pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6466-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 124 46 7,000 1,51E-09 3,69E-06 ! glycine biosynthetic process GO:0006545 7 5 3,000 1,391E-08 1,699E-05 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 6,000 2E-07 1,629E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 7,000 6,564E-07 4,009E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 6,000 7,576E-07 3,702E-04 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 4,000 7,645E-07 3,113E-04 ! negative regulation of kinase activity GO:0033673 145 70 6,000 8,366E-07 2,92E-04 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 3,000 8,867E-07 2,708E-04 ! negative regulation of transferase activity GO:0051348 155 74 6,000 1,225E-06 3,325E-04 ! serine family amino acid biosynthetic process GO:0009070 19 14 3,000 2,644E-06 6,458E-04 ! negative regulation of growth GO:0045926 168 85 6,000 3,138E-06 6,969E-04 ! hemoglobin biosynthetic process GO:0042541 8 5 2,000 3,827E-06 7,792E-04 ! positive regulation of chemokine production GO:0032722 8 5 2,000 3,827E-06 7,193E-04 ! positive regulation of cell migration GO:0030335 137 58 5,000 4,256E-06 7,426E-04 ! gland development GO:0048732 220 91 6,000 4,958E-06 8,074E-04 ! cytokine-mediated signaling pathway GO:0019221 112 61 5,000 5,732E-06 8,752E-04 ! glycine metabolic process GO:0006544 30 18 3,000 7,897E-06 1,135E-03 ! positive regulation of cell motion GO:0051272 157 65 5,000 8,321E-06 1,129E-03 ! negative regulation of cell growth GO:0030308 142 67 5,000 9,932E-06 1,277E-03 ! negative regulation of cell size GO:0045792 144 69 5,000 1,179E-05 1,44E-03 ! prostate gland development GO:0030850 14 7 2,000 1,325E-05 1,542E-03 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 1,325E-05 1,471E-03 ! cranial nerve morphogenesis GO:0021602 12 7 2,000 1,325E-05 1,408E-03 ! regulation of T cell differentiation GO:0045580 78 42 4,000 1,374E-05 1,399E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 4,000 1,938E-05 1,894E-03 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 2,109E-05 1,981E-03 ! hemoglobin metabolic process GO:0020027 14 8 2,000 2,109E-05 1,908E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 2,109E-05 1,84E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 2,109E-05 1,776E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 2,109E-05 1,717E-03 ! positive regulation of protein transport GO:0051222 80 46 4,000 2,162E-05 1,704E-03 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 2,649E-05 2,022E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 4,000 2,954E-05 2,187E-03 ! regulation of mast cell proliferation GO:0070666 89 49 4,000 2,954E-05 2,123E-03 ! response to hypoxia GO:0001666 178 81 5,000 2,966E-05 2,07E-03 ! response to oxygen levels GO:0070482 183 83 5,000 3,407E-05 2,312E-03 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 3,685E-05 2,433E-03 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of endothelial cell proliferation GO:0001936 60 27 3,000 4,301E-05 2,765E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 4,000 4,341E-05 2,719E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein transport GO:0051223 165 87 5,000 4,449E-05 2,717E-03 GO:0070201|regulation of establishment of protein localization, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 4,47E-05 2,663E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 4,47E-05 2,6E-03 ! regulation of angiogenesis GO:0045765 125 54 4,000 4,756E-05 2,702E-03 ! covalent chromatin modification GO:0016569 115 54 4,000 4,756E-05 2,641E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 2,000 6,113E-05 3,319E-03 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 2,000 6,113E-05 3,246E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 2,000 6,113E-05 3,177E-03 ! regulation of B cell activation GO:0050864 55 30 3,000 6,601E-05 3,359E-03 ! DNA catabolic process GO:0006308 94 60 4,000 7,925E-05 3,951E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 8,106E-05 3,961E-03 ! cranial nerve development GO:0021545 23 12 2,000 8,106E-05 3,883E-03 ! regulation of leukocyte migration GO:0002685 29 12 2,000 8,106E-05 3,808E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 8,106E-05 3,737E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of protein localization GO:0032880 188 97 5,000 8,191E-05 3,706E-03 ! regulation of chemokine production GO:0032642 18 13 2,000 1,048E-04 4,656E-03 ! endocrine pancreas development GO:0031018 25 13 2,000 1,048E-04 4,572E-03 ! regulation of monooxygenase activity GO:0032768 35 13 2,000 1,048E-04 4,492E-03 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 2,000 1,048E-04 4,415E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 3,000 1,092E-04 4,52E-03 ! serine family amino acid metabolic process GO:0009069 56 34 3,000 1,092E-04 4,445E-03 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 2,000 1,327E-04 5,314E-03 ! lung development GO:0030324 165 69 4,000 1,546E-04 6,091E-03 ! urogenital system development GO:0001655 149 69 4,000 1,546E-04 5,995E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 4,000 1,546E-04 5,901E-03 ! cell cycle checkpoint GO:0000075 145 71 4,000 1,77E-04 6,652E-03 ! respiratory tube development GO:0030323 171 72 4,000 1,891E-04 6,998E-03 ! heterophilic cell adhesion GO:0007157 43 16 2,000 2,019E-04 7,363E-03 ! regulation of neurotransmitter secretion GO:0046928 35 16 2,000 2,019E-04 7,254E-03 ! DNA replication initiation GO:0006270 28 16 2,000 2,019E-04 7,149E-03 ! regulation of T-helper cell differentiation GO:0045622 30 16 2,000 2,019E-04 7,047E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 2,019E-04 6,948E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! nucleus organization GO:0006997 73 40 3,000 2,078E-04 7,052E-03 ! respiratory system development GO:0060541 175 74 4,000 2,151E-04 7,198E-03 ! multicellular organismal metabolic process GO:0044236 64 41 3,000 2,29E-04 7,56E-03 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 2,000 2,439E-04 7,943E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 2,439E-04 7,839E-03 ! regulation of intracellular protein transport GO:0033157 86 42 3,000 2,517E-04 7,984E-03 ! regulation of T cell proliferation GO:0042129 80 43 3,000 2,759E-04 8,641E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 2,911E-04 9,001E-03 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 2,000 2,911E-04 8,888E-03 ! nerve development GO:0021675 34 18 2,000 2,911E-04 8,778E-03 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 3,000 3,017E-04 8,989E-03 ! positive regulation of phosphorylation GO:0042327 149 81 4,000 3,282E-04 9,661E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 3,293E-04 9,576E-03 ! positive regulation of translation GO:0045727 31 19 2,000 3,438E-04 9,88E-03 ! pigmentation during development GO:0048066 42 19 2,000 3,438E-04 9,765E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 3,586E-04 0,010069 ! pigmentation GO:0043473 103 46 3,000 3,586E-04 9,955E-03 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 4,000 3,676E-04 0,01008904 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 4,023E-04 0,01091887 ! pancreas development GO:0031016 40 20 2,000 4,023E-04 0,01079888 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 4,023E-04 0,0106815 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 4,023E-04 0,01056665 ! response to alkaloid GO:0043279 38 20 2,000 4,023E-04 0,01045424 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 2,000 4,023E-04 0,01034419 ! negative regulation of T cell activation GO:0050868 41 20 2,000 4,023E-04 0,01023644 ! JAK-STAT cascade GO:0007259 82 48 3,000 4,227E-04 0,01064584 ! regulation of neurotransmitter transport GO:0051588 44 21 2,000 4,668E-04 0,01163571 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 4,668E-04 0,01151818 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 2,000 4,668E-04 0,011403 ! one-carbon metabolic process GO:0006730 167 88 4,000 4,815E-04 0,01164567 ! endocrine system development GO:0035270 109 50 3,000 4,946E-04 0,01184617 ! positive regulation of helicase activity GO:0051096 12 5 1,000 5,253E-04 0,01246012 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,253E-04 0,01234031 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 1,000 5,253E-04 0,01222279 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 5,253E-04 0,01210748 ! hypothalamus development GO:0021854 9 5 1,000 5,253E-04 0,01199432 ! regulation of collagen biosynthetic process GO:0032965 7 5 1,000 5,253E-04 0,01188326 ! serotonin receptor signaling pathway GO:0007210 10 5 1,000 5,253E-04 0,01177424 ! response to protozoan GO:0001562 13 5 1,000 5,253E-04 0,0116672 ! positive regulation of glycolysis GO:0045821 13 5 1,000 5,253E-04 0,01156209 ! positive regulation of neurotransmitter secretion GO:0001956 11 5 1,000 5,253E-04 0,01145886 ! epithelial cell proliferation GO:0050673 9 5 1,000 5,253E-04 0,01135746 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 5,253E-04 0,01125783 ! neutrophil mediated immunity GO:0002446 7 5 1,000 5,253E-04 0,01115994 ! microvillus organization GO:0032528 8 5 1,000 5,253E-04 0,01106373 GO:0030033|microvillus assembly, ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 1,000 5,253E-04 0,01096917 ! mRNA transcription GO:0009299 10 5 1,000 5,253E-04 0,01087621 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 5,253E-04 0,01078481 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 5,253E-04 0,01069494 ! substrate-bound cell migration, cell extension GO:0006930 6 5 1,000 5,253E-04 0,01060655 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 5,253E-04 0,01051961 ! positive regulation of vasoconstriction GO:0045907 10 5 1,000 5,253E-04 0,01043409 ! activated T cell proliferation GO:0050798 16 5 1,000 5,253E-04 0,01034994 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 5,253E-04 0,01026714 ! regulation of sensory perception GO:0051931 8 5 1,000 5,253E-04 0,01018566 GO:0051930|regulation of sensory perception of pain, ! protein insertion into membrane GO:0051205 17 5 1,000 5,253E-04 0,01010545 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 5,253E-04 0,0100265 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 5,253E-04 9,949E-03 GO:0048103|somatic stem cell division, ! organ regeneration GO:0031100 7 5 1,000 5,253E-04 9,872E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 5,375E-04 0,01002467 ! apoptotic nuclear changes GO:0030262 34 22 2,000 5,375E-04 9,949E-03 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 2,000 5,375E-04 9,874E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 5,375E-04 9,8E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of intracellular transport GO:0032388 42 22 2,000 5,375E-04 9,728E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 5,375E-04 9,656E-03 ! positive regulation of B cell activation GO:0050871 42 22 2,000 5,375E-04 9,586E-03 ! cellular amino acid biosynthetic process GO:0008652 80 52 3,000 5,748E-04 0,01017575 ! histone modification GO:0016570 104 52 3,000 5,748E-04 0,01010255 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 2,000 6,149E-04 0,01072914 ! regulation of chemotaxis GO:0050920 45 23 2,000 6,149E-04 0,01065304 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 3,000 6,182E-04 0,01063542 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 6,201E-04 0,0105937 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 3,000 6,638E-04 0,01126217 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 6,989E-04 0,01177529 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 6,989E-04 0,01169463 ! regulation of T cell activation GO:0050863 175 96 4,000 7,165E-04 0,01190726 ! regulation of DNA metabolic process GO:0051052 188 97 4,000 7,51E-04 0,01239608 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 7,842E-04 0,01285764 ! forebrain regionalization GO:0021871 9 6 1,000 7,842E-04 0,01277193 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 1,000 7,842E-04 0,01268734 ! erythrocyte maturation GO:0043249 8 6 1,000 7,842E-04 0,01260388 ! embryonic hemopoiesis GO:0035162 16 6 1,000 7,842E-04 0,0125215 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 1,000 7,842E-04 0,01244019 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 1,000 7,842E-04 0,01235993 GO:0033135|regulation of peptidyl-serine phosphorylation, ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 7,842E-04 0,0122807 ! T cell mediated immunity GO:0002456 17 6 1,000 7,842E-04 0,01220248 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 7,842E-04 0,01212525 ! regulation of collagen metabolic process GO:0010712 10 6 1,000 7,842E-04 0,01204899 ! neural nucleus development GO:0048857 19 6 1,000 7,842E-04 0,01197368 ! astrocyte development GO:0014002 16 6 1,000 7,842E-04 0,01189931 ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 7,842E-04 0,01182586 ! Schwann cell development GO:0014044 15 6 1,000 7,842E-04 0,01175331 ! oxygen homeostasis GO:0032364 10 6 1,000 7,842E-04 0,01168164 ! neutrophil homeostasis GO:0001780 11 6 1,000 7,842E-04 0,01161084 ! salivary gland morphogenesis GO:0007435 14 6 1,000 7,842E-04 0,0115409 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 1,000 7,842E-04 0,01147179 ! ectodermal gut morphogenesis GO:0048567 16 6 1,000 7,842E-04 0,01140351 GO:0007439|ectodermal gut development, ! organ or tissue specific immune response GO:0002251 8 6 1,000 7,842E-04 0,01133603 ! negative regulation of B cell activation GO:0050869 14 6 1,000 7,842E-04 0,01126935 ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 7,899E-04 0,01128538 ! regulation of behavior GO:0050795 48 25 2,000 7,899E-04 0,01121977 ! regulation of alpha-beta T cell activation GO:0046634 48 25 2,000 7,899E-04 0,01115491 ! lymphocyte proliferation GO:0046651 55 25 2,000 7,899E-04 0,0110908 ! positive regulation of protein secretion GO:0050714 41 25 2,000 7,899E-04 0,01102743 ! regulation of intracellular transport GO:0032386 108 57 3,000 8,151E-04 0,01131373 ! myelination GO:0042552 50 26 2,000 8,882E-04 0,0122586 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 9,938E-04 0,01363967 ! leukocyte proliferation GO:0070661 59 27 2,000 9,938E-04 0,01356347 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 9,938E-04 0,01348811 ! positive regulation of secretion GO:0051047 110 61 3,000 1,052E-03 0,01420583 ! regulation of helicase activity GO:0051095 16 7 1,000 1,093E-03 0,01466569 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,093E-03 0,01458555 ! mRNA stabilization GO:0048255 18 7 1,000 1,093E-03 0,01450628 GO:0043489|RNA stabilization, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 1,093E-03 0,01442787 ! positive regulation of neurotransmitter transport GO:0051590 16 7 1,000 1,093E-03 0,0143503 ! regulation of dopamine metabolic process GO:0042053 12 7 1,000 1,093E-03 0,01427356 GO:0042069|regulation of catecholamine metabolic process, ! spinal cord patterning GO:0021511 14 7 1,000 1,093E-03 0,01419764 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 1,000 1,093E-03 0,01412252 ! maintenance of protein location in nucleus GO:0051457 19 7 1,000 1,093E-03 0,01404819 ! negative regulation of DNA recombination GO:0045910 16 7 1,000 1,093E-03 0,01397464 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 1,093E-03 0,01390185 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 1,093E-03 0,01382982 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 1,093E-03 0,01375853 ! peptidyl-threonine modification GO:0018210 26 7 1,000 1,093E-03 0,01368798 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 1,000 1,093E-03 0,01361814 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 1,000 1,093E-03 0,01354901 ! defense response to Gram-negative bacterium GO:0050829 10 7 1,000 1,093E-03 0,01348058 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 1,107E-03 0,01359085 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 1,107E-03 0,0135229 ! positive regulation of T cell differentiation GO:0045582 48 28 2,000 1,107E-03 0,01345562 ! regulation of homeostatic process GO:0032844 148 62 3,000 1,119E-03 0,01352946 ! skeletal system morphogenesis GO:0048705 118 63 3,000 1,188E-03 0,0142938 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 2,000 1,228E-03 0,01470798 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 1,228E-03 0,01463623 ! neurotransmitter secretion GO:0007269 55 30 2,000 1,357E-03 0,01609656 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,45E-03 0,01710967 ! male meiosis GO:0007140 9 8 1,000 1,45E-03 0,01702741 ! regulation of cellular amine metabolic process GO:0033238 13 8 1,000 1,45E-03 0,01694594 ! macrophage chemotaxis GO:0048246 12 8 1,000 1,45E-03 0,01686525 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,45E-03 0,01678532 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,45E-03 0,01670614 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 1,45E-03 0,01662771 ! astrocyte differentiation GO:0048708 19 8 1,000 1,45E-03 0,01655001 ! ER overload response GO:0006983 13 8 1,000 1,45E-03 0,01647303 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,45E-03 0,01639677 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,45E-03 0,01632121 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,45E-03 0,01624634 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 1,000 1,45E-03 0,01617216 ! Schwann cell differentiation GO:0014037 21 8 1,000 1,45E-03 0,01609865 ! gas homeostasis GO:0033483 14 8 1,000 1,45E-03 0,0160258 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 1,45E-03 0,01595361 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 1,000 1,45E-03 0,01588207 GO:0002688|regulation of leukocyte chemotaxis, ! myeloid cell homeostasis GO:0002262 15 8 1,000 1,45E-03 0,01581117 ! behavioral response to nicotine GO:0035095 12 8 1,000 1,45E-03 0,0157409 ! cell junction assembly GO:0034329 85 31 2,000 1,495E-03 0,01615682 ! iron ion homeostasis GO:0055072 60 31 2,000 1,495E-03 0,01608565 ! erythrocyte differentiation GO:0030218 62 31 2,000 1,495E-03 0,0160151 ! ensheathment of neurons GO:0007272 64 31 2,000 1,495E-03 0,01594516 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 1,495E-03 0,01587584 ! collagen metabolic process GO:0032963 49 32 2,000 1,64E-03 0,01734865 ! peripheral nervous system development GO:0007422 68 32 2,000 1,64E-03 0,01727387 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 2,000 1,64E-03 0,01719974 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,64E-03 0,01712623 ! homeostasis of number of cells GO:0048872 131 69 3,000 1,666E-03 0,01731777 ! positive regulation of gene-specific transcription GO:0043193 70 33 2,000 1,795E-03 0,01857893 ! leukocyte chemotaxis GO:0030595 55 33 2,000 1,795E-03 0,01850053 GO:0060326|cell chemotaxis, ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,855E-03 0,01904058 ! cell proliferation in forebrain GO:0021846 18 9 1,000 1,855E-03 0,01896091 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 1,000 1,855E-03 0,01888191 GO:0010469|regulation of receptor activity, ! induction of positive chemotaxis GO:0050930 17 9 1,000 1,855E-03 0,01880356 ! regulation of glycolysis GO:0006110 20 9 1,000 1,855E-03 0,01872586 ! cerebral cortex cell migration GO:0021795 18 9 1,000 1,855E-03 0,0186488 ! microtubule bundle formation GO:0001578 22 9 1,000 1,855E-03 0,01857237 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,855E-03 0,01849656 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,855E-03 0,01842138 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 1,855E-03 0,01834679 ! erythrocyte development GO:0048821 17 9 1,000 1,855E-03 0,01827282 ! regulation of T-helper 1 type immune response GO:0002825 12 9 1,000 1,855E-03 0,01819943 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 1,855E-03 0,01812663 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,855E-03 0,01805442 ! regulation of amino acid transport GO:0051955 12 9 1,000 1,855E-03 0,01798277 ! glial cell differentiation GO:0010001 67 34 2,000 1,958E-03 0,01890568 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 2,000 2,13E-03 0,02048618 ! telencephalon development GO:0021537 81 35 2,000 2,13E-03 0,02040584 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 3,000 2,155E-03 0,02056517 ! regulation of transcription factor activity GO:0051090 137 75 3,000 2,264E-03 0,02151655 GO:0090046|regulation of transcription regulator activity, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 1,000 2,308E-03 0,0218499 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 2,308E-03 0,02176553 ! smoothened signaling pathway GO:0007224 18 10 1,000 2,308E-03 0,02168182 ! lung alveolus development GO:0048286 26 10 1,000 2,308E-03 0,02159875 ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 2,308E-03 0,02151631 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 2,308E-03 0,0214345 ! myeloid leukocyte mediated immunity GO:0002444 14 10 1,000 2,308E-03 0,02135331 ! epithelial cell development GO:0002064 21 10 1,000 2,308E-03 0,02127273 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 2,308E-03 0,02119276 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 2,308E-03 0,02111338 ! motor axon guidance GO:0008045 22 10 1,000 2,308E-03 0,0210346 ! regulation of bone resorption GO:0045124 25 10 1,000 2,308E-03 0,02095641 ! positive regulation of interleukin-6 production GO:0032755 14 10 1,000 2,308E-03 0,02087879 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 2,308E-03 0,02080175 ! salivary gland development GO:0007431 28 10 1,000 2,308E-03 0,02072527 ! positive regulation of acute inflammatory response GO:0002675 18 10 1,000 2,308E-03 0,02064935 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 2,308E-03 0,02057399 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 1,000 2,308E-03 0,02049917 ! positive regulation of amine transport GO:0051954 17 10 1,000 2,308E-03 0,0204249 ! response to nicotine GO:0035094 20 10 1,000 2,308E-03 0,02035117 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 2,000 2,311E-03 0,02030968 ! embryonic organ development GO:0048568 67 36 2,000 2,311E-03 0,02023689 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 2,000 2,502E-03 0,02182621 ! cell junction organization GO:0034330 96 37 2,000 2,502E-03 0,02174853 ! tissue remodeling GO:0048771 78 37 2,000 2,502E-03 0,02167141 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 2,502E-03 0,02159483 ! negative regulation of cell activation GO:0050866 69 37 2,000 2,502E-03 0,0215188 ! positive regulation of lymphocyte activation GO:0051251 142 78 3,000 2,611E-03 0,02238557 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 2,000 2,701E-03 0,02307556 ! embryonic skeletal system morphogenesis GO:0048704 68 38 2,000 2,701E-03 0,02299515 