pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6515-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! amyloid precursor protein catabolic process GO:0042987 5 5 2,000 2,827E-07 5,21E-04 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 2,000 5,642E-07 5,199E-04 ! amyloid precursor protein metabolic process GO:0042982 7 7 2,000 9,853E-07 6,053E-04 ! membrane protein ectodomain proteolysis GO:0006509 7 7 2,000 9,853E-07 4,54E-04 GO:0033619|membrane protein proteolysis, ! protein amino acid autophosphorylation GO:0046777 28 28 3,000 1,527E-06 5,628E-04 ! regulation of epithelial cell proliferation GO:0050678 29 29 3,000 1,768E-06 5,429E-04 ! positive regulation of protein import into nucleus GO:0042307 9 9 2,000 2,355E-06 6,2E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 2,000 4,607E-06 1,061E-03 GO:0032388|positive regulation of intracellular transport, ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 2,000 4,607E-06 9,433E-04 ! protein oligomerization GO:0051259 39 39 3,000 5,994E-06 1,105E-03 ! positive regulation of protein kinase activity GO:0045860 89 86 4,000 6,047E-06 1,013E-03 ! glycoprotein catabolic process GO:0006516 13 12 2,000 6,129E-06 9,414E-04 ! positive regulation of transferase activity GO:0051347 91 88 4,000 6,774E-06 9,604E-04 GO:0033674|positive regulation of kinase activity, ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 2,000 7,952E-06 1,047E-03 ! protein tetramerization GO:0051262 13 13 2,000 7,952E-06 9,77E-04 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 1,01E-05 1,163E-03 ! regulation of transcription factor import into nucleus GO:0042990 15 15 2,000 1,26E-05 1,366E-03 ! positive regulation of MAP kinase activity GO:0043406 50 49 3,000 1,512E-05 1,548E-03 ! interphase of mitotic cell cycle GO:0051329 52 51 3,000 1,776E-05 1,723E-03 GO:0051325|interphase, ! regulation of fibroblast proliferation GO:0048145 17 17 2,000 1,875E-05 1,728E-03 ! positive regulation of cell adhesion GO:0045785 17 17 2,000 1,875E-05 1,646E-03 ! Notch signaling pathway GO:0007219 22 21 2,000 3,637E-05 3,047E-03 ! regulation of protein import into nucleus GO:0042306 21 21 2,000 3,637E-05 2,914E-03 ! cell projection assembly GO:0030031 25 23 2,000 4,823E-05 3,704E-03 ! regulation of MAP kinase activity GO:0043405 67 66 3,000 4,963E-05 3,658E-03 ! T cell differentiation GO:0030217 24 24 2,000 5,5E-05 3,899E-03 ! regulation of gene-specific transcription GO:0032583 25 25 2,000 6,237E-05 4,258E-03 ! regulation of intracellular protein transport GO:0033157 25 25 2,000 6,237E-05 4,106E-03 ! positive regulation of hydrolase activity GO:0051345 72 72 3,000 6,995E-05 4,446E-03 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 2,000 7,9E-05 4,853E-03 ! cell morphogenesis involved in differentiation GO:0000904 82 77 3,000 9,105E-05 5,413E-03 ! positive regulation of glucose metabolic process GO:0010907 5 5 1,000 9,705E-05 5,59E-03 ! dopamine receptor signaling pathway GO:0007212 5 5 1,000 9,705E-05 5,42E-03 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 9,705E-05 5,261E-03 ! substrate-bound cell migration, cell extension GO:0006930 5 5 1,000 9,705E-05 5,11E-03 ! receptor clustering GO:0043113 5 5 1,000 9,705E-05 4,968E-03 ! actin cytoskeleton reorganization GO:0031532 5 5 1,000 9,705E-05 4,834E-03 ! protein heterooligomerization GO:0051291 5 5 1,000 9,705E-05 4,707E-03 ! T cell lineage commitment GO:0002360 5 5 1,000 9,705E-05 4,586E-03 ! peptidyl-lysine modification GO:0018205 5 5 1,000 9,705E-05 4,472E-03 ! negative regulation of neuroblast proliferation GO:0007406 5 5 1,000 9,705E-05 4,363E-03 ! positive regulation of protein transport GO:0051222 29 29 2,000 9,828E-05 4,312E-03 ! response to UV GO:0009411 29 29 2,000 9,828E-05 4,212E-03 ! regulation of intracellular transport GO:0032386 31 31 2,000 1,204E-04 5,043E-03 ! regulation of DNA replication GO:0006275 32 31 2,000 1,204E-04 4,931E-03 ! protein maturation by peptide bond cleavage GO:0051605 32 32 2,000 1,326E-04 5,312E-03 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 1,453E-04 5,697E-03 GO:0018409|peptide or protein amino-terminal blocking, ! virus-host interaction GO:0019048 6 6 1,000 1,453E-04 5,579E-03 ! ER overload response GO:0006983 6 6 1,000 1,453E-04 5,465E-03 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 1,453E-04 5,356E-03 GO:0070667|negative regulation of mast cell proliferation, ! G1 DNA damage checkpoint GO:0031571 6 6 1,000 1,453E-04 5,251E-03 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 1,453E-04 5,15E-03 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 1,453E-04 5,052E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 1,000 1,453E-04 4,959E-03 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! regulation of embryonic development GO:0045995 6 6 1,000 1,453E-04 4,869E-03 ! localization within membrane GO:0051668 6 6 1,000 1,453E-04 4,782E-03 ! heart development GO:0007507 90 87 3,000 1,467E-04 4,742E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 2,000 1,739E-04 5,524E-03 ! positive regulation of cell migration GO:0030335 36 36 2,000 1,893E-04 5,912E-03 ! positive regulation of cellular catabolic process GO:0031331 7 7 1,000 2,03E-04 6,236E-03 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 2,03E-04 6,134E-03 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! response to X-ray GO:0010165 7 7 1,000 2,03E-04 6,035E-03 ! regulation of intracellular pH GO:0051453 7 7 1,000 2,03E-04 5,939E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 1,000 2,03E-04 5,846E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! cranial nerve development GO:0021545 7 7 1,000 2,03E-04 5,756E-03 ! autonomic nervous system development GO:0048483 7 7 1,000 2,03E-04 5,669E-03 ! response to gamma radiation GO:0010332 8 7 1,000 2,03E-04 5,585E-03 ! regulation of ATPase activity GO:0043462 7 7 1,000 2,03E-04 5,502E-03 ! negative regulation of T cell activation GO:0050868 7 7 1,000 2,03E-04 5,423E-03 ! regulation of transcription factor activity GO:0051090 38 37 2,000 2,055E-04 5,412E-03 GO:0090046|regulation of transcription regulator activity, ! negative regulation of protein kinase activity GO:0006469 37 37 2,000 2,055E-04 5,335E-03 ! negative regulation of kinase activity GO:0033673 38 38 2,000 2,227E-04 5,7E-03 ! axon guidance GO:0007411 39 38 2,000 2,227E-04 5,622E-03 ! lymphocyte differentiation GO:0030098 39 39 2,000 2,408E-04 5,996E-03 ! positive regulation of cell motion GO:0051272 39 39 2,000 2,408E-04 5,916E-03 ! hemopoiesis GO:0030097 104 100 3,000 2,514E-04 6,096E-03 ! negative regulation of transferase activity GO:0051348 40 40 2,000 2,597E-04 6,217E-03 ! sex determination GO:0007530 8 8 1,000 2,702E-04 6,384E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 1,000 2,702E-04 6,303E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 1,000 2,702E-04 6,224E-03 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 2,702E-04 6,147E-03 ! cytoplasmic sequestering of protein GO:0051220 8 8 1,000 2,702E-04 6,072E-03 ! regulation of caspase activity GO:0043281 41 41 2,000 2,797E-04 6,21E-03 ! regulation of endopeptidase activity GO:0052548 42 42 2,000 3,006E-04 6,594E-03 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 3,467E-04 7,517E-03 ! substrate-bound cell migration GO:0006929 9 9 1,000 3,467E-04 7,43E-03 ! regulation of cellular pH GO:0030641 9 9 1,000 3,467E-04 7,344E-03 ! histone acetylation GO:0016573 9 9 1,000 3,467E-04 7,261E-03 ! regulation of calcium-mediated signaling GO:0050848 9 9 1,000 3,467E-04 7,179E-03 ! regulation of DNA binding GO:0051101 47 45 2,000 3,692E-04 7,56E-03 ! protein processing GO:0016485 45 45 2,000 3,692E-04 7,477E-03 ! regulation of peptidase activity GO:0052547 46 46 2,000 3,941E-04 7,896E-03 ! regulation of catabolic process GO:0009894 48 47 2,000 4,201E-04 8,326E-03 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 1,000 4,325E-04 8,48E-03 ! regulation of glucose metabolic process GO:0010906 10 10 1,000 4,325E-04 8,391E-03 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 4,325E-04 8,303E-03 ! centrosome cycle GO:0007098 10 10 1,000 4,325E-04 8,218E-03 ! neuromuscular junction development GO:0007528 10 10 1,000 4,325E-04 8,134E-03 ! regulation of erythrocyte differentiation GO:0045646 10 10 1,000 4,325E-04 8,052E-03 ! nerve development GO:0021675 10 10 1,000 4,325E-04 7,971E-03 ! epithelial to mesenchymal transition GO:0001837 10 10 1,000 4,325E-04 7,892E-03 ! positive regulation of neuron apoptosis GO:0043525 10 10 1,000 4,325E-04 7,815E-03 ! protein stabilization GO:0050821 10 10 1,000 4,325E-04 7,739E-03 ! leukocyte differentiation GO:0002521 50 49 2,000 4,754E-04 8,425E-03 ! cell cycle arrest GO:0007050 49 49 2,000 4,754E-04 8,344E-03 ! skeletal muscle tissue development GO:0007519 50 49 2,000 4,754E-04 8,266E-03 GO:0060538|skeletal muscle organ development, ! regulation of DNA metabolic process GO:0051052 51 50 2,000 5,047E-04 8,693E-03 ! T cell activation GO:0042110 51 50 2,000 5,047E-04 8,613E-03 ! anterior/posterior pattern formation GO:0009952 51 50 2,000 5,047E-04 8,534E-03 ! G1 phase of mitotic cell cycle GO:0000080 12 11 1,000 5,276E-04 8,84E-03 ! signal complex assembly GO:0007172 11 11 1,000 5,276E-04 8,76E-03 ! protein amino acid acetylation GO:0006473 11 11 1,000 5,276E-04 8,682E-03 ! activation of MAPKK activity GO:0000186 12 11 1,000 5,276E-04 8,605E-03 ! cellular response to starvation GO:0009267 11 11 1,000 5,276E-04 8,53E-03 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 1,000 5,276E-04 8,455E-03 ! G1/S transition checkpoint GO:0031575 12 11 1,000 5,276E-04 8,383E-03 ! interaction with host GO:0051701 11 11 1,000 5,276E-04 8,311E-03 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 5,276E-04 8,241E-03 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 1,000 5,276E-04 8,171E-03 GO:0006109|regulation of carbohydrate metabolic process, ! hindbrain development GO:0030902 11 11 1,000 5,276E-04 8,103E-03 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 5,276E-04 8,036E-03 ! protein maturation GO:0051604 51 51 2,000 5,351E-04 8,084E-03 ! response to light stimulus GO:0009416 53 52 2,000 5,667E-04 8,492E-03 ! regulation of protein transport GO:0051223 53 53 2,000 5,995E-04 8,91E-03 GO:0070201|regulation of establishment of protein localization, ! microtubule organizing center organization GO:0031023 12 12 1,000 6,319E-04 9,317E-03 GO:0051297|centrosome organization, ! somitogenesis GO:0001756 13 12 1,000 6,319E-04 9,243E-03 ! G1 phase GO:0051318 13 12 1,000 6,319E-04 9,17E-03 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 1,000 6,319E-04 9,098E-03 ! regulation of cell adhesion GO:0030155 56 55 2,000 6,686E-04 9,552E-03 ! regulation of binding GO:0051098 60 57 2,000 7,426E-04 0,01052781 ! regulation of protein localization GO:0032880 58 57 2,000 7,426E-04 0,01044744 ! positive regulation of DNA replication GO:0045740 14 13 1,000 7,453E-04 0,01040664 ! G2/M transition of mitotic cell cycle GO:0000086 13 13 1,000 7,453E-04 0,0103284 ! mitochondrial membrane organization GO:0007006 13 13 1,000 7,453E-04 0,01025132 ! negative regulation of DNA replication GO:0008156 13 13 1,000 7,453E-04 0,01017538 ! receptor metabolic process GO:0043112 14 13 1,000 7,453E-04 0,01010056 ! negative regulation of protein catabolic process GO:0042177 13 13 1,000 7,453E-04 0,01002684 ! cell aging GO:0007569 13 13 1,000 7,453E-04 9,954E-03 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 1,000 7,453E-04 9,883E-03 ! response to endoplasmic reticulum stress GO:0034976 13 13 1,000 7,453E-04 9,812E-03 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 7,453E-04 9,742E-03 ! regulation of cell-substrate adhesion GO:0010810 14 13 1,000 7,453E-04 9,674E-03 GO:0001952|regulation of cell-matrix adhesion, ! peptidyl-amino acid modification GO:0018193 61 59 2,000 8,216E-04 0,0105895 ! base-excision repair GO:0006284 14 14 1,000 8,679E-04 0,01110778 ! protein amino acid acylation GO:0043543 14 14 1,000 8,679E-04 0,01103118 ! negative regulation of epithelial cell proliferation GO:0050680 14 14 1,000 8,679E-04 0,01095562 ! axonogenesis GO:0007409 66 62 2,000 9,5E-04 0,01191004 ! protein import into nucleus, translocation GO:0000060 15 15 1,000 9,995E-04 0,01244614 ! positive regulation of fibroblast proliferation GO:0048146 15 15 1,000 9,995E-04 0,01236261 ! insulin receptor signaling pathway GO:0008286 17 15 1,000 9,995E-04 0,01228019 ! ER-nuclear signaling pathway GO:0006984 15 15 1,000 9,995E-04 0,01219887 ! response to starvation GO:0042594 15 15 1,000 9,995E-04 0,01211861 ! response to ionizing radiation GO:0010212 16 15 1,000 9,995E-04 0,0120394 ! negative regulation of transcription factor activity GO:0043433 16 15 1,000 9,995E-04 0,01196123 GO:0090048|negative regulation of transcription regulator activity, ! negative regulation of cell activation GO:0050866 15 15 1,000 9,995E-04 0,01188406 ! protein homooligomerization GO:0051260 15 15 1,000 9,995E-04 0,01180788 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 1,14E-03 0,01338281 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 1,000 1,14E-03 0,01329811 ! segmentation GO:0035282 17 16 1,000 1,14E-03 0,01321448 ! cellular response to nutrient levels GO:0031669 16 16 1,000 1,14E-03 0,01313189 ! positive regulation of catabolic process GO:0009896 16 16 1,000 1,14E-03 0,01305032 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 2,000 1,191E-03 0,01354808 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! striated muscle tissue development GO:0014706 69 67 2,000 1,191E-03 0,01346496 ! negative regulation of cell differentiation GO:0045596 68 67 2,000 1,191E-03 0,01338286 ! response to radiation GO:0009314 70 68 2,000 1,243E-03 0,01388689 ! myelination GO:0042552 17 17 1,000 1,29E-03 0,01431712 ! embryonic skeletal system morphogenesis GO:0048704 17 17 1,000 1,29E-03 0,01423138 ! negative regulation of cell development GO:0010721 18 17 1,000 1,29E-03 0,01414667 GO:0050768|negative regulation of neurogenesis, ! regulation of oxidoreductase activity GO:0051341 17 17 1,000 1,29E-03 0,01406297 ! regulation of osteoblast differentiation GO:0045667 17 17 1,000 1,29E-03 0,01398024 ! regionalization GO:0003002 70 69 2,000 1,297E-03 0,01397973 ! positive regulation of transport GO:0051050 71 70 2,000 1,352E-03 0,01449073 ! cell part morphogenesis GO:0032990 75 70 2,000 1,352E-03 0,01440697 ! muscle tissue development GO:0060537 72 70 2,000 1,352E-03 0,01432417 ! regulation of cell migration GO:0030334 71 71 2,000 1,409E-03 0,0148399 ! regulation of cellular catabolic process GO:0031329 18 18 1,000 1,448E-03 0,01516221 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 1,000 1,448E-03 0,01507655 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 1,448E-03 0,01499185 ! negative regulation of DNA binding GO:0043392 19 18 1,000 1,448E-03 0,01490809 ! B cell differentiation GO:0030183 18 18 1,000 1,448E-03 0,01482527 ! cellular response to extracellular stimulus GO:0031668 18 18 1,000 1,448E-03 0,01474336 ! ensheathment of neurons GO:0007272 18 18 1,000 1,448E-03 0,01466236 GO:0008366|axon ensheathment, ! negative regulation of catabolic process GO:0009895 18 18 1,000 1,448E-03 0,01458223 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 1,000 1,448E-03 0,01450298 ! DNA damage checkpoint GO:0000077 19 19 1,000 1,615E-03 0,01609041 ! negative regulation of DNA metabolic process GO:0051053 19 19 1,000 1,615E-03 0,01600391 ! regulation of pH GO:0006885 19 19 1,000 1,615E-03 0,01591832 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 1,615E-03 0,01583365 ! peripheral nervous system development GO:0007422 19 19 1,000 1,615E-03 0,01574988 ! regulation of protein stability GO:0031647 19 19 1,000 1,615E-03 0,01566698 ! dorsal/ventral pattern formation GO:0009953 19 19 1,000 1,615E-03 0,01558496 ! negative regulation of binding GO:0051100 21 20 1,000 1,791E-03 0,01719311 ! positive regulation of gene-specific transcription GO:0043193 20 20 1,000 1,791E-03 0,01710403 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 1,791E-03 0,01701586 ! regulation of locomotion GO:0040012 79 79 2,000 1,918E-03 0,01812375 ! regulation of cell motion GO:0051270 79 79 2,000 1,918E-03 0,01803128 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 1,000 1,976E-03 0,01848479 ! mammary gland development GO:0030879 23 21 1,000 1,976E-03 0,01839143 ! DNA integrity checkpoint GO:0031570 21 21 1,000 1,976E-03 0,01829901 ! regulation of action potential in neuron GO:0019228 21 21 1,000 1,976E-03 0,01820752 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 1,976E-03 0,01811693 ! cellular response to insulin stimulus GO:0032869 23 21 1,000 1,976E-03 0,01802724 ! negative regulation of protein transport GO:0051224 21 21 1,000 1,976E-03 0,01793844 ! neuron projection development GO:0031175 85 80 2,000 1,988E-03 0,01796192 ! MAPKKK cascade GO:0000165 82 81 2,000 2,06E-03 0,01852339 ! lymphocyte activation GO:0046649 82 81 2,000 2,06E-03 0,01843347 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 2,169E-03 0,01931357 GO:0090047|positive regulation of transcription regulator activity, ! positive regulation of DNA metabolic process GO:0051054 23 22 1,000 2,169E-03 0,01922071 ! embryonic skeletal system development GO:0048706 22 22 1,000 2,169E-03 0,01912875 ! maintenance of protein location in cell GO:0032507 23 22 1,000 2,169E-03 0,01903766 ! regulation of cellular localization GO:0060341 86 85 2,000 2,366E-03 0,02066191 ! mitotic cell cycle checkpoint GO:0007093 24 23 1,000 2,371E-03 0,02061413 ! positive regulation of growth GO:0045927 23 23 1,000 2,371E-03 0,02051735 ! monovalent inorganic