pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6473-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of apoptosis by intracellular signals GO:0008629 67 40 8,000 4,529E-12 1,042E-08 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 1,006E-07 1,157E-04 ! negative regulation of kinase activity GO:0033673 100 58 6,000 1,138E-07 8,724E-05 ! negative regulation of transferase activity GO:0051348 105 61 6,000 1,624E-07 9,339E-05 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 5,000 1,113E-06 5,118E-04 ! interphase of mitotic cell cycle GO:0051329 156 86 6,000 1,743E-06 6,681E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 1,811E-06 5,951E-04 ! interphase GO:0051325 159 88 6,000 2,037E-06 5,856E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 5,423E-06 1,386E-03 ! ER overload response GO:0006983 7 6 2,000 5,758E-06 1,324E-03 ! positive regulation of locomotion GO:0040017 35 20 3,000 8,498E-06 1,777E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 9,68E-06 1,855E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,003E-05 1,774E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,003E-05 1,647E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 3,000 1,044E-05 1,601E-03 ! regulation of chemotaxis GO:0050920 36 21 3,000 1,044E-05 1,501E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 3,000 1,044E-05 1,413E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 1,27E-05 1,623E-03 ! regulation of behavior GO:0050795 38 22 3,000 1,27E-05 1,537E-03 ! response to UV GO:0009411 75 46 4,000 1,357E-05 1,56E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 3,000 1,529E-05 1,675E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 3,000 1,529E-05 1,599E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 1,529E-05 1,529E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 1,597E-05 1,53E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,597E-05 1,469E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 1,826E-05 1,615E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 2,162E-05 1,842E-03 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of cell migration GO:0030335 92 51 4,000 2,264E-05 1,859E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 2,383E-05 1,89E-03 ! cell cycle arrest GO:0007050 150 86 5,000 2,401E-05 1,841E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 3,388E-05 2,514E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 3,584E-05 2,576E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 4,636E-05 3,231E-03 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 4,636E-05 3,136E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 4,636E-05 3,046E-03 GO:0010829|negative regulation of glucose transport, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 6,354E-05 4,059E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 7,567E-05 4,704E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 7,957E-05 4,816E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 1,054E-04 6,216E-03 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 3,000 1,18E-04 6,784E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 1,206E-04 6,764E-03 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,254E-04 6,865E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,308E-04 6,996E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 1,446E-04 7,557E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,535E-04 7,847E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 1,855E-04 9,276E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1,855E-04 9,079E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 1,922E-04 9,211E-03 ! positive regulation of DNA replication GO:0045740 29 18 2,000 2,215E-04 0,01039883 ! regulation of glucose import GO:0046324 21 18 2,000 2,215E-04 0,01019085 GO:0010827|regulation of glucose transport, ! positive regulation of cell cycle GO:0045787 77 45 3,000 2,297E-04 0,01035964 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 2,297E-04 0,01016041 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 2,618E-04 0,01136103 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 2,618E-04 0,01115064 ! cellular response to reactive oxygen species GO:0034614 27 19 2,000 2,618E-04 0,0109479 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 2,638E-04 0,01083477 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 2,638E-04 0,01064469 ! regulation of DNA replication GO:0006275 75 48 3,000 2,954E-04 0,01171404 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 3,065E-04 0,01194821 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 3,065E-04 0,01174907 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 3,558E-04 0,01341691 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 4,1E-04 0,01521042 ! protein tetramerization GO:0051262 39 22 2,000 4,1E-04 0,01496898 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 4,383E-04 0,01575108 ! positive regulation of glycolysis GO:0045821 11 5 1,000 4,383E-04 0,01550875 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 4,383E-04 0,01527377 ! monocyte differentiation GO:0030224 8 5 1,000 4,383E-04 0,01504581 ! regulation of respiratory burst GO:0060263 8 5 1,000 4,383E-04 0,01482454 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 4,383E-04 0,0146097 ! response to light stimulus GO:0009416 153 96 4,000 4,637E-04 0,01523681 ! myelination GO:0042552 35 23 2,000 4,692E-04 0,01520038 ! cellular response to oxidative stress GO:0034599 33 23 2,000 4,692E-04 0,01498926 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 5,351E-04 0,01685998 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 5,726E-04 0,01779573 ! regulation of chromosome organization GO:0033044 35 25 2,000 6,035E-04 0,0185066 ! regulation of helicase activity GO:0051095 11 6 1,000 6,546E-04 0,01980897 ! male meiosis GO:0007140 7 6 1,000 6,546E-04 0,01955171 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 6,546E-04 0,01930105 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 6,546E-04 0,01905673 ! activation of MAPKKK activity GO:0000185 10 6 1,000 6,546E-04 0,01881852 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 6,546E-04 0,01858619 ! male sex determination GO:0030238 9 6 1,000 6,546E-04 0,01835953 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 1,000 6,546E-04 0,01813833 ! coenzyme A metabolic process GO:0015936 9 6 1,000 6,546E-04 0,0179224 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 6,546E-04 0,01771155 ! negative regulation of protein modification process GO:0031400 50 26 2,000 6,789E-04 0,01815594 ! cell junction assembly GO:0034329 56 28 2,000 8,471E-04 0,02239433 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 8,471E-04 0,02213985 ! ensheathment of neurons GO:0007272 43 28 2,000 8,471E-04 0,02189109 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 2,000 8,471E-04 0,02164785 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 8,885E-04 0,0224554 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 9,124E-04 0,02280923 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 9,124E-04 0,02256397 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 9,124E-04 0,02232392 ! microtubule bundle formation GO:0001578 8 7 1,000 9,124E-04 0,02208893 ! protein heterooligomerization GO:0051291 10 7 1,000 9,124E-04 0,02185884 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 9,124E-04 0,02163349 ! B cell lineage commitment GO:0002326 17 7 1,000 9,124E-04 0,02141274 ! T cell lineage commitment GO:0002360 12 7 1,000 9,124E-04 0,02119645 ! response to tumor cell GO:0002347 12 7 1,000 9,124E-04 0,02098449 ! ATP catabolic process GO:0006200 10 7 1,000 9,124E-04 0,02077672 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 1,000 9,124E-04 0,02057303 ! regulation of caspase activity GO:0043281 97 65 3,000 9,419E-04 0,021032 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,04E-03 0,02299208 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 1,055E-03 0,02311853 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,145E-03 0,024854 GO:0060326|cell chemotaxis, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,211E-03 0,0260345 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,211E-03 0,02579344 ! Golgi to endosome transport GO:0006895 16 8 1,000 1,211E-03 0,0255568 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,211E-03 0,02532447 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,211E-03 0,02509632 ! keratinocyte proliferation GO:0043616 12 8 1,000 1,211E-03 0,02487224 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,211E-03 0,02465214 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 1,000 1,211E-03 0,02443589 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,211E-03 0,0242234 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,211E-03 0,02401458 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,211E-03 0,02380933 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 1,000 1,211E-03 0,02360755 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,211E-03 0,02340917 ! regulation of embryonic development GO:0045995 16 8 1,000 1,211E-03 0,02321409 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 1,243E-03 0,02363219 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 1,377E-03 0,0259575 ! cell junction organization GO:0034330 63 33 2,000 1,377E-03 0,02574646 ! negative regulation of hydrolase activity GO:0051346 50 33 2,000 1,377E-03 0,02553883 ! cytokinesis GO:0000910 52 33 2,000 1,377E-03 0,02533452 ! regulation of peptidase activity GO:0052547 106 72 3,000 1,381E-03 0,02520434 ! mitochondrion organization GO:0007005 104 73 3,000 1,453E-03 0,02632033 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 1,529E-03 0,02746594 ! regulation of developmental growth GO:0048638 13 9 1,000 1,55E-03 0,02764296 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,55E-03 0,02743033 ! regulation of glycolysis GO:0006110 15 9 1,000 1,55E-03 0,02722093 ! substrate-bound cell migration GO:0006929 10 9 1,000 1,55E-03 0,02701471 ! motor axon guidance GO:0008045 14 9 1,000 1,55E-03 0,0268116 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 1,000 1,55E-03 0,02661151 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 1,55E-03 0,02641439 ! localization within membrane GO:0051668 15 9 1,000 1,55E-03 0,02622016 ! regulation of action potential in neuron GO:0019228 54 35 2,000 1,636E-03 0,02746096 ! response to reactive oxygen species GO:0000302 55 36 2,000 1,776E-03 0,0295962 ! positive regulation of protein modification process GO:0031401 107 78 3,000 1,857E-03 0,03071934 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,93E-03 0,03169963 ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 1,93E-03 0,03147481 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,93E-03 0,03125315 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,93E-03 0,0310346 ! response to X-ray GO:0010165 16 10 1,000 1,93E-03 0,03081908 ! embryonic axis specification GO:0000578 12 10 1,000 1,93E-03 0,03060653 ! purine ribonucleotide catabolic process GO:0009154 14 10 1,000 1,93E-03 0,0303969 ! DNA methylation GO:0006306 15 10 1,000 1,93E-03 0,03019012 GO:0006305|DNA alkylation, ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,93E-03 0,02998613 GO:0043470|regulation of carbohydrate catabolic process, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 1,93E-03 0,02978488 ! virus-host interaction GO:0019048 17 11 1,000 2,348E-03 0,0360031 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 2,348E-03 0,03576467 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,348E-03 0,03552937 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 2,348E-03 0,03529716 ! ribonucleotide catabolic process GO:0009261 16 11 1,000 2,348E-03 0,03506795 ! focal adhesion formation GO:0048041 24 11 1,000 2,348E-03 0,03484171 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,348E-03 0,03461837 ! nucleoside triphosphate catabolic process GO:0009143 15 11 1,000 2,348E-03 0,03439787 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 2,348E-03 0,03418016 GO:0042130|negative regulation of T cell proliferation, ! actin filament polymerization GO:0030041 17 11 1,000 2,348E-03 0,03396519 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 2,435E-03 0,03500878 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 2,805E-03 0,04007618 ! positive regulation of cell growth GO:0030307 16 12 1,000 2,805E-03 0,0398288 ! cell-cell junction assembly GO:0007043 18 12 1,000 2,805E-03 0,03958445 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 2,805E-03 0,03934308 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 2,805E-03 0,03910464 ! peptidyl-lysine modification GO:0018205 18 12 1,000 2,805E-03 0,03886907 ! response to gamma radiation GO:0010332 20 12 1,000 2,805E-03 0,03863632 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,805E-03 0,03840634 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 2,967E-03 0,04037653 ! leukocyte migration GO:0050900 60 43 2,000 2,967E-03 0,04013902 ! activation of caspase activity GO:0006919 65 43 2,000 2,967E-03 0,03990429 ! regulation of action potential GO:0001508 71 44 2,000 3,168E-03 0,0423693 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 3,168E-03 0,04212439 ! regulation of inflammatory response GO:0050727 60 44 2,000 3,168E-03 0,04188229 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 3,168E-03 0,04164296 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 3,301E-03 0,0431371 ! endocrine pancreas development GO:0031018 19 13 1,000 3,301E-03 0,04289339 ! regulation of cellular pH GO:0030641 20 13 1,000 3,301E-03 0,04265242 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 3,301E-03 0,04241413 ! positive regulation of defense response GO:0031349 59 45 2,000 3,378E-03 0,04316843 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 3,52E-03 0,04472574 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 3,823E-03 0,0483165 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 3,834E-03 0,04819046 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 3,834E-03 0,04792856 ! activation of MAPKK activity GO:0000186 21 14 1,000 3,834E-03 0,04766948 ! cellular response to starvation GO:0009267 21 14 1,000 3,834E-03 0,0474132 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 3,834E-03 0,04715965 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of caspase activity GO:0043154 20 14 1,000 3,834E-03 0,0469088 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 3,834E-03 0,04666061 ! G1/S transition checkpoint GO:0031575 33 14 1,000 3,834E-03 0,04641502 ! negative regulation of blood coagulation GO:0030195 19 14 1,000 3,834E-03 0,04617201 ! regulation of response to external stimulus GO:0032101 139 96 3,000 3,944E-03 0,04724335 ! positive regulation of caspase activity GO:0043280 72 48 2,000 4,058E-03 0,04836554 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 4,058E-03 0,04811624 ! cartilage development GO:0051216 70 49 2,000 4,302E-03 0,05074525 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 4,401E-03 0,05164678 ! positive regulation of cell size GO:0045793 20 15 1,000 4,405E-03 0,05142764 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 4,405E-03 0,05116791 ! skin development GO:0043588 25 15 1,000 4,405E-03 0,05091078 ! lipid phosphorylation GO:0046834 23 15 1,000 4,405E-03 0,05065623 ! centrosome cycle GO:0007098 16 15 1,000 4,405E-03 0,05040421 ! regulation of survival gene product expression GO:0045884 20 15 1,000 4,405E-03 0,05015468 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 4,405E-03 0,04990761 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 4,405E-03 0,04966297 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 4,405E-03 0,04942071 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 4,405E-03 0,0491808 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 4,405E-03 0,04894321 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 4,405E-03 0,04870791 ! positive regulation of growth GO:0045927 67 50 2,000 4,555E-03 0,05012506 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 5,012E-03 0,05489581 ! protein amino acid acetylation GO:0006473 28 16 1,000 5,012E-03 0,05463564 ! cellular response to unfolded protein GO:0034620 19 16 1,000 5,012E-03 0,05437793 GO:0030968|endoplasmic reticulum unfolded protein response, ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 5,012E-03 0,05412263 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 5,012E-03 0,05386972 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 5,012E-03 0,05361917 ! signal complex assembly GO:0007172 29 17 1,000 5,656E-03 0,06022366 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 5,656E-03 0,05994613 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 5,656E-03 0,05967115 ! cell-substrate junction assembly GO:0007044 39 17 1,000 5,656E-03 0,05939868 ! actin polymerization or depolymerization GO:0008154 31 17 1,000 5,656E-03 0,05912868 ! actin filament bundle formation GO:0051017 26 17 1,000 5,656E-03 0,05886113 ! neuromuscular junction development GO:0007528 23 17 1,000 5,656E-03 0,05859599 ! peptidyl-serine modification GO:0018209 27 17 1,000 5,656E-03 0,05833323 ! cell-cell junction organization GO:0045216 25 17 1,000 5,656E-03 0,05807281 ! negative regulation of coagulation GO:0050819 23 17 1,000 5,656E-03 0,05781471 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 6,258E-03 0,06368509 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 6,335E-03 0,06418791 ! axis specification GO:0009798 26 18 1,000 6,335E-03 0,06390639 ! pancreas development GO:0031016 26 18 1,000 6,335E-03 0,06362732 ! somitogenesis GO:0001756 24 18 1,000 6,335E-03 0,06335068 ! cellular response to nutrient levels GO:0031669 27 18 1,000 6,335E-03 0,06307643 ! purine nucleotide catabolic process GO:0006195 26 18 1,000 6,335E-03 0,06280455 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 6,335E-03 0,06253501 ! negative regulation of T cell activation GO:0050868 25 18 1,000 6,335E-03 0,06226776 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 6,335E-03 0,06200279 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 7,05E-03 0,06870344 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 32 19 1,000 7,05E-03 0,06841355 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 7,05E-03 0,0681261 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 7,05E-03 0,06784105 ! apoptotic nuclear changes GO:0030262 24 19 1,000 7,05E-03 0,06755838 ! response to starvation GO:0042594 30 19 1,000 7,05E-03 0,06727806 ! sex determination GO:0007530 29 19 1,000 7,05E-03 0,06700005 ! plasma membrane fusion GO:0045026 23 19 1,000 7,05E-03 0,06672433 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 7,05E-03 0,06645087 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 7,05E-03 0,06617964 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 7,05E-03 0,06591062 ! actin filament organization GO:0007015 95 59 2,000 7,233E-03 0,06735538 ! regulation of heart contraction GO:0008016 91 60 2,000 7,577E-03 0,07027478 ! DNA modification GO:0006304 28 20 1,000 7,799E-03 0,07203711 ! positive regulation of B cell activation GO:0050871 31 20 1,000 7,799E-03 0,07174897 ! meiosis GO:0007126 96 61 2,000 7,931E-03 0,07267507 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 7,931E-03 0,07238668 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 7,931E-03 0,07210057 ! negative regulation of cell growth GO:0030308 106 62 2,000 8,294E-03 0,07510554 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 8,294E-03 0,07481101 ! meiotic cell cycle GO:0051321 97 62 2,000 8,294E-03 0,07451878 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 8,582E-03 0,07680631 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 8,582E-03 0,07650861 ! protein amino acid acylation GO:0043543 37 21 1,000 8,582E-03 0,07621321 ! dendrite development GO:0016358 35 21 1,000 8,582E-03 0,07592008 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 8,582E-03 0,0756292 ! purine ribonucleoside metabolic process GO:0046128 28 21 1,000 8,582E-03 0,07534054 GO:0042278|purine nucleoside metabolic process, ! cell aging GO:0007569 32 21 1,000 8,582E-03 0,07505407 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 8,582E-03 0,07476978 ! platelet activation GO:0030168 28 21 1,000 8,582E-03 0,07448763 ! negative regulation of cell size GO:0045792 108 64 2,000 9,05E-03 0,07824906 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 9,399E-03 0,08096943 ! microtubule organizing center organization GO:0031023 28 22 1,000 9,399E-03 0,08066731 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 9,399E-03 0,08036743 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of blood coagulation GO:0030193 34 22 1,000 9,399E-03 0,08006977 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 9,442E-03 0,08013495 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 9,442E-03 0,07984034 ! activation of immune response GO:0002253 83 65 2,000 9,442E-03 0,07954788 ! protein oligomerization GO:0051259 100 65 2,000 9,442E-03 0,07925756 ! cell-substrate adhesion GO:0031589 121 66 2,000 9,844E-03 0,08233252 ! embryonic pattern specification GO:0009880 31 23 1,000 0,01025 0,08541664 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01025 0,08510828 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01025 0,08480213 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01025 0,08449818 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01025 0,0841964 ! interaction with host GO:0051701 37 23 1,000 0,01025 0,08389677 ! group transfer coenzyme metabolic process GO:0006752 28 23 1,000 0,01025 0,08359926 ! response to drug GO:0042493 108 69 2,000 0,01110975 0,09029123 ! positive regulation of ligase activity GO:0051351 99 69 2,000 0,01110975 0,0899733 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,0111333 0,08984769 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,0111333 0,08953354 ! fat cell differentiation GO:0045444 37 24 1,000 0,0111333 0,08922157 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,0111333 0,08891178 ! negative regulation of cell development GO:0010721 56 24 1,000 0,0111333 0,08860412 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,0111333 0,08829859 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,0111333 0,08799516 ! glutathione metabolic process GO:0006749 29 24 1,000 0,0111333 0,08769381 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,01200333 0,09422409 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01204894 0,0942604 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01204894 0,09394087 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01204894 0,0936235 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01204894 0,09330827 ! response to hypoxia GO:0001666 132 72 2,000 0,01246518 0,09620777 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01246518 0,095886 ! negative regulation of transport GO:0051051 116 73 2,000 0,01293712 0,09918456 ! regulation of pH GO:0006885 36 26 1,000 0,01299644 0,09930837 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01299644 0,09897953 ! regulation of coagulation GO:0050818 39 26 1,000 0,01299644 0,09865287 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01299644 0,09832835 ! response to oxygen levels GO:0070482 137 74 2,000 0,01341917 0,10119373 ! protein import into nucleus GO:0006606 118 74 2,000 0,01341917 0,10086303 ! negative regulation of growth GO:0045926 123 75 2,000 0,01391137 0,10422197 ! regulation of ligase activity GO:0051340 114 75 2,000 0,01391137 0,10388358 ! nuclear import GO:0051170 121 75 2,000 0,01391137 0,10354739 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01397536 0,10368813 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01397536 0,10335473 ! complement activation, classical pathway GO:0006958 36 28 1,000 0,01498522 0,11046799 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,01498522 0,11011506 GO:0002764|immune response-regulating signal transduction, ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01498522 0,10976437 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01498522 0,10941592 ! protein localization in nucleus GO:0034504 133 80 2,000 0,01652543 0,12028005 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,01652543 0,11990061 GO:0010498|proteasomal protein catabolic process, ! spindle organization GO:0007051 37 30 1,000 0,01709602 0,12365044 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,01709602 0,12326282 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01709602 0,12287762 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,01819606 0,13037673 ! mammary gland development GO:0030879 57 31 1,000 0,01819606 0,12997183 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,01819606 0,12956944 ! segmentation GO:0035282 41 31 1,000 0,01819606 0,12916954 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01819606 0,12877209 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01819606 0,12837709 ! regulation of defense response GO:0031347 117 84 2,000 0,01880157 0,13224349 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,01932527 0,13551259 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,01932527 0,1351007 ! meiosis I GO:0007127 52 32 1,000 0,01932527 0,1346913 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01932527 0,13428438 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01932527 0,13387991 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01932527 0,13347786 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01932527 0,13307823 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,01939641 0,13316941 ! regulation of membrane potential GO:0042391 128 85 2,000 0,01939641 0,13277307 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02048323 0,13979656 ! ear morphogenesis GO:0042471 42 33 1,000 0,02048323 0,13938296 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02048323 0,1389718 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 1,000 0,02048323 0,13856306 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,02048323 0,13815671 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02061712 0,13865318 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,02061712 0,13824894 ! protein processing GO:0016485 114 88 2,000 0,02124301 0,14203174 ! feeding behavior GO:0007631 45 34 1,000 0,02166951 0,14446341 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02166951 0,14404589 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02166951 0,14363077 ! leukocyte differentiation GO:0002521 143 90 2,000 0,02252585 0,14887776 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,02252585 0,14845118 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,02288368 0,15037848 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,02288368 0,14995005 ! glycogen metabolic process GO:0005977 48 35 1,000 0,02288368 0,14952405 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02288368 0,14910047 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of immune response GO:0050778 121 92 2,000 0,02385014 0,15495853 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,02412532 0,15630491 GO:0090047|positive regulation of transcription regulator activity, ! glucan metabolic process GO:0044042 49 36 1,000 0,02412532 0,15586585 GO:0006073|cellular glucan metabolic process, ! response to oxidative stress GO:0006979 141 94 2,000 0,02521585 0,16245508 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,02539402 0,16314595 GO:0006956|complement activation, ! learning GO:0007612 67 37 1,000 0,02539402 0,1626915 ! ribonucleoside metabolic process GO:0009119 48 37 1,000 0,02539402 0,16223958 ! amino acid activation GO:0043038 52 37 1,000 0,02539402 0,16179017 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,02662296 0,1691514 ! protein maturation GO:0051604 129 96 2,000 0,02662296 0,16868542 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,02668937 0,1686416 ! pigmentation GO:0043473 74 38 1,000 0,02668937 0,16817957 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,02801095 0,17602509 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,02801095 0,17554546 ! cell growth GO:0016049 61 39 1,000 0,02801095 0,17506844 ! synapse organization GO:0050808 55 39 1,000 0,02801095 0,174594 ! protein import GO:0017038 156 99 2,000 0,02881109 0,17909598 ! response to calcium ion GO:0051592 58 40 1,000 0,02935837 0,18200606 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02935837 0,1815168 ! peptide metabolic process GO:0006518 56 40 1,000 0,02935837 0,18103016 ! T cell differentiation GO:0030217 65 40 1,000 0,02935837 0,18054612 ! double-strand break repair GO:0006302 67 40 1,000 0,02935837 0,18006467 ! B cell differentiation GO:0030183 62 40 1,000 0,02935837 0,17958577 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,02935837 0,17910942 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,02935837 0,17863558 ! protein localization in organelle GO:0033365 161 100 2,000 0,02956109 0,17939445 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,03073123 0,18600479 ! glucose transport GO:0015758 52 41 1,000 0,03073123 0,18551659 ! endosome transport GO:0016197 71 41 1,000 0,03073123 0,18503095 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,03073123 0,18454784 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,03073123 0,18406724 ! biopolymer methylation GO:0043414 62 41 1,000 0,03073123 0,18358915 ! mitochondrial transport GO:0006839 60 42 1,000 0,03212913 0,19144298 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,03212913 0,1909483 ! cellular component disassembly GO:0022411 64 42 1,000 0,03212913 0,19045616 ! hexose transport GO:0008645 54 42 1,000 0,03212913 0,18996656 GO:0015749|monosaccharide transport, ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,03212913 0,18947947 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,0330218 0,19424586 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,0330218 0,19375034 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,0330218 0,19325734 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,0330218 0,19276683 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,0330218 0,19227882 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0330218 0,19179326 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,0330218 0,19131016 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,0330218 0,19082948 ! sleep GO:0030431 11 5 0,000 0,0330218 0,19035121 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,0330218 0,18987533 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,0330218 0,18940183 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,0330218 0,18893068 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,0330218 0,18846187 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,0330218 0,18799538 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,0330218 0,18753119 ! tongue development GO:0043586 6 5 0,000 0,0330218 0,18706929 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,0330218 0,18660966 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,0330218 0,18615229 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,0330218 0,18569715 ! cobalt ion transport GO:0006824 9 5 0,000 0,0330218 0,18524423 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,0330218 0,18479351 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,0330218 0,18434498 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,0330218 0,18389863 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,0330218 0,18345443 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,0330218 0,18301237 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,0330218 0,18257243 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,0330218 0,18213461 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,0330218 0,18169888 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,0330218 0,18126523 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,0330218 0,18083365 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,0330218 0,18040412 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,0330218 0,17997662 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,0330218 0,17955114 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,0330218 0,17912767 ! malate metabolic process GO:0006108 7 5 0,000 0,0330218 0,1787062 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,0330218 0,1782867 ! behavioral response to pain GO:0048266 7 5 0,000 0,0330218 0,17786916 ! clathrin coat assembly GO:0048268 11 5 0,000 0,0330218 0,17745358 ! phototransduction, visible light GO:0007603 6 5 0,000 0,0330218 0,17703994 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0330218 0,17662822 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,0330218 0,17621841 ! mating behavior GO:0007617 6 5 0,000 0,0330218 0,17581049 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,0330218 0,17540446 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,0330218 0,17500031 ! rhythmic behavior GO:0007622 12 5 0,000 0,0330218 0,17459801 ! copulation GO:0007620 7 5 0,000 0,0330218 0,17419755 ! glial cell fate commitment GO:0021781 12 5 0,000 0,0330218 0,17379893 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,0330218 0,17340213 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,0330218 0,17300714 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,0330218 0,17261394 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,0330218 0,17222252 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,0330218 0,17183288 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,0330218 0,171445 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,0330218 0,17105886 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0330218 0,17067446 ! response to protozoan GO:0001562 9 5 0,000 0,0330218 0,17029178 ! lymph vessel development GO:0001945 7 5 0,000 0,0330218 0,16991081 ! endochondral ossification GO:0001958 12 5 0,000 0,0330218 0,16953155 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,0330218 0,16915397 ! parathyroid gland development GO:0060017 8 5 0,000 0,0330218 0,16877807 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,0330218 0,16840384 ! anagen GO:0042640 6 5 0,000 0,0330218 0,16803127 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,0330218 0,16766034 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,0330218 0,16729104 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,0330218 0,16692337 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,0330218 0,16655731 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,0330218 0,16619285 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,0330218 0,16582998 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,0330218 0,1654687 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,0330218 0,16510898 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,0330218 0,16475083 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,0330218 0,16439423 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,0330218 0,16403916 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,0330218 0,16368563 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,0330218 0,16333362 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,0330218 0,16298312 ! ovulation GO:0030728 6 5 0,000 0,0330218 0,16263412 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,0330218 0,16228661 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,0330218 0,16194058 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,0330218 0,16159603 ! response to pH GO:0009268 9 5 0,000 0,0330218 0,16125294 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,0330218 0,1609113 ! proline biosynthetic process GO:0006561 6 5 0,000 0,0330218 0,16057111 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,0330218 0,16023235 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,0330218 0,15989502 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,0330218 0,1595591 ! polyol catabolic process GO:0046174 7 5 0,000 0,0330218 0,1592246 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,0330218 0,15889149 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,0330218 0,15855978 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,0330218 0,15822944 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,0330218 0,15790048 ! nerve growth factor processing GO:0032455 7 5 0,000 0,0330218 0,15757289 ! urea metabolic process GO:0019627 6 5 0,000 0,0330218 0,15724665 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,0330218 0,15692176 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,0330218 0,15659821 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,0330218 0,15627599 ! neutrophil activation GO:0042119 5 5 0,000 0,0330218 0,1559551 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,0330218 0,15563552 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,0330218 0,15531725 ! response to food GO:0032094 5 5 0,000 0,0330218 0,15500027 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,0330218 0,15468459 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0330218 0,15437019 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,0330218 0,15405706 ! forebrain neuron development GO:0021884 7 5 0,000 0,0330218 0,15374521 ! melanosome organization GO:0032438 7 5 0,000 0,0330218 0,15343461 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,0330218 0,15312527 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,0330218 0,15281717 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,0330218 0,15251031 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0330218 0,15220468 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,0330218 0,15190027 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,0330218 0,15159707 ! nucleoside transport GO:0015858 6 5 0,000 0,0330218 0,15129509 ! nucleoside salvage GO:0043174 7 5 0,000 0,0330218 0,1509943 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,0330218 0,15069471 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0330218 0,1503963 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,0330218 0,15009908 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,0330218 0,14980302 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,0330218 0,14950814 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,0330218 0,14921441 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0330218 0,14892183 ! depyrimidination GO:0045008 8 5 0,000 0,0330218 0,1486304 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,0330218 0,1483401 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,0330218 0,14805094 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,0330218 0,1477629 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0330218 0,14747599 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,0330218 0,14719018 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,0330218 0,14690548 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,0330218 0,14662188 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,0330218 0,14633937 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,0330218 0,14605795 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,0330218 0,14577761 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0330218 0,14549834 ! centrosome duplication GO:0051298 5 5 0,000 0,0330218 0,14522014 ! response to UV-C GO:0010225 6 5 0,000 0,0330218 0,144943 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,0330218 0,14466692 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,0330218 0,14439189 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,0330218 0,1441179 ! regulation of dendrite development GO:0050773 12 5 0,000 0,0330218 0,14384495 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,0330218 0,14357303 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0330218 0,14330214 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,0330218 0,14303227 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,0330218 0,14276341 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,0330218 0,14249556 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,0330218 0,14222871 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,0330218 0,14196287 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,0330218 0,14169801 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,0330218 0,14143414 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,0330218 0,14117125 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,0330218 0,14090934 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,0330218 0,14064839 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,0330218 0,14038842 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,0330218 0,1401294 ! neural tube patterning GO:0021532 6 5 0,000 0,0330218 0,13987133 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,0330218 0,13961421 ! histone demethylation GO:0016577 9 5 0,000 0,0330218 0,13935804 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,0330218 0,13910281 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0330218 0,13884851 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,0330218 0,13859513 ! enteric nervous system development GO:0048484 8 5 0,000 0,0330218 0,13834268 ! establishment of planar polarity GO:0001736 6 5 0,000 0,0330218 0,13809115 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,0330218 0,13784053 ! muscle cell proliferation GO:0033002 8 5 0,000 0,0330218 0,13759082 ! transcription termination GO:0006353 8 5 0,000 0,0330218 0,13734201 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,0330218 0,1370941 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,0330218 0,13684709 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,0330218 0,13660096 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,0330218 0,13635571 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,0330218 0,13611135 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,0330218 0,13586786 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,0330218 0,13562524 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,0330218 0,13538348 ! apical protein localization