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 2,701E-03 0,02291531 ! negative regulation of muscle development GO:0048635 27 11 1,000 2,807E-03 0,023726 ! neuron fate specification GO:0048665 18 11 1,000 2,807E-03 0,02364419 ! telencephalon cell migration GO:0022029 23 11 1,000 2,807E-03 0,02356294 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 2,807E-03 0,02348224 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,807E-03 0,0234021 ! blood vessel remodeling GO:0001974 30 11 1,000 2,807E-03 0,0233225 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 2,807E-03 0,02324344 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,807E-03 0,02316491 ! melanocyte differentiation GO:0030318 20 11 1,000 2,807E-03 0,02308692 GO:0050931|pigment cell differentiation, ! substrate-bound cell migration GO:0006929 14 11 1,000 2,807E-03 0,02300944 ! adult heart development GO:0007512 16 11 1,000 2,807E-03 0,02293249 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 1,000 2,807E-03 0,02285605 ! embryonic gut development GO:0048566 19 11 1,000 2,807E-03 0,02278011 ! regulation of organic acid transport GO:0032890 19 11 1,000 2,807E-03 0,02270468 ! carbohydrate homeostasis GO:0033500 59 39 2,000 2,911E-03 0,02346956 GO:0042593|glucose homeostasis, ! erythrocyte homeostasis GO:0034101 75 39 2,000 2,911E-03 0,02339236 ! positive regulation of leukocyte proliferation GO:0070665 70 39 2,000 2,911E-03 0,02331566 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 93 40 2,000 3,13E-03 0,02498921 ! regulation of action potential in neuron GO:0019228 80 40 2,000 3,13E-03 0,02490781 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 3,352E-03 0,02658626 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 3,352E-03 0,02650022 GO:0050927|positive regulation of positive chemotaxis, ! T cell proliferation GO:0042098 32 12 1,000 3,352E-03 0,02641474 ! ventral spinal cord development GO:0021517 25 12 1,000 3,352E-03 0,02632981 ! oligodendrocyte differentiation GO:0048709 17 12 1,000 3,352E-03 0,02624541 ! focal adhesion formation GO:0048041 37 12 1,000 3,352E-03 0,02616156 ! forebrain cell migration GO:0021885 24 12 1,000 3,352E-03 0,02607825 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 1,000 3,352E-03 0,02599546 GO:0002717|positive regulation of natural killer cell mediated immunity, ! histone acetylation GO:0016573 27 12 1,000 3,352E-03 0,02591319 ! autonomic nervous system development GO:0048483 24 12 1,000 3,352E-03 0,02583145 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 3,352E-03 0,02575022 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,352E-03 0,0256695 ! leukocyte mediated cytotoxicity GO:0001909 28 12 1,000 3,352E-03 0,02558928 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 3,352E-03 0,02550956 ! defense response to Gram-positive bacterium GO:0050830 14 12 1,000 3,352E-03 0,02543034 ! embryonic placenta development GO:0001892 21 12 1,000 3,352E-03 0,02535161 ! localization within membrane GO:0051668 26 12 1,000 3,352E-03 0,02527336 ! gliogenesis GO:0042063 91 41 2,000 3,359E-03 0,0252499 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 2,000 3,598E-03 0,02696373 ! regulation of protein secretion GO:0050708 77 42 2,000 3,598E-03 0,02688127 ! dorsal/ventral pattern formation GO:0009953 75 42 2,000 3,598E-03 0,02679931 ! positive regulation of cell activation GO:0050867 161 86 3,000 3,715E-03 0,02758754 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of transcription factor activity GO:0051091 71 43 2,000 3,847E-03 0,02848149 GO:0090047|positive regulation of transcription regulator activity, ! regulation of myeloid cell differentiation GO:0045637 105 43 2,000 3,847E-03 0,02839544 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 1,000 3,942E-03 0,02900857 ! exocrine system development GO:0035272 34 13 1,000 3,942E-03 0,02892145 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 3,942E-03 0,02883486 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of natural killer cell mediated immunity GO:0002715 28 13 1,000 3,942E-03 0,02874879 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! histone methylation GO:0016571 29 13 1,000 3,942E-03 0,02866323 ! chromatin silencing GO:0006342 29 13 1,000 3,942E-03 0,02857817 ! gland morphogenesis GO:0022612 31 13 1,000 3,942E-03 0,02849362 ! regulation of acute inflammatory response GO:0002673 24 13 1,000 3,942E-03 0,02840957 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 3,942E-03 0,02832601 ! regulation of mRNA stability GO:0043488 32 13 1,000 3,942E-03 0,02824294 ! digestive tract morphogenesis GO:0048546 31 13 1,000 3,942E-03 0,02816036 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! amine biosynthetic process GO:0009309 146 88 3,000 4,034E-03 0,02873001 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 4,107E-03 0,02916476 ! regulation of DNA binding GO:0051101 167 89 3,000 4,2E-03 0,02973864 ! tube morphogenesis GO:0035239 194 89 3,000 4,2E-03 0,02965269 ! positive regulation of protein modification process GO:0031401 156 90 3,000 4,37E-03 0,03076767 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 4,377E-03 0,03072368 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 2,000 4,377E-03 0,03063564 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 1,000 4,577E-03 0,03194847 GO:0046579|positive regulation of Ras protein signal transduction, ! hair follicle morphogenesis GO:0031069 27 14 1,000 4,577E-03 0,03185744 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 4,577E-03 0,03176694 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 1,000 4,577E-03 0,03167695 ! regulation of T-helper 2 type immune response GO:0002828 25 14 1,000 4,577E-03 0,03158747 ! regulation of RNA stability GO:0043487 33 14 1,000 4,577E-03 0,03149849 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 4,577E-03 0,03141001 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 4,657E-03 0,03186741 ! leukocyte migration GO:0050900 75 46 2,000 4,657E-03 0,03177839 ! cell growth GO:0016049 90 46 2,000 4,657E-03 0,03168987 ! regulation of cell morphogenesis GO:0022604 243 93 3,000 4,91E-03 0,03331693 ! neural tube development GO:0021915 91 47 2,000 4,948E-03 0,0334832 ! response to insulin stimulus GO:0032868 98 47 2,000 4,948E-03 0,03339071 ! positive regulation of cell cycle GO:0045787 96 48 2,000 5,249E-03 0,03532899 ! positive regulation of defense response GO:0031349 88 48 2,000 5,249E-03 0,03523193 ! regulation of JAK-STAT cascade GO:0046425 76 48 2,000 5,249E-03 0,0351354 ! cellular component disassembly GO:0022411 89 48 2,000 5,249E-03 0,0350394 ! positive regulation of DNA binding GO:0043388 83 48 2,000 5,249E-03 0,03494393 ! regulation of adaptive immune response GO:0002819 92 48 2,000 5,249E-03 0,03484897 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 5,256E-03 0,03479748 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 5,256E-03 0,03470343 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 1,000 5,256E-03 0,03460989 ! regulation of mRNA processing GO:0050684 26 15 1,000 5,256E-03 0,03451685 ! regulation of exocytosis GO:0017157 26 15 1,000 5,256E-03 0,03442431 ! G1/S transition checkpoint GO:0031575 37 15 1,000 5,256E-03 0,03433227 ! histone deacetylation GO:0016575 24 15 1,000 5,256E-03 0,03424072 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 5,256E-03 0,03414965 ! muscle maintenance GO:0046716 26 15 1,000 5,256E-03 0,03405907 ! dopamine metabolic process GO:0042417 35 15 1,000 5,256E-03 0,03396897 ! cell killing GO:0001906 32 15 1,000 5,256E-03 0,03387934 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 5,256E-03 0,03379018 ! response to calcium ion GO:0051592 94 49 2,000 5,562E-03 0,03566373 ! transcription initiation GO:0006352 171 97 3,000 5,696E-03 0,03642644 ! regulation of action potential GO:0001508 102 50 2,000 5,885E-03 0,03754065 ! activation of caspase activity GO:0006919 95 50 2,000 5,885E-03 0,03744289 ! positive regulation of cytokine production GO:0001819 94 50 2,000 5,885E-03 0,03734563 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 5,978E-03 0,03783451 ! positive regulation of cell size GO:0045793 29 16 1,000 5,978E-03 0,03773675 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 5,978E-03 0,03763949 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 1,000 5,978E-03 0,03754273 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 1,000 5,978E-03 0,03744647 ! pituitary gland development GO:0021983 30 16 1,000 5,978E-03 0,0373507 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 5,978E-03 0,03725542 ! positive regulation of cytokine secretion GO:0050715 29 16 1,000 5,978E-03 0,03716062 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 5,978E-03 0,0370663 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 1,000 5,978E-03 0,03697246 ! viral infectious cycle GO:0019058 104 51 2,000 6,22E-03 0,03837176 ! negative regulation of immune system process GO:0002683 101 51 2,000 6,22E-03 0,03827511 ! positive regulation of binding GO:0051099 88 52 2,000 6,566E-03 0,04030041 ! DNA-dependent DNA replication GO:0006261 82 52 2,000 6,566E-03 0,04019941 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 2,000 6,566E-03 0,04009891 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 6,566E-03 0,03999891 ! positive regulation of cell killing GO:0031343 36 17 1,000 6,742E-03 0,04097489 ! negative regulation of hormone secretion GO:0046888 26 17 1,000 6,742E-03 0,04087321 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 6,742E-03 0,04077204 ! glial cell development GO:0021782 28 17 1,000 6,742E-03 0,04067137 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 1,000 6,742E-03 0,04057119 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 6,742E-03 0,04047151 ! regulation of survival gene product expression GO:0045884 38 17 1,000 6,742E-03 0,04037231 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 6,742E-03 0,0402736 GO:0031114|regulation of microtubule depolymerization, ! DNA unwinding during replication GO:0006268 26 17 1,000 6,742E-03 0,04017538 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 6,742E-03 0,04007763 ! chromatin remodeling GO:0006338 122 53 2,000 6,922E-03 0,0410469 ! activation of phospholipase C activity GO:0007202 110 54 2,000 7,291E-03 0,0431252 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 2,000 7,291E-03 0,04302104 ! regulation of cell shape GO:0008360 142 54 2,000 7,291E-03 0,04291737 ! epithelial tube morphogenesis GO:0060562 114 54 2,000 7,291E-03 0,04281421 ! positive regulation of anti-apoptosis GO:0045768 47 18 1,000 7,549E-03 0,04422544 ! limbic system development GO:0021761 40 18 1,000 7,549E-03 0,04411964 ! heart looping GO:0001947 34 18 1,000 7,549E-03 0,04401434 ! epidermis morphogenesis GO:0048730 43 18 1,000 7,549E-03 0,04390955 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 7,549E-03 0,04380525 ! neural crest cell migration GO:0001755 41 18 1,000 7,549E-03 0,04370145 ! regulation of immunoglobulin production GO:0002637 49 18 1,000 7,549E-03 0,04359813 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 7,549E-03 0,04349531 ! defense response to virus GO:0051607 43 18 1,000 7,549E-03 0,04339297 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 7,549E-03 0,0432911 ! positive regulation of phospholipase activity GO:0010518 111 55 2,000 7,67E-03 0,04388273 ! cell maturation GO:0048469 107 55 2,000 7,67E-03 0,0437802 ! response to UV GO:0009411 120 55 2,000 7,67E-03 0,04367815 ! RNA elongation GO:0006354 90 56 2,000 8,061E-03 0,04579805 ! memory GO:0007613 34 19 1,000 8,397E-03 0,04759363 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 8,397E-03 0,04748346 ! cerebral cortex development GO:0021987 40 19 1,000 8,397E-03 0,0473738 ! neuromuscular junction development GO:0007528 43 19 1,000 8,397E-03 0,04726464 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 8,397E-03 0,04715599 ! proximal/distal pattern formation GO:0009954 33 19 1,000 8,397E-03 0,04704783 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 1,000 8,397E-03 0,04694017 ! embryonic organ morphogenesis GO:0048562 34 19 1,000 8,397E-03 0,046833 ! peptide hormone secretion GO:0030072 32 19 1,000 8,397E-03 0,04672632 ! regulation of bone remodeling GO:0046850 143 57 2,000 8,464E-03 0,04699228 ! positive regulation of caspase activity GO:0043280 108 57 2,000 8,464E-03 0,04688572 GO:0010952|positive regulation of peptidase activity, ! regulation of phospholipase activity GO:0010517 113 57 2,000 8,464E-03 0,04677964 ! nucleotide-excision repair GO:0006289 91 57 2,000 8,464E-03 0,04667404 ! regulation of tissue remodeling GO:0034103 146 58 2,000 8,878E-03 0,0488478 ! positive regulation of lipase activity GO:0060193 115 58 2,000 8,878E-03 0,04873803 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 9,285E-03 0,05085846 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 9,285E-03 0,05074468 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 1,000 9,285E-03 0,05063141 ! protein amino acid deacetylation GO:0006476 34 20 1,000 9,285E-03 0,05051865 ! protein amino acid acetylation GO:0006473 41 20 1,000 9,285E-03 0,05040639 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 9,285E-03 0,05029462 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 9,285E-03 0,05018335 ! DNA duplex unwinding GO:0032508 30 20 1,000 9,285E-03 0,05007257 GO:0032392|DNA geometric change, ! actin filament bundle formation GO:0051017 47 20 1,000 9,285E-03 0,04996228 ! peptide secretion GO:0002790 38 20 1,000 9,285E-03 0,04985247 ! regulation of interleukin-2 production GO:0032663 39 20 1,000 9,285E-03 0,04974314 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 1,000 9,285E-03 0,0496343 ! regulation of neurotransmitter levels GO:0001505 113 60 2,000 9,741E-03 0,05196041 ! lipid modification GO:0030258 112 60 2,000 9,741E-03 0,0518472 ! kidney development GO:0001822 133 60 2,000 9,741E-03 0,05173449 ! regulation of cell killing GO:0031341 46 21 1,000 0,01021306 0,05412259 ! hormone secretion GO:0046879 39 21 1,000 0,01021306 0,05400544 ! lipid phosphorylation GO:0046834 43 21 1,000 0,01021306 0,0538888 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 0,01021306 0,05377266 ! regulation of vasoconstriction GO:0019229 40 21 1,000 0,01021306 0,05365702 ! diencephalon development GO:0021536 36 21 1,000 0,01021306 0,05354187 ! negative regulation of angiogenesis GO:0016525 49 21 1,000 0,01021306 0,05342722 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 0,01021306 0,05331306 ! positive regulation of inflammatory response GO:0050729 41 21 1,000 0,01021306 0,05319939 ! positive regulation of osteoblast differentiation GO:0045669 52 21 1,000 0,01021306 0,0530862 ! collagen catabolic process GO:0030574 29 21 1,000 0,01021306 0,05297349 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 0,01021306 0,05286126 ! viral reproductive process GO:0022415 132 62 2,000 0,01065195 0,05501632 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 0,01118061 0,05762498 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 1,000 0,01118061 0,05750366 ! hindlimb morphogenesis GO:0035137 47 22 1,000 0,01118061 0,05738286 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 0,01118061 0,05726256 ! ureteric bud development GO:0001657 50 22 1,000 0,01118061 0,05714276 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 0,01118061 0,05702347 ! G1 phase GO:0051318 44 22 1,000 0,01118061 0,05690467 ! detection of chemical stimulus GO:0009593 42 22 1,000 0,01118061 0,05678636 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 0,01118061 0,05666855 ! regulation of cytokine secretion GO:0050707 41 22 1,000 0,01118061 0,05655122 ! response to cytokine stimulus GO:0034097 69 22 1,000 0,01118061 0,05643438 ! somatic diversification of immunoglobulins GO:0016445 55 22 1,000 0,01118061 0,05631802 ! gut development GO:0048565 44 22 1,000 0,01118061 0,05620214 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 0,01161035 0,05824247 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 0,01161035 0,05812312 ! positive regulation of DNA replication GO:0045740 44 23 1,000 0,01218688 0,06088454 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 0,01218688 0,06076029 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 0,01218688 0,06063654 ! viral genome replication GO:0019079 44 23 1,000 0,01218688 0,0605133 ! regeneration GO:0031099 42 23 1,000 0,01218688 0,06039055 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 0,01218688 0,0602683 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 1,000 0,01218688 0,06014655 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 0,01218688 0,06002529 ! regulation of interleukin-6 production GO:0032675 31 23 1,000 0,01218688 0,05990451 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 0,01218688 0,05978422 ! hormone transport GO:0009914 41 23 1,000 0,01218688 0,05966441 ! response to molecule of bacterial origin GO:0002237 40 23 1,000 0,01218688 0,05954508 ! regulation of cytokine biosynthetic process GO:0042035 108 66 2,000 0,01261684 0,06152281 ! regulation of lipid metabolic process GO:0019216 132 66 2,000 0,01261684 0,06140026 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 0,01261684 0,06127819 ! embryonic limb morphogenesis GO:0030326 139 67 2,000 0,01313822 0,06368389 GO:0035113|embryonic appendage morphogenesis, ! myeloid cell differentiation GO:0030099 126 67 2,000 0,01313822 0,06355778 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 0,01323124 0,06388126 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 1,000 0,01323124 0,06375526 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 1,000 0,01323124 0,06362976 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 0,01323124 0,06350475 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 0,01323124 0,06338023 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 1,000 0,01323124 0,0632562 GO:0002708|positive regulation of lymphocyte mediated immunity, ! pallium development GO:0021543 56 24 1,000 0,01323124 0,06313265 ! platelet activation GO:0030168 41 24 1,000 0,01323124 0,06300958 ! regulation of amine transport GO:0051952 41 24 1,000 0,01323124 0,062887 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 0,01323124 0,06276489 ! positive regulation of T cell activation GO:0050870 124 68 2,000 0,01367176 0,0647289 ! viral reproduction GO:0016032 142 68 2,000 0,01367176 0,0646037 ! regulation of lipase activity GO:0060191 137 68 2,000 0,01367176 0,06447898 ! adaptive immune response GO:0002250 126 68 2,000 0,01367176 0,06435474 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 2,000 0,01367176 0,06423098 ! developmental maturation GO:0021700 128 69 2,000 0,01421748 0,06666663 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 0,01431309 0,06698637 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 0,01431309 0,06685829 ! regulation of transmembrane transport GO:0034762 39 25 1,000 0,01431309 0,06673069 ! leukocyte adhesion GO:0007159 55 25 1,000 0,01431309 0,06660359 ! vasculogenesis GO:0001570 49 25 1,000 0,01431309 0,06647697 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 0,01431309 0,06635082 ! immunoglobulin production GO:0002377 62 25 1,000 0,01431309 0,06622516 GO:0002440|production of molecular mediator of immune response, ! leukocyte homeostasis GO:0001776 50 25 1,000 0,01431309 0,06609997 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 0,01534562 0,07073461 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 0,01543184 0,07099807 ! initiation of viral infection GO:0019059 60 26 1,000 0,01543184 0,07086462 ! molting cycle process GO:0022404 52 26 1,000 0,01543184 0,07073166 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! protein amino acid alkylation GO:0008213 59 26 1,000 0,01543184 0,07059921 GO:0006479|protein amino acid methylation, ! spinal cord development GO:0021510 54 26 1,000 0,01543184 0,07046725 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 0,01543184 0,07033578 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 0,01543184 0,0702048 ! neural crest cell development GO:0014032 59 26 1,000 0,01543184 0,07007431 GO:0014033|neural crest cell differentiation, ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 0,01543184 0,0699443 ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,01543184 0,06981477 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 0,01543184 0,06968572 ! somatic diversification of immune receptors GO:0002200 63 26 1,000 0,01543184 0,06955715 ! neural tube closure GO:0001843 58 26 1,000 0,01543184 0,06942905 GO:0060606|tube closure, ! appendage morphogenesis GO:0035107 150 72 2,000 0,01592808 0,07152998 GO:0035108|limb morphogenesis, ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 0,01592808 0,07139873 ! appendage development GO:0048736 151 73 2,000 0,01652285 0,07392917 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 2,000 0,01652285 0,07379402 ! regulation of immune effector process GO:0002697 156 73 2,000 0,01652285 0,07365936 ! tube lumen formation GO:0035148 59 27 1,000 0,01658688 0,0738101 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 0,01658688 0,0736759 ! multicellular organismal catabolic process GO:0044243 38 27 1,000 0,01658688 0,07354219 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01658688 0,07340896 ! regulation of chromosome organization GO:0033044 49 27 1,000 0,01658688 0,07327621 ! regulation of caspase activity GO:0043281 136 74 2,000 0,01712994 0,07553873 ! reproductive structure development GO:0048608 131 75 2,000 0,01774938 0,07812925 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,01774938 0,07798873 ! leukocyte mediated immunity GO:0002443 136 75 2,000 0,01774938 0,07784872 ! neuron fate commitment GO:0048663 52 28 1,000 0,01777763 0,0778329 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01777763 0,07769366 ! circadian rhythm GO:0007623 56 28 1,000 0,01777763 0,07755493 ! dendrite development GO:0016358 67 28 1,000 0,01777763 0,07741668 ! positive regulation of innate immune response GO:0045089 49 28 1,000 0,01777763 0,07727893 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 0,01777763 0,07714167 ! glutathione metabolic process GO:0006749 42 28 1,000 0,01777763 0,07700489 ! lipid oxidation GO:0034440 48 28 1,000 0,01777763 0,0768686 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 1,000 0,01777763 0,07673279 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 2,000 0,01838117 0,0791979 ! catechol metabolic process GO:0009712 55 29 1,000 0,01900352 0,08173521 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01900352 0,08159156 ! respiratory gaseous exchange GO:0007585 61 29 1,000 0,01900352 0,08144842 ! primary neural tube formation GO:0014020 61 29 1,000 0,01900352 0,08130578 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 