pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6481-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 1,227E-08 2,823E-05 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 2,193E-07 2,521E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 3,316E-07 2,542E-04 ! activation of MAPKKK activity GO:0000185 10 6 2,000 4,376E-07 2,516E-04 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 4,376E-07 2,013E-04 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 7,643E-07 2,93E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,22E-06 4,01E-04 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 1,22E-06 3,509E-04 ! regulation of protein stability GO:0031647 48 32 3,000 2,007E-06 5,128E-04 ! response to nutrient GO:0007584 104 75 4,000 2,314E-06 5,322E-04 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 2,000 2,605E-06 5,446E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 4,523E-06 8,669E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 5,015E-06 8,872E-04 ! copper ion transport GO:0006825 15 13 2,000 6,17E-06 1,014E-03 ! angiogenesis GO:0001525 149 95 4,000 7,441E-06 1,141E-03 ! inositol metabolic process GO:0006020 20 14 2,000 7,837E-06 1,127E-03 ! activation of MAPKK activity GO:0000186 21 14 2,000 7,837E-06 1,06E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 8,09E-06 1,034E-03 ! response to UV GO:0009411 75 46 3,000 8,842E-06 1,07E-03 ! cardiac muscle tissue development GO:0048738 23 15 2,000 9,777E-06 1,124E-03 ! endothelial cell migration GO:0043542 22 16 2,000 1,201E-05 1,315E-03 ! cellular response to hydrogen peroxide GO:0070301 21 16 2,000 1,201E-05 1,255E-03 GO:0042744|hydrogen peroxide catabolic process, ! lipid modification GO:0030258 73 50 3,000 1,237E-05 1,237E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,34E-05 1,284E-03 ! aging GO:0007568 79 52 3,000 1,449E-05 1,333E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1,455E-05 1,287E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 1,949E-05 1,66E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 2,065E-05 1,697E-03 ! cellular response to reactive oxygen species GO:0034614 27 19 2,000 2,065E-05 1,638E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 2,091E-05 1,603E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 2,242E-05 1,663E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 2,425E-05 1,743E-03 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 2,566E-05 1,788E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 2,74E-05 1,853E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 3,263E-05 2,144E-03 GO:0010810|regulation of cell-substrate adhesion, ! cellular iron ion homeostasis GO:0006879 37 23 2,000 3,745E-05 2,392E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 3,745E-05 2,328E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 3,745E-05 2,266E-03 ! hydrogen peroxide metabolic process GO:0042743 30 23 2,000 3,745E-05 2,208E-03 ! cellular response to oxidative stress GO:0034599 33 23 2,000 3,745E-05 2,153E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 4,271E-05 2,396E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 4,271E-05 2,339E-03 ! regulation of catabolic process GO:0009894 106 70 3,000 4,724E-05 2,527E-03 ! iron ion homeostasis GO:0055072 39 25 2,000 4,844E-05 2,532E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 4,844E-05 2,476E-03 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 5,464E-05 2,732E-03 ! negative regulation of protein transport GO:0051224 49 27 2,000 6,135E-05 3,002E-03 ! positive regulation of catabolic process GO:0009896 40 28 2,000 6,857E-05 3,286E-03 ! response to hydrogen peroxide GO:0042542 42 29 2,000 7,633E-05 3,583E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 7,973E-05 3,668E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 7,973E-05 3,596E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 7,973E-05 3,527E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 7,973E-05 3,46E-03 ! centrosome duplication GO:0051298 5 5 1,000 7,973E-05 3,396E-03 ! response to UV-C GO:0010225 6 5 1,000 7,973E-05 3,334E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 7,973E-05 3,275E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 7,973E-05 3,217E-03 ! regulation of cell adhesion GO:0030155 159 83 3,000 9,212E-05 3,653E-03 ! mammary gland development GO:0030879 57 31 2,000 9,352E-05 3,646E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 1,011E-04 3,875E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 1,058E-04 3,989E-03 ! negative regulation of cell adhesion GO:0007162 67 33 2,000 1,131E-04 4,194E-03 ! interphase GO:0051325 159 88 3,000 1,157E-04 4,223E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 1,194E-04 4,29E-03 ! male meiosis GO:0007140 7 6 1,000 1,194E-04 4,224E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,194E-04 4,16E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,194E-04 4,098E-03 ! mRNA stabilization GO:0048255 15 6 1,000 1,194E-04 4,038E-03 GO:0043489|RNA stabilization, ! male sex determination GO:0030238 9 6 1,000 1,194E-04 3,979E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 1,194E-04 3,922E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! blastocyst growth GO:0001832 15 6 1,000 1,194E-04 3,867E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 1,194E-04 3,813E-03 ! polyol metabolic process GO:0019751 44 34 2,000 1,238E-04 3,899E-03 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,238E-04 3,846E-03 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,351E-04 4,143E-03 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 1,374E-04 4,16E-03 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 1,433E-04 4,281E-03 ! response to reactive oxygen species GO:0000302 55 36 2,000 1,471E-04 4,337E-03 ! response to light stimulus GO:0009416 153 96 3,000 1,62E-04 4,718E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,668E-04 4,796E-03 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,668E-04 4,737E-03 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,668E-04 4,679E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 1,668E-04 4,623E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 2,22E-04 6,079E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,22E-04 6,008E-03 ! induction of positive chemotaxis GO:0050930 14 8 1,000 2,22E-04 5,938E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,22E-04 5,87E-03 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 2,22E-04 5,803E-03 ! multicellular organism growth GO:0035264 14 8 1,000 2,22E-04 5,738E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,22E-04 5,674E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 2,22E-04 5,612E-03 ! S phase GO:0051320 8 8 1,000 2,22E-04 5,551E-03 GO:0000084|S phase of mitotic cell cycle, ! regulation of embryonic development GO:0045995 16 8 1,000 2,22E-04 5,491E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 2,22E-04 5,432E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 2,336E-04 5,656E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 2,506E-04 6,005E-03 ! response to insulin stimulus GO:0032868 63 43 2,000 2,506E-04 5,943E-03 ! negative regulation of cell migration GO:0030336 92 44 2,000 2,684E-04 6,3E-03 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,684E-04 6,236E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 2,849E-04 6,553E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,849E-04 6,489E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 2,849E-04 6,425E-03 ! lung alveolus development GO:0048286 17 9 1,000 2,849E-04 6,363E-03 ! receptor clustering GO:0043113 15 9 1,000 2,849E-04 6,301E-03 ! motor axon guidance GO:0008045 14 9 1,000 2,849E-04 6,241E-03 ! oocyte differentiation GO:0009994 12 9 1,000 2,849E-04 6,183E-03 GO:0048599|oocyte development, ! localization within membrane GO:0051668 15 9 1,000 2,849E-04 6,125E-03 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,87E-04 6,113E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 3,267E-04 6,893E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA replication GO:0006275 75 48 2,000 3,478E-04 7,271E-03 ! regulation of B cell proliferation GO:0030888 15 10 1,000 3,555E-04 7,367E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 3,555E-04 7,301E-03 ! blood vessel remodeling GO:0001974 21 10 1,000 3,555E-04 7,236E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 3,555E-04 7,173E-03 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 3,555E-04 7,11E-03 ! response to X-ray GO:0010165 16 10 1,000 3,555E-04 7,049E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 3,555E-04 6,989E-03 ! regulation of bone resorption GO:0045124 24 10 1,000 3,555E-04 6,93E-03 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 3,555E-04 6,871E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 3,555E-04 6,814E-03 GO:0043470|regulation of carbohydrate catabolic process, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 3,555E-04 6,758E-03 ! regulation of intracellular transport GO:0032386 78 49 2,000 3,697E-04 6,97E-03 ! regulation of protein catabolic process GO:0042176 77 51 2,000 4,162E-04 7,783E-03 ! negative regulation of cell motion GO:0051271 104 51 2,000 4,162E-04 7,72E-03 ! virus-host interaction GO:0019048 17 11 1,000 4,337E-04 7,981E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,337E-04 7,917E-03 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 4,337E-04 7,855E-03 GO:0000725|recombinational repair, ! regulation of positive chemotaxis GO:0050926 17 11 1,000 4,337E-04 7,794E-03 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 4,337E-04 7,733E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 4,337E-04 7,674E-03 ! regulation of mRNA processing GO:0050684 18 11 1,000 4,337E-04 7,615E-03 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 4,337E-04 7,557E-03 ! regulation of leukocyte migration GO:0002685 24 11 1,000 4,337E-04 7,501E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 4,337E-04 7,445E-03 GO:0042130|negative regulation of T cell proliferation, ! transition metal ion transport GO:0000041 74 52 2,000 4,408E-04 7,51E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 5,195E-04 8,786E-03 ! cartilage condensation GO:0001502 18 12 1,000 5,195E-04 8,722E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 5,195E-04 8,659E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 5,195E-04 8,596E-03 ! peptidyl-lysine modification GO:0018205 18 12 1,000 5,195E-04 8,535E-03 ! response to gamma radiation GO:0010332 20 12 1,000 5,195E-04 8,474E-03 ! regulation of mRNA stability GO:0043488 27 12 1,000 5,195E-04 8,415E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 5,195E-04 8,356E-03 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 5,485E-04 8,76E-03 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 5,778E-04 9,165E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 6,129E-04 9,655E-03 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 6,129E-04 9,589E-03 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 6,129E-04 9,524E-03 ! regulation of RNA stability GO:0043487 28 13 1,000 6,129E-04 9,46E-03 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 6,393E-04 9,803E-03 ! lung development GO:0030324 94 59 2,000 6,393E-04 9,738E-03 ! regulation of S phase GO:0033261 18 14 1,000 7,137E-04 0,01079928 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 7,137E-04 0,0107287 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 7,137E-04 0,01065903 ! respiratory tube development GO:0030323 99 62 2,000 7,393E-04 0,01097072 ! regulation of transcription factor activity GO:0051090 97 63 2,000 7,747E-04 0,01142246 GO:0090046|regulation of transcription regulator activity, ! respiratory system development GO:0060541 100 64 2,000 8,112E-04 0,01188401 ! lipid phosphorylation GO:0046834 23 15 1,000 8,22E-04 0,01196562 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 8,22E-04 0,01189037 ! centrosome cycle GO:0007098 16 15 1,000 8,22E-04 0,01181605 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 8,22E-04 0,01174266 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 8,22E-04 0,01167017 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 8,22E-04 0,01159858 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of glucose metabolic process GO:0010906 22 16 1,000 9,377E-04 0,01315063 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 9,377E-04 0,01307093 ! protein amino acid acetylation GO:0006473 28 16 1,000 9,377E-04 0,01299219 ! oogenesis GO:0048477 23 16 1,000 9,377E-04 0,01291439 ! activation of protein kinase activity GO:0032147 102 69 2,000 1,01E-03 0,0138266 ! signal complex assembly GO:0007172 29 17 1,000 1,061E-03 0,01443669 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,061E-03 0,01435177 ! neuromuscular junction development GO:0007528 23 17 1,000 1,061E-03 0,01426784 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 1,061E-03 0,01418489 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 1,061E-03 0,0141029 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 1,061E-03 0,01402185 ! response to hypoxia GO:0001666 132 72 2,000 1,143E-03 0,01501858 ! negative regulation of transport GO:0051051 116 73 2,000 1,189E-03 0,01554204 ! positive regulation of DNA replication GO:0045740 29 18 1,000 1,191E-03 0,0154789 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 1,191E-03 0,01539194 ! somitogenesis GO:0001756 24 18 1,000 1,191E-03 0,01530595 ! negative regulation of T cell activation GO:0050868 25 18 1,000 1,191E-03 0,01522092 ! response to oxygen levels GO:0070482 137 74 2,000 1,237E-03 0,0157197 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 1,237E-03 0,01563333 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 1,329E-03 0,0167022 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 1,329E-03 0,01661143 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 1,329E-03 0,01652163 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 1,329E-03 0,01643281 ! sex determination GO:0007530 29 19 1,000 1,329E-03 0,01634493 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 1,329E-03 0,01625799 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,329E-03 0,01617197 ! protein stabilization GO:0050821 26 19 1,000 1,329E-03 0,01608685 ! regulation of protein transport GO:0051223 114 76 2,000 1,336E-03 0,01609041 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 2,000 1,388E-03 0,01662216 ! gland development GO:0048732 148 77 2,000 1,388E-03 0,01653603 ! positive regulation of locomotion GO:0040017 35 20 1,000 1,474E-03 0,01747379 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 31 20 1,000 1,474E-03 0,01738419 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 1,626E-03 0,01908119 ! protein amino acid acylation GO:0043543 37 21 1,000 1,626E-03 0,01898433 ! regulation of chemotaxis GO:0050920 36 21 1,000 1,626E-03 0,01888845 ! cell aging GO:0007569 32 21 1,000 1,626E-03 0,01879354 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 1,626E-03 0,01869957 ! ossification GO:0001503 134 82 2,000 1,663E-03 0,01903106 GO:0060348|bone development, ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 1,785E-03 0,02032872 ! vasculogenesis GO:0001570 33 22 1,000 1,785E-03 0,02022857 ! microtubule organizing center organization GO:0031023 28 22 1,000 1,785E-03 0,02012941 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 1,785E-03 0,02003122 ! regulation of behavior GO:0050795 38 22 1,000 1,785E-03 0,01993398 ! blastocyst development GO:0001824 37 22 1,000 1,785E-03 0,01983768 ! protein tetramerization GO:0051262 39 22 1,000 1,785E-03 0,01974231 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 1,844E-03 0,02029035 ! regulation of protein localization GO:0032880 132 85 2,000 1,844E-03 0,02019373 ! cell cycle arrest GO:0007050 150 86 2,000 1,907E-03 0,02078278 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 1,952E-03 0,02117587 ! myelination GO:0042552 35 23 1,000 1,952E-03 0,02107645 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,952E-03 0,02097796 ! negative regulation of DNA replication GO:0008156 35 23 1,000 1,952E-03 0,02088039 ! interaction with host GO:0051701 37 23 1,000 1,952E-03 0,02078372 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 1,952E-03 0,02068794 ! negative regulation of catabolic process GO:0009895 34 23 1,000 1,952E-03 0,02059305 ! skeletal muscle tissue development GO:0007519 123 87 2,000 1,971E-03 0,02069722 GO:0060538|skeletal muscle organ development, ! reproductive developmental process GO:0003006 127 89 2,000 2,103E-03 0,02198614 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 2,125E-03 0,02211978 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 2,125E-03 0,02202014 ! receptor metabolic process GO:0043112 37 24 1,000 2,125E-03 0,02192139 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 2,125E-03 0,02182353 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 2,306E-03 0,02357275 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 2,306E-03 0,02346844 ! response to oxidative stress GO:0006979 141 94 2,000 2,458E-03 0,02490031 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 2,494E-03 0,02515519 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 2,494E-03 0,02504534 ! regulation of binding GO:0051098 151 95 2,000 2,533E-03 0,02532615 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 2,609E-03 0,0259779 ! response to ionizing radiation GO:0010212 47 27 1,000 2,688E-03 0,02665054 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 2,688E-03 0,02653616 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 2,688E-03 0,02642276 GO:0043433|negative regulation of transcription factor activity, ! response to organic cyclic substance GO:0014070 47 28 1,000 2,89E-03 0,02828257 ! ensheathment of neurons GO:0007272 43 28 1,000 2,89E-03 0,02816272 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 1,000 2,89E-03 0,02804389 ! mismatch repair GO:0006298 34 29 1,000 3,098E-03 0,02994002 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 3,098E-03 0,02981475 ! tissue homeostasis GO:0001894 42 29 1,000 3,098E-03 0,02969052 GO:0048871|multicellular organismal homeostasis, ! negative regulation of cell activation GO:0050866 44 30 1,000 3,313E-03 0,03162157 ! maintenance of protein location in cell GO:0032507 60 31 1,000 3,535E-03 0,03360139 ! segmentation GO:0035282 41 31 1,000 3,535E-03 0,03346311 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 3,764E-03 0,03548298 ! peripheral nervous system development GO:0007422 53 32 1,000 3,764E-03 0,03533815 ! calcium-mediated signaling GO:0019722 50 32 1,000 3,764E-03 0,0351945 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 3,764E-03 0,03505201 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 4E-03 0,03709533 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 4E-03 0,03694635 ! carbohydrate homeostasis GO:0033500 39 33 1,000 4E-03 0,03679857 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 4E-03 0,03665196 ! negative regulation of DNA binding GO:0043392 54 33 1,000 4E-03 0,03650651 ! cytokinesis GO:0000910 52 33 1,000 4E-03 0,03636222 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 4,242E-03 0,03841271 ! female gamete generation GO:0007292 43 34 1,000 4,242E-03 0,03826208 ! regulation of action potential in neuron GO:0019228 54 35 1,000 4,491E-03 0,04034892 ! maintenance of protein location GO:0045185 65 35 1,000 4,491E-03 0,04019192 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 4,491E-03 0,04003613 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 4,747E-03 0,0421507 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 1,000 4,747E-03 0,04198859 ! tissue remodeling GO:0048771 62 36 1,000 4,747E-03 0,04182771 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 4,747E-03 0,04166806 GO:0046660|female sex differentiation, ! regulation of T cell proliferation GO:0042129 58 38 1,000 5,277E-03 0,04615114 ! maintenance of location in cell GO:0051651 69 38 1,000 5,277E-03 0,04597632 ! chromatin remodeling GO:0006338 68 39 1,000 5,552E-03 0,04819088 ! developmental growth GO:0048589 62 39 1,000 5,552E-03 0,04800971 ! synapse organization GO:0050808 55 39 1,000 5,552E-03 0,0478299 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 5,834E-03 0,05006821 ! double-strand break repair GO:0006302 67 40 1,000 5,834E-03 0,04988208 ! positive regulation of protein transport GO:0051222 55 40 1,000 5,834E-03 0,04969734 ! endosome transport GO:0016197 71 41 1,000 6,122E-03 0,05195852 ! positive regulation of DNA binding GO:0043388 57 41 1,000 6,122E-03 0,0517675 ! regulation of T cell differentiation GO:0045580 59 41 1,000 6,122E-03 0,05157787 ! regulation of cell shape GO:0008360 78 42 1,000 6,416E-03 0,05386106 ! positive regulation of binding GO:0051099 59 43 1,000 6,717E-03 0,05618076 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 6,717E-03 0,0559772 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 