pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6461-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 3,000 7,756E-09 1,895E-05 ! regulation of intracellular protein transport GO:0033157 86 42 4,000 4,054E-08 4,952E-05 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 4,000 6,487E-08 5,283E-05 ! regulation of intracellular transport GO:0032386 108 57 4,000 1,944E-07 1,187E-04 ! activation of MAPKKK activity GO:0000185 12 6 2,000 2,185E-07 1,068E-04 ! regulation of protein export from nucleus GO:0046825 10 7 2,000 3,818E-07 1,554E-04 ! male meiosis GO:0007140 9 8 2,000 6,098E-07 2,128E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 6,098E-07 1,862E-04 ! dendrite morphogenesis GO:0048813 14 8 2,000 6,098E-07 1,655E-04 ! axon extension GO:0048675 16 9 2,000 9,133E-07 2,231E-04 ! central nervous system neuron axonogenesis GO:0021955 23 10 2,000 1,303E-06 2,893E-04 GO:0021952|central nervous system projection neuron axonogenesis, ! androgen receptor signaling pathway GO:0030521 81 37 3,000 1,485E-06 3,023E-04 ! regulation of protein transport GO:0051223 165 87 4,000 1,627E-06 3,058E-04 GO:0070201|regulation of establishment of protein localization, ! regulation of protein localization GO:0032880 188 97 4,000 2,788E-06 4,866E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 3,304E-06 5,381E-04 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 4,899E-06 7,48E-04 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 2,000 6,02E-06 8,65E-04 ! activation of MAPKK activity GO:0000186 43 17 2,000 7,298E-06 9,904E-04 ! response to UV GO:0009411 120 55 3,000 7,435E-06 9,559E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 3,000 8,581E-06 1,048E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 1,217E-05 1,416E-03 ! negative regulation of intracellular transport GO:0032387 44 21 2,000 1,418E-05 1,575E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 1,542E-05 1,638E-03 ! central nervous system neuron development GO:0021954 47 22 2,000 1,639E-05 1,669E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 1,639E-05 1,602E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 1,84E-05 1,729E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 1,948E-05 1,763E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 2,061E-05 1,798E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 2,148E-05 1,809E-03 ! central nervous system neuron differentiation GO:0021953 51 24 2,000 2,148E-05 1,749E-03 ! negative regulation of transferase activity GO:0051348 155 74 3,000 2,428E-05 1,914E-03 ! learning or memory GO:0007611 161 76 3,000 2,698E-05 2,06E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 2,75E-05 2,036E-03 ! dendrite development GO:0016358 67 28 2,000 3,453E-05 2,481E-03 ! meiosis GO:0007126 143 81 3,000 3,469E-05 2,422E-03 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 144 82 3,000 3,641E-05 2,471E-03 ! cell adhesion mediated by integrin GO:0033627 10 5 1,000 4,981E-05 3,289E-03 ! microvillus organization GO:0032528 8 5 1,000 4,981E-05 3,202E-03 GO:0030033|microvillus assembly, ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 4,981E-05 3,12E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 4,981E-05 3,042E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 4,981E-05 2,968E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 4,981E-05 2,897E-03 ! spindle organization GO:0007051 50 32 2,000 5,195E-05 2,951E-03 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 5,195E-05 2,884E-03 ! negative regulation of protein transport GO:0051224 74 33 2,000 5,705E-05 3,097E-03 ! forebrain development GO:0030900 210 98 3,000 7,317E-05 3,886E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 1,000 7,46E-05 3,878E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 7,46E-05 3,797E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! response to UV-C GO:0010225 14 6 1,000 7,46E-05 3,719E-03 ! cytoplasmic microtubule organization GO:0031122 18 6 1,000 7,46E-05 3,645E-03 ! mammary gland development GO:0030879 93 40 2,000 1,021E-04 4,893E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 1,043E-04 4,9E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,043E-04 4,807E-03 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 1,043E-04 4,718E-03 ! wound healing, spreading of epidermal cells GO:0035313 16 7 1,000 1,043E-04 4,632E-03 ! centrosome duplication GO:0051298 14 7 1,000 1,043E-04 4,55E-03 ! mesenchymal cell development GO:0014031 94 41 2,000 1,1E-04 4,716E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! neuron migration GO:0001764 85 43 2,000 1,27E-04 5,348E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,388E-04 5,749E-03 ! ER overload response GO:0006983 13 8 1,000 1,388E-04 5,653E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 1,388E-04 5,561E-03 ! blastocyst growth GO:0001832 19 8 1,000 1,388E-04 5,471E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 1,455E-04 5,643E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 1,554E-04 5,933E-03 ! glycolysis GO:0006096 71 46 2,000 1,554E-04 5,841E-03 ! positive regulation of protein transport GO:0051222 80 46 2,000 1,554E-04 5,753E-03 ! positive regulation of cell cycle GO:0045787 96 48 2,000 1,765E-04 6,436E-03 ! endosome transport GO:0016197 127 48 2,000 1,765E-04 6,341E-03 ! cell proliferation in forebrain GO:0021846 18 9 1,000 1,783E-04 6,311E-03 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 1,783E-04 6,221E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,783E-04 6,134E-03 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 1,877E-04 6,369E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 2,225E-04 7,446E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 2,225E-04 7,345E-03 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 2,225E-04 7,247E-03 ! multicellular organism growth GO:0035264 19 10 1,000 2,225E-04 7,152E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 2,225E-04 7,059E-03 ! motor axon guidance GO:0008045 22 10 1,000 2,225E-04 6,969E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 2,371E-04 7,333E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,715E-04 8,292E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,715E-04 8,19E-03 ! oocyte development GO:0048599 20 11 1,000 2,715E-04 8,09E-03 ! nucleus localization GO:0051647 22 11 1,000 2,715E-04 7,993E-03 ! glucose catabolic process GO:0006007 88 56 2,000 2,793E-04 8,122E-03 ! regulation of B cell proliferation GO:0030888 22 12 1,000 3,254E-04 9,352E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 3,254E-04 9,243E-03 ! histone acetylation GO:0016573 27 12 1,000 3,254E-04 9,137E-03 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,254E-04 9,033E-03 ! oocyte differentiation GO:0009994 21 12 1,000 3,254E-04 8,931E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 3,254E-04 8,832E-03 GO:0042130|negative regulation of T cell proliferation, ! localization within membrane GO:0051668 26 12 1,000 3,254E-04 8,735E-03 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 3,84E-04 0,01019619 GO:0000725|recombinational repair, ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 3,84E-04 0,01008656 ! response to X-ray GO:0010165 28 13 1,000 3,84E-04 9,979E-03 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,84E-04 9,874E-03 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 3,84E-04 9,771E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 4,143E-04 0,01043502 ! regulation of S phase GO:0033261 26 14 1,000 4,473E-04 0,01115095 ! bone mineralization GO:0030282 18 14 1,000 4,473E-04 0,01103832 ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 4,473E-04 0,01092793 ! response to gamma radiation GO:0010332 30 14 1,000 4,473E-04 0,01081974 ! hexose catabolic process GO:0019320 113 68 2,000 4,952E-04 0,01185962 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 5,154E-04 0,01222402 ! regulation of mRNA processing GO:0050684 26 15 1,000 5,154E-04 0,01210648 ! heterophilic cell adhesion GO:0007157 43 16 1,000 5,881E-04 0,0136842 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 5,881E-04 0,0135551 ! biomineral formation GO:0031214 22 16 1,000 5,881E-04 0,01342842 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 5,881E-04 0,01330408 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 6,597E-04 0,0147849 ! monosaccharide catabolic process GO:0046365 125 77 2,000 7,123E-04 0,01581971 ! centrosome cycle GO:0007098 26 18 1,000 7,477E-04 0,01645611 ! cell-substrate junction assembly GO:0007044 56 18 1,000 7,477E-04 0,01630918 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 7,477E-04 0,01616485 ! activation of protein kinase activity GO:0032147 170 80 2,000 7,962E-04 0,01706191 ! memory GO:0007613 34 19 1,000 8,344E-04 0,01772649 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 8,344E-04 0,01757368 ! cerebral cortex development GO:0021987 40 19 1,000 8,344E-04 0,01742348 ! neuromuscular junction development GO:0007528 43 19 1,000 8,344E-04 0,01727582 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 9,258E-04 0,01900628 ! protein amino acid acetylation GO:0006473 41 20 1,000 9,258E-04 0,01884789 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 9,258E-04 0,01869212 ! negative regulation of T cell activation GO:0050868 41 20 1,000 9,258E-04 0,01853891 ! negative regulation of transport GO:0051051 164 85 2,000 9,494E-04 0,01885755 ! alcohol catabolic process GO:0046164 142 87 2,000 1,016E-03 0,02000906 ! lipid phosphorylation GO:0046834 43 21 1,000 1,022E-03 0,01996943 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 1,022E-03 0,01981094 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 1,122E-03 0,02158891 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 1,122E-03 0,02142025 ! cell aging GO:0007569 48 22 1,000 1,122E-03 0,0212542 ! peptidyl-serine modification GO:0018209 50 22 1,000 1,122E-03 0,02109071 ! positive regulation of B cell activation GO:0050871 42 22 1,000 1,122E-03 0,02092971 ! ossification GO:0001503 205 91 2,000 1,157E-03 0,02140465 ! gland development GO:0048732 220 91 2,000 1,157E-03 0,02124371 ! bone development GO:0060348 206 92 2,000 1,194E-03 0,02176077 ! positive regulation of MAP kinase activity GO:0043406 174 93 2,000 1,231E-03 0,02228358 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 1,337E-03 0,02401736 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 1,337E-03 0,02384205 ! pallium development GO:0021543 56 24 1,000 1,337E-03 0,02366928 ! oogenesis GO:0048477 44 24 1,000 1,337E-03 0,023499 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 1,337E-03 0,02333115 ! interphase of mitotic cell cycle GO:0051329 224 98 2,000 1,432E-03 0,02480584 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 1,451E-03 0,02496631 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 1,451E-03 0,02479172 ! leukocyte adhesion GO:0007159 55 25 1,000 1,451E-03 0,02461956 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 1,451E-03 0,02444977 ! negative regulation of DNA replication GO:0008156 45 25 1,000 1,451E-03 0,0242823 ! skeletal muscle tissue development GO:0007519 223 100 2,000 1,517E-03 0,02521433 GO:0060538|skeletal muscle organ development, ! myelination GO:0042552 50 26 1,000 1,57E-03 0,02591252 ! microtubule organizing center organization GO:0031023 42 26 1,000 1,57E-03 0,02573861 GO:0051297|centrosome organization, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 1,57E-03 0,02556702 GO:0045936|negative regulation of phosphate metabolic process, ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 1,57E-03 0,0253977 ! blastocyst development GO:0001824 50 26 1,000 1,57E-03 0,02523061 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 1,693E-03 0,02703151 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 1,693E-03 0,02685598 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 1,82E-03 0,02869336 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 1,82E-03 0,02850943 ! protein amino acid acylation GO:0043543 59 28 1,000 1,82E-03 0,02832784 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 1,952E-03 0,03018958 ! response to organic cyclic substance GO:0014070 58 29 1,000 1,952E-03 0,02999971 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 1,952E-03 0,02981221 ! somitogenesis GO:0001756 52 29 1,000 1,952E-03 0,02962705 ! tissue homeostasis GO:0001894 50 30 1,000 2,089E-03 0,03150136 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 1,000 2,089E-03 0,0313081 ! zinc ion transport GO:0006829 54 31 1,000 2,23E-03 0,03321477 ! cell junction assembly GO:0034329 85 31 1,000 2,23E-03 0,03301347 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 2,23E-03 0,03281459 ! ensheathment of neurons GO:0007272 64 31 1,000 2,23E-03 0,0326181 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 2,23E-03 0,03242394 ! peripheral nervous system development GO:0007422 68 32 1,000 2,375E-03 0,03433083 ! positive regulation of catabolic process GO:0009896 72 32 1,000 2,375E-03 0,03412888 ! response to ionizing radiation GO:0010212 74 33 1,000 2,524E-03 0,0360657 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 2,837E-03 0,04028839 ! telencephalon development GO:0021537 81 35 1,000 2,837E-03 0,04005551 ! calcium-mediated signaling GO:0019722 67 35 1,000 2,837E-03 0,0398253 ! cell junction organization GO:0034330 96 37 1,000 3,166E-03 0,04419395 ! maintenance of protein location in cell GO:0032507 89 37 1,000 3,166E-03 0,04394284 ! female gonad development GO:0008585 71 37 1,000 3,166E-03 0,04369458 ! regulation of microtubule-based process GO:0032886 86 37 1,000 3,166E-03 0,0434491 ! negative regulation of cell activation GO:0050866 69 37 1,000 3,166E-03 0,04320637 ! glycogen metabolic process GO:0005977 63 38 1,000 3,337E-03 0,04528738 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 3,337E-03 0,04503717 ! meiosis I GO:0007127 74 38 1,000 3,337E-03 0,04478972 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 3,512E-03 0,04688451 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 3,512E-03 0,0466297 GO:0006073|cellular glucan metabolic process, ! learning GO:0007612 82 40 1,000 3,691E-03 0,04874759 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 3,691E-03 0,0484855 GO:0046660|female sex differentiation, ! regulation of action potential in neuron GO:0019228 80 40 1,000 3,691E-03 0,04822622 ! maintenance of protein location GO:0045185 95 41 1,000 3,875E-03 0,05035636 ! T cell differentiation GO:0030217 93 42 1,000 4,063E-03 0,05251796 ! regulation of T cell differentiation GO:0045580 78 42 1,000 4,063E-03 0,05224155 ! cytokinesis GO:0000910 84 42 1,000 4,063E-03 0,05196804 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 4,255E-03 0,05414038 GO:0090047|positive regulation of transcription regulator activity, ! glucose transport GO:0015758 66 43 1,000 4,255E-03 0,05385986 ! regulation of T cell proliferation GO:0042129 80 43 1,000 4,255E-03 0,05358224 ! segmentation GO:0035282 78 43 1,000 4,255E-03 0,05330746 ! energy reserve metabolic process GO:0006112 76 44 1,000 4,451E-03 0,05548023 ! hexose transport GO:0008645 68 44 1,000 4,451E-03 0,05519861 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 1,000 4,451E-03 0,05491983 ! female gamete generation GO:0007292 71 45 1,000 4,651E-03 0,05710233 ! developmental growth GO:0048589 88 45 1,000 4,651E-03 0,05681682 ! maintenance of location in cell GO:0051651 101 45 1,000 4,651E-03 0,05653415 ! cell growth GO:0016049 90 46 1,000 4,856E-03 0,05872585 ! response to insulin stimulus GO:0032868 98 47 1,000 5,064E-03 0,06094509 ! positive regulation of DNA binding GO:0043388 83 48 1,000 5,277E-03 0,06319123 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 5,493E-03 0,06546366 ! protein homooligomerization GO:0051260 84 49 1,000 5,493E-03 0,06514587 ! regulation of action potential GO:0001508 102 50 1,000 5,714E-03 0,06743441 ! negative regulation of immune system process GO:0002683 101 51 1,000 5,938E-03 0,06974801 ! positive regulation of binding GO:0051099 88 52 1,000 6,167E-03 0,07208609 ! response to estrogen stimulus GO:0043627 98 52 1,000 6,167E-03 0,07174282 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 6,167E-03 0,07140281 ! histone modification GO:0016570 104 52 1,000 6,167E-03 0,071066 ! synapse organization GO:0050808 102 53 1,000 6,4E-03 0,07339951 ! regulation of angiogenesis GO:0045765 125 54 1,000 6,636E-03 0,07575632 ! activation of phospholipase C activity GO:0007202 110 54 1,000 6,636E-03 0,07540397 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 6,636E-03 0,07505487 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 6,876E-03 0,07741575 ! cell maturation GO:0048469 107 55 1,000 6,876E-03 0,07706063 ! skeletal muscle fiber development GO:0048741 130 56 1,000 7,121E-03 0,07943444 ! regulation of protein catabolic process GO:0042176 126 56 1,000 7,121E-03 0,07907338 ! regulation of DNA replication GO:0006275 105 56 1,000 7,121E-03 0,07871558 ! muscle fiber development GO:0048747 131 57 1,000 7,369E-03 0,08109273 ! regulation of phospholipase activity GO:0010517 113 57 1,000 7,369E-03 0,08072909 ! nucleotide-excision repair GO:0006289 91 57 1,000 7,369E-03 0,08036869 ! positive regulation of cell migration GO:0030335 137 58 1,000 7,621E-03 0,0827489 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 7,621E-03 0,08238275 ! aging GO:0007568 112 58 1,000 7,621E-03 0,08201983 ! positive regulation of lipase activity GO:0060193 115 58 1,000 7,621E-03 0,0816601 ! maintenance of location GO:0051235 124 58 1,000 7,621E-03 0,0813035 ! lipid modification GO:0030258 112 60 1,000 8,137E-03 0,08642858 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 8,668E-03 0,09167101 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 9,214E-03 0,09702774 ! response to peptide hormone stimulus GO:0043434 129 64 1,000 9,214E-03 0,09661131 ! positive regulation of cell motion GO:0051272 157 65 1,000 9,493E-03 0,09910863 ! gonad development GO:0008406 115 66 1,000 9,775E-03 0,1016235 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,01006169 0,10415551 ! regulation of lipase activity GO:0060191 137 68 1,000 0,01035158 0,10670428 ! cell projection assembly GO:0030031 138 68 1,000 0,01035158 0,10625594 ! negative regulation of cell size GO:0045792 144 69 1,000 0,01064516 0,1088122 ! lung development GO:0030324 165 69 1,000 0,01064516 0,10835882 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01064516 0,1079092 ! developmental maturation GO:0021700 128 69 1,000 0,01064516 0,10746329 ! germ cell development GO:0007281 133 70 1,000 0,01094239 0,11000933 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01120374 0,11217516 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01120374 0,1117173 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01120374 