0,01900352 0,08116363 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01900352 0,08102199 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01900352 0,08088083 ! somitogenesis GO:0001756 52 29 1,000 0,01900352 0,08074017 ! neurotransmitter transport GO:0006836 142 77 2,000 0,01902534 0,08069255 ! cytosolic calcium ion homeostasis GO:0051480 149 77 2,000 0,01902534 0,08055271 ! regulation of catabolic process GO:0009894 173 77 2,000 0,01902534 0,08041334 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 0,01902534 0,08027446 ! phenol metabolic process GO:0018958 56 30 1,000 0,02026396 0,08535321 ! acute-phase response GO:0006953 50 30 1,000 0,02026396 0,0852063 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,02026396 0,0850599 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,02026396 0,084914 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 0,02026396 0,0847686 GO:0048871|multicellular organismal homeostasis, ! regulation of synaptic transmission GO:0050804 159 79 2,000 0,02035084 0,08498652 ! regulation of innate immune response GO:0045088 57 31 1,000 0,0215584 0,08987571 ! peptide transport GO:0015833 60 31 1,000 0,0215584 0,0897226 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 0,0215584 0,08957001 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 0,0215584 0,08941794 ! fatty acid catabolic process GO:0009062 54 31 1,000 0,0215584 0,08926639 ! eye morphogenesis GO:0048592 65 31 1,000 0,0215584 0,08911534 ! response to heat GO:0009408 54 31 1,000 0,0215584 0,08896481 ! positive regulation of immune effector process GO:0002699 78 31 1,000 0,0215584 0,08881478 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 2,000 0,02172595 0,08935438 ! regulation of peptidase activity GO:0052547 150 82 2,000 0,02243212 0,09210364 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 1,000 0,02288626 0,09381064 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,02288626 0,09365351 ! positive regulation of T cell proliferation GO:0042102 60 32 1,000 0,02288626 0,09349689 ! metanephros development GO:0001656 81 32 1,000 0,02288626 0,09334081 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,02288626 0,09318524 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,02288626 0,09303019 ! hindbrain development GO:0030902 65 32 1,000 0,02288626 0,09287565 ! gene silencing GO:0016458 71 32 1,000 0,02288626 0,09272163 ! response to metal ion GO:0010038 158 84 2,000 0,02388167 0,09659424 ! T cell activation GO:0042110 189 84 2,000 0,02388167 0,09643458 ! response to ionizing radiation GO:0010212 74 33 1,000 0,02424701 0,09774824 ! regulation of axonogenesis GO:0050770 86 33 1,000 0,02424701 0,09758721 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,02424701 0,0974267 ! negative regulation of transport GO:0051051 164 85 2,000 0,02462505 0,09878326 ! regulation of transmission of nerve impulse GO:0051969 167 85 2,000 0,02462505 0,09862132 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 0,02462505 0,09845991 ! cell fate specification GO:0001708 56 34 1,000 0,02564007 0,10235082 ! mitochondrion organization GO:0007005 159 87 2,000 0,02614899 0,10421206 ! chromatin assembly GO:0031497 128 88 2,000 0,02692953 0,10714796 ! DNA damage checkpoint GO:0000077 78 35 1,000 0,02706493 0,10751158 ! negative regulation of secretion GO:0051048 68 35 1,000 0,02706493 0,10733705 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,02706493 0,10716309 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,02706493 0,10698968 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,02706493 0,10681684 ! placenta development GO:0001890 53 35 1,000 0,02706493 0,10664456 ! cellular defense response GO:0006968 123 89 2,000 0,02772243 0,10905943 ! protein localization in nucleus GO:0034504 192 89 2,000 0,02772243 0,10888409 ! regulation of neurological system process GO:0031644 175 89 2,000 0,02772243 0,10870932 ! regulation of muscle development GO:0048634 82 36 1,000 0,02852104 0,11166168 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,02852104 0,11148303 ! protein targeting to membrane GO:0006612 75 36 1,000 0,02852104 0,11130494 ! response to inorganic substance GO:0010035 173 90 2,000 0,02852768 0,11115332 ! regulation of cell cycle process GO:0010564 161 90 2,000 0,02852768 0,11097632 ! defense response to bacterium GO:0042742 112 91 2,000 0,02934526 0,11397533 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,03000786 0,11636382 ! odontogenesis GO:0042476 74 37 1,000 0,03000786 0,11617941 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,03000786 0,11599558 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,03000786 0,11581234 ! protein-DNA complex assembly GO:0065004 134 92 2,000 0,03017516 0,11627431 ! regulation of cell adhesion GO:0030155 241 92 2,000 0,03017516 0,1160912 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,03152489 0,12109323 ! DNA integrity checkpoint GO:0031570 82 38 1,000 0,03152489 0,12090314 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,03152489 0,12071363 ! regulation of protein stability GO:0031647 77 38 1,000 0,03152489 0,12052472 ! glycogen metabolic process GO:0005977 63 38 1,000 0,03152489 0,1203364 ! neural tube formation GO:0001841 79 38 1,000 0,03152489 0,12014867 ! regulation of membrane potential GO:0042391 179 94 2,000 0,0318718 0,12128163 ! regulation of defense response GO:0031347 171 95 2,000 0,0327385 0,12438594 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 0,0327385 0,1241928 ! regulation of neuron projection development GO:0010975 102 39 1,000 0,03307159 0,12526185 ! negative regulation of binding GO:0051100 71 39 1,000 0,03307159 0,12506795 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,03307159 0,12487464 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 0,03307159 0,12468193 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,03307159 0,12448982 ! glucan metabolic process GO:0044042 64 39 1,000 0,03307159 0,1242983 GO:0006073|cellular glucan metabolic process, ! mismatch repair GO:0006298 58 40 1,000 0,03464746 0,13002111 ! forebrain development GO:0030900 210 98 2,000 0,03541182 0,13268569 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,03604521 0,13485214 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,03604521 0,13464595 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,03604521 0,13444038 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03604521 0,13423544 ! neuron fate determination GO:0048664 7 5 0,000 0,03604521 0,13403113 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03604521 0,13382743 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03604521 0,13362435 ! polyol transport GO:0015791 12 5 0,000 0,03604521 0,13342189 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03604521 0,13322004 ! response to superoxide GO:0000303 10 5 0,000 0,03604521 0,13301881 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03604521 0,13281817 GO:0045940|positive regulation of steroid metabolic process, ! tongue development GO:0043586 8 5 0,000 0,03604521 0,13261815 ! female meiosis GO:0007143 10 5 0,000 0,03604521 0,13241872 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03604521 0,13221989 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03604521 0,13202166 ! cobalt ion transport GO:0006824 11 5 0,000 0,03604521 0,13182403 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03604521 0,13162698 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03604521 0,13143052 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03604521 0,13123465 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,03604521 0,13103936 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03604521 0,13084465 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03604521 0,13065052 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03604521 0,13045696 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03604521 0,13026398 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! transposition GO:0032196 9 5 0,000 0,03604521 0,13007157 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,03604521 0,12987972 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,03604521 0,12968844 ! negative chemotaxis GO:0050919 16 5 0,000 0,03604521 0,12949772 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03604521 0,12930756 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03604521 0,12911796 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03604521 0,12892892 ! behavioral response to pain GO:0048266 10 5 0,000 0,03604521 0,12874042 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03604521 0,12855248 ! Notch receptor processing GO:0007220 11 5 0,000 0,03604521 0,12836509 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03604521 0,12817824 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03604521 0,12799193 ! micturition GO:0060073 9 5 0,000 0,03604521 0,12780617 ! copulation GO:0007620 9 5 0,000 0,03604521 0,12762094 ! glial cell fate commitment GO:0021781 14 5 0,000 0,03604521 0,12743625 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03604521 0,12725209 ! bioluminescence GO:0008218 9 5 0,000 0,03604521 0,12706847 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03604521 0,12688537 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03604521 0,12670281 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03604521 0,12652076 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03604521 0,12633924 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03604521 0,12615824 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03604521 0,12597775 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03604521 0,12579779 ! grooming behavior GO:0007625 6 5 0,000 0,03604521 0,12561833 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03604521 0,12543939 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03604521 0,12526095 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03604521 0,12508303 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03604521 0,1249056 ! lymph vessel development GO:0001945 10 5 0,000 0,03604521 0,12472868 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03604521 0,12455226 ! endochondral ossification GO:0001958 17 5 0,000 0,03604521 0,12437634 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! single strand break repair GO:0000012 8 5 0,000 0,03604521 0,12420092 ! parathyroid gland development GO:0060017 14 5 0,000 0,03604521 0,12402599 ! anagen GO:0042640 7 5 0,000 0,03604521 0,12385155 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03604521 0,1236776 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03604521 0,12350414 ! cytokine secretion GO:0050663 15 5 0,000 0,03604521 0,12333116 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03604521 0,12315867 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03604521 0,12298666 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,03604521 0,12281513 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,03604521 0,12264408 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03604521 0,1224735 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03604521 0,1223034 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03604521 0,12213377 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03604521 0,12196461 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,03604521 0,12179592 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03604521 0,12162769 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03604521 0,12145993 ! valine metabolic process GO:0006573 12 5 0,000 0,03604521 0,12129263 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03604521 0,12112579 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03604521 0,12095941 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03604521 0,12079348 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03604521 0,12062801 ! polyol catabolic process GO:0046174 9 5 0,000 0,03604521 0,120463 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03604521 0,12029843 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03604521 0,12013431 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03604521 0,11997064 ! muscle cell migration GO:0014812 8 5 0,000 0,03604521 0,11980741 ! mitochondrial fission GO:0000266 8 5 0,000 0,03604521 0,11964463 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03604521 0,11948229 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,03604521 0,11932039 ! nerve growth factor processing GO:0032455 9 5 0,000 0,03604521 0,11915893 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,03604521 0,1189979 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03604521 0,11883731 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03604521 0,11867716 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03604521 0,11851743 ! monocyte activation GO:0042117 10 5 0,000 0,03604521 0,11835813 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03604521 0,11819926 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03604521 0,11804082 ! response to food GO:0032094 6 5 0,000 0,03604521 0,1178828 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03604521 0,1177252 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03604521 0,11756802 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03604521 0,11741127 ! forebrain neuron development GO:0021884 13 5 0,000 0,03604521 0,11725493 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03604521 0,117099 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,03604521 0,11694349 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,03604521 0,11678839 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03604521 0,11663371 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03604521 0,11647943 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,03604521 0,11632556 ! lipid glycosylation GO:0030259 7 5 0,000 0,03604521 0,1161721 ! nucleobase transport GO:0015851 6 5 0,000 0,03604521 0,11601904 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03604521 0,11586638 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03604521 0,11571413 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03604521 0,11556227 ! basic amino acid transport GO:0015802 12 5 0,000 0,03604521 0,11541081 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,03604521 0,11525975 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03604521 0,11510908 ! actin nucleation GO:0045010 11 5 0,000 0,03604521 0,11495881 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03604521 0,11480893 ! depurination GO:0045007 5 5 0,000 0,03604521 0,11465944 ! depyrimidination GO:0045008 10 5 0,000 0,03604521 0,11451034 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03604521 0,11436162 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03604521 0,11421329 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,03604521 0,11406535 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,03604521 0,11391779 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03604521 0,11377061 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,03604521 0,11362381 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03604521 0,11347738 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03604521 0,11333134 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03604521 0,11318567 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03604521 0,11304037 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03604521 0,11289545 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03604521 0,1127509 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03604521 0,11260671 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03604521 0,1124629 ! response to arsenic GO:0046685 11 5 0,000 0,03604521 0,11231945 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,03604521 0,11217637 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03604521 0,11203365 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,03604521 0,1118913 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03604521 0,1117493 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03604521 0,11160767 ! response to mercury ion GO:0046689 8 5 0,000 0,03604521 0,11146639 ! response to cadmium ion GO:0046686 7 5 0,000 0,03604521 0,11132547 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03604521 0,11118491 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03604521 0,1110447 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03604521 0,11090485 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03604521 0,11076535 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03604521 0,11062619 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03604521 0,11048739 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03604521 0,11034893 ! decidualization GO:0046697 11 5 0,000 0,03604521 0,11021083 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03604521 0,11007306 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03604521 0,10993564 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03604521 0,10979857 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03604521 0,10966183 ! embryonic cleavage GO:0040016 6 5 0,000 0,03604521 0,10952543 ! peroxisome fission GO:0016559 5 5 0,000 0,03604521 0,10938938 ! histone demethylation GO:0016577 13 5 0,000 0,03604521 0,10925366 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03604521 0,10911828 ! mitotic recombination GO:0006312 9 5 0,000 0,03604521 0,10898323 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03604521 0,10884852 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03604521 0,10871414 ! metaphase plate congression GO:0051310 7 5 0,000 0,03604521 0,10858009 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03604521 0,10844637 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,03604521 0,10831298 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03604521 0,10817991 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03604521 0,10804718 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,03604521 0,10791477 ! muscle cell proliferation GO:0033002 12 5 0,000 0,03604521 0,10778268 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03604521 0,10765092 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,03604521 0,10751947 ! B cell homeostasis GO:0001782 13 5 0,000 0,03604521 0,10738835 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03604521 0,10725755 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03604521 0,10712707 ! metaphase GO:0051323 11 5 0,000 0,03604521 0,1069969 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03604521 0,10686705 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03604521 0,10673751 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03604521 0,10660829 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03604521 0,10647938 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03604521 0,10635078 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03604521 0,1062225 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03604521 0,10609452 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03604521 0,10596685 ! response to redox state GO:0051775 6 5 0,000 0,03604521 0,10583948 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03604521 0,10571242 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03604521 0,10558567 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03604521 0,10545922 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03604521 0,10533307 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03604521 0,10520723 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03604521 0,10508168 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03604521 0,10495644 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03604521 0,10483149 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03604521 0,10470684 ! striatum development GO:0021756 14 5 0,000 0,03604521 0,10458248 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,03604521 0,10445842 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03604521 0,10433466 ! glial cell migration GO:0008347 10 5 0,000 0,03604521 0,10421118 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03604521 0,104088 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03604521 0,10396511 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,03604521 0,10384251 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03604521 0,1037202 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03604521 0,10359818 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03604521 0,10347644 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03604521 0,10335499 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03604521 0,10323382 ! neuroprotection GO:0043526 8 5 0,000 0,03604521 0,10311294 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03604521 0,10299234 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,03604521 0,10287202 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03604521 0,10275198 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,03604521 0,10263223 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03604521 0,10251275 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03604521 0,10239355 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03604521 0,10227462 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,03604521 0,10215597 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03604521 0,1020376 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03604521 0,1019195 ! spindle assembly GO:0051225 6 5 0,000 0,03604521 0,10180168 ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03604521 0,10168412 ! protein palmitoylation GO:0018345 12 5 0,000 0,03604521 0,10156684 ! drug metabolic process GO:0017144 7 5 0,000 0,03604521 0,10144983 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03604521 0,10133308 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03604521 0,10121661 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03604521 0,1011004 ! regulation of hormone secretion GO:0046883 69 41 1,000 0,03625199 0,10156378 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 1,000 0,03625199 0,10144744 ! feeding behavior GO:0007631 69 41 1,000 0,03625199 0,10133137 ! mesenchymal cell development GO:0014031 94 41 1,000 0,03625199 0,10121556 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 95 41 1,000 0,03625199 0,10110002 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,03625199 0,10098474 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,03725474 0,10365983 GO:0060538|skeletal muscle organ development, ! ear morphogenesis GO:0042471 64 42 1,000 0,03788469 0,10529271 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,03788469 0,10517306 ! epithelial cell differentiation GO:0030855 83 43 1,000 0,03954505 