pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6541-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 87 43 9,000 7,051E-12 1,622E-08 ! interphase of mitotic cell cycle GO:0051329 156 86 11,000 3,218E-11 3,7E-08 ! interphase GO:0051325 159 88 11,000 4,251E-11 3,259E-08 ! protein sumoylation GO:0016925 12 10 5,000 1,413E-10 8,125E-08 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 4,000 1,549E-09 7,126E-07 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 4,000 9,152E-09 3,508E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 7,000 2,632E-08 8,647E-06 ! negative regulation of phosphorylation GO:0042326 41 23 5,000 6,128E-08 1,762E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 6,000 9,151E-08 2,339E-05 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 1,058E-07 2,434E-05 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of cell migration GO:0030335 92 51 6,000 5,203E-07 1,088E-04 ! negative regulation of DNA binding GO:0043392 54 33 5,000 6,212E-07 1,191E-04 ! positive regulation of cell motion GO:0051272 99 56 6,000 1,001E-06 1,772E-04 ! negative regulation of binding GO:0051100 58 36 5,000 1,067E-06 1,753E-04 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 1,132E-06 1,736E-04 ! negative regulation of kinase activity GO:0033673 100 58 6,000 1,278E-06 1,836E-04 ! regulation of protein localization GO:0032880 132 85 7,000 1,511E-06 2,044E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 1,613E-06 2,061E-04 ! negative regulation of transferase activity GO:0051348 105 61 6,000 1,81E-06 2,191E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 6,000 2,258E-06 2,597E-04 ! protein modification by small protein conjugation GO:0032446 140 90 7,000 2,337E-06 2,559E-04 ! peptidyl-amino acid modification GO:0018193 147 93 7,000 2,996E-06 3,133E-04 ! regulation of binding GO:0051098 151 95 7,000 3,519E-06 3,519E-04 ! protein modification by small protein conjugation or removal GO:0070647 148 96 7,000 3,808E-06 3,649E-04 ! protein amino acid autophosphorylation GO:0046777 80 45 5,000 4,155E-06 3,823E-04 ! negative regulation of transcription regulator activity GO:0090048 47 27 4,000 5,102E-06 4,513E-04 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of protein complex assembly GO:0031334 19 13 3,000 5,37E-06 4,575E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 5,37E-06 4,411E-04 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 2,000 8,443E-06 6,696E-04 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 2,000 8,443E-06 6,473E-04 ! peptidyl-threonine phosphorylation GO:0018107 14 5 2,000 8,443E-06 6,264E-04 ! regulation of DNA binding GO:0051101 119 77 6,000 8,776E-06 6,308E-04 ! peptidyl-serine phosphorylation GO:0018105 23 15 3,000 1,01E-05 7,04E-04 ! prostate gland development GO:0030850 9 6 2,000 1,677E-05 1,134E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 1,69E-05 1,11E-03 ! cell-substrate junction assembly GO:0007044 39 17 3,000 1,735E-05 1,108E-03 ! peptidyl-serine modification GO:0018209 27 17 3,000 1,735E-05 1,079E-03 ! cell cycle arrest GO:0007050 150 86 6,000 1,825E-05 1,104E-03 ! positive regulation of DNA replication GO:0045740 29 18 3,000 2,214E-05 1,306E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 2,214E-05 1,273E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 3,000 2,784E-05 1,562E-03 ! apoptotic nuclear changes GO:0030262 24 19 3,000 2,784E-05 1,524E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 2,914E-05 1,558E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 2,914E-05 1,523E-03 ! peptidyl-threonine modification GO:0018210 18 7 2,000 2,914E-05 1,489E-03 ! pigmentation GO:0043473 74 38 4,000 2,914E-05 1,457E-03 ! regulation of transcription factor activity GO:0051090 97 63 5,000 3,008E-05 1,472E-03 GO:0090046|regulation of transcription regulator activity, ! positive regulation of locomotion GO:0040017 35 20 3,000 3,454E-05 1,655E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 3,000 4,235E-05 1,988E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 4,629E-05 2,129E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 4,629E-05 2,088E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 4,629E-05 2,047E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 4,629E-05 2,009E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 5,137E-05 2,188E-03 ! glutamate signaling pathway GO:0007215 34 22 3,000 5,137E-05 2,148E-03 ! regulation of behavior GO:0050795 38 22 3,000 5,137E-05 2,11E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 6,173E-05 2,491E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 7,352E-05 2,916E-03 ! response to UV GO:0009411 75 46 4,000 7,482E-05 2,917E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 8,688E-05 3,33E-03 ! gland development GO:0048732 148 77 5,000 9,402E-05 3,545E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 9,78E-05 3,628E-03 ! negative regulation of protein modification process GO:0031400 50 26 3,000 1,019E-04 3,721E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 1,335E-04 4,799E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 24 11 2,000 1,335E-04 4,725E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 1,335E-04 4,653E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 1,335E-04 4,584E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,335E-04 4,517E-03 GO:0042130|negative regulation of T cell proliferation, ! cell junction assembly GO:0034329 56 28 3,000 1,375E-04 4,584E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 3,000 1,375E-04 4,518E-03 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 1,629E-04 5,276E-03 ! negative regulation of cell activation GO:0050866 44 30 3,000 1,813E-04 5,793E-03 ! negative regulation of response to stimulus GO:0048585 80 56 4,000 1,931E-04 6,083E-03 ! reproductive developmental process GO:0003006 127 89 5,000 2,097E-04 6,518E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 2,1E-04 6,44E-03 ! negative regulation of protein import into nucleus GO:0042308 25 13 2,000 2,282E-04 6,907E-03 ! cellular pigmentation GO:0033059 24 13 2,000 2,282E-04 6,817E-03 ! regulation of synaptic plasticity GO:0048167 52 32 3,000 2,344E-04 6,913E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 3,000 2,648E-04 7,709E-03 ! cell junction organization GO:0034330 63 33 3,000 2,648E-04 7,613E-03 ! nucleus organization GO:0006997 49 33 3,000 2,648E-04 7,519E-03 ! limbic system development GO:0021761 25 14 2,000 2,884E-04 8,09E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 2,884E-04 7,993E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 2,979E-04 8,156E-03 ! response to light stimulus GO:0009416 153 96 5,000 3,167E-04 8,569E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 3,338E-04 8,928E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 3,58E-04 9,465E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 3,58E-04 9,357E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 3,58E-04 9,252E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 3,58E-04 9,149E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! neutrophil chemotaxis GO:0030593 21 16 2,000 4,376E-04 0,01105903 ! regulation of neuron differentiation GO:0045664 107 67 4,000 4,486E-04 0,01121521 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 5,091E-04 0,01258982 ! cell growth GO:0016049 61 39 3,000 5,091E-04 0,01245589 ! memory GO:0007613 25 17 2,000 5,276E-04 0,01277339 ! regulation of viral genome replication GO:0045069 24 17 2,000 5,276E-04 0,01264033 ! inactivation of MAPK activity GO:0000188 27 17 2,000 5,276E-04 0,01251002 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 5,276E-04 0,01238237 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 5,276E-04 0,01225729 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 5,494E-04 0,01263669 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 5,615E-04 0,0127855 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 6,255E-04 0,01410433 GO:0045937|positive regulation of phosphate metabolic process, ! estrogen receptor signaling pathway GO:0030520 30 18 2,000 6,287E-04 0,01403865 ! regulation of glucose import GO:0046324 21 18 2,000 6,287E-04 0,01390367 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 6,287E-04 0,01377125 ! negative regulation of transport GO:0051051 116 73 4,000 6,664E-04 0,0144589 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 6,775E-04 0,01456345 ! response to alkaloid GO:0043279 32 19 2,000 7,413E-04 0,01578794 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 7,413E-04 0,0156431 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 7,413E-04 0,01550089 ! response to insulin stimulus GO:0032868 63 43 3,000 7,415E-04 0,01536424 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 8,096E-04 0,01662614 ! response to ethanol GO:0045471 37 20 2,000 8,661E-04 0,01762813 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 8,661E-04 0,0174735 ! pallium development GO:0021543 38 20 2,000 8,661E-04 0,01732156 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 8,661E-04 0,01717223 ! collagen catabolic process GO:0030574 25 20 2,000 8,661E-04 0,01702546 ! sleep GO:0030431 11 5 1,000 8,901E-04 0,0173498 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 8,901E-04 0,017204 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 8,901E-04 0,01706063 ! cerebral cortex radially oriented cell migration GO:0021799 8 5 1,000 8,901E-04 0,01691963 ! positive regulation of glycolysis GO:0045821 11 5 1,000 8,901E-04 0,01678095 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 8,901E-04 0,01664452 ! epithelial cell proliferation GO:0050673 6 5 1,000 8,901E-04 0,01651029 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 8,901E-04 0,01637821 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 8,901E-04 0,01624822 ! sister chromatid cohesion GO:0007062 9 5 1,000 8,901E-04 0,01612028 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 8,901E-04 0,01599434 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 8,901E-04 0,01587036 GO:0045686|negative regulation of glial cell differentiation, ! regulation of dendrite development GO:0050773 12 5 1,000 8,901E-04 0,01574828 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 8,901E-04 0,01562806 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 8,901E-04 0,01550967 ! regulation of respiratory burst GO:0060263 8 5 1,000 8,901E-04 0,01539305 ! apical protein localization GO:0045176 6 5 1,000 8,901E-04 0,01527818 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 8,901E-04 0,01516501 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 8,901E-04 0,0150535 ! regulation of sensory perception GO:0051931 6 5 1,000 8,901E-04 0,01494362 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 8,901E-04 0,01483533 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 8,901E-04 0,0147286 GO:0022011|myelination in the peripheral nervous system, ! cellular anion homeostasis GO:0030002 6 5 1,000 8,901E-04 0,0146234 GO:0055081|anion homeostasis, ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 1,003E-03 0,01636697 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 1,003E-03 0,01625171 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 1,003E-03 0,01613806 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 1,003E-03 0,01602599 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 1,04E-03 0,01650298 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA replication GO:0006275 75 48 3,000 1,127E-03 0,01774814 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 1,154E-03 0,01805079 GO:0010810|regulation of cell-substrate adhesion, ! regulation of intracellular transport GO:0032386 78 49 3,000 1,218E-03 0,0189241 ! positive regulation of growth GO:0045927 67 50 3,000 1,314E-03 0,02028109 ! myelination GO:0042552 35 23 2,000 1,317E-03 0,02020126 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,317E-03 0,02006748 ! regulation of viral reproduction GO:0050792 32 23 2,000 1,317E-03 0,01993546 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,327E-03 0,01994531 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,327E-03 0,01981579 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 1,327E-03 0,01968795 GO:0031958|corticosteroid receptor signaling pathway, ! glucocorticoid metabolic process GO:0008211 7 6 1,000 1,327E-03 0,01956175 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 1,000 1,327E-03 0,01943715 ! pigment granule organization GO:0048753 11 6 1,000 1,327E-03 0,01931413 ! ER overload response GO:0006983 7 6 1,000 1,327E-03 0,01919266 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,327E-03 0,0190727 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,327E-03 0,01895424 ! male sex determination GO:0030238 9 6 1,000 1,327E-03 0,01883724 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 1,327E-03 0,01872167 ! astrocyte development GO:0014002 14 6 1,000 1,327E-03 0,01860751 ! DNA topological change GO:0006265 8 6 1,000 1,327E-03 0,01849474 ! Schwann cell development GO:0014044 14 6 1,000 1,327E-03 0,01838333 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,327E-03 0,01827325 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,327E-03 0,01816448 ! regulation of membrane potential GO:0042391 128 85 4,000 1,328E-03 0,01806834 ! fat cell differentiation GO:0045444 37 24 2,000 1,495E-03 0,02022892 ! negative regulation of cell development GO:0010721 56 24 2,000 1,495E-03 0,02011062 GO:0050768|negative regulation of neurogenesis, ! regulation of JUN kinase activity GO:0043506 34 24 2,000 1,495E-03 0,0199937 ! regulation of neurogenesis GO:0050767 153 89 4,000 1,629E-03 0,02166366 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,687E-03 0,02230236 ! regulation of protein complex assembly GO:0043254 81 54 3,000 1,752E-03 0,02302191 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 1,846E-03 0,02412205 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 1,846E-03 0,02398577 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,846E-03 0,02385102 ! cerebral cortex cell migration GO:0021795 11 7 1,000 1,846E-03 0,02371777 ! microtubule bundle formation GO:0001578 8 7 1,000 1,846E-03 0,023586 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,846E-03 0,02345569 ! asymmetric protein localization GO:0008105 8 7 1,000 1,846E-03 0,02332682 ! organ growth GO:0035265 11 7 1,000 1,846E-03 0,02319935 ! behavioral fear response GO:0001662 13 7 1,000 1,846E-03 0,02307327 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 1,846E-03 0,02294854 ! response to UV-B GO:0010224 11 7 1,000 1,846E-03 0,02282517 ! B cell lineage commitment GO:0002326 17 7 1,000 1,846E-03 0,02270311 ! T cell lineage commitment GO:0002360 12 7 1,000 1,846E-03 0,02258234 ! neuroblast proliferation GO:0007405 13 7 1,000 1,846E-03 0,02246286 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,846E-03 0,02234464 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 1,846E-03 0,02222765 ! multicellular organismal catabolic process GO:0044243 32 26 2,000 1,894E-03 0,02268856 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,894E-03 0,022571 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 2,116E-03 0,02508551 ! negative regulation of protein transport GO:0051224 49 27 2,000 2,116E-03 0,02495686 ! chromosome segregation GO:0007059 83 57 3,000 2,14E-03 0,02511207 ! regulation of cellular component biogenesis GO:0044087 158 96 4,000 2,275E-03 0,02655925 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 2,282E-03 0,02650354 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 2,353E-03 0,02719912 ! ensheathment of neurons GO:0007272 43 28 2,000 2,353E-03 0,02706313 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 2,000 2,353E-03 0,02692848 ! lung development GO:0030324 94 59 3,000 2,43E-03 0,02766332 ! actin filament organization GO:0007015 95 59 3,000 2,43E-03 0,02752705 ! cell proliferation in forebrain GO:0021846 10 8 1,000 2,446E-03 0,02757428 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,446E-03 0,02743977 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,446E-03 0,02730657 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,446E-03 0,02717465 ! middle ear morphogenesis GO:0042474 9 8 1,000 2,446E-03 0,027044 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,446E-03 0,02691461 ! astrocyte differentiation GO:0048708 16 8 1,000 2,446E-03 0,02678644 ! melanin metabolic process GO:0006582 12 8 1,000 2,446E-03 0,02665949 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 2,446E-03 0,02653374 ! Schwann cell differentiation GO:0014037 17 8 1,000 2,446E-03 0,02640917 ! regulation of gliogenesis GO:0014013 20 8 1,000 2,446E-03 0,02628576 GO:0045685|regulation of glial cell differentiation, ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,446E-03 0,0261635 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 1,000 2,446E-03 0,02604237 ! hormone catabolic process GO:0042447 13 8 1,000 2,446E-03 0,02592236 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,446E-03 0,02580345 ! regulation of embryonic development GO:0045995 16 8 1,000 2,446E-03 0,02568563 ! regulation of homeostatic process GO:0032844 105 60 3,000 2,584E-03 0,02701434 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 2,602E-03 0,027077 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 2,607E-03 0,02700513 ! telencephalon development GO:0021537 52 29 2,000 2,607E-03 0,02688403 ! urogenital system development GO:0001655 101 61 3,000 2,745E-03 0,02818534 ! collagen metabolic process GO:0032963 40 30 2,000 2,876E-03 0,02939966 ! hindbrain development GO:0030902 45 30 2,000 2,876E-03 0,02926957 ! negative regulation of cell growth GO:0030308 106 62 3,000 2,913E-03 0,02951272 ! respiratory tube development GO:0030323 99 62 3,000 2,913E-03 0,02938328 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 3,087E-03 0,03100911 ! regulation of developmental growth GO:0048638 13 9 1,000 3,125E-03 0,03124797 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,125E-03 0,03111269 ! telencephalon cell migration GO:0022029 16 9 1,000 3,125E-03 0,03097859 ! regulation of glycolysis GO:0006110 15 9 1,000 3,125E-03 0,03084563 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 3,125E-03 0,03071381 ! T cell selection GO:0045058 18 9 1,000 3,125E-03 0,03058312 ! indolalkylamine metabolic process GO:0006586 14 9 1,000 3,125E-03 0,03045353 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! substrate-bound cell migration GO:0006929 10 9 1,000 3,125E-03 0,03032503 ! epithelial cell development GO:0002064 10 9 1,000 3,125E-03 0,03019761 ! motor axon guidance GO:0008045 14 9 1,000 3,125E-03 0,03007126 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 3,125E-03 0,02994597 ! DNA ligation GO:0006266 14 9 1,000 3,125E-03 0,02982171 ! response to amine stimulus GO:0014075 13 9 1,000 3,125E-03 0,02969848 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 3,125E-03 0,02957626 ! oocyte differentiation GO:0009994 12 9 1,000 3,125E-03 0,02945505 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 3,125E-03 0,02933483 ! spleen development GO:0048536 15 9 1,000 3,125E-03 0,02921558 ! blastocyst formation GO:0001825 12 9 1,000 3,125E-03 0,0290973 ! embryonic placenta development GO:0001892 12 9 1,000 3,125E-03 0,02897997 ! response to nicotine GO:0035094 16 9 1,000 3,125E-03 0,02886358 ! localization within membrane GO:0051668 15 9 1,000 3,125E-03 0,02874813 ! leukocyte chemotaxis GO:0030595 43 31 2,000 3,162E-03 0,02897505 GO:0060326|cell chemotaxis, ! cell cycle checkpoint GO:0000075 108 64 3,000 3,269E-03 0,02983699 ! negative regulation of cell size GO:0045792 108 64 3,000 3,269E-03 0,02971906 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 3,269E-03 0,02960206 ! respiratory system development GO:0060541 100 64 3,000 3,269E-03 0,02948597 ! reproductive structure development GO:0048608 90 65 3,000 3,458E-03 0,03106721 ! peripheral nervous system development GO:0007422 53 32 2,000 3,465E-03 0,03100899 ! regulation of protein stability GO:0031647 48 32 2,000 3,465E-03 0,0308888 ! carbohydrate homeostasis GO:0033500 39 33 2,000 3,785E-03 0,03361134 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 2,000 3,785E-03 0,03348207 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 3,882E-03 0,03420519 ! hair follicle morphogenesis GO:0031069 17 10 1,000 3,882E-03 0,03407463 ! hippocampus development GO:0021766 19 10 1,000 3,882E-03 0,03394507 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 3,882E-03 0,03381649 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 3,882E-03 0,03368888 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 3,882E-03 0,03356223 ! B cell proliferation GO:0042100 14 10 1,000 3,882E-03 0,03343653 ! forebrain cell migration GO:0021885 17 10 1,000 3,882E-03 0,03331177 ! fear response GO:0042596 16 10 1,000 3,882E-03 0,03318793 ! negative regulation of ossification GO:0030279 19 10 1,000 3,882E-03 0,03306501 ! alpha-beta T cell activation GO:0046631 16 10 1,000 3,882E-03 0,032943 ! cranial nerve development GO:0021545 12 10 1,000 3,882E-03 0,03282189 ! DNA methylation GO:0006306 15 10 1,000 3,882E-03 0,03270166 GO:0006305|DNA alkylation, ! positive regulation