0,11126317 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01120374 0,11081271 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01120374 0,11036588 ! neuron fate determination GO:0048664 7 5 0,000 0,01120374 0,10992265 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01120374 0,10948296 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01120374 0,10904677 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01120374 0,10861404 ! polyol transport GO:0015791 12 5 0,000 0,01120374 0,10818474 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01120374 0,10775882 ! response to superoxide GO:0000303 10 5 0,000 0,01120374 0,10733623 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01120374 0,10691695 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01120374 0,10650093 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01120374 0,10608814 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01120374 0,10567853 ! female meiosis GO:0007143 10 5 0,000 0,01120374 0,10527207 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01120374 0,10486873 ! hypothalamus development GO:0021854 9 5 0,000 0,01120374 0,10446847 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01120374 0,10407125 ! cobalt ion transport GO:0006824 11 5 0,000 0,01120374 0,10367704 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01120374 0,10328581 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01120374 0,10289752 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01120374 0,10251213 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01120374 0,10212962 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01120374 0,10174996 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01120374 0,10137311 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01120374 0,10099904 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01120374 0,10062772 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01120374 0,10025912 ! transposition GO:0032196 9 5 0,000 0,01120374 0,09989321 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01120374 0,09952996 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01120374 0,09916935 ! negative chemotaxis GO:0050919 16 5 0,000 0,01120374 0,09881133 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01120374 0,0984559 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01120374 0,09810301 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01120374 0,09775264 ! behavioral response to pain GO:0048266 10 5 0,000 0,01120374 0,09740477 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01120374 0,09705936 ! Notch receptor processing GO:0007220 11 5 0,000 0,01120374 0,09671639 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01120374 0,09637584 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01120374 0,09603768 ! micturition GO:0060073 9 5 0,000 0,01120374 0,09570189 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01120374 0,09536843 ! copulation GO:0007620 9 5 0,000 0,01120374 0,09503729 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01120374 0,09470844 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01120374 0,09438186 ! bioluminescence GO:0008218 9 5 0,000 0,01120374 0,09405752 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01120374 0,09373541 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01120374 0,09341549 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01120374 0,09309775 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01120374 0,09278217 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01120374 0,09246871 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01120374 0,09215737 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01120374 0,09184812 ! grooming behavior GO:0007625 6 5 0,000 0,01120374 0,09154093 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01120374 0,0912358 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01120374 0,09093269 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01120374 0,09063159 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01120374 0,09033247 ! response to protozoan GO:0001562 13 5 0,000 0,01120374 0,09003533 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,01120374 0,08974013 ! lymph vessel development GO:0001945 10 5 0,000 0,01120374 0,08944686 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01120374 0,0891555 ! endochondral ossification GO:0001958 17 5 0,000 0,01120374 0,08886604 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01120374 0,08857844 ! single strand break repair GO:0000012 8 5 0,000 0,01120374 0,08829271 ! parathyroid gland development GO:0060017 14 5 0,000 0,01120374 0,08800881 ! anagen GO:0042640 7 5 0,000 0,01120374 0,08772673 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01120374 0,08744645 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01120374 0,08716796 ! cytokine secretion GO:0050663 15 5 0,000 0,01120374 0,08689124 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01120374 0,08661626 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01120374 0,08634303 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01120374 0,08607151 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01120374 0,08580169 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01120374 0,08553356 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01120374 0,0852671 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01120374 0,0850023 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01120374 0,08473913 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01120374 0,08447759 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01120374 0,08421766 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01120374 0,08395932 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01120374 0,08370257 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01120374 0,08344738 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01120374 0,08319374 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01120374 0,08294163 ! valine metabolic process GO:0006573 12 5 0,000 0,01120374 0,08269106 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01120374 0,08244199 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01120374 0,08219441 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01120374 0,08194832 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01120374 0,0817037 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01120374 0,08146053 ! polyol catabolic process GO:0046174 9 5 0,000 0,01120374 0,08121881 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01120374 0,08097852 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01120374 0,08073964 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01120374 0,08050217 ! muscle cell migration GO:0014812 8 5 0,000 0,01120374 0,0802661 ! mitochondrial fission GO:0000266 8 5 0,000 0,01120374 0,0800314 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01120374 0,07979807 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01120374 0,0795661 ! mRNA transcription GO:0009299 10 5 0,000 0,01120374 0,07933548 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01120374 0,07910618 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01120374 0,07887821 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01120374 0,07865155 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01120374 0,07842619 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01120374 0,07820211 ! monocyte activation GO:0042117 10 5 0,000 0,01120374 0,07797931 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01120374 0,07775778 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01120374 0,0775375 ! response to food GO:0032094 6 5 0,000 0,01120374 0,07731847 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01120374 0,07710067 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01120374 0,0768841 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01120374 0,07666874 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01120374 0,07645458 ! forebrain neuron development GO:0021884 13 5 0,000 0,01120374 0,07624161 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01120374 0,07602983 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01120374 0,07581922 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01120374 0,07560978 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01120374 0,07540149 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01120374 0,07519434 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01120374 0,07498833 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01120374 0,07478344 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01120374 0,07457967 ! lipid glycosylation GO:0030259 7 5 0,000 0,01120374 0,07437701 ! nucleobase transport GO:0015851 6 5 0,000 0,01120374 0,07417545 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01120374 0,07397497 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01120374 0,07377558 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01120374 0,07357726 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01120374 0,07338 ! basic amino acid transport GO:0015802 12 5 0,000 0,01120374 0,07318379 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01120374 0,07298864 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01120374 0,07279452 ! actin nucleation GO:0045010 11 5 0,000 0,01120374 0,07260143 ! depurination GO:0045007 5 5 0,000 0,01120374 0,07240936 ! depyrimidination GO:0045008 10 5 0,000 0,01120374 0,07221831 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01120374 0,07202826 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01120374 0,07183921 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01120374 0,07165115 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01120374 0,07146407 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01120374 0,07127797 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01120374 0,07109283 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01120374 0,07090865 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01120374 0,07072542 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01120374 0,07054314 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01120374 0,0703618 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01120374 0,07018138 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01120374 0,07000189 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01120374 0,06982331 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01120374 0,06964565 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01120374 0,06946888 ! response to arsenic GO:0046685 11 5 0,000 0,01120374 0,06929301 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01120374 0,06911803 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01120374 0,06894393 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01120374 0,0687707 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01120374 0,06859834 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01120374 0,06842685 ! response to mercury ion GO:0046689 8 5 0,000 0,01120374 0,06825621 ! response to cadmium ion GO:0046686 7 5 0,000 0,01120374 0,06808642 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01120374 0,06791747 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01120374 0,06774935 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01120374 0,06758207 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01120374 0,06741561 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01120374 0,06724997 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01120374 0,06708515 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01120374 0,06692112 ! decidualization GO:0046697 11 5 0,000 0,01120374 0,0667579 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01120374 0,06659547 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01120374 0,06643383 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01120374 0,06627298 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01120374 0,0661129 ! embryonic cleavage GO:0040016 6 5 0,000 0,01120374 0,06595359 ! peroxisome fission GO:0016559 5 5 0,000 0,01120374 0,06579505 ! histone demethylation GO:0016577 13 5 0,000 0,01120374 0,06563726 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01120374 0,06548024 ! mitotic recombination GO:0006312 9 5 0,000 0,01120374 0,06532396 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01120374 0,06516843 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01120374 0,06501363 ! metaphase plate congression GO:0051310 7 5 0,000 0,01120374 0,06485957 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01120374 0,06470624 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01120374 0,06455363 ! enteric nervous system development GO:0048484 8 5 0,000 0,01120374 0,06440174 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01120374 0,06425056 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01120374 0,06410009 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01120374 0,06395033 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01120374 0,06380126 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01120374 0,06365288 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01120374 0,0635052 ! B cell homeostasis GO:0001782 13 5 0,000 0,01120374 0,06335819 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01120374 0,06321187 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01120374 0,06306622 ! metaphase GO:0051323 11 5 0,000 0,01120374 0,06292124 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01120374 0,06277692 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01120374 0,06263327 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01120374 0,06249027 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01120374 0,06234793 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01120374 0,06220623 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01120374 0,06206517 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01120374 0,06192475 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01120374 0,06178496 ! response to redox state GO:0051775 6 5 0,000 0,01120374 0,06164581 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01120374 0,06150728 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01120374 0,06136937 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01120374 0,06123208 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01120374 0,0610954 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01120374 0,06095933 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01120374 0,06082387 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01120374 0,060689 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01120374 0,06055473 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01120374 0,06042106 ! striatum development GO:0021756 14 5 0,000 0,01120374 0,06028797 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01120374 0,06015547 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01120374 0,06002355 ! glial cell migration GO:0008347 10 5 0,000 0,01120374 0,05989221 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01120374 0,05976144 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01120374 0,05963124 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01120374 0,05950161 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01120374 0,05937254 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01120374 0,05924402 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01120374 0,05911607 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01120374 0,05898866 ! neuroprotection GO:0043526 8 5 0,000 0,01120374 0,0588618 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01120374 0,05873549 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01120374 0,05860972 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01120374 0,05848449 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01120374 0,05835979 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01120374 0,05823562 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01120374 0,05811197 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01120374 0,05798885 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01120374 0,05786626 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01120374 0,05774418 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01120374 0,05762261 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01120374 0,05750155 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01120374 0,057381 ! spindle assembly GO:0051225 6 5 0,000 0,01120374 0,05726096 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01120374 0,05714142 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01120374 0,05702237 ! protein palmitoylation GO:0018345 12 5 0,000 0,01120374 0,05690382 ! drug metabolic process GO:0017144 7 5 0,000 0,01120374 0,05678577 ! stem cell division GO:0017145 11 5 0,000 0,01120374 0,0566682 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01120374 0,05655111 ! organ regeneration GO:0031100 7 5 0,000 0,01120374 0,05643451 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01120374 0,05631839 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01120374 0,05620275 ! carbohydrate transport GO:0008643 114 72 1,000 0,01154778 0,05780991 ! respiratory tube development GO:0030323 171 72 1,000 0,01154778 0,05769169 ! regulation of caspase activity GO:0043281 136 74 1,000 0,01216761 0,06066424 ! respiratory system development GO:0060541 175 74 1,000 0,01216761 0,06054069 ! organelle localization GO:0051640 155 74 1,000 0,01216761 0,06041764 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,0124829 0,06185745 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 1,000 0,0124829 0,06173224 ! reproductive structure development GO:0048608 131 75 1,000 0,0124829 0,06160752 ! axon guidance GO:0007411 162 75 1,000 0,0124829 0,06148332 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,01280174 0,06292688 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,01312413 0,06438202 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,01312413 0,064253 ! regulation of catabolic process GO:0009894 173 77 1,000 0,01312413 0,06412449 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01342957 0,0654859 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01342957 0,06535545 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01342957 0,06522552 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01342957 0,06509611 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01342957 0,0649672 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01342957 0,06483881 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01342957 0,06471092 