pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6502-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of protein export from nucleus GO:0046825 6 6 4,000 4,943E-12 1,137E-08 ! regulation of intracellular protein transport GO:0033157 59 35 6,000 6,724E-11 7,733E-08 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 6,000 2,64E-10 2,024E-07 ! regulation of intracellular transport GO:0032386 78 49 6,000 8,224E-10 4,729E-07 ! negative regulation of peptide secretion GO:0002792 6 5 3,000 1,108E-09 5,096E-07 GO:0046676|negative regulation of insulin secretion, ! organ growth GO:0035265 11 7 3,000 7,708E-09 2,955E-06 ! regulation of growth hormone secretion GO:0060123 11 7 3,000 7,708E-09 2,533E-06 ! negative regulation of transport GO:0051051 116 73 6,000 1,448E-08 4,162E-06 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 1,537E-08 3,928E-06 ! regulation of protein transport GO:0051223 114 76 6,000 1,924E-08 4,426E-06 GO:0070201|regulation of establishment of protein localization, ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 4,225E-08 8,834E-06 ! regulation of protein localization GO:0032880 132 85 6,000 4,225E-08 8,098E-06 ! DNA damage response, signal transduction GO:0042770 96 56 5,000 8,417E-08 1,489E-05 ! DNA damage checkpoint GO:0000077 53 31 4,000 1,297E-07 2,131E-05 ! carbohydrate homeostasis GO:0033500 39 33 4,000 1,801E-07 2,761E-05 GO:0042593|glucose homeostasis, ! DNA integrity checkpoint GO:0031570 57 34 4,000 2,105E-07 3,025E-05 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 2,935E-07 3,971E-05 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 4,543E-07 5,805E-05 ! positive regulation of hormone secretion GO:0046887 24 17 3,000 5,088E-07 6,159E-05 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 5,852E-07 6,729E-05 ! response to UV GO:0009411 75 46 4,000 9,995E-07 1,095E-04 ! male meiosis GO:0007140 7 6 2,000 1,167E-06 1,22E-04 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 1,167E-06 1,167E-04 ! regulation of insulin secretion GO:0050796 26 21 3,000 1,264E-06 1,212E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 1,687E-06 1,552E-04 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 2,036E-06 1,801E-04 ! regulation of peptide secretion GO:0002791 34 25 3,000 2,641E-06 2,249E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 3,249E-06 2,669E-04 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 3,249E-06 2,577E-04 ! activation of MAPK activity GO:0000187 84 59 4,000 3,508E-06 2,69E-04 ! negative regulation of protein transport GO:0051224 49 27 3,000 3,642E-06 2,702E-04 ! triglyceride metabolic process GO:0006641 34 28 3,000 4,236E-06 3,045E-04 ! cell cycle checkpoint GO:0000075 108 64 4,000 5,262E-06 3,668E-04 ! negative regulation of secretion GO:0051048 49 31 3,000 6,452E-06 4,365E-04 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 2,000 6,923E-06 4,549E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 2,000 6,923E-06 4,423E-04 ! response to X-ray GO:0010165 16 10 2,000 6,923E-06 4,304E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 6,923E-06 4,19E-04 ! cytoplasmic sequestering of protein GO:0051220 14 10 2,000 6,923E-06 4,083E-04 ! neutral lipid metabolic process GO:0006638 41 32 3,000 7,352E-06 4,227E-04 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 48 32 3,000 7,352E-06 4,124E-04 ! androgen receptor signaling pathway GO:0030521 54 33 3,000 8,341E-06 4,568E-04 ! glycerol ether metabolic process GO:0006662 44 34 3,000 9,425E-06 5,041E-04 ! double-strand break repair via homologous recombination GO:0000724 16 11 2,000 9,492E-06 4,962E-04 GO:0000725|recombinational repair, ! regulation of hormone secretion GO:0046883 48 36 3,000 1,19E-05 6,082E-04 ! organic ether metabolic process GO:0018904 46 36 3,000 1,19E-05 5,95E-04 ! hormone-mediated signaling GO:0009755 49 36 3,000 1,19E-05 5,824E-04 ! response to gamma radiation GO:0010332 20 12 2,000 1,262E-05 6,047E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,647E-05 7,73E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 1,824E-05 8,393E-04 ! double-strand break repair GO:0006302 67 40 3,000 1,824E-05 8,228E-04 ! inositol metabolic process GO:0006020 20 14 2,000 2,076E-05 9,184E-04 ! Wnt receptor signaling pathway GO:0016055 130 87 4,000 2,378E-05 1,032E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 2,000 2,588E-05 1,102E-03 ! cardiac muscle tissue development GO:0048738 23 15 2,000 2,588E-05 1,082E-03 ! negative regulation of cell migration GO:0030336 92 44 3,000 2,678E-05 1,1E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 2,931E-05 1,183E-03 ! endothelial cell migration GO:0043542 22 16 2,000 3,176E-05 1,26E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 3,793E-05 1,479E-03 ! response to light stimulus GO:0009416 153 96 4,000 3,827E-05 1,467E-03 ! signal complex assembly GO:0007172 29 17 2,000 3,846E-05 1,45E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 3,846E-05 1,427E-03 ! negative regulation of intracellular transport GO:0032387 29 17 2,000 3,846E-05 1,404E-03 ! lipid modification GO:0030258 73 50 3,000 4,463E-05 1,604E-03 ! regulation of multicellular organism growth GO:0040014 65 50 3,000 4,463E-05 1,579E-03 ! positive regulation of secretion GO:0051047 71 51 3,000 4,829E-05 1,683E-03 ! negative regulation of cell motion GO:0051271 104 51 3,000 4,829E-05 1,658E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 5,45E-05 1,843E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 6,393E-05 2,131E-03 ! cell aging GO:0007569 32 21 2,000 7,438E-05 2,444E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 7,438E-05 2,409E-03 ! multicellular organism reproduction GO:0032504 83 57 3,000 7,498E-05 2,395E-03 GO:0048609|reproductive process in a multicellular organism, ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 8,029E-05 2,53E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 8,588E-05 2,669E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 8,588E-05 2,634E-03 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 8,588E-05 2,599E-03 ! protein tetramerization GO:0051262 39 22 2,000 8,588E-05 2,565E-03 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 9,174E-05 2,705E-03 ! meiosis GO:0007126 96 61 3,000 9,788E-05 2,85E-03 GO:0051327|M phase of meiotic cell cycle, ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 9,848E-05 2,831E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 9,848E-05 2,796E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 9,848E-05 2,762E-03 ! meiotic cell cycle GO:0051321 97 62 3,000 1,043E-04 2,891E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 1,111E-04 3,041E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 1,122E-04 3,037E-03 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 1,434E-04 3,834E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,524E-04 4,028E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,524E-04 3,982E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 1,524E-04 3,937E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 1,524E-04 3,894E-03 ! neuronal ion channel clustering GO:0045161 7 5 1,000 1,524E-04 3,851E-03 ! centrosome duplication GO:0051298 5 5 1,000 1,524E-04 3,809E-03 ! response to UV-C GO:0010225 6 5 1,000 1,524E-04 3,768E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,524E-04 3,728E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 1,608E-04 3,894E-03 ! regulation of catabolic process GO:0009894 106 70 3,000 1,675E-04 4,012E-03 ! positive regulation of catabolic process GO:0009896 40 28 2,000 1,796E-04 4,259E-03 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 1,998E-04 4,689E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 2,28E-04 5,296E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 2,28E-04 5,243E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 2,28E-04 5,191E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 2,28E-04 5,14E-03 ! activation of MAPKKK activity GO:0000185 10 6 1,000 2,28E-04 5,09E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 2,28E-04 5,041E-03 ! ER overload response GO:0006983 7 6 1,000 2,28E-04 4,993E-03 ! male sex determination GO:0030238 9 6 1,000 2,28E-04 4,946E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 2,28E-04 4,9E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 2,28E-04 4,855E-03 ! axonal fasciculation GO:0007413 9 6 1,000 2,28E-04 4,81E-03 ! blastocyst growth GO:0001832 15 6 1,000 2,28E-04 4,766E-03 ! mammary gland development GO:0030879 57 31 2,000 2,444E-04 5,063E-03 ! maintenance of protein location in cell GO:0032507 60 31 2,000 2,444E-04 5,018E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 2,689E-04 5,473E-03 ! negative regulation of cell adhesion GO:0007162 67 33 2,000 2,949E-04 5,951E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 3,183E-04 6,366E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 3,183E-04 6,312E-03 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 3,183E-04 6,258E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 3,183E-04 6,205E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 3,183E-04 6,152E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 3,183E-04 6,101E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 3,183E-04 6,051E-03 ! response to tumor cell GO:0002347 12 7 1,000 3,183E-04 6,001E-03 ! polyol metabolic process GO:0019751 44 34 2,000 3,226E-04 6,032E-03 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 3,226E-04 5,983E-03 ! regulation of cell adhesion GO:0030155 159 83 3,000 3,229E-04 5,942E-03 ! maintenance of protein location GO:0045185 65 35 2,000 3,518E-04 6,422E-03 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 3,537E-04 6,406E-03 ! cell cycle arrest GO:0007050 150 86 3,000 3,699E-04 6,646E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 4,233E-04 7,548E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 4,233E-04 7,49E-03 ! cell proliferation in forebrain GO:0021846 10 8 1,000 4,233E-04 7,433E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 4,233E-04 7,376E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 4,233E-04 7,321E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 4,233E-04 7,266E-03 ! multicellular organism growth GO:0035264 14 8 1,000 4,233E-04 7,213E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 4,233E-04 7,16E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 4,233E-04 7,107E-03 ! hormone metabolic process GO:0042445 121 90 3,000 4,398E-04 7,33E-03 ! maintenance of location in cell GO:0051651 69 38 2,000 4,496E-04 7,44E-03 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 4,781E-04 7,855E-03 ! synapse organization GO:0050808 55 39 2,000 4,857E-04 7,923E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 5,429E-04 8,794E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 5,429E-04 8,732E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 5,429E-04 8,672E-03 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 5,429E-04 8,612E-03 ! receptor clustering GO:0043113 15 9 1,000 5,429E-04 8,553E-03 ! motor axon guidance GO:0008045 14 9 1,000 5,429E-04 8,495E-03 ! oocyte differentiation GO:0009994 12 9 1,000 5,429E-04 8,437E-03 GO:0048599|oocyte development, ! nucleus localization GO:0051647 15 9 1,000 5,429E-04 8,381E-03 ! localization within membrane GO:0051668 15 9 1,000 5,429E-04 8,325E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 6,486E-04 9,879E-03 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 6,486E-04 9,814E-03 ! response to insulin stimulus GO:0032868 63 43 2,000 6,486E-04 9,75E-03 ! regulation of B cell proliferation GO:0030888 15 10 1,000 6,769E-04 0,01010973 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 6,769E-04 0,0100445 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 6,769E-04 9,98E-03 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 6,769E-04 9,917E-03 ! positive regulation of neuron differentiation GO:0045666 12 10 1,000 6,769E-04 9,854E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 6,769E-04 9,792E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of mast cell proliferation GO:0070666 64 44 2,000 6,941E-04 9,977E-03 ! positive regulation of cell cycle GO:0045787 77 45 2,000 7,416E-04 0,0105936 ! cell maturation GO:0048469 60 45 2,000 7,416E-04 0,01052821 ! virus-host interaction GO:0019048 17 11 1,000 8,252E-04 0,01164432 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 8,252E-04 0,01157332 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 8,252E-04 0,01150318 ! regulation of mRNA processing GO:0050684 18 11 1,000 8,252E-04 0,01143388 ! regulation of intracellular pH GO:0051453 17 11 1,000 8,252E-04 0,01136541 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 8,252E-04 0,01129776 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 8,252E-04 0,01123091 GO:0042130|negative regulation of T cell proliferation, ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 8,426E-04 0,01140006 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! maintenance of location GO:0051235 84 49 2,000 9,52E-04 0,01280501 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 9,877E-04 0,01320828 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 9,877E-04 0,01313193 ! cell-cell junction assembly GO:0007043 18 12 1,000 9,877E-04 0,01305646 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 9,877E-04 0,01298185 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 9,877E-04 0,01290809 ! peptidyl-lysine modification GO:0018205 18 12 1,000 9,877E-04 0,01283516 ! positive regulation of cell migration GO:0030335 92 51 2,000 1,07E-03 0,01382645 ! regulation of protein catabolic process GO:0042176 77 51 2,000 1,07E-03 0,01374921 ! aging GO:0007568 79 52 2,000 1,132E-03 0,01446913 ! nucleotide-excision repair GO:0006289 64 52 2,000 1,132E-03 0,01438919 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,164E-03 0,01471451 ! bone mineralization GO:0030282 15 13 1,000 1,164E-03 0,0146341 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 1,164E-03 0,01455457 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,164E-03 0,0144759 ! regulation of cellular pH GO:0030641 20 13 1,000 1,164E-03 0,01439807 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,164E-03 0,01432107 ! regulation of axon extension GO:0030516 23 13 1,000 1,164E-03 0,0142449 ! neuron maturation GO:0042551 21 14 1,000 1,355E-03 0,016489 ! regulation of S phase GO:0033261 18 14 1,000 1,355E-03 0,01640222 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,355E-03 0,01631634 ! activation of MAPKK activity GO:0000186 21 14 1,000 1,355E-03 0,01623136 ! cellular response to starvation GO:0009267 21 14 1,000 1,355E-03 0,01614726 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,355E-03 0,01606403 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,355E-03 0,01598165 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,355E-03 0,01590011 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 1,355E-03 0,0158194 ! positive regulation of cell motion GO:0051272 99 56 2,000 1,404E-03 0,01631402 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 1,478E-03 0,01708567 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 1,478E-03 0,01700025 ! developmental maturation GO:0021700 75 57 2,000 1,478E-03 0,01691567 ! negative regulation of kinase activity GO:0033673 100 58 2,000 1,555E-03 0,01770016 ! lipid phosphorylation GO:0046834 23 15 1,000 1,559E-03 0,01766854 ! centrosome cycle GO:0007098 16 15 1,000 1,559E-03 0,01758193 ! cerebral cortex development GO:0021987 29 15 1,000 1,559E-03 0,01749616 ! neuron recognition GO:0008038 22 15 1,000 1,559E-03 0,01741123 ! biomineral formation GO:0031214 18 15 1,000 1,559E-03 0,01732712 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 1,559E-03 0,01724381 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,559E-03 0,01716131 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,778E-03 0,01946983 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,778E-03 0,01937756 ! oogenesis GO:0048477 23 16 1,000 1,778E-03 0,01928615 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,778E-03 0,01919561 ! negative regulation of translation GO:0017148 22 16 1,000 1,778E-03 0,01910591 ! cell-matrix adhesion GO:0007160 114 61 2,000 1,798E-03 0,01923393 ! negative regulation of transferase activity GO:0051348 105 61 2,000 1,798E-03 0,01914489 ! negative regulation of cell growth GO:0030308 106 62 2,000 1,884E-03 0,01996942 ! regulation of transcription factor activity GO:0051090 97 63 2,000 1,973E-03 0,02081312 GO:0090046|regulation of transcription regulator activity, ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 2,01E-03 0,02110514 ! neuromuscular junction development GO:0007528 23 17 1,000 2,01E-03 0,0210092 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 2,01E-03 0,02091414 ! synaptogenesis GO:0007416 24 17 1,000 2,01E-03 0,02081993 ! cell-cell junction organization GO:0045216 25 17 1,000 2,01E-03 0,02072657 ! negative regulation of cell size GO:0045792 108 64 2,000 2,064E-03 0,02119215 ! protein oligomerization GO:0051259 100 65 2,000 2,158E-03 0,02205676 ! cell-substrate adhesion GO:0031589 121 66 2,000 2,254E-03 0,02294029 ! positive regulation of DNA replication GO:0045740 29 18 1,000 2,255E-03 0,02284822 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 2,255E-03 0,02274801 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 2,255E-03 0,02264867 ! somitogenesis GO:0001756 24 18 1,000 2,255E-03 0,0225502 ! cellular response to nutrient levels GO:0031669 27 18 1,000 2,255E-03 0,02245258 ! negative regulation of T cell activation GO:0050868 25 18 1,000 2,255E-03 0,0223558 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 2,255E-03 0,02225986 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 2,514E-03 0,02470933 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 2,514E-03 0,02460418 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 2,514E-03 0,02449992 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 2,514E-03 0,02439655 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 2,514E-03 0,02429404 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 2,514E-03 0,02419239 ! response to starvation GO:0042594 30 19 1,000 2,514E-03 0,02409159 ! sex determination GO:0007530 29 19 1,000 2,514E-03 0,02399163 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 2,514E-03 0,02389249 ! protein stabilization GO:0050821 26 19 1,000 2,514E-03 0,02379417 ! pallium development GO:0021543 38 20 1,000 2,786E-03 0,02626265 ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,786E-03 0,02615545 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 3,072E-03 0,02871794 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 3,072E-03 0,02860168 ! protein amino acid acylation GO:0043543 37 21 1,000 3,072E-03 0,02848635 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 3,072E-03 0,02837195 ! negative regulation of growth GO:0045926 123 75 2,000 3,243E-03 0,02983814 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 3,37E-03 0,03088177 ! microtubule organizing center organization GO:0031023 28 22 1,000 3,37E-03 0,03075922 GO:0051297|centrosome organization, ! blastocyst development GO:0001824 37 22 1,000 3,37E-03 0,03063764 ! regulation of DNA binding GO:0051101 119 77 2,000 3,494E-03 0,0316367 ! gland development GO:0048732 148 77 2,000 3,494E-03 0,03151264 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 3,682E-03 0,03307802 ! myelination GO:0042552 35 23 1,000 3,682E-03 0,03294931 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 3,682E-03 0,0328216 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 3,682E-03 0,03269488 ! interaction with host GO:0051701 37 23 1,000 3,682E-03 0,03256913 ! cellular response to oxidative stress GO:0034599 33 23 1,000 3,682E-03 0,03244434 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 3,682E-03 0,03232051 ! negative regulation of catabolic process GO:0009895 34 23 1,000 3,682E-03 0,03219762 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 4,006E-03 0,03490274 ! mitochondrial membrane organization GO:0007006 39 24 1,000 4,006E-03 0,03477103 ! receptor metabolic process GO:0043112 37 24 1,000 4,006E-03 0,03464031 ! negative regulation of cell development GO:0010721 56 24 1,000 4,006E-03 0,03451057 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 4,006E-03 0,0343818 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 4,006E-03 0,03425399 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 4,006E-03 0,03412712 ! ossification GO:0001503 134 82 2,000 4,171E-03 0,03539898 GO:0060348|bone development, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 4,344E-03 0,03672843 GO:0045936|negative regulation of phosphate metabolic process, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 4,344E-03 0,03659389 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 4,344E-03 0,03646034 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 4,463E-03 0,03732294 ! regulation of pH GO:0006885 36 26 