cation homeostasis GO:0055067 23 23 1,000 2,371E-03 0,02042148 ! calcium-mediated signaling GO:0019722 23 23 1,000 2,371E-03 0,02032649 ! mitochondrial transport GO:0006839 24 24 1,000 2,582E-03 0,02202903 ! regulation of action potential GO:0001508 24 24 1,000 2,582E-03 0,02192752 ! gliogenesis GO:0042063 24 24 1,000 2,582E-03 0,02182693 ! glucose homeostasis GO:0042593 24 24 1,000 2,582E-03 0,02172727 GO:0033500|carbohydrate homeostasis, ! maintenance of protein location GO:0045185 25 24 1,000 2,582E-03 0,02162851 ! androgen receptor signaling pathway GO:0030521 24 24 1,000 2,582E-03 0,02153064 ! endosome transport GO:0016197 25 25 1,000 2,801E-03 0,02325242 ! regulation of T cell proliferation GO:0042129 25 25 1,000 2,801E-03 0,02314815 ! positive regulation of DNA binding GO:0043388 26 25 1,000 2,801E-03 0,02304481 ! heart morphogenesis GO:0003007 25 25 1,000 2,801E-03 0,02294239 ! negative regulation of immune system process GO:0002683 25 25 1,000 2,801E-03 0,02284087 ! negative regulation of cell cycle GO:0045786 92 91 2,000 2,874E-03 0,02333093 ! positive regulation of binding GO:0051099 27 26 1,000 3,028E-03 0,02447983 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 1,000 3,028E-03 0,02437293 ! induction of apoptosis by intracellular signals GO:0008629 26 26 1,000 3,028E-03 0,02426696 ! regulation of T cell differentiation GO:0045580 26 26 1,000 3,028E-03 0,02416191 ! double-strand break repair GO:0006302 27 26 1,000 3,028E-03 0,02405776 ! response to insulin stimulus GO:0032868 28 26 1,000 3,028E-03 0,02395451 ! maintenance of location in cell GO:0051651 27 26 1,000 3,028E-03 0,02385214 ! synapse organization GO:0050808 26 26 1,000 3,028E-03 0,02375064 ! pattern specification process GO:0007389 96 94 2,000 3,151E-03 0,0246079 ! learning or memory GO:0007611 28 27 1,000 3,264E-03 0,02538509 ! cAMP-mediated signaling GO:0019933 27 27 1,000 3,264E-03 0,02527843 ! activation of caspase activity GO:0006919 27 27 1,000 3,264E-03 0,02517266 ! mesenchymal cell development GO:0014031 29 27 1,000 3,264E-03 0,02506777 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! histone modification GO:0016570 28 28 1,000 3,509E-03 0,02683211 ! regulation of mast cell proliferation GO:0070666 28 28 1,000 3,509E-03 0,02672123 ! glycoprotein metabolic process GO:0009100 99 98 2,000 3,546E-03 0,02689407 ! muscle organ development GO:0007517 102 100 2,000 3,754E-03 0,02835753 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 2,000 3,754E-03 0,02824178 ! positive regulation of cell cycle GO:0045787 29 29 1,000 3,761E-03 0,02817937 ! viral reproductive process GO:0022415 29 29 1,000 3,761E-03 0,02806528 ! regulation of lymphocyte proliferation GO:0050670 29 29 1,000 3,761E-03 0,02795211 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! covalent chromatin modification GO:0016569 29 29 1,000 3,761E-03 0,02783986 ! positive regulation of peptidase activity GO:0010952 30 30 1,000 4,022E-03 0,02965172 GO:0043280|positive regulation of caspase activity, ! activation of phospholipase C activity GO:0007202 30 30 1,000 4,022E-03 0,02953359 GO:0010863|positive regulation of phospholipase C activity, ! skeletal system morphogenesis GO:0048705 31 30 1,000 4,022E-03 0,02941639 ! regulation of ossification GO:0030278 30 30 1,000 4,022E-03 0,02930012 ! skeletal muscle fiber development GO:0048741 31 31 1,000 4,291E-03 0,03113726 ! B cell activation GO:0042113 31 31 1,000 4,291E-03 0,03101516 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 4,291E-03 0,030894 ! aging GO:0007568 32 31 1,000 4,291E-03 0,03077379 ! regulation of myeloid cell differentiation GO:0045637 32 31 1,000 4,291E-03 0,03065451 ! negative regulation of cell growth GO:0030308 32 32 1,000 4,569E-03 0,03250901 ! muscle fiber development GO:0048747 32 32 1,000 4,569E-03 0,03238397 ! regulation of phospholipase activity GO:0010517 32 32 1,000 4,569E-03 0,0322599 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 1,000 4,569E-03 0,03213677 ! regulation of lymphocyte differentiation GO:0045619 32 32 1,000 4,569E-03 0,03201457 ! positive regulation of lipase activity GO:0060193 32 32 1,000 4,569E-03 0,03189331 ! maintenance of location GO:0051235 33 32 1,000 4,569E-03 0,03177296 ! negative regulation of cell size GO:0045792 33 33 1,000 4,854E-03 0,03363062 ! activation of protein kinase activity GO:0032147 35 33 1,000 4,854E-03 0,03350466 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 4,854E-03 0,03337964 ! regulation of angiogenesis GO:0045765 35 34 1,000 5,147E-03 0,03526582 ! regulation of bone remodeling GO:0046850 34 34 1,000 5,147E-03 0,03513521 ! regulation of protein catabolic process GO:0042176 35 34 1,000 5,147E-03 0,03500556 ! response to peptide hormone stimulus GO:0043434 36 34 1,000 5,147E-03 0,03487686 ! viral reproduction GO:0016032 34 34 1,000 5,147E-03 0,03474911 ! positive regulation of phosphorylation GO:0042327 35 35 1,000 5,449E-03 0,03664973 ! regulation of tissue remodeling GO:0034103 35 35 1,000 5,449E-03 0,03651646 ! positive regulation of phosphorus metabolic process GO:0010562 36 36 1,000 5,758E-03 0,03845005 GO:0045937|positive regulation of phosphate metabolic process, ! integrin-mediated signaling pathway GO:0007229 36 36 1,000 5,758E-03 0,03831124 ! regulation of lipase activity GO:0060191 36 36 1,000 5,758E-03 0,03817343 ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 6,075E-03 0,04013255 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! response to drug GO:0042493 37 37 1,000 6,075E-03 0,03998922 ! lung development GO:0030324 38 37 1,000 6,075E-03 0,03984691 ! negative regulation of growth GO:0045926 37 37 1,000 6,075E-03 0,0397056 ! DNA damage response, signal transduction GO:0042770 37 37 1,000 6,075E-03 0,0395653 ! cell-matrix adhesion GO:0007160 39 38 1,000 6,401E-03 0,04153603 ! chromosome segregation GO:0007059 38 38 1,000 6,401E-03 0,04139029 ! steroid hormone receptor signaling pathway GO:0030518 38 38 1,000 6,401E-03 0,04124557 ! regulation of homeostatic process GO:0032844 38 38 1,000 6,401E-03 0,04110186 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 6,734E-03 0,04308987 ! activation of MAPK activity GO:0000187 39 39 1,000 6,734E-03 0,04294077 ! respiratory tube development GO:0030323 40 39 1,000 6,734E-03 0,0427927 ! nucleotide-excision repair GO:0006289 40 39 1,000 6,734E-03 0,04264565 ! respiratory system development GO:0060541 40 39 1,000 6,734E-03 0,0424996 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 7,074E-03 0,04449775 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 1,000 7,074E-03 0,0443464 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 7,423E-03 0,04637293 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cell cycle checkpoint GO:0000075 42 41 1,000 7,423E-03 0,04621627 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 7,779E-03 0,04827044 ! cell-substrate adhesion GO:0031589 43 42 1,000 7,779E-03 0,04810846 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 1,000 8,143E-03 0,05018952 ! mitochondrion organization GO:0007005 44 43 1,000 8,143E-03 0,05002222 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 8,143E-03 0,04985603 ! protein import into nucleus GO:0006606 44 44 1,000 8,514E-03 0,05195684 ! homophilic cell adhesion GO:0007156 45 45 1,000 8,893E-03 0,05408954 ! phosphoinositide-mediated signaling GO:0048015 45 45 1,000 8,893E-03 0,05391161 ! nuclear import GO:0051170 45 45 1,000 8,893E-03 0,05373485 ! Wnt receptor signaling pathway GO:0016055 46 45 1,000 8,893E-03 0,05355925 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 1,000 9,279E-03 0,05570382 ! cellular response to hormone stimulus GO:0032870 48 46 1,000 9,279E-03 0,05552296 ! regulation of membrane potential GO:0042391 46 46 1,000 9,279E-03 0,05534327 ! actin filament organization GO:0007015 50 48 1,000 0,01007376 0,05989014 ! protein localization in nucleus GO:0034504 48 48 1,000 0,01007376 0,05969757 ! ossification GO:0001503 50 49 1,000 0,0104822 0,06191891 GO:0060348|bone development, ! gland development GO:0048732 51 49 1,000 0,0104822 0,06172108 ! negative regulation of transport GO:0051051 51 50 1,000 0,01089793 0,06396461 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 1,000 0,01089793 0,06376155 ! regulation of neurogenesis GO:0050767 51 50 1,000 0,01089793 0,06355977 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 1,000 0,01175107 0,06831931 ! cell fate commitment GO:0045165 52 52 1,000 0,01175107 0,06810447 ! response to hypoxia GO:0001666 53 53 1,000 0,01218839 0,07041755 ! regulation of T cell activation GO:0050863 53 53 1,000 0,01218839 0,07019749 ! response to oxygen levels GO:0070482 55 54 1,000 0,01263281 0,07253042 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 0,01308429 0,07488926 ! in utero embryonic development GO:0001701 55 55 1,000 0,01308429 0,07465741 ! reproductive developmental process GO:0003006 56 56 1,000 0,01354278 0,07703502 ! extracellular structure organization GO:0043062 56 56 1,000 0,01354278 0,07679799 ! regulation of nervous system development GO:0051960 57 56 1,000 0,01354278 0,07656241 ! regulation of cell development GO:0060284 60 59 1,000 0,01495989 0,08431521 ! protein localization in organelle GO:0033365 59 59 1,000 0,01495989 0,08405815 ! rRNA transcription GO:0009303 5 5 0,000 0,01589104 0,08901879 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,01589104 0,08874904 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,01589104 0,08848092 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,01589104 0,08821441 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,01589104 0,0879495 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,01589104 0,08768618 ! reproductive cellular process GO:0048610 5 5 0,000 0,01589104 0,08742443 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,01589104 0,08716423 ! prostate gland development GO:0030850 5 5 0,000 0,01589104 0,08690559 ! metencephalon development GO:0022037 5 5 0,000 0,01589104 0,08664847 ! water transport GO:0006833 5 5 0,000 0,01589104 0,08639287 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,01589104 0,08613877 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,01589104 0,08588617 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,01589104 0,08563504 ! glycerol metabolic process GO:0006071 5 5 0,000 0,01589104 0,08538537 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,01589104 0,08513716 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,01589104 0,08489039 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,01589104 0,08464504 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,01589104 0,0844011 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,01589104 0,08415857 ! filopodium assembly GO:0046847 7 5 0,000 0,01589104 0,08391743 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,01589104 0,08367767 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,01589104 0,08343927 ! GTP metabolic process GO:0046039 5 5 0,000 0,01589104 0,08320222 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,01589104 0,08296652 ! mRNA stabilization GO:0048255 5 5 0,000 0,01589104 0,08273216 GO:0043489|RNA stabilization, ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,01589104 0,08249911 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,01589104 0,08226737 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,01589104 0,08203693 ! social behavior GO:0035176 5 5 0,000 0,01589104 0,08180777 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,01589104 0,0815799 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,01589104 0,08135329 ! memory GO:0007613 5 5 0,000 0,01589104 0,08112793 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,01589104 0,08090382 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,01589104 0,08068094 ! response to lipid GO:0033993 5 5 0,000 0,01589104 0,08045929 ! erythrocyte maturation GO:0043249 5 5 0,000 0,01589104 0,08023886 ! hippocampus development GO:0021766 6 5 0,000 0,01589104 0,08001963 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,01589104 0,07980159 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,01589104 0,07958474 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,01589104 0,07936906 ! mechanosensory behavior GO:0007638 5 5 0,000 0,01589104 0,07915455 ! heart looping GO:0001947 5 5 0,000 0,01589104 0,07894119 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,01589104 0,07872899 ! response to interferon-gamma GO:0034341 5 5 0,000 0,01589104 0,07851792 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,01589104 0,07830798 ! endocrine pancreas development GO:0031018 5 5 0,000 0,01589104 0,07809915 ! pH reduction GO:0045851 5 5 0,000 0,01589104 0,07789144 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,01589104 0,07768484 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,01589104 0,07747932 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,01589104 0,07727489 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,01589104 0,07707153 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,01589104 0,07686925 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,01589104 0,07666802 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,01589104 0,07646784 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,01589104 0,07626871 ! adrenal gland development GO:0030325 5 5 0,000 0,01589104 0,0760706 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,01589104 0,07587353 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,01589104 0,07567748 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,01589104 0,07548243 ! astrocyte differentiation GO:0048708 5 5 0,000 0,01589104 0,07528839 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,01589104 0,07509534 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,01589104 0,07490328 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,01589104 0,0747122 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,01589104 0,07452209 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,01589104 0,07433295 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,01589104 0,07414477 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,01589104 0,07395753 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,01589104 0,07377124 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,01589104 0,07358589 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,01589104 0,07340146 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,01589104 0,07321796 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,01589104 0,07303537 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,01589104 0,07285369 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,01589104 0,07267291 ! response to ATP GO:0033198 5 5 0,000 0,01589104 0,07249303 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,01589104 0,07231403 ! regulation of appetite GO:0032098 5 5 0,000 0,01589104 0,07213592 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,01589104 0,07195868 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,01589104 0,07178231 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,01589104 0,0716068 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,01589104 0,07143215 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,01589104 0,07125835 ! fear response GO:0042596 5 5 0,000 0,01589104 0,0710854 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,01589104 0,07091328 ! retinol metabolic process GO:0042572 5 5 0,000 0,01589104 0,07074199 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,01589104 0,07057153 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,01589104 0,07040188 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,01589104 0,07023305 ! parturition GO:0007567 5 5 0,000 0,01589104 0,07006503 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,01589104 0,06989781 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 0,01589104 0,06973139 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,01589104 0,06956576 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,01589104 0,06940091 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,01589104 0,06923684 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,01589104 0,06907354 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,01589104 0,06891102 ! response to UV-B GO:0010224 5 5 0,000 0,01589104 0,06874926 ! oligodendrocyte development GO:0014003 5 5 0,000 0,01589104 0,06858825 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,01589104 0,068428 ! activated T cell proliferation GO:0050798 5 5 0,000 0,01589104 0,06826849 ! interaction with symbiont GO:0051702 5 5 0,000 0,01589104 0,06810973 ! cellular extravasation GO:0045123 5 5 0,000 0,01589104 0,0679517 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,01589104 0,0677944 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,01589104 0,06763784 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,01589104 0,06748199 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,01589104 0,06732686 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,01589104 0,06717244 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,01589104 0,06701873 ! response to amine stimulus GO:0014075 5 5 0,000 0,01589104 0,06686571 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,01589104 0,0667134 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,01589104 0,06656178 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,01589104 0,06641085 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,01589104 0,06626059 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,01589104 0,06611102 ! neuron recognition GO:0008038 5 5 0,000 0,01589104 