GO:0045176 6 5 0,000 0,0330218 0,13514259 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,0330218 0,13490255 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,0330218 0,13466336 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0330218 0,13442501 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0330218 0,13418751 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,0330218 0,13395085 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,0330218 0,13371502 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,0330218 0,13348002 ! glial cell migration GO:0008347 10 5 0,000 0,0330218 0,13324585 ! determination of adult lifespan GO:0008340 8 5 0,000 0,0330218 0,13301249 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,0330218 0,13277995 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,0330218 0,13254822 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,0330218 0,1323173 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,0330218 0,13208719 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,0330218 0,13185787 ! neural plate development GO:0001840 6 5 0,000 0,0330218 0,13162935 ! regulation of sensory perception GO:0051931 6 5 0,000 0,0330218 0,13140161 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,0330218 0,13117467 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,0330218 0,13094851 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,0330218 0,13072312 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,0330218 0,13049851 ! sensory cilium assembly GO:0035058 6 5 0,000 0,0330218 0,13027467 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,0330218 0,1300516 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,0330218 0,12982929 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,0330218 0,12960774 ! spindle assembly GO:0051225 5 5 0,000 0,0330218 0,12938694 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,0330218 0,12916689 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,0330218 0,12894759 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,0330218 0,12872904 ! organ regeneration GO:0031100 7 5 0,000 0,0330218 0,12851122 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,0330218 0,12829414 ! carnitine metabolic process GO:0009437 5 5 0,000 0,0330218 0,1280778 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,0330218 0,12786218 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,0330218 0,12764728 GO:0055081|anion homeostasis, ! positive regulation of binding GO:0051099 59 43 1,000 0,03355168 0,12947796 ! methylation GO:0032259 64 43 1,000 0,03355168 0,12926108 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,0349985 0,13460961 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,0349985 0,13438488 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,03796341 0,1455264 ! histone modification GO:0016570 68 46 1,000 0,03796341 0,14528426 ! endocrine system development GO:0035270 83 47 1,000 0,03948075 0,15084006 ! covalent chromatin modification GO:0016569 75 47 1,000 0,03948075 0,15058991 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,03948075 0,15034059 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,03948075 0,15009209 ! tRNA transcription GO:0009304 11 6 0,000 0,03949524 0,14989944 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03949524 0,14965249 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03949524 0,14940635 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03949524 0,14916102 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03949524 0,1489165 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03949524 0,14867277 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03949524 0,14842984 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03949524 0,14818771 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03949524 0,14794636 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03949524 0,14770579 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03949524 0,14746601 ! prostate gland development GO:0030850 9 6 0,000 0,03949524 0,14722701 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03949524 0,14698878 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03949524 0,14675131 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03949524 0,14651462 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03949524 0,14627868 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03949524 0,14604351 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03949524 0,14580909 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03949524 0,14557542 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03949524 0,1453425 ! neuron adhesion GO:0007158 9 6 0,000 0,03949524 0,14511032 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03949524 0,14487889 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03949524 0,14464819 ! signal peptide processing GO:0006465 8 6 0,000 0,03949524 0,14441822 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03949524 0,14418899 ! mRNA stabilization GO:0048255 15 6 0,000 0,03949524 0,14396048 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03949524 0,14373269 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03949524 0,14350563 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03949524 0,14327928 ! opsonization GO:0008228 8 6 0,000 0,03949524 0,14305364 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03949524 0,14282872 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03949524 0,14260449 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03949524 0,14238098 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03949524 0,14215816 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03949524 0,14193604 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03949524 0,14171461 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03949524 0,14149387 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03949524 0,14127382 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03949524 0,14105445 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03949524 0,14083576 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03949524 0,14061774 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03949524 0,14040041 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03949524 0,14018374 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03949524 0,13996774 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03949524 0,1397524 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03949524 0,13953773 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03949524 0,13932372 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03949524 0,13911036 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03949524 0,13889765 ! thymic T cell selection GO:0045061 12 6 0,000 0,03949524 0,13868559 ! protein lipoylation GO:0009249 10 6 0,000 0,03949524 0,13847418 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03949524 0,13826341 ! pigment granule organization GO:0048753 11 6 0,000 0,03949524 0,13805329 ! drug transport GO:0015893 6 6 0,000 0,03949524 0,1378438 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03949524 0,13763494 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03949524 0,13742672 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03949524 0,13721913 ! histidine metabolic process GO:0006547 6 6 0,000 0,03949524 0,13701216 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03949524 0,13680582 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03949524 0,1366001 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03949524 0,13639499 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03949524 0,1361905 ! adenohypophysis development GO:0021984 10 6 0,000 0,03949524 0,13598662 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03949524 0,13578335 ! hyperosmotic response GO:0006972 8 6 0,000 0,03949524 0,13558069 ! microtubule nucleation GO:0007020 10 6 0,000 0,03949524 0,13537863 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03949524 0,13517718 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03949524 0,13497632 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03949524 0,13477606 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03949524 0,13457639 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03949524 0,13437731 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03949524 0,13417882 ! response to dietary excess GO:0002021 7 6 0,000 0,03949524 0,13398092 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03949524 0,1337836 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03949524 0,13358686 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03949524 0,13339069 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03949524 0,13319511 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03949524 0,13300009 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03949524 0,13280565 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03949524 0,13261177 ! neuron apoptosis GO:0051402 8 6 0,000 0,03949524 0,13241846 ! organic alcohol transport GO:0015850 9 6 0,000 0,03949524 0,13222571 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03949524 0,13203352 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03949524 0,13184189 ! carnitine transport GO:0015879 8 6 0,000 0,03949524 0,13165082 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03949524 0,13146029 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03949524 0,13127032 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03949524 0,1310809 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03949524 0,13089202 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03949524 0,13070369 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03949524 0,1305159 ! parturition GO:0007567 12 6 0,000 0,03949524 0,13032864 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03949524 0,13014192 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03949524 0,12995574 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03949524 0,12977009 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03949524 0,12958497 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03949524 0,12940037 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03949524 0,12921631 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03949524 0,12903276 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03949524 0,12884974 ! macrophage differentiation GO:0030225 10 6 0,000 0,03949524 0,12866723 ! astrocyte development GO:0014002 14 6 0,000 0,03949524 0,12848524 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03949524 0,12830376 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03949524 0,1281228 ! interaction with symbiont GO:0051702 8 6 0,000 0,03949524 0,12794234 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03949524 0,1277624 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03949524 0,12758295 ! eating behavior GO:0042755 6 6 0,000 0,03949524 0,12740402 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03949524 0,12722558 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03949524 0,12704764 ! response to copper ion GO:0046688 9 6 0,000 0,03949524 0,1268702 ! DNA topological change GO:0006265 8 6 0,000 0,03949524 0,12669325 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03949524 0,1265168 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03949524 0,12634084 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03949524 0,12616537 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03949524 0,12599038 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03949524 0,12581588 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03949524 0,12564186 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03949524 0,12546832 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03949524 0,12529526 ! gas homeostasis GO:0033483 11 6 0,000 0,03949524 0,12512268 ! hair follicle maturation GO:0048820 7 6 0,000 0,03949524 0,12495057 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03949524 0,12477893 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03949524 0,12460777 ! Schwann cell development GO:0014044 14 6 0,000 0,03949524 0,12443707 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03949524 0,12426684 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03949524 0,12409708 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03949524 0,12392778 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03949524 0,12375894 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,03949524 0,12359056 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03949524 0,12342264 ! histone ubiquitination GO:0016574 7 6 0,000 0,03949524 0,12325517 ! regulation of meiosis GO:0040020 10 6 0,000 0,03949524 0,12308816 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03949524 0,1229216 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03949524 0,12275549 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03949524 0,12258983 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03949524 0,12242461 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03949524 0,12225984 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03949524 0,12209552 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03949524 0,12193163 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03949524 0,12176818 ! receptor internalization GO:0031623 9 6 0,000 0,03949524 0,12160517 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03949524 0,1214426 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03949524 0,12128046 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03949524 0,12111875 ! protein deubiquitination GO:0016579 8 6 0,000 0,03949524 0,12095747 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03949524 0,12079663 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03949524 0,12063621 ! axonal fasciculation GO:0007413 9 6 0,000 0,03949524 0,12047621 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03949524 0,12031664 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03949524 0,12015749 ! midbrain development GO:0030901 6 6 0,000 0,03949524 0,11999876 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03949524 0,11984045 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03949524 0,11968256 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03949524 0,11952508 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03949524 0,11936802 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03949524 0,11921137 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03949524 0,11905513 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03949524 0,1188993 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03949524 0,11874387 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03949524 0,11858886 ! adult feeding behavior GO:0008343 6 6 0,000 0,03949524 0,11843424 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03949524 0,11828003 ! blastocyst growth GO:0001832 15 6 0,000 0,03949524 0,11812622 ! pigment granule transport GO:0051904 12 6 0,000 0,03949524 0,11797281 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03949524 0,1178198 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03949524 0,11766718 ! catecholamine transport GO:0051937 7 6 0,000 0,03949524 0,11751496 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03949524 0,11736313 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03949524 0,11721169 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03949524 0,11706065 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03949524 0,11690999 ! protein prenylation GO:0018342 10 6 0,000 0,03949524 0,11675972 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03949524 0,11660984 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,03949524 0,11646034 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03949524 0,11631122 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03949524 0,11616248 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03949524 0,11601413 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,04102084 0,12034176 ! heart morphogenesis GO:0003007 65 48 1,000 0,04102084 0,12018846 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,04102084 0,12003555 GO:0019724|B cell mediated immunity, ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,04102084 0,11988302 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,04258333 0,12429146 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,04258333 0,12413393 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,04258333 0,12397679 ! ear development GO:0043583 72 50 1,000 0,04416785 0,12842739 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,04416785 0,12826523 ! membrane fusion GO:0006944 80 50 1,000 0,04416785 0,12810349 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,04416785 0,12794215 ! lipid modification GO:0030258 73 50 1,000 0,04416785 0,12778121 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,04577405 0,13226169 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,04577405 0,13209574 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,04577405 0,13193021 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,04577405 0,13176509 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04592572 0,13203646 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04592572 0,13187162 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04592572 0,13170719 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04592572 0,13154317 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04592572 0,13137956 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04592572 0,13121635 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04592572 0,13105356 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04592572 0,13089116 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04592572 0,13072917 ! reproductive behavior GO:0019098 12 7 0,000 0,04592572 0,13056757 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04592572 0,13040638 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,04592572 0,13024558 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04592572 0,13008518 ! oligopeptide transport GO:0006857 11 7 0,000 0,04592572 0,12992517 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04592572 0,12976556 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04592572 0,12960634 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04592572 0,12944751 ! RNA methylation GO:0001510 11 7 0,000 0,04592572 0,12928906 ! pericardium development GO:0060039 8 7 0,000 0,04592572 0,12913101 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04592572 0,12897334 ! fibril organization GO:0043206 13 7 0,000 0,04592572 0,12881606 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04592572 0,12865915 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04592572 0,12850263 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04592572 0,1283465 ! lipoprotein transport GO:0042953 9 7 0,000 0,04592572 0,12819073 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04592572 0,12803535 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04592572 0,12788035 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04592572 0,12772571 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04592572 0,12757146 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04592572 0,12741757 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04592572 0,12726405 ! chemosensory behavior GO:0007635 9 7 0,000 0,04592572 0,12711091 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,04592572 0,12695813 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04592572 0,12680572 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04592572 0,12665368 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04592572 0,12650199 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04592572 0,12635068 ! reflex GO:0060004 12 7 0,000 0,04592572 0,12619972 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04592572 0,12604912 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04592572 0,12589889 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04592572 0,12574901 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04592572 0,12559948 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04592572 0,12545032 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04592572 0,1253015 ! spinal cord patterning GO:0021511 7 7 0,000 0,04592572 0,12515304 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04592572 0,12500493 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04592572 0,12485717 ! adrenal gland development GO:0030325 17 7 0,000 0,04592572 0,12470976 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04592572 0,1245627 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04592572 0,12441598 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04592572 0,12426961 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04592572 0,12412358 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04592572 0,12397789 ! endosome organization GO:0007032 10 7 0,000 0,04592572 