pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6467-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! elastic fiber assembly GO:0048251 13 9 6,000 1,398E-16 3,216E-13 ! collagen metabolic process GO:0032963 40 30 6,000 7,479E-12 8,6E-09 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 6,000 1,557E-11 1,194E-08 ! multicellular organismal metabolic process GO:0044236 50 39 6,000 5,517E-11 3,172E-08 ! extracellular matrix organization GO:0030198 103 61 6,000 1,476E-09 6,789E-07 ! aging GO:0007568 79 52 5,000 2,277E-08 8,73E-06 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 4,000 2,5E-08 8,214E-06 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 2,592E-08 7,452E-06 ! extracellular structure organization GO:0043062 156 99 6,000 4,552E-08 1,163E-05 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 4,000 1,036E-07 2,382E-05 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 3,825E-07 7,997E-05 ! response to UV GO:0009411 75 46 4,000 4,943E-07 9,475E-05 ! male meiosis GO:0007140 7 6 2,000 7,631E-07 1,35E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 7,631E-07 1,254E-04 ! ER overload response GO:0006983 7 6 2,000 7,631E-07 1,17E-04 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 7,631E-07 1,097E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 8,361E-07 1,131E-04 ! angiogenesis GO:0001525 149 95 5,000 8,675E-07 1,108E-04 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 1,332E-06 1,613E-04 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 2,126E-06 2,445E-04 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 2,000 4,534E-06 4,966E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! response to X-ray GO:0010165 16 10 2,000 4,534E-06 4,74E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 4,534E-06 4,534E-04 ! response to gamma radiation GO:0010332 20 12 2,000 8,272E-06 7,927E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 1,044E-05 9,609E-04 ! JAK-STAT cascade GO:0007259 53 40 3,000 1,044E-05 9,24E-04 ! inositol metabolic process GO:0006020 20 14 2,000 1,362E-05 1,16E-03 ! cardiac muscle tissue development GO:0048738 23 15 2,000 1,698E-05 1,395E-03 ! response to light stimulus GO:0009416 153 96 4,000 1,934E-05 1,533E-03 ! endothelial cell migration GO:0043542 22 16 2,000 2,085E-05 1,598E-03 ! lipid modification GO:0030258 73 50 3,000 2,566E-05 1,903E-03 ! cell aging GO:0007569 32 21 2,000 4,892E-05 3,516E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 4,892E-05 3,409E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 4,892E-05 3,309E-03 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 5,295E-05 3,48E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 5,65E-05 3,61E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 5,65E-05 3,512E-03 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 5,65E-05 3,42E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 6,482E-05 3,823E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 6,482E-05 3,727E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 6,482E-05 3,636E-03 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 9,447E-05 5,173E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 1,06E-04 5,671E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,151E-04 6,015E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,151E-04 5,881E-03 ! positive regulation of neuroblast proliferation GO:0002052 8 5 1,000 1,151E-04 5,753E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 1,151E-04 5,631E-03 ! centrosome duplication GO:0051298 5 5 1,000 1,151E-04 5,514E-03 ! response to UV-C GO:0010225 6 5 1,000 1,151E-04 5,401E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 1,151E-04 5,293E-03 ! response to unfolded protein GO:0006986 99 76 3,000 1,337E-04 6,031E-03 ! response to protein stimulus GO:0051789 111 81 3,000 1,712E-04 7,573E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 1,722E-04 7,474E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 1,722E-04 7,335E-03 ! prostate gland development GO:0030850 9 6 1,000 1,722E-04 7,202E-03 ! mRNA stabilization GO:0048255 15 6 1,000 1,722E-04 7,073E-03 GO:0043489|RNA stabilization, ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,722E-04 6,949E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 1,722E-04 6,83E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,722E-04 6,714E-03 ! blastocyst growth GO:0001832 15 6 1,000 1,722E-04 6,602E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 1,722E-04 6,494E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 1,776E-04 6,588E-03 ! regulation of protein stability GO:0031647 48 32 2,000 1,776E-04 6,484E-03 ! ossification GO:0001503 134 82 3,000 1,795E-04 6,452E-03 GO:0060348|bone development, ! negative regulation of cell adhesion GO:0007162 67 33 2,000 1,949E-04 6,896E-03 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 2,132E-04 7,43E-03 ! polyol metabolic process GO:0019751 44 34 2,000 2,132E-04 7,319E-03 ! cell cycle arrest GO:0007050 150 86 3,000 2,158E-04 7,298E-03 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 2,326E-04 7,754E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,406E-04 7,905E-03 ! regulation of defense response to virus by virus GO:0050690 16 7 1,000 2,406E-04 7,793E-03 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 2,406E-04 7,685E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 2,406E-04 7,58E-03 ! T-helper 1 type immune response GO:0042088 11 7 1,000 2,406E-04 7,477E-03 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 1,000 2,406E-04 7,378E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 2,406E-04 7,281E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 2,406E-04 7,186E-03 ! response to tumor cell GO:0002347 12 7 1,000 2,406E-04 7,094E-03 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 2,796E-04 8,14E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 3,201E-04 9,202E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 3,201E-04 9,088E-03 ! induction of positive chemotaxis GO:0050930 14 8 1,000 3,201E-04 8,977E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 3,201E-04 8,869E-03 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 1,000 3,201E-04 8,764E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 3,201E-04 8,661E-03 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 3,201E-04 8,56E-03 ! multicellular organism growth GO:0035264 14 8 1,000 3,201E-04 8,461E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 3,201E-04 8,365E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 3,201E-04 8,271E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 3,201E-04 8,179E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 3,217E-04 8,13E-03 ! double-strand break repair GO:0006302 67 40 2,000 3,469E-04 8,673E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 4,011E-04 9,921E-03 ! lung alveolus development GO:0048286 17 9 1,000 4,106E-04 0,01004664 ! substrate-bound cell migration GO:0006929 10 9 1,000 4,106E-04 9,941E-03 ! oocyte differentiation GO:0009994 12 9 1,000 4,106E-04 9,837E-03 GO:0048599|oocyte development, ! localization within membrane GO:0051668 15 9 1,000 4,106E-04 9,736E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 4,302E-04 0,01009587 ! negative regulation of cell migration GO:0030336 92 44 2,000 4,605E-04 0,01069905 ! positive regulation of cell cycle GO:0045787 77 45 2,000 4,922E-04 0,01132101 ! regulation of B cell proliferation GO:0030888 15 10 1,000 5,121E-04 0,01166211 ! blood vessel remodeling GO:0001974 21 10 1,000 5,121E-04 0,01154778 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 5,121E-04 0,01143566 ! regulation of bone resorption GO:0045124 24 10 1,000 5,121E-04 0,0113257 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 5,121E-04 0,01121784 ! regulation of DNA replication GO:0006275 75 48 2,000 5,956E-04 0,01292316 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 6,245E-04 0,01342471 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 6,245E-04 0,01330041 GO:0000725|recombinational repair, ! regulation of positive chemotaxis GO:0050926 17 11 1,000 6,245E-04 0,01317839 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 6,245E-04 0,01305859 ! regulation of mRNA processing GO:0050684 18 11 1,000 6,245E-04 0,01294094 ! regulation of intracellular pH GO:0051453 17 11 1,000 6,245E-04 0,0128254 ! nitric oxide metabolic process GO:0046209 14 11 1,000 6,245E-04 0,0127119 GO:0006809|nitric oxide biosynthetic process, ! regulation of leukocyte migration GO:0002685 24 11 1,000 6,245E-04 0,01260039 ! regulation of intracellular transport GO:0032386 78 49 2,000 6,329E-04 0,01265777 ! germ cell development GO:0007281 68 49 2,000 6,329E-04 0,01254865 ! positive regulation of cell migration GO:0030335 92 51 2,000 7,119E-04 0,01399443 ! negative regulation of cell motion GO:0051271 104 51 2,000 7,119E-04 0,01387584 ! cartilage condensation GO:0001502 18 12 1,000 7,478E-04 0,01445318 ! regulation of mRNA stability GO:0043488 27 12 1,000 7,478E-04 0,01433274 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 7,478E-04 0,01421428 ! nucleotide-excision repair GO:0006289 64 52 2,000 7,536E-04 0,01420795 ! regulation of bone remodeling GO:0046850 90 53 2,000 7,969E-04 0,01490166 ! regulation of tissue remodeling GO:0034103 91 54 2,000 8,417E-04 0,01561294 ! regulation of cellular pH GO:0030641 20 13 1,000 8,818E-04 0,01622525 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 8,818E-04 0,01609648 ! regulation of RNA stability GO:0043487 28 13 1,000 8,818E-04 0,01596974 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 9,361E-04 0,01682109 ! positive regulation of cell motion GO:0051272 99 56 2,000 9,361E-04 0,01669069 ! regulation of S phase GO:0033261 18 14 1,000 1,027E-03 0,01816125 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,027E-03 0,01802261 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 1,027E-03 0,01788608 ! cardiac muscle contraction GO:0060048 23 14 1,000 1,027E-03 0,0177516 ! regulation of defense response to virus GO:0050688 24 14 1,000 1,027E-03 0,01761912 ! cellular response to starvation GO:0009267 21 14 1,000 1,027E-03 0,01748861 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,027E-03 0,01736002 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,027E-03 0,0172333 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 1,027E-03 0,01710842 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,027E-03 0,01698534 ! lipid phosphorylation GO:0046834 23 15 1,000 1,182E-03 0,01941556 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 1,182E-03 0,01927786 ! centrosome cycle GO:0007098 16 15 1,000 1,182E-03 0,0191421 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 1,182E-03 0,01900824 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 1,182E-03 0,01887624 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,182E-03 0,01874606 ! meiosis GO:0007126 96 61 2,000 1,201E-03 0,0189155 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of cell growth GO:0030308 106 62 2,000 1,259E-03 0,01969414 ! meiotic cell cycle GO:0051321 97 62 2,000 1,259E-03 0,01956107 ! oogenesis GO:0048477 23 16 1,000 1,348E-03 0,02080295 ! cell cycle checkpoint GO:0000075 108 64 2,000 1,38E-03 0,02115879 ! negative regulation of cell size GO:0045792 108 64 2,000 1,38E-03 0,02101867 ! reproductive structure development GO:0048608 90 65 2,000 1,443E-03 0,02183758 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,524E-03 0,02290967 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 1,524E-03 0,0227609 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 1,524E-03 0,02261406 ! peptidyl-serine modification GO:0018209 27 17 1,000 1,524E-03 0,0224691 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 1,524E-03 0,02232598 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 1,711E-03 0,02490275 ! heart process GO:0003015 27 18 1,000 1,711E-03 0,02474613 GO:0060047|heart contraction, ! cellular response to nutrient levels GO:0031669 27 18 1,000 1,711E-03 0,02459146 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 1,711E-03 0,02443872 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 1,908E-03 0,02708544 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 1,908E-03 0,02691927 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 1,908E-03 0,02675513 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 1,908E-03 0,02659298 ! response to starvation GO:0042594 30 19 1,000 1,908E-03 0,02643278 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 1,908E-03 0,0262745 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,908E-03 0,0261181 ! microtubule-based transport GO:0010970 37 20 1,000 2,115E-03 0,02878484 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 2,115E-03 0,02861552 ! positive regulation of locomotion GO:0040017 35 20 1,000 2,115E-03 0,02844818 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 2,115E-03 0,02828278 ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,115E-03 0,02811929 ! negative regulation of growth GO:0045926 123 75 2,000 2,177E-03 0,02878274 ! regulation of protein transport GO:0051223 114 76 2,000 2,261E-03 0,02972213 GO:0070201|regulation of establishment of protein localization, ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,333E-03 0,03048217 ! regulation of chemotaxis GO:0050920 36 21 1,000 2,333E-03 0,03030996 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 2,333E-03 0,03013967 ! regulation of multi-organism process GO:0043900 32 21 1,000 2,333E-03 0,0299713 ! gland development GO:0048732 148 77 2,000 2,347E-03 0,02999511 ! sex differentiation GO:0007548 105 77 2,000 2,347E-03 0,02982939 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 2,56E-03 0,03235359 ! vasculogenesis GO:0001570 33 22 1,000 2,56E-03 0,03217679 ! microtubule organizing center organization GO:0031023 28 22 1,000 2,56E-03 0,03200192 GO:0051297|centrosome organization, ! regulation of behavior GO:0050795 38 22 1,000 2,56E-03 0,03182893 ! blastocyst development GO:0001824 37 22 1,000 2,56E-03 0,03165781 ! protein tetramerization GO:0051262 39 22 1,000 2,56E-03 0,03148852 ! embryonic pattern specification GO:0009880 31 23 1,000 2,798E-03 0,03422846 ! osteoblast differentiation GO:0001649 40 23 1,000 2,798E-03 0,03404735 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 2,798E-03 0,03386816 ! regulation of response to biotic stimulus GO:0002831 35 23 1,000 2,798E-03 0,03369084 ! regulation of cell adhesion GO:0030155 159 83 2,000 2,906E-03 0,03481064 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 3,006E-03 0,0358259 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 3,045E-03 0,03610564 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 3,045E-03 0,03592048 ! mitochondrial membrane organization GO:0007006 39 24 1,000 3,045E-03 0,03573721 ! response to toxin GO:0009636 38 24 1,000 3,045E-03 0,0355558 ! negative regulation of cell development GO:0010721 56 24 1,000 3,045E-03 0,03537623 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 3,045E-03 0,03519846 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 3,045E-03 0,03502247 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 3,045E-03 0,03484823 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 3,045E-03 0,03467571 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 3,109E-03 0,03522172 ! regulation of protein localization GO:0032880 132 85 2,000 3,109E-03 0,03504906 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 3,213E-03 0,03605125 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 3,303E-03 0,0368778 GO:0045936|negative regulation of phosphate metabolic process, ! interphase GO:0051325 159 88 2,000 3,429E-03 0,03809802 ! regulation of neurogenesis GO:0050767 153 89 2,000 3,54E-03 0,0391425 ! reproductive developmental process GO:0003006 127 89 2,000 3,54E-03 0,03895522 ! regulation of pH GO:0006885 36 26 1,000 3,57E-03 0,03910376 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 3,57E-03 0,03891843 ! negative regulation of protein transport GO:0051224 49 27 1,000 3,847E-03 0,04174163 ! cell fate commitment GO:0045165 141 92 2,000 3,886E-03 0,04196196 ! erythrocyte differentiation GO:0030218 38 28 1,000 4,134E-03 0,04443448 ! response to organic cyclic substance GO:0014070 47 28 1,000 4,134E-03 0,04422781 ! BMP signaling pathway GO:0030509 40 28 1,000 4,134E-03 0,04402305 ! positive regulation of catabolic process GO:0009896 40 28 1,000 4,134E-03 0,04382018 ! regulation of B cell activation GO:0050864 42 28 1,000 4,134E-03 0,04361917 ! in utero embryonic development GO:0001701 147 96 2,000 4,379E-03 0,04598707 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 4,379E-03 0,04577804 ! tissue homeostasis GO:0001894 42 29 1,000 4,431E-03 0,04611264 GO:0048871|multicellular organismal homeostasis, ! spindle organization GO:0007051 37 30 1,000 4,737E-03 0,04907575 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 4,737E-03 0,04885568 ! DNA damage checkpoint GO:0000077 53 31 1,000 5,052E-03 0,05187764 ! mammary gland development GO:0030879 57 31 1,000 5,052E-03 0,05164707 ! xenobiotic metabolic process GO:0006805 44 31 1,000 5,052E-03 0,05141854 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 5,052E-03 0,05119203 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 5,377E-03 0,0542459 ! calcium-mediated signaling GO:0019722 50 32 1,000 5,377E-03 0,05400902 ! female gonad development GO:0008585 49 33 1,000 5,712E-03 0,05711778 ! positive regulation of cell development GO:0010720 54 33 1,000 5,712E-03 0,05687052 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 5,712E-03 0,05662538 ! cytokinesis GO:0000910 52 33 1,000 5,712E-03 0,05638236 ! DNA integrity checkpoint GO:0031570 57 34 1,000 6,055E-03 0,05951926 ! erythrocyte homeostasis GO:0034101 45 34 1,000 6,055E-03 0,05926599 ! female gamete generation GO:0007292 43 34 1,000 6,055E-03 0,05901486 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 6,055E-03 0,05876586 ! glycogen metabolic process GO:0005977 48 35 1,000 6,408E-03 0,06192929 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 6,408E-03 0,06167017 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! tissue remodeling GO:0048771 62 36 1,000 6,77E-03 0,06488304 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 6,77E-03 0,06461382 GO:0046660|female sex differentiation, ! response to xenobiotic stimulus GO:0009410 50 36 1,000 6,77E-03 0,06434682 ! glucan metabolic process GO:0044042 49 36 1,000 6,77E-03 0,06408202 GO:0006073|cellular glucan metabolic process, ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 7,522E-03 0,07090219 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 7,911E-03 0,07426647 ! developmental growth GO:0048589 62 39 1,000 7,911E-03 0,07396457 ! cell growth GO:0016049 61 39 1,000 7,911E-03 0,07366512 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 8,309E-03 0,07706022 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 8,309E-03 0,07675074 ! T cell differentiation GO:0030217 65 40 1,000 8,309E-03 0,07644374 ! B cell differentiation GO:0030183 62 40 1,000 8,309E-03 0,07613918 ! positive regulation of protein transport GO:0051222 55 40 1,000 8,309E-03 0,07583705 ! energy reserve metabolic process GO:0006112 59 41 1,000 8,716E-03 0,07923693 ! striated muscle contraction GO:0006941 62 41 1,000 8,716E-03 0,07892497 ! mitochondrial transport GO:0006839 60 42 1,000 9,132E-03 0,08236533 ! regulation of cell shape GO:0008360 78 42 1,000 9,132E-03 0,08204359 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 9,556E-03 0,08552311 ! activation of caspase activity GO:0006919 65 43 1,000 9,556E-03 0,08519163 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 9,556E-03 0,0848627 ! response to insulin stimulus GO:0032868 63 43 1,000 9,556E-03 0,08453631 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 9,989E-03 0,08802928 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,01043114 0,09157107 ! cell maturation GO:0048469 60 45 1,000 0,01043114 0,09122289 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,01043114 0,09087735 ! regulation of ossification GO:0030278 71 46 1,000 0,01088141 0,09444239 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,01134015 0,0980539 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,01134015 0,09768666 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,01134015 0,09732216 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,0118073 0,10095462 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,0118073 0,10058072 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,01228281 0,10424524 ! cartilage development GO:0051216 70 49 1,000 0,01228281 0,10386198 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01325864 0,11170279 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,01325864 0,11129512 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01375884 0,1150739 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,01426715 0,11889289 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01478351 