6,717E-03 0,05577512 ! regulation of action potential GO:0001508 71 44 1,000 7,024E-03 0,05811514 ! vascular process in circulatory system GO:0003018 69 45 1,000 7,338E-03 0,06049012 ! cell maturation GO:0048469 60 45 1,000 7,338E-03 0,06027409 ! histone modification GO:0016570 68 46 1,000 7,657E-03 0,06267556 ! response to estrogen stimulus GO:0043627 74 47 1,000 7,983E-03 0,06511059 ! covalent chromatin modification GO:0016569 75 47 1,000 7,983E-03 0,06488051 ! negative regulation of immune system process GO:0002683 73 47 1,000 7,983E-03 0,06465206 ! heart morphogenesis GO:0003007 65 48 1,000 8,315E-03 0,06710429 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 8,315E-03 0,06686966 ! regulation of angiogenesis GO:0045765 94 49 1,000 8,653E-03 0,06934619 ! germ cell development GO:0007281 68 49 1,000 8,653E-03 0,06910541 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 8,653E-03 0,06886629 ! cartilage development GO:0051216 70 49 1,000 8,653E-03 0,06862882 ! maintenance of location GO:0051235 84 49 1,000 8,653E-03 0,06839298 ! skeletal muscle fiber development GO:0048741 73 50 1,000 8,997E-03 0,07086989 ! positive regulation of growth GO:0045927 67 50 1,000 8,997E-03 0,07062801 ! activation of phospholipase C activity GO:0007202 87 51 1,000 9,348E-03 0,07312785 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 9,348E-03 0,07287996 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 9,704E-03 0,07540209 ! nucleotide-excision repair GO:0006289 64 52 1,000 9,704E-03 0,07514821 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,01006618 0,077692 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,01006618 0,07743216 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01043439 0,07999699 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,01043439 0,07973122 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01043439 0,07946721 ! developmental maturation GO:0021700 75 57 1,000 0,01157436 0,08785819 ! gonad development GO:0008406 79 57 1,000 0,01157436 0,08756918 ! viral reproductive process GO:0022415 87 58 1,000 0,01196601 0,09023552 ! activation of MAPK activity GO:0000187 84 59 1,000 0,01236344 0,09292783 ! actin filament organization GO:0007015 95 59 1,000 0,01236344 0,09262513 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,01276661 0,09533505 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,01276661 0,09502652 ! meiosis GO:0007126 96 61 1,000 0,01317548 0,09775353 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,01317548 0,09743921 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,01359001 0,10018279 ! meiotic cell cycle GO:0051321 97 62 1,000 0,01359001 0,09986272 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,01401019 0,10262239 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,01401019 0,1022966 ! viral reproduction GO:0016032 92 63 1,000 0,01401019 0,10197288 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01401019 0,1016512 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01422047 0,10285248 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01422047 0,10253006 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01422047 0,10220965 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01422047 0,10189124 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01422047 0,10157481 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01422047 0,10126034 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01422047 0,10094781 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01422047 0,1006372 ! sleep GO:0030431 11 5 0,000 0,01422047 0,1003285 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01422047 0,10002168 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01422047 0,09971674 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01422047 0,09941365 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01422047 0,09911239 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01422047 0,09881296 ! tongue development GO:0043586 6 5 0,000 0,01422047 0,09851533 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01422047 0,09821949 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01422047 0,09792542 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01422047 0,0976331 ! cobalt ion transport GO:0006824 9 5 0,000 0,01422047 0,09734253 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01422047 0,09705368 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01422047 0,09676654 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01422047 0,09648109 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01422047 0,09619732 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01422047 0,09591522 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01422047 0,09563476 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01422047 0,09535595 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01422047 0,09507875 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01422047 0,09480316 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01422047 0,09452916 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01422047 0,09425674 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01422047 0,09398589 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01422047 0,09371659 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01422047 0,09344883 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01422047 0,09318259 ! malate metabolic process GO:0006108 7 5 0,000 0,01422047 0,09291787 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01422047 0,09265464 ! behavioral response to pain GO:0048266 7 5 0,000 0,01422047 0,09239291 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01422047 0,09213265 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01422047 0,09187385 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01422047 0,0916165 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01422047 0,09136059 ! mating behavior GO:0007617 6 5 0,000 0,01422047 0,0911061 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01422047 0,09085303 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01422047 0,09060136 ! rhythmic behavior GO:0007622 12 5 0,000 0,01422047 0,09035108 ! copulation GO:0007620 7 5 0,000 0,01422047 0,09010218 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01422047 0,08985464 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01422047 0,08960846 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01422047 0,08936363 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01422047 0,08912014 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01422047 0,08887796 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01422047 0,0886371 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01422047 0,08839754 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01422047 0,08815927 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01422047 0,08792228 ! response to protozoan GO:0001562 9 5 0,000 0,01422047 0,08768657 ! lymph vessel development GO:0001945 7 5 0,000 0,01422047 0,08745211 ! endochondral ossification GO:0001958 12 5 0,000 0,01422047 0,08721891 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01422047 0,08698694 ! parathyroid gland development GO:0060017 8 5 0,000 0,01422047 0,08675621 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01422047 0,08652669 ! anagen GO:0042640 6 5 0,000 0,01422047 0,08629839 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01422047 0,08607129 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01422047 0,08584538 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01422047 0,08562065 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01422047 0,0853971 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01422047 0,08517471 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01422047 0,08495348 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01422047 0,08473339 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01422047 0,08451444 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01422047 0,08429662 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01422047 0,08407992 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01422047 0,08386433 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01422047 0,08364985 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01422047 0,08343645 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01422047 0,08322415 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01422047 0,08301292 ! ovulation GO:0030728 6 5 0,000 0,01422047 0,08280276 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01422047 0,08259366 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01422047 0,08238562 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01422047 0,08217862 ! response to pH GO:0009268 9 5 0,000 0,01422047 0,08197266 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01422047 0,08176772 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01422047 0,08156381 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01422047 0,08136092 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01422047 0,08115903 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01422047 0,08095814 ! polyol catabolic process GO:0046174 7 5 0,000 0,01422047 0,08075825 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01422047 0,08055933 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01422047 0,0803614 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01422047 0,08016444 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01422047 0,07996843 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01422047 0,07977339 ! urea metabolic process GO:0019627 6 5 0,000 0,01422047 0,07957929 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01422047 0,07938614 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01422047 0,07919392 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01422047 0,07900263 ! neutrophil activation GO:0042119 5 5 0,000 0,01422047 0,07881226 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01422047 0,07862281 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01422047 0,07843427 ! response to food GO:0032094 5 5 0,000 0,01422047 0,07824663 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01422047 0,07805988 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01422047 0,07787402 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01422047 0,07768905 ! forebrain neuron development GO:0021884 7 5 0,000 0,01422047 0,07750495 ! melanosome organization GO:0032438 7 5 0,000 0,01422047 0,07732172 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01422047 0,07713936 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01422047 0,07695786 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01422047 0,07677721 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01422047 0,0765974 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01422047 0,07641843 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01422047 0,0762403 ! nucleoside transport GO:0015858 6 5 0,000 0,01422047 0,076063 ! nucleoside salvage GO:0043174 7 5 0,000 0,01422047 0,07588652 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01422047 0,07571086 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01422047 0,075536 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01422047 0,07536196 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01422047 0,07518871 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01422047 0,07501626 ! depyrimidination GO:0045008 8 5 0,000 0,01422047 0,0748446 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01422047 0,07467372 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01422047 0,07450362 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01422047 0,07433429 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01422047 0,07416574 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01422047 0,07399794 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01422047 0,0738309 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01422047 0,07366462 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01422047 0,07349908 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01422047 0,07333428 ! monocyte differentiation GO:0030224 8 5 0,000 0,01422047 0,07317022 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01422047 0,0730069 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01422047 0,0728443 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01422047 0,07268242 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01422047 0,07252126 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01422047 0,07236082 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01422047 0,07220108 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01422047 0,07204205 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01422047 0,07188371 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01422047 0,07172607 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01422047 0,07156912 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01422047 0,07141286 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01422047 0,07125728 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01422047 0,07110237 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01422047 0,07094813 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01422047 0,07079457 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01422047 0,07064166 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01422047 0,07048942 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01422047 0,07033783 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01422047 0,07018689 ! neural tube patterning GO:0021532 6 5 0,000 0,01422047 0,07003659 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01422047 0,06988694 ! histone demethylation GO:0016577 9 5 0,000 0,01422047 0,06973793 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01422047 0,06958955 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01422047 0,0694418 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01422047 0,06929468 ! enteric nervous system development GO:0048484 8 5 0,000 0,01422047 0,06914818 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01422047 0,0690023 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01422047 0,06885703 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01422047 0,06871237 ! transcription termination GO:0006353 8 5 0,000 0,01422047 0,06856832 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01422047 0,06842487 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01422047 0,06828202 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01422047 0,06813977 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01422047 0,06799811 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01422047 0,06785703 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01422047 0,06771654 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01422047 0,06757663 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01422047 0,0674373 ! apical protein localization GO:0045176 6 5 0,000 0,01422047 0,06729854 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01422047 0,06716035 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01422047 0,06702272 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01422047 0,06688566 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01422047 0,06674916 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01422047 0,06661322 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01422047 0,06647782 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01422047 0,06634298 ! glial cell migration GO:0008347 10 5 0,000 0,01422047 0,06620868 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01422047 0,06607493 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01422047 0,06594171 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01422047 0,06580903 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01422047 0,06567689 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01422047 0,06554527 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01422047 0,06541418 ! neural plate development GO:0001840 6 5 0,000 0,01422047 0,06528361 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01422047 0,06515356 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01422047 0,06502403 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01422047 0,06489502 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01422047 0,06476651 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01422047 0,06463852 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01422047 0,06451102 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01422047 0,06438403 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01422047 0,06425754 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01422047 0,06413155 ! spindle assembly GO:0051225 5 5 0,000 0,01422047 0,06400605 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01422047 0,06388103 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01422047 0,06375651 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01422047 0,06363247 ! organ regeneration GO:0031100 7 5 0,000 0,01422047 0,06350891 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01422047 0,06338583 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01422047 0,06326323 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01422047 0,0631411 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01422047 0,06301944 GO:0055081|anion homeostasis, ! negative regulation of cell size GO:0045792 108 64 1,000 0,01443596 0,06385136 ! adaptive immune response GO:0002250 94 64 1,000 0,01443596 0,06372881 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,0148673 0,06550726 ! protein oligomerization GO:0051259 100 65 1,000 0,0148673 0,06538201 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,01530417 0,0671748 ! axon guidance GO:0007411 99 66 1,000 0,01530417 0,06704685 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,01619438 0,07081192 ! tRNA transcription GO:0009304 11 6 0,000 0,01704069 0,07437115 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01704069 0,07423029 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01704069 0,07408997 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01704069 0,07395018 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01704069 0,07381091 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01704069 0,07367217 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01704069 0,07353395 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01704069 0,07339624 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01704069 0,07325906 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01704069 0,07312238 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01704069 0,07298621 ! prostate gland development GO:0030850 9 6 0,000 0,01704069 0,07285055 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01704069 0,07271539 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01704069 0,07258073 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01704069 0,07244657 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01704069 0,0723129 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01704069 0,07217973 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01704069 0,07204705 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01704069 0,07191485 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01704069 0,07178314 ! neuron adhesion GO:0007158 9 6 0,000 0,01704069 0,07165191 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01704069 0,07152116 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01704069 0,07139088 ! signal peptide processing GO:0006465 8 6 0,000 0,01704069 0,07126108 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01704069 0,07113175 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01704069 0,07100289 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01704069 0,07087449 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01704069 0,07074656 ! opsonization GO:0008228 8 6 0,000 0,01704069 0,07061909 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01704069 0,07049208 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01704069 0,07036552 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01704069 0,07023942 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01704069 0,07011376 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01704069 0,06998856 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01704069 0,0698638 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01704069 0,06973949 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01704069 0,06961562 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01704069 0,06949219 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01704069 0,06936919 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01704069 0,06924663 