pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6474-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! apoptotic mitochondrial changes GO:0008637 42 20 5,000 1,893E-09 4,625E-06 ! apoptotic nuclear changes GO:0030262 34 22 5,000 3,607E-09 4,406E-06 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 3,000 7,106E-09 5,787E-06 ! release of cytochrome c from mitochondria GO:0001836 31 14 4,000 1,661E-08 1,014E-05 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 4,000 5,055E-08 2,47E-05 ! cell-substrate junction assembly GO:0007044 56 18 4,000 6,965E-08 2,836E-05 ! cell structure disassembly during apoptosis GO:0006921 32 21 4,000 1,629E-07 5,686E-05 ! nucleus organization GO:0006997 73 40 5,000 1,691E-07 5,163E-05 ! interphase of mitotic cell cycle GO:0051329 224 98 7,000 1,85E-07 5,022E-05 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 3,000 2,913E-07 7,116E-05 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 4,000 3,352E-07 7,444E-05 ! induction of apoptosis by intracellular signals GO:0008629 95 45 5,000 3,497E-07 7,119E-05 ! developmental growth GO:0048589 88 45 5,000 3,497E-07 6,571E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 4E-07 6,981E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 3,000 4,555E-07 7,419E-05 ! peptide or protein amino-terminal blocking GO:0018409 22 11 3,000 4,555E-07 6,955E-05 ! insulin receptor signaling pathway GO:0008286 66 27 4,000 6,271E-07 9,012E-05 ! regulation of B cell proliferation GO:0030888 22 12 3,000 6,799E-07 9,228E-05 ! focal adhesion formation GO:0048041 37 12 3,000 6,799E-07 8,743E-05 ! negative regulation of mast cell proliferation GO:0070667 24 12 3,000 6,799E-07 8,306E-05 GO:0042130|negative regulation of T cell proliferation, ! covalent chromatin modification GO:0016569 115 54 5,000 1,058E-06 1,231E-04 ! response to UV GO:0009411 120 55 5,000 1,182E-06 1,313E-04 ! mitochondrion organization GO:0007005 159 87 6,000 1,214E-06 1,29E-04 ! cell junction assembly GO:0034329 85 31 4,000 1,293E-06 1,317E-04 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 3,000 1,362E-06 1,331E-04 GO:0060675|ureteric bud morphogenesis, ! response to gamma radiation GO:0010332 30 14 3,000 1,362E-06 1,279E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 1,464E-06 1,325E-04 ! gland development GO:0048732 220 91 6,000 1,647E-06 1,437E-04 ! N-terminal protein amino acid modification GO:0031365 30 15 3,000 1,848E-06 1,557E-04 ! negative regulation of survival gene product expression GO:0008634 9 5 2,000 2,318E-06 1,887E-04 ! B cell homeostasis GO:0001782 13 5 2,000 2,318E-06 1,827E-04 ! negative regulation of leukocyte proliferation GO:0070664 32 16 3,000 2,452E-06 1,872E-04 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! response to peptide hormone stimulus GO:0043434 129 64 5,000 2,918E-06 2,16E-04 ! cell junction organization GO:0034330 96 37 4,000 3,22E-06 2,313E-04 ! cellular response to insulin stimulus GO:0032869 85 38 4,000 3,689E-06 2,575E-04 ! neuron apoptosis GO:0051402 15 6 2,000 4,614E-06 3,131E-04 ! neural nucleus development GO:0048857 19 6 2,000 4,614E-06 3,047E-04 ! negative regulation of B cell activation GO:0050869 14 6 2,000 4,614E-06 2,967E-04 ! regulation of intracellular protein transport GO:0033157 86 42 4,000 6,127E-06 3,838E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 3,000 6,401E-06 3,91E-04 ! actin filament bundle formation GO:0051017 47 20 3,000 6,401E-06 3,814E-04 ! negative regulation of T cell activation GO:0050868 41 20 3,000 6,401E-06 3,723E-04 ! cytokinesis during cell cycle GO:0033205 14 7 2,000 8,038E-06 4,567E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 8,038E-06 4,463E-04 ! N-terminal protein amino acid acetylation GO:0006474 14 7 2,000 8,038E-06 4,364E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 8,038E-06 4,269E-04 ! cranial nerve morphogenesis GO:0021602 12 7 2,000 8,038E-06 4,178E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 8,038E-06 4,091E-04 ! branching morphogenesis of a tube GO:0048754 102 45 4,000 8,668E-06 4,322E-04 ! ureteric bud development GO:0001657 50 22 3,000 9,571E-06 4,676E-04 ! cell aging GO:0007569 48 22 3,000 9,571E-06 4,585E-04 ! positive regulation of intracellular transport GO:0032388 42 22 3,000 9,571E-06 4,497E-04 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 4,000 9,676E-06 4,46E-04 ! response to insulin stimulus GO:0032868 98 47 4,000 1,077E-05 4,874E-04 ! regulation of cell-matrix adhesion GO:0001952 81 23 3,000 1,153E-05 5,121E-04 GO:0010810|regulation of cell-substrate adhesion, ! cellular component disassembly GO:0022411 89 48 4,000 1,197E-05 5,22E-04 ! male meiosis GO:0007140 9 8 2,000 1,28E-05 5,487E-04 ! ER overload response GO:0006983 13 8 2,000 1,28E-05 5,392E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,28E-05 5,301E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,28E-05 5,213E-04 ! blastocyst growth GO:0001832 19 8 2,000 1,28E-05 5,127E-04 ! regulation of mast cell proliferation GO:0070666 89 49 4,000 1,326E-05 5,225E-04 ! cellular response to hormone stimulus GO:0032870 182 85 5,000 1,528E-05 5,926E-04 ! negative regulation of DNA replication GO:0008156 45 25 3,000 1,631E-05 6,227E-04 ! histone modification GO:0016570 104 52 4,000 1,78E-05 6,691E-04 ! morphogenesis of a branching structure GO:0001763 116 52 4,000 1,78E-05 6,589E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 1,912E-05 6,97E-04 ! positive regulation of growth GO:0045927 96 53 4,000 1,956E-05 7,026E-04 ! regulation of leukocyte proliferation GO:0070663 97 53 4,000 1,956E-05 6,924E-04 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! tube morphogenesis GO:0035239 194 89 5,000 1,989E-05 6,942E-04 ! epithelial tube morphogenesis GO:0060562 114 54 4,000 2,144E-05 7,379E-04 ! mitochondrial membrane organization GO:0007006 60 27 3,000 2,241E-05 7,605E-04 ! negative regulation of lymphocyte activation GO:0051250 55 27 3,000 2,241E-05 7,5E-04 ! negative regulation of cell motion GO:0051271 142 55 4,000 2,347E-05 7,749E-04 ! positive regulation of MAP kinase activity GO:0043406 174 93 5,000 2,556E-05 8,326E-04 ! regulation of DNA replication GO:0006275 105 56 4,000 2,564E-05 8,243E-04 ! regulation of fibroblast proliferation GO:0048145 56 28 3,000 2,602E-05 8,256E-04 ! protein amino acid acylation GO:0043543 59 28 3,000 2,602E-05 8,15E-04 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 2,718E-05 8,406E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 2,000 2,718E-05 8,301E-04 ! regulation of intracellular transport GO:0032386 108 57 4,000 2,797E-05 8,435E-04 ! aging GO:0007568 112 58 4,000 3,045E-05 9,073E-04 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 3,246E-05 9,555E-04 ! regulation of protein localization GO:0032880 188 97 5,000 3,246E-05 9,441E-04 ! positive regulation of multicellular organism growth GO:0040018 55 30 3,000 3,449E-05 9,913E-04 ! regulation of B cell activation GO:0050864 55 30 3,000 3,449E-05 9,798E-04 ! DNA catabolic process GO:0006308 94 60 4,000 3,594E-05 1,009E-03 ! oocyte development GO:0048599 20 11 2,000 3,721E-05 1,033E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 3,000 3,941E-05 1,082E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 3,000 3,941E-05 1,07E-03 ! metanephros development GO:0001656 81 32 3,000 4,482E-05 1,203E-03 ! hindbrain development GO:0030902 65 32 3,000 4,482E-05 1,19E-03 ! cranial nerve development GO:0021545 23 12 2,000 4,938E-05 1,297E-03 ! histone acetylation GO:0016573 27 12 2,000 4,938E-05 1,283E-03 ! peptidyl-lysine modification GO:0018205 21 12 2,000 4,938E-05 1,27E-03 ! T cell homeostasis GO:0043029 28 12 2,000 4,938E-05 1,257E-03 ! oocyte differentiation GO:0009994 21 12 2,000 4,938E-05 1,244E-03 ! response to ionizing radiation GO:0010212 74 33 3,000 5,076E-05 1,265E-03 ! negative regulation of cell growth GO:0030308 142 67 4,000 6,135E-05 1,514E-03 ! activation of MAPK activity GO:0000187 124 67 4,000 6,135E-05 1,499E-03 ! response to X-ray GO:0010165 28 13 2,000 6,39E-05 1,546E-03 ! digestive tract morphogenesis GO:0048546 31 13 2,000 6,39E-05 1,531E-03 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of DNA metabolic process GO:0051053 65 35 3,000 6,432E-05 1,526E-03 ! negative regulation of cell size GO:0045792 144 69 4,000 7,068E-05 1,66E-03 ! urogenital system development GO:0001655 149 69 4,000 7,068E-05 1,645E-03 ! androgen receptor signaling pathway GO:0030521 81 37 3,000 8,035E-05 1,852E-03 ! negative regulation of cell activation GO:0050866 69 37 3,000 8,035E-05 1,835E-03 ! actin filament organization GO:0007015 167 72 4,000 8,668E-05 1,961E-03 ! regulation of protein stability GO:0031647 77 38 3,000 8,937E-05 2,003E-03 ! regulation of caspase activity GO:0043281 136 74 4,000 9,88E-05 2,194E-03 ! carbohydrate homeostasis GO:0033500 59 39 3,000 9,91E-05 2,181E-03 GO:0042593|glucose homeostasis, ! lymphocyte homeostasis GO:0002260 33 15 2,000 1,007E-04 2,197E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 1,007E-04 2,178E-03 ! mammary gland development GO:0030879 93 40 3,000 1,096E-04 2,348E-03 ! cell-matrix adhesion GO:0007160 181 76 4,000 1,122E-04 2,383E-03 ! regulation of endopeptidase activity GO:0052548 141 77 4,000 1,194E-04 2,514E-03 ! gliogenesis GO:0042063 91 41 3,000 1,208E-04 2,523E-03 ! mesenchymal cell development GO:0014031 94 41 3,000 1,208E-04 2,502E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 1,234E-04 2,534E-03 ! T cell differentiation GO:0030217 93 42 3,000 1,329E-04 2,706E-03 ! cytokinesis GO:0000910 84 42 3,000 1,329E-04 2,684E-03 ! regulation of T cell proliferation GO:0042129 80 43 3,000 1,458E-04 2,92E-03 ! regulation of survival gene product expression GO:0045884 38 17 2,000 1,492E-04 2,963E-03 ! response to hypoxia GO:0001666 178 81 4,000 1,517E-04 2,989E-03 ! regulation of peptidase activity GO:0052547 150 82 4,000 1,608E-04 3,142E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 1,608E-04 3,117E-03 ! response to oxygen levels GO:0070482 183 83 4,000 1,702E-04 3,275E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 1,744E-04 3,328E-03 ! regulation of viral genome replication GO:0045069 30 18 2,000 1,782E-04 3,375E-03 ! epidermis morphogenesis GO:0048730 43 18 2,000 1,782E-04 3,349E-03 ! nerve development GO:0021675 34 18 2,000 1,782E-04 3,323E-03 ! defense response to virus GO:0051607 43 18 2,000 1,782E-04 3,298E-03 ! regulation of gene-specific transcription GO:0032583 102 46 3,000 1,901E-04 3,491E-03 ! positive regulation of protein transport GO:0051222 80 46 3,000 1,901E-04 3,465E-03 ! negative regulation of growth GO:0045926 168 85 4,000 1,904E-04 3,446E-03 ! regulation of JNK cascade GO:0046328 104 47 3,000 2,067E-04 3,714E-03 ! G1 phase of mitotic cell cycle GO:0000080 39 19 2,000 2,106E-04 3,756E-03 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 2,000 2,106E-04 3,729E-03 ! regulation of protein transport GO:0051223 165 87 4,000 2,124E-04 3,732E-03 GO:0070201|regulation of establishment of protein localization, ! positive regulation of cell cycle GO:0045787 96 48 3,000 2,245E-04 3,917E-03 ! mitochondrial transport GO:0006839 94 48 3,000 2,245E-04 3,889E-03 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 3,000 2,245E-04 3,861E-03 ! protein amino acid acetylation GO:0006473 41 20 2,000 2,467E-04 4,214E-03 ! response to alkaloid GO:0043279 38 20 2,000 2,467E-04 4,185E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 2,467E-04 4,156E-03 ! activation of caspase activity GO:0006919 95 50 3,000 2,631E-04 4,402E-03 ! regulation of gene expression, epigenetic GO:0040029 116 50 3,000 2,631E-04 4,372E-03 ! regulation of cell adhesion GO:0030155 241 92 4,000 2,757E-04 4,55E-03 ! negative regulation of immune system process GO:0002683 101 51 3,000 2,841E-04 4,658E-03 ! regulation of membrane potential GO:0042391 179 94 4,000 3,046E-04 4,961E-03 ! chromatin remodeling GO:0006338 122 53 3,000 3,297E-04 5,334E-03 ! hindlimb morphogenesis GO:0035137 47 22 2,000 3,302E-04 5,307E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 2,000 3,302E-04 5,273E-03 ! cellular response to starvation GO:0009267 37 22 2,000 3,302E-04 5,239E-03 ! G1 phase GO:0051318 44 22 2,000 3,302E-04 5,205E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 3,302E-04 5,171E-03 ! activation of JUN kinase activity GO:0007257 47 22 2,000 3,302E-04 5,138E-03 ! gut development GO:0048565 44 22 2,000 3,302E-04 5,106E-03 ! forebrain development GO:0030900 210 98 4,000 3,694E-04 5,676E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 3,767E-04 5,752E-03 GO:0045844|positive regulation of striated muscle development, ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 3,767E-04 5,716E-03 ! hypothalamus development GO:0021854 9 5 1,000 3,767E-04 5,681E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 3,767E-04 5,646E-03 ! glial cell fate commitment GO:0021781 14 5 1,000 3,767E-04 5,612E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 3,767E-04 5,578E-03 ! anagen GO:0042640 7 5 1,000 3,767E-04 5,544E-03 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 3,767E-04 5,511E-03 ! microvillus organization GO:0032528 8 5 1,000 3,767E-04 5,478E-03 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 1,000 3,767E-04 5,446E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 3,767E-04 5,414E-03 ! positive regulation of transporter activity GO:0032411 8 5 1,000 3,767E-04 5,382E-03 GO:0032414|positive regulation of ion transmembrane transporter activity, ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 3,767E-04 5,351E-03 ! cellular glucose homeostasis GO:0001678 6 5 1,000 3,767E-04 5,32E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 3,767E-04 5,289E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 3,767E-04 5,259E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 3,767E-04 5,229E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 3,767E-04 5,199E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 3,767E-04 5,17E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 3,767E-04 5,141E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 3,767E-04 5,113E-03 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 3,767E-04 5,085E-03 GO:0048103|somatic stem cell division, ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 3,78E-04 5,074E-03 ! regulation of multicellular organism growth GO:0040014 90 55 3,000 3,803E-04 5,077E-03 ! positive regulation of cell adhesion GO:0045785 61 24 2,000 4,301E-04 5,71E-03 ! regulation of viral reproduction GO:0050792 41 24 2,000 4,301E-04 5,679E-03 ! negative regulation of phosphorylation GO:0042326 52 24 2,000 4,301E-04 5,649E-03 ! oogenesis GO:0048477 44 24 2,000 4,301E-04 5,618E-03 ! positive regulation of caspase activity GO:0043280 108 57 3,000 4,363E-04 5,669E-03 GO:0010952|positive regulation of peptidase activity, ! protein import into nucleus, translocation GO:0000060 51 25 2,000 4,865E-04 6,288E-03 ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 4,865E-04 6,255E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 4,865E-04 6,222E-03 ! leukocyte homeostasis GO:0001776 50 25 2,000 4,865E-04 6,19E-03 ! protein tetramerization GO:0051262 57 25 2,000 4,865E-04 6,158E-03 ! kidney development GO:0001822 133 60 3,000 5,308E-04 6,685E-03 ! myelination GO:0042552 50 26 2,000 5,474E-04 6,858E-03 ! molting cycle process GO:0022404 52 26 2,000 5,474E-04 6,823E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 5,474E-04 6,789E-03 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 2,000 5,474E-04 6,754E-03 GO:0045936|negative regulation of phosphate metabolic process, ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 5,474E-04 6,721E-03 ! blastocyst development GO:0001824 50 26 2,000 5,474E-04 6,687E-03 ! positive regulation of JUN kinase activity GO:0043507 59 26 2,000 5,474E-04 6,654E-03 ! forebrain regionalization GO:0021871 9 6 1,000 5,628E-04 6,806E-03 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 1,000 5,628E-04 6,773E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 5,628E-04 6,739E-03 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 1,000 5,628E-04 6,706E-03 ! protein lipoylation GO:0009249 10 6 1,000 5,628E-04 6,674E-03 ! regulation of retroviral genome replication GO:0045091 8 6 1,000 5,628E-04 6,642E-03 ! hyperosmotic response GO:0006972 10 6 1,000 5,628E-04 6,61E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 5,628E-04 6,578E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of spindle localization GO:0051293 16 6 1,000 5,628E-04 6,547E-03 GO:0051653|spindle localization, ! response to UV-C GO:0010225 14 6 1,000 5,628E-04 6,516E-03 ! astrocyte development GO:0014002 16 6 1,000 5,628E-04 6,485E-03 ! hair follicle maturation GO:0048820 8 6 1,000 5,628E-04 6,455E-03 ! Schwann cell development GO:0014044 15 6 1,000 5,628E-04 6,424E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 5,628E-04 6,395E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 5,628E-04 6,365E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 5,628E-04 6,336E-03 ! ectodermal gut morphogenesis GO:0048567 16 6 1,000 5,628E-04 6,307E-03 GO:0007439|ectodermal gut development, ! regulation of homeostatic process GO:0032844 148 62 3,000 6,014E-04 6,709E-03 ! response to starvation GO:0042594 47 27 2,000 6,131E-04 6,808E-03 ! response to toxin GO:0009636 49 27 2,000 6,131E-04 6,777E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 6,131E-04 6,746E-03 ! cellular response to nutrient levels GO:0031669 45 27 2,000 6,131E-04 6,716E-03 ! skeletal system morphogenesis GO:0048705 118 63 3,000 6,391E-04 6,97E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 6,784E-04 7,366E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 6,835E-04 7,389E-03 ! regulation of JUN kinase activity GO:0043506 67 28 2,000 6,835E-04 7,356E-03 ! positive regulation of cell motion GO:0051272 157 65 3,000 7,195E-04 7,709E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 7,589E-04 8,096E-03 ! response to organic cyclic substance GO:0014070 58 29 2,000 7,589E-04 8,061E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 7,622E-04 8,061E-03 ! positive regulation of protein ubiquitination GO:0031398 14 7 1,000 7,847E-04 8,263E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 7,847E-04 8,227E-03 ! prostate gland development GO:0030850 14 7 1,000 7,847E-04 8,192E-03 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 7,847E-04 8,157E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 7,847E-04 8,122E-03 ! protein-cofactor linkage GO:0018065 13 7 1,000 7,847E-04 8,088E-03 ! spinal cord patterning GO:0021511 14 7 1,000 7,847E-04 8,054E-03 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 1,000 7,847E-04 8,021E-03 ! induction of apoptosis by oxidative stress GO:0008631 9 7 1,000 7,847E-04 7,987E-03 ! organ growth GO:0035265 15 7 1,000 7,847E-04 7,954E-03 ! male sex determination GO:0030238 15 7 1,000 7,847E-04 7,921E-03 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 7,847E-04 7,888E-03 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 7,847E-04 7,856E-03 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 1,000 7,847E-04 7,824E-03 ! centrosome duplication GO:0051298 14 7 1,000 7,847E-04 7,792E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 7,847E-04 7,761E-03 ! peptidyl-threonine modification GO:0018210 26 7 1,000 7,847E-04 7,729E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 7,847E-04 7,698E-03 ! embryonic limb morphogenesis GO:0030326 139 67 3,000 8,067E-04 7,883E-03 GO:0035113|embryonic appendage morphogenesis, ! tissue homeostasis GO:0001894 50 30 2,000 8,394E-04 8,17E-03 GO:0048871|multicellular organismal homeostasis, ! regulation of cellular response to stress GO:0080135 142 68 3,000 8,53E-04 8,269E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 9,011E-04 8,701E-03 ! lung development GO:0030324 165 69 3,000 9,011E-04 8,667E-03 ! developmental maturation GO:0021700 128 69 3,000 9,011E-04 8,633E-03 ! ensheathment of neurons GO:0007272 64 31 2,000 9,251E-04 8,828E-03 GO:0008366|axon ensheathment, ! negative regulation of kinase activity GO:0033673 145 70 3,000 9,511E-04 9,041E-03 ! cell cycle checkpoint GO:0000075 145 71 3,000 1,003E-03 9,498E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,003E-03 9,462E-03 ! spindle organization GO:0007051 50 32 2,000 1,016E-03 9,548E-03 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 1,016E-03 9,512E-03 ! peripheral nervous system development GO:0007422 68 32 2,000 1,016E-03 9,475E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,016E-03 9,439E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,042E-03 9,642E-03 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 1,042E-03 9,605E-03 ! prostaglandin biosynthetic process GO:0001516 15 8 1,000 1,042E-03 9,569E-03 GO:0046457|prostanoid biosynthetic process, ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,042E-03 9,534E-03 ! melanin metabolic process GO:0006582 17 8 1,000 1,042E-03 9,498E-03 ! Schwann cell differentiation GO:0014037 21 8 1,000 1,042E-03 9,463E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 1,042E-03 9,428E-03 ! succinate metabolic process GO:0006105 17 8 1,000 1,042E-03 9,393E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,042E-03 9,358E-03 ! pigment granule organization GO:0048753 17 8 1,000 1,042E-03 9,324E-03 ! astrocyte differentiation GO:0048708 19 8 1,000 1,042E-03 9,29E-03 ! regulation of pigmentation during development GO:0048070 25 8 1,000 1,042E-03 9,256E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,042E-03 9,223E-03 ! response to UV-B GO:0010224 17 8 1,000 1,042E-03 9,189E-03 ! DNA topological change GO:0006265 12 8 1,000 1,042E-03 9,156E-03 ! response to tumor cell GO:0002347 16 8 1,000 1,042E-03 9,123E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 1,042E-03 9,091E-03 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 1,000 1,042E-03 9,059E-03 ! negative regulation of DNA replication initiation GO:0032297 10 8 1,000 1,042E-03 9,026E-03 GO:0000076|DNA replication checkpoint, ! appendage morphogenesis GO:0035107 150 72 3,000 1,057E-03 9,125E-03 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 3,000 1,057E-03 9,092E-03 ! regulation of MAPKKK cascade GO:0043408 157 72 3,000 1,057E-03 9,061E-03 ! appendage development GO:0048736 151 73 3,000 1,113E-03 9,506E-03 GO:0060173|limb development, ! negative regulation of transferase activity GO:0051348 155 74 3,000 1,171E-03 9,967E-03 ! respiratory system development GO:0060541 175 74 3,000 1,171E-03 9,932E-03 ! glial cell differentiation GO:0010001 67 34 2,000 1,215E-03 0,01026959 ! reproductive