0,12383255 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04592572 0,12368755 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04592572 0,12354288 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04592572 0,12339856 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04592572 0,12325457 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04592572 0,12311092 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04592572 0,1229676 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04592572 0,12282461 ! galactose metabolic process GO:0006012 10 7 0,000 0,04592572 0,12268196 ! vesicle fusion GO:0006906 15 7 0,000 0,04592572 0,12253964 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04592572 0,12239764 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04592572 0,12225598 ! organ growth GO:0035265 11 7 0,000 0,04592572 0,12211464 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04592572 0,12197363 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04592572 0,12183295 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04592572 0,12169259 ! retinol metabolic process GO:0042572 9 7 0,000 0,04592572 0,12155255 ! behavioral fear response GO:0001662 13 7 0,000 0,04592572 0,12141283 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04592572 0,12127344 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04592572 0,12113436 ! rRNA modification GO:0000154 12 7 0,000 0,04592572 0,12099561 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04592572 0,12085717 ! response to UV-B GO:0010224 11 7 0,000 0,04592572 0,12071905 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04592572 0,12058124 ! intermediate filament organization GO:0045109 11 7 0,000 0,04592572 0,12044375 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04592572 0,12030657 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04592572 0,1201697 ! fibrinolysis GO:0042730 9 7 0,000 0,04592572 0,12003314 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04592572 0,1198969 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04592572 0,11976096 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04592572 0,11962533 ! response to tropane GO:0014073 13 7 0,000 0,04592572 0,11949001 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04592572 0,11935499 ! melanosome localization GO:0032400 10 7 0,000 0,04592572 0,11922028 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04592572 0,11908587 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04592572 0,11895176 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04592572 0,11881796 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04592572 0,11868446 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04592572 0,11855125 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04592572 0,11841835 ! mast cell activation GO:0045576 9 7 0,000 0,04592572 0,11828574 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04592572 0,11815343 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04592572 0,11802141 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04592572 0,11788969 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04592572 0,11775827 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04592572 0,11762713 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04592572 0,11749629 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04592572 0,11736574 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04592572 0,11723548 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04592572 0,11710551 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04592572 0,11697582 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04592572 0,11684642 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04592572 0,11671731 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04592572 0,11658848 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04592572 0,11645994 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04592572 0,11633168 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04592572 0,1162037 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04592572 0,11607601 ! diuresis GO:0030146 12 7 0,000 0,04592572 0,11594859 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04592572 0,11582145 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04592572 0,1156946 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04592572 0,11556801 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04592572 0,11544171 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04592572 0,11531568 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04592572 0,11518993 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04592572 0,11506445 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04592572 0,11493924 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04592572 0,11481431 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04592572 0,11468965 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04592572 0,11456526 ! lymph node development GO:0048535 9 7 0,000 0,04592572 0,11444113 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04592572 0,11431728 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04592572 0,11419369 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04592572 0,11407037 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04592572 0,11394732 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04592572 0,11382453 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04592572 0,11370201 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04592572 0,11357975 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04592572 0,11345775 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04592572 0,11333601 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04592572 0,11321454 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04592572 0,11309333 ! muscle adaptation GO:0043500 12 7 0,000 0,04592572 0,11297237 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04592572 0,11285167 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04592572 0,11273123 ! retina homeostasis GO:0001895 9 7 0,000 0,04592572 0,11261105 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04592572 0,11249112 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04592572 0,11237145 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04592572 0,11225204 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04592572 0,11213287 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04592572 0,11201396 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04592572 0,1118953 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,04740155 0,11536886 ! aging GO:0007568 79 52 1,000 0,04740155 0,1152469 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,04740155 0,1151252 ! establishment of organelle localization GO:0051656 85 52 1,000 0,04740155 0,11500376 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,04905002 0,11887782 ! single fertilization GO:0007338 59 53 1,000 0,04905002 0,11875268 ! cell projection assembly GO:0030031 76 53 1,000 0,04905002 0,11862781 ! regulation of mitosis GO:0007088 84 54 1,000 0,05071911 0,12253566 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,05071911 0,12240708 ! DNA catabolic process GO:0006308 67 54 1,000 0,05071911 0,12227877 ! detection of external stimulus GO:0009581 66 54 1,000 0,05071911 0,12215073 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,05071911 0,12202295 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05231352 0,12572737 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05231352 0,12559613 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05231352 0,12546516 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05231352 0,12533447 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05231352 0,12520405 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05231352 0,1250739 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05231352 0,12494402 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05231352 0,12481441 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05231352 0,12468507 ! phosphate transport GO:0006817 10 8 0,000 0,05231352 0,12455599 ! N-glycan processing GO:0006491 12 8 0,000 0,05231352 0,12442719 ! UTP metabolic process GO:0046051 8 8 0,000 0,05231352 0,12429865 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05231352 0,12417037 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05231352 0,12404236 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05231352 0,12391461 ! succinate metabolic process GO:0006105 14 8 0,000 0,05231352 0,12378713 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05231352 0,12365991 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05231352 0,12353295 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05231352 0,12340625 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05231352 0,12327981 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05231352 0,12315362 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05231352 0,1230277 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05231352 0,12290203 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05231352 0,12277662 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05231352 0,12265147 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05231352 0,12252657 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05231352 0,12240192 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05231352 0,12227753 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05231352 0,12215339 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05231352 0,1220295 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05231352 0,12190587 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05231352 0,12178248 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05231352 0,12165934 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05231352 0,12153646 ! melanin metabolic process GO:0006582 12 8 0,000 0,05231352 0,12141381 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05231352 0,12129142 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05231352 0,12116928 ! macrophage activation GO:0042116 12 8 0,000 0,05231352 0,12104737 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05231352 0,12092572 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05231352 0,12080431 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05231352 0,12068314 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05231352 0,12056221 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05231352 0,12044153 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05231352 0,12032109 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05231352 0,12020089 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05231352 0,12008093 ! ruffle organization GO:0031529 11 8 0,000 0,05231352 0,11996121 ! osteoblast development GO:0002076 13 8 0,000 0,05231352 0,11984172 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05231352 0,11972248 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05231352 0,11960347 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05231352 0,1194847 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05231352 0,11936616 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05231352 0,11924786 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05231352 0,11912979 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05231352 0,11901196 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05231352 0,11889436 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05231352 0,11877699 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05231352 0,11865985 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05231352 0,11854295 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05231352 0,11842627 ! segment specification GO:0007379 10 8 0,000 0,05231352 0,11830982 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05231352 0,11819361 ! cellular extravasation GO:0045123 11 8 0,000 0,05231352 0,11807762 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05231352 0,11796185 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05231352 0,11784632 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05231352 0,11773101 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05231352 0,11761592 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05231352 0,11750106 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05231352 0,11738643 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05231352 0,11727202 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05231352 0,11715783 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05231352 0,11704386 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05231352 0,11693012 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05231352 0,11681659 ! icosanoid secretion GO:0032309 12 8 0,000 0,05231352 0,11670329 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05231352 0,1165902 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05231352 0,11647734 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05231352 0,11636469 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05231352 0,11625226 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05231352 0,11614005 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05231352 0,11602805 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05231352 0,11591627 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05231352 0,11580471 ! sterol catabolic process GO:0016127 9 8 0,000 0,05231352 0,11569336 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05231352 0,11558222 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05231352 0,1154713 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05231352 0,11536059 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05231352 0,11525009 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05231352 0,1151398 ! prophase GO:0051324 11 8 0,000 0,05231352 0,11502972 ! S phase GO:0051320 8 8 0,000 0,05231352 0,11491986 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05231352 0,1148102 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05231352 0,11470075 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05231352 0,11459151 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05231352 0,11448248 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05231352 0,11437366 ! hormone catabolic process GO:0042447 13 8 0,000 0,05231352 0,11426504 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05231352 0,11415663 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05231352 0,11404843 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05231352 0,11394043 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05231352 0,11383263 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05231352 0,11372504 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05231352 0,11361765 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05231352 0,11351046 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05231352 0,11340348 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05231352 0,1132967 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05231352 0,11319011 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05231352 0,11308373 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05231352 0,11297755 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05231352 0,11287157 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05231352 0,11276578 ! nucleoside metabolic process GO:0009116 69 55 1,000 0,05240846 0,11286466 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,05411775 0,11643669 ! carbohydrate transport GO:0008643 74 57 1,000 0,05584663 0,12004415 ! chromosome segregation GO:0007059 83 57 1,000 0,05584663 0,11993206 ! viral reproductive process GO:0022415 87 58 1,000 0,05759476 0,12357085 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,05759476 0,12345569 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,05759476 0,12334074 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05865891 0,12550278 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05865891 0,12538614 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05865891 0,12526972 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05865891 0,12515351 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05865891 0,12503752 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05865891 0,12492174 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05865891 0,12480618 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05865891 0,12469084 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,05865891 0,1245757 ! GTP metabolic process GO:0046039 9 9 0,000 0,05865891 0,12446078 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05865891 0,12434607 ! social behavior GO:0035176 14 9 0,000 0,05865891 0,12423157 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05865891 0,12411728 ! artery development GO:0060840 19 9 0,000 0,05865891 0,1240032 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05865891 0,12388933 ! response to pain GO:0048265 16 9 0,000 0,05865891 0,12377567 ! protein complex disassembly GO:0043241 17 9 0,000 0,05865891 0,12366222 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05865891 0,12354898 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05865891 0,12343594 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05865891 0,12332311 ! lung alveolus development GO:0048286 17 9 0,000 0,05865891 0,12321049 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05865891 0,12309807 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,05865891 0,12298586 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05865891 0,12287385 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05865891 0,12276204 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05865891 0,12265044 ! protein targeting to ER GO:0045047 19 9 0,000 0,05865891 0,12253904 ! T cell selection GO:0045058 18 9 0,000 0,05865891 0,12242784 ! endoderm development GO:0007492 12 9 0,000 0,05865891 0,12231685 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05865891 0,12220605 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05865891 0,12209546 ! arginine catabolic process GO:0006527 10 9 0,000 0,05865891 0,12198507 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05865891 0,12187487 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05865891 0,12176488 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05865891 0,12165508 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05865891 0,12154548 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05865891 0,12143608 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05865891 0,12132687 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05865891 0,12121787 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05865891 0,12110905 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05865891 0,12100043 ! mannose metabolic process GO:0006013 9 9 0,000 0,05865891 0,12089201 ! receptor clustering GO:0043113 15 9 0,000 0,05865891 0,12078378 ! epithelial cell development GO:0002064 10 9 0,000 0,05865891 0,12067575 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05865891 0,1205679 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05865891 0,12046025 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05865891 0,1203528 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05865891 0,12024553 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05865891 0,12013845 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,05865891 0,12003157 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,05865891 0,11992487 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05865891 0,11981837 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05865891 0,11971205 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05865891 0,11960593 ! DNA ligation GO:0006266 14 9 0,000 0,05865891 0,11949999 ! response to amine stimulus GO:0014075 13 9 0,000 0,05865891 0,11939423 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05865891 0,11928867 ! erythrocyte development GO:0048821 11 9 0,000 0,05865891 0,11918329 ! renal water homeostasis GO:0003091 14 9 0,000 0,05865891 0,1190781 ! postreplication repair GO:0006301 11 9 0,000 0,05865891 0,11897309 ! mRNA cleavage GO:0006379 13 9 0,000 0,05865891 0,11886827 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05865891 0,11876363 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,05865891 0,11865918 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05865891 0,11855491 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05865891 0,11845082 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05865891 0,11834692 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05865891 0,11824319 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,05865891 0,11813965 ! acid secretion GO:0046717 14 9 0,000 0,05865891 0,11803629 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05865891 0,11793312 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05865891 0,11783012 