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01704069 0,06912451 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01704069 0,06900281 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01704069 0,06888154 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01704069 0,06876069 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01704069 0,06864027 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01704069 0,06852027 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01704069 0,06840069 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01704069 0,06828152 ! thymic T cell selection GO:0045061 12 6 0,000 0,01704069 0,06816277 ! protein lipoylation GO:0009249 10 6 0,000 0,01704069 0,06804443 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01704069 0,06792651 ! pigment granule organization GO:0048753 11 6 0,000 0,01704069 0,06780899 ! drug transport GO:0015893 6 6 0,000 0,01704069 0,06769187 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01704069 0,06757516 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01704069 0,06745885 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01704069 0,06734295 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01704069 0,06722743 ! histidine metabolic process GO:0006547 6 6 0,000 0,01704069 0,06711232 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01704069 0,0669976 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01704069 0,06688327 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01704069 0,06676933 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01704069 0,06665577 ! adenohypophysis development GO:0021984 10 6 0,000 0,01704069 0,06654261 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01704069 0,06642982 ! hyperosmotic response GO:0006972 8 6 0,000 0,01704069 0,06631742 ! microtubule nucleation GO:0007020 10 6 0,000 0,01704069 0,0662054 ! ER overload response GO:0006983 7 6 0,000 0,01704069 0,06609375 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01704069 0,06598248 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01704069 0,06587159 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01704069 0,06576106 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01704069 0,06565091 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01704069 0,06554113 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01704069 0,06543171 ! response to dietary excess GO:0002021 7 6 0,000 0,01704069 0,06532266 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01704069 0,06521397 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01704069 0,06510564 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01704069 0,06499767 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01704069 0,06489006 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01704069 0,0647828 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01704069 0,0646759 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01704069 0,06456935 ! neuron apoptosis GO:0051402 8 6 0,000 0,01704069 0,06446315 ! organic alcohol transport GO:0015850 9 6 0,000 0,01704069 0,0643573 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01704069 0,06425179 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01704069 0,06414664 ! carnitine transport GO:0015879 8 6 0,000 0,01704069 0,06404182 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01704069 0,06393735 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01704069 0,06383322 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01704069 0,06372942 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01704069 0,06362597 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01704069 0,06352284 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01704069 0,06342006 ! parturition GO:0007567 12 6 0,000 0,01704069 0,0633176 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01704069 0,06321547 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01704069 0,06311368 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01704069 0,06301221 ! spindle checkpoint GO:0031577 14 6 0,000 0,01704069 0,06291107 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01704069 0,06281025 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01704069 0,06270975 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01704069 0,06260958 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01704069 0,06250972 ! macrophage differentiation GO:0030225 10 6 0,000 0,01704069 0,06241018 ! astrocyte development GO:0014002 14 6 0,000 0,01704069 0,06231096 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01704069 0,06221205 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01704069 0,06211346 ! interaction with symbiont GO:0051702 8 6 0,000 0,01704069 0,06201518 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01704069 0,06191721 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01704069 0,06181955 ! eating behavior GO:0042755 6 6 0,000 0,01704069 0,0617222 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01704069 0,06162515 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01704069 0,06152841 ! response to copper ion GO:0046688 9 6 0,000 0,01704069 0,06143197 ! DNA topological change GO:0006265 8 6 0,000 0,01704069 0,06133583 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01704069 0,06123999 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01704069 0,06114445 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01704069 0,06104921 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01704069 0,06095427 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01704069 0,06085962 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01704069 0,06076526 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01704069 0,0606712 ! gas homeostasis GO:0033483 11 6 0,000 0,01704069 0,06057743 ! hair follicle maturation GO:0048820 7 6 0,000 0,01704069 0,06048394 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01704069 0,06039075 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01704069 0,06029784 ! Schwann cell development GO:0014044 14 6 0,000 0,01704069 0,06020521 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01704069 0,06011287 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01704069 0,06002082 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01704069 0,05992904 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01704069 0,05983755 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01704069 0,05974633 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01704069 0,05965539 ! histone ubiquitination GO:0016574 7 6 0,000 0,01704069 0,05956473 ! regulation of meiosis GO:0040020 10 6 0,000 0,01704069 0,05947435 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01704069 0,05938423 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01704069 0,05929439 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01704069 0,05920483 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01704069 0,05911553 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01704069 0,0590265 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01704069 0,05893774 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01704069 0,05884924 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01704069 0,05876101 ! receptor internalization GO:0031623 9 6 0,000 0,01704069 0,05867305 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01704069 0,05858534 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01704069 0,0584979 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01704069 0,05841072 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01704069 0,0583238 ! protein deubiquitination GO:0016579 8 6 0,000 0,01704069 0,05823714 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01704069 0,05815073 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01704069 0,05806458 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01704069 0,05797869 ! axonal fasciculation GO:0007413 9 6 0,000 0,01704069 0,05789305 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01704069 0,05780766 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01704069 0,05772252 ! midbrain development GO:0030901 6 6 0,000 0,01704069 0,05763764 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01704069 0,057553 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01704069 0,05746861 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01704069 0,05738447 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01704069 0,05730058 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01704069 0,05721693 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01704069 0,05713352 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01704069 0,05705036 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01704069 0,05696743 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01704069 0,05688475 ! adult feeding behavior GO:0008343 6 6 0,000 0,01704069 0,05680231 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01704069 0,05672011 ! pigment granule transport GO:0051904 12 6 0,000 0,01704069 0,05663814 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01704069 0,05655641 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01704069 0,05647492 ! catecholamine transport GO:0051937 7 6 0,000 0,01704069 0,05639366 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01704069 0,05631264 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01704069 0,05623184 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01704069 0,05615128 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01704069 0,05607095 ! protein prenylation GO:0018342 10 6 0,000 0,01704069 0,05599085 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01704069 0,05591098 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01704069 0,05583133 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01704069 0,05575191 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01704069 0,05567272 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,01710631 0,05580782 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,01757034 0,05724048 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,0180397 0,05868643 GO:0045937|positive regulation of phosphate metabolic process, ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,01851436 0,06014551 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,01899428 0,06161756 ! negative regulation of growth GO:0045926 123 75 1,000 0,01947944 0,06310241 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01985301 0,0642221 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01985301 0,0641319 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01985301 0,06404195 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01985301 0,06395226 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01985301 0,06386281 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01985301 0,06377362 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01985301 0,06368468 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01985301 0,06359598 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01985301 0,06350753 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01985301 0,06341932 ! reproductive behavior GO:0019098 12 7 0,000 0,01985301 0,06333136 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01985301 0,06324365 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01985301 0,06315617 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01985301 0,06306894 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01985301 0,06298195 ! oligopeptide transport GO:0006857 11 7 0,000 0,01985301 0,0628952 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01985301 0,06280868 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01985301 0,06272241 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,01985301 0,06263637 ! RNA methylation GO:0001510 11 7 0,000 0,01985301 0,06255056 ! pericardium development GO:0060039 8 7 0,000 0,01985301 0,062465 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01985301 0,06237966 ! fibril organization GO:0043206 13 7 0,000 0,01985301 0,06229456 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01985301 0,06220969 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01985301 0,06212505 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01985301 0,06204064 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01985301 0,06195646 ! lipoprotein transport GO:0042953 9 7 0,000 0,01985301 0,06187251 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01985301 0,06178879 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01985301 0,06170529 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01985301 0,06162201 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01985301 0,06153897 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01985301 0,06145614 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01985301 0,06137354 ! chemosensory behavior GO:0007635 9 7 0,000 0,01985301 0,06129116 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01985301 0,061209 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01985301 0,06112706 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01985301 0,06104534 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01985301 0,06096383 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01985301 0,06088255 ! reflex GO:0060004 12 7 0,000 0,01985301 0,06080148 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01985301 0,06072063 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01985301 0,06063999 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01985301 0,06055957 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01985301 0,06047935 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01985301 0,06039935 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01985301 0,06031957 ! spinal cord patterning GO:0021511 7 7 0,000 0,01985301 0,06023999 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01985301 0,06016062 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01985301 0,06008146 ! adrenal gland development GO:0030325 17 7 0,000 0,01985301 0,06000251 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01985301 0,05992377 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01985301 0,05984523 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01985301 0,0597669 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01985301 0,05968877 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01985301 0,05961085 ! endosome organization GO:0007032 10 7 0,000 0,01985301 0,05953313 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01985301 0,05945561 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01985301 0,0593783 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01985301 0,05930118 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01985301 0,05922427 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01985301 0,05914755 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01985301 0,05907104 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01985301 0,05899472 ! galactose metabolic process GO:0006012 10 7 0,000 0,01985301 0,0589186 ! vesicle fusion GO:0006906 15 7 0,000 0,01985301 0,05884267 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01985301 0,05876694 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01985301 0,0586914 ! organ growth GO:0035265 11 7 0,000 0,01985301 0,05861606 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01985301 0,05854091 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01985301 0,05846596 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01985301 0,05839119 ! retinol metabolic process GO:0042572 9 7 0,000 0,01985301 0,05831662 ! behavioral fear response GO:0001662 13 7 0,000 0,01985301 0,05824223 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01985301 0,05816804 ! rRNA modification GO:0000154 12 7 0,000 0,01985301 0,05809404 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01985301 0,05802022 ! response to UV-B GO:0010224 11 7 0,000 0,01985301 0,05794659 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01985301 0,05787315 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01985301 0,05779989 ! intermediate filament organization GO:0045109 11 7 0,000 0,01985301 0,05772682 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01985301 0,05765393 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01985301 0,05758123 ! fibrinolysis GO:0042730 9 7 0,000 0,01985301 0,05750871 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01985301 0,05743637 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01985301 0,05736421 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01985301 0,05729224 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01985301 0,05722044 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01985301 0,05714883 ! response to tropane GO:0014073 13 7 0,000 0,01985301 0,05707739 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01985301 0,05700613 ! melanosome localization GO:0032400 10 7 0,000 0,01985301 0,05693505 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01985301 0,05686415 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01985301 0,05679342 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01985301 0,05672287 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01985301 0,0566525 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01985301 0,0565823 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01985301 0,05651227 ! mast cell activation GO:0045576 9 7 0,000 0,01985301 0,05644241 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01985301 0,05637273 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01985301 0,05630322 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01985301 0,05623388 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01985301 0,05616471 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01985301 0,05609572 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01985301 0,05602689 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01985301 0,05595823 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01985301 0,05588973 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01985301 0,05582141 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01985301 0,05575325 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01985301 0,05568526 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01985301 0,05561743 ! response to tumor cell GO:0002347 12 7 0,000 0,01985301 0,05554977 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01985301 0,05548227 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01985301 0,05541494 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01985301 0,05534777 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01985301 0,05528077 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01985301 0,05521392 ! diuresis GO:0030146 12 7 0,000 0,01985301 0,05514724 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01985301 0,05508071 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01985301 0,05501435 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01985301 0,05494815 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01985301 0,05488211 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01985301 0,05481622 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01985301 0,05475049 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01985301 0,05468492 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01985301 0,05461951 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01985301 0,05455426 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01985301 0,05448916 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01985301 0,05442421 ! lymph node development GO:0048535 9 7 0,000 0,01985301 0,05435942 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01985301 0,05429478 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01985301 0,0542303 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01985301 0,05416597 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,01985301 0,05410179 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01985301 0,05403777 ! ATP catabolic process GO:0006200 10 7 0,000 0,01985301 0,05397389 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01985301 0,05391017 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01985301 0,05384659 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01985301 0,05378317 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01985301 0,0537199 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01985301 0,05365677 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01985301 0,05359379 ! muscle adaptation GO:0043500 12 7 0,000 0,01985301 0,05353096 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01985301 0,05346828 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01985301 0,05340575 ! retina homeostasis GO:0001895 9 7 0,000 0,01985301 0,05334336 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01985301 