1,000 4,694E-03 0,03911292 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 4,694E-03 0,03897172 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 4,766E-03 0,03943265 ! skeletal muscle tissue development GO:0007519 123 87 2,000 4,923E-03 0,04058077 GO:0060538|skeletal muscle organ development, ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 5,056E-03 0,04153281 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 5,056E-03 0,04138501 GO:0043433|negative regulation of transcription factor activity, ! interphase GO:0051325 159 88 2,000 5,082E-03 0,04144986 ! regulation of neurogenesis GO:0050767 153 89 2,000 5,245E-03 0,0426247 ! reproductive developmental process GO:0003006 127 89 2,000 5,245E-03 0,04247462 ! cell junction assembly GO:0034329 56 28 1,000 5,431E-03 0,04383145 ! response to organic cyclic substance GO:0014070 47 28 1,000 5,431E-03 0,04367819 ! ensheathment of neurons GO:0007272 43 28 1,000 5,431E-03 0,043526 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 1,000 5,431E-03 0,04337487 ! DNA recombination GO:0006310 146 92 2,000 5,751E-03 0,04577025 ! regulation of axonogenesis GO:0050770 51 29 1,000 5,819E-03 0,04614917 ! telencephalon development GO:0021537 52 29 1,000 5,819E-03 0,04599058 ! tissue homeostasis GO:0001894 42 29 1,000 5,819E-03 0,04583308 GO:0048871|multicellular organismal homeostasis, ! peptidyl-amino acid modification GO:0018193 147 93 2,000 5,926E-03 0,0465199 ! spindle organization GO:0007051 37 30 1,000 6,219E-03 0,04864912 ! regulation of microtubule-based process GO:0032886 58 30 1,000 6,219E-03 0,04848421 ! negative regulation of cell activation GO:0050866 44 30 1,000 6,219E-03 0,04832041 ! regulation of binding GO:0051098 151 95 2,000 6,286E-03 0,0486791 ! angiogenesis GO:0001525 149 95 2,000 6,286E-03 0,04851575 ! in utero embryonic development GO:0001701 147 96 2,000 6,471E-03 0,04977389 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 6,471E-03 0,04960797 ! segmentation GO:0035282 41 31 1,000 6,631E-03 0,05066605 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 6,631E-03 0,05049829 ! extracellular structure organization GO:0043062 156 99 2,000 7,044E-03 0,0534685 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 7,055E-03 0,05337484 ! peripheral nervous system development GO:0007422 53 32 1,000 7,055E-03 0,05319984 ! calcium-mediated signaling GO:0019722 50 32 1,000 7,055E-03 0,05302599 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 7,055E-03 0,05285326 ! cell junction organization GO:0034330 63 33 1,000 7,491E-03 0,05593838 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 7,491E-03 0,05575735 ! cytokinesis GO:0000910 52 33 1,000 7,491E-03 0,05557749 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 7,491E-03 0,05539878 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 7,491E-03 0,05522122 ! female gonad development GO:0008585 49 33 1,000 7,491E-03 0,0550448 ! negative regulation of DNA binding GO:0043392 54 33 1,000 7,491E-03 0,0548695 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 7,939E-03 0,05796656 ! regulation of neuron projection development GO:0010975 63 34 1,000 7,939E-03 0,05778312 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 7,939E-03 0,05760084 ! neuron migration GO:0001764 46 34 1,000 7,939E-03 0,0574197 ! female gamete generation GO:0007292 43 34 1,000 7,939E-03 0,0572397 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 7,939E-03 0,05706083 ! regulation of action potential in neuron GO:0019228 54 35 1,000 8,399E-03 0,06017775 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 8,399E-03 0,05999087 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 8,87E-03 0,06316278 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 8,87E-03 0,06296783 ! negative regulation of binding GO:0051100 58 36 1,000 8,87E-03 0,06277408 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 8,87E-03 0,06258152 GO:0046660|female sex differentiation, ! learning GO:0007612 67 37 1,000 9,353E-03 0,06578837 ! regulation of T cell proliferation GO:0042129 58 38 1,000 9,848E-03 0,06905639 ! mesenchymal cell development GO:0014031 64 38 1,000 9,848E-03 0,0688465 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! developmental growth GO:0048589 62 39 1,000 0,01035411 0,07216503 ! cell growth GO:0016049 61 39 1,000 0,01035411 0,071947 ! T cell differentiation GO:0030217 65 40 1,000 0,01087151 0,07531465 ! B cell differentiation GO:0030183 62 40 1,000 0,01087151 0,07508848 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01087151 0,07486366 ! endosome transport GO:0016197 71 41 1,000 0,01140013 0,07826952 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01140013 0,07803658 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,01140013 0,07780502 ! mitochondrial transport GO:0006839 60 42 1,000 0,01193988 0,08124771 ! positive regulation of binding GO:0051099 59 43 1,000 0,01249068 0,084745 ! activation of caspase activity GO:0006919 65 43 1,000 0,01249068 0,08449575 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,01249068 0,08424797 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,01305242 0,08777943 ! regulation of action potential GO:0001508 71 44 1,000 0,01305242 0,08752352 ! cell recognition GO:0008037 58 45 1,000 0,01362502 0,09109751 ! histone modification GO:0016570 68 46 1,000 0,01420838 0,09472254 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,01480241 0,09839755 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01480241 0,09811399 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,01480241 0,09783205 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,01480241 0,09755173 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01540703 0,1012462 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 1,000 0,01540703 0,10095775 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,01540703 0,10067093 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,01602214 0,10439352 ! germ cell development GO:0007281 68 49 1,000 0,01602214 0,10409863 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,01664764 0,10785798 ! positive regulation of growth GO:0045927 67 50 1,000 0,01664764 0,10755501 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01728347 0,11135005 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,01728347 0,11103902 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01792951 0,11486872 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01925192 0,12299835 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01925192 0,12265763 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01958164 0,12441373 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01958164 0,12407099 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01958164 0,12373014 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01958164 0,12339115 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01958164 0,12305402 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01958164 0,12271872 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01958164 0,12238524 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01958164 0,12205358 ! sleep GO:0030431 11 5 0,000 0,01958164 0,1217237 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01958164 0,12139561 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01958164 0,12106927 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01958164 0,12074469 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01958164 0,12042184 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01958164 0,12010072 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01958164 0,1197813 ! tongue development GO:0043586 6 5 0,000 0,01958164 0,11946358 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01958164 0,11914754 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01958164 0,11883316 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01958164 0,11852045 ! cobalt ion transport GO:0006824 9 5 0,000 0,01958164 0,11820937 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01958164 0,11789992 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01958164 0,11759209 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01958164 0,11728586 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01958164 0,11698122 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01958164 0,11667816 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01958164 0,11637667 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01958164 0,11607673 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01958164 0,11577833 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01958164 0,11548146 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01958164 0,11518611 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01958164 0,11489227 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01958164 0,11459992 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01958164 0,11430906 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01958164 0,11401967 ! malate metabolic process GO:0006108 7 5 0,000 0,01958164 0,11373174 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01958164 0,11344526 ! behavioral response to pain GO:0048266 7 5 0,000 0,01958164 0,11316022 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01958164 0,11287662 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01958164 0,11259442 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01958164 0,11231364 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01958164 0,11203425 ! mating behavior GO:0007617 6 5 0,000 0,01958164 0,11175625 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01958164 0,11147963 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01958164 0,11120437 ! rhythmic behavior GO:0007622 12 5 0,000 0,01958164 0,11093047 ! copulation GO:0007620 7 5 0,000 0,01958164 0,11065791 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01958164 0,11038669 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01958164 0,1101168 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01958164 0,10984822 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01958164 0,10958095 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01958164 0,10931497 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01958164 0,10905029 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01958164 0,10878688 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01958164 0,10852475 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01958164 0,10826387 ! response to protozoan GO:0001562 9 5 0,000 0,01958164 0,10800424 ! lymph vessel development GO:0001945 7 5 0,000 0,01958164 0,10774586 ! endochondral ossification GO:0001958 12 5 0,000 0,01958164 0,10748871 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01958164 0,10723278 ! parathyroid gland development GO:0060017 8 5 0,000 0,01958164 0,10697807 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01958164 0,10672457 ! anagen GO:0042640 6 5 0,000 0,01958164 0,10647227 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01958164 0,10622115 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01958164 0,10597122 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01958164 0,10572246 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01958164 0,10547487 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01958164 0,10522843 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01958164 0,10498315 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01958164 0,104739 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01958164 0,10449598 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01958164 0,1042541 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01958164 0,10401332 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01958164 0,10377366 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01958164 0,1035351 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01958164 0,10329764 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01958164 0,10306126 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01958164 0,10282596 ! ovulation GO:0030728 6 5 0,000 0,01958164 0,10259173 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01958164 0,10235857 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01958164 0,10212646 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01958164 0,10189541 ! response to pH GO:0009268 9 5 0,000 0,01958164 0,10166539 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01958164 0,10143642 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01958164 0,10120847 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01958164 0,10098155 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01958164 0,10075564 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01958164 0,10053074 ! polyol catabolic process GO:0046174 7 5 0,000 0,01958164 0,10030684 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01958164 0,10008393 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01958164 0,09986202 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01958164 0,09964108 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01958164 0,09942112 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01958164 0,09920214 ! urea metabolic process GO:0019627 6 5 0,000 0,01958164 0,09898411 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01958164 0,09876704 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01958164 0,09855092 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01958164 0,09833574 ! neutrophil activation GO:0042119 5 5 0,000 0,01958164 0,0981215 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01958164 0,09790819 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01958164 0,09769581 ! response to food GO:0032094 5 5 0,000 0,01958164 0,09748435 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01958164 0,0972738 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01958164 0,09706416 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01958164 0,09685542 ! forebrain neuron development GO:0021884 7 5 0,000 0,01958164 0,09664757 ! melanosome organization GO:0032438 7 5 0,000 0,01958164 0,09644062 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01958164 0,09623455 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01958164 0,09602936 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01958164 0,09582504 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01958164 0,09562159 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01958164 0,095419 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01958164 0,09521727 ! nucleoside transport GO:0015858 6 5 0,000 0,01958164 0,09501639 ! nucleoside salvage GO:0043174 7 5 0,000 0,01958164 0,09481636 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01958164 0,09461716 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01958164 0,0944188 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01958164 0,09422128 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01958164 0,09402457 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01958164 0,09382869 ! depyrimidination GO:0045008 8 5 0,000 0,01958164 0,09363362 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01958164 0,09343936 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01958164 0,0932459 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01958164 0,09305324 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01958164 0,09286138 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01958164 0,09267031 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01958164 0,09248002 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01958164 0,09229051 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01958164 0,09210178 ! monocyte differentiation GO:0030224 8 5 0,000 0,01958164 0,09191382 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01958164 0,09172662 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01958164 0,09154018 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01958164 0,0913545 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01958164 0,09116957 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01958164 0,09098539 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01958164 0,09080195 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01958164 0,09061925 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01958164 0,09043729 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01958164 0,09025605 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01958164 0,09007554 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01958164 0,08989575 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01958164 0,08971667 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01958164 0,08953831 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01958164 0,08936065 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01958164 0,0891837 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01958164 0,08900745 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01958164 0,08883189 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01958164 0,08865703 ! neural tube patterning GO:0021532 6 5 0,000 0,01958164 0,08848285 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01958164 0,08830935 ! histone demethylation GO:0016577 9 5 0,000 0,01958164 0,08813654 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01958164 0,08796439 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01958164 0,08779292 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01958164 0,08762212 ! enteric nervous system development GO:0048484 8 5 0,000 0,01958164 0,08745198 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01958164 0,0872825 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01958164 0,08711367 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01958164 0,0869455 ! transcription termination GO:0006353 8 5 0,000 0,01958164 0,08677798 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01958164 0,0866111 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01958164 0,08644486 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01958164 0,08627925 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01958164 0,08611428 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01958164 0,08594994 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01958164 0,08578623 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01958164 0,08562314 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01958164 0,08546066 ! apical protein localization GO:0045176 6 5 0,000 0,01958164 0,08529881 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01958164 0,08513756 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01958164 0,08497692 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01958164 0,08481689 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01958164 0,08465746 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01958164 0,08449863 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01958164 0,08434039 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01958164 0,08418275 ! glial cell migration GO:0008347 10 5 0,000 0,01958164 0,08402569 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01958164 0,08386922 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01958164 0,08371333 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01958164 0,08355801 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01958164 0,08340328 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01958164 0,08324911 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01958164 0,08309552 ! neural plate development GO:0001840 6 5 0,000 0,01958164 0,08294249 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01958164 0,08279002 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01958164 0,08263811 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01958164 0,08248676 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01958164 0,08233596 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01958164 0,08218571 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01958164 0,08203601 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01958164 0,08188685 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01958164 0,08173824 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01958164 0,08159016 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01958164 0,08144262 ! spindle assembly GO:0051225 5 5 0,000 0,01958164 0,08129561 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01958164 0,08114913 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01958164 0,08100318 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01958164 0,08085775 ! organ regeneration GO:0031100 7 5 0,000 0,01958164 0,08071285 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01958164 0,08056846 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01958164 0,08042459 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01958164 0,08028123 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01958164 