0,06596212 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,01589104 0,06581389 ! decidualization GO:0046697 5 5 0,000 0,01589104 0,06566633 ! hair follicle maturation GO:0048820 5 5 0,000 0,01589104 0,06551942 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,01589104 0,06537318 ! regulation of mitochondrial membrane potential GO:0051881 5 5 0,000 0,01589104 0,06522758 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,01589104 0,06508263 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,01589104 0,06493832 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,01589104 0,06479465 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,01589104 0,06465162 ! postreplication repair GO:0006301 5 5 0,000 0,01589104 0,06450921 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,01589104 0,06436743 GO:0021517|ventral spinal cord development, ! cellular pigmentation GO:0033059 5 5 0,000 0,01589104 0,06422628 ! histone methylation GO:0016571 5 5 0,000 0,01589104 0,06408574 ! DNA methylation GO:0006306 5 5 0,000 0,01589104 0,06394581 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01589104 0,0638065 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,01589104 0,06366779 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,01589104 0,06352968 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,01589104 0,06339217 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,01589104 0,06325525 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,01589104 0,06311893 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,01589104 0,06298319 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,01589104 0,06284803 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,01589104 0,06271345 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,01589104 0,06257945 ! sterol catabolic process GO:0016127 5 5 0,000 0,01589104 0,06244602 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,01589104 0,06231316 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,01589104 0,06218086 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,01589104 0,06204912 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,01589104 0,06191793 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,01589104 0,06178731 ! zymogen activation GO:0031638 5 5 0,000 0,01589104 0,06165723 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,01589104 0,0615277 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,01589104 0,06139871 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,01589104 0,06127026 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,01589104 0,06114234 ! nucleosome positioning GO:0016584 5 5 0,000 0,01589104 0,06101496 ! regulation of isotype switching GO:0045191 5 5 0,000 0,01589104 0,06088811 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,01589104 0,06076179 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,01589104 0,06063599 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,01589104 0,06051071 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,01589104 0,06038594 ! NADPH regeneration GO:0006740 5 5 0,000 0,01589104 0,06026169 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,01589104 0,06013795 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,01589104 0,06001472 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,01589104 0,05989199 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,01589104 0,05976976 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,01589104 0,05964803 ! sarcomere organization GO:0045214 5 5 0,000 0,01589104 0,05952679 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,01589104 0,05940605 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,01589104 0,0592858 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,01589104 0,05916603 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,01589104 0,05904674 GO:0045622|regulation of T-helper cell differentiation, ! oocyte differentiation GO:0009994 5 5 0,000 0,01589104 0,05892793 GO:0048599|oocyte development, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,01589104 0,0588096 ! regulation of protein homodimerization activity GO:0043496 6 5 0,000 0,01589104 0,05869175 ! spleen development GO:0048536 5 5 0,000 0,01589104 0,05857437 ! male genitalia development GO:0030539 5 5 0,000 0,01589104 0,05845745 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,01589104 0,058341 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,01589104 0,05822502 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,01589104 0,05810949 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,01589104 0,05799442 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,01589104 0,05787981 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,01589104 0,05776565 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,01589104 0,05765193 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,01589104 0,05753867 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,01589104 0,05742585 ! ATP catabolic process GO:0006200 5 5 0,000 0,01589104 0,05731347 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01589104 0,05720153 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,01589104 0,05709003 ! blastocyst formation GO:0001825 5 5 0,000 0,01589104 0,05697896 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,01589104 0,05686832 ! embryonic gut development GO:0048566 5 5 0,000 0,01589104 0,05675811 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,01589104 0,05664832 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,01589104 0,05653896 ! activation of innate immune response GO:0002218 5 5 0,000 0,01589104 0,05643002 GO:0002758|innate immune response-activating signal transduction, ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 0,000 0,01589104 0,05632151 ! catecholamine transport GO:0051937 5 5 0,000 0,01589104 0,0562134 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,01589104 0,05610571 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,01589104 0,05599844 ! muscle adaptation GO:0043500 5 5 0,000 0,01589104 0,05589157 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,01589104 0,05578511 ! embryonic heart tube development GO:0035050 5 5 0,000 0,01589104 0,05567905 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,01589104 0,0555734 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,01589104 0,05546815 ! defense response to fungus GO:0050832 5 5 0,000 0,01589104 0,05536329 ! lysogeny GO:0030069 5 5 0,000 0,01589104 0,05525884 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,01589104 0,05515477 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,01589104 0,0550511 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,01589104 0,05494781 ! response to nicotine GO:0035094 5 5 0,000 0,01589104 0,05484491 ! establishment of cell polarity GO:0030010 5 5 0,000 0,01589104 0,0547424 ! mitochondrion localization GO:0051646 5 5 0,000 0,01589104 0,05464027 ! nucleus localization GO:0051647 5 5 0,000 0,01589104 0,05453852 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,01589104 0,05443714 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 1,000 0,01593887 0,0544997 ! morphogenesis of an epithelium GO:0002009 63 62 1,000 0,0164385 0,05610399 GO:0060429|epithelium development, ! protein import GO:0017038 62 62 1,000 0,0164385 0,05600029 ! regulation of lymphocyte activation GO:0051249 62 62 1,000 0,0164385 0,05589697 ! angiogenesis GO:0001525 65 64 1,000 0,01745782 0,05925371 ! negative regulation of protein metabolic process GO:0051248 66 66 1,000 0,01850359 0,06268773 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,01904019 0,06438727 ! axon extension GO:0048675 7 6 0,000 0,01904019 0,06426935 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,01904019 0,06415185 ! tRNA modification GO:0006400 6 6 0,000 0,01904019 0,06403479 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,01904019 0,06391815 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,01904019 0,06380193 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,01904019 0,06368614 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,01904019 0,06357077 ! regulation of S phase GO:0033261 6 6 0,000 0,01904019 0,06345581 ! myotube differentiation GO:0014902 6 6 0,000 0,01904019 0,06334127 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,01904019 0,06322714 ! bone remodeling GO:0046849 6 6 0,000 0,01904019 0,06311342 ! N-glycan processing GO:0006491 6 6 0,000 0,01904019 0,06300011 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,01904019 0,06288721 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,01904019 0,06277471 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,01904019 0,06266261 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,01904019 0,06255092 ! RNA methylation GO:0001510 6 6 0,000 0,01904019 0,06243962 ! cartilage condensation GO:0001502 7 6 0,000 0,01904019 0,06232871 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,01904019 0,0622182 ! regulation of positive chemotaxis GO:0050926 6 6 0,000 0,01904019 0,06210808 GO:0050927|positive regulation of positive chemotaxis, ! succinate metabolic process GO:0006105 7 6 0,000 0,01904019 0,06199835 ! artery development GO:0060840 6 6 0,000 0,01904019 0,061889 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,01904019 0,06178004 ! bile acid metabolic process GO:0008206 6 6 0,000 0,01904019 0,06167147 ! androgen metabolic process GO:0008209 6 6 0,000 0,01904019 0,06156327 ! estrogen metabolic process GO:0008210 6 6 0,000 0,01904019 0,06145545 ! limbic system development GO:0021761 7 6 0,000 0,01904019 0,06134801 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,01904019 0,06124095 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,01904019 0,06113426 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,01904019 0,06102794 ! pathogenesis GO:0009405 6 6 0,000 0,01904019 0,06092199 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,01904019 0,0608164 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,01904019 0,06071118 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,01904019 0,06060633 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,01904019 0,06050183 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,01904019 0,0603977 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,01904019 0,06029392 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,01904019 0,0601905 ! arginine metabolic process GO:0006525 6 6 0,000 0,01904019 0,06008744 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,01904019 0,05998472 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,01904019 0,05988236 ! glutamate catabolic process GO:0006538 7 6 0,000 0,01904019 0,05978035 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,01904019 0,05967868 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,01904019 0,05957736 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,01904019 0,05947638 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,01904019 0,05937574 ! V(D)J recombination GO:0033151 6 6 0,000 0,01904019 0,05927545 ! focal adhesion formation GO:0048041 7 6 0,000 0,01904019 0,05917549 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,01904019 0,05907587 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,01904019 0,05897658 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,01904019 0,05887762 ! regulation of heart rate GO:0002027 6 6 0,000 0,01904019 0,058779 ! lipid digestion GO:0044241 6 6 0,000 0,01904019 0,05868071 ! asymmetric protein localization GO:0008105 6 6 0,000 0,01904019 0,05858274 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,01904019 0,05848511 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,01904019 0,05838779 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,01904019 0,0582908 ! regulation of vascular permeability GO:0043114 6 6 0,000 0,01904019 0,05819414 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,01904019 0,05809779 ! ruffle organization GO:0031529 6 6 0,000 0,01904019 0,05800176 ! peptidyl-serine phosphorylation GO:0018105 6 6 0,000 0,01904019 0,05790605 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,01904019 0,05781065 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,01904019 0,05771557 ! neutral amino acid transport GO:0015804 6 6 0,000 0,01904019 0,05762079 ! L-amino acid transport GO:0015807 6 6 0,000 0,01904019 0,05752633 ! bone mineralization GO:0030282 6 6 0,000 0,01904019 0,05743218 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,01904019 0,05733834 ! negative regulation of ossification GO:0030279 6 6 0,000 0,01904019 0,0572448 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,01904019 0,05715157 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of bone resorption GO:0045124 6 6 0,000 0,01904019 0,05705864 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,01904019 0,05696601 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,01904019 0,05687369 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,01904019 0,05678166 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,01904019 0,05668993 ! regulation of organ growth GO:0046620 6 6 0,000 0,01904019 0,05659849 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,01904019 0,05650735 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,01904019 0,0564165 ! response to dsRNA GO:0043331 6 6 0,000 0,01904019 0,05632595 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,01904019 0,05623568 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,01904019 0,0561457 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,01904019 0,05605601 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,01904019 0,05596661 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,01904019 0,05587749 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,01904019 0,05578865 ! multicellular organismal aging GO:0010259 6 6 0,000 0,01904019 0,0557001 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,01904019 0,05561183 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,01904019 0,05552384 ! erythrocyte development GO:0048821 6 6 0,000 0,01904019 0,05543612 ! renal water homeostasis GO:0003091 6 6 0,000 0,01904019 0,05534868 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,01904019 0,05526152 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,01904019 0,05517463 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,01904019 0,05508801 ! ribosome assembly GO:0042255 6 6 0,000 0,01904019 0,05500167 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,01904019 0,05491559 ! diencephalon development GO:0021536 6 6 0,000 0,01904019 0,05482979 ! fucose catabolic process GO:0019317 6 6 0,000 0,01904019 0,05474425 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,01904019 0,05465898 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,01904019 0,05457397 ! regulation of lipid transport GO:0032368 6 6 0,000 0,01904019 0,05448923 ! regulation of cell division GO:0051302 6 6 0,000 0,01904019 0,05440475 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,01904019 0,05432053 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,01904019 0,05423657 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,01904019 0,05415288 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,01904019 0,05406944 ! neuroblast proliferation GO:0007405 6 6 0,000 0,01904019 0,05398625 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,01904019 0,05390332 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,01904019 0,05382065 ! regulation of glucose transport GO:0010827 6 6 0,000 0,01904019 0,05373823 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,01904019 0,05365606 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,01904019 0,05357414 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,01904019 0,05349248 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,01904019 0,05341106 ! thymus development GO:0048538 6 6 0,000 0,01904019 0,05332988 ! lymph node development GO:0048535 6 6 0,000 0,01904019 0,05324896 ! organic cation transport GO:0015695 6 6 0,000 0,01904019 0,05316828 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,01904019 0,05308784 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,01904019 0,05300765 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,01904019 0,0529277 ! sperm-egg recognition GO:0035036 7 6 0,000 0,01904019 0,05284799 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,01904019 0,05276852 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,01904019 0,05268929 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,01904019 0,05261029 ! alditol metabolic process GO:0019400 6 6 0,000 0,01904019 0,05253153 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,01904019 0,05245301 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,01904019 0,05237472 ! maternal placenta development GO:0001893 6 6 0,000 0,01904019 0,05229667 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,01904019 0,05221885 ! regulation of cell size GO:0008361 68 68 1,000 0,01957548 0,05360714 ! response to nutrient levels GO:0031667 69 69 1,000 0,0201211 0,05501956 ! regulation of leukocyte activation GO:0002694 69 69 1,000 0,0201211 0,05493805 ! regulation of mitotic cell cycle GO:0007346 72 69 1,000 0,0201211 0,05485678 ! wound healing GO:0042060 74 70 1,000 0,02067312 0,05627853 ! calcium ion homeostasis GO:0055074 71 71 1,000 0,0212315 0,05771335 GO:0006874|cellular calcium ion homeostasis, ! regulation of cell activation GO:0050865 71 71 1,000 0,0212315 0,05762835 ! response to extracellular stimulus GO:0009991 72 72 1,000 0,02179619 0,05907408 ! respiratory burst GO:0045730 7 7 0,000 0,02217971 0,06002528 