pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6534-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 9,906E-10 2,278E-06 ! response to UV GO:0009411 75 46 7,000 1,749E-09 2,011E-06 ! apoptotic mitochondrial changes GO:0008637 29 18 5,000 2,848E-09 2,184E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 7,000 4,135E-09 2,378E-06 ! interphase of mitotic cell cycle GO:0051329 156 86 8,000 1,706E-08 7,846E-06 ! interphase GO:0051325 159 88 8,000 2,092E-08 8,021E-06 ! response to light stimulus GO:0009416 153 96 8,000 4,513E-08 1,483E-05 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 3,000 1,068E-07 3,071E-05 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 4,000 1,309E-07 3,344E-05 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 3,000 2,124E-07 4,884E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 3,000 2,124E-07 4,44E-05 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 3,000 2,124E-07 4,07E-05 ! cell structure disassembly during apoptosis GO:0006921 24 19 4,000 2,429E-07 4,298E-05 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 4,000 3,22E-07 5,289E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 5,14E-07 7,881E-05 ! regulation of B cell proliferation GO:0030888 15 10 3,000 6,296E-07 9,051E-05 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 8,615E-07 1,166E-04 ! homophilic cell adhesion GO:0007156 149 100 7,000 8,869E-07 1,133E-04 ! negative regulation of mast cell proliferation GO:0070667 17 11 3,000 9,836E-07 1,191E-04 GO:0042130|negative regulation of T cell proliferation, ! positive regulation of cell cycle GO:0045787 77 45 5,000 1,057E-06 1,216E-04 ! negative regulation of blood coagulation GO:0030195 19 14 3,000 2,932E-06 3,211E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 2,932E-06 3,065E-04 ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 3,608E-06 3,608E-04 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 3,000 3,974E-06 3,809E-04 ! negative regulation of leukocyte proliferation GO:0070664 25 15 3,000 3,974E-06 3,656E-04 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! cellular response to insulin stimulus GO:0032869 52 34 4,000 5,308E-06 4,696E-04 ! negative regulation of coagulation GO:0050819 23 17 3,000 6,849E-06 5,834E-04 ! regulation of helicase activity GO:0051095 11 6 2,000 8,277E-06 6,799E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 8,277E-06 6,565E-04 ! ER overload response GO:0006983 7 6 2,000 8,277E-06 6,346E-04 ! negative regulation of B cell activation GO:0050869 9 6 2,000 8,277E-06 6,141E-04 ! negative regulation of T cell activation GO:0050868 25 18 3,000 8,754E-06 6,292E-04 ! apoptotic nuclear changes GO:0030262 24 19 3,000 1,102E-05 7,683E-04 ! energy reserve metabolic process GO:0006112 59 41 4,000 1,37E-05 9,27E-04 ! fibrinolysis GO:0042730 9 7 2,000 1,441E-05 9,466E-04 ! cellular component disassembly GO:0022411 64 42 4,000 1,546E-05 9,878E-04 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 3,000 1,682E-05 1,046E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 3,000 1,682E-05 1,018E-03 ! response to insulin stimulus GO:0032868 63 43 4,000 1,739E-05 1,026E-03 ! mitochondrion organization GO:0007005 104 73 5,000 1,859E-05 1,069E-03 ! regulation of mast cell proliferation GO:0070666 64 44 4,000 1,95E-05 1,094E-03 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 2,011E-05 1,101E-03 ! regulation of blood coagulation GO:0030193 34 22 3,000 2,044E-05 1,093E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 2,181E-05 1,14E-03 ! middle ear morphogenesis GO:0042474 9 8 2,000 2,292E-05 1,172E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 2,292E-05 1,146E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 3,000 2,46E-05 1,204E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 2,46E-05 1,179E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 4,000 2,705E-05 1,27E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 3,474E-05 1,598E-03 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of lymphocyte activation GO:0051250 37 25 3,000 3,474E-05 1,566E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 3,000 4,081E-05 1,805E-03 ! regulation of coagulation GO:0050818 39 26 3,000 4,081E-05 1,771E-03 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 4,437E-05 1,89E-03 ! negative regulation of multicellular organismal process GO:0051241 133 85 5,000 4,437E-05 1,855E-03 ! cell cycle arrest GO:0007050 150 86 5,000 4,74E-05 1,947E-03 ! negative regulation of leukocyte activation GO:0002695 39 27 3,000 4,763E-05 1,922E-03 ! positive regulation of catabolic process GO:0009896 40 28 3,000 5,524E-05 2,191E-03 ! regulation of B cell activation GO:0050864 42 28 3,000 5,524E-05 2,154E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 6,642E-05 2,546E-03 ! T cell homeostasis GO:0043029 20 11 2,000 6,642E-05 2,504E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 6,951E-05 2,579E-03 ! negative regulation of cell activation GO:0050866 44 30 3,000 7,308E-05 2,668E-03 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 7,361E-05 2,645E-03 ! angiogenesis GO:0001525 149 95 5,000 8,291E-05 2,934E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 8,807E-05 3,069E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 5,000 1,043E-04 3,58E-03 ! nucleus organization GO:0006997 49 33 3,000 1,072E-04 3,627E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 1,139E-04 3,795E-03 ! lymphocyte homeostasis GO:0002260 24 13 2,000 1,139E-04 3,741E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 1,214E-04 3,931E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 1,792E-04 5,723E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,792E-04 5,645E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 1,858E-04 5,775E-03 ! regulation of catabolic process GO:0009894 106 70 4,000 1,858E-04 5,698E-03 ! regulation of T cell proliferation GO:0042129 58 38 3,000 1,879E-04 5,685E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 2,122E-04 6,339E-03 GO:0045937|positive regulation of phosphate metabolic process, ! patterning of blood vessels GO:0001569 24 16 2,000 2,193E-04 6,466E-03 ! glucose transport GO:0015758 52 41 3,000 2,533E-04 7,373E-03 ! positive regulation of hormone secretion GO:0046887 24 17 2,000 2,648E-04 7,613E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 2,648E-04 7,519E-03 ! regulation of protein transport GO:0051223 114 76 4,000 2,735E-04 7,673E-03 GO:0070201|regulation of establishment of protein localization, ! hexose transport GO:0008645 54 42 3,000 2,783E-04 7,712E-03 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 3,000 2,783E-04 7,62E-03 ! activation of caspase activity GO:0006919 65 43 3,000 3,051E-04 8,254E-03 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 3,732E-04 9,981E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 3,732E-04 9,866E-03 ! negative regulation of immune system process GO:0002683 73 47 3,000 4,307E-04 0,01125781 ! camera-type eye morphogenesis GO:0048593 34 20 2,000 4,366E-04 0,01128393 ! regulation of protein localization GO:0032880 132 85 4,000 4,601E-04 0,01175792 ! positive regulation of caspase activity GO:0043280 72 48 3,000 4,672E-04 0,01180741 GO:0010952|positive regulation of peptidase activity, ! regulation of DNA replication GO:0006275 75 48 3,000 4,672E-04 0,01167907 ! morphogenesis of a branching structure GO:0001763 86 49 3,000 5,057E-04 0,01250742 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 5,066E-04 0,01239573 ! gluconeogenesis GO:0006094 25 21 2,000 5,066E-04 0,01226525 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 5,066E-04 0,01213749 ! regulation of vasoconstriction GO:0019229 31 21 2,000 5,066E-04 0,01201236 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 5,066E-04 0,01188978 ! ear development GO:0043583 72 50 3,000 5,465E-04 0,01269696 ! positive regulation of growth GO:0045927 67 50 3,000 5,465E-04 0,01256999 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 1,000 5,575E-04 0,01269469 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 1,000 5,575E-04 0,01257024 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,575E-04 0,0124482 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 5,575E-04 0,0123285 ! positive regulation of glycolysis GO:0045821 11 5 1,000 5,575E-04 0,01221109 ! anagen GO:0042640 6 5 1,000 5,575E-04 0,01209589 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 5,575E-04 0,01198284 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 1,000 5,575E-04 0,01187189 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 5,575E-04 0,01176297 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 5,575E-04 0,01165604 ! microvillus organization GO:0032528 7 5 1,000 5,575E-04 0,01155103 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 1,000 5,575E-04 0,01144789 ! response to food GO:0032094 5 5 1,000 5,575E-04 0,01134659 ! melanosome organization GO:0032438 7 5 1,000 5,575E-04 0,01124705 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 5,575E-04 0,01114925 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 5,575E-04 0,01105314 GO:0045686|negative regulation of glial cell differentiation, ! regulation of respiratory burst GO:0060263 8 5 1,000 5,575E-04 0,01095867 ! apical protein localization GO:0045176 6 5 1,000 5,575E-04 0,0108658 ! determination of adult lifespan GO:0008340 8 5 1,000 5,575E-04 0,01077449 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 5,834E-04 0,01118128 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 5,834E-04 0,01108888 ! leukocyte homeostasis GO:0001776 33 22 2,000 5,834E-04 0,01099798 ! protein tetramerization GO:0051262 39 22 2,000 5,834E-04 0,01090857 ! positive regulation of cell migration GO:0030335 92 51 3,000 5,896E-04 0,01093598 ! regulation of protein catabolic process GO:0042176 77 51 3,000 5,896E-04 0,01084849 ! aging GO:0007568 79 52 3,000 6,35E-04 0,01159162 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 6,672E-04 0,01208291 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 6,672E-04 0,01198851 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 6,672E-04 0,01189558 ! DNA catabolic process GO:0006308 67 54 3,000 7,332E-04 0,01297246 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 7,583E-04 0,01331378 ! pyruvate metabolic process GO:0006090 29 24 2,000 7,583E-04 0,01321292 ! negative regulation of cell development GO:0010721 56 24 2,000 7,583E-04 0,01311357 GO:0050768|negative regulation of neurogenesis, ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 7,583E-04 0,01301571 ! prostate gland development GO:0030850 9 6 1,000 8,321E-04 0,01417576 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 8,321E-04 0,01407152 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 8,321E-04 0,01396881 ! inositol phosphate-mediated signaling GO:0048016 9 6 1,000 8,321E-04 0,01386759 ! pigment granule organization GO:0048753 11 6 1,000 8,321E-04 0,01376782 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 8,321E-04 0,01366948 ! vascular smooth muscle contraction GO:0014829 10 6 1,000 8,321E-04 0,01357253 ! positive regulation of muscle hypertrophy GO:0014742 9 6 1,000 8,321E-04 0,01347695 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 8,321E-04 0,01338271 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 8,321E-04 0,01328977 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 8,321E-04 0,01319812 ! neuron apoptosis GO:0051402 8 6 1,000 8,321E-04 0,01310772 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 8,321E-04 0,01301855 ! male sex determination GO:0030238 9 6 1,000 8,321E-04 0,01293059 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 8,321E-04 0,01284381 ! negative regulation of DNA recombination GO:0045910 9 6 1,000 8,321E-04 0,01275818 ! establishment of melanosome localization GO:0032401 9 6 1,000 8,321E-04 0,01267369 ! hair follicle maturation GO:0048820 7 6 1,000 8,321E-04 0,01259031 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 8,321E-04 0,01250802 ! progesterone metabolic process GO:0042448 8 6 1,000 8,321E-04 0,0124268 ! positive regulation of smooth muscle contraction GO:0045987 9 6 1,000 8,321E-04 0,01234663 ! positive regulation of cell motion GO:0051272 99 56 3,000 8,417E-04 0,01240989 ! iron ion homeostasis GO:0055072 39 25 2,000 8,57E-04 0,01255442 ! positive regulation of nuclear division GO:0051785 39 25 2,000 8,57E-04 0,01247496 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 8,57E-04 0,0123965 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 9E-04 0,0129374 ! carbohydrate transport GO:0008643 74 57 3,000 9E-04 0,01285705 ! negative regulation of kinase activity GO:0033673 100 58 3,000 9,611E-04 0,01364465 ! regulation of pH GO:0006885 36 26 2,000 9,634E-04 0,01359443 ! activation of MAPK activity GO:0000187 84 59 3,000 1,025E-03 0,01437473 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 1,000 1,159E-03 0,01615737 GO:0016446|somatic hypermutation of immunoglobulin genes, ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,159E-03 0,01606003 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,159E-03 0,01596386 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,159E-03 0,01586884 ! microtubule bundle formation GO:0001578 8 7 1,000 1,159E-03 0,01577494 ! positive regulation of heart rate GO:0010460 9 7 1,000 1,159E-03 0,01568215 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 1,159E-03 0,01559044 GO:0021940|positive regulation of granule cell precursor proliferation, ! phasic smooth muscle contraction GO:0014821 12 7 1,000 1,159E-03 0,0154998 ! asymmetric protein localization GO:0008105 8 7 1,000 1,159E-03 0,0154102 ! retinol metabolic process GO:0042572 9 7 1,000 1,159E-03 0,01532164 ! protein heterooligomerization GO:0051291 10 7 1,000 1,159E-03 0,01523409 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,159E-03 0,01514753 ! B cell lineage commitment GO:0002326 17 7 1,000 1,159E-03 0,01506195 ! melanosome localization GO:0032400 10 7 1,000 1,159E-03 0,01497733 ! multicellular organismal aging GO:0010259 11 7 1,000 1,159E-03 0,01489366 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 1,159E-03 0,01481092 ! T cell lineage commitment GO:0002360 12 7 1,000 1,159E-03 0,01472909 ! response to tumor cell GO:0002347 12 7 1,000 1,159E-03 0,01464816 ! neuroblast proliferation GO:0007405 13 7 1,000 1,159E-03 0,01456812 ! diuresis GO:0030146 12 7 1,000 1,159E-03 0,01448894 GO:0030147|natriuresis, ! establishment of pigment granule localization GO:0051905 13 7 1,000 1,159E-03 0,01441062 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 1,000 1,159E-03 0,01433315 ! negative regulation of transferase activity GO:0051348 105 61 3,000 1,162E-03 0,01428813 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 1,201E-03 0,01468851 ! negative regulation of cell growth GO:0030308 106 62 3,000 1,235E-03 0,01502441 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 1,311E-03 0,01586621 ! hexose biosynthetic process GO:0019319 35 29 2,000 1,332E-03 0,01603749 ! eye morphogenesis GO:0048592 51 29 2,000 1,332E-03 0,01595396 ! tissue homeostasis GO:0001894 42 29 2,000 1,332E-03 0,0158713 GO:0048871|multicellular organismal homeostasis, ! cell cycle checkpoint GO:0000075 108 64 3,000 1,39E-03 0,0164791 ! regulation of caspase activity GO:0043281 97 65 3,000 1,473E-03 0,01736858 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,538E-03 0,01804616 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,538E-03 0,01795456 ! succinate metabolic process GO:0006105 14 8 1,000 1,538E-03 0,01786388 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,538E-03 0,01777411 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,538E-03 0,01768524 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 1,000 1,538E-03 0,01759725 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,538E-03 0,01751014 ! regulation of muscle hypertrophy GO:0014743 11 8 1,000 1,538E-03 0,01742388 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! lens development in camera-type eye GO:0002088 10 8 1,000 1,538E-03 0,01733847 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,538E-03 0,01725389 GO:0045685|regulation of glial cell differentiation, ! pigment granule localization GO:0051875 14 8 1,000 1,538E-03 0,01717013 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,538E-03 0,01708719 ! regulation of embryonic development GO:0045995 16 8 1,000 1,538E-03 0,01700504 ! negative regulation of secretion GO:0051048 49 31 2,000 1,62E-03 0,01783225 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 1,648E-03 0,01804796 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 1,778E-03 0,01938357 ! monovalent inorganic cation homeostasis GO:0055067 45 32 2,000 1,778E-03 0,01929214 ! calcium-mediated signaling GO:0019722 50 32 2,000 1,778E-03 0,01920157 ! monosaccharide biosynthetic process GO:0046364 38 32 2,000 1,778E-03 0,01911184 ! activation of protein kinase activity GO:0032147 102 69 3,000 1,837E-03 0,01965341 ! ear morphogenesis GO:0042471 42 33 2,000 1,945E-03 0,02071419 ! carbohydrate homeostasis GO:0033500 39 33 2,000 1,945E-03 0,02061873 GO:0042593|glucose homeostasis, ! regulation of proteolysis GO:0030162 50 33 2,000 1,945E-03 0,02052415 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,945E-03 0,02043043 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 1,967E-03 0,02056893 ! regulation of developmental growth GO:0048638 13 9 1,000 1,967E-03 0,02047586 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,967E-03 0,02038362 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 1,967E-03 0,02029222 GO:0010469|regulation of receptor activity, ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 1,967E-03 0,02020163 ! regulation of glycolysis GO:0006110 15 9 1,000 1,967E-03 0,02011184 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,967E-03 0,02002285 GO:0006600|creatine metabolic process, ! positive regulation of muscle contraction GO:0045933 12 9 1,000 1,967E-03 0,01993464 ! motor axon guidance GO:0008045 14 9 1,000 1,967E-03 0,01984721 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,967E-03 0,01976054 ! renal water homeostasis GO:0003091 14 9 1,000 1,967E-03 0,01967463 ! oocyte differentiation GO:0009994 12 9 1,000 1,967E-03 0,01958945 GO:0048599|oocyte development, ! regulation of muscle adaptation GO:0043502 12 9 1,000 1,967E-03 0,01950502 ! localization within membrane GO:0051668 15 9 1,000 1,967E-03 0,01942131 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 2,122E-03 0,02085627 ! regulation of peptidase activity GO:0052547 106 72 3,000 2,149E-03 0,02102909 ! response to hypoxia GO:0001666 132 72 3,000 2,149E-03 0,02093998 ! negative regulation of transport GO:0051051 116 73 3,000 2,26E-03 0,02193302 ! tube morphogenesis GO:0035239 118 73 3,000 2,26E-03 0,02184086 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 2,308E-03 0,02221197 ! keratinocyte differentiation GO:0030216 47 35 2,000 2,308E-03 0,02211942 ! glycogen metabolic process GO:0005977 48 35 2,000 2,308E-03 0,02202764 ! response to oxygen levels GO:0070482 137 74 3,000 2,375E-03 0,02257617 ! hippocampus development GO:0021766 19 10 1,000 2,447E-03 0,02316265 ! positive regulation of heart contraction GO:0045823 14 10 1,000 2,447E-03 0,02306772 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,447E-03 0,02297357 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,447E-03 0,02288018 ! glucan biosynthetic process GO:0009250 13 10 1,000 2,447E-03 0,02278755 GO:0005978|glycogen biosynthetic process, ! response to X-ray GO:0010165 16 10 1,000 2,447E-03 0,02269566 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 2,447E-03 0,02260452 ! multicellular organismal water homeostasis GO:0050891 15 10 1,000 2,447E-03 0,0225141 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,447E-03 0,0224244 GO:0043470|regulation of carbohydrate catabolic process, ! negative regulation of growth GO:0045926 123 75 3,000 2,495E-03 0,02276952 ! regulation of hormone secretion GO:0046883 48 36 2,000 2,504E-03 0,02276503 ! glucan metabolic process GO:0044042 49 36 2,000 2,504E-03 0,0226754 GO:0006073|cellular glucan metabolic process, ! regulation of protein secretion GO:0050708 51 37 2,000 2,71E-03 0,02444485 ! carbohydrate biosynthetic process GO:0016051 97 77 3,000 2,746E-03 0,02466817 ! alcohol biosynthetic process GO:0046165 45 38 2,000 2,926E-03 0,02618948 ! pigmentation GO:0043473 74 38 2,000 2,926E-03 0,02608797 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 2,976E-03 0,02642996 ! virus-host interaction GO:0019048 17 11 1,000 2,976E-03 0,0263283 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,976E-03 0,02622743 ! negative regulation of proteolysis GO:0045861 16 11 1,000 2,976E-03 0,02612732 ! regulation of mRNA processing GO:0050684 18 11 1,000 2,976E-03 0,02602798 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,976E-03 0,02592939 ! vasoconstriction GO:0042310 15 11 1,000 2,976E-03 0,02583154 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 1,000 2,976E-03 0,02573443 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! negative regulation of protein complex disassembly GO:0043242 67 39 2,000 3,153E-03 0,02715993 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 