pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6481-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! phospholipid dephosphorylation GO:0046839 12 5 3,000 8,639E-11 2,11E-07 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 4,000 2,068E-10 2,527E-07 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 2,587E-10 2,107E-07 ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 6,028E-10 3,682E-07 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 1,204E-09 5,881E-07 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 2,208E-09 8,992E-07 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 3,6E-09 1,256E-06 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 3,000 5,648E-09 1,725E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of protein stability GO:0031647 77 38 4,000 1,622E-08 4,402E-06 ! copper ion transport GO:0006825 22 15 3,000 2,321E-08 5,671E-06 ! response to nutrient GO:0007584 135 84 5,000 2,367E-08 5,256E-06 ! endothelial cell migration GO:0043542 31 17 3,000 4,035E-08 8,214E-06 ! cardiac muscle tissue development GO:0048738 34 17 3,000 4,035E-08 7,582E-06 ! inositol metabolic process GO:0006020 33 19 3,000 6,55E-08 1,143E-05 ! aging GO:0007568 112 58 4,000 1,433E-07 2,334E-05 ! regulation of cell-matrix adhesion GO:0001952 81 23 3,000 1,487E-07 2,271E-05 GO:0010810|regulation of cell-substrate adhesion, ! lipid modification GO:0030258 112 60 4,000 1,703E-07 2,447E-05 ! activation of MAPKKK activity GO:0000185 12 6 2,000 1,725E-07 2,341E-05 ! cellular iron ion homeostasis GO:0006879 57 29 3,000 3,951E-07 5,08E-05 ! negative regulation of protein kinase cascade GO:0010741 72 30 3,000 4,552E-07 5,56E-05 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 4,815E-07 5,601E-05 ! iron ion homeostasis GO:0055072 60 31 3,000 5,218E-07 5,794E-05 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 5,994E-07 6,366E-05 ! negative regulation of cell adhesion GO:0007162 94 37 3,000 1,085E-06 1,104E-04 ! regulation of cell adhesion GO:0030155 241 92 4,000 1,456E-06 1,423E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 2,417E-06 2,271E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 2,417E-06 2,187E-04 ! polyol metabolic process GO:0019751 77 45 3,000 2,417E-06 2,109E-04 ! negative regulation of cell migration GO:0030336 122 46 3,000 2,643E-06 2,226E-04 ! response to UV GO:0009411 120 55 3,000 5,446E-06 4,435E-04 ! negative regulation of cell motion GO:0051271 142 55 3,000 5,446E-06 4,292E-04 ! activation of MAPKK activity GO:0000186 43 17 2,000 5,768E-06 4,403E-04 ! positive regulation of cell migration GO:0030335 137 58 3,000 6,743E-06 4,992E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 6,911E-06 4,966E-04 ! cellular response to hydrogen peroxide GO:0070301 25 19 2,000 8,195E-06 5,72E-04 GO:0042744|hydrogen peroxide catabolic process, ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 1E-05 6,788E-04 ! positive regulation of cell motion GO:0051272 157 65 3,000 1,064E-05 7,027E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 1,121E-05 7,209E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 1,35E-05 8,459E-04 ! negative regulation of kinase activity GO:0033673 145 70 3,000 1,43E-05 8,734E-04 ! cellular response to reactive oxygen species GO:0034614 35 23 2,000 1,489E-05 8,871E-04 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 1,699E-05 9,882E-04 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 1,699E-05 9,652E-04 ! negative regulation of transferase activity GO:0051348 155 74 3,000 1,783E-05 9,901E-04 ! transition metal ion transport GO:0000041 143 75 3,000 1,881E-05 1,021E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 1,928E-05 1,024E-03 ! regulation of catabolic process GO:0009894 173 77 3,000 2,087E-05 1,085E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 2,176E-05 1,107E-03 ! hydrogen peroxide metabolic process GO:0042743 35 26 2,000 2,176E-05 1,085E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 2,444E-05 1,194E-03 ! cellular response to oxidative stress GO:0034599 43 27 2,000 2,444E-05 1,171E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 2,733E-05 1,284E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 4,114E-05 1,896E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 4,259E-05 1,927E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 4,259E-05 1,892E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 4,259E-05 1,858E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 4,259E-05 1,825E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 4,259E-05 1,794E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 4,259E-05 1,763E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 4,259E-05 1,734E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 4,392E-05 1,759E-03 ! negative regulation of protein transport GO:0051224 74 33 2,000 4,518E-05 1,78E-03 ! response to hydrogen peroxide GO:0042542 56 34 2,000 4,948E-05 1,919E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 5,391E-05 2,058E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 6,379E-05 2,398E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 6,379E-05 2,361E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! response to UV-C GO:0010225 14 6 1,000 6,379E-05 2,326E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 6,934E-05 2,491E-03 ! mammary gland development GO:0030879 93 40 2,000 8,097E-05 2,867E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 8,919E-05 3,113E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 8,919E-05 3,069E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 8,919E-05 3,026E-03 ! mRNA stabilization GO:0048255 18 7 1,000 8,919E-05 2,985E-03 GO:0043489|RNA stabilization, ! male sex determination GO:0030238 15 7 1,000 8,919E-05 2,944E-03 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 8,919E-05 2,905E-03 ! centrosome duplication GO:0051298 14 7 1,000 8,919E-05 2,867E-03 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 9,38E-05 2,976E-03 ! response to reactive oxygen species GO:0000302 75 44 2,000 1,079E-04 3,379E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,188E-04 3,673E-03 ! male meiosis GO:0007140 9 8 1,000 1,188E-04 3,627E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,188E-04 3,582E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,188E-04 3,538E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,188E-04 3,496E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 1,188E-04 3,454E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 1,188E-04 3,413E-03 ! blastocyst growth GO:0001832 19 8 1,000 1,188E-04 3,374E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 1,188E-04 3,335E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 1,233E-04 3,423E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,233E-04 3,384E-03 ! response to insulin stimulus GO:0032868 98 47 2,000 1,315E-04 3,57E-03 ! positive regulation of cell cycle GO:0045787 96 48 2,000 1,401E-04 3,76E-03 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 1,49E-04 3,956E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,525E-04 4,006E-03 ! induction of positive chemotaxis GO:0050930 17 9 1,000 1,525E-04 3,963E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 1,525E-04 3,921E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,525E-04 3,88E-03 ! receptor clustering GO:0043113 20 9 1,000 1,525E-04 3,84E-03 ! S phase GO:0051320 10 9 1,000 1,525E-04 3,801E-03 GO:0000084|S phase of mitotic cell cycle, ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 1,883E-04 4,646E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of developmental growth GO:0048638 16 10 1,000 1,904E-04 4,65E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 1,904E-04 4,604E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,904E-04 4,559E-03 ! lung alveolus development GO:0048286 26 10 1,000 1,904E-04 4,515E-03 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 1,904E-04 4,471E-03 ! multicellular organism growth GO:0035264 19 10 1,000 1,904E-04 4,429E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 1,904E-04 4,387E-03 ! motor axon guidance GO:0008045 22 10 1,000 1,904E-04 4,346E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 1,904E-04 4,306E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 1,904E-04 4,266E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,904E-04 4,228E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 1,904E-04 4,189E-03 ! regulation of protein catabolic process GO:0042176 126 56 2,000 2,218E-04 4,838E-03 ! regulation of DNA replication GO:0006275 105 56 2,000 2,218E-04 4,795E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,323E-04 4,979E-03 ! blood vessel remodeling GO:0001974 30 11 1,000 2,323E-04 4,936E-03 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 2,323E-04 4,893E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,323E-04 4,851E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 2,323E-04 4,81E-03 ! oocyte development GO:0048599 20 11 1,000 2,323E-04 4,77E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 2,323E-04 4,73E-03 ! regulation of intracellular transport GO:0032386 108 57 2,000 2,338E-04 4,72E-03 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 2,784E-04 5,575E-03 ! virus-host interaction GO:0019048 30 12 1,000 2,784E-04 5,53E-03 ! regulation of B cell proliferation GO:0030888 22 12 1,000 2,784E-04 5,485E-03 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 2,784E-04 5,442E-03 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 2,784E-04 5,398E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 2,784E-04 5,356E-03 ! histone acetylation GO:0016573 27 12 1,000 2,784E-04 5,314E-03 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,784E-04 5,273E-03 ! regulation of leukocyte migration GO:0002685 29 12 1,000 2,784E-04 5,232E-03 ! oocyte differentiation GO:0009994 21 12 1,000 2,784E-04 5,192E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 2,784E-04 5,153E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 2,784E-04 5,114E-03 ! localization within membrane GO:0051668 26 12 1,000 2,784E-04 5,076E-03 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 2,999E-04 5,428E-03 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 3,286E-04 5,903E-03 GO:0000725|recombinational repair, ! cartilage condensation GO:0001502 22 13 1,000 3,286E-04 5,86E-03 ! response to X-ray GO:0010165 28 13 1,000 3,286E-04 5,817E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 3,286E-04 5,775E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,286E-04 5,734E-03 ! regulation of mRNA stability GO:0043488 32 13 1,000 3,286E-04 5,694E-03 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 3,286E-04 5,653E-03 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 3,294E-04 5,628E-03 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 2,000 3,449E-04 5,85E-03 ! regulation of S phase GO:0033261 26 14 1,000 3,829E-04 6,451E-03 ! response to gamma radiation GO:0010332 30 14 1,000 3,829E-04 6,406E-03 ! regulation of RNA stability GO:0043487 33 14 1,000 3,829E-04 6,363E-03 ! lung development GO:0030324 165 69 2,000 4,112E-04 6,787E-03 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 4,412E-04 7,233E-03 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 4,412E-04 7,185E-03 ! regulation of mRNA processing GO:0050684 26 15 1,000 4,412E-04 7,138E-03 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 4,412E-04 7,091E-03 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 4,412E-04 7,044E-03 ! respiratory tube development GO:0030323 171 72 2,000 4,66E-04 7,392E-03 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 5,035E-04 7,936E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 5,035E-04 7,885E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 5,035E-04 7,835E-03 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 5,035E-04 7,785E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 5,035E-04 7,736E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! respiratory system development GO:0060541 175 74 2,000 5,05E-04 7,71E-03 ! regulation of transcription factor activity GO:0051090 137 75 2,000 5,252E-04 7,97E-03 GO:0090046|regulation of transcription regulator activity, ! signal complex assembly GO:0007172 47 17 1,000 5,699E-04 8,594E-03 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 5,699E-04 8,541E-03 ! activation of protein kinase activity GO:0032147 170 80 2,000 6,343E-04 9,449E-03 ! centrosome cycle GO:0007098 26 18 1,000 6,402E-04 9,479E-03 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 6,402E-04 9,422E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 6,402E-04 9,366E-03 ! response to hypoxia GO:0001666 178 81 2,000 6,577E-04 9,564E-03 ! response to oxygen levels GO:0070482 183 83 2,000 7,062E-04 0,01020834 ! neuromuscular junction development GO:0007528 43 19 1,000 7,146E-04 0,01026926 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 7,146E-04 0,0102092 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 7,146E-04 0,01014985 ! negative regulation of transport GO:0051051 164 85 2,000 7,569E-04 0,01068811 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 7,569E-04 0,01062669 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 7,929E-04 0,01106935 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 7,929E-04 0,01100645 ! protein amino acid acetylation GO:0006473 41 20 1,000 7,929E-04 0,01094427 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 7,929E-04 0,01088279 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 7,929E-04 0,01082199 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of T cell activation GO:0050868 41 20 1,000 7,929E-04 0,01076187 ! regulation of protein transport GO:0051223 165 87 2,000 8,098E-04 0,01093037 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 167 89 2,000 8,651E-04 0,01161192 ! lipid phosphorylation GO:0046834 43 21 1,000 8,752E-04 0,01168394 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 8,752E-04 0,01162044 ! ossification GO:0001503 205 91 2,000 9,227E-04 0,01218406 ! gland development GO:0048732 220 91 2,000 9,227E-04 0,01211856 ! bone development GO:0060348 206 92 2,000 9,523E-04 0,01244152 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 9,614E-04 0,01249367 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 9,614E-04 0,01242756 ! cell aging GO:0007569 48 22 1,000 9,614E-04 0,01236216 ! positive regulation of locomotion GO:0040017 44 22 1,000 9,614E-04 0,01229743 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of intracellular transport GO:0032388 42 22 1,000 9,614E-04 0,01223338 ! positive regulation of B cell activation GO:0050871 42 22 1,000 9,614E-04 0,01217 ! protein stabilization GO:0050821 41 22 1,000 9,614E-04 0,01210727 ! positive regulation of DNA replication GO:0045740 44 23 1,000 1,052E-03 0,01317457 ! regulation of chemotaxis GO:0050920 45 23 1,000 1,052E-03 0,01310736 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 1,11E-03 0,01376294 ! regulation of protein localization GO:0032880 188 97 2,000 1,11E-03 0,01369343 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 1,146E-03 0,01406441 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 1,146E-03 0,01399409 ! sex determination GO:0007530 48 24 1,000 1,146E-03 0,01392447 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 1,146E-03 0,01385554 ! oogenesis GO:0048477 44 24 1,000 1,146E-03 0,01378728 ! negative regulation of catabolic process GO:0009895 52 24 1,000 1,146E-03 0,0137197 ! skeletal muscle tissue development GO:0007519 223 100 2,000 1,212E-03 0,01444041 GO:0060538|skeletal muscle organ development, ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 1,244E-03 0,01474805 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 1,244E-03 0,0146768 ! vasculogenesis GO:0001570 49 25 1,000 1,244E-03 0,01460624 ! negative regulation of DNA replication GO:0008156 45 25 1,000 1,244E-03 0,01453636 ! receptor metabolic process GO:0043112 53 25 1,000 1,244E-03 0,01446714 ! regulation of behavior GO:0050795 48 25 1,000 1,244E-03 0,01439857 ! interaction with host GO:0051701 66 25 1,000 1,244E-03 0,01433065 ! protein tetramerization GO:0051262 57 25 1,000 1,244E-03 0,01426337 ! myelination GO:0042552 50 26 1,000 1,345E-03 0,01535908 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 1,345E-03 0,01528765 ! microtubule organizing center organization GO:0031023 42 26 1,000 1,345E-03 0,01521687 GO:0051297|centrosome organization, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 1,345E-03 0,01514675 GO:0045936|negative regulation of phosphate metabolic process, ! blastocyst development GO:0001824 50 26 1,000 1,345E-03 0,01507726 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 1,451E-03 0,01618728 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 1,451E-03 0,0161137 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 1,561E-03 0,01725145 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 1,561E-03 0,01717374 ! protein amino acid acylation GO:0043543 59 28 1,000 1,561E-03 0,01709673 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 1,674E-03 0,01825658 ! response to organic cyclic substance GO:0014070 58 29 1,000 1,674E-03 0,01817544 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 1,674E-03 0,01809502 ! somitogenesis GO:0001756 52 29 1,000 1,674E-03 0,01801531 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 1,791E-03 0,01919161 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 1,791E-03 0,0191078 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 1,000 1,791E-03 0,01902472 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 1,912E-03 0,0202215 ! ensheathment of neurons GO:0007272 64 31 1,000 1,912E-03 0,02013434 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 1,912E-03 0,02004793 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 2,037E-03 0,02126444 ! peripheral nervous system development GO:0007422 68 32 1,000 2,037E-03 0,02117395 ! response to ionizing radiation GO:0010212 74 33 1,000 2,165E-03 0,02241433 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 2,298E-03 0,02368286 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 2,433E-03 0,02497902 ! calcium-mediated signaling GO:0019722 67 35 1,000 2,433E-03 0,02487451 ! negative regulation of DNA binding GO:0043392 67 36 1,000 2,573E-03 0,02619273 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 2,717E-03 0,02753751 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 2,717E-03 0,02742372 ! tissue remodeling GO:0048771 78 37 1,000 2,717E-03 0,02731086 ! maintenance of protein location in cell GO:0032507 89 37 1,000 2,717E-03 0,02719893 ! female gonad development GO:0008585 71 37 1,000 2,717E-03 0,02708792 ! negative regulation of cell activation GO:0050866 69 37 1,000 2,717E-03 0,02697781 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 2,864E-03 0,02832318 ! negative regulation of binding GO:0051100 71 39 1,000 3,014E-03 0,02969384 ! carbohydrate homeostasis GO:0033500 59 39 1,000 3,014E-03 0,02957459 GO:0042593|glucose homeostasis, ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 3,014E-03 0,02945629 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! development of primary female sexual characteristics GO:0046545 80 40 1,000 3,169E-03 0,03084161 GO:0046660|female sex differentiation, ! mismatch repair GO:0006298 58 40 1,000 3,169E-03 0,03071922 ! regulation of action potential in neuron GO:0019228 80 40 1,000 3,169E-03 0,0305978 ! maintenance of protein location GO:0045185 95 41 1,000 3,327E-03 0,03199726 ! regulation of T cell differentiation GO:0045580 78 42 1,000 3,488E-03 0,03342043 ! cytokinesis GO:0000910 84 42 1,000 3,488E-03 0,03328988 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 3,654E-03 0,03473124 GO:0090047|positive regulation of transcription regulator activity, ! regulation of T cell proliferation GO:0042129 80 43 1,000 3,654E-03 0,03459662 ! segmentation GO:0035282 78 43 1,000 3,654E-03 0,03446305 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 3,823E-03 0,03591701 ! double-strand break repair GO:0006302 85 44 1,000 3,823E-03 0,03577939 ! female gamete generation GO:0007292 71 45 1,000 3,995E-03 0,03725058 ! developmental growth GO:0048589 88 45 1,000 3,995E-03 0,03710894 ! maintenance of location in cell GO:0051651 101 45 1,000 3,995E-03 0,03696838 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 4,171E-03 0,03845125 ! positive regulation of protein transport GO:0051222 80 46 1,000 4,171E-03 0,0383067 ! endosome transport GO:0016197 127 48 1,000 4,534E-03 0,04148086 ! positive regulation of DNA binding GO:0043388 83 48 1,000 4,534E-03 0,04132608 ! vascular process in circulatory system GO:0003018 85 48 1,000 4,534E-03 0,04117245 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 4,72E-03 0,04270814 ! regulation of action potential GO:0001508 102 50 1,000 4,91E-03 0,04426404 ! negative regulation of immune system process GO:0002683 101 51 1,000 5,104E-03 0,04583981 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 5,301E-03 0,0474351 ! histone modification GO:0016570 104 52 1,000 5,301E-03 0,04726198 ! positive regulation of binding GO:0051099 88 52 1,000 5,301E-03 0,04709012 ! response to estrogen stimulus GO:0043627 98 52 1,000 5,301E-03 0,0469195 ! positive regulation of growth GO:0045927 96 53 1,000 5,501E-03 0,04851833 ! chromatin remodeling GO:0006338 122 53 1,000 5,501E-03 0,04834381 ! cartilage development GO:0051216 99 53 1,000 5,501E-03 0,04817053 ! synapse organization GO:0050808 102 53 1,000 5,501E-03 0,04799849 ! regulation of angiogenesis GO:0045765 125 54 1,000 5,705E-03 0,04960064 ! activation of phospholipase C activity GO:0007202 110 54 1,000 5,705E-03 0,04942475 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 5,705E-03 0,04925011 ! regulation of cell shape GO:0008360 142 54 1,000 5,705E-03 0,04907669 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 5,913E-03 0,05068194 ! cell maturation GO:0048469 107 55 1,000 5,913E-03 0,05050473 ! skeletal muscle fiber development GO:0048741 130 56 1,000 6,123E-03 0,05212285 ! regulation of bone remodeling GO:0046850 143 57 1,000 6,337E-03 0,05375856 ! muscle fiber development GO:0048747 131 57 1,000 6,337E-03 0,05357254 ! regulation of phospholipase activity GO:0010517 113 57 1,000 6,337E-03 0,05338781 ! heart morphogenesis GO:0003007 105 57 1,000 6,337E-03 