0,08013838 GO:0055081|anion homeostasis, ! gonad development GO:0008406 79 57 1,000 0,02131002 0,0870569 ! viral reproductive process GO:0022415 87 58 1,000 0,02201557 0,0897798 ! lung development GO:0030324 94 59 1,000 0,02273074 0,09253221 ! actin filament organization GO:0007015 95 59 1,000 0,02273074 0,09236873 ! tRNA transcription GO:0009304 11 6 0,000 0,02345238 0,09513309 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02345238 0,09496561 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02345238 0,09479871 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02345238 0,09463239 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02345238 0,09446666 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02345238 0,09430151 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02345238 0,09413694 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02345238 0,09397293 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02345238 0,0938095 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02345238 0,09364664 ! prostate gland development GO:0030850 9 6 0,000 0,02345238 0,09348434 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02345238 0,0933226 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02345238 0,09316142 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02345238 0,0930008 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02345238 0,09284073 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02345238 0,09268121 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02345238 0,09252224 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02345238 0,09236381 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,02345238 0,09220592 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02345238 0,09204857 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02345238 0,09189176 ! signal peptide processing GO:0006465 8 6 0,000 0,02345238 0,09173548 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02345238 0,09157974 ! mRNA stabilization GO:0048255 15 6 0,000 0,02345238 0,09142452 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02345238 0,09126982 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02345238 0,09111565 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02345238 0,090962 ! opsonization GO:0008228 8 6 0,000 0,02345238 0,09080886 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02345238 0,09065624 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02345238 0,09050413 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02345238 0,09035254 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02345238 0,09020145 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02345238 0,09005086 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02345238 0,08990077 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02345238 0,08975119 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02345238 0,0896021 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02345238 0,08945351 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02345238 0,0893054 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02345238 0,08915779 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02345238 0,08901067 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02345238 0,08886403 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02345238 0,08871787 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02345238 0,08857219 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02345238 0,08842699 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02345238 0,08828227 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02345238 0,08813801 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02345238 0,08799423 ! thymic T cell selection GO:0045061 12 6 0,000 0,02345238 0,08785092 ! protein lipoylation GO:0009249 10 6 0,000 0,02345238 0,08770807 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02345238 0,08756569 ! pigment granule organization GO:0048753 11 6 0,000 0,02345238 0,08742377 ! drug transport GO:0015893 6 6 0,000 0,02345238 0,0872823 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02345238 0,0871413 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02345238 0,08700075 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02345238 0,08686065 ! histidine metabolic process GO:0006547 6 6 0,000 0,02345238 0,086721 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02345238 0,0865818 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02345238 0,08644305 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02345238 0,08630474 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02345238 0,08616688 ! adenohypophysis development GO:0021984 10 6 0,000 0,02345238 0,08602945 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02345238 0,08589246 ! hyperosmotic response GO:0006972 8 6 0,000 0,02345238 0,0857559 ! microtubule nucleation GO:0007020 10 6 0,000 0,02345238 0,08561978 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02345238 0,0854841 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02345238 0,08534884 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02345238 0,085214 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02345238 0,0850796 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02345238 0,08494561 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02345238 0,08481205 ! response to dietary excess GO:0002021 7 6 0,000 0,02345238 0,08467891 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02345238 0,08454618 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02345238 0,08441387 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02345238 0,08428198 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02345238 0,08415049 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02345238 0,08401941 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02345238 0,08388875 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02345238 0,08375848 ! neuron apoptosis GO:0051402 8 6 0,000 0,02345238 0,08362863 ! organic alcohol transport GO:0015850 9 6 0,000 0,02345238 0,08349917 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02345238 0,08337011 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02345238 0,08324146 ! carnitine transport GO:0015879 8 6 0,000 0,02345238 0,0831132 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02345238 0,08298533 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02345238 0,08285786 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02345238 0,08273077 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02345238 0,08260408 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02345238 0,08247777 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02345238 0,08235185 ! parturition GO:0007567 12 6 0,000 0,02345238 0,08222632 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02345238 0,08210116 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02345238 0,08197639 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02345238 0,08185199 ! spindle checkpoint GO:0031577 14 6 0,000 0,02345238 0,08172798 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02345238 0,08160433 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02345238 0,08148106 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02345238 0,08135817 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02345238 0,08123564 ! macrophage differentiation GO:0030225 10 6 0,000 0,02345238 0,08111348 ! astrocyte development GO:0014002 14 6 0,000 0,02345238 0,08099169 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02345238 0,08087026 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02345238 0,0807492 ! interaction with symbiont GO:0051702 8 6 0,000 0,02345238 0,0806285 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02345238 0,08050816 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02345238 0,08038817 ! eating behavior GO:0042755 6 6 0,000 0,02345238 0,08026855 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02345238 0,08014928 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02345238 0,08003036 ! response to copper ion GO:0046688 9 6 0,000 0,02345238 0,0799118 ! DNA topological change GO:0006265 8 6 0,000 0,02345238 0,07979359 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02345238 0,07967572 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02345238 0,07955821 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02345238 0,07944104 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02345238 0,07932421 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02345238 0,07920773 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02345238 0,07909159 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02345238 0,07897579 ! gas homeostasis GO:0033483 11 6 0,000 0,02345238 0,07886033 ! hair follicle maturation GO:0048820 7 6 0,000 0,02345238 0,0787452 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02345238 0,07863041 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02345238 0,07851596 ! Schwann cell development GO:0014044 14 6 0,000 0,02345238 0,07840184 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02345238 0,07828805 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02345238 0,07817459 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02345238 0,07806145 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02345238 0,07794865 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02345238 0,07783617 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02345238 0,07772401 ! histone ubiquitination GO:0016574 7 6 0,000 0,02345238 0,07761218 ! regulation of meiosis GO:0040020 10 6 0,000 0,02345238 0,07750067 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02345238 0,07738948 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02345238 0,0772786 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02345238 0,07716805 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02345238 0,07705781 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02345238 0,07694788 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02345238 0,07683827 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02345238 0,07672897 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02345238 0,07661998 ! receptor internalization GO:0031623 9 6 0,000 0,02345238 0,0765113 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02345238 0,07640292 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02345238 0,07629486 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02345238 0,0761871 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02345238 0,07607964 ! protein deubiquitination GO:0016579 8 6 0,000 0,02345238 0,07597248 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02345238 0,07586563 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02345238 0,07575908 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02345238 0,07565282 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02345238 0,07554687 ! midbrain development GO:0030901 6 6 0,000 0,02345238 0,07544121 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02345238 0,07533584 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02345238 0,07523077 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02345238 0,07512599 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02345238 0,07502151 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02345238 0,07491731 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02345238 0,0748134 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02345238 0,07470978 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02345238 0,07460645 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02345238 0,0745034 ! adult feeding behavior GO:0008343 6 6 0,000 0,02345238 0,07440064 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02345238 0,07429816 ! pigment granule transport GO:0051904 12 6 0,000 0,02345238 0,07419596 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02345238 0,07409404 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02345238 0,07399241 ! catecholamine transport GO:0051937 7 6 0,000 0,02345238 0,07389105 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02345238 0,07378996 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02345238 0,07368916 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02345238 0,07358863 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02345238 0,07348837 ! protein prenylation GO:0018342 10 6 0,000 0,02345238 0,07338839 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02345238 0,07328867 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02345238 0,07318923 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02345238 0,07309006 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02345238 0,07299116 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02345238 0,07289252 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,02345544 0,07280367 ! respiratory tube development GO:0030323 99 62 1,000 0,02493311 0,07728593 ! organelle localization GO:0051640 96 62 1,000 0,02493311 0,07718191 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,02568591 0,07940537 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,02568591 0,07929879 ! viral reproduction GO:0016032 92 63 1,000 0,02568591 0,07919249 ! regulation of lipase activity GO:0060191 109 63 1,000 0,02568591 0,07908648 ! respiratory system development GO:0060541 100 64 1,000 0,02644791 0,08132379 ! reproductive structure development GO:0048608 90 65 1,000 0,02721903 0,08358313 ! regulation of caspase activity GO:0043281 97 65 1,000 0,02721903 0,08347169 ! B cell activation GO:0042113 104 65 1,000 0,02721903 0,08336054 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02730805 0,08352197 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02730805 0,08341105 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02730805 0,08330042 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02730805 0,08319009 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02730805 0,08308005 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02730805 0,0829703 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02730805 0,08286084 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02730805 0,08275167 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02730805 0,08264279 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02730805 0,08253419 ! reproductive behavior GO:0019098 12 7 0,000 0,02730805 0,08242588 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02730805 0,08231785 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,02730805 0,0822101 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02730805 0,08210264 ! oligopeptide transport GO:0006857 11 7 0,000 0,02730805 0,08199545 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02730805 0,08188855 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02730805 0,08178192 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02730805 0,08167558 ! RNA methylation GO:0001510 11 7 0,000 0,02730805 0,0815695 ! pericardium development GO:0060039 8 7 0,000 0,02730805 0,08146371 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02730805 0,08135818 ! fibril organization GO:0043206 13 7 0,000 0,02730805 0,08125293 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02730805 0,08114796 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02730805 0,08104325 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02730805 0,08093881 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02730805 0,08083464 ! lipoprotein transport GO:0042953 9 7 0,000 0,02730805 0,08073074 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02730805 0,08062711 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02730805 0,08052374 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02730805 0,08042064 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02730805 0,0803178 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02730805 0,08021522 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02730805 0,08011291 ! chemosensory behavior GO:0007635 9 7 0,000 0,02730805 0,08001085 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02730805 0,07990906 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02730805 0,07980752 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02730805 0,07970624 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02730805 0,07960522 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02730805 0,07950445 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02730805 0,07940394 ! reflex GO:0060004 12 7 0,000 0,02730805 0,07930368 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02730805 0,07920368 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02730805 0,07910393 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02730805 0,07900443 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02730805 0,07890517 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02730805 0,07880617 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02730805 0,07870742 ! spinal cord patterning GO:0021511 7 7 0,000 0,02730805 0,07860891 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02730805 0,07851065 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02730805 0,07841263 ! adrenal gland development GO:0030325 17 7 0,000 0,02730805 0,07831486 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02730805 0,07821733 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02730805 0,07812005 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02730805 0,078023 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02730805 0,0779262 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02730805 0,07782964 ! endosome organization GO:0007032 10 7 0,000 0,02730805 0,07773331 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02730805 0,07763723 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02730805 0,07754138 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02730805 0,07744577 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02730805 0,07735039 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02730805 0,07725525 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02730805 0,07716034 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02730805 0,07706567 ! galactose metabolic process GO:0006012 10 7 0,000 0,02730805 0,07697122 ! vesicle fusion GO:0006906 15 7 0,000 0,02730805 0,07687701 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02730805 0,07678303 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02730805 0,07668928 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02730805 0,07659575 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02730805 0,07650246 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02730805 0,07640939 ! retinol metabolic process GO:0042572 9 7 0,000 0,02730805 0,07631655 ! behavioral fear response GO:0001662 13 7 0,000 0,02730805 0,07622393 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02730805 0,07613154 ! rRNA modification GO:0000154 12 7 0,000 0,02730805 0,07603937 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02730805 0,07594742 ! response to UV-B GO:0010224 11 7 0,000 0,02730805 0,0758557 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02730805 0,0757642 ! intermediate filament organization GO:0045109 11 7 0,000 0,02730805 0,07567291 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02730805 0,07558185 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02730805 0,07549101 ! fibrinolysis GO:0042730 9 7 0,000 0,02730805 0,07540038 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,02730805 0,07530997 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02730805 0,07521978 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02730805 0,07512981 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02730805 0,07504005 ! response to tropane GO:0014073 13 7 0,000 0,02730805 0,0749505 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02730805 0,07486117 ! melanosome localization GO:0032400 10 7 0,000 0,02730805 0,07477205 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02730805 0,07468314 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02730805 0,07459444 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02730805 0,07450595 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02730805 0,07441768 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02730805 0,07432961 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02730805 0,07424175 ! mast cell activation GO:0045576 9 7 0,000 0,02730805 0,07415409 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02730805 0,07406665 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02730805 0,07397941 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02730805 0,07389237 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02730805 0,07380554 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02730805 0,07371892 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,02730805 0,07363249 