of viral reproduction GO:0048524 15 10 1,000 3,882E-03 0,03258231 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 3,882E-03 0,03246383 GO:0043470|regulation of carbohydrate catabolic process, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 3,882E-03 0,03234621 ! learning or memory GO:0007611 123 68 3,000 4,069E-03 0,0337826 ! regulation of neuron projection development GO:0010975 63 34 2,000 4,122E-03 0,03410607 ! development of primary male sexual characteristics GO:0046546 44 34 2,000 4,122E-03 0,03398383 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 4,122E-03 0,03386245 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 2,000 4,122E-03 0,03374195 ! response to drug GO:0042493 108 69 3,000 4,287E-03 0,03496765 ! regulation of action potential in neuron GO:0019228 54 35 2,000 4,478E-03 0,03639009 ! virus-host interaction GO:0019048 17 11 1,000 4,714E-03 0,03818029 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,714E-03 0,03804633 ! detection of mechanical stimulus GO:0050982 15 11 1,000 4,714E-03 0,0379133 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 4,714E-03 0,0377812 ! mitotic spindle organization GO:0007052 15 11 1,000 4,714E-03 0,03765001 ! T cell homeostasis GO:0043029 20 11 1,000 4,714E-03 0,03751974 ! male genitalia development GO:0030539 13 11 1,000 4,714E-03 0,03739036 ! digestive tract morphogenesis GO:0048546 15 11 1,000 4,714E-03 0,03726187 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! actin filament polymerization GO:0030041 17 11 1,000 4,714E-03 0,03713426 ! phosphoinositide-mediated signaling GO:0048015 109 71 3,000 4,748E-03 0,03727371 ! response to reactive oxygen species GO:0000302 55 36 2,000 4,851E-03 0,03794785 ! response to hypoxia GO:0001666 132 72 3,000 4,991E-03 0,03891185 ! regulation of synaptic transmission GO:0050804 109 72 3,000 4,991E-03 0,03878039 ! mitochondrion organization GO:0007005 104 73 3,000 5,242E-03 0,04059123 ! learning GO:0007612 67 37 2,000 5,242E-03 0,04045934 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 5,501E-03 0,04231196 ! response to oxygen levels GO:0070482 137 74 3,000 5,501E-03 0,04217092 ! negative regulation of cell projection organization GO:0031345 26 12 1,000 5,622E-03 0,04295853 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 5,622E-03 0,04281628 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 5,622E-03 0,04267497 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 5,622E-03 0,0425346 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 5,622E-03 0,04239514 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 5,622E-03 0,04225659 ! autonomic nervous system development GO:0048483 23 12 1,000 5,622E-03 0,04211895 ! gland morphogenesis GO:0022612 23 12 1,000 5,622E-03 0,0419822 ! peptidyl-lysine modification GO:0018205 18 12 1,000 5,622E-03 0,04184633 ! response to gamma radiation GO:0010332 20 12 1,000 5,622E-03 0,04171135 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 5,622E-03 0,04157723 ! regulation of T cell proliferation GO:0042129 58 38 2,000 5,652E-03 0,04166537 ! negative regulation of growth GO:0045926 123 75 3,000 5,768E-03 0,04238439 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 6,044E-03 0,04427064 ! regulation of protein transport GO:0051223 114 76 3,000 6,044E-03 0,0441301 GO:0070201|regulation of establishment of protein localization, ! multicellular organismal metabolic process GO:0044236 50 39 2,000 6,081E-03 0,04425735 ! male sex differentiation GO:0046661 53 39 2,000 6,081E-03 0,04411774 ! sex differentiation GO:0007548 105 77 3,000 6,328E-03 0,04577214 ! regulation of transmission of nerve impulse GO:0051969 116 77 3,000 6,328E-03 0,04562865 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 6,603E-03 0,0474565 ! regulation of transmembrane transporter activity GO:0022898 19 13 1,000 6,603E-03 0,04730866 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 6,603E-03 0,04716174 ! genitalia development GO:0048806 15 13 1,000 6,603E-03 0,04701573 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 6,603E-03 0,04687062 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 1,000 6,603E-03 0,0467264 ! lymphocyte homeostasis GO:0002260 24 13 1,000 6,603E-03 0,04658307 ! positive regulation of protein modification process GO:0031401 107 78 3,000 6,622E-03 0,04657571 ! regulation of T cell differentiation GO:0045580 59 41 2,000 6,995E-03 0,04904814 ! regulation of JNK cascade GO:0046328 58 41 2,000 6,995E-03 0,04889906 ! forebrain development GO:0030900 131 80 3,000 7,235E-03 0,05042787 ! cellular component disassembly GO:0022411 64 42 2,000 7,481E-03 0,0519802 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 2,000 7,481E-03 0,05182363 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 7,481E-03 0,051668 ! regulation of neurological system process GO:0031644 122 81 3,000 7,556E-03 0,05202972 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 7,655E-03 0,0525568 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 7,655E-03 0,05240038 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 7,655E-03 0,05224489 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 7,655E-03 0,05209032 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 7,655E-03 0,05193666 ! heterophilic cell adhesion GO:0007157 29 14 1,000 7,655E-03 0,0517839 ! startle response GO:0001964 21 14 1,000 7,655E-03 0,05163204 ! epidermis morphogenesis GO:0048730 29 14 1,000 7,655E-03 0,05148107 ! pituitary gland development GO:0021983 23 14 1,000 7,655E-03 0,05133098 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 7,655E-03 0,05118176 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 7,655E-03 0,05103341 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 7,655E-03 0,05088592 ! negative regulation of blood coagulation GO:0030195 19 14 1,000 7,655E-03 0,05073927 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 7,655E-03 0,05059347 ! leukocyte migration GO:0050900 60 43 2,000 7,986E-03 0,05263022 ! activation of caspase activity GO:0006919 65 43 2,000 7,986E-03 0,05247985 ! regulation of cell adhesion GO:0030155 159 83 3,000 8,224E-03 0,05388926 ! regulation of cell projection organization GO:0031344 83 44 2,000 8,511E-03 0,05561275 ! glycolysis GO:0006096 53 44 2,000 8,511E-03 0,05545521 ! regulation of action potential GO:0001508 71 44 2,000 8,511E-03 0,05529856 ! negative regulation of cell migration GO:0030336 92 44 2,000 8,511E-03 0,05514279 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 8,511E-03 0,05498789 ! regulation of inflammatory response GO:0050727 60 44 2,000 8,511E-03 0,05483386 ! metencephalon development GO:0022037 19 15 1,000 8,778E-03 0,05639257 ! lipid phosphorylation GO:0046834 23 15 1,000 8,778E-03 0,05623549 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 1,000 8,778E-03 0,05607928 ! regulation of survival gene product expression GO:0045884 20 15 1,000 8,778E-03 0,05592393 ! cerebral cortex development GO:0021987 29 15 1,000 8,778E-03 0,05576945 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 8,778E-03 0,05561581 ! dopamine metabolic process GO:0042417 30 15 1,000 8,778E-03 0,05546302 ! defense response to virus GO:0051607 27 15 1,000 8,778E-03 0,05531107 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 8,778E-03 0,05515995 ! positive regulation of cell cycle GO:0045787 77 45 2,000 9,056E-03 0,05675489 ! positive regulation of defense response GO:0031349 59 45 2,000 9,056E-03 0,05660066 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 9,969E-03 0,0621378 ! protein amino acid acetylation GO:0006473 28 16 1,000 9,969E-03 0,06196986 ! glial cell development GO:0021782 24 16 1,000 9,969E-03 0,06180283 ! cellular response to unfolded protein GO:0034620 19 16 1,000 9,969E-03 0,06163669 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 1,000 9,969E-03 0,06147145 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 9,969E-03 0,06130709 ! DNA replication initiation GO:0006270 25 16 1,000 9,969E-03 0,0611436 ! diencephalon development GO:0021536 25 16 1,000 9,969E-03 0,06098098 ! oogenesis GO:0048477 23 16 1,000 9,969E-03 0,06081923 ! G1 phase GO:0051318 27 16 1,000 9,969E-03 0,06065833 ! steroid catabolic process GO:0006706 22 16 1,000 9,969E-03 0,06049828 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 9,969E-03 0,06033908 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 9,969E-03 0,06018071 ! nerve development GO:0021675 18 16 1,000 9,969E-03 0,06002317 ! negative regulation of immune system process GO:0002683 73 47 2,000 0,01020607 0,0612897 ! positive regulation of caspase activity GO:0043280 72 48 2,000 0,01081136 0,06475556 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 0,01081136 0,06458737 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 0,01081136 0,06442004 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 0,01122793 0,06672929 ! actin polymerization or depolymerization GO:0008154 31 17 1,000 0,01122793 0,0665573 ! actin filament bundle formation GO:0051017 26 17 1,000 0,01122793 0,0663862 ! neuromuscular junction development GO:0007528 23 17 1,000 0,01122793 0,06621598 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 0,01122793 0,06604663 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 0,01122793 0,06587815 ! negative regulation of coagulation GO:0050819 23 17 1,000 0,01122793 0,06571052 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 0,01143704 0,06676442 ! cartilage development GO:0051216 70 49 2,000 0,01143704 0,0665954 ! ear development GO:0043583 72 50 2,000 0,0120832 0,07018018 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 0,0120832 0,0700034 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 0,01255283 0,0725415 ! axis specification GO:0009798 26 18 1,000 0,01255283 0,07235969 ! pigmentation during development GO:0048066 31 18 1,000 0,01255283 0,07217879 ! visual learning GO:0008542 35 18 1,000 0,01255283 0,07199879 ! somitogenesis GO:0001756 24 18 1,000 0,01255283 0,07181969 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 0,01255283 0,07164148 ! activation of JUN kinase activity GO:0007257 23 18 1,000 0,01255283 0,07146415 ! gut development GO:0048565 26 18 1,000 0,01255283 0,07128769 ! activation of phospholipase C activity GO:0007202 87 51 2,000 0,01274995 0,07222876 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cell motion GO:0051271 104 51 2,000 0,01274995 0,0720513 ! positive regulation of phospholipase activity GO:0010518 88 52 2,000 0,01343738 0,07574995 ! aging GO:0007568 79 52 2,000 0,01343738 0,07556475 ! regulation of response to external stimulus GO:0032101 139 96 3,000 0,01352036 0,0758459 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 0,01394242 0,07802327 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 0,01394242 0,07783389 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,01394242 0,07764543 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 1,000 0,01394242 0,07745788 ! regeneration GO:0031099 32 19 1,000 0,01394242 0,07727124 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 0,01394242 0,07708549 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01394242 0,07690063 ! sex determination GO:0007530 29 19 1,000 0,01394242 0,07671666 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,01394242 0,07653357 ! renal system process GO:0003014 35 19 1,000 0,01394242 0,07635134 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 0,01394242 0,07616999 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 0,01394242 0,07598949 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 0,01394242 0,07580984 ! skeletal system morphogenesis GO:0048705 78 53 2,000 0,01414559 0,07673315 ! glucose catabolic process GO:0006007 66 54 2,000 0,01487464 0,08049807 ! regulation of phospholipase activity GO:0010517 90 54 2,000 0,01487464 0,08030911 ! cytokine-mediated signaling pathway GO:0019221 76 54 2,000 0,01487464 0,08012103 ! DNA catabolic process GO:0006308 67 54 2,000 0,01487464 0,07993384 ! positive regulation of lipase activity GO:0060193 90 54 2,000 0,01487464 0,07974751 ! extracellular structure organization GO:0043062 156 99 3,000 0,01498983 0,08017814 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01539535 0,08215614 ! chromosome condensation GO:0030261 31 20 1,000 0,01539535 0,08196596 ! DNA modification GO:0006304 28 20 1,000 0,01539535 0,08177667 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01539535 0,08158824 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01691029 0,08941074 ! dendrite development GO:0016358 35 21 1,000 0,01691029 0,08920567 ! visual behavior GO:0007632 39 21 1,000 0,01691029 0,08900153 ! regulation of DNA recombination GO:0000018 40 21 1,000 0,01691029 0,08879833 ! ovarian follicle development GO:0001541 30 21 1,000 0,01691029 0,08859606 ! cell aging GO:0007569 32 21 1,000 0,01691029 0,0883947 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 1,000 0,01691029 0,08819426 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01691029 0,08799473 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01691029 0,08779609 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01691029 0,08759836 ! multicellular organism reproduction GO:0032504 83 57 2,000 0,01718754 0,08883447 GO:0048609|reproductive process in a multicellular organism, ! viral reproductive process GO:0022415 87 58 2,000 0,01800059 0,09282815 ! viral genome replication GO:0019079 29 22 1,000 0,01848595 0,09511788 ! regulation of transmembrane transport GO:0034762 30 22 1,000 0,01848595 0,09490556 ! leukocyte adhesion GO:0007159 38 22 1,000 0,01848595 0,09469419 ! molting cycle process GO:0022404 40 22 1,000 0,01848595 0,09448376 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01848595 0,09427426 ! vasculogenesis GO:0001570 33 22 1,000 0,01848595 0,09406569 ! ureteric bud development GO:0001657 32 22 1,000 0,01848595 0,09385804 ! membrane depolarization GO:0051899 35 22 1,000 0,01848595 0,0936513 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01848595 0,09344547 ! regulation of blood coagulation GO:0030193 34 22 1,000 0,01848595 0,09324055 ! blastocyst development GO:0001824 37 22 1,000 0,01848595 0,09303652 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 0,01848595 0,09283339 ! protein tetramerization GO:0051262 39 22 1,000 0,01848595 0,09263113 ! activation of MAPK activity GO:0000187 84 59 2,000 0,01883475 0,09417376 ! regulation of heart contraction GO:0008016 91 60 2,000 0,01969005 0,09823672 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,02012105 0,10016971 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,02012105 0,09995336 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,02012105 0,09973794 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,02012105 0,09952345 ! interaction with host GO:0051701 37 23 1,000 0,02012105 0,09930988 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,02012105 0,09909723 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,02012105 0,09888548 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,02012105 0,09867464 ! regulation of cellular response to stress GO:0080135 85 61 2,000 0,02056652 0,10064469 ! meiosis GO:0007126 96 61 2,000 0,02056652 0,100431 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 0,02056652 0,10021823 ! extracellular matrix organization GO:0030198 103 61 2,000 0,02056652 0,10000635 ! meiotic cell cycle GO:0051321 97 62 2,000 0,02146417 0,10415104 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,02181431 0,10562717 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,02181431 0,10540526 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,02181431 0,10518428 ! response to toxin GO:0009636 38 24 1,000 0,02181431 0,10496423 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,02181431 0,1047451 ! viral reproduction GO:0016032 92 63 2,000 0,02238301 0,10725191 ! regulation of lipase activity GO:0060191 109 63 2,000 0,02238301 0,10702894 ! hexose catabolic process GO:0019320 82 64 2,000 0,02332304 0,1112925 ! male gonad development GO:0008584 33 25 1,000 0,02356449 0,11221184 ! iron ion homeostasis GO:0055072 39 25 1,000 0,02356449 0,11198 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,02356449 0,11174911 ! leukocyte proliferation GO:0070661 39 25 1,000 0,02356449 0,11151918 GO:0032943|mononuclear cell proliferation, ! regulation of caspase activity GO:0043281 97 65 2,000 0,02428425 0,11468949 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 0,02428425 0,11445447 ! protein oligomerization GO:0051259 100 65 2,000 0,02428425 0,11422041 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,02526664 0,11859853 ! axon guidance GO:0007411 99 66 2,000 0,02526664 0,11835699 ! post-embryonic development GO:0009791 42 26 1,000 0,02537036 0,11860128 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,02537036 0,11836071 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,02537036 0,11812111 ! regulation of coagulation GO:0050818 39 26 1,000 0,02537036 0,11788249 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,0262702 0,12181744 ! catechol metabolic process GO:0009712 43 27 1,000 0,02723072 0,1260174 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! response to ionizing radiation GO:0010212 47 27 1,000 0,02723072 0,12576436 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02723072 0,12551232 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,02729488 0,12555647 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,02914436 0,13379648 ! phenol metabolic process GO:0018958 44 28 1,000 0,02914436 0,13352995 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02914436 0,13326449 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,02914436 0,13300007 ! placenta development GO:0001890 37 28 1,000 0,02914436 0,13273671 ! response to metal ion GO:0010038 103 70 2,000 0,02940755 0,1336707 ! regulation of catabolic process GO:0009894 106 70 2,000 0,02940755 0,13340705 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,03049546 0,13807 ! monosaccharide catabolic process GO:0046365 91 71 2,000 0,03049546 0,13779874 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,03111013 0,14030056 ! ovulation cycle process GO:0022602 41 29 1,000 0,03111013 0,140026 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,03111013 0,13975252 ! tissue homeostasis GO:0001894 42 29 1,000 0,03111013 0,13948009 GO:0048871|multicellular organismal homeostasis, ! regulation of peptidase activity GO:0052547 106 72 2,000 0,03160436 0,14142027 ! tube morphogenesis GO:0035239 118 73 2,000 0,03273419 0,14619153 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,03312684 0,14765842 ! spindle organization GO:0007051 37 30 1,000 0,03312684 0,14737281 ! ovulation cycle GO:0042698 43 30 1,000 0,03312684 0,14708831 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,03312684 0,1468049 ! response to heat GO:0009408 41 30 1,000 0,03312684 0,14652258 ! response to inorganic substance GO:0010035 115 75 2,000 0,03505645 0,15475974 ! regulation of ligase activity GO:0051340 114 75 2,000 0,03505645 0,15446327 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,03519338 0,15477013 ! mammary gland development GO:0030879 57 31 1,000 0,03519338 0,15447477 ! glial cell differentiation GO:0010001 55 31 1,000 0,03519338 0,15418053 ! odontogenesis GO:0042476 50 31 1,000 0,03519338 0,15388741 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,03519338 0,1535954 ! segmentation GO:0035282 41 31 1,000 0,03519338 0,1533045 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,03519338 0,1530147 ! metanephros development GO:0001656 58 31 1,000 0,03519338 0,15272599 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03519338 0,15243837 ! regulation of muscle development GO:0048634 48 32 1,000 0,03730861 0,16129663 ! meiosis I GO:0007127 52 32 1,000 0,03730861 0,16099401 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,03730861 0,16069252 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,03730861 0,16039216 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,03947143 0,16937368 ! ear morphogenesis GO:0042471 42 33 1,000 0,03947143 0,16905827 ! actomyosin structure organization GO:0031032 43 33 1,000 0,03947143 0,16874403 ! female gonad development GO:0008585 49 33 1,000 0,03947143 0,16843097 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03947143 0,16811906 ! alcohol catabolic process GO:0046164 104 80 2,000 0,04122403 0,17525926 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,04168075 0,17687401 ! neuron migration GO:0001764 46 34 1,000 0,04168075 0,17654828 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,04168075 0,17622374 ! female gamete generation GO:0007292 43 34 1,000 0,04168075 0,1759004 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,04251896 0,17910919 ! response to protein stimulus GO:0051789 111 81 2,000 0,04251896 0,17878175 ! ossification GO:0001503 134 82 2,000 0,04383417 0,18397554 GO:0060348|bone development, ! maintenance of protein location GO:0045185 65 35 1,000 0,04393548 0,18406487 ! glycogen metabolic process GO:0005977 48 35 1,000 0,04393548 0,18373021 ! pigment metabolic process GO:0042440 61 35 1,000 0,04393548 0,18339676 