pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6495-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of peptide secretion GO:0002792 6 5 3,000 1,044E-09 2,4E-06 GO:0046676|negative regulation of insulin secretion, ! regulation of protein export from nucleus GO:0046825 6 6 3,000 3,122E-09 3,59E-06 ! organ growth GO:0035265 11 7 3,000 7,262E-09 5,568E-06 ! regulation of growth hormone secretion GO:0060123 11 7 3,000 7,262E-09 4,176E-06 ! cellular response to hormone stimulus GO:0032870 109 74 6,000 1,437E-08 6,611E-06 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 1,448E-08 5,551E-06 ! regulation of DNA replication GO:0006275 75 48 5,000 2,984E-08 9,803E-06 ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 3,811E-08 1,096E-05 ! DNA damage response, signal transduction GO:0042770 96 56 5,000 7,704E-08 1,969E-05 ! DNA damage checkpoint GO:0000077 53 31 4,000 1,204E-07 2,77E-05 ! carbohydrate homeostasis GO:0033500 39 33 4,000 1,672E-07 3,497E-05 GO:0042593|glucose homeostasis, ! DNA integrity checkpoint GO:0031570 57 34 4,000 1,955E-07 3,747E-05 ! regulation of intracellular protein transport GO:0033157 59 35 4,000 2,274E-07 4,023E-05 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 2,767E-07 4,545E-05 ! positive regulation of hormone secretion GO:0046887 24 17 3,000 4,796E-07 7,353E-05 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 4,000 5,834E-07 8,386E-05 ! response to UV GO:0009411 75 46 4,000 9,288E-07 1,257E-04 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 9,501E-07 1,214E-04 ! regulation of insulin secretion GO:0050796 26 21 3,000 1,192E-06 1,443E-04 ! regulation of intracellular transport GO:0032386 78 49 4,000 1,281E-06 1,473E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 2,098E-06 2,297E-04 ! regulation of peptide secretion GO:0002791 34 25 3,000 2,49E-06 2,603E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 3,109E-06 3,109E-04 ! activation of MAPK activity GO:0000187 84 59 4,000 3,263E-06 3,127E-04 ! triglyceride metabolic process GO:0006641 34 28 3,000 3,995E-06 3,675E-04 ! cell cycle checkpoint GO:0000075 108 64 4,000 4,895E-06 4,33E-04 ! negative regulation of secretion GO:0051048 49 31 3,000 6,085E-06 5,184E-04 ! response to X-ray GO:0010165 16 10 2,000 6,624E-06 5,441E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 6,624E-06 5,254E-04 ! neutral lipid metabolic process GO:0006638 41 32 3,000 6,934E-06 5,316E-04 GO:0006639|acylglycerol metabolic process, ! glycerol ether metabolic process GO:0006662 44 34 3,000 8,891E-06 6,596E-04 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 8,891E-06 6,39E-04 ! negative regulation of transport GO:0051051 116 73 4,000 9,386E-06 6,541E-04 ! regulation of hormone secretion GO:0046883 48 36 3,000 1,123E-05 7,595E-04 ! organic ether metabolic process GO:0018904 46 36 3,000 1,123E-05 7,378E-04 ! hormone-mediated signaling GO:0009755 49 36 3,000 1,123E-05 7,173E-04 ! regulation of protein transport GO:0051223 114 76 4,000 1,144E-05 7,112E-04 GO:0070201|regulation of establishment of protein localization, ! response to gamma radiation GO:0010332 20 12 2,000 1,208E-05 7,309E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,554E-05 9,164E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 1,722E-05 9,899E-04 ! regulation of protein localization GO:0032880 132 85 4,000 1,977E-05 1,109E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 2,304E-05 1,262E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 2,766E-05 1,479E-03 ! response to light stimulus GO:0009416 153 96 4,000 3,565E-05 1,863E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 3,681E-05 1,881E-03 ! integrin-mediated signaling pathway GO:0007229 81 49 3,000 3,887E-05 1,944E-03 ! regulation of multicellular organism growth GO:0040014 65 50 3,000 4,213E-05 2,062E-03 ! positive regulation of DNA replication GO:0045740 29 18 2,000 4,405E-05 2,111E-03 ! positive regulation of secretion GO:0051047 71 51 3,000 4,558E-05 2,14E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 5,216E-05 2,4E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 6,12E-05 2,76E-03 ! multicellular organism reproduction GO:0032504 83 57 3,000 7,08E-05 3,132E-03 GO:0048609|reproductive process in a multicellular organism, ! response to peptide hormone stimulus GO:0043434 84 57 3,000 7,08E-05 3,073E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 7,12E-05 3,033E-03 ! cell aging GO:0007569 32 21 2,000 7,12E-05 2,977E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 7,12E-05 2,924E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 8,221E-05 3,317E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 8,221E-05 3,26E-03 ! protein tetramerization GO:0051262 39 22 2,000 8,221E-05 3,205E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 9,428E-05 3,614E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 9,428E-05 3,555E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 9,428E-05 3,497E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 1,074E-04 3,923E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 1,218E-04 4,376E-03 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 1,48E-04 5,235E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,48E-04 5,156E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,48E-04 5,079E-03 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 1,48E-04 5,005E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 1,48E-04 4,932E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 1,48E-04 4,862E-03 ! centrosome duplication GO:0051298 5 5 1,000 1,48E-04 4,793E-03 ! response to UV-C GO:0010225 6 5 1,000 1,48E-04 4,726E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,48E-04 4,662E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 1,48E-04 4,599E-03 GO:0051930|regulation of sensory perception of pain, ! response to ionizing radiation GO:0010212 47 27 2,000 1,54E-04 4,722E-03 ! cell junction assembly GO:0034329 56 28 2,000 1,72E-04 5,205E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 2,214E-04 6,613E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 2,214E-04 6,528E-03 ! male meiosis GO:0007140 7 6 1,000 2,214E-04 6,445E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 2,214E-04 6,365E-03 ! activation of MAPKKK activity GO:0000185 10 6 1,000 2,214E-04 6,286E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 2,214E-04 6,209E-03 ! ER overload response GO:0006983 7 6 1,000 2,214E-04 6,135E-03 ! male sex determination GO:0030238 9 6 1,000 2,214E-04 6,062E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 2,214E-04 5,99E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 2,214E-04 5,921E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 2,214E-04 5,853E-03 ! midbrain development GO:0030901 6 6 1,000 2,214E-04 5,786E-03 ! blastocyst growth GO:0001832 15 6 1,000 2,214E-04 5,721E-03 ! regulation of DNA binding GO:0051101 119 77 3,000 2,288E-04 5,847E-03 ! mammary gland development GO:0030879 57 31 2,000 2,34E-04 5,915E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 2,575E-04 6,438E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 2,825E-04 6,986E-03 ! cell junction organization GO:0034330 63 33 2,000 2,825E-04 6,912E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 3,092E-04 7,485E-03 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 3,092E-04 7,407E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 3,092E-04 7,33E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 3,092E-04 7,256E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 3,092E-04 7,182E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 3,092E-04 7,111E-03 ! response to tumor cell GO:0002347 12 7 1,000 3,092E-04 7,04E-03 ! cell cycle arrest GO:0007050 150 86 3,000 3,497E-04 7,886E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 3,497E-04 7,81E-03 ! interphase GO:0051325 159 88 3,000 3,818E-04 8,444E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 4,112E-04 9,007E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 4,112E-04 8,922E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 4,112E-04 8,838E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 4,112E-04 8,756E-03 ! multicellular organism growth GO:0035264 14 8 1,000 4,112E-04 8,676E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 4,112E-04 8,597E-03 ! induction of an organ GO:0001759 11 8 1,000 4,112E-04 8,52E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 4,112E-04 8,444E-03 ! hormone metabolic process GO:0042445 121 90 3,000 4,159E-04 8,466E-03 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 4,712E-04 9,506E-03 ! double-strand break repair GO:0006302 67 40 2,000 5,017E-04 0,01003347 ! regulation of binding GO:0051098 151 95 3,000 5,107E-04 0,01012678 ! regulation of developmental growth GO:0048638 13 9 1,000 5,273E-04 0,01036609 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 5,273E-04 0,01027824 ! regulation of glycolysis GO:0006110 15 9 1,000 5,273E-04 0,01019187 ! positive regulation of survival gene product expression GO:0045885 13 9 1,000 5,273E-04 0,01010694 ! receptor clustering GO:0043113 15 9 1,000 5,273E-04 0,01002341 ! motor axon guidance GO:0008045 14 9 1,000 5,273E-04 9,941E-03 ! oocyte differentiation GO:0009994 12 9 1,000 5,273E-04 9,86E-03 GO:0048599|oocyte development, ! localization within membrane GO:0051668 15 9 1,000 5,273E-04 9,781E-03 ! positive regulation of DNA binding GO:0043388 57 41 2,000 5,398E-04 9,932E-03 ! positive regulation of binding GO:0051099 59 43 2,000 6,214E-04 0,01134366 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 6,214E-04 0,01125434 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 6,214E-04 0,01116641 ! regulation of B cell proliferation GO:0030888 15 10 1,000 6,575E-04 0,01172273 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 6,575E-04 0,01163256 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 6,575E-04 0,01154376 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 6,575E-04 0,01145631 ! negative regulation of ossification GO:0030279 19 10 1,000 6,575E-04 0,01137017 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 6,575E-04 0,01128532 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 6,575E-04 0,01120172 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 6,575E-04 0,01111936 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 6,651E-04 0,01116518 ! positive regulation of cell cycle GO:0045787 77 45 2,000 7,106E-04 0,01184308 ! virus-host interaction GO:0019048 17 11 1,000 8,016E-04 0,01326361 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 8,016E-04 0,01316887 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 8,016E-04 0,01307547 GO:0000725|recombinational repair, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 8,016E-04 0,01298339 ! regulation of intracellular pH GO:0051453 17 11 1,000 8,016E-04 0,0128926 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 8,016E-04 0,01280307 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 8,016E-04 0,01271477 GO:0042130|negative regulation of T cell proliferation, ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 8,075E-04 0,0127208 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 9,595E-04 0,01501235 ! cell-cell junction assembly GO:0007043 18 12 1,000 9,595E-04 0,01491091 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 9,595E-04 0,01481084 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 9,595E-04 0,0147121 ! peptidyl-lysine modification GO:0018205 18 12 1,000 9,595E-04 0,01461467 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,026E-03 0,01551929 ! positive regulation of cell migration GO:0030335 92 51 2,000 1,026E-03 0,01541785 ! aging GO:0007568 79 52 2,000 1,085E-03 0,01621054 ! nucleotide-excision repair GO:0006289 64 52 2,000 1,085E-03 0,01610595 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,131E-03 0,01667633 ! intermediate filament cytoskeleton organization GO:0045104 23 13 1,000 1,131E-03 0,01657011 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,131E-03 0,01646523 ! regulation of cellular pH GO:0030641 20 13 1,000 1,131E-03 0,01636168 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,131E-03 0,01625942 ! endocrine pancreas development GO:0031018 19 13 1,000 1,131E-03 0,01615843 ! cytokine-mediated signaling pathway GO:0019221 76 54 2,000 1,211E-03 0,01719982 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 1,316E-03 0,01857346 ! regulation of S phase GO:0033261 18 14 1,000 1,316E-03 0,01846021 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,316E-03 0,01834833 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 1,316E-03 0,0182378 ! heterophilic cell adhesion GO:0007157 29 14 1,000 1,316E-03 0,01812859 ! startle response GO:0001964 21 14 1,000 1,316E-03 0,01802068 ! activation of MAPKK activity GO:0000186 21 14 1,000 1,316E-03 0,01791405 ! cellular response to starvation GO:0009267 21 14 1,000 1,316E-03 0,01780867 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,316E-03 0,01770453 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,316E-03 0,0176016 ! intermediate filament-based process GO:0045103 24 14 1,000 1,316E-03 0,01749985 ! axon cargo transport GO:0008088 27 14 1,000 1,316E-03 0,01739928 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,316E-03 0,01729985 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 1,316E-03 0,01720156 ! positive regulation of cell motion GO:0051272 99 56 2,000 1,346E-03 0,01749562 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 1,417E-03 0,01831303 ! negative regulation of kinase activity GO:0033673 100 58 2,000 1,49E-03 0,01915089 ! lipid phosphorylation GO:0046834 23 15 1,000 1,515E-03 0,0193582 ! centrosome cycle GO:0007098 16 15 1,000 1,515E-03 0,01925125 ! regulation of survival gene product expression GO:0045884 20 15 1,000 1,515E-03 0,01914547 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 1,515E-03 0,01904085 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 1,515E-03 0,01893737 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,515E-03 0,018835 ! lung development GO:0030324 94 59 2,000 1,566E-03 0,01936376 ! negative regulation of transferase activity GO:0051348 105 61 2,000 1,724E-03 0,02120475 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,727E-03 0,02112909 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,727E-03 0,0210173 ! oogenesis GO:0048477 23 16 1,000 1,727E-03 0,02090668 ! G1 phase GO:0051318 27 16 1,000 1,727E-03 0,02079722 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,727E-03 0,0206889 ! negative regulation of cell growth GO:0030308 106 62 2,000 1,807E-03 0,02153052 ! respiratory tube development GO:0030323 99 62 2,000 1,807E-03 0,02141954 ! regulation of transcription factor activity GO:0051090 97 63 2,000 1,892E-03 0,02231331 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 1,892E-03 0,02219946 ! signal complex assembly GO:0007172 29 17 1,000 1,952E-03 0,02279501 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,952E-03 0,02267988 ! memory GO:0007613 25 17 1,000 1,952E-03 0,02256592 ! cell-substrate junction assembly GO:0007044 39 17 1,000 1,952E-03 0,02245309 ! neuromuscular junction development GO:0007528 23 17 1,000 1,952E-03 0,02234138 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 1,952E-03 0,02223078 ! cell-cell junction organization GO:0045216 25 17 1,000 1,952E-03 0,02212127 ! negative regulation of cell size GO:0045792 108 64 2,000 1,979E-03 0,02231599 ! respiratory system development GO:0060541 100 64 2,000 1,979E-03 0,02220713 ! protein oligomerization GO:0051259 100 65 2,000 2,069E-03 0,0231046 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 2,191E-03 0,02434435 ! pancreas development GO:0031016 26 18 1,000 2,191E-03 0,02422731 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 2,191E-03 0,02411139 ! prostaglandin metabolic process GO:0006693 31 18 1,000 2,191E-03 0,02399657 GO:0006692|prostanoid metabolic process, ! somitogenesis GO:0001756 24 18 1,000 2,191E-03 0,02388284 ! cellular response to nutrient levels GO:0031669 27 18 1,000 2,191E-03 0,02377019 ! negative regulation of T cell activation GO:0050868 25 18 1,000 2,191E-03 0,02365859 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 2,191E-03 0,02354804 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 2,443E-03 0,02613033 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 2,443E-03 0,02600936 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 2,443E-03 0,0258895 ! response to starvation GO:0042594 30 19 1,000 2,443E-03 0,02577074 ! sex determination GO:0007530 29 19 1,000 2,443E-03 0,02565307 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 2,443E-03 0,02553646 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 2,443E-03 0,02542091 ! protein stabilization GO:0050821 26 19 1,000 2,443E-03 0,0253064 ! positive regulation of phosphorylation GO:0042327 102 70 2,000 2,558E-03 0,02638 ! regulation of catabolic process GO:0009894 106 70 2,000 2,558E-03 0,02626223 ! microtubule-based transport GO:0010970 37 20 1,000 2,707E-03 0,02767381 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 2,707E-03 0,02755136 ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,707E-03 0,02742999 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 2,771E-03 0,02795604 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 2,985E-03 0,0299773 ! protein amino acid acylation GO:0043543 37 21 1,000 2,985E-03 0,02984696 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 2,985E-03 0,02971776 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 2,985E-03 0,02958966 ! regulation of bone mineralization GO:0030500 29 21 1,000 2,985E-03 0,02946267 ! negative regulation of growth GO:0045926 123 75 2,000 3,112E-03 0,03058581 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 3,275E-03 0,03205265 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 3,275E-03 0,03191683 ! leukocyte adhesion GO:0007159 38 22 1,000 3,275E-03 0,03178216 ! vasculogenesis GO:0001570 33 22 1,000 3,275E-03 0,03164863 ! microtubule organizing center organization GO:0031023 28 22 1,000 3,275E-03 0,03151621 GO:0051297|centrosome organization, ! blastocyst development GO:0001824 37 22 1,000 3,275E-03 0,03138489 ! gland development GO:0048732 148 77 2,000 3,352E-03 0,03199399 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 3,578E-03 0,0340045 ! myelination GO:0042552 35 23 1,000 3,578E-03 0,03386457 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 3,578E-03 0,03372578 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 3,578E-03 0,03358812 ! interaction with host GO:0051701 37 23 1,000 3,578E-03 0,03345159 ! regulation of biomineral formation GO:0070167 31 23 1,000 3,578E-03 0,03331615 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 3,578E-03 0,03318181 ! negative regulation of catabolic process GO:0009895 34 23 1,000 3,578E-03 0,03304855 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 3,893E-03 0,03581889 ! mitochondrial membrane organization GO:0007006 39 24 1,000 3,893E-03 0,03567618 ! receptor metabolic process GO:0043112 37 24 1,000 3,893E-03 0,03553461 ! negative regulation of cell development GO:0010721 56 24 1,000 3,893E-03 0,03539416 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 3,893E-03 0,03525481 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 3,893E-03 0,03511656 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 4,221E-03 0,03792594 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 4,221E-03 0,03777837 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 4,283E-03 0,03818358 ! regulation of pH GO:0006885 36 26 1,000 4,562E-03 0,04050896 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 4,562E-03 0,04035315 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 4,562E-03 0,04019854 ! skeletal muscle tissue development GO:0007519 123 87 2,000 4,725E-03 0,04148255 GO:0060538|skeletal muscle organ development, ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 4,914E-03 0,04297655 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 4,914E-03 0,04281376 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 1,000 4,914E-03 0,04265219 ! reproductive developmental process GO:0003006 127 89 2,000 5,035E-03 0,04353562 ! response to organic cyclic substance GO:0014070 47 28 1,000 5,279E-03 0,0454751 ! ensheathment of neurons GO:0007272 43 28 1,000 5,279E-03 0,04530542 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 1,000 5,279E-03 0,04513699 ! positive regulation of catabolic process GO:0009896 40 28 1,000 5,279E-03 0,04496982 ! regulation of B cell activation GO:0050864 42 28 1,000 5,279E-03 0,04480388 ! cell fate commitment GO:0045165 141 92 2,000 5,522E-03 0,04669228 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 5,656E-03 0,04765075 ! hindbrain development GO:0030902 45 30 1,000 6,045E-03 0,05074096 ! adult locomotory behavior GO:0008344 47 30 1,000 6,045E-03 0,05055645 ! regulation of microtubule-based process GO:0032886 