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02730805 0,07354627 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02730805 0,07346025 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02730805 0,07337444 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02730805 0,07328882 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02730805 0,0732034 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02730805 0,07311818 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02730805 0,07303316 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02730805 0,07294834 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02730805 0,07286371 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02730805 0,07277928 ! diuresis GO:0030146 12 7 0,000 0,02730805 0,07269504 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02730805 0,072611 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02730805 0,07252716 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02730805 0,0724435 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02730805 0,07236004 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02730805 0,07227678 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02730805 0,0721937 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02730805 0,07211081 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02730805 0,07202812 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02730805 0,07194561 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02730805 0,07186329 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02730805 0,07178116 ! lymph node development GO:0048535 9 7 0,000 0,02730805 0,07169922 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02730805 0,07161747 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02730805 0,0715359 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02730805 0,07145451 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02730805 0,07137332 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02730805 0,0712923 ! ATP catabolic process GO:0006200 10 7 0,000 0,02730805 0,07121147 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02730805 0,07113082 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02730805 0,07105036 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02730805 0,07097008 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02730805 0,07088998 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02730805 0,07081005 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02730805 0,07073031 ! muscle adaptation GO:0043500 12 7 0,000 0,02730805 0,07065075 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02730805 0,07057137 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02730805 0,07049216 ! retina homeostasis GO:0001895 9 7 0,000 0,02730805 0,07041314 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02730805 0,07033429 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02730805 0,07025561 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02730805 0,07017711 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02730805 0,07009879 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02730805 0,07002064 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02730805 0,06994267 ! axon guidance GO:0007411 99 66 1,000 0,02799918 0,07163306 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,02878829 0,07357007 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,02878829 0,07348842 ! learning or memory GO:0007611 123 68 1,000 0,02958627 0,07544171 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,02958627 0,07535817 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,03039305 0,07732744 ! response to drug GO:0042493 108 69 1,000 0,03039305 0,077242 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03114872 0,07907513 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03114872 0,07898794 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,03114872 0,07890095 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03114872 0,07881415 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03114872 0,07872754 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03114872 0,07864112 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03114872 0,07855489 ! phosphate transport GO:0006817 10 8 0,000 0,03114872 0,07846885 ! N-glycan processing GO:0006491 12 8 0,000 0,03114872 0,078383 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03114872 0,07829734 ! UTP metabolic process GO:0046051 8 8 0,000 0,03114872 0,07821186 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03114872 0,07812657 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03114872 0,07804146 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,03114872 0,07795654 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03114872 0,07787181 ! succinate metabolic process GO:0006105 14 8 0,000 0,03114872 0,07778726 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03114872 0,07770289 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03114872 0,0776187 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03114872 0,0775347 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03114872 0,07745088 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03114872 0,07736724 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03114872 0,07728378 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03114872 0,0772005 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03114872 0,0771174 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03114872 0,07703448 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03114872 0,07695173 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03114872 0,07686917 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03114872 0,07678678 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03114872 0,07670456 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03114872 0,07662253 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03114872 0,07654067 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03114872 0,07645898 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03114872 0,07637747 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03114872 0,07629613 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03114872 0,07621496 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03114872 0,07613397 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03114872 0,07605315 ! melanin metabolic process GO:0006582 12 8 0,000 0,03114872 0,0759725 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03114872 0,07589202 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03114872 0,07581171 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03114872 0,07573157 ! macrophage activation GO:0042116 12 8 0,000 0,03114872 0,0756516 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03114872 0,0755718 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03114872 0,07549216 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03114872 0,0754127 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03114872 0,0753334 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03114872 0,07525427 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03114872 0,0751753 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03114872 0,0750965 ! ruffle organization GO:0031529 11 8 0,000 0,03114872 0,07501787 ! osteoblast development GO:0002076 13 8 0,000 0,03114872 0,0749394 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03114872 0,07486109 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03114872 0,07478295 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03114872 0,07470497 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03114872 0,07462715 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03114872 0,07454949 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03114872 0,074472 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03114872 0,07439467 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03114872 0,07431749 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03114872 0,07424048 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03114872 0,07416363 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03114872 0,07408693 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03114872 0,0740104 ! segment specification GO:0007379 10 8 0,000 0,03114872 0,07393402 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03114872 0,0738578 ! cellular extravasation GO:0045123 11 8 0,000 0,03114872 0,07378173 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03114872 0,07370583 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03114872 0,07363008 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03114872 0,07355448 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03114872 0,07347904 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03114872 0,07340375 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03114872 0,07332862 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03114872 0,07325364 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03114872 0,07317882 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03114872 0,07310415 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03114872 0,07302963 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03114872 0,07295526 ! icosanoid secretion GO:0032309 12 8 0,000 0,03114872 0,07288104 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03114872 0,07280698 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03114872 0,07273306 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03114872 0,07265929 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03114872 0,07258568 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03114872 0,07251221 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03114872 0,07243889 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03114872 0,07236572 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03114872 0,0722927 ! sterol catabolic process GO:0016127 9 8 0,000 0,03114872 0,07221982 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03114872 0,07214709 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03114872 0,07207451 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03114872 0,07200207 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03114872 0,07192978 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03114872 0,07185764 ! prophase GO:0051324 11 8 0,000 0,03114872 0,07178563 ! S phase GO:0051320 8 8 0,000 0,03114872 0,07171378 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03114872 0,07164206 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03114872 0,07157049 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03114872 0,07149907 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03114872 0,07142778 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03114872 0,07135664 ! hormone catabolic process GO:0042447 13 8 0,000 0,03114872 0,07128564 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03114872 0,07121478 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03114872 0,07114406 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03114872 0,07107348 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03114872 0,07100304 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03114872 0,07093274 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03114872 0,07086258 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03114872 0,07079255 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03114872 0,07072267 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03114872 0,07065292 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03114872 0,07058331 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03114872 0,07051384 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03114872 0,07044451 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03114872 0,07037531 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03114872 0,07030625 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03114872 0,07023732 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,03120854 0,07030327 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,03203266 0,07208917 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,03203266 0,0720187 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,03286535 0,07381865 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,03286535 0,07374663 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 1,000 0,03286535 0,07367475 ! mitochondrion organization GO:0007005 104 73 1,000 0,03370651 0,07548682 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,03370651 0,07541339 ! response to oxygen levels GO:0070482 137 74 1,000 0,03455607 0,07723903 ! protein import into nucleus GO:0006606 118 74 1,000 0,03455607 0,07716404 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03455607 0,07708919 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03497445 0,07794693 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03497445 0,07787148 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03497445 0,07779616 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03497445 0,077721 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03497445 0,07764598 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03497445 0,0775711 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,03497445 0,07749637 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03497445 0,07742178 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03497445 0,07734734 ! GTP metabolic process GO:0046039 9 9 0,000 0,03497445 0,07727304 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03497445 0,07719888 ! social behavior GO:0035176 14 9 0,000 0,03497445 0,07712486 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03497445 0,07705099 ! artery development GO:0060840 19 9 0,000 0,03497445 0,07697726 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03497445 0,07690367 ! response to pain GO:0048265 16 9 0,000 0,03497445 0,07683021 ! protein complex disassembly GO:0043241 17 9 0,000 0,03497445 0,0767569 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03497445 0,07668373 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03497445 0,0766107 ! lung alveolus development GO:0048286 17 9 0,000 0,03497445 0,07653781 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03497445 0,07646505 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03497445 0,07639243 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03497445 0,07631996 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03497445 0,07624761 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03497445 0,07617541 ! protein targeting to ER GO:0045047 19 9 0,000 0,03497445 0,07610334 ! T cell selection GO:0045058 18 9 0,000 0,03497445 0,07603141 ! endoderm development GO:0007492 12 9 0,000 0,03497445 0,07595962 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03497445 0,07588796 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03497445 0,07581643 ! arginine catabolic process GO:0006527 10 9 0,000 0,03497445 0,07574504 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03497445 0,07567379 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03497445 0,07560266 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03497445 0,07553167 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03497445 0,07546082 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03497445 0,0753901 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03497445 0,07531951 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03497445 0,07524905 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03497445 0,07517872 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03497445 0,07510853 ! mannose metabolic process GO:0006013 9 9 0,000 0,03497445 0,07503846 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03497445 0,07496853 ! epithelial cell development GO:0002064 10 9 0,000 0,03497445 0,07489873 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03497445 0,07482905 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03497445 0,07475951 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03497445 0,0746901 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03497445 0,07462081 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03497445 0,07455165 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03497445 0,07448262 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03497445 0,07441372 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03497445 0,07434495 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,03497445 0,0742763 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03497445 0,07420778 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03497445 0,07413939 ! DNA ligation GO:0006266 14 9 0,000 0,03497445 0,07407112 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03497445 0,07400297 ! response to amine stimulus GO:0014075 13 9 0,000 0,03497445 0,07393496 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03497445 0,07386706 ! erythrocyte development GO:0048821 11 9 0,000 0,03497445 0,0737993 ! renal water homeostasis GO:0003091 14 9 0,000 0,03497445 0,07373165 ! postreplication repair GO:0006301 11 9 0,000 0,03497445 0,07366413 ! mRNA cleavage GO:0006379 13 9 0,000 0,03497445 0,07359674 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03497445 0,07352946 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03497445 0,07346231 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03497445 0,07339529 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03497445 0,07332838 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03497445 0,0732616 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03497445 0,07319494 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03497445 0,07312839 ! acid secretion GO:0046717 14 9 0,000 0,03497445 0,07306197 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03497445 0,07299567 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03497445 0,0729295 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03497445 0,07286344 ! purine base metabolic process GO:0006144 18 9 0,000 0,03497445 0,0727975 ! thymus development GO:0048538 15 9 0,000 0,03497445 0,07273168 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03497445 0,07266597 ! spleen development GO:0048536 15 9 0,000 0,03497445 0,07260039 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03497445 0,07253493 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03497445 0,07246958 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03497445 0,07240435 ! detection of calcium ion GO:0005513 13 9 0,000 0,03497445 0,07233924 ! blastocyst formation GO:0001825 12 9 0,000 0,03497445 0,07227424 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03497445 0,07220937 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03497445 0,0721446 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03497445 0,07207996 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03497445 0,07201543 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03497445 0,07195101 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03497445 0,07188671 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03497445 0,07182253 ! prepulse inhibition GO:0060134 14 9 0,000 0,03497445 0,07175846 ! embryonic placenta development GO:0001892 12 9 0,000 0,03497445 0,0716945 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03497445 0,07163066 ! insulin secretion GO:0030073 17 9 0,000 0,03497445 0,07156693 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03497445 0,07150332 ! response to nicotine GO:0035094 16 9 0,000 0,03497445 0,07143982 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03497445 0,07137643 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03497445 0,07131315 ! response to nutrient GO:0007584 104 75 1,000 0,03541395 0,07214535 ! nuclear import GO:0051170 121 75 1,000 0,03541395 0,0720815 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,03628009 0,07377913 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,03715439 0,07549036 ! sex differentiation GO:0007548 105 77 1,000 0,03715439 0,07542373 ! protein ubiquitination GO:0016567 125 77 1,000 0,03715439 0,07535722 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,03803678 0,07707894 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03878529 0,07852655 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03878529 0,07845748 ! neuron fate specification GO:0048665 11 10 0,000 0,03878529 0,07838854 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03878529 0,07831972 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03878529 0,07825102 ! thyroid gland development GO:0030878 19 10 0,000 0,03878529 0,07818244 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03878529 0,07811398 ! synapsis GO:0007129 13 10 0,000 0,03878529 0,07804563 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03878529 0,07797741 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03878529 