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,04393548 0,18306452 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,04393548 0,18273348 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04623459 0,19194865 GO:0090047|positive regulation of transcription regulator activity, ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04623459 0,1916028 GO:0046660|female sex differentiation, ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,04623459 0,19125819 ! glucan metabolic process GO:0044042 49 36 1,000 0,04623459 0,19091481 GO:0006073|cellular glucan metabolic process, ! regulation of defense response GO:0031347 117 84 2,000 0,04652501 0,19176976 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,04652501 0,1914267 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04686481 0,19248048 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04686481 0,19213737 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04686481 0,19179549 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04686481 0,19145482 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04686481 0,19111537 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04686481 0,19077711 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04686481 0,19044005 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04686481 0,19010417 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04686481 0,18976948 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04686481 0,18943597 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04686481 0,18910362 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04686481 0,18877244 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04686481 0,18844242 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04686481 0,18811355 ! tongue development GO:0043586 6 5 0,000 0,04686481 0,18778583 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04686481 0,18745925 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04686481 0,1871338 ! cobalt ion transport GO:0006824 9 5 0,000 0,04686481 0,18680947 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04686481 0,18648627 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04686481 0,18616419 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04686481 0,18584322 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04686481 0,18552335 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04686481 0,18520458 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04686481 0,18488691 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04686481 0,18457032 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04686481 0,18425481 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04686481 0,18394039 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04686481 0,18362703 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04686481 0,18331474 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04686481 0,18300351 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04686481 0,18269333 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04686481 0,18238421 ! malate metabolic process GO:0006108 7 5 0,000 0,04686481 0,18207613 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04686481 0,18176908 ! behavioral response to pain GO:0048266 7 5 0,000 0,04686481 0,18146307 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04686481 0,18115809 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04686481 0,18085414 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04686481 0,1805512 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! mating behavior GO:0007617 6 5 0,000 0,04686481 0,18024927 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04686481 0,17994836 ! rhythmic behavior GO:0007622 12 5 0,000 0,04686481 0,17964844 ! copulation GO:0007620 7 5 0,000 0,04686481 0,17934953 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04686481 0,1790516 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04686481 0,17875467 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04686481 0,17845872 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04686481 0,17816375 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04686481 0,17786975 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04686481 0,17757672 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04686481 0,17728465 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04686481 0,17699354 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04686481 0,17670339 ! response to protozoan GO:0001562 9 5 0,000 0,04686481 0,17641418 ! lymph vessel development GO:0001945 7 5 0,000 0,04686481 0,17612592 ! endochondral ossification GO:0001958 12 5 0,000 0,04686481 0,17583861 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04686481 0,17555222 ! parathyroid gland development GO:0060017 8 5 0,000 0,04686481 0,17526677 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04686481 0,17498225 ! anagen GO:0042640 6 5 0,000 0,04686481 0,17469865 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04686481 0,17441596 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04686481 0,17413419 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04686481 0,17385333 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04686481 0,17357338 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04686481 0,17329432 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04686481 0,17301616 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04686481 0,17273889 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04686481 0,17246251 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04686481 0,17218701 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04686481 0,17191239 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04686481 0,17163864 ! ovulation GO:0030728 6 5 0,000 0,04686481 0,17136576 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04686481 0,17109376 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,04686481 0,17082261 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,04686481 0,17055232 ! response to pH GO:0009268 9 5 0,000 0,04686481 0,17028288 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04686481 0,1700143 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04686481 0,16974656 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04686481 0,16947966 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04686481 0,1692136 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04686481 0,16894838 ! polyol catabolic process GO:0046174 7 5 0,000 0,04686481 0,16868398 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04686481 0,16842042 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04686481 0,16815767 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04686481 0,16789574 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04686481 0,16763463 ! urea metabolic process GO:0019627 6 5 0,000 0,04686481 0,16737433 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04686481 0,16711483 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04686481 0,16685614 ! neutrophil activation GO:0042119 5 5 0,000 0,04686481 0,16659825 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04686481 0,16634115 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04686481 0,16608485 ! response to food GO:0032094 5 5 0,000 0,04686481 0,16582933 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04686481 0,1655746 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04686481 0,16532065 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04686481 0,16506748 ! forebrain neuron development GO:0021884 7 5 0,000 0,04686481 0,16481509 ! melanosome organization GO:0032438 7 5 0,000 0,04686481 0,16456346 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04686481 0,1643126 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04686481 0,16406251 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04686481 0,16381317 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04686481 0,16356459 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04686481 0,16331677 ! nucleoside transport GO:0015858 6 5 0,000 0,04686481 0,16306969 ! nucleoside salvage GO:0043174 7 5 0,000 0,04686481 0,16282336 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04686481 0,16257778 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04686481 0,16233293 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04686481 0,16208882 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04686481 0,16184544 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04686481 0,1616028 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04686481 0,16136088 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04686481 0,16111968 ! depyrimidination GO:0045008 8 5 0,000 0,04686481 0,1608792 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04686481 0,16063944 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04686481 0,1604004 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04686481 0,16016206 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04686481 0,15992443 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04686481 0,15968751 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04686481 0,15945128 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04686481 0,15921575 ! monocyte differentiation GO:0030224 8 5 0,000 0,04686481 0,15898092 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04686481 0,15874678 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04686481 0,15851333 ! centrosome duplication GO:0051298 5 5 0,000 0,04686481 0,15828057 ! response to UV-C GO:0010225 6 5 0,000 0,04686481 0,15804848 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04686481 0,15781708 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04686481 0,15758635 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04686481 0,1573563 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04686481 0,15712692 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04686481 0,1568982 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04686481 0,15667015 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04686481 0,15644277 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04686481 0,15621604 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04686481 0,15598997 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04686481 0,15576455 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04686481 0,15553978 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04686481 0,15531566 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04686481 0,15509218 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04686481 0,15486935 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04686481 0,15464715 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04686481 0,1544256 ! neural tube patterning GO:0021532 6 5 0,000 0,04686481 0,15420467 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04686481 0,15398438 ! histone demethylation GO:0016577 9 5 0,000 0,04686481 0,15376472 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04686481 0,15354568 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04686481 0,15332726 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04686481 0,15310947 ! enteric nervous system development GO:0048484 8 5 0,000 0,04686481 0,15289229 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04686481 0,15267573 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04686481 0,15245978 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04686481 0,15224444 ! transcription termination GO:0006353 8 5 0,000 0,04686481 0,15202971 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04686481 0,15181559 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04686481 0,15160206 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04686481 0,15138914 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04686481 0,15117681 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04686481 0,15096508 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04686481 0,15075394 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04686481 0,15054339 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04686481 0,15033343 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04686481 0,15012405 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04686481 0,14991525 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04686481 0,14970704 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04686481 0,1494994 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04686481 0,14929234 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04686481 0,14908585 ! glial cell migration GO:0008347 10 5 0,000 0,04686481 0,14887993 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04686481 0,14867457 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04686481 0,14846979 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04686481 0,14826557 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04686481 0,1480619 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04686481 0,1478588 ! neural plate development GO:0001840 6 5 0,000 0,04686481 0,14765625 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04686481 0,14745426 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04686481 0,14725282 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04686481 0,14705193 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04686481 0,14685159 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04686481 0,14665179 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04686481 0,14645254 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04686481 0,14625382 ! spindle assembly GO:0051225 5 5 0,000 0,04686481 0,14605565 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04686481 0,14585801 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04686481 0,1456609 ! organ regeneration GO:0031100 7 5 0,000 0,04686481 0,14546433 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04686481 0,14526828 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04686481 0,14507277 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04686481 0,14487778 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,04790044 0,14788055 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,04790044 0,14768232 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,04857701 0,14956778 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,05071078 0,15592887 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 2,000 0,05071078 0,15572069 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,05071078 0,15551306 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,05096174 0,15607456 ! gliogenesis GO:0042063 71 38 1,000 0,05096174 0,15586702 ! mesenchymal cell development GO:0014031 64 38 1,000 0,05096174 0,15566002 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,05096174 0,15545358 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,05338775 0,16263817 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,05338775 0,16242304 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,05338775 0,16220848 ! JNK cascade GO:0007254 54 39 1,000 0,05338775 0,16199448 ! developmental growth GO:0048589 62 39 1,000 0,05338775 0,16178105 ! synapse organization GO:0050808 55 39 1,000 0,05338775 0,16156818 ! regulation of T cell activation GO:0050863 128 89 2,000 0,05359968 0,1619964 ! hormone metabolic process GO:0042445 121 90 2,000 0,05507329 0,16623172 ! response to calcium ion GO:0051592 58 40 1,000 0,05585404 0,16836737 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,05585404 0,16814699 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,05585404 0,16792719 ! T cell differentiation GO:0030217 65 40 1,000 0,05585404 0,16770797 ! B cell differentiation GO:0030183 62 40 1,000 0,05585404 0,16748931 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,05585404 0,16727123 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,05585404 0,16705371 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,05585404 0,16683676 ! tRNA transcription GO:0009304 11 6 0,000 0,05597241 0,16697348 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05597241 0,16675719 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,05597241 0,16654147 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05597241 0,1663263 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05597241 0,16611168 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05597241 0,16589762 ! regulation of helicase activity GO:0051095 11 6 0,000 0,05597241 0,16568411 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05597241 0,16547115 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05597241 0,16525873 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05597241 0,16504686 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05597241 0,16483553 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05597241 0,16462475 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05597241 0,1644145 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05597241 0,16420479 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05597241 0,16399561 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,05597241 0,16378696 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05597241 0,16357885 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05597241 0,16337126 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05597241 0,1631642 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05597241 0,16295766 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05597241 0,16275165 ! neuron adhesion GO:0007158 9 6 0,000 0,05597241 0,16254615 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05597241 0,16234118 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05597241 0,16213672 ! signal peptide processing GO:0006465 8 6 0,000 0,05597241 0,16193277 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05597241 0,16172934 ! mRNA stabilization GO:0048255 15 6 0,000 0,05597241 0,16152642 GO:0043489|RNA stabilization, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05597241 0,161324 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05597241 0,16112209 ! opsonization GO:0008228 8 6 0,000 0,05597241 0,16092069 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05597241 0,16071979 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05597241 0,16051939 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05597241 0,16031949 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05597241 0,16012009 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,05597241 0,15992118 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05597241 0,15972277 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05597241 0,15952485 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05597241 0,15932742 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05597241 0,15913047 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05597241 0,15893402 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05597241 0,15873804 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05597241 0,15854255 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05597241 0,15834754 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05597241 0,15815301 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05597241 0,15795896 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05597241 0,15776538 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05597241 0,15757228 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05597241 0,15737965 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05597241 0,15718749 ! thymic T cell selection GO:0045061 12 6 0,000 0,05597241 0,1569958 ! protein lipoylation GO:0009249 10 6 0,000 0,05597241 0,15680457 ! drug transport GO:0015893 6 6 0,000 0,05597241 0,15661381 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05597241 0,15642351 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,05597241 0,15623368 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05597241 0,15604431 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05597241 0,15585539 ! histidine metabolic process GO:0006547 6 6 0,000 0,05597241 0,15566693 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05597241 0,15547893 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05597241 0,15529138 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05597241 0,15510428 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05597241 0,15491763 ! adenohypophysis development GO:0021984 10 6 0,000 0,05597241 0,15473143 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05597241 0,15454568 ! hyperosmotic response GO:0006972 8 6 0,000 0,05597241 0,15436038 ! microtubule nucleation GO:0007020 10 6 0,000 0,05597241 0,15417551 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05597241 0,15399109 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05597241 0,15380711 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05597241 0,15362357 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05597241 0,15344047 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05597241 0,1532578 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,05597241 0,15307557 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05597241 