58 30 1,000 6,045E-03 0,05037327 ! negative regulation of cell activation GO:0050866 44 30 1,000 6,045E-03 0,05019142 ! in utero embryonic development GO:0001701 147 96 2,000 6,214E-03 0,0514083 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 6,394E-03 0,05271345 ! maintenance of protein location in cell GO:0032507 60 31 1,000 6,446E-03 0,05294547 ! segmentation GO:0035282 41 31 1,000 6,446E-03 0,05275705 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 6,446E-03 0,05256997 ! cell fate specification GO:0001708 37 31 1,000 6,446E-03 0,05238421 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 6,858E-03 0,0555407 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 6,858E-03 0,05534583 ! peripheral nervous system development GO:0007422 53 32 1,000 6,858E-03 0,05515231 ! regulation of protein stability GO:0031647 48 32 1,000 6,858E-03 0,05496014 ! calcium-mediated signaling GO:0019722 50 32 1,000 6,858E-03 0,05476931 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 6,858E-03 0,05457979 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 7,282E-03 0,05775618 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! female gonad development GO:0008585 49 33 1,000 7,282E-03 0,05755771 ! negative regulation of DNA binding GO:0043392 54 33 1,000 7,282E-03 0,05736059 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 7,282E-03 0,05716482 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 7,282E-03 0,05697038 ! cytokinesis GO:0000910 52 33 1,000 7,282E-03 0,05677726 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 7,718E-03 0,059972 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 7,718E-03 0,05977007 ! female gamete generation GO:0007292 43 34 1,000 7,718E-03 0,0595695 ! Notch signaling pathway GO:0007219 56 35 1,000 8,165E-03 0,06281137 ! regulation of action potential in neuron GO:0019228 54 35 1,000 8,165E-03 0,062602 ! maintenance of protein location GO:0045185 65 35 1,000 8,165E-03 0,06239402 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 8,165E-03 0,06218741 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 8,624E-03 0,06546449 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 1,000 8,624E-03 0,06524915 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 8,624E-03 0,06503522 GO:0046660|female sex differentiation, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 9,094E-03 0,06835596 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 9,576E-03 0,07173921 ! regulation of T cell proliferation GO:0042129 58 38 1,000 9,576E-03 0,07150629 ! mesenchymal cell development GO:0014031 64 38 1,000 9,576E-03 0,07127488 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 9,576E-03 0,07104496 ! developmental growth GO:0048589 62 39 1,000 0,01006807 0,07445842 ! cell growth GO:0016049 61 39 1,000 0,01006807 0,07421977 ! synapse organization GO:0050808 55 39 1,000 0,01006807 0,07398264 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,01057157 0,07743505 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,01057157 0,07718922 ! T cell differentiation GO:0030217 65 40 1,000 0,01057157 0,07694495 ! B cell differentiation GO:0030183 62 40 1,000 0,01057157 0,07670222 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01057157 0,07646102 ! endosome transport GO:0016197 71 41 1,000 0,01108602 0,07993054 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,01108602 0,07968076 ! mitochondrial transport GO:0006839 60 42 1,000 0,01161133 0,08319648 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,01161133 0,08293811 ! icosanoid metabolic process GO:0006690 61 42 1,000 0,01161133 0,08268133 ! neuromuscular process GO:0050905 79 43 1,000 0,01214743 0,08623174 ! activation of caspase activity GO:0006919 65 43 1,000 0,01214743 0,08596641 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,01214743 0,08570271 ! regulation of action potential GO:0001508 71 44 1,000 0,01269421 0,08928647 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,01269421 0,08901426 ! positive regulation of defense response GO:0031349 59 45 1,000 0,01325158 0,09264026 ! cell maturation GO:0048469 60 45 1,000 0,01325158 0,09235953 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,01381947 0,09602655 ! regulation of ossification GO:0030278 71 46 1,000 0,01381947 0,09573731 ! histone modification GO:0016570 68 46 1,000 0,01381947 0,09544981 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,01439778 0,09914641 ! endocrine system development GO:0035270 83 47 1,000 0,01439778 0,09885045 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01439778 0,09855625 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,01439778 0,0982638 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,01439778 0,09797308 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01498643 0,10167783 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 1,000 0,01498643 0,10137878 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,01498643 0,10108148 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,01498643 0,10078592 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,01558532 0,10450799 ! germ cell development GO:0007281 68 49 1,000 0,01558532 0,10420419 ! maintenance of location GO:0051235 84 49 1,000 0,01558532 0,10390215 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,01619438 0,10765049 ! lipid modification GO:0030258 73 50 1,000 0,01619438 0,10734026 ! positive regulation of growth GO:0045927 67 50 1,000 0,01619438 0,10703181 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01681351 0,11080537 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,01681351 0,11048879 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,01681351 0,110174 ! adult behavior GO:0030534 80 51 1,000 0,01681351 0,10986101 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01744264 0,1136489 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,01808167 0,11747975 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01873052 0,12135267 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,01873052 0,12101179 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01873052 0,12067282 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01930006 0,12399477 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01930006 0,12364938 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01930006 0,12330591 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01930006 0,12296434 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01930006 0,12262466 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01930006 0,12228685 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01930006 0,1219509 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01930006 0,12161679 ! sleep GO:0030431 11 5 0,000 0,01930006 0,1212845 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01930006 0,12095402 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01930006 0,12062534 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01930006 0,12029845 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01930006 0,11997332 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01930006 0,11964994 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01930006 0,1193283 ! tongue development GO:0043586 6 5 0,000 0,01930006 0,11900838 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01930006 0,11869018 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01930006 0,11837367 ! cobalt ion transport GO:0006824 9 5 0,000 0,01930006 0,11805885 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01930006 0,11774569 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01930006 0,1174342 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01930006 0,11712435 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01930006 0,11681612 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01930006 0,11650952 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01930006 0,11620452 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01930006 0,11590111 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01930006 0,11559929 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01930006 0,11529903 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01930006 0,11500033 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01930006 0,11470317 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01930006 0,11440754 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01930006 0,11411344 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01930006 0,11382084 ! malate metabolic process GO:0006108 7 5 0,000 0,01930006 0,11352974 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01930006 0,11324012 ! behavioral response to pain GO:0048266 7 5 0,000 0,01930006 0,11295198 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01930006 0,1126653 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01930006 0,11238007 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01930006 0,11209628 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01930006 0,11181392 ! mating behavior GO:0007617 6 5 0,000 0,01930006 0,11153298 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01930006 0,11125345 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01930006 0,11097532 ! rhythmic behavior GO:0007622 12 5 0,000 0,01930006 0,11069857 ! copulation GO:0007620 7 5 0,000 0,01930006 0,1104232 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01930006 0,1101492 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01930006 0,10987655 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01930006 0,10960525 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01930006 0,10933529 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01930006 0,10906665 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01930006 0,10879933 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01930006 0,10853332 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01930006 0,1082686 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01930006 0,10800517 ! response to protozoan GO:0001562 9 5 0,000 0,01930006 0,10774303 ! lymph vessel development GO:0001945 7 5 0,000 0,01930006 0,10748215 ! endochondral ossification GO:0001958 12 5 0,000 0,01930006 0,10722253 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01930006 0,10696416 ! parathyroid gland development GO:0060017 8 5 0,000 0,01930006 0,10670704 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01930006 0,10645114 ! anagen GO:0042640 6 5 0,000 0,01930006 0,10619648 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01930006 0,10594302 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01930006 0,10569078 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01930006 0,10543973 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01930006 0,10518987 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01930006 0,1049412 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01930006 0,1046937 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01930006 0,10444736 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01930006 0,10420218 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01930006 0,10395814 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01930006 0,10371525 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01930006 0,10347349 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01930006 0,10323285 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01930006 0,10299333 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01930006 0,10275492 ! ovulation GO:0030728 6 5 0,000 0,01930006 0,10251761 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01930006 0,1022814 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01930006 0,10204627 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01930006 0,10181222 ! response to pH GO:0009268 9 5 0,000 0,01930006 0,10157924 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01930006 0,10134732 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01930006 0,10111646 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01930006 0,10088665 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01930006 0,10065788 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01930006 0,10043015 ! polyol catabolic process GO:0046174 7 5 0,000 0,01930006 0,10020345 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01930006 0,09997776 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01930006 0,09975309 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01930006 0,09952943 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01930006 0,09930677 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01930006 0,0990851 ! urea metabolic process GO:0019627 6 5 0,000 0,01930006 0,09886443 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01930006 0,09864473 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01930006 0,098426 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01930006 0,09820825 ! neutrophil activation GO:0042119 5 5 0,000 0,01930006 0,09799145 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01930006 0,09777561 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01930006 0,09756072 ! response to food GO:0032094 5 5 0,000 0,01930006 0,09734677 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01930006 0,09713376 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01930006 0,09692167 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01930006 0,09671052 ! forebrain neuron development GO:0021884 7 5 0,000 0,01930006 0,09650028 ! melanosome organization GO:0032438 7 5 0,000 0,01930006 0,09629095 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01930006 0,09608253 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01930006 0,095875 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01930006 0,09566838 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01930006 0,09546264 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01930006 0,09525778 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01930006 0,0950538 ! nucleoside transport GO:0015858 6 5 0,000 0,01930006 0,0948507 ! nucleoside salvage GO:0043174 7 5 0,000 0,01930006 0,09464846 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01930006 0,09444708 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01930006 0,09424655 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01930006 0,09404688 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01930006 0,09384805 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01930006 0,09365006 ! depyrimidination GO:0045008 8 5 0,000 0,01930006 0,0934529 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01930006 0,09325657 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01930006 0,09306106 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01930006 0,09286637 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01930006 0,0926725 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01930006 0,09247943 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01930006 0,09228717 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01930006 0,0920957 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01930006 0,09190502 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01930006 0,09171514 ! monocyte differentiation GO:0030224 8 5 0,000 0,01930006 0,09152603 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01930006 0,09133771 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01930006 0,09115016 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01930006 0,09096337 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01930006 0,09077736 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01930006 0,0905921 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01930006 0,09040759 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01930006 0,09022384 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01930006 0,09004083 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01930006 0,08985856 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01930006 0,08967702 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01930006 0,08949622 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01930006 0,08931615 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01930006 0,0891368 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01930006 0,08895817 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01930006 0,08878025 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01930006 0,08860305 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01930006 0,08842655 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01930006 0,08825075 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01930006 0,08807565 ! neural tube patterning GO:0021532 6 5 0,000 0,01930006 0,08790124 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01930006 0,08772752 ! histone demethylation GO:0016577 9 5 0,000 0,01930006 0,08755449 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01930006 0,08738214 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01930006 0,08721047 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01930006 0,08703946 ! enteric nervous system development GO:0048484 8 5 0,000 0,01930006 0,08686913 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01930006 0,08669947 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01930006 0,08653046 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01930006 0,08636211 ! transcription termination GO:0006353 8 5 0,000 0,01930006 0,08619442 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01930006 0,08602738 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01930006 0,08586098 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01930006 0,08569523 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01930006 0,08553011 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01930006 0,08536563 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01930006 0,08520178 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01930006 0,08503856 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01930006 0,08487596 ! apical protein localization GO:0045176 6 5 0,000 0,01930006 0,08471398 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01930006 0,08455262 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01930006 0,08439188 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01930006 0,08423174 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01930006 0,08407221 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01930006 0,08391328 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01930006 0,08375496 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01930006 0,08359723 ! glial cell migration GO:0008347 10 5 0,000 0,01930006 0,08344009 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01930006 0,08328354 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01930006 0,08312758 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01930006 0,0829722 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01930006 0,0828174 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01930006 0,08266318 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01930006 0,08250953 ! neural plate development GO:0001840 6 5 0,000 0,01930006 0,08235645 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01930006 0,08220394 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01930006 0,08205199 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01930006 0,0819006 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01930006 0,08174977 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01930006 0,0815995 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01930006 0,08144977 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01930006 0,0813006 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01930006 0,08115197 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01930006 0,08100388 ! spindle assembly GO:0051225 5 5 0,000 0,01930006 0,08085633 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01930006 0,08070932 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01930006 0,08056284 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01930006 0,0804169 ! organ regeneration GO:0031100 7 5 0,000 0,01930006 0,08027148 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01930006 0,08012658 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01930006 0,07998221 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01930006 0,07983836 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01930006 0,07969502 GO:0055081|anion homeostasis, ! developmental maturation GO:0021700 75 57 1,000 0,02073518 0,0854676 ! gonad development GO:0008406 79 57 1,000 0,02073518 0,08531471 ! viral reproductive process GO:0022415 87 58 1,000 0,0214225 0,08798525 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,0214225 0,08782841 ! actin filament organization GO:0007015 95 59 1,000 0,02211922 0,09052349 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,02282527 