3,153E-03 0,02705858 ! cell growth GO:0016049 61 39 2,000 3,153E-03 0,02695799 ! regulation of cell cycle process GO:0010564 122 81 3,000 3,298E-03 0,0280974 ! epidermal cell differentiation GO:0009913 53 40 2,000 3,39E-03 0,0287705 ! positive regulation of protein transport GO:0051222 55 40 2,000 3,39E-03 0,02866472 ! ossification GO:0001503 134 82 3,000 3,448E-03 0,02904534 GO:0060348|bone development, ! cartilage condensation GO:0001502 18 12 1,000 3,554E-03 0,02983181 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,554E-03 0,02972333 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! immunoglobulin production during immune response GO:0002381 20 12 1,000 3,554E-03 0,02961564 ! histone acetylation GO:0016573 23 12 1,000 3,554E-03 0,02950872 ! peptidyl-lysine modification GO:0018205 18 12 1,000 3,554E-03 0,02940258 ! response to gamma radiation GO:0010332 20 12 1,000 3,554E-03 0,02929719 ! cAMP biosynthetic process GO:0006171 20 12 1,000 3,554E-03 0,02919256 ! regulation of T cell differentiation GO:0045580 59 41 2,000 3,638E-03 0,02977351 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 3,896E-03 0,03177548 ! transcription initiation GO:0006352 118 85 3,000 3,922E-03 0,03187866 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 4,165E-03 0,0337328 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 4,179E-03 0,03372796 ! bone mineralization GO:0030282 15 13 1,000 4,179E-03 0,03361003 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 4,179E-03 0,03349292 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 4,179E-03 0,03337662 ! genitalia development GO:0048806 15 13 1,000 4,179E-03 0,03326113 ! regulation of cellular pH GO:0030641 20 13 1,000 4,179E-03 0,03314644 ! cellular pigmentation GO:0033059 24 13 1,000 4,179E-03 0,03303253 ! anatomical structure homeostasis GO:0060249 136 88 3,000 4,44E-03 0,03497125 ! reproductive developmental process GO:0003006 127 89 3,000 4,622E-03 0,03628202 ! regulation of T cell activation GO:0050863 128 89 3,000 4,622E-03 0,03615861 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 4,852E-03 0,03782814 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,852E-03 0,03770034 ! retina development in camera-type eye GO:0060041 18 14 1,000 4,852E-03 0,0375734 ! limbic system development GO:0021761 25 14 1,000 4,852E-03 0,03744732 ! activation of MAPKK activity GO:0000186 21 14 1,000 4,852E-03 0,03732207 ! cellular response to starvation GO:0009267 21 14 1,000 4,852E-03 0,03719767 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 4,852E-03 0,03707409 GO:0031114|regulation of microtubule depolymerization, ! regulation of heart rate GO:0002027 23 14 1,000 4,852E-03 0,03695133 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 4,852E-03 0,03682937 ! G1/S transition checkpoint GO:0031575 33 14 1,000 4,852E-03 0,03670822 ! water homeostasis GO:0030104 24 14 1,000 4,852E-03 0,03658787 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 1,000 4,852E-03 0,0364683 ! peptide hormone secretion GO:0030072 23 14 1,000 4,852E-03 0,03634951 ! regulation of protein complex disassembly GO:0043244 77 46 2,000 5,04E-03 0,03763653 ! regulation of cytoskeleton organization GO:0051493 154 93 3,000 5,401E-03 0,04020191 ! positive regulation of cell size GO:0045793 20 15 1,000 5,571E-03 0,04133136 ! negative regulation of hormone secretion GO:0046888 20 15 1,000 5,571E-03 0,04119847 ! lipid phosphorylation GO:0046834 23 15 1,000 5,571E-03 0,04106642 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 5,571E-03 0,04093522 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 5,571E-03 0,04080485 ! regulation of muscle cell differentiation GO:0051147 24 15 1,000 5,571E-03 0,04067531 ! positive regulation of proteolysis GO:0045862 19 15 1,000 5,571E-03 0,04054659 ! cardiac muscle tissue development GO:0048738 23 15 1,000 5,571E-03 0,04041868 ! response to osmotic stress GO:0006970 22 15 1,000 5,571E-03 0,04029158 ! peptide secretion GO:0002790 27 15 1,000 5,571E-03 0,04016527 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 5,571E-03 0,04003976 ! biomineral formation GO:0031214 18 15 1,000 5,571E-03 0,03991502 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 5,571E-03 0,03979106 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 5,571E-03 0,03966787 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 5,68E-03 0,04032171 ! heart morphogenesis GO:0003007 65 48 2,000 5,68E-03 0,04019764 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 5,68E-03 0,04007433 ! regulation of angiogenesis GO:0045765 94 49 2,000 6,018E-03 0,04232534 ! regulation of intracellular transport GO:0032386 78 49 2,000 6,018E-03 0,0421963 ! germ cell development GO:0007281 68 49 2,000 6,018E-03 0,04206805 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 6,018E-03 0,04194057 ! cartilage development GO:0051216 70 49 2,000 6,018E-03 0,04181386 ! regulation of response to external stimulus GO:0032101 139 96 3,000 6,04E-03 0,04184183 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 6,335E-03 0,04375694 ! hormone secretion GO:0046879 25 16 1,000 6,335E-03 0,04362593 ! protein amino acid acetylation GO:0006473 28 16 1,000 6,335E-03 0,04349571 ! cellular response to unfolded protein GO:0034620 19 16 1,000 6,335E-03 0,04336626 GO:0030968|endoplasmic reticulum unfolded protein response, ! DNA replication initiation GO:0006270 25 16 1,000 6,335E-03 0,04323757 ! oogenesis GO:0048477 23 16 1,000 6,335E-03 0,04310965 ! G1 phase GO:0051318 27 16 1,000 6,335E-03 0,04298248 ! neutrophil chemotaxis GO:0030593 21 16 1,000 6,335E-03 0,04285606 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 6,335E-03 0,04273039 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 6,335E-03 0,04260544 ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 1,000 6,335E-03 0,04248123 ! negative regulation of translation GO:0017148 22 16 1,000 6,335E-03 0,04235774 ! negative regulation of cytoskeleton organization GO:0051494 84 50 2,000 6,367E-03 0,04244517 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 6,367E-03 0,04232249 ! positive regulation of secretion GO:0051047 71 51 2,000 6,728E-03 0,04459381 ! activation of phospholipase C activity GO:0007202 87 51 2,000 6,728E-03 0,04446567 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 2,000 6,728E-03 0,04433826 ! regulation of body fluid levels GO:0050878 154 100 3,000 6,967E-03 0,04578323 ! positive regulation of phospholipase activity GO:0010518 88 52 2,000 7,101E-03 0,04652998 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 7,145E-03 0,04668371 ! keratinization GO:0031424 17 17 1,000 7,145E-03 0,04655146 ! retinoid metabolic process GO:0001523 22 17 1,000 7,145E-03 0,04641996 GO:0016101|diterpenoid metabolic process, ! actin filament bundle formation GO:0051017 26 17 1,000 7,145E-03 0,04628919 ! neuromuscular junction development GO:0007528 23 17 1,000 7,145E-03 0,04615917 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 7,145E-03 0,04602987 ! body fluid secretion GO:0007589 27 17 1,000 7,145E-03 0,0459013 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 7,145E-03 0,04577344 ! vitamin A metabolic process GO:0006776 22 17 1,000 7,145E-03 0,04564629 ! cell-cell junction organization GO:0045216 25 17 1,000 7,145E-03 0,04551985 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 7,145E-03 0,0453941 ! skeletal system morphogenesis GO:0048705 78 53 2,000 7,486E-03 0,0474317 ! regulation of mitosis GO:0007088 84 54 2,000 7,883E-03 0,0498113 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 2,000 7,883E-03 0,04967483 ! positive regulation of lipase activity GO:0060193 90 54 2,000 7,883E-03 0,0495391 ! positive regulation of DNA replication GO:0045740 29 18 1,000 7,998E-03 0,05012505 ! cAMP metabolic process GO:0046058 33 18 1,000 7,998E-03 0,04998884 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 7,998E-03 0,04985337 GO:0050886|endocrine process, ! response to retinoic acid GO:0032526 25 18 1,000 7,998E-03 0,04971863 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 7,998E-03 0,04958462 ! peptide cross-linking GO:0018149 31 18 1,000 7,998E-03 0,04945133 ! somitogenesis GO:0001756 24 18 1,000 7,998E-03 0,04931875 ! cellular response to nutrient levels GO:0031669 27 18 1,000 7,998E-03 0,04918688 ! vitamin transport GO:0051180 24 18 1,000 7,998E-03 0,04905572 ! hormone transport GO:0009914 27 18 1,000 7,998E-03 0,04892525 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 7,998E-03 0,04879547 ! terpenoid metabolic process GO:0006721 24 18 1,000 7,998E-03 0,04866639 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 7,998E-03 0,04853798 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 8,714E-03 0,05274489 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 8,895E-03 0,05369851 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 8,895E-03 0,05355794 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 8,895E-03 0,0534181 GO:0010675|regulation of cellular carbohydrate metabolic process, ! C21-steroid hormone metabolic process GO:0008207 23 19 1,000 8,895E-03 0,05327899 ! response to alkaloid GO:0043279 32 19 1,000 8,895E-03 0,05314061 ! smooth muscle contraction GO:0006939 36 19 1,000 8,895E-03 0,05300294 ! digestive system process GO:0022600 30 19 1,000 8,895E-03 0,05286598 ! response to vitamin A GO:0033189 26 19 1,000 8,895E-03 0,05272973 ! response to starvation GO:0042594 30 19 1,000 8,895E-03 0,05259417 ! sex determination GO:0007530 29 19 1,000 8,895E-03 0,05245932 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 8,895E-03 0,05232515 ! cytolysis GO:0019835 20 19 1,000 8,895E-03 0,05219167 ! renal system process GO:0003014 35 19 1,000 8,895E-03 0,05205886 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 8,895E-03 0,05192673 ! somatic diversification of immunoglobulins GO:0016445 29 19 1,000 8,895E-03 0,05179527 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 8,895E-03 0,05166448 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 8,895E-03 0,05153434 ! camera-type eye development GO:0043010 88 57 2,000 9,149E-03 0,05286825 ! developmental maturation GO:0021700 75 57 2,000 9,149E-03 0,05273574 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 9,595E-03 0,05517179 ! iron ion transport GO:0006826 37 20 1,000 9,835E-03 0,05641094 ! response to vitamin GO:0033273 29 20 1,000 9,835E-03 0,05627061 ! pallium development GO:0021543 38 20 1,000 9,835E-03 0,05613098 ! positive regulation of B cell activation GO:0050871 31 20 1,000 9,835E-03 0,05599204 ! lung development GO:0030324 94 59 2,000 0,01005421 0,05709796 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01081707 0,06127898 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 1,000 0,01081707 0,06112842 GO:0016444|somatic cell DNA recombination, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01081707 0,0609786 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01081707 0,06082951 ! dendrite development GO:0016358 35 21 1,000 0,01081707 0,06068114 ! regulation of DNA recombination GO:0000018 40 21 1,000 0,01081707 0,0605335 ! cell aging GO:0007569 32 21 1,000 0,01081707 0,06038657 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01081707 0,06024036 ! regulation of insulin secretion GO:0050796 26 21 1,000 0,01081707 0,06009485 ! immunoglobulin production GO:0002377 33 21 1,000 0,01081707 0,05995004 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 26 21 1,000 0,01081707 0,05980593 ! meiosis GO:0007126 96 61 2,000 0,01101027 0,06072809 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 0,01101027 0,06058281 ! urogenital system development GO:0001655 101 61 2,000 0,01101027 0,06043822 ! homeostasis of number of cells GO:0048872 84 61 2,000 0,01101027 0,06029432 ! cellular hormone metabolic process GO:0034754 87 62 2,000 0,01150733 0,06286667 ! respiratory tube development GO:0030323 99 62 2,000 0,01150733 0,06271769 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01150733 0,06256943 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01184044 0,06422882 ! molting cycle process GO:0022404 40 22 1,000 0,01184044 0,06407769 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01184044 0,06392727 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01184044 0,06377756 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01184044 0,06362855 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 0,01184044 0,06348023 ! membrane depolarization GO:0051899 35 22 1,000 0,01184044 0,0633326 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 0,01184044 0,06318566 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,01201717 0,06398028 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,01201717 0,06383252 ! regulation of lipase activity GO:0060191 109 63 2,000 0,01201717 0,06368544 ! regulation of actin cytoskeleton organization GO:0032956 97 64 2,000 0,01253981 0,06630247 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 0,01253981 0,0661504 ! respiratory system development GO:0060541 100 64 2,000 0,01253981 0,06599902 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01290456 0,06776369 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01290456 0,06760933 ! myelination GO:0042552 35 23 1,000 0,01290456 0,06745567 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01290456 0,06730271 ! interaction with host GO:0051701 37 23 1,000 0,01290456 0,06715044 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 0,01290456 0,06699886 ! fat-soluble vitamin metabolic process GO:0006775 28 23 1,000 0,01290456 0,06684796 ! somatic diversification of immune receptors GO:0002200 35 23 1,000 0,01290456 0,06669774 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01290456 0,06654819 ! reproductive structure development GO:0048608 90 65 2,000 0,01307533 0,06727797 ! B cell activation GO:0042113 104 65 2,000 0,01307533 0,0671278 ! protein oligomerization GO:0051259 100 65 2,000 0,01307533 0,06697829 ! regulation of actin filament-based process GO:0032970 99 66 2,000 0,01362375 0,06963249 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,01362375 0,06947809 ! fat cell differentiation GO:0045444 37 24 1,000 0,01400877 0,07128355 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01400877 0,07112619 ! neural crest cell development GO:0014032 39 24 1,000 0,01400877 0,07096953 GO:0014033|neural crest cell differentiation, ! base-excision repair GO:0006284 31 24 1,000 0,01400877 0,07081355 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01400877 0,07065826 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,01400877 0,07050365 ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 0,0151524 0,07609285 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,0151524 0,07592707 ! peptide transport GO:0015833 43 25 1,000 0,0151524 0,07576201 ! regulation of peptide secretion GO:0002791 34 25 1,000 0,0151524 0,07559767 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 1,000 0,0151524 0,07543404 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,0151524 0,07527111 ! response to drug GO:0042493 108 69 2,000 0,01534685 0,07607276 ! eye development GO:0001654 111 70 2,000 0,01594728 0,07887903 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 2,000 0,01594728 0,07870976 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01633482 0,08044984 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 1,000 0,01633482 0,08027794 ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,01633482 0,08010677 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01633482 0,07993633 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01656079 0,08087011 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01718741 0,0837522 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 0,01755537 0,08536437 ! respiratory gaseous exchange GO:0007585 47 27 1,000 0,01755537 0,08518428 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01755537 0,08500494 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,01755537 0,08482636 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01755537 0,08464853 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01755537 0,08447144 ! protein import into nucleus GO:0006606 118 74 2,000 0,01848004 0,08873507 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01881343 0,09014767 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,01881343 0,08996025 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01881343 0,08977361 GO:0008366|axon ensheathment, ! placenta development GO:0001890 37 28 1,000 0,01881343 0,08958774 ! blood coagulation GO:0007596 116 75 2,000 0,0191461 0,09098352 GO:0050817|coagulation, ! nuclear import GO:0051170 121 75 2,000 0,0191461 0,09079592 ! mismatch repair GO:0006298 34 29 1,000 0,02010836 0,09516302 ! telencephalon development GO:0021537 52 29 1,000 0,02010836 0,09496762 ! regulation of DNA binding GO:0051101 119 77 2,000 0,02051775 0,09670249 ! gland development GO:0048732 148 77 2,000 0,02051775 0,09650474 ! sex differentiation GO:0007548 105 77 2,000 0,02051775 0,09630779 ! protein ubiquitination GO:0016567 125 77 2,000 0,02051775 0,09611164 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,02122336 0,09921489 ! spliceosome assembly GO:0000245 49 30 1,000 0,02143955 0,10002226 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,02143955 0,09981978 ! response to heat GO:0009408 41 30 1,000 0,02143955 0,09961813 ! establishment of vesicle localization GO:0051650 45 30 1,000 0,02143955 0,09941728 ! protein localization in nucleus GO:0034504 133 80 2,000 0,02267419 0,10493088 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02280639 0,10533072 ! mammary gland development GO:0030879 57 31 1,000 0,02280639 0,10511964 ! segmentation GO:0035282 41 31 1,000 0,02280639 0,1049094 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02280639 0,1047 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02280639 0,10449143 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02280639 0,10428369 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,02280639 0,10407678 GO:0060326|cell chemotaxis, ! hemostasis GO:0007599 125 81 2,000 0,02341942 0,10666269 ! regulation of muscle development GO:0048634 48 32 1,000 0,02420827 0,11003758 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,02420827 0,10982054 ! meiosis I GO:0007127 52 32 1,000 0,02420827 0,10960436 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02420827 0,10938903 ! regulation of protein stability GO:0031647 48 32 1,000 0,02420827 0,10917454 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02420827 0,10896089 ! vesicle localization GO:0051648 47 32 1,000 0,02420827 0,10874808 ! regulation of cell adhesion GO:0030155 159 83 2,000 0,02494947 0,1118592 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,02564459 0,11475204 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02564459 0,11452922 ! cell junction organization GO:0034330 63 33 1,000 0,02564459 0,11430726 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02564459 0,11408617 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02564459 0,11386592 ! hormone biosynthetic process GO:0042446 45 33 1,000 0,02564459 0,11364653 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,02653227 0,11735428 ! regulation of membrane potential GO:0042391 128 85 2,000 0,02653227 0,11712903 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02711475 0,11947114 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02711475 0,1192427 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02711475 0,11901514 ! female gamete generation GO:0007292 43 34 1,000 0,02711475 0,11878845 ! isoprenoid metabolic process GO:0006720 46 34 1,000 0,02711475 0,11856261 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,02711475 0,11833764 ! embryonic organ development GO:0048568 45 34 1,000 0,02711475 0,11811351 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02816775 0,12246848 GO:0060538|skeletal muscle organ development, ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,02861819 0,12419213 ! cyclic nucleotide metabolic process GO:0009187 58 35 1,000 0,02861819 0,12395825 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02861819 0,12372524 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02861819 0,12349311 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of neurogenesis GO:0050767 153 89 2,000 0,02985578 0,12859232 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,03015431 0,12963534 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 1,000 0,03015431 0,12939348 ! negative regulation of binding GO:0051100 58 36 1,000 0,03015431 0,12915252 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,03015431 0,12891246 GO:0046660|female sex differentiation, ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,03071946 0,13108489 ! hormone metabolic process GO:0042445 121 90 2,000 0,03071946 0,13084214 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,03172254 0,13486478 ! learning GO:0007612 67 37 1,000 0,03172254 0,13461595 ! cell fate commitment GO:0045165 141 92 2,000 0,03248602 0,13760193 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03332233 0,14088484 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,03338885 0,14090708 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,03495311 