pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6554-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! phospholipid dephosphorylation GO:0046839 12 5 3,000 3,586E-10 8,761E-07 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 1,073E-09 1,311E-06 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 4,000 1,229E-09 1,001E-06 ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 2,499E-09 1,526E-06 ! negative regulation of cell migration GO:0030336 122 46 5,000 4,894E-09 2,391E-06 ! regulation of lipid kinase activity GO:0043550 17 8 3,000 4,987E-09 2,03E-06 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 3,000 4,987E-09 1,74E-06 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 4,987E-09 1,523E-06 ! negative regulation of cell motion GO:0051271 142 55 5,000 1,482E-08 4,024E-06 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 1,489E-08 3,638E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 1,847E-08 4,102E-06 ! chloride transport GO:0006821 102 57 5,000 1,847E-08 3,76E-06 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 3,000 2,335E-08 4,388E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! endothelial cell migration GO:0043542 31 17 3,000 1,661E-07 2,899E-05 ! cardiac muscle tissue development GO:0048738 34 17 3,000 1,661E-07 2,705E-05 ! inorganic anion transport GO:0015698 156 83 5,000 1,805E-07 2,757E-05 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 2,273E-07 3,266E-05 ! inositol metabolic process GO:0006020 33 19 3,000 2,693E-07 3,655E-05 ! nuclear migration GO:0007097 13 6 2,000 4,978E-07 6,4E-05 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 4,978E-07 6,08E-05 GO:0031272|regulation of pseudopodium assembly, ! regulation of cell-matrix adhesion GO:0001952 81 23 3,000 6,097E-07 7,092E-05 GO:0010810|regulation of cell-substrate adhesion, ! response to UV GO:0009411 120 55 4,000 6,321E-07 7,019E-05 ! positive regulation of cell migration GO:0030335 137 58 4,000 8,267E-07 8,781E-05 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 3,000 8,67E-07 8,825E-05 ! lipid modification GO:0030258 112 60 4,000 9,808E-07 9,584E-05 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 1,022E-06 9,606E-05 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 1,197E-06 1,083E-04 ! protein amino acid autophosphorylation GO:0046777 157 64 4,000 1,356E-06 1,184E-04 ! male meiosis GO:0007140 9 8 2,000 1,388E-06 1,169E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 1,388E-06 1,13E-04 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 1,394E-06 1,098E-04 ! positive regulation of cell motion GO:0051272 157 65 4,000 1,466E-06 1,119E-04 ! negative regulation of protein kinase cascade GO:0010741 72 30 3,000 1,857E-06 1,375E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 2,077E-06 1,492E-04 ! macrophage differentiation GO:0030225 15 9 2,000 2,077E-06 1,45E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 2,000 2,961E-06 2,009E-04 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 3,000 3,114E-06 2,056E-04 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 3,41E-06 2,192E-04 ! nucleus localization GO:0051647 22 11 2,000 4,063E-06 2,545E-04 ! negative regulation of cell adhesion GO:0007162 94 37 3,000 4,405E-06 2,69E-04 ! regulation of protein stability GO:0031647 77 38 3,000 4,912E-06 2,927E-04 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 4,912E-06 2,857E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 5,405E-06 3,071E-04 ! mammary gland development GO:0030879 93 40 3,000 6,054E-06 3,361E-04 ! double-strand break repair via homologous recombination GO:0000724 19 13 2,000 7,011E-06 3,806E-04 GO:0000725|recombinational repair, ! response to X-ray GO:0010165 28 13 2,000 7,011E-06 3,724E-04 ! regulation of cell adhesion GO:0030155 241 92 4,000 8,194E-06 4,259E-04 ! response to gamma radiation GO:0010332 30 14 2,000 8,905E-06 4,532E-04 ! double-strand break repair GO:0006302 85 44 3,000 8,911E-06 4,443E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 9,758E-06 4,768E-04 ! polyol metabolic process GO:0019751 77 45 3,000 9,758E-06 4,674E-04 ! response to insulin stimulus GO:0032868 98 47 3,000 1,163E-05 5,463E-04 ! filopodium assembly GO:0046847 42 17 2,000 1,653E-05 7,618E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 1,979E-05 8,953E-04 ! microspike assembly GO:0030035 46 18 2,000 1,979E-05 8,791E-04 ! regulation of DNA replication GO:0006275 105 56 3,000 2,346E-05 1,024E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 3,205E-05 1,374E-03 ! DNA damage response, signal transduction GO:0042770 136 62 3,000 3,515E-05 1,481E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 2,000 3,703E-05 1,533E-03 ! cell aging GO:0007569 48 22 2,000 3,703E-05 1,508E-03 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 3,986E-05 1,596E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 4,501E-05 1,773E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 4,846E-05 1,879E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 4,846E-05 1,85E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 5,495E-05 2,065E-03 ! vasculogenesis GO:0001570 49 25 2,000 5,495E-05 2,034E-03 ! negative regulation of DNA replication GO:0008156 45 25 2,000 5,495E-05 2,004E-03 ! interaction with host GO:0051701 66 25 2,000 5,495E-05 1,974E-03 ! protein tetramerization GO:0051262 57 25 2,000 5,495E-05 1,946E-03 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 6,198E-05 2,163E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 6,958E-05 2,394E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 7,776E-05 2,639E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 8,594E-05 2,876E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 8,594E-05 2,837E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 8,594E-05 2,799E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 8,594E-05 2,762E-03 ! virus-infected cell apoptosis GO:0006926 7 5 1,000 8,594E-05 2,727E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 8,594E-05 2,692E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 8,594E-05 2,658E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 8,594E-05 2,624E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 8,594E-05 2,592E-03 ! inner ear receptor stereocilium organization GO:0060122 12 5 1,000 8,594E-05 2,56E-03 GO:0060119|inner ear receptor cell development, ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 8,655E-05 2,548E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 9,596E-05 2,791E-03 ! meiosis GO:0007126 143 81 3,000 1,004E-04 2,886E-03 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 144 82 3,000 1,053E-04 2,992E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 1,06E-04 2,977E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,167E-04 3,241E-03 ! cellular response to hormone stimulus GO:0032870 182 85 3,000 1,211E-04 3,325E-03 ! response to ionizing radiation GO:0010212 74 33 2,000 1,281E-04 3,478E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 1,287E-04 3,454E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! response to UV-C GO:0010225 14 6 1,000 1,287E-04 3,416E-03 ! base conversion or substitution editing GO:0016553 6 6 1,000 1,287E-04 3,38E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 1,287E-04 3,344E-03 ! regulation of cell cycle process GO:0010564 161 90 3,000 1,511E-04 3,886E-03 ! negative regulation of DNA metabolic process GO:0051053 65 35 2,000 1,53E-04 3,895E-03 ! gland development GO:0048732 220 91 3,000 1,577E-04 3,972E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 1,715E-04 4,276E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 1,798E-04 4,436E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 1,798E-04 4,392E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,798E-04 4,348E-03 ! mRNA stabilization GO:0048255 18 7 1,000 1,798E-04 4,306E-03 GO:0043489|RNA stabilization, ! male sex determination GO:0030238 15 7 1,000 1,798E-04 4,264E-03 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 1,798E-04 4,223E-03 ! centrosome duplication GO:0051298 14 7 1,000 1,798E-04 4,183E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 1,798E-04 4,143E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 1,798E-04 4,105E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 1,798E-04 4,067E-03 ! glycogen metabolic process GO:0005977 63 38 2,000 1,96E-04 4,393E-03 ! regulation of DNA metabolic process GO:0051052 188 97 3,000 2,017E-04 4,48E-03 ! leukocyte differentiation GO:0002521 232 98 3,000 2,098E-04 4,618E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 2,098E-04 4,577E-03 ! glucan metabolic process GO:0044042 64 39 2,000 2,119E-04 4,581E-03 GO:0006073|cellular glucan metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 2,392E-04 5,127E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 2,392E-04 5,082E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 2,392E-04 5,038E-03 ! ER overload response GO:0006983 13 8 1,000 2,392E-04 4,995E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 2,392E-04 4,953E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,392E-04 4,911E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 2,392E-04 4,87E-03 ! response to tumor cell GO:0002347 16 8 1,000 2,392E-04 4,83E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 2,392E-04 4,791E-03 ! blastocyst growth GO:0001832 19 8 1,000 2,392E-04 4,752E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 2,392E-04 4,713E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 2,461E-04 4,809E-03 ! energy reserve metabolic process GO:0006112 76 44 2,000 3,038E-04 5,89E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 3,07E-04 5,905E-03 ! induction of positive chemotaxis GO:0050930 17 9 1,000 3,07E-04 5,859E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 3,07E-04 5,814E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 3,07E-04 5,769E-03 ! S phase GO:0051320 10 9 1,000 3,07E-04 5,725E-03 GO:0000084|S phase of mitotic cell cycle, ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 3,467E-04 6,416E-03 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 3,467E-04 6,368E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 3,83E-04 6,983E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 3,83E-04 6,931E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 3,83E-04 6,88E-03 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 3,83E-04 6,83E-03 ! lung alveolus development GO:0048286 26 10 1,000 3,83E-04 6,78E-03 ! pathogenesis GO:0009405 17 10 1,000 3,83E-04 6,731E-03 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 3,83E-04 6,683E-03 ! multicellular organism growth GO:0035264 19 10 1,000 3,83E-04 6,636E-03 ! motor axon guidance GO:0008045 22 10 1,000 3,83E-04 6,589E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 3,83E-04 6,543E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 3,83E-04 6,498E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 3,83E-04 6,453E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 3,83E-04 6,409E-03 ! positive regulation of cell cycle GO:0045787 96 48 2,000 3,933E-04 6,537E-03 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 4,181E-04 6,901E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 4,672E-04 7,66E-03 ! blood vessel remodeling GO:0001974 30 11 1,000 4,672E-04 7,609E-03 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 4,672E-04 7,559E-03 ! regulation of intracellular pH GO:0051453 21 11 1,000 4,672E-04 7,509E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 4,672E-04 7,46E-03 ! oocyte development GO:0048599 20 11 1,000 4,672E-04 7,412E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 4,672E-04 7,364E-03 ! regulation of cell projection organization GO:0031344 135 51 2,000 4,705E-04 7,369E-03 ! Notch signaling pathway GO:0007219 111 52 2,000 4,983E-04 7,753E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 5,27E-04 8,149E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 5,596E-04 8,598E-03 ! virus-host interaction GO:0019048 30 12 1,000 5,596E-04 8,544E-03 ! regulation of B cell proliferation GO:0030888 22 12 1,000 5,596E-04 8,491E-03 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 5,596E-04 8,438E-03 GO:0050927|positive regulation of positive chemotaxis, ! entry into host cell GO:0030260 34 12 1,000 5,596E-04 8,387E-03 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of leukocyte migration GO:0002685 29 12 1,000 5,596E-04 8,336E-03 ! oocyte differentiation GO:0009994 21 12 1,000 5,596E-04 8,285E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 5,596E-04 8,235E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 5,596E-04 8,186E-03 ! localization within membrane GO:0051668 26 12 1,000 5,596E-04 8,137E-03 ! nucleotide-excision repair GO:0006289 91 57 2,000 6,527E-04 9,435E-03 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 6,6E-04 9,485E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 6,6E-04 9,43E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 6,6E-04 9,375E-03 ! regulation of mRNA stability GO:0043488 32 13 1,000 6,6E-04 9,321E-03 ! cellular polysaccharide metabolic process GO:0044264 93 58 2,000 6,868E-04 9,643E-03 ! aging GO:0007568 112 58 2,000 6,868E-04 9,588E-03 ! establishment of organelle localization GO:0051656 122 59 2,000 7,221E-04 0,01002269 ! regulation of S phase GO:0033261 26 14 1,000 7,686E-04 0,01060786 ! regulation of cellular pH GO:0030641 27 14 1,000 7,686E-04 0,01054827 ! regulation of RNA stability GO:0043487 33 14 1,000 7,686E-04 0,01048934 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 7,686E-04 0,01043106 ! viral reproductive process GO:0022415 132 62 2,000 8,346E-04 0,01126545 ! regulation of protein complex assembly GO:0043254 132 63 2,000 8,745E-04 0,0117386 ! regulation of mitosis GO:0007088 112 63 2,000 8,745E-04 0,01167445 GO:0051783|regulation of nuclear division, ! negative regulation of bone remodeling GO:0046851 34 15 1,000 8,851E-04 0,01175151 ! regulation of mRNA processing GO:0050684 26 15 1,000 8,851E-04 0,01168798 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 8,851E-04 0,01162514 ! G1/S transition checkpoint GO:0031575 37 15 1,000 8,851E-04 0,01156298 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 8,851E-04 0,01150147 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 1,01E-03 0,0130498 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 1,01E-03 0,01298112 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,01E-03 0,01291316 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 1,01E-03 0,0128459 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 1,01E-03 0,01277934 ! negative regulation of cell growth GO:0030308 142 67 2,000 1,046E-03 0,01317168 ! myeloid cell differentiation GO:0030099 126 67 2,000 1,046E-03 0,01310414 ! viral reproduction GO:0016032 142 68 2,000 1,092E-03 0,01360987 ! cell projection assembly GO:0030031 138 68 2,000 1,092E-03 0,01354079 ! negative regulation of cell size GO:0045792 144 69 2,000 1,139E-03 0,01405471 ! lung development GO:0030324 165 69 2,000 1,139E-03 0,01398408 ! gene silencing by RNA GO:0031047 38 17 1,000 1,142E-03 0,01394942 ! auditory receptor cell differentiation GO:0042491 36 17 1,000 1,142E-03 0,01388002 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,142E-03 0,01381131 ! centrosome cycle GO:0007098 26 18 1,000 1,282E-03 0,01543141 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 1,282E-03 0,01535577 ! respiratory tube development GO:0030323 171 72 2,000 1,288E-03 0,01535343 ! respiratory system development GO:0060541 175 74 2,000 1,394E-03 0,01653616 ! organelle localization GO:0051640 155 74 2,000 1,394E-03 0,01645628 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 1,43E-03 0,01679988 ! neuromuscular junction development GO:0007528 43 19 1,000 1,43E-03 0,0167195 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 1,43E-03 0,01663988 ! regulation of catabolic process GO:0009894 173 77 2,000 1,563E-03 0,01810155 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 1,586E-03 0,01827908 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 1,586E-03 0,01819327 GO:0010675|regulation of cellular carbohydrate metabolic process, ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 1,586E-03 0,01810825 ! cellular response to unfolded protein GO:0034620 35 20 1,000 1,586E-03 0,01802403 GO:0030968|endoplasmic reticulum unfolded protein response, ! negative regulation of T cell activation GO:0050868 41 20 1,000 1,586E-03 0,01794058 ! protein oligomerization GO:0051259 149 79 2,000 1,683E-03 0,01894659 ! lipid phosphorylation GO:0046834 43 21 1,000 1,75E-03 0,01960934 ! ribosomal small subunit biogenesis GO:0042274 25 21 1,000 1,75E-03 0,0195198 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 1,75E-03 0,01943107 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 1,75E-03 0,01934315 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 1,921E-03 0,02114087 ! cellular response to starvation GO:0009267 37 22 1,000 1,921E-03 0,02104607 ! positive regulation of locomotion GO:0040017 44 22 1,000 1,921E-03 0,02095211 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 42 22 1,000 1,921E-03 0,02085899 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 1,921E-03 0,0207667 ! inner ear receptor cell differentiation GO:0060113 42 22 1,000 1,921E-03 0,02067521 ! response to nutrient GO:0007584 135 84 2,000 2,006E-03 0,02149717 ! negative regulation of growth GO:0045926 168 85 2,000 2,075E-03 0,02213907 ! positive regulation of DNA replication GO:0045740 44 23 1,000 2,1E-03 0,02230593 ! regulation of chemotaxis GO:0050920 45 23 1,000 2,1E-03 0,02220937 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 2,1E-03 0,02211364 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 2,287E-03 0,02397425 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 2,287E-03 0,02387179 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 2,287E-03 0,02377021 ! mechanoreceptor differentiation GO:0042490 48 24 1,000 2,287E-03 0,02366949 ! sex determination GO:0007530 48 24 1,000 2,287E-03 0,02356962 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 2,287E-03 0,02347059 ! oogenesis GO:0048477 44 24 1,000 2,287E-03 0,02337238 ! response to unfolded protein GO:0006986 139 90 2,000 2,442E-03 0,02485951 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 2,481E-03 0,0251455 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 2,481E-03 0,02504159 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 2,481E-03 0,02493854 ! regulation of behavior GO:0050795 48 25 1,000 2,481E-03 0,02483633 ! myelination GO:0042552 50 26 1,000 2,682E-03 0,0267447 ! initiation of viral infection GO:0019059 60 26 1,000 2,682E-03 0,02663598 ! microtubule organizing center organization GO:0031023 42 26 1,000 2,682E-03 0,02652814 GO:0051297|centrosome organization, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 2,682E-03 0,02642118 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of cell development GO:0010721 83 26 1,000 2,682E-03 0,02631507 GO:0050768|negative regulation of neurogenesis, ! blastocyst development GO:0001824 50 26 1,000 2,682E-03 0,02620981 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 2,891E-03 0,02813964 ! mitochondrial membrane organization GO:0007006 60 27 1,000 2,891E-03 0,02802797 ! response to starvation GO:0042594 47 27 1,000 2,891E-03 0,02791719 ! cellular response to nutrient levels GO:0031669 45 27 1,000 2,891E-03 0,02780728 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 2,891E-03 0,02769823 ! response to protein stimulus GO:0051789 158 96 2,000 2,932E-03 0,02798462 ! neuron fate commitment GO:0048663 52 28 1,000 3,108E-03 0,02953987 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 3,108E-03 0,02942537 ! base-excision repair GO:0006284 41 28 1,000 3,108E-03 0,02931176 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 3,331E-03 0,03130168 ! translational initiation GO:0006413 66 29 1,000 3,331E-03 0,03118175 ! response to organic cyclic substance GO:0014070 58 29 1,000 3,331E-03 0,03106273 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 3,331E-03 0,03094462 ! neuromuscular process controlling balance GO:0050885 67 29 1,000 3,331E-03 0,03082741 ! tissue homeostasis GO:0001894 50 30 1,000 3,562E-03 0,03284154 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 1,000 3,562E-03 0,03271807 ! ensheathment of neurons GO:0007272 64 31 1,000 3,801E-03 0,0347766 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 3,801E-03 0,03464684 ! peripheral nervous system development GO:0007422 68 32 1,000 4,046E-03 0,03674857 ! gene silencing GO:0016458 71 32 1,000 4,046E-03 0,03661246 ! regulation of pH GO:0006885 56 33 1,000 4,299E-03 0,03875622 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 4,299E-03 0,03861373 ! negative regulation of protein transport GO:0051224 74 33 1,000 4,299E-03 0,03847229 ! inner ear morphogenesis GO:0042472 51 34 1,000 4,559E-03 0,04064948 ! DNA damage checkpoint GO:0000077 78 35 1,000 4,826E-03 0,04287391 ! calcium-mediated signaling GO:0019722 67 35 1,000 4,826E-03 0,04271857 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 5,1E-03 0,04498171 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 5,381E-03 0,04729019 ! tissue remodeling GO:0048771 78 37 1,000 5,381E-03 0,04712069 ! female gonad development GO:0008585 71 37 1,000 5,381E-03 0,04695241 ! negative regulation of cell activation GO:0050866 69 37 1,000 5,381E-03 0,04678532 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 5,669E-03 0,04911505 ! DNA integrity checkpoint GO:0031570 82 38 1,000 5,669E-03 0,0489415 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 5,964E-03 0,05130682 ! carbohydrate homeostasis GO:0033500 59 39 1,000 5,964E-03 0,0511268 GO:0042593|glucose homeostasis, ! erythrocyte homeostasis GO:0034101 75 39 1,000 5,964E-03 0,05094803 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 5,964E-03 0,05077051 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! development of primary female sexual characteristics GO:0046545 80 40 1,000 6,266E-03 0,05315504 GO:0046660|female sex differentiation, ! mismatch repair GO:0006298 58 40 1,000 6,266E-03 0,05297111 ! regulation of action potential in neuron GO:0019228 80 40 1,000 6,266E-03 0,05278845 ! Rho protein signal transduction GO:0007266 88 40 1,000 6,266E-03 