0,10965784 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 1,000 0,03954505 0,10953351 ! glucose transport GO:0015758 66 43 1,000 0,03954505 0,10940946 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,03954505 0,10928569 ! segmentation GO:0035282 78 43 1,000 0,03954505 0,10916221 ! neuron migration GO:0001764 85 43 1,000 0,03954505 0,109039 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,04123259 0,11356394 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,04123259 0,11343605 ! hexose transport GO:0008645 68 44 1,000 0,04123259 0,11330845 GO:0015749|monosaccharide transport, ! biopolymer methylation GO:0043414 91 45 1,000 0,04294682 0,11788662 ! developmental growth GO:0048589 88 45 1,000 0,04294682 0,11775431 ! maintenance of location in cell GO:0051651 101 45 1,000 0,04294682 0,1176223 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04309741 0,11790256 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04309741 0,11777067 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,04309741 0,11763909 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,04309741 0,11750779 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04309741 0,11737679 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,04309741 0,11724608 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,04309741 0,11711566 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04309741 0,11698554 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,04309741 0,1168557 ! response to oxygen radical GO:0000305 11 6 0,000 0,04309741 0,11672614 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,04309741 0,11659688 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,04309741 0,1164679 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,04309741 0,11633921 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,04309741 0,1162108 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04309741 0,11608267 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,04309741 0,11595483 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04309741 0,11582726 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04309741 0,11569998 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,04309741 0,11557298 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04309741 0,11544625 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,04309741 0,1153198 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,04309741 0,11519363 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04309741 0,11506774 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,04309741 0,11494212 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,04309741 0,11481677 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04309741 0,1146917 ! malate metabolic process GO:0006108 13 6 0,000 0,04309741 0,1145669 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,04309741 0,11444237 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,04309741 0,11431811 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,04309741 0,11419412 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,04309741 0,1140704 ! protein refolding GO:0042026 15 6 0,000 0,04309741 0,11394695 ! opsonization GO:0008228 8 6 0,000 0,04309741 0,11382376 ! mating behavior GO:0007617 7 6 0,000 0,04309741 0,11370084 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,04309741 0,11357819 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,04309741 0,1134558 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,04309741 0,11333367 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04309741 0,11321181 ! response to interferon-gamma GO:0034341 16 6 0,000 0,04309741 0,11309021 ! toxin metabolic process GO:0009404 11 6 0,000 0,04309741 0,11296886 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04309741 0,11284778 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,04309741 0,11272696 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,04309741 0,1126064 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,04309741 0,11248609 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,04309741 0,11236604 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,04309741 0,11224625 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04309741 0,11212671 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,04309741 0,11200743 ! thymic T cell selection GO:0045061 16 6 0,000 0,04309741 0,1118884 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,04309741 0,11176962 ! protein lipoylation GO:0009249 10 6 0,000 0,04309741 0,11165109 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,04309741 0,11153282 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,04309741 0,1114148 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04309741 0,11129702 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,04309741 0,1111795 ! glutamate catabolic process GO:0006538 12 6 0,000 0,04309741 0,11106222 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,04309741 0,11094519 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04309741 0,1108284 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! response to pH GO:0009268 10 6 0,000 0,04309741 0,11071186 ! hyperosmotic response GO:0006972 10 6 0,000 0,04309741 0,11059557 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,04309741 0,11047952 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,04309741 0,11036371 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,04309741 0,11024815 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,04309741 0,11013283 ! urea metabolic process GO:0019627 7 6 0,000 0,04309741 0,11001774 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04309741 0,1099029 ! neutrophil activation GO:0042119 7 6 0,000 0,04309741 0,1097883 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04309741 0,10967394 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,04309741 0,10955981 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04309741 0,10944593 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,04309741 0,10933228 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,04309741 0,10921886 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04309741 0,10910568 ! neuron apoptosis GO:0051402 15 6 0,000 0,04309741 0,10899273 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04309741 0,10888002 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,04309741 0,10876754 ! carnitine transport GO:0015879 10 6 0,000 0,04309741 0,1086553 GO:0015838|betaine transport, ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,04309741 0,10854328 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,04309741 0,1084315 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,04309741 0,10831994 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,04309741 0,10820861 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04309741 0,10809752 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,04309741 0,10798665 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,04309741 0,10787601 ! establishment of spindle localization GO:0051293 16 6 0,000 0,04309741 0,10776559 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,04309741 0,1076554 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,04309741 0,10754544 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,04309741 0,1074357 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,04309741 0,10732618 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04309741 0,10721689 ! interaction with symbiont GO:0051702 14 6 0,000 0,04309741 0,10710781 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04309741 0,10699897 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,04309741 0,10689034 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,04309741 0,10678193 ! response to copper ion GO:0046688 10 6 0,000 0,04309741 0,10667374 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,04309741 0,10656577 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04309741 0,10645802 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,04309741 0,10635049 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,04309741 0,10624317 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,04309741 0,10613607 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04309741 0,10602919 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,04309741 0,10592252 ! hair follicle maturation GO:0048820 8 6 0,000 0,04309741 0,10581606 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04309741 0,10570982 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,04309741 0,10560379 ! response to pheromone GO:0019236 6 6 0,000 0,04309741 0,10549798 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,04309741 0,10539237 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,04309741 0,10528698 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,04309741 0,1051818 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,04309741 0,10507683 ! subpallium development GO:0021544 15 6 0,000 0,04309741 0,10497207 ! neural tube patterning GO:0021532 8 6 0,000 0,04309741 0,10486751 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,04309741 0,10476317 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,04309741 0,10465903 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04309741 0,1045551 ! G2 phase GO:0051319 16 6 0,000 0,04309741 0,10445137 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,04309741 0,10434785 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,04309741 0,10424454 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04309741 0,10414143 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,04309741 0,10403852 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04309741 0,10393582 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,04309741 0,10383332 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04309741 0,10373102 ! receptor internalization GO:0031623 11 6 0,000 0,04309741 0,10362892 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,04309741 0,10352702 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,04309741 0,10342533 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04309741 0,10332383 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 16 6 0,000 0,04309741 0,10322253 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,04309741 0,10312143 ! protein destabilization GO:0031648 9 6 0,000 0,04309741 0,10302053 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,04309741 0,10291983 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04309741 0,10281932 ! regulation of viral transcription GO:0046782 11 6 0,000 0,04309741 0,10271901 ! progesterone metabolic process GO:0042448 12 6 0,000 0,04309741 0,10261889 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,04309741 0,10251897 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,04309741 0,10241924 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,04309741 0,10231971 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,04309741 0,10222037 ! determination of adult lifespan GO:0008340 17 6 0,000 0,04309741 0,10212122 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04309741 0,10202227 ! neural plate development GO:0001840 9 6 0,000 0,04309741 0,10192351 ! catecholamine transport GO:0051937 9 6 0,000 0,04309741 0,10182493 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,04309741 0,10172655 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04309741 0,10162836 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,04309741 0,10153036 ! maternal placenta development GO:0001893 12 6 0,000 0,04309741 0,10143255 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,04309741 0,10133492 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04309741 0,10123748 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,04309741 0,10114023 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,04309741 0,10104317 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,04309741 0,10094629 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,04309741 0,1008496 GO:0055081|anion homeostasis, ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 1,000 0,04468728 0,10446988 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,04645348 0,10849507 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,04824496 0,11257157 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,04824496 0,11246415 ! regulation of inflammatory response GO:0050727 84 48 1,000 0,04824496 0,11235694 ! methylation GO:0032259 97 48 1,000 0,04824496 0,11224993 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,05006126 0,11636503 ! protein homooligomerization GO:0051260 84 49 1,000 0,05006126 0,11625442 ! tRNA transcription GO:0009304 17 7 0,000 0,05009822 0,11622977 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,05009822 0,1161195 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,05009822 0,11600943 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,05009822 0,11589958 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,05009822 0,11578993 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,05009822 0,11568048 ! sleep GO:0030431 16 7 0,000 0,05009822 0,11557125 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,05009822 0,11546222 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,05009822 0,1153534 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,05009822 0,11524478 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,05009822 0,11513636 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05009822 0,11502815 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,05009822 0,11492014 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,05009822 0,11481234 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05009822 0,11470474 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,05009822 0,11459733 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,05009822 0,11449013 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,05009822 0,11438313 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,05009822 0,11427633 ! glycolipid transport GO:0046836 11 7 0,000 0,05009822 0,11416973 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,05009822 0,11406333 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,05009822 0,11395713 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,05009822 0,11385112 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,05009822 0,11374531 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,05009822 0,1136397 ! pericardium development GO:0060039 16 7 0,000 0,05009822 0,11353428 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,05009822 0,11342906 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,05009822 0,11332403 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,05009822 0,1132192 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,05009822 0,11311456 ! lipoprotein transport GO:0042953 14 7 0,000 0,05009822 0,11301011 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,05009822 0,11290586 ! rhythmic behavior GO:0007622 17 7 0,000 0,05009822 0,1128018 ! neuron remodeling GO:0016322 16 7 0,000 0,05009822 0,11269793 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,05009822 0,11259425 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,05009822 0,11249077 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,05009822 0,11238747 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,05009822 0,11228436 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,05009822 0,11218144 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,05009822 0,11207871 ! mechanosensory behavior GO:0007638 16 7 0,000 0,05009822 0,11197617 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,05009822 0,11187381 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,05009822 0,11177165 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,05009822 0,11166966 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,05009822 0,11156787 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05009822 0,11146626 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05009822 0,11136483 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,05009822 0,11126359 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,05009822 0,11116254 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,05009822 0,11106166 ! adrenal gland development GO:0030325 17 7 0,000 0,05009822 0,11096097 ! cysteine metabolic process GO:0006534 13 7 0,000 0,05009822 0,11086046 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,05009822 0,11076014 ! ovulation GO:0030728 10 7 0,000 0,05009822 0,11065999 ! adenohypophysis development GO:0021984 11 7 0,000 0,05009822 0,11056003 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,05009822 0,11046025 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,05009822 0,11036064 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,05009822 0,11026122 ! microtubule nucleation GO:0007020 21 7 0,000 0,05009822 0,11016197 ! proline biosynthetic process GO:0006561 10 7 0,000 0,05009822 0,11006291 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,05009822 0,10996402 ! thyroid hormone generation GO:0006590 13 7 0,000 0,05009822 0,10986531 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,05009822 0,10976677 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,05009822 0,10966842 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05009822 0,10957024 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,05009822 0,10947223 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,05009822 0,1093744 ! galactose metabolic process GO:0006012 13 7 0,000 0,05009822 0,10927674 ! vesicle fusion GO:0006906 20 7 0,000 0,05009822 0,10917926 ! response to dietary excess GO:0002021 8 7 0,000 0,05009822 0,10908195 ! intracellular pH reduction GO:0051452 13 7 0,000 0,05009822 0,10898482 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,05009822 0,10888786 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,05009822 0,10879107 ! organ growth GO:0035265 15 7 0,000 0,05009822 0,10869445 ! nucleoside transport GO:0015858 11 7 0,000 0,05009822 0,10859801 ! nucleoside salvage GO:0043174 11 7 0,000 0,05009822 0,10850173 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,05009822 0,10840563 ! male sex determination GO:0030238 15 7 0,000 0,05009822 0,10830969 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,05009822 0,10821393 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! parturition GO:0007567 16 7 0,000 0,05009822 0,10811833 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,05009822 0,10802291 ! rRNA modification GO:0000154 14 7 0,000 0,05009822 0,10792765 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,05009822 0,10783256 ! spindle checkpoint GO:0031577 16 7 0,000 0,05009822 0,10773763 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,05009822 0,10764288 ! monocyte differentiation GO:0030224 16 7 0,000 0,05009822 0,10754829 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,05009822 0,10745387 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,05009822 0,10735961 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,05009822 0,10726552 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,05009822 0,10717159 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,05009822 0,10707782 ! fibrinolysis GO:0042730 11 7 0,000 0,05009822 0,10698422 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,05009822 0,10689079 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,05009822 0,10679752 ! eating behavior GO:0042755 8 7 0,000 0,05009822 0,10670441 ! B cell lineage commitment GO:0002326 21 7 0,000 0,05009822 0,10661146 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,05009822 0,10651867 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,05009822 0,10642605 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,05009822 0,10633358 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,05009822 0,10624128 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,05009822 0,10614914 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,05009822 0,10605715 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,05009822 0,10596533 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,05009822 0,10587366 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,05009822 0,10578215 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,05009822 0,10569081 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,05009822 0,10559961 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,05009822 0,10550858 ! histone ubiquitination GO:0016574 9 7 0,000 0,05009822 0,1054177 ! regulation of meiosis GO:0040020 12 7 0,000 0,05009822 0,10532698 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,05009822 0,10523642 ! T cell lineage commitment GO:0002360 16 7 0,000 0,05009822 0,10514601 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,05009822 0,10505575 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,05009822 0,10496565 ! membrane to membrane docking GO:0022614 14 7 0,000 0,05009822 0,10487571 ! transcription termination GO:0006353 14 7 0,000 0,05009822 0,10478592 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,05009822 0,10469628 ! anaphase GO:0051322 18 7 0,000 0,05009822 0,1046068 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,05009822 0,10451747 ! axonal fasciculation GO:0007413 19 7 0,000 0,05009822 0,10442829 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,05009822 0,10433926 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,05009822 0,10425039 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,05009822 0,10416166 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,05009822 0,10407309 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,05009822 0,10398467 ! thiamin metabolic process GO:0006772 7 7 0,000 0,05009822 0,10389639 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05009822 0,10380827 ! antibiotic transport GO:0042891 9 7 0,000 0,05009822 0,1037203 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,05009822 0,10363247 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,05009822 0,1035448 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,05009822 0,10345727 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,05009822 0,10336989 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,05009822 0,10328266 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,05009822 0,10319558 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,05009822 0,10310864 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,05009822 0,10302185 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,05009822 0,1029352 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,05009822 0,1028487 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,05009822 0,10276234 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,05009822 0,10267613 