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05865891 0,1177273 ! purine base metabolic process GO:0006144 18 9 0,000 0,05865891 0,11762466 ! oocyte differentiation GO:0009994 12 9 0,000 0,05865891 0,1175222 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,05865891 0,11741992 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05865891 0,11731781 ! spleen development GO:0048536 15 9 0,000 0,05865891 0,11721589 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05865891 0,11711414 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05865891 0,11701256 ! detection of calcium ion GO:0005513 13 9 0,000 0,05865891 0,11691116 ! blastocyst formation GO:0001825 12 9 0,000 0,05865891 0,11680994 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05865891 0,1167089 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05865891 0,11660802 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05865891 0,11650733 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05865891 0,1164068 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05865891 0,11630645 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05865891 0,11620627 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05865891 0,11610627 ! prepulse inhibition GO:0060134 14 9 0,000 0,05865891 0,11600644 ! embryonic placenta development GO:0001892 12 9 0,000 0,05865891 0,11590677 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05865891 0,11580728 ! insulin secretion GO:0030073 17 9 0,000 0,05865891 0,11570796 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05865891 0,11560881 ! response to nicotine GO:0035094 16 9 0,000 0,05865891 0,11550983 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05865891 0,11541102 ! nucleus localization GO:0051647 15 9 0,000 0,05865891 0,11531238 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05865891 0,11521391 ! activation of MAPK activity GO:0000187 84 59 1,000 0,05936183 0,11649506 ! lung development GO:0030324 94 59 1,000 0,05936183 0,11639574 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,05936183 0,1162966 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,0611475 0,11969297 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,0611475 0,11959119 ! fertilization GO:0009566 68 60 1,000 0,0611475 0,11948959 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,0611475 0,11938815 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,06295144 0,12280604 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! respiratory tube development GO:0030323 99 62 1,000 0,06477335 0,12625314 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,06477335 0,12614624 ! organelle localization GO:0051640 96 62 1,000 0,06477335 0,12603951 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,06496217 0,12630007 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06496217 0,1261934 ! neuron fate specification GO:0048665 11 10 0,000 0,06496217 0,12608691 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06496217 0,1259806 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06496217 0,12587446 ! thyroid gland development GO:0030878 19 10 0,000 0,06496217 0,12576851 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06496217 0,12566273 ! synapsis GO:0007129 13 10 0,000 0,06496217 0,12555713 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06496217 0,12545171 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06496217 0,12534647 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06496217 0,1252414 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,06496217 0,12513651 ! sulfate transport GO:0008272 12 10 0,000 0,06496217 0,12503179 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06496217 0,12492725 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,06496217 0,12482288 ! androgen metabolic process GO:0008209 13 10 0,000 0,06496217 0,12471869 ! phospholipid efflux GO:0033700 16 10 0,000 0,06496217 0,12461467 ! hippocampus development GO:0021766 19 10 0,000 0,06496217 0,12451082 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,06496217 0,12440715 ! blood vessel remodeling GO:0001974 21 10 0,000 0,06496217 0,12430365 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06496217 0,12420032 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06496217 0,12409717 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,06496217 0,12399418 GO:0010812|negative regulation of cell-substrate adhesion, ! pathogenesis GO:0009405 13 10 0,000 0,06496217 0,12389137 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06496217 0,12378872 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06496217 0,12368625 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06496217 0,12358394 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06496217 0,12348181 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06496217 0,12337984 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06496217 0,12327804 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06496217 0,12317641 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06496217 0,12307495 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06496217 0,12297365 ! B cell proliferation GO:0042100 14 10 0,000 0,06496217 0,12287252 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06496217 0,12277156 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06496217 0,12267076 ! forebrain cell migration GO:0021885 17 10 0,000 0,06496217 0,12257013 ! lipid digestion GO:0044241 15 10 0,000 0,06496217 0,12246966 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06496217 0,12236936 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06496217 0,12226922 ! UV protection GO:0009650 14 10 0,000 0,06496217 0,12216925 ! entry into host cell GO:0030260 20 10 0,000 0,06496217 0,12206943 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,06496217 0,12196979 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06496217 0,1218703 ! negative regulation of ossification GO:0030279 19 10 0,000 0,06496217 0,12177098 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06496217 0,12167181 ! regulation of bone resorption GO:0045124 24 10 0,000 0,06496217 0,12157281 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,06496217 0,12147397 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06496217 0,12137529 ! regulation of organ growth GO:0046620 11 10 0,000 0,06496217 0,12127678 ! response to dsRNA GO:0043331 18 10 0,000 0,06496217 0,12117842 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06496217 0,12108022 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06496217 0,12098218 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06496217 0,12088429 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06496217 0,12078657 ! cranial nerve development GO:0021545 12 10 0,000 0,06496217 0,120689 ! fucose catabolic process GO:0019317 16 10 0,000 0,06496217 0,1205916 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06496217 0,12049435 ! protein sumoylation GO:0016925 12 10 0,000 0,06496217 0,12039725 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06496217 0,12030031 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06496217 0,12020353 ! zymogen activation GO:0031638 14 10 0,000 0,06496217 0,1201069 ! salivary gland development GO:0007431 22 10 0,000 0,06496217 0,12001043 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06496217 0,11991412 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06496217 0,11981795 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06496217 0,11972195 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06496217 0,11962609 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,06496217 0,11953039 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06496217 0,11943484 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06496217 0,11933945 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06496217 0,1192442 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06496217 0,11914911 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06496217 0,11905417 ! detection of bacterium GO:0016045 10 10 0,000 0,06496217 0,11895939 ! embryonic gut development GO:0048566 11 10 0,000 0,06496217 0,11886475 ! activation of innate immune response GO:0002218 10 10 0,000 0,06496217 0,11877026 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06496217 0,11867592 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,06496217 0,11858174 ! developmental induction GO:0031128 13 10 0,000 0,06496217 0,1184877 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06496217 0,11839381 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06496217 0,11830007 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06496217 0,11820648 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,0666129 0,12111436 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,0666129 0,12101869 ! viral reproduction GO:0016032 92 63 1,000 0,0666129 0,12092318 ! regulation of lipase activity GO:0060191 109 63 1,000 0,0666129 0,12082781 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,06846978 0,1240981 ! respiratory system development GO:0060541 100 64 1,000 0,06846978 0,12400038 ! adaptive immune response GO:0002250 94 64 1,000 0,06846978 0,12390282 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,07034367 0,12719375 ! rRNA transcription GO:0009303 17 11 0,000 0,07122358 0,12868361 ! respiratory burst GO:0045730 14 11 0,000 0,07122358 0,12858261 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07122358 0,12848176 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07122358 0,12838107 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07122358 0,12828053 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07122358 0,12818016 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,07122358 0,12807994 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07122358 0,12797988 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07122358 0,12787997 ! mating GO:0007618 14 11 0,000 0,07122358 0,12778022 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,07122358 0,12768062 ! T cell proliferation GO:0042098 20 11 0,000 0,07122358 0,12758118 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07122358 0,1274819 ! bone resorption GO:0045453 16 11 0,000 0,07122358 0,12738277 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07122358 0,12728379 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07122358 0,12718497 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07122358 0,1270863 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,07122358 0,12698778 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07122358 0,12688942 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07122358 0,12679121 ! syncytium formation GO:0006949 15 11 0,000 0,07122358 0,12669315 ! plasma membrane organization GO:0007009 18 11 0,000 0,07122358 0,12659524 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07122358 0,12649748 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07122358 0,12639988 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07122358 0,12630242 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07122358 0,12620512 ! adult heart development GO:0007512 11 11 0,000 0,07122358 0,12610796 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,07122358 0,12601095 ! temperature homeostasis GO:0001659 16 11 0,000 0,07122358 0,1259141 ! L-glutamate transport GO:0015813 16 11 0,000 0,07122358 0,12581739 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07122358 0,12572083 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07122358 0,12562442 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07122358 0,12552815 ! stem cell development GO:0048864 29 11 0,000 0,07122358 0,12543204 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07122358 0,12533607 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07122358 0,12524024 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07122358 0,12514457 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07122358 0,12504904 ! vasoconstriction GO:0042310 15 11 0,000 0,07122358 0,12495365 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07122358 0,12485841 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07122358 0,12476332 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07122358 0,12466837 ! ribosome assembly GO:0042255 13 11 0,000 0,07122358 0,12457357 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07122358 0,12447891 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07122358 0,12438439 ! chromatin silencing GO:0006342 19 11 0,000 0,07122358 0,12429002 ! nucleosome positioning GO:0016584 13 11 0,000 0,07122358 0,12419578 ! T cell homeostasis GO:0043029 20 11 0,000 0,07122358 0,1241017 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07122358 0,12400775 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,07122358 0,12391395 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07122358 0,12382029 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07122358 0,12372677 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07122358 0,12363339 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07122358 0,12354015 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07122358 0,12344705 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07122358 0,1233541 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07122358 0,12326128 ! male genitalia development GO:0030539 13 11 0,000 0,07122358 0,1231686 ! cholesterol efflux GO:0033344 19 11 0,000 0,07122358 0,12307606 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07122358 0,12298366 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07122358 0,1228914 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07122358 0,12279928 ! germ cell migration GO:0008354 18 11 0,000 0,07122358 0,1227073 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07122358 0,12261545 ! defense response to fungus GO:0050832 12 11 0,000 0,07122358 0,12252374 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07122358 0,12243217 ! lysogeny GO:0030069 18 11 0,000 0,07122358 0,12234073 GO:0019047|provirus integration, ! acrosome reaction GO:0007340 13 11 0,000 0,07122358 0,12224943 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07122358 0,12215827 ! axon guidance GO:0007411 99 66 1,000 0,07223429 0,12379945 ! acute inflammatory response GO:0002526 92 68 1,000 0,07606444 0,13026673 ! learning or memory GO:0007611 123 68 1,000 0,07606444 0,1301698 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,07606444 0,13007302 ! lactation GO:0007595 20 12 0,000 0,07744342 0,13233274 ! reproductive cellular process GO:0048610 14 12 0,000 0,07744342 0,1322345 ! tRNA modification GO:0006400 14 12 0,000 0,07744342 0,13213641 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,07744342 0,13203845 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,07744342 0,13194065 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,07744342 0,13184299 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,07744342 0,13174547 ! non-recombinational repair GO:0000726 19 12 0,000 0,07744342 0,1316481 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,07744342 0,13155087 ! peroxisomal transport GO:0043574 21 12 0,000 0,07744342 0,13145378 ! cartilage condensation GO:0001502 18 12 0,000 0,07744342 0,13135684 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,07744342 0,13126004 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,07744342 0,13116338 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,07744342 0,13106687 ! heart looping GO:0001947 15 12 0,000 0,07744342 0,1309705 ! palate development GO:0060021 15 12 0,000 0,07744342 0,13087426 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,07744342 0,13077818 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,07744342 0,13068223 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,07744342 0,13058642 ! arginine metabolic process GO:0006525 13 12 0,000 0,07744342 0,13049075 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,07744342 0,13039522 ! methionine metabolic process GO:0006555 13 12 0,000 0,07744342 0,13029984 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,07744342 0,13020459 ! Golgi organization GO:0007030 18 12 0,000 0,07744342 0,13010948 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,07744342 0,13001451 ! monoamine transport GO:0015844 13 12 0,000 0,07744342 0,12991968 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07744342 0,12982498 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,07744342 0,12973043 ! L-amino acid transport GO:0015807 20 12 0,000 0,07744342 0,12963601 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,07744342 0,12954173 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,07744342 0,12944758 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,07744342 0,12935358 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07744342 0,12925971 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,07744342 0,12916597 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,07744342 0,12907237 ! cerebellum development GO:0021549 13 12 0,000 0,07744342 0,12897891 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,07744342 0,12888558 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,07744342 0,12879239 ! histone methylation GO:0016571 15 12 0,000 0,07744342 0,12869933 ! autonomic nervous system development GO:0048483 23 12 0,000 0,07744342 0,12860641 ! gland morphogenesis GO:0022612 23 12 0,000 0,07744342 0,12851362 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,07744342 0,12842096 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,07744342 0,12832844 ! regulation of epidermis development GO:0045682 17 12 0,000 0,07744342 0,12823605 ! intestinal absorption GO:0050892 19 12 0,000 0,07744342 0,12814379 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,07744342 0,12805167 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,07744342 0,12795968 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,07744342 0,12786782 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,07744342 0,12777609 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,07744342 0,1276845 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,07744342 0,12759303 ! microspike assembly GO:0030035 23 12 0,000 0,07744342 0,1275017 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,07744342 0,1274105 ! response to cold GO:0009409 14 12 0,000 0,07744342 0,12731942 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,07800339 0,12814842 ! response to metal ion GO:0010038 103 70 1,000 0,07995785 0,13126557 ! humoral immune response GO:0006959 86 70 1,000 0,07995785 0,13117194 ! eye development GO:0001654 111 70 1,000 0,07995785 0,13107845 ! regulation of catabolic process GO:0009894 106 70 1,000 0,07995785 0,13098509 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,08192755 0,13411627 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,08192755 0,13402088 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,08192755 0,13392563 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,08362197 0,13659838 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08362197 0,13650143 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08362197 0,13640462 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,08362197 0,13630795 ! water transport GO:0006833 17 13 0,000 0,08362197 0,13621142 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08362197 0,13611502 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08362197 0,13601876 ! lipid localization GO:0010876 24 13 0,000 0,08362197 0,13592263 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08362197 0,13582664 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08362197 0,13573078 ! organelle fusion GO:0048284 28 13 0,000 0,08362197 0,13563506 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08362197 0,13553948 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08362197 0,13544403 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08362197 0,13534871 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08362197 0,13525353 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08362197 0,13515848 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08362197 0,13506357 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08362197 0,13496879 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08362197 0,13487414 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08362197 0,13477962 ! NAD metabolic process GO:0019674 21 13 0,000 0,08362197 0,13468524 ! exocrine system development GO:0035272 27 13 0,000 0,08362197 0,13459099 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,08362197 0,13449687 ! bone mineralization GO:0030282 15 13 0,000 0,08362197 0,13440288 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08362197 0,13430902 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08362197 0,1342153 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08362197 0,1341217 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08362197 0,13402824 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08362197 