0,05260705 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 6,575E-03 0,05500986 ! RNA modification GO:0009451 64 41 1,000 6,575E-03 0,05482212 ! ear morphogenesis GO:0042471 64 42 1,000 6,891E-03 0,05725756 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 6,891E-03 0,05706347 ! T cell differentiation GO:0030217 93 42 1,000 6,891E-03 0,05687069 ! regulation of T cell differentiation GO:0045580 78 42 1,000 6,891E-03 0,0566792 ! cytokinesis GO:0000910 84 42 1,000 6,891E-03 0,056489 ! regulation of T cell proliferation GO:0042129 80 43 1,000 7,213E-03 0,05893336 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 7,542E-03 0,06141612 ! receptor-mediated endocytosis GO:0006898 98 45 1,000 7,878E-03 0,06393655 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 7,878E-03 0,06372484 ! B cell differentiation GO:0030183 124 45 1,000 7,878E-03 0,06351453 ! female gamete generation GO:0007292 71 45 1,000 7,878E-03 0,0633056 ! developmental growth GO:0048589 88 45 1,000 7,878E-03 0,06309804 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 8,22E-03 0,06562475 ! mitochondrial transport GO:0006839 94 48 1,000 8,924E-03 0,07101604 ! vascular process in circulatory system GO:0003018 85 48 1,000 8,924E-03 0,07078547 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 9,286E-03 0,07341813 ! regulation of action potential GO:0001508 102 50 1,000 9,655E-03 0,07608479 ! activation of caspase activity GO:0006919 95 50 1,000 9,655E-03 0,07584015 ! viral infectious cycle GO:0019058 104 51 1,000 0,0100295 0,07853228 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,0100295 0,07828138 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,01041075 0,08099829 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,01041075 0,08074115 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,01041075 0,08048564 ! positive regulation of growth GO:0045927 96 53 1,000 0,01079835 0,0832188 ! inner ear development GO:0048839 89 53 1,000 0,01079835 0,08295711 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01079835 0,08269706 ! synapse organization GO:0050808 102 53 1,000 0,01079835 0,08243863 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,01119225 0,08517965 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,01119225 0,08491512 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 1,000 0,01119225 0,08465222 ! regulation of cell shape GO:0008360 142 54 1,000 0,01119225 0,08439095 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,01159242 0,08713934 ! cell maturation GO:0048469 107 55 1,000 0,01159242 0,08687204 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,01199882 0,08964256 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,01199882 0,08936926 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,01241141 0,0921613 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,01241141 0,09188202 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,01241141 0,09160443 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,01241141 0,09132851 ! heart morphogenesis GO:0003007 105 57 1,000 0,01241141 0,09105425 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,01241141 0,09078164 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,01283014 0,09356429 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,01283014 0,09328583 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,01412285 0,10238018 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,01456579 0,10527877 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01468424 0,10582181 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01468424 0,10551057 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01468424 0,10520115 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01468424 0,10489355 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01468424 0,10458774 ! neuron fate determination GO:0048664 7 5 0,000 0,01468424 0,1042837 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01468424 0,10398143 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01468424 0,10368091 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01468424 0,10338211 ! polyol transport GO:0015791 12 5 0,000 0,01468424 0,10308504 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01468424 0,10278967 ! response to superoxide GO:0000303 10 5 0,000 0,01468424 0,10249598 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01468424 0,10220397 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01468424 0,10191362 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01468424 0,10162491 ! female meiosis GO:0007143 10 5 0,000 0,01468424 0,10133783 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01468424 0,10105238 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01468424 0,10076852 ! hypothalamus development GO:0021854 9 5 0,000 0,01468424 0,10048626 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01468424 0,10020557 ! cobalt ion transport GO:0006824 11 5 0,000 0,01468424 0,09992644 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01468424 0,09964887 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01468424 0,09937284 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01468424 0,09909832 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01468424 0,09882533 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01468424 0,09855383 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01468424 0,09828382 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01468424 0,09801528 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01468424 0,09774821 ! transposition GO:0032196 9 5 0,000 0,01468424 0,09748259 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01468424 0,09721841 ! negative chemotaxis GO:0050919 16 5 0,000 0,01468424 0,09695566 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01468424 0,09669432 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01468424 0,09643439 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01468424 0,09617585 ! behavioral response to pain GO:0048266 10 5 0,000 0,01468424 0,0959187 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01468424 0,09566292 ! Notch receptor processing GO:0007220 11 5 0,000 0,01468424 0,09540849 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01468424 0,09515542 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01468424 0,09490369 ! micturition GO:0060073 9 5 0,000 0,01468424 0,09465328 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01468424 0,09440419 ! copulation GO:0007620 9 5 0,000 0,01468424 0,09415641 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01468424 0,09390993 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01468424 0,09366473 ! bioluminescence GO:0008218 9 5 0,000 0,01468424 0,09342082 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01468424 0,09317816 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01468424 0,09293677 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01468424 0,09269662 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01468424 0,09245772 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01468424 0,09222003 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01468424 0,09198357 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01468424 0,09174832 ! grooming behavior GO:0007625 6 5 0,000 0,01468424 0,09151427 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01468424 0,09128141 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01468424 0,09104973 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01468424 0,09081922 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01468424 0,09058988 ! response to protozoan GO:0001562 13 5 0,000 0,01468424 0,0903617 ! lymph vessel development GO:0001945 10 5 0,000 0,01468424 0,09013466 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01468424 0,08990876 ! endochondral ossification GO:0001958 17 5 0,000 0,01468424 0,08968398 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01468424 0,08946033 ! single strand break repair GO:0000012 8 5 0,000 0,01468424 0,08923779 ! parathyroid gland development GO:0060017 14 5 0,000 0,01468424 0,08901636 ! anagen GO:0042640 7 5 0,000 0,01468424 0,08879602 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01468424 0,08857677 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01468424 0,0883586 ! cytokine secretion GO:0050663 15 5 0,000 0,01468424 0,08814151 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01468424 0,08792547 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01468424 0,0877105 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01468424 0,08749657 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01468424 0,08728368 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01468424 0,08707183 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01468424 0,086861 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01468424 0,08665119 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01468424 0,08644239 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01468424 0,0862346 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01468424 0,0860278 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01468424 0,08582199 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01468424 0,08561717 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01468424 0,08541332 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01468424 0,08521044 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01468424 0,08500852 ! microvillus organization GO:0032528 8 5 0,000 0,01468424 0,08480755 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01468424 0,08460753 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01468424 0,08440846 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01468424 0,08421031 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01468424 0,0840131 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01468424 0,08381681 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01468424 0,08362143 ! polyol catabolic process GO:0046174 9 5 0,000 0,01468424 0,08342696 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01468424 0,0832334 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01468424 0,08304073 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01468424 0,08284895 ! muscle cell migration GO:0014812 8 5 0,000 0,01468424 0,08265805 ! mitochondrial fission GO:0000266 8 5 0,000 0,01468424 0,08246803 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01468424 0,08227888 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01468424 0,0820906 ! mRNA transcription GO:0009299 10 5 0,000 0,01468424 0,08190318 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01468424 0,08171661 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01468424 0,08153089 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01468424 0,08134602 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01468424 0,08116198 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01468424 0,08097877 ! monocyte activation GO:0042117 10 5 0,000 0,01468424 0,08079638 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01468424 0,08061482 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01468424 0,08043407 ! response to food GO:0032094 6 5 0,000 0,01468424 0,08025412 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01468424 0,08007499 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01468424 0,07989664 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01468424 0,0797191 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01468424 0,07954234 ! forebrain neuron development GO:0021884 13 5 0,000 0,01468424 0,07936636 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01468424 0,07919116 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01468424 0,07901673 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01468424 0,07884306 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01468424 0,07867016 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01468424 0,07849802 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01468424 0,07832662 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01468424 0,07815598 ! lipid glycosylation GO:0030259 7 5 0,000 0,01468424 0,07798607 ! nucleobase transport GO:0015851 6 5 0,000 0,01468424 0,07781691 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01468424 0,07764847 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01468424 0,07748076 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01468424 0,07731378 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01468424 0,07714751 ! basic amino acid transport GO:0015802 12 5 0,000 0,01468424 0,07698196 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01468424 0,07681712 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01468424 0,07665298 ! actin nucleation GO:0045010 11 5 0,000 0,01468424 0,07648954 ! depurination GO:0045007 5 5 0,000 0,01468424 0,07632679 ! depyrimidination GO:0045008 10 5 0,000 0,01468424 0,07616474 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01468424 0,07600338 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01468424 0,07584269 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01468424 0,07568269 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01468424 0,07552335 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01468424 0,07536469 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01468424 0,07520669 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01468424 0,07504936 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01468424 0,07489268 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01468424 0,07473665 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01468424 0,07458128 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01468424 0,07442654 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01468424 0,07427245 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01468424 0,07411899 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01468424 0,07396617 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01468424 0,07381398 ! response to arsenic GO:0046685 11 5 0,000 0,01468424 0,07366241 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01468424 0,07351146 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01468424 0,07336113 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01468424 0,07321142 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01468424 0,07306231 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01468424 0,07291381 ! response to mercury ion GO:0046689 8 5 0,000 0,01468424 0,07276591 ! response to cadmium ion GO:0046686 7 5 0,000 0,01468424 0,07261861 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01468424 0,07247191 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01468424 0,07232579 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01468424 0,07218027 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01468424 0,07203533 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01468424 0,07189097 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01468424 0,07174719 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01468424 0,07160398 ! decidualization GO:0046697 11 5 0,000 0,01468424 0,07146134 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01468424 0,07131927 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01468424 0,07117776 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01468424 0,07103682 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01468424 0,07089643 ! embryonic cleavage GO:0040016 6 5 0,000 0,01468424 0,07075659 ! peroxisome fission GO:0016559 5 5 0,000 0,01468424 0,07061731 ! histone demethylation GO:0016577 13 5 0,000 0,01468424 0,07047857 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01468424 0,07034038 ! mitotic recombination GO:0006312 9 5 0,000 0,01468424 0,07020273 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01468424 0,07006561 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01468424 0,06992903 ! metaphase plate congression GO:0051310 7 5 0,000 0,01468424 0,06979298 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01468424 0,06965746 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01468424 0,06952247 ! enteric nervous system development GO:0048484 8 5 0,000 0,01468424 0,069388 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01468424 0,06925404 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01468424 0,0691206 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01468424 0,06898768 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01468424 0,06885527 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01468424 0,06872336 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01468424 0,06859196 ! B cell homeostasis GO:0001782 13 5 0,000 0,01468424 0,06846106 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01468424 0,06833065 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01468424 0,06820075 ! metaphase GO:0051323 11 5 0,000 0,01468424 0,06807133 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01468424 0,06794241 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01468424 0,06781398 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01468424 0,06768603 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01468424 0,06755856 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01468424 0,06743157 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01468424 0,06730505 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01468424 0,06717901 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01468424 0,06705345 ! response to redox state GO:0051775 6 5 0,000 0,01468424 0,06692835 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01468424 0,06680371 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01468424 0,06667954 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01468424 0,06655583 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01468424 0,06643258 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01468424 0,06630978 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01468424 0,06618744 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01468424 0,06606555 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01468424 0,06594411 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01468424 0,06582311 ! striatum development GO:0021756 14 5 0,000 0,01468424 0,06570255 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01468424 0,06558244 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01468424 0,06546276 ! glial cell migration GO:0008347 10 5 0,000 0,01468424 0,06534352 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01468424 0,06522472 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01468424 0,06510634 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01468424 0,06498839 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01468424 0,06487087 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01468424 0,06475378 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01468424 0,06463711 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01468424 0,06452085 ! neuroprotection GO:0043526 8 5 0,000 0,01468424 0,06440502 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01468424 0,06428959 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01468424 0,06417459 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01468424 0,06405999 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01468424 0,0639458 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01468424 0,06383202 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01468424 0,06371864 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01468424 0,06360566 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01468424 0,06349309 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01468424 0,06338091 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01468424 0,06326912 ! spindle assembly GO:0051225 6 5 0,000 0,01468424 0,06315773 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01468424 0,06304674 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01468424 0,06293613 ! protein palmitoylation GO:0018345 12 5 0,000 0,01468424 0,06282591 ! drug metabolic process GO:0017144 7 5 0,000 0,01468424 0,06271607 ! stem cell division GO:0017145 11 5 0,000 0,01468424 0,06260662 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01468424 0,06249755 ! organ regeneration GO:0031100 7 5 0,000 0,01468424 0,06238886 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01468424 0,06228054 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01468424 0,06217261 ! ear development GO:0043583 114 66 1,000 0,01639671 0,06930306 ! gonad development GO:0008406 115 66 1,000 0,01639671 0,06918336 ! activation of MAPK activity GO:0000187 124 67 1,000 0,01686904 0,07105357 ! regulation of lipase activity GO:0060191 137 68 1,000 0,01734714 0,07294158 ! adaptive immune response GO:0002250 126 68 1,000 0,01734714 0,07281625 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01759535 0,07373148 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01759535 0,07360522 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01759535 0,0734794 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01759535 0,07335401 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01759535 0,07322905 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01759535 0,07310451 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01759535 0,07298039 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01759535 0,0728567 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01759535 0,07273342 ! response to oxygen radical GO:0000305 11 6 0,000 0,01759535 0,07261056 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01759535 0,07248811 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01759535 0,07236608 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01759535 0,07224445 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01759535 0,07212324 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01759535 0,07200243 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01759535 0,07188202 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01759535 0,07176202 ! forebrain regionalization GO:0021871 9 6 0,000 0,01759535 0,07164242 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01759535 0,07152321 