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,05009822 0,10259007 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,05009822 0,10250415 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,05009822 0,10241837 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,05009822 0,10233274 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,05009822 0,10224725 ! muscle adaptation GO:0043500 13 7 0,000 0,05009822 0,1021619 ! embryonic heart tube development GO:0035050 14 7 0,000 0,05009822 0,10207669 ! retina homeostasis GO:0001895 12 7 0,000 0,05009822 0,10199163 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,05009822 0,10190671 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,05009822 0,10182192 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,05009822 0,10173728 ! regulation of ossification GO:0030278 123 50 1,000 0,05190192 0,10531261 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,05190192 0,10522521 ! regulation of cell projection organization GO:0031344 135 51 1,000 0,05376649 0,10891503 ! peptide metabolic process GO:0006518 80 51 1,000 0,05376649 0,1088248 ! response to temperature stimulus GO:0009266 84 51 1,000 0,05376649 0,10873471 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,05376649 0,10864477 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,05565453 0,11236695 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,05565453 0,11227416 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,057048 0,11499033 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,057048 0,11489553 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,057048 0,11480088 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,057048 0,1147064 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,057048 0,11461207 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,057048 0,11451789 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,057048 0,11442387 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,057048 0,11433 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,057048 0,11423629 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 14 8 0,000 0,057048 0,11414273 ! response to zinc ion GO:0010043 12 8 0,000 0,057048 0,11404932 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,057048 0,11395607 ! oligopeptide transport GO:0006857 16 8 0,000 0,057048 0,11386297 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,057048 0,11377002 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,057048 0,11367722 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,057048 0,11358458 ! signal peptide processing GO:0006465 12 8 0,000 0,057048 0,11349208 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,057048 0,11339974 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,057048 0,11330754 ! succinate metabolic process GO:0006105 17 8 0,000 0,057048 0,1132155 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,057048 0,1131236 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,057048 0,11303185 ! estrogen metabolic process GO:0008210 17 8 0,000 0,057048 0,11294025 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,057048 0,11284881 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,057048 0,1127575 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,057048 0,11266635 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,057048 0,11257534 ! reflex GO:0060004 17 8 0,000 0,057048 0,11248448 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,057048 0,11239377 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,057048 0,1123032 ! pigment granule organization GO:0048753 17 8 0,000 0,057048 0,11221278 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,057048 0,11212251 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,057048 0,11203237 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,057048 0,11194239 ! histidine catabolic process GO:0006548 10 8 0,000 0,057048 0,11185255 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,057048 0,11176285 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,057048 0,1116733 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,057048 0,11158389 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,057048 0,11149462 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,057048 0,1114055 ! melanin metabolic process GO:0006582 17 8 0,000 0,057048 0,11131651 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,057048 0,11122767 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,057048 0,11113897 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,057048 0,11105042 ! macrophage activation GO:0042116 13 8 0,000 0,057048 0,110962 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,057048 0,11087373 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,057048 0,11078559 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,057048 0,1106976 ! purine salvage GO:0043101 12 8 0,000 0,057048 0,11060974 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,057048 0,11052203 ! osteoblast development GO:0002076 17 8 0,000 0,057048 0,11043445 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,057048 0,11034701 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,057048 0,11025971 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,057048 0,11017255 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,057048 0,11008552 ! response to UV-B GO:0010224 17 8 0,000 0,057048 0,10999864 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,057048 0,10991189 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,057048 0,10982528 ! intermediate filament organization GO:0045109 12 8 0,000 0,057048 0,1097388 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,057048 0,10965246 ! cellular extravasation GO:0045123 13 8 0,000 0,057048 0,10956625 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,057048 0,10948018 ! response to antibiotic GO:0046677 11 8 0,000 0,057048 0,10939425 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,057048 0,10930845 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,057048 0,10922279 ! DNA topological change GO:0006265 12 8 0,000 0,057048 0,10913725 ! response to tropane GO:0014073 15 8 0,000 0,057048 0,10905186 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,057048 0,10896659 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,057048 0,10888146 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,057048 0,10879647 ! mast cell activation GO:0045576 14 8 0,000 0,057048 0,1087116 ! multicellular organismal aging GO:0010259 20 8 0,000 0,057048 0,10862687 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,057048 0,10854227 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,057048 0,1084578 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,057048 0,10837346 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,057048 0,10828926 ! nucleosome disassembly GO:0006337 14 8 0,000 0,057048 0,10820518 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,057048 0,10812124 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,057048 0,10803742 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,057048 0,10795374 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,057048 0,10787018 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,057048 0,10778676 ! intracellular lipid transport GO:0032365 16 8 0,000 0,057048 0,10770346 ! response to tumor cell GO:0002347 16 8 0,000 0,057048 0,10762029 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,057048 0,10753725 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,057048 0,10745434 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,057048 0,10737155 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,057048 0,10728889 ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,057048 0,10720636 ! hormone catabolic process GO:0042447 17 8 0,000 0,057048 0,10712396 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,057048 0,10704169 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,057048 0,10695954 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,057048 0,10687751 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,057048 0,10679561 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,057048 0,10671384 GO:0010828|positive regulation of glucose transport, ! adult feeding behavior GO:0008343 10 8 0,000 0,057048 0,10663219 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,057048 0,10655067 ! ATP catabolic process GO:0006200 11 8 0,000 0,057048 0,10646927 ! blastocyst growth GO:0001832 19 8 0,000 0,057048 0,106388 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,057048 0,10630685 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,057048 0,10622582 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,057048 0,10614492 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,057048 0,10606414 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,057048 0,10598348 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,057048 0,10590294 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,057048 0,10582253 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,057048 0,10574224 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,057048 0,10566207 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,057048 0,10558203 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,057048 0,1055021 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,057048 0,1054223 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,057048 0,10534261 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,057048 0,10526305 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,057048 0,1051836 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,057048 0,10510428 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,057048 0,10502507 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,057048 0,10494599 ! positive regulation of growth GO:0045927 96 53 1,000 0,05756559 0,10581846 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 1,000 0,05756559 0,1057389 ! cartilage development GO:0051216 99 53 1,000 0,05756559 0,10565946 ! synapse organization GO:0050808 102 53 1,000 0,05756559 0,10558013 ! regulation of translational initiation GO:0006446 87 54 1,000 0,05949925 0,10904476 ! cell recognition GO:0008037 98 55 1,000 0,06145507 0,11254477 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,06145507 0,11246047 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,06343262 0,11599244 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,06343262 0,11590568 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,06343262 0,11581906 ! regulation of DNA replication GO:0006275 105 56 1,000 0,06343262 0,11573256 ! axon extension GO:0048675 16 9 0,000 0,06394714 0,11658422 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,06394714 0,11649728 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,06394714 0,11641047 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06394714 0,11632379 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,06394714 0,11623724 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,06394714 0,11615082 ! reproductive behavior GO:0019098 22 9 0,000 0,06394714 0,11606453 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06394714 0,11597836 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,06394714 0,11589232 ! UTP metabolic process GO:0046051 10 9 0,000 0,06394714 0,11580641 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,06394714 0,11572063 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,06394714 0,11563498 ! artery development GO:0060840 25 9 0,000 0,06394714 0,11554945 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,06394714 0,11546404 ! equilibrioception GO:0050957 20 9 0,000 0,06394714 0,11537877 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,06394714 0,11529362 ! chemosensory behavior GO:0007635 21 9 0,000 0,06394714 0,11520859 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,06394714 0,11512369 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06394714 0,11503892 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,06394714 0,11495427 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,06394714 0,11486974 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,06394714 0,11478534 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,06394714 0,11470107 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06394714 0,11461691 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06394714 0,11453288 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,06394714 0,11444898 ! protein targeting to ER GO:0045047 25 9 0,000 0,06394714 0,11436519 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,06394714 0,11428153 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,06394714 0,11419799 ! T cell selection GO:0045058 27 9 0,000 0,06394714 0,11411457 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,06394714 0,11403128 ! glycine catabolic process GO:0006546 15 9 0,000 0,06394714 0,1139481 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,06394714 0,11386505 ! endosome organization GO:0007032 20 9 0,000 0,06394714 0,11378212 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06394714 0,11369931 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,06394714 0,11361662 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06394714 0,11353405 ! mannose metabolic process GO:0006013 13 9 0,000 0,06394714 0,1134516 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,06394714 0,11336927 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,06394714 0,11328706 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,06394714 0,11320496 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,06394714 0,11312299 ! receptor clustering GO:0043113 20 9 0,000 0,06394714 0,11304114 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,06394714 0,1129594 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06394714 0,11287778 ! retinol metabolic process GO:0042572 20 9 0,000 0,06394714 0,11279628 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,06394714 0,1127149 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,06394714 0,11263363 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,06394714 0,11255249 ! macrophage differentiation GO:0030225 15 9 0,000 0,06394714 0,11247146 ! oligodendrocyte development GO:0014003 11 9 0,000 0,06394714 0,11239054 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06394714 0,11230974 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,06394714 0,11222906 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06394714 0,11214849 ! response to amine stimulus GO:0014075 13 9 0,000 0,06394714 0,11206804 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06394714 0,11198771 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,06394714 0,11190749 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06394714 0,11182738 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,06394714 0,11174739 ! renal water homeostasis GO:0003091 15 9 0,000 0,06394714 0,11166751 ! postreplication repair GO:0006301 25 9 0,000 0,06394714 0,11158775 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,06394714 0,1115081 ! icosanoid secretion GO:0032309 15 9 0,000 0,06394714 0,11142857 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06394714 0,11134915 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,06394714 0,11126984 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,06394714 0,11119064 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,06394714 0,11111156 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06394714 0,11103259 ! sterol catabolic process GO:0016127 14 9 0,000 0,06394714 0,11095373 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06394714 0,11087498 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,06394714 0,11079635 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,06394714 0,11071783 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,06394714 0,11063941 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,06394714 0,11056111 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,06394714 0,11048292 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,06394714 0,11040484 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,06394714 0,11032687 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06394714 0,11024901 ! purine base metabolic process GO:0006144 25 9 0,000 0,06394714 0,11017126 ! pigment granule transport GO:0051904 17 9 0,000 0,06394714 0,11009362 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,06394714 0,11001609 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,06394714 0,10993867 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06394714 0,10986136 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,06394714 0,10978415 ! mitochondrion localization GO:0051646 18 9 0,000 0,06394714 0,10970706 ! muscle fiber development GO:0048747 131 57 1,000 0,0654315 0,11217484 ! heart morphogenesis GO:0003007 105 57 1,000 0,0654315 0,11209617 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,06745127 0,11547544 ! aging GO:0007568 112 58 1,000 0,06745127 0,11539458 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,06745127 0,11531383 ! maintenance of location GO:0051235 124 58 1,000 0,06745127 0,11523319 ! regulation of developmental growth GO:0048638 16 10 0,000 0,07079598 0,12086274 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,07079598 0,12077834 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,07079598 0,12069406 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,07079598 0,12060989 ! associative learning GO:0008306 21 10 0,000 0,07079598 0,12052584 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,07079598 0,12044191 ! phosphate transport GO:0006817 24 10 0,000 0,07079598 0,12035809 ! cell volume homeostasis GO:0006884 17 10 0,000 0,07079598 0,1202744 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,07079598 0,12019081 ! CTP metabolic process GO:0046036 11 10 0,000 0,07079598 0,12010735 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,07079598 0,120024 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,07079598 0,11994076 ! GTP metabolic process GO:0046039 11 10 0,000 0,07079598 0,11985765 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,07079598 0,11977464 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,07079598 0,11969175 ! social behavior GO:0035176 29 10 0,000 0,07079598 0,11960898 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,07079598 0,11952632 GO:0048200|Golgi transport vesicle coating, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,07079598 0,11944377 ! androgen metabolic process GO:0008209 17 10 0,000 0,07079598 0,11936134 ! phospholipid efflux GO:0033700 19 10 0,000 0,07079598 0,11927902 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,07079598 0,11919682 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,07079598 0,11911473 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,07079598 0,11903275 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,07079598 0,11895088 ! pathogenesis GO:0009405 17 10 0,000 0,07079598 0,11886913 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,07079598 0,11878749 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,07079598 0,11870596 ! endoderm development GO:0007492 18 10 0,000 0,07079598 0,11862454 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,07079598 0,11854324 ! arginine catabolic process GO:0006527 17 10 0,000 0,07079598 0,11846204 ! proline metabolic process GO:0006560 13 10 0,000 0,07079598 0,11838096 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,07079598 0,11829999 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,07079598 0,11821913 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,07079598 0,11813838 ! V(D)J recombination GO:0033151 34 10 0,000 0,07079598 0,11805774 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,07079598 0,1179772 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,07079598 0,11789678 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,07079598 0,11781647 ! B cell proliferation GO:0042100 19 10 0,000 0,07079598 0,11773627 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,07079598 0,11765618 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,07079598 0,11757619 ! multicellular organism growth GO:0035264 19 10 0,000 0,07079598 0,11749632 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,07079598 0,11741655 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,07079598 0,11733689 ! ruffle organization GO:0031529 17 10 0,000 0,07079598 0,11725734 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,07079598 0,1171779 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,07079598 0,11709857 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,07079598 0,11701934 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,07079598 0,11694022 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,07079598 0,1168612 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,07079598 0,1167823 ! protein heterooligomerization GO:0051291 17 10 0,000 0,07079598 0,1167035 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,07079598 0,1166248 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,07079598 0,11654621 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,07079598 0,11646773 ! segment specification GO:0007379 15 10 0,000 0,07079598 0,11638936 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,07079598 0,11631108 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,07079598 0,11623292 ! blastoderm segmentation GO:0007350 19 10 0,000 0,07079598 0,11615486 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,07079598 0,1160769 ! response to dsRNA GO:0043331 23 10 0,000 0,07079598 0,11599905 ! DNA ligation GO:0006266 18 10 0,000 0,07079598 0,1159213 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,07079598 0,11584366 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,07079598 0,11576612 ! melanosome localization GO:0032400 16 10 0,000 0,07079598 0,11568868 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,07079598 0,11561135 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,07079598 0,11553412 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,07079598 0,115457 ! induction of an organ GO:0001759 17 10 0,000 0,07079598 0,11537997 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,07079598 0,11530305 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,07079598 0,11522624 ! protein sumoylation GO:0016925 17 10 0,000 0,07079598 0,11514952 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,07079598 0,11507291 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,07079598 0,1149964 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07079598 0,11491999 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,07079598 0,11484368 