0,09324709 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,02282527 0,09308176 ! tRNA transcription GO:0009304 11 6 0,000 0,02311579 0,09409968 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02311579 0,09393342 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02311579 0,09376775 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02311579 0,09360267 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02311579 0,09343817 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02311579 0,09327424 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02311579 0,09311089 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02311579 0,09294811 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02311579 0,09278589 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02311579 0,09262425 ! prostate gland development GO:0030850 9 6 0,000 0,02311579 0,09246316 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02311579 0,09230263 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02311579 0,09214266 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02311579 0,09198325 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02311579 0,09182438 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02311579 0,09166606 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02311579 0,09150829 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02311579 0,09135106 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02311579 0,09119437 ! neuron adhesion GO:0007158 9 6 0,000 0,02311579 0,09103821 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02311579 0,09088259 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02311579 0,0907275 ! signal peptide processing GO:0006465 8 6 0,000 0,02311579 0,09057294 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02311579 0,09041891 ! mRNA stabilization GO:0048255 15 6 0,000 0,02311579 0,09026539 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02311579 0,0901124 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02311579 0,08995993 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02311579 0,08980797 ! opsonization GO:0008228 8 6 0,000 0,02311579 0,08965652 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02311579 0,08950558 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02311579 0,08935515 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02311579 0,08920523 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02311579 0,08905581 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02311579 0,08890688 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02311579 0,08875846 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02311579 0,08861053 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02311579 0,08846309 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02311579 0,08831614 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02311579 0,08816968 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02311579 0,0880237 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02311579 0,08787821 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02311579 0,0877332 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02311579 0,08758866 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02311579 0,0874446 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02311579 0,08730101 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02311579 0,0871579 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02311579 0,08701525 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02311579 0,08687307 ! thymic T cell selection GO:0045061 12 6 0,000 0,02311579 0,08673135 ! protein lipoylation GO:0009249 10 6 0,000 0,02311579 0,08659009 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02311579 0,0864493 ! pigment granule organization GO:0048753 11 6 0,000 0,02311579 0,08630896 ! drug transport GO:0015893 6 6 0,000 0,02311579 0,08616907 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02311579 0,08602964 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02311579 0,08589066 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02311579 0,08575212 ! histidine metabolic process GO:0006547 6 6 0,000 0,02311579 0,08561404 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02311579 0,08547639 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02311579 0,08533919 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02311579 0,08520243 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02311579 0,08506611 ! adenohypophysis development GO:0021984 10 6 0,000 0,02311579 0,08493022 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02311579 0,08479476 ! hyperosmotic response GO:0006972 8 6 0,000 0,02311579 0,08465974 ! microtubule nucleation GO:0007020 10 6 0,000 0,02311579 0,08452515 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02311579 0,08439098 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02311579 0,08425724 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02311579 0,08412392 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02311579 0,08399102 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02311579 0,08385854 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02311579 0,08372648 ! response to dietary excess GO:0002021 7 6 0,000 0,02311579 0,08359484 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02311579 0,08346361 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02311579 0,08333278 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02311579 0,08320237 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02311579 0,08307237 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02311579 0,08294277 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02311579 0,08281358 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02311579 0,08268479 ! neuron apoptosis GO:0051402 8 6 0,000 0,02311579 0,08255639 ! organic alcohol transport GO:0015850 9 6 0,000 0,02311579 0,0824284 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02311579 0,0823008 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02311579 0,0821736 ! carnitine transport GO:0015879 8 6 0,000 0,02311579 0,08204679 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02311579 0,08192036 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02311579 0,08179433 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02311579 0,08166869 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02311579 0,08154343 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02311579 0,08141856 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02311579 0,08129406 ! parturition GO:0007567 12 6 0,000 0,02311579 0,08116995 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02311579 0,08104621 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02311579 0,08092286 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02311579 0,08079987 ! spindle checkpoint GO:0031577 14 6 0,000 0,02311579 0,08067726 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02311579 0,08055503 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02311579 0,08043316 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02311579 0,08031166 ! macrophage differentiation GO:0030225 10 6 0,000 0,02311579 0,08019052 ! astrocyte development GO:0014002 14 6 0,000 0,02311579 0,08006975 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02311579 0,07994935 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02311579 0,0798293 ! interaction with symbiont GO:0051702 8 6 0,000 0,02311579 0,07970962 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02311579 0,07959029 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02311579 0,07947133 ! eating behavior GO:0042755 6 6 0,000 0,02311579 0,07935271 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02311579 0,07923445 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02311579 0,07911654 ! response to copper ion GO:0046688 9 6 0,000 0,02311579 0,07899898 ! DNA topological change GO:0006265 8 6 0,000 0,02311579 0,07888178 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02311579 0,07876491 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02311579 0,0786484 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02311579 0,07853223 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02311579 0,0784164 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02311579 0,07830091 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02311579 0,07818576 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02311579 0,07807095 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02311579 0,07795648 ! gas homeostasis GO:0033483 11 6 0,000 0,02311579 0,07784234 ! hair follicle maturation GO:0048820 7 6 0,000 0,02311579 0,07772853 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02311579 0,07761506 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02311579 0,07750192 ! Schwann cell development GO:0014044 14 6 0,000 0,02311579 0,07738911 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02311579 0,07727662 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02311579 0,07716447 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02311579 0,07705263 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02311579 0,07694112 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02311579 0,07682994 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02311579 0,07671907 ! histone ubiquitination GO:0016574 7 6 0,000 0,02311579 0,07660853 ! regulation of meiosis GO:0040020 10 6 0,000 0,02311579 0,0764983 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02311579 0,07638839 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02311579 0,07627879 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02311579 0,07616951 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02311579 0,07606054 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02311579 0,07595188 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02311579 0,07584353 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02311579 0,07573549 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02311579 0,07562776 ! receptor internalization GO:0031623 9 6 0,000 0,02311579 0,07552034 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02311579 0,07541322 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02311579 0,0753064 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02311579 0,07519988 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02311579 0,07509367 ! protein deubiquitination GO:0016579 8 6 0,000 0,02311579 0,07498775 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02311579 0,07488214 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02311579 0,07477682 ! axonal fasciculation GO:0007413 9 6 0,000 0,02311579 0,07467179 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02311579 0,07456706 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02311579 0,07446263 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02311579 0,07435848 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02311579 0,07425463 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02311579 0,07415107 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02311579 0,07404779 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02311579 0,07394481 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02311579 0,07384211 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02311579 0,07373969 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02311579 0,07363756 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02311579 0,07353571 ! adult feeding behavior GO:0008343 6 6 0,000 0,02311579 0,07343414 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02311579 0,07333285 ! pigment granule transport GO:0051904 12 6 0,000 0,02311579 0,07323184 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02311579 0,07313111 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02311579 0,07303065 ! catecholamine transport GO:0051937 7 6 0,000 0,02311579 0,07293048 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02311579 0,07283057 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02311579 0,07273094 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02311579 0,07263158 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02311579 0,07253249 ! protein prenylation GO:0018342 10 6 0,000 0,02311579 0,07243367 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02311579 0,07233512 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02311579 0,07223684 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02311579 0,07213883 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02311579 0,07204108 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02311579 0,0719436 ! meiosis GO:0007126 96 61 1,000 0,02354056 0,07316661 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,02354056 0,07306787 ! meiotic cell cycle GO:0051321 97 62 1,000 0,02426502 0,07521503 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,02499857 0,07738455 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,02499857 0,07728053 ! viral reproduction GO:0016032 92 63 1,000 0,02499857 0,0771768 ! regulation of lipase activity GO:0060191 109 63 1,000 0,02499857 0,07707335 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,02574113 0,07925649 ! reproductive structure development GO:0048608 90 65 1,000 0,02649261 0,08146125 ! regulation of caspase activity GO:0043281 97 65 1,000 0,02649261 0,08135249 ! B cell activation GO:0042113 104 65 1,000 0,02649261 0,08124402 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,0269169 0,08243523 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,0269169 0,08232561 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,0269169 0,08221628 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,0269169 0,08210724 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,0269169 0,08199849 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0269169 0,08189003 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,0269169 0,08178185 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0269169 0,08167396 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,0269169 0,08156635 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,0269169 0,08145903 ! reproductive behavior GO:0019098 12 7 0,000 0,0269169 0,08135198 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,0269169 0,08124522 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,0269169 0,08113874 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,0269169 0,08103254 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,0269169 0,08092661 ! oligopeptide transport GO:0006857 11 7 0,000 0,0269169 0,08082097 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,0269169 0,08071559 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,0269169 0,0806105 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,0269169 0,08050567 ! RNA methylation GO:0001510 11 7 0,000 0,0269169 0,08040112 ! pericardium development GO:0060039 8 7 0,000 0,0269169 0,08029684 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,0269169 0,08019282 ! fibril organization GO:0043206 13 7 0,000 0,0269169 0,08008908 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,0269169 0,07998561 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0269169 0,0798824 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,0269169 0,07977946 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,0269169 0,07967678 ! lipoprotein transport GO:0042953 9 7 0,000 0,0269169 0,07957437 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,0269169 0,07947222 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0269169 0,07937033 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0269169 0,07926871 ! estrogen metabolic process GO:0008210 14 7 0,000 0,0269169 0,07916734 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,0269169 0,07906623 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,0269169 0,07896538 ! chemosensory behavior GO:0007635 9 7 0,000 0,0269169 0,07886479 ! microtubule bundle formation GO:0001578 8 7 0,000 0,0269169 0,07876445 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,0269169 0,07866437 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,0269169 0,07856454 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,0269169 0,07846497 ! leukocyte degranulation GO:0043299 10 7 0,000 0,0269169 0,07836565 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,0269169 0,07826657 ! reflex GO:0060004 12 7 0,000 0,0269169 0,07816775 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0269169 0,07806918 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,0269169 0,07797086 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0269169 0,07787278 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,0269169 0,07777495 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,0269169 0,07767737 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0269169 0,07758003 ! spinal cord patterning GO:0021511 7 7 0,000 0,0269169 0,07748293 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,0269169 0,07738608 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,0269169 0,07728946 ! adrenal gland development GO:0030325 17 7 0,000 0,0269169 0,07719309 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,0269169 0,07709696 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,0269169 0,07700107 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,0269169 0,07690542 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,0269169 0,07681 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,0269169 0,07671482 ! endosome organization GO:0007032 10 7 0,000 0,0269169 0,07661988 ! thyroid hormone generation GO:0006590 11 7 0,000 0,0269169 0,07652517 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,0269169 0,07643069 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,0269169 0,07633645 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,0269169 0,07624244 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0269169 0,07614866 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,0269169 0,07605511 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0269169 0,07596179 ! galactose metabolic process GO:0006012 10 7 0,000 0,0269169 0,0758687 ! vesicle fusion GO:0006906 15 7 0,000 0,0269169 0,07577584 ! intracellular pH reduction GO:0051452 10 7 0,000 0,0269169 0,0756832 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,0269169 0,07559079 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,0269169 0,07549861 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,0269169 0,07540665 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,0269169 0,07531492 ! retinol metabolic process GO:0042572 9 7 0,000 0,0269169 0,0752234 ! behavioral fear response GO:0001662 13 7 0,000 0,0269169 0,07513211 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,0269169 0,07504104 ! rRNA modification GO:0000154 12 7 0,000 0,0269169 0,07495019 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0269169 0,07485957 ! response to UV-B GO:0010224 11 7 0,000 0,0269169 0,07476915 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,0269169 0,07467896 ! intermediate filament organization GO:0045109 11 7 0,000 0,0269169 0,07458899 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,0269169 0,07449923 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,0269169 0,07440969 ! fibrinolysis GO:0042730 9 7 0,000 0,0269169 0,07432036 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,0269169 0,07423125 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,0269169 0,07414235 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,0269169 0,07405366 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,0269169 0,07396519 ! response to tropane GO:0014073 13 7 0,000 0,0269169 0,07387692 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,0269169 0,07378887 ! melanosome localization GO:0032400 10 7 0,000 0,0269169 0,07370102 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,0269169 0,07361339 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,0269169 0,07352596 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,0269169 0,07343874 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,0269169 0,07335173 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,0269169 0,07326492 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,0269169 0,07317832 ! mast cell activation GO:0045576 9 7 0,000 0,0269169 0,07309192 ! multicellular organismal aging GO:0010259 11 7 0,000 0,0269169 0,07300573 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,0269169 0,07291974 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,0269169 0,07283395 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,0269169 0,07274837 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,0269169 0,07266298 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,0269169 0,0725778 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,0269169 0,07249281 