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,02217971 0,05993726 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,02217971 0,05984951 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,02217971 0,05976201 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,02217971 0,05967477 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,02217971 0,05958778 ! regulation of chemokine production GO:0032642 7 7 0,000 0,02217971 0,05950104 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,02217971 0,05941456 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,02217971 0,05932832 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,02217971 0,05924234 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,02217971 0,05915661 GO:0043241|protein complex disassembly, ! hair follicle morphogenesis GO:0031069 7 7 0,000 0,02217971 0,05907112 ! gene silencing by RNA GO:0031047 7 7 0,000 0,02217971 0,05898588 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,02217971 0,05890088 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,02217971 0,05881614 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,02217971 0,05873163 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,02217971 0,05864737 ! axis specification GO:0009798 7 7 0,000 0,02217971 0,05856334 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,02217971 0,05847956 ! visual behavior GO:0007632 7 7 0,000 0,02217971 0,05839602 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,02217971 0,05831272 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,02217971 0,05822965 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,02217971 0,05814682 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,02217971 0,05806422 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,02217971 0,05798186 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,02217971 0,05789974 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,02217971 0,05781784 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,02217971 0,05773618 ! digestive system development GO:0055123 7 7 0,000 0,02217971 0,05765474 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,02217971 0,05757354 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,02217971 0,05749257 ! protein targeting to ER GO:0045047 8 7 0,000 0,02217971 0,05741182 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,02217971 0,0573313 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,02217971 0,057251 ! endoderm development GO:0007492 7 7 0,000 0,02217971 0,05717093 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,02217971 0,05709108 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,02217971 0,05701146 GO:0006688|glycosphingolipid biosynthetic process, ! regulation of mRNA processing GO:0050684 7 7 0,000 0,02217971 0,05693205 ! response to hexose stimulus GO:0009746 7 7 0,000 0,02217971 0,05685287 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,02217971 0,05677391 ! regulation of skeletal muscle fiber development GO:0048742 7 7 0,000 0,02217971 0,05669517 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,02217971 0,05661664 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,02217971 0,05653833 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,02217971 0,05646024 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,02217971 0,05638236 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,02217971 0,0563047 ! UV protection GO:0009650 7 7 0,000 0,02217971 0,05622725 ! DNA integration GO:0015074 7 7 0,000 0,02217971 0,05615002 ! myofibril assembly GO:0030239 7 7 0,000 0,02217971 0,056073 GO:0055002|striated muscle cell development, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,02217971 0,05599618 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,02217971 0,05591958 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,02217971 0,05584319 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,02217971 0,055767 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,02217971 0,05569103 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,02217971 0,05561526 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,02217971 0,05553969 GO:0019827|stem cell maintenance, ! alpha-beta T cell differentiation GO:0046632 7 7 0,000 0,02217971 0,05546433 ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,02217971 0,05538918 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,02217971 0,05531423 ! axon cargo transport GO:0008088 7 7 0,000 0,02217971 0,05523948 ! eating behavior GO:0042755 7 7 0,000 0,02217971 0,05516493 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,02217971 0,05509059 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,02217971 0,05501644 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,02217971 0,05494249 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,02217971 0,05486874 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,02217971 0,05479519 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,02217971 0,05472184 ! induction of an organ GO:0001759 7 7 0,000 0,02217971 0,05464868 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,02217971 0,05457572 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,02217971 0,05450295 ! intracellular lipid transport GO:0032365 7 7 0,000 0,02217971 0,05443038 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,02217971 0,054358 ! platelet activation GO:0030168 8 7 0,000 0,02217971 0,05428581 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,02217971 0,05421381 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,02217971 0,05414201 ! natural killer cell activation GO:0030101 7 7 0,000 0,02217971 0,05407039 ! NADP metabolic process GO:0006739 7 7 0,000 0,02217971 0,05399896 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,02217971 0,05392772 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,02217971 0,05385667 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,02217971 0,05378581 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,02217971 0,05371513 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,02217971 0,05364464 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,02217971 0,05357433 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,02217971 0,05350421 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,02217971 0,05343427 ! cell-cell recognition GO:0009988 8 7 0,000 0,02217971 0,05336451 ! hormone catabolic process GO:0042447 7 7 0,000 0,02217971 0,05329493 ! dopamine metabolic process GO:0042417 7 7 0,000 0,02217971 0,05322554 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,02217971 0,05315633 ! oxygen transport GO:0015671 7 7 0,000 0,02217971 0,05308729 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,02217971 0,05301844 ! regulation of mRNA stability GO:0043488 7 7 0,000 0,02217971 0,05294976 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,02217971 0,05288126 ! regulation of axon extension GO:0030516 7 7 0,000 0,02217971 0,05281294 ! cell killing GO:0001906 7 7 0,000 0,02217971 0,05274479 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,02217971 0,05267682 ! adult feeding behavior GO:0008343 7 7 0,000 0,02217971 0,05260903 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,02217971 0,05254141 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,02217971 0,05247396 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,02217971 0,05240668 ! response to cold GO:0009409 7 7 0,000 0,02217971 0,05233958 ! cellular metal ion homeostasis GO:0006875 77 77 1,000 0,02471287 0,05824274 ! regulation of skeletal muscle tissue development GO:0048641 8 8 0,000 0,02530965 0,05957303 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,02530965 0,05949705 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,02530965 0,05942125 ! positive regulation of translation GO:0045727 8 8 0,000 0,02530965 0,05934566 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,02530965 0,05927025 ! superoxide anion generation GO:0042554 8 8 0,000 0,02530965 0,05919503 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,02530965 0,05912001 ! cGMP metabolic process GO:0046068 8 8 0,000 0,02530965 0,05904517 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,02530965 0,05897052 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,02530965 0,05889607 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,02530965 0,0588218 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,02530965 0,05874771 ! negative regulation of bone remodeling GO:0046851 8 8 0,000 0,02530965 0,05867382 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,02530965 0,05860011 ! zinc ion transport GO:0006829 8 8 0,000 0,02530965 0,05852658 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,02530965 0,05845324 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,02530965 0,05838008 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,02530965 0,05830711 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,02530965 0,05823431 ! lipid localization GO:0010876 8 8 0,000 0,02530965 0,0581617 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,02530965 0,05808927 ! response to cAMP GO:0051591 8 8 0,000 0,02530965 0,05801702 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,02530965 0,05794495 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,02530965 0,05787306 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,02530965 0,05780134 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,02530965 0,05772981 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,02530965 0,05765845 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,02530965 0,05758727 ! sensory perception of taste GO:0050909 8 8 0,000 0,02530965 0,05751626 ! organelle fusion GO:0048284 8 8 0,000 0,02530965 0,05744543 ! pancreas development GO:0031016 8 8 0,000 0,02530965 0,05737477 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,02530965 0,05730428 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! T cell selection GO:0045058 8 8 0,000 0,02530965 0,05723397 ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,02530965 0,05716383 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,02530965 0,05709386 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,02530965 0,05702406 ! sperm motility GO:0030317 8 8 0,000 0,02530965 0,05695444 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,02530965 0,05688498 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,02530965 0,05681569 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,02530965 0,05674658 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,02530965 0,05667762 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,02530965 0,05660884 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,02530965 0,05654022 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,02530965 0,05647177 ! Golgi organization GO:0007030 8 8 0,000 0,02530965 0,05640349 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,02530965 0,05633537 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,02530965 0,05626741 ! positive regulation of endothelial cell migration GO:0010595 8 8 0,000 0,02530965 0,05619962 ! fructose metabolic process GO:0006000 8 8 0,000 0,02530965 0,05613199 ! mannose metabolic process GO:0006013 9 8 0,000 0,02530965 0,05606453 ! NAD metabolic process GO:0019674 8 8 0,000 0,02530965 0,05599722 ! negative regulation of mitotic cell cycle GO:0045930 9 8 0,000 0,02530965 0,05593008 ! plasma membrane fusion GO:0045026 8 8 0,000 0,02530965 0,0558631 ! response to fungus GO:0009620 8 8 0,000 0,02530965 0,05579627 ! stem cell differentiation GO:0048863 8 8 0,000 0,02530965 0,05572961 ! alpha-beta T cell activation GO:0046631 8 8 0,000 0,02530965 0,05566311 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,02530965 0,05559676 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,02530965 0,05553058 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,02530965 0,05546455 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,02530965 0,05539868 ! regulation of vasodilation GO:0042312 8 8 0,000 0,02530965 0,05533296 ! vasoconstriction GO:0042310 8 8 0,000 0,02530965 0,0552674 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,02530965 0,05520199 ! muscle cell development GO:0055001 8 8 0,000 0,02530965 0,05513674 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,02530965 0,05507165 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,02530965 0,0550067 ! sensory perception of pain GO:0019233 8 8 0,000 0,02530965 0,05494191 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,02530965 0,05487728 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,02530965 0,05481279 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,02530965 0,05474846 ! chromatin silencing GO:0006342 8 8 0,000 0,02530965 0,05468427 ! tissue regeneration GO:0042246 8 8 0,000 0,02530965 0,05462024 ! salivary gland development GO:0007431 8 8 0,000 0,02530965 0,05455636 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,02530965 0,05449262 ! T cell homeostasis GO:0043029 8 8 0,000 0,02530965 0,05442904 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,02530965 0,0543656 ! peptidyl-serine modification GO:0018209 8 8 0,000 0,02530965 0,05430231 ! water homeostasis GO:0030104 8 8 0,000 0,02530965 0,05423917 ! cofactor transport GO:0051181 8 8 0,000 0,02530965 0,05417617 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,02530965 0,05411332 ! acid secretion GO:0046717 8 8 0,000 0,02530965 0,05405062 ! positive regulation of leukocyte migration GO:0002687 8 8 0,000 0,02530965 0,05398806 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,02530965 0,05392565 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,02530965 0,05386338 ! regulation of immunoglobulin production GO:0002637 8 8 0,000 0,02530965 0,05380125 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,02530965 0,05373927 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,02530965 0,05367743 ! regulation of RNA stability GO:0043487 8 8 0,000 0,02530965 0,05361573 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,02530965 0,05355417 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,02530965 0,05349276 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,02530965 0,05343148 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,02530965 0,05337035 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,02530965 0,05330935 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,02530965 0,0532485 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,02530965 0,05318778 ! developmental induction GO:0031128 8 8 0,000 0,02530965 0,0531272 GO:0045168|cell-cell signaling involved in cell fate specification, ! peptide hormone secretion GO:0030072 8 8 0,000 0,02530965 0,05306676 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,02530965 0,05300646 ! actin filament polymerization GO:0030041 9 8 0,000 0,02530965 0,05294629 ! peptide hormone processing GO:0016486 8 8 0,000 0,02530965 0,05288626 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,02530965 0,05282637 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,02530965 0,05276661 ! regulation of protein modification process GO:0031399 79 78 1,000 0,02531456 0,05271722 ! positive regulation of protein kinase cascade GO:0010740 79 78 1,000 0,02531456 0,05265772 ! metal ion homeostasis GO:0055065 78 78 1,000 0,02531456 0,05259835 ! nuclear transport GO:0051169 79 79 1,000 0,02592228 0,0538004 GO:0006913|nucleocytoplasmic transport, ! tube development GO:0035295 83 81 1,000 0,02715561 0,05629672 ! blood vessel morphogenesis GO:0048514 84 83 1,000 0,02841254 0,0588363 ! lactation GO:0007595 10 9 0,000 0,02843002 0,05880643 ! embryonic pattern specification GO:0009880 10 9 0,000 0,02843002 0,0587405 ! positive regulation of cell size GO:0045793 9 9 0,000 0,02843002 0,05867472 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,02843002 0,05860909 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,02843002 0,05854361 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,02843002 0,05847827 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,02843002 0,05841308 ! negative regulation of cell cycle process GO:0010948 9 9 0,000 0,02843002 0,05834803 ! viral genome replication GO:0019079 9 9 0,000 0,02843002 0,05828312 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,02843002 0,05821836 ! copper ion transport GO:0006825 9 9 0,000 0,02843002 0,05815375 ! lipid phosphorylation GO:0046834 9 9 0,000 0,02843002 0,05808928 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,02843002 0,05802495 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,02843002 0,05796076 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,02843002 0,05789672 ! RNA polyadenylation GO:0043631 9 9 0,000 0,02843002 0,05783281 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,02843002 0,05776905 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,02843002 0,05770543 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,02843002 0,05764195 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,02843002 0,0575786 ! phospholipid efflux GO:0033700 9 9 0,000 0,02843002 0,0575154 ! response to alkaloid GO:0043279 10 9 0,000 0,02843002 0,05745233 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,02843002 0,05738941 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,02843002 0,05732662 GO:0042107|cytokine metabolic process, ! positive regulation of endothelial cell proliferation GO:0001938 9 9 0,000 0,02843002 0,05726397 ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,02843002 0,05720145 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,02843002 0,05713907 ! response to ethanol GO:0045471 9 9 0,000 0,02843002 0,05707683 