0,1339349 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08362197 0,1338417 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,08362197 0,13374862 ! genitalia development GO:0048806 15 13 0,000 0,08362197 0,13365568 ! cellular pigmentation GO:0033059 24 13 0,000 0,08362197 0,13356286 ! tissue regeneration GO:0042246 21 13 0,000 0,08362197 0,13347017 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,08362197 0,13337761 ! cofactor transport GO:0051181 19 13 0,000 0,08362197 0,13328518 ! NADP metabolic process GO:0006739 18 13 0,000 0,08362197 0,13319288 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08362197 0,13310071 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08362197 0,13300866 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08362197 0,13291674 ! gas transport GO:0015669 18 13 0,000 0,08362197 0,13282494 ! regulation of RNA stability GO:0043487 28 13 0,000 0,08362197 0,13273328 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08362197 0,13264174 ! regulation of axon extension GO:0030516 23 13 0,000 0,08362197 0,13255032 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08362197 0,13245904 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,08362197 0,13236787 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08362197 0,13227684 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08362197 0,13218592 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08362197 0,13209514 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08362197 0,13200447 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,08792516 0,13870224 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,08975948 0,14149884 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,08975948 0,14140192 ! superoxide anion generation GO:0042554 18 14 0,000 0,08975948 0,14130513 ! neuron maturation GO:0042551 21 14 0,000 0,08975948 0,14120848 ! regulation of S phase GO:0033261 18 14 0,000 0,08975948 0,14111196 ! myotube differentiation GO:0014902 21 14 0,000 0,08975948 0,14101558 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,08975948 0,14091932 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08975948 0,14082319 ! inositol metabolic process GO:0006020 20 14 0,000 0,08975948 0,1407272 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08975948 0,14063134 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08975948 0,1405356 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08975948 0,14044 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08975948 0,14034453 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08975948 0,14024919 ! response to cAMP GO:0051591 19 14 0,000 0,08975948 0,14015397 ! limbic system development GO:0021761 25 14 0,000 0,08975948 0,14005889 ! startle response GO:0001964 21 14 0,000 0,08975948 0,13996393 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,08975948 0,13986911 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08975948 0,13977441 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08975948 0,13967984 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08975948 0,1395854 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,08975948 0,13949108 ! glycine metabolic process GO:0006544 22 14 0,000 0,08975948 0,1393969 ! pituitary gland development GO:0021983 23 14 0,000 0,08975948 0,13930284 ! lysosomal transport GO:0007041 20 14 0,000 0,08975948 0,1392089 ! regulation of heart rate GO:0002027 23 14 0,000 0,08975948 0,1391151 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08975948 0,13902142 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,08975948 0,13892786 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,08975948 0,13883443 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08975948 0,13874113 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08975948 0,13864795 ! axon cargo transport GO:0008088 27 14 0,000 0,08975948 0,1385549 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08975948 0,13846197 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,08975948 0,13836917 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08975948 0,13827649 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,08975948 0,13818394 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08975948 0,13809151 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08975948 0,1379992 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08975948 0,13790702 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08975948 0,13781495 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08975948 0,13772302 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08975948 0,1376312 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,08975948 0,13753951 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,08975948 0,13744794 ! muscle maintenance GO:0046716 19 14 0,000 0,08975948 0,13735649 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08975948 0,13726516 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08975948 0,13717395 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08975948 0,13708287 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,08975948 0,13699191 ! cell killing GO:0001906 20 14 0,000 0,08975948 0,13690106 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,08975948 0,13681034 ! cilium assembly GO:0042384 20 14 0,000 0,08975948 0,13671974 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08975948 0,13662925 ! blood coagulation GO:0007596 116 75 1,000 0,08995294 0,13683317 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,08995294 0,13674273 ! tRNA metabolic process GO:0006399 95 76 1,000 0,09199454 0,13975392 ! response to unfolded protein GO:0006986 99 76 1,000 0,09199454 0,13966167 ! regulation of protein transport GO:0051223 114 76 1,000 0,09199454 0,13956955 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 1,000 0,09404969 0,14259346 ! gland development GO:0048732 148 77 1,000 0,09404969 0,14249953 ! protein ubiquitination GO:0016567 125 77 1,000 0,09404969 0,14240572 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,09404969 0,14231203 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,09585624 0,14495026 ! metencephalon development GO:0022037 19 15 0,000 0,09585624 0,14485502 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,09585624 0,14475991 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,09585624 0,14466492 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,09585624 0,14457006 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,09585624 0,14447532 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,09585624 0,14438071 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,09585624 0,14428622 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,09585624 0,14419185 ! bile acid metabolic process GO:0008206 22 15 0,000 0,09585624 0,14409761 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,09585624 0,14400349 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,09585624 0,14390949 ! adult walking behavior GO:0007628 25 15 0,000 0,09585624 0,14381562 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,09585624 0,14372187 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,09585624 0,14362824 ! myoblast differentiation GO:0045445 27 15 0,000 0,09585624 0,14353473 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,09585624 0,14344134 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,09585624 0,14334808 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,09585624 0,14325493 ! cerebral cortex development GO:0021987 29 15 0,000 0,09585624 0,14316191 ! response to osmotic stress GO:0006970 22 15 0,000 0,09585624 0,14306901 ! vesicle coating GO:0006901 25 15 0,000 0,09585624 0,14297623 ! DNA integration GO:0015074 22 15 0,000 0,09585624 0,14288357 ! peptide secretion GO:0002790 27 15 0,000 0,09585624 0,14279102 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,09585624 0,1426986 ! regulation of vasodilation GO:0042312 24 15 0,000 0,09585624 0,1426063 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,09585624 0,14251412 ! neuron recognition GO:0008038 22 15 0,000 0,09585624 0,14242206 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,09585624 0,14233011 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,09585624 0,14223828 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,09585624 0,14214658 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,09585624 0,14205499 ! biomineral formation GO:0031214 18 15 0,000 0,09585624 0,14196352 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,09585624 0,14187216 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,09585624 0,14178093 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,09585624 0,14168981 ! dopamine metabolic process GO:0042417 30 15 0,000 0,09585624 0,14159881 ! organic cation transport GO:0015695 19 15 0,000 0,09585624 0,14150792 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,09585624 0,14141715 GO:0033014|tetrapyrrole biosynthetic process, ! defense response to virus GO:0051607 27 15 0,000 0,09585624 0,1413265 ! peptide hormone processing GO:0016486 19 15 0,000 0,09585624 0,14123597 ! T cell activation GO:0042110 134 79 1,000 0,09819958 0,14459605 ! chromatin assembly GO:0031497 102 80 1,000 0,10029379 0,14758523 GO:0006334|nucleosome assembly, ! protein secretion GO:0009306 27 16 0,000 0,1019125 0,14987133 ! hormone secretion GO:0046879 25 16 0,000 0,1019125 0,14977556 ! bone remodeling GO:0046849 24 16 0,000 0,1019125 0,14967992 ! endothelial cell migration GO:0043542 22 16 0,000 0,1019125 0,1495844 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,1019125 0,149489 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,1019125 0,14939373 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,1019125 0,14929857 ! glial cell development GO:0021782 24 16 0,000 0,1019125 0,14920354 ! patterning of blood vessels GO:0001569 24 16 0,000 0,1019125 0,14910862 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,1019125 0,14901383 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,1019125 0,14891916 ! protein polyubiquitination GO:0000209 26 16 0,000 0,1019125 0,14882461 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,1019125 0,14873018 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,1019125 0,14863586 ! fructose metabolic process GO:0006000 20 16 0,000 0,1019125 0,14854167 ! regulation of protein binding GO:0043393 27 16 0,000 0,1019125 0,1484476 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,1019125 0,14835364 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,1019125 0,14825981 ! protein export from nucleus GO:0006611 24 16 0,000 0,1019125 0,14816609 ! negative regulation of immune response GO:0050777 28 16 0,000 0,1019125 0,14807249 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,1019125 0,14797901 ! DNA replication initiation GO:0006270 25 16 0,000 0,1019125 0,14788565 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,1019125 0,14779241 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,1019125 0,14769928 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,1019125 0,14760627 ! diencephalon development GO:0021536 25 16 0,000 0,1019125 0,14751338 ! oogenesis GO:0048477 23 16 0,000 0,1019125 0,1474206 ! neural crest cell migration GO:0001755 24 16 0,000 0,1019125 0,14732794 ! G1 phase GO:0051318 27 16 0,000 0,1019125 0,1472354 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,1019125 0,14714297 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,1019125 0,14705066 ! steroid catabolic process GO:0006706 22 16 0,000 0,1019125 0,14695847 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,1019125 0,14686639 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,1019125 0,14677442 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,1019125 0,14668258 ! sperm-egg recognition GO:0035036 16 16 0,000 0,1019125 0,14659084 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,1019125 0,14649922 ! nerve development GO:0021675 18 16 0,000 0,1019125 0,14640772 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,1019125 0,14631633 ! negative regulation of translation GO:0017148 22 16 0,000 0,1019125 0,14622505 ! hemostasis GO:0007599 125 81 1,000 0,10240049 0,14683362 ! mRNA transport GO:0051028 121 81 1,000 0,10240049 0,14674214 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,10240049 0,14665077 ! response to protein stimulus GO:0051789 111 81 1,000 0,10240049 0,14655951 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,10240049 0,14646837 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,10451943 0,14940627 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,10451943 0,14931348 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,10665036 0,15226308 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,10792855 0,15399234 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,10792855 0,15389687 ! negative regulation of defense response GO:0031348 19 17 0,000 0,10792855 0,15380152 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,10792855 0,15370629 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,10792855 0,15361118 ! glycerol metabolic process GO:0006071 20 17 0,000 0,10792855 0,15351618 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,10792855 0,1534213 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,10792855 0,15332653 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,10792855 0,15323189 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,10792855 0,15313736 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,10792855 0,15304295 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,10792855 0,15294865 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,10792855 0,15285447 ! memory GO:0007613 25 17 0,000 0,10792855 0,15276041 ! keratinization GO:0031424 17 17 0,000 0,10792855 0,15266646 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,10792855 0,15257262 ! retinoid metabolic process GO:0001523 22 17 0,000 0,10792855 0,15247891 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,10792855 0,1523853 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,10792855 0,15229182 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,10792855 0,15219844 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,10792855 0,15210518 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,10792855 0,15201204 ! membrane budding GO:0006900 29 17 0,000 0,10792855 0,15191901 ! heme metabolic process GO:0042168 27 17 0,000 0,10792855 0,15182609 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,10792855 0,15173329 ! body fluid secretion GO:0007589 27 17 0,000 0,10792855 0,1516406 ! stem cell differentiation GO:0048863 36 17 0,000 0,10792855 0,15154802 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,10792855 0,15145556 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,10792855 0,15136321 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,10792855 0,15127097 ! sensory perception of pain GO:0019233 23 17 0,000 0,10792855 0,15117884 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,10792855 0,15108683 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,10792855 0,15099493 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,10792855 0,15090314 ! synaptogenesis GO:0007416 24 17 0,000 0,10792855 0,15081146 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,10792855 0,15071989 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,10792855 0,15062843 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,10792855 0,15053709 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,10792855 0,15044585 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,10792855 0,15035473 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,10792855 0,15026372 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,10792855 0,15017281 ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,10879301 0,15128411 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,11094714 0,15418636 ! transcription initiation GO:0006352 118 85 1,000 0,11094714 0,15409325 ! regulation of protein localization GO:0032880 132 85 1,000 0,11094714 0,15400026 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,11094714 0,15390738 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,11390463 0,1579148 ! positive regulation of translation GO:0045727 28 18 0,000 0,11390463 0,15781967 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,11390463 0,15772466 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,11390463 0,15762976 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,11390463 0,15753497 ! cAMP metabolic process GO:0046058 33 18 0,000 0,11390463 0,1574403 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,11390463 0,15734574 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,11390463 0,1572513 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,11390463 0,15715696 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,11390463 0,15706275 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,11390463 0,15696864 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,11390463 0,15687465 ! glutamine metabolic process GO:0006541 23 18 0,000 0,11390463 0,15678077 ! response to retinoic acid GO:0032526 25 18 0,000 0,11390463 0,156687 ! pigmentation during development GO:0048066 31 18 0,000 0,11390463 0,15659334 ! central nervous system neuron development GO:0021954 30 18 0,000 0,11390463 0,1564998 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,11390463 0,15640636 ! fucose metabolic process GO:0006004 26 18 0,000 0,11390463 0,15631304 ! response to fungus GO:0009620 19 18 0,000 0,11390463 0,15621983 ! peptide cross-linking GO:0018149 31 18 0,000 0,11390463 0,15612673 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,11390463 0,15603375 ! heart process GO:0003015 27 18 0,000 0,11390463 0,15594087 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,11390463 0,1558481 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,11390463 0,15575545 ! visual learning GO:0008542 35 18 0,000 0,11390463 0,1556629 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,11390463 0,15557046 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,11390463 0,15547814 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,11390463 0,15538592 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,11390463 0,15529381 ! vitamin transport GO:0051180 24 18 0,000 0,11390463 0,15520181 ! hormone transport GO:0009914 27 18 0,000 0,11390463 0,15510992 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,11390463 0,15501814 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,11390463 0,15492647 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,11390463 0,15483491 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,11390463 0,15474345 ! cell-cell recognition GO:0009988 20 18 0,000 0,11390463 0,1546521 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,11390463 0,15456086 ! gut development GO:0048565 26 18 0,000 0,11390463 0,15446973 ! nucleosome organization GO:0034728 114 87 1,000 0,11528888 0,15625481 ! establishment of RNA localization GO:0051236 128 88 1,000 0,11747599 0,15912531 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of neurogenesis GO:0050767 153 89 1,000 0,11967361 0,16200666 ! reproductive developmental process GO:0003006 127 89 1,000 0,11967361 0,16191136 ! regulation of T cell activation GO:0050863 128 89 1,000 0,11967361 0,16181618 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,11984103 0,16194733 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,11984103 0,16185224 ! positive regulation of ossification GO:0045778 30 19 0,000 0,11984103 0,16175725 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,11984103 0,16166238 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,11984103 0,16156762 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,11984103 0,16147297 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,11984103 0,16137843 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,11984103 0,161284 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,11984103 0,16118969 ! regeneration GO:0031099 32 19 0,000 0,11984103 0,16109548 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,11984103 0,16100138 ! sensory perception of taste GO:0050909 23 19 0,000 0,11984103 0,16090739 ! smooth muscle contraction GO:0006939 36 19 0,000 0,11984103 0,16081351 ! peroxisome organization GO:0007031 29 19 0,000 0,11984103 0,16071974 ! digestive system process GO:0022600 30 19 0,000 0,11984103 0,16062609 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,11984103 0,16053253 ! response to vitamin A GO:0033189 26 19 0,000 0,11984103 0,16043909 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,11984103 0,16034576 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,11984103 0,16025254 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,11984103 0,16015942 ! cytolysis GO:0019835 20 19 0,000 0,11984103 0,16006641 ! renal system process GO:0003014 35 19 0,000 0,11984103 0,15997351 ! vasodilation GO:0042311 33 19 0,000 0,11984103 0,15988072 