0,05320434 ! nucleotide-excision repair GO:0006289 91 57 1,000 6,337E-03 0,05302214 ! regulation of tissue remodeling GO:0034103 146 58 1,000 6,555E-03 0,05465506 ! positive regulation of lipase activity GO:0060193 115 58 1,000 6,555E-03 0,05446915 ! maintenance of location GO:0051235 124 58 1,000 6,555E-03 0,05428451 ! viral reproductive process GO:0022415 132 62 1,000 7,459E-03 0,06155984 ! regulation of homeostatic process GO:0032844 148 62 1,000 7,459E-03 0,06135257 ! skeletal system morphogenesis GO:0048705 118 63 1,000 7,693E-03 0,06306697 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 7,931E-03 0,06479684 ! gonad development GO:0008406 115 66 1,000 8,415E-03 0,06852952 ! negative regulation of cell growth GO:0030308 142 67 1,000 8,663E-03 0,07030927 ! activation of MAPK activity GO:0000187 124 67 1,000 8,663E-03 0,07007646 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 8,913E-03 0,07186547 ! viral reproduction GO:0016032 142 68 1,000 8,913E-03 0,07162907 ! regulation of lipase activity GO:0060191 137 68 1,000 8,913E-03 0,07139422 ! adaptive immune response GO:0002250 126 68 1,000 8,913E-03 0,0711609 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of cell size GO:0045792 144 69 1,000 9,167E-03 0,07294872 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 9,167E-03 0,07271187 ! developmental maturation GO:0021700 128 69 1,000 9,167E-03 0,07247656 ! germ cell development GO:0007281 133 70 1,000 9,424E-03 0,07426813 ! cAMP-mediated signaling GO:0019933 124 71 1,000 9,684E-03 0,07607327 ! actin filament organization GO:0007015 167 72 1,000 9,948E-03 0,07789176 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01036696 0,08091528 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01036696 0,08065759 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01036696 0,08040153 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01036696 0,0801471 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01036696 0,07989427 ! neuron fate determination GO:0048664 7 5 0,000 0,01036696 0,07964303 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01036696 0,07939336 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01036696 0,07914526 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01036696 0,0788987 ! polyol transport GO:0015791 12 5 0,000 0,01036696 0,07865367 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01036696 0,07841017 ! response to superoxide GO:0000303 10 5 0,000 0,01036696 0,07816816 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01036696 0,07792764 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01036696 0,0776886 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01036696 0,07745102 ! female meiosis GO:0007143 10 5 0,000 0,01036696 0,07721489 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01036696 0,07698019 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01036696 0,07674692 ! hypothalamus development GO:0021854 9 5 0,000 0,01036696 0,07651506 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01036696 0,07628459 ! cobalt ion transport GO:0006824 11 5 0,000 0,01036696 0,07605551 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01036696 0,07582779 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01036696 0,07560144 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01036696 0,07537644 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01036696 0,07515277 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01036696 0,07493042 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01036696 0,07470939 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01036696 0,07448966 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01036696 0,07427121 ! transposition GO:0032196 9 5 0,000 0,01036696 0,07405404 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01036696 0,07383814 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01036696 0,0736235 ! negative chemotaxis GO:0050919 16 5 0,000 0,01036696 0,0734101 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01036696 0,07319793 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01036696 0,07298698 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01036696 0,07277725 ! behavioral response to pain GO:0048266 10 5 0,000 0,01036696 0,07256872 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01036696 0,07236138 ! Notch receptor processing GO:0007220 11 5 0,000 0,01036696 0,07215522 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01036696 0,07195024 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01036696 0,07174641 ! micturition GO:0060073 9 5 0,000 0,01036696 0,07154374 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01036696 0,07134221 ! copulation GO:0007620 9 5 0,000 0,01036696 0,07114181 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01036696 0,07094253 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01036696 0,07074437 ! bioluminescence GO:0008218 9 5 0,000 0,01036696 0,07054731 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01036696 0,07035134 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01036696 0,07015646 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01036696 0,06996266 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01036696 0,06976993 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01036696 0,06957825 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01036696 0,06938763 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01036696 0,06919804 ! grooming behavior GO:0007625 6 5 0,000 0,01036696 0,06900949 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01036696 0,06882197 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01036696 0,06863546 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01036696 0,06844995 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01036696 0,06826545 ! response to protozoan GO:0001562 13 5 0,000 0,01036696 0,06808194 ! lymph vessel development GO:0001945 10 5 0,000 0,01036696 0,06789942 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01036696 0,06771787 ! endochondral ossification GO:0001958 17 5 0,000 0,01036696 0,06753729 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01036696 0,06735767 ! single strand break repair GO:0000012 8 5 0,000 0,01036696 0,067179 ! parathyroid gland development GO:0060017 14 5 0,000 0,01036696 0,06700128 ! anagen GO:0042640 7 5 0,000 0,01036696 0,06682449 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01036696 0,06664864 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01036696 0,06647371 ! cytokine secretion GO:0050663 15 5 0,000 0,01036696 0,06629969 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01036696 0,06612659 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01036696 0,06595438 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01036696 0,06578307 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01036696 0,06561265 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01036696 0,06544311 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01036696 0,06527444 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01036696 0,06510664 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01036696 0,0649397 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01036696 0,06477361 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01036696 0,06460838 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01036696 0,06444398 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01036696 0,06428041 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01036696 0,06411768 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01036696 0,06395577 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01036696 0,06379467 ! microvillus organization GO:0032528 8 5 0,000 0,01036696 0,06363438 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01036696 0,0634749 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01036696 0,06331621 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01036696 0,06315831 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01036696 0,0630012 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01036696 0,06284487 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01036696 0,06268932 ! polyol catabolic process GO:0046174 9 5 0,000 0,01036696 0,06253453 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01036696 0,0623805 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01036696 0,06222723 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01036696 0,06207471 ! muscle cell migration GO:0014812 8 5 0,000 0,01036696 0,06192294 ! mitochondrial fission GO:0000266 8 5 0,000 0,01036696 0,06177191 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01036696 0,06162161 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01036696 0,06147205 ! mRNA transcription GO:0009299 10 5 0,000 0,01036696 0,0613232 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01036696 0,06117508 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01036696 0,06102767 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01036696 0,06088097 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01036696 0,06073497 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01036696 0,06058967 ! monocyte activation GO:0042117 10 5 0,000 0,01036696 0,06044507 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01036696 0,06030115 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01036696 0,06015792 ! response to food GO:0032094 6 5 0,000 0,01036696 0,06001536 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01036696 0,05987348 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01036696 0,05973227 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01036696 0,05959173 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01036696 0,05945184 ! forebrain neuron development GO:0021884 13 5 0,000 0,01036696 0,05931261 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01036696 0,05917403 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01036696 0,05903609 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01036696 0,0588988 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01036696 0,05876214 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01036696 0,05862612 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01036696 0,05849072 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01036696 0,05835595 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01036696 0,0582218 ! lipid glycosylation GO:0030259 7 5 0,000 0,01036696 0,05808826 ! nucleobase transport GO:0015851 6 5 0,000 0,01036696 0,05795534 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01036696 0,05782302 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01036696 0,05769131 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01036696 0,05756019 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01036696 0,05742967 ! basic amino acid transport GO:0015802 12 5 0,000 0,01036696 0,05729974 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01036696 0,05717039 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01036696 0,05704163 ! actin nucleation GO:0045010 11 5 0,000 0,01036696 0,05691345 ! depurination GO:0045007 5 5 0,000 0,01036696 0,05678584 ! depyrimidination GO:0045008 10 5 0,000 0,01036696 0,0566588 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01036696 0,05653233 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01036696 0,05640642 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01036696 0,05628107 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01036696 0,05615628 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01036696 0,05603204 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01036696 0,05590835 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01036696 0,05578521 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01036696 0,0556626 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01036696 0,05554053 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01036696 0,055419 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01036696 0,055298 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01036696 0,05517752 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01036696 0,05505757 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01036696 0,05493814 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01036696 0,05481923 ! response to arsenic GO:0046685 11 5 0,000 0,01036696 0,05470083 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01036696 0,05458294 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01036696 0,05446556 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01036696 0,05434868 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01036696 0,0542323 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01036696 0,05411642 ! response to mercury ion GO:0046689 8 5 0,000 0,01036696 0,05400103 ! response to cadmium ion GO:0046686 7 5 0,000 0,01036696 0,05388613 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01036696 0,05377173 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01036696 0,0536578 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01036696 0,05354436 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01036696 0,0534314 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01036696 0,05331891 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01036696 0,0532069 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01036696 0,05309535 ! decidualization GO:0046697 11 5 0,000 0,01036696 0,05298427 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01036696 0,05287366 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01036696 0,05276351 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01036696 0,05265381 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01036696 0,05254457 ! embryonic cleavage GO:0040016 6 5 0,000 0,01036696 0,05243578 ! peroxisome fission GO:0016559 5 5 0,000 0,01036696 0,05232744 ! histone demethylation GO:0016577 13 5 0,000 0,01036696 0,05221955 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01036696 0,05211211 ! mitotic recombination GO:0006312 9 5 0,000 0,01036696 0,0520051 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01036696 0,05189853 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01036696 0,0517924 ! metaphase plate congression GO:0051310 7 5 0,000 0,01036696 0,0516867 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01036696 0,05158143 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01036696 0,05147659 ! enteric nervous system development GO:0048484 8 5 0,000 0,01036696 0,05137218 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01036696 0,05126818 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01036696 0,05116461 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01036696 0,05106146 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01036696 0,05095872 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01036696 0,05085639 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01036696 0,05075448 ! B cell homeostasis GO:0001782 13 5 0,000 0,01036696 0,05065297 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01036696 0,05055186 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01036696 0,05045116 ! metaphase GO:0051323 11 5 0,000 0,01036696 0,05035086 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01036696 0,05025096 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01036696 0,05015145 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01036696 0,05005234 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01036696 0,04995362 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01036696 0,04985528 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01036696 0,04975733 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01036696 0,04965977 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01036696 0,04956259 ! response to redox state GO:0051775 6 5 0,000 0,01036696 0,04946579 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01036696 0,04936936 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01036696 0,04927331 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01036696 0,04917764 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01036696 0,04908233 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01036696 0,0489874 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01036696 0,04889282 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01036696 0,04879862 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01036696 0,04870478 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01036696 0,04861129 ! striatum development GO:0021756 14 5 0,000 0,01036696 0,04851817 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01036696 0,0484254 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01036696 0,04833298 ! glial cell migration GO:0008347 10 5 0,000 0,01036696 0,04824092 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01036696 0,04814921 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01036696 0,04805784 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01036696 0,04796682 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01036696 0,04787615 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01036696 0,04778582 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01036696 0,04769583 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01036696 0,04760617 ! neuroprotection GO:0043526 8 5 0,000 0,01036696 0,04751685 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01036696 0,04742787 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01036696 0,04733922 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01036696 0,0472509 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01036696 0,04716291 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01036696 0,04707525 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01036696 0,04698791 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01036696 0,0469009 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01036696 0,0468142 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01036696 0,04672783 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01036696 0,04664177 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01036696 0,04655604 ! spindle assembly GO:0051225 6 5 0,000 0,01036696 0,04647061 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01036696 0,0463855 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01036696 0,0463007 ! protein palmitoylation GO:0018345 12 5 0,000 0,01036696 0,04621621 ! drug metabolic process GO:0017144 7 5 0,000 0,01036696 0,04613203 ! stem cell division GO:0017145 11 5 0,000 0,01036696 0,04604815 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01036696 0,04596458 ! organ regeneration GO:0031100 7 5 0,000 0,01036696 0,04588131 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01036696 0,04579834 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01036696 0,04571567 ! reproductive structure development GO:0048608 131 75 1,000 0,01075679 0,04734927 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,01075679 0,04726411 ! axon guidance GO:0007411 162 75 1,000 0,01075679 0,04717926 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,01103276 0,04830293 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,01159402 0,05066939 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,01187928 0,05182336 ! protein oligomerization GO:0051259 149 79 1,000 0,01187928 0,05173099 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,01216761 0,05289231 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01242759 0,05392648 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01242759 0,05383087 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01242759 0,05373559 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01242759 0,05364065 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01242759 0,05354605 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01242759 0,05345178 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01242759 0,05335784 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01242759 0,05326423 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01242759 0,05317095 ! response to oxygen radical GO:0000305 11 6 0,000 0,01242759 0,05307799 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01242759 0,05298536 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01242759 0,05289305 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01242759 0,05280106 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01242759 0,05270939 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01242759 0,05261804 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01242759 0,05252701 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01242759 0,05243629 ! forebrain regionalization GO:0021871 9 6 0,000 0,01242759 0,05234588 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01242759 0,05225578 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01242759 0,052166 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01242759 0,05207652 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01242759 0,05198735 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01242759 0,05189848 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01242759 0,05180992 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01242759 0,05172165 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01242759 0,05163369 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01242759 0,05154603 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01242759 0,05145866 ! malate metabolic process GO:0006108 13 6 0,000 0,01242759 0,05137159 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01242759 0,05128481 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01242759 0,05119833 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01242759 0,05111214 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01242759 0,05102624 ! protein refolding GO:0042026 15 6 0,000 0,01242759 0,05094062 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01242759 0,05085529 ! opsonization GO:0008228 8 6 0,000 0,01242759 0,05077025 ! mating behavior GO:0007617 7 6 0,000 0,01242759 0,05068549 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01242759 0,05060102 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01242759 0,05051682 