pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6521-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 7,000 9,327E-10 2,279E-06 ! interphase of mitotic cell cycle GO:0051329 224 98 8,000 3,864E-09 4,72E-06 ! cell cycle checkpoint GO:0000075 145 71 7,000 5,624E-09 4,58E-06 ! regulation of lipid kinase activity GO:0043550 17 8 3,000 6,044E-08 3,691E-05 ! UTP metabolic process GO:0046051 10 9 3,000 1,083E-07 5,293E-05 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! macrophage differentiation GO:0030225 15 9 3,000 1,083E-07 4,411E-05 ! CTP metabolic process GO:0046036 11 10 3,000 1,798E-07 6,274E-05 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 11 10 3,000 1,798E-07 5,49E-05 ! sex determination GO:0007530 48 24 4,000 1,843E-07 5,004E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 1,97E-07 4,812E-05 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 4,000 2,294E-07 5,095E-05 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 3,000 2,813E-07 5,726E-05 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 3,000 6,042E-07 1,135E-04 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 3,000 1,144E-06 1,996E-04 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 3,000 1,518E-06 2,473E-04 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 3,000 1,518E-06 2,318E-04 ! Notch receptor processing GO:0007220 11 5 2,000 1,613E-06 2,318E-04 ! regulation of keratinocyte differentiation GO:0045616 6 5 2,000 1,613E-06 2,189E-04 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 3,000 2,531E-06 3,254E-04 ! nuclear migration GO:0007097 13 6 2,000 3,213E-06 3,924E-04 ! L-serine biosynthetic process GO:0006564 7 6 2,000 3,213E-06 3,737E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 3,213E-06 3,568E-04 GO:0031272|regulation of pseudopodium assembly, ! triglyceride catabolic process GO:0019433 10 6 2,000 3,213E-06 3,412E-04 ! C21-steroid hormone metabolic process GO:0008207 38 21 3,000 4,886E-06 4,974E-04 ! prostate gland development GO:0030850 14 7 2,000 5,6E-06 5,472E-04 ! amyloid precursor protein catabolic process GO:0042987 15 7 2,000 5,6E-06 5,261E-04 ! glycerol ether catabolic process GO:0044269 12 7 2,000 5,6E-06 5,067E-04 GO:0046464|acylglycerol catabolic process, ! regulation of epidermal cell differentiation GO:0045604 8 7 2,000 5,6E-06 4,886E-04 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 3,000 5,947E-06 5,01E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 8,565E-06 6,974E-04 ! pyrimidine nucleoside metabolic process GO:0006213 34 24 3,000 8,565E-06 6,749E-04 ! glycerolipid catabolic process GO:0046503 14 8 2,000 8,923E-06 6,812E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 8,923E-06 6,606E-04 ! positive regulation of epidermis development GO:0045684 13 8 2,000 8,923E-06 6,411E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 8,923E-06 6,228E-04 ! myeloid leukocyte differentiation GO:0002573 46 25 3,000 1,015E-05 6,889E-04 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 1,195E-05 7,888E-04 GO:0045936|negative regulation of phosphate metabolic process, ! neutral lipid catabolic process GO:0046461 14 9 2,000 1,333E-05 8,57E-04 ! amyloid precursor protein metabolic process GO:0042982 18 9 2,000 1,333E-05 8,35E-04 ! cellular response to oxidative stress GO:0034599 43 27 3,000 1,396E-05 8,529E-04 ! establishment of organelle localization GO:0051656 122 59 4,000 1,858E-05 1,107E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 1,897E-05 1,103E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 1,897E-05 1,078E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 3,000 2,461E-05 1,366E-03 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 2,000 2,597E-05 1,41E-03 ! L-serine metabolic process GO:0006563 21 11 2,000 2,597E-05 1,379E-03 ! nucleus localization GO:0051647 22 11 2,000 2,597E-05 1,35E-03 ! positive regulation of cell motion GO:0051272 157 65 4,000 2,985E-05 1,519E-03 ! regulation of lipid metabolic process GO:0019216 132 66 4,000 3,216E-05 1,603E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 3,449E-05 1,685E-03 ! regulation of cell projection assembly GO:0060491 33 12 2,000 3,449E-05 1,652E-03 ! myeloid cell differentiation GO:0030099 126 67 4,000 3,46E-05 1,625E-03 ! membrane protein proteolysis GO:0033619 33 13 2,000 4,466E-05 2,058E-03 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of epidermis development GO:0045682 19 13 2,000 4,466E-05 2,02E-03 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 3,000 4,509E-05 2,003E-03 ! hormone biosynthetic process GO:0042446 62 37 3,000 5,034E-05 2,196E-03 ! organelle localization GO:0051640 155 74 4,000 5,595E-05 2,398E-03 ! meiosis I GO:0007127 74 38 3,000 5,603E-05 2,36E-03 ! DNA integrity checkpoint GO:0031570 82 38 3,000 5,603E-05 2,32E-03 ! regulation of protein stability GO:0031647 77 38 3,000 5,603E-05 2,281E-03 ! serine family amino acid biosynthetic process GO:0009070 19 14 2,000 5,661E-05 2,267E-03 ! negative regulation of binding GO:0051100 71 39 3,000 6,216E-05 2,449E-03 ! carbohydrate homeostasis GO:0033500 59 39 3,000 6,216E-05 2,411E-03 GO:0042593|glucose homeostasis, ! tRNA modification GO:0006400 24 15 2,000 7,047E-05 2,69E-03 ! glycoprotein catabolic process GO:0006516 33 15 2,000 7,047E-05 2,649E-03 ! ribonucleoside metabolic process GO:0009119 64 42 3,000 8,351E-05 3,091E-03 ! meiosis GO:0007126 143 81 4,000 8,627E-05 3,145E-03 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 4,000 8,627E-05 3,099E-03 ! meiotic cell cycle GO:0051321 144 82 4,000 9,146E-05 3,238E-03 ! response to oxygen levels GO:0070482 183 83 4,000 9,689E-05 3,382E-03 ! negative regulation of cell cycle process GO:0010948 35 17 2,000 1,045E-04 3,595E-03 ! signal complex assembly GO:0007172 47 17 2,000 1,045E-04 3,545E-03 ! filopodium assembly GO:0046847 42 17 2,000 1,045E-04 3,496E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 2,000 1,045E-04 3,449E-03 ! negative regulation of growth GO:0045926 168 85 4,000 1,085E-04 3,534E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 1,097E-04 3,528E-03 ! microspike assembly GO:0030035 46 18 2,000 1,249E-04 3,961E-03 ! regulation of DNA binding GO:0051101 167 89 4,000 1,349E-04 4,225E-03 ! regulation of cell cycle process GO:0010564 161 90 4,000 1,422E-04 4,397E-03 ! proximal/distal pattern formation GO:0009954 33 19 2,000 1,477E-04 4,51E-03 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 2,000 1,73E-04 5,219E-03 ! regulation of cell projection organization GO:0031344 135 51 3,000 1,794E-04 5,345E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 2,121E-04 6,242E-03 ! reciprocal meiotic recombination GO:0007131 44 22 2,000 2,319E-04 6,743E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 2,000 2,319E-04 6,664E-03 ! protein stabilization GO:0050821 41 22 2,000 2,319E-04 6,586E-03 ! hormone metabolic process GO:0042445 171 100 4,000 2,331E-04 6,544E-03 ! response to UV GO:0009411 120 55 3,000 2,407E-04 6,682E-03 ! cellular response to reactive oxygen species GO:0034614 35 23 2,000 2,656E-04 7,29E-03 ! positive regulation of cell migration GO:0030335 137 58 3,000 2,956E-04 8,024E-03 ! negative regulation of protein ubiquitination GO:0031397 10 5 1,000 2,962E-04 7,952E-03 ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 2,962E-04 7,866E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,962E-04 7,781E-03 ! hypothalamus development GO:0021854 9 5 1,000 2,962E-04 7,698E-03 ! lipoprotein particle clearance GO:0034381 10 5 1,000 2,962E-04 7,617E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 2,962E-04 7,538E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 2,962E-04 7,46E-03 ! microvillus organization GO:0032528 8 5 1,000 2,962E-04 7,384E-03 GO:0030033|microvillus assembly, ! mRNA transcription GO:0009299 10 5 1,000 2,962E-04 7,309E-03 ! positive regulation of transporter activity GO:0032411 8 5 1,000 2,962E-04 7,236E-03 GO:0032414|positive regulation of ion transmembrane transporter activity, ! lipoprotein catabolic process GO:0042159 11 5 1,000 2,962E-04 7,165E-03 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 1,000 2,962E-04 7,094E-03 ! cellular glucose homeostasis GO:0001678 6 5 1,000 2,962E-04 7,026E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 2,962E-04 6,958E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 2,962E-04 6,892E-03 ! cellular response to nutrient GO:0031670 8 5 1,000 2,962E-04 6,827E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,962E-04 6,763E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 2,962E-04 6,7E-03 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 2,962E-04 6,639E-03 GO:0048103|somatic stem cell division, ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 3,023E-04 6,713E-03 ! vasculogenesis GO:0001570 49 25 2,000 3,421E-04 7,53E-03 ! negative regulation of DNA replication GO:0008156 45 25 2,000 3,421E-04 7,462E-03 ! nucleoside metabolic process GO:0009116 91 62 3,000 3,821E-04 8,261E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 4,316E-04 9,249E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 4,316E-04 9,168E-03 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 4,316E-04 9,089E-03 ! cellular response to nutrient levels GO:0031669 45 27 2,000 4,316E-04 9,012E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 4,427E-04 9,165E-03 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 1,000 4,427E-04 9,088E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 1,000 4,427E-04 9,013E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 4,427E-04 8,938E-03 ! positive regulation of exocytosis GO:0045921 11 6 1,000 4,427E-04 8,865E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 4,427E-04 8,793E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 4,427E-04 8,722E-03 GO:0051653|spindle localization, ! astrocyte development GO:0014002 16 6 1,000 4,427E-04 8,652E-03 ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 4,427E-04 8,583E-03 ! negative regulation of cell-cell adhesion GO:0022408 13 6 1,000 4,427E-04 8,516E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 4,427E-04 8,449E-03 ! Schwann cell development GO:0014044 15 6 1,000 4,427E-04 8,384E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 4,427E-04 8,319E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 4,427E-04 8,256E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 4,814E-04 8,91E-03 ! negative regulation of cell growth GO:0030308 142 67 3,000 5,139E-04 9,44E-03 ! embryonic limb morphogenesis GO:0030326 139 67 3,000 5,139E-04 9,37E-03 GO:0035113|embryonic appendage morphogenesis, ! cell projection assembly GO:0030031 138 68 3,000 5,437E-04 9,839E-03 ! negative regulation of cell size GO:0045792 144 69 3,000 5,747E-04 0,01032403 ! cellular hormone metabolic process GO:0034754 120 69 3,000 5,747E-04 0,01024868 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 5,747E-04 0,01017441 ! lung development GO:0030324 165 69 3,000 5,747E-04 0,01010121 ! urogenital system development GO:0001655 149 69 3,000 5,747E-04 0,01002906 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 5,918E-04 0,01025443 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 5,918E-04 0,01018221 GO:0043433|negative regulation of transcription factor activity, ! regulation of B cell activation GO:0050864 55 30 2,000 5,918E-04 0,01011101 ! negative regulation of kinase activity GO:0033673 145 70 3,000 6,07E-04 0,01029742 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 6,175E-04 0,01040453 ! mRNA stabilization GO:0048255 18 7 1,000 6,175E-04 0,01033326 GO:0043489|RNA stabilization, ! lipoprotein transport GO:0042953 14 7 1,000 6,175E-04 0,01026297 ! spindle checkpoint GO:0031577 16 7 1,000 6,175E-04 0,01019362 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 1,000 6,175E-04 0,01012521 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 6,175E-04 0,01005771 ! negative regulation of nuclear division GO:0051784 15 7 1,000 6,175E-04 9,991E-03 GO:0045839|negative regulation of mitosis, ! appendage morphogenesis GO:0035107 150 72 3,000 6,753E-04 0,01085307 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 3,000 6,753E-04 0,01078214 ! actin filament organization GO:0007015 167 72 3,000 6,753E-04 0,01071212 ! appendage development GO:0048736 151 73 3,000 7,114E-04 0,01121212 GO:0060173|limb development, ! negative regulation of transferase activity GO:0051348 155 74 3,000 7,488E-04 0,01172677 ! respiratory system development GO:0060541 175 74 3,000 7,488E-04 0,01165208 ! triglyceride metabolic process GO:0006641 46 33 2,000 7,858E-04 0,01214981 ! regulation of transcription factor activity GO:0051090 137 75 3,000 7,876E-04 0,01210205 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 3,000 7,876E-04 0,01202642 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 8,204E-04 0,01244892 ! male meiosis GO:0007140 9 8 1,000 8,204E-04 0,01237207 ! T-helper 1 type immune response GO:0042088 12 8 1,000 8,204E-04 0,01229617 ! hemoglobin metabolic process GO:0020027 14 8 1,000 8,204E-04 0,01222119 ! astrocyte differentiation GO:0048708 19 8 1,000 8,204E-04 0,01214712 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 8,204E-04 0,01207395 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 8,204E-04 0,01200165 ! regulation of vascular permeability GO:0043114 12 8 1,000 8,204E-04 0,01193021 ! Schwann cell differentiation GO:0014037 21 8 1,000 8,204E-04 0,01185962 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 8,204E-04 0,01178986 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 8,204E-04 0,01172091 ! mast cell activation GO:0045576 14 8 1,000 8,204E-04 0,01165276 ! gas homeostasis GO:0033483 14 8 1,000 8,204E-04 0,01158541 ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 1,000 8,204E-04 0,01151882 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 8,204E-04 0,011453 ! B cell receptor signaling pathway GO:0050853 22 8 1,000 8,204E-04 0,01138793 ! negative regulation of DNA replication initiation GO:0032297 10 8 1,000 8,204E-04 0,01132359 GO:0000076|DNA replication checkpoint, ! serine family amino acid metabolic process GO:0009069 56 34 2,000 8,584E-04 0,01178078 ! DNA damage checkpoint GO:0000077 78 35 2,000 9,351E-04 0,01276174 ! negative regulation of DNA metabolic process GO:0051053 65 35 2,000 9,351E-04 0,01269084 ! steroid biosynthetic process GO:0006694 146 79 3,000 9,572E-04 0,0129199 ! negative regulation of organelle organization GO:0010639 181 80 3,000 1,003E-03 0,01346774 ! negative regulation of DNA binding GO:0043392 67 36 2,000 1,016E-03 0,01356287 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,051E-03 0,01395446 ! cell proliferation in forebrain GO:0021846 18 9 1,000 1,051E-03 0,01387903 ! induction of positive chemotaxis GO:0050930 17 9 1,000 1,051E-03 0,01380441 ! artery development GO:0060840 25 9 1,000 1,051E-03 0,01373059 GO:0048844|artery morphogenesis, ! regulation of glycolysis GO:0006110 20 9 1,000 1,051E-03 0,01365756 ! cerebral cortex cell migration GO:0021795 18 9 1,000 1,051E-03 0,0135853 ! microtubule bundle formation GO:0001578 22 9 1,000 1,051E-03 0,01351379 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 1,000 1,051E-03 0,01344304 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,051E-03 0,01337303 ! receptor clustering GO:0043113 20 9 1,000 1,051E-03 0,01330374 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 1,051E-03 0,01323516 ! postreplication repair GO:0006301 25 9 1,000 1,051E-03 0,01316729 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 1,051E-03 0,01310011 ! negative regulation of cell adhesion GO:0007162 94 37 2,000 1,101E-03 0,0136556 ! tissue remodeling GO:0048771 78 37 2,000 1,101E-03 0,01358663 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 1,101E-03 0,01351836 ! neutral lipid metabolic process GO:0006638 54 38 2,000 1,191E-03 0,01454503 GO:0006639|acylglycerol metabolic process, ! cellular response to insulin stimulus GO:0032869 85 38 2,000 1,191E-03 0,01447266 ! mitotic cell cycle checkpoint GO:0007093 76 39 2,000 1,285E-03 0,01553845 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,309E-03 0,01575341 ! lung alveolus development GO:0048286 26 10 1,000 1,309E-03 0,01567619 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 1,309E-03 0,01559972 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 1,309E-03 0,01552399 ! epithelial cell development GO:0002064 21 10 1,000 1,309E-03 0,015449 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 1,309E-03 0,01537472 ! regulation of bone resorption GO:0045124 25 10 1,000 1,309E-03 0,01530116 ! protein heterooligomerization GO:0051291 17 10 1,000 1,309E-03 0,0152283 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 1,309E-03 0,01515613 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,309E-03 0,01508463 GO:0043470|regulation of carbohydrate catabolic process, ! glycerol ether metabolic process GO:0006662 57 40 2,000 1,383E-03 0,01586685 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 1,487E-03 0,01697111 ! RNA modification GO:0009451 64 41 2,000 1,487E-03 0,01689217 ! negative regulation of muscle development GO:0048635 27 11 1,000 1,594E-03 0,01803007 ! telencephalon cell migration GO:0022029 23 11 1,000 1,594E-03 0,01794699 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,594E-03 0,01786466 ! blood vessel remodeling GO:0001974 30 11 1,000 1,594E-03 0,01778309 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,594E-03 0,01770225 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,594E-03 0,01762215 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 1,594E-03 0,01754278 ! DNA methylation GO:0006306 19 11 1,000 1,594E-03 0,01746411 GO:0006305|DNA alkylation, ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 1,594E-03 0,01738614 ! T cell receptor signaling pathway GO:0050852 29 11 1,000 1,594E-03 0,01730887 ! organic ether metabolic process GO:0018904 59 42 2,000 1,595E-03 0,0172367 ! cytokinesis GO:0000910 84 42 2,000 1,595E-03 0,01716077 ! gland development GO:0048732 220 91 3,000 1,618E-03 0,01733708 ! epithelial cell differentiation GO:0030855 83 43 2,000 1,707E-03 0,01821335 ! regulation of myeloid cell differentiation GO:0045637 105 43 2,000 1,707E-03 0,01813416 ! response to reactive oxygen species GO:0000302 75 44 2,000 1,825E-03 0,01929909 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 1,825E-03 0,01921591 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,906E-03 0,01998516 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 1,906E-03 0,01989976 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 1,906E-03 0,01981508 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,906E-03 0,01973112 ! forebrain cell migration GO:0021885 24 12 1,000 1,906E-03 0,01964786 ! entry into host cell GO:0030260 34 12 1,000 1,906E-03 0,01956531 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! synaptic vesicle exocytosis GO:0016079 22 12 1,000 1,906E-03 0,01948344 ! histone acetylation GO:0016573 27 12 1,000 1,906E-03 0,01940226 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 1,906E-03 0,01932176 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,906E-03 0,01924191 ! regulation of leukocyte migration GO:0002685 29 12 1,000 1,906E-03 0,01916273 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 1,906E-03 0,01908419 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 1,906E-03 0,0190063 ! embryonic placenta development GO:0001892 21 12 1,000 1,906E-03 0,01892904 ! response to cold GO:0009409 17 12 1,000 1,906E-03 0,0188524 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 1,947E-03 0,01918296 ! response to insulin stimulus GO:0032868 98 47 2,000 2,207E-03 0,0216578 ! regulation of chemokine production GO:0032642 18 13 1,000 2,245E-03 0,02193341 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 2,245E-03 0,02184602 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 2,245E-03 0,02175933 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,245E-03 0,02167333 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 2,245E-03 0,021588 ! regulation of mRNA stability GO:0043488 32 13 1,000 2,245E-03 0,02150334 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 1,000 2,245E-03 0,02141934 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 2,245E-03 0,021336 ! regulation of steroid biosynthetic process GO:0050810 20 13 1,000 2,245E-03 0,0212533 ! positive regulation of cell cycle GO:0045787 96 48 2,000 2,345E-03 0,02212072 ! cellular component disassembly GO:0022411 89 48 2,000 2,345E-03 0,02203564 ! positive regulation of DNA binding GO:0043388 83 48 2,000 2,345E-03 0,02195121 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 2,488E-03 0,02320027 ! rRNA transcription GO:0009303 28 14 1,000 2,609E-03 0,02423649 ! regulation of S phase GO:0033261 26 14 1,000 2,609E-03 0,02414468 ! regulation of RNA stability GO:0043487 33 14 1,000 2,609E-03 0,02405357 ! positive regulation of binding GO:0051099 88 52 2,000 2,949E-03 0,02708289 ! Notch signaling pathway GO:0007219 111 52 2,000 2,949E-03 0,02698146 ! cellular amino acid biosynthetic process GO:0008652 80 52 2,000 2,949E-03 0,02688078 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 3E-03 0,02724295 ! pteridine and derivative biosynthetic process GO:0042559 20 15 1,000 3E-03 0,02714205 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3E-03 0,0270419 ! regulation of cell-cell adhesion GO:0022407 35 15 1,000 3E-03 0,02694248 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 3E-03 0,02684379 ! regulation of exocytosis GO:0017157 26 15 1,000 3E-03 0,02674582 ! G1/S transition checkpoint GO:0031575 37 15 1,000 3E-03 0,02664856 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 3E-03 0,02655201 ! muscle maintenance GO:0046716 26 15 1,000 3E-03 0,02645615 ! intestinal absorption GO:0050892 31 15 1,000 3E-03 0,02636099 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 3E-03 0,0262665 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 3,113E-03 0,02716336 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein ubiquitination GO:0031396 28 16 1,000 3,416E-03 0,02969792 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 3,416E-03 0,0295926 ! regulation of transmembrane transporter activity GO:0022898 27 16 1,000 3,416E-03 0,02948804 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! pituitary gland development GO:0021983 30 16 1,000 3,416E-03 0,02938421 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 3,416E-03 0,0292811 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 3,416E-03 0,02917872 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 3,416E-03 0,02907705 