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,0269169 0,07240802 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,0269169 0,07232343 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,0269169 0,07223904 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,0269169 0,07215485 ! regulation of lipid transport GO:0032368 13 7 0,000 0,0269169 0,07207085 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,0269169 0,07198705 ! neuroblast proliferation GO:0007405 13 7 0,000 0,0269169 0,07190344 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,0269169 0,07182002 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,0269169 0,0717368 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,0269169 0,07165377 ! diuresis GO:0030146 12 7 0,000 0,0269169 0,07157094 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,0269169 0,07148829 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,0269169 0,07140584 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0269169 0,07132357 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,0269169 0,0712415 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0269169 0,07115961 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0269169 0,07107791 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0269169 0,0709964 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,0269169 0,07091507 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,0269169 0,07083394 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,0269169 0,07075298 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,0269169 0,07067221 ! lymph node development GO:0048535 9 7 0,000 0,0269169 0,07059163 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,0269169 0,07051123 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,0269169 0,07043101 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0269169 0,07035098 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,0269169 0,07027112 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,0269169 0,07019145 ! ATP catabolic process GO:0006200 10 7 0,000 0,0269169 0,07011196 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,0269169 0,07003265 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,0269169 0,06995351 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,0269169 0,06987456 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,0269169 0,06979578 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,0269169 0,06971718 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,0269169 0,06963876 ! muscle adaptation GO:0043500 12 7 0,000 0,0269169 0,06956052 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,0269169 0,06948245 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,0269169 0,06940455 ! retina homeostasis GO:0001895 9 7 0,000 0,0269169 0,06932683 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,0269169 0,06924928 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,0269169 0,06917191 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,0269169 0,06909471 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,0269169 0,06901768 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,0269169 0,06894082 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0269169 0,06886414 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,02725295 0,06964642 ! axon guidance GO:0007411 99 66 1,000 0,02725295 0,06956912 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,02802205 0,07145313 ! learning or memory GO:0007611 123 68 1,000 0,02879985 0,07335511 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,02879985 0,07327396 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,02958627 0,07519163 ! response to drug GO:0042493 108 69 1,000 0,02958627 0,07510864 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,03038123 0,0770417 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03070343 0,077773 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03070343 0,07768744 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,03070343 0,07760207 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03070343 0,07751689 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03070343 0,07743189 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03070343 0,07734708 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03070343 0,07726246 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03070343 0,07717802 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03070343 0,07709376 ! phosphate transport GO:0006817 10 8 0,000 0,03070343 0,07700969 ! N-glycan processing GO:0006491 12 8 0,000 0,03070343 0,0769258 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03070343 0,07684209 ! UTP metabolic process GO:0046051 8 8 0,000 0,03070343 0,07675857 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03070343 0,07667523 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03070343 0,07659207 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,03070343 0,07650908 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03070343 0,07642628 ! succinate metabolic process GO:0006105 14 8 0,000 0,03070343 0,07634366 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03070343 0,07626121 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03070343 0,07617895 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03070343 0,07609686 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03070343 0,07601495 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03070343 0,07593321 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03070343 0,07585165 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03070343 0,07577026 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03070343 0,07568905 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03070343 0,07560801 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03070343 0,07552715 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03070343 0,07544646 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03070343 0,07536594 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03070343 0,07528559 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03070343 0,07520541 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03070343 0,07512541 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03070343 0,07504557 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03070343 0,07496591 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03070343 0,07488641 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03070343 0,07480708 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03070343 0,07472792 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03070343 0,07464893 ! melanin metabolic process GO:0006582 12 8 0,000 0,03070343 0,0745701 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03070343 0,07449144 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03070343 0,07441294 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03070343 0,07433462 ! macrophage activation GO:0042116 12 8 0,000 0,03070343 0,07425645 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03070343 0,07417845 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03070343 0,07410061 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03070343 0,07402294 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03070343 0,07394543 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03070343 0,07386808 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03070343 0,07379089 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03070343 0,07371387 ! ruffle organization GO:0031529 11 8 0,000 0,03070343 0,073637 ! osteoblast development GO:0002076 13 8 0,000 0,03070343 0,0735603 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03070343 0,07348375 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03070343 0,07340736 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03070343 0,07333114 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03070343 0,07325507 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03070343 0,07317915 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03070343 0,0731034 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03070343 0,0730278 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03070343 0,07295236 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03070343 0,07287707 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03070343 0,07280194 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03070343 0,07272697 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03070343 0,07265214 ! segment specification GO:0007379 10 8 0,000 0,03070343 0,07257748 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03070343 0,07250296 ! cellular extravasation GO:0045123 11 8 0,000 0,03070343 0,0724286 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03070343 0,07235439 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03070343 0,07228033 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03070343 0,07220643 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03070343 0,07213267 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03070343 0,07205907 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03070343 0,07198561 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03070343 0,07191231 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03070343 0,07183915 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03070343 0,07176614 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03070343 0,07169328 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03070343 0,07162057 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03070343 0,07154801 ! icosanoid secretion GO:0032309 12 8 0,000 0,03070343 0,07147559 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03070343 0,07140332 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03070343 0,0713312 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03070343 0,07125922 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03070343 0,07118738 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03070343 0,07111569 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03070343 0,07104415 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03070343 0,07097275 ! sterol catabolic process GO:0016127 9 8 0,000 0,03070343 0,07090149 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03070343 0,07083038 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03070343 0,0707594 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03070343 0,07068857 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03070343 0,07061788 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03070343 0,07054734 ! prophase GO:0051324 11 8 0,000 0,03070343 0,07047693 ! S phase GO:0051320 8 8 0,000 0,03070343 0,07040666 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03070343 0,07033654 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03070343 0,07026655 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03070343 0,0701967 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03070343 0,070127 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03070343 0,07005743 ! hormone catabolic process GO:0042447 13 8 0,000 0,03070343 0,06998799 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03070343 0,0699187 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03070343 0,06984954 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03070343 0,06978052 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03070343 0,06971163 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03070343 0,06964288 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03070343 0,06957427 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03070343 0,06950579 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03070343 0,06943745 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03070343 0,06936924 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03070343 0,06930116 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03070343 0,06923322 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03070343 0,06916541 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03070343 0,06909773 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03070343 0,06903019 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03070343 0,06896278 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,03118465 0,06997531 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,03118465 0,06990711 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,03199646 0,07165712 ! response to hypoxia GO:0001666 132 72 1,000 0,03199646 0,07158741 ! mitochondrion organization GO:0007005 104 73 1,000 0,03281658 0,07335097 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,03281658 0,07327975 ! response to oxygen levels GO:0070482 137 74 1,000 0,03364495 0,07505662 ! protein import into nucleus GO:0006606 118 74 1,000 0,03364495 0,07498389 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03364495 0,0749113 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03447544 0,07668619 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03447544 0,07661209 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03447544 0,07653814 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03447544 0,07646434 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03447544 0,07639067 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03447544 0,07631715 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,03447544 0,07624377 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03447544 0,07617052 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03447544 0,07609742 ! GTP metabolic process GO:0046039 9 9 0,000 0,03447544 0,07602446 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03447544 0,07595164 ! social behavior GO:0035176 14 9 0,000 0,03447544 0,07587896 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03447544 0,07580642 ! artery development GO:0060840 19 9 0,000 0,03447544 0,07573402 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03447544 0,07566175 ! response to pain GO:0048265 16 9 0,000 0,03447544 0,07558962 ! protein complex disassembly GO:0043241 17 9 0,000 0,03447544 0,07551763 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03447544 0,07544578 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03447544 0,07537406 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03447544 0,07530248 ! lung alveolus development GO:0048286 17 9 0,000 0,03447544 0,07523104 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03447544 0,07515973 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03447544 0,07508856 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03447544 0,07501752 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03447544 0,07494661 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03447544 0,07487584 ! protein targeting to ER GO:0045047 19 9 0,000 0,03447544 0,0748052 ! T cell selection GO:0045058 18 9 0,000 0,03447544 0,0747347 ! endoderm development GO:0007492 12 9 0,000 0,03447544 0,07466433 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03447544 0,07459409 GO:0006688|glycosphingolipid biosynthetic process, ! arginine catabolic process GO:0006527 10 9 0,000 0,03447544 0,07452398 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03447544 0,07445401 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03447544 0,07438416 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03447544 0,07431445 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03447544 0,07424487 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03447544 0,07417541 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03447544 0,07410609 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03447544 0,0740369 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03447544 0,07396783 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03447544 0,0738989 ! mannose metabolic process GO:0006013 9 9 0,000 0,03447544 0,07383009 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03447544 0,07376141 ! epithelial cell development GO:0002064 10 9 0,000 0,03447544 0,07369286 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03447544 0,07362443 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03447544 0,07355614 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03447544 0,07348797 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03447544 0,07341992 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03447544 0,073352 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03447544 0,07328421 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03447544 0,07321654 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03447544 0,073149 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,03447544 0,07308158 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03447544 0,07301429 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03447544 0,07294712 ! DNA ligation GO:0006266 14 9 0,000 0,03447544 0,07288007 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03447544 0,07281315 ! response to amine stimulus GO:0014075 13 9 0,000 0,03447544 0,07274634 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03447544 0,07267967 ! erythrocyte development GO:0048821 11 9 0,000 0,03447544 0,07261311 ! renal water homeostasis GO:0003091 14 9 0,000 0,03447544 0,07254668 ! postreplication repair GO:0006301 11 9 0,000 0,03447544 0,07248036 ! mRNA cleavage GO:0006379 13 9 0,000 0,03447544 0,07241417 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03447544 0,0723481 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03447544 0,07228215 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03447544 0,07221632 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03447544 0,07215061 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03447544 0,07208501 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03447544 0,07201954 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03447544 0,07195419 ! acid secretion GO:0046717 14 9 0,000 0,03447544 0,07188895 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03447544 0,07182384 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03447544 0,07175884 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03447544 0,07169396 ! purine base metabolic process GO:0006144 18 9 0,000 0,03447544 0,07162919 ! thymus development GO:0048538 15 9 0,000 0,03447544 0,07156455 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03447544 0,07150001 ! spleen development GO:0048536 15 9 0,000 0,03447544 0,0714356 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03447544 0,0713713 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03447544 0,07130712 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03447544 0,07124305 ! detection of calcium ion GO:0005513 13 9 0,000 0,03447544 0,0711791 ! blastocyst formation GO:0001825 12 9 0,000 0,03447544 0,07111526 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03447544 0,07105154 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03447544 0,07098793 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03447544 0,07092443 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03447544 0,07086105 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03447544 0,07079778 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03447544 0,07073463 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03447544 0,07067158 ! prepulse inhibition GO:0060134 14 9 0,000 0,03447544 0,07060865 ! embryonic placenta development GO:0001892 12 9 0,000 0,03447544 0,07054583 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03447544 0,07048313 ! insulin secretion GO:0030073 17 9 0,000 0,03447544 0,07042053 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03447544 0,07035804 ! response to nicotine GO:0035094 16 9 0,000 0,03447544 0,07029567 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03447544 0,07023341 ! nucleus localization GO:0051647 15 9 0,000 0,03447544 0,07017125 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03447544 0,07010921 ! response to nutrient GO:0007584 104 75 1,000 0,03448147 0,07005953 ! nuclear import GO:0051170 121 75 1,000 0,03448147 0,06999769 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,03617872 0,07337835 ! sex differentiation GO:0007548 105 77 1,000 0,03617872 0,0733137 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,03703929 0,07499152 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,03703929 0,07492557 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,03790774 0,07661493 ! T cell activation GO:0042110 134 79 1,000 0,03790774 0,07654767 ! regulation of lyase activity GO:0051339 133 79 1,000 0,03790774 0,07648052 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03823299 0,07706913 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03823299 0,07700165 ! neuron fate specification GO:0048665 11 10 0,000 0,03823299 0,07693428 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03823299 0,07686703 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03823299 