0,12275115 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01478351 0,1223096 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 0,01638031 0,1350348 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,01638031 0,13455254 ! developmental maturation GO:0021700 75 57 1,000 0,01638031 0,1340737 ! gonad development GO:0008406 79 57 1,000 0,01638031 0,13359826 ! negative regulation of kinase activity GO:0033673 100 58 1,000 0,01692828 0,1375797 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01704506 0,13804094 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01704506 0,13755658 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01704506 0,13707562 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01704506 0,136598 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01704506 0,1361237 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01704506 0,13565269 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01704506 0,13518492 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01704506 0,13472037 ! sleep GO:0030431 11 5 0,000 0,01704506 0,134259 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01704506 0,13380077 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01704506 0,13334567 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01704506 0,13289365 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01704506 0,13244468 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01704506 0,13199874 ! tongue development GO:0043586 6 5 0,000 0,01704506 0,13155579 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01704506 0,13111581 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01704506 0,13067876 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01704506 0,13024461 ! cobalt ion transport GO:0006824 9 5 0,000 0,01704506 0,12981333 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01704506 0,12938491 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01704506 0,1289593 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01704506 0,12853648 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01704506 0,12811643 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01704506 0,12769911 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01704506 0,1272845 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01704506 0,12687258 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01704506 0,12646331 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01704506 0,12605668 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01704506 0,12565265 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01704506 0,1252512 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01704506 0,12485231 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01704506 0,12445596 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01704506 0,12406211 ! malate metabolic process GO:0006108 7 5 0,000 0,01704506 0,12367075 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01704506 0,12328184 ! behavioral response to pain GO:0048266 7 5 0,000 0,01704506 0,12289538 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01704506 0,12251133 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01704506 0,12212968 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01704506 0,12175039 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01704506 0,12137346 ! mating behavior GO:0007617 6 5 0,000 0,01704506 0,12099885 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01704506 0,12062654 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01704506 0,12025652 ! rhythmic behavior GO:0007622 12 5 0,000 0,01704506 0,11988877 ! copulation GO:0007620 7 5 0,000 0,01704506 0,11952325 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01704506 0,11915996 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01704506 0,11879887 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01704506 0,11843996 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01704506 0,11808321 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01704506 0,11772861 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01704506 0,11737613 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01704506 0,11702575 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01704506 0,11667746 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01704506 0,11633124 ! response to protozoan GO:0001562 9 5 0,000 0,01704506 0,11598706 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01704506 0,11564492 ! lymph vessel development GO:0001945 7 5 0,000 0,01704506 0,11530478 ! endochondral ossification GO:0001958 12 5 0,000 0,01704506 0,11496665 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01704506 0,11463049 ! parathyroid gland development GO:0060017 8 5 0,000 0,01704506 0,11429629 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01704506 0,11396403 ! anagen GO:0042640 6 5 0,000 0,01704506 0,1136337 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01704506 0,11330528 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01704506 0,11297875 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01704506 0,1126541 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01704506 0,11233131 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01704506 0,11201036 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01704506 0,11169124 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01704506 0,11137394 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01704506 0,11105843 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01704506 0,11074471 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01704506 0,11043275 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01704506 0,11012255 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01704506 0,10981408 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01704506 0,10950734 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01704506 0,1092023 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01704506 0,10889896 ! ovulation GO:0030728 6 5 0,000 0,01704506 0,1085973 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01704506 0,10829731 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01704506 0,10799897 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01704506 0,10770227 ! response to pH GO:0009268 9 5 0,000 0,01704506 0,1074072 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01704506 0,10711373 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01704506 0,10682187 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01704506 0,10653159 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01704506 0,10624289 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01704506 0,10595575 ! polyol catabolic process GO:0046174 7 5 0,000 0,01704506 0,10567015 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01704506 0,10538609 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01704506 0,10510356 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01704506 0,10482253 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01704506 0,104543 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01704506 0,10426496 ! urea metabolic process GO:0019627 6 5 0,000 0,01704506 0,1039884 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01704506 0,1037133 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01704506 0,10343965 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01704506 0,10316744 ! neutrophil activation GO:0042119 5 5 0,000 0,01704506 0,10289666 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01704506 0,10262729 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01704506 0,10235934 ! response to food GO:0032094 5 5 0,000 0,01704506 0,10209278 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01704506 0,1018276 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01704506 0,1015638 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01704506 0,10130136 ! forebrain neuron development GO:0021884 7 5 0,000 0,01704506 0,10104027 ! melanosome organization GO:0032438 7 5 0,000 0,01704506 0,10078053 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01704506 0,10052212 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01704506 0,10026503 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01704506 0,10000925 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01704506 0,09975478 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01704506 0,09950159 ! nucleoside transport GO:0015858 6 5 0,000 0,01704506 0,09924969 ! nucleoside salvage GO:0043174 7 5 0,000 0,01704506 0,09899906 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01704506 0,09874969 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01704506 0,09850157 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01704506 0,0982547 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01704506 0,09800907 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01704506 0,09776465 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01704506 0,09752146 ! depyrimidination GO:0045008 8 5 0,000 0,01704506 0,09727947 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01704506 0,09703868 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01704506 0,09679908 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01704506 0,09656066 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01704506 0,09632341 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01704506 0,09608732 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01704506 0,09585239 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01704506 0,0956186 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01704506 0,09538595 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01704506 0,09515443 ! monocyte differentiation GO:0030224 8 5 0,000 0,01704506 0,09492404 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01704506 0,09469475 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01704506 0,09446657 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01704506 0,09423949 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01704506 0,09401349 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01704506 0,09378858 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01704506 0,09356474 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01704506 0,09334197 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01704506 0,09312025 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01704506 0,09289959 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01704506 0,09267997 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01704506 0,09246138 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01704506 0,09224383 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01704506 0,09202729 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01704506 0,09181177 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01704506 0,09159726 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01704506 0,09138375 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01704506 0,09117122 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01704506 0,09095969 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01704506 0,09074914 ! neural tube patterning GO:0021532 6 5 0,000 0,01704506 0,09053955 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01704506 0,09033094 ! histone demethylation GO:0016577 9 5 0,000 0,01704506 0,09012328 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01704506 0,08991657 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01704506 0,08971082 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01704506 0,089506 ! enteric nervous system development GO:0048484 8 5 0,000 0,01704506 0,08930211 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01704506 0,08909915 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01704506 0,08889711 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01704506 0,08869599 ! transcription termination GO:0006353 8 5 0,000 0,01704506 0,08849577 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01704506 0,08829646 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01704506 0,08809804 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01704506 0,08790051 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01704506 0,08770386 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01704506 0,0875081 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01704506 0,0873132 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01704506 0,08711917 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01704506 0,086926 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01704506 0,08673369 ! apical protein localization GO:0045176 6 5 0,000 0,01704506 0,08654222 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01704506 0,0863516 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01704506 0,08616182 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01704506 0,08597287 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01704506 0,08578474 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01704506 0,08559744 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01704506 0,08541095 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01704506 0,08522528 ! glial cell migration GO:0008347 10 5 0,000 0,01704506 0,0850404 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01704506 0,08485633 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01704506 0,08467306 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01704506 0,08449057 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01704506 0,08430887 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01704506 0,08412795 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01704506 0,08394781 ! neural plate development GO:0001840 6 5 0,000 0,01704506 0,08376843 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01704506 0,08358982 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01704506 0,08341197 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01704506 0,08323488 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01704506 0,08305853 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01704506 0,08288293 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01704506 0,08270807 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01704506 0,08253395 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01704506 0,08236056 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01704506 0,0821879 ! spindle assembly GO:0051225 5 5 0,000 0,01704506 0,08201596 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01704506 0,08184473 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01704506 0,08167422 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01704506 0,08150442 ! organ regeneration GO:0031100 7 5 0,000 0,01704506 0,08133532 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01704506 0,08116693 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01704506 0,08099923 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01704506 0,08083222 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01704506 0,0806659 GO:0055081|anion homeostasis, ! lung development GO:0030324 94 59 1,000 0,01748402 0,08257339 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,01748402 0,08240419 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,01804745 0,08488576 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,01804745 0,08471253 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,01861853 0,0872151 ! urogenital system development GO:0001655 101 61 1,000 0,01861853 0,08703783 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,01861853 0,08686128 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,01861853 0,08668545 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,01861853 0,08651033 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,01861853 0,08633591 ! respiratory tube development GO:0030323 99 62 1,000 0,01919719 0,0888401 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,01978338 0,09136901 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01978338 0,0911859 ! respiratory system development GO:0060541 100 64 1,000 0,02037704 0,09373437 ! adaptive immune response GO:0002250 94 64 1,000 0,02037704 0,09354727 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! tRNA transcription GO:0009304 11 6 0,000 0,02041962 0,09355603 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02041962 0,09337004 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02041962 0,09318478 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02041962 0,09300026 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02041962 0,09281646 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02041962 0,09263339 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02041962 0,09245104 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02041962 0,09226941 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02041962 0,09208849 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02041962 0,09190828 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02041962 0,09172877 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02041962 0,09154996 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02041962 0,09137185 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02041962 0,09119443 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02041962 0,09101769 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02041962 0,09084164 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02041962 0,09066627 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02041962 0,09049158 ! neuron adhesion GO:0007158 9 6 0,000 0,02041962 0,09031756 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,02041962 0,0901442 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02041962 0,08997151 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02041962 0,08979948 ! signal peptide processing GO:0006465 8 6 0,000 0,02041962 0,08962811 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02041962 0,08945739 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02041962 0,08928732 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02041962 0,08911789 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02041962 0,08894911 ! opsonization GO:0008228 8 6 0,000 0,02041962 0,08878096 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02041962 0,08861345 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02041962 0,08844657 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02041962 0,08828032 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02041962 0,08811469 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02041962 0,08794968 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02041962 0,08778529 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02041962 0,08762151 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02041962 0,08745834 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02041962 0,08729578 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02041962 0,08713382 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02041962 0,08697246 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02041962 0,0868117 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02041962 0,08665153 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02041962 0,08649195 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02041962 0,08633296 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02041962 0,08617455 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02041962 0,08601672 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02041962 0,08585947 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02041962 0,08570279 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02041962 0,08554668 ! thymic T cell selection GO:0045061 12 6 0,000 0,02041962 0,08539114 ! protein lipoylation GO:0009249 10 6 0,000 0,02041962 0,08523617 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02041962 0,08508176 ! pigment granule organization GO:0048753 11 6 0,000 0,02041962 0,0849279 ! drug transport GO:0015893 6 6 0,000 0,02041962 0,0847746 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02041962 0,08462185 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02041962 0,08446966 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02041962 0,08431801 ! histidine metabolic process GO:0006547 6 6 0,000 0,02041962 0,0841669 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02041962 0,08401633 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02041962 0,0838663 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02041962 0,08371681 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02041962 0,08356785 ! adenohypophysis development GO:0021984 10 6 0,000 0,02041962 0,08341941 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02041962 0,08327151 ! hyperosmotic response GO:0006972 8 6 0,000 0,02041962 0,08312412 ! microtubule nucleation GO:0007020 10 6 0,000 0,02041962 0,08297726 