0,14723836 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,03495311 0,14696919 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03495311 0,146701 ! developmental growth GO:0048589 62 39 1,000 0,03495311 0,14643378 ! synapse organization GO:0050808 55 39 1,000 0,03495311 0,14616754 ! regulation of binding GO:0051098 151 95 2,000 0,03523348 0,1470726 ! in utero embryonic development GO:0001701 147 96 2,000 0,03617521 0,15073005 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,03617521 0,15045748 ! response to calcium ion GO:0051592 58 40 1,000 0,03661433 0,15200894 ! regulation of tube size GO:0035150 60 40 1,000 0,03661433 0,15173505 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03661433 0,15146215 ! T cell differentiation GO:0030217 65 40 1,000 0,03661433 0,15119022 ! double-strand break repair GO:0006302 67 40 1,000 0,03661433 0,15091927 ! B cell differentiation GO:0030183 62 40 1,000 0,03661433 0,15064929 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,03661433 0,15038028 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03719148 0,15247843 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03719148 0,15220712 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03719148 0,15193676 ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03719148 0,15166737 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03719148 0,15139894 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03719148 0,15113145 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03719148 0,1508649 ! sleep GO:0030431 11 5 0,000 0,03719148 0,15059929 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03719148 0,15033462 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03719148 0,15007087 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03719148 0,14980805 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03719148 0,14954615 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03719148 0,14928516 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03719148 0,14902508 ! tongue development GO:0043586 6 5 0,000 0,03719148 0,14876591 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03719148 0,14850764 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03719148 0,14825026 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03719148 0,14799377 ! cobalt ion transport GO:0006824 9 5 0,000 0,03719148 0,14773817 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03719148 0,14748345 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03719148 0,1472296 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03719148 0,14697663 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03719148 0,14672453 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03719148 0,14647329 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03719148 0,1462229 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03719148 0,14597338 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03719148 0,1457247 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03719148 0,14547687 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03719148 0,14522988 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03719148 0,14498373 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03719148 0,14473841 ! malate metabolic process GO:0006108 7 5 0,000 0,03719148 0,14449392 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03719148 0,14425025 ! behavioral response to pain GO:0048266 7 5 0,000 0,03719148 0,14400741 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03719148 0,14376538 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03719148 0,14352416 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03719148 0,14328375 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03719148 0,14304414 ! mating behavior GO:0007617 6 5 0,000 0,03719148 0,14280534 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03719148 0,14256733 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03719148 0,14233011 ! rhythmic behavior GO:0007622 12 5 0,000 0,03719148 0,14209369 ! copulation GO:0007620 7 5 0,000 0,03719148 0,14185804 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03719148 0,14162318 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03719148 0,14138909 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03719148 0,14115577 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03719148 0,14092323 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03719148 0,14069145 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03719148 0,14046042 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03719148 0,14023016 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03719148 0,14000065 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03719148 0,13977189 ! response to protozoan GO:0001562 9 5 0,000 0,03719148 0,13954388 ! lymph vessel development GO:0001945 7 5 0,000 0,03719148 0,13931661 ! endochondral ossification GO:0001958 12 5 0,000 0,03719148 0,13909008 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03719148 0,13886428 ! parathyroid gland development GO:0060017 8 5 0,000 0,03719148 0,13863922 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03719148 0,13841488 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03719148 0,13819127 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03719148 0,13796838 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03719148 0,13774621 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03719148 0,13752476 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03719148 0,13730401 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03719148 0,13708397 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03719148 0,13686464 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03719148 0,136646 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03719148 0,13642807 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03719148 0,13621083 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03719148 0,13599427 ! ovulation GO:0030728 6 5 0,000 0,03719148 0,13577841 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03719148 0,13556323 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 9 5 0,000 0,03719148 0,13534873 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03719148 0,13513491 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03719148 0,13492176 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03719148 0,13470929 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03719148 0,13449748 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03719148 0,13428634 ! polyol catabolic process GO:0046174 7 5 0,000 0,03719148 0,13407586 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03719148 0,13386604 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03719148 0,13365687 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03719148 0,13344836 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03719148 0,1332405 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03719148 0,13303328 ! urea metabolic process GO:0019627 6 5 0,000 0,03719148 0,13282671 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03719148 0,13262077 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03719148 0,13241548 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03719148 0,13221082 ! neutrophil activation GO:0042119 5 5 0,000 0,03719148 0,13200679 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03719148 0,13180339 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03719148 0,13160061 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03719148 0,13139846 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03719148 0,13119693 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03719148 0,13099602 ! forebrain neuron development GO:0021884 7 5 0,000 0,03719148 0,13079572 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03719148 0,13059603 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03719148 0,13039695 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03719148 0,13019848 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03719148 0,13000061 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03719148 0,12980334 ! nucleoside transport GO:0015858 6 5 0,000 0,03719148 0,12960666 ! nucleoside salvage GO:0043174 7 5 0,000 0,03719148 0,12941059 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03719148 0,1292151 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03719148 0,12902021 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03719148 0,1288259 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03719148 0,12863218 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03719148 0,12843904 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03719148 0,12824647 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03719148 0,12805449 ! depyrimidination GO:0045008 8 5 0,000 0,03719148 0,12786308 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03719148 0,12767224 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03719148 0,12748197 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03719148 0,12729226 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03719148 0,12710312 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03719148 0,12691454 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03719148 0,12672652 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03719148 0,12653905 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03719148 0,12635214 ! monocyte differentiation GO:0030224 8 5 0,000 0,03719148 0,12616578 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03719148 0,12597997 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03719148 0,1257947 ! centrosome duplication GO:0051298 5 5 0,000 0,03719148 0,12560998 ! response to UV-C GO:0010225 6 5 0,000 0,03719148 0,1254258 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03719148 0,12524216 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03719148 0,12505906 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03719148 0,12487649 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03719148 0,12469446 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03719148 0,12451295 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03719148 0,12433197 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03719148 0,12415152 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03719148 0,12397159 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03719148 0,12379218 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03719148 0,12361329 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03719148 0,12343492 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03719148 0,12325706 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03719148 0,12307971 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03719148 0,12290287 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03719148 0,12272654 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03719148 0,12255071 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03719148 0,12237539 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03719148 0,12220057 ! neural tube patterning GO:0021532 6 5 0,000 0,03719148 0,12202625 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03719148 0,12185242 ! histone demethylation GO:0016577 9 5 0,000 0,03719148 0,12167909 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03719148 0,12150625 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03719148 0,1213339 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03719148 0,12116204 ! enteric nervous system development GO:0048484 8 5 0,000 0,03719148 0,12099066 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03719148 0,12081977 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03719148 0,12064936 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03719148 0,12047943 ! transcription termination GO:0006353 8 5 0,000 0,03719148 0,12030998 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03719148 0,12014101 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03719148 0,11997251 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03719148 0,11980448 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03719148 0,11963692 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03719148 0,11946983 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03719148 0,11930321 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03719148 0,11913705 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03719148 0,11897135 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03719148 0,11880611 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03719148 0,11864133 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03719148 0,11847701 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03719148 0,11831314 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03719148 0,11814972 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03719148 0,11798676 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03719148 0,11782424 ! glial cell migration GO:0008347 10 5 0,000 0,03719148 0,11766217 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03719148 0,11750055 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03719148 0,11733937 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03719148 0,11717863 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03719148 0,11701833 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03719148 0,11685847 ! neural plate development GO:0001840 6 5 0,000 0,03719148 0,11669904 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03719148 0,11654005 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03719148 0,11638149 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03719148 0,11622337 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03719148 0,11606567 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03719148 0,1159084 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03719148 0,11575155 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03719148 0,11559513 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03719148 0,11543913 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03719148 0,11528356 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03719148 0,1151284 ! spindle assembly GO:0051225 5 5 0,000 0,03719148 0,11497365 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03719148 0,11481933 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03719148 0,11466541 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03719148 0,11451191 ! organ regeneration GO:0031100 7 5 0,000 0,03719148 0,11435882 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03719148 0,11420614 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03719148 0,11405386 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03719148 0,113902 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03719148 0,11375053 GO:0055081|anion homeostasis, ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03830544 0,11700202 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,03830544 0,11684685 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,03830544 0,11669208 ! protein import GO:0017038 156 99 2,000 0,03907767 0,11888709 ! mitochondrial transport GO:0006839 60 42 1,000 0,04002592 0,12161112 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,04002592 0,12145068 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,04002592 0,12129067 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,04002592 0,12113107 ! excretion GO:0007588 63 42 1,000 0,04002592 0,1209719 ! regulation of cell shape GO:0008360 78 42 1,000 0,04002592 0,12081314 ! regulation of translation GO:0006417 151 100 2,000 0,04007078 0,12079004 ! protein localization in organelle GO:0033365 161 100 2,000 0,04007078 0,12063194 ! positive regulation of binding GO:0051099 59 43 1,000 0,04177522 0,1255987 ! leukocyte migration GO:0050900 60 43 1,000 0,04177522 0,12543473 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04177522 0,12527119 ! vesicle organization GO:0016050 79 43 1,000 0,04177522 0,12510808 ! regulation of action potential GO:0001508 71 44 1,000 0,04355282 0,13026201 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,04355282 0,13009284 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,04355282 0,1299241 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,04355282 0,12975581 ! ribonucleoprotein complex assembly GO:0022618 70 44 1,000 0,04355282 0,12958795 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04355282 0,12942052 ! tRNA transcription GO:0009304 11 6 0,000 0,04446336 0,13195578 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04446336 0,13178574 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04446336 0,13161613 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04446336 0,13144696 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04446336 0,13127822 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04446336 0,13110991 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04446336 0,13094204 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04446336 0,13077459 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04446336 0,13060758 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04446336 0,13044099 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04446336 0,13027482 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04446336 0,13010908 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04446336 0,12994375 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04446336 0,12977885 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04446336 0,12961436 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04446336 0,12945029 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04446336 0,12928664 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04446336 0,1291234 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04446336 0,12896057 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,04446336 0,12879815 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04446336 0,12863614 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04446336 0,12847454 ! signal peptide processing GO:0006465 8 6 0,000 0,04446336 0,12831334 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04446336 0,12815255 ! mRNA stabilization GO:0048255 15 6 0,000 0,04446336 0,12799216 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04446336 0,12783217 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04446336 0,12767258 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04446336 0,12751338 ! opsonization GO:0008228 8 6 0,000 0,04446336 0,12735459 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04446336 0,12719619 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04446336 0,12703818 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04446336 0,12688056 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04446336 0,12672334 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04446336 0,1265665 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04446336 0,12641005 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04446336 0,12625399 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04446336 0,12609831 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04446336 0,12594302 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04446336 0,12578811 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04446336 0,12563358 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04446336 0,12547943 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04446336 0,12532565 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04446336 0,12517226 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04446336 0,12501923 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04446336 0,12486658 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04446336 0,12471431 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04446336 0,1245624 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04446336 0,12441087 ! thymic T cell selection GO:0045061 12 6 0,000 0,04446336 0,1242597 ! protein lipoylation GO:0009249 10 6 0,000 0,04446336 0,1241089 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04446336 0,12395846 ! drug transport GO:0015893 6 6 0,000 0,04446336 0,12380839 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04446336 0,12365869 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04446336 0,12350934 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04446336 0,12336035 ! histidine metabolic process GO:0006547 6 6 0,000 0,04446336 0,12321173 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04446336 0,12306346 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04446336 0,12291554 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04446336 0,12276799 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04446336 0,12262078 ! adenohypophysis development GO:0021984 10 6 0,000 0,04446336 0,12247393 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04446336 0,12232743 ! hyperosmotic response GO:0006972 8 6 0,000 0,04446336 0,12218128 ! microtubule nucleation GO:0007020 10 6 0,000 0,04446336 0,12203548 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04446336 