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of cell motion GO:0051271 142 55 2,000 3,459E-03 0,02933939 ! regulation of DNA replication GO:0006275 105 56 2,000 3,64E-03 0,03076935 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 3,857E-03 0,03249575 ! glial cell development GO:0021782 28 17 1,000 3,857E-03 0,03238408 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 3,857E-03 0,03227317 GO:0031114|regulation of microtubule depolymerization, ! regulation of protein binding GO:0043393 33 17 1,000 3,857E-03 0,03216303 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 3,857E-03 0,03205363 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 3,857E-03 0,03194497 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 3,857E-03 0,03183705 ! limbic system development GO:0021761 40 18 1,000 4,324E-03 0,03556771 ! heart looping GO:0001947 34 18 1,000 4,324E-03 0,03544835 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 4,324E-03 0,0353298 ! neural crest cell migration GO:0001755 41 18 1,000 4,324E-03 0,03521203 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 4,324E-03 0,03509505 ! aromatic compound biosynthetic process GO:0019438 26 18 1,000 4,324E-03 0,03497884 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 4,324E-03 0,0348634 ! cytokine-mediated signaling pathway GO:0019221 112 61 2,000 4,632E-03 0,03722542 ! regulation of lipid biosynthetic process GO:0046890 28 19 1,000 4,815E-03 0,03857031 ! memory GO:0007613 34 19 1,000 4,815E-03 0,03844426 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 4,815E-03 0,03831903 ! cerebral cortex development GO:0021987 40 19 1,000 4,815E-03 0,03819462 ! pigmentation during development GO:0048066 42 19 1,000 4,815E-03 0,03807102 ! neuromuscular junction development GO:0007528 43 19 1,000 4,815E-03 0,03794821 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 4,815E-03 0,03782619 ! peptide cross-linking GO:0018149 39 19 1,000 4,815E-03 0,03770495 ! regulation of steroid metabolic process GO:0019218 35 19 1,000 4,815E-03 0,03758448 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 4,848E-03 0,03772128 ! tRNA processing GO:0008033 102 62 2,000 4,848E-03 0,03760153 ! regulation of homeostatic process GO:0032844 148 62 2,000 4,848E-03 0,03748253 ! regulation of protein complex assembly GO:0043254 132 63 2,000 5,07E-03 0,03907596 ! regulation of mitosis GO:0007088 112 63 2,000 5,07E-03 0,03895308 GO:0051783|regulation of nuclear division, ! response to peptide hormone stimulus GO:0043434 129 64 2,000 5,299E-03 0,04057816 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 5,331E-03 0,04070025 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 5,331E-03 0,04057346 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 5,331E-03 0,04044745 ! protein amino acid acetylation GO:0006473 41 20 1,000 5,331E-03 0,04032223 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 5,331E-03 0,04019778 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 5,331E-03 0,04007409 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 5,331E-03 0,03995117 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 5,331E-03 0,03982899 ! cellular response to unfolded protein GO:0034620 35 20 1,000 5,331E-03 0,03970756 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 1,000 5,331E-03 0,03958687 ! negative regulation of T cell activation GO:0050868 41 20 1,000 5,331E-03 0,03946691 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 5,773E-03 0,04260981 ! lipid phosphorylation GO:0046834 43 21 1,000 5,871E-03 0,04320281 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 5,871E-03 0,04307307 ! prostaglandin metabolic process GO:0006693 43 21 1,000 5,871E-03 0,04294411 GO:0006692|prostanoid metabolic process, ! diencephalon development GO:0021536 36 21 1,000 5,871E-03 0,04281592 ! positive regulation of inflammatory response GO:0050729 41 21 1,000 5,871E-03 0,04268849 ! chromosome segregation GO:0007059 127 67 2,000 6,02E-03 0,04363832 ! pteridine and derivative metabolic process GO:0042558 32 22 1,000 6,435E-03 0,0465119 ! hindlimb morphogenesis GO:0035137 47 22 1,000 6,435E-03 0,0463747 ! cellular response to starvation GO:0009267 37 22 1,000 6,435E-03 0,0462383 ! apoptotic nuclear changes GO:0030262 34 22 1,000 6,435E-03 0,04610271 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 6,435E-03 0,0459679 ! positive regulation of locomotion GO:0040017 44 22 1,000 6,435E-03 0,04583389 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 1,000 6,435E-03 0,04570065 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 6,435E-03 0,04556818 ! positive regulation of B cell activation GO:0050871 42 22 1,000 6,435E-03 0,04543648 ! germ cell development GO:0007281 133 70 2,000 6,797E-03 0,04785106 ! protein maturation by peptide bond cleavage GO:0051605 118 70 2,000 6,797E-03 0,04771355 ! regulation of chemotaxis GO:0050920 45 23 1,000 7,023E-03 0,04915896 ! visual behavior GO:0007632 46 23 1,000 7,023E-03 0,0490185 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 7,023E-03 0,04887885 GO:0010810|regulation of cell-substrate adhesion, ! vesicle targeting GO:0006903 49 23 1,000 7,023E-03 0,04873999 ! DNA modification GO:0006304 36 23 1,000 7,023E-03 0,04860191 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 7,068E-03 0,04877918 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 7,634E-03 0,05253246 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 7,634E-03 0,05238489 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 7,634E-03 0,05223816 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 7,634E-03 0,05209224 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! pallium development GO:0021543 56 24 1,000 7,634E-03 0,05194714 ! synaptic vesicle transport GO:0048489 52 24 1,000 7,634E-03 0,05180284 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 7,634E-03 0,05165934 ! platelet activation GO:0030168 41 24 1,000 7,634E-03 0,05151663 ! negative regulation of catabolic process GO:0009895 52 24 1,000 7,634E-03 0,05137472 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 7,634E-03 0,05123358 ! eye development GO:0001654 155 75 2,000 8,219E-03 0,05500844 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 8,268E-03 0,05518579 ! regulation of transmembrane transport GO:0034762 39 25 1,000 8,268E-03 0,05503542 ! receptor metabolic process GO:0043112 53 25 1,000 8,268E-03 0,05488587 ! regulation of behavior GO:0050795 48 25 1,000 8,268E-03 0,05473712 ! interaction with host GO:0051701 66 25 1,000 8,268E-03 0,05458919 ! cell-matrix adhesion GO:0007160 181 76 2,000 8,522E-03 0,05611884 ! learning or memory GO:0007611 161 76 2,000 8,522E-03 0,05596798 ! regulation of vesicle-mediated transport GO:0060627 136 77 2,000 8,833E-03 0,05784994 ! regulation of catabolic process GO:0009894 173 77 2,000 8,833E-03 0,05769527 ! myelination GO:0042552 50 26 1,000 8,925E-03 0,05814066 ! initiation of viral infection GO:0019059 60 26 1,000 8,925E-03 0,05798604 ! macromolecular complex disassembly GO:0032984 54 26 1,000 8,925E-03 0,05783223 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 8,925E-03 0,05767923 ! digestive system process GO:0022600 49 26 1,000 8,925E-03 0,05752704 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 8,925E-03 0,05737566 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 8,925E-03 0,05722506 ! neural crest cell development GO:0014032 59 26 1,000 8,925E-03 0,05707526 GO:0014033|neural crest cell differentiation, ! positive regulation of nuclear division GO:0051785 41 26 1,000 8,925E-03 0,05692624 GO:0045840|positive regulation of mitosis, ! neural tube closure GO:0001843 58 26 1,000 8,925E-03 0,05677799 GO:0060606|tube closure, ! tube lumen formation GO:0035148 59 27 1,000 9,604E-03 0,06094187 ! response to starvation GO:0042594 47 27 1,000 9,604E-03 0,06078399 ! regulation of chromosome organization GO:0033044 49 27 1,000 9,604E-03 0,06062693 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 9,604E-03 0,06047067 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 0,01030576 0,06472228 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01030576 0,06455633 ! dendrite development GO:0016358 67 28 1,000 0,01030576 0,06439122 ! negative regulation of protein modification process GO:0031400 66 28 1,000 0,01030576 0,06422696 ! fat cell differentiation GO:0045444 57 28 1,000 0,01030576 0,06406353 ! sperm motility GO:0030317 37 28 1,000 0,01030576 0,06390093 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 0,01030576 0,06373916 ! cell-substrate adhesion GO:0031589 189 82 2,000 0,01048261 0,06466925 ! cellular lipid catabolic process GO:0044242 150 83 2,000 0,01083255 0,06665975 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01102953 0,06770137 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01102953 0,0675317 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01102953 0,06736287 ! primary neural tube formation GO:0014020 61 29 1,000 0,01102953 0,06719488 ! somitogenesis GO:0001756 52 29 1,000 0,01102953 0,06702773 ! response to metal ion GO:0010038 158 84 2,000 0,01118919 0,06782923 ! cholesterol metabolic process GO:0008203 148 85 2,000 0,01155254 0,06985856 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 0,01155254 0,06968607 ! immune response-activating signal transduction GO:0002757 58 30 1,000 0,01177508 0,0708535 GO:0002764|immune response-regulating signal transduction, ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01177508 0,07067942 ! neurotransmitter secretion GO:0007269 55 30 1,000 0,01177508 0,07050618 ! male gonad development GO:0008584 56 31 1,000 0,01254215 0,07491557 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01254215 0,07473284 ! erythrocyte differentiation GO:0030218 62 31 1,000 0,01254215 0,07455101 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01254215 0,07437006 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01254215 0,07418999 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 0,01254215 0,07401079 ! amine biosynthetic process GO:0009309 146 88 2,000 0,01268313 0,07466238 ! tube morphogenesis GO:0035239 194 89 2,000 0,01307356 0,07677574 ! collagen metabolic process GO:0032963 49 32 1,000 0,01333047 0,07809676 ! spindle organization GO:0007051 50 32 1,000 0,01333047 0,07790993 ! metanephros development GO:0001656 81 32 1,000 0,01333047 0,07772399 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,01333047 0,07753893 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01333047 0,07735475 ! myeloid leukocyte activation GO:0002274 53 32 1,000 0,01333047 0,07717145 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01333047 0,07698901 ! response to inorganic substance GO:0010035 173 90 2,000 0,0134708 0,07761598 ! cholesterol homeostasis GO:0042632 60 33 1,000 0,01413981 0,08127895 GO:0055092|sterol homeostasis, ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,01413981 0,08108816 ! regulation of axonogenesis GO:0050770 86 33 1,000 0,01413981 0,08089826 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,01413981 0,08070924 ! establishment of vesicle localization GO:0051650 67 33 1,000 0,01413981 0,08052111 ! regulation of cell adhesion GO:0030155 241 92 2,000 0,01428579 0,08116323 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 0,01470356 0,08334293 ! glial cell differentiation GO:0010001 67 34 1,000 0,0149699 0,08465617 ! post-embryonic development GO:0009791 76 34 1,000 0,0149699 0,08446066 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,0149699 0,08426605 ! cholesterol transport GO:0030301 62 34 1,000 0,0149699 0,08407234 ! sterol metabolic process GO:0016125 166 94 2,000 0,0151282 0,08476651 ! positive regulation of endocytosis GO:0045807 56 35 1,000 0,0158205 0,08844273 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,0158205 0,08824081 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 0,0158205 0,0880398 ! telencephalon development GO:0021537 81 35 1,000 0,0158205 0,08783971 ! sterol transport GO:0015918 63 35 1,000 0,0158205 0,08764053 ! placenta development GO:0001890 53 35 1,000 0,0158205 0,08744225 ! vesicle localization GO:0051648 70 35 1,000 0,0158205 0,08724486 ! sex differentiation GO:0007548 171 96 2,000 0,01599814 0,0880258 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 0,01644346 0,09027273 ! regulation of muscle development GO:0048634 82 36 1,000 0,01669135 0,09142819 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01669135 0,09122365 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 1,000 0,01669135 0,09102003 ! embryonic organ development GO:0048568 67 36 1,000 0,01669135 0,09081731 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,01758222 0,09545191 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,01758222 0,09524027 ! sister chromatid segregation GO:0000819 65 37 1,000 0,01758222 0,09502956 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,01758222 0,09481978 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,01758222 0,09461093 ! negative regulation of cell activation GO:0050866 69 37 1,000 0,01758222 0,09440299 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01782092 0,09547477 GO:0060538|skeletal muscle organ development, ! spermatid development GO:0007286 69 38 1,000 0,01849286 0,09885787 ! neural tube formation GO:0001841 79 38 1,000 0,01849286 0,09864203 ! regulation of neuron projection development GO:0010975 102 39 1,000 0,01942302 0,10337787 ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,01942302 0,10315313 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,01942302 0,10292937 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,01942302 0,10270658 ! nucleus organization GO:0006997 73 40 1,000 0,02037248 0,10749451 ! lipid homeostasis GO:0055088 75 40 1,000 0,02037248 0,10726284 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,02037248 0,10703217 ! gliogenesis GO:0042063 91 41 1,000 0,02134098 0,11187986 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,02134098 0,11164029 ! mesenchymal cell development GO:0014031 94 41 1,000 0,02134098 0,11140174 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 95 41 1,000 0,02134098 0,11116421 ! spermatid differentiation GO:0048515 73 41 1,000 0,02134098 0,11092769 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,02134098 0,11069218 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,0223283 0,11556789 ! T cell differentiation GO:0030217 93 42 1,000 0,0223283 0,11532356 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,0223283 0,11508026 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02333421 0,12001151 GO:0090047|positive regulation of transcription regulator activity, ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,02333421 0,11975938 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,02333421 0,11950831 ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,02333421 0,1192583 ! segmentation GO:0035282 78 43 1,000 0,02333421 0,11900932 ! neuron migration GO:0001764 85 43 1,000 0,02333421 0,11876139 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,02435846 0,12371668 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 0,02435846 0,12346 ! heterocycle biosynthetic process GO:0018130 76 44 1,000 0,02435846 0,12320439 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,02540084 0,12821126 ! ATP synthesis coupled electron transport GO:0042773 69 45 1,000 0,02540084 0,12794691 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 1,000 0,02540084 0,12768364 ! biopolymer methylation GO:0043414 91 45 1,000 0,02540084 0,12742146 ! maintenance of location in cell GO:0051651 101 45 1,000 0,02540084 0,12716035 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,02646111 0,13219733 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,02646111 0,13192754 ! negative regulation of cell migration GO:0030336 122 46 1,000 0,02646111 0,13165885 ! pigmentation GO:0043473 103 46 1,000 0,02646111 0,13139125 ! cell growth GO:0016049 90 46 1,000 0,02646111 0,13112473 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,02646111 0,1308593 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02713297 0,13391079 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02713297 0,13364081 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02713297 0,13337191 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02713297 0,1331041 ! neuron fate determination GO:0048664 7 5 0,000 0,02713297 0,13283735 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02713297 0,13257168 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02713297 0,13230706 ! polyol transport GO:0015791 12 5 0,000 0,02713297 0,1320435 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02713297 0,13178099 ! response to superoxide GO:0000303 10 5 0,000 0,02713297 0,13151952 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02713297 0,13125909 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02713297 0,13099968 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02713297 0,1307413 ! female meiosis GO:0007143 10 5 0,000 0,02713297 0,13048394 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02713297 0,13022758 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02713297 0,12997223 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02713297 0,12971789 ! cobalt ion transport GO:0006824 11 5 0,000 0,02713297 0,12946453 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02713297 0,12921216 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02713297 0,12896078 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02713297 0,12871037 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02713297 0,12846093 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02713297 0,12821246 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02713297 0,12796494 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02713297 0,12771838 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02713297 0,12747277 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02713297 0,1272281 ! transposition GO:0032196 9 5 0,000 0,02713297 0,12698437 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02713297 0,12674157 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,02713297 0,12649969 ! negative chemotaxis GO:0050919 16 5 0,000 0,02713297 0,12625874 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02713297 0,12601871 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02713297 0,12577958 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02713297 0,12554136 ! behavioral response to pain GO:0048266 10 5 0,000 0,02713297 0,12530404 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02713297 0,12506762 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02713297 0,12483209 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02713297 0,12459744 ! micturition GO:0060073 9 5 0,000 0,02713297 0,12436368 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02713297 0,12413079 ! copulation GO:0007620 9 5 0,000 0,02713297 0,12389877 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02713297 0,12366761 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02713297 0,12343732 ! bioluminescence GO:0008218 9 5 0,000 0,02713297 0,12320788 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02713297 0,12297929 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02713297 0,12275155 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02713297 0,12252466 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02713297 0,1222986 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02713297 0,12207337 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02713297 0,12184897 ! grooming behavior GO:0007625 6 5 0,000 0,02713297 0,12162539 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02713297 0,12140264 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02713297 0,12118069 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02713297 0,12095956 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02713297 0,12073923 ! response to protozoan GO:0001562 13 5 0,000 0,02713297 0,12051971 ! lymph vessel development GO:0001945 10 5 0,000 0,02713297 0,12030098 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02713297 0,12008304 ! endochondral ossification GO:0001958 17 5 0,000 0,02713297 0,11986589 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02713297 0,11964953 ! single strand break repair GO:0000012 8 5 0,000 0,02713297 0,11943394 ! parathyroid gland development GO:0060017 14 5 0,000 0,02713297 0,11921914 ! anagen GO:0042640 7 5 0,000 0,02713297 0,1190051 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02713297 0,11879183 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02713297 0,11857932 ! cytokine secretion GO:0050663 15 5 0,000 0,02713297 0,11836757 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02713297 0,11815658 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02713297 0,11794633 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02713297 0,11773684 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02713297 0,11752808 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02713297 0,11732007 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02713297 0,11711279 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02713297 0,11690624 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02713297 0,11670042 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02713297 0,11649532 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02713297 0,11629095 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02713297 0,11608728 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02713297 0,11588433 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02713297 0,11568209 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02713297 0,11548056 ! valine metabolic process GO:0006573 12 5 0,000 0,02713297 0,11527972 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02713297 0,11507958 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02713297 0,11488014 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02713297 0,11468138 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02713297 0,11448332 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02713297 0,11428593 ! polyol catabolic process GO:0046174 9 5 0,000 0,02713297 0,11408922 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02713297 0,11389319 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02713297 0,11369784 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02713297 0,11350315 ! muscle cell migration GO:0014812 8 5 0,000 0,02713297 0,11330913 ! mitochondrial fission GO:0000266 8 5 0,000 0,02713297 0,11311577 