0,15289377 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05597241 0,1527124 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05597241 0,15253146 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05597241 0,15235095 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,05597241 0,15217087 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05597241 0,15199121 ! neuron apoptosis GO:0051402 8 6 0,000 0,05597241 0,15181197 ! organic alcohol transport GO:0015850 9 6 0,000 0,05597241 0,15163316 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,05597241 0,15145477 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05597241 0,1512768 ! carnitine transport GO:0015879 8 6 0,000 0,05597241 0,15109924 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05597241 0,1509221 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05597241 0,15074538 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05597241 0,15056907 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05597241 0,15039317 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05597241 0,15021768 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05597241 0,1500426 ! parturition GO:0007567 12 6 0,000 0,05597241 0,14986793 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05597241 0,14969367 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05597241 0,14951981 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05597241 0,14934635 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05597241 0,14917329 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05597241 0,14900064 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05597241 0,14882838 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05597241 0,14865653 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05597241 0,14848507 ! macrophage differentiation GO:0030225 10 6 0,000 0,05597241 0,148314 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05597241 0,14814333 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05597241 0,14797305 ! interaction with symbiont GO:0051702 8 6 0,000 0,05597241 0,14780316 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05597241 0,14763366 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05597241 0,14746455 ! eating behavior GO:0042755 6 6 0,000 0,05597241 0,14729583 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05597241 0,14712749 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05597241 0,14695954 ! response to copper ion GO:0046688 9 6 0,000 0,05597241 0,14679196 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05597241 0,14662478 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,05597241 0,14645797 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05597241 0,14629154 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05597241 0,14612549 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05597241 0,14595981 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05597241 0,14579451 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,05597241 0,14562958 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05597241 0,14546503 ! gas homeostasis GO:0033483 11 6 0,000 0,05597241 0,14530085 ! hair follicle maturation GO:0048820 7 6 0,000 0,05597241 0,14513704 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05597241 0,1449736 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05597241 0,14481052 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05597241 0,14464781 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05597241 0,14448547 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05597241 0,14432349 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05597241 0,14416187 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05597241 0,14400062 ! histone ubiquitination GO:0016574 7 6 0,000 0,05597241 0,14383972 ! regulation of meiosis GO:0040020 10 6 0,000 0,05597241 0,14367919 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05597241 0,14351901 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05597241 0,14335919 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05597241 0,14319972 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05597241 0,14304061 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05597241 0,14288186 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05597241 0,14272345 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05597241 0,1425654 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05597241 0,14240769 ! receptor internalization GO:0031623 9 6 0,000 0,05597241 0,14225033 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05597241 0,14209333 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05597241 0,14193666 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05597241 0,14178034 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05597241 0,14162437 ! protein deubiquitination GO:0016579 8 6 0,000 0,05597241 0,14146874 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05597241 0,14131345 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,05597241 0,1411585 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05597241 0,14100389 ! axonal fasciculation GO:0007413 9 6 0,000 0,05597241 0,14084962 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05597241 0,14069569 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05597241 0,14054209 ! midbrain development GO:0030901 6 6 0,000 0,05597241 0,14038883 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05597241 0,1402359 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05597241 0,1400833 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05597241 0,13993104 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05597241 0,1397791 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05597241 0,1396275 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05597241 0,13947622 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05597241 0,13932527 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05597241 0,13917465 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05597241 0,13902436 ! adult feeding behavior GO:0008343 6 6 0,000 0,05597241 0,13887438 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05597241 0,13872473 ! blastocyst growth GO:0001832 15 6 0,000 0,05597241 0,13857541 ! pigment granule transport GO:0051904 12 6 0,000 0,05597241 0,1384264 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05597241 0,13827772 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05597241 0,13812935 ! catecholamine transport GO:0051937 7 6 0,000 0,05597241 0,1379813 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05597241 0,13783357 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05597241 0,13768615 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05597241 0,13753905 ! protein prenylation GO:0018342 10 6 0,000 0,05597241 0,13739227 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05597241 0,13724579 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,05597241 0,13709963 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05597241 0,13695378 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05597241 0,13680824 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05597241 0,13666301 ! response to virus GO:0009615 122 91 2,000 0,05656618 0,1379663 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,05835965 0,14218983 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,05835965 0,14203937 ! glucose transport GO:0015758 52 41 1,000 0,05835965 0,14188922 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,05835965 0,14173939 ! biopolymer methylation GO:0043414 62 41 1,000 0,05835965 0,14158987 ! carbohydrate catabolic process GO:0016052 121 93 2,000 0,0596093 0,14446933 ! mitochondrial transport GO:0006839 60 42 1,000 0,0609036 0,14745083 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,0609036 0,14729578 ! hexose transport GO:0008645 54 42 1,000 0,0609036 0,14714106 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 1,000 0,0609036 0,14698666 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,0609036 0,14683259 ! regulation of cell shape GO:0008360 78 42 1,000 0,0609036 0,14667884 ! response to oxidative stress GO:0006979 141 94 2,000 0,06115926 0,14714049 ! positive regulation of binding GO:0051099 59 43 1,000 0,06348495 0,15257615 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,06348495 0,15241689 ! neuromuscular process GO:0050905 79 43 1,000 0,06348495 0,15225795 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,06348495 0,15209935 ! vesicle organization GO:0016050 79 43 1,000 0,06348495 0,15194108 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,06348495 0,15178314 ! methylation GO:0032259 64 43 1,000 0,06348495 0,15162552 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06499351 0,15506749 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06499351 0,1549068 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06499351 0,15474644 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06499351 0,15458642 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06499351 0,15442672 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06499351 0,15426735 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06499351 0,15410831 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06499351 0,1539496 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06499351 0,15379122 ! reproductive behavior GO:0019098 12 7 0,000 0,06499351 0,15363316 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06499351 0,15347543 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,06499351 0,15331802 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06499351 0,15316093 ! oligopeptide transport GO:0006857 11 7 0,000 0,06499351 0,15300416 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06499351 0,15284771 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06499351 0,15269159 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,06499351 0,15253578 ! pericardium development GO:0060039 8 7 0,000 0,06499351 0,15238029 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06499351 0,15222512 ! fibril organization GO:0043206 13 7 0,000 0,06499351 0,15207026 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,06499351 0,15191572 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06499351 0,15176149 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06499351 0,15160757 ! lipoprotein transport GO:0042953 9 7 0,000 0,06499351 0,15145397 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06499351 0,15130067 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06499351 0,15114769 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06499351 0,15099501 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06499351 0,15084265 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06499351 0,15069059 ! chemosensory behavior GO:0007635 9 7 0,000 0,06499351 0,15053884 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,06499351 0,15038739 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06499351 0,15023625 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06499351 0,15008541 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06499351 0,14993487 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06499351 0,14978463 ! reflex GO:0060004 12 7 0,000 0,06499351 0,1496347 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06499351 0,14948506 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06499351 0,14933573 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06499351 0,14918669 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06499351 0,14903795 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06499351 0,14888951 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06499351 0,14874136 ! spinal cord patterning GO:0021511 7 7 0,000 0,06499351 0,1485935 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,06499351 0,14844594 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06499351 0,14829868 ! adrenal gland development GO:0030325 17 7 0,000 0,06499351 0,1481517 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06499351 0,14800501 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06499351 0,14785862 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06499351 0,14771251 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06499351 0,1475667 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06499351 0,14742117 ! endosome organization GO:0007032 10 7 0,000 0,06499351 0,14727593 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06499351 0,14713097 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06499351 0,1469863 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06499351 0,14684191 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06499351 0,14669781 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06499351 0,14655399 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06499351 0,14641045 ! galactose metabolic process GO:0006012 10 7 0,000 0,06499351 0,14626719 ! vesicle fusion GO:0006906 15 7 0,000 0,06499351 0,14612421 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06499351 0,14598151 GO:0045851|pH reduction, ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06499351 0,14583909 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06499351 0,14569694 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06499351 0,14555508 ! retinol metabolic process GO:0042572 9 7 0,000 0,06499351 0,14541349 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06499351 0,14527217 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06499351 0,14513113 ! rRNA modification GO:0000154 12 7 0,000 0,06499351 0,14499036 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06499351 0,14484987 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,06499351 0,14470965 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06499351 0,1445697 ! intermediate filament organization GO:0045109 11 7 0,000 0,06499351 0,14443001 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06499351 0,1442906 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06499351 0,14415146 ! fibrinolysis GO:0042730 9 7 0,000 0,06499351 0,14401259 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06499351 0,14387398 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06499351 0,14373564 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06499351 0,14359756 ! response to tropane GO:0014073 13 7 0,000 0,06499351 0,14345976 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06499351 0,14332221 ! melanosome localization GO:0032400 10 7 0,000 0,06499351 0,14318493 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06499351 0,14304791 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06499351 0,14291115 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06499351 0,14277466 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06499351 0,14263842 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06499351 0,14250244 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06499351 0,14236673 ! mast cell activation GO:0045576 9 7 0,000 0,06499351 0,14223127 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06499351 0,14209607 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,06499351 0,14196113 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06499351 0,14182644 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06499351 0,141692 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,06499351 0,14155783 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06499351 0,1414239 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06499351 0,14129023 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06499351 0,14115681 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06499351 0,14102365 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06499351 0,14089073 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06499351 0,14075806 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06499351 0,14062565 ! response to tumor cell GO:0002347 12 7 0,000 0,06499351 0,14049348 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06499351 0,14036156 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06499351 0,14022989 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06499351 0,14009847 ! diuresis GO:0030146 12 7 0,000 0,06499351 0,13996729 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06499351 0,13983636 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06499351 0,13970567 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06499351 0,13957522 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06499351 0,13944502 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06499351 0,13931507 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06499351 0,13918535 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06499351 0,13905587 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06499351 0,13892664 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06499351 0,13879765 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06499351 0,13866889 ! lymph node development GO:0048535 9 7 0,000 0,06499351 0,13854038 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06499351 0,1384121 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06499351 0,13828406 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06499351 0,13815625 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06499351 0,13802868 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06499351 0,13790135 ! ATP catabolic process GO:0006200 10 7 0,000 0,06499351 0,13777425 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06499351 0,13764739 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06499351 0,13752076 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06499351 0,13739436 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06499351 0,1372682 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06499351 0,13714226 ! muscle adaptation GO:0043500 12 7 0,000 0,06499351 0,13701656 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06499351 0,13689108 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06499351 0,13676584 ! retina homeostasis GO:0001895 9 7 0,000 0,06499351 0,13664083 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06499351 0,13651604 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06499351 0,13639148 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06499351 0,13626715 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06499351 0,13614305 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06499351 0,13601917 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06499351 0,13589551 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06499351 0,13577208 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 0,06592115 0,13758499 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,06610275 0,13783891 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,06610275 0,13771405 ! cell maturation GO:0048469 60 45 1,000 0,06875608 0,1431122 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,07144404 0,14857259 ! regulation of ossification GO:0030278 71 46 1,000 0,07144404 0,14843838 ! histone modification GO:0016570 68 46 1,000 0,07144404 0,14830441 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0739289 0,15332415 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0739289 0,15318602 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0739289 0,15304814 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0739289 0,1529105 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0739289 0,15277312 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0739289 0,15263598 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0739289 0,15249909 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0739289 0,15236244 ! phosphate transport GO:0006817 10 8 0,000 0,0739289 0,15222603 ! N-glycan processing GO:0006491 12 8 0,000 0,0739289 0,15208988 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0739289 0,15195396 ! UTP metabolic process GO:0046051 8 8 0,000 0,0739289 0,15181829 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0739289 0,15168286 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0739289 0,15154767 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0739289 0,15141272 ! succinate metabolic process GO:0006105 14 8 0,000 0,0739289 0,15127801 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0739289 0,15114354 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0739289 0,15100931 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0739289 0,15087532 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0739289 0,15074156 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0739289 0,15060804 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0739289 0,15047476 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0739289 0,15034172 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,0739289 0,15020891 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0739289 0,15007633 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0739289 0,14994399 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0739289 0,14981188 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0739289 