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01342957 0,06458354 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01342957 0,06445665 ! response to oxygen radical GO:0000305 11 6 0,000 0,01342957 0,06433027 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01342957 0,06420438 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01342957 0,06407898 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01342957 0,06395407 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01342957 0,06382964 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01342957 0,0637057 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01342957 0,06358224 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01342957 0,06345926 ! forebrain regionalization GO:0021871 9 6 0,000 0,01342957 0,06333675 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01342957 0,06321471 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01342957 0,06309315 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01342957 0,06297205 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01342957 0,06285141 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01342957 0,06273124 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01342957 0,06261152 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01342957 0,06249226 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01342957 0,06237345 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01342957 0,0622551 ! malate metabolic process GO:0006108 13 6 0,000 0,01342957 0,06213719 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01342957 0,06201973 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01342957 0,06190271 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01342957 0,06178613 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01342957 0,06166999 ! protein refolding GO:0042026 15 6 0,000 0,01342957 0,06155429 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01342957 0,06143902 ! opsonization GO:0008228 8 6 0,000 0,01342957 0,06132418 ! mating behavior GO:0007617 7 6 0,000 0,01342957 0,06120977 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01342957 0,06109579 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01342957 0,06098222 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01342957 0,06086909 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01342957 0,06075636 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01342957 0,06064406 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01342957 0,06053217 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01342957 0,06042069 ! toxin metabolic process GO:0009404 11 6 0,000 0,01342957 0,06030963 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01342957 0,06019897 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01342957 0,06008871 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01342957 0,05997886 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01342957 0,05986941 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01342957 0,05976036 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01342957 0,0596517 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01342957 0,05954344 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01342957 0,05943557 ! thymic T cell selection GO:0045061 16 6 0,000 0,01342957 0,0593281 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01342957 0,05922101 ! protein lipoylation GO:0009249 10 6 0,000 0,01342957 0,0591143 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01342957 0,05900798 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01342957 0,05890204 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01342957 0,05879648 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01342957 0,0586913 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01342957 0,05858649 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01342957 0,05848206 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01342957 0,058378 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01342957 0,05827431 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01342957 0,05817099 ! hyperosmotic response GO:0006972 10 6 0,000 0,01342957 0,05806803 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01342957 0,05796544 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01342957 0,0578632 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01342957 0,05776133 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01342957 0,05765982 ! urea metabolic process GO:0019627 7 6 0,000 0,01342957 0,05755866 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01342957 0,05745786 ! neutrophil activation GO:0042119 7 6 0,000 0,01342957 0,05735741 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01342957 0,05725731 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01342957 0,05715756 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01342957 0,05705815 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01342957 0,05695909 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01342957 0,05686038 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01342957 0,056762 ! neuron apoptosis GO:0051402 15 6 0,000 0,01342957 0,05666397 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01342957 0,05656627 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01342957 0,05646891 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01342957 0,05637188 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01342957 0,05627519 ! carnitine transport GO:0015879 10 6 0,000 0,01342957 0,05617883 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01342957 0,0560828 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01342957 0,05598709 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01342957 0,05589172 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01342957 0,05579666 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01342957 0,05570193 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01342957 0,05560752 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01342957 0,05551343 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01342957 0,05541966 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01342957 0,0553262 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01342957 0,05523306 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01342957 0,05514023 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01342957 0,05504771 ! astrocyte development GO:0014002 16 6 0,000 0,01342957 0,05495551 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01342957 0,05486361 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01342957 0,05477202 ! interaction with symbiont GO:0051702 14 6 0,000 0,01342957 0,05468073 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01342957 0,05458975 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01342957 0,05449906 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01342957 0,05440868 ! response to copper ion GO:0046688 10 6 0,000 0,01342957 0,0543186 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01342957 0,05422882 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01342957 0,05413934 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01342957 0,05405014 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01342957 0,05396125 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01342957 0,05387264 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01342957 0,05378432 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01342957 0,0536963 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01342957 0,05360856 ! hair follicle maturation GO:0048820 8 6 0,000 0,01342957 0,0535211 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01342957 0,05343394 ! Schwann cell development GO:0014044 15 6 0,000 0,01342957 0,05334705 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01342957 0,05326045 ! response to pheromone GO:0019236 6 6 0,000 0,01342957 0,05317413 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01342957 0,05308809 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01342957 0,05300232 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01342957 0,05291683 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01342957 0,05283162 ! subpallium development GO:0021544 15 6 0,000 0,01342957 0,05274668 ! neural tube patterning GO:0021532 8 6 0,000 0,01342957 0,05266202 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01342957 0,05257762 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01342957 0,0524935 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01342957 0,05240964 ! G2 phase GO:0051319 16 6 0,000 0,01342957 0,05232606 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01342957 0,05224273 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01342957 0,05215968 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01342957 0,05207688 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01342957 0,05199435 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01342957 0,05191208 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01342957 0,05183007 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01342957 0,05174832 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01342957 0,05166683 ! receptor internalization GO:0031623 11 6 0,000 0,01342957 0,05158559 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01342957 0,05150461 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01342957 0,05142388 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01342957 0,05134341 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01342957 0,05126318 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01342957 0,05118321 ! protein deubiquitination GO:0016579 16 6 0,000 0,01342957 0,05110348 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01342957 0,05102401 ! protein destabilization GO:0031648 9 6 0,000 0,01342957 0,05094478 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01342957 0,05086579 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01342957 0,05078705 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01342957 0,05070856 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01342957 0,0506303 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01342957 0,05055229 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01342957 0,05047452 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01342957 0,05039698 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01342957 0,05031969 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01342957 0,05024263 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01342957 0,05016581 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01342957 0,05008922 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01342957 0,05001286 ! neural plate development GO:0001840 9 6 0,000 0,01342957 0,04993674 ! catecholamine transport GO:0051937 9 6 0,000 0,01342957 0,04986085 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01342957 0,04978519 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01342957 0,04970975 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01342957 0,04963455 ! maternal placenta development GO:0001893 12 6 0,000 0,01342957 0,04955957 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01342957 0,04948482 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01342957 0,0494103 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01342957 0,049336 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01342957 0,04926192 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01342957 0,04918806 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01342957 0,04911443 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01342957 0,04904101 GO:0055081|anion homeostasis, ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,01345004 0,04904245 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,01377945 0,05016871 ! protein oligomerization GO:0051259 149 79 1,000 0,01377945 0,05009405 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,01411236 0,05122807 ! response to hypoxia GO:0001666 178 81 1,000 0,01444873 0,0523713 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,01444873 0,05229372 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,01478857 0,05344448 ! response to oxygen levels GO:0070482 183 83 1,000 0,01513184 0,05460426 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,01513184 0,05452372 GO:0045937|positive regulation of phosphate metabolic process, ! T cell activation GO:0042110 189 84 1,000 0,01547853 0,0556908 ! response to nutrient GO:0007584 135 84 1,000 0,01547853 0,0556089 ! tRNA transcription GO:0009304 17 7 0,000 0,01565045 0,05614397 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01565045 0,05606165 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01565045 0,05597957 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01565045 0,05589773 ! regulation of helicase activity GO:0051095 16 7 0,000 0,01565045 0,05581613 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01565045 0,05573476 ! sleep GO:0030431 16 7 0,000 0,01565045 0,05565363 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01565045 0,05557274 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01565045 0,05549209 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01565045 0,05541166 ! prostate gland development GO:0030850 14 7 0,000 0,01565045 0,05533147 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01565045 0,05525151 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01565045 0,05517178 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01565045 0,05509229 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01565045 0,05501302 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01565045 0,05493398 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01565045 0,05485516 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01565045 0,05477657 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01565045 0,05469821 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01565045 0,05462007 ! glycolipid transport GO:0046836 11 7 0,000 0,01565045 0,05454215 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01565045 0,05446445 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,01565045 0,05438698 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,01565045 0,05430973 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01565045 0,05423269 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01565045 0,05415587 ! mRNA stabilization GO:0048255 18 7 0,000 0,01565045 0,05407927 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,01565045 0,05400289 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01565045 0,05392672 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01565045 0,05385077 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01565045 0,05377503 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01565045 0,0536995 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01565045 0,05362419 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01565045 0,05354909 ! lipoprotein transport GO:0042953 14 7 0,000 0,01565045 0,05347419 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01565045 0,05339951 ! rhythmic behavior GO:0007622 17 7 0,000 0,01565045 0,05332503 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01565045 0,05325076 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01565045 0,0531767 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01565045 0,05310284 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01565045 0,05302919 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01565045 0,05295574 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01565045 0,0528825 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01565045 0,05280946 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01565045 0,05273662 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01565045 0,05266398 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01565045 0,05259154 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01565045 0,0525193 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01565045 0,05244725 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01565045 0,05237541 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01565045 0,05230376 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01565045 0,0522323 ! spinal cord patterning GO:0021511 14 7 0,000 0,01565045 0,05216105 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01565045 0,05208998 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01565045 0,05201911 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01565045 0,05194843 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01565045 0,05187795 ! adrenal gland development GO:0030325 17 7 0,000 0,01565045 0,05180765 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01565045 0,05173755 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01565045 0,05166763 ! ovulation GO:0030728 10 7 0,000 0,01565045 0,0515979 ! adenohypophysis development GO:0021984 11 7 0,000 0,01565045 0,05152837 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01565045 0,05145901 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01565045 0,05138985 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01565045 0,05132087 ! microtubule nucleation GO:0007020 21 7 0,000 0,01565045 0,05125207 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01565045 0,05118346 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01565045 0,05111504 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01565045 0,05104679 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01565045 0,05097873 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01565045 0,05091085 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01565045 0,05084315 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01565045 0,05077563 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01565045 0,05070829 ! galactose metabolic process GO:0006012 13 7 0,000 0,01565045 0,05064112 ! vesicle fusion GO:0006906 20 7 0,000 0,01565045 0,05057414 ! response to dietary excess GO:0002021 8 7 0,000 0,01565045 0,05050733 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01565045 0,0504407 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01565045 0,05037424 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01565045 0,05030796 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01565045 0,05024185 ! organ growth GO:0035265 15 7 0,000 0,01565045 0,05017591 ! nucleoside transport GO:0015858 11 7 0,000 0,01565045 0,05011015 ! nucleoside salvage GO:0043174 11 7 0,000 0,01565045 0,05004456 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01565045 0,04997915 ! male sex determination GO:0030238 15 7 0,000 0,01565045 