0,12189003 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04446336 0,12174492 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04446336 0,12160016 ! response to dietary excess GO:0002021 7 6 0,000 0,04446336 0,12145574 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04446336 0,12131166 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04446336 0,12116793 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04446336 0,12102454 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04446336 0,12088148 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04446336 0,12073876 ! organic alcohol transport GO:0015850 9 6 0,000 0,04446336 0,12059638 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04446336 0,12045434 ! carnitine transport GO:0015879 8 6 0,000 0,04446336 0,12031263 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04446336 0,12017125 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04446336 0,1200302 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04446336 0,11988949 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04446336 0,1197491 ! parturition GO:0007567 12 6 0,000 0,04446336 0,11960904 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04446336 0,11946931 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04446336 0,11932991 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04446336 0,11919083 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04446336 0,11905208 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04446336 0,11891364 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04446336 0,11877553 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04446336 0,11863774 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04446336 0,11850027 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04446336 0,11836312 ! macrophage differentiation GO:0030225 10 6 0,000 0,04446336 0,11822628 ! astrocyte development GO:0014002 14 6 0,000 0,04446336 0,11808976 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04446336 0,11795356 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04446336 0,11781766 ! interaction with symbiont GO:0051702 8 6 0,000 0,04446336 0,11768209 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04446336 0,11754682 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04446336 0,11741186 ! eating behavior GO:0042755 6 6 0,000 0,04446336 0,11727722 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04446336 0,11714288 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04446336 0,11700885 ! response to copper ion GO:0046688 9 6 0,000 0,04446336 0,11687512 ! DNA topological change GO:0006265 8 6 0,000 0,04446336 0,1167417 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04446336 0,11660859 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04446336 0,11647578 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04446336 0,11634327 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04446336 0,11621106 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04446336 0,11607915 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04446336 0,11594754 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04446336 0,11581623 ! gas homeostasis GO:0033483 11 6 0,000 0,04446336 0,11568522 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04446336 0,1155545 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04446336 0,11542408 ! Schwann cell development GO:0014044 14 6 0,000 0,04446336 0,11529395 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04446336 0,11516411 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04446336 0,11503457 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04446336 0,11490532 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04446336 0,11477636 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04446336 0,11464768 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04446336 0,1145193 ! histone ubiquitination GO:0016574 7 6 0,000 0,04446336 0,1143912 ! regulation of meiosis GO:0040020 10 6 0,000 0,04446336 0,11426339 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04446336 0,11413586 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04446336 0,11400862 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04446336 0,11388166 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04446336 0,11375499 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04446336 0,11362859 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04446336 0,11350248 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04446336 0,11337664 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04446336 0,11325109 ! receptor internalization GO:0031623 9 6 0,000 0,04446336 0,11312581 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04446336 0,11300081 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04446336 0,11287608 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04446336 0,11275164 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04446336 0,11262746 ! protein deubiquitination GO:0016579 8 6 0,000 0,04446336 0,11250356 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04446336 0,11237993 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04446336 0,11225657 ! axonal fasciculation GO:0007413 9 6 0,000 0,04446336 0,11213348 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04446336 0,11201066 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04446336 0,11188811 ! midbrain development GO:0030901 6 6 0,000 0,04446336 0,11176583 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04446336 0,11164381 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04446336 0,11152206 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04446336 0,11140058 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04446336 0,11127936 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04446336 0,11115841 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04446336 0,11103771 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04446336 0,11091728 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04446336 0,11079711 ! adult feeding behavior GO:0008343 6 6 0,000 0,04446336 0,1106772 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04446336 0,11055755 ! blastocyst growth GO:0001832 15 6 0,000 0,04446336 0,11043816 ! pigment granule transport GO:0051904 12 6 0,000 0,04446336 0,11031902 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04446336 0,11020014 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04446336 0,11008152 ! catecholamine transport GO:0051937 7 6 0,000 0,04446336 0,10996315 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04446336 0,10984504 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04446336 0,10972718 ! protein prenylation GO:0018342 10 6 0,000 0,04446336 0,10960957 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04446336 0,10949222 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04446336 0,10937512 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04446336 0,10925826 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04446336 0,10914166 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04446336 0,1090253 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,0453582 0,11110102 ! cell maturation GO:0048469 60 45 1,000 0,0453582 0,11098282 ! histone modification GO:0016570 68 46 1,000 0,04719084 0,11534425 ! covalent chromatin modification GO:0016569 75 47 1,000 0,04905024 0,11976174 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,04905024 0,11963474 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,04905024 0,11950801 ! regulation of muscle contraction GO:0006937 69 48 1,000 0,0509359 0,12397098 ! response to temperature stimulus GO:0009266 62 48 1,000 0,0509359 0,12383993 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,0509359 0,12370916 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,0509359 0,12357867 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,0509359 0,12344845 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05168074 0,12512178 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05168074 0,12499021 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05168074 0,12485892 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05168074 0,12472791 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05168074 0,12459716 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05168074 0,1244667 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05168074 0,1243365 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05168074 0,12420658 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05168074 0,12407693 ! reproductive behavior GO:0019098 12 7 0,000 0,05168074 0,12394754 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05168074 0,12381843 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,05168074 0,12368959 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05168074 0,12356101 ! oligopeptide transport GO:0006857 11 7 0,000 0,05168074 0,1234327 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05168074 0,12330466 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05168074 0,12317689 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05168074 0,12304937 ! RNA methylation GO:0001510 11 7 0,000 0,05168074 0,12292212 ! pericardium development GO:0060039 8 7 0,000 0,05168074 0,12279514 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05168074 0,12266842 ! fibril organization GO:0043206 13 7 0,000 0,05168074 0,12254195 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05168074 0,12241575 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05168074 0,12228981 ! lipoprotein transport GO:0042953 9 7 0,000 0,05168074 0,12216413 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05168074 0,1220387 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05168074 0,12191353 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05168074 0,12178862 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05168074 0,12166397 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05168074 0,12153956 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05168074 0,12141542 ! chemosensory behavior GO:0007635 9 7 0,000 0,05168074 0,12129152 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05168074 0,12116788 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05168074 0,1210445 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05168074 0,12092136 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05168074 0,12079847 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05168074 0,12067583 ! reflex GO:0060004 12 7 0,000 0,05168074 0,12055344 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05168074 0,1204313 GO:0045911|positive regulation of DNA recombination, ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05168074 0,12030941 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05168074 0,12018776 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05168074 0,12006636 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05168074 0,1199452 ! spinal cord patterning GO:0021511 7 7 0,000 0,05168074 0,11982429 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05168074 0,11970362 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05168074 0,11958319 ! adrenal gland development GO:0030325 17 7 0,000 0,05168074 0,11946301 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05168074 0,11934307 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05168074 0,11922336 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05168074 0,1191039 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05168074 0,11898468 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05168074 0,11886569 ! endosome organization GO:0007032 10 7 0,000 0,05168074 0,11874695 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05168074 0,11862844 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05168074 0,11851016 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,05168074 0,11839213 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05168074 0,11827432 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05168074 0,11815675 ! galactose metabolic process GO:0006012 10 7 0,000 0,05168074 0,11803942 ! vesicle fusion GO:0006906 15 7 0,000 0,05168074 0,11792232 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05168074 0,11780545 GO:0045851|pH reduction, ! organ growth GO:0035265 11 7 0,000 0,05168074 0,11768881 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05168074 0,1175724 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05168074 0,11745622 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05168074 0,11734027 ! behavioral fear response GO:0001662 13 7 0,000 0,05168074 0,11722455 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05168074 0,11710906 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05168074 0,11699379 ! rRNA modification GO:0000154 12 7 0,000 0,05168074 0,11687876 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05168074 0,11676394 ! response to UV-B GO:0010224 11 7 0,000 0,05168074 0,11664936 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05168074 0,11653499 ! intermediate filament organization GO:0045109 11 7 0,000 0,05168074 0,11642086 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05168074 0,11630694 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05168074 0,11619325 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,05168074 0,11607978 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05168074 0,11596653 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05168074 0,1158535 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05168074 0,1157407 ! response to tropane GO:0014073 13 7 0,000 0,05168074 0,11562811 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05168074 0,11551574 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05168074 0,11540359 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05168074 0,11529165 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05168074 0,11517994 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05168074 0,11506844 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05168074 0,11495715 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05168074 0,11484608 ! mast cell activation GO:0045576 9 7 0,000 0,05168074 0,11473523 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05168074 0,11462458 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05168074 0,11451416 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05168074 0,11440394 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05168074 0,11429394 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05168074 0,11418414 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05168074 0,11407456 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05168074 0,11396519 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05168074 0,11385603 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05168074 0,11374708 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05168074 0,11363833 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05168074 0,11352979 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05168074 0,11342146 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05168074 0,11331334 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,05168074 0,11320542 ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05168074 0,11309771 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05168074 0,1129902 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05168074 0,1128829 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05168074 0,1127758 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05168074 0,1126689 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05168074 0,11256221 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05168074 0,11245572 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05168074 0,11234943 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05168074 0,11224334 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05168074 0,11213745 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,05168074 0,11203176 ! lymph node development GO:0048535 9 7 0,000 0,05168074 0,11192627 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05168074 0,11182097 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05168074 0,11171588 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05168074 0,11161098 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05168074 0,11150628 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05168074 0,11140178 ! ATP catabolic process GO:0006200 10 7 0,000 0,05168074 0,11129747 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05168074 0,11119335 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05168074 0,11108943 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05168074 0,11098571 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05168074 0,11088218 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05168074 0,11077884 ! muscle adaptation GO:0043500 12 7 0,000 0,05168074 0,11067569 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05168074 0,11057274 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05168074 0,11046998 ! retina homeostasis GO:0001895 9 7 0,000 0,05168074 0,1103674 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05168074 0,11026502 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05168074 0,11016283 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05168074 0,11006083 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05168074 0,10995901 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05168074 0,10985739 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05168074 0,10975595 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 1,000 0,05284732 0,11212993 ! RNA elongation GO:0006354 62 49 1,000 0,05284732 0,11202658 ! regulation of actin filament length GO:0030832 72 50 1,000 0,05478401 0,11602507 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05478401 0,11591833 ! lipid modification GO:0030258 73 50 1,000 0,05478401 0,11581179 ! muscle fiber development GO:0048747 74 51 1,000 0,05674549 0,11984814 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,05674549 0,11973818 ! transition metal ion transport GO:0000041 74 52 1,000 0,05873127 0,12381478 ! regulation of cellular component size GO:0032535 74 52 1,000 0,05873127 0,1237014 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,05873127 0,12358822 ! establishment of organelle localization GO:0051656 85 52 1,000 0,05873127 0,12347525 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05884401 0,12359928 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05884401 0,12348651 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05884401 0,12337394 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05884401 0,12326158 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05884401 0,12314942 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05884401 0,12303747 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05884401 0,12292572 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05884401 0,12281417 ! phosphate transport GO:0006817 10 8 0,000 0,05884401 0,12270282 ! N-glycan processing GO:0006491 12 8 0,000 0,05884401 0,12259168 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05884401 0,12248074 ! UTP metabolic process GO:0046051 8 8 0,000 0,05884401 0,12237 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05884401 0,12225945 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05884401 0,12214911 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,05884401 0,12203897 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05884401 0,12192902 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05884401 0,12181928 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05884401 0,12170973 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05884401 0,12160037 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05884401 0,12149122 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05884401 0,12138226 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05884401 0,12127349 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05884401 0,12116492 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05884401 0,12105654 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05884401 0,12094836 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05884401 0,12084037 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05884401 0,12073257 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05884401 0,12062497 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05884401 0,12051756 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05884401 0,12041033 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05884401 0,1203033 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05884401 0,12019646 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05884401 0,12008981 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05884401 0,11998335 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05884401 0,11987707 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05884401 0,11977099 ! melanin metabolic process GO:0006582 12 8 0,000 0,05884401 0,11966509 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05884401 