0,14968 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0739289 0,14954836 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0739289 0,14941694 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0739289 0,14928576 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0739289 0,14915481 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0739289 0,14902408 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0739289 0,14889359 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0739289 0,14876333 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0739289 0,14863329 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0739289 0,14850348 ! macrophage activation GO:0042116 12 8 0,000 0,0739289 0,14837389 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0739289 0,14824453 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0739289 0,1481154 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,0739289 0,14798649 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0739289 0,14785781 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0739289 0,14772935 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0739289 0,14760111 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0739289 0,1474731 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0739289 0,1473453 ! ruffle organization GO:0031529 11 8 0,000 0,0739289 0,14721773 ! osteoblast development GO:0002076 13 8 0,000 0,0739289 0,14709038 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0739289 0,14696325 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0739289 0,14683634 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0739289 0,14670965 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0739289 0,14658317 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,0739289 0,14645692 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0739289 0,14633088 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0739289 0,14620506 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0739289 0,14607945 ! brain morphogenesis GO:0048854 20 8 0,000 0,0739289 0,14595406 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0739289 0,14582889 ! segment specification GO:0007379 10 8 0,000 0,0739289 0,14570393 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0739289 0,14557918 ! cellular extravasation GO:0045123 11 8 0,000 0,0739289 0,14545465 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0739289 0,14533033 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0739289 0,14520622 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0739289 0,14508232 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0739289 0,14495864 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0739289 0,14483516 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0739289 0,1447119 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0739289 0,14458884 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0739289 0,144466 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0739289 0,14434336 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0739289 0,14422093 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0739289 0,14409871 ! icosanoid secretion GO:0032309 12 8 0,000 0,0739289 0,1439767 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0739289 0,14385489 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0739289 0,14373329 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0739289 0,14361189 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0739289 0,1434907 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0739289 0,14336971 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0739289 0,14324893 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0739289 0,14312835 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0739289 0,14300797 ! sterol catabolic process GO:0016127 9 8 0,000 0,0739289 0,1428878 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0739289 0,14276783 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0739289 0,14264805 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0739289 0,14252848 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0739289 0,14240911 ! prophase GO:0051324 11 8 0,000 0,0739289 0,14228994 ! S phase GO:0051320 8 8 0,000 0,0739289 0,14217097 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0739289 0,1420522 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0739289 0,14193362 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0739289 0,14181525 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0739289 0,14169707 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0739289 0,14157908 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0739289 0,1414613 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,0739289 0,14134371 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0739289 0,14122631 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0739289 0,14110911 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0739289 0,14099211 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0739289 0,14087529 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0739289 0,14075868 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0739289 0,14064225 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0739289 0,14052602 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0739289 0,14040998 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0739289 0,14029413 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0739289 0,14017847 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0739289 0,140063 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,0739289 0,13994772 ! viral infectious cycle GO:0019058 71 47 1,000 0,07416572 0,14028056 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,07416572 0,14016529 ! endocrine system development GO:0035270 83 47 1,000 0,07416572 0,14005022 ! covalent chromatin modification GO:0016569 75 47 1,000 0,07416572 0,13993533 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,07416572 0,13982062 ! response to temperature stimulus GO:0009266 62 48 1,000 0,07692026 0,14489484 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,07692026 0,14477627 ! heart morphogenesis GO:0003007 65 48 1,000 0,07692026 0,14465789 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,07970678 0,14977581 ! germ cell development GO:0007281 68 49 1,000 0,07970678 0,14965355 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,07970678 0,14953148 ! maintenance of location GO:0051235 84 49 1,000 0,07970678 0,14940961 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,08252443 0,1545653 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,08252443 0,15443953 ! lipid modification GO:0030258 73 50 1,000 0,08252443 0,15431397 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,08277942 0,15466504 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,08277942 0,1545395 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,08277942 0,15441416 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,08277942 0,15428903 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,08277942 0,1541641 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,08277942 0,15403937 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,08277942 0,15391484 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,08277942 0,15379052 ! GTP metabolic process GO:0046039 9 9 0,000 0,08277942 0,15366639 ! elastic fiber assembly GO:0048251 13 9 0,000 0,08277942 0,15354247 ! social behavior GO:0035176 14 9 0,000 0,08277942 0,15341874 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,08277942 0,15329522 ! artery development GO:0060840 19 9 0,000 0,08277942 0,15317189 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,08277942 0,15304876 ! response to pain GO:0048265 16 9 0,000 0,08277942 0,15292583 ! protein complex disassembly GO:0043241 17 9 0,000 0,08277942 0,1528031 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,08277942 0,15268056 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,08277942 0,15255822 ! lung alveolus development GO:0048286 17 9 0,000 0,08277942 0,15243608 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,08277942 0,15231413 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,08277942 0,15219238 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,08277942 0,15207082 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,08277942 0,15194945 ! ventral spinal cord development GO:0021517 11 9 0,000 0,08277942 0,15182828 ! protein targeting to ER GO:0045047 19 9 0,000 0,08277942 0,1517073 ! endoderm development GO:0007492 12 9 0,000 0,08277942 0,15158651 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,08277942 0,15146592 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,08277942 0,15134552 ! arginine catabolic process GO:0006527 10 9 0,000 0,08277942 0,15122531 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,08277942 0,15110529 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,08277942 0,15098546 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,08277942 0,15086582 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,08277942 0,15074637 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,08277942 0,15062711 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,08277942 0,15050803 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,08277942 0,15038915 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,08277942 0,15027045 ! mannose metabolic process GO:0006013 9 9 0,000 0,08277942 0,15015194 ! receptor clustering GO:0043113 15 9 0,000 0,08277942 0,15003362 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,08277942 0,14991548 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,08277942 0,14979753 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,08277942 0,14967977 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,08277942 0,14956219 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,08277942 0,14944479 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,08277942 0,14932758 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,08277942 0,14921055 ! blastoderm segmentation GO:0007350 11 9 0,000 0,08277942 0,14909371 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,08277942 0,14897704 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,08277942 0,14886056 ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,08277942 0,14874427 ! erythrocyte development GO:0048821 11 9 0,000 0,08277942 0,14862815 ! renal water homeostasis GO:0003091 14 9 0,000 0,08277942 0,14851222 ! postreplication repair GO:0006301 11 9 0,000 0,08277942 0,14839646 ! mRNA cleavage GO:0006379 13 9 0,000 0,08277942 0,14828089 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,08277942 0,1481655 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,08277942 0,14805028 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,08277942 0,14793525 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,08277942 0,14782039 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,08277942 0,14770571 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,08277942 0,14759121 ! acid secretion GO:0046717 14 9 0,000 0,08277942 0,14747689 ! musculoskeletal movement GO:0050881 11 9 0,000 0,08277942 0,14736274 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,08277942 0,14724877 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,08277942 0,14713498 ! purine base metabolic process GO:0006144 18 9 0,000 0,08277942 0,14702136 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,08277942 0,14690792 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,08277942 0,14679465 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,08277942 0,14668156 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,08277942 0,14656864 ! detection of calcium ion GO:0005513 13 9 0,000 0,08277942 0,14645589 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,08277942 0,14634332 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,08277942 0,14623092 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,08277942 0,1461187 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,08277942 0,14600664 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,08277942 0,14589476 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,08277942 0,14578305 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,08277942 0,14567151 ! prepulse inhibition GO:0060134 14 9 0,000 0,08277942 0,14556014 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,08277942 0,14544894 ! insulin secretion GO:0030073 17 9 0,000 0,08277942 0,14533791 ! sequestering of metal ion GO:0051238 11 9 0,000 0,08277942 0,14522705 ! establishment of cell polarity GO:0030010 12 9 0,000 0,08277942 0,14511636 ! nucleus localization GO:0051647 15 9 0,000 0,08277942 0,14500584 ! regulation of synapse organization GO:0050807 12 9 0,000 0,08277942 0,14489548 ! muscle fiber development GO:0048747 74 51 1,000 0,08537237 0,14932049 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,08537237 0,14920703 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,09115581 0,1591939 ! kidney development GO:0001822 90 53 1,000 0,09115581 0,15907312 ! cell projection assembly GO:0030031 76 53 1,000 0,09115581 0,15895252 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,09154585 0,15951171 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,09154585 0,15939095 ! neuron fate specification GO:0048665 11 10 0,000 0,09154585 0,15927039 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,09154585 0,15915 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,09154585 0,1590298 ! thyroid gland development GO:0030878 19 10 0,000 0,09154585 0,15890977 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,09154585 0,15878993 ! synapsis GO:0007129 13 10 0,000 0,09154585 0,15867027 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,09154585 0,15855079 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,09154585 0,15843149 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,09154585 0,15831237 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,09154585 0,15819343 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,09154585 0,15807466 ! androgen metabolic process GO:0008209 13 10 0,000 0,09154585 0,15795608 ! phospholipid efflux GO:0033700 16 10 0,000 0,09154585 0,15783767 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,09154585 0,15771944 ! blood vessel remodeling GO:0001974 21 10 0,000 0,09154585 0,15760139 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,09154585 0,15748351 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,09154585 0,15736581 ! pathogenesis GO:0009405 13 10 0,000 0,09154585 0,15724828 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,09154585 0,15713093 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,09154585 0,15701376 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,09154585 0,15689676 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,09154585 0,15677993 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,09154585 0,15666328 ! melanocyte differentiation GO:0030318 15 10 0,000 0,09154585 0,1565468 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,09154585 0,1564305 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,09154585 0,15631437 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,09154585 0,15619841 ! response to X-ray GO:0010165 16 10 0,000 0,09154585 0,15608262 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,09154585 0,155967 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,09154585 0,15585156 ! lipid digestion GO:0044241 15 10 0,000 0,09154585 0,15573628 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,09154585 0,15562118 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,09154585 0,15550624 ! UV protection GO:0009650 14 10 0,000 0,09154585 0,15539148 ! entry into host cell GO:0030260 20 10 0,000 0,09154585 0,15527688 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,09154585 0,15516246 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,09154585 0,1550482 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,09154585 0,15493411 ! regulation of bone resorption GO:0045124 24 10 0,000 0,09154585 0,15482018 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,09154585 0,15470643 ! regulation of organ growth GO:0046620 11 10 0,000 0,09154585 0,15459284 ! response to dsRNA GO:0043331 18 10 0,000 0,09154585 0,15447942 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,09154585 0,15436617 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,09154585 0,15425308 ! embryonic axis specification GO:0000578 12 10 0,000 0,09154585 0,15414015 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,09154585 0,1540274 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,09154585 0,1539148 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,09154585 0,15380238 ! fucose catabolic process GO:0019317 16 10 0,000 0,09154585 0,15369011 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,09154585 0,15357801 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,09154585 0,15346607 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,09154585 0,1533543 ! zymogen activation GO:0031638 14 10 0,000 0,09154585 0,15324269 ! salivary gland development GO:0007431 22 10 0,000 0,09154585 0,15313124 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,09154585 0,15301995 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,09154585 0,15290882 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,09154585 0,15279786 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,09154585 0,15268706 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,09154585 0,15257641 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,09154585 0,15246593 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,09154585 0,15235561 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,09154585 0,15224545 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,09154585 0,15213544 ! detection of bacterium GO:0016045 10 10 0,000 0,09154585 0,1520256 ! embryonic gut development GO:0048566 11 10 0,000 0,09154585 0,15191591 ! activation of innate immune response GO:0002218 10 10 0,000 0,09154585 0,15180638 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,09154585 0,15169701 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,09154585 0,1515878 ! developmental induction GO:0031128 13 10 0,000 0,09154585 0,15147874 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,09154585 0,15136984 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,09154585 0,1512611 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,09154585 0,15115251 ! amino acid transport GO:0006865 84 54 1,000 0,0940897 0,15524126 ! detection of external stimulus GO:0009581 66 54 1,000 0,0940897 0,15512998 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,0940897 0,15501885 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,10003788 0,16470087 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,10003788 0,16458306 ! rRNA transcription GO:0009303 17 11 0,000 0,10022899 0,16477961 ! respiratory burst GO:0045730 14 11 0,000 0,10022899 0,16466191 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,10022899 0,16454438 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,10022899 0,16442702 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,10022899 0,16430982 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,10022899 0,16419279 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,10022899 0,16407593 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,10022899 0,16395923 ! RNA polyadenylation GO:0043631 19 11 0,000 0,10022899 0,1638427 ! mating GO:0007618 14 11 0,000 0,10022899 0,16372633 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,10022899 0,16361013 ! T cell proliferation GO:0042098 20 11 0,000 0,10022899 0,1634941 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,10022899 0,16337823 ! bone resorption GO:0045453 16 11 0,000 0,10022899 0,16326252 ! regulated secretory pathway GO:0045055 14 11 0,000 0,10022899 0,16314698 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,10022899 0,1630316 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,10022899 0,16291638 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,10022899 0,16280133 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,10022899 0,16268643 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,10022899 0,1625717 ! syncytium formation GO:0006949 15 11 0,000 0,10022899 0,16245714 ! plasma membrane organization GO:0007009 18 11 0,000 0,10022899 0,16234273 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,10022899 0,16222848 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,10022899 0,1621144 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,10022899 0,16200048 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,10022899 0,16188671 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,10022899 0,16177311 ! adult heart development GO:0007512 11 11 0,000 0,10022899 0,16165966 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,10022899 0,16154637 ! temperature homeostasis GO:0001659 16 11 0,000 0,10022899 0,16143325 ! L-glutamate transport GO:0015813 16 11 0,000 0,10022899 0,16132028 