 ! leukocyte migration GO:0050900 75 46 0,000 0,14637285 0,16122132 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,14637285 0,16114866 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,14637285 0,16107607 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,14637285 0,16100355 ! pigmentation GO:0043473 103 46 0,000 0,14637285 0,16093109 ! cell growth GO:0016049 90 46 0,000 0,14637285 0,1608587 ! neural tube development GO:0021915 91 47 0,000 0,14930661 0,16400902 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,14930661 0,1639353 ! positive regulation of defense response GO:0031349 88 48 0,000 0,15223037 0,16707044 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,15223037 0,16699542 ! cellular component disassembly GO:0022411 89 48 0,000 0,15223037 0,16692046 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,15223037 0,16684558 ! endosome transport GO:0016197 127 48 0,000 0,15223037 0,16677076 ! male sex differentiation GO:0046661 93 48 0,000 0,15223037 0,16669601 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,15223037 0,16662132 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,15223037 0,1665467 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,15223037 0,16647215 ! methylation GO:0032259 97 48 0,000 0,15223037 0,16639767 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,15514416 0,16950679 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,15514416 0,16943101 ! JNK cascade GO:0007254 106 49 0,000 0,15514416 0,16935531 ! regulation of ion transport GO:0043269 86 50 0,000 0,15804802 0,1724481 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,15804802 0,17237112 ! endocrine system development GO:0035270 109 50 0,000 0,15804802 0,1722942 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,15804802 0,17221735 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,15804802 0,17214057 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,15804802 0,17206386 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,15804802 0,17198722 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,15804802 0,17191064 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,16094197 0,17498053 ! viral infectious cycle GO:0019058 104 51 0,000 0,16094197 0,17490269 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,16094197 0,17482492 ! peptide metabolic process GO:0006518 80 51 0,000 0,16094197 0,17474722 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,16094197 0,17466959 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,16382607 0,17772073 ! Notch signaling pathway GO:0007219 111 52 0,000 0,16382607 0,17764185 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,16382607 0,17756303 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,16382607 0,17748429 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,16382607 0,17740562 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,16382607 0,17732702 ! excretion GO:0007588 87 52 0,000 0,16382607 0,17724848 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,16382607 0,17717002 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,16382607 0,17709163 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,16382607 0,1770133 ! amino acid activation GO:0043038 98 52 0,000 0,16382607 0,17693505 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,16670033 0,17995974 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,16670033 0,17988025 ! vesicle organization GO:0016050 127 53 0,000 0,16670033 0,17980084 ! cartilage development GO:0051216 99 53 0,000 0,16670033 0,17972149 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,16956479 0,18272906 ! neuromuscular process GO:0050905 107 54 0,000 0,16956479 0,18264849 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,16956479 0,18256799 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,16956479 0,18248756 ! membrane fusion GO:0006944 122 54 0,000 0,16956479 0,18240721 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,16956479 0,18232692 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,16956479 0,18224671 ! RNA catabolic process GO:0006401 103 55 0,000 0,17241948 0,18523342 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,17241948 0,185152 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,17241948 0,18507065 ! cell recognition GO:0008037 98 55 0,000 0,17241948 0,18498937 ! cell maturation GO:0048469 107 55 0,000 0,17241948 0,18490816 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,17241948 0,18482702 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,17241948 0,18474596 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,17526444 0,18771198 ! glucose catabolic process GO:0006007 88 56 0,000 0,17526444 0,18762972 ! chloride transport GO:0006821 102 57 0,000 0,1780997 0,1905815 ! heart morphogenesis GO:0003007 105 57 0,000 0,1780997 0,19049806 ! regulation of actin filament length GO:0030832 118 58 0,000 0,1809253 0,19343567 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,1809253 0,19335105 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,1809253 0,1932665 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,1809253 0,19318203 ! gastrulation GO:0007369 122 58 0,000 0,1809253 0,19309764 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,1809253 0,19301332 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,1809253 0,19292907 ! maintenance of location GO:0051235 124 58 0,000 0,1809253 0,19284489 ! nuclear export GO:0051168 110 59 0,000 0,18374125 0,19576096 ! establishment of organelle