0,05328111 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01985301 0,05321901 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01985301 0,05315706 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01985301 0,05309525 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01985301 0,05303358 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01985301 0,05297206 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01985301 0,05291067 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,0199698 0,05316034 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,02046532 0,05441647 ! sex differentiation GO:0007548 105 77 1,000 0,02046532 0,05435363 ! protein ubiquitination GO:0016567 125 77 1,000 0,02046532 0,05429094 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,02096598 0,05555503 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,02147175 0,05682972 ! regulation of lyase activity GO:0051339 133 79 1,000 0,02147175 0,05676439 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,02249846 0,0594104 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,02249846 0,05934227 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,02249846 0,05927429 GO:0002696|positive regulation of leukocyte activation, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02265743 0,05962482 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02265743 0,05955668 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,02265743 0,05948869 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02265743 0,05942086 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02265743 0,05935318 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02265743 0,05928566 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02265743 0,05921829 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02265743 0,05915107 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02265743 0,05908401 ! phosphate transport GO:0006817 10 8 0,000 0,02265743 0,05901709 ! N-glycan processing GO:0006491 12 8 0,000 0,02265743 0,05895033 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02265743 0,05888372 ! UTP metabolic process GO:0046051 8 8 0,000 0,02265743 0,05881726 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02265743 0,05875095 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02265743 0,05868479 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02265743 0,05861878 ! succinate metabolic process GO:0006105 14 8 0,000 0,02265743 0,05855291 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,02265743 0,0584872 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02265743 0,05842163 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02265743 0,05835621 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02265743 0,05829093 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02265743 0,0582258 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02265743 0,05816082 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02265743 0,05809598 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02265743 0,05803128 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02265743 0,05796673 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02265743 0,05790233 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02265743 0,05783806 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02265743 0,05777394 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02265743 0,05770996 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02265743 0,05764612 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02265743 0,05758242 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02265743 0,05751887 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02265743 0,05745545 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02265743 0,05739217 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02265743 0,05732903 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02265743 0,05726604 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02265743 0,05720318 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02265743 0,05714045 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02265743 0,05707787 ! melanin metabolic process GO:0006582 12 8 0,000 0,02265743 0,05701542 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02265743 0,05695311 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02265743 0,05689093 ! macrophage activation GO:0042116 12 8 0,000 0,02265743 0,05682889 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02265743 0,05676699 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02265743 0,05670522 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02265743 0,05664358 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02265743 0,05658208 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02265743 0,05652071 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02265743 0,05645947 ! ruffle organization GO:0031529 11 8 0,000 0,02265743 0,05639837 ! osteoblast development GO:0002076 13 8 0,000 0,02265743 0,0563374 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02265743 0,05627656 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02265743 0,05621585 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02265743 0,05615527 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02265743 0,05609483 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02265743 0,05603451 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02265743 0,05597432 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02265743 0,05591426 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02265743 0,05585433 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02265743 0,05579453 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02265743 0,05573486 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02265743 0,05567531 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02265743 0,05561589 ! segment specification GO:0007379 10 8 0,000 0,02265743 0,0555566 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02265743 0,05549744 ! cellular extravasation GO:0045123 11 8 0,000 0,02265743 0,0554384 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02265743 0,05537948 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02265743 0,05532069 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02265743 0,05526203 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02265743 0,05520349 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02265743 0,05514507 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02265743 0,05508678 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02265743 0,05502861 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02265743 0,05497056 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02265743 0,05491264 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02265743 0,05485483 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02265743 0,05479715 ! icosanoid secretion GO:0032309 12 8 0,000 0,02265743 0,05473959 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02265743 0,05468215 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02265743 0,05462484 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02265743 0,05456764 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02265743 0,05451056 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02265743 0,0544536 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02265743 0,05439676 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02265743 0,05434003 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02265743 0,05428343 ! sterol catabolic process GO:0016127 9 8 0,000 0,02265743 0,05422694 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02265743 0,05417057 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02265743 0,05411432 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02265743 0,05405819 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02265743 0,05400217 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02265743 0,05394627 ! prophase GO:0051324 11 8 0,000 0,02265743 0,05389048 ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02265743 0,05383481 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02265743 0,05377925 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02265743 0,05372381 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02265743 0,05366848 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02265743 0,05361326 ! hormone catabolic process GO:0042447 13 8 0,000 0,02265743 0,05355816 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02265743 0,05350318 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02265743 0,0534483 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02265743 0,05339354 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02265743 0,05333889 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02265743 0,05328435 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02265743 0,05322992 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02265743 0,0531756 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02265743 0,0531214 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02265743 0,0530673 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02265743 0,05301332 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02265743 0,05295944 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02265743 0,05290568 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02265743 0,05285202 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02265743 0,05279847 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,0235452 0,0548117 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,024076 0,05599071 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,02461172 0,05717875 ! regulation of membrane potential GO:0042391 128 85 1,000 0,02461172 0,05712105 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,02461172 0,05706347 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,02515232 0,05825814 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02545399 0,05889757 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02545399 0,05883838 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02545399 0,0587793 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02545399 0,05872035 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02545399 0,05866151 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02545399 0,05860279 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02545399 0,05854419 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02545399 0,0584857 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02545399 0,05842733 ! GTP metabolic process GO:0046039 9 9 0,000 0,02545399 0,05836908 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02545399 0,05831094 ! social behavior GO:0035176 14 9 0,000 0,02545399 0,05825292 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02545399 0,05819502 ! artery development GO:0060840 19 9 0,000 0,02545399 0,05813723 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02545399 0,05807955 ! response to pain GO:0048265 16 9 0,000 0,02545399 0,05802199 ! protein complex disassembly GO:0043241 17 9 0,000 0,02545399 0,05796454 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02545399 0,05790721 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02545399 0,05784999 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02545399 0,05779288 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02545399 0,05773588 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02545399 0,057679 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02545399 0,05762223 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02545399 0,05756557 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02545399 0,05750902 ! protein targeting to ER GO:0045047 19 9 0,000 0,02545399 0,05745259 ! T cell selection GO:0045058 18 9 0,000 0,02545399 0,05739626 ! endoderm development GO:0007492 12 9 0,000 0,02545399 0,05734004 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02545399 0,05728394 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02545399 0,05722794 ! arginine catabolic process GO:0006527 10 9 0,000 0,02545399 0,05717206 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02545399 0,05711628 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02545399 0,05706061 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02545399 0,05700505 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02545399 0,0569496 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02545399 0,05689425 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02545399 0,05683902 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02545399 0,05678389 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02545399 0,05672886 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02545399 0,05667395 ! mannose metabolic process GO:0006013 9 9 0,000 0,02545399 0,05661914 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02545399 0,05656443 ! epithelial cell development GO:0002064 10 9 0,000 0,02545399 0,05650983 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02545399 0,05645534 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02545399 0,05640095 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02545399 0,05634667 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02545399 0,05629249 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02545399 0,05623841 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02545399 0,05618444 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02545399 0,05613057 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02545399 0,05607681 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02545399 0,05602314 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02545399 0,05596958 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02545399 0,05591613 ! DNA ligation GO:0006266 14 9 0,000 0,02545399 0,05586277 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02545399 0,05580952 ! response to amine stimulus GO:0014075 13 9 0,000 0,02545399 0,05575637 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02545399 0,05570332 ! erythrocyte development GO:0048821 11 9 0,000 0,02545399 0,05565037 ! renal water homeostasis GO:0003091 14 9 0,000 0,02545399 0,05559752 ! postreplication repair GO:0006301 11 9 0,000 0,02545399 0,05554477 ! mRNA cleavage GO:0006379 13 9 0,000 0,02545399 0,05549212 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02545399 0,05543957 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02545399 0,05538712 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02545399 0,05533477 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02545399 0,05528252 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02545399 0,05523036 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02545399 0,05517831 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02545399 0,05512635 ! acid secretion GO:0046717 14 9 0,000 0,02545399 0,05507449 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02545399 0,05502273 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02545399 0,05497107 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02545399 0,0549195 ! purine base metabolic process GO:0006144 18 9 0,000 0,02545399 0,05486803 ! thymus development GO:0048538 15 9 0,000 0,02545399 0,05481665 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02545399 0,05476537 ! spleen development GO:0048536 15 9 0,000 0,02545399 0,05471419 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02545399 0,05466311 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02545399 0,05461211 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02545399 0,05456122 ! detection of calcium ion GO:0005513 13 9 0,000 0,02545399 0,05451042 ! blastocyst formation GO:0001825 12 9 0,000 0,02545399 0,05445971 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02545399 0,05440909 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02545399 0,05435858 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02545399 0,05430815 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02545399 0,05425782 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02545399 0,05420758 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02545399 0,05415743 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02545399 0,05410738 ! prepulse inhibition GO:0060134 14 9 0,000 0,02545399 0,05405742 ! embryonic placenta development GO:0001892 12 9 0,000 0,02545399 0,05400755 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02545399 0,05395777 ! insulin secretion GO:0030073 17 9 0,000 0,02545399 0,05390809 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02545399 0,0538585 ! response to nicotine GO:0035094 16 9 0,000 0,02545399 0,05380899 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02545399 0,05375958 ! nucleus localization GO:0051647 15 9 0,000 0,02545399 0,05371026 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02545399 0,05366103 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,02569777 0,05412534 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,02624804 0,05523375 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,02680309 0,0563502 ! regulation of T cell activation GO:0050863 128 89 1,000 0,02680309 0,05629874 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,02736291 0,05742217 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02824271 0,05921444 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02824271 0,05916051 ! neuron fate specification GO:0048665 11 10 0,000 0,02824271 0,05910668 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02824271 0,05905295 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02824271 0,05899931 ! thyroid gland development GO:0030878 19 10 0,000 0,02824271 0,05894577 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02824271 0,05889233 ! synapsis GO:0007129 13 10 0,000 0,02824271 0,05883899 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02824271 0,05878574 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02824271 0,05873259 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02824271 0,05867953 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02824271 0,05862657 ! sulfate transport GO:0008272 12 10 0,000 0,02824271 0,05857371 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02824271 0,05852094 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02824271 0,05846826 ! androgen metabolic process GO:0008209 13 10 0,000 0,02824271 0,05841568 ! phospholipid efflux GO:0033700 16 10 0,000 0,02824271 0,0583632 ! hippocampus development GO:0021766 19 10 0,000 0,02824271 0,05831081 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02824271 0,05825851 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02824271 0,05820631 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02824271 0,0581542 ! pathogenesis GO:0009405 13 10 0,000 0,02824271 0,05810218 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02824271 0,05805026 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02824271 0,05799843 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02824271 0,05794669 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02824271 0,05789505 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02824271 0,05784349 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02824271 0,05779203 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02824271 0,05774066 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02824271 0,05768938 ! B cell proliferation GO:0042100 14 10 0,000 0,02824271 0,05763819 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02824271 0,05758709 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02824271 0,05753609 ! forebrain cell migration GO:0021885 17 10 0,000 0,02824271 0,05748517 ! lipid digestion GO:0044241 15 10 0,000 0,02824271 0,05743434 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02824271 0,05738361 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02824271 0,05733296 ! UV protection GO:0009650 14 10 0,000 0,02824271 0,0572824 ! entry into host cell GO:0030260 20 10 0,000 0,02824271 0,05723193 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02824271 0,05718155 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02824271 0,05713126 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02824271 0,05708106 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02824271 0,05703094 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02824271 0,05698091 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02824271 0,05693097 ! regulation of organ growth GO:0046620 11 10 0,000 0,02824271 0,05688112 ! response to dsRNA GO:0043331 18 10 0,000 0,02824271 0,05683136 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02824271 0,05678168 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02824271 0,05673209 ! embryonic axis specification GO:0000578 12 10 0,000 0,02824271 0,05668258 