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,10022899 0,16120747 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,10022899 0,16109481 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,10022899 0,16098232 ! stem cell development GO:0048864 29 11 0,000 0,10022899 0,16086998 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,10022899 0,16075779 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,10022899 0,16064577 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,10022899 0,1605339 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,10022899 0,16042218 ! vasoconstriction GO:0042310 15 11 0,000 0,10022899 0,16031062 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,10022899 0,16019922 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,10022899 0,16008797 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,10022899 0,15997687 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,10022899 0,15986593 ! ribosome assembly GO:0042255 13 11 0,000 0,10022899 0,15975515 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,10022899 0,15964451 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,10022899 0,15953403 ! chromatin silencing GO:0006342 19 11 0,000 0,10022899 0,1594237 ! nucleosome positioning GO:0016584 13 11 0,000 0,10022899 0,15931353 ! regulation of isotype switching GO:0045191 19 11 0,000 0,10022899 0,15920351 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,10022899 0,15909363 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,10022899 0,15898391 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,10022899 0,15887435 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,10022899 0,15876493 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,10022899 0,15865566 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,10022899 0,15854654 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,10022899 0,15843758 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,10022899 0,15832876 ! cholesterol efflux GO:0033344 19 11 0,000 0,10022899 0,15822009 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,10022899 0,15811157 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,10022899 0,15800321 ! germ cell migration GO:0008354 18 11 0,000 0,10022899 0,15789498 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,10022899 0,15778691 ! defense response to fungus GO:0050832 12 11 0,000 0,10022899 0,15767899 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,10022899 0,15757121 ! lysogeny GO:0030069 18 11 0,000 0,10022899 0,15746358 GO:0019047|provirus integration, ! acrosome reaction GO:0007340 13 11 0,000 0,10022899 0,15735609 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,10022899 0,15724876 ! carbohydrate transport GO:0008643 74 57 1,000 0,10305062 0,16156538 ! secondary metabolic process GO:0019748 84 57 1,000 0,10305062 0,16145533 ! developmental maturation GO:0021700 75 57 1,000 0,10305062 0,16134542 ! gonad development GO:0008406 79 57 1,000 0,10305062 0,16123566 ! lactation GO:0007595 20 12 0,000 0,10882963 0,17016189 ! reproductive cellular process GO:0048610 14 12 0,000 0,10882963 0,17004629 ! tRNA modification GO:0006400 14 12 0,000 0,10882963 0,16993085 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,10882963 0,16981557 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,10882963 0,16970044 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,10882963 0,16958546 ! non-recombinational repair GO:0000726 19 12 0,000 0,10882963 0,16947065 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,10882963 0,16935598 ! peroxisomal transport GO:0043574 21 12 0,000 0,10882963 0,16924148 ! cartilage condensation GO:0001502 18 12 0,000 0,10882963 0,16912713 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,10882963 0,16901293 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,10882963 0,16889888 ! heart looping GO:0001947 15 12 0,000 0,10882963 0,16878499 ! palate development GO:0060021 15 12 0,000 0,10882963 0,16867126 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,10882963 0,16855767 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,10882963 0,16844424 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,10882963 0,16833097 ! arginine metabolic process GO:0006525 13 12 0,000 0,10882963 0,16821784 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,10882963 0,16810487 ! methionine metabolic process GO:0006555 13 12 0,000 0,10882963 0,16799204 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,10882963 0,16787937 ! Golgi organization GO:0007030 18 12 0,000 0,10882963 0,16776685 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,10882963 0,16765448 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,10882963 0,16754227 ! monoamine transport GO:0015844 13 12 0,000 0,10882963 0,1674302 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,10882963 0,16731828 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,10882963 0,16720651 ! L-amino acid transport GO:0015807 20 12 0,000 0,10882963 0,16709489 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,10882963 0,16698342 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,10882963 0,1668721 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,10882963 0,16676092 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,10882963 0,1666499 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,10882963 0,16653902 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,10882963 0,16642829 ! cerebellum development GO:0021549 13 12 0,000 0,10882963 0,1663177 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,10882963 0,16620727 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,10882963 0,16609698 ! histone methylation GO:0016571 15 12 0,000 0,10882963 0,16598683 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,10882963 0,16587684 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,10882963 0,16576698 ! regulation of epidermis development GO:0045682 17 12 0,000 0,10882963 0,16565728 ! intestinal absorption GO:0050892 19 12 0,000 0,10882963 0,16554772 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,10882963 0,1654383 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,10882963 0,16532903 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,10882963 0,1652199 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,10882963 0,16511091 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,10882963 0,16500207 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,10882963 0,16489338 ! microspike assembly GO:0030035 23 12 0,000 0,10882963 0,16478482 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,10882963 0,16467641 ! response to cold GO:0009409 14 12 0,000 0,10882963 0,16456814 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,10914964 0,16494361 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,11223445 0,16949392 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,11534184 0,17407233 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,11534184 0,17395818 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,11534184 0,17384419 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11734854 0,17675288 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11734854 0,17663721 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,11734854 0,17652168 ! water transport GO:0006833 17 13 0,000 0,11734854 0,17640631 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11734854 0,17629108 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11734854 0,17617601 ! lipid localization GO:0010876 24 13 0,000 0,11734854 0,17606109 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11734854 0,17594632 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11734854 0,17583169 ! organelle fusion GO:0048284 28 13 0,000 0,11734854 0,17571722 ! endocrine pancreas development GO:0031018 19 13 0,000 0,11734854 0,1756029 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,11734854 0,17548872 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11734854 0,17537469 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11734854 0,17526081 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,11734854 0,17514708 ! glutamate metabolic process GO:0006536 18 13 0,000 0,11734854 0,1750335 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11734854 0,17492006 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,11734854 0,17480677 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,11734854 0,17469363 ! NAD metabolic process GO:0019674 21 13 0,000 0,11734854 0,17458063 ! exocrine system development GO:0035272 27 13 0,000 0,11734854 0,17446778 ! bone mineralization GO:0030282 15 13 0,000 0,11734854 0,17435507 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11734854 0,17424251 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11734854 0,1741301 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11734854 0,17401783 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11734854 0,1739057 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11734854 0,17379372 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,11734854 0,17368189 ! regulation of cellular pH GO:0030641 20 13 0,000 0,11734854 0,17357019 ! tissue regeneration GO:0042246 21 13 0,000 0,11734854 0,17345864 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11734854 0,17334724 ! cofactor transport GO:0051181 19 13 0,000 0,11734854 0,17323598 ! NADP metabolic process GO:0006739 18 13 0,000 0,11734854 0,17312486 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11734854 0,17301388 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11734854 0,17290304 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11734854 0,17279235 ! gas transport GO:0015669 18 13 0,000 0,11734854 0,1726818 ! regulation of RNA stability GO:0043487 28 13 0,000 0,11734854 0,17257139 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11734854 0,17246112 ! regulation of axon extension GO:0030516 23 13 0,000 0,11734854 0,17235099 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11734854 0,172241 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11734854 0,17213115 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11734854 0,17202145 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11734854 0,17191188 ! cellular hormone metabolic process GO:0034754 87 62 1,000 0,1184711 0,17344591 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,1184711 0,17333557 ! superoxide anion generation GO:0042554 18 14 0,000 0,12578651 0,18392179 ! neuron maturation GO:0042551 21 14 0,000 0,12578651 0,18380494 ! regulation of S phase GO:0033261 18 14 0,000 0,12578651 0,18368823 ! myotube differentiation GO:0014902 21 14 0,000 0,12578651 0,18357168 ! inositol metabolic process GO:0006020 20 14 0,000 0,12578651 0,18345527 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,12578651 0,18333902 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,12578651 0,18322291 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,12578651 0,18310694 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,12578651 0,18299112 ! gene silencing by RNA GO:0031047 20 14 0,000 0,12578651 0,18287545 ! response to cAMP GO:0051591 19 14 0,000 0,12578651 0,18275993 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,12578651 0,18264455 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,12578651 0,18252932 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,12578651 0,18241423 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,12578651 0,18229929 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,12578651 0,18218449 ! glycine metabolic process GO:0006544 22 14 0,000 0,12578651 0,18206984 ! cellular response to starvation GO:0009267 21 14 0,000 0,12578651 0,18195533 ! lysosomal transport GO:0007041 20 14 0,000 0,12578651 0,18184096 ! regulation of heart rate GO:0002027 23 14 0,000 0,12578651 0,18172674 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,12578651 0,18161266 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,12578651 0,18149873 ! embryo implantation GO:0007566 27 14 0,000 0,12578651 0,18138493 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,12578651 0,18127128 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,12578651 0,18115778 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,12578651 0,18104441 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,12578651 0,18093119 ! axon cargo transport GO:0008088 27 14 0,000 0,12578651 0,1808181 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,12578651 0,18070516 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,12578651 0,18059236 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,12578651 0,18047971 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,12578651 0,18036719 ! mRNA splice site selection GO:0006376 26 14 0,000 0,12578651 0,18025481 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,12578651 0,18014257 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,12578651 0,18003047 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,12578651 0,17991851 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,12578651 0,17980669 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,12578651 0,17969501 ! muscle maintenance GO:0046716 19 14 0,000 0,12578651 0,17958347 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,12578651 0,17947206 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,12578651 0,1793608 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,12578651 0,17924967 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,12578651 0,17913868 ! cell killing GO:0001906 20 14 0,000 0,12578651 0,17902783 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,12578651 0,17891711 ! cilium assembly GO:0042384 20 14 0,000 0,12578651 0,17880653 ! peptide hormone secretion GO:0030072 23 14 0,000 0,12578651 0,17869609 ! B cell activation GO:0042113 104 65 1,000 0,12798318 0,18170451 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,12798318 0,18159242 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,12798318 0,18148046 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,13414429 0,19009973 ! positive regulation of cell size GO:0045793 20 15 0,000 0,13414429 0,18998267 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,13414429 0,18986576 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,13414429 0,18974899 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,13414429 0,18963236 ! skin development GO:0043588 25 15 0,000 0,13414429 0,18951588 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,13414429 0,18939954 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,13414429 0,18928335 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,13414429 0,18916729 ! bile acid metabolic process GO:0008206 22 15 0,000 0,13414429 0,18905138 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,13414429 0,18893561 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,13414429 0,18881999 ! adult walking behavior GO:0007628 25 15 0,000 0,13414429 0,1887045 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,13414429 0,18858915 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,13414429 0,18847395 ! myoblast differentiation GO:0045445 27 15 0,000 0,13414429 0,18835889 ! centrosome cycle GO:0007098 16 15 0,000 0,13414429 0,18824396 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,13414429 0,18812918 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,13414429 0,18801454 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,13414429 0,18790003 ! response to osmotic stress GO:0006970 22 15 0,000 0,13414429 0,18778567 ! vesicle coating GO:0006901 25 15 0,000 0,13414429 0,18767145 ! DNA integration GO:0015074 22 15 0,000 0,13414429 0,18755736 ! peptide secretion GO:0002790 27 15 0,000 0,13414429 0,18744341 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,13414429 0,1873296 ! regulation of vasodilation GO:0042312 24 15 0,000 0,13414429 0,18721593 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,13414429 0,1871024 ! neuron recognition GO:0008038 22 15 0,000 0,13414429 0,186989 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,13414429 0,18687575 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,13414429 0,18676262 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,13414429 0,18664964 ! biomineral formation GO:0031214 18 15 0,000 0,13414429 0,18653679 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,13414429 0,18642408 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,13414429 0,18631151 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,13414429 0,18619907 ! organic cation transport GO:0015695 19 15 0,000 0,13414429 0,18608676 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,13414429 0,1859746 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,13414429 0,18586256 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,13414429 0,18575067 ! peptide hormone processing GO:0016486 19 15 0,000 0,13414429 0,1856389 ! rhythmic process GO:0048511 105 68 1,000 0,13766773 0,19040034 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,14093122 0,19479676 ! protein secretion GO:0009306 27 16 0,000 0,14242263 0,19673997 ! hormone secretion GO:0046879 25 16 0,000 0,14242263 0,19662188 ! bone remodeling GO:0046849 24 16 0,000 0,14242263 0,19650393 ! endothelial cell migration GO:0043542 22 16 0,000 0,14242263 0,19638612 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,14242263 0,19626846 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,14242263 0,19615093 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,14242263 0,19603355 ! patterning of blood vessels GO:0001569 24 16 0,000 0,14242263 0,1959163 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,14242263 0,1957992 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,14242263 0,19568223 ! protein polyubiquitination GO:0000209 26 16 0,000 0,14242263 0,19556541 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,14242263 0,19544872 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,14242263 0,19533217 ! fructose metabolic process GO:0006000 20 16 0,000 0,14242263 0,19521577 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,14242263 0,1950995 ! protein export from nucleus GO:0006611 24 16 0,000 0,14242263 0,19498337 ! negative regulation of immune response GO:0050777 28 16 0,000 0,14242263 0,19486737 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,14242263 0,19475152 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,14242263 0,1946358 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,14242263 0,19452022 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,14242263 0,19440478 ! neural crest cell migration GO:0001755 24 16 0,000 0,14242263 0,19428948 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,14242263 0,19417431 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,14242263 0,19405927 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,14242263 0,19394438 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,14242263 0,19382962 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,14242263 0,19371499 ! sperm-egg recognition GO:0035036 16 16 0,000 0,14242263 0,19360051 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,14242263 0,19348615 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,14242263 0,19337193 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,14242263 0,19325785 ! negative regulation of translation GO:0017148 22 16 0,000 0,14242263 0,1931439 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,14421133 0,19545436 ! humoral immune response GO:0006959 86 70 1,000 0,14421133 0,19533926 ! amine transport GO:0015837 101 70 1,000 0,14421133 0,19522428 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,14750744 0,19956889 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,1506223 0,20366331 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,1506223 0,20354365 ! negative regulation of defense response GO:0031348 19 17 0,000 0,1506223 0,20342413 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,1506223 0,20330475 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,1506223 0,20318551 ! glycerol metabolic process GO:0006071 20 17 0,000 0,1506223 0,20306641 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,1506223 0,20294745 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,1506223 0,20282863 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,1506223 0,20270994 ! signal complex assembly GO:0007172 29 17 0,000 0,1506223 0,2025914 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,1506223 0,202473 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,1506223 0,20235473 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,1506223 0,2022366 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,1506223 0,20211861 ! keratinization GO:0031424 17 17 0,000 0,1506223 0,20200076 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,1506223 0,20188304 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,1506223 0,20176546 ! retinoid metabolic process GO:0001523 22 17 0,000 0,1506223 0,20164802 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,1506223 0,20153071 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,1506223 0,20141354 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,1506223 