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,11984103 0,15978804 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,11984103 0,15969546 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,11984103 0,15960299 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,11984103 0,15951063 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,11984103 0,15941837 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,11984103 0,15932622 ! sarcomere organization GO:0045214 23 19 0,000 0,11984103 0,15923418 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,11984103 0,15914224 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,11984103 0,15905041 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,11984103 0,15895869 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,11984103 0,15886707 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,11984103 0,15877555 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,11984103 0,15868415 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,11984103 0,15859284 ! protein stabilization GO:0050821 26 19 0,000 0,11984103 0,15850165 ! RNA localization GO:0006403 135 91 1,000 0,12409947 0,16403953 ! ATP metabolic process GO:0046034 137 91 1,000 0,12409947 0,1639453 ! response to virus GO:0009615 122 91 1,000 0,12409947 0,16385119 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,12573799 0,16591932 ! iron ion transport GO:0006826 37 20 0,000 0,12573799 0,16582418 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,12573799 0,16572915 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,12573799 0,16563423 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,12573799 0,16553942 ! response to vitamin GO:0033273 29 20 0,000 0,12573799 0,16544472 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,12573799 0,16535012 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,12573799 0,16525564 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,12573799 0,16516126 ! spinal cord development GO:0021510 31 20 0,000 0,12573799 0,16506699 ! response to ethanol GO:0045471 37 20 0,000 0,12573799 0,16497283 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,12573799 0,16487877 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,12573799 0,16478483 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,12573799 0,16469098 ! chromosome condensation GO:0030261 31 20 0,000 0,12573799 0,16459725 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,12573799 0,16450362 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,12573799 0,1644101 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,12573799 0,16431669 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,12573799 0,16422338 ! pallium development GO:0021543 38 20 0,000 0,12573799 0,16413017 ! collagen fibril organization GO:0030199 45 20 0,000 0,12573799 0,16403708 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,12573799 0,16394409 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,12573799 0,1638512 ! collagen catabolic process GO:0030574 25 20 0,000 0,12573799 0,16375842 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,12573799 0,16366574 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,12573799 0,16357317 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,12573799 0,16348071 ! alditol metabolic process GO:0019400 24 20 0,000 0,12573799 0,16338834 ! actin filament-based movement GO:0030048 34 20 0,000 0,12573799 0,16329609 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,12632723 0,16396875 ! cell fate commitment GO:0045165 141 92 1,000 0,12632723 0,16387627 ! sulfur metabolic process GO:0006790 118 92 1,000 0,12632723 0,16378389 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,12856458 0,16659072 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,12856458 0,16649692 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,13159577 0,17032655 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,13159577 0,17023075 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,13159577 0,17013506 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,13159577 0,17003948 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,13159577 0,16994401 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,13159577 0,16984864 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,13159577 0,16975338 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,13159577 0,16965823 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,13159577 0,16956318 ! vesicle docking GO:0048278 27 21 0,000 0,13159577 0,16946824 ! phototransduction GO:0007602 25 21 0,000 0,13159577 0,16937341 ! visual behavior GO:0007632 39 21 0,000 0,13159577 0,16927868 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,13159577 0,16918406 ! ovarian follicle development GO:0001541 30 21 0,000 0,13159577 0,16908954 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,13159577 0,16899513 ! autophagy GO:0006914 28 21 0,000 0,13159577 0,16890082 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,13159577 0,16880662 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,13159577 0,16871253 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,13159577 0,16861854 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,13159577 0,16852465 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,13159577 0,16843087 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,13159577 0,16833719 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,13159577 0,16824362 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,13159577 0,16815015 ! fatty acid transport GO:0015908 30 21 0,000 0,13159577 0,16805679 ! immunoglobulin production GO:0002377 33 21 0,000 0,13159577 0,16796353 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,13159577 0,16787037 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,13159577 0,16777731 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,13159577 0,16768436 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,13159577 0,16759151 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,13159577 0,16749877 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,13159577 0,16740613 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,13159577 0,16731359 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,13159577 0,16722115 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,13159577 0,16712881 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,13159577 0,16703658 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,13159577 0,16694444 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,13159577 0,16685241 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,13159577 0,16676048 ! regulation of binding GO:0051098 151 95 1,000 0,13306714 0,16853217 ! in utero embryonic development GO:0001701 147 96 1,000 0,13533191 0,17130622 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,13533191 0,17121199 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,13741464 0,17375133 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,13741464 0,17365587 ! viral genome replication GO:0019079 29 22 0,000 0,13741464 0,1735605 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,13741464 0,17346525 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,13741464 0,17337009 ! leukocyte adhesion GO:0007159 38 22 0,000 0,13741464 0,17327504 ! molting cycle process GO:0022404 40 22 0,000 0,13741464 0,1731801 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,13741464 0,17308526 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,13741464 0,17299052 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,13741464 0,17289588 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,13741464 0,17280135 ! vasculogenesis GO:0001570 33 22 0,000 0,13741464 0,17270693 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,13741464 0,1726126 GO:0010810|regulation of cell-substrate adhesion, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,13741464 0,17251838 ! lysosome organization GO:0007040 37 22 0,000 0,13741464 0,17242426 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,13741464 0,17233025 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,13741464 0,17223634 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,13741464 0,17214253 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,13741464 0,17204882 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,13741464 0,17195521 ! membrane depolarization GO:0051899 35 22 0,000 0,13741464 0,17186171 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,13741464 0,1717683 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,13741464 0,171675 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,13741464 0,1715818 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,13741464 0,1714887 ! blastocyst development GO:0001824 37 22 0,000 0,13741464 0,1713957 ! neural tube closure GO:0001843 33 22 0,000 0,13741464 0,17130281 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,13741464 0,17121001 ! calcium ion transport GO:0006816 167 99 1,000 0,14217757 0,17704841 ! extracellular structure organization GO:0043062 156 99 1,000 0,14217757 0,17695261 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,14319485 0,17812232 ! neuron fate commitment GO:0048663 32 23 0,000 0,14319485 0,17802603 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,14319485 0,17792986 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,14319485 0,17783378 ! vesicle targeting GO:0006903 32 23 0,000 0,14319485 0,17773781 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,14319485 0,17764194 ! osteoblast differentiation GO:0001649 40 23 0,000 0,14319485 0,17754618 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,14319485 0,17745052 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,14319485 0,17735496 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,14319485 0,17725951 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,14319485 0,17716415 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,14319485 0,1770689 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,14319485 0,17697376 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,14319485 0,17687871 ! cell fate determination GO:0001709 45 23 0,000 0,14319485 0,17678377 ! pentose metabolic process GO:0019321 31 23 0,000 0,14319485 0,17668893 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,14319485 0,17659419 ! spermatid development GO:0007286 33 23 0,000 0,14319485 0,17649955 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,14319485 0,17640502 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,14319485 0,17631058 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,14319485 0,17621625 ! telomere organization GO:0032200 32 23 0,000 0,14319485 0,17612201 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,14319485 0,17602788 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,14319485 0,17593385 ! regulation of amine transport GO:0051952 38 23 0,000 0,14319485 0,17583992 ! liver development GO:0001889 40 23 0,000 0,14319485 0,17574608 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,14447587 0,17722373 ! divalent metal ion transport GO:0070838 171 100 1,000 0,14447587 0,17712926 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,14447587 0,17703489 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,14447587 0,17694063 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,14893666 0,18230672 ! initiation of viral infection GO:0019059 42 24 0,000 0,14893666 0,18220974 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,14893666 0,18211288 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,14893666 0,18201611 ! superoxide metabolic process GO:0006801 32 24 0,000 0,14893666 0,18191945 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,14893666 0,18182289 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,14893666 0,18172643 ! sperm motility GO:0030317 27 24 0,000 0,14893666 0,18163007 ! vacuole organization GO:0007033 39 24 0,000 0,14893666 0,18153382 ! receptor metabolic process GO:0043112 37 24 0,000 0,14893666 0,18143767 ! neural crest cell development GO:0014032 39 24 0,000 0,14893666 0,18134162 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,14893666 0,18124567 ! primary neural tube formation GO:0014020 35 24 0,000 0,14893666 0,18114982 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,14893666 0,18105408 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,14893666 0,18095844 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,14893666 0,18086289 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,14893666 0,18076745 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,14893666 0,18067211 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,14893666 0,18057687 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,15464032 0,18739343 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,15464032 0,18729475 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,15464032 0,18719617 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,15464032 0,1870977 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,15464032 0,18699933 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,15464032 0,18690106 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,15464032 0,1868029 ! peptide transport GO:0015833 43 25 0,000 0,15464032 0,18670484 ! male gonad development GO:0008584 33 25 0,000 0,15464032 0,18660689 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,15464032 0,18650903 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,15464032 0,18641128 ! phospholipid transport GO:0015914 35 25 0,000 0,15464032 0,18631363 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,15464032 0,18621609 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,15464032 0,18611864 ! detection of light stimulus GO:0009583 30 25 0,000 0,15464032 0,1860213 ! leukocyte proliferation GO:0070661 39 25 0,000 0,15464032 0,18592406 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,16030607 0,1926353 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,16030607 0,19253471 ! translational initiation GO:0006413 43 26 0,000 0,16030607 0,19243422 ! circadian rhythm GO:0007623 42 26 0,000 0,16030607 0,19233383 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,16030607 0,19223356 ! post-embryonic development GO:0009791 42 26 0,000 0,16030607 0,19213338 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,16030607 0,19203331 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,16030607 0,19193335 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,16030607 0,19183349 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,16030607 0,19173373 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,16030607 0,19163408 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,16030607 0,19153453 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,16593417 0,19815608 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,16593417 0,19805324 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,16593417 0,19795052 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,16593417 0,1978479 ! membrane docking GO:0022406 39 27 0,000 0,16593417 0,19774539 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,16593417 0,19764298 ! catechol metabolic process GO:0009712 43 27 0,000 0,16593417 0,19754068 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,16593417 0,19743849 ! acute-phase response GO:0006953 42 27 0,000 0,16593417 0,1973364 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,16593417 0,19723442 ! myofibril assembly GO:0030239 36 27 0,000 0,16593417 0,19713254 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,16593417 0,19703077 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,16593417 0,1969291 ! natural killer cell activation GO:0030101 35 27 0,000 0,16593417 0,19682754 ! lipid oxidation GO:0034440 38 27 0,000 0,16593417 0,19672608 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,16593417 0,19662473 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,16593417 0,19652348 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,16593417 0,19642234 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,16593417 0,1963213 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,16593417 0,19622036 ! gene silencing GO:0016458 41 27 0,000 0,16593417 0,19611953 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,17152488 0,20262312 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,17152488 0,2025191 ! phenol metabolic process GO:0018958 44 28 0,000 0,17152488 0,2024152 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,17152488 0,20231139 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,17152488 0,2022077 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,17152488 0,20210411 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,17152488 0,20200062 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,17152488 0,20189724 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,17152488 0,20179397 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,17152488 0,20169081 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,17152488 0,20158774 ! response to organic cyclic substance GO:0014070 47 28 0,000 0,17152488 0,20148479 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,17152488 0,20138194 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,17152488 0,20127919 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,17152488 0,20117655 ! mesoderm formation GO:0001707 46 28 0,000 0,17152488 0,20107401 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,17152488 0,20097158 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,17152488 0,20086925 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,17152488 0,20076703 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,17152488 0,20066491 ! neural tube formation GO:0001841 41 28 0,000 0,17152488 0,2005629 ! placenta development GO:0001890 37 28 0,000 0,17152488 0,20046098 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,17707842 0,2068463 ! regulation of innate immune response GO:0045088 38 29 0,000 0,17707842 0,20674131 ! ovulation cycle process GO:0022602 41 29 0,000 0,17707842 0,20663641 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,17707842 0,20653163 ! protein targeting to membrane GO:0006612 53 29 0,000 0,17707842 0,20642695 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,17707842 0,20632238 ! mismatch repair GO:0006298 34 29 0,000 0,17707842 0,20621791 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,17707842 0,20611355 ! muscle cell development GO:0055001 38 29 0,000 0,17707842 0,20600929 ! formation of primary germ layer GO:0001704 48 29 0,000 0,17707842 0,20590514 ! telencephalon development GO:0021537 52 29 0,000 0,17707842 0,2058011 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,17707842 0,20569716 ! eye morphogenesis GO:0048592 51 29 0,000 0,17707842 0,20559332 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,17707842 0,20548959 ! tissue homeostasis GO:0001894 42 29 0,000 0,17707842 0,20538597 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,18259506 0,21167774 ! collagen metabolic process GO:0032963 40 30 0,000 0,18259506 0,2115711 ! organic anion transport GO:0015711 51 30 0,000 0,18259506 0,21146457 ! cholesterol transport GO:0030301 46 30 0,000 0,18259506 0,21135814 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,18259506 0,21125183 ! spliceosome assembly GO:0000245 49 30 0,000 0,18259506 0,21114562 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,18259506 0,21103951 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,18259506 0,21093352 ! ceramide metabolic process GO:0006672 43 30 0,000 0,18259506 0,21082763 ! ovulation cycle GO:0042698 43 30 0,000 0,18259506 0,21072184 ! hindbrain development GO:0030902 45 30 0,000 0,18259506 0,21061616 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,18259506 0,21051059 ! adult locomotory behavior GO:0008344 47 30 0,000 0,18259506 0,21040513 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,18259506 0,21029977 ! response to heat GO:0009408 41 30 0,000 0,18259506 0,21019451 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,18259506 0,21008936 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,18259506 0,20998432 ! negative regulation of secretion GO:0051048 49 31 0,000 0,18807502 0,21617819 ! glial cell differentiation GO:0010001 55 31 0,000 0,18807502 0,21607021 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,18807502 0,21596233 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,18807502 0,21585457 ! odontogenesis GO:0042476 50 31 0,000 0,18807502 0,21574691 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,18807502 0,21563936 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,18807502 0,21553192 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,18807502 0,21542458 ! metanephros development GO:0001656 58 31 0,000 0,18807502 0,21531735 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,18807502 0,21521023 ! cell fate specification GO:0001708 37 31 0,000 0,18807502 0,21510321 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,18807502 0,2149963 ! RNA modification