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02041962 0,08283092 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02041962 0,08268509 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02041962 0,08253977 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02041962 0,08239496 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02041962 0,08225066 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02041962 0,08210687 ! response to dietary excess GO:0002021 7 6 0,000 0,02041962 0,08196358 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02041962 0,08182078 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02041962 0,08167849 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02041962 0,08153668 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02041962 0,08139537 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02041962 0,08125455 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02041962 0,08111421 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02041962 0,08097436 ! neuron apoptosis GO:0051402 8 6 0,000 0,02041962 0,08083499 ! organic alcohol transport GO:0015850 9 6 0,000 0,02041962 0,0806961 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02041962 0,08055768 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02041962 0,08041974 ! male sex determination GO:0030238 9 6 0,000 0,02041962 0,08028227 ! carnitine transport GO:0015879 8 6 0,000 0,02041962 0,08014527 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02041962 0,08000874 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02041962 0,07987267 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02041962 0,07973706 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02041962 0,07960191 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02041962 0,07946722 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02041962 0,07933299 ! parturition GO:0007567 12 6 0,000 0,02041962 0,07919921 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02041962 0,07906587 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02041962 0,07893299 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02041962 0,07880055 ! spindle checkpoint GO:0031577 14 6 0,000 0,02041962 0,07866856 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02041962 0,07853701 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02041962 0,07840589 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02041962 0,07827522 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02041962 0,07814497 ! macrophage differentiation GO:0030225 10 6 0,000 0,02041962 0,07801516 ! astrocyte development GO:0014002 14 6 0,000 0,02041962 0,07788579 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02041962 0,07775684 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02041962 0,07762831 ! interaction with symbiont GO:0051702 8 6 0,000 0,02041962 0,07750021 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02041962 0,07737254 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02041962 0,07724528 ! eating behavior GO:0042755 6 6 0,000 0,02041962 0,07711844 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02041962 0,07699202 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02041962 0,07686601 ! response to copper ion GO:0046688 9 6 0,000 0,02041962 0,07674041 ! DNA topological change GO:0006265 8 6 0,000 0,02041962 0,07661522 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02041962 0,07649044 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02041962 0,07636606 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02041962 0,07624209 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02041962 0,07611852 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02041962 0,07599535 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02041962 0,07587258 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02041962 0,07575021 ! gas homeostasis GO:0033483 11 6 0,000 0,02041962 0,07562823 ! hair follicle maturation GO:0048820 7 6 0,000 0,02041962 0,07550664 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02041962 0,07538544 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02041962 0,07526463 ! Schwann cell development GO:0014044 14 6 0,000 0,02041962 0,07514421 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02041962 0,07502417 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02041962 0,07490451 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02041962 0,07478524 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02041962 0,07466634 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02041962 0,07454782 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02041962 0,07442968 ! histone ubiquitination GO:0016574 7 6 0,000 0,02041962 0,07431191 ! regulation of meiosis GO:0040020 10 6 0,000 0,02041962 0,07419452 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02041962 0,07407749 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02041962 0,07396083 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02041962 0,07384454 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02041962 0,07372862 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02041962 0,07361306 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02041962 0,07349785 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02041962 0,07338301 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02041962 0,07326853 ! receptor internalization GO:0031623 9 6 0,000 0,02041962 0,07315441 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02041962 0,07304064 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02041962 0,07292722 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02041962 0,07281415 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02041962 0,07270144 ! protein deubiquitination GO:0016579 8 6 0,000 0,02041962 0,07258907 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02041962 0,07247705 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02041962 0,07236538 ! axonal fasciculation GO:0007413 9 6 0,000 0,02041962 0,07225405 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02041962 0,07214306 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02041962 0,07203241 ! midbrain development GO:0030901 6 6 0,000 0,02041962 0,0719221 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02041962 0,07181212 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02041962 0,07170249 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02041962 0,07159318 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02041962 0,07148422 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02041962 0,07137558 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02041962 0,07126727 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02041962 0,07115929 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02041962 0,07105163 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02041962 0,0709443 ! adult feeding behavior GO:0008343 6 6 0,000 0,02041962 0,0708373 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02041962 0,07073062 ! pigment granule transport GO:0051904 12 6 0,000 0,02041962 0,07062425 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02041962 0,07051821 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02041962 0,07041249 ! catecholamine transport GO:0051937 7 6 0,000 0,02041962 0,07030708 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02041962 0,07020199 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02041962 0,07009721 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02041962 0,06999274 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02041962 0,06988859 ! protein prenylation GO:0018342 10 6 0,000 0,02041962 0,06978474 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02041962 0,0696812 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02041962 0,06957797 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02041962 0,06947504 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02041962 0,06937242 ! regulation of caspase activity GO:0043281 97 65 1,000 0,02097811 0,07116468 ! B cell activation GO:0042113 104 65 1,000 0,02097811 0,07105988 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,02097811 0,07095538 ! protein oligomerization GO:0051259 100 65 1,000 0,02097811 0,07085118 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,02158654 0,0727992 ! regulation of immune effector process GO:0002697 101 66 1,000 0,02158654 0,07269261 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,02220228 0,07465679 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,02282527 0,07663958 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,02282527 0,07652786 ! response to drug GO:0042493 108 69 1,000 0,02345544 0,07852623 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,0237828 0,07950644 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,0237828 0,07939104 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,0237828 0,07927598 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,0237828 0,07916126 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,0237828 0,07904686 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0237828 0,0789328 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,0237828 0,07881906 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0237828 0,07870565 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,0237828 0,07859257 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,0237828 0,07847981 ! reproductive behavior GO:0019098 12 7 0,000 0,0237828 0,07836738 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,0237828 0,07825526 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,0237828 0,07814347 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,0237828 0,078032 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,0237828 0,07792084 ! oligopeptide transport GO:0006857 11 7 0,000 0,0237828 0,07781 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,0237828 0,07769947 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,0237828 0,07758926 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,0237828 0,07747936 ! RNA methylation GO:0001510 11 7 0,000 0,0237828 0,07736977 ! pericardium development GO:0060039 8 7 0,000 0,0237828 0,07726049 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,0237828 0,07715152 ! fibril organization GO:0043206 13 7 0,000 0,0237828 0,07704286 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,0237828 0,0769345 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0237828 0,07682644 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,0237828 0,07671869 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,0237828 0,07661124 ! lipoprotein transport GO:0042953 9 7 0,000 0,0237828 0,0765041 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,0237828 0,07639725 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0237828 0,0762907 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0237828 0,07618444 ! estrogen metabolic process GO:0008210 14 7 0,000 0,0237828 0,07607848 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,0237828 0,07597282 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,0237828 0,07586745 ! chemosensory behavior GO:0007635 9 7 0,000 0,0237828 0,07576237 ! microtubule bundle formation GO:0001578 8 7 0,000 0,0237828 0,07565758 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,0237828 0,07555308 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,0237828 0,07544887 ! leukocyte degranulation GO:0043299 10 7 0,000 0,0237828 0,07534494 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,0237828 0,0752413 ! reflex GO:0060004 12 7 0,000 0,0237828 0,07513795 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0237828 0,07503488 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,0237828 0,07493209 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0237828 0,07482959 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,0237828 0,07472736 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,0237828 0,07462541 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0237828 0,07452374 ! spinal cord patterning GO:0021511 7 7 0,000 0,0237828 0,07442235 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,0237828 0,07432123 ! adrenal gland development GO:0030325 17 7 0,000 0,0237828 0,07422039 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,0237828 0,07411982 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,0237828 0,07401952 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,0237828 0,0739195 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,0237828 0,07381974 ! endosome organization GO:0007032 10 7 0,000 0,0237828 0,07372025 ! thyroid hormone generation GO:0006590 11 7 0,000 0,0237828 0,07362103 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,0237828 0,07352208 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,0237828 0,07342339 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,0237828 0,07332497 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0237828 0,07322681 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,0237828 0,07312892 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0237828 0,07303128 ! galactose metabolic process GO:0006012 10 7 0,000 0,0237828 0,0729339 ! vesicle fusion GO:0006906 15 7 0,000 0,0237828 0,07283679 ! intracellular pH reduction GO:0051452 10 7 0,000 0,0237828 0,07273993 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,0237828 0,07264333 ! organ growth GO:0035265 11 7 0,000 0,0237828 0,07254699 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,0237828 0,0724509 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,0237828 0,07235506 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,0237828 0,07225948 ! retinol metabolic process GO:0042572 9 7 0,000 0,0237828 0,07216415 ! behavioral fear response GO:0001662 13 7 0,000 0,0237828 0,07206908 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,0237828 0,07197425 ! rRNA modification GO:0000154 12 7 0,000 0,0237828 0,07187967 ! protein heterooligomerization GO:0051291 10 7 0,000 0,0237828 0,07178534 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0237828 0,07169126 ! response to UV-B GO:0010224 11 7 0,000 0,0237828 0,07159742 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,0237828 0,07150383 ! intermediate filament organization GO:0045109 11 7 0,000 0,0237828 0,07141048 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,0237828 0,07131738 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,0237828 0,07122452 ! fibrinolysis GO:0042730 9 7 0,000 0,0237828 0,0711319 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,0237828 0,07103952 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,0237828 0,07094738 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,0237828 0,07085548 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,0237828 0,07076381 ! response to tropane GO:0014073 13 7 0,000 0,0237828 0,07067239 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,0237828 0,0705812 ! melanosome localization GO:0032400 10 7 0,000 0,0237828 0,07049024 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,0237828 0,07039952 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,0237828 0,07030903 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,0237828 0,07021878 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,0237828 0,07012875 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,0237828 0,07003896 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,0237828 0,0699494 ! mast cell activation GO:0045576 9 7 0,000 0,0237828 0,06986006 ! multicellular organismal aging GO:0010259 11 7 0,000 0,0237828 0,06977095 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,0237828 0,06968207 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,0237828 0,06959342 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,0237828 0,06950499 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,0237828 0,06941679 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,0237828 0,06932881 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,0237828 0,06924105 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,0237828 0,06915351 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,0237828 0,0690662 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,0237828 0,0689791 ! regulation of lipid transport GO:0032368 13 7 0,000 0,0237828 0,06889223 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,0237828 0,06880557 ! neuroblast proliferation GO:0007405 13 7 0,000 0,0237828 0,06871913 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,0237828 0,06863291 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,0237828 0,0685469 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,0237828 0,06846111 ! diuresis GO:0030146 12 7 0,000 0,0237828 0,06837554 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,0237828 0,06829017 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,0237828 0,06820502 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0237828 0,06812009 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,0237828 0,06803536 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0237828 0,06795084 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0237828 0,06786654 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0237828 0,06778244 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,0237828 0,06769855 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,0237828 0,06761487 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,0237828 0,06753139 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,0237828 0,06744812 ! lymph node development GO:0048535 9 7 0,000 0,0237828 0,06736506 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,0237828 0,0672822 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,0237828 0,06719954 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0237828 0,06711709 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,0237828 0,06703484 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,0237828 0,06695279 ! ATP catabolic process GO:0006200 10 7 0,000 0,0237828 0,06687094 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,0237828 0,06678929 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,0237828 0,06670784 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,0237828 0,06662659 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,0237828 0,06654553 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,0237828 0,06646468 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,0237828 0,06638402 ! muscle adaptation GO:0043500 12 7 0,000 0,0237828 0,06630355 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,0237828 0,06622328 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,0237828 0,0661432 ! retina homeostasis GO:0001895 9 7 0,000 0,0237828 0,06606332 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,0237828 0,06598363 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,0237828 0,06590413 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,0237828 0,06582482 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,0237828 0,06574571 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,0237828 0,06566678 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,0237828 0,06558804 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0237828 0,0655095 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,02409276 0,0662839 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,02409276 0,06620471 ! regulation of catabolic process GO:0009894 106 70 1,000 0,02409276 0,0661257 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,02473715 0,06781341 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,02473715 0,06773268 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,02473715 0,06765214 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,02538858 0,06935123 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,02538858 0,06926896 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 1,000 0,02538858 0,06918689 ! negative regulation of transport GO:0051051 116 73 1,000 0,02604698 0,0708971 ! mitochondrion organization GO:0007005 104 73 1,000 0,02604698 0,0708133 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,02604698 0,07072969 ! response to oxygen levels GO:0070482 137 74 1,000 0,0267123 0,07245081 ! protein import into nucleus GO:0006606 118 74 1,000 0,0267123 0,07236547 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,0267123 0,07228034 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,0267123 0,0721954 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02713461 0,07325072 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02713461 0,07316484 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,02713461 0,07307917 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02713461 0,0729937 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02713461 0,07290842 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02713461 0,07282335 