structure development GO:0048608 131 75 3,000 1,231E-03 0,01036916 ! lymphocyte differentiation GO:0030098 193 76 3,000 1,293E-03 0,01085529 ! regulation of striated muscle tissue development GO:0016202 81 35 2,000 1,323E-03 0,01106652 ! telencephalon development GO:0021537 81 35 2,000 1,323E-03 0,01102875 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,334E-03 0,01108631 ! cell proliferation in forebrain GO:0021846 18 9 1,000 1,334E-03 0,01104873 ! regulation of activated T cell proliferation GO:0046006 19 9 1,000 1,334E-03 0,0110114 ! regulation of glycolysis GO:0006110 20 9 1,000 1,334E-03 0,01097433 ! cerebral cortex cell migration GO:0021795 18 9 1,000 1,334E-03 0,0109375 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,334E-03 0,01090092 ! protein targeting to ER GO:0045047 25 9 1,000 1,334E-03 0,01086458 ! T cell selection GO:0045058 27 9 1,000 1,334E-03 0,01082849 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,334E-03 0,01079263 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 1,000 1,334E-03 0,01075701 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,334E-03 0,01072163 ! regulation of catabolic process GO:0009894 173 77 3,000 1,357E-03 0,01087213 ! regulation of muscle development GO:0048634 82 36 2,000 1,436E-03 0,01146796 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 3,000 1,493E-03 0,01187764 ! protein oligomerization GO:0051259 149 79 3,000 1,493E-03 0,01183908 ! female gonad development GO:0008585 71 37 2,000 1,556E-03 0,01230262 ! meiosis GO:0007126 143 81 3,000 1,637E-03 0,01290045 GO:0051327|M phase of meiotic cell cycle, ! regulation of developmental growth GO:0048638 16 10 1,000 1,661E-03 0,013047 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,661E-03 0,01300518 ! COPI coating of Golgi vesicle GO:0048205 23 10 1,000 1,661E-03 0,01296363 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 1,000 1,661E-03 0,01292235 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 1,661E-03 0,01288132 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 1,661E-03 0,01284056 ! phosphagen metabolic process GO:0006599 17 10 1,000 1,661E-03 0,01280005 GO:0006600|creatine metabolic process, ! B cell proliferation GO:0042100 19 10 1,000 1,661E-03 0,0127598 ! multicellular organism growth GO:0035264 19 10 1,000 1,661E-03 0,0127198 ! epithelial cell development GO:0002064 21 10 1,000 1,661E-03 0,01268005 ! motor axon guidance GO:0008045 22 10 1,000 1,661E-03 0,01264055 ! protein heterooligomerization GO:0051291 17 10 1,000 1,661E-03 0,01260129 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,661E-03 0,01256228 ! DNA ligation GO:0006266 18 10 1,000 1,661E-03 0,01252351 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 1,661E-03 0,01248498 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 1,661E-03 0,01244668 ! positive regulation of viral reproduction GO:0048524 19 10 1,000 1,661E-03 0,01240861 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,661E-03 0,01237078 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 1,661E-03 0,01233318 ! embryonic skeletal system morphogenesis GO:0048704 68 38 2,000 1,682E-03 0,01245042 ! DNA integrity checkpoint GO:0031570 82 38 2,000 1,682E-03 0,01241281 ! meiotic cell cycle GO:0051321 144 82 3,000 1,713E-03 0,01260265 ! response to drug GO:0042493 149 83 3,000 1,791E-03 0,01313776 ! T cell activation GO:0042110 189 84 3,000 1,871E-03 0,01368747 ! regulation of ligase activity GO:0051340 147 84 3,000 1,871E-03 0,01364662 ! development of primary female sexual characteristics GO:0046545 80 40 2,000 1,952E-03 0,01419168 GO:0046660|female sex differentiation, ! regulation of action potential in neuron GO:0019228 80 40 2,000 1,952E-03 0,01414957 ! negative regulation of muscle development GO:0048635 27 11 1,000 2,022E-03 0,01461275 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 1,000 2,022E-03 0,01456965 ! neuron fate specification GO:0048665 18 11 1,000 2,022E-03 0,0145268 ! telencephalon cell migration GO:0022029 23 11 1,000 2,022E-03 0,0144842 ! Golgi vesicle budding GO:0048194 26 11 1,000 2,022E-03 0,01444184 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,022E-03 0,01439974 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 2,022E-03 0,01435788 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of intracellular pH GO:0051453 21 11 1,000 2,022E-03 0,01431626 ! behavioral fear response GO:0001662 27 11 1,000 2,022E-03 0,01427489 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 2,022E-03 0,01423375 ! alpha-beta T cell activation GO:0046631 26 11 1,000 2,022E-03 0,01419285 ! nitric oxide metabolic process GO:0046209 17 11 1,000 2,022E-03 0,01415218 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 1,000 2,022E-03 0,01411175 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 25 11 1,000 2,022E-03 0,01407154 ! thymus development GO:0048538 29 11 1,000 2,022E-03 0,01403156 ! embryonic gut development GO:0048566 19 11 1,000 2,022E-03 0,01399182 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 1,000 2,022E-03 0,01395229 ! regulation of embryonic development GO:0045995 35 11 1,000 2,022E-03 0,01391299 ! regulation of T cell differentiation GO:0045580 78 42 2,000 2,247E-03 0,01542286 ! dorsal/ventral pattern formation GO:0009953 75 42 2,000 2,247E-03 0,01537966 ! response to xenobiotic stimulus GO:0009410 63 42 2,000 2,247E-03 0,0153367 ! neuron migration GO:0001764 85 43 2,000 2,405E-03 0,01636659 ! positive regulation of protein modification process GO:0031401 156 90 3,000 2,408E-03 0,01633972 ! regulation of cell cycle process GO:0010564 161 90 3,000 2,408E-03 0,01629445 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 2,416E-03 0,01630609 ! virus-host interaction GO:0019048 30 12 1,000 2,416E-03 0,01626117 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 2,416E-03 0,0162165 ! ventral spinal cord development GO:0021517 25 12 1,000 2,416E-03 0,01617207 ! mitotic spindle organization GO:0007052 23 12 1,000 2,416E-03 0,01612788 ! forebrain cell migration GO:0021885 24 12 1,000 2,416E-03 0,01608394 ! autonomic nervous system development GO:0048483 24 12 1,000 2,416E-03 0,01604023 ! response to reactive oxygen species GO:0000302 75 44 2,000 2,569E-03 0,01701082 ! double-strand break repair GO:0006302 85 44 2,000 2,569E-03 0,01696484 ! keratinocyte differentiation GO:0030216 81 45 2,000 2,74E-03 0,0180456 ! biopolymer methylation GO:0043414 91 45 2,000 2,74E-03 0,01799709 ! B cell differentiation GO:0030183 124 45 2,000 2,74E-03 0,01794884 ! female gamete generation GO:0007292 71 45 2,000 2,74E-03 0,01790085 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 2,844E-03 0,01852709 GO:0000725|recombinational repair, ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,844E-03 0,01847781 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 2,844E-03 0,0184288 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 2,844E-03 0,01838005 ! histone methylation GO:0016571 29 13 1,000 2,844E-03 0,01833155 ! chromatin silencing GO:0006342 29 13 1,000 2,844E-03 0,01828331 ! gland morphogenesis GO:0022612 31 13 1,000 2,844E-03 0,01823532 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 2,844E-03 0,01818759 ! spleen development GO:0048536 24 13 1,000 2,844E-03 0,0181401 ! insulin secretion GO:0030073 24 13 1,000 2,844E-03 0,01809286 ! pigmentation GO:0043473 103 46 2,000 2,918E-03 0,01851847 ! negative regulation of cell migration GO:0030336 122 46 2,000 2,918E-03 0,01847049 ! regulation of T cell activation GO:0050863 175 96 3,000 3,042E-03 0,0192009 ! neural tube development GO:0021915 91 47 2,000 3,103E-03 0,01953939 ! leukocyte differentiation GO:0002521 232 98 3,000 3,276E-03 0,02057366 ! methylation GO:0032259 97 48 2,000 3,295E-03 0,0206414 ! regulation of S phase GO:0033261 26 14 1,000 3,304E-03 0,02064613 ! hair follicle morphogenesis GO:0031069 27 14 1,000 3,304E-03 0,02059346 ! fear response GO:0042596 34 14 1,000 3,304E-03 0,02054106 ! cotranslational protein targeting to membrane GO:0006613 26 14 1,000 3,304E-03 0,02048893 ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 1,000 3,304E-03 0,02043706 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 3,304E-03 0,02038545 ! regulation of cellular pH GO:0030641 27 14 1,000 3,304E-03 0,0203341 ! regulation of lymphocyte differentiation GO:0045619 92 49 2,000 3,494E-03 0,02144825 ! JNK cascade GO:0007254 106 49 2,000 3,494E-03 0,0213945 ! regulation of action potential GO:0001508 102 50 2,000 3,7E-03 0,02260064 ! regulation of ossification GO:0030278 123 50 2,000 3,7E-03 0,02254428 ! epidermal cell differentiation GO:0009913 87 50 2,000 3,7E-03 0,0224882 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 3,797E-03 0,02301915 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3,797E-03 0,02296218 ! sulfate transport GO:0008272 27 15 1,000 3,797E-03 0,02290548 ! regulation of mRNA processing GO:0050684 26 15 1,000 3,797E-03 0,02284906 ! vesicle coating GO:0006901 38 15 1,000 3,797E-03 0,02279292 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 3,797E-03 0,02273706 ! G1/S transition checkpoint GO:0031575 37 15 1,000 3,797E-03 0,02268147 ! histone deacetylation GO:0016575 24 15 1,000 3,797E-03 0,02262614 ! synaptic transmission, cholinergic GO:0007271 24 15 1,000 3,797E-03 0,02257109 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 2,000 3,914E-03 0,02320847 ! response to estrogen stimulus GO:0043627 98 52 2,000 4,135E-03 0,02445883 ! regulation of protein ubiquitination GO:0031396 28 16 1,000 4,322E-03 0,02550457 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 4,322E-03 0,02544311 ! embryonic hindlimb morphogenesis GO:0035116 36 16 1,000 4,322E-03 0,02538195 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 4,322E-03 0,02532108 ! heterophilic cell adhesion GO:0007157 43 16 1,000 4,322E-03 0,02526051 ! regulation of transmembrane transporter activity GO:0022898 27 16 1,000 4,322E-03 0,02520022 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! protein polyubiquitination GO:0000209 41 16 1,000 4,322E-03 0,02514022 ! pituitary gland development GO:0021983 30 16 1,000 4,322E-03 0,0250805 ! response to osmotic stress GO:0006970 27 16 1,000 4,322E-03 0,02502107 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 4,322E-03 0,02496192 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 4,322E-03 0,02490305 ! vesicle organization GO:0016050 127 53 2,000 4,363E-03 0,02508061 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 4,363E-03 0,02502173 ! embryonic skeletal system development GO:0048706 101 54 2,000 4,599E-03 0,02631229 ! cell maturation GO:0048469 107 55 2,000 4,842E-03 0,02764004 ! metencephalon development GO:0022037 32 17 1,000 4,878E-03 0,02778124 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 4,878E-03 0,02771663 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 4,878E-03 0,02765232 ! glial cell development GO:0021782 28 17 1,000 4,878E-03 0,02758831 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 1,000 4,878E-03 0,0275246 ! induction of apoptosis via death domain receptors GO:0008625 23 17 1,000 4,878E-03 0,02746118 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 4,878E-03 0,02739805 GO:0031114|regulation of microtubule depolymerization, ! membrane budding GO:0006900 42 17 1,000 4,878E-03 0,02733521 ! regulation of protein binding GO:0043393 33 17 1,000 4,878E-03 0,02727266 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 4,878E-03 0,02721039 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 4,878E-03 0,02714841 ! regulation of protein catabolic process GO:0042176 126 56 2,000 5,093E-03 0,02827998 ! regulation of bone remodeling GO:0046850 143 57 2,000 5,352E-03 0,02964913 ! nucleotide-excision repair GO:0006289 91 57 2,000 5,352E-03 0,02958205 ! limbic system development GO:0021761 40 18 1,000 5,466E-03 0,03014334 ! centrosome cycle GO:0007098 26 18 1,000 5,466E-03 0,03007545 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 5,466E-03 0,03000787 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 5,466E-03 0,02994059 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 5,466E-03 0,0298736 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 5,466E-03 0,02980692 ! positive regulation of cell migration GO:0030335 137 58 2,000 5,619E-03 0,03057088 ! regulation of tissue remodeling GO:0034103 146 58 2,000 5,619E-03 0,03050294 ! establishment of organelle localization GO:0051656 122 59 2,000 5,893E-03 0,0319213 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 6,084E-03 0,03288486 ! memory GO:0007613 34 19 1,000 6,084E-03 0,03281227 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 6,084E-03 0,03274 ! cerebral cortex development GO:0021987 40 19 1,000 6,084E-03 0,03266804 ! neuromuscular junction development GO:0007528 43 19 1,000 6,084E-03 0,0325964 ! peptide cross-linking GO:0018149 39 19 1,000 6,084E-03 0,03252507 ! cellular pigmentation GO:0033059 37 19 1,000 6,084E-03 0,03245406 ! proximal/distal pattern formation GO:0009954 33 19 1,000 6,084E-03 0,03238335 ! embryonic organ morphogenesis GO:0048562 34 19 1,000 6,084E-03 0,03231295 ! peptide hormone secretion GO:0030072 32 19 1,000 6,084E-03 0,03224286 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 6,733E-03 0,03560291 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 1,000 6,733E-03 0,03552602 ! protein amino acid deacetylation GO:0006476 34 20 1,000 6,733E-03 0,03544945 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 6,733E-03 0,03537322 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 6,733E-03 0,03529731 ! peptide secretion GO:0002790 38 20 1,000 6,733E-03 0,03522172 ! negative regulation of translation GO:0017148 32 20 1,000 6,733E-03 0,03514646 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 6,764E-03 0,03523082 ! integrin-mediated signaling pathway GO:0007229 160 64 2,000 7,384E-03 0,03838138 ! hormone secretion GO:0046879 39 21 1,000 7,412E-03 0,03844224 ! lipid phosphorylation GO:0046834 43 21 1,000 7,412E-03 0,0383608 ! ovarian follicle development GO:0001541 39 21 1,000 7,412E-03 0,0382797 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 7,412E-03 0,03819894 ! prostaglandin metabolic process GO:0006693 43 21 1,000 7,412E-03 0,03811852 GO:0006692|prostanoid metabolic process, ! diencephalon development GO:0021536 36 21 1,000 7,412E-03 0,03803844 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 7,412E-03 0,03795869 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 7,412E-03 0,03787928 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 7,412E-03 0,0378002 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 2,000 7,707E-03 0,03922306 ! ear development GO:0043583 114 66 2,000 8,037E-03 0,04082106 ! gonad development GO:0008406 115 66 2,000 8,037E-03 0,04073637 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 8,12E-03 0,04106885 ! renal system process GO:0003014 42 22 1,000 8,12E-03 0,04098399 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 8,12E-03 0,04089949 ! positive regulation of B cell activation GO:0050871 42 22 1,000 8,12E-03 0,04081533 ! response to cytokine stimulus GO:0034097 69 22 1,000 8,12E-03 0,04073152 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 8,12E-03 0,04064806 ! protein stabilization GO:0050821 41 22 1,000 8,12E-03 0,04056493 ! chromosome segregation GO:0007059 127 67 2,000 8,376E-03 0,0417611 ! negative regulation of ligase activity GO:0051352 116 68 2,000 8,723E-03 0,04340367 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 2,000 8,723E-03 0,04331545 ! positive regulation of DNA replication GO:0045740 44 23 1,000 8,857E-03 0,04388938 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 8,857E-03 0,04380054 ! regeneration GO:0031099 42 23 1,000 8,857E-03 0,04371205 ! response to ethanol GO:0045471 47 23 1,000 8,857E-03 0,04362392 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 8,857E-03 0,04353615 ! vesicle targeting GO:0006903 49 23 1,000 8,857E-03 0,04344873 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 8,857E-03 0,04336165 ! DNA modification GO:0006304 36 23 1,000 8,857E-03 0,04327493 ! hormone transport GO:0009914 41 23 1,000 8,857E-03 0,04318855 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 2,000 9,079E-03 0,04418293 ! homeostasis of number of cells GO:0048872 131 69 2,000 9,079E-03 0,04409509 ! germ cell development GO:0007281 133 70 2,000 9,443E-03 0,04577165 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 9,623E-03 0,04655246 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 9,623E-03 0,04646046 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 9,623E-03 0,04636883 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 9,623E-03 0,04627755 ! sex determination GO:0007530 48 24 1,000 9,623E-03 0,04618663 ! pallium development GO:0021543 56 24 1,000 9,623E-03 0,04609607 ! negative regulation of catabolic process GO:0009895 52 24 1,000 9,623E-03 0,04600586 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 9,623E-03 0,045916 ! B cell activation GO:0042113 179 72 2,000 0,010196 0,0485552 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 2,000 0,010196 0,04846073 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 2,000 0,010196 0,04836664 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 0,01041748 0,04932153 ! regulation of transmembrane transport GO:0034762 39 25 1,000 0,01041748 0,04922613 ! leukocyte adhesion GO:0007159 55 25 1,000 0,01041748 0,0491311 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 0,01041748 0,04903643 ! chromosome condensation GO:0030261 48 25 1,000 0,01041748 0,04894213 ! interaction with host GO:0051701 66 25 1,000 0,01041748 0,04884819 ! lymphocyte proliferation GO:0046651 55 25 1,000 0,01041748 0,04875461 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 0,01098306 0,05130329 ! organelle localization GO:0051640 155 74 2,000 0,01098306 0,05120539 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 0,01123999 0,0523034 ! protein amino acid alkylation GO:0008213 59 26 1,000 0,01123999 0,05220396 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 0,01123999 0,05210491 ! microtubule organizing center organization GO:0031023 42 26 1,000 0,01123999 0,05200622 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 1,000 0,01123999 0,05190791 ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,01123999 0,05180997 ! negative regulation of cell development GO:0010721 83 26 1,000 0,01123999 0,0517124 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,01123999 0,0516152 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 0,01123999 0,05151836 ! neural tube closure GO:0001843 58 26 1,000 0,01123999 0,05142188 GO:0060606|tube closure, ! regulation of transcription factor activity GO:0051090 137 75 2,000 0,0113894 0,05200806 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,0113894 0,05191103 ! learning or memory GO:0007611 161 76 2,000 0,01180432 0,05370197 ! tube lumen formation GO:0035148 59 27 1,000 0,01209014 0,05490002 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 0,01209014 0,05479817 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01209014 0,05469669 ! leukocyte proliferation GO:0070661 59 27 1,000 0,01209014 0,05459558 GO:0032943|mononuclear cell proliferation, ! positive regulation of ligase activity GO:0051351 130 77 2,000 0,01222785 0,05511556 ! neuron fate commitment GO:0048663 52 28 1,000 0,01296757 0,05834214 ! base-excision repair GO:0006284 41 28 1,000 0,01296757 0,05823489 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 0,01310083 0,05872536 ! development of primary sexual characteristics GO:0045137 143 80 2,000 0,01355033 0,06062903 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01355033 0,06051819 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01387192 0,06184142 ! primary neural tube formation GO:0014020 61 29 1,000 0,01387192 0,06172877 ! somitogenesis GO:0001756 52 29 1,000 0,01387192 0,06161654 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01387192 0,06150471 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 0,01400853 0,06199791 ! protein import into nucleus GO:0006606 174 82 2,000 0,01447546 0,06394857 ! icosanoid biosynthetic process GO:0046456 60 30 1,000 0,01480281 0,06527666 ! acute-phase response GO:0006953 50 30 1,000 0,01480281 0,06515905 ! cell fate determination GO:0001709 64 30 1,000 0,01480281 0,06504185 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,01480281 0,06492508 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 0,01495114 0,06545813 GO:0045937|positive regulation of phosphate metabolic process, ! nuclear import GO:0051170 177 83 2,000 0,01495114 0,06534103 ! response to nutrient GO:0007584 135 84 2,000 0,01543558 0,06733771 ! ovulation cycle process GO:0022602 55 31 1,000 0,01575989 0,06862999 ! peptide transport GO:0015833 60 31 1,000 0,01575989 0,06850787 ! male gonad development GO:0008584 56 31 1,000 0,01575989 0,06838619 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01575989 0,06826493 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,01575989 0,06814411 ! eye morphogenesis GO:0048592 65 31 1,000 0,01575989 0,06802372 ! response to heat GO:0009408 54 31 1,000 0,01575989 0,06790374 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,0159288 0,06851065 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,01674281 0,07188521 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,01674281 0,07175909 ! ovulation cycle GO:0042698 57 32 1,000 0,01674281 0,07163342 ! BMP signaling pathway GO:0030509 71 32 1,000 0,01674281 0,07150819 ! gene silencing GO:0016458 71 32 1,000 0,01674281 0,07138339 ! one-carbon metabolic process GO:0006730 167 88 2,000 0,01746126 0,07431683 ! regulation of pH GO:0006885 56 33 1,000 0,0177512 0,07541945 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,0177512 0,07528852 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 1,000 0,0177512 0,07515804 ! regulation of axonogenesis GO:0050770 86 33 1,000 0,0177512 0,075028 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,0177512 0,07489842 ! establishment of vesicle localization GO:0051650 67 33 1,000 0,0177512 0,07476929 ! regulation of DNA binding GO:0051101 167 89 2,000 0,01798973 0,07564356 ! protein localization in nucleus GO:0034504 192 89 2,000 0,01798973 0,07551358 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01878472 0,0787154 ! post-embryonic development GO:0009791 76 34 1,000 0,01878472 0,07858061 ! cell fate specification GO:0001708 56 34 1,000 0,01878472 0,07844629 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01878472 0,07831242 ! DNA damage checkpoint GO:0000077 78 35 