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 0,000 0,02843002 0,05701472 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,02843002 0,05695275 ! activation of pro-apoptotic gene products GO:0008633 9 9 0,000 0,02843002 0,05689091 ! methionine metabolic process GO:0006555 9 9 0,000 0,02843002 0,05682921 ! glutamine metabolic process GO:0006541 9 9 0,000 0,02843002 0,05676764 ! cerebral cortex development GO:0021987 9 9 0,000 0,02843002 0,0567062 ! response to osmotic stress GO:0006970 9 9 0,000 0,02843002 0,0566449 ! pigmentation during development GO:0048066 9 9 0,000 0,02843002 0,05658372 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,02843002 0,05652268 ! central nervous system neuron development GO:0021954 10 9 0,000 0,02843002 0,05646178 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,02843002 0,056401 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,02843002 0,05634035 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,02843002 0,05627984 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,02843002 0,05621945 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 0,000 0,02843002 0,05615919 GO:0060675|ureteric bud morphogenesis, ! L-glutamate transport GO:0015813 9 9 0,000 0,02843002 0,05609907 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,02843002 0,05603907 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,02843002 0,0559792 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,02843002 0,05591945 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,02843002 0,05585984 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,02843002 0,05580035 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,02843002 0,05574099 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,02843002 0,05568175 ! DNA replication initiation GO:0006270 9 9 0,000 0,02843002 0,05562264 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,02843002 0,05556366 GO:0006692|prostanoid metabolic process, ! T cell differentiation in the thymus GO:0033077 9 9 0,000 0,02843002 0,0555048 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,02843002 0,05544606 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,02843002 0,05538745 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,02843002 0,05532896 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,02843002 0,0552706 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,02843002 0,05521236 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,02843002 0,05515424 ! negative regulation of tissue remodeling GO:0034104 9 9 0,000 0,02843002 0,05509624 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,02843002 0,05503837 ! regulation of leukocyte migration GO:0002685 9 9 0,000 0,02843002 0,05498062 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,02843002 0,05492299 ! collagen catabolic process GO:0030574 9 9 0,000 0,02843002 0,05486547 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,02843002 0,05480808 ! purine base metabolic process GO:0006144 9 9 0,000 0,02843002 0,05475081 ! gas transport GO:0015669 9 9 0,000 0,02843002 0,05469366 ! cholesterol efflux GO:0033344 9 9 0,000 0,02843002 0,05463663 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,02843002 0,05457972 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,02843002 0,05452292 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,02843002 0,05446625 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,02843002 0,05440969 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 0,000 0,02843002 0,05435325 ! defense response to virus GO:0051607 9 9 0,000 0,02843002 0,05429692 ! actin filament-based movement GO:0030048 9 9 0,000 0,02843002 0,05424071 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,02843002 0,05418462 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 1,000 0,03034148 0,05776791 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,03154085 0,05998947 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,03154085 0,05992762 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,03154085 0,05986591 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,03154085 0,05980432 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,03154085 0,05974285 ! neuron maturation GO:0042551 10 10 0,000 0,03154085 0,05968151 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,03154085 0,0596203 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,03154085 0,05955922 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,03154085 0,05949826 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,03154085 0,05943742 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,03154085 0,05937671 ! hormone secretion GO:0046879 10 10 0,000 0,03154085 0,05931612 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,03154085 0,05925565 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,03154085 0,05919531 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 0,000 0,03154085 0,05913509 ! inositol metabolic process GO:0006020 10 10 0,000 0,03154085 0,059075 ! cAMP metabolic process GO:0046058 10 10 0,000 0,03154085 0,05901502 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,03154085 0,05895517 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,03154085 0,05889544 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,03154085 0,05883583 ! glial cell development GO:0021782 10 10 0,000 0,03154085 0,05877633 ! phototransduction GO:0007602 11 10 0,000 0,03154085 0,05871696 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,03154085 0,05865771 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,03154085 0,05859858 ! fat cell differentiation GO:0045444 10 10 0,000 0,03154085 0,05853957 ! myoblast differentiation GO:0045445 10 10 0,000 0,03154085 0,05848068 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,03154085 0,0584219 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,03154085 0,05836325 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,03154085 0,05830471 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,03154085 0,05824629 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,03154085 0,05818798 ! epidermis morphogenesis GO:0048730 10 10 0,000 0,03154085 0,0581298 ! protein polyubiquitination GO:0000209 10 10 0,000 0,03154085 0,05807172 ! glutamate metabolic process GO:0006536 11 10 0,000 0,03154085 0,05801377 ! plasma membrane organization GO:0007009 10 10 0,000 0,03154085 0,05795593 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,03154085 0,0578982 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cell-substrate junction assembly GO:0007044 11 10 0,000 0,03154085 0,05784059 ! lysosomal transport GO:0007041 10 10 0,000 0,03154085 0,0577831 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,03154085 0,05772572 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,03154085 0,05766845 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,03154085 0,05761129 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,03154085 0,05755425 ! exocrine system development GO:0035272 10 10 0,000 0,03154085 0,05749732 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,03154085 0,05744051 ! embryo implantation GO:0007566 11 10 0,000 0,03154085 0,05738381 ! regulation of protein binding GO:0043393 11 10 0,000 0,03154085 0,05732721 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,03154085 0,05727073 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,03154085 0,05721437 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,03154085 0,05715811 ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,03154085 0,05710196 ! protein export from nucleus GO:0006611 10 10 0,000 0,03154085 0,05704592 ! negative regulation of immune response GO:0050777 10 10 0,000 0,03154085 0,05699 ! cytolysis GO:0019835 10 10 0,000 0,03154085 0,05693418 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,03154085 0,05687847 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,03154085 0,05682287 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,03154085 0,05676738 ! histone deacetylation GO:0016575 10 10 0,000 0,03154085 0,056712 ! mRNA splice site selection GO:0006376 11 10 0,000 0,03154085 0,05665672 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,03154085 0,05660155 ! gland morphogenesis GO:0022612 10 10 0,000 0,03154085 0,05654649 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,03154085 0,05649154 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,03154085 0,05643669 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,03154085 0,05638195 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,03154085 0,05632732 ! regulation of epidermis development GO:0045682 10 10 0,000 0,03154085 0,05627279 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,03154085 0,05621837 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,03154085 0,05616405 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,03154085 0,05610984 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,03154085 0,05605573 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,03154085 0,05600173 ! lymphocyte homeostasis GO:0002260 10 10 0,000 0,03154085 0,05594783 ! gut development GO:0048565 10 10 0,000 0,03154085 0,05589403 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,03154085 0,05584034 ! negative regulation of homeostatic process GO:0032845 10 10 0,000 0,03154085 0,05578675 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,03154085 0,05573326 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,03154085 0,05567988 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,03154085 0,0556266 ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 1,000 0,03232172 0,05694926 ! brain development GO:0007420 91 90 1,000 0,03299301 0,05807653 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 1,000 0,03366985 0,05921139 ! DNA replication GO:0006260 91 91 1,000 0,03366985 0,05915495 ! protein secretion GO:0009306 11 11 0,000 0,03464218 0,06080527 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,03464218 0,06074742 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,03464218 0,06068967 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,03464218 0,06063204 ! negative regulation of defense response GO:0031348 11 11 0,000 0,03464218 0,06057451 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,03464218 0,0605171 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,03464218 0,06045979 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,03464218 0,06040259 ! skin development GO:0043588 11 11 0,000 0,03464218 0,0603455 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,03464218 0,06028851 ! microtubule-based transport GO:0010970 11 11 0,000 0,03464218 0,06023164 ! endothelial cell migration GO:0043542 11 11 0,000 0,03464218 0,06017487 ! peroxisomal transport GO:0043574 11 11 0,000 0,03464218 0,06011821 ! protein amino acid methylation GO:0006479 11 11 0,000 0,03464218 0,06006165 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,03464218 0,0600052 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,03464218 0,05994886 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,03464218 0,05989262 ! T cell proliferation GO:0042098 11 11 0,000 0,03464218 0,05983649 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,03464218 0,05978047 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,03464218 0,05972454 ! regulation of viral genome replication GO:0045069 11 11 0,000 0,03464218 0,05966873 ! spinal cord development GO:0021510 11 11 0,000 0,03464218 0,05961301 ! smooth muscle contraction GO:0006939 11 11 0,000 0,03464218 0,0595574 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,03464218 0,0595019 ! digestive system process GO:0022600 11 11 0,000 0,03464218 0,0594465 ! mitotic spindle organization GO:0007052 11 11 0,000 0,03464218 0,0593912 ! fucose metabolic process GO:0006004 11 11 0,000 0,03464218 0,059336 ! membrane budding GO:0006900 11 11 0,000 0,03464218 0,05928091 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,03464218 0,05922592 ! monoamine transport GO:0015844 11 11 0,000 0,03464218 0,05917103 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,03464218 0,05911624 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,03464218 0,05906155 ! body fluid secretion GO:0007589 11 11 0,000 0,03464218 0,05900697 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 0,000 0,03464218 0,05895248 ! intermediate filament-based process GO:0045103 11 11 0,000 0,03464218 0,0588981 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,03464218 0,05884381 GO:0060415|muscle tissue morphogenesis, ! membrane depolarization GO:0051899 11 11 0,000 0,03464218 0,05878963 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,03464218 0,05873554 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,03464218 0,05868156 ! oogenesis GO:0048477 11 11 0,000 0,03464218 0,05862767 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,03464218 0,05857389 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,03464218 0,0585202 ! vitamin transport GO:0051180 11 11 0,000 0,03464218 0,05846661 ! muscle maintenance GO:0046716 12 11 0,000 0,03464218 0,05841312 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,03464218 0,05835972 ! steroid catabolic process GO:0006706 11 11 0,000 0,03464218 0,05830643 ! endocrine process GO:0050886 11 11 0,000 0,03464218 0,05825323 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,03464218 0,05820012 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,03464218 0,05814712 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,03464218 0,05809421 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,03464218 0,0580414 ! tissue morphogenesis GO:0048729 94 93 1,000 0,03504001 0,05865462 ! blood vessel development GO:0001568 95 94 1,000 0,03573324 0,05976077 ! regulation of cell growth GO:0001558 97 96 1,000 0,03713585 0,0620502 ! vasculature development GO:0001944 97 96 1,000 0,03713585 0,06199399 ! positive regulation of protein catabolic process GO:0045732 12 12 0,000 0,03773402 0,06293557 ! translational initiation GO:0006413 12 12 0,000 0,03773402 0,06287867 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,03773402 0,06282186 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,03773402 0,06276517 ! initiation of viral infection GO:0019059 12 12 0,000 0,03773402 0,06270857 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,03773402 0,06265208 ! iron ion transport GO:0006826 13 12 0,000 0,03773402 0,06259568 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,03773402 0,06253939 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,03773402 0,0624832 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,03773402 0,06242711 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,03773402 0,06237112 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,03773402 0,06231524 ! collagen metabolic process GO:0032963 12 12 0,000 0,03773402 0,06225945 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,03773402 0,06220376 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,03773402 0,06214817 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,03773402 0,06209268 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,03773402 0,06203729 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,03773402 0,061982 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,03773402 0,06192681 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,03773402 0,06187171 ! actomyosin structure organization GO:0031032 12 12 0,000 0,03773402 0,06181671 ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,03773402 0,06176182 ! retinoid metabolic process GO:0001523 12 12 0,000 0,03773402 0,06170701 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,03773402 0,06165231 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,03773402 0,0615977 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,03773402 0,06154319 GO:0006505|GPI anchor metabolic process, ! acute-phase response GO:0006953 12 12 0,000 0,03773402 0,06148877 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,03773402 0,06143446 ! vacuolar transport GO:0007034 12 12 0,000 0,03773402 0,06138023 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,03773402 0,06132611 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,03773402 0,06127207 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,03773402 0,06121814 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,03773402 0,0611643 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,03773402 0,06111055 ! male gonad development GO:0008584 12 12 0,000 0,03773402 0,0610569 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,03773402 0,06100334 ! regulation of alpha-beta T cell activation GO:0046634 12 12 0,000 0,03773402 0,06094987 ! renal system process GO:0003014 12 12 0,000 0,03773402 0,0608965 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,03773402 0,06084322 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,03773402 0,06079004 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,03773402 0,06073695 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,03773402 0,06068395 ! pallium development GO:0021543 13 12 0,000 0,03773402 0,06063104 ! cell fate determination GO:0001709 12 12 0,000 0,03773402 0,06057823 ! regulation of chromosome organization GO:0033044 12 12 0,000 0,03773402 0,0605255 ! positive regulation of multicellular organism growth GO:0040018 12 12 0,000 0,03773402 0,06047287 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,03773402 0,06042033 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,03773402 0,06036789 ! detection of light stimulus GO:0009583 13 12 0,000 0,03773402 0,06031553 ! synaptogenesis GO:0007416 12 12 0,000 