0,0767999 ! thyroid gland development GO:0030878 19 10 0,000 0,03823299 0,07673288 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03823299 0,07666598 ! synapsis GO:0007129 13 10 0,000 0,03823299 0,0765992 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03823299 0,07653253 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03823299 0,07646598 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03823299 0,07639955 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03823299 0,07633323 ! sulfate transport GO:0008272 12 10 0,000 0,03823299 0,07626703 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03823299 0,07620094 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,03823299 0,07613496 ! androgen metabolic process GO:0008209 13 10 0,000 0,03823299 0,0760691 ! phospholipid efflux GO:0033700 16 10 0,000 0,03823299 0,07600335 ! hippocampus development GO:0021766 19 10 0,000 0,03823299 0,07593772 ! blood vessel remodeling GO:0001974 21 10 0,000 0,03823299 0,0758722 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03823299 0,07580679 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03823299 0,0757415 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,03823299 0,07567632 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03823299 0,07561125 ! pathogenesis GO:0009405 13 10 0,000 0,03823299 0,07554629 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03823299 0,07548144 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03823299 0,07541671 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03823299 0,07535208 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,03823299 0,07528757 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03823299 0,07522317 ! melanocyte differentiation GO:0030318 15 10 0,000 0,03823299 0,07515887 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03823299 0,07509469 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,03823299 0,07503061 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03823299 0,07496665 ! B cell proliferation GO:0042100 14 10 0,000 0,03823299 0,07490279 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03823299 0,07483905 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,03823299 0,07477541 ! forebrain cell migration GO:0021885 17 10 0,000 0,03823299 0,07471188 ! lipid digestion GO:0044241 15 10 0,000 0,03823299 0,07464846 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03823299 0,07458514 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03823299 0,07452193 ! UV protection GO:0009650 14 10 0,000 0,03823299 0,07445883 ! entry into host cell GO:0030260 20 10 0,000 0,03823299 0,07439584 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03823299 0,07433295 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03823299 0,07427017 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03823299 0,07420749 ! regulation of bone resorption GO:0045124 24 10 0,000 0,03823299 0,07414492 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03823299 0,07408246 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03823299 0,0740201 ! regulation of organ growth GO:0046620 11 10 0,000 0,03823299 0,07395785 ! response to dsRNA GO:0043331 18 10 0,000 0,03823299 0,0738957 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03823299 0,07383365 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03823299 0,07377171 ! embryonic axis specification GO:0000578 12 10 0,000 0,03823299 0,07370987 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03823299 0,07364814 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03823299 0,07358651 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03823299 0,07352498 ! cranial nerve development GO:0021545 12 10 0,000 0,03823299 0,07346356 ! fucose catabolic process GO:0019317 16 10 0,000 0,03823299 0,07340224 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,03823299 0,07334102 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03823299 0,0732799 ! protein sumoylation GO:0016925 12 10 0,000 0,03823299 0,07321888 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03823299 0,07315797 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03823299 0,07309716 ! zymogen activation GO:0031638 14 10 0,000 0,03823299 0,07303645 ! salivary gland development GO:0007431 22 10 0,000 0,03823299 0,07297583 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03823299 0,07291532 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03823299 0,07285491 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03823299 0,0727946 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,03823299 0,07273439 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,03823299 0,07267428 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03823299 0,07261427 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03823299 0,07255436 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03823299 0,07249454 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03823299 0,07243483 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03823299 0,07237521 ! detection of bacterium GO:0016045 10 10 0,000 0,03823299 0,07231569 ! embryonic gut development GO:0048566 11 10 0,000 0,03823299 0,07225627 ! activation of innate immune response GO:0002218 10 10 0,000 0,03823299 0,07219695 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03823299 0,07213772 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03823299 0,07207859 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,03823299 0,07201956 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03823299 0,07196062 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03823299 0,07190178 ! protein localization in nucleus GO:0034504 133 80 1,000 0,03878398 0,07287839 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,03966795 0,0744786 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,03966795 0,07441785 ! regulation of neurological system process GO:0031644 122 81 1,000 0,03966795 0,0743572 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,03966795 0,07429665 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,04055957 0,07590481 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,04145878 0,07752455 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,04145878 0,07746157 ! rRNA transcription GO:0009303 17 11 0,000 0,04197613 0,07836453 ! respiratory burst GO:0045730 14 11 0,000 0,04197613 0,07830098 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04197613 0,07823752 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04197613 0,07817417 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04197613 0,07811093 ! filopodium assembly GO:0046847 19 11 0,000 0,04197613 0,07804778 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04197613 0,07798474 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04197613 0,0779218 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,04197613 0,07785896 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04197613 0,07779622 ! mating GO:0007618 14 11 0,000 0,04197613 0,07773358 ! T cell proliferation GO:0042098 20 11 0,000 0,04197613 0,07767104 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04197613 0,07760861 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04197613 0,07754627 ! bone resorption GO:0045453 16 11 0,000 0,04197613 0,07748403 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04197613 0,0774219 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04197613 0,07735986 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04197613 0,07729792 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,04197613 0,07723608 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04197613 0,07717434 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04197613 0,0771127 ! syncytium formation GO:0006949 15 11 0,000 0,04197613 0,07705116 ! plasma membrane organization GO:0007009 18 11 0,000 0,04197613 0,07698972 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04197613 0,07692837 ! focal adhesion formation GO:0048041 24 11 0,000 0,04197613 0,07686712 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04197613 0,07680597 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04197613 0,07674492 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04197613 0,07668396 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04197613 0,0766231 ! adult heart development GO:0007512 11 11 0,000 0,04197613 0,07656234 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04197613 0,07650167 ! temperature homeostasis GO:0001659 16 11 0,000 0,04197613 0,0764411 ! L-glutamate transport GO:0015813 16 11 0,000 0,04197613 0,07638062 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04197613 0,07632024 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04197613 0,07625996 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04197613 0,07619977 ! stem cell development GO:0048864 29 11 0,000 0,04197613 0,07613967 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04197613 0,07607967 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04197613 0,07601977 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04197613 0,07595996 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04197613 0,07590024 ! vasoconstriction GO:0042310 15 11 0,000 0,04197613 0,07584062 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04197613 0,07578109 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04197613 0,07572165 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04197613 0,07566231 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04197613 0,07560306 ! ribosome assembly GO:0042255 13 11 0,000 0,04197613 0,0755439 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04197613 0,07548484 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04197613 0,07542586 ! chromatin silencing GO:0006342 19 11 0,000 0,04197613 0,07536698 ! nucleosome positioning GO:0016584 13 11 0,000 0,04197613 0,07530819 ! T cell homeostasis GO:0043029 20 11 0,000 0,04197613 0,0752495 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04197613 0,07519089 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04197613 0,07513238 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04197613 0,07507395 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04197613 0,07501562 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04197613 0,07495738 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04197613 0,07489923 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04197613 0,07484117 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04197613 0,07478319 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04197613 0,07472531 ! male genitalia development GO:0030539 13 11 0,000 0,04197613 0,07466752 ! cholesterol efflux GO:0033344 19 11 0,000 0,04197613 0,07460982 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04197613 0,0745522 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04197613 0,07449468 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04197613 0,07443724 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04197613 0,0743799 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04197613 0,07432264 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04197613 0,07426547 ! defense response to fungus GO:0050832 12 11 0,000 0,04197613 0,07420838 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04197613 0,07415139 ! lysogeny GO:0030069 18 11 0,000 0,04197613 0,07409448 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04197613 0,07403766 ! acrosome reaction GO:0007340 13 11 0,000 0,04197613 0,07398092 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04197613 0,07392428 ! regulation of defense response GO:0031347 117 84 1,000 0,0423655 0,07455291 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,04327967 0,07610339 ! regulation of membrane potential GO:0042391 128 85 1,000 0,04327967 0,07604525 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,04327967 0,0759872 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,0442012 0,07754597 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,04513005 0,07911517 ! lactation GO:0007595 20 12 0,000 0,04570492 0,08006193 ! reproductive cellular process GO:0048610 14 12 0,000 0,04570492 0,080001 ! tRNA modification GO:0006400 14 12 0,000 0,04570492 0,07994016 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04570492 0,07987942 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04570492 0,07981876 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04570492 0,0797582 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04570492 0,07969774 ! non-recombinational repair GO:0000726 19 12 0,000 0,04570492 0,07963736 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04570492 0,07957707 ! peroxisomal transport GO:0043574 21 12 0,000 0,04570492 0,07951688 ! cartilage condensation GO:0001502 18 12 0,000 0,04570492 0,07945677 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04570492 0,07939676 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04570492 0,07933684 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04570492 0,07927701 ! heart looping GO:0001947 15 12 0,000 0,04570492 0,07921727 ! palate development GO:0060021 15 12 0,000 0,04570492 0,07915762 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04570492 0,07909805 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04570492 0,07903858 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04570492 0,0789792 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04570492 0,0789199 ! arginine metabolic process GO:0006525 13 12 0,000 0,04570492 0,0788607 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04570492 0,07880158 ! methionine metabolic process GO:0006555 13 12 0,000 0,04570492 0,07874256 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04570492 0,07868362 ! Golgi organization GO:0007030 18 12 0,000 0,04570492 0,07862477 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04570492 0,078566 ! monoamine transport GO:0015844 13 12 0,000 0,04570492 0,07850733 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04570492 0,07844874 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04570492 0,07839024 ! L-amino acid transport GO:0015807 20 12 0,000 0,04570492 0,07833183 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04570492 0,0782735 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04570492 0,07821526 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04570492 0,07815711 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04570492 0,07809904 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04570492 0,07804106 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04570492 0,07798317 ! cerebellum development GO:0021549 13 12 0,000 0,04570492 0,07792536 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04570492 0,07786764 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04570492 0,07781 ! histone methylation GO:0016571 15 12 0,000 0,04570492 0,07775245 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04570492 0,07769498 ! gland morphogenesis GO:0022612 23 12 0,000 0,04570492 0,0776376 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04570492 0,0775803 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04570492 0,07752309 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04570492 0,07746596 ! intestinal absorption GO:0050892 19 12 0,000 0,04570492 0,07740892 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04570492 0,07735196 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04570492 0,07729508 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04570492 0,07723829 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04570492 0,07718158 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,04570492 0,07712495 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04570492 0,07706841 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04570492 0,07701195 ! microspike assembly GO:0030035 23 12 0,000 0,04570492 0,07695557 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04570492 0,07689928 ! response to cold GO:0009409 14 12 0,000 0,04570492 0,07684306 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,04700937 0,07897849 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,04700937 0,07892084 ! regulation of T cell activation GO:0050863 128 89 1,000 0,04700937 0,07886327 ! leukocyte differentiation GO:0002521 143 90 1,000 0,04795971 0,08039894 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,0494194 0,0827856 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,0494194 0,08272535 ! cGMP metabolic process GO:0046068 16 13 0,000 0,0494194 0,08266519 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,0494194 0,08260511 ! water transport GO:0006833 17 13 0,000 0,0494194 0,08254512 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,0494194 0,08248522 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,0494194 0,0824254 ! lipid localization GO:0010876 24 13 0,000 0,0494194 0,08236567 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,0494194 0,08230603 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,0494194 0,08224648 ! organelle fusion GO:0048284 28 13 0,000 0,0494194 0,08218701 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,0494194 0,08212762 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,0494194 0,08206832 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,0494194 0,08200911 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,0494194 0,08194999 ! response to hexose stimulus GO:0009746 19 13 0,000 0,0494194 0,08189094 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,0494194 0,08183199 ! glutamate metabolic process GO:0006536 18 13 0,000 0,0494194 0,08177312 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,0494194 0,08171433 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,0494194 0,08165562 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,0494194 0,08159701 ! NAD metabolic process GO:0019674 21 13 0,000 0,0494194 0,08153847 ! exocrine system development GO:0035272 27 13 0,000 0,0494194 0,08148002 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,0494194 0,08142165 ! bone mineralization GO:0030282 15 13 0,000 0,0494194 0,08136337 ! regulation of exocytosis GO:0017157 17 13 0,000 0,0494194 0,08130517 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,0494194 0,08124706 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,0494194 0,08118902 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,0494194 0,08113107 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,0494194 0,0810732 ! genitalia development GO:0048806 15 13 0,000 0,0494194 0,08101542 ! cellular pigmentation GO:0033059 24 13 0,000 0,0494194 0,08095771 ! tissue regeneration GO:0042246 21 13 0,000 0,0494194 0,08090009 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,0494194 0,08084255 ! cofactor transport GO:0051181 19 13 0,000 0,0494194 0,0807851 ! NADP metabolic process GO:0006739 18 13 0,000 0,0494194 0,08072772 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,0494194 0,08067043 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,0494194 0,08061321 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0494194 0,08055608 ! gas transport GO:0015669 18 13 0,000 0,0494194 0,08049903 ! regulation of RNA stability GO:0043487 28 13 0,000 0,0494194 0,08044206 ! heme biosynthetic process GO:0006783 20 13 0,000 0,0494194 0,08038517 ! regulation of axon extension GO:0030516 23 13 0,000 0,0494194 0,08032836 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,0494194 0,08027163 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,0494194 0,08021498 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,0494194 0,08015841 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,0494194 0,08010192 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,0494194 0,08004551 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,0494194 0,07998918 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,04988143 0,08068022 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,04988143 0,08062353 ! DNA recombination GO:0006310 146 92 1,000 0,04988143 0,08056691 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,05085266 0,08207798 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05311964 0,08567684 ! superoxide anion generation GO:0042554 18 14 0,000 0,05311964 0,0856168 ! neuron maturation GO:0042551 21 14 0,000 0,05311964 0,08555685 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,05311964 0,08549698 ! myotube differentiation GO:0014902 21 14 0,000 0,05311964 0,08543719 ! inositol metabolic process GO:0006020 20 14 0,000 0,05311964 0,08537748 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05311964 0,08531786 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05311964 0,08525833 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05311964 0,08519887 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05311964 0,0851395 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05311964 