1,000 0,01984303 0,0825835 ! positive regulation of endocytosis GO:0045807 56 35 1,000 0,01984303 0,08244305 ! vesicle localization GO:0051648 70 35 1,000 0,01984303 0,08230308 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 0,02019207 0,08360887 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 2,000 0,02019207 0,0834674 GO:0010498|proteasomal protein catabolic process, ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,02092577 0,08635414 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,02092577 0,08620851 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,02092577 0,08606338 ! positive regulation of cell development GO:0010720 85 36 1,000 0,02092577 0,08591874 ! protein targeting to membrane GO:0006612 75 36 1,000 0,02092577 0,08577458 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,02092577 0,0856309 ! embryonic organ development GO:0048568 67 36 1,000 0,02092577 0,08548771 ! sex differentiation GO:0007548 171 96 2,000 0,02193689 0,08946882 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,02203261 0,08970943 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,02203261 0,08956016 ! xenobiotic metabolic process GO:0006805 55 37 1,000 0,02203261 0,08941139 ! sister chromatid segregation GO:0000819 65 37 1,000 0,02203261 0,08926311 ! odontogenesis GO:0042476 74 37 1,000 0,02203261 0,08911533 ! actomyosin structure organization GO:0031032 68 37 1,000 0,02203261 0,08896803 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,02203261 0,08882122 ! transcription initiation GO:0006352 171 97 2,000 0,02253624 0,09070187 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,02316321 0,0930719 ! meiosis I GO:0007127 74 38 1,000 0,02316321 0,09291907 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,02316321 0,09276674 ! glycogen metabolic process GO:0005977 63 38 1,000 0,02316321 0,09261491 ! pigment metabolic process GO:0042440 87 38 1,000 0,02316321 0,09246358 ! neural tube formation GO:0001841 79 38 1,000 0,02316321 0,09231275 ! regulation of neuron projection development GO:0010975 102 39 1,000 0,02431723 0,09675408 ! negative regulation of binding GO:0051100 71 39 1,000 0,02431723 0,09659675 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,02431723 0,09643994 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,02431723 0,09628363 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,02431723 0,09612784 ! glucan metabolic process GO:0044042 64 39 1,000 0,02431723 0,09597254 GO:0006073|cellular glucan metabolic process, ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,02438751 0,09609464 GO:0060538|skeletal muscle organ development, ! establishment or maintenance of cell polarity GO:0007163 96 41 1,000 0,02669425 0,10501459 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,02669425 0,10484576 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,02669425 0,10467746 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,02669425 0,10450971 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,02669425 0,1043425 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,02791659 0,10894606 ! ear morphogenesis GO:0042471 64 42 1,000 0,02791659 0,10877231 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02916106 0,11344023 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,02916106 0,11325988 ! glucose transport GO:0015758 66 43 1,000 0,02916106 0,1130801 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,02916106 0,11290089 ! segmentation GO:0035282 78 43 1,000 0,02916106 0,11272225 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,02916106 0,11254417 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,03042733 0,11724599 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,03042733 0,11706136 ! hexose transport GO:0008645 68 44 1,000 0,03042733 0,1168773 GO:0015749|monosaccharide transport, ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,03056852 0,11723531 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,03056852 0,11705156 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03056852 0,11686838 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,03056852 0,11668577 ! neuron fate determination GO:0048664 7 5 0,000 0,03056852 0,11650374 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03056852 0,11632227 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03056852 0,11614136 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,03056852 0,11596102 ! polyol transport GO:0015791 12 5 0,000 0,03056852 0,11578123 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03056852 0,115602 ! response to superoxide GO:0000303 10 5 0,000 0,03056852 0,11542333 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03056852 0,11524521 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03056852 0,11506763 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,03056852 0,11489061 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03056852 0,11471412 ! female meiosis GO:0007143 10 5 0,000 0,03056852 0,11453818 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03056852 0,11436278 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03056852 0,11418791 ! cobalt ion transport GO:0006824 11 5 0,000 0,03056852 0,11401358 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03056852 0,11383978 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03056852 0,11366651 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03056852 0,11349376 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,03056852 0,11332154 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03056852 0,11314984 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03056852 0,11297866 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03056852 0,112808 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03056852 0,11263785 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,03056852 0,11246821 ! transposition GO:0032196 9 5 0,000 0,03056852 0,11229909 ! negative chemotaxis GO:0050919 16 5 0,000 0,03056852 0,11213047 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03056852 0,11196236 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03056852 0,11179475 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03056852 0,11162765 ! behavioral response to pain GO:0048266 10 5 0,000 0,03056852 0,11146104 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03056852 0,11129492 ! Notch receptor processing GO:0007220 11 5 0,000 0,03056852 0,11112931 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03056852 0,11096418 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03056852 0,11079955 ! micturition GO:0060073 9 5 0,000 0,03056852 0,1106354 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03056852 0,11047174 ! copulation GO:0007620 9 5 0,000 0,03056852 0,11030856 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03056852 0,11014586 ! bioluminescence GO:0008218 9 5 0,000 0,03056852 0,10998364 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03056852 0,1098219 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03056852 0,10966064 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03056852 0,10949985 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03056852 0,10933952 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03056852 0,10917967 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03056852 0,10902028 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03056852 0,10886136 ! grooming behavior GO:0007625 6 5 0,000 0,03056852 0,1087029 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03056852 0,1085449 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03056852 0,10838737 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03056852 0,10823028 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03056852 0,10807365 ! response to protozoan GO:0001562 13 5 0,000 0,03056852 0,10791748 ! lymph vessel development GO:0001945 10 5 0,000 0,03056852 0,10776175 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03056852 0,10760648 ! endochondral ossification GO:0001958 17 5 0,000 0,03056852 0,10745165 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03056852 0,10729726 ! single strand break repair GO:0000012 8 5 0,000 0,03056852 0,10714332 ! parathyroid gland development GO:0060017 14 5 0,000 0,03056852 0,10698982 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03056852 0,10683676 ! cytokine secretion GO:0050663 15 5 0,000 0,03056852 0,10668414 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03056852 0,10653195 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03056852 0,10638019 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,03056852 0,10622887 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,03056852 0,10607798 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03056852 0,10592751 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03056852 0,10577747 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,03056852 0,10562786 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03056852 0,10547866 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03056852 0,10532989 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03056852 0,10518154 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,03056852 0,10503361 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03056852 0,10488609 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03056852 0,10473898 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03056852 0,10459229 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03056852 0,10444601 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,03056852 0,10430013 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03056852 0,10415466 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03056852 0,1040096 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03056852 0,10386494 ! polyol catabolic process GO:0046174 9 5 0,000 0,03056852 0,10372069 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03056852 0,10357683 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03056852 0,10343337 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03056852 0,10329031 ! muscle cell migration GO:0014812 8 5 0,000 0,03056852 0,10314764 ! mitochondrial fission GO:0000266 8 5 0,000 0,03056852 0,10300537 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03056852 0,10286349 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,03056852 0,102722 ! mRNA transcription GO:0009299 10 5 0,000 0,03056852 0,1025809 ! nerve growth factor processing GO:0032455 9 5 0,000 0,03056852 0,10244018 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,03056852 0,10229986 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03056852 0,10215991 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03056852 0,10202035 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03056852 0,10188117 ! monocyte activation GO:0042117 10 5 0,000 0,03056852 0,10174236 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03056852 0,10160394 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03056852 0,10146589 ! response to food GO:0032094 6 5 0,000 0,03056852 0,10132822 ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03056852 0,10119091 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03056852 0,10105398 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,03056852 0,10091743 ! forebrain neuron development GO:0021884 13 5 0,000 0,03056852 0,10078123 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03056852 0,10064541 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,03056852 0,10050995 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,03056852 0,10037486 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03056852 0,10024013 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03056852 0,10010576 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03056852 0,09997175 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,03056852 0,09983809 ! lipid glycosylation GO:0030259 7 5 0,000 0,03056852 0,0997048 ! nucleobase transport GO:0015851 6 5 0,000 0,03056852 0,09957186 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03056852 0,09943927 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03056852 0,09930704 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,03056852 0,09917516 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03056852 0,09904363 ! basic amino acid transport GO:0015802 12 5 0,000 0,03056852 0,09891244 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03056852 0,09878161 ! actin nucleation GO:0045010 11 5 0,000 0,03056852 0,09865112 ! depurination GO:0045007 5 5 0,000 0,03056852 0,09852097 ! depyrimidination GO:0045008 10 5 0,000 0,03056852 0,09839117 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03056852 0,0982617 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03056852 0,09813258 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,03056852 0,0980038 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03056852 0,09787535 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03056852 0,09774724 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03056852 0,09761947 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03056852 0,09749203 ! activated T cell proliferation GO:0050798 16 5 0,000 0,03056852 0,09736492 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03056852 0,09723814 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03056852 0,0971117 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03056852 0,09698558 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03056852 0,09685979 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03056852 0,09673432 ! response to arsenic GO:0046685 11 5 0,000 0,03056852 0,09660918 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,03056852 0,09648436 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03056852 0,09635986 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,03056852 0,09623569 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03056852 0,09611183 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03056852 0,0959883 ! response to mercury ion GO:0046689 8 5 0,000 0,03056852 0,09586508 ! response to cadmium ion GO:0046686 7 5 0,000 0,03056852 0,09574217 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03056852 0,09561958 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03056852 0,09549731 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03056852 0,09537534 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03056852 0,09525369 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03056852 0,09513235 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03056852 0,09501132 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03056852 0,09489059 ! decidualization GO:0046697 11 5 0,000 0,03056852 0,09477017 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03056852 0,09465006 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03056852 0,09453025 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03056852 0,09441074 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03056852 0,09429153 ! embryonic cleavage GO:0040016 6 5 0,000 0,03056852 0,09417263 ! peroxisome fission GO:0016559 5 5 0,000 0,03056852 0,09405402 ! histone demethylation GO:0016577 13 5 0,000 0,03056852 0,09393572 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03056852 0,09381771 ! mitotic recombination GO:0006312 9 5 0,000 0,03056852 0,09369999 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03056852 0,09358257 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03056852 0,09346545 ! metaphase plate congression GO:0051310 7 5 0,000 0,03056852 0,09334862 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03056852 0,09323208 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03056852 0,09311583 ! enteric nervous system development GO:0048484 8 5 0,000 0,03056852 0,09299987 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03056852 0,0928842 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03056852 0,09276881 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,03056852 0,09265372 ! muscle cell proliferation GO:0033002 12 5 0,000 0,03056852 0,0925389 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03056852 0,09242437 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,03056852 0,09231013 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03056852 0,09219617 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03056852 0,09208248 ! metaphase GO:0051323 11 5 0,000 0,03056852 0,09196908 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03056852 0,09185596 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03056852 0,09174311 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03056852 0,09163055 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03056852 0,09151825 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03056852 0,09140624 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03056852 0,09129449 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03056852 0,09118302 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03056852 0,09107182 ! response to redox state GO:0051775 6 5 0,000 0,03056852 0,09096089 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03056852 0,09085024 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03056852 0,09073985 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03056852 0,09062973 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03056852 0,09051987 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03056852 0,09041028 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03056852 0,09030096 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03056852 0,0901919 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03056852 0,09008311 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03056852 0,08997457 ! striatum development GO:0021756 14 5 0,000 0,03056852 0,0898663 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,03056852 0,08975829 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03056852 0,08965053 ! glial cell migration GO:0008347 10 5 0,000 0,03056852 0,08954304 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03056852 0,0894358 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03056852 0,08932882 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03056852 0,0892221 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03056852 0,08911563 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03056852 0,08900941 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03056852 0,08890345 ! neuroprotection GO:0043526 8 5 0,000 0,03056852 0,08879773 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,03056852 0,08869227 ! regulation of sensory perception GO:0051931 8 5 0,000 0,03056852 0,08858706 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03056852 0,0884821 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03056852 0,08837739 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,03056852 0,08827293 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03056852 0,08816871 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03056852 0,08806473 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03056852 0,08796101 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,03056852 0,08785752 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,03056852 0,08775428 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03056852 0,08765128 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03056852 0,08754853 ! spindle assembly GO:0051225 6 5 0,000 0,03056852 0,08744601 ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03056852 0,08734374 ! protein palmitoylation GO:0018345 12 5 0,000 0,03056852 0,0872417 ! drug metabolic process GO:0017144 7 5 0,000 0,03056852 0,0871399 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03056852 0,08703834 ! organ regeneration GO:0031100 7 5 0,000 0,03056852 0,08693701 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03056852 0,08683592 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03056852 0,08673507 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,03570422 0,10118957 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,03570422 0,10107231 ! male sex differentiation GO:0046661 93 48 1,000 0,03570422 0,10095533 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,03570422 0,10083862 ! regulation of inflammatory response GO:0050727 84 48 1,000 0,03570422 0,10072218 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,03570422 0,100606 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03656967 0,10292593 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03656967 0,10280749 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03656967 0,10268932 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03656967 0,10257142 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03656967 0,10245379 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03656967 0,10233644 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03656967 0,10221935 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03656967 0,10210252 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03656967 0,10198597 ! response to oxygen radical GO:0000305 11 6 0,000 0,03656967 0,10186968 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03656967 0,10175365 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03656967 0,10163789 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03656967 0,1015224 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03656967 0,10140716 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03656967 0,10129219 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03656967 0,10117747 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03656967 0,10106302 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03656967 0,10094882 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03656967 0,10083488 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03656967 0,1007212 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03656967 0,10060778 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03656967 0,10049461 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03656967 0,10038169 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03656967 0,10026903 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03656967 0,10015662 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03656967 0,10004447 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03656967 0,09993256 ! malate metabolic process GO:0006108 13 6 0,000 0,03656967 0,0998209 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03656967 0,0997095 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03656967 