0,03773402 0,06026326 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,03773402 0,06021109 ! hormone transport GO:0009914 12 12 0,000 0,03773402 0,060159 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,03773402 0,060107 ! heme biosynthetic process GO:0006783 12 12 0,000 0,03773402 0,0600551 ! spermatid differentiation GO:0048515 13 12 0,000 0,03773402 0,06000328 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,03773402 0,05995156 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,03773402 0,05989992 ! neural tube closure GO:0001843 13 12 0,000 0,03773402 0,05984837 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 0,000 0,03773402 0,05979691 ! negative regulation of translation GO:0017148 12 12 0,000 0,03773402 0,05974554 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 0,000 0,03773402 0,05969425 ! posttranscriptional regulation of gene expression GO:0010608 98 98 1,000 0,0385597 0,06094814 ! blood circulation GO:0008015 99 98 1,000 0,0385597 0,06089592 GO:0003013|circulatory system process, ! response to hormone stimulus GO:0009725 102 100 1,000 0,04000451 0,06312356 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 0,000 0,04081641 0,06434957 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,04081641 0,06429457 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,04081641 0,06423967 ! phenol metabolic process GO:0018958 13 13 0,000 0,04081641 0,06418485 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! gluconeogenesis GO:0006094 13 13 0,000 0,04081641 0,06413013 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,04081641 0,06407551 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,04081641 0,06402098 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,04081641 0,06396654 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,04081641 0,06391219 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,04081641 0,06385794 ! regeneration GO:0031099 13 13 0,000 0,04081641 0,06380377 ! keratinization GO:0031424 13 13 0,000 0,04081641 0,0637497 ! post-embryonic development GO:0009791 14 13 0,000 0,04081641 0,06369572 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,04081641 0,06364183 ! patterning of blood vessels GO:0001569 13 13 0,000 0,04081641 0,06358804 ! vasculogenesis GO:0001570 13 13 0,000 0,04081641 0,06353433 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,04081641 0,06348072 ! regulation of innate immune response GO:0045088 13 13 0,000 0,04081641 0,06342719 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,04081641 0,06337376 ! response to corticosteroid stimulus GO:0031960 13 13 0,000 0,04081641 0,06332041 GO:0051384|response to glucocorticoid stimulus, ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,04081641 0,06326716 ! autophagy GO:0006914 13 13 0,000 0,04081641 0,06321399 ! actin filament bundle formation GO:0051017 13 13 0,000 0,04081641 0,06316091 ! ureteric bud development GO:0001657 13 13 0,000 0,04081641 0,06310793 ! regulation of endothelial cell migration GO:0010594 13 13 0,000 0,04081641 0,06305503 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,04081641 0,06300222 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,04081641 0,0629495 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,04081641 0,06289686 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,04081641 0,06284432 ! regulation of viral reproduction GO:0050792 13 13 0,000 0,04081641 0,06279186 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,04081641 0,06273949 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,04081641 0,06268721 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,04081641 0,06263501 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,04081641 0,0625829 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,04081641 0,06253088 ! vasodilation GO:0042311 14 13 0,000 0,04081641 0,06247894 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,04081641 0,06242709 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 0,000 0,04081641 0,06237533 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,04081641 0,06232365 GO:0006664|glycolipid metabolic process, ! positive regulation of locomotion GO:0040017 13 13 0,000 0,04081641 0,06227206 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! neural crest cell migration GO:0001755 14 13 0,000 0,04081641 0,06222055 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,04081641 0,06216913 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,04081641 0,06211779 ! immunoglobulin production GO:0002377 13 13 0,000 0,04081641 0,06206654 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,04081641 0,06201537 ! negative regulation of intracellular transport GO:0032387 13 13 0,000 0,04081641 0,06196429 ! cell-cell junction organization GO:0045216 13 13 0,000 0,04081641 0,06191329 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,04081641 0,06186238 ! response to cytokine stimulus GO:0034097 13 13 0,000 0,04081641 0,06181154 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,04081641 0,06176079 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,04081641 0,06171013 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,04081641 0,06165955 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,04081641 0,06160905 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,04081641 0,06155863 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,04081641 0,0615083 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,04081641 0,06145805 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,04081641 0,06140788 ! blastocyst development GO:0001824 13 13 0,000 0,04081641 0,06135779 ! telomere organization GO:0032200 13 13 0,000 0,04081641 0,06130778 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,04081641 0,06125786 ! regulation of amine transport GO:0051952 13 13 0,000 0,04081641 0,06120801 ! tissue homeostasis GO:0001894 13 13 0,000 0,04081641 0,06115825 GO:0048871|multicellular organismal homeostasis, ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,04081641 0,06110857 ! neuron fate commitment GO:0048663 14 14 0,000 0,04388938 0,06565594 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,04388938 0,06560269 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,04388938 0,06554953 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,04388938 0,06549645 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,04388938 0,06544346 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,04388938 0,06539056 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,04388938 0,06533774 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,04388938 0,065285 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,04388938 0,06523235 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,04388938 0,06517979 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,04388938 0,06512731 ! vesicle docking GO:0048278 14 14 0,000 0,04388938 0,06507492 ! superoxide metabolic process GO:0006801 15 14 0,000 0,04388938 0,0650226 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,04388938 0,06497038 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,04388938 0,06491823 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,04388938 0,06486617 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,04388938 0,0648142 ! hair cycle GO:0042633 14 14 0,000 0,04388938 0,06476231 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,04388938 0,0647105 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to retinoic acid GO:0032526 14 14 0,000 0,04388938 0,06465877 GO:0033189|response to vitamin A, ! multicellular organismal response to stress GO:0033555 14 14 0,000 0,04388938 0,06460712 ! lysosome organization GO:0007040 14 14 0,000 0,04388938 0,06455556 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,04388938 0,06450408 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,04388938 0,06445268 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 0,000 0,04388938 0,06440137 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 0,000 0,04388938 0,06435013 ! primary neural tube formation GO:0014020 15 14 0,000 0,04388938 0,06429898 ! peptide cross-linking GO:0018149 14 14 0,000 0,04388938 0,06424791 ! regulation of behavior GO:0050795 14 14 0,000 0,04388938 0,06419692 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,04388938 0,06414601 ! response to organic cyclic substance GO:0014070 15 14 0,000 0,04388938 0,06409518 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,04388938 0,06404443 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,04388938 0,06399377 ! formation of primary germ layer GO:0001704 14 14 0,000 0,04388938 0,06394318 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,04388938 0,06389267 ! collagen fibril organization GO:0030199 14 14 0,000 0,04388938 0,06384224 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,04388938 0,06379189 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,04388938 0,06374162 ! positive regulation of inflammatory response GO:0050729 14 14 0,000 0,04388938 0,06369143 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,04388938 0,06364132 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,04388938 0,06359129 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,04388938 0,06354133 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,04388938 0,06349146 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,04388938 0,06344166 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,04388938 0,06339194 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,04695294 0,06776372 ! positive regulation of ossification GO:0045778 15 15 0,000 0,04695294 0,0677107 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,04695294 0,06765776 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,04695294 0,0676049 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,04695294 0,06755212 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,04695294 0,06749943 ! response to vitamin GO:0033273 15 15 0,000 0,04695294 0,06744682 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,04695294 0,06739429 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,04695294 0,06734184 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,04695294 0,06728948 ! ovarian follicle development GO:0001541 15 15 0,000 0,04695294 0,06723719 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,04695294 0,06718499 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,04695294 0,06713287 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,04695294 0,06708083 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,04695294 0,06702887 ! heme metabolic process GO:0042168 15 15 0,000 0,04695294 0,06697699 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,04695294 0,06692519 ! chromosome condensation GO:0030261 15 15 0,000 0,04695294 0,06687347 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,04695294 0,06682183 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,04695294 0,06677027 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,04695294 0,06671879 GO:0030500|regulation of bone mineralization, ! regulation of production of molecular mediator of immune response GO:0002700 15 15 0,000 0,04695294 0,06666739 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,04695294 0,06661607 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,04695294 0,06656482 ! phospholipid transport GO:0015914 15 15 0,000 0,04695294 0,06651366 ! leukocyte homeostasis GO:0001776 15 15 0,000 0,04695294 0,06646257 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,04695294 0,06641156 ! glutathione metabolic process GO:0006749 16 15 0,000 0,04695294 0,06636064 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,04695294 0,06630978 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 0,000 0,04695294 0,06625901 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,04695294 0,06620832 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,04695294 0,0661577 ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,04695294 0,06610716 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,04695294 0,06605669 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,05000713 0,07029988 ! alkaloid metabolic process GO:0009820 16 16 0,000 0,05000713 0,0702463 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,05000713 0,0701928 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,05000713 0,07013938 ! learning GO:0007612 16 16 0,000 0,05000713 0,07008604 ! circadian rhythm GO:0007623 16 16 0,000 0,05000713 0,07003279 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,05000713 0,06997961 ! positive regulation of mitosis GO:0045840 16 16 0,000 0,05000713 0,06992651 GO:0051785|positive regulation of nuclear division, ! vacuole organization GO:0007033 16 16 0,000 0,05000713 0,0698735 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,05000713 0,06982057 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,05000713 0,06976771 ! vesicle targeting GO:0006903 17 16 0,000 0,05000713 0,06971494 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,05000713 0,06966224 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,05000713 0,06960963 ! iron ion homeostasis GO:0055072 16 16 0,000 0,05000713 0,06955709 ! positive regulation of cell development GO:0010720 16 16 0,000 0,05000713 0,06950464 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,05000713 0,06945226 ! lymphocyte proliferation GO:0046651 16 16 0,000 0,05000713 0,06939996 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,05000713 0,06934774 ! cell fate specification GO:0001708 16 16 0,000 0,05000713 0,0692956 ! pentose metabolic process GO:0019321 16 16 0,000 0,05000713 0,06924354 ! fatty acid transport GO:0015908 16 16 0,000 0,05000713 0,06919155 ! positive regulation of MAPKKK cascade GO:0043410 17 16 0,000 0,05000713 0,06913964 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 0,000 0,05000713 0,06908782 ! cofactor catabolic process GO:0051187 16 16 0,000 0,05000713 0,06903606 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,05000713 0,06898439 ! polyol metabolic process GO:0019751 16 16 0,000 0,05000713 0,06893279 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,05000713 0,06888128 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,05000713 0,06882983 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,05000713 0,06877847 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,05000713 0,06872718 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,05000713 0,06867597 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,05000713 0,06862483 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,05000713 0,06857377 ! regulation of coagulation GO:0050818 17 16 0,000 0,05000713 0,06852279 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 0,000 0,05305198 0,07264101 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 0,000 0,05305198 0,07258708 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,05305198 0,07253324 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,05305198 0,07247947 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,05305198 0,07242578 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,05305198 0,07237217 ! leukocyte adhesion GO:0007159 17 17 0,000 0,05305198 0,07231864 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,05305198 0,07226519 ! sensory perception of smell GO:0007608 17 17 0,000 0,05305198 0,07221182 ! glucose transport GO:0015758 17 17 0,000 0,05305198 0,07215853 ! cell junction assembly GO:0034329 18 17 0,000 0,05305198 0,07210531 ! tissue remodeling GO:0048771 17 17 0,000 0,05305198 0,07205218 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,05305198 0,07199912 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,05305198 0,07194614 ! development of primary male sexual characteristics GO:0046546 17 17 0,000 0,05305198 0,07189324 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,05305198 0,07184041 ! neural crest cell development GO:0014032 19 17 0,000 0,05305198 0,07178767 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 18 17 0,000 0,05305198 0,071735 ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,05305198 0,07168241 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,05305198 0,07162989 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,05305198 0,07157745 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,05305198 0,07152509 ! pigmentation GO:0043473 17 17 0,000 0,05305198 0,07147281 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,05305198 0,0714206 ! adult locomotory behavior GO:0008344 17 17 0,000 0,05305198 0,07136847 ! embryonic organ development GO:0048568 17 17 0,000 0,05305198 0,07131641 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,05305198 0,07126443 ! liver development GO:0001889 17 17 0,000 0,05305198 0,07121253 ! gene silencing GO:0016458 17 17 0,000 0,05305198 0,0711607 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,05608751 0,07517766 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,05608751 0,07512303 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,05608751 0,07506847 ! meiosis I GO:0007127 18 18 0,000 0,05608751 0,075014 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,05608751 0,0749596 ! membrane docking GO:0022406 18 18 0,000 0,05608751 0,07490528 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,05608751 0,07485104 ! mononuclear cell proliferation GO:0032943 18 18 0,000 0,05608751 0,07479688 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 0,000 0,05608751 0,0747428 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,05608751 0,07468879 ! hexose transport GO:0008645 18 18 0,000 0,05608751 0,07463487 