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01759535 0,0714044 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01759535 0,07128599 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01759535 0,07116796 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01759535 0,07105033 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01759535 0,07093309 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01759535 0,07081623 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01759535 0,07069975 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01759535 0,07058366 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01759535 0,07046795 ! malate metabolic process GO:0006108 13 6 0,000 0,01759535 0,07035262 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01759535 0,07023766 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01759535 0,07012308 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01759535 0,07000888 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01759535 0,06989504 ! protein refolding GO:0042026 15 6 0,000 0,01759535 0,06978157 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01759535 0,06966848 ! opsonization GO:0008228 8 6 0,000 0,01759535 0,06955574 ! mating behavior GO:0007617 7 6 0,000 0,01759535 0,06944338 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01759535 0,06933137 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01759535 0,06921973 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01759535 0,06910844 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01759535 0,06899751 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01759535 0,06888694 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01759535 0,06877672 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01759535 0,06866685 ! toxin metabolic process GO:0009404 11 6 0,000 0,01759535 0,06855734 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01759535 0,06844817 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01759535 0,06833935 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01759535 0,06823087 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01759535 0,06812274 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01759535 0,06801495 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01759535 0,0679075 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01759535 0,06780039 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01759535 0,06769362 ! thymic T cell selection GO:0045061 16 6 0,000 0,01759535 0,06758719 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01759535 0,06748108 ! protein lipoylation GO:0009249 10 6 0,000 0,01759535 0,06737531 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01759535 0,06726987 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01759535 0,06716477 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01759535 0,06705998 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01759535 0,06695553 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01759535 0,0668514 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01759535 0,06674759 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01759535 0,06664411 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01759535 0,06654094 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01759535 0,0664381 ! hyperosmotic response GO:0006972 10 6 0,000 0,01759535 0,06633557 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01759535 0,06623336 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01759535 0,06613146 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01759535 0,06602988 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01759535 0,0659286 ! urea metabolic process GO:0019627 7 6 0,000 0,01759535 0,06582764 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01759535 0,06572699 ! neutrophil activation GO:0042119 7 6 0,000 0,01759535 0,06562664 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01759535 0,0655266 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01759535 0,06542686 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01759535 0,06532743 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01759535 0,0652283 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01759535 0,06512947 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01759535 0,06503094 ! neuron apoptosis GO:0051402 15 6 0,000 0,01759535 0,0649327 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01759535 0,06483477 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01759535 0,06473712 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01759535 0,06463977 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01759535 0,06454272 ! carnitine transport GO:0015879 10 6 0,000 0,01759535 0,06444595 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01759535 0,06434948 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01759535 0,06425329 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01759535 0,06415739 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01759535 0,06406177 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01759535 0,06396644 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01759535 0,0638714 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01759535 0,06377663 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01759535 0,06368215 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01759535 0,06358794 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01759535 0,06349402 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01759535 0,06340037 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01759535 0,063307 ! astrocyte development GO:0014002 16 6 0,000 0,01759535 0,0632139 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01759535 0,06312107 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01759535 0,06302852 ! interaction with symbiont GO:0051702 14 6 0,000 0,01759535 0,06293624 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01759535 0,06284423 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01759535 0,06275248 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01759535 0,06266101 ! response to copper ion GO:0046688 10 6 0,000 0,01759535 0,0625698 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01759535 0,06247885 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01759535 0,06238817 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01759535 0,06229775 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01759535 0,0622076 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01759535 0,0621177 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01759535 0,06202807 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01759535 0,06193869 ! hair follicle maturation GO:0048820 8 6 0,000 0,01759535 0,06184957 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01759535 0,0617607 ! Schwann cell development GO:0014044 15 6 0,000 0,01759535 0,06167209 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01759535 0,06158374 ! response to pheromone GO:0019236 6 6 0,000 0,01759535 0,06149564 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01759535 0,06140779 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01759535 0,06132019 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01759535 0,06123283 ! subpallium development GO:0021544 15 6 0,000 0,01759535 0,06114573 ! neural tube patterning GO:0021532 8 6 0,000 0,01759535 0,06105888 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01759535 0,06097227 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01759535 0,06088591 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01759535 0,06079979 ! G2 phase GO:0051319 16 6 0,000 0,01759535 0,06071391 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01759535 0,06062828 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01759535 0,06054289 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01759535 0,06045774 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01759535 0,06037282 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01759535 0,06028815 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01759535 0,06020371 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01759535 0,06011951 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01759535 0,06003554 ! receptor internalization GO:0031623 11 6 0,000 0,01759535 0,05995181 ! plasminogen activation GO:0031639 9 6 0,000 0,01759535 0,05986831 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01759535 0,05978505 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01759535 0,05970201 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01759535 0,05961921 ! protein deubiquitination GO:0016579 16 6 0,000 0,01759535 0,05953663 ! protein destabilization GO:0031648 9 6 0,000 0,01759535 0,05945429 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01759535 0,05937217 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01759535 0,05929028 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01759535 0,05920861 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01759535 0,05912717 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01759535 0,05904595 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01759535 0,05896495 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01759535 0,05888418 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01759535 0,05880363 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01759535 0,05872329 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01759535 0,05864318 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01759535 0,05856328 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01759535 0,05848361 ! neural plate development GO:0001840 9 6 0,000 0,01759535 0,05840414 ! catecholamine transport GO:0051937 9 6 0,000 0,01759535 0,0583249 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01759535 0,05824587 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01759535 0,05816705 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01759535 0,05808845 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01759535 0,05801005 ! maternal placenta development GO:0001893 12 6 0,000 0,01759535 0,05793187 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01759535 0,0578539 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01759535 0,05777614 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01759535 0,05769859 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01759535 0,05762125 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01759535 0,05754411 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01759535 0,05746718 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01759535 0,05739045 GO:0055081|anion homeostasis, ! negative regulation of protein kinase activity GO:0006469 144 69 1,000 0,01783096 0,05808138 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,01783096 0,05800404 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01783096 0,05792691 ! developmental maturation GO:0021700 128 69 1,000 0,01783096 0,05784998 ! negative regulation of kinase activity GO:0033673 145 70 1,000 0,01832047 0,0593593 ! germ cell development GO:0007281 133 70 1,000 0,01832047 0,05928067 ! cell cycle checkpoint GO:0000075 145 71 1,000 0,01881563 0,06080237 ! B cell activation GO:0042113 179 72 1,000 0,01931641 0,06233818 ! regulation of caspase activity GO:0043281 136 74 1,000 0,02033467 0,06553774 ! negative regulation of transferase activity GO:0051348 155 74 1,000 0,02033467 0,06545139 ! tRNA transcription GO:0009304 17 7 0,000 0,02049795 0,06589012 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02049795 0,06580354 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02049795 0,06571718 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02049795 0,06563105 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02049795 0,06554515 ! sleep GO:0030431 16 7 0,000 0,02049795 0,06545947 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02049795 0,06537401 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02049795 0,06528878 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02049795 0,06520377 ! prostate gland development GO:0030850 14 7 0,000 0,02049795 0,06511898 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02049795 0,06503441 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02049795 0,06495006 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02049795 0,06486593 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02049795 0,06478201 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02049795 0,06469831 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02049795 0,06461483 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02049795 0,06453156 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02049795 0,06444851 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02049795 0,06436567 ! glycolipid transport GO:0046836 11 7 0,000 0,02049795 0,06428305 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02049795 0,06420063 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,02049795 0,06411843 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,02049795 0,06403644 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02049795 0,06395465 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02049795 0,06387308 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02049795 0,06379171 ! pericardium development GO:0060039 16 7 0,000 0,02049795 0,06371055 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02049795 0,0636296 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02049795 0,06354885 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,02049795 0,06346831 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02049795 0,06338797 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,02049795 0,06330783 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02049795 0,0632279 ! lipoprotein transport GO:0042953 14 7 0,000 0,02049795 0,06314816 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02049795 0,06306863 ! rhythmic behavior GO:0007622 17 7 0,000 0,02049795 0,0629893 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02049795 0,06291017 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02049795 0,06283123 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02049795 0,0627525 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02049795 0,06267396 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02049795 0,06259562 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02049795 0,06251747 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02049795 0,06243952 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02049795 0,06236176 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02049795 0,0622842 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02049795 0,06220683 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02049795 0,06212965 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02049795 0,06205266 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02049795 0,06197586 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02049795 0,06189925 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02049795 0,06182283 ! spinal cord patterning GO:0021511 14 7 0,000 0,02049795 0,0617466 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02049795 0,06167056 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02049795 0,0615947 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02049795 0,06151903 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02049795 0,06144355 ! adrenal gland development GO:0030325 17 7 0,000 0,02049795 0,06136825 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02049795 0,06129314 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02049795 0,06121821 ! ovulation GO:0030728 10 7 0,000 0,02049795 0,06114346 ! adenohypophysis development GO:0021984 11 7 0,000 0,02049795 0,0610689 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02049795 0,06099451 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02049795 0,06092031 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02049795 0,06084629 ! microtubule nucleation GO:0007020 21 7 0,000 0,02049795 0,06077244 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02049795 0,06069878 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02049795 0,0606253 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02049795 0,06055199 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02049795 0,06047886 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02049795 0,0604059 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02049795 0,06033313 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02049795 0,06026052 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02049795 0,06018809 ! galactose metabolic process GO:0006012 13 7 0,000 0,02049795 0,06011584 ! vesicle fusion GO:0006906 20 7 0,000 0,02049795 0,06004376 ! response to dietary excess GO:0002021 8 7 0,000 0,02049795 0,05997185 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02049795 0,05990011 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02049795 0,05982855 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02049795 0,05975715 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02049795 0,05968593 ! organ growth GO:0035265 15 7 0,000 0,02049795 0,05961487 ! nucleoside transport GO:0015858 11 7 0,000 0,02049795 0,05954399 ! nucleoside salvage GO:0043174 11 7 0,000 0,02049795 0,05947327 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02049795 0,05940272 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02049795 0,05933234 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02049795 0,05926212 ! parturition GO:0007567 16 7 0,000 0,02049795 0,05919207 ! rRNA modification GO:0000154 14 7 0,000 0,02049795 0,05912219 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02049795 0,05905247 ! spindle checkpoint GO:0031577 16 7 0,000 0,02049795 0,05898291 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02049795 0,05891352 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02049795 0,05884429 ! monocyte differentiation GO:0030224 16 7 0,000 0,02049795 0,05877523 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02049795 0,05870632 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02049795 0,05863758 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02049795 0,058569 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02049795 0,05850058 ! fibrinolysis GO:0042730 11 7 0,000 0,02049795 0,05843232 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02049795 0,05836421 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02049795 0,05829627 ! eating behavior GO:0042755 8 7 0,000 0,02049795 0,05822848 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02049795 0,05816085 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02049795 0,05809338 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02049795 0,05802607 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02049795 0,05795891 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02049795 0,0578919 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02049795 0,05782505 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02049795 0,05775836 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02049795 0,05769181 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02049795 0,05762542 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02049795 0,05755919 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02049795 0,0574931 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02049795 0,05742717 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02049795 0,05736139 ! histone ubiquitination GO:0016574 9 7 0,000 0,02049795 0,05729576 ! regulation of meiosis GO:0040020 12 7 0,000 0,02049795 0,05723028 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02049795 0,05716495 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02049795 0,05709977 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02049795 0,05703473 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02049795 0,05696985 ! transcription termination GO:0006353 14 7 0,000 0,02049795 0,05690511 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02049795 0,05684052 ! anaphase GO:0051322 18 7 0,000 0,02049795 0,05677607 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02049795 0,05671177 ! axonal fasciculation GO:0007413 19 7 0,000 0,02049795 0,05664762 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02049795 0,05658361 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02049795 0,05651975 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02049795 0,05645603 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02049795 0,05639245 ! diuresis GO:0030146 12 7 0,000 0,02049795 0,05632901 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02049795 0,05626572 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02049795 0,05620257 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02049795 0,05613957 ! antibiotic transport GO:0042891 9 7 0,000 0,02049795 0,0560767 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02049795 0,05601398 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02049795 0,05595139 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02049795 0,05588894 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02049795 0,05582664 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02049795 0,05576447 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02049795 0,05570244 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02049795 0,05564055 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02049795 0,05557879 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02049795 0,05551718 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02049795 0,0554557 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02049795 0,05539435 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02049795 0,05533314 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02049795 0,05527207 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02049795 0,05521113 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02049795 0,05515032 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02049795 0,05508965 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02049795 0,05502911 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02049795 