0,09959834 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03656967 0,09948743 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03656967 0,09937676 ! protein refolding GO:0042026 15 6 0,000 0,03656967 0,09926634 ! opsonization GO:0008228 8 6 0,000 0,03656967 0,09915617 ! mating behavior GO:0007617 7 6 0,000 0,03656967 0,09904624 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03656967 0,09893655 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,03656967 0,09882711 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03656967 0,09871791 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03656967 0,09860895 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03656967 0,09850023 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03656967 0,09839175 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03656967 0,09828351 ! toxin metabolic process GO:0009404 11 6 0,000 0,03656967 0,0981755 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03656967 0,09806774 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03656967 0,09796021 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03656967 0,09785291 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03656967 0,09774585 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03656967 0,09763902 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03656967 0,09753243 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03656967 0,09742607 ! thymic T cell selection GO:0045061 16 6 0,000 0,03656967 0,09731994 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03656967 0,09721405 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03656967 0,09710838 GO:0070633|transepithelial transport, ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03656967 0,09700294 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03656967 0,09689773 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03656967 0,09679275 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03656967 0,096688 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03656967 0,09658347 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03656967 0,09647917 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03656967 0,09637509 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03656967 0,09627124 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03656967 0,09616761 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03656967 0,0960642 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03656967 0,09596102 ! urea metabolic process GO:0019627 7 6 0,000 0,03656967 0,09585806 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03656967 0,09575531 ! neutrophil activation GO:0042119 7 6 0,000 0,03656967 0,09565279 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03656967 0,09555049 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03656967 0,09544841 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03656967 0,09534654 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03656967 0,09524489 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03656967 0,09514346 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03656967 0,09504224 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03656967 0,09494124 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03656967 0,09484045 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03656967 0,09473988 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03656967 0,09463952 ! carnitine transport GO:0015879 10 6 0,000 0,03656967 0,09453937 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03656967 0,09443944 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03656967 0,09433971 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03656967 0,0942402 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,03656967 0,09414089 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03656967 0,0940418 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03656967 0,09394291 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03656967 0,09384423 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03656967 0,09374576 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03656967 0,09364749 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03656967 0,09354943 GO:0045686|negative regulation of glial cell differentiation, ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03656967 0,09345158 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03656967 0,09335393 ! interaction with symbiont GO:0051702 14 6 0,000 0,03656967 0,09325648 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03656967 0,09315924 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03656967 0,0930622 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03656967 0,09296536 ! response to copper ion GO:0046688 10 6 0,000 0,03656967 0,09286872 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03656967 0,09277228 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,03656967 0,09267605 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03656967 0,09258001 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03656967 0,09248417 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03656967 0,09238853 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03656967 0,09229309 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03656967 0,09219784 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03656967 0,09210279 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03656967 0,09200794 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03656967 0,09191328 ! response to pheromone GO:0019236 6 6 0,000 0,03656967 0,09181882 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03656967 0,09172455 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03656967 0,09163047 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03656967 0,09153659 ! subpallium development GO:0021544 15 6 0,000 0,03656967 0,09144289 ! neural tube patterning GO:0021532 8 6 0,000 0,03656967 0,09134939 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03656967 0,09125609 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03656967 0,09116297 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03656967 0,09107004 ! G2 phase GO:0051319 16 6 0,000 0,03656967 0,0909773 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03656967 0,09088475 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03656967 0,09079239 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03656967 0,09070021 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03656967 0,09060822 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03656967 0,09051642 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03656967 0,09042481 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03656967 0,09033337 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03656967 0,09024213 ! receptor internalization GO:0031623 11 6 0,000 0,03656967 0,09015107 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03656967 0,09006019 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03656967 0,08996949 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03656967 0,08987898 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03656967 0,08978865 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03656967 0,0896985 ! protein deubiquitination GO:0016579 16 6 0,000 0,03656967 0,08960853 ! protein destabilization GO:0031648 9 6 0,000 0,03656967 0,08951875 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03656967 0,08942914 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03656967 0,08933971 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03656967 0,08925046 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03656967 0,08916139 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03656967 0,08907249 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03656967 0,08898377 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03656967 0,08889523 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03656967 0,08880687 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03656967 0,08871868 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03656967 0,08863066 ! neural plate development GO:0001840 9 6 0,000 0,03656967 0,08854282 ! catecholamine transport GO:0051937 9 6 0,000 0,03656967 0,08845516 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03656967 0,08836766 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03656967 0,08828034 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03656967 0,0881932 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03656967 0,08810622 ! maternal placenta development GO:0001893 12 6 0,000 0,03656967 0,08801942 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03656967 0,08793278 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03656967 0,08784632 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03656967 0,08776003 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03656967 0,0876739 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03656967 0,08758795 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03656967 0,08750216 GO:0055081|anion homeostasis, ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,03707486 0,08862414 ! protein homooligomerization GO:0051260 84 49 1,000 0,03707486 0,08853751 ! induction of apoptosis by extracellular signals GO:0008624 99 50 1,000 0,03846546 0,09176866 ! endocrine system development GO:0035270 109 50 1,000 0,03846546 0,09167913 ! regulation of cell projection organization GO:0031344 135 51 1,000 0,03987572 0,09494774 ! response to temperature stimulus GO:0009266 84 51 1,000 0,03987572 0,09485529 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,03987572 0,09476302 ! positive regulation of binding GO:0051099 88 52 1,000 0,04130535 0,09806509 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,04130535 0,09796988 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,04130535 0,09787486 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,04130535 0,09778002 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,04130535 0,09768536 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,04130535 0,09759089 ! tRNA transcription GO:0009304 17 7 0,000 0,04253384 0,1003963 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04253384 0,1002994 GO:0045346|regulation of MHC class II biosynthetic process, ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04253384 0,10020268 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04253384 0,10010614 ! sleep GO:0030431 16 7 0,000 0,04253384 0,10000979 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04253384 0,09991363 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04253384 0,09981765 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04253384 0,09972186 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04253384 0,09962625 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04253384 0,09953082 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04253384 0,09943557 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04253384 0,09934051 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04253384 0,09924563 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04253384 0,09915093 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04253384 0,09905641 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04253384 0,09896207 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04253384 0,09886791 ! glycolipid transport GO:0046836 11 7 0,000 0,04253384 0,09877393 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04253384 0,09868013 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04253384 0,0985865 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04253384 0,09849306 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04253384 0,09839979 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04253384 0,09830669 ! mRNA stabilization GO:0048255 18 7 0,000 0,04253384 0,09821378 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,04253384 0,09812103 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04253384 0,09802847 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04253384 0,09793607 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04253384 0,09784386 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04253384 0,09775181 ! lipoprotein transport GO:0042953 14 7 0,000 0,04253384 0,09765994 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04253384 0,09756824 ! rhythmic behavior GO:0007622 17 7 0,000 0,04253384 0,09747671 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04253384 0,09738536 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04253384 0,09729417 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04253384 0,09720316 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04253384 0,09711231 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04253384 0,09702164 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04253384 0,09693113 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04253384 0,0968408 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04253384 0,09675063 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04253384 0,09666063 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04253384 0,09657079 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04253384 0,09648113 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04253384 0,09639163 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04253384 0,09630229 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04253384 0,09621313 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04253384 0,09612412 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04253384 0,09603528 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04253384 0,09594661 ! adrenal gland development GO:0030325 17 7 0,000 0,04253384 0,0958581 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04253384 0,09576975 ! ovulation GO:0030728 10 7 0,000 0,04253384 0,09568156 ! adenohypophysis development GO:0021984 11 7 0,000 0,04253384 0,09559354 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04253384 0,09550568 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04253384 0,09541798 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04253384 0,09533044 ! microtubule nucleation GO:0007020 21 7 0,000 0,04253384 0,09524306 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04253384 0,09515584 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04253384 0,09506878 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04253384 0,09498188 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04253384 0,09489514 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04253384 0,09480855 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04253384 0,09472213 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04253384 0,09463586 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04253384 0,09454975 ! galactose metabolic process GO:0006012 13 7 0,000 0,04253384 0,0944638 ! vesicle fusion GO:0006906 20 7 0,000 0,04253384 0,094378 ! response to dietary excess GO:0002021 8 7 0,000 0,04253384 0,09429235 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04253384 0,09420687 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04253384 0,09412154 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04253384 0,09403636 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,04253384 0,09395133 ! nucleoside transport GO:0015858 11 7 0,000 0,04253384 0,09386646 ! nucleoside salvage GO:0043174 11 7 0,000 0,04253384 0,09378175 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04253384 0,09369718 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04253384 0,09361277 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04253384 0,09352851 ! parturition GO:0007567 16 7 0,000 0,04253384 0,0934444 ! rRNA modification GO:0000154 14 7 0,000 0,04253384 0,09336044 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04253384 0,09327664 ! spindle checkpoint GO:0031577 16 7 0,000 0,04253384 0,09319298 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04253384 0,09310948 ! monocyte differentiation GO:0030224 16 7 0,000 0,04253384 0,09302612 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04253384 0,09294291 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04253384 0,09285985 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04253384 0,09277694 ! fibrinolysis GO:0042730 11 7 0,000 0,04253384 0,09269418 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,04253384 0,09261156 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04253384 0,0925291 ! eating behavior GO:0042755 8 7 0,000 0,04253384 0,09244677 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04253384 0,0923646 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04253384 0,09228257 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04253384 0,09220069 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04253384 0,09211895 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,04253384 0,09203736 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04253384 0,09195591 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04253384 0,0918746 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04253384 0,09179344 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04253384 0,09171242 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04253384 0,09163155 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04253384 0,09155082 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,04253384 0,09147022 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04253384 0,09138978 ! histone ubiquitination GO:0016574 9 7 0,000 0,04253384 0,09130947 ! regulation of meiosis GO:0040020 12 7 0,000 0,04253384 0,0912293 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04253384 0,09114928 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04253384 0,09106939 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04253384 0,09098965 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04253384 0,09091004 ! transcription termination GO:0006353 14 7 0,000 0,04253384 0,09083057 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04253384 0,09075124 ! anaphase GO:0051322 18 7 0,000 0,04253384 0,09067206 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04253384 0,090593 ! axonal fasciculation GO:0007413 19 7 0,000 0,04253384 0,09051409 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04253384 0,09043531 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04253384 0,09035667 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04253384 0,09027817 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04253384 0,0901998 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04253384 0,09012157 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04253384 0,09004348 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04253384 0,08996552 ! antibiotic transport GO:0042891 9 7 0,000 0,04253384 0,08988769 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04253384 0,08981 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04253384 0,08973245 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04253384 0,08965503 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04253384 0,08957774 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04253384 0,08950058 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04253384 0,08942356 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04253384 0,08934667 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04253384 0,08926991 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04253384 0,08919328 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04253384 0,08911679 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04253384 0,08904042 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04253384 0,08896419 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04253384 0,08888809 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04253384 0,08881212 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04253384 0,08873627 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04253384 0,08866056 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04253384 0,08858497 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04253384 0,08850952 ! muscle adaptation GO:0043500 13 7 0,000 0,04253384 0,08843419 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04253384 0,08835899 ! retina homeostasis GO:0001895 12 7 0,000 0,04253384 0,08828392 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04253384 0,08820898 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04253384 0,08813416 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04253384 0,08805947 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04253384 0,08798491 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,04275407 0,08836564 ! synapse organization GO:0050808 102 53 1,000 0,04275407 0,08829094 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,04422157 0,09124433 ! protein amino acid lipidation GO:0006497 109 54 1,000 0,04422157 0,09116733 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,04422157 0,09109046 ! regulation of cell shape GO:0008360 142 54 1,000 0,04422157 0,09101372 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,0472118 0,09708623 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,0472118 0,09700457 ! RNA elongation GO:0006354 90 56 1,000 0,0472118 0,09692306 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04846126 0,09940458 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04846126 0,09932118 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04846126 0,09923793 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04846126 0,09915482 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04846126 0,09907184 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04846126 0,09898901 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04846126 0,09890631 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04846126 0,09882375 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04846126 0,09874133 ! meiotic prophase I GO:0007128 14 8 0,000 0,04846126 0,09865904 ! response to zinc ion GO:0010043 12 8 0,000 0,04846126 0,09857689 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04846126 0,09849488 ! oligopeptide transport GO:0006857 16 8 0,000 0,04846126 0,09841301 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04846126 0,09833127 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04846126 0,09824967 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04846126 0,0981682 ! signal peptide processing GO:0006465 12 8 0,000 0,04846126 0,09808687 ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04846126 0,09800567 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04846126 0,09792461 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04846126 0,09784368 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04846126 0,09776288 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04846126 0,09768222 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04846126 0,09760169 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04846126 0,09752129 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04846126 0,09744103 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04846126 0,0973609 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04846126 0,0972809 ! reflex GO:0060004 17 8 0,000 0,04846126 0,09720103 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04846126 0,09712129 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04846126 0,09704168 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04846126 0,0969622 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04846126 0,09688286 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04846126 0,09680364 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04846126 0,09672455 ! histidine catabolic process GO:0006548 10 8 0,000 0,04846126 0,09664559 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04846126 0,09656676 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04846126 0,09648806 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04846126 0,09640949 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04846126 0,09633104 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04846126 0,09625272 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04846126 0,09617453 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04846126 0,09609647 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04846126 0,09601853 ! macrophage activation GO:0042116 13 8 0,000 0,04846126 0,09594072 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04846126 0,09586304 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04846126 0,09578548 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04846126 0,09570804 ! purine salvage GO:0043101 12 8 0,000 0,04846126 0,09563074 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04846126 0,09555355 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04846126 0,09547649 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04846126 0,09539956 ! osteoblast development GO:0002076 17 8 0,000 0,04846126 0,09532275 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04846126 0,09524606 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04846126 0,09516949 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04846126 0,09509305 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04846126 0,09501673 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04846126 0,09494054 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04846126 0,09486446 ! intermediate filament organization GO:0045109 12 8 0,000 0,04846126 0,09478851 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04846126 0,09471268 ! cellular extravasation GO:0045123 13 8 0,000 0,04846126 0,09463697 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04846126 0,09456138 ! response to antibiotic GO:0046677 11 8 0,000 0,04846126 0,09448591 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04846126 0,09441057 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04846126 0,09433534 ! response to tropane GO:0014073 15 8 0,000 0,04846126 0,09426023 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04846126 0,09418524 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04846126 0,09411037 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04846126 0,09403562 ! mast cell activation GO:0045576 14 8 0,000 0,04846126 0,09396099 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04846126 0,09388648 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04846126 0,09381208 ! gas homeostasis GO:0033483 14 8 0,000 0,04846126 0,09373781 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04846126 0,09366365 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04846126 0,09358961 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04846126 0,09351568 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04846126 0,09344187 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04846126 0,09336818 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04846126 0,0932946 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04846126 0,09322114 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04846126 0,0931478 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04846126 0,09307457 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04846126 0,09300145 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04846126 0,09292845 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04846126 0,09285557 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04846126 0,0927828 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04846126 0,09271014 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04846126 0,0926376 ! hormone catabolic process GO:0042447 17 8 0,000 0,04846126 0,09256517 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04846126 0,09249285 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04846126 0,09242065 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04846126 0,09234856 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04846126 0,09227658 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04846126 0,09220471 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04846126 0,09213296 ! adult feeding behavior GO:0008343 10 8 0,000 0,04846126 0,09206131 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04846126 0,09198978 ! ATP catabolic process GO:0006200 11 8 0,000 0,04846126 0,09191836 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04846126 0,09184705 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04846126 0,09177585 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04846126 0,09170476 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04846126 0,09163379 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04846126 0,09156292 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04846126 0,09149216 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04846126 0,09142151 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04846126 0,09135096 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04846126 0,09128053 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04846126 0,09121021 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04846126 0,09113999 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04846126 0,09106988 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04846126 0,09099989 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04846126 0,09092999 ! protein prenylation GO:0018342 21 8 0,000 0,04846126 0,09086021 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04846126 0,09079053 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04846126 0,09072096 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04846126 0,09065149 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04846126 0,09058214 ! muscle fiber development GO:0048747 131 57 1,000 0,04873397 0,09102225 ! heart morphogenesis GO:0003007 105 57 1,000 0,04873397 0,09095271 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,05027381 0,09375489 ! lipoprotein biosynthetic process GO:0042158 115 58 1,000 0,05027381 0,09368338 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,05027381 0,09361197 ! lipid modification GO:0030258 112 60 1,000 0,05340537 0,09936734 ! regulation of endocytosis GO:0030100 104 60 1,000 0,05340537 0,09929172 ! axon extension GO:0048675 16 9 0,000 0,05435214 0,10097512 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,05435214 0,10089839 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,05435214 0,10082178 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05435214 0,10074528 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,05435214 0,1006689 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,05435214 0,10059264 ! reproductive behavior GO:0019098 22 9 0,000 0,05435214 0,10051649 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05435214 0,10044046 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,05435214 0,10036454 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,05435214 0,10028873 ! UTP metabolic process GO:0046051 10 9 0,000 0,05435214 0,10021305 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,05435214 0,10013747 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,05435214 0,10006201 ! artery development GO:0060840 25 9 0,000 0,05435214 0,09998666 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,05435214 0,09991143 ! equilibrioception GO:0050957 20 9 0,000 0,05435214 0,0998363 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,05435214 0,0997613 ! chemosensory behavior GO:0007635 21 9 0,000 0,05435214 0,0996864 ! microtubule bundle formation GO:0001578 22 9 0,000 0,05435214 0,09961162 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,05435214 0,09953695 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05435214 0,09946239 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,05435214 0,09938794 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,05435214 0,0993136 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,05435214 0,09923938 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,05435214 0,09916526 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05435214 0,09909126 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05435214 0,09901736 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,05435214 0,09894358 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,05435214 0,09886991 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,05435214 0,09879634 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,05435214 0,09872289 ! glycine catabolic process GO:0006546 15 9 0,000 0,05435214 0,09864954 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,05435214 0,09857631 ! endosome organization GO:0007032 20 9 0,000 0,05435214 0,09850318 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05435214 0,09843016 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,05435214 0,09835725 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05435214 0,09828444 ! mannose metabolic process GO:0006013 13 9 0,000 0,05435214 0,09821175 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,05435214 0,09813916 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,05435214 0,09806668 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,05435214 0,09799431 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,05435214 0,09792204 ! receptor clustering GO:0043113 20 9 0,000 0,05435214 0,09784988 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,05435214 0,09777782 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05435214 0,09770588 ! retinol metabolic process GO:0042572 20 9 0,000 0,05435214 0,09763403 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,05435214 0,0975623 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,05435214 0,09749066 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,05435214 0,09741914 ! macrophage differentiation GO:0030225 15 9 0,000 0,05435214 0,09734772 ! oligodendrocyte development GO:0014003 11 9 0,000 0,05435214 0,0972764 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,05435214 0,09720519 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05435214 0,09713408 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,05435214 0,09706307 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05435214 0,09699217 ! response to amine stimulus GO:0014075 13 9 0,000 0,05435214 0,09692138 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05435214 0,09685068 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,05435214 0,09678009 ! erythrocyte development GO:0048821 17 9 0,000 0,05435214 0,0967096 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05435214 0,09663922 ! renal water homeostasis GO:0003091 15 9 0,000 0,05435214 0,09656893 ! postreplication repair GO:0006301 25 9 0,000 0,05435214 0,09649875 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,05435214 0,09642867 ! icosanoid secretion GO:0032309 15 9 0,000 0,05435214 0,0963587 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05435214 0,09628882 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,05435214 0,09621905 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,05435214 0,09614937 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,05435214 0,0960798 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05435214 0,09601033 ! sterol catabolic process GO:0016127 14 9 0,000 0,05435214 0,09594096 GO:0006707|cholesterol catabolic process, ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,05435214 0,09587169 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,05435214 0,09580251 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,05435214 0,09573344 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,05435214 0,09566447 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,05435214 0,0955956 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,05435214 0,09552682 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,05435214 0,09545815 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,05435214 0,09538957 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,05435214 0,09532109 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05435214 0,09525272 ! purine base metabolic process GO:0006144 25 9 0,000 0,05435214 0,09518443 ! pigment granule transport GO:0051904 17 9 0,000 0,05435214 0,09511625 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,05435214 0,09504816 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,05435214 0,09498018 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05435214 0,09491228 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,05435214 0,09484449 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,05435214 0,09477679 ! mitochondrion localization GO:0051646 18 9 0,000 0,05435214 0,09470919 ! camera-type eye development GO:0043010 126 61 1,000 0,05499656 0,09576378 ! viral reproductive process GO:0022415 132 62 1,000 0,05660432 0,09849314 ! regulation of mitosis GO:0007088 112 63 1,000 0,05822841 0,10124698 GO:0051783|regulation of nuclear division, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,06020672 0,10461239 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,06020672 0,10453804 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,06020672 0,1044638 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,06020672 0,10438966 ! associative learning GO:0008306 21 10 0,000 0,06020672 0,10431562 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,06020672 0,10424169 ! phosphate transport GO:0006817 24 10 0,000 0,06020672 0,10416787 ! cell volume homeostasis GO:0006884 17 10 0,000 0,06020672 0,10409414 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,06020672 0,10402053 ! CTP metabolic process GO:0046036 11 10 0,000 0,06020672 0,10394701 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,06020672 0,10387361 ! GTP metabolic process GO:0046039 11 10 0,000 0,06020672 0,1038003 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,06020672 0,1037271 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,06020672 0,103654 ! social behavior GO:0035176 29 10 0,000 0,06020672 0,103581 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,06020672 0,10350811 ! androgen metabolic process GO:0008209 17 10 0,000 0,06020672 0,10343532 ! phospholipid efflux GO:0033700 19 10 0,000 0,06020672 0,10336263 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,06020672 0,10329005 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,06020672 0,10321756 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,06020672 0,10314518 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,06020672 0,1030729 ! lung alveolus development GO:0048286 26 10 0,000 0,06020672 0,10300072 ! pathogenesis GO:0009405 17 10 0,000 0,06020672 0,10292864 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06020672 0,10285666 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,06020672 0,10278478 ! endoderm development GO:0007492 18 10 0,000 0,06020672 0,10271301 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,06020672 0,10264133 ! arginine catabolic process GO:0006527 17 10 0,000 0,06020672 0,10256975 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,06020672 0,10249828 ! proline metabolic process GO:0006560 13 10 0,000 0,06020672 0,1024269 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,06020672 0,10235562 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,06020672 0,10228444 ! V(D)J recombination GO:0033151 34 10 0,000 0,06020672 0,10221336 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,06020672 0,10214238 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,06020672 0,1020715 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,06020672 0,10200071 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,06020672 0,10193002 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,06020672 0,10185944 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,06020672 0,10178895 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,06020672 0,10171855 ! ruffle organization GO:0031529 17 10 0,000 0,06020672 0,10164826 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,06020672 0,10157806 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,06020672 0,10150795 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,06020672 0,10143795 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,06020672 0,10136804 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,06020672 0,10129823 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,06020672 0,10122851 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,06020672 0,10115889 ! regulation of bone resorption GO:0045124 25 10 0,000 0,06020672 0,10108936 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,06020672 0,10101994 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,06020672 0,1009506 ! segment specification GO:0007379 15 10 0,000 0,06020672 0,10088136 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,06020672 0,10081222 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,06020672 0,10074317 ! blastoderm segmentation GO:0007350 19 10 0,000 0,06020672 0,10067421 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,06020672 0,10060535 ! response to dsRNA GO:0043331 23 10 0,000 0,06020672 0,10053659 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,06020672 0,10046791 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,06020672 0,10039933 ! melanosome localization GO:0032400 16 10 0,000 0,06020672 0,10033085 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,06020672 0,10026246 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,06020672 0,10019416 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,06020672 0,10012595 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,06020672 0,10005784 ! induction of an organ GO:0001759 17 10 0,000 0,06020672 0,09998982 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,06020672 0,09992189 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,06020672 0,09985406 ! protein sumoylation GO:0016925 17 10 0,000 0,06020672 0,09978631 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,06020672 0,09971866 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,06020672 0,0996511 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06020672 0,09958363 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,06020672 0,09951626 ! salivary gland development GO:0007431 28 10 0,000 0,06020672 0,09944897 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,06020672 0,09938177 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,06020672 0,09931467 ! midbrain development GO:0030901 14 10 0,000 0,06020672 0,09924766 ! musculoskeletal movement GO:0050881 16 10 0,000 0,06020672 0,09918073 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,06020672 0,0991139 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,06020672 0,09904716 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,06020672 0,0989805 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,06020672 0,09891394 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,06020672 0,09884746 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,06020672 0,09878108 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,06020672 0,09871478 ! detection of calcium ion GO:0005513 24 10 0,000 0,06020672 0,09864858 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,06020672 0,09858246 ! blastocyst formation GO:0001825 18 10 0,000 0,06020672 0,09851643 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,06020672 0,09845049 ! cerebellar cortex development GO:0021695 16 10 0,000 0,06020672 0,09838463 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,06020672 0,09831887 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,06020672 0,09825319 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,06020672 0,0981876 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,06020672 0,0981221 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,06152449 0,10020288 GO:0048609|reproductive process in a multicellular organism, ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,06319596 0,10285659 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 1,000 0,06488273 0,10553163 ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,06488273 0,10546141 ! secondary metabolic process GO:0019748 125 67 1,000 0,06488273 0,10539129 ! respiratory burst GO:0045730 17 11 0,000 0,06602522 0,10717583 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,06602522 0,10710466 ! thyroid gland development GO:0030878 26 11 0,000 0,06602522 0,10703359 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,06602522 0,10696261 ! synapsis GO:0007129 14 11 0,000 0,06602522 0,10689173 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,06602522 0,10682094 ! response to pain GO:0048265 27 11 0,000 0,06602522 0,10675024 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,06602522 0,10667964 ! blood vessel remodeling GO:0001974 30 11 0,000 0,06602522 0,10660913 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,06602522 0,10653872 ! bone resorption GO:0045453 16 11 0,000 0,06602522 0,10646839 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,06602522 0,10639816 