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 0,000 0,05608751 0,07458102 GO:0055092|sterol homeostasis, ! striated muscle contraction GO:0006941 18 18 0,000 0,05608751 0,07452724 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,05608751 0,07447355 GO:0006639|acylglycerol metabolic process, ! ceramide metabolic process GO:0006672 18 18 0,000 0,05608751 0,07441993 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,05608751 0,07436639 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,05608751 0,07431293 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,05608751 0,07425955 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,05608751 0,07420624 ! BMP signaling pathway GO:0030509 18 18 0,000 0,05608751 0,074153 ! regulation of microtubule-based process GO:0032886 18 18 0,000 0,05608751 0,07409985 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,05608751 0,07404677 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,05911376 0,07798615 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,05911376 0,07793037 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 19 19 0,000 0,05911376 0,07787466 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,05911376 0,07781904 ! feeding behavior GO:0007631 19 19 0,000 0,05911376 0,07776349 ! regulation of endothelial cell proliferation GO:0001936 19 19 0,000 0,05911376 0,07770803 ! peroxisome organization GO:0007031 19 19 0,000 0,05911376 0,07765264 ! positive regulation of T cell proliferation GO:0042102 19 19 0,000 0,05911376 0,07759733 ! regulation of striated muscle tissue development GO:0016202 20 19 0,000 0,05911376 0,0775421 ! multicellular organismal metabolic process GO:0044236 19 19 0,000 0,05911376 0,07748695 ! metanephros development GO:0001656 19 19 0,000 0,05911376 0,07743188 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,05911376 0,07737688 ! cellular response to oxidative stress GO:0034599 19 19 0,000 0,05911376 0,07732197 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,05911376 0,07726713 ! positive regulation of T cell differentiation GO:0045582 19 19 0,000 0,05911376 0,07721237 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,05911376 0,07715769 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,05911376 0,07710308 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,05911376 0,07704855 ! eye morphogenesis GO:0048592 19 19 0,000 0,05911376 0,0769941 ! regulation of cell shape GO:0008360 21 19 0,000 0,05911376 0,07693973 ! placenta development GO:0001890 19 19 0,000 0,05911376 0,07688543 ! response to heat GO:0009408 19 19 0,000 0,05911376 0,07683121 ! vesicle localization GO:0051648 20 19 0,000 0,05911376 0,07677706 ! regulation of muscle development GO:0048634 21 20 0,000 0,06213074 0,08063869 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,06213074 0,08058195 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,06213074 0,08052528 ! organic ether metabolic process GO:0018904 20 20 0,000 0,06213074 0,08046869 GO:0006662|glycerol ether metabolic process, ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,06213074 0,08041218 ! neural tube development GO:0021915 21 20 0,000 0,06213074 0,08035575 ! nucleus organization GO:0006997 20 20 0,000 0,06213074 0,0802994 ! phagocytosis GO:0006909 21 20 0,000 0,06213074 0,08024313 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,06213074 0,08018694 ! protein targeting to membrane GO:0006612 22 20 0,000 0,06213074 0,08013082 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,06213074 0,08007479 ! chromatin remodeling GO:0006338 20 20 0,000 0,06213074 0,08001883 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,06213074 0,07996295 ! lipid oxidation GO:0034440 20 20 0,000 0,06213074 0,07990715 GO:0019395|fatty acid oxidation, ! female gamete generation GO:0007292 20 20 0,000 0,06213074 0,07985143 ! negative regulation of neuron apoptosis GO:0043524 21 20 0,000 0,06213074 0,07979578 ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,06213074 0,07974021 ! RNA modification GO:0009451 20 20 0,000 0,06213074 0,07968472 ! single fertilization GO:0007338 21 20 0,000 0,06213074 0,07962931 ! regulation of B cell activation GO:0050864 20 20 0,000 0,06213074 0,07957397 ! mitotic sister chromatid segregation GO:0000070 21 21 0,000 0,06513848 0,08336821 ! mRNA catabolic process GO:0006402 21 21 0,000 0,06513848 0,08331035 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,06513848 0,08325258 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,06513848 0,08319488 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,06513848 0,08313727 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,06513848 0,08307974 ! ear morphogenesis GO:0042471 21 21 0,000 0,06513848 0,08302228 ! organic anion transport GO:0015711 21 21 0,000 0,06513848 0,08296491 ! cholesterol transport GO:0030301 21 21 0,000 0,06513848 0,08290761 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,06513848 0,08285039 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,06513848 0,08279325 GO:0032313|regulation of Rab GTPase activity, ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,06513848 0,08273619 ! regulation of multicellular organism growth GO:0040014 21 21 0,000 0,06513848 0,08267921 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,06513848 0,08262231 ! regulation of proteolysis GO:0030162 21 21 0,000 0,06513848 0,08256549 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 0,000 0,06513848 0,08250874 ! RNA export from nucleus GO:0006405 22 22 0,000 0,06813702 0,08624761 ! sister chromatid segregation GO:0000819 22 22 0,000 0,06813702 0,08618841 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,06813702 0,0861293 ! regulation of ion transport GO:0043269 22 22 0,000 0,06813702 0,08607027 ! odontogenesis GO:0042476 22 22 0,000 0,06813702 0,08601131 ! cell junction organization GO:0034330 23 22 0,000 0,06813702 0,08595244 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 0,000 0,06813702 0,08589365 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! hormone-mediated signaling GO:0009755 22 22 0,000 0,06813702 0,08583494 ! ovulation cycle process GO:0022602 22 22 0,000 0,06813702 0,08577631 ! spindle organization GO:0007051 22 22 0,000 0,06813702 0,08571776 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,06813702 0,08565929 ! cell chemotaxis GO:0060326 23 22 0,000 0,06813702 0,0856009 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,06813702 0,08554259 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,06813702 0,08548436 ! male sex differentiation GO:0046661 22 22 0,000 0,06813702 0,0854262 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,06813702 0,08536813 ! biopolymer methylation GO:0043414 22 22 0,000 0,06813702 0,08531014 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 0,000 0,06813702 0,08525222 ! detection of external stimulus GO:0009581 23 22 0,000 0,06813702 0,08519438 ! neuron migration GO:0001764 22 22 0,000 0,06813702 0,08513662 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,06813702 0,08507894 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,06813702 0,08502134 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 0,000 0,06813702 0,08496382 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,06813702 0,08490637 ! aerobic respiration GO:0009060 22 22 0,000 0,06813702 0,084849 ! cytokine production GO:0001816 22 22 0,000 0,06813702 0,08479171 ! cytokinesis GO:0000910 23 22 0,000 0,06813702 0,08473449 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,06813702 0,08467736 ! response to hydrogen peroxide GO:0042542 24 23 0,000 0,07112637 0,08833282 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,07112637 0,08827333 ! viral infectious cycle GO:0019058 23 23 0,000 0,07112637 0,08821393 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,07112637 0,08815461 ! response to estrogen stimulus GO:0043627 23 23 0,000 0,07112637 0,08809536 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,07112637 0,0880362 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,07112637 0,08797711 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,07112637 0,08791811 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,07112637 0,08785918 ! endocrine system development GO:0035270 23 23 0,000 0,07112637 0,08780033 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,07112637 0,08774156 ! female gonad development GO:0008585 23 23 0,000 0,07112637 0,08768287 ! lipid homeostasis GO:0055088 23 23 0,000 0,07112637 0,08762426 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,07112637 0,08756573 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,07112637 0,08750727 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,07410657 0,09111301 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,07410657 0,09105227 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,07410657 0,09099161 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,07410657 0,09093103 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,07410657 0,09087053 ! ovulation cycle GO:0042698 24 24 0,000 0,07410657 0,09081011 ! fertilization GO:0009566 25 24 0,000 0,07410657 0,09074977 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,07410657 0,09068951 ! epithelial tube morphogenesis GO:0060562 25 24 0,000 0,07410657 0,09062933 ! glucan metabolic process GO:0044042 25 24 0,000 0,07410657 0,09056923 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,07707764 0,0941379 ! negative regulation of secretion GO:0051048 26 25 0,000 0,07707764 0,09407555 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,07707764 0,09401329 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,07707764 0,09395111 ! cellular component disassembly GO:0022411 26 25 0,000 0,07707764 0,09388902 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,07707764 0,093827 ! development of primary female sexual characteristics GO:0046545 25 25 0,000 0,07707764 0,09376507 GO:0046660|female sex differentiation, ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,07707764 0,09370322 ! excretion GO:0007588 25 25 0,000 0,07707764 0,09364145 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,07707764 0,09357977 ! gastrulation GO:0007369 25 25 0,000 0,07707764 0,09351816 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,07707764 0,09345663 ! regulation of endocytosis GO:0030100 25 25 0,000 0,07707764 0,09339519 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,07707764 0,09333383 ! positive regulation of cytokine production GO:0001819 25 25 0,000 0,07707764 0,09327254 ! positive regulation of defense response GO:0031349 26 26 0,000 0,08003961 0,0967933 ! glycolysis GO:0006096 26 26 0,000 0,08003961 0,09672983 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,08003961 0,09666644 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,08003961 0,09660314 ! negative regulation of cell migration GO:0030336 26 26 0,000 0,08003961 0,09653992 ! cellular defense response GO:0006968 26 26 0,000 0,08003961 0,09647678 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,08003961 0,09641372 ! regulation of protein secretion GO:0050708 26 26 0,000 0,08003961 0,09635075 ! germ cell development GO:0007281 27 26 0,000 0,08003961 0,09628785 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,08003961 0,09622504 GO:0035150|regulation of tube size, ! pigment metabolic process GO:0042440 26 26 0,000 0,08003961 0,09616232 ! chloride transport GO:0006821 27 27 0,000 0,0829925 0,09964506 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,0829925 0,09958019 ! energy reserve metabolic process GO:0006112 28 27 0,000 0,0829925 0,0995154 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,0829925 0,0994507 ! peptide metabolic process GO:0006518 29 27 0,000 0,0829925 0,09938608 ! inner ear development GO:0048839 27 27 0,000 0,0829925 0,09932154 ! defense response to bacterium GO:0042742 27 27 0,000 0,0829925 0,09925709 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,0829925 0,09919272 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,0829925 0,09912843 ! cell growth GO:0016049 27 27 0,000 0,0829925 0,09906423 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,08593634 0,10251177 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,08593634 0,10244546 GO:0007254|JNK cascade, ! neuromuscular process GO:0050905 28 28 0,000 0,08593634 0,10237924 ! carbohydrate transport GO:0008643 28 28 0,000 0,08593634 0,1023131 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,08593634 0,10224705 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,08593634 0,10218108 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,08593634 0,1021152 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,08593634 0,10204941 ! developmental growth GO:0048589 28 28 0,000 0,08593634 0,1019837 ! cartilage development GO:0051216 29 28 0,000 0,08593634 0,10191807 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,08887116 0,1053309 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,08887116 0,10526321 ! leukocyte migration GO:0050900 30 29 0,000 0,08887116 0,1051956 ! branching morphogenesis of a tube GO:0048754 29 29 0,000 0,08887116 0,10512808 ! antigen processing and presentation GO:0019882 29 29 0,000 0,08887116 0,10506065 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,08887116 0,10499331 ! tRNA processing GO:0008033 29 29 0,000 0,08887116 0,10492605 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,08887116 0,10485887 ! adult behavior GO:0030534 30 29 0,000 0,08887116 0,10479178 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,08887116 0,10472478 ! transition metal ion transport GO:0000041 31 30 0,000 0,09179699 0,10810342 ! RNA catabolic process GO:0006401 30 30 0,000 0,09179699 0,10803439 ! response to reactive oxygen species GO:0000302 31 30 0,000 0,09179699 0,10796545 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,09179699 0,10789659 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,09179699 0,10782782 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,09179699 0,10775914 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,09179699 0,10769055 ! positive regulation of response to external stimulus GO:0032103 30 30 0,000 0,09179699 0,10762204 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,09179699 0,10755363 ! response to temperature stimulus GO:0009266 30 30 0,000 0,09179699 0,10748529 ! vascular process in circulatory system GO:0003018 31 30 0,000 0,09179699 0,10741705 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,09179699 0,10734889 GO:0019724|B cell mediated immunity, ! regulation of inflammatory response GO:0050727 30 30 0,000 0,09179699 0,10728082 ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,09179699 0,10721284 ! vesicle organization GO:0016050 30 30 0,000 0,09179699 0,10714494 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,09179699 0,10707712 ! establishment of organelle localization GO:0051656 31 30 0,000 0,09179699 0,1070094 ! regulation of translational initiation GO:0006446 31 31 0,000 0,09471385 0,11033984 ! membrane fusion GO:0006944 31 31 0,000 0,09471385 0,11027013 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,09471385 0,11020052 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,09471385 0,11013099 ! ion transmembrane transport GO:0034220 31 31 0,000 0,09471385 0,11006155 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,09471385 0,1099922 ! digestion GO:0007586 31 31 0,000 0,09471385 0,10992293 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,09471385 0,10985376 ! regulation of heart contraction GO:0008016 31 31 0,000 0,09471385 0,10978467 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,09471385 0,10971566 ! camera-type eye development GO:0043010 31 31 0,000 0,09471385 0,10964675 ! extracellular matrix organization GO:0030198 31 31 0,000 0,09471385 0,10957792 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,09471385 0,10950917 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,09471385 0,10944051 ! negative regulation of cell motion GO:0051271 31 31 0,000 0,09471385 0,10937194 ! cell redox homeostasis GO:0045454 32 32 0,000 0,09762176 0,1126593 ! glucose catabolic process GO:0006007 32 32 0,000 0,09762176 0,1125888 ! lipid modification GO:0030258 32 32 0,000 0,09762176 0,11251839 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,09762176 0,11244806 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,09762176 0,11237783 ! cell maturation GO:0048469 32 32 0,000 0,09762176 0,11230768 ! morphogenesis of a branching structure GO:0001763 32 32 0,000 0,09762176 0,11223762 ! nuclear export GO:0051168 32 32 0,000 0,09762176 0,11216765 ! kidney development GO:0001822 32 32 0,000 0,09762176 0,11209776 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,10052076 0,11535476 ! amino acid transport GO:0006865 33 33 0,000 0,10052076 0,11528298 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,10052076 0,11521129 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,10052076 0,11513968 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,10052076 0,11506817 ! regulation of neuron differentiation GO:0045664 34 33 0,000 0,10052076 0,11499674 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,10052076 0,1149254 ! regulation of actin filament length GO:0030832 34 34 0,000 0,10341086 0,11815636 ! response to metal ion GO:0010038 34 34 0,000 0,10341086 0,11808316 ! ear development GO:0043583 34 34 0,000 0,10341086 0,11801004 ! muscle cell differentiation GO:0042692 35 34 0,000 0,10341086 0,11793701 ! cellular polysaccharide metabolic process GO:0044264 35 34 0,000 0,10341086 0,11786408 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,10341086 