0,11955938 ! macrophage activation GO:0042116 12 8 0,000 0,05884401 0,11945385 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05884401 0,11934851 ! multicellular organism growth GO:0035264 14 8 0,000 0,05884401 0,11924336 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05884401 0,11913839 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05884401 0,11903361 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05884401 0,11892901 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05884401 0,1188246 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05884401 0,11872036 ! ruffle organization GO:0031529 11 8 0,000 0,05884401 0,11861631 ! osteoblast development GO:0002076 13 8 0,000 0,05884401 0,11851245 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05884401 0,11840876 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05884401 0,11830526 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05884401 0,11820193 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05884401 0,11809879 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05884401 0,11799583 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05884401 0,11789304 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05884401 0,11779044 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05884401 0,11768801 ! brain morphogenesis GO:0048854 20 8 0,000 0,05884401 0,11758576 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05884401 0,11748369 ! segment specification GO:0007379 10 8 0,000 0,05884401 0,1173818 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05884401 0,11728008 ! cellular extravasation GO:0045123 11 8 0,000 0,05884401 0,11717854 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05884401 0,11707718 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05884401 0,11697599 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05884401 0,11687497 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05884401 0,11677413 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05884401 0,11667346 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05884401 0,11657297 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05884401 0,11647265 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05884401 0,1163725 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05884401 0,11627252 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05884401 0,11617272 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05884401 0,11607308 ! icosanoid secretion GO:0032309 12 8 0,000 0,05884401 0,11597362 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05884401 0,11587433 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05884401 0,11577521 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05884401 0,11567625 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05884401 0,11557747 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05884401 0,11547885 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05884401 0,11538041 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05884401 0,11528213 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05884401 0,11518401 ! sterol catabolic process GO:0016127 9 8 0,000 0,05884401 0,11508607 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05884401 0,11498829 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05884401 0,11489068 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05884401 0,11479323 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05884401 0,11469595 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05884401 0,11459883 ! prophase GO:0051324 11 8 0,000 0,05884401 0,11450187 ! S phase GO:0051320 8 8 0,000 0,05884401 0,11440508 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05884401 0,11430846 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05884401 0,114212 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05884401 0,1141157 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05884401 0,11401956 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05884401 0,11392358 ! hormone catabolic process GO:0042447 13 8 0,000 0,05884401 0,11382777 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05884401 0,11373211 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05884401 0,11363662 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05884401 0,11354129 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05884401 0,11344611 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05884401 0,1133511 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05884401 0,11325625 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05884401 0,11316155 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05884401 0,11306701 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05884401 0,11297263 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05884401 0,11287841 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05884401 0,11278435 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05884401 0,11269044 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05884401 0,11259668 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05884401 0,11250309 ! cell projection assembly GO:0030031 76 53 1,000 0,06074089 0,11603326 ! detection of external stimulus GO:0009581 66 54 1,000 0,06277388 0,11981737 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06595357 0,12578211 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06595357 0,1256779 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06595357 0,12557386 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06595357 0,12546999 ! CTP metabolic process GO:0046036 9 9 0,000 0,06595357 0,1253663 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06595357 0,12526278 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06595357 0,12515942 ! GTP metabolic process GO:0046039 9 9 0,000 0,06595357 0,12505624 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06595357 0,12495323 ! social behavior GO:0035176 14 9 0,000 0,06595357 0,12485039 ! artery development GO:0060840 19 9 0,000 0,06595357 0,12474772 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06595357 0,12464521 ! response to pain GO:0048265 16 9 0,000 0,06595357 0,12454287 ! protein complex disassembly GO:0043241 17 9 0,000 0,06595357 0,12444071 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06595357 0,12433871 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06595357 0,12423687 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06595357 0,12413521 ! lung alveolus development GO:0048286 17 9 0,000 0,06595357 0,12403371 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06595357 0,12393237 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06595357 0,1238312 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06595357 0,1237302 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06595357 0,12362936 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06595357 0,12352868 ! protein targeting to ER GO:0045047 19 9 0,000 0,06595357 0,12342817 ! T cell selection GO:0045058 18 9 0,000 0,06595357 0,12332782 ! endoderm development GO:0007492 12 9 0,000 0,06595357 0,12322764 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06595357 0,12312761 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06595357 0,12302775 ! arginine catabolic process GO:0006527 10 9 0,000 0,06595357 0,12292806 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06595357 0,12282852 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06595357 0,12272914 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06595357 0,12262993 ! V(D)J recombination GO:0033151 12 9 0,000 0,06595357 0,12253087 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06595357 0,12243198 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06595357 0,12233324 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06595357 0,12223467 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06595357 0,12213625 ! mannose metabolic process GO:0006013 9 9 0,000 0,06595357 0,12203799 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06595357 0,12193989 ! receptor clustering GO:0043113 15 9 0,000 0,06595357 0,12184195 ! epithelial cell development GO:0002064 10 9 0,000 0,06595357 0,12174416 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06595357 0,12164653 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06595357 0,12154906 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06595357 0,12145174 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06595357 0,12135458 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06595357 0,12125757 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06595357 0,12116072 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06595357 0,12106402 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06595357 0,12096748 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06595357 0,12087109 ! DNA ligation GO:0006266 14 9 0,000 0,06595357 0,12077486 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06595357 0,12067878 ! response to amine stimulus GO:0014075 13 9 0,000 0,06595357 0,12058285 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06595357 0,12048707 ! erythrocyte development GO:0048821 11 9 0,000 0,06595357 0,12039145 ! postreplication repair GO:0006301 11 9 0,000 0,06595357 0,12029597 ! mRNA cleavage GO:0006379 13 9 0,000 0,06595357 0,12020065 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06595357 0,12010548 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06595357 0,12001046 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06595357 0,11991559 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06595357 0,11982087 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06595357 0,1197263 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06595357 0,11963188 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06595357 0,11953761 ! acid secretion GO:0046717 14 9 0,000 0,06595357 0,11944348 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06595357 0,11934951 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06595357 0,11925568 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06595357 0,119162 ! purine base metabolic process GO:0006144 18 9 0,000 0,06595357 0,11906846 ! thymus development GO:0048538 15 9 0,000 0,06595357 0,11897508 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06595357 0,11888184 ! spleen development GO:0048536 15 9 0,000 0,06595357 0,11878874 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06595357 0,11869579 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06595357 0,11860299 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06595357 0,11851033 ! detection of calcium ion GO:0005513 13 9 0,000 0,06595357 0,11841782 ! blastocyst formation GO:0001825 12 9 0,000 0,06595357 0,11832545 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06595357 0,11823322 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06595357 0,11814114 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06595357 0,1180492 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06595357 0,1179574 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06595357 0,11786575 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06595357 0,11777424 ! prepulse inhibition GO:0060134 14 9 0,000 0,06595357 0,11768287 ! embryonic placenta development GO:0001892 12 9 0,000 0,06595357 0,11759164 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06595357 0,11750056 ! insulin secretion GO:0030073 17 9 0,000 0,06595357 0,11740961 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06595357 0,11731881 ! response to nicotine GO:0035094 16 9 0,000 0,06595357 0,11722815 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06595357 0,11713762 ! nucleus localization GO:0051647 15 9 0,000 0,06595357 0,11704724 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06595357 0,11695699 ! secondary metabolic process GO:0019748 84 57 1,000 0,06900848 0,12228004 ! viral reproductive process GO:0022415 87 58 1,000 0,07113038 0,12594294 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07300984 0,12917126 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07300984 0,12907197 ! neuron fate specification GO:0048665 11 10 0,000 0,07300984 0,12897284 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07300984 0,12887385 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07300984 0,12877502 ! thyroid gland development GO:0030878 19 10 0,000 0,07300984 0,12867635 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07300984 0,12857782 ! synapsis GO:0007129 13 10 0,000 0,07300984 0,12847944 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07300984 0,12838122 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07300984 0,12828314 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07300984 0,12818522 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07300984 0,12808744 ! sulfate transport GO:0008272 12 10 0,000 0,07300984 0,12798981 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07300984 0,12789233 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07300984 0,127795 ! androgen metabolic process GO:0008209 13 10 0,000 0,07300984 0,12769782 ! phospholipid efflux GO:0033700 16 10 0,000 0,07300984 0,12760078 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,07300984 0,1275039 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07300984 0,12740716 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07300984 0,12731056 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07300984 0,12721412 ! pathogenesis GO:0009405 13 10 0,000 0,07300984 0,12711781 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07300984 0,12702166 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07300984 0,12692565 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07300984 0,12682978 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07300984 0,12673406 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,07300984 0,12663849 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07300984 0,12654305 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07300984 0,12644777 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07300984 0,12635262 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07300984 0,12625762 ! B cell proliferation GO:0042100 14 10 0,000 0,07300984 0,12616276 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07300984 0,12606804 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07300984 0,12597347 ! forebrain cell migration GO:0021885 17 10 0,000 0,07300984 0,12587903 ! lipid digestion GO:0044241 15 10 0,000 0,07300984 0,12578474 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07300984 0,12569059 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07300984 0,12559658 ! UV protection GO:0009650 14 10 0,000 0,07300984 0,12550271 ! entry into host cell GO:0030260 20 10 0,000 0,07300984 0,12540899 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07300984 0,1253154 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07300984 0,12522195 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07300984 0,12512864 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07300984 0,12503547 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07300984 0,12494243 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07300984 0,12484954 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07300984 0,12475678 ! regulation of organ growth GO:0046620 11 10 0,000 0,07300984 0,12466417 ! response to dsRNA GO:0043331 18 10 0,000 0,07300984 0,12457169 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07300984 0,12447934 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07300984 0,12438714 ! embryonic axis specification GO:0000578 12 10 0,000 0,07300984 0,12429506 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07300984 0,12420313 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07300984 0,12411133 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07300984 0,12401967 ! cranial nerve development GO:0021545 12 10 0,000 0,07300984 0,12392814 ! fucose catabolic process GO:0019317 16 10 0,000 0,07300984 0,12383675 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07300984 0,12374549 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07300984 0,12365437 ! protein sumoylation GO:0016925 12 10 0,000 0,07300984 0,12356338 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07300984 0,12347252 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07300984 0,1233818 ! zymogen activation GO:0031638 14 10 0,000 0,07300984 0,12329121 ! salivary gland development GO:0007431 22 10 0,000 0,07300984 0,12320076 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07300984 0,12311043 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07300984 0,12302024 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07300984 0,12293018 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07300984 0,12284026 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07300984 0,12275046 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07300984 0,1226608 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07300984 0,12257126 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07300984 0,12248186 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07300984 0,12239259 ! detection of bacterium GO:0016045 10 10 0,000 0,07300984 0,12230345 ! embryonic gut development GO:0048566 11 10 0,000 0,07300984 0,12221443 ! activation of innate immune response GO:0002218 10 10 0,000 0,07300984 0,12212555 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07300984 0,1220368 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07300984 0,12194817 ! developmental induction GO:0031128 13 10 0,000 0,07300984 0,12185968 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07300984 0,12177131 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07300984 0,12168307 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07300984 0,12159495 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07300984 0,12150697 ! actin filament organization GO:0007015 95 59 1,000 0,07327341 0,12185743 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,07327341 0,12176939 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,07543711 0,12527463 ! regulation of heart contraction GO:0008016 91 60 1,000 0,07543711 0,12518424 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,07543711 0,12509399 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,07762107 0,12862282 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,07762107 0,12853021 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,07982486 0,13208431 ! organelle localization GO:0051640 96 62 1,000 0,07982486 0,13198935 ! rRNA transcription GO:0009303 17 11 0,000 0,0800132 0,13220572 ! respiratory burst GO:0045730 14 11 0,000 0,0800132 0,13211081 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,0800132 0,13201604 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,0800132 0,1319214 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,0800132 0,13182691 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,0800132 0,13173254 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,0800132 0,13163831 ! RNA polyadenylation GO:0043631 19 11 0,000 0,0800132 0,13154422 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,0800132 0,13145026 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,0800132 0,13135643 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,0800132 0,13126274 ! T cell proliferation GO:0042098 20 11 0,000 0,0800132 0,13116918 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,0800132 0,13107575 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,0800132 0,13098246 ! bone resorption GO:0045453 16 11 0,000 0,0800132 0,1308893 ! regulated secretory pathway GO:0045055 14 11 0,000 0,0800132 0,13079628 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,0800132 0,13070338 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,0800132 0,13061062 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,0800132 0,13051799 ! syncytium formation GO:0006949 15 11 0,000 0,0800132 0,13042549 ! plasma membrane organization GO:0007009 18 11 0,000 0,0800132 0,13033312 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,0800132 0,13024088 ! focal adhesion formation GO:0048041 24 11 0,000 0,0800132 0,13014877 ! mitotic spindle organization GO:0007052 15 11 0,000 0,0800132 0,13005679 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,0800132 0,12996494 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,0800132 0,12987322 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,0800132 0,12978164 ! adult heart development GO:0007512 11 11 0,000 0,0800132 0,12969018 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,0800132 0,12959884 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,0800132 0,12950764 ! temperature homeostasis GO:0001659 16 11 0,000 0,0800132 0,12941657 ! L-glutamate transport GO:0015813 16 11 0,000 0,0800132 0,12932562 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,0800132 0,1292348 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,0800132 0,12914411 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,0800132 0,12905355 ! stem cell development GO:0048864 29 11 0,000 