0,0499139 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01565045 0,04984882 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01565045 0,04978392 ! parturition GO:0007567 16 7 0,000 0,01565045 0,04971918 ! rRNA modification GO:0000154 14 7 0,000 0,01565045 0,04965461 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01565045 0,0495902 ! spindle checkpoint GO:0031577 16 7 0,000 0,01565045 0,04952597 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01565045 0,0494619 ! monocyte differentiation GO:0030224 16 7 0,000 0,01565045 0,04939799 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01565045 0,04933425 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01565045 0,04927068 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01565045 0,04920727 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,01565045 0,04914402 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01565045 0,04908093 ! fibrinolysis GO:0042730 11 7 0,000 0,01565045 0,04901801 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01565045 0,04895525 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01565045 0,04889264 ! eating behavior GO:0042755 8 7 0,000 0,01565045 0,0488302 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01565045 0,04876792 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01565045 0,04870579 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01565045 0,04864383 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01565045 0,04858202 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01565045 0,04852036 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,01565045 0,04845887 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01565045 0,04839753 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01565045 0,04833634 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01565045 0,04827531 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01565045 0,04821443 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01565045 0,04815371 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01565045 0,04809314 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01565045 0,04803272 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01565045 0,04797246 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01565045 0,04791234 ! histone ubiquitination GO:0016574 9 7 0,000 0,01565045 0,04785237 ! regulation of meiosis GO:0040020 12 7 0,000 0,01565045 0,04779256 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01565045 0,04773289 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01565045 0,04767338 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01565045 0,04761401 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01565045 0,04755478 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01565045 0,04749571 ! transcription termination GO:0006353 14 7 0,000 0,01565045 0,04743678 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01565045 0,047378 ! anaphase GO:0051322 18 7 0,000 0,01565045 0,04731937 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01565045 0,04726087 ! axonal fasciculation GO:0007413 19 7 0,000 0,01565045 0,04720253 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01565045 0,04714432 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01565045 0,04708626 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01565045 0,04702835 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01565045 0,04697057 ! diuresis GO:0030146 12 7 0,000 0,01565045 0,04691294 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01565045 0,04685545 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01565045 0,0467981 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01565045 0,04674089 ! antibiotic transport GO:0042891 9 7 0,000 0,01565045 0,04668382 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01565045 0,04662689 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01565045 0,04657009 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01565045 0,04651344 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01565045 0,04645692 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01565045 0,04640054 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01565045 0,0463443 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01565045 0,04628819 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01565045 0,04623222 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01565045 0,04617639 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01565045 0,04612068 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01565045 0,04606512 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01565045 0,04600968 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01565045 0,04595438 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01565045 0,04589922 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01565045 0,04584418 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01565045 0,04578928 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01565045 0,04573451 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01565045 0,04567986 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01565045 0,04562535 ! muscle adaptation GO:0043500 13 7 0,000 0,01565045 0,04557097 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01565045 0,04551672 ! retina homeostasis GO:0001895 12 7 0,000 0,01565045 0,0454626 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01565045 0,04540861 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01565045 0,04535474 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,01565045 0,045301 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01565045 0,04524739 ! negative regulation of growth GO:0045926 168 85 1,000 0,01582863 0,04570844 ! cellular response to hormone stimulus GO:0032870 182 85 1,000 0,01582863 0,04565448 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,01618212 0,046619 GO:0002696|positive regulation of leukocyte activation, ! regulation of DNA binding GO:0051101 167 89 1,000 0,01726274 0,0496736 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,01762962 0,0506696 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,01786639 0,05128977 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,01786639 0,05122957 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,01786639 0,05116951 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,01786639 0,0511096 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,01786639 0,05104982 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,01786639 0,05099018 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,01786639 0,05093068 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,01786639 0,05087132 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,01786639 0,0508121 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,01786639 0,05075302 ! meiotic prophase I GO:0007128 14 8 0,000 0,01786639 0,05069407 ! response to zinc ion GO:0010043 12 8 0,000 0,01786639 0,05063526 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,01786639 0,05057659 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,01786639 0,05051805 ! oligopeptide transport GO:0006857 16 8 0,000 0,01786639 0,05045965 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,01786639 0,05040138 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,01786639 0,05034325 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,01786639 0,05028525 ! signal peptide processing GO:0006465 12 8 0,000 0,01786639 0,05022738 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,01786639 0,05016965 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,01786639 0,05011205 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,01786639 0,05005458 ! succinate metabolic process GO:0006105 17 8 0,000 0,01786639 0,04999725 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,01786639 0,04994004 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,01786639 0,04988297 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,01786639 0,04982602 ! estrogen metabolic process GO:0008210 17 8 0,000 0,01786639 0,04976921 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,01786639 0,04971252 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,01786639 0,04965597 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,01786639 0,04959954 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,01786639 0,04954324 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01786639 0,04948707 ! reflex GO:0060004 17 8 0,000 0,01786639 0,04943103 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,01786639 0,04937511 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,01786639 0,04931932 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,01786639 0,04926365 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,01786639 0,04920811 ! pigment granule organization GO:0048753 17 8 0,000 0,01786639 0,0491527 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,01786639 0,04909741 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,01786639 0,04904224 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,01786639 0,0489872 ! astrocyte differentiation GO:0048708 19 8 0,000 0,01786639 0,04893228 ! histidine catabolic process GO:0006548 10 8 0,000 0,01786639 0,04887749 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,01786639 0,04882281 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,01786639 0,04876826 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,01786639 0,04871383 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,01786639 0,04865953 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,01786639 0,04860534 ! melanin metabolic process GO:0006582 17 8 0,000 0,01786639 0,04855127 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,01786639 0,04849733 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,01786639 0,0484435 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,01786639 0,0483898 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,01786639 0,04833621 ! macrophage activation GO:0042116 13 8 0,000 0,01786639 0,04828274 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,01786639 0,04822939 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,01786639 0,04817615 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,01786639 0,04812304 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,01786639 0,04807004 ! purine salvage GO:0043101 12 8 0,000 0,01786639 0,04801716 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,01786639 0,04796439 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01786639 0,04791174 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,01786639 0,04785921 ! osteoblast development GO:0002076 17 8 0,000 0,01786639 0,04780679 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,01786639 0,04775448 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,01786639 0,04770229 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,01786639 0,04765021 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,01786639 0,04759825 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,01786639 0,0475464 ! response to UV-B GO:0010224 17 8 0,000 0,01786639 0,04749466 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,01786639 0,04744304 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,01786639 0,04739153 ! intermediate filament organization GO:0045109 12 8 0,000 0,01786639 0,04734013 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,01786639 0,04728884 ! cellular extravasation GO:0045123 13 8 0,000 0,01786639 0,04723766 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,01786639 0,04718659 ! response to antibiotic GO:0046677 11 8 0,000 0,01786639 0,04713563 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,01786639 0,04708478 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,01786639 0,04703405 ! DNA topological change GO:0006265 12 8 0,000 0,01786639 0,04698342 ! response to tropane GO:0014073 15 8 0,000 0,01786639 0,0469329 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,01786639 0,04688249 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,01786639 0,04683218 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,01786639 0,04678199 ! mast cell activation GO:0045576 14 8 0,000 0,01786639 0,0467319 ! multicellular organismal aging GO:0010259 20 8 0,000 0,01786639 0,04668192 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,01786639 0,04663205 ! gas homeostasis GO:0033483 14 8 0,000 0,01786639 0,04658228 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,01786639 0,04653262 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,01786639 0,04648306 ! nucleosome disassembly GO:0006337 14 8 0,000 0,01786639 0,04643361 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,01786639 0,04638427 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,01786639 0,04633503 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,01786639 0,04628589 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,01786639 0,04623686 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,01786639 0,04618793 ! intracellular lipid transport GO:0032365 16 8 0,000 0,01786639 0,04613911 ! response to tumor cell GO:0002347 16 8 0,000 0,01786639 0,04609039 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,01786639 0,04604177 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,01786639 0,04599325 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,01786639 0,04594484 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,01786639 0,04589653 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,01786639 0,04584831 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,01786639 0,04580021 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,01786639 0,0457522 ! hormone catabolic process GO:0042447 17 8 0,000 0,01786639 0,04570429 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,01786639 0,04565648 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,01786639 0,04560877 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,01786639 0,04556116 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,01786639 0,04551366 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,01786639 0,04546625 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,01786639 0,04541893 ! adult feeding behavior GO:0008343 10 8 0,000 0,01786639 0,04537172 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,01786639 0,04532461 ! ATP catabolic process GO:0006200 11 8 0,000 0,01786639 0,04527759 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,01786639 0,04523067 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,01786639 0,04518385 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,01786639 0,04513712 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,01786639 0,04509049 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,01786639 0,04504396 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,01786639 0,04499752 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,01786639 0,04495118 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,01786639 0,04490493 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,01786639 0,04485878 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,01786639 0,04481273 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,01786639 0,04476676 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,01786639 0,0447209 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,01786639 0,04467512 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,01786639 0,04462944 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,01786639 0,04458386 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,01786639 0,04453836 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,01786639 0,04449296 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,01786639 0,04444765 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,01786639 0,04440244 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,01786639 0,04435731 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,01837327 0,04556945 ! regulation of membrane potential GO:0042391 179 94 1,000 0,01913002 0,04739821 ! sex differentiation GO:0007548 171 96 1,000 0,01989973 0,04925536 ! regulation of T cell activation GO:0050863 175 96 1,000 0,01989973 0,04920551 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,02007741 0,04959465 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02007741 0,04954455 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02007741 0,04949456 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02007741 0,04944467 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02007741 0,04939487 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02007741 0,04934518 ! reproductive behavior GO:0019098 22 9 0,000 0,02007741 0,04929559 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02007741 0,04924609 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02007741 0,0491967 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02007741 0,0491474 ! UTP metabolic process GO:0046051 10 9 0,000 0,02007741 0,04909821 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02007741 0,04904911 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,02007741 0,04900011 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02007741 0,04895121 ! artery development GO:0060840 25 9 0,000 0,02007741 0,0489024 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02007741 0,04885369 ! regulation of glycolysis GO:0006110 20 9 0,000 0,02007741 0,04880508 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02007741 0,04875657 ! equilibrioception GO:0050957 20 9 0,000 0,02007741 0,04870815 ! chemosensory behavior GO:0007635 21 9 0,000 0,02007741 0,04865983 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02007741 0,0486116 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02007741 0,04856347 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02007741 0,04851544 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02007741 0,0484675 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02007741 0,04841965 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02007741 0,0483719 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02007741 0,04832425 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02007741 0,04827668 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02007741 0,04822921 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02007741 0,04818184 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02007741 0,04813455 ! protein targeting to ER GO:0045047 25 9 0,000 0,02007741 0,04808736 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02007741 0,04804026 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02007741 0,04799326 ! T cell selection GO:0045058 27 9 0,000 0,02007741 0,04794634 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02007741 