0,07790931 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03878529 0,07784133 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03878529 0,07777346 ! sulfate transport GO:0008272 12 10 0,000 0,03878529 0,07770571 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03878529 0,07763809 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,03878529 0,07757057 ! androgen metabolic process GO:0008209 13 10 0,000 0,03878529 0,07750318 ! phospholipid efflux GO:0033700 16 10 0,000 0,03878529 0,0774359 ! hippocampus development GO:0021766 19 10 0,000 0,03878529 0,07736874 ! blood vessel remodeling GO:0001974 21 10 0,000 0,03878529 0,0773017 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03878529 0,07723477 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03878529 0,07716796 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03878529 0,07710126 ! pathogenesis GO:0009405 13 10 0,000 0,03878529 0,07703468 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03878529 0,07696821 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03878529 0,07690186 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03878529 0,07683562 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03878529 0,0767695 ! melanocyte differentiation GO:0030318 15 10 0,000 0,03878529 0,07670349 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03878529 0,07663759 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,03878529 0,07657181 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03878529 0,07650614 ! B cell proliferation GO:0042100 14 10 0,000 0,03878529 0,07644058 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03878529 0,07637514 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,03878529 0,0763098 ! forebrain cell migration GO:0021885 17 10 0,000 0,03878529 0,07624458 ! lipid digestion GO:0044241 15 10 0,000 0,03878529 0,07617947 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03878529 0,07611447 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03878529 0,07604958 ! UV protection GO:0009650 14 10 0,000 0,03878529 0,0759848 ! entry into host cell GO:0030260 20 10 0,000 0,03878529 0,07592014 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03878529 0,07585558 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03878529 0,07579113 ! negative regulation of ossification GO:0030279 19 10 0,000 0,03878529 0,07572679 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03878529 0,07566256 ! regulation of bone resorption GO:0045124 24 10 0,000 0,03878529 0,07559844 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03878529 0,07553443 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03878529 0,07547052 ! regulation of organ growth GO:0046620 11 10 0,000 0,03878529 0,07540673 ! response to dsRNA GO:0043331 18 10 0,000 0,03878529 0,07534304 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03878529 0,07527946 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03878529 0,07521599 ! embryonic axis specification GO:0000578 12 10 0,000 0,03878529 0,07515262 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03878529 0,07508936 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03878529 0,07502621 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03878529 0,07496316 ! cranial nerve development GO:0021545 12 10 0,000 0,03878529 0,07490022 ! fucose catabolic process GO:0019317 16 10 0,000 0,03878529 0,07483738 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,03878529 0,07477465 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03878529 0,07471203 ! protein sumoylation GO:0016925 12 10 0,000 0,03878529 0,07464951 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03878529 0,07458709 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03878529 0,07452478 ! zymogen activation GO:0031638 14 10 0,000 0,03878529 0,07446257 ! salivary gland development GO:0007431 22 10 0,000 0,03878529 0,07440047 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03878529 0,07433847 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03878529 0,07427657 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03878529 0,07421478 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,03878529 0,07415308 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03878529 0,07409149 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03878529 0,07403001 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03878529 0,07396862 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03878529 0,07390734 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03878529 0,07384616 ! detection of bacterium GO:0016045 10 10 0,000 0,03878529 0,07378508 ! embryonic gut development GO:0048566 11 10 0,000 0,03878529 0,0737241 ! activation of innate immune response GO:0002218 10 10 0,000 0,03878529 0,07366322 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03878529 0,07360244 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03878529 0,07354176 ! developmental induction GO:0031128 13 10 0,000 0,03878529 0,07348119 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,03878529 0,07342071 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03878529 0,07336033 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03878529 0,07330005 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,0389272 0,07350784 ! T cell activation GO:0042110 134 79 1,000 0,0389272 0,07344754 ! regulation of lyase activity GO:0051339 133 79 1,000 0,0389272 0,07338734 ! chromatin assembly GO:0031497 102 80 1,000 0,03982555 0,07501947 GO:0006334|nucleosome assembly, ! protein localization in nucleus GO:0034504 133 80 1,000 0,03982555 0,07495808 ! forebrain development GO:0030900 131 80 1,000 0,03982555 0,07489679 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,04073178 0,07653847 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,04073178 0,07647599 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,04073178 0,07641362 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,04256754 0,07979246 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! rRNA transcription GO:0009303 17 11 0,000 0,04258129 0,07975324 ! respiratory burst GO:0045730 14 11 0,000 0,04258129 0,07968834 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04258129 0,07962356 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04258129 0,07955887 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04258129 0,0794943 ! filopodium assembly GO:0046847 19 11 0,000 0,04258129 0,07942982 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04258129 0,07936546 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04258129 0,07930119 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,04258129 0,07923703 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04258129 0,07917298 ! mating GO:0007618 14 11 0,000 0,04258129 0,07910903 ! T cell proliferation GO:0042098 20 11 0,000 0,04258129 0,07904518 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04258129 0,07898143 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04258129 0,07891779 ! bone resorption GO:0045453 16 11 0,000 0,04258129 0,07885425 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04258129 0,07879081 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04258129 0,07872747 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04258129 0,07866424 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04258129 0,0786011 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04258129 0,07853807 ! syncytium formation GO:0006949 15 11 0,000 0,04258129 0,07847514 ! plasma membrane organization GO:0007009 18 11 0,000 0,04258129 0,07841231 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04258129 0,07834958 ! focal adhesion formation GO:0048041 24 11 0,000 0,04258129 0,07828695 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04258129 0,07822442 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04258129 0,07816199 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04258129 0,07809966 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04258129 0,07803743 ! adult heart development GO:0007512 11 11 0,000 0,04258129 0,0779753 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04258129 0,07791326 ! temperature homeostasis GO:0001659 16 11 0,000 0,04258129 0,07785133 ! L-glutamate transport GO:0015813 16 11 0,000 0,04258129 0,07778949 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04258129 0,07772776 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04258129 0,07766612 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04258129 0,07760457 ! stem cell development GO:0048864 29 11 0,000 0,04258129 0,07754313 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04258129 0,07748178 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04258129 0,07742053 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04258129 0,07735938 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04258129 0,07729832 ! vasoconstriction GO:0042310 15 11 0,000 0,04258129 0,07723736 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04258129 0,0771765 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04258129 0,07711573 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04258129 0,07705505 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04258129 0,07699448 ! ribosome assembly GO:0042255 13 11 0,000 0,04258129 0,07693399 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04258129 0,07687361 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04258129 0,07681331 ! chromatin silencing GO:0006342 19 11 0,000 0,04258129 0,07675311 ! nucleosome positioning GO:0016584 13 11 0,000 0,04258129 0,07669301 ! T cell homeostasis GO:0043029 20 11 0,000 0,04258129 0,076633 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04258129 0,07657308 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04258129 0,07651326 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04258129 0,07645353 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04258129 0,0763939 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04258129 0,07633435 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04258129 0,0762749 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04258129 0,07621554 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04258129 0,07615628 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04258129 0,0760971 ! male genitalia development GO:0030539 13 11 0,000 0,04258129 0,07603802 ! cholesterol efflux GO:0033344 19 11 0,000 0,04258129 0,07597903 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04258129 0,07592013 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04258129 0,07586133 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04258129 0,07580261 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04258129 0,07574399 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04258129 0,07568545 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04258129 0,07562701 ! defense response to fungus GO:0050832 12 11 0,000 0,04258129 0,07556865 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04258129 0,07551039 ! lysogeny GO:0030069 18 11 0,000 0,04258129 0,07545221 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04258129 0,07539413 ! acrosome reaction GO:0007340 13 11 0,000 0,04258129 0,07533613 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04258129 0,07527823 ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,04349693 0,0768379 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,0444339 0,07843282 ! regulation of membrane potential GO:0042391 128 85 1,000 0,0444339 0,07837268 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,04537837 0,0799772 ! nucleosome organization GO:0034728 114 87 1,000 0,04633027 0,08159236 ! lactation GO:0007595 20 12 0,000 0,04636252 0,08158669 ! reproductive cellular process GO:0048610 14 12 0,000 0,04636252 0,08152432 ! tRNA modification GO:0006400 14 12 0,000 0,04636252 0,08146204 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04636252 0,08139985 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04636252 0,08133776 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04636252 0,08127577 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04636252 0,08121387 ! non-recombinational repair GO:0000726 19 12 0,000 0,04636252 0,08115206 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04636252 0,08109035 ! peroxisomal transport GO:0043574 21 12 0,000 0,04636252 0,08102873 ! cartilage condensation GO:0001502 18 12 0,000 0,04636252 0,0809672 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04636252 0,08090577 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04636252 0,08084443 ! heart looping GO:0001947 15 12 0,000 0,04636252 0,08078319 ! palate development GO:0060021 15 12 0,000 0,04636252 0,08072203 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04636252 0,08066097 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04636252 0,0806 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04636252 0,08053913 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04636252 0,08047834 ! arginine metabolic process GO:0006525 13 12 0,000 0,04636252 0,08041765 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04636252 0,08035705 ! methionine metabolic process GO:0006555 13 12 0,000 0,04636252 0,08029654 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04636252 0,08023612 ! Golgi organization GO:0007030 18 12 0,000 0,04636252 0,08017579 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04636252 0,08011556 ! monoamine transport GO:0015844 13 12 0,000 0,04636252 0,08005541 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04636252 0,07999535 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04636252 0,07993539 ! L-amino acid transport GO:0015807 20 12 0,000 0,04636252 0,07987551 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04636252 0,07981572 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04636252 0,07975602 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04636252 0,07969642 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04636252 0,0796369 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04636252 0,07957747 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04636252 0,07951812 ! cerebellum development GO:0021549 13 12 0,000 0,04636252 0,07945887 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04636252 0,07939971 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04636252 0,07934063 ! histone methylation GO:0016571 15 12 0,000 0,04636252 0,07928164 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04636252 0,07922274 ! gland morphogenesis GO:0022612 23 12 0,000 0,04636252 0,07916392 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04636252 0,0791052 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04636252 0,07904656 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04636252 0,078988 ! intestinal absorption GO:0050892 19 12 0,000 0,04636252 0,07892954 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04636252 0,07887116 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04636252 0,07881286 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04636252 0,07875466 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04636252 0,07869654 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,04636252 0,0786385 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04636252 0,07858055 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04636252 0,07852268 ! microspike assembly GO:0030035 23 12 0,000 0,04636252 0,0784649 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04636252 0,07840721 ! response to cold GO:0009409 14 12 0,000 0,04636252 0,0783496 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,04728953 0,0798575 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,04825608 0,08142992 ! regulation of T cell activation GO:0050863 128 89 1,000 0,04825608 0,08137022 ! leukocyte differentiation GO:0002521 143 90 1,000 0,04922984 0,08295138 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,04922984 0,08289066 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,05012904 0,08434293 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,05012904 0,08428128 ! cGMP metabolic process GO:0046068 16 13 0,000 0,05012904 0,08421971 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,05012904 0,08415824 ! water transport GO:0006833 17 13 0,000 0,05012904 0,08409685 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,05012904 0,08403556 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,05012904 0,08397435 ! lipid localization GO:0010876 24 13 0,000 0,05012904 0,08391324 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,05012904 0,08385221 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,05012904 0,08379127 ! organelle fusion GO:0048284 28 13 0,000 0,05012904 0,08373042 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,05012904 0,08366966 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,05012904 0,08360898 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,05012904 0,0835484 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,05012904 0,0834879 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,05012904 0,08342749 ! response to hexose stimulus GO:0009746 19 13 0,000 0,05012904 0,08336716 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,05012904 0,08330693 ! glutamate metabolic process GO:0006536 18 13 0,000 0,05012904 0,08324678 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,05012904 0,08318671 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,05012904 0,08312674 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,05012904 0,08306685 ! NAD metabolic process GO:0019674 21 13 0,000 0,05012904 0,08300705 ! exocrine system development GO:0035272 27 13 0,000 0,05012904 0,08294733 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,05012904 0,0828877 ! regulation of exocytosis GO:0017157 17 13 0,000 0,05012904 0,08282815 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,05012904 0,08276869 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,05012904 0,08270932 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,05012904 0,08265003 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,05012904 0,08259082 ! genitalia development GO:0048806 15 13 0,000 0,05012904 0,0825317 ! cellular pigmentation GO:0033059 24 13 0,000 0,05012904 0,08247267 ! tissue regeneration GO:0042246 21 13 0,000 0,05012904 0,08241371 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,05012904 0,08235485 ! cofactor transport GO:0051181 19 13 0,000 0,05012904 0,08229606 ! NADP metabolic process GO:0006739 18 13 0,000 0,05012904 0,08223736 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,05012904 0,08217875 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,05012904 0,08212022 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05012904 0,08206177 ! gas transport GO:0015669 18 13 0,000 0,05012904 0,0820034 ! regulation of RNA stability GO:0043487 28 13 0,000 0,05012904 0,08194512 ! heme biosynthetic process GO:0006783 20 13 0,000 0,05012904 0,08188692 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,05012904 0,0818288 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,05012904 0,08177077 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,05012904 0,08171282 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,05012904 0,08165495 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,05012904 0,08159716 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,05012904 0,08153945 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,05119875 0,08322058 ! cell fate commitment GO:0045165 141 92 1,000 0,05119875 0,08316181 ! response to oxidative stress GO:0006979 141 94 1,000 0,05319569 0,08634445 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05388089 0,08739495 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,05388089 0,08733336 ! superoxide anion generation GO:0042554 18 14 0,000 0,05388089 0,08727186 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,05388089 0,08721045 ! myotube differentiation GO:0014902 21 14 0,000 0,05388089 0,08714912 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,05388089 0,08708787 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,05388089 0,08702672 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05388089 0,08696565 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05388089 0,08690466 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05388089 0,08684376 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05388089 0,08678294 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05388089 0,08672221 ! response to cAMP GO:0051591 19 14 0,000 0,05388089 0,08666157 ! limbic system development GO:0021761 25 14 0,000 0,05388089 0,08660101 ! startle response GO:0001964 21 14 0,000 0,05388089 0,08654053 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,05388089 0,08648014 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05388089 0,08641984 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05388089 