0,0800132 0,12896311 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,0800132 0,1288728 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,0800132 0,12878262 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,0800132 0,12869256 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,0800132 0,12860263 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,0800132 0,12851282 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,0800132 0,12842314 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,0800132 0,12833358 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,0800132 0,12824415 ! ribosome assembly GO:0042255 13 11 0,000 0,0800132 0,12815485 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,0800132 0,12806566 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,0800132 0,12797661 ! chromatin silencing GO:0006342 19 11 0,000 0,0800132 0,12788767 ! nucleosome positioning GO:0016584 13 11 0,000 0,0800132 0,12779886 ! regulation of isotype switching GO:0045191 19 11 0,000 0,0800132 0,12771017 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,0800132 0,12762161 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,0800132 0,12753317 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,0800132 0,12744485 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,0800132 0,12735665 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,0800132 0,12726858 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,0800132 0,12718062 ! oxygen transport GO:0015671 15 11 0,000 0,0800132 0,12709279 ! male genitalia development GO:0030539 13 11 0,000 0,0800132 0,12700508 ! cholesterol efflux GO:0033344 19 11 0,000 0,0800132 0,12691749 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,0800132 0,12683002 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,0800132 0,12674267 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,0800132 0,12665544 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,0800132 0,12656834 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,0800132 0,12648135 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,0800132 0,12639448 ! defense response to fungus GO:0050832 12 11 0,000 0,0800132 0,12630773 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,0800132 0,1262211 ! lysogeny GO:0030069 18 11 0,000 0,0800132 0,12613459 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,0800132 0,12604819 ! acrosome reaction GO:0007340 13 11 0,000 0,0800132 0,12596192 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,0800132 0,12587576 ! viral reproduction GO:0016032 92 63 1,000 0,08204807 0,12898876 ! adaptive immune response GO:0002250 94 64 1,000 0,08429027 0,13242324 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! defense response to bacterium GO:0042742 73 65 1,000 0,08655106 0,13588221 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,08655106 0,13578952 ! lactation GO:0007595 20 12 0,000 0,08696405 0,13634445 ! reproductive cellular process GO:0048610 14 12 0,000 0,08696405 0,13625157 ! tRNA modification GO:0006400 14 12 0,000 0,08696405 0,13615882 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08696405 0,1360662 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08696405 0,1359737 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08696405 0,13588132 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08696405 0,13578908 ! non-recombinational repair GO:0000726 19 12 0,000 0,08696405 0,13569695 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08696405 0,13560496 ! peroxisomal transport GO:0043574 21 12 0,000 0,08696405 0,13551308 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08696405 0,13542133 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08696405 0,13532971 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08696405 0,13523821 ! heart looping GO:0001947 15 12 0,000 0,08696405 0,13514683 ! palate development GO:0060021 15 12 0,000 0,08696405 0,13505558 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08696405 0,13496445 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08696405 0,13487344 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08696405 0,13478255 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08696405 0,13469179 ! arginine metabolic process GO:0006525 13 12 0,000 0,08696405 0,13460115 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08696405 0,13451063 ! methionine metabolic process GO:0006555 13 12 0,000 0,08696405 0,13442023 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08696405 0,13432996 ! Golgi organization GO:0007030 18 12 0,000 0,08696405 0,1342398 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08696405 0,13414977 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08696405 0,13405986 ! monoamine transport GO:0015844 13 12 0,000 0,08696405 0,13397007 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08696405 0,13388039 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08696405 0,13379084 ! L-amino acid transport GO:0015807 20 12 0,000 0,08696405 0,13370141 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08696405 0,1336121 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08696405 0,1335229 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08696405 0,13343383 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08696405 0,13334487 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08696405 0,13325604 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08696405 0,13316732 ! cerebellum development GO:0021549 13 12 0,000 0,08696405 0,13307872 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08696405 0,13299023 ! histone methylation GO:0016571 15 12 0,000 0,08696405 0,13290187 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08696405 0,13281362 ! gland morphogenesis GO:0022612 23 12 0,000 0,08696405 0,13272549 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08696405 0,13263747 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08696405 0,13254958 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08696405 0,13246179 ! intestinal absorption GO:0050892 19 12 0,000 0,08696405 0,13237413 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08696405 0,13228658 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08696405 0,13219915 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08696405 0,13211183 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08696405 0,13202463 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08696405 0,13193754 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08696405 0,13185057 ! microspike assembly GO:0030035 23 12 0,000 0,08696405 0,13176371 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08696405 0,13167696 ! response to cold GO:0009409 14 12 0,000 0,08696405 0,13159033 ! axon guidance GO:0007411 99 66 1,000 0,08883004 0,1343255 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,08883004 0,13423725 ! regulation of immune effector process GO:0002697 101 66 1,000 0,08883004 0,13414911 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,09112681 0,13752733 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,09112681 0,13743715 ! learning or memory GO:0007611 123 68 1,000 0,09344097 0,14083501 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,09344097 0,14074278 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,09344097 0,14065067 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09386277 0,14119318 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09386277 0,1411009 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09386277 0,14100874 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,09386277 0,1409167 ! water transport GO:0006833 17 13 0,000 0,09386277 0,14082477 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09386277 0,14073297 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09386277 0,14064129 ! lipid localization GO:0010876 24 13 0,000 0,09386277 0,14054973 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09386277 0,14045828 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09386277 0,14036696 ! organelle fusion GO:0048284 28 13 0,000 0,09386277 0,14027575 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09386277 0,14018466 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09386277 0,14009369 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09386277 0,14000284 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09386277 0,13991211 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09386277 0,13982149 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,09386277 0,13973099 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09386277 0,13964061 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09386277 0,13955034 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09386277 0,13946019 ! NAD metabolic process GO:0019674 21 13 0,000 0,09386277 0,13937016 ! exocrine system development GO:0035272 27 13 0,000 0,09386277 0,13928024 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09386277 0,13919044 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09386277 0,13910076 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09386277 0,13901119 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09386277 0,13892174 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09386277 0,1388324 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09386277 0,13874317 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,09386277 0,13865407 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,09386277 0,13856507 ! tissue regeneration GO:0042246 21 13 0,000 0,09386277 0,13847619 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09386277 0,13838742 ! cofactor transport GO:0051181 19 13 0,000 0,09386277 0,13829877 ! NADP metabolic process GO:0006739 18 13 0,000 0,09386277 0,13821023 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09386277 0,1381218 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09386277 0,13803349 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09386277 0,13794529 ! gas transport GO:0015669 18 13 0,000 0,09386277 0,1378572 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09386277 0,13776923 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09386277 0,13768136 ! regulation of axon extension GO:0030516 23 13 0,000 0,09386277 0,13759361 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09386277 0,13750597 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09386277 0,13741845 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09386277 0,13733103 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09386277 0,13724372 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09386277 0,13715653 ! response to metal ion GO:0010038 103 70 1,000 0,09811993 0,14328624 ! humoral immune response GO:0006959 86 70 1,000 0,09811993 0,14319532 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,10048396 0,14655238 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,10048396 0,14645951 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,10048396 0,14636675 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,10048396 0,14627412 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,10070977 0,1465101 ! superoxide anion generation GO:0042554 18 14 0,000 0,10070977 0,14641749 ! neuron maturation GO:0042551 21 14 0,000 0,10070977 0,14632499 ! regulation of S phase GO:0033261 18 14 0,000 0,10070977 0,14623262 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,10070977 0,14614035 ! myotube differentiation GO:0014902 21 14 0,000 0,10070977 0,14604821 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,10070977 0,14595618 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,10070977 0,14586427 ! inositol metabolic process GO:0006020 20 14 0,000 0,10070977 0,14577247 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10070977 0,14568079 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,10070977 0,14558923 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,10070977 0,14549778 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10070977 0,14540644 ! response to cAMP GO:0051591 19 14 0,000 0,10070977 0,14531522 ! startle response GO:0001964 21 14 0,000 0,10070977 0,14522411 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,10070977 0,14513312 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10070977 0,14504224 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,10070977 0,14495148 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10070977 0,14486083 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,10070977 0,14477029 ! glycine metabolic process GO:0006544 22 14 0,000 0,10070977 0,14467986 ! pituitary gland development GO:0021983 23 14 0,000 0,10070977 0,14458955 ! lysosomal transport GO:0007041 20 14 0,000 0,10070977 0,14449935 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10070977 0,14440927 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,10070977 0,14431929 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,10070977 0,14422943 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,10070977 0,14413968 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10070977 0,14405004 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,10070977 0,14396051 ! axon cargo transport GO:0008088 27 14 0,000 0,10070977 0,14387109 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,10070977 0,14378179 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,10070977 0,14369259 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,10070977 0,14360351 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,10070977 0,14351454 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10070977 0,14342567 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10070977 0,14333692 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,10070977 0,14324828 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10070977 0,14315974 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10070977 0,14307132 GO:0046466|membrane lipid catabolic process, ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,10070977 0,142983 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,10070977 0,14289479 ! muscle maintenance GO:0046716 19 14 0,000 0,10070977 0,1428067 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,10070977 0,14271871 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,10070977 0,14263083 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10070977 0,14254305 ! cell killing GO:0001906 20 14 0,000 0,10070977 0,14245539 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,10070977 0,14236783 ! cilium assembly GO:0042384 20 14 0,000 0,10070977 0,14228038 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,10286386 0,14523442 ! regulation of blood pressure GO:0008217 107 73 1,000 0,10525926 0,14852534 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10750541 0,15160174 ! metencephalon development GO:0022037 19 15 0,000 0,10750541 0,15150885 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10750541 0,15141607 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,10750541 0,1513234 ! skin development GO:0043588 25 15 0,000 0,10750541 0,15123085 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10750541 0,15113841 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,10750541 0,15104609 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10750541 0,15095387 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10750541 0,15086177 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10750541 0,15076978 ! adult walking behavior GO:0007628 25 15 0,000 0,10750541 0,15067791 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10750541 0,15058614 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10750541 0,15049449 ! myoblast differentiation GO:0045445 27 15 0,000 0,10750541 0,15040295 ! centrosome cycle GO:0007098 16 15 0,000 0,10750541 0,15031152 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10750541 0,1502202 ! cerebral cortex development GO:0021987 29 15 0,000 0,10750541 0,15012899 ! vesicle coating GO:0006901 25 15 0,000 0,10750541 0,15003789 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10750541 0,1499469 ! DNA integration GO:0015074 22 15 0,000 0,10750541 0,14985603 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10750541 0,14976526 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10750541 0,1496746 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10750541 0,14958406 ! neuron recognition GO:0008038 22 15 0,000 0,10750541 0,14949362 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10750541 0,14940329 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,10750541 0,14931307 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10750541 0,14922296 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10750541 0,14913296 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10750541 0,14904306 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10750541 0,14895328 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10750541 0,1488636 ! organic cation transport GO:0015695 19 15 0,000 0,10750541 0,14877403 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10750541 0,14868457 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10750541 0,14859522 ! defense response to virus GO:0051607 27 15 0,000 0,10750541 0,14850597 ! peptide hormone processing GO:0016486 19 15 0,000 0,10750541 0,14841683 ! phospholipid biosynthetic process GO:0008654 102 74 1,000 0,10766979 0,1485546 ! digestion GO:0007586 97 74 1,000 0,10766979 0,14846554 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,10766979 0,14837659 ! response to inorganic substance GO:0010035 115 75 1,000 0,1100951 0,15162798 ! response to nutrient GO:0007584 104 75 1,000 0,1100951 0,15153724 ! regulation of ligase activity GO:0051340 114 75 1,000 0,1100951 0,15144661 ! response to unfolded protein GO:0006986 99 76 1,000 0,11253482 0,15471016 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,11253482 0,15461774 ! protein secretion GO:0009306 27 16 0,000 0,11425009 0,15688072 ! bone remodeling GO:0046849 24 16 0,000 0,11425009 0,15678711 ! endothelial cell migration GO:0043542 22 16 0,000 0,11425009 0,15669362 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11425009 0,15660024 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11425009 0,15650697 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11425009 0,15641381 ! glial cell development GO:0021782 24 16 0,000 0,11425009 0,15632076 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11425009 0,15622783 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11425009 0,156135 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11425009 0,15604228 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11425009 0,15594968 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11425009 0,15585718 ! fructose metabolic process GO:0006000 20 16 0,000 0,11425009 0,15576479 ! regulation of protein binding GO:0043393 27 16 0,000 0,11425009 0,15567251 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11425009 0,15558034 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11425009 0,15548829 ! protein export from nucleus GO:0006611 24 16 0,000 0,11425009 0,15539633 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11425009 0,15530449 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11425009 0,15521276 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11425009 0,15512113 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11425009 0,15502962 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11425009 0,15493821 ! diencephalon development GO:0021536 25 16 0,000 0,11425009 0,15484691 ! neural crest cell migration GO:0001755 24 16 0,000 0,11425009 0,15475571 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11425009 0,15466463 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11425009 0,15457365 ! steroid catabolic process GO:0006706 22 16 0,000 0,11425009 0,15448278 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11425009 0,15439201 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11425009 0,15430135 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11425009 0,1542108 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11425009 0,15412035 GO:0007339|binding of sperm to zona pellucida, ! nerve development GO:0021675 18 16 0,000 0,11425009 0,15403001 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11425009 0,15393978 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11425009 0,15384965 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,11498861 0,15475355 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,119937 0,16131877 ! T cell activation GO:0042110 134 79 1,000 0,119937 0,16122449 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,12094418 0,16248342 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,12094418 0,16238856 ! negative regulation of defense response GO:0031348 19 17 0,000 0,12094418 0,16229382 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,12094418 0,16219919 ! glycerol metabolic process GO:0006071 20 17 0,000 0,12094418 0,16210467 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,12094418 0,16201026 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,12094418 0,16191596 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,12094418 