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02713297 0,11292307 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02713297 0,11273102 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02713297 0,11253963 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02713297 0,11234888 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02713297 0,11215878 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02713297 0,11196932 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02713297 0,1117805 ! monocyte activation GO:0042117 10 5 0,000 0,02713297 0,11159232 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02713297 0,11140477 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02713297 0,11121785 ! response to food GO:0032094 6 5 0,000 0,02713297 0,11103156 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02713297 0,11084589 ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02713297 0,11066083 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02713297 0,1104764 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,02713297 0,11029258 ! forebrain neuron development GO:0021884 13 5 0,000 0,02713297 0,11010937 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02713297 0,10992677 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02713297 0,10974477 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02713297 0,10956337 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02713297 0,10938257 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02713297 0,10920237 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02713297 0,10902276 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02713297 0,10884374 ! lipid glycosylation GO:0030259 7 5 0,000 0,02713297 0,10866531 ! nucleobase transport GO:0015851 6 5 0,000 0,02713297 0,10848746 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02713297 0,1083102 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02713297 0,10813351 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02713297 0,10795739 ! basic amino acid transport GO:0015802 12 5 0,000 0,02713297 0,10778185 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02713297 0,10760688 ! actin nucleation GO:0045010 11 5 0,000 0,02713297 0,10743248 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02713297 0,10725864 ! depurination GO:0045007 5 5 0,000 0,02713297 0,10708536 ! depyrimidination GO:0045008 10 5 0,000 0,02713297 0,10691264 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02713297 0,10674048 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02713297 0,10656887 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02713297 0,10639782 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02713297 0,10622731 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02713297 0,10605734 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02713297 0,10588792 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02713297 0,10571904 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02713297 0,1055507 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02713297 0,10538289 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02713297 0,10521562 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02713297 0,10504887 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02713297 0,10488266 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02713297 0,10471697 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02713297 0,1045518 ! response to arsenic GO:0046685 11 5 0,000 0,02713297 0,10438715 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02713297 0,10422302 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02713297 0,1040594 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02713297 0,1038963 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02713297 0,10373371 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02713297 0,10357162 ! response to mercury ion GO:0046689 8 5 0,000 0,02713297 0,10341005 ! response to cadmium ion GO:0046686 7 5 0,000 0,02713297 0,10324897 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02713297 0,1030884 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02713297 0,10292832 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02713297 0,10276874 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02713297 0,10260966 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02713297 0,10245107 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02713297 0,10229296 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02713297 0,10213535 ! decidualization GO:0046697 11 5 0,000 0,02713297 0,10197821 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02713297 0,10182157 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02713297 0,1016654 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02713297 0,10150971 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02713297 0,10135449 ! embryonic cleavage GO:0040016 6 5 0,000 0,02713297 0,10119975 ! peroxisome fission GO:0016559 5 5 0,000 0,02713297 0,10104549 ! histone demethylation GO:0016577 13 5 0,000 0,02713297 0,10089169 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02713297 0,10073836 ! mitotic recombination GO:0006312 9 5 0,000 0,02713297 0,10058549 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02713297 0,10043309 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02713297 0,10028115 ! metaphase plate congression GO:0051310 7 5 0,000 0,02713297 0,10012967 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02713297 0,09997864 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02713297 0,09982807 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02713297 0,09967795 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02713297 0,09952829 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02713297 0,09937907 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02713297 0,0992303 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02713297 0,09908197 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02713297 0,09893409 ! B cell homeostasis GO:0001782 13 5 0,000 0,02713297 0,09878665 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02713297 0,09863964 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02713297 0,09849307 ! metaphase GO:0051323 11 5 0,000 0,02713297 0,09834694 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02713297 0,09820124 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02713297 0,09805598 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02713297 0,09791114 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02713297 0,09776672 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02713297 0,09762274 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02713297 0,09747918 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02713297 0,09733603 ! response to redox state GO:0051775 6 5 0,000 0,02713297 0,09719331 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02713297 0,09705101 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02713297 0,09690912 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02713297 0,09676765 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02713297 0,09662659 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02713297 0,09648594 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02713297 0,0963457 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02713297 0,09620586 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02713297 0,09606643 ! striatum development GO:0021756 14 5 0,000 0,02713297 0,09592741 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02713297 0,09578879 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02713297 0,09565056 ! glial cell migration GO:0008347 10 5 0,000 0,02713297 0,09551274 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02713297 0,09537531 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02713297 0,09523828 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02713297 0,09510163 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02713297 0,09496539 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02713297 0,09482953 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02713297 0,09469406 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02713297 0,09455897 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02713297 0,09442427 ! neuroprotection GO:0043526 8 5 0,000 0,02713297 0,09428996 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02713297 0,09415602 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02713297 0,09402247 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02713297 0,09388929 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02713297 0,09375649 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02713297 0,09362407 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02713297 0,09349202 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02713297 0,09336034 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02713297 0,09322903 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02713297 0,09309809 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,02713297 0,09296752 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02713297 0,09283731 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02713297 0,09270747 ! spindle assembly GO:0051225 6 5 0,000 0,02713297 0,09257799 ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02713297 0,09244887 ! protein palmitoylation GO:0018345 12 5 0,000 0,02713297 0,09232011 ! drug metabolic process GO:0017144 7 5 0,000 0,02713297 0,09219171 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02713297 0,09206367 ! organ regeneration GO:0031100 7 5 0,000 0,02713297 0,09193598 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02713297 0,09180864 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02713297 0,09168166 ! neural tube development GO:0021915 91 47 1,000 0,02753905 0,09292528 ! positive regulation of defense response GO:0031349 88 48 1,000 0,02863444 0,09648818 ! endosome transport GO:0016197 127 48 1,000 0,02863444 0,09635527 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,02863444 0,09622274 ! male sex differentiation GO:0046661 93 48 1,000 0,02863444 0,09609056 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,02863444 0,09595875 ! regulation of inflammatory response GO:0050727 84 48 1,000 0,02863444 0,0958273 ! methylation GO:0032259 97 48 1,000 0,02863444 0,09569621 ! response to calcium ion GO:0051592 94 49 1,000 0,02974705 0,09927874 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,02974705 0,09914329 ! regulation of action potential GO:0001508 102 50 1,000 0,03087666 0,10276795 ! endocrine system development GO:0035270 109 50 1,000 0,03087666 0,10262813 ! activation of caspase activity GO:0006919 95 50 1,000 0,03087666 0,10248869 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,03087666 0,10234963 ! epidermal cell differentiation GO:0009913 87 50 1,000 0,03087666 0,10221095 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,03087666 0,10207264 ! viral infectious cycle GO:0019058 104 51 1,000 0,03202306 0,10571937 ! response to temperature stimulus GO:0009266 84 51 1,000 0,03202306 0,10557669 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,03202306 0,10543441 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03247102 0,10676541 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03247102 0,10662191 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03247102 0,1064788 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03247102 0,10633606 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03247102 0,10619371 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03247102 0,10605174 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03247102 0,10591015 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03247102 0,10576894 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03247102 0,1056281 ! response to oxygen radical GO:0000305 11 6 0,000 0,03247102 0,10548764 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03247102 0,10534755 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03247102 0,10520783 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03247102 0,10506848 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03247102 0,1049295 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03247102 0,10479089 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03247102 0,10465264 ! forebrain regionalization GO:0021871 9 6 0,000 0,03247102 0,10451476 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03247102 0,10437724 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03247102 0,10424008 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03247102 0,10410329 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03247102 0,10396685 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03247102 0,10383076 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03247102 0,10369504 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03247102 0,10355966 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03247102 0,10342465 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03247102 0,10328998 ! malate metabolic process GO:0006108 13 6 0,000 0,03247102 0,10315566 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03247102 0,10302169 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03247102 0,10288807 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03247102 0,1027548 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03247102 0,10262187 ! protein refolding GO:0042026 15 6 0,000 0,03247102 0,10248928 ! opsonization GO:0008228 8 6 0,000 0,03247102 0,10235704 ! mating behavior GO:0007617 7 6 0,000 0,03247102 0,10222513 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03247102 0,10209357 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03247102 0,10196234 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03247102 0,10183145 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03247102 0,1017009 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03247102 0,10157068 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03247102 0,1014408 ! toxin metabolic process GO:0009404 11 6 0,000 0,03247102 0,10131124 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03247102 0,10118202 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03247102 0,10105313 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03247102 0,10092456 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03247102 0,10079632 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03247102 0,10066841 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03247102 0,10054082 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03247102 0,10041355 ! thymic T cell selection GO:0045061 16 6 0,000 0,03247102 0,1002866 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03247102 0,10015998 ! protein lipoylation GO:0009249 10 6 0,000 0,03247102 0,10003367 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03247102 0,09990769 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03247102 0,09978202 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03247102 0,09965666 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03247102 0,09953162 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03247102 0,0994069 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03247102 0,09928248 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03247102 0,09915838 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03247102 0,09903459 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03247102 0,0989111 ! hyperosmotic response GO:0006972 10 6 0,000 0,03247102 0,09878792 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03247102 0,09866505 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03247102 0,09854249 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03247102 0,09842023 ! urea metabolic process GO:0019627 7 6 0,000 0,03247102 0,09829827 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03247102 0,09817661 ! neutrophil activation GO:0042119 7 6 0,000 0,03247102 0,09805526 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03247102 0,0979342 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03247102 0,09781344 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03247102 0,09769298 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03247102 0,09757282 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03247102 0,09745295 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03247102 0,09733338 ! neuron apoptosis GO:0051402 15 6 0,000 0,03247102 0,0972141 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03247102 0,09709511 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03247102 0,09697641 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03247102 0,096858 ! carnitine transport GO:0015879 10 6 0,000 0,03247102 0,09673988 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03247102 0,09662205 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03247102 0,09650451 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03247102 0,09638725 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03247102 0,09627027 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03247102 0,09615358 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03247102 0,09603717 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03247102 0,09592104 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03247102 0,0958052 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03247102 0,09568963 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,03247102 0,09557434 ! response to UV-C GO:0010225 14 6 0,000 0,03247102 0,09545933 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03247102 0,0953446 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03247102 0,09523014 ! interaction with symbiont GO:0051702 14 6 0,000 0,03247102 0,09511595 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03247102 0,09500204 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03247102 0,0948884 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03247102 0,09477503 ! response to copper ion GO:0046688 10 6 0,000 0,03247102 0,09466194 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03247102 0,09454911 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03247102 0,09443655 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03247102 0,09432426 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03247102 0,09421224 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03247102 0,09410048 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03247102 0,09398898 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03247102 0,09387776 ! hair follicle maturation GO:0048820 8 6 0,000 0,03247102 0,09376679 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03247102 0,09365608 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03247102 0,09354564 ! response to pheromone GO:0019236 6 6 0,000 0,03247102 0,09343546 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03247102 0,09332553 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03247102 0,09321587 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,03247102 0,09310646 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03247102 0,09299731 ! subpallium development GO:0021544 15 6 0,000 0,03247102 0,09288841 ! neural tube patterning GO:0021532 8 6 0,000 0,03247102 0,09277977 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03247102 0,09267138 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03247102 0,09256325 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03247102 0,09245537 ! G2 phase GO:0051319 16 6 0,000 0,03247102 0,09234773 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03247102 0,09224035 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03247102 0,09213322 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03247102 0,09202634 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03247102 0,0919197 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03247102 0,09181331 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03247102 0,09170717 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03247102 0,09160127 ! receptor internalization GO:0031623 11 6 0,000 0,03247102 0,09149562 ! plasminogen activation GO:0031639 9 6 0,000 0,03247102 0,09139021 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03247102 0,09128504 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03247102 0,09118012 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03247102 0,09107543 ! protein deubiquitination GO:0016579 16 6 0,000 0,03247102 0,09097099 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03247102 0,09086678 ! protein destabilization GO:0031648 9 6 0,000 0,03247102 0,09076282 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03247102 0,09065909 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03247102 0,0905556 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03247102 0,09045234 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03247102 0,09034932 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03247102 0,09024653 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03247102 0,09014398 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03247102 0,09004166 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03247102 0,08993957 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03247102 0,08983772 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03247102 0,08973609 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03247102 0,08963469 ! neural plate development GO:0001840 9 6 0,000 0,03247102 0,08953353 ! catecholamine transport GO:0051937 9 6 0,000 0,03247102 0,08943259 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03247102 0,08933187 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03247102 0,08923139 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03247102 0,08913113 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03247102 0,08903109 ! maternal placenta development GO:0001893 12 6 0,000 0,03247102 0,08893128 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03247102 0,08883169 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03247102 0,08873233 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03247102 0,08863319 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03247102 0,08853427 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03247102 0,08843557 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03247102 0,08833709 GO:0055081|anion homeostasis, ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,03318603 