0,04789952 ! glycine catabolic process GO:0006546 15 9 0,000 0,02007741 0,04785279 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02007741 0,04780615 ! endosome organization GO:0007032 20 9 0,000 0,02007741 0,0477596 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02007741 0,04771314 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02007741 0,04766677 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02007741 0,04762049 ! mannose metabolic process GO:0006013 13 9 0,000 0,02007741 0,04757431 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02007741 0,04752821 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02007741 0,0474822 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02007741 0,04743628 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02007741 0,04739044 ! receptor clustering GO:0043113 20 9 0,000 0,02007741 0,0473447 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02007741 0,04729904 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02007741 0,04725348 ! retinol metabolic process GO:0042572 20 9 0,000 0,02007741 0,047208 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02007741 0,04716261 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02007741 0,0471173 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02007741 0,04707208 ! macrophage differentiation GO:0030225 15 9 0,000 0,02007741 0,04702695 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02007741 0,04698191 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02007741 0,04693695 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02007741 0,04689207 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02007741 0,04684729 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02007741 0,04680259 ! response to amine stimulus GO:0014075 13 9 0,000 0,02007741 0,04675797 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02007741 0,04671344 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02007741 0,04666899 ! erythrocyte development GO:0048821 17 9 0,000 0,02007741 0,04662463 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02007741 0,04658035 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02007741 0,04653616 ! renal water homeostasis GO:0003091 15 9 0,000 0,02007741 0,04649205 ! postreplication repair GO:0006301 25 9 0,000 0,02007741 0,04644802 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02007741 0,04640408 ! icosanoid secretion GO:0032309 15 9 0,000 0,02007741 0,04636022 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02007741 0,04631644 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02007741 0,04627274 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02007741 0,04622913 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02007741 0,0461856 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02007741 0,04614215 ! sterol catabolic process GO:0016127 14 9 0,000 0,02007741 0,04609879 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02007741 0,0460555 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02007741 0,0460123 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02007741 0,04596917 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02007741 0,04592613 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,02007741 0,04588317 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02007741 0,04584029 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02007741 0,04579749 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02007741 0,04575477 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02007741 0,04571212 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02007741 0,04566956 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02007741 0,04562708 ! purine base metabolic process GO:0006144 25 9 0,000 0,02007741 0,04558467 ! pigment granule transport GO:0051904 17 9 0,000 0,02007741 0,04554235 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02007741 0,0455001 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02007741 0,04545793 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02007741 0,04541584 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02007741 0,04537383 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02007741 0,04533189 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02007741 0,04529004 ! mitochondrion localization GO:0051646 18 9 0,000 0,02007741 0,04524826 ! regulation of DNA metabolic process GO:0051052 188 97 1,000 0,02028941 0,04568389 ! leukocyte differentiation GO:0002521 232 98 1,000 0,02068228 0,0465256 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02228351 0,05008152 ! regulation of developmental growth GO:0048638 16 10 0,000 0,02228351 0,05003549 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02228351 0,04998955 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02228351 0,04994368 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02228351 0,04989791 ! associative learning GO:0008306 21 10 0,000 0,02228351 0,04985221 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02228351 0,0498066 ! phosphate transport GO:0006817 24 10 0,000 0,02228351 0,04976107 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02228351 0,04971563 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02228351 0,04967027 ! CTP metabolic process GO:0046036 11 10 0,000 0,02228351 0,04962499 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02228351 0,04957979 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02228351 0,04953468 ! GTP metabolic process GO:0046039 11 10 0,000 0,02228351 0,04948965 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02228351 0,0494447 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02228351 0,04939983 ! social behavior GO:0035176 29 10 0,000 0,02228351 0,04935504 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02228351 0,04931034 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02228351 0,04926571 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02228351 0,04922117 ! androgen metabolic process GO:0008209 17 10 0,000 0,02228351 0,04917671 ! phospholipid efflux GO:0033700 19 10 0,000 0,02228351 0,04913232 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02228351 0,04908802 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02228351 0,0490438 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02228351 0,04899965 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02228351 0,04895559 ! lung alveolus development GO:0048286 26 10 0,000 0,02228351 0,0489116 ! pathogenesis GO:0009405 17 10 0,000 0,02228351 0,0488677 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02228351 0,04882387 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02228351 0,04878012 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02228351 0,04873645 ! endoderm development GO:0007492 18 10 0,000 0,02228351 0,04869286 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02228351 0,04864934 ! arginine catabolic process GO:0006527 17 10 0,000 0,02228351 0,04860591 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02228351 0,04856255 ! proline metabolic process GO:0006560 13 10 0,000 0,02228351 0,04851926 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02228351 0,04847606 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02228351 0,04843293 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02228351 0,04838988 ! V(D)J recombination GO:0033151 34 10 0,000 0,02228351 0,0483469 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02228351 0,04830401 ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02228351 0,04826118 ! B cell proliferation GO:0042100 19 10 0,000 0,02228351 0,04821844 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02228351 0,04817577 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02228351 0,04813317 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02228351 0,04809065 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02228351 0,0480482 ! ruffle organization GO:0031529 17 10 0,000 0,02228351 0,04800583 ! epithelial cell development GO:0002064 21 10 0,000 0,02228351 0,04796354 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02228351 0,04792132 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02228351 0,04787917 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02228351 0,0478371 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02228351 0,0477951 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02228351 0,04775317 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02228351 0,04771132 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,02228351 0,04766954 ! regulation of bone resorption GO:0045124 25 10 0,000 0,02228351 0,04762783 ! protein heterooligomerization GO:0051291 17 10 0,000 0,02228351 0,0475862 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02228351 0,04754464 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02228351 0,04750315 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02228351 0,04746174 ! segment specification GO:0007379 15 10 0,000 0,02228351 0,0474204 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02228351 0,04737912 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02228351 0,04733793 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02228351 0,0472968 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02228351 0,04725574 ! response to dsRNA GO:0043331 23 10 0,000 0,02228351 0,04721476 ! DNA ligation GO:0006266 18 10 0,000 0,02228351 0,04717384 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02228351 0,047133 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02228351 0,04709223 ! melanosome localization GO:0032400 16 10 0,000 0,02228351 0,04705153 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02228351 0,04701089 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02228351 0,04697033 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02228351 0,04692984 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02228351 0,04688942 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02228351 0,04684907 ! induction of an organ GO:0001759 17 10 0,000 0,02228351 0,04680878 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02228351 0,04676857 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02228351 0,04672842 ! protein sumoylation GO:0016925 17 10 0,000 0,02228351 0,04668835 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02228351 0,04664834 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02228351 0,0466084 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02228351 0,04656853 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02228351 0,04652873 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02228351 0,046489 ! salivary gland development GO:0007431 28 10 0,000 0,02228351 0,04644933 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02228351 0,04640973 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02228351 0,0463702 ! midbrain development GO:0030901 14 10 0,000 0,02228351 0,04633074 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02228351 0,04629134 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02228351 0,04625201 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02228351 0,04621275 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02228351 0,04617355 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02228351 0,04613442 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02228351 0,04609536 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02228351 0,04605636 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02228351 0,04601743 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02228351 0,04597856 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,02228351 0,04593976 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,02228351 0,04590102 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02228351 0,04586235 ! blastocyst formation GO:0001825 18 10 0,000 0,02228351 0,04582375 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02228351 0,04578521 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02228351 0,04574673 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02228351 0,04570832 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02228351 0,04566998 ! response to nicotine GO:0035094 20 10 0,000 0,02228351 0,0456317 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02228351 0,04559348 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,02228351 0,04555533 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,02448471 0,05001349 ! respiratory burst GO:0045730 17 11 0,000 0,02448471 0,04997171 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,02448471 0,04993 ! neuron fate specification GO:0048665 18 11 0,000 0,02448471 0,04988836 ! telencephalon cell migration GO:0022029 23 11 0,000 0,02448471 0,04984678 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,02448471 0,04980528 ! thyroid gland development GO:0030878 26 11 0,000 0,02448471 0,04976384 ! synapsis GO:0007129 14 11 0,000 0,02448471 0,04972248 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,02448471 0,04968118 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,02448471 0,04963995 ! response to pain GO:0048265 27 11 0,000 0,02448471 0,04959879 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,02448471 0,04955769 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,02448471 0,04951667 ! blood vessel remodeling GO:0001974 30 11 0,000 0,02448471 0,04947571 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,02448471 0,04943482 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,02448471 0,049394 ! bone resorption GO:0045453 16 11 0,000 0,02448471 0,04935325 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,02448471 0,04931256 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,02448471 0,04927194 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,02448471 0,04923139 ! melanocyte differentiation GO:0030318 20 11 0,000 0,02448471 0,0491909 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,02448471 0,04915048 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,02448471 0,04911013 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,02448471 0,04906984 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,02448471 0,04902962 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,02448471 0,04898947 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,02448471 0,04894938 ! UV protection GO:0009650 20 11 0,000 0,02448471 0,04890935 ! adult heart development GO:0007512 16 11 0,000 0,02448471 0,04886939 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,02448471 0,0488295 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,02448471 0,04878967 ! macroautophagy GO:0016236 19 11 0,000 0,02448471 0,04874991 ! temperature homeostasis GO:0001659 18 11 0,000 0,02448471 0,04871021 ! behavioral fear response GO:0001662 27 11 0,000 0,02448471 0,04867058 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,02448471 0,04863101 ! negative regulation of ossification GO:0030279 27 11 0,000 0,02448471 0,0485915 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,02448471 0,04855206 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,02448471 0,04851268 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,02448471 0,04847337 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,02448471 0,04843412 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,02448471 0,04839493 ! regulation of organ growth GO:0046620 14 11 0,000 0,02448471 0,04835581 ! pigment granule localization GO:0051875 20 11 0,000 0,02448471 0,04831675 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,02448471 0,04827775 ! vasoconstriction GO:0042310 20 11 0,000 0,02448471 0,04823882 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,02448471 0,04819995 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,02448471 0,04816114 ! embryonic axis specification GO:0000578 19 11 0,000 0,02448471 0,0481224 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,02448471 0,04808371 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,02448471 0,04804509 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,02448471 0,04800653 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,02448471 0,04796803 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,02448471 0,0479296 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,02448471 0,04789122 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,02448471 0,04785291 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,02448471 0,04781466 ! prophase GO:0051324 17 11 0,000 0,02448471 0,04777647 ! neuroblast proliferation GO:0007405 25 11 0,000 0,02448471 0,04773834 ! nucleosome positioning GO:0016584 15 11 0,000 0,02448471 0,04770027 ! regulation of isotype switching GO:0045191 24 11 0,000 0,02448471 0,04766226 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,02448471 0,04762431 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,02448471 0,04758643 ! apical protein localization GO:0045176 18 11 0,000 0,02448471 0,0475486 ! acid secretion GO:0046717 20 11 0,000 0,02448471 0,04751083 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,02448471 0,04747313 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,02448471 0,04743548 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,02448471 0,04739789 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,02448471 0,04736036 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,02448471 0,04732289 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,02448471 0,04728548 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,02448471 0,04724813 ! cholesterol efflux GO:0033344 21 11 0,000 0,02448471 0,04721084 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,02448471 0,04717361 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,02448471 0,04713644 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,02448471 0,04709932 ! embryonic gut development GO:0048566 19 11 0,000 0,02448471 0,04706226 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,02448471 0,04702527 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,02448471 0,04698833 ! activation of innate immune response GO:0002218 16 11 0,000 0,02448471 0,04695144 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,02448471 0,04691462 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,02448471 0,04687785 ! lysogeny GO:0030069 22 11 0,000 0,02448471 0,04684114 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,02448471 0,04680449 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,02448471 0,0467679 ! sequestering of metal ion GO:0051238 15 11 0,000 0,02448471 0,04673136 ! regulation of embryonic development GO:0045995 35 11 0,000 0,02448471 0,04669488 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,02668101 0,05084376 