0,08635961 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,05388089 0,08629947 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05388089 0,08623942 ! glycine metabolic process GO:0006544 22 14 0,000 0,05388089 0,08617945 ! pituitary gland development GO:0021983 23 14 0,000 0,05388089 0,08611956 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,05388089 0,08605975 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,05388089 0,08600003 ! regulation of heart rate GO:0002027 23 14 0,000 0,05388089 0,08594039 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05388089 0,08588083 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,05388089 0,08582136 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05388089 0,08576197 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05388089 0,08570266 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,05388089 0,08564343 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,05388089 0,08558428 ! axon cargo transport GO:0008088 27 14 0,000 0,05388089 0,08552522 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05388089 0,08546624 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05388089 0,08540734 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05388089 0,08534852 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05388089 0,08528978 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05388089 0,08523112 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05388089 0,08517254 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05388089 0,08511404 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05388089 0,08505562 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05388089 0,08499729 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05388089 0,08493903 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05388089 0,08488085 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,05388089 0,08482275 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,05388089 0,08476474 ! muscle maintenance GO:0046716 19 14 0,000 0,05388089 0,0847068 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05388089 0,08464894 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05388089 0,08459116 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,05388089 0,08453345 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05388089 0,08447583 ! cell killing GO:0001906 20 14 0,000 0,05388089 0,08441829 ! cilium assembly GO:0042384 20 14 0,000 0,05388089 0,08436082 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05388089 0,08430343 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,05522011 0,08634008 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,05624246 0,08787885 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,05761814 0,08996722 ! positive regulation of cell size GO:0045793 20 15 0,000 0,05761814 0,08990618 ! metencephalon development GO:0022037 19 15 0,000 0,05761814 0,08984523 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,05761814 0,08978436 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,05761814 0,08972357 ! skin development GO:0043588 25 15 0,000 0,05761814 0,08966286 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,05761814 0,08960224 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,05761814 0,0895417 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,05761814 0,08948124 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,05761814 0,08942086 ! bile acid metabolic process GO:0008206 22 15 0,000 0,05761814 0,08936056 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,05761814 0,08930034 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,05761814 0,08924021 ! adult walking behavior GO:0007628 25 15 0,000 0,05761814 0,08918016 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,05761814 0,08912018 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,05761814 0,08906029 ! myoblast differentiation GO:0045445 27 15 0,000 0,05761814 0,08900048 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,05761814 0,08894075 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,05761814 0,08888109 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,05761814 0,08882152 ! response to osmotic stress GO:0006970 22 15 0,000 0,05761814 0,08876203 ! vesicle coating GO:0006901 25 15 0,000 0,05761814 0,08870262 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,05761814 0,08864328 ! DNA integration GO:0015074 22 15 0,000 0,05761814 0,08858403 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,05761814 0,08852486 ! peptide secretion GO:0002790 27 15 0,000 0,05761814 0,08846576 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,05761814 0,08840675 ! regulation of vasodilation GO:0042312 24 15 0,000 0,05761814 0,08834781 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,05761814 0,08828895 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,05761814 0,08823017 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,05761814 0,08817146 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,05761814 0,08811284 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,05761814 0,08805429 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,05761814 0,08799582 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,05761814 0,08793743 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,05761814 0,08787912 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,05761814 0,08782088 ! dopamine metabolic process GO:0042417 30 15 0,000 0,05761814 0,08776272 ! organic cation transport GO:0015695 19 15 0,000 0,05761814 0,08770464 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,05761814 0,08764663 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,05761814 0,08758871 ! defense response to virus GO:0051607 27 15 0,000 0,05761814 0,08753085 ! peptide hormone processing GO:0016486 19 15 0,000 0,05761814 0,08747308 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,05761814 0,08741538 ! protein import GO:0017038 156 99 1,000 0,0583071 0,08840233 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,0583071 0,0883441 ! regulation of translation GO:0006417 151 100 1,000 0,05934926 0,08986392 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,05934926 0,0898048 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,05934926 0,08974576 ! protein localization in organelle GO:0033365 161 100 1,000 0,05934926 0,08968679 ! protein secretion GO:0009306 27 16 0,000 0,06134083 0,09263553 ! hormone secretion GO:0046879 25 16 0,000 0,06134083 0,09257475 ! bone remodeling GO:0046849 24 16 0,000 0,06134083 0,09251404 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,06134083 0,09245342 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06134083 0,09239287 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,06134083 0,0923324 ! glial cell development GO:0021782 24 16 0,000 0,06134083 0,09227202 ! patterning of blood vessels GO:0001569 24 16 0,000 0,06134083 0,09221171 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,06134083 0,09215148 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,06134083 0,09209133 ! protein polyubiquitination GO:0000209 26 16 0,000 0,06134083 0,09203126 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,06134083 0,09197126 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,06134083 0,09191134 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,06134083 0,09185151 ! fructose metabolic process GO:0006000 20 16 0,000 0,06134083 0,09179175 ! regulation of protein binding GO:0043393 27 16 0,000 0,06134083 0,09173206 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,06134083 0,09167246 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,06134083 0,09161293 ! protein export from nucleus GO:0006611 24 16 0,000 0,06134083 0,09155348 ! negative regulation of immune response GO:0050777 28 16 0,000 0,06134083 0,09149411 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,06134083 0,09143481 ! DNA replication initiation GO:0006270 25 16 0,000 0,06134083 0,09137559 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,06134083 0,09131645 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,06134083 0,09125738 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,06134083 0,09119839 ! diencephalon development GO:0021536 25 16 0,000 0,06134083 0,09113948 ! neural crest cell migration GO:0001755 24 16 0,000 0,06134083 0,09108064 ! G1 phase GO:0051318 27 16 0,000 0,06134083 0,09102188 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,06134083 0,09096319 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,06134083 0,09090458 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,06134083 0,09084605 ! steroid catabolic process GO:0006706 22 16 0,000 0,06134083 0,09078759 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,06134083 0,09072921 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,06134083 0,0906709 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,06134083 0,09061266 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,06134083 0,0905545 ! sperm-egg recognition GO:0035036 16 16 0,000 0,06134083 0,09049642 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,06134083 0,09043841 ! nerve development GO:0021675 18 16 0,000 0,06134083 0,09038047 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,06134083 0,09032261 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,06134083 0,09026482 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06504904 0,09566035 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06504904 0,09559922 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06504904 0,09553818 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06504904 0,09547721 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06504904 0,09541632 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06504904 0,0953555 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06504904 0,09529477 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06504904 0,09523411 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06504904 0,09517353 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,06504904 0,09511302 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06504904 0,09505259 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06504904 0,09499224 ! memory GO:0007613 25 17 0,000 0,06504904 0,09493197 ! keratinization GO:0031424 17 17 0,000 0,06504904 0,09487177 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,06504904 0,09481165 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,06504904 0,0947516 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06504904 0,09469163 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,06504904 0,09463174 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,06504904 0,09457192 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06504904 0,09451218 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06504904 0,09445251 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,06504904 0,09439292 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,06504904 0,09433341 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06504904 0,09427396 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06504904 0,0942146 ! membrane budding GO:0006900 29 17 0,000 0,06504904 0,09415531 ! heme metabolic process GO:0042168 27 17 0,000 0,06504904 0,09409609 ! actin filament bundle formation GO:0051017 26 17 0,000 0,06504904 0,09403695 ! body fluid secretion GO:0007589 27 17 0,000 0,06504904 0,09397788 ! stem cell differentiation GO:0048863 36 17 0,000 0,06504904 0,09391888 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,06504904 0,09385996 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06504904 0,09380112 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06504904 0,09374234 ! sensory perception of pain GO:0019233 23 17 0,000 0,06504904 0,09368365 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06504904 0,09362502 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06504904 0,09356647 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,06504904 0,09350799 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06504904 0,09344958 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06504904 0,09339125 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06504904 0,09333299 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06504904 0,0932748 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06504904 0,09321669 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,06504904 0,09315864 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06504904 0,09310067 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06504904 0,09304278 ! positive regulation of translation GO:0045727 28 18 0,000 0,0687428 0,09826504 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,0687428 0,098204 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,0687428 0,09814304 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,0687428 0,09808216 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,0687428 0,09802135 ! cAMP metabolic process GO:0046058 33 18 0,000 0,0687428 0,09796062 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,0687428 0,09789996 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,0687428 0,09783938 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,0687428 0,09777888 ! axis specification GO:0009798 26 18 0,000 0,0687428 0,09771844 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,0687428 0,09765809 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,0687428 0,0975978 ! pancreas development GO:0031016 26 18 0,000 0,0687428 0,0975376 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,0687428 0,09747746 ! glutamine metabolic process GO:0006541 23 18 0,000 0,0687428 0,0974174 ! response to retinoic acid GO:0032526 25 18 0,000 0,0687428 0,09735742 ! pigmentation during development GO:0048066 31 18 0,000 0,0687428 0,0972975 ! central nervous system neuron development GO:0021954 30 18 0,000 0,0687428 0,09723766 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,0687428 0,0971779 ! fucose metabolic process GO:0006004 26 18 0,000 0,0687428 0,09711821 ! response to fungus GO:0009620 19 18 0,000 0,0687428 0,09705859 ! peptide cross-linking GO:0018149 31 18 0,000 0,0687428 0,09699904 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,0687428 0,09693957 ! heart process GO:0003015 27 18 0,000 0,0687428 0,09688017 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,0687428 0,09682085 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,0687428 0,09676159 ! visual learning GO:0008542 35 18 0,000 0,0687428 0,09670241 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,0687428 0,0966433 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,0687428 0,09658427 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,0687428 0,0965253 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,0687428 0,09646641 ! vitamin transport GO:0051180 24 18 0,000 0,0687428 0,09640759 ! hormone transport GO:0009914 27 18 0,000 0,0687428 0,09634884 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,0687428 0,09629016 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,0687428 0,09623155 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,0687428 0,09617302 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,0687428 0,09611456 ! cell-cell recognition GO:0009988 20 18 0,000 0,0687428 0,09605616 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,0687428 0,09599784 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,0687428 0,09593959 ! regulation of glucose import GO:0046324 21 18 0,000 0,0687428 0,09588141 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,0687428 0,0958233 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,0687428 0,09576526 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,07242218 0,10082992 ! positive regulation of ossification GO:0045778 30 19 0,000 0,07242218 0,10076892 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,07242218 0,100708 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,07242218 0,10064714 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,07242218 0,10058637 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,07242218 0,10052566 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,07242218 0,10046503 ! regeneration GO:0031099 32 19 0,000 0,07242218 0,10040448 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,07242218 0,10034399 ! response to alkaloid GO:0043279 32 19 0,000 0,07242218 0,10028358 ! sensory perception of taste GO:0050909 23 19 0,000 0,07242218 0,10022324 ! smooth muscle contraction GO:0006939 36 19 0,000 0,07242218 0,10016297 ! peroxisome organization GO:0007031 29 19 0,000 0,07242218 0,10010278 ! digestive system process GO:0022600 30 19 0,000 0,07242218 0,10004266 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,07242218 0,09998261 ! response to vitamin A GO:0033189 26 19 0,000 0,07242218 0,09992263 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,07242218 0,09986272 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,07242218 0,09980289 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,07242218 0,09974313 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,07242218 0,09968344 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,07242218 0,09962382 ! plasma membrane fusion GO:0045026 23 19 0,000 0,07242218 0,09956427 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,07242218 0,09950479 ! cytolysis GO:0019835 20 19 0,000 0,07242218 0,09944539 ! renal system process GO:0003014 35 19 0,000 0,07242218 0,09938605 ! vasodilation GO:0042311 33 19 0,000 0,07242218 0,09932679 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,07242218 0,09926759 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,07242218 0,09920847 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,07242218 0,09914942 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,07242218 0,09909044 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,07242218 0,09903152 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,07242218 0,09897268 ! sarcomere organization GO:0045214 23 19 0,000 0,07242218 0,09891391 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,07242218 0,09885521 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,07242218 0,09879657 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,07242218 0,09873801 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,07242218 0,09867952 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,07242218 0,09862109 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,07242218 0,09856274 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,07242218 0,09850445 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,07242218 0,09844623 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,07608724 0,10336719 ! iron ion transport GO:0006826 37 20 0,000 0,07608724 0,10330617 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,07608724 0,10324522 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,07608724 0,10318435 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,07608724 0,10312354 ! response to vitamin GO:0033273 29 20 0,000 0,07608724 0,10306281 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,07608724 0,10300215 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,07608724 0,10294156 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,07608724 0,10288104 ! spinal cord development GO:0021510 31 20 0,000 0,07608724 0,10282059 ! response to ethanol GO:0045471 37 20 0,000 0,07608724 0,10276022 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,07608724 0,10269991 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,07608724 0,10263968 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,07608724 0,10257952 ! chromosome condensation GO:0030261 31 20 0,000 0,07608724 0,10251942 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,07608724 0,1024594 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,07608724 0,10239945 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,07608724 0,10233956 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,07608724 0,10227975 ! DNA modification GO:0006304 28 20 0,000 0,07608724 0,10222001 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,07608724 0,10216033 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,07608724 0,10210073 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,07608724 0,1020412 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,07608724 0,10198173 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,07608724 0,10192234 ! collagen catabolic process GO:0030574 25 20 0,000 0,07608724 0,10186301 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,07608724 0,10180375 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,07608724 0,10174457 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,07608724 0,10168545 ! alditol metabolic process GO:0019400 24 20 0,000 0,07608724 0,1016264 ! actin filament-based movement GO:0030048 34 20 0,000 0,07608724 0,10156741 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,07973802 