0,09018183 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,03318603 0,09008162 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,03318603 0,08998164 ! excretion GO:0007588 87 52 1,000 0,03318603 0,08988189 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,03318603 0,08978235 ! histone modification GO:0016570 104 52 1,000 0,03318603 0,08968303 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,03318603 0,08958394 ! respiratory electron transport chain GO:0022904 83 53 1,000 0,03436535 0,09266506 ! positive regulation of growth GO:0045927 96 53 1,000 0,03436535 0,0925629 ! cartilage development GO:0051216 99 53 1,000 0,03436535 0,09246096 ! synapse organization GO:0050808 102 53 1,000 0,03436535 0,09235924 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,03556082 0,09546711 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,03556082 0,09536232 ! covalent chromatin modification GO:0016569 115 54 1,000 0,03556082 0,09525776 ! regulation of cell shape GO:0008360 142 54 1,000 0,03556082 0,09515342 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,03556082 0,09504931 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,03677221 0,0981798 ! cell recognition GO:0008037 98 55 1,000 0,03677221 0,09807262 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,03677221 0,09796567 ! cell maturation GO:0048469 107 55 1,000 0,03677221 0,09785895 ! tRNA transcription GO:0009304 17 7 0,000 0,03777993 0,10043131 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03777993 0,10032215 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03777993 0,10021322 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03777993 0,10010453 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03777993 0,09999608 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03777993 0,09988785 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03777993 0,09977987 ! sleep GO:0030431 16 7 0,000 0,03777993 0,09967211 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03777993 0,09956459 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03777993 0,0994573 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03777993 0,09935025 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03777993 0,09924342 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03777993 0,09913682 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03777993 0,09903045 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03777993 0,09892431 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03777993 0,09881839 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03777993 0,0987127 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03777993 0,09860724 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03777993 0,098502 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03777993 0,09839699 ! glycolipid transport GO:0046836 11 7 0,000 0,03777993 0,0982922 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03777993 0,09818764 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,03777993 0,09808329 ! neuron adhesion GO:0007158 14 7 0,000 0,03777993 0,09797917 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03777993 0,09787527 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03777993 0,09777159 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03777993 0,09766812 ! pericardium development GO:0060039 16 7 0,000 0,03777993 0,09756488 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,03777993 0,09746186 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,03777993 0,09735905 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,03777993 0,09725646 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03777993 0,09715408 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03777993 0,09705192 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03777993 0,09694998 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03777993 0,09684825 ! rhythmic behavior GO:0007622 17 7 0,000 0,03777993 0,09674673 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03777993 0,09664542 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03777993 0,09654433 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03777993 0,09644345 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03777993 0,09634277 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03777993 0,09624231 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03777993 0,09614206 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03777993 0,09604202 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03777993 0,09594218 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03777993 0,09584255 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,03777993 0,09574313 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03777993 0,09564391 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03777993 0,0955449 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03777993 0,0954461 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03777993 0,0953475 ! spinal cord patterning GO:0021511 14 7 0,000 0,03777993 0,0952491 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03777993 0,0951509 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03777993 0,09505291 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03777993 0,09495512 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03777993 0,09485753 ! adrenal gland development GO:0030325 17 7 0,000 0,03777993 0,09476014 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03777993 0,09466295 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03777993 0,09456596 ! ovulation GO:0030728 10 7 0,000 0,03777993 0,09446917 ! adenohypophysis development GO:0021984 11 7 0,000 0,03777993 0,09437257 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03777993 0,09427618 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03777993 0,09417998 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03777993 0,09408397 ! microtubule nucleation GO:0007020 21 7 0,000 0,03777993 0,09398816 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03777993 0,09389255 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03777993 0,09379713 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03777993 0,09370191 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03777993 0,09360687 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03777993 0,09351203 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03777993 0,09341739 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03777993 0,09332293 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03777993 0,09322866 ! galactose metabolic process GO:0006012 13 7 0,000 0,03777993 0,09313459 ! vesicle fusion GO:0006906 20 7 0,000 0,03777993 0,0930407 ! response to dietary excess GO:0002021 8 7 0,000 0,03777993 0,09294701 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03777993 0,0928535 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03777993 0,09276018 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,03777993 0,09266705 ! organ growth GO:0035265 15 7 0,000 0,03777993 0,0925741 ! nucleoside transport GO:0015858 11 7 0,000 0,03777993 0,09248134 ! nucleoside salvage GO:0043174 11 7 0,000 0,03777993 0,09238877 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03777993 0,09229638 ! male sex determination GO:0030238 15 7 0,000 0,03777993 0,09220417 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03777993 0,09211215 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03777993 0,09202032 ! parturition GO:0007567 16 7 0,000 0,03777993 0,09192866 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03777993 0,09183719 ! rRNA modification GO:0000154 14 7 0,000 0,03777993 0,0917459 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03777993 0,09165479 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03777993 0,09156387 ! monocyte differentiation GO:0030224 16 7 0,000 0,03777993 0,09147312 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03777993 0,09138255 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03777993 0,09129216 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03777993 0,09120195 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03777993 0,09111192 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03777993 0,09102207 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03777993 0,09093239 ! fibrinolysis GO:0042730 11 7 0,000 0,03777993 0,09084289 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,03777993 0,09075357 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03777993 0,09066442 ! eating behavior GO:0042755 8 7 0,000 0,03777993 0,09057544 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03777993 0,09048664 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03777993 0,09039802 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03777993 0,09030957 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03777993 0,09022129 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03777993 0,09013318 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03777993 0,09004525 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03777993 0,08995748 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03777993 0,08986989 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03777993 0,08978247 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03777993 0,08969522 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03777993 0,08960813 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03777993 0,08952122 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03777993 0,08943447 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03777993 0,0893479 ! histone ubiquitination GO:0016574 9 7 0,000 0,03777993 0,08926149 ! regulation of meiosis GO:0040020 12 7 0,000 0,03777993 0,08917524 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03777993 0,08908917 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03777993 0,08900326 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,03777993 0,08891751 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03777993 0,08883193 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03777993 0,08874652 ! transcription termination GO:0006353 14 7 0,000 0,03777993 0,08866127 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03777993 0,08857618 ! anaphase GO:0051322 18 7 0,000 0,03777993 0,08849125 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03777993 0,08840649 ! axonal fasciculation GO:0007413 19 7 0,000 0,03777993 0,08832189 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03777993 0,08823745 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03777993 0,08815318 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03777993 0,08806906 ! diuresis GO:0030146 12 7 0,000 0,03777993 0,08798511 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03777993 0,08790131 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03777993 0,08781768 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03777993 0,0877342 ! antibiotic transport GO:0042891 9 7 0,000 0,03777993 0,08765088 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03777993 0,08756772 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,03777993 0,08748472 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03777993 0,08740187 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03777993 0,08731918 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03777993 0,08723665 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03777993 0,08715428 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03777993 0,08707205 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03777993 0,08698999 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03777993 0,08690808 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03777993 0,08682632 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,03777993 0,08674472 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03777993 0,08666327 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03777993 0,08658197 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03777993 0,08650082 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03777993 0,08641983 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03777993 0,08633899 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03777993 0,0862583 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03777993 0,08617776 ! muscle adaptation GO:0043500 13 7 0,000 0,03777993 0,08609737 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03777993 0,08601713 ! retina homeostasis GO:0001895 12 7 0,000 0,03777993 0,08593704 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03777993 0,0858571 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03777993 0,0857773 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03777993 0,08569766 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,03777993 0,08561816 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,03799934 0,08603557 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,03799934 0,08595591 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,03799934 0,08587639 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,03924197 0,08860272 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,03924197 0,08852091 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,03924197 0,08843925 ! heart morphogenesis GO:0003007 105 57 1,000 0,03924197 0,08835773 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,03924197 0,08827637 ! regulation of actin filament length GO:0030832 118 58 1,000 0,04049992 0,09102237 ! lipoprotein biosynthetic process GO:0042158 115 58 1,000 0,04049992 0,09093871 ! aging GO:0007568 112 58 1,000 0,04049992 0,0908552 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,04049992 0,09077185 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,04049992 0,09068865 ! maintenance of location GO:0051235 124 58 1,000 0,04049992 0,0906056 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04305986 0,09624451 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04305986 0,09615654 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,04305986 0,09606872 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04305986 0,09598107 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04305986 0,09589357 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04305986 0,09580624 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04305986 0,09571906 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04305986 0,09563205 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04305986 0,09554519 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04305986 0,09545848 ! meiotic prophase I GO:0007128 14 8 0,000 0,04305986 0,09537194 ! response to zinc ion GO:0010043 12 8 0,000 0,04305986 0,09528555 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04305986 0,09519932 ! oligopeptide transport GO:0006857 16 8 0,000 0,04305986 0,09511325 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04305986 0,09502733 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04305986 0,09494156 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04305986 0,09485595 ! signal peptide processing GO:0006465 12 8 0,000 0,04305986 0,0947705 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04305986 0,09468519 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04305986 0,09460004 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04305986 0,09451505 ! succinate metabolic process GO:0006105 17 8 0,000 0,04305986 0,09443021 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04305986 0,09434552 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04305986 0,09426098 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,04305986 0,09417659 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04305986 0,09409235 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04305986 0,09400827 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04305986 0,09392433 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04305986 0,09384054 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04305986 0,09375691 ! reflex GO:0060004 17 8 0,000 0,04305986 0,09367342 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04305986 0,09359008 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04305986 0,09350689 ! pigment granule organization GO:0048753 17 8 0,000 0,04305986 0,09342385 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04305986 0,09334095 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04305986 0,0932582 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04305986 0,0931756 ! histidine catabolic process GO:0006548 10 8 0,000 0,04305986 0,09309314 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04305986 0,09301083 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04305986 0,09292867 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04305986 0,09284665 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,04305986 0,09276477 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04305986 0,09268304 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,04305986 0,09260145 ! melanin metabolic process GO:0006582 17 8 0,000 0,04305986 0,09252001 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04305986 0,09243871 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04305986 0,09235755 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04305986 0,09227653 ! macrophage activation GO:0042116 13 8 0,000 0,04305986 0,09219566 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04305986 0,09211493 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04305986 0,09203434 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04305986 0,09195389 ! purine salvage GO:0043101 12 8 0,000 0,04305986 0,09187358 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04305986 0,09179341 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04305986 0,09171338 ! osteoblast development GO:0002076 17 8 0,000 0,04305986 0,09163349 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04305986 0,09155374 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04305986 0,09147413 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04305986 0,09139466 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04305986 0,09131532 ! response to UV-B GO:0010224 17 8 0,000 0,04305986 0,09123612 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04305986 0,09115706 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04305986 0,09107814 ! intermediate filament organization GO:0045109 12 8 0,000 0,04305986 0,09099935 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04305986 0,0909207 ! cellular extravasation GO:0045123 13 8 0,000 0,04305986 0,09084218 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04305986 0,0907638 ! response to antibiotic GO:0046677 11 8 0,000 0,04305986 0,09068556 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04305986 0,09060745 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04305986 0,09052947 ! DNA topological change GO:0006265 12 8 0,000 0,04305986 0,09045163 ! response to tropane GO:0014073 15 8 0,000 0,04305986 0,09037393 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04305986 0,09029635 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04305986 0,09021891 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04305986 0,0901416 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04305986 0,09006443 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04305986 0,08998738 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04305986 0,08991047 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04305986 0,08983369 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04305986 0,08975704 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04305986 0,08968052 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04305986 0,08960413 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04305986 0,08952787 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04305986 0,08945174 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04305986 0,08937574 ! response to tumor cell GO:0002347 16 8 0,000 0,04305986 0,08929987 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04305986 0,08922413 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04305986 0,08914852 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04305986 0,08907303 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04305986 0,08899767 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04305986 0,08892244 ! hormone catabolic process GO:0042447 17 8 0,000 0,04305986 0,08884734 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04305986 0,08877236 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04305986 0,08869751 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04305986 0,08862279 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04305986 0,08854819 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04305986 0,08847372 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04305986 0,08839937 ! adult feeding behavior GO:0008343 10 8 0,000 0,04305986 0,08832515 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04305986 0,08825105 ! ATP catabolic process GO:0006200 11 8 0,000 0,04305986 0,08817707 ! blastocyst growth GO:0001832 19 8 0,000 0,04305986 0,08810322 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04305986 0,0880295 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04305986 0,08795589 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04305986 0,08788241 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04305986 0,08780906 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04305986 0,08773582 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04305986 0,08766271 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04305986 0,08758972 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04305986 0,08751685 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04305986 0,0874441 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04305986 0,08737147 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04305986 0,08729896 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04305986 0,08722658 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04305986 0,08715431 ! protein prenylation GO:0018342 21 8 0,000 0,04305986 0,08708216 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04305986 0,08701013 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04305986 0,08693822 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04305986 0,08686643 ! regulation of neurotransmitter levels GO:0001505 113 60 1,000 0,04306094 0,08679693 ! lipid modification GO:0030258 112 60 1,000 