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01242759 0,05043291 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01242759 0,05034927 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01242759 0,05026591 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01242759 0,05018283 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01242759 0,05010002 ! toxin metabolic process GO:0009404 11 6 0,000 0,01242759 0,05001748 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01242759 0,04993521 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01242759 0,04985322 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01242759 0,04977149 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01242759 0,04969003 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01242759 0,04960884 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01242759 0,04952791 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01242759 0,04944725 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01242759 0,04936685 ! thymic T cell selection GO:0045061 16 6 0,000 0,01242759 0,04928671 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01242759 0,04920682 ! protein lipoylation GO:0009249 10 6 0,000 0,01242759 0,0491272 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01242759 0,04904784 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01242759 0,04896873 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01242759 0,04888987 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01242759 0,04881127 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01242759 0,04873292 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01242759 0,04865482 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01242759 0,04857698 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01242759 0,04849938 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01242759 0,04842203 ! hyperosmotic response GO:0006972 10 6 0,000 0,01242759 0,04834492 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01242759 0,04826806 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01242759 0,04819144 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01242759 0,04811507 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01242759 0,04803894 ! urea metabolic process GO:0019627 7 6 0,000 0,01242759 0,04796305 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01242759 0,0478874 ! neutrophil activation GO:0042119 7 6 0,000 0,01242759 0,04781198 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01242759 0,04773681 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01242759 0,04766187 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01242759 0,04758716 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01242759 0,04751269 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01242759 0,04743845 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01242759 0,04736445 ! neuron apoptosis GO:0051402 15 6 0,000 0,01242759 0,04729067 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01242759 0,04721712 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01242759 0,0471438 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01242759 0,04707071 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01242759 0,04699785 ! carnitine transport GO:0015879 10 6 0,000 0,01242759 0,04692521 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01242759 0,04685279 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01242759 0,0467806 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01242759 0,04670863 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01242759 0,04663688 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01242759 0,04656535 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01242759 0,04649404 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01242759 0,04642295 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01242759 0,04635208 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01242759 0,04628142 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01242759 0,04621097 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01242759 0,04614075 ! astrocyte development GO:0014002 16 6 0,000 0,01242759 0,04607073 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01242759 0,04600092 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01242759 0,04593133 ! interaction with symbiont GO:0051702 14 6 0,000 0,01242759 0,04586195 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01242759 0,04579278 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01242759 0,04572381 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01242759 0,04565505 ! response to copper ion GO:0046688 10 6 0,000 0,01242759 0,0455865 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01242759 0,04551816 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01242759 0,04545002 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01242759 0,04538208 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01242759 0,04531434 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01242759 0,04524681 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01242759 0,04517948 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01242759 0,04511235 ! hair follicle maturation GO:0048820 8 6 0,000 0,01242759 0,04504542 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01242759 0,04497868 ! Schwann cell development GO:0014044 15 6 0,000 0,01242759 0,04491215 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01242759 0,04484581 ! response to pheromone GO:0019236 6 6 0,000 0,01242759 0,04477966 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01242759 0,04471371 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01242759 0,04464796 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01242759 0,04458239 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01242759 0,04451702 ! subpallium development GO:0021544 15 6 0,000 0,01242759 0,04445185 ! neural tube patterning GO:0021532 8 6 0,000 0,01242759 0,04438686 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01242759 0,04432206 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01242759 0,04425745 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01242759 0,04419303 ! G2 phase GO:0051319 16 6 0,000 0,01242759 0,04412879 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01242759 0,04406475 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01242759 0,04400088 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01242759 0,04393721 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01242759 0,04387371 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01242759 0,0438104 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01242759 0,04374728 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01242759 0,04368433 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01242759 0,04362157 ! receptor internalization GO:0031623 11 6 0,000 0,01242759 0,04355898 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01242759 0,04349658 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01242759 0,04343435 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01242759 0,0433723 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01242759 0,04331043 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01242759 0,04324873 ! protein deubiquitination GO:0016579 16 6 0,000 0,01242759 0,04318721 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01242759 0,04312587 ! protein destabilization GO:0031648 9 6 0,000 0,01242759 0,0430647 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01242759 0,0430037 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01242759 0,04294287 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01242759 0,04288222 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01242759 0,04282174 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01242759 0,04276142 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01242759 0,04270128 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01242759 0,04264131 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01242759 0,0425815 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01242759 0,04252186 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01242759 0,04246239 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01242759 0,04240309 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01242759 0,04234395 ! neural plate development GO:0001840 9 6 0,000 0,01242759 0,04228497 ! catecholamine transport GO:0051937 9 6 0,000 0,01242759 0,04222616 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01242759 0,04216751 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01242759 0,04210903 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01242759 0,04205071 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01242759 0,04199255 ! maternal placenta development GO:0001893 12 6 0,000 0,01242759 0,04193454 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01242759 0,0418767 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01242759 0,04181902 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01242759 0,0417615 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01242759 0,04170414 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01242759 0,04164693 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01242759 0,04158988 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01242759 0,04153298 GO:0055081|anion homeostasis, ! meiosis GO:0007126 143 81 1,000 0,012459 0,04158107 GO:0051327|M phase of meiotic cell cycle, ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,012459 0,04152435 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,01275344 0,04244775 ! meiotic cell cycle GO:0051321 144 82 1,000 0,01275344 0,04238999 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,0130509 0,04331977 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,0130509 0,04326099 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of growth GO:0045926 168 85 1,000 0,01365486 0,04520166 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,01365486 0,04514049 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,01396133 0,04609126 ! regulation of lyase activity GO:0051339 169 86 1,000 0,01396133 0,04602906 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,01396133 0,04596703 GO:0002696|positive regulation of leukocyte activation, ! tRNA transcription GO:0009304 17 7 0,000 0,01448399 0,04762368 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01448399 0,04755967 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01448399 0,04749583 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01448399 0,04743217 ! regulation of helicase activity GO:0051095 16 7 0,000 0,01448399 0,04736867 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01448399 0,04730534 ! sleep GO:0030431 16 7 0,000 0,01448399 0,04724218 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01448399 0,0471792 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01448399 0,04711637 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01448399 0,04705372 ! prostate gland development GO:0030850 14 7 0,000 0,01448399 0,04699123 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01448399 0,04692891 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01448399 0,04686675 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01448399 0,04680476 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01448399 0,04674293 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01448399 0,04668126 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01448399 0,04661976 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01448399 0,04655842 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01448399 0,04649724 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01448399 0,04643622 ! glycolipid transport GO:0046836 11 7 0,000 0,01448399 0,04637536 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01448399 0,04631466 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,01448399 0,04625411 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,01448399 0,04619373 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01448399 0,0461335 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01448399 0,04607343 ! pericardium development GO:0060039 16 7 0,000 0,01448399 0,04601352 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01448399 0,04595376 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01448399 0,04589416 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01448399 0,04583471 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01448399 0,04577542 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01448399 0,04571627 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01448399 0,04565729 ! lipoprotein transport GO:0042953 14 7 0,000 0,01448399 0,04559845 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01448399 0,04553976 ! rhythmic behavior GO:0007622 17 7 0,000 0,01448399 0,04548123 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01448399 0,04542285 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01448399 0,04536461 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01448399 0,04530653 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01448399 0,04524859 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01448399 0,0451908 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01448399 0,04513316 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01448399 0,04507566 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01448399 0,04501832 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01448399 0,04496111 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01448399 0,04490406 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01448399 0,04484714 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01448399 0,04479038 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01448399 0,04473375 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01448399 0,04467727 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01448399 0,04462093 ! spinal cord patterning GO:0021511 14 7 0,000 0,01448399 0,04456473 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01448399 0,04450867 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01448399 0,04445276 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01448399 0,04439698 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01448399 0,04434135 ! adrenal gland development GO:0030325 17 7 0,000 0,01448399 0,04428585 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01448399 0,0442305 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01448399 0,04417528 ! ovulation GO:0030728 10 7 0,000 0,01448399 0,0441202 ! adenohypophysis development GO:0021984 11 7 0,000 0,01448399 0,04406525 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01448399 0,04401044 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01448399 0,04395577 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01448399 0,04390124 ! microtubule nucleation GO:0007020 21 7 0,000 0,01448399 0,04384684 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01448399 0,04379257 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01448399 0,04373844 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01448399 0,04368444 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01448399 0,04363058 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01448399 0,04357684 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01448399 0,04352324 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01448399 0,04346977 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01448399 0,04341644 ! galactose metabolic process GO:0006012 13 7 0,000 0,01448399 0,04336323 ! vesicle fusion GO:0006906 20 7 0,000 0,01448399 0,04331015 ! response to dietary excess GO:0002021 8 7 0,000 0,01448399 0,04325721 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01448399 0,04320439 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01448399 0,0431517 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01448399 0,04309914 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01448399 0,04304671 ! organ growth GO:0035265 15 7 0,000 0,01448399 0,04299441 ! nucleoside transport GO:0015858 11 7 0,000 0,01448399 0,04294223 ! nucleoside salvage GO:0043174 11 7 0,000 0,01448399 0,04289018 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01448399 0,04283825 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01448399 0,04278645 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01448399 0,04273478 ! parturition GO:0007567 16 7 0,000 0,01448399 0,04268323 ! rRNA modification GO:0000154 14 7 0,000 0,01448399 0,0426318 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01448399 0,0425805 ! spindle checkpoint GO:0031577 16 7 0,000 0,01448399 0,04252932 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01448399 0,04247827 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01448399 0,04242733 ! monocyte differentiation GO:0030224 16 7 0,000 0,01448399 0,04237652 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01448399 0,04232583 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01448399 0,04227526 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01448399 0,04222482 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,01448399 0,04217449 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01448399 0,04212428 ! fibrinolysis GO:0042730 11 7 0,000 0,01448399 0,04207419 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01448399 0,04202422 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01448399 0,04197437 ! eating behavior GO:0042755 8 7 0,000 0,01448399 0,04192464 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01448399 0,04187503 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01448399 0,04182553 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01448399 0,04177615 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01448399 0,04172688 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01448399 0,04167773 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01448399 0,0416287 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01448399 0,04157978 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01448399 0,04153098 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01448399 0,04148229 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01448399 0,04143372 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01448399 0,04138526 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01448399 0,04133691 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01448399 0,04128868 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01448399 0,04124056 ! histone ubiquitination GO:0016574 9 7 0,000 0,01448399 0,04119255 ! regulation of meiosis GO:0040020 12 7 0,000 0,01448399 0,04114465 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01448399 0,04109686 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01448399 0,04104918 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01448399 0,04100162 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01448399 0,04095416 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01448399 0,04090682 ! transcription termination GO:0006353 14 7 0,000 0,01448399 0,04085958 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01448399 0,04081245 ! anaphase GO:0051322 18 7 0,000 0,01448399 0,04076543 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01448399 0,04071852 ! axonal fasciculation GO:0007413 19 7 0,000 0,01448399 0,04067172 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01448399 0,04062502 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01448399 0,04057844 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01448399 0,04053195 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01448399 0,04048558 ! diuresis GO:0030146 12 7 0,000 0,01448399 0,04043931 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01448399 0,04039315 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01448399 0,04034709 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01448399 0,04030114 ! antibiotic transport GO:0042891 9 7 0,000 0,01448399 0,04025529 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01448399 0,04020954 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01448399 0,0401639 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01448399 0,04011836 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01448399 0,04007293 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01448399 0,0400276 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01448399 0,03998237 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01448399 0,03993724 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01448399 0,03989222 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01448399 0,03984729 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01448399 0,03980247 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01448399 0,03975775 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01448399 0,03971313 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01448399 0,03966861 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01448399 0,03962418 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01448399 0,03957986 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01448399 0,03953564 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01448399 0,03949151 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01448399 0,03944749 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01448399 0,03940356 ! muscle adaptation GO:0043500 13 7 0,000 0,01448399 0,03935973 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01448399 0,039316 ! retina homeostasis GO:0001895 12 7 0,000 0,01448399 0,03927236 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01448399 0,03922882 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01448399 0,03918538 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,01448399 0,03914203 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01448399 0,03909878 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,01489855 0,04017346 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,01521684 0,04098649 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,01553806 0,0418056 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,01618921 0,04350962 ! regulation of membrane