localization GO:0051656 122 59 0,000 0,18374125 0,19567562 ! DNA catabolic process GO:0006308 94 60 0,000 0,18654761 0,1985777 ! regulation of endocytosis GO:0030100 104 60 0,000 0,18654761 0,19849121 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,18654761 0,19840479 ! adult behavior GO:0030534 104 60 0,000 0,18654761 0,19831846 ! kidney development GO:0001822 133 60 0,000 0,18654761 0,19823219 ! positive regulation of secretion GO:0051047 110 61 0,000 0,1893444 0,20111668 ! regulation of cellular component size GO:0032535 125 61 0,000 0,1893444 0,20102928 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,1893444 0,20094195 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,1893444 0,2008547 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,1893444 0,20076752 ! regulation of heart contraction GO:0008016 123 61 0,000 0,1893444 0,20068042 ! camera-type eye development GO:0043010 126 61 0,000 0,1893444 0,20059339 ! proton transport GO:0015992 117 61 0,000 0,1893444 0,20050644 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,1893444 0,20041957 ! viral reproductive process GO:0022415 132 62 0,000 0,19213165 0,20328177 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,19213165 0,20319377 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,19490939 0,20604225 ! regulation of mitosis GO:0007088 112 63 0,000 0,19490939 0,20595313 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,19490939 0,20586409 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,19490939 0,20577513 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,19490939 0,20568624 ! hydrogen transport GO:0006818 121 64 0,000 0,19767766 0,2085175 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,19767766 0,20842751 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,19767766 0,20833759 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,2004365 0,2111541 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,2004365 0,21106309 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,2004365 0,21097215 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,2004365 0,21088129 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,2004365 0,21079051 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,20318592 0,21359002 ! gonad development GO:0008406 115 66 0,000 0,20318592 0,21349815 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,20592596 0,21628423 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,20592596 0,21619129 ! secondary metabolic process GO:0019748 125 67 0,000 0,20592596 0,21609842 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,20592596 0,21600564 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,20865666 0,21877606 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,20865666 0,21868221 ! hexose catabolic process GO:0019320 113 68 0,000 0,20865666 0,21858843 ! extracellular matrix organization GO:0030198 146 68 0,000 0,20865666 0,21849474 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,20865666 0,21840112 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,20865666 0,21830759 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,20865666 0,21821414 ! viral reproduction GO:0016032 142 68 0,000 0,20865666 0,21812076 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,20865666 0,21802747 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,21137805 0,22077664 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,21137805 0,2206823 ! urogenital system development GO:0001655 149 69 0,000 0,21137805 0,22058803 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,21137805 0,22049384 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,21137805 0,22039973 ! developmental maturation GO:0021700 128 69 0,000 0,21137805 0,2203057 ! single fertilization GO:0007338 83 69 0,000 0,21137805 0,22021176 ! cell redox homeostasis GO:0045454 114 70 0,000 0,21409015 0,22294213 ! germ cell development GO:0007281 133 70 0,000 0,21409015 0,22284714 ! activation of immune response GO:0002253 120 70 0,000 0,21409015 0,22275223 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,21409015 0,2226574 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,216793 0,22537247 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,216793 0,22527661 ! carbohydrate transport GO:0008643 114 72 0,000 0,21948664 0,22797868 ! actin filament organization GO:0007015 167 72 0,000 0,21948664 0,22788179 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,21948664 0,22778499 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,21948664 0,22768826 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,21948664 0,22759162 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,21948664 0,22749506 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,21948664 0,22739858 ! humoral immune response GO:0006959 115 73 0,000 0,22217108 0,23008222 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,22217108 0,22998473 ! regulation of immune effector process GO:0002697 156 73 0,000 0,22217108 0,22988732 ! acute inflammatory response GO:0002526 118 74 0,000 0,22484637 0,23255702 ! amino acid transport GO:0006865 148 74 0,000 0,22484637 0,2324586 ! organelle localization GO:0051640 155 74 0,000 0,22484637 0,23236027 ! transition metal ion transport GO:0000041 143 75 0,000 0,22751253 0,23501612 ! reproductive structure development GO:0048608 131 75 0,000 0,22751253 0,23491679 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,22751253 0,23481754 ! eye development GO:0001654 155 75 0,000 