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02713461 0,07273848 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02713461 0,0726538 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02713461 0,07256932 ! phosphate transport GO:0006817 10 8 0,000 0,02713461 0,07248503 ! N-glycan processing GO:0006491 12 8 0,000 0,02713461 0,07240094 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02713461 0,07231705 ! UTP metabolic process GO:0046051 8 8 0,000 0,02713461 0,07223335 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02713461 0,07214984 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02713461 0,07206653 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02713461 0,0719834 ! succinate metabolic process GO:0006105 14 8 0,000 0,02713461 0,07190047 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02713461 0,07181774 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02713461 0,07173519 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02713461 0,07165283 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02713461 0,07157066 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02713461 0,07148867 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02713461 0,07140688 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02713461 0,07132527 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02713461 0,07124385 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02713461 0,07116261 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02713461 0,07108156 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02713461 0,0710007 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02713461 0,07092001 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02713461 0,07083951 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02713461 0,0707592 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02713461 0,07067906 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02713461 0,07059911 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02713461 0,07051934 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02713461 0,07043974 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02713461 0,07036033 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02713461 0,07028109 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02713461 0,07020204 ! melanin metabolic process GO:0006582 12 8 0,000 0,02713461 0,07012316 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02713461 0,07004446 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02713461 0,06996593 ! macrophage activation GO:0042116 12 8 0,000 0,02713461 0,06988758 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02713461 0,06980941 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02713461 0,06973141 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02713461 0,06965358 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02713461 0,06957593 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02713461 0,06949845 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02713461 0,06942115 ! ruffle organization GO:0031529 11 8 0,000 0,02713461 0,06934401 ! osteoblast development GO:0002076 13 8 0,000 0,02713461 0,06926705 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02713461 0,06919026 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02713461 0,06911363 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02713461 0,06903718 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02713461 0,0689609 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02713461 0,06888478 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02713461 0,06880883 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02713461 0,06873305 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02713461 0,06865744 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02713461 0,06858199 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02713461 0,06850671 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02713461 0,06843159 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02713461 0,06835664 ! segment specification GO:0007379 10 8 0,000 0,02713461 0,06828185 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02713461 0,06820723 ! cellular extravasation GO:0045123 11 8 0,000 0,02713461 0,06813276 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02713461 0,06805846 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02713461 0,06798433 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02713461 0,06791035 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,02713461 0,06783653 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02713461 0,06776288 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02713461 0,06768938 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02713461 0,06761605 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02713461 0,06754287 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02713461 0,06746985 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02713461 0,06739699 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02713461 0,06732428 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02713461 0,06725174 ! icosanoid secretion GO:0032309 12 8 0,000 0,02713461 0,06717935 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02713461 0,06710711 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02713461 0,06703503 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02713461 0,0669631 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02713461 0,06689133 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02713461 0,06681971 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02713461 0,06674825 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02713461 0,06667694 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02713461 0,06660578 ! sterol catabolic process GO:0016127 9 8 0,000 0,02713461 0,06653477 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02713461 0,06646391 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02713461 0,0663932 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02713461 0,06632265 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02713461 0,06625224 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02713461 0,06618198 ! prophase GO:0051324 11 8 0,000 0,02713461 0,06611188 ! S phase GO:0051320 8 8 0,000 0,02713461 0,06604192 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02713461 0,06597211 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02713461 0,06590244 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02713461 0,06583292 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02713461 0,06576355 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02713461 0,06569433 ! hormone catabolic process GO:0042447 13 8 0,000 0,02713461 0,06562525 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02713461 0,06555631 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02713461 0,06548753 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02713461 0,06541888 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02713461 0,06535038 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02713461 0,06528202 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02713461 0,06521381 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02713461 0,06514573 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02713461 0,0650778 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02713461 0,06501001 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02713461 0,06494236 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02713461 0,06487486 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02713461 0,06480749 ! regulation of embryonic development GO:0045995 16 8 0,000 0,02713461 0,06474026 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02713461 0,06467317 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02713461 0,06460622 ! response to nutrient GO:0007584 104 75 1,000 0,02738449 0,06513373 ! regulation of ligase activity GO:0051340 114 75 1,000 0,02738449 0,06506644 ! nuclear import GO:0051170 121 75 1,000 0,02738449 0,06499929 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,02806349 0,06654229 ! protein ubiquitination GO:0016567 125 77 1,000 0,02874925 0,06809811 ! T cell activation GO:0042110 134 79 1,000 0,03014084 0,07132092 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03047512 0,07203779 ! regulation of developmental growth GO:0048638 13 9 0,000 0,03047512 0,07196382 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,03047512 0,07189002 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03047512 0,07181636 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03047512 0,07174285 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03047512 0,07166949 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03047512 0,07159629 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03047512 0,07152323 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,03047512 0,07145032 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03047512 0,07137756 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03047512 0,07130495 ! GTP metabolic process GO:0046039 9 9 0,000 0,03047512 0,07123249 ! social behavior GO:0035176 14 9 0,000 0,03047512 0,07116017 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03047512 0,071088 ! artery development GO:0060840 19 9 0,000 0,03047512 0,07101597 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03047512 0,07094409 ! regulation of glycolysis GO:0006110 15 9 0,000 0,03047512 0,07087236 ! response to pain GO:0048265 16 9 0,000 0,03047512 0,07080077 ! protein complex disassembly GO:0043241 17 9 0,000 0,03047512 0,07072933 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03047512 0,07065803 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03047512 0,07058687 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03047512 0,07051586 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03047512 0,07044499 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03047512 0,07037426 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03047512 0,07030368 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03047512 0,07023323 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03047512 0,07016293 ! protein targeting to ER GO:0045047 19 9 0,000 0,03047512 0,07009277 ! T cell selection GO:0045058 18 9 0,000 0,03047512 0,07002274 ! endoderm development GO:0007492 12 9 0,000 0,03047512 0,06995286 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03047512 0,06988312 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03047512 0,06981351 ! arginine catabolic process GO:0006527 10 9 0,000 0,03047512 0,06974405 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03047512 0,06967472 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03047512 0,06960553 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03047512 0,06953647 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03047512 0,06946756 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03047512 0,06939878 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03047512 0,06933013 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03047512 0,06926163 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03047512 0,06919325 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03047512 0,06912502 ! mannose metabolic process GO:0006013 9 9 0,000 0,03047512 0,06905691 ! receptor clustering GO:0043113 15 9 0,000 0,03047512 0,06898894 ! epithelial cell development GO:0002064 10 9 0,000 0,03047512 0,06892111 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03047512 0,0688534 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03047512 0,06878583 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03047512 0,0687184 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03047512 0,06865109 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03047512 0,06858392 ! motor axon guidance GO:0008045 14 9 0,000 0,03047512 0,06851688 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03047512 0,06844997 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03047512 0,06838319 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03047512 0,06831654 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,03047512 0,06825001 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03047512 0,06818362 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03047512 0,06811736 ! DNA ligation GO:0006266 14 9 0,000 0,03047512 0,06805123 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03047512 0,06798522 ! response to amine stimulus GO:0014075 13 9 0,000 0,03047512 0,06791935 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03047512 0,0678536 ! erythrocyte development GO:0048821 11 9 0,000 0,03047512 0,06778797 ! renal water homeostasis GO:0003091 14 9 0,000 0,03047512 0,06772248 ! postreplication repair GO:0006301 11 9 0,000 0,03047512 0,06765711 ! mRNA cleavage GO:0006379 13 9 0,000 0,03047512 0,06759187 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03047512 0,06752675 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03047512 0,06746176 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03047512 0,06739689 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03047512 0,06733215 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03047512 0,06726753 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03047512 0,06720303 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03047512 0,06713866 ! acid secretion GO:0046717 14 9 0,000 0,03047512 0,06707442 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03047512 0,06701029 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03047512 0,06694629 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03047512 0,06688241 ! purine base metabolic process GO:0006144 18 9 0,000 0,03047512 0,06681865 ! thymus development GO:0048538 15 9 0,000 0,03047512 0,06675501 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03047512 0,0666915 ! spleen development GO:0048536 15 9 0,000 0,03047512 0,0666281 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03047512 0,06656483 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03047512 0,06650167 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03047512 0,06643864 ! detection of calcium ion GO:0005513 13 9 0,000 0,03047512 0,06637572 ! blastocyst formation GO:0001825 12 9 0,000 0,03047512 0,06631293 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03047512 0,06625025 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03047512 0,06618769 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03047512 0,06612525 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03047512 0,06606293 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03047512 0,06600072 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03047512 0,06593863 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03047512 0,06587666 ! prepulse inhibition GO:0060134 14 9 0,000 0,03047512 0,0658148 ! embryonic placenta development GO:0001892 12 9 0,000 0,03047512 0,06575306 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03047512 0,06569144 ! insulin secretion GO:0030073 17 9 0,000 0,03047512 0,06562993 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03047512 0,06556854 ! response to nicotine GO:0035094 16 9 0,000 0,03047512 0,06550726 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03047512 0,06544609 ! nucleus localization GO:0051647 15 9 0,000 0,03047512 0,06538504 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03047512 0,06532411 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,03084657 0,06605876 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,03084657 0,06599731 ! mRNA transport GO:0051028 121 81 1,000 0,03155885 0,0674585 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,03155885 0,06739587 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,03155885 0,06733335 GO:0002696|positive regulation of leukocyte activation, ! regulation of defense response GO:0031347 117 84 1,000 0,03373448 0,07190852 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03380434 0,07199072 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03380434 0,07192412 ! neuron fate specification GO:0048665 11 10 0,000 0,03380434 0,07185765 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03380434 0,0717913 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03380434 0,07172507 ! thyroid gland development GO:0030878 19 10 0,000 0,03380434 0,07165896 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03380434 0,07159298 ! synapsis GO:0007129 13 10 0,000 0,03380434 0,07152712 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03380434 0,07146137 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03380434 0,07139575 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03380434 0,07133025 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03380434 0,07126487 ! sulfate transport GO:0008272 12 10 0,000 0,03380434 0,07119961 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03380434 0,07113447 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,03380434 0,07106945 ! androgen metabolic process GO:0008209 13 10 0,000 0,03380434 0,07100454 ! phospholipid efflux GO:0033700 16 10 0,000 0,03380434 0,07093976 ! hippocampus development GO:0021766 19 10 0,000 0,03380434 0,07087509 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,03380434 0,07081054 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03380434 0,07074611 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03380434 0,0706818 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03380434 0,0706176 ! pathogenesis GO:0009405 13 10 0,000 0,03380434 0,07055352 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03380434 0,07048955 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03380434 0,0704257 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03380434 0,07036197 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,03380434 0,07029835 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03380434 0,07023485 ! melanocyte differentiation GO:0030318 15 10 0,000 0,03380434 0,07017146 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03380434 0,07010818 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,03380434 0,07004502 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03380434 0,06998198 ! B cell proliferation GO:0042100 14 10 0,000 0,03380434 0,06991904 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03380434 0,06985622 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,03380434 0,06979351 ! forebrain cell migration GO:0021885 17 10 0,000 0,03380434 0,06973092 ! lipid digestion GO:0044241 15 10 0,000 0,03380434 0,06966844 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03380434 0,06960607 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03380434 0,06954381 ! UV protection GO:0009650 14 10 0,000 0,03380434 0,06948166 ! entry into host cell GO:0030260 20 10 0,000 0,03380434 0,06941962 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03380434 0,06935769 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03380434 0,06929588 ! negative regulation of ossification GO:0030279 19 10 0,000 0,03380434 0,06923417 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03380434 0,06917258 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03380434 0,06911109 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03380434 0,06904971 ! regulation of organ growth GO:0046620 11 10 0,000 0,03380434 0,06898844 ! response to dsRNA GO:0043331 18 10 0,000 0,03380434 0,06892728 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03380434 0,06886623 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03380434 0,06880529 ! embryonic axis specification GO:0000578 12 10 0,000 0,03380434 0,06874445 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03380434 0,06868372 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03380434 0,0686231 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03380434 0,06856259 ! cranial nerve development GO:0021545 12 10 0,000 0,03380434 0,06850218 ! fucose catabolic process GO:0019317 16 10 0,000 0,03380434 0,06844188 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,03380434 0,06838168 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03380434 0,0683216 ! protein sumoylation GO:0016925 12 10 0,000 0,03380434 0,06826161 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03380434 0,06820173 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03380434 0,06814196 ! zymogen activation GO:0031638 14 10 0,000 0,03380434 0,06808229 ! salivary gland development GO:0007431 22 10 0,000 0,03380434 0,06802273 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03380434 0,06796327 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03380434 0,06790391 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03380434 0,06784466 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,03380434 0,06778551 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03380434 