0,16182176 ! signal complex assembly GO:0007172 29 17 0,000 0,12094418 0,16172768 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,12094418 0,16163371 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,12094418 0,16153984 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,12094418 0,16144609 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,12094418 0,16135244 ! memory GO:0007613 25 17 0,000 0,12094418 0,1612589 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,12094418 0,16116548 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,12094418 0,16107215 ! regulation of viral genome replication GO:0045069 24 17 0,000 0,12094418 0,16097894 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,12094418 0,16088584 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,12094418 0,16079284 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,12094418 0,16069995 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,12094418 0,16060717 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,12094418 0,16051449 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,12094418 0,16042192 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,12094418 0,16032946 ! membrane budding GO:0006900 29 17 0,000 0,12094418 0,1602371 ! heme metabolic process GO:0042168 27 17 0,000 0,12094418 0,16014485 ! stem cell differentiation GO:0048863 36 17 0,000 0,12094418 0,16005271 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,12094418 0,15996067 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,12094418 0,15986874 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,12094418 0,15977692 ! sensory perception of pain GO:0019233 23 17 0,000 0,12094418 0,1596852 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,12094418 0,15959358 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,12094418 0,15950207 ! synaptogenesis GO:0007416 24 17 0,000 0,12094418 0,15941067 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,12094418 0,15931936 GO:0046467|membrane lipid biosynthetic process, ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,12094418 0,15922817 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,12094418 0,15913708 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,12094418 0,15904609 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,12094418 0,15895521 ! forebrain development GO:0030900 131 80 1,000 0,12243092 0,16081731 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,12493754 0,16401618 ! response to protein stimulus GO:0051789 111 81 1,000 0,12493754 0,16392261 ! regulation of neurological system process GO:0031644 122 81 1,000 0,12493754 0,16382916 ! vitamin metabolic process GO:0006766 103 81 1,000 0,12493754 0,16373581 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,12493754 0,16364256 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 1,000 0,12745653 0,16684691 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,12758806 0,16692408 ! positive regulation of translation GO:0045727 28 18 0,000 0,12758806 0,16682918 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12758806 0,1667344 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12758806 0,16663971 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12758806 0,16654514 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12758806 0,16645067 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12758806 0,16635631 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12758806 0,16626206 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12758806 0,16616791 ! axis specification GO:0009798 26 18 0,000 0,12758806 0,16607387 ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12758806 0,16597994 ! pancreas development GO:0031016 26 18 0,000 0,12758806 0,16588611 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12758806 0,16579239 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12758806 0,16569878 ! pigmentation during development GO:0048066 31 18 0,000 0,12758806 0,16560527 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12758806 0,16551186 ! fucose metabolic process GO:0006004 26 18 0,000 0,12758806 0,16541857 ! response to fungus GO:0009620 19 18 0,000 0,12758806 0,16532537 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12758806 0,16523228 ! heart process GO:0003015 27 18 0,000 0,12758806 0,1651393 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12758806 0,16504642 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12758806 0,16495365 ! visual learning GO:0008542 35 18 0,000 0,12758806 0,16486098 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12758806 0,16476841 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12758806 0,16467595 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12758806 0,16458359 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12758806 0,16449133 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12758806 0,16439918 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12758806 0,16430713 ! cell-cell recognition GO:0009988 20 18 0,000 0,12758806 0,16421518 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12758806 0,16412334 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12758806 0,1640316 ! regulation of glucose import GO:0046324 21 18 0,000 0,12758806 0,16393996 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,12758806 0,16384843 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,12758806 0,163757 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,12998757 0,16674368 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,13253033 0,16991068 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,1341821 0,1719325 ! positive regulation of ossification GO:0045778 30 19 0,000 0,1341821 0,17183677 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,1341821 0,17174114 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,1341821 0,17164563 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,1341821 0,17155021 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,1341821 0,17145491 ! regeneration GO:0031099 32 19 0,000 0,1341821 0,17135971 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,1341821 0,17126461 ! sensory perception of taste GO:0050909 23 19 0,000 0,1341821 0,17116963 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,1341821 0,17107474 ! peroxisome organization GO:0007031 29 19 0,000 0,1341821 0,17097996 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,1341821 0,17088529 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,1341821 0,17079072 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,1341821 0,17069626 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,1341821 0,1706019 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,1341821 0,17050764 ! plasma membrane fusion GO:0045026 23 19 0,000 0,1341821 0,17041349 ! vasodilation GO:0042311 33 19 0,000 0,1341821 0,17031945 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,1341821 0,1702255 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,1341821 0,17013166 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,1341821 0,17003793 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,1341821 0,16994429 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,1341821 0,16985076 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,1341821 0,16975734 ! sarcomere organization GO:0045214 23 19 0,000 0,1341821 0,16966401 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,1341821 0,16957079 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,1341821 0,16947767 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,1341821 0,16938465 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,1341821 0,16929174 GO:0043450|alkene biosynthetic process, ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,1341821 0,16919892 ! protein stabilization GO:0050821 26 19 0,000 0,1341821 0,16910621 ! rRNA metabolic process GO:0016072 107 85 1,000 0,1350845 0,17015025 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,13764977 0,17328652 ! female pregnancy GO:0007565 130 87 1,000 0,14022582 0,17643292 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,14022582 0,17633645 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,14072668 0,1768696 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,14072668 0,176773 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,14072668 0,17667651 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,14072668 0,17658012 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,14072668 0,17648384 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,14072668 0,17638766 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,14072668 0,17629159 ! spinal cord development GO:0021510 31 20 0,000 0,14072668 0,17619563 ! response to ethanol GO:0045471 37 20 0,000 0,14072668 0,17609976 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,14072668 0,176004 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,14072668 0,17590835 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,14072668 0,1758128 ! chromosome condensation GO:0030261 31 20 0,000 0,14072668 0,17571735 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,14072668 0,17562201 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,14072668 0,17552677 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,14072668 0,17543163 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,14072668 0,1753366 ! DNA modification GO:0006304 28 20 0,000 0,14072668 0,17524167 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,14072668 0,17514684 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,14072668 0,17505212 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,14072668 0,17495749 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,14072668 0,17486297 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,14072668 0,17476856 ! collagen catabolic process GO:0030574 25 20 0,000 0,14072668 0,17467424 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,14072668 0,17458002 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,14072668 0,17448591 ! alditol metabolic process GO:0019400 24 20 0,000 0,14072668 0,1743919 ! actin filament-based movement GO:0030048 34 20 0,000 0,14072668 0,17429799 ! protein processing GO:0016485 114 88 1,000 0,14281234 0,176786 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,14540904 0,1799036 ! regulation of cell killing GO:0031341 34 21 0,000 0,14722216 0,18204891 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,14722216 0,18195109 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14722216 0,18185337 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14722216 0,18175575 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14722216 0,18165825 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14722216 0,18156084 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,14722216 0,18146354 ! vesicle docking GO:0048278 27 21 0,000 0,14722216 0,18136635 ! phototransduction GO:0007602 25 21 0,000 0,14722216 0,18126926 ! visual behavior GO:0007632 39 21 0,000 0,14722216 0,18117227 ! ovarian follicle development GO:0001541 30 21 0,000 0,14722216 0,18107538 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14722216 0,1809786 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14722216 0,18088193 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14722216 0,18078535 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14722216 0,18068888 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14722216 0,18059252 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14722216 0,18049625 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14722216 0,18040009 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14722216 0,18030403 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14722216 0,18020807 ! fatty acid transport GO:0015908 30 21 0,000 0,14722216 0,18011222 ! platelet activation GO:0030168 28 21 0,000 0,14722216 0,18001646 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14722216 0,17992081 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,14722216 0,17982526 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,14722216 0,17972981 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14722216 0,17963447 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14722216 0,17953922 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,14722216 0,17944408 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14722216 0,17934903 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14722216 0,17925409 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14722216 0,17915924 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14722216 0,1790645 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14722216 0,17896986 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14722216 0,17887531 ! leukocyte differentiation GO:0002521 143 90 1,000 0,14801562 0,17974442 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,15325725 0,18601144 ! DNA recombination GO:0006310 146 92 1,000 0,15325725 0,18591333 ! sulfur metabolic process GO:0006790 118 92 1,000 0,15325725 0,18581533 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,15366891 0,18621628 ! viral genome replication GO:0019079 29 22 0,000 0,15366891 0,18611822 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15366891 0,18602026 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15366891 0,1859224 ! leukocyte adhesion GO:0007159 38 22 0,000 0,15366891 0,18582465 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,15366891 0,18572701 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,15366891 0,18562946 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,15366891 0,18553202 ! vasculogenesis GO:0001570 33 22 0,000 0,15366891 0,18543468 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,15366891 0,18533744 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,15366891 0,1852403 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,15366891 0,18514326 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15366891 0,18504633 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,15366891 0,1849495 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,15366891 0,18485277 ! regulation of behavior GO:0050795 38 22 0,000 0,15366891 0,18475614 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15366891 0,18465961 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15366891 0,18456318 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15366891 0,18446685 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15366891 0,18437063 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15366891 0,1842745 ! blastocyst development GO:0001824 37 22 0,000 0,15366891 0,18417847 ! neural tube closure GO:0001843 33 22 0,000 0,15366891 0,18408255 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! neuron fate commitment GO:0048663 32 23 0,000 0,16006729 0,19164746 ! embryonic pattern specification GO:0009880 31 23 0,000 0,16006729 0,19154774 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,16006729 0,19144813 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,16006729 0,19134863 ! vesicle targeting GO:0006903 32 23 0,000 0,16006729 0,19124923 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,16006729 0,19114993 ! osteoblast differentiation GO:0001649 40 23 0,000 0,16006729 0,19105073 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,16006729 0,19095164 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,16006729 0,19085265 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,16006729 0,19075376 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,16006729 0,19065498 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,16006729 0,1905563 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,16006729 0,19045772 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,16006729 0,19035924 ! cell fate determination GO:0001709 45 23 0,000 0,16006729 0,19026086 ! pentose metabolic process GO:0019321 31 23 0,000 0,16006729 0,19016258 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,16006729 0,19006441 ! spermatid development GO:0007286 33 23 0,000 0,16006729 0,18996634 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,16006729 0,18986837 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,16006729 0,1897705 ! telomere organization GO:0032200 32 23 0,000 0,16006729 0,18967273 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,16006729 0,18957506 ! regulation of amine transport GO:0051952 38 23 0,000 0,16006729 0,18947749 ! liver development GO:0001889 40 23 0,000 0,16006729 0,18938002 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,16384638 0,1937515 ! protein maturation GO:0051604 129 96 1,000 0,16384638 0,19365194 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16641766 0,19658994 ! initiation of viral infection GO:0019059 42 24 0,000 0,16641766 0,19648902 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16641766 0,19638821 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16641766 0,1962875 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,16641766 0,19618689 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,16641766 0,19608638 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16641766 0,19598598 ! sperm motility GO:0030317 27 24 0,000 0,16641766 0,19588568 ! vacuole organization GO:0007033 39 24 0,000 0,16641766 0,19578548 ! receptor metabolic process GO:0043112 37 24 0,000 0,16641766 0,19568539 ! response to toxin GO:0009636 38 24 0,000 0,16641766 0,19558539 ! primary neural tube formation GO:0014020 35 24 0,000 0,16641766 0,1954855 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,16641766 0,19538571 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,16641766 0,19528603 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,16641766 0,19518644 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,16641766 0,19508696 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,16641766 0,19498758 ! calcium ion transport GO:0006816 167 99 1,000 0,17187216 0,20127595 ! extracellular structure organization GO:0043062 156 99 1,000 0,17187216 0,20117352 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17272038 0,20206351 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17272038 0,20196079 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17272038 0,20185817 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,17272038 0,20175565 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17272038 0,20165323 ! male gonad development GO:0008584 33 25 0,000 0,17272038 0,20155092 ! phospholipid transport GO:0015914 35 25 0,000 0,17272038 0,20144872 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17272038 0,20134661 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17272038 0,20124461 ! detection of light stimulus GO:0009583 30 25 0,000 0,17272038 0,20114272 ! leukocyte proliferation GO:0070661 39 25 0,000 0,17272038 0,20104093 GO:0032943|mononuclear cell proliferation, ! divalent metal ion transport GO:0070838 171 100 1,000 0,17456199 0,20308172 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,17456199 0,20297905 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,1789758 0,20800624 ! translational initiation GO:0006413 43 26 0,000 0,1789758 0,20790118 ! circadian rhythm GO:0007623 42 26 0,000 0,1789758 0,20779623 ! post-embryonic development GO:0009791 42 26 0,000 0,1789758 0,20769139 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,1789758 0,20758666 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,1789758 0,20748203 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,1789758 0,2073775 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,1789758 0,20727308 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,1789758 0,20716877 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,1789758 0,20706456 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18518428 0,21413969 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18518428 0,21403208 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18518428 0,21392458 ! membrane docking GO:0022406 39 27 0,000 0,18518428 0,21381719 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18518428 0,21370991 ! catechol metabolic process GO:0009712 43 27 0,000 0,18518428 0,21360273 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18518428 0,21349566 ! acute-phase response GO:0006953 42 27 0,000 0,18518428 0,2133887 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18518428 0,21328184 ! myofibril assembly GO:0030239 36 27 0,000 0,18518428 0,2131751 GO:0055002|striated muscle cell development, ! natural killer cell activation GO:0030101 35 27 0,000 0,18518428 0,21306845 ! lipid oxidation GO:0034440 38 27 0,000 0,18518428 0,21296192 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18518428 0,21285549 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18518428 0,21274917 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,18518428 0,21264296 ! gene silencing GO:0016458 41 27 0,000 0,18518428 0,21253685 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,19134616 0,21949934 ! phenol metabolic process GO:0018958 44 28 0,000 0,19134616 0,21938992 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,19134616 0,2192806 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,19134616 0,2191714 