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,02668101 0,05080414 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,02668101 0,05076457 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,02668101 0,05072506 ! virus-host interaction GO:0019048 30 12 0,000 0,02668101 0,05068562 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,02668101 0,05064624 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,02668101 0,05060691 ! protein complex disassembly GO:0043241 28 12 0,000 0,02668101 0,05056765 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,02668101 0,05052845 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,02668101 0,05048931 ! hippocampus development GO:0021766 29 12 0,000 0,02668101 0,05045024 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,02668101 0,05041122 ! T cell proliferation GO:0042098 32 12 0,000 0,02668101 0,05037226 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,02668101 0,05033336 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,02668101 0,05029453 ! ventral spinal cord development GO:0021517 25 12 0,000 0,02668101 0,05025575 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,02668101 0,05021703 ! drug transport GO:0015893 16 12 0,000 0,02668101 0,05017837 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,02668101 0,05013977 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,02668101 0,05010123 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,02668101 0,05006275 ! polyamine metabolic process GO:0006595 18 12 0,000 0,02668101 0,05002433 ! focal adhesion formation GO:0048041 37 12 0,000 0,02668101 0,04998597 ! mitotic spindle organization GO:0007052 23 12 0,000 0,02668101 0,04994767 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,02668101 0,04990942 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,02668101 0,04987124 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,02668101 0,04983311 ! lipid digestion GO:0044241 21 12 0,000 0,02668101 0,04979504 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,02668101 0,04975703 ! entry into host cell GO:0030260 34 12 0,000 0,02668101 0,04971907 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02668101 0,04968118 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,02668101 0,04964334 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,02668101 0,04960556 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,02668101 0,04956784 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,02668101 0,04953017 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,02668101 0,04949256 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,02668101 0,04945501 ! snRNA metabolic process GO:0016073 30 12 0,000 0,02668101 0,04941752 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,02668101 0,04938008 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,02668101 0,0493427 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,02668101 0,04930537 ! cranial nerve development GO:0021545 23 12 0,000 0,02668101 0,04926811 ! fucose catabolic process GO:0019317 25 12 0,000 0,02668101 0,0492309 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,02668101 0,04919374 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,02668101 0,04915664 ! autonomic nervous system development GO:0048483 24 12 0,000 0,02668101 0,0491196 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,02668101 0,04908261 ! zymogen activation GO:0031638 18 12 0,000 0,02668101 0,04904568 ! T cell homeostasis GO:0043029 28 12 0,000 0,02668101 0,0490088 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,02668101 0,04897198 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,02668101 0,04893521 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,02668101 0,0488985 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,02668101 0,04886185 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,02668101 0,04882525 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,02668101 0,0487887 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,02668101 0,04875221 ! defense response to fungus GO:0050832 15 12 0,000 0,02668101 0,04871577 ! developmental induction GO:0031128 22 12 0,000 0,02668101 0,04867939 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,02668101 0,04864306 ! lamellipodium assembly GO:0030032 24 12 0,000 0,02668101 0,04860679 ! response to cold GO:0009409 17 12 0,000 0,02668101 0,04857057 ! establishment of cell polarity GO:0030010 21 12 0,000 0,02668101 0,0485344 ! regulation of synapse organization GO:0050807 18 12 0,000 0,02668101 0,04849829 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,02887243 0,05244263 ! cGMP metabolic process GO:0046068 18 13 0,000 0,02887243 0,05240367 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,02887243 0,05236477 ! regulation of chemokine production GO:0032642 18 13 0,000 0,02887243 0,05232592 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,02887243 0,05228713 ! peroxisomal transport GO:0043574 28 13 0,000 0,02887243 0,0522484 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,02887243 0,05220973 ! cartilage condensation GO:0001502 22 13 0,000 0,02887243 0,05217111 ! organelle fusion GO:0048284 36 13 0,000 0,02887243 0,05213255 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,02887243 0,05209405 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,02887243 0,0520556 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,02887243 0,05201721 ! endocrine pancreas development GO:0031018 25 13 0,000 0,02887243 0,05197888 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,02887243 0,05194061 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,02887243 0,05190239 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,02887243 0,05186422 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,02887243 0,05182612 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,02887243 0,05178806 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,02887243 0,05175007 ! methionine metabolic process GO:0006555 31 13 0,000 0,02887243 0,05171213 ! plasma membrane organization GO:0007009 27 13 0,000 0,02887243 0,05167424 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,02887243 0,05163642 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,02887243 0,05159864 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,02887243 0,05156092 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,02887243 0,05152326 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,02887243 0,05148565 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,02887243 0,0514481 ! exocrine system development GO:0035272 34 13 0,000 0,02887243 0,0514106 ! asymmetric protein localization GO:0008105 24 13 0,000 0,02887243 0,05137316 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,02887243 0,05133577 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,02887243 0,05129843 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,02887243 0,05126115 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,02887243 0,05122392 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,02887243 0,05118675 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,02887243 0,05114963 ! protein homotetramerization GO:0051289 24 13 0,000 0,02887243 0,05111257 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,02887243 0,05107556 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,02887243 0,0510386 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,02887243 0,05100169 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,02887243 0,05096484 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,02887243 0,05092805 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,02887243 0,0508913 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,02887243 0,05085461 ! histone methylation GO:0016571 29 13 0,000 0,02887243 0,05081797 ! chromatin silencing GO:0006342 29 13 0,000 0,02887243 0,05078138 ! gland morphogenesis GO:0022612 31 13 0,000 0,02887243 0,05074485 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,02887243 0,05070837 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,02887243 0,05067194 ! regulation of epidermis development GO:0045682 19 13 0,000 0,02887243 0,05063557 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,02887243 0,05059924 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,02887243 0,05056297 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,02887243 0,05052675 ! spleen development GO:0048536 24 13 0,000 0,02887243 0,05049058 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,02887243 0,05045447 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,02887243 0,0504184 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,02887243 0,05038239 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,02887243 0,05034643 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,02887243 0,05031052 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,02887243 0,05027466 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,02887243 0,05023885 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,02887243 0,05020309 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,02887243 0,05016738 ! insulin secretion GO:0030073 24 13 0,000 0,02887243 0,05013173 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,02887243 0,05009612 ! acrosome reaction GO:0007340 19 13 0,000 0,02887243 0,05006057 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,02887243 0,05002507 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,02887243 0,04998961 ! rRNA transcription GO:0009303 28 14 0,000 0,03105898 0,05373731 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,03105898 0,05369928 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,03105898 0,0536613 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,03105898 0,05362338 ! non-recombinational repair GO:0000726 29 14 0,000 0,03105898 0,05358551 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,03105898 0,05354769 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,03105898 0,05350993 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,03105898 0,05347222 ! RNA polyadenylation GO:0043631 32 14 0,000 0,03105898 0,05343456 ! lipid localization GO:0010876 32 14 0,000 0,03105898 0,05339696 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,03105898 0,05335941 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,03105898 0,05332191 ! regulated secretory pathway GO:0045055 24 14 0,000 0,03105898 0,05328446 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,03105898 0,05324707 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,03105898 0,05320973 ! arginine metabolic process GO:0006525 21 14 0,000 0,03105898 0,05317244 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,03105898 0,05313521 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,03105898 0,05309803 ! regulation of heart rate GO:0002027 25 14 0,000 0,03105898 0,05306089 ! fear response GO:0042596 34 14 0,000 0,03105898 0,05302381 ! organic alcohol transport GO:0015850 29 14 0,000 0,03105898 0,05298679 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,03105898 0,05294981 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,03105898 0,05291289 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,03105898 0,05287601 ! neutral amino acid transport GO:0015804 28 14 0,000 0,03105898 0,05283919 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,03105898 0,05280242 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,03105898 0,0527657 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,03105898 0,05272903 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,03105898 0,05269242 ! regulation of cellular pH GO:0030641 27 14 0,000 0,03105898 0,05265585 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,03105898 0,05261933 ! ribosome assembly GO:0042255 18 14 0,000 0,03105898 0,05258287 ! cerebellum development GO:0021549 23 14 0,000 0,03105898 0,05254645 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,03105898 0,05251009 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,03105898 0,05247377 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,03105898 0,05243751 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,03105898 0,0524013 ! NADP metabolic process GO:0006739 24 14 0,000 0,03105898 0,05236513 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,03105898 0,05232902 ! oxygen transport GO:0015671 22 14 0,000 0,03105898 0,05229296 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,03105898 0,05225694 ! male genitalia development GO:0030539 26 14 0,000 0,03105898 0,05222098 ! regulation of RNA stability GO:0043487 33 14 0,000 0,03105898 0,05218506 ! regulation of axon extension GO:0030516 43 14 0,000 0,03105898 0,05214919 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,03105898 0,05211338 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,03105898 0,05207761 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,03105898 0,05204189 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,03324066 0,05565931 ! lactation GO:0007595 30 15 0,000 0,03324066 0,05562119 ! reproductive cellular process GO:0048610 22 15 0,000 0,03324066 0,05558312 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,03324066 0,0555451 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,03324066 0,05550713 ! superoxide anion generation GO:0042554 22 15 0,000 0,03324066 0,05546922 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,03324066 0,05543136 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,03324066 0,05539354 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,03324066 0,05535578 ! copper ion transport GO:0006825 22 15 0,000 0,03324066 0,05531808 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,03324066 0,05528042 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,03324066 0,05524281 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,03324066 0,05520526 ! sulfate transport GO:0008272 27 15 0,000 0,03324066 0,05516775 ! response to cAMP GO:0051591 25 15 0,000 0,03324066 0,0551303 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,03324066 0,0550929 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,03324066 0,05505555 ! response to hexose stimulus GO:0009746 25 15 0,000 0,03324066 0,05501825 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,03324066 0,054981 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,03324066 0,0549438 ! vesicle coating GO:0006901 38 15 0,000 0,03324066 0,05490665 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,03324066 0,05486955 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,03324066 0,0548325 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,03324066 0,0547955 ! regulation of exocytosis GO:0017157 26 15 0,000 0,03324066 0,05475855 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,03324066 0,05472165 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,03324066 0,0546848 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,03324066 0,054648 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,03324066 0,05461125 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,03324066 0,05457455 ! regulation of vasodilation GO:0042312 27 15 0,000 0,03324066 0,0545379 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,03324066 0,0545013 ! histone deacetylation GO:0016575 24 15 0,000 0,03324066 0,05446475 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,03324066 0,05442824 ! water homeostasis GO:0030104 28 15 0,000 0,03324066 0,05439179 ! cofactor transport GO:0051181 30 15 0,000 0,03324066 0,05435538 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,03324066 0,05431902 ! muscle maintenance GO:0046716 26 15 0,000 0,03324066 0,05428271 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,03324066 0,05424645 ! intestinal absorption GO:0050892 31 15 0,000 0,03324066 0,05421024 ! dopamine metabolic process GO:0042417 35 15 0,000 0,03324066 0,05417407 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,03324066 0,05413796 ! heme biosynthetic process GO:0006783 33 15 0,000 0,03324066 0,05410189 ! cell killing GO:0001906 32 15 0,000 0,03324066 0,05406587 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,03324066 0,0540299 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,03324066 0,05399397 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,03324066 0,0539581 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,03324066 0,05392227 ! actin filament polymerization GO:0030041 27 15 0,000 0,03324066 0,05388649 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,03324066 0,05385075 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,0354175 0,05733926 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,0354175 0,05730129 ! positive regulation of cell size GO:0045793 29 16 0,000 0,0354175 0,05726336 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,0354175 0,05722549 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,0354175 0,05718767 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,0354175 0,0571499 ! bone remodeling GO:0046849 28 16 0,000 0,0354175 0,05711217 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0354175 0,0570745 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,0354175 0,05703688 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,0354175 0,0569993 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,0354175 0,05696178 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,0354175 0,0569243 ! startle response GO:0001964 28 16 0,000 0,0354175 0,05688688 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,0354175 0,0568495 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,0354175 0,05681217 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,0354175 0,0567749 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,0354175 0,05673767 ! protein polyubiquitination GO:0000209 41 16 0,000 0,0354175 0,05670049 ! glutamate metabolic process GO:0006536 25 16 0,000 0,0354175 0,05666335 ! pituitary gland development GO:0021983 30 16 0,000 0,0354175 0,05662627 ! response to osmotic stress GO:0006970 27 16 0,000 0,0354175 0,05658924 ! lysosomal transport GO:0007041 31 16 0,000 0,0354175 0,05655225 ! fructose metabolic process GO:0006000 25 16 0,000 0,0354175 0,05651531 ! L-amino acid transport GO:0015807 33 16 0,000 0,0354175 0,05647842 ! stem cell development GO:0048864 46 16 0,000 0,0354175 0,05644158 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,0354175 0,05640479 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,0354175 0,05636804 ! intermediate filament-based process GO:0045103 36 16 0,000 0,0354175 0,05633134 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,0354175 0,05629469 ! negative regulation of immune response GO:0050777 38 16 0,000 0,0354175 0,05625809 ! axon cargo transport GO:0008088 46 16 0,000 0,0354175 0,05622153 