0,06772646 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03380434 0,06766752 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03380434 0,06760867 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03380434 0,06754994 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,03380434 0,0674913 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03380434 0,06743276 ! detection of bacterium GO:0016045 10 10 0,000 0,03380434 0,06737433 ! embryonic gut development GO:0048566 11 10 0,000 0,03380434 0,067316 ! activation of innate immune response GO:0002218 10 10 0,000 0,03380434 0,06725776 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03380434 0,06719963 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03380434 0,0671416 ! developmental induction GO:0031128 13 10 0,000 0,03380434 0,06708367 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,03380434 0,06702584 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,03380434 0,06696811 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03380434 0,06691048 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03380434 0,06685295 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,03447245 0,06811566 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,03447245 0,06805719 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,03447245 0,06799883 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,03596723 0,07088656 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,03672393 0,07231596 ! establishment of RNA localization GO:0051236 128 88 1,000 0,03672393 0,0722541 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! rRNA transcription GO:0009303 17 11 0,000 0,03712232 0,07297549 ! respiratory burst GO:0045730 14 11 0,000 0,03712232 0,07291318 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03712232 0,07285096 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03712232 0,07278886 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03712232 0,07272686 ! virus-host interaction GO:0019048 17 11 0,000 0,03712232 0,07266496 ! filopodium assembly GO:0046847 19 11 0,000 0,03712232 0,07260317 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03712232 0,07254149 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03712232 0,07247991 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03712232 0,07241843 ! mating GO:0007618 14 11 0,000 0,03712232 0,07235706 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,03712232 0,07229579 ! T cell proliferation GO:0042098 20 11 0,000 0,03712232 0,07223463 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03712232 0,07217357 ! bone resorption GO:0045453 16 11 0,000 0,03712232 0,07211261 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03712232 0,07205175 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,03712232 0,071991 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03712232 0,07193035 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03712232 0,07186981 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03712232 0,07180936 ! syncytium formation GO:0006949 15 11 0,000 0,03712232 0,07174902 ! plasma membrane organization GO:0007009 18 11 0,000 0,03712232 0,07168877 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03712232 0,07162863 ! focal adhesion formation GO:0048041 24 11 0,000 0,03712232 0,07156859 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03712232 0,07150865 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03712232 0,07144881 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03712232 0,07138907 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03712232 0,07132943 ! adult heart development GO:0007512 11 11 0,000 0,03712232 0,07126989 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,03712232 0,07121045 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,03712232 0,07115111 ! temperature homeostasis GO:0001659 16 11 0,000 0,03712232 0,07109186 ! L-glutamate transport GO:0015813 16 11 0,000 0,03712232 0,07103272 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03712232 0,07097367 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03712232 0,07091472 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03712232 0,07085587 ! stem cell development GO:0048864 29 11 0,000 0,03712232 0,07079712 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,03712232 0,07073847 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03712232 0,07067991 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03712232 0,07062145 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03712232 0,07056308 ! vasoconstriction GO:0042310 15 11 0,000 0,03712232 0,07050481 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03712232 0,07044664 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03712232 0,07038856 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03712232 0,07033058 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03712232 0,0702727 ! ribosome assembly GO:0042255 13 11 0,000 0,03712232 0,07021491 ! histone deacetylation GO:0016575 13 11 0,000 0,03712232 0,07015721 ! chromatin silencing GO:0006342 19 11 0,000 0,03712232 0,07009961 ! nucleosome positioning GO:0016584 13 11 0,000 0,03712232 0,07004211 ! T cell homeostasis GO:0043029 20 11 0,000 0,03712232 0,0699847 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03712232 0,06992738 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03712232 0,06987015 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03712232 0,06981302 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03712232 0,06975599 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03712232 0,06969904 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03712232 0,06964219 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03712232 0,06958543 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03712232 0,06952877 ! male genitalia development GO:0030539 13 11 0,000 0,03712232 0,0694722 ! cholesterol efflux GO:0033344 19 11 0,000 0,03712232 0,06941571 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03712232 0,06935932 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03712232 0,06930303 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03712232 0,06924682 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,03712232 0,0691907 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,03712232 0,06913468 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03712232 0,06907874 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,03712232 0,0690229 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,03712232 0,06896715 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03712232 0,06891148 ! lysogeny GO:0030069 18 11 0,000 0,03712232 0,06885591 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,03712232 0,06880043 ! acrosome reaction GO:0007340 13 11 0,000 0,03712232 0,06874503 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03712232 0,06868973 ! leukocyte differentiation GO:0002521 143 90 1,000 0,03825573 0,07073006 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,03825573 0,07067324 ! RNA localization GO:0006403 135 91 1,000 0,03903073 0,07204709 ! DNA recombination GO:0006310 146 92 1,000 0,03981172 0,0734298 ! lactation GO:0007595 20 12 0,000 0,04042909 0,07450874 ! reproductive cellular process GO:0048610 14 12 0,000 0,04042909 0,07444909 ! tRNA modification GO:0006400 14 12 0,000 0,04042909 0,07438953 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04042909 0,07433006 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04042909 0,0742707 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,04042909 0,07421142 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04042909 0,07415224 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04042909 0,07409316 ! non-recombinational repair GO:0000726 19 12 0,000 0,04042909 0,07403416 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04042909 0,07397527 ! peroxisomal transport GO:0043574 21 12 0,000 0,04042909 0,07391646 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04042909 0,07385775 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04042909 0,07379914 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04042909 0,07374061 ! heart looping GO:0001947 15 12 0,000 0,04042909 0,07368218 ! palate development GO:0060021 15 12 0,000 0,04042909 0,07362384 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04042909 0,07356559 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04042909 0,07350744 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04042909 0,07344938 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04042909 0,07339141 ! arginine metabolic process GO:0006525 13 12 0,000 0,04042909 0,07333353 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04042909 0,07327574 ! methionine metabolic process GO:0006555 13 12 0,000 0,04042909 0,07321804 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04042909 0,07316043 ! Golgi organization GO:0007030 18 12 0,000 0,04042909 0,07310292 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,04042909 0,07304549 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04042909 0,07298816 ! monoamine transport GO:0015844 13 12 0,000 0,04042909 0,07293091 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04042909 0,07287375 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,04042909 0,07281669 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04042909 0,07275971 ! L-amino acid transport GO:0015807 20 12 0,000 0,04042909 0,07270282 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04042909 0,07264602 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04042909 0,07258931 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04042909 0,07253269 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04042909 0,07247616 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04042909 0,07241971 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04042909 0,07236335 ! cerebellum development GO:0021549 13 12 0,000 0,04042909 0,07230708 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04042909 0,0722509 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04042909 0,07219481 ! histone acetylation GO:0016573 23 12 0,000 0,04042909 0,0721388 ! histone methylation GO:0016571 15 12 0,000 0,04042909 0,07208288 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04042909 0,07202704 ! gland morphogenesis GO:0022612 23 12 0,000 0,04042909 0,07197129 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04042909 0,07191563 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,04042909 0,07186005 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04042909 0,07180456 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04042909 0,07174916 ! intestinal absorption GO:0050892 19 12 0,000 0,04042909 0,07169384 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04042909 0,07163861 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04042909 0,07158346 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04042909 0,07152839 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04042909 0,07147341 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04042909 0,07141852 ! microspike assembly GO:0030035 23 12 0,000 0,04042909 0,07136371 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04042909 0,07130898 ! response to cold GO:0009409 14 12 0,000 0,04042909 0,07125434 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,04059866 0,07149841 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,04059866 0,07144371 ! response to oxidative stress GO:0006979 141 94 1,000 0,04139151 0,07278323 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,0429947 0,07554455 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,0429947 0,07548688 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,0429947 0,0754293 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,0437247 0,07665153 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,0437247 0,07659315 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,0437247 0,07653486 ! cGMP metabolic process GO:0046068 16 13 0,000 0,0437247 0,07647666 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,0437247 0,07641855 ! water transport GO:0006833 17 13 0,000 0,0437247 0,07636052 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,0437247 0,07630258 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,0437247 0,07624474 ! lipid localization GO:0010876 24 13 0,000 0,0437247 0,07618697 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,0437247 0,0761293 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,0437247 0,07607171 ! organelle fusion GO:0048284 28 13 0,000 0,0437247 0,07601422 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,0437247 0,0759568 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,0437247 0,07589948 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,0437247 0,07584224 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,0437247 0,07578508 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,0437247 0,07572802 ! response to hexose stimulus GO:0009746 19 13 0,000 0,0437247 0,07567104 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,0437247 0,07561414 ! glutamate metabolic process GO:0006536 18 13 0,000 0,0437247 0,07555733 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,0437247 0,07550061 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,0437247 0,07544397 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,0437247 0,07538741 ! NAD metabolic process GO:0019674 21 13 0,000 0,0437247 0,07533094 ! exocrine system development GO:0035272 27 13 0,000 0,0437247 0,07527456 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,0437247 0,07521825 ! bone mineralization GO:0030282 15 13 0,000 0,0437247 0,07516204 ! regulation of exocytosis GO:0017157 17 13 0,000 0,0437247 0,0751059 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,0437247 0,07504986 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,0437247 0,07499389 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,0437247 0,07493801 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,0437247 0,07488221 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,0437247 0,07482649 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,0437247 0,07477086 ! genitalia development GO:0048806 15 13 0,000 0,0437247 0,07471531 ! cellular pigmentation GO:0033059 24 13 0,000 0,0437247 0,07465984 ! tissue regeneration GO:0042246 21 13 0,000 0,0437247 0,07460446 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,0437247 0,07454915 ! cofactor transport GO:0051181 19 13 0,000 0,0437247 0,07449393 ! NADP metabolic process GO:0006739 18 13 0,000 0,0437247 0,07443879 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,0437247 0,07438373 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,0437247 0,07432876 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0437247 0,07427386 ! gas transport GO:0015669 18 13 0,000 0,0437247 0,07421905 ! heme biosynthetic process GO:0006783 20 13 0,000 0,0437247 0,07416431 ! regulation of axon extension GO:0030516 23 13 0,000 0,0437247 0,07410966 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,0437247 0,07405509 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,0437247 0,07400059 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,0437247 0,07394618 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,0437247 0,07389185 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,0437247 0,0738376 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,0437247 0,07378342 ! protein import GO:0017038 156 99 1,000 0,04544254 0,07662599 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,04626978 0,07796374 ! protein localization in organelle GO:0033365 161 100 1,000 0,04626978 0,07790666 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,04700917 0,07909371 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,04700917 0,07903589 ! superoxide anion generation GO:0042554 18 14 0,000 0,04700917 0,07897816 ! neuron maturation GO:0042551 21 14 0,000 0,04700917 0,07892051 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,04700917 0,07886295 ! myotube differentiation GO:0014902 21 14 0,000 0,04700917 0,07880547 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,04700917 0,07874807 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,04700917 0,07869076 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,04700917 0,07863353 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,04700917 0,07857638 ! gene silencing by RNA GO:0031047 20 14 0,000 0,04700917 0,07851932 ! response to cAMP GO:0051591 19 14 0,000 0,04700917 0,07846234 ! limbic system development GO:0021761 25 14 0,000 0,04700917 0,07840544 ! startle response GO:0001964 21 14 0,000 0,04700917 0,07834862 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,04700917 0,07829189 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,04700917 0,07823524 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,04700917 0,07817867 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,04700917 0,07812218 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,04700917 0,07806578 ! glycine metabolic process GO:0006544 22 14 0,000 0,04700917 0,07800945 ! pituitary gland development GO:0021983 23 14 0,000 0,04700917 0,07795321 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,04700917 0,07789705 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,04700917 0,07784097 ! regulation of heart rate GO:0002027 23 14 0,000 0,04700917 0,07778497 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,04700917 0,07772905 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,04700917 0,07767321 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,04700917 0,07761745 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,04700917 0,07756177 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,04700917 0,07750617 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,04700917 0,07745065 ! axon cargo transport GO:0008088 27 14 0,000 0,04700917 0,07739521 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,04700917 0,07733984 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,04700917 0,07728456 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,04700917 0,07722936 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,04700917 0,07717423 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,04700917 0,07711919 ! mRNA splice site selection GO:0006376 26 14 0,000 0,04700917 0,07706422 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,04700917 0,07700933 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,04700917 0,07695452 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,04700917 0,07689979 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,04700917 0,07684513 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,04700917 0,07679056 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,04700917 0,07673606 ! muscle maintenance GO:0046716 19 14 0,000 0,04700917 0,07668163 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,04700917 0,07662729 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,04700917 0,07657302 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,04700917 0,07651883 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,04700917 0,07646471 ! cell killing GO:0001906 20 14 0,000 0,04700917 0,07641067 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,04700917 0,07635671 ! cilium assembly GO:0042384 20 14 0,000 0,04700917 0,07630282 ! peptide hormone secretion GO:0030072 23 14 0,000 0,04700917 0,07624901 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,05028256 0,08150097 ! positive regulation of cell size GO:0045793 20 15 0,000 0,05028256 0,08144358 ! metencephalon development GO:0022037 19 15 0,000 0,05028256 0,08138626 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,05028256 0,08132903 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,05028256 0,08127188 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,05028256 0,08121481 ! skin development GO:0043588 25 15 0,000 0,05028256 0,08115781 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,05028256 0,0811009 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,05028256 0,08104407 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,05028256 0,08098731 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,05028256 0,08093064 ! bile acid metabolic process GO:0008206 22 15 0,000 0,05028256 0,08087404 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,05028256 0,08081753 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,05028256 0,08076109 ! adult walking behavior GO:0007628 25 15 0,000 0,05028256 0,08070473 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,05028256 0,08064845 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,05028256 0,08059225 ! myoblast differentiation GO:0045445 27 15 0,000 0,05028256 0,08053613 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,05028256 0,08048009 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,05028256 