0,05496871 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02049795 0,05490844 ! muscle adaptation GO:0043500 13 7 0,000 0,02049795 0,0548483 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02049795 0,05478829 ! retina homeostasis GO:0001895 12 7 0,000 0,02049795 0,05472841 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02049795 0,05466866 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02049795 0,05460904 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02049795 0,05454956 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02049795 0,0544902 ! reproductive structure development GO:0048608 131 75 1,000 0,02085208 0,05537133 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,02085208 0,05531121 ! axon guidance GO:0007411 162 75 1,000 0,02085208 0,05525122 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,02137495 0,05657531 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,02190326 0,05791089 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,02243696 0,05925784 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,02297603 0,06061603 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02339205 0,06164702 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02339205 0,06158059 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02339205 0,0615143 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02339205 0,06144816 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02339205 0,06138215 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02339205 0,06131629 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02339205 0,06125057 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02339205 0,061185 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02339205 0,06111956 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02339205 0,06105426 ! meiotic prophase I GO:0007128 14 8 0,000 0,02339205 0,0609891 ! response to zinc ion GO:0010043 12 8 0,000 0,02339205 0,06092408 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02339205 0,0608592 ! oligopeptide transport GO:0006857 16 8 0,000 0,02339205 0,06079445 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02339205 0,06072985 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02339205 0,06066538 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02339205 0,06060105 ! signal peptide processing GO:0006465 12 8 0,000 0,02339205 0,06053685 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02339205 0,06047279 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02339205 0,06040887 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02339205 0,06034508 ! succinate metabolic process GO:0006105 17 8 0,000 0,02339205 0,06028142 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02339205 0,0602179 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02339205 0,06015451 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02339205 0,06009126 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02339205 0,06002814 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02339205 0,05996515 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02339205 0,05990229 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02339205 0,05983957 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02339205 0,05977697 ! reflex GO:0060004 17 8 0,000 0,02339205 0,05971451 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02339205 0,05965218 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02339205 0,05958998 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02339205 0,0595279 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02339205 0,05946596 ! pigment granule organization GO:0048753 17 8 0,000 0,02339205 0,05940414 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02339205 0,05934246 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02339205 0,0592809 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02339205 0,05921947 ! histidine catabolic process GO:0006548 10 8 0,000 0,02339205 0,05915816 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02339205 0,05909699 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02339205 0,05903594 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02339205 0,05897501 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02339205 0,05891421 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02339205 0,05885354 ! melanin metabolic process GO:0006582 17 8 0,000 0,02339205 0,05879299 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02339205 0,05873257 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02339205 0,05867227 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02339205 0,05861209 ! macrophage activation GO:0042116 13 8 0,000 0,02339205 0,05855204 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02339205 0,0584921 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02339205 0,0584323 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02339205 0,05837261 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02339205 0,05831305 ! purine salvage GO:0043101 12 8 0,000 0,02339205 0,0582536 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02339205 0,05819428 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02339205 0,05813508 ! osteoblast development GO:0002076 17 8 0,000 0,02339205 0,058076 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02339205 0,05801704 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02339205 0,0579582 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02339205 0,05789948 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02339205 0,05784088 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02339205 0,05778239 ! response to UV-B GO:0010224 17 8 0,000 0,02339205 0,05772403 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02339205 0,05766578 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02339205 0,05760765 ! intermediate filament organization GO:0045109 12 8 0,000 0,02339205 0,05754963 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02339205 0,05749174 ! cellular extravasation GO:0045123 13 8 0,000 0,02339205 0,05743396 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02339205 0,05737629 ! response to antibiotic GO:0046677 11 8 0,000 0,02339205 0,05731874 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02339205 0,05726131 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02339205 0,05720399 ! DNA topological change GO:0006265 12 8 0,000 0,02339205 0,05714679 ! response to tropane GO:0014073 15 8 0,000 0,02339205 0,0570897 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,02339205 0,05703272 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02339205 0,05697586 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02339205 0,05691911 ! mast cell activation GO:0045576 14 8 0,000 0,02339205 0,05686247 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02339205 0,05680595 ! gas homeostasis GO:0033483 14 8 0,000 0,02339205 0,05674954 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02339205 0,05669324 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02339205 0,05663705 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02339205 0,05658098 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02339205 0,05652501 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02339205 0,05646916 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02339205 0,05641341 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02339205 0,05635778 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02339205 0,05630225 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02339205 0,05624684 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02339205 0,05619153 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02339205 0,05613633 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02339205 0,05608124 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02339205 0,05602626 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02339205 0,05597139 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02339205 0,05591662 ! hormone catabolic process GO:0042447 17 8 0,000 0,02339205 0,05586196 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02339205 0,05580741 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02339205 0,05575296 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02339205 0,05569862 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02339205 0,05564439 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02339205 0,05559026 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02339205 0,05553624 ! adult feeding behavior GO:0008343 10 8 0,000 0,02339205 0,05548232 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02339205 0,0554285 ! ATP catabolic process GO:0006200 11 8 0,000 0,02339205 0,05537479 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02339205 0,05532119 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02339205 0,05526769 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02339205 0,05521429 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02339205 0,05516099 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02339205 0,0551078 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02339205 0,05505471 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02339205 0,05500172 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02339205 0,05494883 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02339205 0,05489605 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02339205 0,05484336 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02339205 0,05479078 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02339205 0,0547383 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02339205 0,05468592 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02339205 0,05463364 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02339205 0,05458146 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02339205 0,05452938 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02339205 0,05447739 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02339205 0,05442551 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02339205 0,05437373 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,02352042 0,05462014 ! response to hypoxia GO:0001666 178 81 1,000 0,0240701 0,05584355 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,0240701 0,05579057 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,02462504 0,05702272 ! protein import into nucleus GO:0006606 174 82 1,000 0,02462504 0,05696872 ! response to drug GO:0042493 149 83 1,000 0,02518519 0,05820948 ! response to oxygen levels GO:0070482 183 83 1,000 0,02518519 0,05815447 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,02518519 0,05809955 GO:0045937|positive regulation of phosphate metabolic process, ! nuclear import GO:0051170 177 83 1,000 0,02518519 0,05804474 ! T cell activation GO:0042110 189 84 1,000 0,02575053 0,05929175 ! axon extension GO:0048675 16 9 0,000 0,02627769 0,06044857 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02627769 0,06039171 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02627769 0,06033495 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02627769 0,0602783 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02627769 0,06022175 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,02627769 0,06016531 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02627769 0,06010898 ! reproductive behavior GO:0019098 22 9 0,000 0,02627769 0,06005275 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02627769 0,05999662 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02627769 0,0599406 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02627769 0,05988469 ! UTP metabolic process GO:0046051 10 9 0,000 0,02627769 0,05982888 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02627769 0,05977317 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02627769 0,05971757 ! artery development GO:0060840 25 9 0,000 0,02627769 0,05966207 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02627769 0,05960667 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02627769 0,05955138 ! equilibrioception GO:0050957 20 9 0,000 0,02627769 0,05949619 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,02627769 0,0594411 ! chemosensory behavior GO:0007635 21 9 0,000 0,02627769 0,05938611 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02627769 0,05933123 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02627769 0,05927644 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02627769 0,05922176 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02627769 0,05916718 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02627769 0,05911269 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02627769 0,05905831 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02627769 0,05900403 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02627769 0,05894985 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02627769 0,05889577 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02627769 0,05884178 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02627769 0,0587879 ! protein targeting to ER GO:0045047 25 9 0,000 0,02627769 0,05873411 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02627769 0,05868043 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02627769 0,05862684 ! T cell selection GO:0045058 27 9 0,000 0,02627769 0,05857335 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02627769 0,05851995 ! glycine catabolic process GO:0006546 15 9 0,000 0,02627769 0,05846665 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02627769 0,05841345 ! endosome organization GO:0007032 20 9 0,000 0,02627769 0,05836035 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02627769 0,05830734 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02627769 0,05825443 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02627769 0,05820162 ! mannose metabolic process GO:0006013 13 9 0,000 0,02627769 0,0581489 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02627769 0,05809628 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02627769 0,05804375 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02627769 0,05799132 ! receptor clustering GO:0043113 20 9 0,000 0,02627769 0,05793898 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02627769 0,05788673 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02627769 0,05783458 ! retinol metabolic process GO:0042572 20 9 0,000 0,02627769 0,05778253 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02627769 0,05773056 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02627769 0,05767869 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02627769 0,05762692 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02627769 0,05757523 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02627769 0,05752364 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02627769 0,05747215 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02627769 0,05742074 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02627769 0,05736942 ! response to amine stimulus GO:0014075 13 9 0,000 0,02627769 0,0573182 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02627769 0,05726707 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02627769 0,05721603 ! erythrocyte development GO:0048821 17 9 0,000 0,02627769 0,05716508 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02627769 0,05711422 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02627769 0,05706345 ! renal water homeostasis GO:0003091 15 9 0,000 0,02627769 0,05701278 ! postreplication repair GO:0006301 25 9 0,000 0,02627769 0,05696219 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02627769 0,05691169 ! icosanoid secretion GO:0032309 15 9 0,000 0,02627769 0,05686128 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02627769 0,05681096 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02627769 0,05676073 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02627769 0,05671059 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02627769 0,05666054 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02627769 0,05661057 ! sterol catabolic process GO:0016127 14 9 0,000 0,02627769 0,05656069 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02627769 0,0565109 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02627769 0,0564612 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02627769 0,05641159 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02627769 0,05636206 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02627769 0,05631262 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02627769 0,05626327 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02627769 0,056214 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02627769 0,05616482 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02627769 0,05611572 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02627769 0,05606671 ! purine base metabolic process GO:0006144 25 9 0,000 0,02627769 0,05601779 ! pigment granule transport GO:0051904 17 9 0,000 0,02627769 0,05596895 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02627769 0,0559202 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02627769 0,05587153 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02627769 0,05582294 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02627769 0,05577445 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02627769 0,05572603 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02627769 0,0556777 ! mitochondrion localization GO:0051646 18 9 0,000 0,02627769 0,05562945 ! negative regulation of transport GO:0051051 164 85 1,000 0,02632102 0,05567295 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,02632102 0,05562479 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,02689662 0,05679209 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 1,000 0,02747731 0,0579681 ! nucleosome assembly GO:0006334 126 87 1,000 0,02747731 0,05791809 ! regulation of protein transport GO:0051223 165 87 1,000 0,02747731 0,05786816 GO:0070201|regulation of establishment of protein localization, ! chromatin assembly GO:0031497 128 88 1,000 0,02806304 0,05905082 ! tube morphogenesis GO:0035239 194 89 1,000 0,02865378 0,06024198 ! protein localization in nucleus GO:0034504 192 89 1,000 0,02865378 0,06019018 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02915487 0,06119017 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02915487 0,06113764 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02915487 0,06108521 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02915487 0,06103287 ! associative learning GO:0008306 21 10 0,000 0,02915487 0,06098061 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02915487 0,06092845 ! phosphate transport GO:0006817 24 10 0,000 0,02915487 0,06087637 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02915487 0,06082438 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02915487 0,06077249 ! CTP metabolic process GO:0046036 11 10 0,000 0,02915487 0,06072068 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02915487 0,06066896 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02915487 0,06061732 ! GTP metabolic process GO:0046039 11 10 0,000 0,02915487 0,06056578 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02915487 0,06051432 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02915487 0,06046295 ! social behavior GO:0035176 29 10 0,000 0,02915487 0,06041167 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02915487 0,06036047 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02915487 0,06030936 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02915487 0,06025834 ! androgen metabolic process GO:0008209 17 10 0,000 0,02915487 0,0602074 ! phospholipid efflux GO:0033700 19 10 0,000 0,02915487 0,06015655 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02915487 0,06010578 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02915487 0,0600551 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02915487 0,06000451 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02915487 0,059954 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02915487 0,05990358 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02915487 0,05985324 ! endoderm development GO:0007492 18 10 0,000 0,02915487 0,05980298 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02915487 0,05975281 ! arginine catabolic process GO:0006527 17 10 0,000 0,02915487 0,05970273 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02915487 0,05965273 ! proline metabolic process GO:0006560 13 10 0,000 0,02915487 0,05960281 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02915487 0,05955297 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02915487 0,05950322 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02915487 0,05945355 ! V(D)J recombination GO:0033151 34 10 0,000 0,02915487 0,05940397 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02915487 0,05935446 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02915487 0,05930504 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02915487 0,0592557 ! B cell proliferation GO:0042100 19 10 0,000 0,02915487 0,05920645 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02915487 0,05915727 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02915487 0,05910818 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02915487 0,05905917 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02915487 0,05901024 ! ruffle organization GO:0031529 17 10 0,000 0,02915487 0,05896139 ! epithelial cell development GO:0002064 21 10 0,000 0,02915487 0,05891262 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02915487 0,05886393 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02915487 0,05881532 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02915487 0,05876679 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02915487 0,05871835 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02915487 0,05866998 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02915487 0,05862169 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,02915487 0,05857348 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02915487 0,05852535 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02915487 