0,10637903 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,07973802 0,10631736 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,07973802 0,10625577 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,07973802 0,10619424 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,07973802 0,10613279 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,07973802 0,1060714 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,07973802 0,10601009 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,07973802 0,10594885 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,07973802 0,10588768 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,07973802 0,10582658 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,07973802 0,10576554 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,07973802 0,10570458 ! vesicle docking GO:0048278 27 21 0,000 0,07973802 0,1056437 ! phototransduction GO:0007602 25 21 0,000 0,07973802 0,10558288 ! dendrite development GO:0016358 35 21 0,000 0,07973802 0,10552213 ! visual behavior GO:0007632 39 21 0,000 0,07973802 0,10546145 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,07973802 0,10540084 ! ovarian follicle development GO:0001541 30 21 0,000 0,07973802 0,1053403 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,07973802 0,10527982 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,07973802 0,10521942 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,07973802 0,10515909 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,07973802 0,10509883 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,07973802 0,10503863 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,07973802 0,10497851 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,07973802 0,10491845 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,07973802 0,10485846 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,07973802 0,10479855 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,07973802 0,10473869 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,07973802 0,10467891 ! fatty acid transport GO:0015908 30 21 0,000 0,07973802 0,1046192 ! immunoglobulin production GO:0002377 33 21 0,000 0,07973802 0,10455955 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,07973802 0,10449997 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,07973802 0,10444046 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,07973802 0,10438102 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,07973802 0,10432165 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,07973802 0,10426234 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,07973802 0,1042031 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,07973802 0,10414393 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,07973802 0,10408482 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,07973802 0,10402578 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,07973802 0,10396681 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,07973802 0,10390791 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,07973802 0,10384907 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,07973802 0,1037903 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,07973802 0,10373159 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,08337459 0,10840111 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,08337459 0,10833986 ! viral genome replication GO:0019079 29 22 0,000 0,08337459 0,10827869 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,08337459 0,10821758 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,08337459 0,10815655 ! leukocyte adhesion GO:0007159 38 22 0,000 0,08337459 0,10809558 ! molting cycle process GO:0022404 40 22 0,000 0,08337459 0,10803468 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,08337459 0,10797385 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,08337459 0,10791309 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,08337459 0,10785239 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,08337459 0,10779177 ! vasculogenesis GO:0001570 33 22 0,000 0,08337459 0,10773121 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,08337459 0,10767072 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,08337459 0,1076103 ! lysosome organization GO:0007040 37 22 0,000 0,08337459 0,10754995 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,08337459 0,10748966 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,08337459 0,10742944 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,08337459 0,10736929 ! regulation of behavior GO:0050795 38 22 0,000 0,08337459 0,10730921 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,08337459 0,10724919 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,08337459 0,10718924 ! membrane depolarization GO:0051899 35 22 0,000 0,08337459 0,10712936 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,08337459 0,10706955 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,08337459 0,1070098 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,08337459 0,10695011 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,08337459 0,1068905 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,08337459 0,10683095 ! neural tube closure GO:0001843 33 22 0,000 0,08337459 0,10677147 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,08337459 0,10671205 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,08699699 0,11128648 ! neuron fate commitment GO:0048663 32 23 0,000 0,08699699 0,11122462 ! embryonic pattern specification GO:0009880 31 23 0,000 0,08699699 0,11116282 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,08699699 0,1111011 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,08699699 0,11103945 ! vesicle targeting GO:0006903 32 23 0,000 0,08699699 0,11097786 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,08699699 0,11091634 ! osteoblast differentiation GO:0001649 40 23 0,000 0,08699699 0,11085489 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,08699699 0,11079351 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,08699699 0,1107322 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,08699699 0,11067095 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,08699699 0,11060977 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,08699699 0,11054866 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,08699699 0,11048762 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,08699699 0,11042665 ! cell fate determination GO:0001709 45 23 0,000 0,08699699 0,11036574 ! pentose metabolic process GO:0019321 31 23 0,000 0,08699699 0,1103049 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,08699699 0,11024412 ! spermatid development GO:0007286 33 23 0,000 0,08699699 0,11018342 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,08699699 0,11012278 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,08699699 0,1100622 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,08699699 0,11000169 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,08699699 0,10994125 ! telomere organization GO:0032200 32 23 0,000 0,08699699 0,10988088 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,08699699 0,10982057 ! regulation of amine transport GO:0051952 38 23 0,000 0,08699699 0,10976033 ! liver development GO:0001889 40 23 0,000 0,08699699 0,10970015 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,09060529 0,11418748 ! initiation of viral infection GO:0019059 42 24 0,000 0,09060529 0,11412495 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,09060529 0,11406248 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,09060529 0,11400009 ! superoxide metabolic process GO:0006801 32 24 0,000 0,09060529 0,11393776 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,09060529 0,1138755 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,09060529 0,1138133 ! fat cell differentiation GO:0045444 37 24 0,000 0,09060529 0,11375118 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,09060529 0,11368912 ! sperm motility GO:0030317 27 24 0,000 0,09060529 0,11362713 ! vacuole organization GO:0007033 39 24 0,000 0,09060529 0,11356521 ! neural crest cell development GO:0014032 39 24 0,000 0,09060529 0,11350335 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,09060529 0,11344157 ! primary neural tube formation GO:0014020 35 24 0,000 0,09060529 0,11337985 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,09060529 0,11331819 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,09060529 0,11325661 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,09060529 0,11319509 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,09060529 0,11313364 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,09060529 0,11307225 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,09060529 0,11301093 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,09419953 0,1174303 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,09419953 0,11736669 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,09419953 0,11730315 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,09419953 0,11723967 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,09419953 0,11717626 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,09419953 0,11711292 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,09419953 0,11704965 ! peptide transport GO:0015833 43 25 0,000 0,09419953 0,11698645 ! male gonad development GO:0008584 33 25 0,000 0,09419953 0,11692332 ! iron ion homeostasis GO:0055072 39 25 0,000 0,09419953 0,11686025 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,09419953 0,11679726 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,09419953 0,11673433 ! phospholipid transport GO:0015914 35 25 0,000 0,09419953 0,11667146 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,09419953 0,11660867 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,09419953 0,11654594 ! detection of light stimulus GO:0009583 30 25 0,000 0,09419953 0,11648329 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,09419953 0,11642069 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,09419953 0,11635817 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,09777977 0,12071576 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,09777977 0,120651 ! translational initiation GO:0006413 43 26 0,000 0,09777977 0,12058631 ! circadian rhythm GO:0007623 42 26 0,000 0,09777977 0,12052168 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,09777977 0,12045713 ! post-embryonic development GO:0009791 42 26 0,000 0,09777977 0,12039264 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,09777977 0,12032823 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,09777977 0,12026388 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,09777977 0,1201996 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,09777977 0,1201354 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,09777977 0,12007125 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,09777977 0,12000718 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,09777977 0,11994318 ! regulation of coagulation GO:0050818 39 26 0,000 0,09777977 0,11987924 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,10134606 0,12418537 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,10134606 0,12411924 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,10134606 0,12405318 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,10134606 0,1239872 ! membrane docking GO:0022406 39 27 0,000 0,10134606 0,12392128 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,10134606 0,12385544 ! catechol metabolic process GO:0009712 43 27 0,000 0,10134606 0,12378966 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,10134606 0,12372396 ! acute-phase response GO:0006953 42 27 0,000 0,10134606 0,12365832 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,10134606 0,12359275 ! myofibril assembly GO:0030239 36 27 0,000 0,10134606 0,12352726 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,10134606 0,12346183 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,10134606 0,12339647 ! natural killer cell activation GO:0030101 35 27 0,000 0,10134606 0,12333118 ! lipid oxidation GO:0034440 38 27 0,000 0,10134606 0,12326596 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,10134606 0,12320081 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,10134606 0,12313573 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,10134606 0,12307071 ! gene silencing GO:0016458 41 27 0,000 0,10134606 0,12300577 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,10489846 0,12725024 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,10489846 0,12718316 ! phenol metabolic process GO:0018958 44 28 0,000 0,10489846 0,12711615 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,10489846 0,12704921 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,10489846 0,12698234 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,10489846 0,12691554 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,10489846 0,12684882 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,10489846 0,12678216 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,10489846 0,12671557 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,10489846 0,12664905 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,10489846 0,12658261 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,10489846 0,12651623 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,10489846 0,12644992 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,10489846 0,12638368 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,10489846 0,12631751 ! mesoderm formation GO:0001707 46 28 0,000 0,10489846 0,12625141 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,10489846 0,12618538 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,10489846 0,12611942 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,10489846 0,12605353 ! BMP signaling pathway GO:0030509 40 28 0,000 0,10489846 0,1259877 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,10489846 0,12592195 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,10489846 0,12585626 ! neural tube formation GO:0001841 41 28 0,000 0,10489846 0,12579064 ! placenta development GO:0001890 37 28 0,000 0,10489846 0,12572509 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,10843702 0,12989851 ! regulation of innate immune response GO:0045088 38 29 0,000 0,10843702 0,12983089 ! ovulation cycle process GO:0022602 41 29 0,000 0,10843702 0,12976334 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,10843702 0,12969586 ! protein targeting to membrane GO:0006612 53 29 0,000 0,10843702 0,12962845 ! mismatch repair GO:0006298 34 29 0,000 0,10843702 0,12956111 ! muscle cell development GO:0055001 38 29 0,000 0,10843702 0,12949384 ! formation of primary germ layer GO:0001704 48 29 0,000 0,10843702 0,12942664 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,10843702 0,12935951 ! eye morphogenesis GO:0048592 51 29 0,000 0,10843702 0,12929245 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,10843702 0,12922546 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,11196179 0,13335687 ! collagen metabolic process GO:0032963 40 30 0,000 0,11196179 0,13328784 ! organic anion transport GO:0015711 51 30 0,000 0,11196179 0,13321889 ! cholesterol transport GO:0030301 46 30 0,000 0,11196179 0,13315001 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,11196179 0,13308119 ! spliceosome assembly GO:0000245 49 30 0,000 0,11196179 0,13301245 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,11196179 0,13294378 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,11196179 0,13287519 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,11196179 0,13280666 ! ceramide metabolic process GO:0006672 43 30 0,000 0,11196179 0,1327382 ! ovulation cycle GO:0042698 43 30 0,000 0,11196179 0,13266981 ! hindbrain development GO:0030902 45 30 0,000 0,11196179 0,1326015 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,11196179 0,13253325 ! adult locomotory behavior GO:0008344 47 30 0,000 0,11196179 0,13246508 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,11196179 0,13239697 ! response to heat GO:0009408 41 30 0,000 0,11196179 0,13232894 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,11196179 0,13226097 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,11196179 0,13219308 ! glial cell differentiation GO:0010001 55 31 0,000 0,11547283 0,1362686 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,11547283 0,13619872 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,11547283 0,13612891 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,11547283 0,13605917 ! odontogenesis GO:0042476 50 31 0,000 0,11547283 0,1359895 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,11547283 0,13591991 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,11547283 0,13585038 ! metanephros development GO:0001656 58 31 0,000 0,11547283 0,13578093 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,11547283 0,13571155 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,11547283 0,13564224 ! cell fate specification GO:0001708 37 31 0,000 0,11547283 0,135573 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,11547283 0,13550383 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,11547283 0,13543473 ! RNA modification GO:0009451 40 31 0,000 0,11547283 0,1353657 ! regulation of muscle development GO:0048634 48 32 0,000 0,11897018 0,13939451 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,11897018 0,13932353 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,11897018 0,13925263 ! meiosis I GO:0007127 52 32 0,000 0,11897018 0,1391818 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,11897018 0,13911104 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,11897018 0,13904036 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,11897018 0,13896974 ! cytokine production GO:0001816 44 32 0,000 0,11897018 0,1388992 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,11897018 0,13882873 ! vesicle localization GO:0051648 47 32 0,000 0,11897018 0,13875833 ! RNA export from nucleus GO:0006405 44 33 0,000 0,12245391 0,14274911 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,12245391 0,1426768 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,12245391 0,14260455 ! sister chromatid segregation GO:0000819 46 33 0,000 0,12245391 0,14253239 ! ear morphogenesis GO:0042471 42 33 0,000 0,12245391 0,14246029 ! actomyosin structure organization GO:0031032 43 33 0,000 0,12245391 0,14238827 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,12245391 0,14231632 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,12245391 0,14224444 ! nucleus organization GO:0006997 49 33 0,000 0,12245391 0,14217264 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,12245391 0,1421009 ! positive regulation of cell development GO:0010720 54 33 0,000 0,12245391 0,14202925 ! lipid homeostasis GO:0055088 55 33 0,000 0,12245391 0,14195766 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,12245391 0,14188614 ! regulation of proteolysis GO:0030162 50 33 0,000 0,12245391 0,1418147 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,12245391 0,14174333 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,12245391 0,14167203 ! mRNA catabolic process GO:0006402 48 34 0,000 0,12592406 0,14561355 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,12592406 0,14554037 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,12592406 0,14546727 ! feeding behavior GO:0007631 45 34 0,000 0,12592406 0,14539425 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,12592406 0,1453213 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,12592406 0,14524842 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,12592406 0,14517561 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,12592406 0,14510288 ! aerobic respiration GO:0009060 47 34 0,000 0,12592406 0,14503022 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,12592406 0,14495763 ! embryonic organ development GO:0048568 45 34 0,000 0,12592406 0,14488511 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,12938069 0,14878779 ! Notch signaling pathway GO:0007219 56 35 0,000 0,12938069 0,14871344 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,12938069 0,14863915 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,12938069 0,14856495 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,12938069 0,14849081 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,12938069 0,14841675 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,12938069 0,14834277 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,12938069 0,14826885 ! glycogen metabolic process GO:0005977 48 35 0,000 0,12938069 0,14819501 ! pigment metabolic process GO:0042440 61 35 0,000 0,12938069 0,14812125 ! protein homooligomerization GO:0051260 52 35 0,000 0,12938069 0,14804756 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,13282385 0,15191191 ! tissue remodeling GO:0048771 62 36 0,000 0,13282385 