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02824271 0,05663317 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02824271 0,05658383 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02824271 0,05653459 ! cranial nerve development GO:0021545 12 10 0,000 0,02824271 0,05648543 ! fucose catabolic process GO:0019317 16 10 0,000 0,02824271 0,05643635 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02824271 0,05638736 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02824271 0,05633846 ! protein sumoylation GO:0016925 12 10 0,000 0,02824271 0,05628964 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02824271 0,0562409 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02824271 0,05619225 ! zymogen activation GO:0031638 14 10 0,000 0,02824271 0,05614368 ! salivary gland development GO:0007431 22 10 0,000 0,02824271 0,0560952 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02824271 0,0560468 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02824271 0,05599848 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02824271 0,05595025 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02824271 0,0559021 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02824271 0,05585403 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02824271 0,05580605 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02824271 0,05575815 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02824271 0,05571033 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02824271 0,05566259 ! detection of bacterium GO:0016045 10 10 0,000 0,02824271 0,05561493 ! embryonic gut development GO:0048566 11 10 0,000 0,02824271 0,05556736 ! activation of innate immune response GO:0002218 10 10 0,000 0,02824271 0,05551986 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02824271 0,05547245 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02824271 0,05542512 ! developmental induction GO:0031128 13 10 0,000 0,02824271 0,05537787 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02824271 0,0553307 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02824271 0,05528361 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02824271 0,0552366 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,0284967 0,05568598 ! DNA recombination GO:0006310 146 92 1,000 0,0284967 0,05563871 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,03082003 0,06012389 ! in utero embryonic development GO:0001701 147 96 1,000 0,03082003 0,06007293 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,03082003 0,06002207 ! rRNA transcription GO:0009303 17 11 0,000 0,03102361 0,06036744 ! respiratory burst GO:0045730 14 11 0,000 0,03102361 0,06031641 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03102361 0,06026546 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03102361 0,06021461 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03102361 0,06016384 ! filopodium assembly GO:0046847 19 11 0,000 0,03102361 0,06011315 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03102361 0,06006255 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03102361 0,06001203 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03102361 0,0599616 ! mating GO:0007618 14 11 0,000 0,03102361 0,05991126 ! T cell proliferation GO:0042098 20 11 0,000 0,03102361 0,059861 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03102361 0,05981082 ! bone resorption GO:0045453 16 11 0,000 0,03102361 0,05976073 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03102361 0,05971072 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,03102361 0,05966079 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03102361 0,05961095 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03102361 0,05956119 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03102361 0,05951152 ! syncytium formation GO:0006949 15 11 0,000 0,03102361 0,05946192 ! plasma membrane organization GO:0007009 18 11 0,000 0,03102361 0,05941241 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03102361 0,05936299 ! focal adhesion formation GO:0048041 24 11 0,000 0,03102361 0,05931364 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03102361 0,05926438 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03102361 0,05921519 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,03102361 0,05916609 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03102361 0,05911707 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03102361 0,05906814 ! adult heart development GO:0007512 11 11 0,000 0,03102361 0,05901928 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,03102361 0,0589705 ! temperature homeostasis GO:0001659 16 11 0,000 0,03102361 0,05892181 ! L-glutamate transport GO:0015813 16 11 0,000 0,03102361 0,05887319 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03102361 0,05882466 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03102361 0,0587762 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03102361 0,05872783 ! stem cell development GO:0048864 29 11 0,000 0,03102361 0,05867953 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,03102361 0,05863131 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03102361 0,05858318 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03102361 0,05853512 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03102361 0,05848714 ! vasoconstriction GO:0042310 15 11 0,000 0,03102361 0,05843924 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03102361 0,05839141 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03102361 0,05834367 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03102361 0,058296 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03102361 0,05824842 ! ribosome assembly GO:0042255 13 11 0,000 0,03102361 0,0582009 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,03102361 0,05815347 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,03102361 0,05810611 ! chromatin silencing GO:0006342 19 11 0,000 0,03102361 0,05805884 ! nucleosome positioning GO:0016584 13 11 0,000 0,03102361 0,05801163 ! T cell homeostasis GO:0043029 20 11 0,000 0,03102361 0,05796451 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03102361 0,05791746 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03102361 0,05787049 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03102361 0,05782359 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03102361 0,05777677 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03102361 0,05773002 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03102361 0,05768335 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03102361 0,05763676 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03102361 0,05759024 ! male genitalia development GO:0030539 13 11 0,000 0,03102361 0,0575438 ! cholesterol efflux GO:0033344 19 11 0,000 0,03102361 0,05749743 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03102361 0,05745113 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03102361 0,05740491 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03102361 0,05735877 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,03102361 0,0573127 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,03102361 0,0572667 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03102361 0,05722078 ! defense response to fungus GO:0050832 12 11 0,000 0,03102361 0,05717493 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03102361 0,05712915 ! lysogeny GO:0030069 18 11 0,000 0,03102361 0,05708345 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,03102361 0,05703782 ! acrosome reaction GO:0007340 13 11 0,000 0,03102361 0,05699226 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03102361 0,05694677 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,0314123 0,05761427 ! extracellular structure organization GO:0043062 156 99 1,000 0,03261037 0,05976403 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,03321611 0,06082568 ! lactation GO:0007595 20 12 0,000 0,03379671 0,06183965 ! reproductive cellular process GO:0048610 14 12 0,000 0,03379671 0,06179049 ! tRNA modification GO:0006400 14 12 0,000 0,03379671 0,06174141 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03379671 0,06169241 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03379671 0,06164349 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03379671 0,06159464 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03379671 0,06154587 ! non-recombinational repair GO:0000726 19 12 0,000 0,03379671 0,06149718 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03379671 0,06144857 ! peroxisomal transport GO:0043574 21 12 0,000 0,03379671 0,06140003 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03379671 0,06135157 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03379671 0,06130318 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03379671 0,06125488 ! heart looping GO:0001947 15 12 0,000 0,03379671 0,06120664 ! palate development GO:0060021 15 12 0,000 0,03379671 0,06115849 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,03379671 0,06111041 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03379671 0,0610624 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03379671 0,06101447 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03379671 0,06096662 ! arginine metabolic process GO:0006525 13 12 0,000 0,03379671 0,06091884 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03379671 0,06087113 ! methionine metabolic process GO:0006555 13 12 0,000 0,03379671 0,0608235 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03379671 0,06077595 ! Golgi organization GO:0007030 18 12 0,000 0,03379671 0,06072847 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,03379671 0,06068106 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03379671 0,06063373 ! monoamine transport GO:0015844 13 12 0,000 0,03379671 0,06058647 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03379671 0,06053928 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03379671 0,06049217 ! L-amino acid transport GO:0015807 20 12 0,000 0,03379671 0,06044513 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03379671 0,06039816 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03379671 0,06035127 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03379671 0,06030445 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03379671 0,0602577 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03379671 0,06021103 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03379671 0,06016443 ! cerebellum development GO:0021549 13 12 0,000 0,03379671 0,06011789 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03379671 0,06007144 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03379671 0,06002505 ! histone methylation GO:0016571 15 12 0,000 0,03379671 0,05997873 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03379671 0,05993249 ! gland morphogenesis GO:0022612 23 12 0,000 0,03379671 0,05988632 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03379671 0,05984021 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03379671 0,05979418 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03379671 0,05974822 ! intestinal absorption GO:0050892 19 12 0,000 0,03379671 0,05970233 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03379671 0,05965651 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03379671 0,05961076 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03379671 0,05956509 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03379671 0,05951948 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03379671 0,05947394 ! microspike assembly GO:0030035 23 12 0,000 0,03379671 0,05942847 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03379671 0,05938307 ! response to cold GO:0009409 14 12 0,000 0,03379671 0,05933774 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,03656203 0,06414392 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03656203 0,06409503 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03656203 0,06404621 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03656203 0,06399747 ! water transport GO:0006833 17 13 0,000 0,03656203 0,0639488 GO:0042044|fluid transport, ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03656203 0,06390021 ! lipid localization GO:0010876 24 13 0,000 0,03656203 0,06385169 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03656203 0,06380324 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03656203 0,06375487 ! organelle fusion GO:0048284 28 13 0,000 0,03656203 0,06370657 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03656203 0,06365835 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03656203 0,06361019 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03656203 0,06356211 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03656203 0,06351411 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03656203 0,06346617 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03656203 0,06341831 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03656203 0,06337052 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03656203 0,0633228 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03656203 0,06327515 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03656203 0,06322758 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03656203 0,06318007 ! NAD metabolic process GO:0019674 21 13 0,000 0,03656203 0,06313264 ! exocrine system development GO:0035272 27 13 0,000 0,03656203 0,06308528 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03656203 0,06303799 ! bone mineralization GO:0030282 15 13 0,000 0,03656203 0,06299077 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03656203 0,06294362 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03656203 0,06289654 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03656203 0,06284953 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03656203 0,0628026 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03656203 0,06275573 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03656203 0,06270893 ! genitalia development GO:0048806 15 13 0,000 0,03656203 0,0626622 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03656203 0,06261554 ! cellular pigmentation GO:0033059 24 13 0,000 0,03656203 0,06256896 ! tissue regeneration GO:0042246 21 13 0,000 0,03656203 0,06252244 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,03656203 0,06247599 ! cofactor transport GO:0051181 19 13 0,000 0,03656203 0,0624296 ! NADP metabolic process GO:0006739 18 13 0,000 0,03656203 0,06238329 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03656203 0,06233705 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03656203 0,06229087 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03656203 0,06224476 ! gas transport GO:0015669 18 13 0,000 0,03656203 0,06219873 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03656203 0,06215275 ! regulation of axon extension GO:0030516 23 13 0,000 0,03656203 0,06210685 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03656203 0,06206102 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03656203 0,06201525 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03656203 0,06196955 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03656203 0,06192391 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03656203 0,06187835 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03656203 0,06183285 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,0393196 0,06644752 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,0393196 0,06639873 ! superoxide anion generation GO:0042554 18 14 0,000 0,0393196 0,06635002 ! neuron maturation GO:0042551 21 14 0,000 0,0393196 0,06630137 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,0393196 0,0662528 ! myotube differentiation GO:0014902 21 14 0,000 0,0393196 0,0662043 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,0393196 0,06615587 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,0393196 0,06610751 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,0393196 0,06605922 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,0393196 0,066011 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,0393196 0,06596286 ! gene silencing by RNA GO:0031047 20 14 0,000 0,0393196 0,06591478 ! response to cAMP GO:0051591 19 14 0,000 0,0393196 0,06586677 ! limbic system development GO:0021761 25 14 0,000 0,0393196 0,06581883 ! startle response GO:0001964 21 14 0,000 0,0393196 0,06577096 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,0393196 0,06572317 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,0393196 0,06567544 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,0393196 0,06562778 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,0393196 0,06558019 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,0393196 0,06553266 ! glycine metabolic process GO:0006544 22 14 0,000 0,0393196 0,06548521 ! pituitary gland development GO:0021983 23 14 0,000 0,0393196 0,06543783 ! cellular response to starvation GO:0009267 21 14 0,000 0,0393196 0,06539051 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,0393196 0,06534326 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,0393196 0,06529608 ! regulation of heart rate GO:0002027 23 14 0,000 0,0393196 0,06524897 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,0393196 0,06520193 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,0393196 0,06515495 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,0393196 0,06510805 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,0393196 0,06506121 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,0393196 0,06501443 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,0393196 0,06496773 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,0393196 0,06492109 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,0393196 0,06487452 ! axon cargo transport GO:0008088 27 14 0,000 0,0393196 0,06482801 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,0393196 0,06478157 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,0393196 0,0647352 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,0393196 0,06468889 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,0393196 0,06464266 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,0393196 0,06459648 ! mRNA splice site selection GO:0006376 26 14 0,000 0,0393196 0,06455037 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,0393196 0,06450433 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,0393196 0,06445836 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,0393196 0,06441245 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,0393196 0,0643666 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,0393196 0,06432082 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,0393196 0,06427511 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,0393196 0,06422946 ! muscle maintenance GO:0046716 19 14 0,000 0,0393196 0,06418387 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,0393196 0,06413835 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,0393196 0,0640929 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,0393196 0,0640475 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,0393196 0,06400218 ! cell killing GO:0001906 20 14 0,000 0,0393196 0,06395691 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,0393196 0,06391171 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,0393196 0,06386658 ! cilium assembly GO:0042384 20 14 0,000 0,0393196 0,06382151 ! peptide hormone secretion GO:0030072 23 14 0,000 0,0393196 0,0637765 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,04206943 0,06818864 ! positive regulation of cell size GO:0045793 20 15 0,000 0,04206943 0,06814062 ! metencephalon development GO:0022037 19 15 0,000 0,04206943 0,06809267 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,04206943 0,06804478 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,04206943 0,06799697 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,04206943 0,06794922 ! skin development GO:0043588 25 15 0,000 0,04206943 0,06790153 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,04206943 0,06785392 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,04206943 0,06780636 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,04206943 0,06775888 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,04206943 0,06771146 ! bile acid metabolic process GO:0008206 22 15 0,000 0,04206943 0,06766411 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,04206943 0,06761683 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,04206943 0,06756961 ! adult walking behavior GO:0007628 25 15 0,000 0,04206943 0,06752246 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,04206943 0,06747537 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,04206943 0,06742835 ! myoblast differentiation GO:0045445 27 15 0,000 0,04206943 0,06738139 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,04206943 