0,0584773 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02915487 0,05842933 ! segment specification GO:0007379 15 10 0,000 0,02915487 0,05838144 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02915487 0,05833362 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02915487 0,05828589 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02915487 0,05823823 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02915487 0,05819065 ! response to dsRNA GO:0043331 23 10 0,000 0,02915487 0,05814315 ! DNA ligation GO:0006266 18 10 0,000 0,02915487 0,05809572 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02915487 0,05804837 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02915487 0,0580011 ! melanosome localization GO:0032400 16 10 0,000 0,02915487 0,05795391 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02915487 0,05790679 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02915487 0,05785975 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02915487 0,05781279 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02915487 0,0577659 ! induction of an organ GO:0001759 17 10 0,000 0,02915487 0,05771909 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02915487 0,05767235 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02915487 0,05762569 ! protein sumoylation GO:0016925 17 10 0,000 0,02915487 0,05757911 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02915487 0,0575326 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02915487 0,05748616 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02915487 0,0574398 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02915487 0,05739352 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02915487 0,05734731 ! salivary gland development GO:0007431 28 10 0,000 0,02915487 0,05730117 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02915487 0,05725511 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02915487 0,05720912 ! midbrain development GO:0030901 14 10 0,000 0,02915487 0,05716321 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02915487 0,05711737 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02915487 0,0570716 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02915487 0,0570259 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02915487 0,05698028 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02915487 0,05693474 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02915487 0,05688926 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02915487 0,05684386 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02915487 0,05679853 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02915487 0,05675327 ! detection of calcium ion GO:0005513 24 10 0,000 0,02915487 0,05670808 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02915487 0,05666297 ! blastocyst formation GO:0001825 18 10 0,000 0,02915487 0,05661793 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02915487 0,05657296 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02915487 0,05652806 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02915487 0,05648323 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02915487 0,05643847 ! response to nicotine GO:0035094 20 10 0,000 0,02915487 0,05639379 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02915487 0,05634917 ! ossification GO:0001503 205 91 1,000 0,02985016 0,05764738 ! bone development GO:0060348 206 92 1,000 0,03045573 0,05877041 ! protein-DNA complex assembly GO:0065004 134 92 1,000 0,03045573 0,05872402 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,03106617 0,05985383 ! female pregnancy GO:0007565 166 94 1,000 0,03168146 0,06099118 ! regulation of membrane potential GO:0042391 179 94 1,000 0,03168146 0,06094316 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03202364 0,06155291 ! respiratory burst GO:0045730 17 11 0,000 0,03202364 0,06150452 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03202364 0,06145621 ! neuron fate specification GO:0048665 18 11 0,000 0,03202364 0,06140797 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03202364 0,0613598 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03202364 0,06131172 ! thyroid gland development GO:0030878 26 11 0,000 0,03202364 0,0612637 ! synapsis GO:0007129 14 11 0,000 0,03202364 0,06121577 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03202364 0,0611679 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03202364 0,06112012 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,03202364 0,0610724 ! response to pain GO:0048265 27 11 0,000 0,03202364 0,06102477 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,03202364 0,0609772 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03202364 0,06092971 ! bone resorption GO:0045453 16 11 0,000 0,03202364 0,0608823 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03202364 0,06083495 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,03202364 0,06078768 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03202364 0,06074049 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03202364 0,06069337 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03202364 0,06064632 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03202364 0,06059934 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03202364 0,06055244 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03202364 0,06050561 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03202364 0,06045885 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03202364 0,06041216 ! UV protection GO:0009650 20 11 0,000 0,03202364 0,06036555 ! adult heart development GO:0007512 16 11 0,000 0,03202364 0,06031901 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03202364 0,06027253 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03202364 0,06022614 ! macroautophagy GO:0016236 19 11 0,000 0,03202364 0,06017981 ! temperature homeostasis GO:0001659 18 11 0,000 0,03202364 0,06013355 ! behavioral fear response GO:0001662 27 11 0,000 0,03202364 0,06008737 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03202364 0,06004125 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03202364 0,05999521 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03202364 0,05994923 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03202364 0,05990333 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03202364 0,0598575 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03202364 0,05981174 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03202364 0,05976604 ! regulation of organ growth GO:0046620 14 11 0,000 0,03202364 0,05972042 ! pigment granule localization GO:0051875 20 11 0,000 0,03202364 0,05967487 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03202364 0,05962938 ! vasoconstriction GO:0042310 20 11 0,000 0,03202364 0,05958397 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03202364 0,05953862 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03202364 0,05949335 ! embryonic axis specification GO:0000578 19 11 0,000 0,03202364 0,05944814 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03202364 0,059403 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03202364 0,05935793 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03202364 0,05931293 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03202364 0,05926799 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03202364 0,05922313 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03202364 0,05917833 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03202364 0,0591336 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03202364 0,05908894 ! prophase GO:0051324 17 11 0,000 0,03202364 0,05904434 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03202364 0,05899981 ! nucleosome positioning GO:0016584 15 11 0,000 0,03202364 0,05895535 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03202364 0,05891096 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03202364 0,05886663 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03202364 0,05882237 ! apical protein localization GO:0045176 18 11 0,000 0,03202364 0,05877817 ! acid secretion GO:0046717 20 11 0,000 0,03202364 0,05873405 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03202364 0,05868999 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03202364 0,05864599 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03202364 0,05860206 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03202364 0,0585582 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03202364 0,0585144 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03202364 0,05847067 ! cholesterol efflux GO:0033344 21 11 0,000 0,03202364 0,058427 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03202364 0,0583834 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03202364 0,05833986 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03202364 0,05829639 ! embryonic gut development GO:0048566 19 11 0,000 0,03202364 0,05825298 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03202364 0,05820964 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03202364 0,05816636 ! activation of innate immune response GO:0002218 16 11 0,000 0,03202364 0,05812314 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03202364 0,05807999 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03202364 0,05803691 ! lysogeny GO:0030069 22 11 0,000 0,03202364 0,05799388 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03202364 0,05795093 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03202364 0,05790803 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03202364 0,0578652 ! nucleosome organization GO:0034728 143 95 1,000 0,03230156 0,05832425 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,03230156 0,05828117 ! sex differentiation GO:0007548 171 96 1,000 0,03292643 0,05936478 ! regulation of T cell activation GO:0050863 175 96 1,000 0,03292643 0,059321 ! regulation of protein localization GO:0032880 188 97 1,000 0,03355605 0,06041078 ! forebrain development GO:0030900 210 98 1,000 0,03419038 0,06150743 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,03488401 0,06270908 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,03488401 0,06266297 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,03488401 0,06261692 ! mating GO:0007618 17 12 0,000 0,03488401 0,06257095 ! protein complex disassembly GO:0043241 28 12 0,000 0,03488401 0,06252504 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,03488401 0,0624792 ! hippocampus development GO:0021766 29 12 0,000 0,03488401 0,06243343 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,03488401 0,06238773 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,03488401 0,06234209 ! T cell proliferation GO:0042098 32 12 0,000 0,03488401 0,06229652 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03488401 0,06225101 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,03488401 0,06220557 ! ventral spinal cord development GO:0021517 25 12 0,000 0,03488401 0,0621602 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,03488401 0,06211489 ! drug transport GO:0015893 16 12 0,000 0,03488401 0,06206965 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,03488401 0,06202448 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,03488401 0,06197937 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,03488401 0,06193433 ! polyamine metabolic process GO:0006595 18 12 0,000 0,03488401 0,06188935 ! focal adhesion formation GO:0048041 37 12 0,000 0,03488401 0,06184444 ! mitotic spindle organization GO:0007052 23 12 0,000 0,03488401 0,06179959 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,03488401 0,06175481 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,03488401 0,06171009 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,03488401 0,06166544 ! lipid digestion GO:0044241 21 12 0,000 0,03488401 0,06162085 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,03488401 0,06157632 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03488401 0,06153187 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,03488401 0,06148747 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,03488401 0,06144314 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03488401 0,06139887 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,03488401 0,06135467 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,03488401 0,06131053 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,03488401 0,06126645 ! snRNA metabolic process GO:0016073 30 12 0,000 0,03488401 0,06122244 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,03488401 0,06117849 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,03488401 0,0611346 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03488401 0,06109078 ! cranial nerve development GO:0021545 23 12 0,000 0,03488401 0,06104702 ! fucose catabolic process GO:0019317 25 12 0,000 0,03488401 0,06100332 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,03488401 0,06095968 ! histone acetylation GO:0016573 27 12 0,000 0,03488401 0,06091611 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,03488401 0,0608726 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03488401 0,06082915 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,03488401 0,06078576 ! zymogen activation GO:0031638 18 12 0,000 0,03488401 0,06074243 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,03488401 0,06069917 ! T cell homeostasis GO:0043029 28 12 0,000 0,03488401 0,06065597 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,03488401 0,06061283 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,03488401 0,06056975 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,03488401 0,06052673 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,03488401 0,06048377 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,03488401 0,06044087 ! defense response to fungus GO:0050832 15 12 0,000 0,03488401 0,06039804 ! developmental induction GO:0031128 22 12 0,000 0,03488401 0,06035526 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,03488401 0,06031255 ! lamellipodium assembly GO:0030032 24 12 0,000 0,03488401 0,0602699 ! response to cold GO:0009409 17 12 0,000 0,03488401 0,0602273 ! establishment of cell polarity GO:0030010 21 12 0,000 0,03488401 0,06018477 ! regulation of synapse organization GO:0050807 18 12 0,000 0,03488401 0,0601423 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,03547303 0,06111468 GO:0060538|skeletal muscle organ development, ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,03773601 0,06496763 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03773601 0,06492188 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,03773601 0,06487619 ! regulation of chemokine production GO:0032642 18 13 0,000 0,03773601 0,06483057 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,03773601 0,06478501 ! peroxisomal transport GO:0043574 28 13 0,000 0,03773601 0,06473951 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,03773601 0,06469408 ! cartilage condensation GO:0001502 22 13 0,000 0,03773601 0,06464871 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,03773601 0,06460341 ! organelle fusion GO:0048284 36 13 0,000 0,03773601 0,06455817 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,03773601 0,06451299 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,03773601 0,06446788 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,03773601 0,06442283 ! endocrine pancreas development GO:0031018 25 13 0,000 0,03773601 0,06437784 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,03773601 0,06433291 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,03773601 0,06428805 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,03773601 0,06424325 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,03773601 0,06419851 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,03773601 0,06415384 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03773601 0,06410922 ! methionine metabolic process GO:0006555 31 13 0,000 0,03773601 0,06406467 ! plasma membrane organization GO:0007009 27 13 0,000 0,03773601 0,06402018 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,03773601 0,06397576 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,03773601 0,06393139 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,03773601 0,06388709 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,03773601 0,06384284 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,03773601 0,06379866 ! exocrine system development GO:0035272 34 13 0,000 0,03773601 0,06375454 ! asymmetric protein localization GO:0008105 24 13 0,000 0,03773601 0,06371048 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,03773601 0,06366648 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,03773601 0,06362254 ! L-glutamate transport GO:0015813 30 13 0,000 0,03773601 0,06357866 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,03773601 0,06353485 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,03773601 0,06349109 ! protein homotetramerization GO:0051289 24 13 0,000 0,03773601 0,06344739 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,03773601 0,06340376 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,03773601 0,06336018 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,03773601 0,06331666 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,03773601 0,06327321 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,03773601 0,06322981 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03773601 0,06318647 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,03773601 0,06314319 ! histone methylation GO:0016571 29 13 0,000 0,03773601 0,06309998 ! chromatin silencing GO:0006342 29 13 0,000 0,03773601 0,06305682 ! gland morphogenesis GO:0022612 31 13 0,000 0,03773601 0,06301371 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,03773601 0,06297067 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,03773601 0,06292769 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03773601 0,06288476 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,03773601 0,0628419 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,03773601 0,06279909 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,03773601 0,06275634 ! spleen development GO:0048536 24 13 0,000 0,03773601 0,06271365 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,03773601 0,06267102 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,03773601 0,06262844 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,03773601 0,06258592 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,03773601 0,06254346 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03773601 0,06250106 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,03773601 0,06245872 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,03773601 0,06241643 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,03773601 0,0623742 ! insulin secretion GO:0030073 24 13 0,000 0,03773601 0,06233202 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,03773601 0,06228991 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,03773601 0,06224785 ! acrosome reaction GO:0007340 19 13 0,000 0,03773601 0,06220585 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,03773601 0,0621639 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,03773601 0,06212201 ! rRNA transcription GO:0009303 28 14 0,000 0,04057966 0,06675832 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04057966 0,06671339 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,04057966 0,06666853 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04057966 0,06662372 ! non-recombinational repair GO:0000726 29 14 0,000 0,04057966 0,06657898 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04057966 0,0665343 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04057966 0,06648967 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04057966 0,06644511 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04057966 0,0664006 ! lipid localization GO:0010876 32 14 0,000 0,04057966 0,06635616 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04057966 0,06631177 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,04057966 0,06626745 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04057966 0,06622318 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04057966 0,06617897 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04057966 0,06613482 ! arginine metabolic process GO:0006525 21 14 0,000 0,04057966 0,06609073 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04057966 0,0660467 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,04057966 0,06600273 ! regulation of heart rate GO:0002027 25 14 0,000 0,04057966 0,06595882 ! fear response GO:0042596 34 14 0,000 0,04057966 0,06591496 ! organic alcohol transport GO:0015850 29 14 0,000 0,04057966 0,06587116 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04057966 0,06582742 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,04057966 0,06578374 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,04057966 0,06574012 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04057966 0,06569655 ! bone mineralization GO:0030282 18 14 0,000 0,04057966 0,06565305 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04057966 0,0656096 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,04057966 0,0655662 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04057966 0,06552287 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04057966 0,06547959 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04057966 0,06543637 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,04057966 0,06539321 ! ribosome assembly GO:0042255 18 14 0,000 0,04057966 0,0653501 ! cerebellum development GO:0021549 23 14 0,000 0,04057966 0,06530705 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04057966 0,06526406 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,04057966 0,06522112 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04057966 0,06517824 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04057966 0,06513541 ! NADP metabolic process GO:0006739 24 14 0,000 0,04057966 0,06509265 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,04057966 0,06504993 ! oxygen transport GO:0015671 22 14 0,000 0,04057966 0,06500728 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04057966 