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,07079598 0,11476747 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,07079598 0,11469137 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! midbrain development GO:0030901 14 10 0,000 0,07079598 0,11461536 ! musculoskeletal movement GO:0050881 16 10 0,000 0,07079598 0,11453946 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,07079598 0,11446365 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,07079598 0,11438795 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,07079598 0,11431235 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,07079598 0,11423684 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,07079598 0,11416144 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,07079598 0,11408614 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,07079598 0,11401093 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,07079598 0,11393582 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,07079598 0,11386082 ! blastocyst formation GO:0001825 18 10 0,000 0,07079598 0,11378591 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,07079598 0,1137111 ! cerebellar cortex development GO:0021695 16 10 0,000 0,07079598 0,11363639 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,07079598 0,11356177 GO:0042267|natural killer cell mediated cytotoxicity, ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,07079598 0,11348726 ! adult behavior GO:0030534 104 60 1,000 0,07155189 0,11462379 ! camera-type eye development GO:0043010 126 61 1,000 0,07363194 0,11787865 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,07573127 0,12116011 ! respiratory burst GO:0045730 17 11 0,000 0,07759491 0,12406044 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,07759491 0,12397931 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,07759491 0,12389827 ! thyroid gland development GO:0030878 26 11 0,000 0,07759491 0,12381735 ! synapsis GO:0007129 14 11 0,000 0,07759491 0,12373653 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,07759491 0,12365581 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,07759491 0,1235752 ! response to pain GO:0048265 27 11 0,000 0,07759491 0,1234947 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,07759491 0,1234143 ! bone resorption GO:0045453 16 11 0,000 0,07759491 0,123334 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,07759491 0,12325381 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07759491 0,12317372 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07759491 0,12309374 ! histidine metabolic process GO:0006547 22 11 0,000 0,07759491 0,12301386 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,07759491 0,12293409 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,07759491 0,12285441 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,07759491 0,12277484 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,07759491 0,12269538 ! UV protection GO:0009650 20 11 0,000 0,07759491 0,12261601 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,07759491 0,12253675 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07759491 0,1224576 ! macroautophagy GO:0016236 19 11 0,000 0,07759491 0,12237854 ! temperature homeostasis GO:0001659 18 11 0,000 0,07759491 0,12229959 ! behavioral fear response GO:0001662 27 11 0,000 0,07759491 0,12222073 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,07759491 0,12214198 ! negative regulation of ossification GO:0030279 27 11 0,000 0,07759491 0,12206333 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,07759491 0,12198479 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,07759491 0,12190634 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,07759491 0,12182799 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,07759491 0,12174975 ! regulation of organ growth GO:0046620 14 11 0,000 0,07759491 0,1216716 ! pigment granule localization GO:0051875 20 11 0,000 0,07759491 0,12159356 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,07759491 0,12151561 ! vasoconstriction GO:0042310 20 11 0,000 0,07759491 0,12143777 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,07759491 0,12136003 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,07759491 0,12128238 ! embryonic axis specification GO:0000578 19 11 0,000 0,07759491 0,12120483 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,07759491 0,12112739 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07759491 0,12105004 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,07759491 0,12097279 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,07759491 0,12089564 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,07759491 0,12081858 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,07759491 0,12074163 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,07759491 0,12066477 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,07759491 0,12058801 ! prophase GO:0051324 17 11 0,000 0,07759491 0,12051135 ! neuroblast proliferation GO:0007405 25 11 0,000 0,07759491 0,12043479 ! nucleosome positioning GO:0016584 15 11 0,000 0,07759491 0,12035832 ! regulation of isotype switching GO:0045191 24 11 0,000 0,07759491 0,12028195 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,07759491 0,12020568 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,07759491 0,12012951 ! apical protein localization GO:0045176 18 11 0,000 0,07759491 0,12005343 ! acid secretion GO:0046717 20 11 0,000 0,07759491 0,11997744 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07759491 0,11990156 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,07759491 0,11982576 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,07759491 0,11975007 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,07759491 0,11967447 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,07759491 0,11959896 ! cholesterol efflux GO:0033344 21 11 0,000 0,07759491 0,11952356 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07759491 0,11944824 ! oocyte development GO:0048599 20 11 0,000 0,07759491 0,11937302 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,07759491 0,1192979 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,07759491 0,11922287 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,07759491 0,11914793 ! activation of innate immune response GO:0002218 16 11 0,000 0,07759491 0,11907309 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,07759491 0,11899834 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,07759491 0,11892369 ! lysogeny GO:0030069 22 11 0,000 0,07759491 0,11884913 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07759491 0,11877466 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,07759491 0,11870029 ! sequestering of metal ion GO:0051238 15 11 0,000 0,07759491 0,11862601 ! regulation of embryonic development GO:0045995 35 11 0,000 0,07759491 0,11855182 ! nucleus localization GO:0051647 22 11 0,000 0,07759491 0,11847772 ! regulation of mitosis GO:0007088 112 63 1,000 0,0778495 0,11879221 GO:0051783|regulation of nuclear division, ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,07998625 0,12197653 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,08214113 0,12518451 ! ear development GO:0043583 114 66 1,000 0,08431376 0,12841554 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,08434428 0,12838197 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,08434428 0,12830203 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,08434428 0,12822219 ! virus-host interaction GO:0019048 30 12 0,000 0,08434428 0,12814245 ! mating GO:0007618 17 12 0,000 0,08434428 0,12806281 ! protein complex disassembly GO:0043241 28 12 0,000 0,08434428 0,12798327 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,08434428 0,12790383 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,08434428 0,12782448 ! hippocampus development GO:0021766 29 12 0,000 0,08434428 0,12774524 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,08434428 0,12766609 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,08434428 0,12758704 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08434428 0,12750809 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,08434428 0,12742923 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,08434428 0,12735047 ! drug transport GO:0015893 16 12 0,000 0,08434428 0,12727181 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,08434428 0,12719325 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,08434428 0,12711479 ! polyamine metabolic process GO:0006595 18 12 0,000 0,08434428 0,12703642 ! mitotic spindle organization GO:0007052 23 12 0,000 0,08434428 0,12695814 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,08434428 0,12687997 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,08434428 0,12680189 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 21 12 0,000 0,08434428 0,1267239 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,08434428 0,12664602 ! entry into host cell GO:0030260 34 12 0,000 0,08434428 0,12656822 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08434428 0,12649053 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,08434428 0,12641292 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08434428 0,12633542 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,08434428 0,12625801 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,08434428 0,12618069 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,08434428 0,12610347 ! snRNA metabolic process GO:0016073 30 12 0,000 0,08434428 0,12602634 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,08434428 0,12594931 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,08434428 0,12587237 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08434428 0,12579552 ! fucose catabolic process GO:0019317 25 12 0,000 0,08434428 0,12571877 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,08434428 0,12564211 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,08434428 0,12556555 ! zymogen activation GO:0031638 18 12 0,000 0,08434428 0,12548908 ! T cell homeostasis GO:0043029 28 12 0,000 0,08434428 0,1254127 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,08434428 0,12533642 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,08434428 0,12526022 ! oocyte differentiation GO:0009994 21 12 0,000 0,08434428 0,12518412 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,08434428 0,12510812 ! defense response to fungus GO:0050832 15 12 0,000 0,08434428 0,1250322 ! developmental induction GO:0031128 22 12 0,000 0,08434428 0,12495638 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,08434428 0,12488065 ! response to cold GO:0009409 17 12 0,000 0,08434428 0,12480501 ! establishment of cell polarity GO:0030010 21 12 0,000 0,08434428 0,12472946 ! regulation of synapse organization GO:0050807 18 12 0,000 0,08434428 0,124654 ! activation of MAPK activity GO:0000187 124 67 1,000 0,08650378 0,12776828 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,08871081 0,13094895 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,08871081 0,13086987 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,08871081 0,13079089 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,09104445 0,13415053 ! cGMP metabolic process GO:0046068 18 13 0,000 0,09104445 0,13406967 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,09104445 0,13398891 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,09104445 0,13390824 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,09104445 0,13382767 ! peroxisomal transport GO:0043574 28 13 0,000 0,09104445 0,1337472 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,09104445 0,13366682 ! cartilage condensation GO:0001502 22 13 0,000 0,09104445 0,13358654 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,09104445 0,13350635 ! organelle fusion GO:0048284 36 13 0,000 0,09104445 0,13342627 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,09104445 0,13334627 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,09104445 0,13326638 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,09104445 0,13318658 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,09104445 0,13310687 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,09104445 0,13302726 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,09104445 0,13294775 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,09104445 0,13286833 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,09104445 0,13278901 ! methionine metabolic process GO:0006555 31 13 0,000 0,09104445 0,13270978 ! plasma membrane organization GO:0007009 27 13 0,000 0,09104445 0,13263064 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,09104445 0,1325516 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,09104445 0,13247265 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,09104445 0,1323938 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,09104445 0,13231504 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,09104445 0,13223638 ! cytokine metabolic process GO:0042107 24 13 0,000 0,09104445 0,13215781 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,09104445 0,13207933 ! asymmetric protein localization GO:0008105 24 13 0,000 0,09104445 0,13200094 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,09104445 0,13192265 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,09104445 0,13184445 ! L-glutamate transport GO:0015813 30 13 0,000 0,09104445 0,13176634 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,09104445 0,13168833 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,09104445 0,13161041 ! protein homotetramerization GO:0051289 24 13 0,000 0,09104445 0,13153258 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,09104445 0,13145484 ! regulation of DNA repair GO:0006282 23 13 0,000 0,09104445 0,13137719 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,09104445 0,13129964 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,09104445 0,13122217 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,09104445 0,1311448 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,09104445 0,13106752 ! regulation of epidermis development GO:0045682 19 13 0,000 0,09104445 0,13099033 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,09104445 0,13091323 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,09104445 0,13083623 ! spleen development GO:0048536 24 13 0,000 0,09104445 0,13075931 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,09104445 0,13068248 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,09104445 0,13060575 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,09104445 0,1305291 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,09104445 0,13045254 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,09104445 0,13037608 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,09104445 0,1302997 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,09104445 0,13022341 ! insulin secretion GO:0030073 24 13 0,000 0,09104445 0,13014721 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,09104445 0,1300711 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,09104445 0,12999508 ! acrosome reaction GO:0007340 19 13 0,000 0,09104445 0,12991915 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,09104445 0,12984331 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,09104445 0,12976755 ! rRNA transcription GO:0009303 28 14 0,000 0,09769578 0,13916664 ! regulation of S phase GO:0033261 26 14 0,000 0,09769578 0,13908554 ! water transport GO:0006833 21 14 0,000 0,09769578 0,13900454 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,09769578 0,13892362 ! non-recombinational repair GO:0000726 29 14 0,000 0,09769578 0,13884281 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,09769578 0,13876209 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,09769578 0,13868146 ! RNA polyadenylation GO:0043631 32 14 0,000 0,09769578 0,13860092 ! lipid localization GO:0010876 32 14 0,000 0,09769578 0,13852048 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,09769578 0,13844013 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,09769578 0,13835988 ! regulated secretory pathway GO:0045055 24 14 0,000 0,09769578 0,13827971 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,09769578 0,13819965 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,09769578 0,13811967 ! arginine metabolic process GO:0006525 21 14 0,000 0,09769578 0,13803978 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,09769578 0,13795999 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,09769578 0,13788029 ! regulation of heart rate GO:0002027 25 14 0,000 0,09769578 0,13780069 ! fear response GO:0042596 34 14 0,000 0,09769578 0,13772117 ! organic alcohol transport GO:0015850 29 14 0,000 0,09769578 0,13764175 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,09769578 0,13756241 ! neutral amino acid transport GO:0015804 28 14 0,000 0,09769578 0,13748317 ! bone mineralization GO:0030282 18 14 0,000 0,09769578 0,13740402 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,09769578 0,13732496 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,09769578 0,137246 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,09769578 0,13716712 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,09769578 0,13708833 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,09769578 0,13700964 ! regulation of cellular pH GO:0030641 27 14 0,000 0,09769578 0,13693103 ! ribosome assembly GO:0042255 18 14 0,000 0,09769578 0,13685252 ! cerebellum development GO:0021549 23 14 0,000 0,09769578 0,13677409 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,09769578 0,13669575 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,09769578 0,13661751 ! response to gamma radiation GO:0010332 30 14 0,000 0,09769578 0,13653935 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,09769578 0,13646129 ! NADP metabolic process GO:0006739 24 14 0,000 0,09769578 0,13638331 ! oxygen transport GO:0015671 22 14 0,000 0,09769578 0,13630542 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,09769578 0,13622762 ! male genitalia development GO:0030539 26 14 0,000 0,09769578 0,13614991 ! regulation of axon extension GO:0030516 43 14 0,000 0,09769578 0,13607228 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,09769578 0,13599475 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,09769578 0,13591731 ! carbohydrate transport GO:0008643 114 72 1,000 0,09770187 0,13584841 ! actin filament organization GO:0007015 167 72 1,000 0,09770187 0,13577114 ! acute inflammatory response GO:0002526 118 74 1,000 0,10229023 0,14206653 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,10429862 0,1447736 ! lactation GO:0007595 30 15 0,000 0,10429862 0,14469139 ! reproductive cellular process GO:0048610 22 15 0,000 0,10429862 0,14460927 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10429862 0,14452725 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,10429862 0,14444532 ! superoxide anion generation GO:0042554 22 15 0,000 0,10429862 0,14436348 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,10429862 0,14428173 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,10429862 0,14420008 ! copper ion transport GO:0006825 22 15 0,000 0,10429862 0,14411852 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,10429862 0,14403705 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,10429862 0,14395567 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,10429862 0,14387439 ! sulfate transport GO:0008272 27 15 0,000 0,10429862 0,14379319 ! response to cAMP GO:0051591 25 15 0,000 0,10429862 0,14371209 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,10429862 0,14363108 ! response to hexose stimulus GO:0009746 25 15 0,000 0,10429862 0,14355016 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,10429862 0,14346933 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,10429862 0,1433886 ! vesicle coating GO:0006901 38 15 0,000 0,10429862 0,14330795 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,10429862 0,1432274 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,10429862 0,14314693 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,10429862 0,14306656 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,10429862 0,14298627 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,10429862 0,14290608 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,10429862 0,14282597 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,10429862 0,14274596 ! regulation of vasodilation GO:0042312 27 15 0,000 0,10429862 0,14266604 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,10429862 0,1425862 ! water homeostasis GO:0030104 28 15 0,000 0,10429862 0,14250645 ! cofactor transport GO:0051181 30 15 0,000 0,10429862 0,1424268 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10429862 0,14234723 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,10429862 0,14226775 ! intestinal absorption GO:0050892 31 15 0,000 0,10429862 0,14218836 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,10429862 0,14210906 ! heme biosynthetic process GO:0006783 33 15 0,000 0,10429862 0,14202984 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,10429862 0,14195072 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,10429862 0,14187168 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,10429862 0,14179273 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,10429862 0,14171387 ! actin filament polymerization GO:0030041 27 15 0,000 0,10429862 0,1416351 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,10429862 0,14155641 ! eye development GO:0001654 155 75 1,000 0,10460642 0,14189532 ! axon guidance GO:0007411 162 75 1,000 0,10460642 0,14181658 ! rhythmic process GO:0048511 142 75 1,000 0,10460642 0,14173792 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,10693683 0,14481523 ! learning or memory GO:0007611 161 76 1,000 0,10693683 0,144735 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,10928113 0,14782603 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,10928113 0,14774422 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,11085334 0,14978689 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,11085334 0,14970409 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,11085334 0,14962138 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,11085334 0,14953876 ! bone remodeling GO:0046849 28 16 0,000 0,11085334 0,14945624 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11085334 0,1493738 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,11085334 0,14929146 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,11085334 0,1492092 ! startle response GO:0001964 28 16 0,000 0,11085334 0,14912704 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,11085334 0,14904496 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,11085334 