potential GO:0042391 179 94 1,000 0,01651912 0,04434748 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,01653617 0,04434453 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,01653617 0,0442959 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,01653617 0,04424739 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,01653617 0,04419897 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,01653617 0,04415067 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,01653617 0,04410247 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,01653617 0,04405438 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,01653617 0,04400639 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,01653617 0,0439585 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,01653617 0,04391072 ! meiotic prophase I GO:0007128 14 8 0,000 0,01653617 0,04386304 ! response to zinc ion GO:0010043 12 8 0,000 0,01653617 0,04381547 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,01653617 0,043768 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,01653617 0,04372063 ! oligopeptide transport GO:0006857 16 8 0,000 0,01653617 0,04367337 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,01653617 0,0436262 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,01653617 0,04357914 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,01653617 0,04353218 ! signal peptide processing GO:0006465 12 8 0,000 0,01653617 0,04348532 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,01653617 0,04343856 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,01653617 0,0433919 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,01653617 0,04334535 ! succinate metabolic process GO:0006105 17 8 0,000 0,01653617 0,04329889 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,01653617 0,04325253 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,01653617 0,04320627 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,01653617 0,04316011 ! estrogen metabolic process GO:0008210 17 8 0,000 0,01653617 0,04311405 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,01653617 0,04306808 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,01653617 0,04302222 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,01653617 0,04297645 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01653617 0,04293078 ! reflex GO:0060004 17 8 0,000 0,01653617 0,0428852 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,01653617 0,04283973 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,01653617 0,04279435 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,01653617 0,04274906 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,01653617 0,04270387 ! pigment granule organization GO:0048753 17 8 0,000 0,01653617 0,04265878 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,01653617 0,04261378 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,01653617 0,04256888 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,01653617 0,04252407 ! astrocyte differentiation GO:0048708 19 8 0,000 0,01653617 0,04247935 ! histidine catabolic process GO:0006548 10 8 0,000 0,01653617 0,04243473 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,01653617 0,0423902 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,01653617 0,04234577 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,01653617 0,04230143 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,01653617 0,04225718 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,01653617 0,04221302 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,01653617 0,04216896 ! melanin metabolic process GO:0006582 17 8 0,000 0,01653617 0,04212499 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,01653617 0,04208111 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,01653617 0,04203732 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,01653617 0,04199362 ! macrophage activation GO:0042116 13 8 0,000 0,01653617 0,04195001 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,01653617 0,0419065 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,01653617 0,04186307 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,01653617 0,04181973 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,01653617 0,04177649 ! purine salvage GO:0043101 12 8 0,000 0,01653617 0,04173333 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,01653617 0,04169026 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,01653617 0,04164728 ! osteoblast development GO:0002076 17 8 0,000 0,01653617 0,04160439 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,01653617 0,04156159 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,01653617 0,04151887 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,01653617 0,04147625 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,01653617 0,04143371 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,01653617 0,04139125 ! response to UV-B GO:0010224 17 8 0,000 0,01653617 0,04134889 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,01653617 0,04130661 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,01653617 0,04126442 ! intermediate filament organization GO:0045109 12 8 0,000 0,01653617 0,04122231 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,01653617 0,04118029 ! cellular extravasation GO:0045123 13 8 0,000 0,01653617 0,04113835 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,01653617 0,0410965 ! response to antibiotic GO:0046677 11 8 0,000 0,01653617 0,04105474 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,01653617 0,04101306 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,01653617 0,04097146 ! DNA topological change GO:0006265 12 8 0,000 0,01653617 0,04092995 ! response to tropane GO:0014073 15 8 0,000 0,01653617 0,04088853 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,01653617 0,04084718 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,01653617 0,04080592 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,01653617 0,04076475 ! mast cell activation GO:0045576 14 8 0,000 0,01653617 0,04072365 ! multicellular organismal aging GO:0010259 20 8 0,000 0,01653617 0,04068264 ! gas homeostasis GO:0033483 14 8 0,000 0,01653617 0,04064171 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,01653617 0,04060087 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,01653617 0,0405601 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,01653617 0,04051942 ! nucleosome disassembly GO:0006337 14 8 0,000 0,01653617 0,04047882 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,01653617 0,0404383 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,01653617 0,04039786 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,01653617 0,04035751 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,01653617 0,04031723 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,01653617 0,04027703 ! intracellular lipid transport GO:0032365 16 8 0,000 0,01653617 0,04023692 ! response to tumor cell GO:0002347 16 8 0,000 0,01653617 0,04019688 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,01653617 0,04015692 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,01653617 0,04011704 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,01653617 0,04007724 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,01653617 0,04003753 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,01653617 0,03999788 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,01653617 0,03995832 ! hormone catabolic process GO:0042447 17 8 0,000 0,01653617 0,03991884 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,01653617 0,03987943 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,01653617 0,0398401 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,01653617 0,03980085 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,01653617 0,03976168 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,01653617 0,03972258 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,01653617 0,03968356 ! adult feeding behavior GO:0008343 10 8 0,000 0,01653617 0,03964462 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,01653617 0,03960575 ! ATP catabolic process GO:0006200 11 8 0,000 0,01653617 0,03956696 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,01653617 0,03952824 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,01653617 0,0394896 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,01653617 0,03945104 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,01653617 0,03941255 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,01653617 0,03937414 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,01653617 0,0393358 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,01653617 0,03929753 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,01653617 0,03925934 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,01653617 0,03922123 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,01653617 0,03918318 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,01653617 0,03914522 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,01653617 0,03910732 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,01653617 0,0390695 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,01653617 0,03903175 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,01653617 0,03899408 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,01653617 0,03895647 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,01653617 0,03891894 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,01653617 0,03888149 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,01653617 0,0388441 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,0168519 0,03954772 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,0168519 0,03950977 ! sex differentiation GO:0007548 171 96 1,000 0,01718753 0,04025804 ! regulation of T cell activation GO:0050863 175 96 1,000 0,01718753 0,04021948 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,01786732 0,04177019 ! axon extension GO:0048675 16 9 0,000 0,01858413 0,04340443 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,01858413 0,04336297 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,01858413 0,04332159 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,01858413 0,0432803 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,01858413 0,04323908 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,01858413 0,04319794 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,01858413 0,04315687 ! reproductive behavior GO:0019098 22 9 0,000 0,01858413 0,04311589 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,01858413 0,04307498 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,01858413 0,04303415 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,01858413 0,0429934 ! UTP metabolic process GO:0046051 10 9 0,000 0,01858413 0,04295273 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,01858413 0,04291213 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,01858413 0,04287161 ! artery development GO:0060840 25 9 0,000 0,01858413 0,04283116 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,01858413 0,04279079 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,01858413 0,0427505 ! equilibrioception GO:0050957 20 9 0,000 0,01858413 0,04271028 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,01858413 0,04267014 ! chemosensory behavior GO:0007635 21 9 0,000 0,01858413 0,04263008 ! microtubule bundle formation GO:0001578 22 9 0,000 0,01858413 0,04259008 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,01858413 0,04255017 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,01858413 0,04251033 ! leukocyte degranulation GO:0043299 16 9 0,000 0,01858413 0,04247056 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,01858413 0,04243087 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,01858413 0,04239125 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,01858413 0,04235171 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,01858413 0,04231224 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,01858413 0,04227284 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,01858413 0,04223352 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,01858413 0,04219427 ! protein targeting to ER GO:0045047 25 9 0,000 0,01858413 0,04215509 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,01858413 0,04211598 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,01858413 0,04207695 ! T cell selection GO:0045058 27 9 0,000 0,01858413 0,04203799 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,01858413 0,0419991 ! glycine catabolic process GO:0006546 15 9 0,000 0,01858413 0,04196029 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,01858413 0,04192154 ! endosome organization GO:0007032 20 9 0,000 0,01858413 0,04188287 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,01858413 0,04184427 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,01858413 0,04180574 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,01858413 0,04176728 ! mannose metabolic process GO:0006013 13 9 0,000 0,01858413 0,04172889 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,01858413 0,04169057 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,01858413 0,04165232 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,01858413 0,04161414 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,01858413 0,04157604 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,01858413 0,041538 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,01858413 0,04150003 ! retinol metabolic process GO:0042572 20 9 0,000 0,01858413 0,04146213 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,01858413 0,0414243 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,01858413 0,04138654 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,01858413 0,04134884 ! macrophage differentiation GO:0030225 15 9 0,000 0,01858413 0,04131122 ! oligodendrocyte development GO:0014003 11 9 0,000 0,01858413 0,04127366 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,01858413 0,04123618 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,01858413 0,04119876 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,01858413 0,04116141 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,01858413 0,04112412 ! response to amine stimulus GO:0014075 13 9 0,000 0,01858413 0,04108691 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,01858413 0,04104976 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,01858413 0,04101267 ! erythrocyte development GO:0048821 17 9 0,000 0,01858413 0,04097566 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,01858413 0,04093871 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,01858413 0,04090183 ! renal water homeostasis GO:0003091 15 9 0,000 0,01858413 0,04086501 ! postreplication repair GO:0006301 25 9 0,000 0,01858413 0,04082826 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,01858413 0,04079158 ! icosanoid secretion GO:0032309 15 9 0,000 0,01858413 0,04075496 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,01858413 0,04071841 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,01858413 0,04068193 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,01858413 0,04064551 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,01858413 0,04060915 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,01858413 0,04057286 ! sterol catabolic process GO:0016127 14 9 0,000 0,01858413 0,04053663 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,01858413 0,04050047 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,01858413 0,04046438 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,01858413 0,04042834 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,01858413 0,04039238 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,01858413 0,04035647 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,01858413 0,04032063 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,01858413 0,04028485 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,01858413 0,04024914 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,01858413 0,04021349 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,01858413 0,0401779 ! purine base metabolic process GO:0006144 25 9 0,000 0,01858413 0,04014238 ! pigment granule transport GO:0051904 17 9 0,000 0,01858413 0,04010692 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,01858413 0,04007152 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,01858413 0,04003618 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,01858413 0,04000091 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,01858413 0,0399657 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,01858413 0,03993055 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,01858413 0,03989546 ! mitochondrion localization GO:0051646 18 9 0,000 0,01858413 0,03986043 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02062788 0,04420519 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02062788 0,04416645 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02062788 0,04412778 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02062788 0,04408917 ! associative learning GO:0008306 21 10 0,000 0,02062788 0,04405063 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02062788 0,04401216 ! phosphate transport GO:0006817 24 10 0,000 0,02062788 0,04397375 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02062788 0,04393541 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02062788 0,04389714 ! CTP metabolic process GO:0046036 11 10 0,000 0,02062788 0,04385894 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02062788 0,0438208 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02062788 0,04378273 ! GTP metabolic process GO:0046039 11 10 0,000 0,02062788 0,04374472 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02062788 0,04370678 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02062788 0,04366891 ! social behavior GO:0035176 29 10 0,000 0,02062788 0,0436311 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02062788 0,04359336 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02062788 0,04355568 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02062788 0,04351807 ! androgen metabolic process GO:0008209 17 10 0,000 0,02062788 0,04348052 ! phospholipid efflux GO:0033700 19 10 0,000 0,02062788 0,04344303 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02062788 0,04340562 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02062788 0,04336826 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02062788 0,04333097 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02062788 0,04329375 ! pathogenesis GO:0009405 17 10 0,000 0,02062788 0,04325658 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02062788 0,04321949 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02062788 0,04318245 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02062788 0,04314548 ! endoderm development GO:0007492 18 10 0,000 0,02062788 0,04310857 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02062788 0,04307173 ! arginine catabolic process GO:0006527 17 10 0,000 0,02062788 0,04303494 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02062788 0,04299823 ! proline metabolic process GO:0006560 13 10 0,000 0,02062788 0,04296157 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02062788 0,04292497 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02062788 0,04288844 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02062788 0,04285197 ! V(D)J recombination GO:0033151 34 10 0,000 0,02062788 0,04281556 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02062788 0,04277922 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02062788 0,04274293 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02062788 0,04270671 ! B cell proliferation GO:0042100 19 10 0,000 0,02062788 0,04267055 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02062788 0,04263445 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02062788 0,04259841 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02062788 0,04256243 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02062788 0,04252651 ! ruffle organization GO:0031529 17 10 0,000 0,02062788 0,04249066 ! epithelial cell development GO:0002064 21 10 0,000 0,02062788 0,04245486 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02062788 0,04241912 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02062788 0,04238345 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02062788 0,04234783 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02062788 0,04231228 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02062788 0,04227678 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02062788 0,04224134 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,02062788 0,04220596 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02062788 0,04217064 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02062788 0,04213538 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02062788 0,04210018 ! segment specification GO:0007379 15 10 0,000 0,02062788 0,04206504 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02062788 0,04202996 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02062788 0,04199493 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02062788 0,04195997 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02062788 0,04192506 ! response to dsRNA GO:0043331 23 10 0,000 0,02062788 0,04189021 ! DNA ligation GO:0006266 18 10 0,000 0,02062788 0,04185542 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02062788 0,04182068 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02062788 0,041786 ! melanosome localization GO:0032400 16 10 0,000 0,02062788 0,04175138 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02062788 0,04171682 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02062788 0,04168232 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02062788 0,04164787 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02062788 0,04161348 ! induction of an organ GO:0001759 17 10 0,000 0,02062788 0,04157914 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02062788 0,04154486 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02062788 0,04151064 ! protein sumoylation GO:0016925 17 10 0,000 0,02062788 0,04147648 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02062788 0,04144237 