GO:0009451 40 31 0,000 0,18807502 0,2148895 ! regulation of muscle development GO:0048634 48 32 0,000 0,19351856 0,22099935 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,19351856 0,22088968 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,19351856 0,22078011 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,19351856 0,22067065 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,19351856 0,2205613 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 48 32 0,000 0,19351856 0,22045205 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,19351856 0,22034292 ! cytokine production GO:0001816 44 32 0,000 0,19351856 0,22023389 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,19351856 0,22012497 ! vesicle localization GO:0051648 47 32 0,000 0,19351856 0,22001616 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,19892592 0,22605218 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,19892592 0,22594055 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,19892592 0,22582903 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,19892592 0,22571762 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,19892592 0,22560632 ! actomyosin structure organization GO:0031032 43 33 0,000 0,19892592 0,22549513 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,19892592 0,22538404 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,19892592 0,22527307 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,19892592 0,22516221 ! female gonad development GO:0008585 49 33 0,000 0,19892592 0,22505146 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,19892592 0,22494081 ! positive regulation of cell development GO:0010720 54 33 0,000 0,19892592 0,22483028 ! lipid homeostasis GO:0055088 55 33 0,000 0,19892592 0,22471985 ! regulation of proteolysis GO:0030162 50 33 0,000 0,19892592 0,22460953 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,19892592 0,22449932 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,19892592 0,22438922 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,19892592 0,22427922 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,20429732 0,23022236 ! mRNA catabolic process GO:0006402 48 34 0,000 0,20429732 0,23010962 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,20429732 0,22999699 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,20429732 0,22988446 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,20429732 0,22977205 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,20429732 0,22965975 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,20429732 0,22954756 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,20429732 0,22943547 ! neuron migration GO:0001764 46 34 0,000 0,20429732 0,2293235 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,20429732 0,22921163 ! female gamete generation GO:0007292 43 34 0,000 0,20429732 0,22909988 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,20429732 0,22898823 ! polyol metabolic process GO:0019751 44 34 0,000 0,20429732 0,22887669 ! aerobic respiration GO:0009060 47 34 0,000 0,20429732 0,22876526 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,20429732 0,22865394 ! embryonic organ development GO:0048568 45 34 0,000 0,20429732 0,22854273 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,20429732 0,22843162 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,20963302 0,23428374 ! Notch signaling pathway GO:0007219 56 35 0,000 0,20963302 0,23416996 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,20963302 0,23405628 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,20963302 0,23394272 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,20963302 0,23382927 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,20963302 0,23371592 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,20963302 0,23360269 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,20963302 0,23348956 ! pigment metabolic process GO:0042440 61 35 0,000 0,20963302 0,23337655 ! protein homooligomerization GO:0051260 52 35 0,000 0,20963302 0,23326364 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,21493324 0,23904567 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,21493324 0,23893014 ! negative regulation of binding GO:0051100 58 36 0,000 0,21493324 0,23881471 ! organic ether metabolic process GO:0018904 46 36 0,000 0,21493324 0,2386994 ! tissue remodeling GO:0048771 62 36 0,000 0,21493324 0,23858419 ! neural tube development GO:0021915 50 36 0,000 0,21493324 0,2384691 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,21493324 0,23835412 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,21493324 0,23823925 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,21493324 0,23812449 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,21493324 0,23800985 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,22019822 0,24372276 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,22019822 0,24360553 ! ion transmembrane transport GO:0034220 56 37 0,000 0,22019822 0,24348841 ! regulation of protein secretion GO:0050708 51 37 0,000 0,22019822 0,24337141 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,22019822 0,24325452 ! gliogenesis GO:0042063 71 38 0,000 0,22542819 0,24891254 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,22542819 0,2487931 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,22542819 0,24867378 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,22542819 0,24855457 ! phagocytosis GO:0006909 60 38 0,000 0,22542819 0,24843547 ! mesenchymal cell development GO:0014031 64 38 0,000 0,22542819 0,24831649 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 0,000 0,22542819 0,24819762 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,23062338 0,25379606 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,23062338 0,25367469 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,23062338 0,25355343 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,23062338 0,25343228 ! male sex differentiation GO:0046661 53 39 0,000 0,23062338 0,25331125 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,23062338 0,25319034 ! chromatin remodeling GO:0006338 68 39 0,000 0,23062338 0,25306955 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,23062338 0,25294886 ! JNK cascade GO:0007254 54 39 0,000 0,23062338 0,2528283 ! developmental growth GO:0048589 62 39 0,000 0,23062338 0,25270785 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,23578402 0,25823964 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,23578402 0,25811673 ! regulation of tube size GO:0035150 60 40 0,000 0,23578402 0,25799393 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,23578402 0,25787125 ! inner ear development GO:0048839 57 40 0,000 0,23578402 0,25774869 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,23578402 0,25762624 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,23578402 0,25750391 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,23578402 0,2573817 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,24091034 0,26285284 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,24091034 0,2627282 ! striated muscle contraction GO:0006941 62 41 0,000 0,24091034 0,26260369 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,24091034 0,26247929 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,24091034 0,26235501 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,24600256 0,26777373 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,24600256 0,26764706 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,24600256 0,26752052 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,24600256 0,26739409 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,24600256 0,26726778 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,24600256 0,26714159 ! excretion GO:0007588 63 42 0,000 0,24600256 0,26701552 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,24600256 0,26688957 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,24600256 0,26676374 ! regulation of cell shape GO:0008360 78 42 0,000 0,24600256 0,26663803 ! neuromuscular process GO:0050905 79 43 0,000 0,25106092 0,27199252 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,25106092 0,27186446 ! tRNA processing GO:0008033 49 43 0,000 0,25106092 0,27173652 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,25106092 0,27160871 ! vesicle organization GO:0016050 79 43 0,000 0,25106092 0,27148101 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,25106092 0,27135343 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,25608562 0,27665427 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,25608562 0,27652438 ! glycolysis GO:0006096 53 44 0,000 0,25608562 0,27639462 ! regulation of ion transport GO:0043269 57 44 0,000 0,25608562 0,27626498 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,25608562 0,27613546 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,25608562 0,27600606 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,25608562 0,27587679 ! RNA catabolic process GO:0006401 64 45 0,000 0,26107691 0,28112214 ! regulation of translational initiation GO:0006446 64 45 0,000 0,26107691 0,28099059 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,26107691 0,28085916 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,26107691 0,28072786 ! cell recognition GO:0008037 58 45 0,000 0,26107691 0,28059668 ! cell maturation GO:0048469 60 45 0,000 0,26107691 0,28046562 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,26603498 0,28565848 ! cell redox homeostasis GO:0045454 63 46 0,000 0,26603498 0,28552518 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,26603498 0,28539201 ! regulation of ossification GO:0030278 71 46 0,000 0,26603498 0,28525896 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,26603498 0,28512603 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,27096008 0,2902693 ! viral infectious cycle GO:0019058 71 47 0,000 0,27096008 0,29013416 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,27096008 0,28999915 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,27096008 0,28986427 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,27096008 0,28972951 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,27096008 0,28959488 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,27096008 0,28946037 ! chloride transport GO:0006821 67 48 0,000 0,2758524 0,29454992 ! response to temperature stimulus GO:0009266 62 48 0,000 0,2758524 0,29441324 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,2758524 0,29427668 ! gastrulation GO:0007369 73 48 0,000 0,2758524 0,29414025 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,2758524 0,29400395 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,2758524 0,29386777 ! regulation of endocytosis GO:0030100 63 48 0,000 0,2758524 0,29373172 ! nuclear export GO:0051168 69 48 0,000 0,2758524 0,2935958 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,2758524 0,29346 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,28071217 0,29849191 ! sensory perception of smell GO:0007608 61 49 0,000 0,28071217 0,29835397 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,28071217 0,29821617 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,28071217 0,29807848 ! RNA elongation GO:0006354 62 49 0,000 0,28071217 0,29794093 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,28071217 0,2978035 ! germ cell development GO:0007281 68 49 0,000 0,28071217 0,2976662 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,28071217 0,29752903 ! maintenance of location GO:0051235 84 49 0,000 0,28071217 0,29739198 ! regulation of actin filament length GO:0030832 72 50 0,000 0,28553961 0,30236699 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,28553961 0,30222784 ! proton transport GO:0015992 75 50 0,000 0,28553961 0,30208882 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,28553961 0,30194993 ! positive regulation of secretion GO:0051047 71 51 0,000 0,29033492 0,30687974 ! hydrogen transport GO:0006818 77 51 0,000 0,29033492 0,30673878 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,29033492 0,30659794 ! adult behavior GO:0030534 80 51 0,000 0,29033492 0,30645724 ! transition metal ion transport GO:0000041 74 52 0,000 0,29509832 0,31134226 ! regulation of cellular component size GO:0032535 74 52 0,000 0,29509832 0,31119951 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,29509832 0,31105689 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,29983002 0,3158997 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,29983002 0,31575505 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,29983002 0,31561054 ! kidney development GO:0001822 90 53 0,000 0,29983002 0,31546617 ! amino acid transport GO:0006865 84 54 0,000 0,30453022 0,32026498 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,30453022 0,32011861 ! glucose catabolic process GO:0006007 66 54 0,000 0,30453022 0,31997237 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,30453022 0,31982626 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,30453022 0,31968029 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,30453022 0,31953445 ! exocytosis GO:0006887 74 55 0,000 0,30919914 0,32428547 ! mesoderm development GO:0007498 76 55 0,000 0,30919914 0,32413766 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,30919914 0,32398999 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,31844396 0,33352509 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,31844396 0,33337328 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,31844396 0,33322161 ! camera-type eye development GO:0043010 88 57 0,000 0,31844396 0,33307008 ! secondary metabolic process GO:0019748 84 57 0,000 0,31844396 0,33291868 ! developmental maturation GO:0021700 75 57 0,000 0,31844396 0,33276743 ! gonad development GO:0008406 79 57 0,000 0,31844396 0,33261631 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,32302026 0,33724312 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,3275661 0,34183395 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,3275661 0,34167892 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,33208166 0,34623202 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,33208166 0,34607514 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,33208166 0,3459184 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,33208166 0,34576181 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,33656717 0,35027352 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,33656717 0,3501151 ! urogenital system development GO:0001655 101 61 0,000 0,33656717 0,34995682 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,33656717 0,34979868 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,33656717 0,34964069 ! extracellular matrix organization GO:0030198 103 61 0,000 0,33656717 0,34948284 ! amine catabolic process GO:0009310 90 62 0,000 0,3410228 0,35394966 ! neurotransmitter transport GO:0006836 81 62 0,000 0,3410228 0,35379001 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,3410228 0,3536305 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,34544877 0,35805866 ! appendage morphogenesis GO:0035107 93 64 0,000 0,34984526 0,3624523 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,34984526 0,36228911 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,34984526 0,36212606 ! hexose catabolic process GO:0019320 82 64 0,000 0,34984526 0,36196316 ! reproductive structure development GO:0048608 90 65 0,000 0,35421248 0,36631686 ! appendage development GO:0048736 94 65 0,000 0,35421248 0,36615222 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,35421248 0,36598773 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,35421248 0,36582339 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,35421248 0,3656592 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,3585506 0,36997146 ! antigen processing and presentation GO:0019882 96 66 0,000 0,3585506 0,36980555 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,3585506 0,3696398 ! regulation of immune effector process GO:0002697 101 66 0,000 0,3585506 0,36947419 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,36285983 0,37374725 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,36285983 0,37357995 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,36714036 0,37781782 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,36714036 0,37764885 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,36714036 0,37748003 ! rhythmic process GO:0048511 105 68 0,000 0,36714036 0,37731136 ! inorganic anion transport GO:0015698 93 68 0,000 0,36714036 0,37714285 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,37139238 0,38134039 ! amine transport GO:0015837 101 70 0,000 0,37561606 0,38550511 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,37561606 0,38533316 ! muscle cell differentiation GO:0042692 104 71 0,000 0,37981161 0,38946354 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,37981161 0,38928998 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,37981161 0,38911658 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,38397921 0,39321113 ! regulation of blood pressure GO:0008217 107 73 0,000 0,38811904 0,39727361 ! tube morphogenesis GO:0035239 118 73 0,000 0,38811904 0,39709688 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,38811904 0,39692032 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,38811904 0,39674391 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,39223129 0,40076942 ! digestion GO:0007586 97 74 0,000 0,39223129 0,40059146 ! response to nutrient GO:0007584 104 75 0,000 0,39631613 0,40458371 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,39631613 0,40440421 ! amine biosynthetic process GO:0009309 97 76 0,000 0,40037375 0,40836347 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,40037375 0,40818246 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,40440433 0,41210898 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,40440433 0,41192647 ! sex differentiation GO:0007548 105 77 0,000 0,40440433 0,41174412 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,40440433 0,41156193 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,40440433 0,4113799 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,40840805 0,41526901 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,40840805 0,41508551 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,41238508 0,41894244 ! cellular respiration GO:0045333 107 79 0,000 0,41238508 0,41875748 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,41238508 0,41857267 ! regulation of lyase activity GO:0051339 133 79 0,000 0,41238508 0,41838804 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,41238508 0,41820356 ! alcohol catabolic process GO:0046164 104 80 0,000 0,4163356 0,42202375 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,4163356 0,42183783 ! forebrain development GO:0030900 131 80 0,000 0,4163356 0,42165208 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,42025979 0,42543905 ! regulation of neurological system process GO:0031644 122 81 0,000 0,42025979 0,42525188 ! vitamin metabolic process GO:0006766 103 81 0,000 0,42025979 0,42506487 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,42802986 0,43273349 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,42802986 0,43254336 ! sterol metabolic process GO:0016125 120 84 0,000 0,43187609 0,43623847 ! rRNA metabolic process GO:0016072 107 85 0,000 0,43569667 0,43990445 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,43949178 0,44354151 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,44326158 0,44714984 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,44326158 0,44695381 ! female pregnancy GO:0007565 130 87 0,000 0,44326158 0,44675795 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,44700624 0,4503348 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,44700624 0,45013763 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,44700624 0,44994064 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,45072593 0,45348628 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,45072593 0,45328799 ! hormone metabolic process GO:0042445 121 90 0,000 0,45442081 0,45680414 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,46173681 0,46395572 ! DNA recombination GO:0006310 146 92 0,000 0,46173681 0,46375312 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,46535824 0,46718636 ! electron transport chain GO:0022900 123 94 0,000 0,46895552 0,47059237 ! angiogenesis GO:0001525 149 95 0,000 0,4725288 0,47397132 ! carboxylic acid transport GO:0046942 147 95 0,000 0,4725288 0,47376471 GO:0015849|organic acid transport, ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,47607824 0,47711545 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,479604 0,48043955 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,479604 0,48023039 ! regulation of translation GO:0006417 151 100 0,000 0,49004075 0,49046724 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,49004075 0,4902539 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,49004075 0,49004075