0,04306094 0,08672538 ! DNA catabolic process GO:0006308 94 60 1,000 0,04306094 0,08665394 ! regulation of endocytosis GO:0030100 104 60 1,000 0,04306094 0,08658262 ! kidney development GO:0001822 133 60 1,000 0,04306094 0,08651142 ! positive regulation of secretion GO:0051047 110 61 1,000 0,04436361 0,0890553 ! regulation of cellular component size GO:0032535 125 61 1,000 0,04436361 0,08898218 ! regulation of Rab protein signal transduction GO:0032483 109 61 1,000 0,04436361 0,08890919 GO:0032313|regulation of Rab GTPase activity, ! camera-type eye development GO:0043010 126 61 1,000 0,04436361 0,08883631 ! viral reproductive process GO:0022415 132 62 1,000 0,04568079 0,09139899 ! axon extension GO:0048675 16 9 0,000 0,04831097 0,09658241 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04831097 0,09650344 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04831097 0,09642459 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04831097 0,09634588 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,04831097 0,09626729 ! reproductive behavior GO:0019098 22 9 0,000 0,04831097 0,09618884 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04831097 0,09611051 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,04831097 0,09603231 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04831097 0,09595423 ! RNA methylation GO:0001510 16 9 0,000 0,04831097 0,09587628 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04831097 0,09579846 ! regulation of histone modification GO:0031056 14 9 0,000 0,04831097 0,09572076 ! equilibrioception GO:0050957 20 9 0,000 0,04831097 0,0956432 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,04831097 0,09556575 ! chemosensory behavior GO:0007635 21 9 0,000 0,04831097 0,09548843 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,04831097 0,09541124 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04831097 0,09533417 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,04831097 0,09525723 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04831097 0,09518041 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04831097 0,09510371 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,04831097 0,09502714 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04831097 0,09495069 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04831097 0,09487436 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04831097 0,09479816 ! protein targeting to ER GO:0045047 25 9 0,000 0,04831097 0,09472207 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04831097 0,09464611 ! T cell selection GO:0045058 27 9 0,000 0,04831097 0,09457027 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,04831097 0,09449456 ! glycine catabolic process GO:0006546 15 9 0,000 0,04831097 0,09441896 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04831097 0,09434349 ! endosome organization GO:0007032 20 9 0,000 0,04831097 0,09426813 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04831097 0,0941929 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04831097 0,09411779 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04831097 0,09404279 ! mannose metabolic process GO:0006013 13 9 0,000 0,04831097 0,09396792 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04831097 0,09389316 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04831097 0,09381852 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,04831097 0,09374401 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04831097 0,09366961 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04831097 0,09359532 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04831097 0,09352116 ! retinol metabolic process GO:0042572 20 9 0,000 0,04831097 0,09344711 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04831097 0,09337318 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04831097 0,09329937 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,04831097 0,09322567 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04831097 0,09315209 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04831097 0,09307863 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04831097 0,09300528 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04831097 0,09293205 ! response to amine stimulus GO:0014075 13 9 0,000 0,04831097 0,09285893 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04831097 0,09278593 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04831097 0,09271304 ! erythrocyte development GO:0048821 17 9 0,000 0,04831097 0,09264027 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04831097 0,09256761 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,04831097 0,09249507 ! renal water homeostasis GO:0003091 15 9 0,000 0,04831097 0,09242263 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04831097 0,09235032 ! icosanoid secretion GO:0032309 15 9 0,000 0,04831097 0,09227811 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04831097 0,09220602 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,04831097 0,09213404 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04831097 0,09206217 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04831097 0,09199042 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04831097 0,09191877 ! sterol catabolic process GO:0016127 14 9 0,000 0,04831097 0,09184724 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04831097 0,09177582 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04831097 0,09170451 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,04831097 0,09163331 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,04831097 0,09156222 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,04831097 0,09149124 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,04831097 0,09142037 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,04831097 0,09134962 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04831097 0,09127897 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04831097 0,09120843 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04831097 0,09113799 ! purine base metabolic process GO:0006144 25 9 0,000 0,04831097 0,09106767 ! pigment granule transport GO:0051904 17 9 0,000 0,04831097 0,09099746 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,04831097 0,09092735 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,04831097 0,09085735 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04831097 0,09078746 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04831097 0,09071768 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04831097 0,09064801 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,04831097 0,09057844 ! mitochondrion localization GO:0051646 18 9 0,000 0,04831097 0,09050897 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,04835788 0,09052743 ! gonad development GO:0008406 115 66 1,000 0,05109066 0,09557005 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,05353341 0,10006283 ! regulation of developmental growth GO:0048638 16 10 0,000 0,05353341 0,09998633 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05353341 0,09990995 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05353341 0,09983368 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05353341 0,09975753 ! associative learning GO:0008306 21 10 0,000 0,05353341 0,09968149 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05353341 0,09960558 ! phosphate transport GO:0006817 24 10 0,000 0,05353341 0,09952977 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05353341 0,09945408 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,05353341 0,09937851 ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,05353341 0,09930305 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,05353341 0,09922771 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05353341 0,09915248 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05353341 0,09907736 ! social behavior GO:0035176 29 10 0,000 0,05353341 0,09900236 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,05353341 0,09892747 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,05353341 0,0988527 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,05353341 0,09877804 ! androgen metabolic process GO:0008209 17 10 0,000 0,05353341 0,09870349 ! phospholipid efflux GO:0033700 19 10 0,000 0,05353341 0,09862905 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05353341 0,09855473 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05353341 0,09848051 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,05353341 0,09840641 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,05353341 0,09833242 ! pathogenesis GO:0009405 17 10 0,000 0,05353341 0,09825854 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05353341 0,09818478 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05353341 0,09811112 ! endoderm development GO:0007492 18 10 0,000 0,05353341 0,09803757 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,05353341 0,09796414 ! arginine catabolic process GO:0006527 17 10 0,000 0,05353341 0,09789081 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05353341 0,09781759 ! proline metabolic process GO:0006560 13 10 0,000 0,05353341 0,09774449 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05353341 0,09767149 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,05353341 0,0975986 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05353341 0,09752582 ! V(D)J recombination GO:0033151 34 10 0,000 0,05353341 0,09745315 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05353341 0,09738058 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,05353341 0,09730813 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05353341 0,09723578 ! B cell proliferation GO:0042100 19 10 0,000 0,05353341 0,09716354 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,05353341 0,0970914 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05353341 0,09701938 ! multicellular organism growth GO:0035264 19 10 0,000 0,05353341 0,09694746 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05353341 0,09687565 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,05353341 0,09680394 ! ruffle organization GO:0031529 17 10 0,000 0,05353341 0,09673234 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05353341 0,09666084 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05353341 0,09658945 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05353341 0,09651817 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05353341 0,09644699 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05353341 0,09637592 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,05353341 0,09630495 ! motor axon guidance GO:0008045 22 10 0,000 0,05353341 0,09623408 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05353341 0,09616332 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,05353341 0,09609267 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,05353341 0,09602212 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,05353341 0,09595167 ! segment specification GO:0007379 15 10 0,000 0,05353341 0,09588132 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,05353341 0,09581108 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,05353341 0,09574094 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05353341 0,0956709 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05353341 0,09560097 ! response to dsRNA GO:0043331 23 10 0,000 0,05353341 0,09553113 ! DNA ligation GO:0006266 18 10 0,000 0,05353341 0,0954614 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,05353341 0,09539177 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05353341 0,09532225 ! melanosome localization GO:0032400 16 10 0,000 0,05353341 0,09525282 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05353341 0,09518349 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,05353341 0,09511427 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05353341 0,09504515 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05353341 0,09497612 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,05353341 0,0949072 ! induction of an organ GO:0001759 17 10 0,000 0,05353341 0,09483838 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05353341 0,09476965 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05353341 0,09470103 ! protein sumoylation GO:0016925 17 10 0,000 0,05353341 0,0946325 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,05353341 0,09456408 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05353341 0,09449575 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05353341 0,09442752 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05353341 0,09435939 ! salivary gland development GO:0007431 28 10 0,000 0,05353341 0,09429136 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05353341 0,09422343 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,05353341 0,09415559 ! midbrain development GO:0030901 14 10 0,000 0,05353341 0,09408786 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05353341 0,09402022 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,05353341 0,09395267 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05353341 0,09388523 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,05353341 0,09381788 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05353341 0,09375062 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05353341 0,09368347 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05353341 0,09361641 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05353341 0,09354944 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,05353341 0,09348257 ! detection of calcium ion GO:0005513 24 10 0,000 0,05353341 0,0934158 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05353341 0,09334912 ! blastocyst formation GO:0001825 18 10 0,000 0,05353341 0,09328254 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05353341 0,09321605 ! cerebellar cortex development GO:0021695 16 10 0,000 0,05353341 0,09314966 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,05353341 0,09308336 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,05353341 0,09301716 ! response to nicotine GO:0035094 20 10 0,000 0,05353341 0,09295105 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,05353341 0,09288503 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,05387761 0,0934159 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,05387761 0,09334965 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 142 68 1,000 0,05387761 0,09328349 ! adaptive immune response GO:0002250 126 68 1,000 0,05387761 0,09321742 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! homeostasis of number of cells GO:0048872 131 69 1,000 0,05529093 0,09559501 ! developmental maturation GO:0021700 128 69 1,000 0,05529093 0,0955274 ! activation of immune response GO:0002253 120 70 1,000 0,05671723 0,0979224 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,05815633 0,1003361 ! respiratory burst GO:0045730 17 11 0,000 0,05872734 0,10124974 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05872734 0,10117834 ! neuron fate specification GO:0048665 18 11 0,000 0,05872734 0,10110704 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,05872734 0,10103583 ! thyroid gland development GO:0030878 26 11 0,000 0,05872734 0,10096473 ! synapsis GO:0007129 14 11 0,000 0,05872734 0,10089373 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05872734 0,10082283 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05872734 0,10075202 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,05872734 0,10068132 ! response to pain GO:0048265 27 11 0,000 0,05872734 0,10061072 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,05872734 0,10054021 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05872734 0,10046981 ! bone resorption GO:0045453 16 11 0,000 0,05872734 0,1003995 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05872734 0,10032929 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05872734 0,10025918 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05872734 0,10018916 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05872734 0,10011925 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05872734 0,10004943 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05872734 0,09997971 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05872734 0,09991009 GO:0010833|telomere maintenance via telomere lengthening, ! regulation of intracellular pH GO:0051453 21 11 0,000 0,05872734 0,09984056 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05872734 0,09977113 ! UV protection GO:0009650 20 11 0,000 0,05872734 0,0997018 ! adult heart development GO:0007512 16 11 0,000 0,05872734 0,09963256 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,05872734 0,09956342 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05872734 0,09949437 ! macroautophagy GO:0016236 19 11 0,000 0,05872734 0,09942542 ! temperature homeostasis GO:0001659 18 11 0,000 0,05872734 0,09935657 ! behavioral fear response GO:0001662 27 11 0,000 0,05872734 0,09928781 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05872734 0,09921914 ! negative regulation of ossification GO:0030279 27 11 0,000 0,05872734 0,09915058 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05872734 0,0990821 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,05872734 0,09901372 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,05872734 0,09894544 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,05872734 0,09887725 ! regulation of organ growth GO:0046620 14 11 0,000 0,05872734 0,09880915 ! pigment granule localization GO:0051875 20 11 0,000 0,05872734 0,09874114 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,05872734 0,09867323 ! vasoconstriction GO:0042310 20 11 0,000 0,05872734 0,09860542 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05872734 0,09853769 ! embryonic axis specification GO:0000578 19 11 0,000 0,05872734 0,09847006 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05872734 0,09840253 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05872734 0,09833508 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05872734 0,09826773 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05872734 0,09820047 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05872734 0,0981333 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05872734 0,09806622 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05872734 0,09799924 ! prophase GO:0051324 17 11 0,000 0,05872734 0,09793234 ! neuroblast proliferation GO:0007405 25 11 0,000 0,05872734 0,09786554 ! nucleosome positioning GO:0016584 15 11 0,000 0,05872734 0,09779883 ! regulation of isotype switching GO:0045191 24 11 0,000 0,05872734 0,09773221 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05872734 0,09766568 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05872734 0,09759924 ! apical protein localization GO:0045176 18 11 0,000 0,05872734 0,09753289 ! acid secretion GO:0046717 20 11 0,000 0,05872734 0,09746663 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05872734 0,09740046 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05872734 0,09733438 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05872734 0,0972684 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,05872734 0,0972025 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05872734 0,09713668 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,05872734 0,09707096 ! cholesterol efflux GO:0033344 21 11 0,000 0,05872734 0,09700533 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05872734 0,09693979 ! oocyte development GO:0048599 20 11 0,000 0,05872734 0,09687433 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,05872734 0,09680896 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,05872734 0,09674368 ! embryonic gut development GO:0048566 19 11 0,000 0,05872734 0,09667849 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,05872734 0,09661339 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05872734 0,09654837 ! activation of innate immune response GO:0002218 16 11 0,000 0,05872734 0,09648345 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05872734 0,0964186 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05872734 0,09635385 ! lysogeny GO:0030069 22 11 0,000 0,05872734 0,09628918 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05872734 0,0962246 ! sequestering of metal ion GO:0051238 15 11 0,000 0,05872734 0,09616011 ! regulation of embryonic development GO:0045995 35 11 0,000 0,05872734 0,0960957 ! coenzyme biosynthetic process GO:0009108 119 72 1,000 0,05960805 0,09747153 ! regulation of caspase activity GO:0043281 136 74 1,000 0,06254861 0,10221155 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,06254861 0,10214322 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06389291 0,10426878 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06389291 0,10419918 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06389291 0,10412967 ! virus-host interaction GO:0019048 30 12 0,000 0,06389291 0,10406025 ! mating GO:0007618 17 12 0,000 0,06389291 0,10399092 ! protein complex disassembly GO:0043241 28 12 0,000 0,06389291 0,10392168 GO:0043624|cellular protein complex disassembly, ! hippocampus development GO:0021766 29 12 0,000 0,06389291 0,10385254 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06389291 0,10378349 ! T cell proliferation GO:0042098 32 12 0,000 0,06389291 0,10371453 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06389291 0,10364566 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06389291 0,10357689 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06389291 0,1035082 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06389291 0,10343961 ! drug transport GO:0015893 16 12 0,000 0,06389291 0,10337111 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06389291 0,10330269 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06389291 0,10323437 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06389291 0,10316614 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06389291 0,103098 ! focal adhesion formation GO:0048041 37 12 0,000 0,06389291 0,10302995 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06389291 0,10296198 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06389291 0,10289411 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06389291 0,10282633 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 21 12 0,000 0,06389291 0,10275864 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06389291 0,10269103 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06389291 