0,22751253 0,23471838 ! rhythmic process GO:0048511 142 75 0,000 0,22751253 0,2346193 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,2301696 0,23725921 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,2301696 0,23715914 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,2301696 0,23705916 ! regulation of blood pressure GO:0008217 134 76 0,000 0,2301696 0,23695926 ! amine catabolic process GO:0009310 136 77 0,000 0,2328176 0,23958441 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,2328176 0,23948353 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,2328176 0,23938274 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,2328176 0,23928203 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,23545657 0,24189251 ! antigen processing and presentation GO:0019882 117 78 0,000 0,23545657 0,24179083 ! fertilization GO:0009566 99 78 0,000 0,23545657 0,24168924 ! blood coagulation GO:0007596 151 79 0,000 0,23808653 0,24428618 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,23808653 0,24418362 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,23808653 0,24408116 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,23808653 0,24397877 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,23808653 0,24387647 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,23808653 0,24377426 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,24070752 0,24635462 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,24070752 0,24625145 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,24070752 0,24614838 ! muscle cell differentiation GO:0042692 178 81 0,000 0,24331957 0,24871536 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,24592271 0,25127109 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,24851696 0,25381561 ! exocytosis GO:0006887 153 83 0,000 0,24851696 0,25370954 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,24851696 0,25360356 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,24851696 0,25349767 ! inorganic anion transport GO:0015698 156 83 0,000 0,24851696 0,25339187 ! response to nutrient GO:0007584 135 84 0,000 0,25110236 0,25592118 ! digestion GO:0007586 130 84 0,000 0,25110236 0,25581446 ! regulation of ligase activity GO:0051340 147 84 0,000 0,25110236 0,25570782 ! hemostasis GO:0007599 165 85 0,000 0,25367894 0,25822402 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,25367894 0,25811647 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,25367894 0,25800901 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,25367894 0,25790164 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,25367894 0,25779436 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,25624673 0,26029553 ! regulation of lyase activity GO:0051339 169 86 0,000 0,25624673 0,26018735 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,25880575 0,26267655 ! alcohol catabolic process GO:0046164 142 87 0,000 0,25880575 0,26256746 ! nucleosome assembly GO:0006334 126 87 0,000 0,25880575 0,26245847 ! cellular respiration GO:0045333 143 88 0,000 0,26135604 0,26493478 ! amine biosynthetic process GO:0009309 146 88 0,000 0,26135604 0,26482489 ! sensory perception of smell GO:0007608 117 88 0,000 0,26135604 0,2647151 ! chromatin assembly GO:0031497 128 88 0,000 0,26135604 0,26460539 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,26135604 0,26449578 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,26389763 0,26695732 ! tube morphogenesis GO:0035239 194 89 0,000 0,26389763 0,26684682 ! cellular defense response GO:0006968 123 89 0,000 0,26389763 0,26673642 ! regulation of neurological system process GO:0031644 175 89 0,000 0,26389763 0,2666261 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,26643055 0,26907393 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,26643055 0,26896274 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,26895482 0,27139885 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,26895482 0,2712868 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,27147047 0,27371125 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,27397754 0,27612505 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,27397754 0,27601119 ! vitamin metabolic process GO:0006766 153 93 0,000 0,27397754 0,27589742 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,27647605 0,27829872 ! female pregnancy GO:0007565 166 94 0,000 0,27647605 0,2781841 ! sterol metabolic process GO:0016125 166 94 0,000 0,27647605 0,27806957 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,27647605 0,27795514 ! regulation of defense response GO:0031347 171 95 0,000 0,27896604 0,28034308 ! nucleosome organization GO:0034728 143 95 0,000 0,27896604 0,28022781 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,27896604 0,28011263 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,27896604 0,27999755 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,27896604 0,27988256 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,27896604 0,27976766 ! sex differentiation GO:0007548 171 96 0,000 0,28144752 0,28214046 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,28392054 0,28450282 ! forebrain development GO:0030900 210 98 0,000 0,28638511 0,28685478 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,28638511 0,28673722 ! mRNA transport GO:0051028 185 100 0,000 0,29128904 0,2915277 ! positive regulation of immune response GO:0050778 175 100 0,000 0,29128904 0,29140832 ! hormone metabolic process GO:0042445 171 100 0,000 0,29128904 0,29128904