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02062788 0,04140832 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02062788 0,04137432 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02062788 0,04134038 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02062788 0,04130649 ! salivary gland development GO:0007431 28 10 0,000 0,02062788 0,04127266 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02062788 0,04123889 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02062788 0,04120517 ! midbrain development GO:0030901 14 10 0,000 0,02062788 0,0411715 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02062788 0,04113789 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02062788 0,04110434 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02062788 0,04107084 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02062788 0,04103739 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02062788 0,041004 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02062788 0,04097067 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02062788 0,04093738 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02062788 0,04090416 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02062788 0,04087098 ! detection of calcium ion GO:0005513 24 10 0,000 0,02062788 0,04083786 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02062788 0,04080479 ! blastocyst formation GO:0001825 18 10 0,000 0,02062788 0,04077178 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02062788 0,04073882 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02062788 0,04070591 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02062788 0,04067306 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02062788 0,04064026 ! response to nicotine GO:0035094 20 10 0,000 0,02062788 0,04060751 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02062788 0,04057481 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,02266744 0,04455073 ! respiratory burst GO:0045730 17 11 0,000 0,02266744 0,04451491 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,02266744 0,04447916 ! neuron fate specification GO:0048665 18 11 0,000 0,02266744 0,04444346 ! telencephalon cell migration GO:0022029 23 11 0,000 0,02266744 0,04440782 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,02266744 0,04437224 ! thyroid gland development GO:0030878 26 11 0,000 0,02266744 0,04433671 ! synapsis GO:0007129 14 11 0,000 0,02266744 0,04430124 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,02266744 0,04426583 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,02266744 0,04423047 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,02266744 0,04419517 ! response to pain GO:0048265 27 11 0,000 0,02266744 0,04415993 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,02266744 0,04412474 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,02266744 0,04408961 ! bone resorption GO:0045453 16 11 0,000 0,02266744 0,04405454 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,02266744 0,04401952 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,02266744 0,04398455 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,02266744 0,04394964 ! melanocyte differentiation GO:0030318 20 11 0,000 0,02266744 0,04391479 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,02266744 0,04387999 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,02266744 0,04384525 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,02266744 0,04381056 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,02266744 0,04377593 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,02266744 0,04374135 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,02266744 0,04370683 ! UV protection GO:0009650 20 11 0,000 0,02266744 0,04367236 ! adult heart development GO:0007512 16 11 0,000 0,02266744 0,04363794 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,02266744 0,04360358 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,02266744 0,04356928 ! macroautophagy GO:0016236 19 11 0,000 0,02266744 0,04353503 ! temperature homeostasis GO:0001659 18 11 0,000 0,02266744 0,04350083 ! behavioral fear response GO:0001662 27 11 0,000 0,02266744 0,04346668 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,02266744 0,04343259 ! negative regulation of ossification GO:0030279 27 11 0,000 0,02266744 0,04339855 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,02266744 0,04336457 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,02266744 0,04333064 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,02266744 0,04329676 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,02266744 0,04326293 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,02266744 0,04322916 ! regulation of organ growth GO:0046620 14 11 0,000 0,02266744 0,04319544 ! pigment granule localization GO:0051875 20 11 0,000 0,02266744 0,04316177 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,02266744 0,04312816 ! vasoconstriction GO:0042310 20 11 0,000 0,02266744 0,04309459 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,02266744 0,04306108 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,02266744 0,04302762 ! embryonic axis specification GO:0000578 19 11 0,000 0,02266744 0,04299422 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,02266744 0,04296086 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,02266744 0,04292756 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,02266744 0,04289431 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,02266744 0,04286111 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,02266744 0,04282796 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,02266744 0,04279486 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,02266744 0,04276182 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,02266744 0,04272882 ! prophase GO:0051324 17 11 0,000 0,02266744 0,04269588 ! neuroblast proliferation GO:0007405 25 11 0,000 0,02266744 0,04266298 ! nucleosome positioning GO:0016584 15 11 0,000 0,02266744 0,04263014 ! regulation of isotype switching GO:0045191 24 11 0,000 0,02266744 0,04259735 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,02266744 0,04256461 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,02266744 0,04253191 ! apical protein localization GO:0045176 18 11 0,000 0,02266744 0,04249927 ! acid secretion GO:0046717 20 11 0,000 0,02266744 0,04246668 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,02266744 0,04243414 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,02266744 0,04240165 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,02266744 0,04236921 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,02266744 0,04233681 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,02266744 0,04230447 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,02266744 0,04227218 ! cholesterol efflux GO:0033344 21 11 0,000 0,02266744 0,04223993 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,02266744 0,04220774 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,02266744 0,04217559 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,02266744 0,04214349 ! embryonic gut development GO:0048566 19 11 0,000 0,02266744 0,04211145 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,02266744 0,04207945 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,02266744 0,0420475 ! activation of innate immune response GO:0002218 16 11 0,000 0,02266744 0,04201559 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,02266744 0,04198374 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,02266744 0,04195193 ! lysogeny GO:0030069 22 11 0,000 0,02266744 0,04192018 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,02266744 0,04188847 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,02266744 0,0418568 ! sequestering of metal ion GO:0051238 15 11 0,000 0,02266744 0,04182519 ! nucleus localization GO:0051647 22 11 0,000 0,02266744 0,04179362 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,0247028 0,04551203 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,0247028 0,04547773 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,0247028 0,04544348 ! mating GO:0007618 17 12 0,000 0,0247028 0,04540929 ! protein complex disassembly GO:0043241 28 12 0,000 0,0247028 0,04537515 GO:0043624|cellular protein complex disassembly, ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,0247028 0,04534106 ! hippocampus development GO:0021766 29 12 0,000 0,0247028 0,04530702 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,0247028 0,04527303 ! T cell proliferation GO:0042098 32 12 0,000 0,0247028 0,04523909 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,0247028 0,0452052 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,0247028 0,04517137 ! ventral spinal cord development GO:0021517 25 12 0,000 0,0247028 0,04513758 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,0247028 0,04510385 ! drug transport GO:0015893 16 12 0,000 0,0247028 0,04507016 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,0247028 0,04503653 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,0247028 0,04500294 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,0247028 0,04496941 ! polyamine metabolic process GO:0006595 18 12 0,000 0,0247028 0,04493593 ! focal adhesion formation GO:0048041 37 12 0,000 0,0247028 0,04490249 ! mitotic spindle organization GO:0007052 23 12 0,000 0,0247028 0,04486911 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,0247028 0,04483577 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,0247028 0,04480249 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,0247028 0,04476925 ! lipid digestion GO:0044241 21 12 0,000 0,0247028 0,04473606 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,0247028 0,04470292 ! entry into host cell GO:0030260 34 12 0,000 0,0247028 0,04466984 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0247028 0,0446368 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,0247028 0,0446038 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,0247028 0,04457086 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,0247028 0,04453797 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,0247028 0,04450512 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,0247028 0,04447233 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,0247028 0,04443958 ! snRNA metabolic process GO:0016073 30 12 0,000 0,0247028 0,04440688 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,0247028 0,04437423 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,0247028 0,04434162 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,0247028 0,04430907 ! cranial nerve development GO:0021545 23 12 0,000 0,0247028 0,04427656 ! fucose catabolic process GO:0019317 25 12 0,000 0,0247028 0,0442441 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,0247028 0,04421168 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,0247028 0,04417932 ! autonomic nervous system development GO:0048483 24 12 0,000 0,0247028 0,044147 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,0247028 0,04411473 ! zymogen activation GO:0031638 18 12 0,000 0,0247028 0,0440825 ! T cell homeostasis GO:0043029 28 12 0,000 0,0247028 0,04405033 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,0247028 0,0440182 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,0247028 0,04398611 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,0247028 0,04395408 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,0247028 0,04392209 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,0247028 0,04389014 ! defense response to fungus GO:0050832 15 12 0,000 0,0247028 0,04385825 ! developmental induction GO:0031128 22 12 0,000 0,0247028 0,0438264 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,0247028 0,04379459 ! lamellipodium assembly GO:0030032 24 12 0,000 0,0247028 0,04376283 ! response to cold GO:0009409 17 12 0,000 0,0247028 0,04373112 ! establishment of cell polarity GO:0030010 21 12 0,000 0,0247028 0,04369946 ! regulation of synapse organization GO:0050807 18 12 0,000 0,0247028 0,04366783 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,02673399 0,04722424 ! cGMP metabolic process GO:0046068 18 13 0,000 0,02673399 0,04719012 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,02673399 0,04715605 ! regulation of chemokine production GO:0032642 18 13 0,000 0,02673399 0,04712203 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,02673399 0,04708805 ! peroxisomal transport GO:0043574 28 13 0,000 0,02673399 0,04705413 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,02673399 0,04702025 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,02673399 0,04698642 ! organelle fusion GO:0048284 36 13 0,000 0,02673399 0,04695264 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,02673399 0,04691891 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,02673399 0,04688523 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,02673399 0,0468516 ! endocrine pancreas development GO:0031018 25 13 0,000 0,02673399 0,04681801 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,02673399 0,04678448 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,02673399 0,04675099 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,02673399 0,04671754 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,02673399 0,04668415 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,02673399 0,04665081 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,02673399 0,04661751 ! methionine metabolic process GO:0006555 31 13 0,000 0,02673399 0,04658426 ! plasma membrane organization GO:0007009 27 13 0,000 0,02673399 0,04655105 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,02673399 0,0465179 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,02673399 0,04648479 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,02673399 0,04645173 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,02673399 0,04641871 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,02673399 0,04638574 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,02673399 0,04635282 ! exocrine system development GO:0035272 34 13 0,000 0,02673399 0,04631995 ! asymmetric protein localization GO:0008105 24 13 0,000 0,02673399 0,04628712 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,02673399 0,04625434 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,02673399 0,0462216 ! L-glutamate transport GO:0015813 30 13 0,000 0,02673399 0,04618892 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,02673399 0,04615627 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,02673399 0,04612368 ! protein homotetramerization GO:0051289 24 13 0,000 0,02673399 0,04609113 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,02673399 0,04605862 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,02673399 0,04602616 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,02673399 0,04599375 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,02673399 0,04596138 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,02673399 0,04592906 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,02673399 0,04589679 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,02673399 0,04586456 ! histone methylation GO:0016571 29 13 0,000 0,02673399 0,04583237 ! chromatin silencing GO:0006342 29 13 0,000 0,02673399 0,04580023 ! gland morphogenesis GO:0022612 31 13 0,000 0,02673399 0,04576813 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,02673399 0,04573608 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,02673399 0,04570408 ! regulation of epidermis development GO:0045682 19 13 0,000 0,02673399 0,04567212 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,02673399 0,0456402 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,02673399 0,04560833 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,02673399 0,0455765 ! spleen development GO:0048536 24 13 0,000 0,02673399 0,04554472 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,02673399 0,04551298 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,02673399 0,04548129 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,02673399 0,04544964 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,02673399 0,04541803 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,02673399 0,04538647 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,02673399 0,04535495 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,02673399 0,04532348 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,02673399 0,04529204 ! insulin secretion GO:0030073 24 13 0,000 0,02673399 0,04526066 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,02673399 0,04522931 ! acrosome reaction GO:0007340 19 13 0,000 0,02673399 0,04519801 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,02673399 0,04516675 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,02673399 0,04513554 ! rRNA transcription GO:0009303 28 14 0,000 0,028761 0,04852425 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,028761 0,04849076 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,028761 0,04845732 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,028761 0,04842392 ! non-recombinational repair GO:0000726 29 14 0,000 0,028761 0,04839057 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,028761 0,04835727 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,028761 0,04832401 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,028761 0,0482908 ! RNA polyadenylation GO:0043631 32 14 0,000 0,028761 0,04825763 ! lipid localization GO:0010876 32 14 0,000 0,028761 0,04822451 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,028761 0,04819144 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,028761 0,0481584 ! regulated secretory pathway GO:0045055 24 14 0,000 0,028761 0,04812542 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,028761 0,04809248 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,028761 0,04805958 ! arginine metabolic process GO:0006525 21 14 0,000 0,028761 0,04802673 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,028761 0,04799393 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,028761 0,04796117 ! regulation of heart rate GO:0002027 25 14 0,000 0,028761 0,04792845 ! fear response GO:0042596 34 14 0,000 0,028761 0,04789578 ! organic alcohol transport GO:0015850 29 14 0,000 0,028761 0,04786316 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,028761 0,04783057 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,028761 0,04779804 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,028761 0,04776554 ! neutral amino acid transport GO:0015804 28 14 0,000 0,028761 0,04773309 ! bone mineralization GO:0030282 18 14 0,000 0,028761 0,04770069 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,028761 0,04766833 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,028761 0,04763601 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,028761 0,04760373 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,028761 0,0475715 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,028761 0,04753932 ! regulation of cellular pH GO:0030641 27 14 0,000 0,028761 0,04750718 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,028761 0,04747508 ! ribosome assembly GO:0042255 18 14 0,000 0,028761 0,04744302 ! cerebellum development GO:0021549 23 14 0,000 0,028761 0,04741101 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,028761 0,04737904 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,028761 0,04734711 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,028761 0,04731523 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,028761 0,04728339 ! NADP metabolic process GO:0006739 24 14 0,000 0,028761 0,04725159 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,028761 0,04721983 ! oxygen transport GO:0015671 22 14 0,000 0,028761 0,04718812 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,028761 0,04715645 ! male genitalia development GO:0030539 26 14 0,000 0,028761 0,04712482 ! regulation of axon extension GO:0030516 43 14 0,000 0,028761 0,04709324 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,028761 0,0470617 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,028761 0,0470302 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,028761 0,04699874 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,03078384 0,05027067 ! lactation GO:0007595 30 15 0,000 0,03078384 0,05023709 ! reproductive cellular process GO:0048610 22 15 0,000 0,03078384 0,05020355 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,03078384 0,05017006 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,03078384 0,05013662 ! superoxide anion generation GO:0042554 22 15 0,000 0,03078384 0,05010321 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,03078384 0,05006986 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,03078384 0,05003654 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,03078384 0,05000327 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,03078384 0,04997005 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,03078384 0,04993687 ! sulfate transport GO:0008272 27 15 0,000 0,03078384 0,04990373 ! response to cAMP GO:0051591 25 15 0,000 0,03078384 0,04987064 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,03078384 0,04983759 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,03078384 0,04980458 ! response to hexose stimulus GO:0009746 25 15 0,000 0,03078384 0,04977162 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,03078384 0,04973871 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,03078384 0,04970583 ! vesicle coating GO:0006901 38 15 0,000 0,03078384 0,049673 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,03078384 0,04964021 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,03078384 0,04960747 ! regulation of exocytosis GO:0017157 26 15 0,000 0,03078384 0,04957477 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,03078384 0,04954211 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,03078384 0,0495095 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,03078384 0,04947692 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,03078384 0,04944439 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,03078384 0,04941191 ! regulation of vasodilation GO:0042312 27 15 0,000 0,03078384 0,04937946 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,03078384 0,04934706 ! histone deacetylation