0,08508021 ! response to cAMP GO:0051591 19 14 0,000 0,05311964 0,085021 ! limbic system development GO:0021761 25 14 0,000 0,05311964 0,08496188 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,05311964 0,08490284 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05311964 0,08484388 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05311964 0,084785 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,05311964 0,0847262 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05311964 0,08466748 ! glycine metabolic process GO:0006544 22 14 0,000 0,05311964 0,08460885 ! pituitary gland development GO:0021983 23 14 0,000 0,05311964 0,0845503 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,05311964 0,08449183 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,05311964 0,08443343 ! regulation of heart rate GO:0002027 23 14 0,000 0,05311964 0,08437512 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05311964 0,08431689 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,05311964 0,08425875 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05311964 0,08420068 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05311964 0,08414269 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,05311964 0,08408478 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05311964 0,08402695 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05311964 0,0839692 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05311964 0,08391152 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05311964 0,08385393 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05311964 0,08379642 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05311964 0,08373899 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05311964 0,08368163 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05311964 0,08362435 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05311964 0,08356715 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05311964 0,08351003 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05311964 0,08345299 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,05311964 0,08339603 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,05311964 0,08333914 ! muscle maintenance GO:0046716 19 14 0,000 0,05311964 0,08328233 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05311964 0,0832256 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05311964 0,08316895 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,05311964 0,08311237 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05311964 0,08305587 ! cell killing GO:0001906 20 14 0,000 0,05311964 0,08299944 ! cilium assembly GO:0042384 20 14 0,000 0,05311964 0,0829431 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05311964 0,08288683 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,05380709 0,08390257 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,05680569 0,08851835 ! positive regulation of cell size GO:0045793 20 15 0,000 0,05680569 0,08845842 ! metencephalon development GO:0022037 19 15 0,000 0,05680569 0,08839857 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,05680569 0,0883388 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,05680569 0,08827911 ! skin development GO:0043588 25 15 0,000 0,05680569 0,08821951 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,05680569 0,08815998 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,05680569 0,08810053 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,05680569 0,08804116 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,05680569 0,08798188 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,05680569 0,08792267 ! bile acid metabolic process GO:0008206 22 15 0,000 0,05680569 0,08786354 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,05680569 0,08780449 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,05680569 0,08774553 ! adult walking behavior GO:0007628 25 15 0,000 0,05680569 0,08768664 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,05680569 0,08762783 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,05680569 0,08756909 ! myoblast differentiation GO:0045445 27 15 0,000 0,05680569 0,08751044 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,05680569 0,08745187 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,05680569 0,08739337 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,05680569 0,08733495 ! cerebral cortex development GO:0021987 29 15 0,000 0,05680569 0,08727661 ! response to osmotic stress GO:0006970 22 15 0,000 0,05680569 0,08721835 ! vesicle coating GO:0006901 25 15 0,000 0,05680569 0,08716017 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,05680569 0,08710206 ! DNA integration GO:0015074 22 15 0,000 0,05680569 0,08704403 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,05680569 0,08698608 ! peptide secretion GO:0002790 27 15 0,000 0,05680569 0,0869282 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,05680569 0,0868704 ! regulation of vasodilation GO:0042312 24 15 0,000 0,05680569 0,08681268 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,05680569 0,08675504 ! neuron recognition GO:0008038 22 15 0,000 0,05680569 0,08669747 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,05680569 0,08663998 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,05680569 0,08658256 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,05680569 0,08652522 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,05680569 0,08646796 ! biomineral formation GO:0031214 18 15 0,000 0,05680569 0,08641077 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,05680569 0,08635366 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,05680569 0,08629662 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,05680569 0,08623966 ! dopamine metabolic process GO:0042417 30 15 0,000 0,05680569 0,08618278 ! organic cation transport GO:0015695 19 15 0,000 0,05680569 0,08612596 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,05680569 0,08606923 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,05680569 0,08601257 ! defense response to virus GO:0051607 27 15 0,000 0,05680569 0,08595598 ! peptide hormone processing GO:0016486 19 15 0,000 0,05680569 0,08589947 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,05680569 0,08584303 ! extracellular structure organization GO:0043062 156 99 1,000 0,05682121 0,08581011 ! protein import GO:0017038 156 99 1,000 0,05682121 0,0857538 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,05783889 0,08723242 ! protein localization in organelle GO:0033365 161 100 1,000 0,05783889 0,08717526 ! protein secretion GO:0009306 27 16 0,000 0,0604776 0,09109265 ! hormone secretion GO:0046879 25 16 0,000 0,0604776 0,09103303 ! bone remodeling GO:0046849 24 16 0,000 0,0604776 0,0909735 ! endothelial cell migration GO:0043542 22 16 0,000 0,0604776 0,09091404 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,0604776 0,09085465 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0604776 0,09079535 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,0604776 0,09073612 ! glial cell development GO:0021782 24 16 0,000 0,0604776 0,09067697 ! patterning of blood vessels GO:0001569 24 16 0,000 0,0604776 0,0906179 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,0604776 0,0905589 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,0604776 0,09049998 ! protein polyubiquitination GO:0000209 26 16 0,000 0,0604776 0,09044114 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,0604776 0,09038238 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,0604776 0,09032369 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,0604776 0,09026507 ! fructose metabolic process GO:0006000 20 16 0,000 0,0604776 0,09020653 ! regulation of protein binding GO:0043393 27 16 0,000 0,0604776 0,09014807 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,0604776 0,09008969 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,0604776 0,09003138 ! protein export from nucleus GO:0006611 24 16 0,000 0,0604776 0,08997314 ! negative regulation of immune response GO:0050777 28 16 0,000 0,0604776 0,08991498 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,0604776 0,0898569 ! DNA replication initiation GO:0006270 25 16 0,000 0,0604776 0,08979889 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,0604776 0,08974095 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,0604776 0,08968309 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,0604776 0,08962531 ! diencephalon development GO:0021536 25 16 0,000 0,0604776 0,0895676 ! neural crest cell migration GO:0001755 24 16 0,000 0,0604776 0,08950996 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,0604776 0,0894524 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,0604776 0,08939491 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,0604776 0,08933749 ! steroid catabolic process GO:0006706 22 16 0,000 0,0604776 0,08928015 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,0604776 0,08922288 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,0604776 0,08916569 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,0604776 0,08910857 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,0604776 0,08905152 ! sperm-egg recognition GO:0035036 16 16 0,000 0,0604776 0,08899455 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,0604776 0,08893764 ! nerve development GO:0021675 18 16 0,000 0,0604776 0,08888082 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,0604776 0,08882406 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,0604776 0,08876737 ! negative regulation of translation GO:0017148 22 16 0,000 0,0604776 0,08871076 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06413542 0,09401623 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06413542 0,09395635 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06413542 0,09389654 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06413542 0,09383681 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06413542 0,09377716 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06413542 0,09371758 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06413542 0,09365807 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06413542 0,09359865 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06413542 0,09353929 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,06413542 0,09348002 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06413542 0,09342082 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06413542 0,09336169 ! keratinization GO:0031424 17 17 0,000 0,06413542 0,09330264 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,06413542 0,09324366 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,06413542 0,09318475 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06413542 0,09312593 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,06413542 0,09306717 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,06413542 0,09300849 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06413542 0,09294988 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06413542 0,09289135 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,06413542 0,09283289 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06413542 0,09277451 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06413542 0,0927162 ! membrane budding GO:0006900 29 17 0,000 0,06413542 0,09265796 ! heme metabolic process GO:0042168 27 17 0,000 0,06413542 0,09259979 ! actin filament bundle formation GO:0051017 26 17 0,000 0,06413542 0,0925417 ! body fluid secretion GO:0007589 27 17 0,000 0,06413542 0,09248368 ! stem cell differentiation GO:0048863 36 17 0,000 0,06413542 0,09242573 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,06413542 0,09236786 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06413542 0,09231005 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06413542 0,09225232 ! sensory perception of pain GO:0019233 23 17 0,000 0,06413542 0,09219467 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06413542 0,09213708 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06413542 0,09207957 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,06413542 0,09202213 ! synaptogenesis GO:0007416 24 17 0,000 0,06413542 0,09196475 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,06413542 0,09190746 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06413542 0,09185023 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06413542 0,09179307 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06413542 0,09173599 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06413542 0,09167897 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06413542 0,09162203 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,06413542 0,09156516 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06413542 0,09150835 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06413542 0,09145162 ! positive regulation of translation GO:0045727 28 18 0,000 0,06777921 0,09658747 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,06777921 0,09652767 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,06777921 0,09646794 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,06777921 0,09640828 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,06777921 0,09634869 ! cAMP metabolic process GO:0046058 33 18 0,000 0,06777921 0,09628918 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,06777921 0,09622974 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,06777921 0,09617038 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,06777921 0,09611109 ! axis specification GO:0009798 26 18 0,000 0,06777921 0,09605187 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,06777921 0,09599272 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,06777921 0,09593365 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,06777921 0,09587465 ! glutamine metabolic process GO:0006541 23 18 0,000 0,06777921 0,09581572 ! response to retinoic acid GO:0032526 25 18 0,000 0,06777921 0,09575687 ! pigmentation during development GO:0048066 31 18 0,000 0,06777921 0,09569809 ! central nervous system neuron development GO:0021954 30 18 0,000 0,06777921 0,09563938 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,06777921 0,09558074 ! fucose metabolic process GO:0006004 26 18 0,000 0,06777921 0,09552217 ! response to fungus GO:0009620 19 18 0,000 0,06777921 0,09546368 ! peptide cross-linking GO:0018149 31 18 0,000 0,06777921 0,09540525 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,06777921 0,0953469 ! heart process GO:0003015 27 18 0,000 0,06777921 0,09528862 GO:0060047|heart contraction, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,06777921 0,09523041 ! visual learning GO:0008542 35 18 0,000 0,06777921 0,09517227 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,06777921 0,09511421 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,06777921 0,09505621 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,06777921 0,09499828 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,06777921 0,09494043 ! vitamin transport GO:0051180 24 18 0,000 0,06777921 0,09488264 ! hormone transport GO:0009914 27 18 0,000 0,06777921 0,09482493 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,06777921 0,09476728 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,06777921 0,09470971 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,06777921 0,09465221 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,06777921 0,09459477 ! cell-cell recognition GO:0009988 20 18 0,000 0,06777921 0,09453741 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,06777921 0,09448011 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,06777921 0,09442289 ! regulation of glucose import GO:0046324 21 18 0,000 0,06777921 0,09436573 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,06777921 0,09430864 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,06777921 0,09425162 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,07140902 0,09923912 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,07140902 0,0991792 ! positive regulation of ossification GO:0045778 30 19 0,000 0,07140902 0,09911934 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,07140902 0,09905956 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,07140902 0,09899985 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,07140902 0,09894021 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,07140902 0,09888064 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,07140902 0,09882115 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,07140902 0,09876172 ! regeneration GO:0031099 32 19 0,000 0,07140902 0,09870237 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,07140902 0,09864309 ! response to alkaloid GO:0043279 32 19 0,000 0,07140902 0,09858388 ! sensory perception of taste GO:0050909 23 19 0,000 0,07140902 0,09852474 ! smooth muscle contraction GO:0006939 36 19 0,000 0,07140902 0,09846568 ! peroxisome organization GO:0007031 29 19 0,000 0,07140902 0,09840668 ! digestive system process GO:0022600 30 19 0,000 0,07140902 0,09834775 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,07140902 0,0982889 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,07140902 0,09823011 ! response to vitamin A GO:0033189 26 19 0,000 0,07140902 0,0981714 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,07140902 0,09811275 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,07140902 0,09805418 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,07140902 0,09799567 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,07140902 0,09793724 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,07140902 0,09787887 ! plasma membrane fusion GO:0045026 23 19 0,000 0,07140902 0,09782058 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,07140902 0,09776235 ! cytolysis GO:0019835 20 19 0,000 0,07140902 0,09770419 ! renal system process GO:0003014 35 19 0,000 0,07140902 0,0976461 ! vasodilation GO:0042311 33 19 0,000 0,07140902 0,09758809 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,07140902 0,09753014 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,07140902 0,09747225 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,07140902 0,09741444 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,07140902 0,0973567 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,07140902 0,09729902 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,07140902 0,09724141 ! sarcomere organization GO:0045214 23 19 0,000 0,07140902 0,09718387 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,07140902 0,0971264 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,07140902 0,097069 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,07140902 0,09701166 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,07140902 0,0969544 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,07140902 0,0968972 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,07140902 0,09684006 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,07140902 0,096783 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,07502491 0,10162384 ! iron ion transport GO:0006826 37 20 0,000 0,07502491 0,10156403 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,07502491 0,10150428 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,07502491 0,10144461 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,07502491 0,10138501 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,07502491 0,10132547 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,07502491 0,10126601 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,07502491 0,10120662 ! spinal cord development GO:0021510 31 20 0,000 0,07502491 0,10114729 ! response to ethanol GO:0045471 37 20 0,000 0,07502491 0,10108804 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,07502491 0,10102885 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,07502491 0,10096974 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,07502491 0,10091069 ! chromosome condensation GO:0030261 31 20 0,000 0,07502491 0,10085171 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,07502491 0,1007928 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,07502491 0,10073397 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,07502491 0,10067519 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,07502491 0,10061649 ! pallium development GO:0021543 38 20 0,000 0,07502491 0,10055786 ! DNA modification GO:0006304 28 20 0,000 0,07502491 0,10049929 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,07502491 0,10044079 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,07502491 0,10038236 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,07502491 0,100324 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,07502491 0,10026571 ! collagen catabolic process GO:0030574 25 20 0,000 0,07502491 0,10020748 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,07502491 0,10014932 