0,20129651 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,1506223 0,20117961 ! membrane budding GO:0006900 29 17 0,000 0,1506223 0,20106285 ! heme metabolic process GO:0042168 27 17 0,000 0,1506223 0,20094623 ! body fluid secretion GO:0007589 27 17 0,000 0,1506223 0,20082974 ! stem cell differentiation GO:0048863 36 17 0,000 0,1506223 0,20071338 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,1506223 0,20059716 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,1506223 0,20048107 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,1506223 0,20036512 ! sensory perception of pain GO:0019233 23 17 0,000 0,1506223 0,2002493 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,1506223 0,20013362 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,1506223 0,20001807 ! synaptogenesis GO:0007416 24 17 0,000 0,1506223 0,19990265 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,1506223 0,19978737 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,1506223 0,19967222 ! cell-cell junction organization GO:0045216 25 17 0,000 0,1506223 0,1995572 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,1506223 0,19944231 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,1506223 0,19932756 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,1506223 0,19921294 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,1506223 0,19909845 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,15081896 0,19924388 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,15414529 0,20352134 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,15414529 0,20340457 ! protein import into nucleus GO:0006606 118 74 1,000 0,15748586 0,2076935 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,15748586 0,20757448 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,15874404 0,20911299 ! positive regulation of translation GO:0045727 28 18 0,000 0,15874404 0,20899329 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,15874404 0,20887373 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,15874404 0,20875431 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,15874404 0,20863502 ! cAMP metabolic process GO:0046058 33 18 0,000 0,15874404 0,20851587 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,15874404 0,20839685 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,15874404 0,20827797 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,15874404 0,20815923 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,15874404 0,20804062 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,15874404 0,20792214 ! pancreas development GO:0031016 26 18 0,000 0,15874404 0,2078038 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,15874404 0,2076856 ! glutamine metabolic process GO:0006541 23 18 0,000 0,15874404 0,20756753 ! response to retinoic acid GO:0032526 25 18 0,000 0,15874404 0,20744959 ! central nervous system neuron development GO:0021954 30 18 0,000 0,15874404 0,20733179 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,15874404 0,20721412 ! fucose metabolic process GO:0006004 26 18 0,000 0,15874404 0,20709659 ! response to fungus GO:0009620 19 18 0,000 0,15874404 0,20697918 ! peptide cross-linking GO:0018149 31 18 0,000 0,15874404 0,20686192 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,15874404 0,20674478 ! heart process GO:0003015 27 18 0,000 0,15874404 0,20662778 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,15874404 0,20651091 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,15874404 0,20639417 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,15874404 0,20627756 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,15874404 0,20616109 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,15874404 0,20604474 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,15874404 0,20592853 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,15874404 0,20581245 ! vitamin transport GO:0051180 24 18 0,000 0,15874404 0,2056965 ! hormone transport GO:0009914 27 18 0,000 0,15874404 0,20558068 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,15874404 0,20546499 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,15874404 0,20534943 ! cell-cell recognition GO:0009988 20 18 0,000 0,15874404 0,205234 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,15874404 0,2051187 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,15874404 0,20500353 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,15874404 0,20488849 ! response to nutrient GO:0007584 104 75 1,000 0,16084009 0,2074774 ! nuclear import GO:0051170 121 75 1,000 0,16084009 0,2073611 ! amine biosynthetic process GO:0009309 97 76 1,000 0,16420742 0,21158379 ! response to unfolded protein GO:0006986 99 76 1,000 0,16420742 0,21146532 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,16678857 0,21466912 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,16678857 0,21454906 ! positive regulation of ossification GO:0045778 30 19 0,000 0,16678857 0,21442913 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,16678857 0,21430934 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,16678857 0,21418968 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,16678857 0,21407015 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,16678857 0,21395076 ! sensory perception of taste GO:0050909 23 19 0,000 0,16678857 0,2138315 ! smooth muscle contraction GO:0006939 36 19 0,000 0,16678857 0,21371237 ! peroxisome organization GO:0007031 29 19 0,000 0,16678857 0,21359338 ! digestive system process GO:0022600 30 19 0,000 0,16678857 0,21347452 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,16678857 0,21335579 ! response to vitamin A GO:0033189 26 19 0,000 0,16678857 0,21323719 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,16678857 0,21311873 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,16678857 0,21300039 ! response to starvation GO:0042594 30 19 0,000 0,16678857 0,21288219 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,16678857 0,21276412 ! plasma membrane fusion GO:0045026 23 19 0,000 0,16678857 0,21264618 ! cytolysis GO:0019835 20 19 0,000 0,16678857 0,21252837 ! vasodilation GO:0042311 33 19 0,000 0,16678857 0,21241069 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,16678857 0,21229314 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,16678857 0,21217572 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,16678857 0,21205844 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,16678857 0,21194128 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,16678857 0,21182425 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,16678857 0,21170735 ! sarcomere organization GO:0045214 23 19 0,000 0,16678857 0,21159057 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,16678857 0,21147393 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,16678857 0,21135742 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,16678857 0,21124103 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,16678857 0,21112477 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,16678857 0,21100864 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,16678857 0,21089264 ! protein stabilization GO:0050821 26 19 0,000 0,16678857 0,21077676 ! protein ubiquitination GO:0016567 125 77 1,000 0,1675873 0,21166985 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,1675873 0,21155368 ! T cell activation GO:0042110 134 79 1,000 0,17438257 0,22001092 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,17475663 0,22036198 ! iron ion transport GO:0006826 37 20 0,000 0,17475663 0,22024124 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,17475663 0,22012062 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,17475663 0,22000014 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,17475663 0,21987979 ! response to vitamin GO:0033273 29 20 0,000 0,17475663 0,21975957 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,17475663 0,21963949 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,17475663 0,21951953 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,17475663 0,2193997 ! spinal cord development GO:0021510 31 20 0,000 0,17475663 0,21928001 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,17475663 0,21916045 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,17475663 0,21904101 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,17475663 0,21892171 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,17475663 0,21880254 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,17475663 0,21868349 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,17475663 0,21856458 ! collagen fibril organization GO:0030199 45 20 0,000 0,17475663 0,21844579 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,17475663 0,21832714 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,17475663 0,21820861 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,17475663 0,21809021 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,17475663 0,21797194 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,17475663 0,2178538 ! alditol metabolic process GO:0019400 24 20 0,000 0,17475663 0,21773578 ! actin filament-based movement GO:0030048 34 20 0,000 0,17475663 0,2176179 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,17779689 0,22128401 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,17779689 0,22116433 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,18122165 0,22530259 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,18264895 0,2269544 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,18264895 0,22683185 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,18264895 0,22670944 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,18264895 0,22658716 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,18264895 0,22646501 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,18264895 0,22634299 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,18264895 0,2262211 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,18264895 0,22609935 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,18264895 0,22597772 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,18264895 0,22585623 ! vesicle docking GO:0048278 27 21 0,000 0,18264895 0,22573487 ! phototransduction GO:0007602 25 21 0,000 0,18264895 0,22561363 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,18264895 0,22549253 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,18264895 0,22537156 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,18264895 0,22525072 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,18264895 0,22513 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,18264895 0,22500942 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,18264895 0,22488897 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,18264895 0,22476864 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,18264895 0,22464844 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,18264895 0,22452837 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,18264895 0,22440843 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,18264895 0,22428862 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,18264895 0,22416894 ! fatty acid transport GO:0015908 30 21 0,000 0,18264895 0,22404938 ! immunoglobulin production GO:0002377 33 21 0,000 0,18264895 0,22392995 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,18264895 0,22381065 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,18264895 0,22369147 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,18264895 0,22357243 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,18264895 0,2234535 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,18264895 0,22333471 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,18264895 0,22321604 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,18264895 0,2230975 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,18264895 0,22297908 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,18264895 0,22286079 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,18264895 0,22274262 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,18264895 0,22262458 ! detection of stimulus GO:0051606 108 82 1,000 0,18465634 0,2249521 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,18810045 0,22902649 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,19046624 0,23178431 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,19046624 0,23166174 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,19046624 0,23153929 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,19046624 0,23141698 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,19046624 0,2312948 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,19046624 0,23117274 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,19046624 0,23105082 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,19046624 0,23092902 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,19046624 0,23080735 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,19046624 0,23068581 ! lysosome organization GO:0007040 37 22 0,000 0,19046624 0,23056439 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,19046624 0,23044311 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,19046624 0,23032195 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,19046624 0,23020092 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,19046624 0,23008001 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,19046624 0,22995924 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,19046624 0,22983859 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,19046624 0,22971806 ! neural tube closure GO:0001843 33 22 0,000 0,19046624 0,22959767 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! rRNA metabolic process GO:0016072 107 85 1,000 0,19501503 0,23495787 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,19501503 0,23483486 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,1982092 0,23855634 ! neuron fate commitment GO:0048663 32 23 0,000 0,1982092 0,23843157 ! embryonic pattern specification GO:0009880 31 23 0,000 0,1982092 0,23830693 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,1982092 0,23818242 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,1982092 0,23805805 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,1982092 0,2379338 ! vesicle targeting GO:0006903 32 23 0,000 0,1982092 0,23780968 ! osteoblast differentiation GO:0001649 40 23 0,000 0,1982092 0,23768569 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,1982092 0,23756183 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,1982092 0,2374381 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,1982092 0,2373145 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,1982092 0,23719103 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,1982092 0,23706769 ! cell fate determination GO:0001709 45 23 0,000 0,1982092 0,23694447 ! pentose metabolic process GO:0019321 31 23 0,000 0,1982092 0,23682138 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,1982092 0,23669842 ! spermatid development GO:0007286 33 23 0,000 0,1982092 0,23657559 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,1982092 0,23645288 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,1982092 0,23633031 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,1982092 0,23620786 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,1982092 0,23608553 ! telomere organization GO:0032200 32 23 0,000 0,1982092 0,23596333 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,1982092 0,23584126 ! regulation of amine transport GO:0051952 38 23 0,000 0,1982092 0,23571932 ! liver development GO:0001889 40 23 0,000 0,1982092 0,2355975 ! cellular defense response GO:0006968 102 87 1,000 0,20196157 0,23993368 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,20544567 0,24394684 ! protein processing GO:0016485 114 88 1,000 0,20544567 0,24382096 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,20587854 0,24420869 ! initiation of viral infection GO:0019059 42 24 0,000 0,20587854 0,24408281 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,20587854 0,24395706 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,20587854 0,24383144 ! superoxide metabolic process GO:0006801 32 24 0,000 0,20587854 0,24370594 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,20587854 0,24358058 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,20587854 0,24345535 ! sperm motility GO:0030317 27 24 0,000 0,20587854 0,24333024 ! vacuole organization GO:0007033 39 24 0,000 0,20587854 0,24320526 ! receptor metabolic process GO:0043112 37 24 0,000 0,20587854 0,24308042 ! neural crest cell development GO:0014032 39 24 0,000 0,20587854 0,2429557 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,20587854 0,2428311 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,20587854 0,24270664 ! base-excision repair GO:0006284 31 24 0,000 0,20587854 0,2425823 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,20587854 0,24245809 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,20587854 0,24233401 ! glutathione metabolic process GO:0006749 29 24 0,000 0,20587854 0,24221005 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,20587854 0,24208622 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,20587854 0,24196252 ! leukocyte differentiation GO:0002521 143 90 1,000 0,21243327 0,24953857 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,21347496 0,25063421 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,21347496 0,25050633 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,21347496 0,25037859 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,21347496 0,25025098 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,21347496 0,25012349 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,21347496 0,24999614 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,21347496 0,24986891 ! peptide transport GO:0015833 43 25 0,000 0,21347496 0,24974182 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,21347496 0,24961485 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,21347496 0,24948802 ! phospholipid transport GO:0015914 35 25 0,000 0,21347496 0,24936131 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,21347496 0,24923473 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,21347496 0,24910828 ! detection of light stimulus GO:0009583 30 25 0,000 0,21347496 0,24898195 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,21347496 0,24885576 GO:0045840|positive regulation of mitosis, ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,21944385 0,25568432 ! cell fate commitment GO:0045165 141 92 1,000 0,21944385 0,25555486 ! DNA recombination GO:0006310 146 92 1,000 0,21944385 0,25542553 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,22099915 0,25710573 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,22099915 0,25697575 ! translational initiation GO:0006413 43 26 0,000 0,22099915 0,2568459 ! regulation of pH GO:0006885 36 26 0,000 0,22099915 0,25671618 ! circadian rhythm GO:0007623 42 26 0,000 0,22099915 0,25658659 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,22099915 0,25645713 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,22099915 0,25632781 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,22099915 0,25619861 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,22099915 0,25606954 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,22099915 0,2559406 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,22295669 0,2580777 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,22295669 0,25794788 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,22845178 0,26417249 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,22845178 0,26403974 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,22845178 0,26390713 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,22845178 0,26377464 ! membrane docking GO:0022406 39 27 0,000 0,22845178 0,26364229 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,22845178 0,26351008 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,22845178 0,26337799 ! acute-phase response GO:0006953 42 27 0,000 0,22845178 0,26324604 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,22845178 0,26311422 ! myofibril assembly GO:0030239 36 27 0,000 0,22845178 0,26298253 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,22845178 0,26285097 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,22845178 0,26271955 ! natural killer cell activation GO:0030101 35 27 0,000 0,22845178 0,26258825 ! lipid oxidation GO:0034440 38 27 0,000 0,22845178 0,26245709 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,22845178 0,26232606 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,22845178 0,26219516 ! gene silencing GO:0016458 41 27 0,000 0,22845178 0,26206438 ! carboxylic acid transport GO:0046942 147 95 1,000 0,22999545 0,26370365 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 1,000 0,23352056 0,267612 ! protein maturation GO:0051604 129 96 1,000 0,23352056 0,26747873 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,23583353 0,26999359 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,23583353 0,26985927 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,23583353 