GO:0016575 24 15 0,000 0,03078384 0,0493147 ! water homeostasis GO:0030104 28 15 0,000 0,03078384 0,04928239 ! cofactor transport GO:0051181 30 15 0,000 0,03078384 0,04925011 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,03078384 0,04921788 ! muscle maintenance GO:0046716 26 15 0,000 0,03078384 0,04918569 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,03078384 0,04915354 ! intestinal absorption GO:0050892 31 15 0,000 0,03078384 0,04912144 ! dopamine metabolic process GO:0042417 35 15 0,000 0,03078384 0,04908938 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,03078384 0,04905735 ! heme biosynthetic process GO:0006783 33 15 0,000 0,03078384 0,04902537 ! cell killing GO:0001906 32 15 0,000 0,03078384 0,04899344 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,03078384 0,04896154 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,03078384 0,04892968 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,03078384 0,04889787 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,03078384 0,0488661 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,03078384 0,04883437 ! actin filament polymerization GO:0030041 27 15 0,000 0,03078384 0,04880268 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,03078384 0,04877103 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,03280253 0,05193557 ! positive regulation of cell size GO:0045793 29 16 0,000 0,03280253 0,05190193 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,03280253 0,05186834 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,03280253 0,05183479 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,03280253 0,05180128 ! bone remodeling GO:0046849 28 16 0,000 0,03280253 0,05176782 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,03280253 0,0517344 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,03280253 0,05170102 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,03280253 0,05166769 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,03280253 0,05163439 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,03280253 0,05160115 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,03280253 0,05156794 ! startle response GO:0001964 28 16 0,000 0,03280253 0,05153478 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,03280253 0,05150166 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,03280253 0,05146858 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,03280253 0,05143555 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,03280253 0,05140255 ! protein polyubiquitination GO:0000209 41 16 0,000 0,03280253 0,0513696 ! glutamate metabolic process GO:0006536 25 16 0,000 0,03280253 0,05133669 ! pituitary gland development GO:0021983 30 16 0,000 0,03280253 0,05130383 ! response to osmotic stress GO:0006970 27 16 0,000 0,03280253 0,051271 ! lysosomal transport GO:0007041 31 16 0,000 0,03280253 0,05123822 ! fructose metabolic process GO:0006000 25 16 0,000 0,03280253 0,05120548 ! L-amino acid transport GO:0015807 33 16 0,000 0,03280253 0,05117278 ! stem cell development GO:0048864 46 16 0,000 0,03280253 0,05114013 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,03280253 0,05110751 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,03280253 0,05107494 ! intermediate filament-based process GO:0045103 36 16 0,000 0,03280253 0,05104241 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,03280253 0,05100992 ! negative regulation of immune response GO:0050777 38 16 0,000 0,03280253 0,05097747 ! axon cargo transport GO:0008088 46 16 0,000 0,03280253 0,05094506 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,03280253 0,05091269 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,03280253 0,05088037 ! DNA replication initiation GO:0006270 28 16 0,000 0,03280253 0,05084808 ! neuron recognition GO:0008038 40 16 0,000 0,03280253 0,05081584 ! mRNA splice site selection GO:0006376 44 16 0,000 0,03280253 0,05078364 ! tissue regeneration GO:0042246 27 16 0,000 0,03280253 0,05075148 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,03280253 0,05071935 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,03280253 0,05068727 ! biomineral formation GO:0031214 22 16 0,000 0,03280253 0,05065523 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,03280253 0,05062323 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,03280253 0,05059128 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,03280253 0,05055936 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,03280253 0,05052748 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,03280253 0,05049564 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,03280253 0,05046384 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,03280253 0,05043208 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,03280253 0,05040036 ! peptide hormone processing GO:0016486 27 16 0,000 0,03280253 0,05036869 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,03481707 0,05342846 ! metencephalon development GO:0022037 32 17 0,000 0,03481707 0,05339492 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,03481707 0,05336142 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,03481707 0,05332796 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,03481707 0,05329455 ! filopodium assembly GO:0046847 42 17 0,000 0,03481707 0,05326118 ! gene silencing by RNA GO:0031047 38 17 0,000 0,03481707 0,05322785 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,03481707 0,05319456 ! glial cell development GO:0021782 28 17 0,000 0,03481707 0,05316131 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,03481707 0,05312811 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,03481707 0,05309495 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,03481707 0,05306182 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,03481707 0,05302874 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,03481707 0,0529957 ! myoblast differentiation GO:0045445 50 17 0,000 0,03481707 0,0529627 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,03481707 0,05292975 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,03481707 0,05289683 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,03481707 0,05286395 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,03481707 0,05283112 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,03481707 0,05279833 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,03481707 0,05276557 ! membrane budding GO:0006900 42 17 0,000 0,03481707 0,05273286 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,03481707 0,05270019 ! regulation of protein binding GO:0043393 33 17 0,000 0,03481707 0,05266756 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,03481707 0,05263497 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,03481707 0,05260241 ! genitalia development GO:0048806 32 17 0,000 0,03481707 0,0525699 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,03481707 0,05253743 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,03481707 0,052505 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,03481707 0,05247261 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,03481707 0,05244026 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,03481707 0,05240795 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,03481707 0,05237568 ! steroid catabolic process GO:0006706 34 17 0,000 0,03481707 0,05234345 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,03481707 0,05231126 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,03481707 0,0522791 ! gas transport GO:0015669 26 17 0,000 0,03481707 0,05224699 ! organic cation transport GO:0015695 32 17 0,000 0,03481707 0,05221492 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,03481707 0,05218289 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,03481707 0,05215089 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,03682747 0,05512838 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,03682747 0,05509462 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,03682747 0,0550609 ! limbic system development GO:0021761 40 18 0,000 0,03682747 0,05502723 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,03682747 0,05499359 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,03682747 0,05496 ! adult walking behavior GO:0007628 36 18 0,000 0,03682747 0,05492644 ! patterning of blood vessels GO:0001569 43 18 0,000 0,03682747 0,05489293 ! heart looping GO:0001947 34 18 0,000 0,03682747 0,05485946 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,03682747 0,05482603 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,03682747 0,05479264 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,03682747 0,05475929 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,03682747 0,05472598 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,03682747 0,05469271 ! glycine metabolic process GO:0006544 30 18 0,000 0,03682747 0,05465949 ! glutamine metabolic process GO:0006541 29 18 0,000 0,03682747 0,0546263 ! response to retinoic acid GO:0032526 31 18 0,000 0,03682747 0,05459315 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,03682747 0,05456005 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,03682747 0,05452698 ! DNA integration GO:0015074 32 18 0,000 0,03682747 0,05449395 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,03682747 0,05446097 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,03682747 0,05442802 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,03682747 0,05439511 ! neural crest cell migration GO:0001755 41 18 0,000 0,03682747 0,05436224 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,03682747 0,05432942 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,03682747 0,05429663 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,03682747 0,05426388 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,03682747 0,05423117 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,03682747 0,0541985 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,03682747 0,05416587 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,03682747 0,05413328 ! detection of bacterium GO:0016045 22 18 0,000 0,03682747 0,05410073 ! nerve development GO:0021675 34 18 0,000 0,03682747 0,05406822 ! defense response to virus GO:0051607 43 18 0,000 0,03682747 0,05403574 ! microspike assembly GO:0030035 46 18 0,000 0,03682747 0,05400331 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,03682747 0,05397091 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,03682747 0,05393856 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,03883374 0,05684292 ! positive regulation of translation GO:0045727 31 19 0,000 0,03883374 0,05680888 ! negative regulation of defense response GO:0031348 27 19 0,000 0,03883374 0,05677489 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,03883374 0,05674093 ! neuron maturation GO:0042551 46 19 0,000 0,03883374 0,05670701 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,03883374 0,05667314 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,03883374 0,0566393 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,03883374 0,05660551 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,03883374 0,05657176 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,03883374 0,05653804 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,03883374 0,05650437 ! memory GO:0007613 34 19 0,000 0,03883374 0,05647073 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,03883374 0,05643714 ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,03883374 0,05640359 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,03883374 0,05637007 ! cerebral cortex development GO:0021987 40 19 0,000 0,03883374 0,0563366 ! pigmentation during development GO:0048066 42 19 0,000 0,03883374 0,05630317 ! response to vitamin A GO:0033189 32 19 0,000 0,03883374 0,05626977 ! heme metabolic process GO:0042168 40 19 0,000 0,03883374 0,05623642 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,03883374 0,0562031 ! response to fungus GO:0009620 26 19 0,000 0,03883374 0,05616982 ! peptide cross-linking GO:0018149 39 19 0,000 0,03883374 0,05613659 ! protein export from nucleus GO:0006611 40 19 0,000 0,03883374 0,05610339 ! heart process GO:0003015 32 19 0,000 0,03883374 0,05607023 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,03883374 0,05603711 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,03883374 0,05600403 ! visual learning GO:0008542 38 19 0,000 0,03883374 0,05597099 ! cellular pigmentation GO:0033059 37 19 0,000 0,03883374 0,05593799 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,03883374 0,05590503 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,03883374 0,0558721 ! vitamin transport GO:0051180 31 19 0,000 0,03883374 0,05583922 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,03883374 0,05580637 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,03883374 0,05577356 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,03883374 0,0557408 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,03883374 0,05570806 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,03883374 0,05567537 ! cilium assembly GO:0042384 38 19 0,000 0,03883374 0,05564272 ! peptide hormone secretion GO:0030072 32 19 0,000 0,03883374 0,0556101 ! protein secretion GO:0009306 45 20 0,000 0,04083589 0,05844293 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,04083589 0,05840871 ! positive regulation of ossification GO:0045778 50 20 0,000 0,04083589 0,05837454 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,04083589 0,0583404 ! skin development GO:0043588 42 20 0,000 0,04083589 0,0583063 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,04083589 0,05827224 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,04083589 0,05823823 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,04083589 0,05820425 ! response to vitamin GO:0033273 36 20 0,000 0,04083589 0,05817031 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,04083589 0,05813641 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,04083589 0,05810255 ! bile acid metabolic process GO:0008206 34 20 0,000 0,04083589 0,05806873 ! response to alkaloid GO:0043279 38 20 0,000 0,04083589 0,05803495 ! retinoid metabolic process GO:0001523 34 20 0,000 0,04083589 0,05800121 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,04083589 0,05796751 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,04083589 0,05793384 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,04083589 0,05790022 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,04083589 0,05786664 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,04083589 0,05783309 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,04083589 0,05779958 ! actin filament bundle formation GO:0051017 47 20 0,000 0,04083589 0,05776612 ! body fluid secretion GO:0007589 33 20 0,000 0,04083589 0,05773269 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,04083589 0,05769929 ! peptide secretion GO:0002790 38 20 0,000 0,04083589 0,05766594 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,04083589 0,05763263 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,04083589 0,05759935 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,04083589 0,05756612 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,04083589 0,05753292 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,04083589 0,05749976 ! cell-cell junction organization GO:0045216 43 20 0,000 0,04083589 0,05746664 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,04083589 0,05743355 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,04083589 0,05740051 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,04083589 0,0573675 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,04083589 0,05733453 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,04083589 0,0573016 ! regulation of glucose import GO:0046324 30 20 0,000 0,04083589 0,0572687 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,04083589 0,05723585 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,04083589 0,05720303 ! negative regulation of translation GO:0017148 32 20 0,000 0,04083589 0,05717025 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,04083589 0,0571375 ! regulation of cell killing GO:0031341 46 21 0,000 0,04283392 0,05989884 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,04283392 0,05986457 ! hormone secretion GO:0046879 39 21 0,000 0,04283392 0,05983035 ! cAMP metabolic process GO:0046058 41 21 0,000 0,04283392 0,05979616 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,04283392 0,05976201 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,04283392 0,0597279 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,04283392 0,05969383 ! ovarian follicle development GO:0001541 39 21 0,000 0,04283392 0,05965979 ! smooth muscle contraction GO:0006939 48 21 0,000 0,04283392 0,0596258 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,04283392 0,05959184 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,04283392 0,05955793 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,04283392 0,05952405 ! plasma membrane fusion GO:0045026 33 21 0,000 0,04283392 0,05949021 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,04283392 0,05945641 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,04283392 0,05942264 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,04283392 0,05938892 ! sensory perception of pain GO:0019233 33 21 0,000 0,04283392 0,05935523 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,04283392 0,05932159 ! diencephalon development GO:0021536 36 21 0,000 0,04283392 0,05928798 ! collagen fibril organization GO:0030199 62 21 0,000 0,04283392 0,0592544 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,04283392 0,05922087 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,04283392 0,05918737 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,04283392 0,05915392 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,04283392 0,0591205 ! collagen catabolic process GO:0030574 29 21 0,000 0,04283392 0,05908711 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,04283392 0,05905377 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,04283392 0,05902046 ! sperm-egg recognition GO:0035036 23 21 0,000 0,04283392 0,05898719 ! actin filament-based movement GO:0030048 47 21 0,000 0,04283392 0,05895396 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,04283392 0,05892076 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,04482785 0,06162884 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,04482785 0,06159417 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,04482785 0,06155955 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,04482785 0,06152497 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,04482785 0,06149042 ! microtubule-based transport GO:0010970 59 22 0,000 0,04482785 0,06145592 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,04482785 0,06142145 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,04482785 0,06138702 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,04482785 0,06135263 ! cellular response to starvation GO:0009267 37 22 0,000 0,04482785 0,06131828 ! vacuolar transport GO:0007034 41 22 0,000 0,04482785 0,06128396 ! central nervous system neuron development GO:0021954 47 22 0,000 0,04482785 0,06124969 ! fucose metabolic process GO:0006004 44 22 0,000 0,04482785 0,06121545 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,04482785 0,06118125 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,04482785 0,06114709 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,04482785 0,06111297 ! ureteric bud development GO:0001657 50 22 0,000 0,04482785 0,06107889 ! stem cell differentiation GO:0048863 57 22 0,000 0,04482785 0,06104484 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,04482785 0,06101083 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,04482785 0,06097686 ! cytolysis GO:0019835 27 22 0,000 0,04482785 0,06094293 ! renal system process GO:0003014 42 22 0,000 0,04482785 0,06090903 ! vasodilation GO:0042311 40 22 0,000 0,04482785 0,06087518 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,04482785 0,06084136 ! G1 phase GO:0051318 44 22 0,000 0,04482785 0,06080757 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,04482785 0,06077383 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,04482785 0,06074012 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,04482785 0,06070645 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,04482785 0,06067282 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,04482785 0,06063923 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,04482785 0,06060567 ! sarcomere organization GO:0045214 32 22 0,000 0,04482785 0,06057215 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,04482785 0,06053866 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,04482785 0,06050522 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,04482785 0,06047181 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,04482785 0,06043843 ! gut development GO:0048565 44 22 0,000 0,04482785 0,0604051 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,04482785 0,0603718 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,04482785 0,06033854 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,04482785 0,06030531 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,04681768 0,06294749 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,04681768 0,06291287 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,04681768 0,06287828 ! gluconeogenesis GO:0006094 38 23 0,000 0,04681768 0,06284373 ! glycerol metabolic process GO:0006071 40 23 0,000 0,04681768 0,06280922 ! viral genome replication GO:0019079 44 23 0,000 0,04681768 0,06277475 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,04681768 0,06274032 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,04681768 0,06270592 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,04681768 0,06267156 ! regeneration GO:0031099 42 23 0,000 0,04681768 0,06263724 ! axis specification GO:0009798 43 23 0,000 0,04681768 0,06260295 ! visual behavior GO:0007632 46 23 0,000 0,04681768 0,06256871 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,04681768 0,0625345 ! response to ethanol GO:0045471 47 23 0,000 0,04681768 0,06250033 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,04681768 0,06246619 