0,06496468 ! male genitalia development GO:0030539 26 14 0,000 0,04057966 0,06492213 ! regulation of axon extension GO:0030516 43 14 0,000 0,04057966 0,06487965 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04057966 0,06483721 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04057966 0,06479484 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,04341498 0,06927681 ! lactation GO:0007595 30 15 0,000 0,04341498 0,06923159 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,04341498 0,06918643 ! reproductive cellular process GO:0048610 22 15 0,000 0,04341498 0,06914133 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,04341498 0,06909629 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,04341498 0,0690513 ! superoxide anion generation GO:0042554 22 15 0,000 0,04341498 0,06900638 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,04341498 0,06896151 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,04341498 0,0689167 ! copper ion transport GO:0006825 22 15 0,000 0,04341498 0,06887195 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,04341498 0,06882726 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,04341498 0,06878262 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,04341498 0,06873804 ! sulfate transport GO:0008272 27 15 0,000 0,04341498 0,06869352 ! response to cAMP GO:0051591 25 15 0,000 0,04341498 0,06864906 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,04341498 0,06860466 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,04341498 0,06856031 ! response to hexose stimulus GO:0009746 25 15 0,000 0,04341498 0,06851602 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,04341498 0,06847179 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,04341498 0,06842761 ! vesicle coating GO:0006901 38 15 0,000 0,04341498 0,0683835 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,04341498 0,06833943 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,04341498 0,06829543 ! regulation of exocytosis GO:0017157 26 15 0,000 0,04341498 0,06825148 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,04341498 0,06820759 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,04341498 0,06816375 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,04341498 0,06811998 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,04341498 0,06807625 ! regulation of vasodilation GO:0042312 27 15 0,000 0,04341498 0,06803259 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,04341498 0,06798898 ! histone deacetylation GO:0016575 24 15 0,000 0,04341498 0,06794542 ! water homeostasis GO:0030104 28 15 0,000 0,04341498 0,06790192 ! cofactor transport GO:0051181 30 15 0,000 0,04341498 0,06785848 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,04341498 0,06781509 ! muscle maintenance GO:0046716 26 15 0,000 0,04341498 0,06777176 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,04341498 0,06772848 ! intestinal absorption GO:0050892 31 15 0,000 0,04341498 0,06768526 ! dopamine metabolic process GO:0042417 35 15 0,000 0,04341498 0,06764209 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,04341498 0,06759898 ! heme biosynthetic process GO:0006783 33 15 0,000 0,04341498 0,06755592 ! cell killing GO:0001906 32 15 0,000 0,04341498 0,06751292 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,04341498 0,06746998 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,04341498 0,06742708 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,04341498 0,06738425 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,04341498 0,06734146 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,04341498 0,06729873 ! actin filament polymerization GO:0030041 27 15 0,000 0,04341498 0,06725606 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,04341498 0,06721344 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,04624201 0,07154479 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04624201 0,07149951 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04624201 0,07145429 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04624201 0,07140912 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,04624201 0,07136401 ! bone remodeling GO:0046849 28 16 0,000 0,04624201 0,07131896 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04624201 0,07127396 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04624201 0,07122902 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04624201 0,07118414 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04624201 0,07113931 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04624201 0,07109454 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,04624201 0,07104983 ! startle response GO:0001964 28 16 0,000 0,04624201 0,07100517 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04624201 0,07096057 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04624201 0,07091602 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04624201 0,07087154 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04624201 0,0708271 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04624201 0,07078272 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04624201 0,0707384 ! pituitary gland development GO:0021983 30 16 0,000 0,04624201 0,07069413 ! response to osmotic stress GO:0006970 27 16 0,000 0,04624201 0,07064992 ! lysosomal transport GO:0007041 31 16 0,000 0,04624201 0,07060577 ! fructose metabolic process GO:0006000 25 16 0,000 0,04624201 0,07056167 ! L-amino acid transport GO:0015807 33 16 0,000 0,04624201 0,07051762 ! stem cell development GO:0048864 46 16 0,000 0,04624201 0,07047363 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04624201 0,07042969 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04624201 0,07038581 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04624201 0,07034198 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04624201 0,07029821 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04624201 0,07025449 ! axon cargo transport GO:0008088 46 16 0,000 0,04624201 0,07021083 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04624201 0,07016722 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,04624201 0,07012367 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,04624201 0,07008017 ! DNA replication initiation GO:0006270 28 16 0,000 0,04624201 0,07003672 ! neuron recognition GO:0008038 40 16 0,000 0,04624201 0,06999333 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04624201 0,06994999 ! tissue regeneration GO:0042246 27 16 0,000 0,04624201 0,0699067 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04624201 0,06986347 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04624201 0,06982029 ! biomineral formation GO:0031214 22 16 0,000 0,04624201 0,06977716 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04624201 0,06973409 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04624201 0,06969107 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,04624201 0,06964811 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04624201 0,06960519 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04624201 0,06956233 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04624201 0,06951952 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04624201 0,06947677 ! peptide hormone processing GO:0016486 27 16 0,000 0,04624201 0,06943407 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,04906076 0,07362128 ! metencephalon development GO:0022037 32 17 0,000 0,04906076 0,07357608 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,04906076 0,07353094 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,04906076 0,07348586 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,04906076 0,07344083 ! signal complex assembly GO:0007172 47 17 0,000 0,04906076 0,07339586 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,04906076 0,07335094 ! glial cell development GO:0021782 28 17 0,000 0,04906076 0,07330608 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,04906076 0,07326127 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,04906076 0,07321652 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,04906076 0,07317182 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,04906076 0,07312717 ! myoblast differentiation GO:0045445 50 17 0,000 0,04906076 0,07308258 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,04906076 0,07303805 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,04906076 0,07299357 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,04906076 0,07294914 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,04906076 0,07290477 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,04906076 0,07286045 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,04906076 0,07281618 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,04906076 0,07277197 ! membrane budding GO:0006900 42 17 0,000 0,04906076 0,07272781 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,04906076 0,07268371 ! regulation of protein binding GO:0043393 33 17 0,000 0,04906076 0,07263966 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,04906076 0,07259566 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,04906076 0,07255172 ! genitalia development GO:0048806 32 17 0,000 0,04906076 0,07250783 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,04906076 0,07246399 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,04906076 0,0724202 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,04906076 0,07237647 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,04906076 0,07233279 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,04906076 0,07228917 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,04906076 0,07224559 ! steroid catabolic process GO:0006706 34 17 0,000 0,04906076 0,07220207 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,04906076 0,0721586 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,04906076 0,07211518 ! gas transport GO:0015669 26 17 0,000 0,04906076 0,07207182 ! organic cation transport GO:0015695 32 17 0,000 0,04906076 0,07202851 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,04906076 0,07198525 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,04906076 0,07194204 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,05187126 0,07601769 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,05187126 0,07597211 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,05187126 0,0759266 ! limbic system development GO:0021761 40 18 0,000 0,05187126 0,07588113 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,05187126 0,07583572 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,05187126 0,07579036 ! adult walking behavior GO:0007628 36 18 0,000 0,05187126 0,07574506 ! patterning of blood vessels GO:0001569 43 18 0,000 0,05187126 0,07569981 ! heart looping GO:0001947 34 18 0,000 0,05187126 0,07565462 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,05187126 0,07560948 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,05187126 0,07556439 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,05187126 0,07551936 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,05187126 0,07547438 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,05187126 0,07542946 ! glycine metabolic process GO:0006544 30 18 0,000 0,05187126 0,07538458 ! glutamine metabolic process GO:0006541 29 18 0,000 0,05187126 0,07533977 ! response to retinoic acid GO:0032526 31 18 0,000 0,05187126 0,075295 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,05187126 0,07525029 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,05187126 0,07520563 ! DNA integration GO:0015074 32 18 0,000 0,05187126 0,07516102 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,05187126 0,07511647 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,05187126 0,07507197 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,05187126 0,07502752 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,05187126 0,07498313 ! neural crest cell migration GO:0001755 41 18 0,000 0,05187126 0,07493879 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,05187126 0,0748945 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,05187126 0,07485026 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,05187126 0,07480607 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,05187126 0,07476194 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,05187126 0,07471786 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,05187126 0,07467383 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,05187126 0,07462985 ! detection of bacterium GO:0016045 22 18 0,000 0,05187126 0,07458593 ! nerve development GO:0021675 34 18 0,000 0,05187126 0,07454205 ! defense response to virus GO:0051607 43 18 0,000 0,05187126 0,07449823 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,05187126 0,07445446 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,05187126 0,07441074 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,05467353 0,07838465 ! positive regulation of translation GO:0045727 31 19 0,000 0,05467353 0,07833867 ! negative regulation of defense response GO:0031348 27 19 0,000 0,05467353 0,07829275 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,05467353 0,07824689 ! neuron maturation GO:0042551 46 19 0,000 0,05467353 0,07820108 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,05467353 0,07815532 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,05467353 0,07810961 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,05467353 0,07806396 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,05467353 0,07801836 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,05467353 0,07797282 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,05467353 0,07792733 ! memory GO:0007613 34 19 0,000 0,05467353 0,07788189 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,05467353 0,0778365 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,05467353 0,07779117 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,05467353 0,07774589 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,05467353 0,07770066 ! cerebral cortex development GO:0021987 40 19 0,000 0,05467353 0,07765549 ! pigmentation during development GO:0048066 42 19 0,000 0,05467353 0,07761036 ! response to vitamin A GO:0033189 32 19 0,000 0,05467353 0,07756529 ! heme metabolic process GO:0042168 40 19 0,000 0,05467353 0,07752028 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,05467353 0,07747531 ! response to fungus GO:0009620 26 19 0,000 0,05467353 0,0774304 ! peptide cross-linking GO:0018149 39 19 0,000 0,05467353 0,07738554 ! protein export from nucleus GO:0006611 40 19 0,000 0,05467353 0,07734073 ! heart process GO:0003015 32 19 0,000 0,05467353 0,07729597 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,05467353 0,07725127 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,05467353 0,07720661 ! visual learning GO:0008542 38 19 0,000 0,05467353 0,07716201 ! cellular pigmentation GO:0033059 37 19 0,000 0,05467353 0,07711746 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,05467353 0,07707296 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,05467353 0,07702851 ! vitamin transport GO:0051180 31 19 0,000 0,05467353 0,07698411 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,05467353 0,07693977 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,05467353 0,07689547 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,05467353 0,07685123 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,05467353 0,07680704 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,05467353 0,0767629 ! cilium assembly GO:0042384 38 19 0,000 0,05467353 0,0767188 ! peptide hormone secretion GO:0030072 32 19 0,000 0,05467353 0,07667476 ! protein secretion GO:0009306 45 20 0,000 0,0574676 0,08054696 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,0574676 0,08050077 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,0574676 0,08045464 ! positive regulation of ossification GO:0045778 50 20 0,000 0,0574676 0,08040856 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,0574676 0,08036253 ! skin development GO:0043588 42 20 0,000 0,0574676 0,08031656 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,0574676 0,08027064 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,0574676 0,08022477 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,0574676 0,08017895 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,0574676 0,08013319 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,0574676 0,08008748 ! response to vitamin GO:0033273 36 20 0,000 0,0574676 0,08004182 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,0574676 0,07999621 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,0574676 0,07995065 ! bile acid metabolic process GO:0008206 34 20 0,000 0,0574676 0,07990515 ! response to alkaloid GO:0043279 38 20 0,000 0,0574676 0,0798597 ! retinoid metabolic process GO:0001523 34 20 0,000 0,0574676 0,0798143 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,0574676 0,07976895 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,0574676 0,07972365 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,0574676 0,0796784 GO:0032392|DNA geometric change, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,0574676 0,07963321 ! actin filament bundle formation GO:0051017 47 20 0,000 0,0574676 0,07958807 ! body fluid secretion GO:0007589 33 20 0,000 0,0574676 0,07954297 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,0574676 0,07949793 ! peptide secretion GO:0002790 38 20 0,000 0,0574676 0,07945294 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,0574676 0,079408 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,0574676 0,07936311 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,0574676 0,07931828 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,0574676 0,07927349 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,0574676 0,07922875 ! cell-cell junction organization GO:0045216 43 20 0,000 0,0574676 0,07918406 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,0574676 0,07913943 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,0574676 0,07909484 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,0574676 0,07905031 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,0574676 0,07900582 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,0574676 0,07896139 ! regulation of glucose import GO:0046324 30 20 0,000 0,0574676 0,078917 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,0574676 0,07887267 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,0574676 0,07882838 ! negative regulation of translation GO:0017148 32 20 0,000 0,0574676 0,07878415 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,0574676 0,07873996 ! regulation of cell killing GO:0031341 46 21 0,000 0,06025349 0,0825108 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,06025349 0,08246458 ! hormone secretion GO:0046879 39 21 0,000 0,06025349 0,08241841 ! cAMP metabolic process GO:0046058 41 21 0,000 0,06025349 0,08237228 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,06025349 0,08232621 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,06025349 0,0822802 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,06025349 0,08223423 ! ovarian follicle development GO:0001541 39 21 0,000 0,06025349 0,08218832 ! smooth muscle contraction GO:0006939 48 21 0,000 0,06025349 0,08214245 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,06025349 0,08209664 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,06025349 0,08205088 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,06025349 0,08200517 ! plasma membrane fusion GO:0045026 33 21 0,000 0,06025349 0,08195951 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,06025349 0,0819139 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,06025349 0,08186834 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,06025349 0,08182283 ! sensory perception of pain GO:0019233 33 21 0,000 0,06025349 0,08177737 ! diencephalon development GO:0021536 36 21 0,000 0,06025349 0,08173197 ! collagen fibril organization GO:0030199 62 21 0,000 0,06025349 0,08168661 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,06025349 0,0816413 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,06025349 0,08159605 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,06025349 0,08155084 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,06025349 0,08150569 ! collagen catabolic process GO:0030574 29 21 0,000 0,06025349 0,08146058 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,06025349 0,08141553 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,06025349 0,08137052 ! sperm-egg recognition GO:0035036 23 21 0,000 0,06025349 0,08132556 ! actin filament-based movement GO:0030048 47 21 0,000 0,06025349 0,08128066 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,06303122 0,08498083 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,06303122 0,08493396 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,06303122 0,08488714 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,06303122 0,08484037 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,06303122 0,08479365 ! microtubule-based transport GO:0010970 59 22 0,000 0,06303122 0,08474699 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,06303122 0,08470037 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,06303122 0,08465381 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,06303122 0,08460729 ! vacuolar transport GO:0007034 41 22 0,000 0,06303122 0,08456083 ! central nervous system neuron development GO:0021954 47 22 0,000 0,06303122 0,08451442 ! fucose metabolic process GO:0006004 44 22 0,000 0,06303122 0,08446806 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,06303122 0,08442175 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,06303122 0,08437549 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,06303122 0,08432928 ! ureteric bud development GO:0001657 50 22 0,000 0,06303122 0,08428313 ! stem cell differentiation GO:0048863 57 22 0,000 0,06303122 0,08423702 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,06303122 0,08419096 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,06303122 0,08414496 ! cytolysis GO:0019835 27 22 0,000 0,06303122 0,084099 ! renal system process GO:0003014 42 22 0,000 0,06303122 0,0840531 ! vasodilation GO:0042311 40 22 0,000 0,06303122 0,08400724 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,06303122 0,08396144 ! G1 phase GO:0051318 44 22 0,000 0,06303122 0,08391568 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,06303122 0,08386997 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,06303122 0,08382432 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,06303122 0,08377871 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,06303122 0,08373316 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,06303122 0,08368765 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,06303122 0,08364219 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,06303122 0,08359678 ! sarcomere organization GO:0045214 32 22 0,000 0,06303122 0,08355142 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,06303122 0,08350611 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,06303122 0,08346085 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,06303122 0,08341564 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,06303122 0,08337048 ! gut development GO:0048565 44 22 0,000 0,06303122 0,08332536 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,06303122 0,0832803 ! protein stabilization GO:0050821 41 22 0,000 0,06303122 0,08323528 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,06580082 0,08684571 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,06580082 0,08679881 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,06580082 0,08675197 ! gluconeogenesis GO:0006094 38 23 0,000 0,06580082 0,08670518 ! glycerol metabolic process GO:0006071 40 23 0,000 0,06580082 0,08665844 ! viral genome replication GO:0019079 44 23 0,000 0,06580082 0,08661175 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,06580082 0,08656511 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,06580082 0,08651852 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,06580082 0,08647198 ! regeneration GO:0031099 42 23 0,000 0,06580082 0,08642549 ! axis specification GO:0009798 43 23 0,000 0,06580082 0,08637905 ! visual behavior GO:0007632 46 23 0,000 0,06580082 0,08633266 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,06580082 0,08628631 ! response to ethanol GO:0045471 47 23 0,000 0,06580082 0,08624002 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,06580082 0,08619378 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,06580082 0,08614759 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,06580082 0,08610145 ! peroxisome organization GO:0007031 43 23 0,000 0,06580082 0,08605536 ! lysosome organization GO:0007040 47 23 0,000 0,06580082 0,08600931 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,06580082 0,08596332 ! vesicle targeting GO:0006903 49 23 0,000 0,06580082 0,08591737 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,06580082 0,08587148 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,06580082 0,08582563 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,06580082 0,08577983 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,06580082 0,08573408 ! DNA modification GO:0006304 36 23 0,000 0,06580082 0,08568838 ! fatty acid transport GO:0015908 47 23 0,000 0,06580082 0,08564273 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,06580082 0,08559713 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,06580082 0,08555157 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,06580082 0,08550607 ! hormone transport GO:0009914 41 23 0,000 0,06580082 0,08546061 ! cell-cell recognition GO:0009988 28 23 0,000 0,06580082 0,0854152 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,06580082 0,08536984 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,06580082 0,08532452 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,06580082 0,08527926 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,06856231 0,0888111 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,06856231 0,08876403 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,06856231 0,08871702 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,06856231 0,08867005 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,06856231 0,08862314 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,06856231 0,08857627 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,06856231 0,08852945 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,06856231 0,08848269 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,06856231 0,08843597 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,06856231 0,0883893 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,06856231 0,08834268 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,06856231 0,08829611 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,06856231 0,08824959 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,06856231 0,08820312 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,06856231 0,0881567 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,06856231 0,08811032 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,06856231 0,088064 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,06856231 0,08801772 ! membrane depolarization GO:0051899 45 24 0,000 0,06856231 0,08797149 ! pallium development GO:0021543 56 24 0,000 0,06856231 0,08792532 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,06856231 0,08787918 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,06856231 0,0878331 ! platelet activation GO:0030168 41 24 0,000 0,06856231 0,08778707 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,06856231 0,08774108 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,06856231 0,08769514 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,06856231 0,08764926 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,06856231 0,08760341 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,06856231 0,08755762 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,06856231 0,08751187 ! regulation of amine transport GO:0051952 41 24 0,000 0,06856231 0,08746618 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,06856231 0,08742053 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,07131572 0,09088383 ! leukocyte adhesion GO:0007159 55 25 0,000 0,07131572 0,09083644 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,07131572 0,09078911 ! phototransduction GO:0007602 37 25 0,000 0,07131572 0,09074182 ! keratinization GO:0031424 37 25 0,000 0,07131572 0,09069458 ! vacuole organization GO:0007033 49 25 0,000 0,07131572 0,0906474 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,07131572 0,09060026 ! receptor metabolic process GO:0043112 53 25 0,000 0,07131572 0,09055317 ! chromosome condensation GO:0030261 48 25 0,000 0,07131572 0,09050613 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,07131572 0,09045914 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,07131572 0,09041219 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,07131572 0,0903653 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,07131572 0,09031845 ! immunoglobulin production GO:0002377 62 25 0,000 0,07131572 0,09027166 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,07131572 0,09022491 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,07131572 0,09017821 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,07131572 0,09013155 ! liver development GO:0001889 55 25 0,000 0,07131572 0,09008495 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,07406106 0,09350448 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,07406106 0,09345618 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,07406106 0,09340793 ! molting cycle process GO:0022404 52 26 0,000 0,07406106 0,09335974 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,07406106 0,09331159 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,07406106 0,09326349 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,07406106 0,09321544 ! spinal cord development GO:0021510 54 26 0,000 0,07406106 0,09316744 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,07406106 0,09311949 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,07406106 0,09307159 ! digestive system process GO:0022600 49 26 0,000 0,07406106 0,09302374 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,07406106 0,09297593 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,07406106 0,09292818 ! osteoblast differentiation GO:0001649 63 26 0,000 0,07406106 0,09288048 ! neural crest cell development GO:0014032 59 26 0,000 0,07406106 0,09283282 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,07406106 0,09278522 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,07406106 0,09273766 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,07406106 0,09269015 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,07406106 0,09264269 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,07406106 0,09259528 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,07406106 0,09254791 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,07406106 0,0925006 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,07406106 0,09245333 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,07406106 0,09240611 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,07406106 0,09235894 ! telomere organization GO:0032200 46 26 0,000 0,07406106 0,09231182 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,07406106 0,09226475 ! neural tube closure GO:0001843 58 26 0,000 0,07406106 0,09221772 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,07406106 0,09217074 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,07406106 0,09212381 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,07406106 0,09207693 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,07679836 0,09543154 ! embryonic pattern specification GO:0009880 49 27 0,000 0,07679836 0,09538302 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,07679836 0,09533456 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,07679836 0,09528614 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,07679836 0,09523777 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,07679836 0,09518945 ! iron ion transport GO:0006826 65 27 0,000 0,07679836 0,09514118 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,07679836 0,09509296 ! superoxide metabolic process GO:0006801 41 27 0,000 0,07679836 0,09504478 ! tube lumen formation GO:0035148 59 27 0,000 0,07679836 0,09499666 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,07679836 0,09494859 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,07679836 0,09490056 ! response to toxin GO:0009636 49 27 0,000 0,07679836 0,09485258 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,07679836 0,09480465 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,07679836 0,09475677 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,07679836 0,09470894 ! leukocyte proliferation GO:0070661 59 27 0,000 0,07679836 0,09466115 GO:0032943|mononuclear cell proliferation, ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,07952765 0,09797582 ! protein amino acid acylation GO:0043543 59 28 0,000 0,07952765 0,09792644 ! vesicle docking GO:0048278 55 28 0,000 0,07952765 0,09787711 ! circadian rhythm GO:0007623 56 28 0,000 0,07952765 0,09782782 ! dendrite development GO:0016358 67 28 0,000 0,07952765 0,09777859 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,07952765 0,09772941 ! fat cell differentiation GO:0045444 57 28 0,000 0,07952765 0,09768027 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,07952765 0,09763119 ! sperm motility GO:0030317 37 28 0,000 0,07952765 0,09758215 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,07952765 0,09753316 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,07952765 0,09748422 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,07952765 0,09743534 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,07952765 0,0973865 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,07952765 0,0973377 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,07952765 0,09728896 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,07952765 0,09724027 ! glutathione metabolic process GO:0006749 42 28 0,000 0,07952765 0,09719163 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,07952765 0,09714303 ! lipid oxidation GO:0034440 48 28 0,000 0,07952765 0,09709448 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,07952765 0,09704598 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,07952765 0,09699753 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,08224895 0,10026656 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,08224895 0,10021655 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,08224895 0,10016659 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,08224895 0,10011669 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,08224895 0,10006683 ! primary neural tube formation GO:0014020 61 29 0,000 0,08224895 0,10001702 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,08224895 0,09996726 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,08224895 0,09991755 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,08224895 0,09986789 ! somitogenesis GO:0001756 52 29 0,000 0,08224895 0,09981828 ! synaptogenesis GO:0007416 46 29 0,000 0,08224895 0,09976871 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,08224895 0,0997192 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,08224895 0,09966974 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,08496228 0,10290672 ! phenol metabolic process GO:0018958 56 30 0,000 0,08496228 0,10285572 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,08496228 0,10280478 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,08496228 0,10275389 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,08496228 0,10270304 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,08496228 0,10265225 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,08496228 0,10260151 ! acute-phase response GO:0006953 50 30 0,000 0,08496228 0,10255082 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,08496228 0,10250017 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,08496228 0,10244958 ! myofibril assembly GO:0030239 50 30 0,000 0,08496228 0,10239904 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,08496228 0,10234855 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,08496228 0,1022981 ! cell fate determination GO:0001709 64 30 0,000 0,08496228 0,10224771 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,08496228 0,10219737 ! phospholipid transport GO:0015914 65 30 0,000 0,08496228 0,10214707 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,08496228 0,10209683 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,08496228 0,10204663 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,08496228 0,10199649 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,08496228 0,10194639 GO:0043433|negative regulation of transcription factor activity, ! regulation of coagulation GO:0050818 52 30 0,000 0,08496228 0,10189634 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,08766766 0,10508935 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,08766766 0,10503781 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,08766766 0,10498632 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,08766766 0,10493488 ! cell junction assembly GO:0034329 85 31 0,000 0,08766766 0,1048835 ! regulation of innate immune response GO:0045088 57 31 0,000 0,08766766 0,10483216 ! ovulation cycle process GO:0022602 55 31 0,000 0,08766766 0,10478087 ! peptide transport GO:0015833 60 31 0,000 0,08766766 0,10472963 ! male gonad development GO:0008584 56 31 0,000 0,08766766 0,10467845 ! iron ion homeostasis GO:0055072 60 31 0,000 0,08766766 0,10462731 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,08766766 0,10457622 ! detection of light stimulus GO:0009583 44 31 0,000 0,08766766 0,10452518 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,08766766 0,10447419 ! natural killer cell activation GO:0030101 50 31 0,000 0,08766766 0,10442326 ! cofactor catabolic process GO:0051187 54 31 0,000 0,08766766 0,10437237 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,08766766 0,10432153 ! eye morphogenesis GO:0048592 65 31 0,000 0,08766766 0,10427074 ! response to heat GO:0009408 54 31 0,000 0,08766766 0,10422 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,08766766 0,10416931 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,09036512 0,10732231 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,09036512 0,10727016 ! collagen metabolic process GO:0032963 49 32 0,000 0,09036512 0,10721806 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,09036512 0,10716602 ! spindle organization GO:0007051 50 32 0,000 0,09036512 0,10711402 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,09036512 0,10706207 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,09036512 0,10701018 ! metanephros development GO:0001656 81 32 0,000 0,09036512 0,10695833 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,09036512 0,10690653 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,09036512 0,10685479 ! muscle cell development GO:0055001 52 32 0,000 0,09036512 0,10680309 ! mesoderm formation GO:0001707 73 32 0,000 0,09036512 0,10675145 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,09036512 0,10669985 ! ovulation cycle GO:0042698 57 32 0,000 0,09036512 0,10664831 ! BMP signaling pathway GO:0030509 71 32 0,000 0,09036512 0,10659681 ! hindbrain development GO:0030902 65 32 0,000 0,09036512 0,10654536 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,09036512 0,10649397 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,09036512 0,10644262 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,09305468 0,10955787 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,09305468 0,1095051 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,09305468 0,10945238 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,09305468 0,10939971 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,09305468 0,10934709 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,09305468 0,10929451 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,09305468 0,10924199 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,09305468 0,10918952 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,09305468 0,10913711 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,09305468 0,10908474 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,09305468 0,10903242 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,09573637 0,11212078 ! glial cell differentiation GO:0010001 67 34 0,000 0,09573637 0,11206705 ! post-embryonic development GO:0009791 76 34 0,000 0,09573637 0,11201338 ! cholesterol transport GO:0030301 62 34 0,000 0,09573637 0,11195976 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,09573637 0,11190619 ! spliceosome assembly GO:0000245 75 34 0,000 0,09573637 0,11185267 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,09573637 0,11179921 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,09573637 0,11174579 ! formation of primary germ layer GO:0001704 76 34 0,000 0,09573637 0,11169243 ! cell fate specification GO:0001708 56 34 0,000 0,09573637 0,11163911 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,09573637 0,11158585 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,09573637 0,11153264 ! adult locomotory behavior GO:0008344 62 34 0,000 0,09573637 0,11147948 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,0984102 0,1145384 ! negative regulation of secretion GO:0051048 68 35 0,000 0,0984102 0,11448386 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,0984102 0,11442937 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,0984102 0,11437493 ! membrane docking GO:0022406 69 35 0,000 0,0984102 0,11432055 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,0984102 0,11426621 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,0984102 0,11421193 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,0984102 0,1141577 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,0984102 0,11410352 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,0984102 0,11404939 ! ceramide metabolic process GO:0006672 72 35 0,000 0,0984102 0,11399531 ! telencephalon development GO:0021537 81 35 0,000 0,0984102 0,11394128 ! sterol transport GO:0015918 63 35 0,000 0,0984102 0,11388731 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,0984102 0,11383338 ! placenta development GO:0001890 53 35 0,000 0,0984102 0,11377951 ! vesicle localization GO:0051648 70 35 0,000 0,0984102 0,11372569 ! regulation of muscle development GO:0048634 82 36 0,000 0,10107619 0,11675137 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,10107619 0,11669619 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,10107619 0,11664107 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,10107619 0,116586 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,10107619 0,11653098 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,10107619 0,11647601 ! positive regulation of cell development GO:0010720 85 36 0,000 0,10107619 0,11642109 ! protein targeting to membrane GO:0006612 75 36 0,000 0,10107619 0,11636623 ! regulation of proteolysis GO:0030162 77 36 0,000 0,10107619 0,11631142 ! aerobic respiration GO:0009060 56 36 0,000 0,10107619 0,11625666 ! cytokine production GO:0001816 68 36 0,000 0,10107619 0,11620195 ! embryonic organ development GO:0048568 67 36 0,000 0,10107619 0,11614729 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,10107619 0,11609269 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,10107619 0,11603813 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,10373438 0,11903386 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,10373438 0,11897798 ! sister chromatid segregation GO:0000819 65 37 0,000 0,10373438 0,11892215 ! odontogenesis GO:0042476 74 37 0,000 0,10373438 0,11886637 ! actomyosin structure organization GO:0031032 68 37 0,000 0,10373438 0,11881064 ! cell junction organization GO:0034330 96 37 0,000 0,10373438 0,11875497 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,10373438 0,11869934 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,10373438 0,11864377 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,10373438 0,11858825 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,10373438 