0,11779123 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,10341086 0,11771848 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,10341086 0,11764581 ! secondary metabolic process GO:0019748 34 34 0,000 0,10341086 0,11757324 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,10341086 0,11750075 ! detection of stimulus GO:0051606 36 34 0,000 0,10341086 0,11742835 ! acute inflammatory response GO:0002526 35 35 0,000 0,1062921 0,12062582 ! regulation of cellular component size GO:0032535 35 35 0,000 0,1062921 0,12055159 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,1062921 0,12047745 ! mesoderm development GO:0007498 35 35 0,000 0,1062921 0,1204034 ! multicellular organism reproduction GO:0032504 36 35 0,000 0,1062921 0,12032945 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 0,000 0,1062921 0,12025558 ! inorganic anion transport GO:0015698 35 35 0,000 0,1062921 0,1201818 ! response to steroid hormone stimulus GO:0048545 35 35 0,000 0,1062921 0,12010812 ! regulation of immune effector process GO:0002697 35 35 0,000 0,1062921 0,12003452 ! hydrogen transport GO:0006818 36 36 0,000 0,1091645 0,1232028 GO:0015992|proton transport, ! response to inorganic substance GO:0010035 36 36 0,000 0,1091645 0,1231274 ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,1091645 0,12305209 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 0,000 0,1091645 0,12297688 ! regulation of mitosis GO:0007088 37 36 0,000 0,1091645 0,12290175 GO:0051783|regulation of nuclear division, ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,1091645 0,12282672 GO:0035113|embryonic appendage morphogenesis, ! female pregnancy GO:0007565 37 36 0,000 0,1091645 0,12275178 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,1091645 0,12267693 ! positive regulation of organelle organization GO:0010638 36 36 0,000 0,1091645 0,12260218 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,1091645 0,12252751 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,1091645 0,12245293 ! gonad development GO:0008406 36 36 0,000 0,1091645 0,12237845 ! activation of immune response GO:0002253 36 36 0,000 0,1091645 0,12230405 ! coagulation GO:0050817 39 36 0,000 0,1091645 0,12222975 GO:0007596|blood coagulation, ! meiosis GO:0007126 37 37 0,000 0,11202808 0,1253599 GO:0051327|M phase of meiotic cell cycle, ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,11202808 0,12528383 ! eye development GO:0001654 37 37 0,000 0,11202808 0,12520786 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,11202808 0,12513197 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,11202808 0,12505618 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,11202808 0,12498048 ! adaptive immune response GO:0002250 37 37 0,000 0,11202808 0,12490487 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of secretion GO:0051047 39 38 0,000 0,11488288 0,12801037 ! neurotransmitter transport GO:0006836 40 38 0,000 0,11488288 0,12793302 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,11488288 0,12785577 ! exocytosis GO:0006887 40 38 0,000 0,11488288 0,12777861 ! urogenital system development GO:0001655 38 38 0,000 0,11488288 0,12770154 ! hexose catabolic process GO:0019320 38 38 0,000 0,11488288 0,12762456 ! RNA elongation GO:0006354 38 38 0,000 0,11488288 0,12754768 ! meiotic cell cycle GO:0051321 38 38 0,000 0,11488288 0,12747089 ! regulation of neurological system process GO:0031644 38 38 0,000 0,11488288 0,12739419 ! hemostasis GO:0007599 42 39 0,000 0,11772892 0,13047167 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,11772892 0,13039327 ! response to unfolded protein GO:0006986 39 39 0,000 0,11772892 0,13031495 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,11772892 0,13023673 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,11772892 0,13015861 ! cytokine-mediated signaling pathway GO:0019221 39 39 0,000 0,11772892 0,13008057 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,11772892 0,13000263 ! regulation of MAPKKK cascade GO:0043408 41 39 0,000 0,11772892 0,12992479 ! positive regulation of T cell activation GO:0050870 39 39 0,000 0,11772892 0,12984703 ! developmental maturation GO:0021700 39 39 0,000 0,11772892 0,12976937 ! limb development GO:0060173 39 39 0,000 0,11772892 0,12969181 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! DNA catabolic process GO:0006308 41 40 0,000 0,12056622 0,13273807 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,12056622 0,13265883 ! organelle localization GO:0051640 41 40 0,000 0,12056622 0,13257968 ! amine catabolic process GO:0009310 42 41 0,000 0,1233948 0,1356092 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,1233948 0,13552838 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,1233948 0,13544766 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,1233948 0,13536704 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,1233948 0,13528651 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,1233948 0,13520608 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,12621471 0,13821373 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,12621471 0,13813165 ! development of primary sexual characteristics GO:0045137 42 42 0,000 0,12621471 0,13804968 ! protein ubiquitination GO:0016567 43 42 0,000 0,12621471 0,1379678 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,12621471 0,13788601 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! response to protein stimulus GO:0051789 42 42 0,000 0,12621471 0,13780433 ! forebrain development GO:0030900 43 42 0,000 0,12621471 0,13772274 ! one-carbon metabolic process GO:0006730 42 42 0,000 0,12621471 0,13764125 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 0,000 0,12621471 0,13755985 ! reproductive structure development GO:0048608 43 43 0,000 0,12902595 0,14054068 ! alcohol catabolic process GO:0046164 43 43 0,000 0,12902595 0,14045766 ! homeostasis of number of cells GO:0048872 44 43 0,000 0,12902595 0,14037475 ! humoral immune response GO:0006959 44 44 0,000 0,13182856 0,14333925 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 0,000 0,13182856 0,14325474 ! mRNA transport GO:0051028 44 44 0,000 0,13182856 0,14317032 ! negative regulation of organelle organization GO:0010639 45 44 0,000 0,13182856 0,143086 ! vitamin metabolic process GO:0006766 44 44 0,000 0,13182856 0,14300178 ! positive regulation of lymphocyte activation GO:0051251 44 44 0,000 0,13182856 0,14291767 ! amine biosynthetic process GO:0009309 46 45 0,000 0,13462256 0,14586089 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,13462256 0,14577519 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 0,000 0,13462256 0,14568959 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,13462256 0,14560409 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,13740797 0,14852955 ! tube morphogenesis GO:0035239 47 46 0,000 0,13740797 0,14844249 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 0,000 0,13740797 0,14835553 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,13740797 0,14826867 ! positive regulation of ligase activity GO:0051351 47 46 0,000 0,13740797 0,14818191 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,14018482 0,15108809 ! regulation of blood pressure GO:0008217 48 47 0,000 0,14018482 0,15099978 ! sex differentiation GO:0007548 47 47 0,000 0,14018482 0,15091158 ! amine transport GO:0015837 47 47 0,000 0,14018482 0,15082349 ! rhythmic process GO:0048511 47 47 0,000 0,14018482 0,15073549 ! calcium ion transport GO:0006816 48 48 0,000 0,14295314 0,15362253 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 0,000 0,14295314 0,15353301 ! regulation of cell cycle process GO:0010564 50 48 0,000 0,14295314 0,15344359 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,14295314 0,15335428 ! DNA recombination GO:0006310 48 48 0,000 0,14295314 0,15326506 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,14571296 0,15613313 ! divalent metal ion transport GO:0070838 49 49 0,000 0,14571296 0,1560424 ! response to nutrient GO:0007584 49 49 0,000 0,14571296 0,15595179 ! response to bacterium GO:0009617 50 49 0,000 0,14571296 0,15586128 ! regulation of ligase activity GO:0051340 50 49 0,000 0,14571296 0,15577087 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,14571296 0,15568057 ! positive regulation of cell activation GO:0050867 49 49 0,000 0,14571296 0,15559037 GO:0002696|positive regulation of leukocyte activation, ! regulation of defense response GO:0031347 50 50 0,000 0,14846428 0,15843641 ! chromatin assembly GO:0031497 50 50 0,000 0,14846428 0,15834472 GO:0006334|nucleosome assembly, ! RNA transport GO:0050658 50 50 0,000 0,14846428 0,15825314 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,14846428 0,15816166 ! transcription initiation GO:0006352 50 50 0,000 0,14846428 0,15807029 ! anatomical structure homeostasis GO:0060249 51 50 0,000 0,14846428 0,15797903 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,15120715 0,16080483 ! protein modification by small protein conjugation GO:0032446 52 51 0,000 0,15120715 0,1607121 ! positive regulation of immune response GO:0050778 51 51 0,000 0,15120715 0,16061947 ! rRNA metabolic process GO:0016072 51 51 0,000 0,15120715 0,16052695 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,15120715 0,16043453 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,15120715 0,16034222 ! RNA localization GO:0006403 52 52 0,000 0,15394158 0,16314798 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,15394158 0,16305422 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,15394158 0,16296056 ! regulation of body fluid levels GO:0050878 55 52 0,000 0,15394158 0,16286701 ! sodium ion transport GO:0006814 53 53 0,000 0,15666761 0,165656 ! tRNA metabolic process GO:0006399 53 53 0,000 0,15666761 0,16556101 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,15666761 0,16546613 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,15666761 0,16537136 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,15666761 0,1652767 ! protein amino acid dephosphorylation GO:0006470 55 54 0,000 0,15938524 0,16804749 ! response to virus GO:0009615 54 54 0,000 0,15938524 0,1679514 ! hormone metabolic process GO:0042445 55 54 0,000 0,15938524 0,16785543 ! sulfur metabolic process GO:0006790 55 54 0,000 0,15938524 0,16775957 ! negative regulation of multicellular organismal process GO:0051241 55 54 0,000 0,15938524 0,16766382 ! nucleosome organization GO:0034728 55 55 0,000 0,16209452 0,17041654 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,16209452 0,17031939 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! protein modification by small protein conjugation or removal GO:0070647 56 55 0,000 0,16209452 0,17022234 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,16479546 0,17296016 ! ATP metabolic process GO:0046034 57 57 0,000 0,16748809 0,17568614 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,16748809 0,17558621 ! innate immune response GO:0045087 58 58 0,000 0,17017243 0,17829892 ! dephosphorylation GO:0016311 60 59 0,000 0,17284851 0,18099989 ! carboxylic acid transport GO:0046942 59 59 0,000 0,17284851 0,18089711 GO:0015849|organic acid transport, ! sterol metabolic process GO:0016125 59 59 0,000 0,17284851 0,18079444 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,17284851 0,18069189 ! immune effector process GO:0002252 59 59 0,000 0,17284851 0,18058946 ! potassium ion transport GO:0006813 60 60 0,000 0,17551635 0,18327288 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 0,000 0,17551635 0,1831691 ! protein polymerization GO:0051258 65 60 0,000 0,17551635 0,18306544 ! cellular respiration GO:0045333 62 61 0,000 0,17817598 0,18573435 ! proteasomal protein catabolic process GO:0010498 62 61 0,000 0,17817598 0,18562935 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,17817598 0,18552448 GO:0016054|organic acid catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,17817598 0,18541972 ! lipid transport GO:0006869 62 62 0,000 0,18082741 0,18807275 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,18082741 0,18796668 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,18082741 0,18786072 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,18082741 0,18775488 ! regulation of secretion GO:0051046 65 63 0,000 0,18347068 0,19039215 ! negative regulation of cellular component organization GO:0051129 65 63 0,000 0,18347068 0,19028501 ! glucose metabolic process GO:0006006 63 63 0,000 0,18347068 0,19017798 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,18347068 0,19007108 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,18347068 0,1899643 ! glycerolipid metabolic process GO:0046486 65 64 0,000 0,1861058 0,1925845 ! regulation of response to external stimulus GO:0032101 65 64 0,000 0,1861058 0,19247643 ! regulation of cytoskeleton organization GO:0051493 66 64 0,000 0,1861058 0,19236848 ! positive regulation of protein metabolic process GO:0051247 64 64 0,000 0,1861058 0,19226065 ! anion transport GO:0006820 65 65 0,000 0,18873281 0,1948653 ! positive regulation of cellular component organization GO:0051130 65 65 0,000 0,18873281 0,19475619 ! regulation of hormone levels GO:0010817 66 65 0,000 0,18873281 0,19464721 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,19135172 0,19723782 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,19135172 0,19712757 ! DNA packaging GO:0006323 66 66 0,000 0,19135172 0,19701744 ! polysaccharide metabolic process GO:0005976 69 66 0,000 0,19135172 0,19690744 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,19396256 0,1994827 ! muscle contraction GO:0006936 67 67 0,000 0,19396256 0,19937144 ! Ras protein signal transduction GO:0007265 69 67 0,000 0,19396256 0,19926031 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,19656535 0,20182169 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,19656535 0,20170932 ! regulation of translation GO:0006417 69 69 0,000 0,19916012 0,20425826 ! sensory perception of sound GO:0007605 71 69 0,000 0,19916012 0,20414466 GO:0050954|sensory perception of mechanical stimulus, ! growth GO:0040007 70 70 0,000 0,20174689 0,20668122 ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,20174689 0,2065664 GO:0016053|organic acid biosynthetic process, ! translational elongation GO:0006414 71 71 0,000 0,20432568 0,20909063 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,20432568 0,2089746 ! ribosome biogenesis GO:0042254 71 71 0,000 0,20432568 0,20885869 ! negative regulation of signal transduction GO:0009968 71 71 0,000 0,20432568 0,20874292 ! secretion by cell GO:0032940 75 72 0,000 0,20689652 0,21125223 ! muscle system process GO:0003012 72 72 0,000 0,20689652 0,21113526 ! sensory organ development GO:0007423 72 72 0,000 0,20689652 0,21101842 ! regulation of cytokine production GO:0001817 72 72 0,000 0,20689652 0,2109017 ! electron transport chain GO:0022900 75 74 0,000 0,21201442 0,21599922 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,21201442 0,21587988 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,21456154 0,2183528 ! response to oxidative stress GO:0006979 76 75 0,000 0,21456154 0,2182323 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,21456154 0,21811193 ! negative regulation of cell communication GO:0010648 76 76 0,000 0,2171008 0,22057154 ! positive regulation of multicellular organismal process GO:0051240 76 76 0,000 0,2171008 0,22045001 ! microtubule-based movement GO:0007018 82 78 0,000 0,22215583 0,2254588 ! regulation of immune response GO:0050776 78 78 0,000 0,22215583 0,22533472 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,22717969 0,23030372 ! lipid catabolic process GO:0016042 82 81 0,000 0,22967999 0,2327104 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,23465744 0,2376229 ! ncRNA processing GO:0034470 83 83 0,000 0,23465744 0,23749241 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,23713465 0,23986781 ! nitrogen compound biosynthetic process GO:0044271 86 85 0,000 0,23960419 0,24223287 ! positive regulation of cell differentiation GO:0045597 87 85 0,000 0,23960419 0,24210007 ! positive regulation of response to stimulus GO:0048584 86 85 0,000 0,23960419 0,24196741 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,24206611 0,24431973 GO:0006644|phospholipid metabolic process, ! hexose metabolic process GO:0019318 87 86 0,000 0,24206611 0,24418601 ! male gamete generation GO:0048232 90 88 0,000 0,24696713 0,24899366 GO:0007283|spermatogenesis, ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,24696713 0,24885753 ! chemotaxis GO:0006935 90 89 0,000 0,24940628 0,25117802 GO:0042330|taxis, ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,25183789 0,25348838 ! visual perception GO:0007601 93 92 0,000 0,25667857 0,25821976 GO:0050953|sensory perception of light stimulus, ! fatty acid metabolic process GO:0006631 93 92 0,000 0,25667857 0,25807889 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 0,000 0,25667857 0,25793817 ! positive regulation of immune system process GO:0002684 92 92 0,000 0,25667857 0,25779761 ! regulation of response to stress GO:0080134 97 94 0,000 0,26148935 0,26248631 ! epidermis development GO:0008544 94 94 0,000 0,26148935 0,26234342 ! cofactor metabolic process GO:0051186 95 94 0,000 0,26148935 0,26220069 ! endocytosis GO:0006897 99 98 0,000 0,27102189 0,27161138 GO:0010324|membrane invagination, ! regulation of system process GO:0044057 98 98 0,000 0,27102189 0,27146377 ! anti-apoptosis GO:0006916 100 99 0,000 0,2733866 0,2736836 ! ectoderm development GO:0007398 99 99 0,000 0,2733866 0,27353502 ! response to other organism GO:0051707 101 100 0,000 0,275744 0,275744