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,04681768 0,06243209 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,04681768 0,06239803 ! peroxisome organization GO:0007031 43 23 0,000 0,04681768 0,06236401 ! lysosome organization GO:0007040 47 23 0,000 0,04681768 0,06233003 ! vesicle targeting GO:0006903 49 23 0,000 0,04681768 0,06229608 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,04681768 0,06226216 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,04681768 0,06222829 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,04681768 0,06219445 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,04681768 0,06216065 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,04681768 0,06212689 ! DNA modification GO:0006304 36 23 0,000 0,04681768 0,06209316 ! fatty acid transport GO:0015908 47 23 0,000 0,04681768 0,06205947 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,04681768 0,06202581 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,04681768 0,06199219 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,04681768 0,06195861 ! hormone transport GO:0009914 41 23 0,000 0,04681768 0,06192507 ! cell-cell recognition GO:0009988 28 23 0,000 0,04681768 0,06189156 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,04681768 0,06185808 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,04681768 0,06182465 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,04681768 0,06179125 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,04880342 0,0643773 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,04880342 0,06434256 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,04880342 0,06430785 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,04880342 0,06427319 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,04880342 0,06423856 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,04880342 0,06420396 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,04880342 0,06416941 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,04880342 0,06413489 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,04880342 0,06410041 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,04880342 0,06406596 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,04880342 0,06403156 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,04880342 0,06399719 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,04880342 0,06396285 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,04880342 0,06392856 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,04880342 0,0638943 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,04880342 0,06386008 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,04880342 0,06382589 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,04880342 0,06379174 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,04880342 0,06375763 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,04880342 0,06372355 ! membrane depolarization GO:0051899 45 24 0,000 0,04880342 0,06368951 ! pallium development GO:0021543 56 24 0,000 0,04880342 0,0636555 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,04880342 0,06362154 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,04880342 0,06358761 ! platelet activation GO:0030168 41 24 0,000 0,04880342 0,06355371 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,04880342 0,06351985 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,04880342 0,06348603 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,04880342 0,06345224 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,04880342 0,06341849 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,04880342 0,06338477 ! regulation of amine transport GO:0051952 41 24 0,000 0,04880342 0,06335109 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,04880342 0,06331745 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,05078508 0,06585348 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,05078508 0,06581854 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,05078508 0,06578365 ! leukocyte adhesion GO:0007159 55 25 0,000 0,05078508 0,06574878 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,05078508 0,06571396 ! phototransduction GO:0007602 37 25 0,000 0,05078508 0,06567917 ! keratinization GO:0031424 37 25 0,000 0,05078508 0,06564442 ! vacuole organization GO:0007033 49 25 0,000 0,05078508 0,06560971 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,05078508 0,06557503 ! chromosome condensation GO:0030261 48 25 0,000 0,05078508 0,06554039 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,05078508 0,06550578 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,05078508 0,06547122 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,05078508 0,06543669 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,05078508 0,06540219 ! immunoglobulin production GO:0002377 62 25 0,000 0,05078508 0,06536773 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,05078508 0,06533331 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,05078508 0,06529892 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,05078508 0,06526457 ! liver development GO:0001889 55 25 0,000 0,05078508 0,06523026 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,05276267 0,06773473 ! initiation of viral infection GO:0019059 60 26 0,000 0,05276267 0,06769916 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,05276267 0,06766362 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,05276267 0,06762812 ! molting cycle process GO:0022404 52 26 0,000 0,05276267 0,06759266 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,05276267 0,06755723 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,05276267 0,06752184 GO:0006479|protein amino acid methylation, ! spinal cord development GO:0021510 54 26 0,000 0,05276267 0,06748649 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,05276267 0,06745118 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,05276267 0,0674159 ! digestive system process GO:0022600 49 26 0,000 0,05276267 0,06738066 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,05276267 0,06734545 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,05276267 0,06731029 ! osteoblast differentiation GO:0001649 63 26 0,000 0,05276267 0,06727516 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,05276267 0,06724006 ! neural crest cell development GO:0014032 59 26 0,000 0,05276267 0,067205 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,05276267 0,06716998 ! negative regulation of cell development GO:0010721 83 26 0,000 0,05276267 0,067135 GO:0050768|negative regulation of neurogenesis, ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,05276267 0,06710005 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,05276267 0,06706514 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,05276267 0,06703026 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,05276267 0,06699543 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,05276267 0,06696062 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,05276267 0,06692586 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,05276267 0,06689113 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,05276267 0,06685643 ! telomere organization GO:0032200 46 26 0,000 0,05276267 0,06682177 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,05276267 0,06678715 ! neural tube closure GO:0001843 58 26 0,000 0,05276267 0,06675256 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,05276267 0,06671801 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,05276267 0,0666835 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,05276267 0,06664902 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,05473619 0,06910621 ! embryonic pattern specification GO:0009880 49 27 0,000 0,05473619 0,06907051 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,05473619 0,06903485 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,05473619 0,06899923 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,05473619 0,06896365 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,05473619 0,0689281 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,05473619 0,06889259 ! iron ion transport GO:0006826 65 27 0,000 0,05473619 0,06885711 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,05473619 0,06882167 ! superoxide metabolic process GO:0006801 41 27 0,000 0,05473619 0,06878627 ! tube lumen formation GO:0035148 59 27 0,000 0,05473619 0,06875091 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,05473619 0,06871558 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,05473619 0,06868028 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,05473619 0,06864503 ! response to starvation GO:0042594 47 27 0,000 0,05473619 0,06860981 ! response to toxin GO:0009636 49 27 0,000 0,05473619 0,06857462 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,05473619 0,06853947 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,05473619 0,06850436 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,05473619 0,06846929 ! leukocyte proliferation GO:0070661 59 27 0,000 0,05473619 0,06843424 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,05670566 0,07086032 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,05670566 0,07082409 ! vesicle docking GO:0048278 55 28 0,000 0,05670566 0,0707879 ! circadian rhythm GO:0007623 56 28 0,000 0,05670566 0,07075175 ! dendrite development GO:0016358 67 28 0,000 0,05670566 0,07071563 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,05670566 0,07067955 ! fat cell differentiation GO:0045444 57 28 0,000 0,05670566 0,07064351 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,05670566 0,0706075 ! sperm motility GO:0030317 37 28 0,000 0,05670566 0,07057153 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,05670566 0,0705356 ! base-excision repair GO:0006284 41 28 0,000 0,05670566 0,0704997 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,05670566 0,07046385 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,05670566 0,07042802 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,05670566 0,07039224 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,05670566 0,07035649 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,05670566 0,07032077 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,05670566 0,07028509 ! glutathione metabolic process GO:0006749 42 28 0,000 0,05670566 0,07024945 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,05670566 0,07021385 ! lipid oxidation GO:0034440 48 28 0,000 0,05670566 0,07017828 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,05670566 0,07014274 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,05670566 0,07010725 ! translational initiation GO:0006413 66 29 0,000 0,05867107 0,07250047 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,05867107 0,07246382 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,05867107 0,0724272 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,05867107 0,07239062 ! autophagy GO:0006914 47 29 0,000 0,05867107 0,07235408 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,05867107 0,07231758 ! primary neural tube formation GO:0014020 61 29 0,000 0,05867107 0,07228111 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,05867107 0,07224468 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,05867107 0,07220828 ! synaptogenesis GO:0007416 46 29 0,000 0,05867107 0,07217192 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,05867107 0,0721356 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,05867107 0,07209931 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,05867107 0,07206306 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,05867107 0,07202685 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,06063245 0,07439733 ! phenol metabolic process GO:0018958 56 30 0,000 0,06063245 0,07435998 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,06063245 0,07432267 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,06063245 0,0742854 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,06063245 0,07424816 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,06063245 0,07421096 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,06063245 0,0741738 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,06063245 0,07413668 ! acute-phase response GO:0006953 50 30 0,000 0,06063245 0,07409959 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,06063245 0,07406254 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,06063245 0,07402553 ! myofibril assembly GO:0030239 50 30 0,000 0,06063245 0,07398855 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,06063245 0,07395161 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,06063245 0,07391471 ! cell fate determination GO:0001709 64 30 0,000 0,06063245 0,07387785 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,06063245 0,07384102 ! phospholipid transport GO:0015914 65 30 0,000 0,06063245 0,07380423 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,06063245 0,07376747 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,06063245 0,07373075 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,06063245 0,07369407 ! regulation of coagulation GO:0050818 52 30 0,000 0,06063245 0,07365743 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,0625898 0,07599745 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,0625898 0,0759597 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,0625898 0,07592199 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,0625898 0,07588431 ! cell junction assembly GO:0034329 85 31 0,000 0,0625898 0,07584667 ! regulation of innate immune response GO:0045088 57 31 0,000 0,0625898 0,07580906 ! ovulation cycle process GO:0022602 55 31 0,000 0,0625898 0,0757715 ! peptide transport GO:0015833 60 31 0,000 0,0625898 0,07573397 ! male gonad development GO:0008584 56 31 0,000 0,0625898 0,07569647 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,0625898 0,07565902 ! detection of light stimulus GO:0009583 44 31 0,000 0,0625898 0,0756216 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,0625898 0,07558422 ! natural killer cell activation GO:0030101 50 31 0,000 0,0625898 0,07554688 ! cofactor catabolic process GO:0051187 54 31 0,000 0,0625898 0,07550957 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,0625898 0,0754723 ! eye morphogenesis GO:0048592 65 31 0,000 0,0625898 0,07543507 ! response to heat GO:0009408 54 31 0,000 0,0625898 0,07539787 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,0625898 0,07536071 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,06454312 0,07767431 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,06454312 0,07763606 ! collagen metabolic process GO:0032963 49 32 0,000 0,06454312 0,07759786 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,06454312 0,07755969 ! spindle organization GO:0007051 50 32 0,000 0,06454312 0,07752156 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,06454312 0,07748346 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,06454312 0,07744541 ! metanephros development GO:0001656 81 32 0,000 0,06454312 0,07740739 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,06454312 0,0773694 ! muscle cell development GO:0055001 52 32 0,000 0,06454312 0,07733146 ! mesoderm formation GO:0001707 73 32 0,000 0,06454312 0,07729355 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,06454312 0,07725568 ! ovulation cycle GO:0042698 57 32 0,000 0,06454312 0,07721785 ! BMP signaling pathway GO:0030509 71 32 0,000 0,06454312 0,07718005 ! hindbrain development GO:0030902 65 32 0,000 0,06454312 0,07714229 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,06454312 0,07710457 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,06454312 0,07706688 ! gene silencing GO:0016458 71 32 0,000 0,06454312 0,07702924 ! regulation of pH GO:0006885 56 33 0,000 0,06649243 0,0793169 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,06649243 0,07927819 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,06649243 0,07923951 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,06649243 0,07920088 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,06649243 0,07916228 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,06649243 0,07912372 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,06649243 0,0790852 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,06649243 0,07904672 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,06649243 0,07900827 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,06649243 0,07896986 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,06649243 0,07893149 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,06649243 0,07889315 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,06649243 0,07885486 ! glial cell differentiation GO:0010001 67 34 0,000 0,06843773 0,08112245 ! post-embryonic development GO:0009791 76 34 0,000 0,06843773 0,08108311 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,06843773 0,08104381 ! cholesterol transport GO:0030301 62 34 0,000 0,06843773 0,08100454 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,06843773 0,08096531 ! spliceosome assembly GO:0000245 75 34 0,000 0,06843773 0,08092612 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,06843773 0,08088697 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,06843773 0,08084786 ! formation of primary germ layer GO:0001704 76 34 0,000 0,06843773 0,08080878 ! cell fate specification GO:0001708 56 34 0,000 0,06843773 0,08076975 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,06843773 0,08073075 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,06843773 0,08069178 ! adult locomotory behavior GO:0008344 62 34 0,000 0,06843773 0,08065286 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,07037903 0,08290066 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,07037903 0,08286071 ! negative regulation of secretion GO:0051048 68 35 0,000 0,07037903 0,0828208 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,07037903 0,08278092 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,07037903 0,08274108 ! membrane docking GO:0022406 69 35 0,000 0,07037903 0,08270129 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,07037903 0,08266153 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,07037903 0,0826218 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,07037903 0,08258212 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,07037903 0,08254247 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,07037903 0,08250287 ! ceramide metabolic process GO:0006672 72 35 0,000 0,07037903 0,0824633 ! telencephalon development GO:0021537 81 35 0,000 0,07037903 0,08242376 ! sterol transport GO:0015918 63 35 0,000 0,07037903 0,08238427 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,07037903 0,08234481 ! placenta development GO:0001890 53 35 0,000 0,07037903 0,0823054 ! vesicle localization GO:0051648 70 35 0,000 0,07037903 0,08226602 ! regulation of muscle development GO:0048634 82 36 0,000 0,07231634 0,08449011 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,07231634 0,08444972 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,07231634 0,08440937 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,07231634 0,08436906 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,07231634 0,08432879 ! positive regulation of cell development GO:0010720 85 36 0,000 0,07231634 0,08428856 ! protein targeting to membrane GO:0006612 75 36 0,000 0,07231634 0,08424837 ! regulation of proteolysis GO:0030162 77 36 0,000 0,07231634 0,08420821 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,07231634 0,08416809 ! aerobic respiration GO:0009060 56 36 0,000 0,07231634 0,08412801 ! cytokine production GO:0001816 68 36 0,000 0,07231634 0,08408797 ! embryonic organ development GO:0048568 67 36 0,000 0,07231634 0,08404796 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,07231634 0,084008 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,07231634 0,08396807 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,07424967 0,08617194 ! sister chromatid segregation GO:0000819 65 37 0,000 0,07424967 0,08613103 ! odontogenesis GO:0042476 74 37 0,000 0,07424967 0,08609015 ! actomyosin structure organization GO:0031032 68 37 0,000 0,07424967 0,08604931 ! cell junction organization GO:0034330 96 37 0,000 0,07424967 0,08600851 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,07424967 0,08596774 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,07424967 0,08592702 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,07424967 0,08588634 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,07617902 0,08807636 ! meiosis I GO:0007127 74 38 0,000 0,07617902 0,0880347 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,07617902 0,08799307 ! organic anion transport GO:0015711 82 38 0,000 0,07617902 0,08795149 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,07617902 0,08790994 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,07617902 0,08786844 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,07617902 0,08782697 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,07617902 0,08778554 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,07617902 0,08774415 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,07617902 0,0877028 ! spermatid development GO:0007286 69 38 0,000 0,07617902 0,08766149 ! glycogen metabolic process GO:0005977 63 38 0,000 0,07617902 0,08762022 ! pigment metabolic process GO:0042440 87 38 0,000 0,07617902 0,08757899 ! neural tube formation GO:0001841 79 38 0,000 0,07617902 0,08753779 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,07810441 0,08970807 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,07810441 0,08966591 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,07810441 0,0896238 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,07810441 0,08958172 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,07810441 0,08953968 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,07810441 0,08949769 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,07810441 0,08945573 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,07810441 0,08941381 ! glucan metabolic process GO:0044042 64 39 0,000 0,07810441 0,08937193 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,08002583 0,09152767 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,08002583 0,09148484 ! learning GO:0007612 82 40 0,000 0,08002583 0,09144206 ! nucleus organization GO:0006997 73 40 0,000 0,08002583 0,09139931 ! lipid homeostasis GO:0055088 75 40 0,000 0,08002583 0,0913566 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,08002583 0,09131393 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,08002583 0,09127129 ! RNA export from nucleus GO:0006405 61 41 0,000 0,08194331 0,09341461 ! mRNA catabolic process GO:0006402 79 41 0,000 0,08194331 0,09337104 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,08194331 0,09332751 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,08194331 0,09328402 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,08194331 0,09324057 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,08194331 0,09319716 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,08194331 0,0931538 ! gliogenesis GO:0042063 91 41 0,000 0,08194331 0,09311047 ! feeding behavior GO:0007631 69 41 0,000 0,08194331 0,09306718 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,08194331 0,09302394 ! mesenchymal cell development GO:0014031 94 41 0,000 0,08194331 0,09298073 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,08194331 0,09293756 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,08194331 0,09289444 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,08194331 0,09285135 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,08194331 0,0928083 ! RNA modification GO:0009451 64 41 0,000 0,08194331 0,0927653 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,08385685 0,09488757 ! ear morphogenesis GO:0042471 64 42 0,000 0,08385685 0,09484364 ! organic ether metabolic process GO:0018904 59 42 0,000 0,08385685 0,09479976 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,08385685 0,09475591 ! T cell differentiation GO:0030217 93 42 0,000 0,08385685 0,0947121 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,08385685 0,09466833 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,08385685 0,09462461 ! regulation of protein secretion GO:0050708 77 42 0,000 0,08385685 0,09458092 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,08385685 0,09453727 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,08385685 0,09449367 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,08576644 0,09660093 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,08576644 0,09655642 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,08576644 0,09651194 ! regulation of tube size GO:0035150 76 43 0,000 0,08576644 0,09646751 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,08576644 0,09642311 ! glucose transport GO:0015758 66 43 0,000 0,08576644 0,09637876 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,08576644 0,09633445 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,08576644 0,09629018 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,08576644 0,09624595 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,08576644 0,09620176 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,08576644 0,09615761 ! ion transmembrane transport GO:0034220 79 43 0,000 0,08576644 0,0961135 ! neuron migration GO:0001764 85 43 0,000 0,08576644 0,09606943 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,08576644 0,0960254 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,08767212 0,09811405 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,08767212 0,09806913 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,08767212 0,09802425 ! hexose transport GO:0008645 68 44 0,000 0,08767212 0,09797941 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,08767212 0,09793461 ! striated muscle contraction GO:0006941 85 44 0,000 0,08767212 0,09788985 ! phagocytosis GO:0006909 105 44 0,000 0,08767212 0,09784513 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,08767212 0,09780045 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,08957387 0,0998763 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,08957387 0,09983073 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,08957387 0,09978521 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,08957387 0,09973973 ! biopolymer methylation GO:0043414 91 45 0,000 0,08957387 0,09969429 ! B cell differentiation GO:0030183 124 45 0,000 0,08957387 0,09964889 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,08957387 0,09960353 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,08957387 0,09955822 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,09147171 0,10162137 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,09147171 0,10157518 ! glycolysis GO:0006096 71 46 0,000 0,09147171 0,10152903 ! leukocyte migration GO:0050900 75 46 0,000 0,09147171 0,10148292 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,09147171 0,10143686 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,09147171 0,10139083 ! pigmentation GO:0043473 103 46 0,000 0,09147171 0,10134485 ! cell growth GO:0016049 90 46 0,000 0,09147171 0,10129891 ! neural tube development GO:0021915 91 47 0,000 0,09336565 0,10334948 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,09336565 0,10330267 ! positive regulation of defense response GO:0031349 88 48 0,000 0,0952557 0,10534616 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,0952557 0,1052985 ! mitochondrial transport GO:0006839 94 48 0,000 0,0952557 0,10525087 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,0952557 0,10520329 ! cellular component disassembly GO:0022411 89 48 0,000 0,0952557 0,10515575 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,0952557 0,10510825 ! male sex differentiation GO:0046661 93 48 0,000 0,0952557 0,1050608 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,0952557 0,10501339 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,0952557 0,10496602 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,0952557 0,1049187 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,0952557 0,10487142 ! methylation GO:0032259 97 48 0,000 0,0952557 0,10482418 ! response to calcium ion GO:0051592 94 49 0,000 0,09714186 0,10685167 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,09714186 0,10680358 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,09714186 0,10675554 ! JNK cascade GO:0007254 106 49 0,000 0,09714186 0,10670754 ! protein homooligomerization GO:0051260 84 49 0,000 0,09714186 0,10665958 ! regulation of ion transport GO:0043269 86 50 0,000 0,09902414 0,10867743 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,09902414 0,10862863 ! endocrine system development GO:0035270 109 50 0,000 0,09902414 0,10857988 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,09902414 0,10853117 ! activation of caspase activity GO:0006919 95 50 0,000 0,09902414 0,1084825 ! regulation of ossification GO:0030278 123 50 0,000 0,09902414 0,10843387 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,09902414 0,10838529 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,09902414 0,10833675 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,09902414 0,10828826 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,09902414 0,10823981 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,09902414 0,1081914 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,10090255 0,11019442 ! viral infectious cycle GO:0019058 104 51 0,000 0,10090255 0,11014518 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,10090255 0,11009599 ! peptide metabolic process GO:0006518 80 51 0,000 0,10090255 0,11004684 ! response to temperature stimulus GO:0009266 84 51 0,000 0,10090255 0,10999773 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,10090255 0,10994867 ! Notch signaling pathway GO:0007219 111 52 0,000 0,10277709 0,11194134 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,10277709 0,11189146 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,10277709 0,11184162 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,10277709 0,11179182 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,10277709 0,11174207 ! excretion GO:0007588 87 52 0,000 0,10277709 0,11169236 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,10277709 0,1116427 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,10277709 0,11159308 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,10277709 0,11154351 ! amino acid activation GO:0043038 98 52 0,000 0,10277709 0,11149397 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,10464778 0,11347294 ! inner ear development GO:0048839 89 53 0,000 0,10464778 0,11342259 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,10464778 0,11337229 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,10464778 0,11332204 ! vesicle organization GO:0016050 127 53 0,000 0,10464778 0,11327183 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,10464778 0,11322167 ! regulation of translational initiation GO:0006446 87 54 0,000 0,10651462 0,11519045 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,10651462 0,11513948 ! neuromuscular process GO:0050905 107 54 0,000 0,10651462 0,11508855 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,10651462 0,11503767 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,10651462 0,11498684 ! membrane fusion GO:0006944 122 54 0,000 0,10651462 0,11493605 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,10651462 0,11488531 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,10651462 0,11483461 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,10651462 0,11478395 ! RNA catabolic process GO:0006401 103 55 0,000 0,10837762 0,11674009 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,10837762 0,11668864 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,10837762 0,11663724 ! cell recognition GO:0008037 98 55 0,000 0,10837762 0,11658588 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,10837762 0,11653456 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,10837762 0,1164833 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,11023679 0,11842941 ! glucose catabolic process GO:0006007 88 56 0,000 0,11023679 0,11837735 ! RNA elongation GO:0006354 90 56 0,000 0,11023679 0,11832534 ! chloride transport GO:0006821 102 57 0,000 0,11209214 0,12026398 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,11209214 0,12021119 GO:0010952|positive regulation of peptidase activity, ! regulation of actin filament length GO:0030832 118 58 0,000 0,11394366 0,12214321 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,11394366 0,12208964 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,11394366 0,12203611 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,11394366 0,12198263 ! gastrulation GO:0007369 122 58 0,000 0,11394366 0,1219292 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,11394366 0,12187582 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,11394366 0,12182248 ! nuclear export GO:0051168 110 59 0,000 0,11579138 0,12374381 ! establishment of organelle localization GO:0051656 122 59 0,000 0,11579138 0,1236897 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,1176353 0,12560448 ! DNA catabolic process GO:0006308 94 60 0,000 0,1176353 0,1255496 ! regulation of endocytosis GO:0030100 104 60 0,000 0,1176353 0,12549478 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,1176353 0,12544 ! adult behavior GO:0030534 104 60 0,000 0,1176353 0,12538527 ! kidney development GO:0001822 133 60 0,000 0,1176353 0,12533059 ! positive regulation of secretion GO:0051047 110 61 0,000 0,11947543 0,1272356 ! regulation of cellular component size GO:0032535 125 61 0,000 0,11947543 0,12718016 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,11947543 0,12712477 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,11947543 0,12706942 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,11947543 0,12701413 ! regulation of heart contraction GO:0008016 123 61 0,000 0,11947543 0,12695888 ! camera-type eye development GO:0043010 126 61 0,000 0,11947543 0,12690368 ! proton transport GO:0015992 117 61 0,000 0,11947543 0,12684853 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,11947543 0,12679343 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,12131177 0,12868634 ! tRNA processing GO:0008033 102 62 0,000 0,12131177 0,12863049 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,12314433 0,13051696 ! regulation of mitosis GO:0007088 112 63 0,000 0,12314433 0,13046036 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,12314433 0,13040381 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,12314433 0,13034731 ! hydrogen transport GO:0006818 121 64 0,000 0,12497312 0,13222578 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,12497312 0,13216854 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,12679814 0,13404062 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,12679814 0,13398264 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,12679814 0,13392472 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,12679814 0,13386684 ! ear development GO:0043583 114 66 0,000 0,12861942 0,13573099 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,12861942 0,13567238 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,12861942 0,13561383 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,12861942 0,13555532 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,13043694 0,13741158 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,13043694 0,13735235 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,13043694 0,13729317 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,13043694 0,13723404 ! secondary metabolic process GO:0019748 125 67 0,000 0,13043694 0,13717497 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,13043694 0,13711594 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,13225073 0,13896281 ! hexose catabolic process GO:0019320 113 68 0,000 0,13225073 0,13890307 ! extracellular matrix organization GO:0030198 146 68 0,000 0,13225073 0,13884337 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,13225073 0,13878373 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,13225073 0,13872414 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,13225073 0,1386646 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,13225073 0,13860512 ! cell projection assembly GO:0030031 138 68 0,000 0,13225073 0,13854568 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,13406078 0,14038169 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,13406078 0,14032155 ! urogenital system development GO:0001655 149 69 0,000 0,13406078 0,14026145 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,13406078 0,14020141 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,13406078 0,14014142 ! single fertilization GO:0007338 83 69 0,000 0,13406078 0,14008148 ! cell redox homeostasis GO:0045454 114 70 0,000 0,13586711 0,14190823 ! activation of immune response GO:0002253 120 70 0,000 0,13586711 0,14184759 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,13586711 0,14178699 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,13766972 0,1436068 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,13766972 0,14354551 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,13766972 0,14348427 ! appendage morphogenesis GO:0035107 150 72 0,000 0,13946862 0,14529716 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,13946862 0,14523523 ! B cell activation GO:0042113 179 72 0,000 0,13946862 0,14517335 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,13946862 0,14511152 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,13946862 0,14504974 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,13946862 0,14498802 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,13946862 0,14492635 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,13946862 0,14486473 ! appendage development GO:0048736 151 73 0,000 0,14126382 0,14666703 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,14126382 0,14660472 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,14126382 0,14654247 ! regulation of immune effector process GO:0002697 156 73 0,000 0,14126382 0,14648027 ! acute inflammatory response GO:0002526 118 74 0,000 0,14305533 0,148275 ! amino acid transport GO:0006865 148 74 0,000 0,14305533 0,14821211 ! regulation of caspase activity GO:0043281 136 74 0,000 0,14305533 0,14814929 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,14305533 0,14808651 ! organelle localization GO:0051640 155 74 0,000 0,14305533 0,14802379 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,14484315 0,14981025 ! eye development GO:0001654 155 75 0,000 0,14484315 0,14974685 ! rhythmic process GO:0048511 142 75 0,000 0,14484315 0,1496835 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,14662728 0,15146319 ! learning or memory GO:0007611 161 76 0,000 0,14662728 0,15139918 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,14662728 0,15133522 ! regulation of blood pressure GO:0008217 134 76 0,000 0,14662728 0,15127131 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,14662728 0,15120745 ! amine catabolic process GO:0009310 136 77 0,000 0,14840775 0,15297896 ! neurotransmitter transport GO:0006836 142 77 0,000 0,14840775 0,15291444 ! regulation of endopeptidase activity GO:0052548 141 77 0,000 0,14840775 0,15284997 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,14840775 0,15278556 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,14840775 0,1527212 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,14840775 0,1526569 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,14840775 0,15259265 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,15018455 0,15435459 ! antigen processing and presentation GO:0019882 117 78 0,000 0,15018455 0,15428968 ! fertilization GO:0009566 99 78 0,000 0,15018455 0,15422483 ! blood coagulation GO:0007596 151 79 0,000 0,1519577 0,15598011 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,1519577 0,1559146 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,1519577 0,15584914 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,1519577 0,15578374 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,1519577 0,15571839 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,15372719 0,15746563 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,15372719 0,15739963 ! muscle cell differentiation GO:0042692 178 81 0,000 0,15549304 0,15914097 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,15549304 0,15907433 ! regulation of peptidase activity GO:0052547 150 82 0,000 0,15725526 0,1608098 ! protein import into nucleus GO:0006606 174 82 0,000 0,15725526 0,16074251 ! exocytosis GO:0006887 153 83 0,000 0,15901385 0,16247212 ! response to drug GO:0042493 149 83 0,000 0,15901385 0,1624042 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,15901385 0,16233633 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,15901385 0,16226852 ! nuclear import GO:0051170 177 83 0,000 0,15901385 0,16220077 ! inorganic anion transport GO:0015698 156 83 0,000 0,15901385 0,16213307 ! response to metal ion GO:0010038 158 84 0,000 0,16076882 0,16385408 ! T cell activation GO:0042110 189 84 0,000 0,16076882 0,16378575 ! digestion GO:0007586 130 84 0,000 0,16076882 0,16371748 ! regulation of ligase activity GO:0051340 147 84 0,000 0,16076882 0,16364926 ! hemostasis GO:0007599 165 85 0,000 0,16252018 0,1653631 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,16252018 0,16529425 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,16252018 0,16522547 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,16252018 0,16515674 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,16601208 0,16863514 ! mitochondrion organization GO:0007005 159 87 0,000 0,16601208 0,16856505 ! alcohol catabolic process GO:0046164 142 87 0,000 0,16601208 0,16849502 ! nucleosome assembly GO:0006334 126 87 0,000 0,16601208 0,16842505 ! cellular respiration GO:0045333 143 88 0,000 0,16775264 0,17012026 ! amine biosynthetic process GO:0009309 146 88 0,000 0,16775264 0,17004967 ! sensory perception of smell GO:0007608 117 88 0,000 0,16775264 0,16997914 ! chromatin assembly GO:0031497 128 88 0,000 0,16775264 0,16990867 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,16775264 0,16983825 ! tube morphogenesis GO:0035239 194 89 0,000 0,16948962 0,17152574 ! cellular defense response GO:0006968 123 89 0,000 0,16948962 0,17145472 ! protein localization in nucleus GO:0034504 192 89 0,000 0,16948962 0,17138375 ! regulation of neurological system process GO:0031644 175 89 0,000 0,16948962 0,17131284 ! response to inorganic substance GO:0010035 173 90 0,000 0,17122302 0,17299332 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,17122302 0,17292181 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,17122302 0,17285035 ! response to unfolded protein GO:0006986 139 90 0,000 0,17122302 0,17277895 ! defense response to bacterium GO:0042742 112 91 0,000 0,17295286 0,17445245 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,17467913 0,17612097 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,17640184 0,17778453 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,17640184 0,17771122 ! vitamin metabolic process GO:0006766 153 93 0,000 0,17640184 0,17763797 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,17812101 0,17929528 ! female pregnancy GO:0007565 166 94 0,000 0,17812101 0,17922143 ! sterol metabolic process GO:0016125 166 94 0,000 0,17812101 0,17914765 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,17812101 0,17907392 ! regulation of defense response GO:0031347 171 95 0,000 0,17983664 0,18072436 ! nucleosome organization GO:0034728 143 95 0,000 0,17983664 0,18065005 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,17983664 0,1805758 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,17983664 0,18050161 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,17983664 0,18042748 ! response to protein stimulus GO:0051789 158 96 0,000 0,18154874 0,18207043 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,18325731 0,1837085 ! transcription initiation GO:0006352 171 97 0,000 0,18325731 0,18363314 ! leukocyte differentiation GO:0002521 232 98 0,000 0,18496236 0,1852657 ! forebrain development GO:0030900 210 98 0,000 0,18496236 0,18518977 ! mRNA transport GO:0051028 185 100 0,000 0,18836194 0,18851627 ! positive regulation of immune response GO:0050778 175 100 0,000 0,18836194 0,18843907 ! hormone metabolic process GO:0042445 171 100 0,000 0,18836194 0,18836194