0,1518364 ! neural tube development GO:0021915 50 36 0,000 0,13282385 0,15176098 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,13282385 0,15168562 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,13282385 0,15161034 ! glucan metabolic process GO:0044042 49 36 0,000 0,13282385 0,15153514 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,13625358 0,15537096 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,13625358 0,15529397 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,13625358 0,15521706 ! ion transmembrane transport GO:0034220 56 37 0,000 0,13625358 0,15514022 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,13625358 0,15506345 ! regulation of protein secretion GO:0050708 51 37 0,000 0,13625358 0,15498676 ! amino acid activation GO:0043038 52 37 0,000 0,13625358 0,15491015 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,13625358 0,15483361 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,13966995 0,15863747 ! gliogenesis GO:0042063 71 38 0,000 0,13966995 0,15855917 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,13966995 0,15848095 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,13966995 0,1584028 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,13966995 0,15832473 ! phagocytosis GO:0006909 60 38 0,000 0,13966995 0,15824674 ! pigmentation GO:0043473 74 38 0,000 0,13966995 0,15816882 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,14307299 0,16194286 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,14307299 0,1618632 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,14307299 0,16178362 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,14307299 0,16170412 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,14307299 0,1616247 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,14307299 0,16154535 ! male sex differentiation GO:0046661 53 39 0,000 0,14307299 0,16146609 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,14307299 0,1613869 ! chromatin remodeling GO:0006338 68 39 0,000 0,14307299 0,16130779 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,14307299 0,16122875 ! JNK cascade GO:0007254 54 39 0,000 0,14307299 0,1611498 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,14646278 0,16488712 ! response to calcium ion GO:0051592 58 40 0,000 0,14646278 0,16480645 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,14646278 0,16472586 ! regulation of tube size GO:0035150 60 40 0,000 0,14646278 0,16464535 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,14646278 0,16456492 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,14646278 0,16448456 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,14646278 0,16440429 ! peptide metabolic process GO:0006518 56 40 0,000 0,14646278 0,16432409 ! inner ear development GO:0048839 57 40 0,000 0,14646278 0,16424397 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,14646278 0,16416393 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,14646278 0,16408397 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,14646278 0,16400408 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,14646278 0,16392427 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,14983934 0,16762183 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,14983934 0,16754034 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,14983934 0,16745893 ! glucose transport GO:0015758 52 41 0,000 0,14983934 0,1673776 ! striated muscle contraction GO:0006941 62 41 0,000 0,14983934 0,16729635 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,14983934 0,16721518 ! biopolymer methylation GO:0043414 62 41 0,000 0,14983934 0,16713409 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,14983934 0,16705307 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,15320274 0,17072011 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,15320274 0,17063744 ! cellular component disassembly GO:0022411 64 42 0,000 0,15320274 0,17055485 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,15320274 0,17047233 ! hexose transport GO:0008645 54 42 0,000 0,15320274 0,1703899 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,15320274 0,17030755 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,15320274 0,17022527 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,15320274 0,17014308 ! excretion GO:0007588 63 42 0,000 0,15320274 0,17006096 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,15320274 0,16997892 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,15320274 0,16989697 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,15320274 0,16981509 ! regulation of cell shape GO:0008360 78 42 0,000 0,15320274 0,16973329 ! leukocyte migration GO:0050900 60 43 0,000 0,15655303 0,17336157 ! neuromuscular process GO:0050905 79 43 0,000 0,15655303 0,17327814 ! tRNA processing GO:0008033 49 43 0,000 0,15655303 0,17319479 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,15655303 0,17311152 ! vesicle organization GO:0016050 79 43 0,000 0,15655303 0,17302834 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,15655303 0,17294523 ! methylation GO:0032259 64 43 0,000 0,15655303 0,1728622 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,15989025 0,17646237 ! glycolysis GO:0006096 53 44 0,000 0,15989025 0,17637774 ! regulation of ion transport GO:0043269 57 44 0,000 0,15989025 0,17629319 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,15989025 0,17620871 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,15989025 0,17612432 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,15989025 0,17604001 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,15989025 0,17595578 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,15989025 0,17587163 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,15989025 0,17578756 ! RNA catabolic process GO:0006401 64 45 0,000 0,16321446 0,17935655 ! positive regulation of defense response GO:0031349 59 45 0,000 0,16321446 0,1792709 ! regulation of translational initiation GO:0006446 64 45 0,000 0,16321446 0,17918533 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,16321446 0,17909984 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,16321446 0,17901443 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,16652571 0,18255917 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,16652571 0,18247219 ! cell redox homeostasis GO:0045454 63 46 0,000 0,16652571 0,1823853 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,16652571 0,18229849 ! regulation of ossification GO:0030278 71 46 0,000 0,16652571 0,18221177 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,16652571 0,18212512 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,16982404 0,18564415 ! viral infectious cycle GO:0019058 71 47 0,000 0,16982404 0,18555596 ! endocrine system development GO:0035270 83 47 0,000 0,16982404 0,18546785 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,16982404 0,18537983 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,16982404 0,18529189 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,16982404 0,18520403 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,16982404 0,18511626 ! chloride transport GO:0006821 67 48 0,000 0,17310951 0,18860818 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,17310951 0,18851888 ! response to temperature stimulus GO:0009266 62 48 0,000 0,17310951 0,18842966 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,17310951 0,18834053 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,17310951 0,18825148 ! gastrulation GO:0007369 73 48 0,000 0,17310951 0,18816251 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,17310951 0,18807363 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,17310951 0,18798483 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,17310951 0,18789612 ! regulation of endocytosis GO:0030100 63 48 0,000 0,17310951 0,18780749 ! nuclear export GO:0051168 69 48 0,000 0,17310951 0,18771894 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,17310951 0,18763048 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,17638217 0,1910876 ! sensory perception of smell GO:0007608 61 49 0,000 0,17638217 0,19099764 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,17638217 0,19090776 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,17638217 0,19081796 ! RNA elongation GO:0006354 62 49 0,000 0,17638217 0,19072825 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,17638217 0,19063862 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,17638217 0,19054907 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,17638217 0,19045962 ! cartilage development GO:0051216 70 49 0,000 0,17638217 0,19037024 ! regulation of actin filament length GO:0030832 72 50 0,000 0,17964205 0,19379771 ! ear development GO:0043583 72 50 0,000 0,17964205 0,19370686 ! membrane fusion GO:0006944 80 50 0,000 0,17964205 0,19361608 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,17964205 0,1935254 ! proton transport GO:0015992 75 50 0,000 0,17964205 0,1934348 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,17964205 0,19334428 ! hydrogen transport GO:0006818 77 51 0,000 0,18288923 0,19674706 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,18288923 0,19665508 ! adult behavior GO:0030534 80 51 0,000 0,18288923 0,19656319 ! transition metal ion transport GO:0000041 74 52 0,000 0,18612373 0,19994609 ! regulation of cellular component size GO:0032535 74 52 0,000 0,18612373 0,19985274 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,18612373 0,19975949 ! establishment of organelle localization GO:0051656 85 52 0,000 0,18612373 0,19966631 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,18934561 0,20302793 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,18934561 0,20293332 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,18934561 0,20283881 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,18934561 0,20274437 ! kidney development GO:0001822 90 53 0,000 0,18934561 0,20265003 ! single fertilization GO:0007338 59 53 0,000 0,18934561 0,20255577 ! cell projection assembly GO:0030031 76 53 0,000 0,18934561 0,20246161 ! amino acid transport GO:0006865 84 54 0,000 0,19255493 0,20579756 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,19255493 0,20570197 ! regulation of mitosis GO:0007088 84 54 0,000 0,19255493 0,20560647 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,19255493 0,20551106 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,19255493 0,20541574 ! DNA catabolic process GO:0006308 67 54 0,000 0,19255493 0,20532051 ! detection of external stimulus GO:0009581 66 54 0,000 0,19255493 0,20522537 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,19255493 0,20513031 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,19255493 0,20503534 ! exocytosis GO:0006887 74 55 0,000 0,19575172 0,20834288 ! mesoderm development GO:0007498 76 55 0,000 0,19575172 0,20824651 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,19575172 0,20815024 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,19575172 0,20805405 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,19893604 0,21134083 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,19893604 0,21124326 ! carbohydrate transport GO:0008643 74 57 0,000 0,20210794 0,21451235 ! chromosome segregation GO:0007059 83 57 0,000 0,20210794 0,2144134 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,20210794 0,21431455 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,20210794 0,21421578 ! camera-type eye development GO:0043010 88 57 0,000 0,20210794 0,21411711 ! secondary metabolic process GO:0019748 84 57 0,000 0,20210794 0,21401853 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,20526745 0,21726421 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,20526745 0,21716428 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,20841464 0,22039249 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,20841464 0,2202912 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,20841464 0,22019001 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,21154954 0,22339942 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,21154954 0,2232969 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,21154954 0,22319447 ! regulation of heart contraction GO:0008016 91 60 0,000 0,21154954 0,22309213 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,21154954 0,22298989 ! fertilization GO:0009566 68 60 0,000 0,21154954 0,22288774 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,21154954 0,22278568 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,2146722 0,22597074 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,2146722 0,22586737 ! urogenital system development GO:0001655 101 61 0,000 0,2146722 0,22576409 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,2146722 0,22566091 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,2146722 0,22555782 ! extracellular matrix organization GO:0030198 103 61 0,000 0,2146722 0,22545482 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,2146722 0,22535192 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,2146722 0,22524912 ! amine catabolic process GO:0009310 90 62 0,000 0,21778268 0,22840865 ! neurotransmitter transport GO:0006836 81 62 0,000 0,21778268 0,22830454 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,21778268 0,22820053 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,21778268 0,22809661 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,21778268 0,22799279 ! appendage morphogenesis GO:0035107 93 64 0,000 0,22396725 0,23436064 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,22396725 0,23425406 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,22396725 0,23414758 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,22396725 0,2340412 ! hexose catabolic process GO:0019320 82 64 0,000 0,22396725 0,23393492 ! adaptive immune response GO:0002250 94 64 0,000 0,22396725 0,23382873 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,22704145 0,23693073 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,22704145 0,23682328 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,22704145 0,23671592 ! defense response to bacterium GO:0042742 73 65 0,000 0,22704145 0,23660867 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,22704145 0,23650151 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,22704145 0,23639444 ! activation of immune response GO:0002253 83 65 0,000 0,22704145 0,23628748 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,23010363 0,23936606 ! antigen processing and presentation GO:0019882 96 66 0,000 0,23010363 0,23925785 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,23010363 0,23914973 ! regulation of immune effector process GO:0002697 101 66 0,000 0,23010363 0,23904172 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,23315387 0,24210108 ! acute inflammatory response GO:0002526 92 68 0,000 0,23619219 0,24514532 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,23619219 0,24503475 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,23619219 0,24492427 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,23619219 0,2448139 ! rhythmic process GO:0048511 105 68 0,000 0,23619219 0,24470362 ! inorganic anion transport GO:0015698 93 68 0,000 0,23619219 0,24459344 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,23921865 0,24761606 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,23921865 0,24750467 ! response to metal ion GO:0010038 103 70 0,000 0,24223329 0,25051104 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,24223329 0,25039845 ! humoral immune response GO:0006959 86 70 0,000 0,24223329 0,25028597 ! eye development GO:0001654 111 70 0,000 0,24223329 0,25017358 ! amine transport GO:0015837 101 70 0,000 0,24223329 0,25006129 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,24223329 0,24994911 ! muscle cell differentiation GO:0042692 104 71 0,000 0,24523615 0,25293415 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,24523615 0,25282078 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,24523615 0,2527075 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,24523615 0,25259434 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,24523615 0,25248127 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,24822729 0,25544643 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,24822729 0,25533219 ! regulation of blood pressure GO:0008217 107 73 0,000 0,25120675 0,25828141 ! tube morphogenesis GO:0035239 118 73 0,000 0,25120675 0,258166 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,25120675 0,2580507 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,25417456 0,26098281 ! digestion GO:0007586 97 74 0,000 0,25417456 0,26086635 ! blood coagulation GO:0007596 116 75 0,000 0,25713079 0,2637827 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,25713079 0,2636651 ! regulation of ligase activity GO:0051340 114 75 0,000 0,25713079 0,2635476 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,25713079 0,26343021 ! amine biosynthetic process GO:0009309 97 76 0,000 0,26007546 0,26632839 ! tRNA metabolic process GO:0006399 95 76 0,000 0,26007546 0,26620986 ! response to unfolded protein GO:0006986 99 76 0,000 0,26007546 0,26609144 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,26300864 0,26897282 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,26300864 0,26885327 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,26300864 0,26873383 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,26300864 0,2686145 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,26593035 0,27147794 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,26593035 0,2713575 ! cellular respiration GO:0045333 107 79 0,000 0,26884064 0,27420554 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,26884064 0,27408399 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,26884064 0,27396255 ! alcohol catabolic process GO:0046164 104 80 0,000 0,27173957 0,27679407 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,27173957 0,27667154 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,27173957 0,27654912 ! hemostasis GO:0007599 125 81 0,000 0,27462717 0,27936421 ! mRNA transport GO:0051028 121 81 0,000 0,27462717 0,27924071 ! response to protein stimulus GO:0051789 111 81 0,000 0,27462717 0,27911732 ! regulation of neurological system process GO:0031644 122 81 0,000 0,27462717 0,27899403 ! vitamin metabolic process GO:0006766 103 81 0,000 0,27462717 0,27887085 ! detection of stimulus GO:0051606 108 82 0,000 0,27750348 0,28166726 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,28036855 0,28444979 ! regulation of defense response GO:0031347 117 84 0,000 0,28322243 0,28721851 ! sterol metabolic process GO:0016125 120 84 0,000 0,28322243 0,28709193 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,28606515 0,28984575 ! rRNA metabolic process GO:0016072 107 85 0,000 0,28606515 0,28971812 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,28606515 0,2895906 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,28606515 0,28946319 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,2917173 0,29505268 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,2917173 0,29492298 ! female pregnancy GO:0007565 130 87 0,000 0,2917173 0,2947934 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,29452681 0,29750183 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,29452681 0,29737123 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,29452681 0,29724075 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,29452681 0,29711038 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,29732534 0,29980197 ! RNA localization GO:0006403 135 91 0,000 0,30288962 0,30527876 ! ATP metabolic process GO:0046034 137 91 0,000 0,30288962 0,30514504 ! response to virus GO:0009615 122 91 0,000 0,30288962 0,30501144 ! positive regulation of immune response GO:0050778 121 92 0,000 0,30565546 0,30766195 ! sulfur metabolic process GO:0006790 118 92 0,000 0,30565546 0,30752736 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,30841048 0,31016358 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,30841048 0,31002801 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,30841048 0,30989257 ! electron transport chain GO:0022900 123 94 0,000 0,31115472 0,31251348 ! carboxylic acid transport GO:0046942 147 95 0,000 0,31388824 0,31512132 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,31661106 0,31771616 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,31661106 0,3175776 ! protein maturation GO:0051604 129 96 0,000 0,31661106 0,31743916 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,31932323 0,32001892 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,32471579 0,3252815 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,32739626 0,32782386 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,32739626 0,3276812 ! divalent metal ion transport GO:0070838 171 100 0,000 0,32739626 0,32753867 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,32739626 0,32739626