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,19134616 0,21906231 ! cell junction assembly GO:0034329 56 28 0,000 0,19134616 0,21895332 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,19134616 0,21884444 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,19134616 0,21873567 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,19134616 0,21862701 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,19134616 0,21851846 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,19134616 0,21841001 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,19134616 0,21830167 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,19134616 0,21819344 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,19134616 0,21808532 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,19134616 0,2179773 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,19134616 0,21786939 ! mesoderm formation GO:0001707 46 28 0,000 0,19134616 0,21776159 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,19134616 0,21765389 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,19134616 0,2175463 ! BMP signaling pathway GO:0030509 40 28 0,000 0,19134616 0,21743882 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,19134616 0,21733144 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,19134616 0,21722417 ! neural tube formation GO:0001841 41 28 0,000 0,19134616 0,21711701 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,1974618 0,22394583 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1974618 0,22383545 ! ovulation cycle process GO:0022602 41 29 0,000 0,1974618 0,22372519 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,1974618 0,22361503 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1974618 0,22350499 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1974618 0,22339505 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,1974618 0,22328522 ! muscle cell development GO:0055001 38 29 0,000 0,1974618 0,2231755 ! formation of primary germ layer GO:0001704 48 29 0,000 0,1974618 0,22306588 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1974618 0,22295637 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,20353153 0,22969702 ! collagen metabolic process GO:0032963 40 30 0,000 0,20353153 0,22958436 ! organic anion transport GO:0015711 51 30 0,000 0,20353153 0,22947182 ! cholesterol transport GO:0030301 46 30 0,000 0,20353153 0,22935939 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,20353153 0,22924707 ! spindle organization GO:0007051 37 30 0,000 0,20353153 0,22913486 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,20353153 0,22902276 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,20353153 0,22891077 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,20353153 0,22879889 ! ceramide metabolic process GO:0006672 43 30 0,000 0,20353153 0,22868711 ! ovulation cycle GO:0042698 43 30 0,000 0,20353153 0,22857545 ! hindbrain development GO:0030902 45 30 0,000 0,20353153 0,22846389 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,20353153 0,22835245 ! adult locomotory behavior GO:0008344 47 30 0,000 0,20353153 0,22824111 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,20353153 0,22812988 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,20353153 0,22801876 ! glial cell differentiation GO:0010001 55 31 0,000 0,2095557 0,23465341 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,2095557 0,23453923 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,2095557 0,23442515 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,2095557 0,23431119 ! odontogenesis GO:0042476 50 31 0,000 0,2095557 0,23419733 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,2095557 0,23408359 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,2095557 0,23396996 ! metanephros development GO:0001656 58 31 0,000 0,2095557 0,23385644 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,2095557 0,23374302 ! cell fate specification GO:0001708 37 31 0,000 0,2095557 0,23362972 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,2095557 0,23351653 ! RNA modification GO:0009451 40 31 0,000 0,2095557 0,23340345 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,21553465 0,23994661 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,21553465 0,23983053 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,21553465 0,23971455 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,21553465 0,23959869 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,21553465 0,23948295 ! cytokine production GO:0001816 44 32 0,000 0,21553465 0,23936731 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,22146872 0,24583883 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,22146872 0,24572023 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,22146872 0,24560176 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,22146872 0,2454834 ! sister chromatid segregation GO:0000819 46 33 0,000 0,22146872 0,24536515 ! actomyosin structure organization GO:0031032 43 33 0,000 0,22146872 0,24524701 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,22146872 0,24512899 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,22146872 0,24501109 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,22146872 0,24489329 ! female gonad development GO:0008585 49 33 0,000 0,22146872 0,24477561 ! positive regulation of cell development GO:0010720 54 33 0,000 0,22146872 0,24465804 ! lipid homeostasis GO:0055088 55 33 0,000 0,22146872 0,24454059 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,22146872 0,24442325 ! cytokinesis GO:0000910 52 33 0,000 0,22146872 0,24430602 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,22146872 0,2441889 ! mRNA catabolic process GO:0006402 48 34 0,000 0,22735823 0,2505625 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,22735823 0,25044249 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,22735823 0,25032261 ! feeding behavior GO:0007631 45 34 0,000 0,22735823 0,25020284 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,22735823 0,25008318 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,22735823 0,24996364 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,22735823 0,24984421 ! neuron migration GO:0001764 46 34 0,000 0,22735823 0,24972489 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,22735823 0,24960569 ! polyol metabolic process GO:0019751 44 34 0,000 0,22735823 0,24948661 ! aerobic respiration GO:0009060 47 34 0,000 0,22735823 0,24936763 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,22735823 0,24924877 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,23320353 0,25553507 ! Notch signaling pathway GO:0007219 56 35 0,000 0,23320353 0,25541338 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,23320353 0,25529182 GO:0032313|regulation of Rab GTPase activity, ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,23320353 0,25517037 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,23320353 0,25504903 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,23320353 0,25492781 ! pigment metabolic process GO:0042440 61 35 0,000 0,23320353 0,2548067 ! protein homooligomerization GO:0051260 52 35 0,000 0,23320353 0,25468571 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,23900493 0,26089765 ! organic ether metabolic process GO:0018904 46 36 0,000 0,23900493 0,26077388 ! tissue remodeling GO:0048771 62 36 0,000 0,23900493 0,26065023 ! neural tube development GO:0021915 50 36 0,000 0,23900493 0,2605267 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,23900493 0,26040329 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,23900493 0,26027999 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,23900493 0,26015681 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,24476278 0,26629819 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,24476278 0,26617229 ! ion transmembrane transport GO:0034220 56 37 0,000 0,24476278 0,2660465 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,24476278 0,26592082 ! amino acid activation GO:0043038 52 37 0,000 0,24476278 0,26579527 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,24476278 0,26566984 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,25047738 0,27174433 ! gliogenesis GO:0042063 71 38 0,000 0,25047738 0,27161621 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,25047738 0,27148821 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,25047738 0,27136033 ! phagocytosis GO:0006909 60 38 0,000 0,25047738 0,27123257 ! maintenance of location in cell GO:0051651 69 38 0,000 0,25047738 0,27110493 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,25614907 0,2771133 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,25614907 0,27698301 ! male sex differentiation GO:0046661 53 39 0,000 0,25614907 0,27685285 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,25614907 0,27672281 ! chromatin remodeling GO:0006338 68 39 0,000 0,25614907 0,2765929 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,25614907 0,2764631 ! JNK cascade GO:0007254 54 39 0,000 0,25614907 0,27633343 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,26177817 0,28227369 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,26177817 0,28214142 ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,26177817 0,28200927 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,26177817 0,28187724 ! peptide metabolic process GO:0006518 56 40 0,000 0,26177817 0,28174534 ! inner ear development GO:0048839 57 40 0,000 0,26177817 0,28161356 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,26177817 0,2814819 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,26177817 0,28135037 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,26736499 0,28722068 ! endosome transport GO:0016197 71 41 0,000 0,26736499 0,28708659 ! striated muscle contraction GO:0006941 62 41 0,000 0,26736499 0,28695262 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,26736499 0,28681878 ! biopolymer methylation GO:0043414 62 41 0,000 0,26736499 0,28668507 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,27290984 0,29249424 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,27290984 0,29235801 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,27290984 0,2922219 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,27290984 0,29208592 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,27290984 0,29195006 ! neuromuscular process GO:0050905 79 43 0,000 0,27841305 0,29769875 ! tRNA processing GO:0008033 49 43 0,000 0,27841305 0,29756041 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,27841305 0,29742221 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,27841305 0,29728413 ! methylation GO:0032259 64 43 0,000 0,27841305 0,29714618 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,28387491 0,30283502 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,28387491 0,30269462 ! glycolysis GO:0006096 53 44 0,000 0,28387491 0,30255436 ! regulation of ion transport GO:0043269 57 44 0,000 0,28387491 0,30241422 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,28387491 0,30227421 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,28387491 0,30213434 ! RNA catabolic process GO:0006401 64 45 0,000 0,28929575 0,30776143 ! positive regulation of defense response GO:0031349 59 45 0,000 0,28929575 0,30761915 ! regulation of translational initiation GO:0006446 64 45 0,000 0,28929575 0,307477 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,28929575 0,30733498 ! cell recognition GO:0008037 58 45 0,000 0,28929575 0,30719308 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,29467586 0,31276164 ! cell redox homeostasis GO:0045454 63 46 0,000 0,29467586 0,31261738 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,29467586 0,31247325 ! regulation of ossification GO:0030278 71 46 0,000 0,29467586 0,31232925 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,29467586 0,31218539 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,30001554 0,31769602 ! viral infectious cycle GO:0019058 71 47 0,000 0,30001554 0,31754982 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,30001554 0,31740375 ! endocrine system development GO:0035270 83 47 0,000 0,30001554 0,31725782 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,30001554 0,31711202 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,30001554 0,31696635 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,30001554 0,31682082 ! chloride transport GO:0006821 67 48 0,000 0,30531511 0,32226928 ! gastrulation GO:0007369 73 48 0,000 0,30531511 0,32212145 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,30531511 0,32197375 ! regulation of endocytosis GO:0030100 63 48 0,000 0,30531511 0,32182619 ! nuclear export GO:0051168 69 48 0,000 0,30531511 0,32167877 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,30531511 0,32153148 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,31057486 0,3269209 ! sensory perception of smell GO:0007608 61 49 0,000 0,31057486 0,32677135 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,31057486 0,32662194 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,31057486 0,32647266 ! maintenance of location GO:0051235 84 49 0,000 0,31057486 0,32632351 ! membrane fusion GO:0006944 80 50 0,000 0,31579508 0,33165693 ! proton transport GO:0015992 75 50 0,000 0,31579508 0,33150556 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,31579508 0,33135433 ! hydrogen transport GO:0006818 77 51 0,000 0,32097607 0,33663701 ! adult behavior GO:0030534 80 51 0,000 0,32097607 0,33648357 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,32611813 0,34171831 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,33122153 0,3469078 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,33122153 0,3467499 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,33122153 0,34659214 ! kidney development GO:0001822 90 53 0,000 0,33122153 0,34643453 ! single fertilization GO:0007338 59 53 0,000 0,33122153 0,34627706 ! amino acid transport GO:0006865 84 54 0,000 0,33628658 0,3514126 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,33628658 0,35125302 ! glucose catabolic process GO:0006007 66 54 0,000 0,33628658 0,35109357 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,33628658 0,35093428 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,33628658 0,35077512 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,33628658 0,35061611 ! exocytosis GO:0006887 74 55 0,000 0,34131356 0,35569605 ! mesoderm development GO:0007498 76 55 0,000 0,34131356 0,35553496 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,34131356 0,35537401 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,34131356 0,35521321 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,34630275 0,36024257 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,34630275 0,36007971 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,35125444 0,36506335 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,35125444 0,36489846 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,35125444 0,36473372 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,35125444 0,36456913 ! gonad development GO:0008406 79 57 0,000 0,35125444 0,36440469 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,35616889 0,36933654 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,35616889 0,3691701 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,3610464 0,37405708 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,3610464 0,37388866 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,36588724 0,37873116 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,36588724 0,37856079 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,36588724 0,37839058 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,36588724 0,37822051 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,36588724 0,3780506 ! fertilization GO:0009566 68 60 0,000 0,36588724 0,37788085 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,37069167 0,38267094 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,37069167 0,38249926 ! extracellular matrix organization GO:0030198 103 61 0,000 0,37069167 0,38232773 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,37069167 0,38215636 ! amine catabolic process GO:0009310 90 62 0,000 0,37545998 0,38689873 ! neurotransmitter transport GO:0006836 81 62 0,000 0,37545998 0,38672546 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,37545998 0,38655235 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,38019243 0,39124948 ! appendage morphogenesis GO:0035107 93 64 0,000 0,38488929 0,3959058 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,38488929 0,39572882 ! hexose catabolic process GO:0019320 82 64 0,000 0,38488929 0,395552 ! appendage development GO:0048736 94 65 0,000 0,38955083 0,40016387 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,38955083 0,39998522 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,38955083 0,39980674 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,38955083 0,39962841 ! activation of immune response GO:0002253 83 65 0,000 0,38955083 0,39945024 ! antigen processing and presentation GO:0019882 96 66 0,000 0,3941773 0,40401417 ! acute inflammatory response GO:0002526 92 68 0,000 0,40332611 0,41320715 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,40332611 0,41302317 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,40332611 0,41283936 ! rhythmic process GO:0048511 105 68 0,000 0,40332611 0,41265571 ! inorganic anion transport GO:0015698 93 68 0,000 0,40332611 0,41247223 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,40784896 0,41691227 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,40784896 0,41672706 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,41233779 0,42112651 ! amine transport GO:0015837 101 70 0,000 0,41233779 0,4209396 ! muscle cell differentiation GO:0042692 104 71 0,000 0,41679284 0,42529882 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,41679284 0,42511021 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,42560264 0,4339034 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,42560264 0,43371115 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,43428036 0,4423582 ! amine biosynthetic process GO:0009309 97 76 0,000 0,4385703 0,44653018 ! tRNA metabolic process GO:0006399 95 76 0,000 0,4385703 0,4463326 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,44282795 0,45046629 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,44282795 0,45026715 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,44282795 0,45006818 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,44705356 0,45416218 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,44705356 0,45396167 ! cellular respiration GO:0045333 107 79 0,000 0,45124736 0,45801806 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,45124736 0,45781603 ! regulation of lyase activity GO:0051339 133 79 0,000 0,45124736 0,45761417 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,45124736 0,45741249 ! chromatin assembly GO:0031497 102 80 0,000 0,45540959 0,46142822 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,45540959 0,46122504 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,45540959 0,46102204 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,45540959 0,46081921 ! mRNA transport GO:0051028 121 81 0,000 0,45954049 0,4647947 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,46770923 0,47284889 ! regulation of defense response GO:0031347 117 84 0,000 0,47174753 0,47672202 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,47174753 0,47651266 ! sterol metabolic process GO:0016125 120 84 0,000 0,47174753 0,47630348 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,47575543 0,48013931 ! nucleosome organization GO:0034728 114 87 0,000 0,4836809 0,48792371 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,4836809 0,48770981 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,4836809 0,48749609 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,48759893 0,49122976 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,48759893 0,49101468 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,48759893 0,4907998 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,49148745 0,49449743 ! RNA localization GO:0006403 135 91 0,000 0,49917685 0,50201432 ! ATP metabolic process GO:0046034 137 91 0,000 0,49917685 0,50179491 ! response to virus GO:0009615 122 91 0,000 0,49917685 0,50157569 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,50297816 0,50517457 ! positive regulation of immune response GO:0050778 121 92 0,000 0,50297816 0,50495407 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,50675084 0,50851961 ! electron transport chain GO:0022900 123 94 0,000 0,5104951 0,51205352 ! response to oxidative stress GO:0006979 141 94 0,000 0,5104951 0,51183031 ! carboxylic acid transport GO:0046942 147 95 0,000 0,51421115 0,51533143 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,5178992 0,51880146 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,52155946 0,52224064 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,52155946 0,52201338 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,53237558 0,53260715 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,53237558 0,53237558