0,11853279 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,10638479 0,12150446 ! meiosis I GO:0007127 74 38 0,000 0,10638479 0,12144768 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,10638479 0,12139096 ! organic anion transport GO:0015711 82 38 0,000 0,10638479 0,12133428 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,10638479 0,12127766 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,10638479 0,1212211 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,10638479 0,12116459 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,10638479 0,12110812 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,10638479 0,12105172 ! spermatid development GO:0007286 69 38 0,000 0,10638479 0,12099536 ! pigment metabolic process GO:0042440 87 38 0,000 0,10638479 0,12093906 ! neural tube formation GO:0001841 79 38 0,000 0,10638479 0,12088281 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,10902743 0,12382799 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,10902743 0,12377045 ! negative regulation of binding GO:0051100 71 39 0,000 0,10902743 0,12371296 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,10902743 0,12365553 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,10902743 0,12359815 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,10902743 0,12354082 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,10902743 0,12348354 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,11166233 0,12640921 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,11166233 0,12635066 ! learning GO:0007612 82 40 0,000 0,11166233 0,12629216 ! nucleus organization GO:0006997 73 40 0,000 0,11166233 0,12623372 ! lipid homeostasis GO:0055088 75 40 0,000 0,11166233 0,12617533 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,11166233 0,126117 ! RNA export from nucleus GO:0006405 61 41 0,000 0,11428951 0,12902462 ! mRNA catabolic process GO:0006402 79 41 0,000 0,11428951 0,12896502 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,11428951 0,12890548 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,11428951 0,12884599 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,11428951 0,12878656 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,11428951 0,12872719 ! gliogenesis GO:0042063 91 41 0,000 0,11428951 0,12866787 ! feeding behavior GO:0007631 69 41 0,000 0,11428951 0,1286086 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,11428951 0,12854939 ! mesenchymal cell development GO:0014031 94 41 0,000 0,11428951 0,12849023 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,11428951 0,12843113 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,11428951 0,12837208 ! spermatid differentiation GO:0048515 73 41 0,000 0,11428951 0,12831308 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,11428951 0,12825414 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,11690899 0,13113346 ! organic ether metabolic process GO:0018904 59 42 0,000 0,11690899 0,13107328 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,11690899 0,13101315 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,11690899 0,13095308 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,11690899 0,13089307 ! regulation of protein secretion GO:0050708 77 42 0,000 0,11690899 0,13083311 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,11690899 0,1307732 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,11690899 0,13071335 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,11952081 0,13357243 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 0,000 0,11952081 0,13351135 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,11952081 0,13345033 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,11952081 0,13338937 ! regulation of tube size GO:0035150 76 43 0,000 0,11952081 0,13332846 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,11952081 0,13326761 ! glucose transport GO:0015758 66 43 0,000 0,11952081 0,13320681 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,11952081 0,13314607 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,11952081 0,13308538 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,11952081 0,13302475 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,11952081 0,13296418 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,11952081 0,13290366 ! segmentation GO:0035282 78 43 0,000 0,11952081 0,13284319 ! ion transmembrane transport GO:0034220 79 43 0,000 0,11952081 0,13278278 ! neuron migration GO:0001764 85 43 0,000 0,11952081 0,13272242 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,11952081 0,13266212 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,12212497 0,13549105 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,12212497 0,13542955 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,12212497 0,1353681 ! hexose transport GO:0008645 68 44 0,000 0,12212497 0,13530671 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,12212497 0,13524537 ! striated muscle contraction GO:0006941 85 44 0,000 0,12212497 0,13518409 ! phagocytosis GO:0006909 105 44 0,000 0,12212497 0,13512287 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,12212497 0,1350617 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,1247215 0,13787087 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,1247215 0,13780851 ! biopolymer methylation GO:0043414 91 45 0,000 0,1247215 0,13774621 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,1247215 0,13768397 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,1247215 0,13762178 ! maintenance of location in cell GO:0051651 101 45 0,000 0,1247215 0,13755965 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,12731042 0,1403517 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,12731042 0,14028839 ! glycolysis GO:0006096 71 46 0,000 0,12731042 0,14022514 ! leukocyte migration GO:0050900 75 46 0,000 0,12731042 0,14016195 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,12731042 0,14009881 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,12731042 0,14003573 ! pigmentation GO:0043473 103 46 0,000 0,12731042 0,13997271 ! cell growth GO:0016049 90 46 0,000 0,12731042 0,13990975 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,12731042 0,13984684 ! neural tube development GO:0021915 91 47 0,000 0,12989176 0,14261824 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,12989176 0,14255417 ! positive regulation of defense response GO:0031349 88 48 0,000 0,13246554 0,14531357 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,13246554 0,14524835 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,13246554 0,14518318 ! cellular component disassembly GO:0022411 89 48 0,000 0,13246554 0,14511808 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,13246554 0,14505303 ! endosome transport GO:0016197 127 48 0,000 0,13246554 0,14498805 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,13246554 0,14492312 ! male sex differentiation GO:0046661 93 48 0,000 0,13246554 0,14485824 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,13246554 0,14479343 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,13246554 0,14472868 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,13246554 0,14466398 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,13246554 0,14459934 ! methylation GO:0032259 97 48 0,000 0,13246554 0,14453476 ! response to calcium ion GO:0051592 94 49 0,000 0,13503178 0,14726903 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,13503178 0,14720332 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,13503178 0,14713766 ! JNK cascade GO:0007254 106 49 0,000 0,13503178 0,14707206 ! protein homooligomerization GO:0051260 84 49 0,000 0,13503178 0,14700652 ! regulation of ion transport GO:0043269 86 50 0,000 0,13759049 0,14972542 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,13759049 0,14965876 ! endocrine system development GO:0035270 109 50 0,000 0,13759049 0,14959216 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,13759049 0,14952561 ! regulation of ossification GO:0030278 123 50 0,000 0,13759049 0,14945913 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,13759049 0,1493927 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,13759049 0,14932633 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,13759049 0,14926003 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,13759049 0,14919378 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,13759049 0,14912759 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,14014171 0,15182537 ! peptide metabolic process GO:0006518 80 51 0,000 0,14014171 0,15175807 ! response to temperature stimulus GO:0009266 84 51 0,000 0,14014171 0,15169083 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,14014171 0,15162365 ! positive regulation of binding GO:0051099 88 52 0,000 0,14268546 0,15430747 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,14268546 0,15423919 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,14268546 0,15417098 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,14268546 0,15410282 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,14268546 0,15403472 ! excretion GO:0007588 87 52 0,000 0,14268546 0,15396669 ! histone modification GO:0016570 104 52 0,000 0,14268546 0,15389871 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,14268546 0,15383079 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,14268546 0,15376294 ! amino acid activation GO:0043038 98 52 0,000 0,14268546 0,15369514 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,14522175 0,15635819 ! chromatin remodeling GO:0006338 122 53 0,000 0,14522175 0,15628931 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,14522175 0,15622049 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,14522175 0,15615173 ! vesicle organization GO:0016050 127 53 0,000 0,14522175 0,15608303 ! cartilage development GO:0051216 99 53 0,000 0,14522175 0,1560144 ! regulation of translational initiation GO:0006446 87 54 0,000 0,14775061 0,15866142 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,14775061 0,15859171 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,14775061 0,15852206 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,14775061 0,15845247 ! membrane fusion GO:0006944 122 54 0,000 0,14775061 0,15838295 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,14775061 0,15831348 ! covalent chromatin modification GO:0016569 115 54 0,000 0,14775061 0,15824408 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,14775061 0,15817473 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,14775061 0,15810545 ! RNA catabolic process GO:0006401 103 55 0,000 0,15027206 0,1607332 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,15027206 0,16066286 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,15027206 0,16059258 ! cell recognition GO:0008037 98 55 0,000 0,15027206 0,16052236 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,15027206 0,1604522 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,15027206 0,1603821 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,15278612 0,1629941 ! glucose catabolic process GO:0006007 88 56 0,000 0,15278612 0,16292295 ! RNA elongation GO:0006354 90 56 0,000 0,15278612 0,16285187 ! regulation of actin filament length GO:0030832 118 58 0,000 0,15779215 0,16811436 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,15779215 0,16804107 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,15779215 0,16796785 ! gastrulation GO:0007369 122 58 0,000 0,15779215 0,1678947 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,15779215 0,1678216 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,15779215 0,16774858 ! maintenance of location GO:0051235 124 58 0,000 0,15779215 0,16767561 ! nuclear export GO:0051168 110 59 0,000 0,16028417 0,17024967 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,16276889 0,17281373 ! DNA catabolic process GO:0006308 94 60 0,000 0,16276889 0,17273866 ! regulation of endocytosis GO:0030100 104 60 0,000 0,16276889 0,17266365 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,16276889 0,17258871 ! adult behavior GO:0030534 104 60 0,000 0,16276889 0,17251384 ! kidney development GO:0001822 133 60 0,000 0,16276889 0,17243903 ! positive regulation of secretion GO:0051047 110 61 0,000 0,16524632 0,17498776 ! regulation of cellular component size GO:0032535 125 61 0,000 0,16524632 0,17491194 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,16524632 0,17483619 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,16524632 0,1747605 ! regulation of heart contraction GO:0008016 123 61 0,000 0,16524632 0,17468488 ! camera-type eye development GO:0043010 126 61 0,000 0,16524632 0,17460933 ! proton transport GO:0015992 117 61 0,000 0,16524632 0,17453384 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,16524632 0,17445841 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,16771649 0,1769898 ! tRNA processing GO:0008033 102 62 0,000 0,16771649 0,17691338 ! mesoderm development GO:0007498 128 63 0,000 0,17017943 0,1794339 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,17017943 0,17935649 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,17017943 0,17927915 ! hydrogen transport GO:0006818 121 64 0,000 0,17263514 0,18178778 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,17263514 0,18170946 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,17263514 0,1816312 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,17508365 0,18412801 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,17508365 0,18404878 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,17508365 0,18396962 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,17508365 0,18389053 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,17508365 0,1838115 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,17752499 0,18629448 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,17752499 0,18621449 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,17995917 0,18868681 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,17995917 0,18860586 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,17995917 0,18852498 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,17995917 0,18844418 ! secondary metabolic process GO:0019748 125 67 0,000 0,17995917 0,18836344 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,18238622 0,19082207 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,18238622 0,19074038 ! hexose catabolic process GO:0019320 113 68 0,000 0,18238622 0,19065876 ! extracellular matrix organization GO:0030198 146 68 0,000 0,18238622 0,19057722 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,18238622 0,19049574 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,18238622 0,19041433 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,18238622 0,19033299 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,18238622 0,19025172 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,18480615 0,19269374 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,18480615 0,19261153 ! urogenital system development GO:0001655 149 69 0,000 0,18480615 0,19252939 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,18480615 0,19244732 ! single fertilization GO:0007338 83 69 0,000 0,18480615 0,19236533 ! cell redox homeostasis GO:0045454 114 70 0,000 0,18721899 0,19479386 ! activation of immune response GO:0002253 120 70 0,000 0,18721899 0,19471093 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,18721899 0,19462808 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,18962475 0,1970452 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,18962475 0,19696142 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,18962475 0,19687771 ! appendage morphogenesis GO:0035107 150 72 0,000 0,19202346 0,19928348 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,19202346 0,19919885 ! actin filament organization GO:0007015 167 72 0,000 0,19202346 0,19911431 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,19202346 0,19902983 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,19202346 0,19894542 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,19202346 0,19886109 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,19202346 0,19877682 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,19202346 0,19869263 ! appendage development GO:0048736 151 73 0,000 0,19441513 0,20108221 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,19441513 0,20099711 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,19441513 0,20091208 ! regulation of immune effector process GO:0002697 156 73 0,000 0,19441513 0,20082713 ! acute inflammatory response GO:0002526 118 74 0,000 0,1967998 0,20320452 ! amino acid transport GO:0006865 148 74 0,000 0,1967998 0,20311867 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,1967998 0,2030329 ! regulation of transcription factor activity GO:0051090 137 75 0,000 0,19917747 0,20539914 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 0,000 0,19917747 0,20531247 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,19917747 0,20522588 ! eye development GO:0001654 155 75 0,000 0,19917747 0,20513936 ! rhythmic process GO:0048511 142 75 0,000 0,19917747 0,20505291 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,20154817 0,20740614 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,20154817 0,20731881 ! learning or memory GO:0007611 161 76 0,000 0,20154817 0,20723156 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,20154817 0,20714437 ! regulation of blood pressure GO:0008217 134 76 0,000 0,20154817 0,20705726 ! amine catabolic process GO:0009310 136 77 0,000 0,20391192 0,20939757 ! neurotransmitter transport GO:0006836 142 77 0,000 0,20391192 0,20930959 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,20391192 0,20922168 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,20391192 0,20913384 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,20391192 0,20904608 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,20391192 0,20895839 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,20626873 0,21128491 ! antigen processing and presentation GO:0019882 117 78 0,000 0,20626873 0,21119636 ! fertilization GO:0009566 99 78 0,000 0,20626873 0,21110788 ! blood coagulation GO:0007596 151 79 0,000 0,20861864 0,21342351 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,20861864 0,21333417 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,20861864 0,21324491 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,20861864 0,21315573 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,20861864 0,21306661 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,21096166 0,21536955 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,21096166 0,21527959 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,21096166 0,2151897 ! muscle cell differentiation GO:0042692 178 81 0,000 0,2132978 0,21748186 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,2132978 0,21739113 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,21562709 0,21967347 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,21794956 0,22194696 ! exocytosis GO:0006887 153 83 0,000 0,21794956 0,22185449 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,21794956 0,22176209 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,21794956 0,22166976 ! response to metal ion GO:0010038 158 84 0,000 0,22026521 0,22393171 ! digestion GO:0007586 130 84 0,000 0,22026521 0,22383856 ! regulation of ligase activity GO:0051340 147 84 0,000 0,22026521 0,22374549 ! hemostasis GO:0007599 165 85 0,000 0,22257407 0,22599686 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,22257407 0,22590297 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,22257407 0,22580915 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,22257407 0,22571542 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,22487615 0,22795537 ! regulation of lyase activity GO:0051339 169 86 0,000 0,22487615 0,22786082 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,22717149 0,23009119 ! alcohol catabolic process GO:0046164 142 87 0,000 0,22717149 0,22999583 ! cellular respiration GO:0045333 143 88 0,000 0,22946009 0,23221666 ! amine biosynthetic process GO:0009309 146 88 0,000 0,22946009 0,2321205 ! sensory perception of smell GO:0007608 117 88 0,000 0,22946009 0,23202442 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,22946009 0,23192843 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,23174198 0,23413799 ! regulation of DNA binding GO:0051101 167 89 0,000 0,23174198 0,2340412 ! cellular defense response GO:0006968 123 89 0,000 0,23174198 0,23394449 ! regulation of neurological system process GO:0031644 175 89 0,000 0,23174198 0,23384786 ! response to inorganic substance GO:0010035 173 90 0,000 0,23401718 0,23604623 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,23401718 0,23594881 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,23401718 0,23585147 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,2362857 0,23803957 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,2362857 0,23794145 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,2408028 0,24239029 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,2408028 0,24229046 ! vitamin metabolic process GO:0006766 153 93 0,000 0,2408028 0,24219071 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,24305142 0,24435169 ! sterol metabolic process GO:0016125 166 94 0,000 0,24305142 0,24425118 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,24305142 0,24415075 ! regulation of defense response GO:0031347 171 95 0,000 0,24529344 0,24630163 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,24529344 0,24620044 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,24529344 0,24609933 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,24529344 0,2459983 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,24529344 0,24589736 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,24975776 0,25026998 ! transcription initiation GO:0006352 171 97 0,000 0,24975776 0,25016737 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,25198011 0,25228992 ! mRNA transport GO:0051028 185 100 0,000 0,25640525 0,25661534 ! positive regulation of immune response GO:0050778 175 100 0,000 0,25640525 0,25651025 ! hormone metabolic process GO:0042445 171 100 0,000 0,25640525 0,25640525