0,26972508 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,23583353 0,26959102 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,23583353 0,26945709 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,23583353 0,2693233 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,23583353 0,26918964 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,23583353 0,26905612 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,23583353 0,26892272 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,23583353 0,26878946 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,23583353 0,26865633 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,23583353 0,26852333 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,23583353 0,26839047 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,23583353 0,26825773 ! mesoderm formation GO:0001707 46 28 0,000 0,23583353 0,26812513 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,23583353 0,26799265 ! BMP signaling pathway GO:0030509 40 28 0,000 0,23583353 0,26786031 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,23583353 0,2677281 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,23583353 0,26759602 ! neural tube formation GO:0001841 41 28 0,000 0,23583353 0,26746407 ! regulation of innate immune response GO:0045088 38 29 0,000 0,24314509 0,27562035 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,24314509 0,27548458 ! protein targeting to membrane GO:0006612 53 29 0,000 0,24314509 0,27534894 ! mismatch repair GO:0006298 34 29 0,000 0,24314509 0,27521343 ! muscle cell development GO:0055001 38 29 0,000 0,24314509 0,27507806 ! formation of primary germ layer GO:0001704 48 29 0,000 0,24314509 0,27494282 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,24314509 0,27480771 ! eye morphogenesis GO:0048592 51 29 0,000 0,24314509 0,27467274 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,24314509 0,2745379 ! calcium ion transport GO:0006816 167 99 1,000 0,24411416 0,27549684 ! protein import GO:0017038 156 99 1,000 0,24411416 0,27536173 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,2476502 0,27921346 ! divalent metal ion transport GO:0070838 171 100 1,000 0,2476502 0,27907666 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,2476502 0,27893999 ! protein localization in organelle GO:0033365 161 100 1,000 0,2476502 0,27880346 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,25038709 0,28174673 ! organic anion transport GO:0015711 51 30 0,000 0,25038709 0,28160896 ! cholesterol transport GO:0030301 46 30 0,000 0,25038709 0,28147132 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,25038709 0,28133381 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,25038709 0,28119644 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,25038709 0,28105921 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,25038709 0,2809221 ! ceramide metabolic process GO:0006672 43 30 0,000 0,25038709 0,28078514 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,25038709 0,2806483 ! adult locomotory behavior GO:0008344 47 30 0,000 0,25038709 0,2805116 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,25038709 0,28037503 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,25038709 0,2802386 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,25038709 0,28010229 ! negative regulation of secretion GO:0051048 49 31 0,000 0,25756022 0,28798663 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,25756022 0,2878467 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,25756022 0,2877069 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,25756022 0,28756723 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,25756022 0,2874277 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,25756022 0,28728831 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,25756022 0,28714905 ! cell fate specification GO:0001708 37 31 0,000 0,25756022 0,28700993 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,25756022 0,28687094 ! RNA modification GO:0009451 40 31 0,000 0,25756022 0,28673209 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,26466511 0,29449915 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,26466511 0,29435674 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,26466511 0,29421447 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,26466511 0,29407234 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,26466511 0,29393035 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,26466511 0,29378849 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,26466511 0,29364677 ! cytokine production GO:0001816 44 32 0,000 0,26466511 0,29350518 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,26466511 0,29336373 ! vesicle localization GO:0051648 47 32 0,000 0,26466511 0,29322242 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,27170241 0,30087412 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,27170241 0,30072933 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,27170241 0,30058468 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,27170241 0,30044016 ! sister chromatid segregation GO:0000819 46 33 0,000 0,27170241 0,30029579 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,27170241 0,30015156 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,27170241 0,30000746 ! lipid homeostasis GO:0055088 55 33 0,000 0,27170241 0,2998635 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,27170241 0,29971968 ! regulation of proteolysis GO:0030162 50 33 0,000 0,27170241 0,299576 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,27170241 0,29943246 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,27170241 0,29928905 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,27170241 0,29914578 ! cytokinesis GO:0000910 52 33 0,000 0,27170241 0,29900265 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,27170241 0,29885966 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,27867276 0,30638019 ! mRNA catabolic process GO:0006402 48 34 0,000 0,27867276 0,30623381 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,27867276 0,30608756 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,27867276 0,30594146 ! feeding behavior GO:0007631 45 34 0,000 0,27867276 0,30579549 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,27867276 0,30564967 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,27867276 0,30550398 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,27867276 0,30535844 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,27867276 0,30521303 ! polyol metabolic process GO:0019751 44 34 0,000 0,27867276 0,30506776 ! aerobic respiration GO:0009060 47 34 0,000 0,27867276 0,30492262 ! embryonic organ development GO:0048568 45 34 0,000 0,27867276 0,30477763 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,2855768 0,31217996 ! Notch signaling pathway GO:0007219 56 35 0,000 0,2855768 0,31203166 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,2855768 0,3118835 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,2855768 0,31173547 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,2855768 0,31158759 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,2855768 0,31143985 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,2855768 0,31129225 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,2855768 0,31114479 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,29241515 0,31844453 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,29241515 0,31829382 ! organic ether metabolic process GO:0018904 46 36 0,000 0,29241515 0,31814326 ! tissue remodeling GO:0048771 62 36 0,000 0,29241515 0,31799283 ! neural tube development GO:0021915 50 36 0,000 0,29241515 0,31784255 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,29241515 0,31769242 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,29241515 0,31754242 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,29918843 0,3247444 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,29918843 0,32459122 ! ion transmembrane transport GO:0034220 56 37 0,000 0,29918843 0,32443819 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,29918843 0,32428529 ! regulation of protein secretion GO:0050708 51 37 0,000 0,29918843 0,32413254 ! amino acid activation GO:0043038 52 37 0,000 0,29918843 0,32397994 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,29918843 0,32382748 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,30589726 0,33093307 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,30589726 0,33077748 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,30589726 0,33062204 ! phagocytosis GO:0006909 60 38 0,000 0,30589726 0,33046675 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,31254225 0,33748693 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,31254225 0,33732856 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,31254225 0,33717034 ! chromatin remodeling GO:0006338 68 39 0,000 0,31254225 0,33701227 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,31254225 0,33685434 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,319124 0,34378698 ! regulation of tube size GO:0035150 60 40 0,000 0,319124 0,34362603 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,319124 0,34346523 ! peptide metabolic process GO:0006518 56 40 0,000 0,319124 0,34330458 ! inner ear development GO:0048839 57 40 0,000 0,319124 0,34314408 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,319124 0,34298374 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,319124 0,34282354 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,319124 0,34266349 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,32564311 0,3495003 ! endosome transport GO:0016197 71 41 0,000 0,32564311 0,34933729 ! striated muscle contraction GO:0006941 62 41 0,000 0,32564311 0,34917443 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,32564311 0,34901172 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,33210017 0,35576636 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,33210017 0,35560074 ! excretion GO:0007588 63 42 0,000 0,33210017 0,35543526 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,33210017 0,35526995 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,33210017 0,35510478 ! tRNA processing GO:0008033 49 43 0,000 0,33849577 0,36177522 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,33849577 0,36160718 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,34483049 0,3682034 ! regulation of ion transport GO:0043269 57 44 0,000 0,34483049 0,36803254 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,34483049 0,36786184 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,34483049 0,3676913 ! RNA catabolic process GO:0006401 64 45 0,000 0,35110491 0,3742082 ! regulation of translational initiation GO:0006446 64 45 0,000 0,35110491 0,37403487 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,35110491 0,37386171 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,35110491 0,3736887 ! cell recognition GO:0008037 58 45 0,000 0,35110491 0,37351586 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,35731959 0,37995149 ! cell redox homeostasis GO:0045454 63 46 0,000 0,35731959 0,37977591 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,35731959 0,37960049 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,35731959 0,37942524 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,36347511 0,38578346 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,36347511 0,38560552 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,36347511 0,38542774 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,36347511 0,38525012 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,36347511 0,38507267 ! chloride transport GO:0006821 67 48 0,000 0,36957202 0,39135159 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,36957202 0,39117149 ! gastrulation GO:0007369 73 48 0,000 0,36957202 0,39099156 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,36957202 0,3908118 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,36957202 0,39063219 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,36957202 0,39045276 ! regulation of endocytosis GO:0030100 63 48 0,000 0,36957202 0,39027349 ! nuclear export GO:0051168 69 48 0,000 0,36957202 0,39009438 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,36957202 0,38991544 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,37561088 0,39610501 ! sensory perception of smell GO:0007608 61 49 0,000 0,37561088 0,39592348 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,37561088 0,39574211 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,37561088 0,39556091 ! RNA elongation GO:0006354 62 49 0,000 0,37561088 0,39537988 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,37561088 0,39519901 ! regulation of actin filament length GO:0030832 72 50 0,000 0,38159224 0,40130871 ! membrane fusion GO:0006944 80 50 0,000 0,38159224 0,4011253 ! proton transport GO:0015992 75 50 0,000 0,38159224 0,40094205 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,38159224 0,40075897 ! positive regulation of secretion GO:0051047 71 51 0,000 0,38751664 0,40679519 ! hydrogen transport GO:0006818 77 51 0,000 0,38751664 0,40660961 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,38751664 0,4064242 ! adult behavior GO:0030534 80 51 0,000 0,38751664 0,40623895 ! transition metal ion transport GO:0000041 74 52 0,000 0,39338461 0,41220256 ! regulation of cellular component size GO:0032535 74 52 0,000 0,39338461 0,41201485 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,39338461 0,41182732 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,39338461 0,41163995 ! establishment of organelle localization GO:0051656 85 52 0,000 0,39338461 0,41145276 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,39919671 0,41734201 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,39919671 0,4171524 ! single fertilization GO:0007338 59 53 0,000 0,39919671 0,41696295 ! regulation of mitosis GO:0007088 84 54 0,000 0,40495344 0,42278389 GO:0051783|regulation of nuclear division, ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,40495344 0,42259207 ! exocytosis GO:0006887 74 55 0,000 0,41065535 0,42834798 ! mesoderm development GO:0007498 76 55 0,000 0,41065535 0,42815381 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,41065535 0,42795981 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,41065535 0,42776599 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,42189673 0,43927681 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,42189673 0,43907804 ! camera-type eye development GO:0043010 88 57 0,000 0,42189673 0,43887945 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,42743723 0,44444197 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,42743723 0,44424113 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,43292495 0,44974136 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,43292495 0,44953832 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,43836038 0,45497693 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,43836038 0,45477171 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,43836038 0,45456667 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,43836038 0,45436182 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,43836038 0,45415715 ! fertilization GO:0009566 68 60 0,000 0,43836038 0,45395267 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,44374402 0,45932099 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,44374402 0,45911437 ! amine catabolic process GO:0009310 90 62 0,000 0,44907636 0,4644225 ! neurotransmitter transport GO:0006836 81 62 0,000 0,44907636 0,46421377 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,44907636 0,46400523 ! organelle localization GO:0051640 96 62 0,000 0,44907636 0,46379687 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,45435789 0,46904091 ! appendage morphogenesis GO:0035107 93 64 0,000 0,45958909 0,47422831 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,45958909 0,47401566 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,45958909 0,47380319 ! adaptive immune response GO:0002250 94 64 0,000 0,45958909 0,47359091 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,46477043 0,47871563 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,46477043 0,47850134 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,46477043 0,47828725 ! activation of immune response GO:0002253 83 65 0,000 0,46477043 0,47807334 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,46990239 0,48313612 ! antigen processing and presentation GO:0019882 96 66 0,000 0,46990239 0,48292024 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,46990239 0,48270456 ! regulation of immune effector process GO:0002697 101 66 0,000 0,46990239 0,48248907 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,47498544 0,48749063 ! acute inflammatory response GO:0002526 92 68 0,000 0,48002003 0,49243803 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,48002003 0,49221849 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,48002003 0,49199914 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,48002003 0,49177999 ! inorganic anion transport GO:0015698 93 68 0,000 0,48002003 0,49156103 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,48500663 0,49644648 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,48500663 0,49622565 ! eye development GO:0001654 111 70 0,000 0,48994569 0,50105607 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,48994569 0,50083338 ! muscle cell differentiation GO:0042692 104 71 0,000 0,49483767 0,50560935 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,49483767 0,50538483 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,49483767 0,50516051 ! regulation of blood pressure GO:0008217 107 73 0,000 0,50448214 0,51477769 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,50923551 0,51939764 ! digestion GO:0007586 97 74 0,000 0,50923551 0,51916741 ! blood coagulation GO:0007596 116 75 0,000 0,51394356 0,52373513 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,51394356 0,52350318 ! tRNA metabolic process GO:0006399 95 76 0,000 0,51860671 0,52801922 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,52322538 0,53248601 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,52322538 0,5322505 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,52322538 0,5320152 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,52780001 0,53642953 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,52780001 0,53619259 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,532331 0,54055687 ! cellular respiration GO:0045333 107 79 0,000 0,532331 0,54031831 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,532331 0,54007997 ! regulation of lyase activity GO:0051339 133 79 0,000 0,532331 0,53984184 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,532331 0,53960392 ! chromatin assembly GO:0031497 102 80 0,000 0,53681877 0,5439133 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,53681877 0,54367379 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,54126374 0,54793424 ! hemostasis GO:0007599 125 81 0,000 0,54126374 0,54769318 ! mRNA transport GO:0051028 121 81 0,000 0,54126374 0,54745233 ! vitamin metabolic process GO:0006766 103 81 0,000 0,54126374 0,54721169 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,55002686 0,55582679 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,55434581 0,55994527 ! sterol metabolic process GO:0016125 120 84 0,000 0,55434581 0,55969946 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,55862356 0,56377104 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,56286049 0,56779786 ! nucleosome organization GO:0034728 114 87 0,000 0,56705699 0,57178039 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,56705699 0,57152983 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,57121344 0,57546689 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,57121344 0,57521494 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,57121344 0,5749632 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,57533023 0,57885368 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,57533023 0,57860058 ! RNA localization GO:0006403 135 91 0,000 0,5834463 0,58650633 ! ATP metabolic process GO:0046034 137 91 0,000 0,5834463 0,5862501 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,58744632 0,59001159 ! positive regulation of immune response GO:0050778 121 92 0,000 0,58744632 0,58975406 ! sulfur metabolic process GO:0006790 118 92 0,000 0,58744632 0,58949675 ! electron transport chain GO:0022900 123 94 0,000 0,59533219 0,5971496 ! angiogenesis GO:0001525 149 95 0,000 0,59921875 0,60078602 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,60306821 0,60438208 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,60688091 0,60793819 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! regulation of translation GO:0006417 151 100 0,000 0,61810195 0,61890923 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,61810195 0,6186399 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,61810195 0,61837081 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,61810195 0,61810195