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06602522 0,10632803 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06602522 0,10625798 ! melanocyte differentiation GO:0030318 20 11 0,000 0,06602522 0,10618803 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,06602522 0,10611817 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,06602522 0,1060484 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,06602522 0,10597872 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,06602522 0,10590914 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,06602522 0,10583964 ! UV protection GO:0009650 20 11 0,000 0,06602522 0,10577024 ! adult heart development GO:0007512 16 11 0,000 0,06602522 0,10570093 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,06602522 0,10563171 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06602522 0,10556258 ! macroautophagy GO:0016236 19 11 0,000 0,06602522 0,10549354 ! temperature homeostasis GO:0001659 18 11 0,000 0,06602522 0,10542459 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,06602522 0,10535573 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,06602522 0,10528696 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,06602522 0,10521828 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,06602522 0,10514969 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,06602522 0,10508118 ! regulation of organ growth GO:0046620 14 11 0,000 0,06602522 0,10501277 ! pigment granule localization GO:0051875 20 11 0,000 0,06602522 0,10494445 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,06602522 0,10487621 ! vasoconstriction GO:0042310 20 11 0,000 0,06602522 0,10480807 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,06602522 0,10474001 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06602522 0,10467204 ! embryonic axis specification GO:0000578 19 11 0,000 0,06602522 0,10460416 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,06602522 0,10453637 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06602522 0,10446866 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,06602522 0,10440105 ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,06602522 0,10433352 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,06602522 0,10426607 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,06602522 0,10419872 ! prophase GO:0051324 17 11 0,000 0,06602522 0,10413145 ! nucleosome positioning GO:0016584 15 11 0,000 0,06602522 0,10406427 ! regulation of isotype switching GO:0045191 24 11 0,000 0,06602522 0,10399717 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,06602522 0,10393017 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,06602522 0,10386324 ! apical protein localization GO:0045176 18 11 0,000 0,06602522 0,10379641 ! acid secretion GO:0046717 20 11 0,000 0,06602522 0,10372966 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06602522 0,10366299 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,06602522 0,10359641 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,06602522 0,10352992 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,06602522 0,10346351 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,06602522 0,10339719 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,06602522 0,10333095 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,06602522 0,1032648 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06602522 0,10319873 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,06602522 0,10313275 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,06602522 0,10306685 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,06602522 0,10300103 ! activation of innate immune response GO:0002218 16 11 0,000 0,06602522 0,1029353 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,06602522 0,10286965 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,06602522 0,10280409 ! lysogeny GO:0030069 22 11 0,000 0,06602522 0,10273861 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06602522 0,10267321 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,06602522 0,1026079 ! sequestering of metal ion GO:0051238 15 11 0,000 0,06602522 0,10254267 ! nucleus localization GO:0051647 22 11 0,000 0,06602522 0,10247752 ! detection of external stimulus GO:0009581 102 68 1,000 0,06658453 0,10328 ! viral reproduction GO:0016032 142 68 1,000 0,06658453 0,10321447 ! cell projection assembly GO:0030031 138 68 1,000 0,06658453 0,10314902 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,06830111 0,1057412 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,07180786 0,11109981 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,07180786 0,11102949 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,07180786 0,11095927 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,07180786 0,11088913 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,07180786 0,11081908 ! protein complex disassembly GO:0043241 28 12 0,000 0,07180786 0,11074912 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,07180786 0,11067924 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,07180786 0,11060946 ! hippocampus development GO:0021766 29 12 0,000 0,07180786 0,11053976 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,07180786 0,11047015 ! T cell proliferation GO:0042098 32 12 0,000 0,07180786 0,11040063 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,07180786 0,1103312 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,07180786 0,11026185 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,07180786 0,11019259 ! drug transport GO:0015893 16 12 0,000 0,07180786 0,11012342 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,07180786 0,11005433 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,07180786 0,10998533 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,07180786 0,10991642 ! polyamine metabolic process GO:0006595 18 12 0,000 0,07180786 0,10984759 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,07180786 0,10977885 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,07180786 0,10971019 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 21 12 0,000 0,07180786 0,10964163 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,07180786 0,10957314 ! entry into host cell GO:0030260 34 12 0,000 0,07180786 0,10950474 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07180786 0,10943643 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,07180786 0,1093682 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,07180786 0,10930006 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,07180786 0,10923201 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,07180786 0,10916403 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,07180786 0,10909614 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,07180786 0,10902834 ! snRNA metabolic process GO:0016073 30 12 0,000 0,07180786 0,10896062 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,07180786 0,10889299 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,07180786 0,10882543 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,07180786 0,10875797 ! fucose catabolic process GO:0019317 25 12 0,000 0,07180786 0,10869058 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,07180786 0,10862328 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,07180786 0,10855606 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,07180786 0,10848893 ! zymogen activation GO:0031638 18 12 0,000 0,07180786 0,10842188 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,07180786 0,10835491 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,07180786 0,10828802 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,07180786 0,10822122 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,07180786 0,1081545 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,07180786 0,10808786 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,07180786 0,10802131 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,07180786 0,10795483 ! defense response to fungus GO:0050832 15 12 0,000 0,07180786 0,10788844 ! developmental induction GO:0031128 22 12 0,000 0,07180786 0,10782213 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,07180786 0,1077559 ! lamellipodium assembly GO:0030032 24 12 0,000 0,07180786 0,10768975 ! response to cold GO:0009409 17 12 0,000 0,07180786 0,10762368 ! establishment of cell polarity GO:0030010 21 12 0,000 0,07180786 0,10755769 ! regulation of synapse organization GO:0050807 18 12 0,000 0,07180786 0,10749179 ! localization within membrane GO:0051668 26 12 0,000 0,07180786 0,10742596 ! carbohydrate transport GO:0008643 114 72 1,000 0,07353713 0,10994566 ! humoral immune response GO:0006959 115 73 1,000 0,07531043 0,11252805 ! acute inflammatory response GO:0002526 118 74 1,000 0,0770973 0,11512756 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,07755486 0,11574008 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07755486 0,11566942 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,07755486 0,11559885 ! regulation of chemokine production GO:0032642 18 13 0,000 0,07755486 0,11552836 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,07755486 0,11545796 ! peroxisomal transport GO:0043574 28 13 0,000 0,07755486 0,11538764 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,07755486 0,11531741 ! cartilage condensation GO:0001502 22 13 0,000 0,07755486 0,11524727 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,07755486 0,11517721 ! organelle fusion GO:0048284 36 13 0,000 0,07755486 0,11510724 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,07755486 0,11503735 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,07755486 0,11496754 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,07755486 0,11489782 ! endocrine pancreas development GO:0031018 25 13 0,000 0,07755486 0,11482819 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,07755486 0,11475864 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,07755486 0,11468917 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,07755486 0,11461979 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,07755486 0,11455049 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,07755486 0,11448128 ! methionine metabolic process GO:0006555 31 13 0,000 0,07755486 0,11441214 ! plasma membrane organization GO:0007009 27 13 0,000 0,07755486 0,1143431 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,07755486 0,11427413 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,07755486 0,11420525 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,07755486 0,11413645 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,07755486 0,11406774 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,07755486 0,1139991 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,07755486 0,11393055 ! exocrine system development GO:0035272 34 13 0,000 0,07755486 0,11386209 ! asymmetric protein localization GO:0008105 24 13 0,000 0,07755486 0,1137937 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,07755486 0,1137254 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,07755486 0,11365718 ! L-glutamate transport GO:0015813 30 13 0,000 0,07755486 0,11358904 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,07755486 0,11352098 ! protein homotetramerization GO:0051289 24 13 0,000 0,07755486 0,113453 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,07755486 0,11338511 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,07755486 0,11331729 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,07755486 0,11324956 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,07755486 0,11318191 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,07755486 0,11311434 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07755486 0,11304684 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,07755486 0,11297943 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,07755486 0,1129121 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,07755486 0,11284486 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07755486 0,11277769 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,07755486 0,1127106 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,07755486 0,11264359 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,07755486 0,11257666 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,07755486 0,11250981 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,07755486 0,11244303 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,07755486 0,11237634 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,07755486 0,11230973 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07755486 0,11224319 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,07755486 0,11217674 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,07755486 0,11211036 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,07755486 0,11204406 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,07755486 0,11197784 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,07755486 0,1119117 ! acrosome reaction GO:0007340 19 13 0,000 0,07755486 0,11184564 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,07755486 0,11177965 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,07755486 0,11171375 ! eye development GO:0001654 155 75 1,000 0,07889751 0,1135808 ! axon guidance GO:0007411 162 75 1,000 0,07889751 0,11351391 ! rhythmic process GO:0048511 142 75 1,000 0,07889751 0,1134471 ! regulation of blood pressure GO:0008217 134 76 1,000 0,08071084 0,11598623 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,08253706 0,11854087 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,08253706 0,11847123 ! rRNA transcription GO:0009303 28 14 0,000 0,08326643 0,11944797 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,08326643 0,11937787 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,08326643 0,11930785 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,08326643 0,11923792 ! non-recombinational repair GO:0000726 29 14 0,000 0,08326643 0,11916807 GO:0006303|double-strand break repair via nonhomologous end joining, ! retina development in camera-type eye GO:0060041 28 14 0,000 0,08326643 0,11909829 ! RNA polyadenylation GO:0043631 32 14 0,000 0,08326643 0,11902861 ! lipid localization GO:0010876 32 14 0,000 0,08326643 0,118959 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,08326643 0,11888947 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,08326643 0,11882003 ! regulated secretory pathway GO:0045055 24 14 0,000 0,08326643 0,11875066 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,08326643 0,11868138 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,08326643 0,11861218 ! arginine metabolic process GO:0006525 21 14 0,000 0,08326643 0,11854306 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,08326643 0,11847402 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,08326643 0,11840506 ! regulation of heart rate GO:0002027 25 14 0,000 0,08326643 0,11833618 ! organic alcohol transport GO:0015850 29 14 0,000 0,08326643 0,11826738 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,08326643 0,11819866 ! embryo implantation GO:0007566 30 14 0,000 0,08326643 0,11813002 ! neutral amino acid transport GO:0015804 28 14 0,000 0,08326643 0,11806146 ! bone mineralization GO:0030282 18 14 0,000 0,08326643 0,11799297 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,08326643 0,11792457 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,08326643 0,11785625 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,08326643 0,11778801 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,08326643 0,11771984 ! ribosome assembly GO:0042255 18 14 0,000 0,08326643 0,11765176 ! cerebellum development GO:0021549 23 14 0,000 0,08326643 0,11758375 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,08326643 0,11751582 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,08326643 0,11744797 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,08326643 0,1173802 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,08326643 0,11731251 ! NADP metabolic process GO:0006739 24 14 0,000 0,08326643 0,11724489 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,08326643 0,11717735 ! oxygen transport GO:0015671 22 14 0,000 0,08326643 0,11710989 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,08326643 0,11704251 ! male genitalia development GO:0030539 26 14 0,000 0,08326643 0,11697521 ! regulation of RNA stability GO:0043487 33 14 0,000 0,08326643 0,11690798 ! regulation of axon extension GO:0030516 43 14 0,000 0,08326643 0,11684083 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,08326643 0,11677376 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,08326643 0,11670676 ! lipoprotein metabolic process GO:0042157 147 78 1,000 0,08437592 0,11819403 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,08437592 0,11812629 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 1,000 0,08809074 0,1232564 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,08809074 0,12318584 ! lactation GO:0007595 30 15 0,000 0,0889428 0,12430621 ! reproductive cellular process GO:0048610 22 15 0,000 0,0889428 0,12423514 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,0889428 0,12416415 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,0889428 0,12409324 ! superoxide anion generation GO:0042554 22 15 0,000 0,0889428 0,12402241 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,0889428 0,12395166 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,0889428 0,12388099 ! copper ion transport GO:0006825 22 15 0,000 0,0889428 0,1238104 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,0889428 0,1237399 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,0889428 0,12366947 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,0889428 0,12359912 ! response to cAMP GO:0051591 25 15 0,000 0,0889428 0,12352886 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,0889428 0,12345867 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,0889428 0,12338856 ! response to hexose stimulus GO:0009746 25 15 0,000 0,0889428 0,12331853 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,0889428 0,12324859 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,0889428 0,12317872 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,0889428 0,12310893 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,0889428 0,12303922 ! regulation of exocytosis GO:0017157 26 15 0,000 0,0889428 0,12296958 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,0889428 0,12290003 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,0889428 0,12283056 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,0889428 0,12276116 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,0889428 0,12269184 ! regulation of vasodilation GO:0042312 27 15 0,000 0,0889428 0,12262261 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,0889428 0,12255344 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,0889428 0,12248436 ! water homeostasis GO:0030104 28 15 0,000 0,0889428 0,12241536 ! cofactor transport GO:0051181 30 15 0,000 0,0889428 0,12234643 ! muscle maintenance GO:0046716 26 15 0,000 0,0889428 0,12227758 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,0889428 0,12220881 ! intestinal absorption GO:0050892 31 15 0,000 0,0889428 0,12214011 ! dopamine metabolic process GO:0042417 35 15 0,000 0,0889428 0,12207149 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,0889428 0,12200295 ! heme biosynthetic process GO:0006783 33 15 0,000 0,0889428 0,12193449 ! cell killing GO:0001906 32 15 0,000 0,0889428 0,1218661 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,0889428 0,12179779 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,0889428 0,12172956 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,0889428 0,1216614 ! actin filament polymerization GO:0030041 27 15 0,000 0,0889428 0,12159332 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,0889428 0,12152531 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,08996624 0,12285495 ! inorganic anion transport GO:0015698 156 83 1,000 0,09375233 0,1279536 ! positive regulation of cell size GO:0045793 29 16 0,000 0,09458418 0,12901683 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,09458418 0,12894484 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,09458418 0,12887292 ! bone remodeling GO:0046849 28 16 0,000 0,09458418 0,12880109 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09458418 0,12872933 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,09458418 0,12865765 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,09458418 0,12858606 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,09458418 0,12851454 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,09458418 0,12844311 ! startle response GO:0001964 28 16 0,000 0,09458418 0,12837175 ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,09458418 0,12830047 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,09458418 0,12822927 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,09458418 0,12815815 ! glutamate metabolic process GO:0006536 25 16 0,000 0,09458418 0,12808711 ! lysosomal transport GO:0007041 31 16 0,000 0,09458418 0,12801615 ! fructose metabolic process GO:0006000 25 16 0,000 0,09458418 0,12794526 ! L-amino acid transport GO:0015807 33 16 0,000 0,09458418 0,12787446 ! stem cell development GO:0048864 46 16 0,000 0,09458418 0,12780373 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,09458418 0,12773308 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,09458418 0,12766251 ! intermediate filament-based process GO:0045103 36 16 0,000 0,09458418 0,12759202 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,09458418 0,1275216 ! negative regulation of immune response GO:0050777 38 16 0,000 0,09458418 0,12745127 ! axon cargo transport GO:0008088 46 16 0,000 0,09458418 0,12738101 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,09458418 0,12731082 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,09458418 0,12724072 ! DNA replication initiation GO:0006270 28 16 0,000 0,09458418 0,12717069 ! neuron recognition GO:0008038 40 16 0,000 0,09458418 0,12710074 ! mRNA splice site selection GO:0006376 44 16 0,000 0,09458418 0,12703087 ! tissue regeneration GO:0042246 27 16 0,000 0,09458418 0,12696107 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,09458418 0,12689135 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,09458418 0,12682171 ! biomineral formation GO:0031214 22 16 0,000 0,09458418 0,12675214 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,09458418 0,12668265 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,09458418 0,12661323 