0,0673345 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,04206943 0,06728768 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,04206943 0,06724092 ! cerebral cortex development GO:0021987 29 15 0,000 0,04206943 0,06719422 ! response to osmotic stress GO:0006970 22 15 0,000 0,04206943 0,06714759 ! vesicle coating GO:0006901 25 15 0,000 0,04206943 0,06710103 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,04206943 0,06705453 ! DNA integration GO:0015074 22 15 0,000 0,04206943 0,06700809 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,04206943 0,06696172 ! peptide secretion GO:0002790 27 15 0,000 0,04206943 0,06691541 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,04206943 0,06686917 ! regulation of vasodilation GO:0042312 24 15 0,000 0,04206943 0,06682299 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,04206943 0,06677687 ! neuron recognition GO:0008038 22 15 0,000 0,04206943 0,06673082 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,04206943 0,06668483 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,04206943 0,0666389 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,04206943 0,06659304 ! biomineral formation GO:0031214 18 15 0,000 0,04206943 0,06654724 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,04206943 0,0665015 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,04206943 0,06645583 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,04206943 0,06641021 ! dopamine metabolic process GO:0042417 30 15 0,000 0,04206943 0,06636467 ! organic cation transport GO:0015695 19 15 0,000 0,04206943 0,06631918 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,04206943 0,06627376 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,04206943 0,06622839 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,04206943 0,06618309 ! defense response to virus GO:0051607 27 15 0,000 0,04206943 0,06613786 ! peptide hormone processing GO:0016486 19 15 0,000 0,04206943 0,06609268 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,04206943 0,06604757 ! protein secretion GO:0009306 27 16 0,000 0,04481154 0,0703046 ! hormone secretion GO:0046879 25 16 0,000 0,04481154 0,07025668 ! bone remodeling GO:0046849 24 16 0,000 0,04481154 0,07020882 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,04481154 0,07016103 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04481154 0,0701133 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,04481154 0,07006563 ! glial cell development GO:0021782 24 16 0,000 0,04481154 0,07001804 ! patterning of blood vessels GO:0001569 24 16 0,000 0,04481154 0,0699705 ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,04481154 0,06992303 ! protein polyubiquitination GO:0000209 26 16 0,000 0,04481154 0,06987563 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,04481154 0,06982828 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,04481154 0,06978101 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,04481154 0,06973379 ! fructose metabolic process GO:0006000 20 16 0,000 0,04481154 0,06968665 ! regulation of protein binding GO:0043393 27 16 0,000 0,04481154 0,06963956 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,04481154 0,06959254 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,04481154 0,06954558 ! protein export from nucleus GO:0006611 24 16 0,000 0,04481154 0,06949868 ! negative regulation of immune response GO:0050777 28 16 0,000 0,04481154 0,06945185 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,04481154 0,06940508 ! DNA replication initiation GO:0006270 25 16 0,000 0,04481154 0,06935838 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,04481154 0,06931173 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,04481154 0,06926515 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,04481154 0,06921864 ! diencephalon development GO:0021536 25 16 0,000 0,04481154 0,06917218 ! neural crest cell migration GO:0001755 24 16 0,000 0,04481154 0,06912579 ! G1 phase GO:0051318 27 16 0,000 0,04481154 0,06907946 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,04481154 0,06903319 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,04481154 0,06898698 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,04481154 0,06894083 ! steroid catabolic process GO:0006706 22 16 0,000 0,04481154 0,06889475 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,04481154 0,06884873 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,04481154 0,06880277 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,04481154 0,06875687 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,04481154 0,06871103 ! sperm-egg recognition GO:0035036 16 16 0,000 0,04481154 0,06866526 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,04481154 0,06861954 ! nerve development GO:0021675 18 16 0,000 0,04481154 0,06857388 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,04481154 0,06852829 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,04481154 0,06848276 ! negative regulation of translation GO:0017148 22 16 0,000 0,04481154 0,06843728 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04754597 0,07256518 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04754597 0,07251706 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04754597 0,072469 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,04754597 0,07242101 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04754597 0,07237308 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04754597 0,07232521 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04754597 0,07227741 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04754597 0,07222967 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04754597 0,07218199 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04754597 0,07213438 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04754597 0,07208683 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04754597 0,07203934 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04754597 0,07199192 ! memory GO:0007613 25 17 0,000 0,04754597 0,07194455 ! keratinization GO:0031424 17 17 0,000 0,04754597 0,07189725 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04754597 0,07185001 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,04754597 0,07180284 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04754597 0,07175572 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04754597 0,07170867 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,04754597 0,07166168 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04754597 0,07161475 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04754597 0,07156788 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,04754597 0,07152107 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04754597 0,07147433 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,04754597 0,07142764 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04754597 0,07138102 ! membrane budding GO:0006900 29 17 0,000 0,04754597 0,07133446 ! heme metabolic process GO:0042168 27 17 0,000 0,04754597 0,07128795 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04754597 0,07124151 ! body fluid secretion GO:0007589 27 17 0,000 0,04754597 0,07119513 ! stem cell differentiation GO:0048863 36 17 0,000 0,04754597 0,07114881 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04754597 0,07110255 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04754597 0,07105635 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04754597 0,07101021 ! sensory perception of pain GO:0019233 23 17 0,000 0,04754597 0,07096413 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04754597 0,07091811 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04754597 0,07087215 ! synaptogenesis GO:0007416 24 17 0,000 0,04754597 0,07082624 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,04754597 0,0707804 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04754597 0,07073462 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04754597 0,07068889 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04754597 0,07064323 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04754597 0,07059762 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04754597 0,07055208 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04754597 0,07050659 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04754597 0,07046116 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04754597 0,07041579 ! positive regulation of translation GO:0045727 28 18 0,000 0,05027272 0,07440621 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,05027272 0,07435836 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,05027272 0,07431057 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,05027272 0,07426284 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,05027272 0,07421518 ! cAMP metabolic process GO:0046058 33 18 0,000 0,05027272 0,07416757 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,05027272 0,07412003 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,05027272 0,07407255 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,05027272 0,07402513 ! axis specification GO:0009798 26 18 0,000 0,05027272 0,07397776 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,05027272 0,07393046 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,05027272 0,07388322 ! pancreas development GO:0031016 26 18 0,000 0,05027272 0,07383605 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,05027272 0,07378893 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,05027272 0,07374187 ! glutamine metabolic process GO:0006541 23 18 0,000 0,05027272 0,07369487 ! response to retinoic acid GO:0032526 25 18 0,000 0,05027272 0,07364793 ! pigmentation during development GO:0048066 31 18 0,000 0,05027272 0,07360105 ! central nervous system neuron development GO:0021954 30 18 0,000 0,05027272 0,07355423 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,05027272 0,07350747 ! fucose metabolic process GO:0006004 26 18 0,000 0,05027272 0,07346077 ! response to fungus GO:0009620 19 18 0,000 0,05027272 0,07341412 ! peptide cross-linking GO:0018149 31 18 0,000 0,05027272 0,07336754 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,05027272 0,07332102 ! heart process GO:0003015 27 18 0,000 0,05027272 0,07327455 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,05027272 0,07322815 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,05027272 0,0731818 ! visual learning GO:0008542 35 18 0,000 0,05027272 0,07313551 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,05027272 0,07308928 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,05027272 0,07304311 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,05027272 0,072997 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,05027272 0,07295094 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,05027272 0,07290495 ! vitamin transport GO:0051180 24 18 0,000 0,05027272 0,07285901 ! hormone transport GO:0009914 27 18 0,000 0,05027272 0,07281313 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,05027272 0,0727673 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,05027272 0,07272154 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,05027272 0,07267583 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,05027272 0,07263018 ! cell-cell recognition GO:0009988 20 18 0,000 0,05027272 0,07258459 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,05027272 0,07253905 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,05027272 0,07249357 ! regulation of glucose import GO:0046324 21 18 0,000 0,05027272 0,07244815 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,05027272 0,07240278 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,05027272 0,07235748 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,05027272 0,07231222 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,05299182 0,07617574 ! positive regulation of ossification GO:0045778 30 19 0,000 0,05299182 0,07612816 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,05299182 0,07608063 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,05299182 0,07603317 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,05299182 0,07598577 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,05299182 0,07593843 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,05299182 0,07589114 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,05299182 0,07584392 ! regeneration GO:0031099 32 19 0,000 0,05299182 0,07579675 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,05299182 0,07574964 ! response to alkaloid GO:0043279 32 19 0,000 0,05299182 0,07570259 ! sensory perception of taste GO:0050909 23 19 0,000 0,05299182 0,0756556 ! smooth muscle contraction GO:0006939 36 19 0,000 0,05299182 0,07560867 ! peroxisome organization GO:0007031 29 19 0,000 0,05299182 0,0755618 ! digestive system process GO:0022600 30 19 0,000 0,05299182 0,07551498 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,05299182 0,07546822 ! response to vitamin A GO:0033189 26 19 0,000 0,05299182 0,07542152 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,05299182 0,07537488 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,05299182 0,07532829 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,05299182 0,07528176 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,05299182 0,07523529 ! response to starvation GO:0042594 30 19 0,000 0,05299182 0,07518888 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,05299182 0,07514253 ! plasma membrane fusion GO:0045026 23 19 0,000 0,05299182 0,07509623 ! cytolysis GO:0019835 20 19 0,000 0,05299182 0,07504999 ! renal system process GO:0003014 35 19 0,000 0,05299182 0,0750038 ! vasodilation GO:0042311 33 19 0,000 0,05299182 0,07495767 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,05299182 0,0749116 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,05299182 0,07486559 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,05299182 0,07481963 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,05299182 0,07477373 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,05299182 0,07472788 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,05299182 0,07468209 ! sarcomere organization GO:0045214 23 19 0,000 0,05299182 0,07463636 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,05299182 0,07459068 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,05299182 0,07454506 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,05299182 0,0744995 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,05299182 0,07445399 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,05299182 0,07440853 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,05299182 0,07436313 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,05299182 0,07431779 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,05299182 0,0742725 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,05570329 0,07802531 ! iron ion transport GO:0006826 37 20 0,000 0,05570329 0,07797782 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,05570329 0,07793039 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,05570329 0,07788301 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,05570329 0,0778357 ! response to vitamin GO:0033273 29 20 0,000 0,05570329 0,07778844 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,05570329 0,07774124 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,05570329 0,07769409 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,05570329 0,07764701 ! spinal cord development GO:0021510 31 20 0,000 0,05570329 0,07759998 ! response to ethanol GO:0045471 37 20 0,000 0,05570329 0,077553 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,05570329 0,07750609 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,05570329 0,07745923 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,05570329 0,07741242 ! chromosome condensation GO:0030261 31 20 0,000 0,05570329 0,07736568 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,05570329 0,07731899 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,05570329 0,07727235 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,05570329 0,07722577 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,05570329 0,07717925 ! pallium development GO:0021543 38 20 0,000 0,05570329 0,07713279 ! DNA modification GO:0006304 28 20 0,000 0,05570329 0,07708638 ! collagen fibril organization GO:0030199 45 20 0,000 0,05570329 0,07704002 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,05570329 0,07699373 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,05570329 0,07694748 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,05570329 0,0769013 ! collagen catabolic process GO:0030574 25 20 0,000 0,05570329 0,07685516 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,05570329 0,07680909 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,05570329 0,07676307 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,05570329 0,0767171 ! alditol metabolic process GO:0019400 24 20 0,000 0,05570329 0,07667119 ! actin filament-based movement GO:0030048 34 20 0,000 0,05570329 0,07662533 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,05840715 0,08029674 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05840715 0,08024877 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,05840715 0,08020086 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05840715 0,08015301 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05840715 0,08010521 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05840715 0,08005747 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05840715 0,08000979 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,05840715 0,07996217 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,05840715 0,0799146 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,05840715 0,07986709 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05840715 0,07981963 ! vesicle docking GO:0048278 27 21 0,000 0,05840715 0,07977223 ! phototransduction GO:0007602 25 21 0,000 0,05840715 0,07972489 ! dendrite development GO:0016358 35 21 0,000 0,05840715 0,0796776 ! visual behavior GO:0007632 39 21 0,000 0,05840715 0,07963037 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,05840715 0,0795832 ! ovarian follicle development GO:0001541 30 21 0,000 0,05840715 0,07953608 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,05840715 0,07948902 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05840715 0,07944201 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,05840715 0,07939506 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,05840715 0,07934816 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05840715 0,07930132 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,05840715 0,07925454 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,05840715 0,07920781 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05840715 0,07916113 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05840715 0,07911451 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,05840715 0,07906795 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,05840715 0,07902144 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05840715 0,07897498 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,05840715 0,07892858 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05840715 0,07888223 ! fatty acid transport GO:0015908 30 21 0,000 0,05840715 0,07883594 ! immunoglobulin production GO:0002377 33 21 0,000 0,05840715 0,0787897 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05840715 0,07874352 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,05840715 0,07869739 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05840715 0,07865131 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05840715 0,07860529 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05840715 0,07855932 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,05840715 0,07851341 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05840715 0,07846755 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05840715 0,07842174 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05840715 0,07837599 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05840715 0,07833029 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05840715 0,07828464 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05840715 0,07823905 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05840715 0,0781935 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05840715 0,07814802 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,06110342 0,08170806 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,06110342 0,08166059 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,06110342 0,08161317 ! viral genome replication GO:0019079 29 22 0,000 0,06110342 0,0815658 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,06110342 0,08151849 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,06110342 