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,07502491 0,10009123 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,07502491 0,10003321 ! alditol metabolic process GO:0019400 24 20 0,000 0,07502491 0,09997525 ! actin filament-based movement GO:0030048 34 20 0,000 0,07502491 0,09991736 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,07862692 0,10465388 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,07862692 0,10459335 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,07862692 0,10453289 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,07862692 0,1044725 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,07862692 0,10441219 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,07862692 0,10435194 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,07862692 0,10429176 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,07862692 0,10423165 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,07862692 0,1041716 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,07862692 0,10411163 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,07862692 0,10405173 ! vesicle docking GO:0048278 27 21 0,000 0,07862692 0,1039919 ! phototransduction GO:0007602 25 21 0,000 0,07862692 0,10393213 ! dendrite development GO:0016358 35 21 0,000 0,07862692 0,10387243 ! visual behavior GO:0007632 39 21 0,000 0,07862692 0,1038128 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,07862692 0,10375325 ! ovarian follicle development GO:0001541 30 21 0,000 0,07862692 0,10369375 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,07862692 0,10363433 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,07862692 0,10357497 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,07862692 0,10351569 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,07862692 0,10345647 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,07862692 0,10339732 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,07862692 0,10333823 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,07862692 0,10327922 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,07862692 0,10322027 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,07862692 0,10316138 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,07862692 0,10310257 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,07862692 0,10304382 ! fatty acid transport GO:0015908 30 21 0,000 0,07862692 0,10298514 ! immunoglobulin production GO:0002377 33 21 0,000 0,07862692 0,10292653 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,07862692 0,10286798 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,07862692 0,1028095 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,07862692 0,10275108 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,07862692 0,10269273 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,07862692 0,10263445 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,07862692 0,10257624 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,07862692 0,10251809 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,07862692 0,10246 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,07862692 0,10240199 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,07862692 0,10234403 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,07862692 0,10228615 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,07862692 0,10222832 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,07862692 0,10217057 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,0822151 0,10677286 ! viral genome replication GO:0019079 29 22 0,000 0,0822151 0,10671261 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,0822151 0,10665242 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,0822151 0,1065923 ! molting cycle process GO:0022404 40 22 0,000 0,0822151 0,10653225 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,0822151 0,10647226 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,0822151 0,10641235 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,0822151 0,1063525 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,0822151 0,10629272 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,0822151 0,106233 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,0822151 0,10617335 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,0822151 0,10611377 ! lysosome organization GO:0007040 37 22 0,000 0,0822151 0,10605426 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,0822151 0,10599481 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,0822151 0,10593543 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,0822151 0,10587611 ! regulation of behavior GO:0050795 38 22 0,000 0,0822151 0,10581687 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,0822151 0,10575769 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,0822151 0,10569857 ! membrane depolarization GO:0051899 35 22 0,000 0,0822151 0,10563952 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,0822151 0,10558054 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,0822151 0,10552162 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,0822151 0,10546277 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,0822151 0,10540398 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,0822151 0,10534526 ! neural tube closure GO:0001843 33 22 0,000 0,0822151 0,1052866 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,0822151 0,10522801 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,08578952 0,10974188 ! neuron fate commitment GO:0048663 32 23 0,000 0,08578952 0,10968088 ! embryonic pattern specification GO:0009880 31 23 0,000 0,08578952 0,10961995 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,08578952 0,10955908 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,08578952 0,10949828 ! vesicle targeting GO:0006903 32 23 0,000 0,08578952 0,10943755 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,08578952 0,10937689 ! osteoblast differentiation GO:0001649 40 23 0,000 0,08578952 0,10931629 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,08578952 0,10925576 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,08578952 0,1091953 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,08578952 0,1091349 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,08578952 0,10907458 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,08578952 0,10901431 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,08578952 0,10895412 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,08578952 0,10889399 ! cell fate determination GO:0001709 45 23 0,000 0,08578952 0,10883393 ! pentose metabolic process GO:0019321 31 23 0,000 0,08578952 0,10877393 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,08578952 0,108714 ! spermatid development GO:0007286 33 23 0,000 0,08578952 0,10865413 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,08578952 0,10859434 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,08578952 0,1085346 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,08578952 0,10847494 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,08578952 0,10841533 ! telomere organization GO:0032200 32 23 0,000 0,08578952 0,1083558 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,08578952 0,10829633 ! regulation of amine transport GO:0051952 38 23 0,000 0,08578952 0,10823692 ! liver development GO:0001889 40 23 0,000 0,08578952 0,10817758 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,08935023 0,11260577 ! initiation of viral infection GO:0019059 42 24 0,000 0,08935023 0,1125441 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,08935023 0,1124825 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,08935023 0,11242096 ! superoxide metabolic process GO:0006801 32 24 0,000 0,08935023 0,1123595 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,08935023 0,1122981 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,08935023 0,11223677 ! fat cell differentiation GO:0045444 37 24 0,000 0,08935023 0,1121755 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,08935023 0,11211431 ! sperm motility GO:0030317 27 24 0,000 0,08935023 0,11205318 ! vacuole organization GO:0007033 39 24 0,000 0,08935023 0,11199211 ! neural crest cell development GO:0014032 39 24 0,000 0,08935023 0,11193111 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,08935023 0,11187018 ! primary neural tube formation GO:0014020 35 24 0,000 0,08935023 0,11180932 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,08935023 0,11174852 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,08935023 0,11168778 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,08935023 0,11162712 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,08935023 0,11156652 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,08935023 0,11150598 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,08935023 0,11144551 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,09289727 0,11580689 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,09289727 0,11574416 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,09289727 0,11568149 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,09289727 0,11561889 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,09289727 0,11555636 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,09289727 0,1154939 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,09289727 0,1154315 ! peptide transport GO:0015833 43 25 0,000 0,09289727 0,11536917 ! male gonad development GO:0008584 33 25 0,000 0,09289727 0,11530691 ! iron ion homeostasis GO:0055072 39 25 0,000 0,09289727 0,11524472 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,09289727 0,11518259 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,09289727 0,11512053 ! phospholipid transport GO:0015914 35 25 0,000 0,09289727 0,11505854 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,09289727 0,11499661 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,09289727 0,11493476 ! detection of light stimulus GO:0009583 30 25 0,000 0,09289727 0,11487296 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,09289727 0,11481124 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,09289727 0,11474958 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,09643069 0,11905023 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,09643069 0,11898637 ! translational initiation GO:0006413 43 26 0,000 0,09643069 0,11892257 ! circadian rhythm GO:0007623 42 26 0,000 0,09643069 0,11885883 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,09643069 0,11879517 ! post-embryonic development GO:0009791 42 26 0,000 0,09643069 0,11873158 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,09643069 0,11866805 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,09643069 0,11860459 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,09643069 0,1185412 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,09643069 0,11847788 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,09643069 0,11841462 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,09643069 0,11835143 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,09643069 0,11828831 ! regulation of coagulation GO:0050818 39 26 0,000 0,09643069 0,11822526 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,09995055 0,12247537 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,09995055 0,12241015 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,09995055 0,12234501 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,09995055 0,12227993 ! membrane docking GO:0022406 39 27 0,000 0,09995055 0,12221492 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,09995055 0,12214998 ! catechol metabolic process GO:0009712 43 27 0,000 0,09995055 0,12208511 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,09995055 0,12202031 ! acute-phase response GO:0006953 42 27 0,000 0,09995055 0,12195558 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,09995055 0,12189092 ! myofibril assembly GO:0030239 36 27 0,000 0,09995055 0,12182632 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,09995055 0,1217618 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,09995055 0,12169734 ! natural killer cell activation GO:0030101 35 27 0,000 0,09995055 0,12163295 ! lipid oxidation GO:0034440 38 27 0,000 0,09995055 0,12156862 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,09995055 0,12150437 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,09995055 0,12144018 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,09995055 0,12137607 ! gene silencing GO:0016458 41 27 0,000 0,09995055 0,12131202 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,1034569 0,12550152 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,1034569 0,12543536 ! phenol metabolic process GO:0018958 44 28 0,000 0,1034569 0,12536927 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,1034569 0,12530325 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,1034569 0,1252373 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,1034569 0,12517142 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,1034569 0,12510561 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,1034569 0,12503987 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,1034569 0,1249742 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,1034569 0,1249086 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,1034569 0,12484306 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,1034569 0,1247776 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,1034569 0,1247122 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,1034569 0,12464687 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,1034569 0,12458161 ! mesoderm formation GO:0001707 46 28 0,000 0,1034569 0,12451642 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,1034569 0,1244513 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,1034569 0,12438624 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,1034569 0,12432125 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,1034569 0,12425633 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,1034569 0,12419148 ! neural tube formation GO:0001841 41 28 0,000 0,1034569 0,1241267 ! placenta development GO:0001890 37 28 0,000 0,1034569 0,12406198 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,10694979 0,1281837 ! regulation of innate immune response GO:0045088 38 29 0,000 0,10694979 0,12811694 ! ovulation cycle process GO:0022602 41 29 0,000 0,10694979 0,12805025 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,10694979 0,12798363 ! protein targeting to membrane GO:0006612 53 29 0,000 0,10694979 0,12791707 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,10694979 0,12785059 ! mismatch repair GO:0006298 34 29 0,000 0,10694979 0,12778417 ! muscle cell development GO:0055001 38 29 0,000 0,10694979 0,12771782 ! formation of primary germ layer GO:0001704 48 29 0,000 0,10694979 0,12765155 ! telencephalon development GO:0021537 52 29 0,000 0,10694979 0,12758534 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,10694979 0,1275192 ! eye morphogenesis GO:0048592 51 29 0,000 0,10694979 0,12745312 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,10694979 0,12738712 ! tissue homeostasis GO:0001894 42 29 0,000 0,10694979 0,12732118 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,11042928 0,13139542 ! collagen metabolic process GO:0032963 40 30 0,000 0,11042928 0,13132748 ! organic anion transport GO:0015711 51 30 0,000 0,11042928 0,13125961 ! cholesterol transport GO:0030301 46 30 0,000 0,11042928 0,13119181 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,11042928 0,13112408 ! spliceosome assembly GO:0000245 49 30 0,000 0,11042928 0,13105642 ! spindle organization GO:0007051 37 30 0,000 0,11042928 0,13098883 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,11042928 0,13092131 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,11042928 0,13085386 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,11042928 0,13078648 ! ceramide metabolic process GO:0006672 43 30 0,000 0,11042928 0,13071917 ! ovulation cycle GO:0042698 43 30 0,000 0,11042928 0,13065192 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,11042928 0,13058475 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,11042928 0,13051765 ! response to heat GO:0009408 41 30 0,000 0,11042928 0,13045061 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,11042928 0,13038364 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,11042928 0,13031675 ! glial cell differentiation GO:0010001 55 31 0,000 0,1138954 0,13433817 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,1138954 0,13426931 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,1138954 0,13420053 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,1138954 0,13413181 ! odontogenesis GO:0042476 50 31 0,000 0,1138954 0,13406317 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,1138954 0,13399459 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,1138954 0,13392609 ! metanephros development GO:0001656 58 31 0,000 0,1138954 0,13385765 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,1138954 0,13378929 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,1138954 0,13372099 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,1138954 0,13365277 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,1138954 0,13358461 ! RNA modification GO:0009451 40 31 0,000 0,1138954 0,13351653 ! regulation of muscle development GO:0048634 48 32 0,000 0,11734822 0,13749409 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,11734822 0,13742409 ! meiosis I GO:0007127 52 32 0,000 0,11734822 0,13735415 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,11734822 0,13728429 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,11734822 0,13721449 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,11734822 0,13714477 ! cytokine production GO:0001816 44 32 0,000 0,11734822 0,13707512 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,11734822 0,13700554 ! vesicle localization GO:0051648 47 32 0,000 0,11734822 0,13693602 ! RNA export from nucleus GO:0006405 44 33 0,000 0,12078778 0,14087824 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,12078778 0,14080684 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,12078778 0,14073551 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,12078778 0,14066425 ! sister chromatid segregation GO:0000819 46 33 0,000 0,12078778 0,14059306 ! ear morphogenesis GO:0042471 42 33 0,000 0,12078778 0,14052195 ! actomyosin structure organization GO:0031032 43 33 0,000 0,12078778 0,14045091 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,12078778 0,14037994 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,12078778 0,14030904 ! nucleus organization GO:0006997 49 33 0,000 0,12078778 0,14023821 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,12078778 0,14016745 ! positive regulation of cell development GO:0010720 54 33 0,000 0,12078778 0,14009677 ! lipid homeostasis GO:0055088 55 33 0,000 0,12078778 0,14002616 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,12078778 0,13995561 ! regulation of proteolysis GO:0030162 50 33 0,000 0,12078778 0,13988514 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,12078778 0,13981474 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,12078778 0,13974441 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,12421413 0,14363625 ! mRNA catabolic process GO:0006402 48 34 0,000 0,12421413 0,14356407 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,12421413 0,14349197 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,12421413 0,14341993 ! feeding behavior GO:0007631 45 34 0,000 0,12421413 0,14334797 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,12421413 0,14327608 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,12421413 0,14320426 ! neuron migration GO:0001764 46 34 0,000 0,12421413 0,14313252 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,12421413 0,14306084 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,12421413 0,14298924 ! polyol metabolic process GO:0019751 44 34 0,000 0,12421413 0,14291771 ! aerobic respiration GO:0009060 47 34 0,000 0,12421413 0,14284625 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,12421413 0,14277486 ! embryonic organ development GO:0048568 45 34 0,000 0,12421413 0,14270355 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,12421413 0,1426323 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,12762733 0,14647847 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,12762733 0,14640541 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,12762733 0,14633243 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,12762733 0,14625952 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,12762733 0,14618668 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,12762733 0,14611391 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,12762733 0,14604122 ! glycogen metabolic process GO:0005977 48 35 0,000 0,12762733 0,1459686 ! pigment metabolic