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,09458418 0,12654389 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,09458418 0,12647463 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,09458418 0,12640544 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,09458418 0,12633633 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,09458418 0,12626729 ! peptide hormone processing GO:0016486 27 16 0,000 0,09458418 0,12619833 ! response to metal ion GO:0010038 158 84 1,000 0,09566249 0,1275674 ! negative regulation of transport GO:0051051 164 85 1,000 0,09758379 0,13005848 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,099516 0,13256139 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of cell killing GO:0031343 36 17 0,000 0,10019078 0,13338751 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,10019078 0,13331486 ! signal complex assembly GO:0007172 47 17 0,000 0,10019078 0,13324229 ! filopodium assembly GO:0046847 42 17 0,000 0,10019078 0,1331698 ! endothelial cell migration GO:0043542 31 17 0,000 0,10019078 0,13309738 ! gene silencing by RNA GO:0031047 38 17 0,000 0,10019078 0,13302505 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,10019078 0,13295279 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,10019078 0,13288061 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,10019078 0,13280851 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,10019078 0,13273649 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,10019078 0,13266454 ! myoblast differentiation GO:0045445 50 17 0,000 0,10019078 0,13259268 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,10019078 0,13252089 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,10019078 0,13244918 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,10019078 0,13237755 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,10019078 0,13230599 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,10019078 0,13223451 ! NAD metabolic process GO:0019674 33 17 0,000 0,10019078 0,13216311 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,10019078 0,13209179 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,10019078 0,13202054 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,10019078 0,13194937 ! genitalia development GO:0048806 32 17 0,000 0,10019078 0,13187828 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,10019078 0,13180726 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,10019078 0,13173632 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,10019078 0,13166546 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,10019078 0,13159467 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,10019078 0,13152396 ! steroid catabolic process GO:0006706 34 17 0,000 0,10019078 0,13145332 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,10019078 0,13138276 ! gas transport GO:0015669 26 17 0,000 0,10019078 0,13131228 ! organic cation transport GO:0015695 32 17 0,000 0,10019078 0,13124187 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,10019078 0,13117154 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,10019078 0,13110128 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,10576283 0,1383183 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,10576283 0,1382443 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,10576283 0,13817037 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,10576283 0,13809652 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,10576283 0,13802275 ! adult walking behavior GO:0007628 36 18 0,000 0,10576283 0,13794906 ! patterning of blood vessels GO:0001569 43 18 0,000 0,10576283 0,13787545 ! heart looping GO:0001947 34 18 0,000 0,10576283 0,13780191 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,10576283 0,13772846 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,10576283 0,13765508 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,10576283 0,13758178 ! glycine metabolic process GO:0006544 30 18 0,000 0,10576283 0,13750856 ! glutamine metabolic process GO:0006541 29 18 0,000 0,10576283 0,13743542 ! response to retinoic acid GO:0032526 31 18 0,000 0,10576283 0,13736235 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,10576283 0,13728937 ! DNA integration GO:0015074 32 18 0,000 0,10576283 0,13721646 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,10576283 0,13714362 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,10576283 0,13707087 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,10576283 0,13699819 ! neural crest cell migration GO:0001755 41 18 0,000 0,10576283 0,13692559 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,10576283 0,13685307 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,10576283 0,13678062 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,10576283 0,13670825 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,10576283 0,13663595 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,10576283 0,13656374 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,10576283 0,13649159 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,10576283 0,13641953 ! detection of bacterium GO:0016045 22 18 0,000 0,10576283 0,13634754 ! microspike assembly GO:0030035 46 18 0,000 0,10576283 0,13627563 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,10576283 0,13620379 ! response to inorganic substance GO:0010035 173 90 1,000 0,10734994 0,13817487 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,11130052 0,1431844 ! positive regulation of translation GO:0045727 31 19 0,000 0,11130052 0,14310904 ! negative regulation of defense response GO:0031348 27 19 0,000 0,11130052 0,14303376 ! neuron maturation GO:0042551 46 19 0,000 0,11130052 0,14295856 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,11130052 0,14288344 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,11130052 0,14280839 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,11130052 0,14273343 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,11130052 0,14265854 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,11130052 0,14258373 ! inositol metabolic process GO:0006020 33 19 0,000 0,11130052 0,142509 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,11130052 0,14243435 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,11130052 0,14235978 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,11130052 0,14228529 ! pigmentation during development GO:0048066 42 19 0,000 0,11130052 0,14221087 ! response to vitamin A GO:0033189 32 19 0,000 0,11130052 0,14213653 ! heme metabolic process GO:0042168 40 19 0,000 0,11130052 0,14206227 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,11130052 0,14198808 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,11130052 0,14191398 ! response to fungus GO:0009620 26 19 0,000 0,11130052 0,14183995 ! protein export from nucleus GO:0006611 40 19 0,000 0,11130052 0,141766 ! heart process GO:0003015 32 19 0,000 0,11130052 0,14169212 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,11130052 0,14161832 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,11130052 0,1415446 ! visual learning GO:0008542 38 19 0,000 0,11130052 0,14147096 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,11130052 0,14139739 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,11130052 0,1413239 ! vitamin transport GO:0051180 31 19 0,000 0,11130052 0,14125048 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,11130052 0,14117714 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,11130052 0,14110388 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,11130052 0,14103069 ! cilium assembly GO:0042384 38 19 0,000 0,11130052 0,14095758 ! female pregnancy GO:0007565 166 94 1,000 0,1153424 0,14600077 ! protein secretion GO:0009306 45 20 0,000 0,11680408 0,1477744 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,11680408 0,14769791 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,11680408 0,14762151 ! positive regulation of ossification GO:0045778 50 20 0,000 0,11680408 0,14754518 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,11680408 0,14746893 ! skin development GO:0043588 42 20 0,000 0,11680408 0,14739275 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,11680408 0,14731666 ! response to vitamin GO:0033273 36 20 0,000 0,11680408 0,14724065 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,11680408 0,14716471 ! bile acid metabolic process GO:0008206 34 20 0,000 0,11680408 0,14708885 ! retinoid metabolic process GO:0001523 34 20 0,000 0,11680408 0,14701307 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,11680408 0,14693737 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,11680408 0,14686175 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,11680408 0,1467862 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,11680408 0,14671073 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,11680408 0,14663534 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,11680408 0,14656003 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,11680408 0,14648479 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,11680408 0,14640963 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,11680408 0,14633455 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,11680408 0,14625954 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,11680408 0,14618462 ! cell-cell junction organization GO:0045216 43 20 0,000 0,11680408 0,14610977 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,11680408 0,14603499 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,11680408 0,14596029 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,11680408 0,14588567 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,11680408 0,14581112 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,11680408 0,14573666 ! regulation of glucose import GO:0046324 30 20 0,000 0,11680408 0,14566226 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,11680408 0,14558794 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,11680408 0,1455137 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,11680408 0,14543954 ! regulation of defense response GO:0031347 171 95 1,000 0,11736382 0,14606206 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,11736382 0,14598769 ! response to protein stimulus GO:0051789 158 96 1,000 0,11939418 0,14843765 ! regulation of cell killing GO:0031341 46 21 0,000 0,12227371 0,15194032 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,12227371 0,15186308 ! cAMP metabolic process GO:0046058 41 21 0,000 0,12227371 0,15178591 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,12227371 0,15170882 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,12227371 0,15163181 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,12227371 0,15155488 ! smooth muscle contraction GO:0006939 48 21 0,000 0,12227371 0,15147803 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,12227371 0,15140125 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,12227371 0,15132456 ! plasma membrane fusion GO:0045026 33 21 0,000 0,12227371 0,15124794 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,12227371 0,15117139 ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,12227371 0,15109493 ! sensory perception of pain GO:0019233 33 21 0,000 0,12227371 0,15101854 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,12227371 0,15094223 ! collagen fibril organization GO:0030199 62 21 0,000 0,12227371 0,150866 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,12227371 0,15078984 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,12227371 0,15071376 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,12227371 0,15063776 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,12227371 0,15056183 ! collagen catabolic process GO:0030574 29 21 0,000 0,12227371 0,15048598 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,12227371 0,15041021 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,12227371 0,15033451 ! actin filament-based movement GO:0030048 47 21 0,000 0,12227371 0,15025889 ! hormone metabolic process GO:0042445 171 100 1,000 0,12760133 0,15672702 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,12770962 0,15678121 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,12770962 0,15670246 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,12770962 0,1566238 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,12770962 0,15654521 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,12770962 0,1564667 ! microtubule-based transport GO:0010970 59 22 0,000 0,12770962 0,15638827 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,12770962 0,15630992 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,12770962 0,15623165 ! vacuolar transport GO:0007034 41 22 0,000 0,12770962 0,15615345 ! central nervous system neuron development GO:0021954 47 22 0,000 0,12770962 0,15607534 ! fucose metabolic process GO:0006004 44 22 0,000 0,12770962 0,1559973 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,12770962 0,15591934 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,12770962 0,15584146 ! stem cell differentiation GO:0048863 57 22 0,000 0,12770962 0,15576365 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,12770962 0,15568593 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,12770962 0,15560828 ! cytolysis GO:0019835 27 22 0,000 0,12770962 0,15553071 ! vasodilation GO:0042311 40 22 0,000 0,12770962 0,15545321 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,12770962 0,1553758 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,12770962 0,15529846 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,12770962 0,15522119 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,12770962 0,15514401 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,12770962 0,1550669 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,12770962 0,15498987 ! sarcomere organization GO:0045214 32 22 0,000 0,12770962 0,15491291 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,12770962 0,15483603 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,12770962 0,15475923 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,12770962 0,1546825 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,12770962 0,15460585 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,13311201 0,1610662 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,13311201 0,16098646 ! gluconeogenesis GO:0006094 38 23 0,000 0,13311201 0,1609068 ! glycerol metabolic process GO:0006071 40 23 0,000 0,13311201 0,16082723 ! viral genome replication GO:0019079 44 23 0,000 0,13311201 0,16074773 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,13311201 0,16066831 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,13311201 0,16058896 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,13311201 0,1605097 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,13311201 0,16043051 ! axis specification GO:0009798 43 23 0,000 0,13311201 0,16035141 ! visual behavior GO:0007632 46 23 0,000 0,13311201 0,16027238 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,13311201 0,16019342 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,13311201 0,16011455 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,13311201 0,16003575 ! peroxisome organization GO:0007031 43 23 0,000 0,13311201 0,15995703 ! lysosome organization GO:0007040 47 23 0,000 0,13311201 0,15987839 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,13311201 0,15979983 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,13311201 0,15972134 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,13311201 0,15964293 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,13311201 0,1595646 ! fatty acid transport GO:0015908 47 23 0,000 0,13311201 0,15948634 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,13311201 0,15940816 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,13311201 0,15933006 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,13311201 0,15925203 ! cell-cell recognition GO:0009988 28 23 0,000 0,13311201 0,15917408 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,13311201 0,15909621 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,13311201 0,15901841 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,13311201 0,15894069 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,1384811 0,1652708 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,1384811 0,1651901 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,1384811 0,16510948 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,1384811 0,16502894 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,1384811 0,16494848 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,1384811 0,1648681 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,1384811 0,16478779 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,1384811 0,16470756 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,1384811 0,16462741 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,1384811 0,16454734 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,1384811 0,16446735 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,1384811 0,16438743 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,1384811 0,16430759 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,1384811 0,16422783 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,1384811 0,16414815 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,1384811 0,16406854 ! membrane depolarization GO:0051899 45 24 0,000 0,1384811 0,16398901 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,1384811 0,16390956 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,1384811 0,16383019 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,1384811 0,16375089 ! platelet activation GO:0030168 41 24 0,000 0,1384811 0,16367167 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,1384811 0,16359252 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,1384811 0,16351345 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,1384811 0,16343446 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,1384811 0,16335554 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,1384811 0,1632767 ! regulation of amine transport GO:0051952 41 24 0,000 0,1384811 0,16319794 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,14381709 0,1694046 ! phototransduction GO:0007602 37 25 0,000 0,14381709 0,16932296 ! keratinization GO:0031424 37 25 0,000 0,14381709 0,1692414 ! vasculogenesis GO:0001570 49 25 0,000 0,14381709 0,16915991 ! vacuole organization GO:0007033 49 25 0,000 0,14381709 0,16907851 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,14381709 0,16899718 ! receptor metabolic process GO:0043112 53 25 0,000 0,14381709 0,16891593 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,14381709 0,16883476 ! regulation of behavior GO:0050795 48 25 0,000 0,14381709 0,16875367 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,14381709 0,16867266 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,14381709 0,16859172 ! immunoglobulin production GO:0002377 62 25 0,000 0,14381709 0,16851086 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,14381709 0,16843008 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,14381709 0,16834937 ! liver development GO:0001889 55 25 0,000 0,14381709 0,16826875 ! initiation of viral infection GO:0019059 60 26 0,000 0,14912017 0,17438994 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,14912017 0,1743065 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,14912017 0,17422314 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,14912017 0,17413985 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,14912017 0,17405665 ! digestive system process GO:0022600 49 26 0,000 0,14912017 0,17397353 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,14912017 0,17389049 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,14912017 0,17380753 ! osteoblast differentiation GO:0001649 63 26 0,000 0,14912017 0,17372464 ! neural crest cell development GO:0014032 59 26 0,000 0,14912017 0,17364184 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,14912017 0,17355911 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,14912017 0,17347646 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,14912017 0,1733939 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,14912017 0,17331141 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,14912017 0,17322899 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,14912017 0,17314666 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,14912017 0,17306441 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,14912017 0,17298223 ! telomere organization GO:0032200 46 26 0,000 0,14912017 0,17290013 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,14912017 0,17281811 ! alditol metabolic process GO:0019400 44 26 0,000 0,14912017 0,17273617 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,14912017 0,1726543 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,15439056 0,17867178 ! embryonic pattern specification GO:0009880 49 27 0,000 0,15439056 0,17858718 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,15439056 0,17850266 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,15439056 0,17841823 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,15439056 0,17833387 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,15439056 0,17824959 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,15439056 0,17816539 ! iron ion transport GO:0006826 65 27 0,000 0,15439056 0,17808127 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,15439056 0,17799723 ! superoxide metabolic process GO:0006801 41 27 0,000 0,15439056 0,17791327 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,15439056 0,17782939 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,15439056 0,17774558 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,15439056 0,17766186 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,15962844 0,18360277 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,15962844 0,18351637 ! vesicle docking GO:0048278 55 28 0,000 0,15962844 0,18343005 ! circadian rhythm GO:0007623 56 28 0,000 0,15962844 0,18334381 ! dendrite development GO:0016358 67 28 0,000 0,15962844 0,18325765 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,15962844 0,18317158 ! fat cell differentiation GO:0045444 57 28 0,000 0,15962844 0,18308558 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,15962844 0,18299967 ! sperm motility GO:0030317 37 28 0,000 0,15962844 0,18291383 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,15962844 0,18282808 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,15962844 0,1827424 