0,08147123 ! leukocyte adhesion GO:0007159 38 22 0,000 0,06110342 0,08142403 ! molting cycle process GO:0022404 40 22 0,000 0,06110342 0,08137688 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,06110342 0,08132979 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,06110342 0,08128275 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,06110342 0,08123576 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,06110342 0,08118883 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,06110342 0,08114196 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,06110342 0,08109514 ! lysosome organization GO:0007040 37 22 0,000 0,06110342 0,08104837 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,06110342 0,08100166 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,06110342 0,080955 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,06110342 0,08090839 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,06110342 0,08086184 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,06110342 0,08081534 ! membrane depolarization GO:0051899 35 22 0,000 0,06110342 0,08076889 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,06110342 0,0807225 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,06110342 0,08067616 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,06110342 0,08062987 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,06110342 0,08058364 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,06110342 0,08053746 ! neural tube closure GO:0001843 33 22 0,000 0,06110342 0,08049134 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,06110342 0,08044526 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,06379213 0,08393701 ! neuron fate commitment GO:0048663 32 23 0,000 0,06379213 0,08388902 ! embryonic pattern specification GO:0009880 31 23 0,000 0,06379213 0,08384108 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,06379213 0,0837932 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,06379213 0,08374538 ! vesicle targeting GO:0006903 32 23 0,000 0,06379213 0,0836976 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,06379213 0,08364989 ! osteoblast differentiation GO:0001649 40 23 0,000 0,06379213 0,08360222 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,06379213 0,08355461 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,06379213 0,08350706 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,06379213 0,08345956 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,06379213 0,08341211 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,06379213 0,08336471 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,06379213 0,08331738 ! cell fate determination GO:0001709 45 23 0,000 0,06379213 0,08327009 ! pentose metabolic process GO:0019321 31 23 0,000 0,06379213 0,08322286 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,06379213 0,08317568 ! spermatid development GO:0007286 33 23 0,000 0,06379213 0,08312855 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,06379213 0,08308148 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,06379213 0,08303446 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,06379213 0,0829875 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,06379213 0,08294059 ! telomere organization GO:0032200 32 23 0,000 0,06379213 0,08289373 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,06379213 0,08284692 ! regulation of amine transport GO:0051952 38 23 0,000 0,06379213 0,08280017 ! liver development GO:0001889 40 23 0,000 0,06379213 0,08275347 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,06647329 0,08618296 ! initiation of viral infection GO:0019059 42 24 0,000 0,06647329 0,08613441 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,06647329 0,08608591 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,06647329 0,08603746 ! superoxide metabolic process GO:0006801 32 24 0,000 0,06647329 0,08598907 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,06647329 0,08594074 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,06647329 0,08589245 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,06647329 0,08584423 ! sperm motility GO:0030317 27 24 0,000 0,06647329 0,08579605 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,06647329 0,08574794 ! vacuole organization GO:0007033 39 24 0,000 0,06647329 0,08569987 ! neural crest cell development GO:0014032 39 24 0,000 0,06647329 0,08565186 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,06647329 0,0856039 ! primary neural tube formation GO:0014020 35 24 0,000 0,06647329 0,085556 ! negative regulation of cell development GO:0010721 56 24 0,000 0,06647329 0,08550815 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,06647329 0,08546035 ! base-excision repair GO:0006284 31 24 0,000 0,06647329 0,08541261 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,06647329 0,08536492 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,06647329 0,08531728 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,06647329 0,0852697 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,06647329 0,08522217 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,06647329 0,08517469 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,06914693 0,08855119 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,06914693 0,08850191 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,06914693 0,08845269 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,06914693 0,08840352 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,06914693 0,08835441 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,06914693 0,08830535 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,06914693 0,08825634 ! peptide transport GO:0015833 43 25 0,000 0,06914693 0,08820739 ! male gonad development GO:0008584 33 25 0,000 0,06914693 0,0881585 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,06914693 0,08810966 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,06914693 0,08806087 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,06914693 0,08801214 ! phospholipid transport GO:0015914 35 25 0,000 0,06914693 0,08796346 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,06914693 0,08791483 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,06914693 0,08786626 ! detection of light stimulus GO:0009583 30 25 0,000 0,06914693 0,08781774 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,06914693 0,08776928 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,06914693 0,08772087 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,07181306 0,09105294 ! translational initiation GO:0006413 43 26 0,000 0,07181306 0,09100277 ! regulation of pH GO:0006885 36 26 0,000 0,07181306 0,09095266 ! circadian rhythm GO:0007623 42 26 0,000 0,07181306 0,09090261 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,07181306 0,0908526 ! post-embryonic development GO:0009791 42 26 0,000 0,07181306 0,09080266 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,07181306 0,09075277 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,07181306 0,09070293 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,07181306 0,09065315 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,07181306 0,09060342 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,07181306 0,09055375 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,07181306 0,09050413 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,07181306 0,09045456 ! regulation of coagulation GO:0050818 39 26 0,000 0,07181306 0,09040505 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,07447171 0,09370072 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,07447171 0,09364949 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,07447171 0,09359832 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,07447171 0,0935472 ! membrane docking GO:0022406 39 27 0,000 0,07447171 0,09349614 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,07447171 0,09344513 ! catechol metabolic process GO:0009712 43 27 0,000 0,07447171 0,09339418 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,07447171 0,09334328 ! acute-phase response GO:0006953 42 27 0,000 0,07447171 0,09329244 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,07447171 0,09324166 ! myofibril assembly GO:0030239 36 27 0,000 0,07447171 0,09319093 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,07447171 0,09314025 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,07447171 0,09308963 ! natural killer cell activation GO:0030101 35 27 0,000 0,07447171 0,09303907 ! lipid oxidation GO:0034440 38 27 0,000 0,07447171 0,09298856 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,07447171 0,0929381 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,07447171 0,0928877 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,07447171 0,09283736 ! gene silencing GO:0016458 41 27 0,000 0,07447171 0,09278707 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,07712289 0,09603825 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,07712289 0,09598628 ! phenol metabolic process GO:0018958 44 28 0,000 0,07712289 0,09593437 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,07712289 0,09588251 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,07712289 0,09583071 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,07712289 0,09577897 ! cell junction assembly GO:0034329 56 28 0,000 0,07712289 0,09572728 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,07712289 0,09567564 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,07712289 0,09562407 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,07712289 0,09557255 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,07712289 0,09552108 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,07712289 0,09546967 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,07712289 0,09541831 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,07712289 0,09536701 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,07712289 0,09531577 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,07712289 0,09526458 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,07712289 0,09521344 ! mesoderm formation GO:0001707 46 28 0,000 0,07712289 0,09516236 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,07712289 0,09511134 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,07712289 0,09506037 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,07712289 0,09500945 ! BMP signaling pathway GO:0030509 40 28 0,000 0,07712289 0,09495859 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,07712289 0,09490778 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,07712289 0,09485703 ! neural tube formation GO:0001841 41 28 0,000 0,07712289 0,09480633 ! placenta development GO:0001890 37 28 0,000 0,07712289 0,09475569 ! regulation of innate immune response GO:0045088 38 29 0,000 0,07976663 0,09795155 ! ovulation cycle process GO:0022602 41 29 0,000 0,07976663 0,09789928 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,07976663 0,09784707 ! protein targeting to membrane GO:0006612 53 29 0,000 0,07976663 0,09779491 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,07976663 0,09774281 ! muscle cell development GO:0055001 38 29 0,000 0,07976663 0,09769076 ! formation of primary germ layer GO:0001704 48 29 0,000 0,07976663 0,09763877 ! telencephalon development GO:0021537 52 29 0,000 0,07976663 0,09758683 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,07976663 0,09753495 ! eye morphogenesis GO:0048592 51 29 0,000 0,07976663 0,09748313 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,07976663 0,09743136 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,08240295 0,10059808 ! collagen metabolic process GO:0032963 40 30 0,000 0,08240295 0,10054471 ! organic anion transport GO:0015711 51 30 0,000 0,08240295 0,1004914 ! cholesterol transport GO:0030301 46 30 0,000 0,08240295 0,10043815 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,08240295 0,10038495 ! spliceosome assembly GO:0000245 49 30 0,000 0,08240295 0,10033181 ! spindle organization GO:0007051 37 30 0,000 0,08240295 0,10027872 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,08240295 0,10022569 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,08240295 0,10017272 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,08240295 0,1001198 ! ceramide metabolic process GO:0006672 43 30 0,000 0,08240295 0,10006694 ! ovulation cycle GO:0042698 43 30 0,000 0,08240295 0,10001413 ! hindbrain development GO:0030902 45 30 0,000 0,08240295 0,09996138 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,08240295 0,09990869 ! adult locomotory behavior GO:0008344 47 30 0,000 0,08240295 0,09985605 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,08240295 0,09980347 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,08240295 0,09975094 ! response to heat GO:0009408 41 30 0,000 0,08240295 0,09969847 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,08240295 0,09964605 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,08240295 0,09959368 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,08503187 0,10271706 ! negative regulation of secretion GO:0051048 49 31 0,000 0,08503187 0,10266314 ! glial cell differentiation GO:0010001 55 31 0,000 0,08503187 0,10260928 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,08503187 0,10255547 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,08503187 0,10250172 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,08503187 0,10244803 ! odontogenesis GO:0042476 50 31 0,000 0,08503187 0,10239439 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,08503187 0,10234081 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,08503187 0,10228729 ! metanephros development GO:0001656 58 31 0,000 0,08503187 0,10223382 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,08503187 0,1021804 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,08503187 0,10212704 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,08503187 0,10207374 ! cell fate specification GO:0001708 37 31 0,000 0,08503187 0,1020205 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,08503187 0,1019673 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,08503187 0,10191417 ! RNA modification GO:0009451 40 31 0,000 0,08503187 0,10186109 ! regulation of muscle development GO:0048634 48 32 0,000 0,0876534 0,10494681 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,0876534 0,10489221 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,0876534 0,10483766 ! meiosis I GO:0007127 52 32 0,000 0,0876534 0,10478317 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,0876534 0,10472874 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,0876534 0,10467436 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,0876534 0,10462004 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,0876534 0,10456578 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,0876534 0,10451157 ! cytokine production GO:0001816 44 32 0,000 0,0876534 0,10445742 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,0876534 0,10440333 ! vesicle localization GO:0051648 47 32 0,000 0,0876534 0,10434929 ! RNA export from nucleus GO:0006405 44 33 0,000 0,09026757 0,1074058 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,09026757 0,10735027 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,09026757 0,10729479 ! sister chromatid segregation GO:0000819 46 33 0,000 0,09026757 0,10723937 ! ear morphogenesis GO:0042471 42 33 0,000 0,09026757 0,10718401 ! actomyosin structure organization GO:0031032 43 33 0,000 0,09026757 0,1071287 ! cell junction organization GO:0034330 63 33 0,000 0,09026757 0,10707345 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,09026757 0,10701826 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,09026757 0,10696312 ! nucleus organization GO:0006997 49 33 0,000 0,09026757 0,10690804 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,09026757 0,10685302 ! positive regulation of cell development GO:0010720 54 33 0,000 0,09026757 0,10679806 ! lipid homeostasis GO:0055088 55 33 0,000 0,09026757 0,10674315 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,09026757 0,10668829 ! regulation of proteolysis GO:0030162 50 33 0,000 0,09026757 0,1066335 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,09026757 0,10657876 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,09026757 0,10652407 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,09026757 0,10646945 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,09026757 0,10641487 ! mRNA catabolic process GO:0006402 48 34 0,000 0,09287441 0,10943193 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,09287441 0,1093759 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,09287441 0,10931993 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,09287441 0,10926401 ! feeding behavior GO:0007631 45 34 0,000 0,09287441 0,10920815 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,09287441 0,10915234 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,09287441 0,1090966 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,09287441 0,10904091 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,09287441 0,10898527 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,09287441 0,1089297 ! neuron migration GO:0001764 46 34 0,000 0,09287441 0,10887418 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,09287441 0,10881871 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,09287441 0,10876331 ! aerobic respiration GO:0009060 47 34 0,000 0,09287441 0,10870796 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,09287441 0,10865266 ! embryonic organ development GO:0048568 45 34 0,000 0,09287441 0,10859743 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,09287441 0,10854224 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,09547392 0,11152362 ! Notch signaling pathway GO:0007219 56 35 0,000 0,09547392 0,11146701 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,09547392 0,11141046 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,09547392 0,11135396 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,09547392 0,11129752 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,09547392 0,11124114 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,09547392 0,11118482 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,09547392 0,11112855 ! glycogen metabolic process GO:0005977 48 35 0,000 0,09547392 0,11107234 ! pigment metabolic process GO:0042440 61 35 0,000 0,09547392 0,11101618 ! protein homooligomerization GO:0051260 52 35 0,000 0,09547392 0,11096009 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,09806613 0,1139152 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,09806613 0,1138577 ! organic ether metabolic process GO:0018904 46 36 0,000 0,09806613 0,11380025 ! neural tube development GO:0021915 50 36 0,000 0,09806613 0,11374286 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,09806613 0,11368553 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,09806613 0,11362826 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,09806613 0,11357105 ! glucan metabolic process GO:0044042 49 36 0,000 0,09806613 0,11351389 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,10065106 0,1164474 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,10065106 0,11638886 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,10065106 0,11633037 ! learning GO:0007612 67 37 0,000 0,10065106 0,11627194 ! ion transmembrane transport GO:0034220 56 37 0,000 0,10065106 0,11621357 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,10065106 0,11615526 ! regulation of protein secretion GO:0050708 51 37 0,000 0,10065106 0,11609701 ! amino acid activation GO:0043038 52 37 0,000 0,10065106 0,11603882 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,10065106 0,11598068 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,10322873 0,11889138 ! gliogenesis GO:0042063 71 38 0,000 0,10322873 0,11883187 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,10322873 0,11877242 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,10322873 0,11871304 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,10322873 0,11865371 ! phagocytosis GO:0006909 60 38 0,000 0,10322873 0,11859444 ! mesenchymal cell development GO:0014031 64 38 0,000 0,10322873 0,11853524 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,10322873 0,11847609 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,10579916 0,12136562 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,10579916 0,12130512 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,10579916 0,12124468 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,10579916 0,12118429 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,10579916 0,12112397 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,10579916 0,12106371 ! male sex differentiation GO:0046661 53 39 0,000 0,10579916 0,12100351 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,10579916 0,12094337 