process GO:0042440 61 35 0,000 0,12762733 0,14589605 ! protein homooligomerization GO:0051260 52 35 0,000 0,12762733 0,14582357 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,13102742 0,14963409 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,13102742 0,14955983 ! tissue remodeling GO:0048771 62 36 0,000 0,13102742 0,14948564 ! neural tube development GO:0021915 50 36 0,000 0,13102742 0,14941153 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,13102742 0,14933749 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,13102742 0,14926353 ! glucan metabolic process GO:0044042 49 36 0,000 0,13102742 0,14918963 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,13441445 0,15297042 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,13441445 0,15289477 ! learning GO:0007612 67 37 0,000 0,13441445 0,15281919 ! ion transmembrane transport GO:0034220 56 37 0,000 0,13441445 0,15274369 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,13441445 0,15266826 ! regulation of protein secretion GO:0050708 51 37 0,000 0,13441445 0,15259291 ! amino acid activation GO:0043038 52 37 0,000 0,13441445 0,15251763 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,13441445 0,15244242 ! gliogenesis GO:0042063 71 38 0,000 0,13778847 0,15619196 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,13778847 0,15611501 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,13778847 0,15603815 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,13778847 0,15596136 ! phagocytosis GO:0006909 60 38 0,000 0,13778847 0,15588464 ! pigmentation GO:0043473 74 38 0,000 0,13778847 0,155808 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,14114953 0,15953018 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,14114953 0,15945183 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,14114953 0,15937355 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,14114953 0,15929535 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,14114953 0,15921723 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,14114953 0,15913918 ! male sex differentiation GO:0046661 53 39 0,000 0,14114953 0,15906121 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,14114953 0,15898331 ! chromatin remodeling GO:0006338 68 39 0,000 0,14114953 0,15890549 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,14114953 0,15882775 ! JNK cascade GO:0007254 54 39 0,000 0,14114953 0,15875009 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,14449769 0,1624363 ! response to calcium ion GO:0051592 58 40 0,000 0,14449769 0,16235695 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,14449769 0,16227767 ! regulation of tube size GO:0035150 60 40 0,000 0,14449769 0,16219848 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,14449769 0,16211935 ! peptide metabolic process GO:0006518 56 40 0,000 0,14449769 0,16204031 ! inner ear development GO:0048839 57 40 0,000 0,14449769 0,16196134 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,14449769 0,16188245 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,14449769 0,16180364 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,14449769 0,1617249 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,14449769 0,16164624 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,14783298 0,16529696 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,14783298 0,16521664 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,14783298 0,1651364 ! glucose transport GO:0015758 52 41 0,000 0,14783298 0,16505624 ! striated muscle contraction GO:0006941 62 41 0,000 0,14783298 0,16497615 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,14783298 0,16489614 ! biopolymer methylation GO:0043414 62 41 0,000 0,14783298 0,16481621 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,14783298 0,16473636 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,15115546 0,16835717 ! cellular component disassembly GO:0022411 64 42 0,000 0,15115546 0,16827568 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,15115546 0,16819427 ! hexose transport GO:0008645 54 42 0,000 0,15115546 0,16811293 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,15115546 0,16803168 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,15115546 0,16795051 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,15115546 0,16786941 ! excretion GO:0007588 63 42 0,000 0,15115546 0,16778839 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,15115546 0,16770745 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,15115546 0,16762659 ! regulation of cell shape GO:0008360 78 42 0,000 0,15115546 0,16754581 ! leukocyte migration GO:0050900 60 43 0,000 0,15446517 0,17113193 ! tRNA processing GO:0008033 49 43 0,000 0,15446517 0,17104954 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,15446517 0,17096722 ! vesicle organization GO:0016050 79 43 0,000 0,15446517 0,17088499 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,15446517 0,17080283 ! methylation GO:0032259 64 43 0,000 0,15446517 0,17072076 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,15776217 0,17428098 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,15776217 0,17419731 ! glycolysis GO:0006096 53 44 0,000 0,15776217 0,17411372 ! regulation of ion transport GO:0043269 57 44 0,000 0,15776217 0,17403021 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,15776217 0,17394678 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,15776217 0,17386344 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,15776217 0,17378017 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,15776217 0,17369698 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,15776217 0,17361387 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,15776217 0,17353084 ! RNA catabolic process GO:0006401 64 45 0,000 0,1610465 0,17705877 ! regulation of translational initiation GO:0006446 64 45 0,000 0,1610465 0,17697418 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,1610465 0,17688966 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,1610465 0,17680523 ! cell recognition GO:0008037 58 45 0,000 0,1610465 0,17672087 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,16431821 0,18022503 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,16431821 0,18013913 ! cell redox homeostasis GO:0045454 63 46 0,000 0,16431821 0,18005331 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,16431821 0,17996757 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,16757735 0,18344974 ! viral infectious cycle GO:0019058 71 47 0,000 0,16757735 0,18336247 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,16757735 0,18327528 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,16757735 0,18318817 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,16757735 0,18310115 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,16757735 0,1830142 ! chloride transport GO:0006821 67 48 0,000 0,17082397 0,18647135 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,17082397 0,18638289 ! response to temperature stimulus GO:0009266 62 48 0,000 0,17082397 0,18629451 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,17082397 0,18620622 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,17082397 0,18611801 ! gastrulation GO:0007369 73 48 0,000 0,17082397 0,18602989 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,17082397 0,18594185 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,17082397 0,18585389 ! regulation of endocytosis GO:0030100 63 48 0,000 0,17082397 0,18576602 ! nuclear export GO:0051168 69 48 0,000 0,17082397 0,18567823 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,17082397 0,18559052 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,17405811 0,18901494 ! sensory perception of smell GO:0007608 61 49 0,000 0,17405811 0,18892574 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,17405811 0,18883663 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,17405811 0,18874759 ! RNA elongation GO:0006354 62 49 0,000 0,17405811 0,18865865 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,17405811 0,18856978 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,17405811 0,188481 ! cartilage development GO:0051216 70 49 0,000 0,17405811 0,1883923 ! regulation of actin filament length GO:0030832 72 50 0,000 0,17727982 0,19178908 ! ear development GO:0043583 72 50 0,000 0,17727982 0,19169891 ! membrane fusion GO:0006944 80 50 0,000 0,17727982 0,19160882 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,17727982 0,19151882 ! proton transport GO:0015992 75 50 0,000 0,17727982 0,19142891 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,17727982 0,19133908 ! hydrogen transport GO:0006818 77 51 0,000 0,18048914 0,19471155 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,18048914 0,19462027 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,18048914 0,19452907 ! transition metal ion transport GO:0000041 74 52 0,000 0,18368613 0,19788202 ! regulation of cellular component size GO:0032535 74 52 0,000 0,18368613 0,19778937 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,18368613 0,19769682 ! establishment of organelle localization GO:0051656 85 52 0,000 0,18368613 0,19760435 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,18687083 0,20093638 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,18687083 0,20084248 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,18687083 0,20074868 ! kidney development GO:0001822 90 53 0,000 0,18687083 0,20065496 ! single fertilization GO:0007338 59 53 0,000 0,18687083 0,20056132 ! cell projection assembly GO:0030031 76 53 0,000 0,18687083 0,20046778 ! amino acid transport GO:0006865 84 54 0,000 0,19004329 0,20377602 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,19004329 0,20368107 ! regulation of mitosis GO:0007088 84 54 0,000 0,19004329 0,2035862 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,19004329 0,20349142 ! DNA catabolic process GO:0006308 67 54 0,000 0,19004329 0,20339673 ! detection of external stimulus GO:0009581 66 54 0,000 0,19004329 0,20330213 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,19004329 0,20320761 ! exocytosis GO:0006887 74 55 0,000 0,19320355 0,20649079 ! mesoderm development GO:0007498 76 55 0,000 0,19320355 0,20639488 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,19320355 0,20629906 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,19320355 0,20620333 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,19635167 0,20946606 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,19635167 0,20936895 ! carbohydrate transport GO:0008643 74 57 0,000 0,19948768 0,2126143 ! chromosome segregation GO:0007059 83 57 0,000 0,19948768 0,21251582 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,19948768 0,21241743 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,19948768 0,21231914 ! camera-type eye development GO:0043010 88 57 0,000 0,19948768 0,21222093 ! secondary metabolic process GO:0019748 84 57 0,000 0,19948768 0,21212282 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,20261163 0,21534507 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,20261163 0,21524561 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,20572356 0,21845069 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,20572356 0,21834988 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,20572356 0,21824917 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,20882354 0,22143575 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,20882354 0,2213337 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,20882354 0,22123175 ! regulation of heart contraction GO:0008016 91 60 0,000 0,20882354 0,2211299 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,20882354 0,22102813 ! fertilization GO:0009566 68 60 0,000 0,20882354 0,22092646 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,20882354 0,22082489 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,21191159 0,22398743 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,21191159 0,22388454 ! urogenital system development GO:0001655 101 61 0,000 0,21191159 0,22378175 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,21191159 0,22367905 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,21191159 0,22357644 ! extracellular matrix organization GO:0030198 103 61 0,000 0,21191159 0,22347393 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,21191159 0,22337152 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,21191159 0,22326919 ! amine catabolic process GO:0009310 90 62 0,000 0,21498776 0,22640652 ! neurotransmitter transport GO:0006836 81 62 0,000 0,21498776 0,2263029 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,21498776 0,22619938 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,21498776 0,22609595 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,21498776 0,22599262 ! organelle localization GO:0051640 96 62 0,000 0,21498776 0,22588938 ! appendage morphogenesis GO:0035107 93 64 0,000 0,22110466 0,23221037 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,22110466 0,23210438 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,22110466 0,2319985 ! hexose catabolic process GO:0019320 82 64 0,000 0,22110466 0,23189271 ! adaptive immune response GO:0002250 94 64 0,000 0,22110466 0,23178701 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,22414547 0,23486769 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,22414547 0,23476074 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,22414547 0,23465388 ! defense response to bacterium GO:0042742 73 65 0,000 0,22414547 0,23454712 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,22414547 0,23444046 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,22414547 0,2343339 ! activation of immune response GO:0002253 83 65 0,000 0,22414547 0,23422743 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,22717458 0,23728499 ! antigen processing and presentation GO:0019882 96 66 0,000 0,22717458 0,23717728 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,22717458 0,23706967 ! regulation of immune effector process GO:0002697 101 66 0,000 0,22717458 0,23696215 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,23019205 0,24000077 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,23019205 0,23989203 ! acute inflammatory response GO:0002526 92 68 0,000 0,2331979 0,24291448 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,2331979 0,24280451 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,2331979 0,24269465 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,2331979 0,24258488 ! rhythmic process GO:0048511 105 68 0,000 0,2331979 0,24247521 ! inorganic anion transport GO:0015698 93 68 0,000 0,2331979 0,24236564 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,23619219 0,24536677 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,23619219 0,245256 ! response to metal ion GO:0010038 103 70 0,000 0,23917496 0,24824116 ! humoral immune response GO:0006959 86 70 0,000 0,23917496 0,24812918 ! eye development GO:0001654 111 70 0,000 0,23917496 0,24801731 ! amine transport GO:0015837 101 70 0,000 0,23917496 0,24790554 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,23917496 0,24779387 ! muscle cell differentiation GO:0042692 104 71 0,000 0,24214625 0,25075928 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,24214625 0,25064643 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,24214625 0,25053368 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,24214625 0,25042103 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,24214625 0,25030848 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,2451061 0,25325428 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,2451061 0,25314056 ! regulation of blood pressure GO:0008217 107 73 0,000 0,24805457 0,25607069 ! tube morphogenesis GO:0035239 118 73 0,000 0,24805457 0,25595581 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,24805457 0,25584103 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,25099169 0,25875432 ! digestion GO:0007586 97 74 0,000 0,25099169 0,25863839 ! blood coagulation GO:0007596 116 75 0,000 0,2539175 0,26153616 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,2539175 0,26141909 ! regulation of ligase activity GO:0051340 114 75 0,000 0,2539175 0,26130213 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,2539175 0,26118526 ! amine biosynthetic process GO:0009309 97 76 0,000 0,25683205 0,26406514 ! tRNA metabolic process GO:0006399 95 76 0,000 0,25683205 0,26394715 ! response to unfolded protein GO:0006986 99 76 0,000 0,25683205 0,26382926 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,25683205 0,26371148 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,25973539 0,26657358 ! protein ubiquitination GO:0016567 125 77 0,000 0,25973539 0,26645468 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,25973539 0,26633588 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,25973539 0,2662172 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,25973539 0,26609861 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,26262754 0,26894183 ! cellular respiration GO:0045333 107 79 0,000 0,26550857 0,27177112 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,26550857 0,27165022 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,26550857 0,27152944 ! chromatin assembly GO:0031497 102 80 0,000 0,2683785 0,27434246 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,2683785 0,27422059 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,2683785 0,27409882 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,2683785 0,27397716 ! forebrain development GO:0030900 131 80 0,000 0,2683785 0,27385561 ! hemostasis GO:0007599 125 81 0,000 0,27123738 0,2766501 ! mRNA transport GO:0051028 121 81 0,000 0,27123738 0,27652747 ! response to protein stimulus GO:0051789 111 81 0,000 0,27123738 0,27640495 ! vitamin metabolic process GO:0006766 103 81 0,000 0,27123738 0,27628254 ! detection of stimulus GO:0051606 108 82 0,000 0,27408525 0,2790598 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,27692216 0,28182344 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,27974815 0,28457352 ! sterol metabolic process GO:0016125 120 84 0,000 0,27974815 0,28444772 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,28256325 0,28718315 ! rRNA metabolic process GO:0016072 107 85 0,000 0,28256325 0,2870563 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,28256325 0,28692957 ! nucleosome organization GO:0034728 114 87 0,000 0,28816096 0,29248465 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,28816096 0,29235563 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,28816096 0,29222673 ! female pregnancy GO:0007565 130 87 0,000 0,28816096 0,29209794 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,29094366 0,29478873 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,29094366 0,29465893 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,29094366 0,29452924 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,29094366 0,29439966 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,29094366 0,2942702 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,29371564 0,29694329 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,29647695 0,29960324 ! RNA localization GO:0006403 135 91 0,000 0,29922761 0,30225011 ! ATP metabolic process GO:0046034 137 91 0,000 0,29922761 0,30211743 ! response to virus GO:0009615 122 91 0,000 0,29922761 0,30198487 ! positive regulation of immune response GO:0050778 121 92 0,000 0,30196768 0,30461652 ! sulfur metabolic process GO:0006790 118 92 0,000 0,30196768 0,30448297 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,30469719 0,30710059 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,30469719 0,30696607 ! electron transport chain GO:0022900 123 94 0,000 0,30741619 0,30956971 ! response to oxidative stress GO:0006979 141 94 0,000 0,30741619 0,30943423 ! angiogenesis GO:0001525 149 95 0,000 0,3101247 0,31202398 ! carboxylic acid transport GO:0046942 147 95 0,000 0,3101247 0,31188755 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,31282278 0,31446346 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,31282278 0,31432608 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,31282278 0,31418882 ! protein maturation GO:0051604 129 96 0,000 0,31282278 0,31405168 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,31551047 0,31661172 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,3208548 0,32183429 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,3208548 0,321694 ! regulation of translation GO:0006417 151 100 0,000 0,32351152 0,32421634 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,32351152 0,32407513 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,32351152 0,32393405 ! divalent metal ion transport GO:0070838 171 100 0,000 0,32351152 0,32379308 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,32351152 0,32365224 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,32351152 0,32351152