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,0354175 0,05618503 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,0354175 0,05614857 ! DNA replication initiation GO:0006270 28 16 0,000 0,0354175 0,05611215 ! neuron recognition GO:0008038 40 16 0,000 0,0354175 0,05607579 ! mRNA splice site selection GO:0006376 44 16 0,000 0,0354175 0,05603947 ! tissue regeneration GO:0042246 27 16 0,000 0,0354175 0,0560032 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,0354175 0,05596697 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,0354175 0,0559308 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,0354175 0,05589467 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,0354175 0,05585858 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,0354175 0,05582254 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,0354175 0,05578655 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,0354175 0,05575061 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,0354175 0,05571471 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,0354175 0,05567886 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,0354175 0,05564305 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,0354175 0,05560729 ! peptide hormone processing GO:0016486 27 16 0,000 0,0354175 0,05557157 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,03758949 0,05894167 ! metencephalon development GO:0022037 32 17 0,000 0,03758949 0,05890386 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,03758949 0,0588661 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,03758949 0,05882839 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,03758949 0,05879073 ! signal complex assembly GO:0007172 47 17 0,000 0,03758949 0,05875312 ! filopodium assembly GO:0046847 42 17 0,000 0,03758949 0,05871555 ! endothelial cell migration GO:0043542 31 17 0,000 0,03758949 0,05867803 ! gene silencing by RNA GO:0031047 38 17 0,000 0,03758949 0,05864056 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,03758949 0,05860314 ! glial cell development GO:0021782 28 17 0,000 0,03758949 0,05856577 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,03758949 0,05852844 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,03758949 0,05849116 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,03758949 0,05845393 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,03758949 0,05841674 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,03758949 0,05837961 ! myoblast differentiation GO:0045445 50 17 0,000 0,03758949 0,05834252 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,03758949 0,05830547 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,03758949 0,05826848 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,03758949 0,05823153 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,03758949 0,05819463 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,03758949 0,05815777 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,03758949 0,05812096 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,03758949 0,0580842 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,03758949 0,05804749 ! membrane budding GO:0006900 42 17 0,000 0,03758949 0,05801082 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,03758949 0,05797419 ! regulation of protein binding GO:0043393 33 17 0,000 0,03758949 0,05793762 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,03758949 0,05790109 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,03758949 0,0578646 ! genitalia development GO:0048806 32 17 0,000 0,03758949 0,05782816 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,03758949 0,05779177 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,03758949 0,05775542 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,03758949 0,05771912 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,03758949 0,05768287 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,03758949 0,05764666 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,03758949 0,05761049 ! steroid catabolic process GO:0006706 34 17 0,000 0,03758949 0,05757437 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,03758949 0,0575383 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,03758949 0,05750227 ! gas transport GO:0015669 26 17 0,000 0,03758949 0,05746628 ! organic cation transport GO:0015695 32 17 0,000 0,03758949 0,05743035 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,03758949 0,05739445 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,03758949 0,0573586 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,03758949 0,0573228 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,03975665 0,06058983 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,03975665 0,06055206 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,03975665 0,06051433 ! limbic system development GO:0021761 40 18 0,000 0,03975665 0,06047665 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,03975665 0,06043902 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,03975665 0,06040143 ! adult walking behavior GO:0007628 36 18 0,000 0,03975665 0,06036389 ! patterning of blood vessels GO:0001569 43 18 0,000 0,03975665 0,0603264 ! heart looping GO:0001947 34 18 0,000 0,03975665 0,06028895 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,03975665 0,06025155 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,03975665 0,0602142 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,03975665 0,06017689 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,03975665 0,06013963 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,03975665 0,06010242 ! glycine metabolic process GO:0006544 30 18 0,000 0,03975665 0,06006525 ! glutamine metabolic process GO:0006541 29 18 0,000 0,03975665 0,06002812 ! response to retinoic acid GO:0032526 31 18 0,000 0,03975665 0,05999105 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,03975665 0,05995402 ! DNA integration GO:0015074 32 18 0,000 0,03975665 0,05991703 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,03975665 0,05988009 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,03975665 0,05984319 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,03975665 0,05980635 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,03975665 0,05976954 ! neural crest cell migration GO:0001755 41 18 0,000 0,03975665 0,05973278 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,03975665 0,05969607 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,03975665 0,0596594 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,03975665 0,05962278 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,03975665 0,0595862 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,03975665 0,05954967 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,03975665 0,05951318 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,03975665 0,05947673 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,03975665 0,05944033 ! detection of bacterium GO:0016045 22 18 0,000 0,03975665 0,05940398 ! nerve development GO:0021675 34 18 0,000 0,03975665 0,05936767 ! defense response to virus GO:0051607 43 18 0,000 0,03975665 0,0593314 ! microspike assembly GO:0030035 46 18 0,000 0,03975665 0,05929518 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,03975665 0,059259 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,03975665 0,05922287 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,041919 0,06240592 ! positive regulation of translation GO:0045727 31 19 0,000 0,041919 0,06236791 ! negative regulation of defense response GO:0031348 27 19 0,000 0,041919 0,06232995 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,041919 0,06229204 ! neuron maturation GO:0042551 46 19 0,000 0,041919 0,06225417 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,041919 0,06221635 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,041919 0,06217858 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,041919 0,06214085 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,041919 0,06210316 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,041919 0,06206552 ! inositol metabolic process GO:0006020 33 19 0,000 0,041919 0,06202793 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,041919 0,06199038 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,041919 0,06195288 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,041919 0,06191543 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,041919 0,06187801 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,041919 0,06184065 ! pigmentation during development GO:0048066 42 19 0,000 0,041919 0,06180333 ! response to vitamin A GO:0033189 32 19 0,000 0,041919 0,06176605 ! heme metabolic process GO:0042168 40 19 0,000 0,041919 0,06172882 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,041919 0,06169163 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,041919 0,06165449 ! response to fungus GO:0009620 26 19 0,000 0,041919 0,0616174 ! peptide cross-linking GO:0018149 39 19 0,000 0,041919 0,06158034 ! protein export from nucleus GO:0006611 40 19 0,000 0,041919 0,06154334 ! heart process GO:0003015 32 19 0,000 0,041919 0,06150637 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,041919 0,06146946 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,041919 0,06143258 ! visual learning GO:0008542 38 19 0,000 0,041919 0,06139575 ! cellular pigmentation GO:0033059 37 19 0,000 0,041919 0,06135897 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,041919 0,06132222 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,041919 0,06128553 ! vitamin transport GO:0051180 31 19 0,000 0,041919 0,06124887 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,041919 0,06121226 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,041919 0,0611757 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,041919 0,06113917 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,041919 0,06110269 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,041919 0,06106626 ! cilium assembly GO:0042384 38 19 0,000 0,041919 0,06102987 ! peptide hormone secretion GO:0030072 32 19 0,000 0,041919 0,06099352 ! protein secretion GO:0009306 45 20 0,000 0,04407653 0,06409463 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,04407653 0,0640565 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,04407653 0,06401842 ! positive regulation of ossification GO:0045778 50 20 0,000 0,04407653 0,06398038 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,04407653 0,06394238 ! skin development GO:0043588 42 20 0,000 0,04407653 0,06390444 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,04407653 0,06386653 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,04407653 0,06382868 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,04407653 0,06379086 ! response to vitamin GO:0033273 36 20 0,000 0,04407653 0,06375309 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,04407653 0,06371537 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,04407653 0,06367769 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,04407653 0,06364006 ! bile acid metabolic process GO:0008206 34 20 0,000 0,04407653 0,06360247 ! response to alkaloid GO:0043279 38 20 0,000 0,04407653 0,06356492 ! retinoid metabolic process GO:0001523 34 20 0,000 0,04407653 0,06352742 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,04407653 0,06348996 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,04407653 0,06345255 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,04407653 0,06341518 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,04407653 0,06337785 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,04407653 0,06334057 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,04407653 0,06330334 ! body fluid secretion GO:0007589 33 20 0,000 0,04407653 0,06326614 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,04407653 0,06322899 ! peptide secretion GO:0002790 38 20 0,000 0,04407653 0,06319189 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,04407653 0,06315482 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,04407653 0,0631178 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,04407653 0,06308083 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,04407653 0,0630439 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,04407653 0,06300701 ! cell-cell junction organization GO:0045216 43 20 0,000 0,04407653 0,06297016 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,04407653 0,06293336 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,04407653 0,0628966 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,04407653 0,06285988 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,04407653 0,06282321 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,04407653 0,06278657 ! regulation of glucose import GO:0046324 30 20 0,000 0,04407653 0,06274999 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,04407653 0,06271344 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,04407653 0,06267694 ! negative regulation of translation GO:0017148 32 20 0,000 0,04407653 0,06264047 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,04407653 0,06260406 ! regulation of cell killing GO:0031341 46 21 0,000 0,04622927 0,06562354 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,04622927 0,06558543 ! hormone secretion GO:0046879 39 21 0,000 0,04622927 0,06554737 ! cAMP metabolic process GO:0046058 41 21 0,000 0,04622927 0,06550935 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,04622927 0,06547137 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,04622927 0,06543344 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,04622927 0,06539555 ! ovarian follicle development GO:0001541 39 21 0,000 0,04622927 0,06535771 ! smooth muscle contraction GO:0006939 48 21 0,000 0,04622927 0,0653199 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,04622927 0,06528215 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,04622927 0,06524443 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,04622927 0,06520676 ! plasma membrane fusion GO:0045026 33 21 0,000 0,04622927 0,06516914 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,04622927 0,06513155 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,04622927 0,06509401 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,04622927 0,06505652 ! sensory perception of pain GO:0019233 33 21 0,000 0,04622927 0,06501906 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,04622927 0,06498165 ! diencephalon development GO:0021536 36 21 0,000 0,04622927 0,06494429 ! collagen fibril organization GO:0030199 62 21 0,000 0,04622927 0,06490696 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,04622927 0,06486968 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,04622927 0,06483244 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,04622927 0,06479525 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,04622927 0,06475809 ! collagen catabolic process GO:0030574 29 21 0,000 0,04622927 0,06472098 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,04622927 0,06468391 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,04622927 0,06464689 ! sperm-egg recognition GO:0035036 23 21 0,000 0,04622927 0,06460991 ! actin filament-based movement GO:0030048 47 21 0,000 0,04622927 0,06457296 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,04622927 0,06453607 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,04837722 0,06749604 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,04837722 0,06745751 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,04837722 0,06741903 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,04837722 0,06738059 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,04837722 0,0673422 ! microtubule-based transport GO:0010970 59 22 0,000 0,04837722 0,06730385 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,04837722 0,06726554 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,04837722 0,06722728 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,04837722 0,06718906 ! cellular response to starvation GO:0009267 37 22 0,000 0,04837722 0,06715089 ! vacuolar transport GO:0007034 41 22 0,000 0,04837722 0,06711275 ! fucose metabolic process GO:0006004 44 22 0,000 0,04837722 0,06707466 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,04837722 0,06703662 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,04837722 0,06699862 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,04837722 0,06696066 ! ureteric bud development GO:0001657 50 22 0,000 0,04837722 0,06692274 ! stem cell differentiation GO:0048863 57 22 0,000 0,04837722 0,06688487 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,04837722 0,06684704 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,04837722 0,06680925 ! cytolysis GO:0019835 27 22 0,000 0,04837722 0,0667715 ! renal system process GO:0003014 42 22 0,000 0,04837722 0,0667338 ! vasodilation GO:0042311 40 22 0,000 0,04837722 0,06669614 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,04837722 0,06665852 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,04837722 0,06662095 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,04837722 0,06658341 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,04837722 0,06654592 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,04837722 0,06650847 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,04837722 0,06647107 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,04837722 0,0664337 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,04837722 0,06639638 ! sarcomere organization GO:0045214 32 22 0,000 0,04837722 0,0663591 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,04837722 0,06632186 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,04837722 0,06628467 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,04837722 0,06624751 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,04837722 0,0662104 ! gut development GO:0048565 44 22 0,000 0,04837722 0,06617333 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,04837722 0,06613629 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,04837722 0,06609931 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,04837722 0,06606236 ! protein stabilization GO:0050821 41 22 0,000 0,04837722 0,06602545 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,0505204 0,06891197 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,0505204 0,06887351 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,0505204 0,0688351 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,0505204 0,06879673 ! gluconeogenesis GO:0006094 38 23 0,000 0,0505204 0,0687584 ! glycerol metabolic process GO:0006071 40 23 0,000 0,0505204 0,06872012 ! viral genome replication GO:0019079 44 23 0,000 0,0505204 0,06868188 