0,14896298 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,11085334 0,14888109 ! protein polyubiquitination GO:0000209 41 16 0,000 0,11085334 0,14879929 ! glutamate metabolic process GO:0006536 25 16 0,000 0,11085334 0,14871757 ! response to osmotic stress GO:0006970 27 16 0,000 0,11085334 0,14863595 ! lysosomal transport GO:0007041 31 16 0,000 0,11085334 0,14855442 ! fructose metabolic process GO:0006000 25 16 0,000 0,11085334 0,14847297 ! L-amino acid transport GO:0015807 33 16 0,000 0,11085334 0,14839162 ! stem cell development GO:0048864 46 16 0,000 0,11085334 0,14831035 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,11085334 0,14822917 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,11085334 0,14814809 ! intermediate filament-based process GO:0045103 36 16 0,000 0,11085334 0,14806709 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,11085334 0,14798617 ! negative regulation of immune response GO:0050777 38 16 0,000 0,11085334 0,14790535 ! axon cargo transport GO:0008088 46 16 0,000 0,11085334 0,14782462 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,11085334 0,14774397 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,11085334 0,14766341 ! neuron recognition GO:0008038 40 16 0,000 0,11085334 0,14758294 ! mRNA splice site selection GO:0006376 44 16 0,000 0,11085334 0,14750256 ! tissue regeneration GO:0042246 27 16 0,000 0,11085334 0,14742226 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,11085334 0,14734206 ! biomineral formation GO:0031214 22 16 0,000 0,11085334 0,14726194 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,11085334 0,1471819 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,11085334 0,14710196 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,11085334 0,1470221 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,11085334 0,14694232 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,11085334 0,14686264 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,11085334 0,14678304 ! peptide hormone processing GO:0016486 27 16 0,000 0,11085334 0,14670352 ! blood coagulation GO:0007596 151 79 1,000 0,11401013 0,15079954 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,11401013 0,15071794 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,11401013 0,15063642 ! protein oligomerization GO:0051259 149 79 1,000 0,11401013 0,150555 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 1,000 0,11639418 0,15362019 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,11639418 0,15353725 ! metencephalon development GO:0022037 32 17 0,000 0,11736026 0,15472808 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,11736026 0,15464462 ! signal complex assembly GO:0007172 47 17 0,000 0,11736026 0,15456125 ! filopodium assembly GO:0046847 42 17 0,000 0,11736026 0,15447798 ! endothelial cell migration GO:0043542 31 17 0,000 0,11736026 0,15439479 ! gene silencing by RNA GO:0031047 38 17 0,000 0,11736026 0,15431169 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,11736026 0,15422868 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,11736026 0,15414577 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,11736026 0,15406294 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,11736026 0,1539802 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,11736026 0,15389754 ! myoblast differentiation GO:0045445 50 17 0,000 0,11736026 0,15381498 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,11736026 0,15373251 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,11736026 0,15365012 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,11736026 0,15356782 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,11736026 0,15348561 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,11736026 0,15340349 ! NAD metabolic process GO:0019674 33 17 0,000 0,11736026 0,15332146 ! membrane budding GO:0006900 42 17 0,000 0,11736026 0,15323951 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,11736026 0,15315765 ! regulation of protein binding GO:0043393 33 17 0,000 0,11736026 0,15307588 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,11736026 0,1529942 ! genitalia development GO:0048806 32 17 0,000 0,11736026 0,1529126 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,11736026 0,15283109 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,11736026 0,15274967 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,11736026 0,15266833 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,11736026 0,15258708 ! steroid catabolic process GO:0006706 34 17 0,000 0,11736026 0,15250592 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,11736026 0,15242484 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,11736026 0,15234385 ! gas transport GO:0015669 26 17 0,000 0,11736026 0,15226294 ! organic cation transport GO:0015695 32 17 0,000 0,11736026 0,15218213 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,11736026 0,15210139 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,11736026 0,15202074 ! meiosis GO:0007126 143 81 1,000 0,11879084 0,15379228 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,11879084 0,15371082 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,12119981 0,15674491 ! protein import into nucleus GO:0006606 174 82 1,000 0,12119981 0,15666198 ! meiotic cell cycle GO:0051321 144 82 1,000 0,12119981 0,15657913 ! exocytosis GO:0006887 153 83 1,000 0,12362078 0,15962239 ! response to drug GO:0042493 149 83 1,000 0,12362078 0,15953807 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,12362078 0,15945383 ! nuclear import GO:0051170 177 83 1,000 0,12362078 0,15936969 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,12381975 0,15954202 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,12381975 0,15945791 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,12381975 0,1593739 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,12381975 0,15928997 ! adult walking behavior GO:0007628 36 18 0,000 0,12381975 0,15920614 ! patterning of blood vessels GO:0001569 43 18 0,000 0,12381975 0,15912239 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,12381975 0,15903873 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,12381975 0,15895516 ! centrosome cycle GO:0007098 26 18 0,000 0,12381975 0,15887167 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,12381975 0,15878827 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,12381975 0,15870496 ! glutamine metabolic process GO:0006541 29 18 0,000 0,12381975 0,15862174 ! response to retinoic acid GO:0032526 31 18 0,000 0,12381975 0,15853861 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,12381975 0,15845556 ! DNA integration GO:0015074 32 18 0,000 0,12381975 0,1583726 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,12381975 0,15828972 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,12381975 0,15820694 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,12381975 0,15812423 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,12381975 0,15804162 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,12381975 0,15795909 GO:0046466|membrane lipid catabolic process, ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,12381975 0,15787665 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,12381975 0,15779429 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,12381975 0,15771202 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,12381975 0,15762984 ! detection of bacterium GO:0016045 22 18 0,000 0,12381975 0,15754774 ! microspike assembly GO:0030035 46 18 0,000 0,12381975 0,15746573 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,12381975 0,1573838 ! regulation of ligase activity GO:0051340 147 84 1,000 0,12605344 0,16013965 ! hemostasis GO:0007599 165 85 1,000 0,1284975 0,16315976 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,1284975 0,163075 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,13023215 0,16519063 ! negative regulation of defense response GO:0031348 27 19 0,000 0,13023215 0,1651049 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,13023215 0,16501927 ! neuron maturation GO:0042551 46 19 0,000 0,13023215 0,16493372 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,13023215 0,16484826 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,13023215 0,16476289 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,13023215 0,16467761 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,13023215 0,16459242 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,13023215 0,16450732 ! inositol metabolic process GO:0006020 33 19 0,000 0,13023215 0,1644223 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,13023215 0,16433737 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,13023215 0,16425253 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,13023215 0,16416778 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,13023215 0,16408311 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,13023215 0,16399853 ! response to vitamin A GO:0033189 32 19 0,000 0,13023215 0,16391404 ! heme metabolic process GO:0042168 40 19 0,000 0,13023215 0,16382963 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,13023215 0,16374532 ! response to fungus GO:0009620 26 19 0,000 0,13023215 0,16366109 ! peptide cross-linking GO:0018149 39 19 0,000 0,13023215 0,16357694 ! protein export from nucleus GO:0006611 40 19 0,000 0,13023215 0,16349288 ! heart process GO:0003015 32 19 0,000 0,13023215 0,16340891 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,13023215 0,16332503 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,13023215 0,16324123 ! visual learning GO:0008542 38 19 0,000 0,13023215 0,16315751 ! cellular pigmentation GO:0033059 37 19 0,000 0,13023215 0,16307389 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,13023215 0,16299034 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,13023215 0,16290689 ! vitamin transport GO:0051180 31 19 0,000 0,13023215 0,16282352 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,13023215 0,16274023 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,13023215 0,16265703 ! cilium assembly GO:0042384 38 19 0,000 0,13023215 0,16257391 ! nucleosome assembly GO:0006334 126 87 1,000 0,13341862 0,16646665 ! protein secretion GO:0009306 45 20 0,000 0,1365978 0,17034631 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,1365978 0,1702594 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,1365978 0,17017258 ! positive regulation of ossification GO:0045778 50 20 0,000 0,1365978 0,17008584 ! skin development GO:0043588 42 20 0,000 0,1365978 0,1699992 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,1365978 0,16991264 ! response to vitamin GO:0033273 36 20 0,000 0,1365978 0,16982617 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,1365978 0,16973979 ! bile acid metabolic process GO:0008206 34 20 0,000 0,1365978 0,1696535 ! retinoid metabolic process GO:0001523 34 20 0,000 0,1365978 0,16956729 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,1365978 0,16948117 ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,1365978 0,16939514 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,1365978 0,1693092 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,1365978 0,16922334 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,1365978 0,16913757 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,1365978 0,16905189 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,1365978 0,16896629 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,1365978 0,16888078 ! cell-cell junction organization GO:0045216 43 20 0,000 0,1365978 0,16879536 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,1365978 0,16871002 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,1365978 0,16862477 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,1365978 0,16853961 ! regulation of glucose import GO:0046324 30 20 0,000 0,1365978 0,16845453 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,1365978 0,16836954 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,1365978 0,16828463 ! negative regulation of translation GO:0017148 32 20 0,000 0,1365978 0,16819981 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,1365978 0,16811508 ! response to unfolded protein GO:0006986 139 90 1,000 0,14087853 0,17329619 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,14291704 0,17571531 ! cAMP metabolic process GO:0046058 41 21 0,000 0,14291704 0,17562692 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,14291704 0,17553862 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,14291704 0,17545041 ! ovarian follicle development GO:0001541 39 21 0,000 0,14291704 0,17536229 ! smooth muscle contraction GO:0006939 48 21 0,000 0,14291704 0,17527426 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,14291704 0,17518631 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,14291704 0,17509846 ! plasma membrane fusion GO:0045026 33 21 0,000 0,14291704 0,17501069 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,14291704 0,17492301 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,14291704 0,17483541 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,14291704 0,17474791 ! collagen fibril organization GO:0030199 62 21 0,000 0,14291704 0,17466049 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,14291704 0,17457316 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,14291704 0,17448592 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,14291704 0,17439876 ! actin filament-based movement GO:0030048 47 21 0,000 0,14291704 0,17431169 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,14291704 0,17422471 ! ossification GO:0001503 205 91 1,000 0,14338489 0,17470788 ! bone development GO:0060348 206 92 1,000 0,14590066 0,17768461 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,1491902 0,18160023 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,1491902 0,18150979 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,1491902 0,18141944 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,1491902 0,18132918 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 59 22 0,000 0,1491902 0,18123902 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,1491902 0,18114894 ! cellular response to starvation GO:0009267 37 22 0,000 0,1491902 0,18105895 ! vacuolar transport GO:0007034 41 22 0,000 0,1491902 0,18096905 ! central nervous system neuron development GO:0021954 47 22 0,000 0,1491902 0,18087924 ! fucose metabolic process GO:0006004 44 22 0,000 0,1491902 0,18078951 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,1491902 0,18069988 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,1491902 0,18061034 ! cell aging GO:0007569 48 22 0,000 0,1491902 0,18052088 ! stem cell differentiation GO:0048863 57 22 0,000 0,1491902 0,18043152 ! cytolysis GO:0019835 27 22 0,000 0,1491902 0,18034224 ! renal system process GO:0003014 42 22 0,000 0,1491902 0,18025305 ! vasodilation GO:0042311 40 22 0,000 0,1491902 0,18016395 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,1491902 0,18007493 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,1491902 0,17998601 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,1491902 0,17989717 ! sarcomere organization GO:0045214 32 22 0,000 0,1491902 0,17980842 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,1491902 0,17971975 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,1491902 0,17963118 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,1491902 0,17954269 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,1491902 0,17945429 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,1491902 0,17936597 ! protein stabilization GO:0050821 41 22 0,000 0,1491902 0,17927775 ! female pregnancy GO:0007565 166 94 1,000 0,15095935 0,1813145 ! nucleosome organization GO:0034728 143 95 1,000 0,15350173 0,18427751 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,15541762 0,18648588 ! gluconeogenesis GO:0006094 38 23 0,000 0,15541762 0,18639433 ! glycerol metabolic process GO:0006071 40 23 0,000 0,15541762 0,18630287 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,15541762 0,1862115 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,15541762 0,18612022 ! axis specification GO:0009798 43 23 0,000 0,15541762 0,18602903 ! visual behavior GO:0007632 46 23 0,000 0,15541762 0,18593793 ! response to ethanol GO:0045471 47 23 0,000 0,15541762 0,18584692 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,15541762 0,185756 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,15541762 0,18566516 ! peroxisome organization GO:0007031 43 23 0,000 0,15541762 0,18557442 ! lysosome organization GO:0007040 47 23 0,000 0,15541762 0,18548376 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,15541762 0,18539319 ! vesicle targeting GO:0006903 49 23 0,000 0,15541762 0,18530271 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,15541762 0,18521232 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,15541762 0,18512202 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,15541762 0,1850318 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,15541762 0,18494167 ! DNA modification GO:0006304 36 23 0,000 0,15541762 0,18485163 ! fatty acid transport GO:0015908 47 23 0,000 0,15541762 0,18476168 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,15541762 0,18467182 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,15541762 0,18458204 ! cell-cell recognition GO:0009988 28 23 0,000 0,15541762 0,18449235 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,15541762 0,18440275 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,15541762 0,18431323 GO:0006099|tricarboxylic acid cycle, ! sex differentiation GO:0007548 171 96 1,000 0,15605246 0,18497631 ! response to protein stimulus GO:0051789 158 96 1,000 0,15605246 0,1848866 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,15861128 0,18782713 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,16159964 0,19127322 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,16159964 0,19118059 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,16159964 0,19108806 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,16159964 0,19099561 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,16159964 0,19090325 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,16159964 0,19081098 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,16159964 0,1907188 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,16159964 0,19062671 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,16159964 0,19053471 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,16159964 0,1904428 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,16159964 0,19035098 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,16159964 0,19025924 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,16159964 0,19016759 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,16159964 0,19007603 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,16159964 0,18998456 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,16159964 0,18989318 ! membrane depolarization GO:0051899 45 24 0,000 0,16159964 0,18980189 ! oogenesis GO:0048477 44 24 0,000 0,16159964 0,18971068 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,16159964 0,18961956 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,16159964 0,18952853 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,16159964 0,18943758 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,16159964 0,18934673 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,16159964 0,18925596 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,16159964 0,18916527 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,16159964 0,18907468 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,16159964 0,18898417 ! positive regulation of immune response GO:0050778 175 100 1,000 0,16633376 0,19442745 ! hormone metabolic process GO:0042445 171 100 1,000 0,16633376 0,19433447 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,16773658 0,19587976 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,16773658 0,19578618 ! phototransduction GO:0007602 37 25 0,000 0,16773658 0,19569268 ! keratinization GO:0031424 37 25 0,000 0,16773658 0,19559927 ! vacuole organization GO:0007033 49 25 0,000 0,16773658 0,19550595 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,16773658 0,19541272 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,16773658 0,19531957 ! receptor metabolic process GO:0043112 53 25 0,000 0,16773658 0,19522652 ! chromosome condensation GO:0030261 48 25 0,000 0,16773658 0,19513356 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,16773658 0,19504068 ! interaction with host GO:0051701 66 25 0,000 0,16773658 0,19494789 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,16773658 0,19485519 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,16773658 0,19476258 ! liver development GO:0001889 55 25 0,000 0,16773658 0,19467006 ! protein tetramerization GO:0051262 57 25 0,000 0,16773658 0,19457762 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,17382877 0,20154897 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,17382877 0,20145336 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,17382877 0,20135784 ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,17382877 0,20126241 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,17382877 0,20116707 GO:0051297|centrosome organization, ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,17382877 0,20107182 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,17382877 0,20097666 ! digestive system process GO:0022600 49 26 0,000 0,17382877 0,20088159 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,17382877 0,20078661 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,17382877 0,20069172 ! osteoblast differentiation GO:0001649 63 26 0,000 0,17382877 0,20059692 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,17382877 0,20050221 ! negative regulation of cell development GO:0010721 83 26 0,000 0,17382877 0,20040759 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,17382877 0,20031306 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,17382877 0,20021862 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,17382877 0,20012426 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,17382877 0,20003 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,17382877 0,19993582 ! blastocyst development GO:0001824 50 26 0,000 0,17382877 0,19984174 ! telomere organization GO:0032200 46 26 0,000 0,17382877 0,19974774 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,17382877 0,19965383 ! alditol metabolic process GO:0019400 44 26 0,000 0,17382877 0,19956 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,17382877 0,19946627 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,17382877 0,19937262 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,17987654 