0,10262352 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06389291 0,10255609 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06389291 0,10248875 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06389291 0,1024215 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06389291 0,10235434 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06389291 0,10228727 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06389291 0,10222028 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06389291 0,10215338 GO:0016180|snRNA processing, ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06389291 0,10208657 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06389291 0,10201985 ! cranial nerve development GO:0021545 23 12 0,000 0,06389291 0,10195321 ! fucose catabolic process GO:0019317 25 12 0,000 0,06389291 0,10188666 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06389291 0,1018202 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,06389291 0,10175383 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06389291 0,10168754 ! zymogen activation GO:0031638 18 12 0,000 0,06389291 0,10162133 ! T cell homeostasis GO:0043029 28 12 0,000 0,06389291 0,10155522 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06389291 0,10148919 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06389291 0,10142324 ! oocyte differentiation GO:0009994 21 12 0,000 0,06389291 0,10135738 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06389291 0,10129161 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06389291 0,10122592 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06389291 0,10116032 ! defense response to fungus GO:0050832 15 12 0,000 0,06389291 0,1010948 ! developmental induction GO:0031128 22 12 0,000 0,06389291 0,10102937 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,06389291 0,10096402 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06389291 0,10089875 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06389291 0,10083357 ! localization within membrane GO:0051668 26 12 0,000 0,06389291 0,10076848 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,0655375 0,10329556 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,0655375 0,10322896 ! neurotransmitter transport GO:0006836 142 77 1,000 0,06704964 0,10554269 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,06704964 0,10547473 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,06704964 0,10540686 ! lipoprotein metabolic process GO:0042157 147 78 1,000 0,06857333 0,10773289 ! fertilization GO:0009566 99 78 1,000 0,06857333 0,10766365 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,06857333 0,1075945 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,06903027 0,10824195 ! cGMP metabolic process GO:0046068 18 13 0,000 0,06903027 0,10817252 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,06903027 0,10810318 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,06903027 0,10803392 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,06903027 0,10796476 ! peroxisomal transport GO:0043574 28 13 0,000 0,06903027 0,10789568 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,06903027 0,1078267 ! cartilage condensation GO:0001502 22 13 0,000 0,06903027 0,1077578 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,06903027 0,10768899 ! organelle fusion GO:0048284 36 13 0,000 0,06903027 0,10762026 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,06903027 0,10755163 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,06903027 0,10748308 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,06903027 0,10741462 ! endocrine pancreas development GO:0031018 25 13 0,000 0,06903027 0,10734625 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,06903027 0,10727796 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,06903027 0,10720976 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,06903027 0,10714165 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,06903027 0,10707362 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,06903027 0,10700568 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,06903027 0,10693783 ! methionine metabolic process GO:0006555 31 13 0,000 0,06903027 0,10687006 ! plasma membrane organization GO:0007009 27 13 0,000 0,06903027 0,10680238 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,06903027 0,10673478 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,06903027 0,10666727 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,06903027 0,10659984 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,06903027 0,1065325 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,06903027 0,10646525 ! cytokine metabolic process GO:0042107 24 13 0,000 0,06903027 0,10639808 ! exocrine system development GO:0035272 34 13 0,000 0,06903027 0,10633099 ! asymmetric protein localization GO:0008105 24 13 0,000 0,06903027 0,10626399 ! monoamine transport GO:0015844 21 13 0,000 0,06903027 0,10619707 ! L-glutamate transport GO:0015813 30 13 0,000 0,06903027 0,10613024 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,06903027 0,10606349 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,06903027 0,10599683 ! protein homotetramerization GO:0051289 24 13 0,000 0,06903027 0,10593025 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,06903027 0,10586375 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,06903027 0,10579734 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,06903027 0,10573101 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,06903027 0,10566476 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,06903027 0,10559859 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,06903027 0,10553251 ! histone methylation GO:0016571 29 13 0,000 0,06903027 0,10546651 ! chromatin silencing GO:0006342 29 13 0,000 0,06903027 0,1054006 ! gland morphogenesis GO:0022612 31 13 0,000 0,06903027 0,10533476 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,06903027 0,10526901 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,06903027 0,10520334 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,06903027 0,10513775 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,06903027 0,10507225 ! spleen development GO:0048536 24 13 0,000 0,06903027 0,10500682 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,06903027 0,10494148 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,06903027 0,10487622 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,06903027 0,10481103 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,06903027 0,10474593 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,06903027 0,10468091 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,06903027 0,10461598 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,06903027 0,10455112 ! insulin secretion GO:0030073 24 13 0,000 0,06903027 0,10448634 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,06903027 0,10442164 ! acrosome reaction GO:0007340 19 13 0,000 0,06903027 0,10435703 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,06903027 0,10429249 ! blood coagulation GO:0007596 151 79 1,000 0,07010841 0,10585589 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,07010841 0,10579051 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,07010841 0,10572521 ! protein oligomerization GO:0051259 149 79 1,000 0,07010841 0,10565998 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,0716547 0,10792382 ! muscle cell differentiation GO:0042692 178 81 1,000 0,07321206 0,11020151 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,07321206 0,11013365 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07413959 0,11146032 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,07413959 0,11139177 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07413959 0,1113233 ! non-recombinational repair GO:0000726 29 14 0,000 0,07413959 0,11125492 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07413959 0,11118662 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07413959 0,11111841 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,07413959 0,11105028 ! RNA polyadenylation GO:0043631 32 14 0,000 0,07413959 0,11098224 ! lipid localization GO:0010876 32 14 0,000 0,07413959 0,11091428 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,07413959 0,1108464 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,07413959 0,1107786 ! regulated secretory pathway GO:0045055 24 14 0,000 0,07413959 0,11071089 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07413959 0,11064326 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07413959 0,11057571 ! arginine metabolic process GO:0006525 21 14 0,000 0,07413959 0,11050824 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07413959 0,11044086 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,07413959 0,11037356 ! regulation of heart rate GO:0002027 25 14 0,000 0,07413959 0,11030634 ! fear response GO:0042596 34 14 0,000 0,07413959 0,1102392 ! organic alcohol transport GO:0015850 29 14 0,000 0,07413959 0,11017215 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07413959 0,11010517 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,07413959 0,11003828 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,07413959 0,10997147 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07413959 0,10990474 ! bone mineralization GO:0030282 18 14 0,000 0,07413959 0,10983809 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07413959 0,10977152 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,07413959 0,10970503 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07413959 0,10963863 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,07413959 0,1095723 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07413959 0,10950605 ! regulation of cellular pH GO:0030641 27 14 0,000 0,07413959 0,10943989 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07413959 0,1093738 ! ribosome assembly GO:0042255 18 14 0,000 0,07413959 0,10930779 ! cerebellum development GO:0021549 23 14 0,000 0,07413959 0,10924186 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07413959 0,10917602 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07413959 0,10911025 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07413959 0,10904456 ! response to gamma radiation GO:0010332 30 14 0,000 0,07413959 0,10897895 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07413959 0,10891342 ! NADP metabolic process GO:0006739 24 14 0,000 0,07413959 0,10884796 ! oxygen transport GO:0015671 22 14 0,000 0,07413959 0,10878259 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07413959 0,10871729 ! male genitalia development GO:0030539 26 14 0,000 0,07413959 0,10865208 ! regulation of axon extension GO:0030516 43 14 0,000 0,07413959 0,10858694 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,07413959 0,10852188 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07413959 0,10845689 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,07413959 0,10839199 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,07478029 0,10926331 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,07635925 0,11150367 ! exocytosis GO:0006887 153 83 1,000 0,07635925 0,11143706 ! response to drug GO:0042493 149 83 1,000 0,07635925 0,11137053 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,07635925 0,11130408 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,07635925 0,11123771 ! T cell activation GO:0042110 189 84 1,000 0,07794876 0,11348559 ! response to nutrient GO:0007584 135 84 1,000 0,07794876 0,113418 ! digestion GO:0007586 130 84 1,000 0,07794876 0,11335049 ! regulation of ligase activity GO:0051340 147 84 1,000 0,07794876 0,11328306 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,07922101 0,11506356 ! lactation GO:0007595 30 15 0,000 0,07922101 0,1149952 ! reproductive cellular process GO:0048610 22 15 0,000 0,07922101 0,11492691 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,07922101 0,1148587 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! superoxide anion generation GO:0042554 22 15 0,000 0,07922101 0,11479058 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,07922101 0,11472253 ! copper ion transport GO:0006825 22 15 0,000 0,07922101 0,11465457 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,07922101 0,11458669 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,07922101 0,11451889 ! sulfate transport GO:0008272 27 15 0,000 0,07922101 0,11445116 ! response to cAMP GO:0051591 25 15 0,000 0,07922101 0,11438352 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,07922101 0,11431596 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,07922101 0,11424847 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,07922101 0,11418107 ! response to hexose stimulus GO:0009746 25 15 0,000 0,07922101 0,11411375 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! vesicle coating GO:0006901 38 15 0,000 0,07922101 0,1140465 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,07922101 0,11397934 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,07922101 0,11391225 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,07922101 0,11384524 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,07922101 0,11377832 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,07922101 0,11371147 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,07922101 0,1136447 ! regulation of vasodilation GO:0042312 27 15 0,000 0,07922101 0,113578 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,07922101 0,11351139 ! histone deacetylation GO:0016575 24 15 0,000 0,07922101 0,11344485 ! water homeostasis GO:0030104 28 15 0,000 0,07922101 0,11337839 ! cofactor transport GO:0051181 30 15 0,000 0,07922101 0,11331201 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,07922101 0,11324571 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,07922101 0,11317948 ! dopamine metabolic process GO:0042417 35 15 0,000 0,07922101 0,11311333 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,07922101 0,11304726 ! heme biosynthetic process GO:0006783 33 15 0,000 0,07922101 0,11298127 ! cell killing GO:0001906 32 15 0,000 0,07922101 0,11291535 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,07922101 0,11284951 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,07922101 0,11278375 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,07922101 0,11271806 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,07922101 0,11265245 ! actin filament polymerization GO:0030041 27 15 0,000 0,07922101 0,11258692 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,07922101 0,11252146 ! hemostasis GO:0007599 165 85 1,000 0,07954867 0,11292121 ! negative regulation of transport GO:0051051 164 85 1,000 0,07954867 0,11285563 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,07954867 0,11279014 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,07954867 0,11272471 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,08115881 0,1149397 ! regulation of lyase activity GO:0051339 169 86 1,000 0,08115881 0,11487311 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,08115881 0,11480659 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 1,000 0,08277903 0,11703078 ! regulation of protein transport GO:0051223 165 87 1,000 0,08277903 0,11696309 GO:0070201|regulation of establishment of protein localization, ! positive regulation of cell size GO:0045793 29 16 0,000 0,08427468 0,11900754 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,08427468 0,11893878 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,08427468 0,11887011 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,08427468 0,11880152 ! bone remodeling GO:0046849 28 16 0,000 0,08427468 0,11873301 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,08427468 0,11866457 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,08427468 0,11859622 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08427468 0,11852794 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,08427468 0,11845974 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,08427468 0,11839163 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,08427468 0,11832358 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,08427468 0,11825562 ! startle response GO:0001964 28 16 0,000 0,08427468 0,11818774 ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,08427468 0,11811993 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,08427468 0,1180522 ! protein polyubiquitination GO:0000209 41 16 0,000 0,08427468 0,11798455 ! glutamate metabolic process GO:0006536 25 16 0,000 0,08427468 0,11791697 ! response to osmotic stress GO:0006970 27 16 0,000 0,08427468 0,11784948 ! lysosomal transport GO:0007041 31 16 0,000 0,08427468 0,11778206 ! fructose metabolic process GO:0006000 25 16 0,000 0,08427468 0,11771471 ! L-amino acid transport GO:0015807 33 16 0,000 0,08427468 0,11764745 ! stem cell development GO:0048864 46 16 0,000 0,08427468 0,11758026 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08427468 0,11751315 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08427468 0,11744611 ! intermediate filament-based process GO:0045103 36 16 0,000 0,08427468 0,11737915 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,08427468 0,11731227 ! negative regulation of immune response GO:0050777 38 16 0,000 0,08427468 0,11724546 ! axon cargo transport GO:0008088 46 16 0,000 0,08427468 0,11717873 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,08427468 0,11711208 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,08427468 0,1170455 ! DNA replication initiation GO:0006270 28 16 0,000 0,08427468 0,116979 ! neuron recognition GO:0008038 40 16 0,000 0,08427468 0,11691257 ! mRNA splice site selection GO:0006376 44 16 0,000 0,08427468 0,11684622 ! tissue regeneration GO:0042246 27 16 0,000 0,08427468 0,11677994 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,08427468 0,11671374 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,08427468 0,11664761 ! biomineral formation GO:0031214 22 16 0,000 0,08427468 0,11658156 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,08427468 0,11651558 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,08427468 0,11644968 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08427468 0,11638385 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,08427468 0,1163181 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,08427468 0,11625242 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,08427468 0,11618682 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,08427468 0,11612128 ! peptide hormone processing GO:0016486 27 16 0,000 0,08427468 0,11605583 ! cellular respiration GO:0045333 143 88 1,000 0,08440917 0,11617555 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,08440917 0,11611014 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,08604907 0,11829931 ! oxidative phosphorylation GO:0006119 152 90 1,000 0,08769858 0,12049922 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,08769858 0,12043149 ! response to unfolded protein GO:0006986 139 90 1,000 0,08769858 0,12036383 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,08930075 0,12249396 ! metencephalon development GO:0022037 32 17 0,000 0,08930075 0,12242522 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,08930075 0,12235656 ! endothelial cell migration GO:0043542 31 17 0,000 0,08930075 0,12228797 ! gene silencing by RNA GO:0031047 38 17 0,000 0,08930075 0,12221946 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,08930075 0,12215103 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,08930075 0,12208268 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,08930075 0,1220144 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,08930075 0,12194619 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,08930075 0,12187807 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,08930075 0,12181002 ! myoblast differentiation GO:0045445 50 17 0,000 0,08930075 0,12174204 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,08930075 0,12167414 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,08930075 0,12160632 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,08930075 0,12153857 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,08930075 0,1214709 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,08930075 0,12140331 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,08930075 0,12133578 ! NAD metabolic process GO:0019674 33 17 0,000 0,08930075 0,12126834 ! membrane budding GO:0006900 42 17 0,000 0,08930075 0,12120097 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,08930075 0,12113367 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,08930075 0,12106645 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,08930075 0,1209993 ! genitalia development GO:0048806 32 17 0,000 0,08930075 0,12093223 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,08930075 0,12086523 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,08930075 0,12079831 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,08930075 0,12073146 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,08930075 0,12066468 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,08930075 0,12059798 ! steroid catabolic process GO:0006706 34 17 0,000 0,08930075 0,12053135 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,08930075 0,12046479 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,08930075 0,12039831 ! gas transport GO:0015669 26 17 0,000 0,08930075 0,1203319 ! organic cation transport GO:0015695 32 17 0,000 0,08930075 0,12026557 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,08930075 0,12019931 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,08935754 0,1202095 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! positive regulation of MAP kinase activity GO:0043406 174 93 1,000 0,09270321 0,12464168 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,09429938 0,12671804 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,09429938 0,12664838 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,09429938 0,12657879 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,09429938 0,12650928 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,09429938 0,12643984 ! adult walking behavior GO:0007628 36 18 0,000 0,09429938 0,12637049 ! patterning of blood vessels GO:0001569 43 18 0,000 0,09429938 0,1263012 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,09429938 0,126232 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,09429938 0,12616287 ! centrosome cycle GO:0007098 26 18 0,000 0,09429938 0,12609381 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,09429938 0,12602483 