0,08042412 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,05028256 0,08036823 ! cerebral cortex development GO:0021987 29 15 0,000 0,05028256 0,08031242 ! response to osmotic stress GO:0006970 22 15 0,000 0,05028256 0,08025668 ! vesicle coating GO:0006901 25 15 0,000 0,05028256 0,08020103 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,05028256 0,08014545 ! DNA integration GO:0015074 22 15 0,000 0,05028256 0,08008995 ! peptide secretion GO:0002790 27 15 0,000 0,05028256 0,08003452 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,05028256 0,07997917 ! regulation of vasodilation GO:0042312 24 15 0,000 0,05028256 0,0799239 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,05028256 0,0798687 ! neuron recognition GO:0008038 22 15 0,000 0,05028256 0,07981358 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,05028256 0,07975854 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,05028256 0,07970357 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,05028256 0,07964868 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,05028256 0,07959386 ! biomineral formation GO:0031214 18 15 0,000 0,05028256 0,07953912 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,05028256 0,07948446 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,05028256 0,07942986 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,05028256 0,07937535 ! dopamine metabolic process GO:0042417 30 15 0,000 0,05028256 0,07932091 ! organic cation transport GO:0015695 19 15 0,000 0,05028256 0,07926654 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,05028256 0,07921225 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,05028256 0,07915803 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,05028256 0,07910389 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,05028256 0,07904982 ! peptide hormone processing GO:0016486 19 15 0,000 0,05028256 0,07899582 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,05028256 0,0789419 ! protein secretion GO:0009306 27 16 0,000 0,05354488 0,0840063 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,05354488 0,08394903 ! hormone secretion GO:0046879 25 16 0,000 0,05354488 0,08389185 ! bone remodeling GO:0046849 24 16 0,000 0,05354488 0,08383474 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,05354488 0,08377771 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,05354488 0,08372076 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05354488 0,08366388 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,05354488 0,08360708 ! glial cell development GO:0021782 24 16 0,000 0,05354488 0,08355036 ! patterning of blood vessels GO:0001569 24 16 0,000 0,05354488 0,08349372 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,05354488 0,08343715 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,05354488 0,08338066 ! protein polyubiquitination GO:0000209 26 16 0,000 0,05354488 0,08332424 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,05354488 0,08326791 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,05354488 0,08321164 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,05354488 0,08315546 ! fructose metabolic process GO:0006000 20 16 0,000 0,05354488 0,08309935 ! regulation of protein binding GO:0043393 27 16 0,000 0,05354488 0,08304331 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,05354488 0,08298735 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,05354488 0,08293147 ! protein export from nucleus GO:0006611 24 16 0,000 0,05354488 0,08287566 ! negative regulation of immune response GO:0050777 28 16 0,000 0,05354488 0,08281993 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,05354488 0,08276427 ! DNA replication initiation GO:0006270 25 16 0,000 0,05354488 0,08270869 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,05354488 0,08265318 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,05354488 0,08259774 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,05354488 0,08254238 ! diencephalon development GO:0021536 25 16 0,000 0,05354488 0,08248709 ! neural crest cell migration GO:0001755 24 16 0,000 0,05354488 0,08243188 ! G1 phase GO:0051318 27 16 0,000 0,05354488 0,08237674 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,05354488 0,08232168 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,05354488 0,08226669 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,05354488 0,08221177 ! steroid catabolic process GO:0006706 22 16 0,000 0,05354488 0,08215693 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,05354488 0,08210215 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,05354488 0,08204746 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,05354488 0,08199283 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,05354488 0,08193828 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,05354488 0,0818838 ! sperm-egg recognition GO:0035036 16 16 0,000 0,05354488 0,08182939 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,05354488 0,08177505 ! nerve development GO:0021675 18 16 0,000 0,05354488 0,08172079 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,05354488 0,0816666 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,05354488 0,08161248 ! negative regulation of translation GO:0017148 22 16 0,000 0,05354488 0,08155843 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,05679619 0,0864535 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,05679619 0,08639632 ! negative regulation of defense response GO:0031348 19 17 0,000 0,05679619 0,08633922 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,05679619 0,08628219 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,05679619 0,08622524 ! glycerol metabolic process GO:0006071 20 17 0,000 0,05679619 0,08616836 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,05679619 0,08611156 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,05679619 0,08605483 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,05679619 0,08599818 ! signal complex assembly GO:0007172 29 17 0,000 0,05679619 0,0859416 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,05679619 0,0858851 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,05679619 0,08582867 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,05679619 0,08577231 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,05679619 0,08571603 ! memory GO:0007613 25 17 0,000 0,05679619 0,08565983 ! keratinization GO:0031424 17 17 0,000 0,05679619 0,08560369 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,05679619 0,08554763 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,05679619 0,08549165 ! retinoid metabolic process GO:0001523 22 17 0,000 0,05679619 0,08543573 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,05679619 0,08537989 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,05679619 0,08532413 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,05679619 0,08526843 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,05679619 0,08521281 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,05679619 0,08515726 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,05679619 0,08510178 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,05679619 0,08504638 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,05679619 0,08499104 ! membrane budding GO:0006900 29 17 0,000 0,05679619 0,08493578 ! heme metabolic process GO:0042168 27 17 0,000 0,05679619 0,08488059 ! actin filament bundle formation GO:0051017 26 17 0,000 0,05679619 0,08482548 ! neuromuscular junction development GO:0007528 23 17 0,000 0,05679619 0,08477043 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,05679619 0,08471546 ! body fluid secretion GO:0007589 27 17 0,000 0,05679619 0,08466055 ! stem cell differentiation GO:0048863 36 17 0,000 0,05679619 0,08460572 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,05679619 0,08455096 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,05679619 0,08449627 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,05679619 0,08444165 ! sensory perception of pain GO:0019233 23 17 0,000 0,05679619 0,0843871 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,05679619 0,08433262 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,05679619 0,08427822 ! synaptogenesis GO:0007416 24 17 0,000 0,05679619 0,08422388 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,05679619 0,08416961 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,05679619 0,08411541 ! cell-cell junction organization GO:0045216 25 17 0,000 0,05679619 0,08406128 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,05679619 0,08400723 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,05679619 0,08395324 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,05679619 0,08389932 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,05679619 0,08384547 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,05679619 0,08379168 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,06003651 0,08851537 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,06003651 0,08845867 ! positive regulation of translation GO:0045727 28 18 0,000 0,06003651 0,08840203 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,06003651 0,08834547 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,06003651 0,08828899 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,06003651 0,08823257 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,06003651 0,08817623 ! cAMP metabolic process GO:0046058 33 18 0,000 0,06003651 0,08811996 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,06003651 0,08806376 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,06003651 0,08800763 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,06003651 0,08795158 ! axis specification GO:0009798 26 18 0,000 0,06003651 0,08789559 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,06003651 0,08783968 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,06003651 0,08778384 ! pancreas development GO:0031016 26 18 0,000 0,06003651 0,08772807 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,06003651 0,08767237 ! glutamine metabolic process GO:0006541 23 18 0,000 0,06003651 0,08761674 ! response to retinoic acid GO:0032526 25 18 0,000 0,06003651 0,08756118 ! pigmentation during development GO:0048066 31 18 0,000 0,06003651 0,08750569 ! central nervous system neuron development GO:0021954 30 18 0,000 0,06003651 0,08745027 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,06003651 0,08739492 ! fucose metabolic process GO:0006004 26 18 0,000 0,06003651 0,08733964 ! response to fungus GO:0009620 19 18 0,000 0,06003651 0,08728444 ! peptide cross-linking GO:0018149 31 18 0,000 0,06003651 0,0872293 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,06003651 0,08717423 ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,06003651 0,08711923 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,06003651 0,0870643 ! visual learning GO:0008542 35 18 0,000 0,06003651 0,08700944 ! somitogenesis GO:0001756 24 18 0,000 0,06003651 0,08695465 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,06003651 0,08689992 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,06003651 0,08684527 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,06003651 0,08679068 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,06003651 0,08673617 ! vitamin transport GO:0051180 24 18 0,000 0,06003651 0,08668172 ! hormone transport GO:0009914 27 18 0,000 0,06003651 0,08662734 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,06003651 0,08657303 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,06003651 0,08651878 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,06003651 0,08646461 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,06003651 0,0864105 ! cell-cell recognition GO:0009988 20 18 0,000 0,06003651 0,08635646 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,06003651 0,08630249 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,06003651 0,08624858 ! regulation of glucose import GO:0046324 21 18 0,000 0,06003651 0,08619474 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,06003651 0,08614097 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,06003651 0,08608727 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,06003651 0,08603363 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,06326589 0,09060494 ! positive regulation of ossification GO:0045778 30 19 0,000 0,06326589 0,09054856 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,06326589 0,09049225 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,06326589 0,09043601 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,06326589 0,09037984 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,06326589 0,09032374 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,06326589 0,0902677 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,06326589 0,09021174 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,06326589 0,09015585 ! regeneration GO:0031099 32 19 0,000 0,06326589 0,09010002 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,06326589 0,09004427 ! response to alkaloid GO:0043279 32 19 0,000 0,06326589 0,08998858 ! sensory perception of taste GO:0050909 23 19 0,000 0,06326589 0,08993297 ! smooth muscle contraction GO:0006939 36 19 0,000 0,06326589 0,08987742 ! peroxisome organization GO:0007031 29 19 0,000 0,06326589 0,08982194 ! digestive system process GO:0022600 30 19 0,000 0,06326589 0,08976653 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,06326589 0,08971118 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,06326589 0,08965591 ! response to vitamin A GO:0033189 26 19 0,000 0,06326589 0,0896007 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,06326589 0,08954556 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,06326589 0,08949049 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,06326589 0,08943549 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,06326589 0,08938055 ! sex determination GO:0007530 29 19 0,000 0,06326589 0,08932568 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,06326589 0,08927088 ! plasma membrane fusion GO:0045026 23 19 0,000 0,06326589 0,08921615 ! cytolysis GO:0019835 20 19 0,000 0,06326589 0,08916148 ! renal system process GO:0003014 35 19 0,000 0,06326589 0,08910688 ! vasodilation GO:0042311 33 19 0,000 0,06326589 0,08905235 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,06326589 0,08899788 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,06326589 0,08894348 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,06326589 0,08888915 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,06326589 0,08883488 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,06326589 0,08878068 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,06326589 0,08872655 ! sarcomere organization GO:0045214 23 19 0,000 0,06326589 0,08867248 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,06326589 0,08861848 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,06326589 0,08856454 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,06326589 0,08851067 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,06326589 0,08845686 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,06326589 0,08840312 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,06326589 0,08834945 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,06326589 0,08829584 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,06326589 0,08824229 ! protein stabilization GO:0050821 26 19 0,000 0,06326589 0,08818881 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,06648435 0,09261902 ! iron ion transport GO:0006826 37 20 0,000 0,06648435 0,09256296 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,06648435 0,09250696 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,06648435 0,09245103 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,06648435 0,09239517 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,06648435 0,09233938 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,06648435 0,09228365 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,06648435 0,09222799 ! spinal cord development GO:0021510 31 20 0,000 0,06648435 0,0921724 ! response to ethanol GO:0045471 37 20 0,000 0,06648435 0,09211687 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,06648435 0,09206141 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,06648435 0,09200602 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,06648435 0,0919507 ! chromosome condensation GO:0030261 31 20 0,000 0,06648435 0,09189544 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,06648435 0,09184025 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,06648435 0,09178512 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,06648435 0,09173006 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,06648435 0,09167506 ! pallium development GO:0021543 38 20 0,000 0,06648435 0,09162014 ! DNA modification GO:0006304 28 20 0,000 0,06648435 0,09156527 ! collagen fibril organization GO:0030199 45 20 0,000 0,06648435 0,09151048 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,06648435 0,09145575 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,06648435 0,09140108 ! collagen catabolic process GO:0030574 25 20 0,000 0,06648435 0,09134648 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,06648435 0,09129195 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,06648435 0,09123748 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,06648435 0,09118307 ! alditol metabolic process GO:0019400 24 20 0,000 0,06648435 0,09112873 ! actin filament-based movement GO:0030048 34 20 0,000 0,06648435 0,09107445 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,06969194 0,09541159 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,06969194 0,09535483 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,06969194 0,09529814 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,06969194 0,09524151 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,06969194 0,09518496 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,06969194 0,09512847 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,06969194 0,09507204 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,06969194 0,09501569 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,06969194 0,0949594 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,06969194 0,09490318 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,06969194 0,09484702 ! protein amino acid acylation GO:0043543 37 21 0,000 0,06969194 0,09479093 ! vesicle docking GO:0048278 27 21 0,000 0,06969194 0,09473491 ! phototransduction GO:0007602 25 21 0,000 0,06969194 0,09467895 ! dendrite development GO:0016358 35 21 0,000 0,06969194 0,09462306 ! visual behavior GO:0007632 39 21 0,000 0,06969194 0,09456724 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,06969194 0,09451148 ! ovarian follicle development GO:0001541 30 21 0,000 0,06969194 0,09445578 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,06969194 0,09440016 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,06969194 0,09434459 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,06969194 0,0942891 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,06969194 0,09423367 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,06969194 0,0941783 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,06969194 0,094123 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,06969194 0,09406776 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,06969194 0,09401259 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,06969194 0,09395748 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,06969194 0,09390244 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,06969194 0,09384746 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,06969194 0,09379255 ! fatty acid transport GO:0015908 30 21 0,000 0,06969194 0,0937377 ! immunoglobulin production GO:0002377 33 21 0,000 0,06969194 0,09368291 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,06969194 0,09362819 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,06969194 0,09357354 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,06969194 0,09351894 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,06969194 0,09346441 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,06969194 0,09340994 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,06969194 0,09335554 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,06969194 0,0933012 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,06969194 0,09324693 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,06969194 0,09319271 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,06969194 0,09313856 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,06969194 0,09308447 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,06969194 0,09303045 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,06969194 0,09297649 GO:0006099|tricarboxylic acid