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,15962844 0,18265681 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,15962844 0,1825713 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,15962844 0,18248586 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,15962844 0,18240051 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,15962844 0,18231524 ! glutathione metabolic process GO:0006749 42 28 0,000 0,15962844 0,18223004 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,15962844 0,18214493 ! lipid oxidation GO:0034440 48 28 0,000 0,15962844 0,18205989 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,15962844 0,18197494 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,16483403 0,18782162 ! translational initiation GO:0006413 66 29 0,000 0,16483403 0,18773405 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,16483403 0,18764657 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,16483403 0,18755917 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,16483403 0,18747186 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,16483403 0,18738462 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,16483403 0,18729746 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,16483403 0,18721039 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,16483403 0,1871234 ! synaptogenesis GO:0007416 46 29 0,000 0,16483403 0,18703648 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,16483403 0,18694965 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,16483403 0,1868629 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,16483403 0,18677623 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,17000752 0,19254909 ! phenol metabolic process GO:0018958 56 30 0,000 0,17000752 0,19245986 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,17000752 0,19237072 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,17000752 0,19228166 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,17000752 0,19219268 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,17000752 0,19210379 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,17000752 0,19201497 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,17000752 0,19192624 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,17000752 0,19183759 ! myofibril assembly GO:0030239 50 30 0,000 0,17000752 0,19174902 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,17000752 0,19166054 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,17000752 0,19157213 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,17000752 0,19148381 ! phospholipid transport GO:0015914 65 30 0,000 0,17000752 0,19139557 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,17000752 0,19130741 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,17000752 0,19121933 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,17000752 0,19113133 ! regulation of coagulation GO:0050818 52 30 0,000 0,17000752 0,19104341 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,17514911 0,1967307 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,17514911 0,1966403 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,17514911 0,19654997 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,17514911 0,19645973 ! regulation of innate immune response GO:0045088 57 31 0,000 0,17514911 0,19636956 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,17514911 0,19627949 ! detection of light stimulus GO:0009583 44 31 0,000 0,17514911 0,19618949 ! natural killer cell activation GO:0030101 50 31 0,000 0,17514911 0,19609958 ! cofactor catabolic process GO:0051187 54 31 0,000 0,17514911 0,19600975 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,17514911 0,19592 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,17514911 0,19583033 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,18025899 0,20145138 ! collagen metabolic process GO:0032963 49 32 0,000 0,18025899 0,20135927 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,18025899 0,20126724 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,18025899 0,20117529 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,18025899 0,20108343 ! muscle cell development GO:0055001 52 32 0,000 0,18025899 0,20099166 ! mesoderm formation GO:0001707 73 32 0,000 0,18025899 0,20089996 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,18025899 0,20080835 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,18025899 0,20071683 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,18025899 0,20062539 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,18533736 0,2061836 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,18533736 0,20608975 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,18533736 0,20599598 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,18533736 0,20590231 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,18533736 0,20580872 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,18533736 0,20571521 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,18533736 0,20562179 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,18533736 0,20552845 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,19038441 0,21102954 ! cholesterol transport GO:0030301 62 34 0,000 0,19038441 0,21093384 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,19038441 0,21083822 ! spliceosome assembly GO:0000245 75 34 0,000 0,19038441 0,21074269 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,19038441 0,21064725 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,19038441 0,21055189 ! formation of primary germ layer GO:0001704 76 34 0,000 0,19038441 0,21045661 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,19038441 0,21036143 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,19038441 0,21026633 ! adult locomotory behavior GO:0008344 62 34 0,000 0,19038441 0,21017131 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,19540033 0,21561112 ! negative regulation of secretion GO:0051048 68 35 0,000 0,19540033 0,21551378 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,19540033 0,21541652 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,19540033 0,21531936 ! membrane docking GO:0022406 69 35 0,000 0,19540033 0,21522228 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,19540033 0,21512529 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,19540033 0,21502839 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,19540033 0,21493157 ! ceramide metabolic process GO:0006672 72 35 0,000 0,19540033 0,21483484 ! sterol transport GO:0015918 63 35 0,000 0,19540033 0,2147382 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,19540033 0,21464164 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,19540033 0,21454518 ! placenta development GO:0001890 53 35 0,000 0,19540033 0,21444879 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,20038532 0,21982099 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,20038532 0,21972233 ! regulation of proteolysis GO:0030162 77 36 0,000 0,20038532 0,21962375 ! aerobic respiration GO:0009060 56 36 0,000 0,20038532 0,21952527 ! cytokine production GO:0001816 68 36 0,000 0,20038532 0,21942687 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,20038532 0,21932856 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,20038532 0,21923034 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,20533956 0,22454994 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! tissue remodeling GO:0048771 78 37 0,000 0,20533956 0,22444947 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,20533956 0,22434909 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,20533956 0,2242488 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,21026325 0,22952329 ! organic anion transport GO:0015711 82 38 0,000 0,21026325 0,22942078 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,21026325 0,22931836 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,21026325 0,22921603 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,21026325 0,22911379 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,21026325 0,22901164 ! spermatid development GO:0007286 69 38 0,000 0,21026325 0,22890959 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,21515657 0,23413251 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,21515657 0,23402827 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,21515657 0,23392412 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,21515657 0,23382006 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,21515657 0,23371609 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,2200197 0,2388925 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,2200197 0,23878637 ! learning GO:0007612 82 40 0,000 0,2200197 0,23868034 ! lipid homeostasis GO:0055088 75 40 0,000 0,2200197 0,2385744 ! mismatch repair GO:0006298 58 40 0,000 0,2200197 0,23846856 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,2200197 0,23836281 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,2200197 0,23825715 ! RNA export from nucleus GO:0006405 61 41 0,000 0,22485284 0,24338302 ! mRNA catabolic process GO:0006402 79 41 0,000 0,22485284 0,24327523 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,22485284 0,24316754 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,22485284 0,24305995 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,22485284 0,24295244 ! feeding behavior GO:0007631 69 41 0,000 0,22485284 0,24284504 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,22485284 0,24273773 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,22485284 0,24263051 ! spermatid differentiation GO:0048515 73 41 0,000 0,22485284 0,24252339 ! RNA modification GO:0009451 64 41 0,000 0,22485284 0,24241636 ! organic ether metabolic process GO:0018904 59 42 0,000 0,22965616 0,24748566 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,22965616 0,24737654 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,22965616 0,24726752 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,22965616 0,24715859 ! regulation of protein secretion GO:0050708 77 42 0,000 0,22965616 0,24704976 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,23442985 0,252074 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,23442985 0,2519631 ! regulation of tube size GO:0035150 76 43 0,000 0,23442985 0,2518523 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,23442985 0,25174159 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,23442985 0,25163099 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,23442985 0,25152048 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,23442985 0,25141006 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,23442985 0,25129975 ! ion transmembrane transport GO:0034220 79 43 0,000 0,23442985 0,25118953 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,2391741 0,25616059 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,2391741 0,25604834 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,2391741 0,25593619 ! striated muscle contraction GO:0006941 85 44 0,000 0,2391741 0,25582413 ! phagocytosis GO:0006909 105 44 0,000 0,2391741 0,25571217 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,2391741 0,25560031 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,24388907 0,26052515 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,24388907 0,26041128 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,24388907 0,26029751 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,24388907 0,26018385 ! polyol metabolic process GO:0019751 77 45 0,000 0,24388907 0,26007028 ! maintenance of location in cell GO:0051651 101 45 0,000 0,24388907 0,25995681 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,24857496 0,26483586 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,24857496 0,26472042 ! glycolysis GO:0006096 71 46 0,000 0,24857496 0,26460507 ! leukocyte migration GO:0050900 75 46 0,000 0,24857496 0,26448982 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,24857496 0,26437468 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,24857496 0,26425963 ! cell growth GO:0016049 90 46 0,000 0,24857496 0,26414469 ! positive regulation of defense response GO:0031349 88 48 0,000 0,25786019 0,27389237 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,25786019 0,27377334 ! endosome transport GO:0016197 127 48 0,000 0,25786019 0,27365441 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,25786019 0,27353559 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,25786019 0,27341686 ! response to calcium ion GO:0051592 94 49 0,000 0,26245989 0,27817332 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,26245989 0,27805269 ! regulation of ion transport GO:0043269 86 50 0,000 0,2670312 0,28277296 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,2670312 0,28265045 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,2670312 0,28252803 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,2670312 0,28240573 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,2670312 0,28228353 ! viral infectious cycle GO:0019058 104 51 0,000 0,27157431 0,28696196 ! peptide metabolic process GO:0006518 80 51 0,000 0,27157431 0,28683789 ! Notch signaling pathway GO:0007219 111 52 0,000 0,27608939 0,29148072 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,27608939 0,29135481 ! excretion GO:0007588 87 52 0,000 0,27608939 0,29122901 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,27608939 0,29110332 ! amino acid activation GO:0043038 98 52 0,000 0,27608939 0,29097773 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,28057661 0,29557941 ! inner ear development GO:0048839 89 53 0,000 0,28057661 0,29545201 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,28057661 0,29532471 ! cartilage development GO:0051216 99 53 0,000 0,28057661 0,29519753 ! regulation of translational initiation GO:0006446 87 54 0,000 0,28503614 0,29976035 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,28503614 0,29963136 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,28503614 0,29950249 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,28503614 0,29937372 ! membrane fusion GO:0006944 122 54 0,000 0,28503614 0,29924507 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,28503614 0,29911653 ! RNA catabolic process GO:0006401 103 55 0,000 0,28946815 0,30363705 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,28946815 0,30350673 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,28946815 0,30337653 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,28946815 0,30324643 ! cell recognition GO:0008037 98 55 0,000 0,28946815 0,30311645 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,28946815 0,30298658 ! glucose catabolic process GO:0006007 88 56 0,000 0,29387281 0,30746521 ! chloride transport GO:0006821 102 57 0,000 0,29825029 0,31191158 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,29825029 0,31177811 ! regulation of actin filament length GO:0030832 118 58 0,000 0,30260075 0,31619061 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,30260075 0,31605542 ! gastrulation GO:0007369 122 58 0,000 0,30260075 0,31592036 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,30260075 0,31578541 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,30260075 0,31565057 ! maintenance of location GO:0051235 124 58 0,000 0,30260075 0,31551585 ! nuclear export GO:0051168 110 59 0,000 0,30692437 0,31988747 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,3112213 0,32422756 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,3112213 0,32408936 ! adult behavior GO:0030534 104 60 0,000 0,3112213 0,32395127 ! positive regulation of secretion GO:0051047 110 61 0,000 0,31549171 0,3282565 ! regulation of cellular component size GO:0032535 125 61 0,000 0,31549171 0,32811675 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,31549171 0,32797713 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,31549171 0,32783762 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,31549171 0,32769824 ! regulation of heart contraction GO:0008016 123 61 0,000 0,31549171 0,32755897 ! proton transport GO:0015992 117 61 0,000 0,31549171 0,32741982 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,31549171 0,32728079 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,31973577 0,33154265 ! tRNA processing GO:0008033 102 62 0,000 0,31973577 0,33140199 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,32395363 0,33563135 ! mesoderm development GO:0007498 128 63 0,000 0,32395363 0,33548907 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,32395363 0,33534691 ! hydrogen transport GO:0006818 121 64 0,000 0,32814546 0,33954229 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,32814546 0,33939854 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,33231141 0,3435619 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,33231141 0,34341657 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,33231141 0,34327136 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,33645165 0,34740126 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,34056633 0,35150128 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,34465561 0,35557164 ! hexose catabolic process GO:0019320 113 68 0,000 0,34465561 0,35542155 ! extracellular matrix organization GO:0030198 146 68 0,000 0,34465561 0,35527158 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,34465561 0,35512174 ! regulation of lipase activity GO:0060191 137 68 0,000 0,34465561 0,35497203 ! adaptive immune response GO:0002250 126 68 0,000 0,34465561 0,35482244 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,34871964 0,35885513 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,34871964 0,35870404 ! single fertilization GO:0007338 83 69 0,000 0,34871964 0,35855307 ! cell redox homeostasis GO:0045454 114 70 0,000 0,35275859 0,36255332 ! activation of immune response GO:0002253 120 70 0,000 0,35275859 0,36240086 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,35275859 0,36224852 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,35677261 0,36621659 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,35677261 0,36606278 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,36076184 0,37000049 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,36076184 0,36984522 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,36472644 0,37375281 ! regulation of immune effector process GO:0002697 156 73 0,000 0,36472644 0,3735961 ! amino acid transport GO:0006865 148 74 0,000 0,36866657 0,37747377 ! transition metal ion transport GO:0000041 143 75 0,000 0,37258236 0,3813233 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,37258236 0,38116362 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,37647398 0,38498365 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,37647398 0,38482257 ! amine catabolic process GO:0009310 136 77 0,000 0,38034158 0,38861333 ! neurotransmitter transport GO:0006836 142 77 0,000 0,38034158 0,38845086 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,38034158 0,38828854 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,38034158 0,38812634 ! antigen processing and presentation GO:0019882 117 78 0,000 0,38418528 0,39188503 ! fertilization GO:0009566 99 78 0,000 0,38418528 0,39172147 ! blood coagulation GO:0007596 151 79 0,000 0,38800526 0,39545133 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,38800526 0,39528643 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,38800526 0,39512165 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,38800526 0,39495702 ! muscle cell differentiation GO:0042692 178 81 0,000 0,39557459 0,40249426 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,40305072 0,40993044 ! exocytosis GO:0006887 153 83 0,000 0,40305072 0,40975984 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,40305072 0,40958939 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,40305072 0,40941909 ! digestion GO:0007586 130 84 0,000 0,40675419 0,41300935 ! hemostasis GO:0007599 165 85 0,000 0,41043479 0,41657341 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,41043479 0,41640041 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,41043479 0,41622756 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,41043479 0,41605485 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,41409266 0,4195887 ! regulation of lyase activity GO:0051339 169 86 0,000 0,41409266 0,41941475 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,41772794 0,4229214 ! alcohol catabolic process GO:0046164 142 87 0,000 0,41772794 0,42274621 ! nucleosome assembly GO:0006334 126 87 0,000 0,41772794 0,42257116 ! cellular respiration GO:0045333 143 88 0,000 0,42134076 0,42604945 ! amine biosynthetic process GO:0009309 146 88 0,000 0,42134076 0,42587318 ! sensory perception of smell GO:0007608 117 88 0,000 0,42134076 0,42569705 ! chromatin assembly GO:0031497 128 88 0,000 0,42134076 0,42552107 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,42493127 0,42896987 ! cellular defense response GO:0006968 123 89 0,000 0,42493127 0,42879268 ! regulation of neurological system process GO:0031644 175 89 0,000 0,42493127 0,42861564 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,42849959 0,43203653 ! response to unfolded protein GO:0006986 139 90 0,000 0,42849959 0,4318583 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,43204588 0,43525282 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,43204588 0,43507341 ! defense response to bacterium GO:0042742 112 91 0,000 0,43204588 0,43489415 ! bone development GO:0060348 206 92 0,000 0,43557026 0,43826118 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,43557026 0,43808076 ! amine transport GO:0015837 181 93 0,000 0,43907287 0,44142182 ! vitamin metabolic process GO:0006766 153 93 0,000 0,43907287 0,44124024 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,44255385 0,44455553 ! sterol metabolic process GO:0016125 166 94 0,000 0,44255385 0,44437281 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,44255385 0,44419024 ! nucleosome organization GO:0034728 143 95 0,000 0,44601332 0,44747866 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,44601332 0,44729496 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,44601332 0,44711142 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,44601332 0,44692803 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,44601332 0,44674479 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,45286827 0,45342507 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,45626401 0,45663785 ! mRNA transport GO:0051028 185 100 0,000 0,46299269 0,46318229 ! positive regulation of immune response GO:0050778 175 100 0,000 0,46299269 0,46299269