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,09429938 0,12595593 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,09429938 0,1258871 ! glycine metabolic process GO:0006544 30 18 0,000 0,09429938 0,12581835 ! glutamine metabolic process GO:0006541 29 18 0,000 0,09429938 0,12574967 ! response to retinoic acid GO:0032526 31 18 0,000 0,09429938 0,12568107 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,09429938 0,12561254 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 0,000 0,09429938 0,12554408 ! DNA integration GO:0015074 32 18 0,000 0,09429938 0,12547571 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,09429938 0,1254074 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,09429938 0,12533917 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,09429938 0,12527101 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,09429938 0,12520293 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,09429938 0,12513492 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,09429938 0,12506699 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,09429938 0,12499913 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,09429938 0,12493134 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,09429938 0,12486363 ! detection of bacterium GO:0016045 22 18 0,000 0,09429938 0,12479599 ! nerve development GO:0021675 34 18 0,000 0,09429938 0,12472842 ! defense response to virus GO:0051607 43 18 0,000 0,09429938 0,12466093 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,09429938 0,12459351 ! regulation of membrane potential GO:0042391 179 94 1,000 0,09438962 0,12464532 ! regulation of defense response GO:0031347 171 95 1,000 0,09608489 0,12681544 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,09608489 0,12674697 ! cofactor biosynthetic process GO:0051188 161 95 1,000 0,09608489 0,12667857 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,09608489 0,12661024 ! response to protein stimulus GO:0051789 158 96 1,000 0,09778886 0,12878609 ! regulation of T cell activation GO:0050863 175 96 1,000 0,09778886 0,1287167 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,09927072 0,13059686 ! positive regulation of translation GO:0045727 31 19 0,000 0,09927072 0,13052657 ! negative regulation of defense response GO:0031348 27 19 0,000 0,09927072 0,13045636 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,09927072 0,13038622 ! neuron maturation GO:0042551 46 19 0,000 0,09927072 0,13031616 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,09927072 0,13024617 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,09927072 0,13017626 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,09927072 0,13010642 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,09927072 0,13003666 ! inositol metabolic process GO:0006020 33 19 0,000 0,09927072 0,12996697 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,09927072 0,12989736 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,09927072 0,12982782 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,09927072 0,12975835 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,09927072 0,12968897 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,09927072 0,12961965 ! response to vitamin A GO:0033189 32 19 0,000 0,09927072 0,12955041 ! heme metabolic process GO:0042168 40 19 0,000 0,09927072 0,12948124 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,09927072 0,12941215 ! response to fungus GO:0009620 26 19 0,000 0,09927072 0,12934313 ! protein export from nucleus GO:0006611 40 19 0,000 0,09927072 0,12927418 ! heart process GO:0003015 32 19 0,000 0,09927072 0,12920531 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,09927072 0,12913651 ! visual learning GO:0008542 38 19 0,000 0,09927072 0,12906778 ! cellular pigmentation GO:0033059 37 19 0,000 0,09927072 0,12899913 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,09927072 0,12893055 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,09927072 0,12886204 ! vitamin transport GO:0051180 31 19 0,000 0,09927072 0,12879361 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,09927072 0,12872525 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,09927072 0,12865696 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,09927072 0,12858874 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,09927072 0,1285206 ! cilium assembly GO:0042384 38 19 0,000 0,09927072 0,12845252 ! peptide hormone secretion GO:0030072 32 19 0,000 0,09927072 0,12838452 ! regulation of protein localization GO:0032880 188 97 1,000 0,0995014 0,12861477 ! forebrain development GO:0030900 210 98 1,000 0,10122235 0,13077007 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,10122235 0,13070095 ! protein secretion GO:0009306 45 20 0,000 0,1042149 0,13449393 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,1042149 0,13442292 ! positive regulation of ossification GO:0045778 50 20 0,000 0,1042149 0,13435198 ! skin development GO:0043588 42 20 0,000 0,1042149 0,13428112 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,1042149 0,13421034 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,1042149 0,13413963 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,1042149 0,13406899 ! response to vitamin GO:0033273 36 20 0,000 0,1042149 0,13399843 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,1042149 0,13392794 ! bile acid metabolic process GO:0008206 34 20 0,000 0,1042149 0,13385752 ! response to alkaloid GO:0043279 38 20 0,000 0,1042149 0,13378718 ! retinoid metabolic process GO:0001523 34 20 0,000 0,1042149 0,13371692 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,1042149 0,13364673 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,1042149 0,13357661 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,1042149 0,13350656 GO:0032392|DNA geometric change, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,1042149 0,13343659 ! body fluid secretion GO:0007589 33 20 0,000 0,1042149 0,13336669 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,1042149 0,13329686 ! peptide secretion GO:0002790 38 20 0,000 0,1042149 0,13322711 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,1042149 0,13315743 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,1042149 0,13308783 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,1042149 0,13301829 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,1042149 0,13294883 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,1042149 0,13287944 ! cell-cell junction organization GO:0045216 43 20 0,000 0,1042149 0,13281013 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,1042149 0,13274088 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,1042149 0,13267171 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,1042149 0,13260261 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,1042149 0,13253358 ! regulation of glucose import GO:0046324 30 20 0,000 0,1042149 0,13246463 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,1042149 0,13239574 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,1042149 0,13232693 ! negative regulation of translation GO:0017148 32 20 0,000 0,1042149 0,13225819 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,1042149 0,13218952 ! positive regulation of immune response GO:0050778 175 100 1,000 0,10468894 0,13272188 ! regulation of cell killing GO:0031341 46 21 0,000 0,10913209 0,13828304 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,10913209 0,13821135 ! hormone secretion GO:0046879 39 21 0,000 0,10913209 0,13813974 ! cAMP metabolic process GO:0046058 41 21 0,000 0,10913209 0,1380682 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,10913209 0,13799674 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,10913209 0,13792535 ! ovarian follicle development GO:0001541 39 21 0,000 0,10913209 0,13785403 ! smooth muscle contraction GO:0006939 48 21 0,000 0,10913209 0,13778279 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 0,000 0,10913209 0,13771162 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,10913209 0,13764052 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,10913209 0,1375695 ! plasma membrane fusion GO:0045026 33 21 0,000 0,10913209 0,13749855 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,10913209 0,13742768 ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,10913209 0,13735688 ! sensory perception of pain GO:0019233 33 21 0,000 0,10913209 0,13728615 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,10913209 0,13721549 ! collagen fibril organization GO:0030199 62 21 0,000 0,10913209 0,13714491 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,10913209 0,13707439 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,10913209 0,13700395 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,10913209 0,13693359 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,10913209 0,13686329 ! collagen catabolic process GO:0030574 29 21 0,000 0,10913209 0,13679307 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,10913209 0,13672292 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,10913209 0,13665284 ! sperm-egg recognition GO:0035036 23 21 0,000 0,10913209 0,13658284 ! actin filament-based movement GO:0030048 47 21 0,000 0,10913209 0,1365129 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,10913209 0,13644304 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,11402242 0,14248428 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,11402242 0,14241144 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,11402242 0,14233867 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,11402242 0,14226597 ! microtubule-based transport GO:0010970 59 22 0,000 0,11402242 0,14219335 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,11402242 0,1421208 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,11402242 0,14204833 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,11402242 0,14197593 ! vacuolar transport GO:0007034 41 22 0,000 0,11402242 0,1419036 ! central nervous system neuron development GO:0021954 47 22 0,000 0,11402242 0,14183135 ! fucose metabolic process GO:0006004 44 22 0,000 0,11402242 0,14175917 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,11402242 0,14168707 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,11402242 0,14161504 ! ureteric bud development GO:0001657 50 22 0,000 0,11402242 0,14154308 ! cell aging GO:0007569 48 22 0,000 0,11402242 0,14147119 ! stem cell differentiation GO:0048863 57 22 0,000 0,11402242 0,14139938 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,11402242 0,14132764 ! cytolysis GO:0019835 27 22 0,000 0,11402242 0,14125597 ! renal system process GO:0003014 42 22 0,000 0,11402242 0,14118438 ! vasodilation GO:0042311 40 22 0,000 0,11402242 0,14111285 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,11402242 0,14104141 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,11402242 0,14097003 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,11402242 0,14089872 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,11402242 0,14082749 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,11402242 0,14075633 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,11402242 0,14068524 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,11402242 0,14061422 ! sarcomere organization GO:0045214 32 22 0,000 0,11402242 0,14054328 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,11402242 0,1404724 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,11402242 0,1404016 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,11402242 0,14033087 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,11402242 0,14026021 ! gut development GO:0048565 44 22 0,000 0,11402242 0,14018962 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,11402242 0,1401191 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,11888604 0,14602243 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,11888604 0,14594905 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,11888604 0,14587574 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,11888604 0,14580251 ! gluconeogenesis GO:0006094 38 23 0,000 0,11888604 0,14572936 ! glycerol metabolic process GO:0006071 40 23 0,000 0,11888604 0,14565627 ! viral genome replication GO:0019079 44 23 0,000 0,11888604 0,14558326 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,11888604 0,14551032 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,11888604 0,14543746 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,11888604 0,14536467 ! regeneration GO:0031099 42 23 0,000 0,11888604 0,14529195 ! axis specification GO:0009798 43 23 0,000 0,11888604 0,1452193 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,11888604 0,14514673 ! response to ethanol GO:0045471 47 23 0,000 0,11888604 0,14507423 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,11888604 0,1450018 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,11888604 0,14492944 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,11888604 0,14485716 ! peroxisome organization GO:0007031 43 23 0,000 0,11888604 0,14478495 ! lysosome organization GO:0007040 47 23 0,000 0,11888604 0,14471281 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,11888604 0,14464074 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,11888604 0,14456874 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,11888604 0,14449682 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,11888604 0,14442497 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,11888604 0,14435318 ! fatty acid transport GO:0015908 47 23 0,000 0,11888604 0,14428147 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,11888604 0,14420983 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,11888604 0,14413827 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,11888604 0,14406677 ! hormone transport GO:0009914 41 23 0,000 0,11888604 0,14399534 ! cell-cell recognition GO:0009988 28 23 0,000 0,11888604 0,14392399 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,11888604 0,1438527 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,11888604 0,14378149 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,11888604 0,14371034 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,1237231 0,14948345 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,1237231 0,14940956 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,1237231 0,14933574 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,1237231 0,149262 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,1237231 0,14918832 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,1237231 0,14911472 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,1237231 0,1490412 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,1237231 0,14896774 ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,1237231 0,14889436 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,1237231 0,14882105 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,1237231 0,14874781 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,1237231 0,14867464 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,1237231 0,14860155 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,1237231 0,14852852 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,1237231 0,14845557 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,1237231 0,14838269 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,1237231 0,14830988 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,1237231 0,14823715 ! membrane depolarization GO:0051899 45 24 0,000 0,1237231 0,14816448 ! oogenesis GO:0048477 44 24 0,000 0,1237231 0,14809189 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,1237231 0,14801937 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,1237231 0,14794691 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,1237231 0,14787453 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,1237231 0,14780222 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,1237231 0,14772998 GO:0033013|tetrapyrrole metabolic process, ! regulation of amine transport GO:0051952 41 24 0,000 0,1237231 0,14765781 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,12853375 0,15332419 ! leukocyte adhesion GO:0007159 55 25 0,000 0,12853375 0,15324936 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,12853375 0,15317461 ! phototransduction GO:0007602 37 25 0,000 0,12853375 0,15309992 ! keratinization GO:0031424 37 25 0,000 0,12853375 0,15302531 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,12853375 0,15295078 ! vacuole organization GO:0007033 49 25 0,000 0,12853375 0,15287631 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,12853375 0,15280192 ! chromosome condensation GO:0030261 48 25 0,000 0,12853375 0,1527276 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,12853375 0,15265335 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,12853375 0,15257918 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,12853375 0,15250507 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,12853375 0,15243104 ! immunoglobulin production GO:0002377 62 25 0,000 0,12853375 0,15235708 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,12853375 0,15228319 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,12853375 0,15220938 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,12853375 0,15213563 ! liver development GO:0001889 55 25 0,000 0,12853375 0,15206196 ! protein tetramerization GO:0051262 57 25 0,000 0,12853375 0,15198836 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,13331811 0,1575695 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,13331811 0,1574933 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,13331811 0,15741718 ! molting cycle process GO:0022404 52 26 0,000 0,13331811 0,15734114 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! protein amino acid alkylation GO:0008213 59 26 0,000 0,13331811 0,15726516 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,13331811 0,15718926 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,13331811 0,15711344 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,13331811 0,15703768 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,13331811 0,156962 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,13331811 0,15688639 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,13331811 0,15681086 ! osteoblast differentiation GO:0001649 63 26 0,000 0,13331811 0,1567354 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,13331811 0,15666001 ! negative regulation of cell development GO:0010721 83 26 0,000 0,13331811 0,15658469 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,13331811 0,15650944 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,13331811 0,15643427 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,13331811 0,15635917 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,13331811 0,15628414 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,13331811 0,15620919 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,13331811 0,1561343 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,13331811 0,15605949 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,13331811 0,15598475 ! blastocyst development GO:0001824 50 26 0,000 0,13331811 0,15591008 ! telomere organization GO:0032200 46 26 0,000 0,13331811 0,15583548 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,13331811 0,15576095 ! alditol metabolic process GO:0019400 44 26 0,000 0,13331811 0,1556865 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,13331811 0,15561211 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,13331811 0,1555378 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,13807635 0,16101218 ! embryonic pattern specification GO:0009880 49 27 0,000 0,13807635 0,16093536 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,13807635 0,16085862 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,13807635 0,16078194 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,13807635 0,16070534 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,13807635 0,16062882 ! iron ion transport GO:0006826 65 27 0,000 0,13807635 0,16055236 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,13807635 0,16047598 ! superoxide metabolic process GO:0006801 41 27 0,000 0,13807635 0,16039968 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,13807635 0,16032344 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,13807635 0,16024728 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,13807635 0,16017119 ! response to toxin GO:0009636 49 27 0,000 0,13807635 0,16009517 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,13807635 0,16001922 ! leukocyte proliferation GO:0070661 59 27 0,000 0,13807635 0,15994335 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,14280859 0,16534663 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,14280859 0,1652683 ! vesicle docking GO:0048278 55 28 0,000 0,14280859 0,16519005 ! circadian rhythm GO:0007623 56 28 0,000 0,14280859 0,16511187 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,14280859 0,16503377 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,14280859 0,16495574 ! base-excision repair GO:0006284 41 28 0,000 0,14280859 0,16487778 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,14280859 0,1647999 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,14280859 0,16472209 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,14280859 0,16464436 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,14280859 0,16456669 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,14280859 0,1644891 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,14280859 0,16441159 ! glutathione metabolic process GO:0006749 42 28 0,000 0,14280859 0,16433414 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,14280859 0,16425677 ! lipid oxidation GO:0034440 48 28 0,000 0,14280859 0,16417948 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,14280859 0,16410225 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,14280859 0,1640251 ! translational initiation GO:0006413 66 29 0,000 0,14751499 0,16935109 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,14751499 0,16927154 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,14751499 0,16919207 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,14751499 0,16911268 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,14751499 0,16903335 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,14751499 0,16895411 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,14751499 0,16887494 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,14751499 0,16879584 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,14751499 0,16871681 ! synaptogenesis GO:0007416 46 29 0,000 0,14751499 0,16863786 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,14751499 0,16855899 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,14751499 0,16848018 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,14751499 0,16840145 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,14751499 0,1683228 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,15219567 0,17358265 ! phenol metabolic process GO:0018958 56 30 0,000 0,15219567 0,17350165 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,15219567 0,17342072 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,15219567 0,17333987 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,15219567 0,1732591 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,15219567 0,1731784 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,15219567 0,17309778 ! acute-phase response GO:0006953 50 30 0,000 0,15219567 0,17301723 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,15219567 0,17293676 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,15219567 0,17285636 ! myofibril assembly GO:0030239 50 30 0,000 0,15219567 0,17277604 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,15219567 0,17269579 ! determination of left/right symmetry GO:0007368 53 30 0,000 0,15219567 0,17261561 ! cell fate determination GO:0001709 64 30 0,000 0,15219567 0,17253551 ! phospholipid transport GO:0015914 65 30 0,000 0,15219567 0,17245549 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,15219567 0,17237554 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,15219567 0,17229566 GO:0046496|nicotinamide nucleotide metabolic process, ! tissue homeostasis GO:0001894 50 30 0,000 0,15219567 0,17221585 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,15219567 0,17213612 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,15685079 0,17731906 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,15685079 0,17723704 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,15685079 0,1771551 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,15685079 0,17707324 ! cell junction assembly GO:0034329 85 31 0,000 0,15685079 0,17699145 ! regulation of innate immune response GO:0045088 57 31 0,000 0,15685079 0,17690973 ! ovulation cycle process GO:0022602 55 31 0,000 0,15685079 0,17682809 ! peptide transport GO:0015833 60 31 0,000 0,15685079 0,17674653 ! detection of light stimulus GO:0009583 44 31 0,000 0,15685079 0,17666504 ! natural killer cell activation GO:0030101 50 31 0,000 0,15685079 0,17658363 ! cofactor catabolic process GO:0051187 54 31 0,000 0,15685079 0,17650229 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,15685079 0,17642103 ! eye morphogenesis GO:0048592 65 31 0,000 0,15685079 0,17633984 ! response to heat GO:0009408 54 31 0,000 0,15685079 0,17625873 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,15685079 0,17617769 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,16148048 0,18129449 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,16148048 0,18121121 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,16148048 0,18112801 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,16148048 0,18104489 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,16148048 0,18096184 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,16148048 0,18087887 ! muscle cell development GO:0055001 52 32 0,000 0,16148048 0,18079597 ! mesoderm formation GO:0001707 73 32 0,000 0,16148048 0,18071315 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,16148048 0,18063041 ! ovulation cycle GO:0042698 57 32 0,000 0,16148048 0,18054774 ! BMP signaling pathway GO:0030509 71 32 0,000 0,16148048 0,18046515 ! hindbrain development GO:0030902 65 32 0,000 0,16148048 0,18038263 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,16148048 0,18030019 ! gene silencing GO:0016458 71 32 0,000 0,16148048 0,18021782 ! regulation of pH GO:0006885 56 33 0,000 0,16608487 0,18527185 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,16608487 0,18518729 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,16608487 0,1851028 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,16608487 0,1850184 ! response to ionizing radiation GO:0010212 74 33 0,000 0,16608487 0,18493407 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,16608487 0,18484982 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,16608487 0,18476564 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,16608487 0,18468154 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,16608487 0,18459752 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,17066412 0,18960093 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,17066412 0,18951474 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,17066412 0,18942864 ! spliceosome assembly GO:0000245 75 34 0,000 0,17066412 0,18934261 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,17066412 0,18925667 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,17066412 0,1891708 ! formation of primary germ layer GO:0001704 76 34 0,000 0,17066412 0,189085 ! cell fate specification GO:0001708 56 34 0,000 0,17066412 0,18899929 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,17066412 0,18891365 ! adult locomotory behavior GO:0008344 62 34 0,000 0,17066412 0,1888281 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,17521834 0,19377927 ! negative regulation of secretion GO:0051048 68 35 0,000 0,17521834 0,19369159 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,17521834 0,19360398 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,17521834 0,19351646 ! membrane docking GO:0022406 69 35 0,000 0,17521834 0,19342901 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,17521834 0,19334165 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,17521834 0,19325436 ! ceramide metabolic process GO:0006672 72 35 0,000 0,17521834 0,19316715 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,17521834 0,19308002 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,17521834 0,19299297 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,17974768 0,19789256 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,17974768 0,19780342 ! positive regulation of cell development GO:0010720 85 36 0,000 0,17974768 0,19771436 ! protein targeting to membrane GO:0006612 75 36 0,000 0,17974768 0,19762538 ! regulation of proteolysis GO:0030162 77 36 0,000 0,17974768 0,19753648 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,17974768 0,19744766 ! aerobic respiration GO:0009060 56 36 0,000 0,17974768 0,19735892 ! cytokine production GO:0001816 68 36 0,000 0,17974768 0,19727026 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,17974768 0,19718167 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,18425228 0,20203246 ! odontogenesis GO:0042476 74 37 0,000 0,18425228 0,20194182 ! actomyosin structure organization GO:0031032 68 37 0,000 0,18425228 0,20185126 ! cell junction organization GO:0034330 96 37 0,000 0,18425228 0,20176079 ! female gonad development GO:0008585 71 37 0,000 0,18425228 0,20167039 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,18873226 0,20648138 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,18873226 0,20638895 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,18873226 0,20629661 ! organic anion transport GO:0015711 82 38 0,000 0,18873226 0,20620435 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,18873226 0,20611217 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,18873226 0,20602007 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,18873226 0,20592806 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,18873226 0,20583612 ! glycogen metabolic process GO:0005977 63 38 0,000 0,18873226 0,20574427 ! pigment metabolic process GO:0042440 87 38 0,000 0,18873226 0,20565251 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,19318777 0,21041361 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,19318777 0,21031984 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,19318777 0,21022616 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,19318777 0,21013256 ! glucan metabolic process GO:0044042 64 39 0,000 0,19318777 0,21003904 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,19761893 0,21476114 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,19761893 0,21466565 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,19761893 0,21457024 ! learning GO:0007612 82 40 0,000 0,19761893 0,21447492 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,19761893 0,21437968 GO:0046660|female sex differentiation, ! mismatch repair GO:0006298 58 40 0,000 0,19761893 0,21428453 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,19761893 0,21418946 ! RNA export from nucleus GO:0006405 61 41 0,000 0,20202588 0,21886884 ! mRNA catabolic process GO:0006402 79 41 0,000 0,20202588 0,21877182 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,20202588 0,21867489 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,20202588 0,21857804 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,20202588 0,21848129 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,20202588 0,21838461 ! feeding behavior GO:0007631 69 41 0,000 0,20202588 0,21828802 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,20202588 0,21819152 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,20202588 0,21809511 GO:0015986|ATP synthesis coupled proton transport, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,20640875 0,22272817 ! ear morphogenesis GO:0042471 64 42 0,000 0,20640875 0,22262983 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,20640875 0,22253158 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,20640875 0,22243342 ! regulation of protein secretion GO:0050708 77 42 0,000 0,20640875 0,22233535 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,20640875 0,22223736 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,20640875 0,22213946 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,21076766 0,22673069 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,21076766 0,2266309 ! regulation of tube size GO:0035150 76 43 0,000 0,21076766 0,22653119 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,21076766 0,22643158 ! glucose transport GO:0015758 66 43 0,000 0,21076766 0,22633205 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,21076766 0,2262326 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,21076766 0,22613325 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,21076766 0,22603398 ! ion transmembrane transport GO:0034220 79 43 0,000 0,21076766 0,2259348 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,21510276 0,23048072 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,21510276 0,23037968 ! hexose transport GO:0008645 68 44 0,000 0,21510276 0,23027872 GO:0015749|monosaccharide transport, ! striated muscle contraction GO:0006941 85 44 0,000 0,21510276 0,23017786 ! phagocytosis GO:0006909 105 44 0,000 0,21510276 0,23007708 ! double-strand break repair GO:0006302 85 44 0,000 0,21510276 0,22997639 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,21941417 0,2344833 ! B cell differentiation GO:0030183 124 45 0,000 0,21941417 0,23438077 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,21941417 0,23427833 ! female gamete generation GO:0007292 71 45 0,000 0,21941417 0,23417598 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,21941417 0,23407372 ! polyol metabolic process GO:0019751 77 45 0,000 0,21941417 0,23397155 ! developmental growth GO:0048589 88 45 0,000 0,21941417 0,23386947 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,22370202 0,23833582 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,22370202 0,23823192 ! glycolysis GO:0006096 71 46 0,000 0,22370202 0,23812812 ! leukocyte migration GO:0050900 75 46 0,000 0,22370202 0,2380244 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,22370202 0,23792078 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,22370202 0,23781724 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,22796643 0,24224532 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,23220753 0,24664479 ! mitochondrial transport GO:0006839 94 48 0,000 0,23220753 0,24653759 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,23220753 0,2464305 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,23220753 0,24632349 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,23220753 0,24621658 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,23220753 0,24610976 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,23642546 0,25047155 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,23642546 0,25036298 ! JNK cascade GO:0007254 106 49 0,000 0,23642546 0,25025451 ! protein homooligomerization GO:0051260 84 49 0,000 0,23642546 0,25014612 ! regulation of ion transport GO:0043269 86 50 0,000 0,24062033 0,25447423 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,24062033 0,25436412 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,24062033 0,2542541 ! regulation of ossification GO:0030278 123 50 0,000 0,24062033 0,25414418 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,24062033 0,25403435 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,24062033 0,25392461 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,24479228 0,25821569 ! peptide metabolic process GO:0006518 80 51 0,000 0,24479228 0,25810425 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,24479228 0,2579929 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,24894142 0,26225265 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,24894142 0,26213961 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,24894142 0,26202667 ! amino acid activation GO:0043038 98 52 0,000 0,24894142 0,26191382 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! inner ear development GO:0048839 89 53 0,000 0,25306789 0,2661407 ! chromatin remodeling GO:0006338 122 53 0,000 0,25306789 0,26602618 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,25306789 0,26591176 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,25306789 0,26579744 ! vesicle organization GO:0016050 127 53 0,000 0,25306789 0,26568322 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,25306789 0,26556909 ! regulation of translational initiation GO:0006446 87 54 0,000 0,25717179 0,26975985 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,25717179 0,26964407 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,25717179 0,26952839 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,25717179 0,26941282 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,25717179 0,26929734 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,25717179 0,26918196 ! membrane fusion GO:0006944 122 54 0,000 0,25717179 0,26906668 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,25717179 0,26895149 ! RNA catabolic process GO:0006401 103 55 0,000 0,26125327 0,27310301 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,26125327 0,2729862 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,26125327 0,27286949 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,26125327 0,27275288 ! glucose catabolic process GO:0006007 88 56 0,000 0,26531243 0,27687239 ! RNA elongation GO:0006354 90 56 0,000 0,26531243 0,27675417 ! chloride transport GO:0006821 102 57 0,000 0,2693494 0,28084532 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,2693494 0,28072551 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,2693494 0,28060579 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,2733643 0,28466709 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,2733643 0,2845458 ! gastrulation GO:0007369 122 58 0,000 0,2733643 0,28442461 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,2733643 0,28430353 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,2733643 0,28418255 ! nuclear export GO:0051168 110 59 0,000 0,27735726 0,28821088 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,28132838 0,29221311 ! adult behavior GO:0030534 104 60 0,000 0,28132838 0,29208892 ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,28527779 0,29606357 ! regulation of heart contraction GO:0008016 123 61 0,000 0,28527779 0,29593786 ! proton transport GO:0015992 117 61 0,000 0,28527779 0,29581225 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,28527779 0,29568674 ! mesoderm development GO:0007498 128 63 0,000 0,29311196 0,30367791 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,29311196 0,30354918 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,29311196 0,30342056 ! hydrogen transport GO:0006818 121 64 0,000 0,29699694 0,30731196 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,29699694 0,30718185 ! protein amino acid autophosphorylation GO:0046777 157 64 0,000 0,29699694 0,30705186 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,30086069 0,31091483 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,30086069 0,31078336 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,30086069 0,31065201 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,30086069 0,31052077 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,30086069 0,31038964 ! ear development GO:0043583 114 66 0,000 0,3047033 0,31422126 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,3047033 0,31408868 ! activation of MAPK activity GO:0000187 124 67 0,000 0,30852491 0,31789386 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,30852491 0,31775984 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,30852491 0,31762594 ! secondary metabolic process GO:0019748 125 67 0,000 0,30852491 0,31749214 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,31232561 0,32126799 ! hexose catabolic process GO:0019320 113 68 0,000 0,31232561 0,32113277 ! extracellular matrix organization GO:0030198 146 68 0,000 0,31232561 0,32099767 ! detection of external stimulus GO:0009581 102 68 0,000 0,31232561 0,32086269 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,31232561 0,32072781 ! regulation of lipase activity GO:0060191 137 68 0,000 0,31232561 0,32059305 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,31232561 0,32045841 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,31610553 0,3242006 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 0,000 0,31610553 0,32406455 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,31610553 0,32392862 ! single fertilization GO:0007338 83 69 0,000 0,31610553 0,3237928 ! cell redox homeostasis GO:0045454 114 70 0,000 0,31986478 0,32750615 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,32360348 0,33119535 ! carbohydrate transport GO:0008643 114 72 0,000 0,32732172 0,33486054 ! B cell activation GO:0042113 179 72 0,000 0,32732172 0,33472037 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,32732172 0,33458032 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,32732172 0,33444039 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,32732172 0,33430057 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,32732172 0,33416087 ! humoral immune response GO:0006959 115 73 0,000 0,33101963 0,33779489 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,33101963 0,33765385 ! regulation of immune effector process GO:0002697 156 73 0,000 0,33101963 0,33751292 ! acute inflammatory response GO:0002526 118 74 0,000 0,33469732 0,34112038 ! amino acid transport GO:0006865 148 74 0,000 0,33469732 0,34097813 ! transition metal ion transport GO:0000041 143 75 0,000 0,33835489 0,34456065 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,33835489 0,34441708 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,33835489 0,34427363 ! axon guidance GO:0007411 162 75 0,000 0,33835489 0,3441303 ! rhythmic process GO:0048511 142 75 0,000 0,33835489 0,3439871 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,34199245 0,34754058 ! regulation of blood pressure GO:0008217 134 76 0,000 0,34199245 0,34739608 ! amine catabolic process GO:0009310 136 77 0,000 0,34561012 0,35092499 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,34561012 0,3507792 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,34561012 0,35063352 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,34561012 0,35048797 ! antigen processing and presentation GO:0019882 117 78 0,000 0,349208 0,35398969 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,3527862 0,35746856 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,3527862 0,35732035 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,35634483 0,36077514 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,35634483 0,36062569 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,35988399 0,36405656 ! protein import into nucleus GO:0006606 174 82 0,000 0,36340379 0,367465 ! nuclear import GO:0051170 177 83 0,000 0,36690433 0,37085117 ! inorganic anion transport GO:0015698 156 83 0,000 0,36690433 0,3706978 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,37384807 0,37755719 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,38071603 0,38433441 ! alcohol catabolic process GO:0046164 142 87 0,000 0,38071603 0,38417566 ! nucleosome assembly GO:0006334 126 87 0,000 0,38071603 0,38401704 ! sensory perception of smell GO:0007608 117 88 0,000 0,38412186 0,38729249 ! chromatin assembly GO:0031497 128 88 0,000 0,38412186 0,38713272 ! cellular defense response GO:0006968 123 89 0,000 0,38750905 0,39038541 ! protein localization in nucleus GO:0034504 192 89 0,000 0,38750905 0,39022449 ! regulation of neurological system process GO:0031644 175 89 0,000 0,38750905 0,39006371 ! ossification GO:0001503 205 91 0,000 0,39422793 0,39666344 ! defense response to bacterium GO:0042742 112 91 0,000 0,39422793 0,39650014 ! bone development GO:0060348 206 92 0,000 0,39755982 0,39968669 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,39755982 0,39952228 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,40087348 0,40268664 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,40087348 0,40252113 ! vitamin metabolic process GO:0006766 153 93 0,000 0,40087348 0,40235576 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,40416901 0,40549687 ! female pregnancy GO:0007565 166 94 0,000 0,40416901 0,40533041 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,40416901 0,40516409 ! nucleosome organization GO:0034728 143 95 0,000 0,4074465 0,40828212 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,4074465 0,40811472 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,4074465 0,40794746 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,41394777 0,41428693 ! transcription initiation GO:0006352 171 97 0,000 0,41394777 0,41411728 ! mRNA transport GO:0051028 185 100 0,000 0,42356685 0,42356685