cycle, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,07288869 0,09718492 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,07288869 0,09712862 ! viral genome replication GO:0019079 29 22 0,000 0,07288869 0,09707238 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,07288869 0,0970162 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,07288869 0,09696009 ! leukocyte adhesion GO:0007159 38 22 0,000 0,07288869 0,09690404 ! molting cycle process GO:0022404 40 22 0,000 0,07288869 0,09684806 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,07288869 0,09679214 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,07288869 0,09673629 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,07288869 0,0966805 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,07288869 0,09662478 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,07288869 0,09656912 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,07288869 0,09651353 ! lysosome organization GO:0007040 37 22 0,000 0,07288869 0,09645799 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,07288869 0,09640253 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,07288869 0,09634712 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,07288869 0,09629178 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,07288869 0,09623651 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,07288869 0,09618129 ! membrane depolarization GO:0051899 35 22 0,000 0,07288869 0,09612614 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,07288869 0,09607106 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,07288869 0,09601603 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,07288869 0,09596107 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,07288869 0,09590618 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,07288869 0,09585134 ! neural tube closure GO:0001843 33 22 0,000 0,07288869 0,09579657 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,07288869 0,09574186 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,07607464 0,09986968 ! neuron fate commitment GO:0048663 32 23 0,000 0,07607464 0,09981271 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,07607464 0,0997558 ! myelination GO:0042552 35 23 0,000 0,07607464 0,09969896 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,07607464 0,09964219 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,07607464 0,09958547 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,07607464 0,09952883 ! vesicle targeting GO:0006903 32 23 0,000 0,07607464 0,09947224 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,07607464 0,09941573 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,07607464 0,09935927 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,07607464 0,09930288 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,07607464 0,09924656 ! interaction with host GO:0051701 37 23 0,000 0,07607464 0,09919029 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,07607464 0,0991341 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,07607464 0,09907796 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,07607464 0,09902189 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,07607464 0,09896588 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,07607464 0,09890994 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,07607464 0,09885406 ! cell fate determination GO:0001709 45 23 0,000 0,07607464 0,09879824 ! pentose metabolic process GO:0019321 31 23 0,000 0,07607464 0,09874248 ! spermatid development GO:0007286 33 23 0,000 0,07607464 0,09868679 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,07607464 0,09863116 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,07607464 0,09857559 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,07607464 0,09852009 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,07607464 0,09846465 ! telomere organization GO:0032200 32 23 0,000 0,07607464 0,09840927 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,07607464 0,09835395 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,07607464 0,0982987 ! regulation of amine transport GO:0051952 38 23 0,000 0,07607464 0,0982435 ! liver development GO:0001889 40 23 0,000 0,07607464 0,09818837 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,07924983 0,10222916 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,07924983 0,10217186 ! initiation of viral infection GO:0019059 42 24 0,000 0,07924983 0,10211462 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,07924983 0,10205745 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,07924983 0,10200034 ! superoxide metabolic process GO:0006801 32 24 0,000 0,07924983 0,10194329 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,07924983 0,10188631 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,07924983 0,10182939 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,07924983 0,10177253 ! sperm motility GO:0030317 27 24 0,000 0,07924983 0,10171574 ! vacuole organization GO:0007033 39 24 0,000 0,07924983 0,10165901 ! receptor metabolic process GO:0043112 37 24 0,000 0,07924983 0,10160234 ! neural crest cell development GO:0014032 39 24 0,000 0,07924983 0,10154574 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,07924983 0,1014892 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,07924983 0,10143272 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,07924983 0,10137631 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,07924983 0,10131996 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,07924983 0,10126367 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,07924983 0,10120744 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,08241428 0,10519026 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,08241428 0,10513191 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,08241428 0,10507364 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,08241428 0,10501542 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,08241428 0,10495728 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,08241428 0,10489919 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,08241428 0,10484117 ! peptide transport GO:0015833 43 25 0,000 0,08241428 0,10478322 ! male gonad development GO:0008584 33 25 0,000 0,08241428 0,10472533 ! iron ion homeostasis GO:0055072 39 25 0,000 0,08241428 0,1046675 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,08241428 0,10460974 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,08241428 0,10455204 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,08241428 0,1044944 ! phospholipid transport GO:0015914 35 25 0,000 0,08241428 0,10443683 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,08241428 0,10437932 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,08241428 0,10432187 ! detection of light stimulus GO:0009583 30 25 0,000 0,08241428 0,10426449 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,08241428 0,10420717 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,08241428 0,10414991 ! leukocyte proliferation GO:0070661 39 25 0,000 0,08241428 0,10409272 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,08241428 0,10403559 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,08556804 0,10795748 ! translational initiation GO:0006413 43 26 0,000 0,08556804 0,10789829 ! circadian rhythm GO:0007623 42 26 0,000 0,08556804 0,10783917 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,08556804 0,10778011 ! post-embryonic development GO:0009791 42 26 0,000 0,08556804 0,10772112 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,08556804 0,10766219 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,08556804 0,10760333 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,08556804 0,10754453 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,08556804 0,10748579 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,08556804 0,10742712 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,08556804 0,10736851 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,08556804 0,10730997 ! regulation of coagulation GO:0050818 39 26 0,000 0,08556804 0,10725149 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,08871113 0,11113051 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,08871113 0,11107001 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,08871113 0,11100958 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,08871113 0,11094922 ! membrane docking GO:0022406 39 27 0,000 0,08871113 0,11088892 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,08871113 0,11082868 ! catechol metabolic process GO:0009712 43 27 0,000 0,08871113 0,11076852 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,08871113 0,11070841 ! acute-phase response GO:0006953 42 27 0,000 0,08871113 0,11064838 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,08871113 0,11058841 ! myofibril assembly GO:0030239 36 27 0,000 0,08871113 0,1105285 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,08871113 0,11046866 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,08871113 0,11040888 ! natural killer cell activation GO:0030101 35 27 0,000 0,08871113 0,11034917 ! lipid oxidation GO:0034440 38 27 0,000 0,08871113 0,11028952 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,08871113 0,11022993 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,08871113 0,11017041 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,08871113 0,11011096 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,08871113 0,11005157 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,08871113 0,10999224 ! gene silencing GO:0016458 41 27 0,000 0,08871113 0,10993298 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,09184361 0,11375353 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,09184361 0,1136923 ! phenol metabolic process GO:0018958 44 28 0,000 0,09184361 0,11363114 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,09184361 0,11357005 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,09184361 0,11350903 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,09184361 0,11344807 ! cell junction assembly GO:0034329 56 28 0,000 0,09184361 0,11338717 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,09184361 0,11332634 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,09184361 0,11326558 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,09184361 0,11320488 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,09184361 0,11314424 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,09184361 0,11308367 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,09184361 0,11302317 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,09184361 0,11296273 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,09184361 0,11290235 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,09184361 0,11284204 ! mesoderm formation GO:0001707 46 28 0,000 0,09184361 0,11278179 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,09184361 0,11272161 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,09184361 0,11266149 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,09184361 0,11260144 ! ensheathment of neurons GO:0007272 43 28 0,000 0,09184361 0,11254145 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,09184361 0,11248152 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,09184361 0,11242166 ! neural tube formation GO:0001841 41 28 0,000 0,09184361 0,11236186 ! placenta development GO:0001890 37 28 0,000 0,09184361 0,11230213 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,09496549 0,11605772 ! regulation of innate immune response GO:0045088 38 29 0,000 0,09496549 0,11599609 ! ovulation cycle process GO:0022602 41 29 0,000 0,09496549 0,11593452 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,09496549 0,11587302 ! protein targeting to membrane GO:0006612 53 29 0,000 0,09496549 0,11581158 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,09496549 0,1157502 ! mismatch repair GO:0006298 34 29 0,000 0,09496549 0,11568889 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,09496549 0,11562765 ! muscle cell development GO:0055001 38 29 0,000 0,09496549 0,11556647 ! formation of primary germ layer GO:0001704 48 29 0,000 0,09496549 0,11550536 ! telencephalon development GO:0021537 52 29 0,000 0,09496549 0,11544431 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,09496549 0,11538332 ! eye morphogenesis GO:0048592 51 29 0,000 0,09496549 0,1153224 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,09496549 0,11526155 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,09807682 0,11897505 ! organic anion transport GO:0015711 51 30 0,000 0,09807682 0,11891233 ! cholesterol transport GO:0030301 46 30 0,000 0,09807682 0,11884968 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,09807682 0,1187871 ! spliceosome assembly GO:0000245 49 30 0,000 0,09807682 0,11872458 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,09807682 0,11866212 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,09807682 0,11859974 ! ceramide metabolic process GO:0006672 43 30 0,000 0,09807682 0,11853741 ! ovulation cycle GO:0042698 43 30 0,000 0,09807682 0,11847516 ! hindbrain development GO:0030902 45 30 0,000 0,09807682 0,11841296 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,09807682 0,11835084 ! adult locomotory behavior GO:0008344 47 30 0,000 0,09807682 0,11828878 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,09807682 0,11822678 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,09807682 0,11816485 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,09807682 0,11810298 ! response to heat GO:0009408 41 30 0,000 0,09807682 0,11804118 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,09807682 0,11797944 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,09807682 0,11791777 ! negative regulation of secretion GO:0051048 49 31 0,000 0,10117764 0,12158232 ! glial cell differentiation GO:0010001 55 31 0,000 0,10117764 0,12151883 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,10117764 0,12145541 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,10117764 0,12139205 ! odontogenesis GO:0042476 50 31 0,000 0,10117764 0,12132876 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,10117764 0,12126554 ! segmentation GO:0035282 41 31 0,000 0,10117764 0,12120238 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,10117764 0,12113928 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,10117764 0,12107626 ! metanephros development GO:0001656 58 31 0,000 0,10117764 0,1210133 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,10117764 0,1209504 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,10117764 0,12088757 ! cell fate specification GO:0001708 37 31 0,000 0,10117764 0,1208248 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,10117764 0,1207621 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,10117764 0,12069946 ! RNA modification GO:0009451 40 31 0,000 0,10117764 0,12063689 ! regulation of muscle development GO:0048634 48 32 0,000 0,10426797 0,12425716 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,10426797 0,12419281 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,10426797 0,12412853 ! meiosis I GO:0007127 52 32 0,000 0,10426797 0,12406432 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,10426797 0,12400017 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,10426797 0,12393608 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,10426797 0,12387207 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,10426797 0,12380812 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,10426797 0,12374423 ! cytokine production GO:0001816 44 32 0,000 0,10426797 0,12368041 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,10426797 0,12361666 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,10426797 0,12355297 ! vesicle localization GO:0051648 47 32 0,000 0,10426797 0,12348935 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,10734785 0,12707156 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,10734785 0,1270062 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,10734785 0,1269409 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,10734785 0,12687567 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,10734785 0,1268105 ! sister chromatid segregation GO:0000819 46 33 0,000 0,10734785 0,12674541 ! ear morphogenesis GO:0042471 42 33 0,000 0,10734785 0,12668037 ! actomyosin structure organization GO:0031032 43 33 0,000 0,10734785 0,12661541 ! cell junction organization GO:0034330 63 33 0,000 0,10734785 0,12655051 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,10734785 0,12648568 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,10734785 0,12642092 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,10734785 0,12635622 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,10734785 0,12629159 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,10734785 0,12622702 ! lipid homeostasis GO:0055088 55 33 0,000 0,10734785 0,12616252 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,10734785 0,12609809 ! regulation of proteolysis GO:0030162 50 33 0,000 0,10734785 0,12603372 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,10734785 0,12596941 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,10734785 0,12590518 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,10734785 0,125841 ! mRNA catabolic process GO:0006402 48 34 0,000 0,11041732 0,12937332 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,11041732 0,12930745 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,11041732 0,12924164 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,11041732 0,1291759 ! feeding behavior GO:0007631 45 34 0,000 0,11041732 0,12911023 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,11041732 0,12904463 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,11041732 0,12897909 ! neuron migration GO:0001764 46 34 0,000 0,11041732 0,12891362 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,11041732 0,12884821 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,11041732 0,12878287 ! aerobic respiration GO:0009060 47 34 0,000 0,11041732 0,1287176 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,11041732 0,12865239 ! embryonic organ development GO:0048568 45 34 0,000 0,11041732 0,12858725 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,11041732 0,12852218 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,1134764 0,13201605 ! Notch signaling pathway GO:0007219 56 35 0,000 0,1134764 0,13194931 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,1134764 0,13188263 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,1134764 0,13181602 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,1134764 0,13174948 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,1134764 0,13168301 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,1134764 0,1316166 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,1134764 0,13155027 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,1134764 0,13148399 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,1134764 0,13141779 ! pigment metabolic process GO:0042440 61 35 0,000 0,1134764 0,13135165 ! protein homooligomerization GO:0051260 52 35 0,000 0,1134764 0,13128558 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,11652515 0,13474501 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,11652515 0,1346773 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,11652515 0,13460966 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,11652515 0,13454209 ! negative regulation of binding GO:0051100 58 36 0,000 0,11652515 0,13447458 ! organic ether metabolic process GO:0018904 46 36 0,000 0,11652515 0,13440714 ! neural tube development GO:0021915 50 36 0,000 0,11652515 0,13433977 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,11652515 0,13427246 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,11652515 0,13420523 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,11956358 0,13763575 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,11956358 0,1375669 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,11956358 0,13749811 ! learning GO:0007612 67 37 0,000 0,11956358 0,1374294 ! ion transmembrane transport GO:0034220 56 37 0,000 0,11956358 0,13736075 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,11956358 0,13729218 ! regulation of protein secretion GO:0050708 51 37 0,000 0,11956358 0,13722367 ! amino acid activation GO:0043038 52 37 0,000 0,11956358 0,13715523 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,11956358 0,13708685 ! gliogenesis GO:0042063 71 38 0,000 0,12259173 0,14048878 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,12259173 0,14041882 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,12259173 0,14034892 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,12259173 0,1402791 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,12259173 0,14020934 ! phagocytosis GO:0006909 60 38 0,000 0,12259173 0,14013966 ! mesenchymal cell development