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,10579916 0,12088329 ! JNK cascade GO:0007254 54 39 0,000 0,10579916 0,12082327 ! cell growth GO:0016049 61 39 0,000 0,10579916 0,12076331 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,10836237 0,1236277 ! response to calcium ion GO:0051592 58 40 0,000 0,10836237 0,12356641 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,10836237 0,12350517 ! regulation of tube size GO:0035150 60 40 0,000 0,10836237 0,123444 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,10836237 0,12338289 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,10836237 0,12332184 ! peptide metabolic process GO:0006518 56 40 0,000 0,10836237 0,12326085 ! inner ear development GO:0048839 57 40 0,000 0,10836237 0,12319992 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,10836237 0,12313905 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,10836237 0,12307824 ! B cell differentiation GO:0030183 62 40 0,000 0,10836237 0,12301749 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,10836237 0,1229568 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,10836237 0,12289617 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,10836237 0,12283561 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,11091837 0,12567106 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,11091837 0,12560919 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,11091837 0,12554737 ! glucose transport GO:0015758 52 41 0,000 0,11091837 0,12548562 ! striated muscle contraction GO:0006941 62 41 0,000 0,11091837 0,12542392 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,11091837 0,12536229 ! biopolymer methylation GO:0043414 62 41 0,000 0,11091837 0,12530072 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,11091837 0,1252392 ! mitochondrial transport GO:0006839 60 42 0,000 0,1134672 0,12805425 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,1134672 0,12799145 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,1134672 0,12792871 ! cellular component disassembly GO:0022411 64 42 0,000 0,1134672 0,12786603 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,1134672 0,12780341 ! hexose transport GO:0008645 54 42 0,000 0,1134672 0,12774085 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,1134672 0,12767836 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,1134672 0,12761592 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,1134672 0,12755355 ! excretion GO:0007588 63 42 0,000 0,1134672 0,12749124 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,1134672 0,12742898 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,1134672 0,12736679 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,1134672 0,12730466 ! leukocyte migration GO:0050900 60 43 0,000 0,11600887 0,13009283 ! neuromuscular process GO:0050905 79 43 0,000 0,11600887 0,13002943 ! activation of caspase activity GO:0006919 65 43 0,000 0,11600887 0,12996609 ! tRNA processing GO:0008033 49 43 0,000 0,11600887 0,12990282 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,11600887 0,12983961 ! vesicle organization GO:0016050 79 43 0,000 0,11600887 0,12977645 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,11600887 0,12971336 ! methylation GO:0032259 64 43 0,000 0,11600887 0,12965034 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,11854339 0,13241855 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,11854339 0,13235427 ! glycolysis GO:0006096 53 44 0,000 0,11854339 0,13229005 ! regulation of ion transport GO:0043269 57 44 0,000 0,11854339 0,13222589 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,11854339 0,1321618 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,11854339 0,13209777 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,11854339 0,1320338 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,11854339 0,13196989 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,11854339 0,13190604 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,11854339 0,13184226 ! RNA catabolic process GO:0006401 64 45 0,000 0,12107079 0,13458812 ! positive regulation of defense response GO:0031349 59 45 0,000 0,12107079 0,1345231 ! regulation of translational initiation GO:0006446 64 45 0,000 0,12107079 0,13445815 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,12107079 0,13439325 ! cell recognition GO:0008037 58 45 0,000 0,12107079 0,13432842 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,12359109 0,13705859 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,12359109 0,13699253 ! cell redox homeostasis GO:0045454 63 46 0,000 0,12359109 0,13692654 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,12359109 0,13686062 ! regulation of ossification GO:0030278 71 46 0,000 0,12359109 0,13679476 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,12359109 0,13672896 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,12610431 0,13944226 ! viral infectious cycle GO:0019058 71 47 0,000 0,12610431 0,13937525 ! endocrine system development GO:0035270 83 47 0,000 0,12610431 0,13930831 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,12610431 0,13924143 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,12610431 0,13917462 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,12610431 0,13910787 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,12610431 0,13904118 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,12610431 0,13897456 ! chloride transport GO:0006821 67 48 0,000 0,12861046 0,14166861 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,12861046 0,14160079 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,12861046 0,14153304 ! response to temperature stimulus GO:0009266 62 48 0,000 0,12861046 0,14146536 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,12861046 0,14139773 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,12861046 0,14133018 ! gastrulation GO:0007369 73 48 0,000 0,12861046 0,14126268 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,12861046 0,14119525 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,12861046 0,14112789 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,12861046 0,14106059 ! regulation of endocytosis GO:0030100 63 48 0,000 0,12861046 0,14099335 ! nuclear export GO:0051168 69 48 0,000 0,12861046 0,14092618 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,12861046 0,14085908 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,13110957 0,14352785 ! sensory perception of smell GO:0007608 61 49 0,000 0,13110957 0,14345957 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,13110957 0,14339135 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,13110957 0,1433232 ! RNA elongation GO:0006354 62 49 0,000 0,13110957 0,14325511 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,13110957 0,14318709 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,13110957 0,14311913 ! regulation of actin filament length GO:0030832 72 50 0,000 0,13360165 0,14577031 ! ear development GO:0043583 72 50 0,000 0,13360165 0,14570119 ! membrane fusion GO:0006944 80 50 0,000 0,13360165 0,14563214 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,13360165 0,14556315 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,13360165 0,14549423 ! proton transport GO:0015992 75 50 0,000 0,13360165 0,14542537 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,13360165 0,14535658 ! positive regulation of secretion GO:0051047 71 51 0,000 0,13608674 0,1479903 ! hydrogen transport GO:0006818 77 51 0,000 0,13608674 0,14792036 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,13608674 0,14785049 ! adult behavior GO:0030534 80 51 0,000 0,13608674 0,14778068 ! regulation of cellular component size GO:0032535 74 52 0,000 0,13856483 0,15040071 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,13856483 0,15032977 ! establishment of organelle localization GO:0051656 85 52 0,000 0,13856483 0,15025889 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,14103596 0,15286649 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,14103596 0,15279449 ! kidney development GO:0001822 90 53 0,000 0,14103596 0,15272255 ! single fertilization GO:0007338 59 53 0,000 0,14103596 0,15265068 ! cell projection assembly GO:0030031 76 53 0,000 0,14103596 0,15257888 ! amino acid transport GO:0006865 84 54 0,000 0,14350014 0,15517175 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,14350014 0,15509883 ! regulation of mitosis GO:0007088 84 54 0,000 0,14350014 0,15502598 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,14350014 0,1549532 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,14350014 0,15488049 ! DNA catabolic process GO:0006308 67 54 0,000 0,14350014 0,15480784 ! detection of external stimulus GO:0009581 66 54 0,000 0,14350014 0,15473526 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,14350014 0,15466275 ! exocytosis GO:0006887 74 55 0,000 0,14595739 0,15723747 ! mesoderm development GO:0007498 76 55 0,000 0,14595739 0,15716386 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,14595739 0,15709031 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,14595739 0,15701684 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,14840773 0,15957821 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,14840773 0,15950364 ! carbohydrate transport GO:0008643 74 57 0,000 0,15085119 0,16205405 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,15085119 0,1619784 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,15085119 0,16190281 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,15085119 0,1618273 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,15085119 0,16175185 ! camera-type eye development GO:0043010 88 57 0,000 0,15085119 0,16167648 ! secondary metabolic process GO:0019748 84 57 0,000 0,15085119 0,16160118 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,15328777 0,16413495 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,15328777 0,16405857 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,15328777 0,16398226 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,1557175 0,16650407 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,1557175 0,16642669 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,15814039 0,16893772 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,15814039 0,16885929 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,15814039 0,16878093 ! regulation of heart contraction GO:0008016 91 60 0,000 0,15814039 0,16870265 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,15814039 0,16862444 ! fertilization GO:0009566 68 60 0,000 0,15814039 0,1685463 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,16055648 0,1710421 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,16055648 0,17096291 ! urogenital system development GO:0001655 101 61 0,000 0,16055648 0,1708838 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,16055648 0,17080476 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,16055648 0,1707258 ! extracellular matrix organization GO:0030198 103 61 0,000 0,16055648 0,1706469 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,16055648 0,17056808 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,16055648 0,17048933 ! amine catabolic process GO:0009310 90 62 0,000 0,16296576 0,17296781 ! neurotransmitter transport GO:0006836 81 62 0,000 0,16296576 0,17288803 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,16296576 0,17280832 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,16296576 0,17272869 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,16296576 0,17264913 ! organelle localization GO:0051640 96 62 0,000 0,16296576 0,17256964 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,16536827 0,17503315 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,16776402 0,17748724 ! appendage morphogenesis GO:0035107 93 64 0,000 0,16776402 0,17740563 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,16776402 0,17732411 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,16776402 0,17724265 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,16776402 0,17716127 ! hexose catabolic process GO:0019320 82 64 0,000 0,16776402 0,17707997 ! regulation of caspase activity GO:0043281 97 65 0,000 0,17015303 0,17951926 ! appendage development GO:0048736 94 65 0,000 0,17015303 0,17943695 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,17015303 0,17935471 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,17015303 0,17927255 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,17015303 0,17919047 ! defense response to bacterium GO:0042742 73 65 0,000 0,17015303 0,17910846 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,17015303 0,17902652 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,17015303 0,17894466 ! activation of immune response GO:0002253 83 65 0,000 0,17015303 0,17886288 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,17253532 0,18128426 ! antigen processing and presentation GO:0019882 96 66 0,000 0,17253532 0,18120148 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,17253532 0,18111878 ! regulation of immune effector process GO:0002697 101 66 0,000 0,17253532 0,18103615 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,17491091 0,1834451 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,17491091 0,18336149 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,17491091 0,18327795 ! acute inflammatory response GO:0002526 92 68 0,000 0,17727982 0,18567558 ! learning or memory GO:0007611 123 68 0,000 0,17727982 0,18559107 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,17727982 0,18550663 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,17727982 0,18542227 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,17727982 0,18533799 ! rhythmic process GO:0048511 105 68 0,000 0,17727982 0,18525378 ! inorganic anion transport GO:0015698 93 68 0,000 0,17727982 0,18516965 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,17964205 0,18755185 ! response to drug GO:0042493 108 69 0,000 0,17964205 0,18746675 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,17964205 0,18738173 ! response to metal ion GO:0010038 103 70 0,000 0,18199764 0,18975276 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,18199764 0,18966678 ! humoral immune response GO:0006959 86 70 0,000 0,18199764 0,18958088 ! eye development GO:0001654 111 70 0,000 0,18199764 0,18949506 ! amine transport GO:0015837 101 70 0,000 0,18199764 0,18940931 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,18199764 0,18932365 ! muscle cell differentiation GO:0042692 104 71 0,000 0,18434661 0,19168047 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,18434661 0,19159385 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,18434661 0,19150731 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,18434661 0,19142085 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,18434661 0,19133447 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,18434661 0,19124817 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,18668896 0,19359089 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,18668896 0,19350365 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,18668896 0,19341649 ! regulation of blood pressure GO:0008217 107 73 0,000 0,18902471 0,19574824 ! tube morphogenesis GO:0035239 118 73 0,000 0,18902471 0,19566015 ! mitochondrion organization GO:0007005 104 73 0,000 0,18902471 0,19557213 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,18902471 0,19548419 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,1913539 0,19780403 ! digestion GO:0007586 97 74 0,000 0,1913539 0,19771517 ! protein import into nucleus GO:0006606 118 74 0,000 0,1913539 0,19762639 ! blood coagulation GO:0007596 116 75 0,000 0,19367653 0,19993537 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,19367653 0,19984568 ! regulation of ligase activity GO:0051340 114 75 0,000 0,19367653 0,19975606 ! nuclear import GO:0051170 121 75 0,000 0,19367653 0,19966652 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,19367653 0,19957707 ! amine biosynthetic process GO:0009309 97 76 0,000 0,19599262 0,20187327 ! tRNA metabolic process GO:0006399 95 76 0,000 0,19599262 0,20178291 ! response to unfolded protein GO:0006986 99 76 0,000 0,19599262 0,20169263 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,19830219 0,2039781 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,19830219 0,20388691 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,19830219 0,20379581 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,19830219 0,20370479 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,20060525 0,20597861 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,20060525 0,20588669 ! cellular respiration GO:0045333 107 79 0,000 0,20290184 0,20815086 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,20290184 0,20805806 ! T cell activation GO:0042110 134 79 0,000 0,20290184 0,20796534 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,20290184 0,20787271 ! chromatin assembly GO:0031497 102 80 0,000 0,20519195 0,21012533 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,20519195 0,21003182 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,20519195 0,20993839 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,20519195 0,20984504 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,20519195 0,20975178 ! forebrain development GO:0030900 131 80 0,000 0,20519195 0,20965859 ! hemostasis GO:0007599 125 81 0,000 0,20747562 0,21189784 ! mRNA transport GO:0051028 121 81 0,000 0,20747562 0,21180379 ! response to protein stimulus GO:0051789 111 81 0,000 0,20747562 0,21170982 ! regulation of neurological system process GO:0031644 122 81 0,000 0,20747562 0,21161593 ! vitamin metabolic process GO:0006766 103 81 0,000 0,20747562 0,21152213 ! detection of stimulus GO:0051606 108 82 0,000 0,20975286 0,21374904 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,21202369 0,21596744 ! regulation of defense response GO:0031347 117 84 0,000 0,21428812 0,21817736 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,21428812 0,21808083 ! sterol metabolic process GO:0016125 120 84 0,000 0,21428812 0,21798437 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,21654617 0,22018399 ! rRNA metabolic process GO:0016072 107 85 0,000 0,21654617 0,22008669 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,21654617 0,21998948 ! nucleosome organization GO:0034728 114 87 0,000 0,22104321 0,22445889 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,22104321 0,22435983 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,22104321 0,22426087 ! female pregnancy GO:0007565 130 87 0,000 0,22104321 0,22416199 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,22328224 0,22633281 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,22328224 0,2262331 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,22328224 0,22613348 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,22328224 0,22603395 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,22551495 0,22819375 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,22551495 0,2280934 ! leukocyte differentiation GO:0002521 143 90 0,000 0,22774138 0,23024403 ! hormone metabolic process GO:0042445 121 90 0,000 0,22774138 0,23014287 ! RNA localization GO:0006403 135 91 0,000 0,22996153 0,23228438 ! ATP metabolic process GO:0046034 137 91 0,000 0,22996153 0,23218241 ! response to virus GO:0009615 122 91 0,000 0,22996153 0,23208053 ! cell fate commitment GO:0045165 141 92 0,000 0,23217543 0,23421206 ! positive regulation of immune response GO:0050778 121 92 0,000 0,23217543 0,23410938 ! sulfur metabolic process GO:0006790 118 92 0,000 0,23217543 0,23400679 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,2343831 0,23612839 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,2343831 0,23602501 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,2343831 0,23592172 ! electron transport chain GO:0022900 123 94 0,000 0,23658454 0,23803343 ! carboxylic acid transport GO:0046942 147 95 0,000 0,23877977 0,24013707 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,24096882 0,24223264 ! protein maturation GO:0051604 129 96 0,000 0,24096882 0,24212682 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,2431517 0,2442135 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,24749902 0,2484713 ! protein import GO:0017038 156 99 0,000 0,24749902 0,24836289 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,24749902 0,24825458 ! regulation of translation GO:0006417 151 100 0,000 0,2496635 0,2503165 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,2496635 0,25020743 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,2496635 0,25009845 ! divalent metal ion transport GO:0070838 171 100 0,000 0,2496635 0,24998957 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,2496635 0,24988078 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,2496635 0,24977209 ! protein localization in organelle GO:0033365 161 100 0,000 0,2496635 0,2496635