0,20621228 ! embryonic pattern specification GO:0009880 49 27 0,000 0,17987654 0,20611556 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,17987654 0,20601893 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,17987654 0,20592239 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,17987654 0,20582594 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,17987654 0,20572958 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,17987654 0,20563331 ! iron ion transport GO:0006826 65 27 0,000 0,17987654 0,20553713 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,17987654 0,20544104 ! superoxide metabolic process GO:0006801 41 27 0,000 0,17987654 0,20534504 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,17987654 0,20524913 ! response to starvation GO:0042594 47 27 0,000 0,17987654 0,2051533 ! response to toxin GO:0009636 49 27 0,000 0,17987654 0,20505757 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,17987654 0,20496193 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,17987654 0,20486638 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,1858802 0,21160546 ! vesicle docking GO:0048278 55 28 0,000 0,1858802 0,21150691 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,1858802 0,21140844 ! fat cell differentiation GO:0045444 57 28 0,000 0,1858802 0,21131006 ! sperm motility GO:0030317 37 28 0,000 0,1858802 0,21121178 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,1858802 0,21111359 ! base-excision repair GO:0006284 41 28 0,000 0,1858802 0,21101549 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,1858802 0,21091748 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,1858802 0,21081956 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,1858802 0,21072173 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,1858802 0,21062399 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,1858802 0,21052634 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,1858802 0,21042879 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,1858802 0,21033132 ! translational initiation GO:0006413 66 29 0,000 0,19184008 0,21697468 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,19184008 0,21687428 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! autophagy GO:0006914 47 29 0,000 0,19184008 0,21677397 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,19184008 0,21667375 ! synaptogenesis GO:0007416 46 29 0,000 0,19184008 0,21657362 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,19184008 0,21647359 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,19184008 0,21637365 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,19184008 0,2162738 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,19184008 0,21617404 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,1977565 0,22273819 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,1977565 0,22263554 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,1977565 0,22253299 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,1977565 0,22243054 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,1977565 0,22232818 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,1977565 0,22222591 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,1977565 0,22212374 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,1977565 0,22202166 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,1977565 0,22191967 ! myofibril assembly GO:0030239 50 30 0,000 0,1977565 0,22181778 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,1977565 0,22171598 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,1977565 0,22161428 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,1977565 0,22151267 ! cell fate determination GO:0001709 64 30 0,000 0,1977565 0,22141115 ! phospholipid transport GO:0015914 65 30 0,000 0,1977565 0,22130972 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,1977565 0,22120839 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,1977565 0,22110715 GO:0046496|nicotinamide nucleotide metabolic process, ! regulation of coagulation GO:0050818 52 30 0,000 0,1977565 0,221006 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,20362977 0,22746572 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,20362977 0,22736176 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,20362977 0,22725789 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,20362977 0,22715412 ! ovulation cycle process GO:0022602 55 31 0,000 0,20362977 0,22705044 ! male gonad development GO:0008584 56 31 0,000 0,20362977 0,22694686 ! detection of light stimulus GO:0009583 44 31 0,000 0,20362977 0,22684338 ! natural killer cell activation GO:0030101 50 31 0,000 0,20362977 0,22673998 ! cofactor catabolic process GO:0051187 54 31 0,000 0,20362977 0,22663669 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,2094602 0,23301971 ! spindle organization GO:0007051 50 32 0,000 0,2094602 0,23291364 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,2094602 0,23280768 ! muscle cell development GO:0055001 52 32 0,000 0,2094602 0,23270181 ! mesoderm formation GO:0001707 73 32 0,000 0,2094602 0,23259604 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,2094602 0,23249036 ! ovulation cycle GO:0042698 57 32 0,000 0,2094602 0,23238478 ! BMP signaling pathway GO:0030509 71 32 0,000 0,2094602 0,23227929 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,2094602 0,2321739 ! regulation of pH GO:0006885 56 33 0,000 0,21524812 0,23848125 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,21524812 0,23837314 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,21524812 0,23826513 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,21524812 0,23815722 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,21524812 0,23804941 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,21524812 0,2379417 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,21524812 0,23783408 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,21524812 0,23772656 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,21524812 0,23761914 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,21524812 0,23751181 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,22099381 0,24374171 ! post-embryonic development GO:0009791 76 34 0,000 0,22099381 0,24363172 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,22099381 0,24352183 ! cholesterol transport GO:0030301 62 34 0,000 0,22099381 0,24341203 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,22099381 0,24330234 ! spliceosome assembly GO:0000245 75 34 0,000 0,22099381 0,24319274 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,22099381 0,24308325 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,22099381 0,24297385 ! formation of primary germ layer GO:0001704 76 34 0,000 0,22099381 0,24286455 ! adult locomotory behavior GO:0008344 62 34 0,000 0,22099381 0,24275535 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,22099381 0,24264624 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,22669761 0,24879706 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,22669761 0,24868534 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,22669761 0,24857372 ! membrane docking GO:0022406 69 35 0,000 0,22669761 0,2484622 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,22669761 0,24835078 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,22669761 0,24823947 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,22669761 0,24812825 ! ceramide metabolic process GO:0006672 72 35 0,000 0,22669761 0,24801713 ! sterol transport GO:0015918 63 35 0,000 0,22669761 0,24790611 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,22669761 0,24779519 ! vesicle localization GO:0051648 70 35 0,000 0,22669761 0,24768437 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,23235979 0,25375725 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,23235979 0,25364387 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,23235979 0,25353058 ! positive regulation of cell development GO:0010720 85 36 0,000 0,23235979 0,2534174 ! regulation of proteolysis GO:0030162 77 36 0,000 0,23235979 0,25330432 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,23235979 0,25319134 ! aerobic respiration GO:0009060 56 36 0,000 0,23235979 0,25307845 ! cytokine production GO:0001816 68 36 0,000 0,23235979 0,25296567 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,23235979 0,252853 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,23235979 0,25274042 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,23798068 0,25873912 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,23798068 0,25862402 ! sister chromatid segregation GO:0000819 65 37 0,000 0,23798068 0,25850903 ! actomyosin structure organization GO:0031032 68 37 0,000 0,23798068 0,25839413 ! female gonad development GO:0008585 71 37 0,000 0,23798068 0,25827934 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,23798068 0,25816465 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,24356057 0,26410052 ! meiosis I GO:0007127 74 38 0,000 0,24356057 0,26398335 ! organic anion transport GO:0015711 82 38 0,000 0,24356057 0,26386628 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,24356057 0,26374932 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,24356057 0,26363246 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,24356057 0,26351571 ! spermatid development GO:0007286 69 38 0,000 0,24356057 0,26339905 ! pigment metabolic process GO:0042440 87 38 0,000 0,24356057 0,26328251 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,24909975 0,26915112 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,24909975 0,26903213 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,24909975 0,26891325 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,25459853 0,274728 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,25459853 0,27460671 ! learning GO:0007612 82 40 0,000 0,25459853 0,27448553 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,25459853 0,27436445 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,25459853 0,27424347 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,25459853 0,27412261 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,25459853 0,27400185 ! RNA export from nucleus GO:0006405 61 41 0,000 0,26005719 0,27975329 ! mRNA catabolic process GO:0006402 79 41 0,000 0,26005719 0,27963016 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,26005719 0,27950713 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,26005719 0,27938422 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,26005719 0,27926141 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,26005719 0,27913871 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,26005719 0,27901612 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,26005719 0,27889364 ! RNA modification GO:0009451 64 41 0,000 0,26005719 0,27877127 ! organic ether metabolic process GO:0018904 59 42 0,000 0,26547603 0,28445524 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,26547603 0,28433053 ! T cell differentiation GO:0030217 93 42 0,000 0,26547603 0,28420594 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,26547603 0,28408145 ! cytokinesis GO:0000910 84 42 0,000 0,26547603 0,28395707 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,26547603 0,2838328 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,27085534 0,28945739 ! regulation of tube size GO:0035150 76 43 0,000 0,27085534 0,28933082 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,27085534 0,28920437 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,27085534 0,28907802 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,27085534 0,28895179 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,27085534 0,28882566 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,27085534 0,28869965 ! ion transmembrane transport GO:0034220 79 43 0,000 0,27085534 0,28857374 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,2761954 0,29413486 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,2761954 0,2940067 ! striated muscle contraction GO:0006941 85 44 0,000 0,2761954 0,29387865 ! phagocytosis GO:0006909 105 44 0,000 0,2761954 0,29375071 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,2761954 0,29362288 ! double-strand break repair GO:0006302 85 44 0,000 0,2761954 0,29349516 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,28149651 0,29899825 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,28149651 0,29886831 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,28149651 0,29873848 ! B cell differentiation GO:0030183 124 45 0,000 0,28149651 0,29860876 ! female gamete generation GO:0007292 71 45 0,000 0,28149651 0,29847915 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,28149651 0,29834966 ! polyol metabolic process GO:0019751 77 45 0,000 0,28149651 0,29822028 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,28675894 0,30366367 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,28675894 0,3035321 ! glycolysis GO:0006096 71 46 0,000 0,28675894 0,30340064 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,28675894 0,3032693 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,28675894 0,30313807 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,29716888 0,31400674 ! mitochondrial transport GO:0006839 94 48 0,000 0,29716888 0,31387098 ! endosome transport GO:0016197 127 48 0,000 0,29716888 0,31373534 ! male sex differentiation GO:0046661 93 48 0,000 0,29716888 0,31359982 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,29716888 0,31346441 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,30231696 0,31875716 ! JNK cascade GO:0007254 106 49 0,000 0,30231696 0,31861964 ! regulation of ion transport GO:0043269 86 50 0,000 0,30742747 0,32386602 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,30742747 0,32372643 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,30742747 0,32358695 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,30742747 0,32344759 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,30742747 0,32330835 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,30742747 0,32316924 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,31250069 0,32836094 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,31753689 0,33350929 ! Notch signaling pathway GO:0007219 111 52 0,000 0,31753689 0,33336597 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,31753689 0,33322277 ! excretion GO:0007588 87 52 0,000 0,31753689 0,3330797 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,31753689 0,33293675 ! amino acid activation GO:0043038 98 52 0,000 0,31753689 0,33279392 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,32253634 0,33788862 ! inner ear development GO:0048839 89 53 0,000 0,32253634 0,33774379 ! vesicle organization GO:0016050 127 53 0,000 0,32253634 0,33759909 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,32253634 0,3374545 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,3274993 0,34250034 ! neuromuscular process GO:0050905 107 54 0,000 0,3274993 0,34235378 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,3274993 0,34220735 ! membrane fusion GO:0006944 122 54 0,000 0,3274993 0,34206105 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,3274993 0,34191487 ! RNA catabolic process GO:0006401 103 55 0,000 0,33242605 0,34691022 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,33242605 0,3467621 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,33242605 0,3466141 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,33242605 0,34646622 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,33242605 0,34631848 ! glucose catabolic process GO:0006007 88 56 0,000 0,33731683 0,35126386 ! chloride transport GO:0006821 102 57 0,000 0,34217193 0,35616788 ! regulation of actin filament length GO:0030832 118 58 0,000 0,34699159 0,36103086 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,34699159 0,36087716 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,34699159 0,3607236 ! gastrulation GO:0007369 122 58 0,000 0,34699159 0,36057016 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,34699159 0,36041686 ! nuclear export GO:0051168 110 59 0,000 0,35177607 0,36523117 ! establishment of organelle localization GO:0051656 122 59 0,000 0,35177607 0,36507602 ! regulation of endocytosis GO:0030100 104 60 0,000 0,35652564 0,36984804 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,35652564 0,36969106 ! regulation of cellular component size GO:0032535 125 61 0,000 0,36124053 0,37442114 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,36124053 0,37426235 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,36124053 0,3741037 ! regulation of heart contraction GO:0008016 123 61 0,000 0,36124053 0,37394518 ! proton transport GO:0015992 117 61 0,000 0,36124053 0,37378679 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,36124053 0,37362854 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,36592101 0,37830937 ! tRNA processing GO:0008033 102 62 0,000 0,36592101 0,37814934 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,37056733 0,382789 ! mesoderm development GO:0007498 128 63 0,000 0,37056733 0,38262721 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,37056733 0,38246556 ! hydrogen transport GO:0006818 121 64 0,000 0,37517972 0,38706253 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,37517972 0,38689914 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,37975845 0,39145565 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,37975845 0,39129055 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,37975845 0,39112559 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,37975845 0,39096077 ! gonad development GO:0008406 115 66 0,000 0,38430376 0,39547349 ! chromosome segregation GO:0007059 127 67 0,000 0,38881588 0,39994829 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,38881588 0,39977996 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,38881588 0,39961177 ! secondary metabolic process GO:0019748 125 67 0,000 0,38881588 0,39944373 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,39329506 0,4038755 ! hexose catabolic process GO:0019320 113 68 0,000 0,39329506 0,40370581 ! extracellular matrix organization GO:0030198 146 68 0,000 0,39329506 0,40353625 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,39329506 0,40336684 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,39774153 0,40775601 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,39774153 0,40758497 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,39774153 0,40741408 ! single fertilization GO:0007338 83 69 0,000 0,39774153 0,40724332 ! cell redox homeostasis GO:0045454 114 70 0,000 0,40215555 0,41159028 ! germ cell development GO:0007281 133 70 0,000 0,40215555 0,41141793 ! activation of immune response GO:0002253 120 70 0,000 0,40215555 0,41124571 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,40215555 0,41107364 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,40653734 0,4153788 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,40653734 0,41520515 ! B cell activation GO:0042113 179 72 0,000 0,41088713 0,41947232 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,41088713 0,4192971 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,41088713 0,41912203 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,41088713 0,41894711 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,41088713 0,41877233 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,41520517 0,42299676 ! amino acid transport GO:0006865 148 74 0,000 0,41949168 0,42718556 ! organelle localization GO:0051640 155 74 0,000 0,41949168 0,42700757 ! transition metal ion transport GO:0000041 143 75 0,000 0,42374688 0,43115936 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,42797102 0,4352761 ! regulation of blood pressure GO:0008217 134 76 0,000 0,42797102 0,43509496 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,42797102 0,43491397 ! amine catabolic process GO:0009310 136 77 0,000 0,4321643 0,43899268 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,4321643 0,43881022 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,4321643 0,43862792 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,43632697 0,44266893 ! antigen processing and presentation GO:0019882 117 78 0,000 0,43632697 0,44248518 ! fertilization GO:0009566 99 78 0,000 0,43632697 0,44230157 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,44045924 0,44630523 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,44045924 0,4461202 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,44456133 0,4500884 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,44456133 0,44990196 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,45668871 0,46198366 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,45668871 0,46179244 ! inorganic anion transport GO:0015698 156 83 0,000 0,45668871 0,46160138 ! response to nutrient GO:0007584 135 84 0,000 0,46067227 0,46543522 ! digestion GO:0007586 130 84 0,000 0,46067227 0,46524281 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,46462673 0,46904261 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,46462673 0,46884887 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,46855231 0,4726149 ! regulation of lyase activity GO:0051339 169 86 0,000 0,46855231 0,47241985 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,47244921 0,47615241 ! alcohol catabolic process GO:0046164 142 87 0,000 0,47244921 0,47595605 ! cellular respiration GO:0045333 143 88 0,000 0,47631765 0,47965541 ! sensory perception of smell GO:0007608 117 88 0,000 0,47631765 0,47945778 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,48015783 0,48312421 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,48396996 0,48675941 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,48775424 0,49036362 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,49524006 0,49768468 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,49524006 0,49748004 ! vitamin metabolic process GO:0006766 153 93 0,000 0,49524006 0,49727557 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,498942 0,5007869 ! sterol metabolic process GO:0016125 166 94 0,000 0,498942 0,50058124 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,498942 0,50037574 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,5026169 0,50385436 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,5026169 0,5036477 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,5026169 0,5034412 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,5026169 0,50323487 ! leukocyte differentiation GO:0002521 232 98 0,000 0,51348127 0,51390198 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,51348127 0,51369154 ! mRNA transport GO:0051028 185 100 0,000 0,52059252 0,52059252