GO:0014031 64 38 0,000 0,12259173 0,14007004 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,12259173 0,14000049 ! maintenance of location in cell GO:0051651 69 38 0,000 0,12259173 0,13993101 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,12560965 0,14330466 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,12560965 0,14323361 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,12560965 0,14316263 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,12560965 0,14309172 ! male sex differentiation GO:0046661 53 39 0,000 0,12560965 0,14302089 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,12560965 0,14295012 ! chromatin remodeling GO:0006338 68 39 0,000 0,12560965 0,14287942 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,12560965 0,14280879 ! JNK cascade GO:0007254 54 39 0,000 0,12560965 0,14273824 ! synapse organization GO:0050808 55 39 0,000 0,12560965 0,14266775 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,12861735 0,1460118 ! response to calcium ion GO:0051592 58 40 0,000 0,12861735 0,14593977 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,12861735 0,14586781 ! regulation of tube size GO:0035150 60 40 0,000 0,12861735 0,14579592 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,12861735 0,1457241 ! peptide metabolic process GO:0006518 56 40 0,000 0,12861735 0,14565235 ! inner ear development GO:0048839 57 40 0,000 0,12861735 0,14558067 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,12861735 0,14550906 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,12861735 0,14543752 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,12861735 0,14536605 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,13161489 0,14868086 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,13161489 0,14860787 ! glucose transport GO:0015758 52 41 0,000 0,13161489 0,14853496 ! endosome transport GO:0016197 71 41 0,000 0,13161489 0,14846211 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,13161489 0,14838933 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,13161489 0,14831663 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,13161489 0,148244 ! biopolymer methylation GO:0043414 62 41 0,000 0,13161489 0,14817143 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,13161489 0,14809894 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,13460228 0,15138643 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,13460228 0,15131243 ! cellular component disassembly GO:0022411 64 42 0,000 0,13460228 0,15123852 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,13460228 0,15116467 ! hexose transport GO:0008645 54 42 0,000 0,13460228 0,15109089 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,13460228 0,15101719 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,13460228 0,15094356 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,13460228 0,15087 ! excretion GO:0007588 63 42 0,000 0,13460228 0,15079651 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,13460228 0,1507231 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,13460228 0,15064975 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,13460228 0,15057648 ! positive regulation of binding GO:0051099 59 43 0,000 0,13757956 0,15383228 ! leukocyte migration GO:0050900 60 43 0,000 0,13757956 0,15375753 ! neuromuscular process GO:0050905 79 43 0,000 0,13757956 0,15368286 ! tRNA processing GO:0008033 49 43 0,000 0,13757956 0,15360825 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,13757956 0,15353372 ! vesicle organization GO:0016050 79 43 0,000 0,13757956 0,15345926 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,13757956 0,15338488 ! methylation GO:0032259 64 43 0,000 0,13757956 0,15331056 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,14054678 0,15654121 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,14054678 0,15646544 ! glycolysis GO:0006096 53 44 0,000 0,14054678 0,15638974 ! regulation of action potential GO:0001508 71 44 0,000 0,14054678 0,15631411 ! regulation of ion transport GO:0043269 57 44 0,000 0,14054678 0,15623856 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,14054678 0,15616309 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,14054678 0,15608768 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,14054678 0,15601235 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,14054678 0,15593709 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,14054678 0,1558619 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,14054678 0,15578679 ! RNA catabolic process GO:0006401 64 45 0,000 0,14350395 0,158988 ! positive regulation of defense response GO:0031349 59 45 0,000 0,14350395 0,15891145 ! regulation of translational initiation GO:0006446 64 45 0,000 0,14350395 0,15883498 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,14350395 0,15875858 ! cell recognition GO:0008037 58 45 0,000 0,14350395 0,15868225 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,14645112 0,16186332 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,14645112 0,16178558 ! cell redox homeostasis GO:0045454 63 46 0,000 0,14645112 0,16170791 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,14645112 0,16163031 ! histone modification GO:0016570 68 46 0,000 0,14645112 0,16155279 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,14645112 0,16147535 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,14938831 0,16463494 ! viral infectious cycle GO:0019058 71 47 0,000 0,14938831 0,16455609 ! endocrine system development GO:0035270 83 47 0,000 0,14938831 0,16447732 ! covalent chromatin modification GO:0016569 75 47 0,000 0,14938831 0,16439862 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,14938831 0,16432 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,14938831 0,16424145 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,14938831 0,16416298 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,14938831 0,16408459 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,14938831 0,16400626 ! chloride transport GO:0006821 67 48 0,000 0,15231557 0,16714018 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,15231557 0,16706047 ! response to temperature stimulus GO:0009266 62 48 0,000 0,15231557 0,16698084 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,15231557 0,16690129 ! gastrulation GO:0007369 73 48 0,000 0,15231557 0,16682181 ! heart morphogenesis GO:0003007 65 48 0,000 0,15231557 0,16674241 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,15231557 0,16666309 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,15231557 0,16658384 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,15231557 0,16650466 ! regulation of endocytosis GO:0030100 63 48 0,000 0,15231557 0,16642556 ! nuclear export GO:0051168 69 48 0,000 0,15231557 0,16634654 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,15231557 0,16626759 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,15231557 0,16618871 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,15523292 0,16929147 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,15523292 0,16921124 ! sensory perception of smell GO:0007608 61 49 0,000 0,15523292 0,16913108 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,15523292 0,169051 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,15523292 0,168971 ! RNA elongation GO:0006354 62 49 0,000 0,15523292 0,16889107 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,15523292 0,16881121 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,15523292 0,16873143 ! maintenance of location GO:0051235 84 49 0,000 0,15523292 0,16865173 ! regulation of actin filament length GO:0030832 72 50 0,000 0,15814039 0,17172942 ! ear development GO:0043583 72 50 0,000 0,15814039 0,17164838 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,15814039 0,17156741 ! membrane fusion GO:0006944 80 50 0,000 0,15814039 0,17148652 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,15814039 0,17140571 ! positive regulation of growth GO:0045927 67 50 0,000 0,15814039 0,17132497 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,15814039 0,17124431 ! proton transport GO:0015992 75 50 0,000 0,15814039 0,17116372 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,15814039 0,17108321 ! positive regulation of secretion GO:0051047 71 51 0,000 0,16103803 0,17413609 ! hydrogen transport GO:0006818 77 51 0,000 0,16103803 0,17405426 ! muscle fiber development GO:0048747 74 51 0,000 0,16103803 0,17397251 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,16103803 0,17389083 ! adult behavior GO:0030534 80 51 0,000 0,16103803 0,17380923 ! transition metal ion transport GO:0000041 74 52 0,000 0,16392586 0,17684309 ! regulation of cellular component size GO:0032535 74 52 0,000 0,16392586 0,17676018 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,16392586 0,17667735 ! establishment of organelle localization GO:0051656 85 52 0,000 0,16392586 0,1765946 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,16680391 0,17961095 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,16680391 0,1795269 ! kidney development GO:0001822 90 53 0,000 0,16680391 0,17944293 ! single fertilization GO:0007338 59 53 0,000 0,16680391 0,17935904 ! cell projection assembly GO:0030031 76 53 0,000 0,16680391 0,17927523 ! amino acid transport GO:0006865 84 54 0,000 0,16967222 0,18227282 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,16967222 0,18218772 ! regulation of mitosis GO:0007088 84 54 0,000 0,16967222 0,18210271 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,16967222 0,18201777 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,16967222 0,18193292 ! DNA catabolic process GO:0006308 67 54 0,000 0,16967222 0,18184814 ! detection of external stimulus GO:0009581 66 54 0,000 0,16967222 0,18176344 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,16967222 0,18167882 ! exocytosis GO:0006887 74 55 0,000 0,17253082 0,18465374 ! mesoderm development GO:0007498 76 55 0,000 0,17253082 0,18456785 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,17253082 0,18448205 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,17253082 0,18439632 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,17537974 0,18735411 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,17537974 0,18726713 ! carbohydrate transport GO:0008643 74 57 0,000 0,17821901 0,19021055 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,17821901 0,19012233 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,17821901 0,19003418 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,17821901 0,18994612 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,17821901 0,18985814 ! camera-type eye development GO:0043010 88 57 0,000 0,17821901 0,18977025 ! secondary metabolic process GO:0019748 84 57 0,000 0,17821901 0,18968243 ! viral reproductive process GO:0022415 87 58 0,000 0,18104868 0,19260498 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,18104868 0,19251593 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,18104868 0,19242697 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,18104868 0,19233809 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,18386876 0,19524383 ! activation of MAPK activity GO:0000187 84 59 0,000 0,18386876 0,19515373 ! actin filament organization GO:0007015 95 59 0,000 0,18386876 0,19506372 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,18386876 0,19497379 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,18667929 0,19786284 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,18667929 0,1977717 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,18667929 0,19768065 ! regulation of heart contraction GO:0008016 91 60 0,000 0,18667929 0,19758967 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,18667929 0,19749879 ! fertilization GO:0009566 68 60 0,000 0,18667929 0,19740798 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,1894803 0,20027789 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,1894803 0,20018589 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,1894803 0,20009398 ! amine catabolic process GO:0009310 90 62 0,000 0,19227183 0,20294869 ! neurotransmitter transport GO:0006836 81 62 0,000 0,19227183 0,2028556 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,19227183 0,20276259 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,19227183 0,20266966 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,19227183 0,20257682 ! organelle localization GO:0051640 96 62 0,000 0,19227183 0,20248407 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,1950539 0,20531989 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,1950539 0,20522597 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,1950539 0,20513213 ! viral reproduction GO:0016032 92 63 0,000 0,1950539 0,20503838 ! appendage morphogenesis GO:0035107 93 64 0,000 0,19782655 0,20785795 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,19782655 0,20776304 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,19782655 0,20766821 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,19782655 0,20757348 ! hexose catabolic process GO:0019320 82 64 0,000 0,19782655 0,20747882 ! appendage development GO:0048736 94 65 0,000 0,2005898 0,21028102 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,2005898 0,21018522 ! defense response to bacterium GO:0042742 73 65 0,000 0,2005898 0,2100895 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,2005898 0,20999388 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,2005898 0,20989834 ! activation of immune response GO:0002253 83 65 0,000 0,2005898 0,20980289 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,2033437 0,2125866 ! antigen processing and presentation GO:0019882 96 66 0,000 0,2033437 0,21249001 ! axon guidance GO:0007411 99 66 0,000 0,2033437 0,21239351 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,2033437 0,2122971 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,20608827 0,21506489 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,20608827 0,21496735 ! acute inflammatory response GO:0002526 92 68 0,000 0,20882354 0,21772173 ! learning or memory GO:0007611 123 68 0,000 0,20882354 0,21762308 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,20882354 0,21752452 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,20882354 0,21742604 ! rhythmic process GO:0048511 105 68 0,000 0,20882354 0,21732766 ! inorganic anion transport GO:0015698 93 68 0,000 0,20882354 0,21722937 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,21154954 0,21996561 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,21154954 0,21986622 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,21154954 0,21976691 ! response to metal ion GO:0010038 103 70 0,000 0,2142663 0,22248871 ! humoral immune response GO:0006959 86 70 0,000 0,2142663 0,22238831 ! eye development GO:0001654 111 70 0,000 0,2142663 0,222288 ! amine transport GO:0015837 101 70 0,000 0,2142663 0,22218778 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,2142663 0,22208765 ! muscle cell differentiation GO:0042692 104 71 0,000 0,21697386 0,22479274 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,21697386 0,22469153 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,21697386 0,22459041 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,21697386 0,22448938 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,21967225 0,22717903 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,21967225 0,22707693 ! regulation of blood pressure GO:0008217 107 73 0,000 0,22236149 0,22975356 ! tube morphogenesis GO:0035239 118 73 0,000 0,22236149 0,22965039 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,22236149 0,22954731 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,22504161 0,23220983 ! digestion GO:0007586 97 74 0,000 0,22504161 0,2321057 ! blood coagulation GO:0007596 116 75 0,000 0,22771265 0,23475531 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,22771265 0,23465014 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,22771265 0,23454505 ! amine biosynthetic process GO:0009309 97 76 0,000 0,23037464 0,2371807 ! tRNA metabolic process GO:0006399 95 76 0,000 0,23037464 0,23707458 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,23302761 0,23969745 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,23302761 0,2395903 ! regulation of DNA binding GO:0051101 119 77 0,000 0,23302761 0,23948324 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,23302761 0,23937628 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,23302761 0,23926942 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,23302761 0,23916265 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,23567158 0,24176835 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,23567158 0,24166056 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,23567158 0,24155287 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,23830659 0,24414484 ! cellular respiration GO:0045333 107 79 0,000 0,23830659 0,24403613 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,23830659 0,24392753 ! regulation of lyase activity GO:0051339 133 79 0,000 0,23830659 0,24381902 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,23830659 0,24371061 ! chromatin assembly GO:0031497 102 80 0,000 0,24093267 0,24628673 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,24093267 0,24617731 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,24093267 0,246068 ! forebrain development GO:0030900 131 80 0,000 0,24093267 0,24595878 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,24354984 0,24852024 ! hemostasis GO:0007599 125 81 0,000 0,24354984 0,24841004 ! regulation of neurological system process GO:0031644 122 81 0,000 0,24354984 0,24829992 ! vitamin metabolic process GO:0006766 103 81 0,000 0,24354984 0,24818991 ! detection of stimulus GO:0051606 108 82 0,000 0,24615814 0,25073681 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,24875759 0,25327245 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,24875759 0,25316038 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,25134823 0,25568374 ! sterol metabolic process GO:0016125 120 84 0,000 0,25134823 0,25557071 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,25393009 0,25808184 ! rRNA metabolic process GO:0016072 107 85 0,000 0,25393009 0,25796784 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,25393009 0,25785395 ! regulation of membrane potential GO:0042391 128 85 0,000 0,25393009 0,25774016 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,25650319 0,26023702 ! nucleosome organization GO:0034728 114 87 0,000 0,25906756 0,26272283 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,25906756 0,26260704 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,25906756 0,26249136 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,25906756 0,26237577 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,25906756 0,26226029 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,26162323 0,26473094 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,26162323 0,26461453 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,26162323 0,26449821 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,26417024 0,26695586 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,26417024 0,26683862 ! regulation of T cell activation GO:0050863 128 89 0,000 0,26417024 0,26672149 ! hormone metabolic process GO:0042445 121 90 0,000 0,2667086 0,26916621 ! ATP metabolic process GO:0046034 137 91 0,000 0,26923836 0,2716001 ! response to virus GO:0009615 122 91 0,000 0,26923836 0,27148103 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,27175953 0,27390312 ! positive regulation of immune response GO:0050778 121 92 0,000 0,27175953 0,27378314 ! sulfur metabolic process GO:0006790 118 92 0,000 0,27175953 0,27366327 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,27427215 0,27607262 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,27427215 0,27595185 ! electron transport chain GO:0022900 123 94 0,000 0,27677624 0,27834952 ! regulation of binding GO:0051098 151 95 0,000 0,27927183 0,28073655 ! carboxylic acid transport GO:0046942 147 95 0,000 0,27927183 0,2806139 GO:0015849|organic acid transport, ! protein maturation GO:0051604 129 96 0,000 0,28175896 0,28298935 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,28423765 0,28535425 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,28423765 0,28522975 ! calcium ion transport GO:0006816 167 99 0,000 0,28916982 0,29005259 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,28916982 0,28992615 ! regulation of translation GO:0006417 151 100 0,000 0,29162335 0,2922587 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,29162335 0,29213141 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,29162335 0,29200423 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,29162335 0,29187716 ! divalent metal ion transport GO:0070838 171 100 0,000 0,29162335 0,2917502 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,29162335 0,29162335