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,0505204 0,06864368 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,0505204 0,06860552 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,0505204 0,06856741 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,0505204 0,06852934 ! regeneration GO:0031099 42 23 0,000 0,0505204 0,06849131 ! axis specification GO:0009798 43 23 0,000 0,0505204 0,06845332 ! visual behavior GO:0007632 46 23 0,000 0,0505204 0,06841537 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,0505204 0,06837747 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,0505204 0,06833961 ! response to ethanol GO:0045471 47 23 0,000 0,0505204 0,06830179 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,0505204 0,06826401 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,0505204 0,06822628 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,0505204 0,06818858 ! peroxisome organization GO:0007031 43 23 0,000 0,0505204 0,06815093 ! lysosome organization GO:0007040 47 23 0,000 0,0505204 0,06811332 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,0505204 0,06807575 ! vesicle targeting GO:0006903 49 23 0,000 0,0505204 0,06803822 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,0505204 0,06800073 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,0505204 0,06796329 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,0505204 0,06792588 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,0505204 0,06788852 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,0505204 0,0678512 ! DNA modification GO:0006304 36 23 0,000 0,0505204 0,06781392 ! fatty acid transport GO:0015908 47 23 0,000 0,0505204 0,06777668 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,0505204 0,06773948 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,0505204 0,06770232 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,0505204 0,0676652 ! hormone transport GO:0009914 41 23 0,000 0,0505204 0,06762813 ! cell-cell recognition GO:0009988 28 23 0,000 0,0505204 0,06759109 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,0505204 0,0675541 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,0505204 0,06751714 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,0505204 0,06748023 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,05265881 0,07029807 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,05265881 0,07025967 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,05265881 0,07022132 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,05265881 0,07018301 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,05265881 0,07014474 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,05265881 0,07010652 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,05265881 0,07006833 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,05265881 0,07003019 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,05265881 0,06999209 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,05265881 0,06995403 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,05265881 0,06991601 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,05265881 0,06987803 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,05265881 0,0698401 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,05265881 0,0698022 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,05265881 0,06976435 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,05265881 0,06972654 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,05265881 0,06968877 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,05265881 0,06965103 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,05265881 0,06961335 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,05265881 0,0695757 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,05265881 0,06953809 ! membrane depolarization GO:0051899 45 24 0,000 0,05265881 0,06950052 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,05265881 0,06946299 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,05265881 0,06942551 ! platelet activation GO:0030168 41 24 0,000 0,05265881 0,06938806 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,05265881 0,06935065 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,05265881 0,06931329 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,05265881 0,06927596 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,05265881 0,06923868 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,05265881 0,06920143 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,05265881 0,06916423 ! regulation of amine transport GO:0051952 41 24 0,000 0,05265881 0,06912706 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,05265881 0,06908994 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,05479246 0,07185076 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,05479246 0,07181222 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,05479246 0,07177371 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,05479246 0,07173525 ! phototransduction GO:0007602 37 25 0,000 0,05479246 0,07169682 ! keratinization GO:0031424 37 25 0,000 0,05479246 0,07165844 ! vasculogenesis GO:0001570 49 25 0,000 0,05479246 0,0716201 ! vacuole organization GO:0007033 49 25 0,000 0,05479246 0,0715818 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,05479246 0,07154354 ! receptor metabolic process GO:0043112 53 25 0,000 0,05479246 0,07150533 ! chromosome condensation GO:0030261 48 25 0,000 0,05479246 0,07146715 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,05479246 0,07142901 ! regulation of behavior GO:0050795 48 25 0,000 0,05479246 0,07139092 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,05479246 0,07135286 ! interaction with host GO:0051701 66 25 0,000 0,05479246 0,07131485 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,05479246 0,07127688 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,05479246 0,07123894 ! immunoglobulin production GO:0002377 62 25 0,000 0,05479246 0,07120105 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,05479246 0,0711632 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,05479246 0,07112538 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,05479246 0,07108761 ! liver development GO:0001889 55 25 0,000 0,05479246 0,07104988 ! protein tetramerization GO:0051262 57 25 0,000 0,05479246 0,07101219 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,05692136 0,07373218 ! initiation of viral infection GO:0019059 60 26 0,000 0,05692136 0,0736931 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,05692136 0,07365407 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,05692136 0,07361508 ! molting cycle process GO:0022404 52 26 0,000 0,05692136 0,07357613 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,05692136 0,07353722 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,05692136 0,07349836 GO:0006479|protein amino acid methylation, ! spinal cord development GO:0021510 54 26 0,000 0,05692136 0,07345953 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,05692136 0,07342074 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,05692136 0,073382 ! digestive system process GO:0022600 49 26 0,000 0,05692136 0,0733433 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,05692136 0,07330463 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,05692136 0,07326601 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,05692136 0,07322743 ! osteoblast differentiation GO:0001649 63 26 0,000 0,05692136 0,07318889 ! neural crest cell development GO:0014032 59 26 0,000 0,05692136 0,07315039 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,05692136 0,07311193 ! negative regulation of cell development GO:0010721 83 26 0,000 0,05692136 0,07307351 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,05692136 0,07303513 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,05692136 0,07299679 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,05692136 0,07295849 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,05692136 0,07292024 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,05692136 0,07288202 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,05692136 0,07284384 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,05692136 0,0728057 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,05692136 0,0727676 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,05692136 0,07272954 ! telomere organization GO:0032200 46 26 0,000 0,05692136 0,07269153 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,05692136 0,07265355 ! neural tube closure GO:0001843 58 26 0,000 0,05692136 0,07261561 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,05692136 0,07257771 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,05692136 0,07253985 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,05692136 0,07250203 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,05904553 0,07516844 ! embryonic pattern specification GO:0009880 49 27 0,000 0,05904553 0,07512929 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,05904553 0,07509018 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,05904553 0,07505111 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,05904553 0,07501208 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,05904553 0,0749731 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,05904553 0,07493415 ! iron ion transport GO:0006826 65 27 0,000 0,05904553 0,07489524 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,05904553 0,07485638 ! superoxide metabolic process GO:0006801 41 27 0,000 0,05904553 0,07481755 ! tube lumen formation GO:0035148 59 27 0,000 0,05904553 0,07477876 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,05904553 0,07474002 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,05904553 0,07470131 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,05904553 0,07466265 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,05904553 0,07462402 ! response to starvation GO:0042594 47 27 0,000 0,05904553 0,07458544 ! response to toxin GO:0009636 49 27 0,000 0,05904553 0,07454689 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,05904553 0,07450839 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,05904553 0,07446992 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,05904553 0,0744315 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,05904553 0,07439311 ! leukocyte proliferation GO:0070661 59 27 0,000 0,05904553 0,07435476 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,06116498 0,07698405 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,06116498 0,07694441 ! vesicle docking GO:0048278 55 28 0,000 0,06116498 0,07690481 ! circadian rhythm GO:0007623 56 28 0,000 0,06116498 0,07686525 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,06116498 0,07682573 ! fat cell differentiation GO:0045444 57 28 0,000 0,06116498 0,07678625 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,06116498 0,07674681 ! sperm motility GO:0030317 37 28 0,000 0,06116498 0,07670741 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,06116498 0,07666806 ! base-excision repair GO:0006284 41 28 0,000 0,06116498 0,07662874 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,06116498 0,07658946 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,06116498 0,07655023 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,06116498 0,07651103 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,06116498 0,07647187 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,06116498 0,07643276 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,06116498 0,07639368 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,06116498 0,07635465 ! glutathione metabolic process GO:0006749 42 28 0,000 0,06116498 0,07631565 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,06116498 0,07627669 ! lipid oxidation GO:0034440 48 28 0,000 0,06116498 0,07623778 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,06116498 0,0761989 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,06116498 0,07616006 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,06327971 0,0787531 ! translational initiation GO:0006413 66 29 0,000 0,06327971 0,078713 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,06327971 0,07867294 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,06327971 0,07863293 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,06327971 0,07859295 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,06327971 0,07855301 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,06327971 0,07851312 ! primary neural tube formation GO:0014020 61 29 0,000 0,06327971 0,07847327 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,06327971 0,07843345 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,06327971 0,07839368 ! synaptogenesis GO:0007416 46 29 0,000 0,06327971 0,07835394 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,06327971 0,07831425 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,06327971 0,0782746 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,06327971 0,07823499 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,06327971 0,07819541 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,06538974 0,08076195 ! phenol metabolic process GO:0018958 56 30 0,000 0,06538974 0,08072114 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,06538974 0,08068037 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,06538974 0,08063964 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,06538974 0,08059896 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,06538974 0,08055831 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,06538974 0,08051771 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,06538974 0,08047714 ! acute-phase response GO:0006953 50 30 0,000 0,06538974 0,08043662 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,06538974 0,08039614 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,06538974 0,0803557 ! myofibril assembly GO:0030239 50 30 0,000 0,06538974 0,0803153 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,06538974 0,08027494 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,06538974 0,08023462 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,06538974 0,08019434 ! cell fate determination GO:0001709 64 30 0,000 0,06538974 0,0801541 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,06538974 0,08011391 ! phospholipid transport GO:0015914 65 30 0,000 0,06538974 0,08007375 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,06538974 0,08003363 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,06538974 0,07999355 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,06538974 0,07995352 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,06538974 0,07991352 GO:0043433|negative regulation of transcription factor activity, ! regulation of coagulation GO:0050818 52 30 0,000 0,06538974 0,07987356 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,06749507 0,08240403 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,06749507 0,08236287 GO:0009799|determination of symmetry, ! amino sugar metabolic process GO:0006040 41 31 0,000 0,06749507 0,08232175 ! regulation of innate immune response GO:0045088 57 31 0,000 0,06749507 0,08228067 ! ovulation cycle process GO:0022602 55 31 0,000 0,06749507 0,08223963 ! peptide transport GO:0015833 60 31 0,000 0,06749507 0,08219863 ! male gonad development GO:0008584 56 31 0,000 0,06749507 0,08215768 ! iron ion homeostasis GO:0055072 60 31 0,000 0,06749507 0,08211676 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,06749507 0,08207589 ! detection of light stimulus GO:0009583 44 31 0,000 0,06749507 0,08203505 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,06749507 0,08199426 ! natural killer cell activation GO:0030101 50 31 0,000 0,06749507 0,08195351 ! cofactor catabolic process GO:0051187 54 31 0,000 0,06749507 0,0819128 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,06749507 0,08187212 ! eye morphogenesis GO:0048592 65 31 0,000 0,06749507 0,08183149 ! response to heat GO:0009408 54 31 0,000 0,06749507 0,0817909 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,06749507 0,08175035 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,06959572 0,0842529 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,06959572 0,08421117 ! collagen metabolic process GO:0032963 49 32 0,000 0,06959572 0,08416948 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,06959572 0,08412783 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,06959572 0,08408623 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,06959572 0,08404466 ! metanephros development GO:0001656 81 32 0,000 0,06959572 0,08400314 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,06959572 0,08396165 ! muscle cell development GO:0055001 52 32 0,000 0,06959572 0,08392021 ! mesoderm formation GO:0001707 73 32 0,000 0,06959572 0,08387881 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,06959572 0,08383745 ! ovulation cycle GO:0042698 57 32 0,000 0,06959572 0,08379613 ! BMP signaling pathway GO:0030509 71 32 0,000 0,06959572 0,08375485 ! hindbrain development GO:0030902 65 32 0,000 0,06959572 0,08371361 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,06959572 0,08367242 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,06959572 0,08363126 ! gene silencing GO:0016458 71 32 0,000 0,06959572 0,08359014 ! regulation of pH GO:0006885 56 33 0,000 0,0716917 0,08606527 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,0716917 0,086023 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,0716917 0,08598077 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,0716917 0,08593858 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,0716917 0,08589643 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,0716917 0,08585432 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,0716917 0,08581226 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,0716917 0,08577024 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,0716917 0,08572825 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,0716917 0,08568631 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,0716917 0,08564441 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,0716917 0,08560255 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,0716917 0,08556073 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,07378301 0,08801362 ! glial cell differentiation GO:0010001 67 34 0,000 0,07378301 0,08797067 ! post-embryonic development GO:0009791 76 34 0,000 0,07378301 0,08792776 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,07378301 0,08788489 ! cholesterol transport GO:0030301 62 34 0,000 0,07378301 0,08784206 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,07378301 0,08779927 ! spliceosome assembly GO:0000245 75 34 0,000 0,07378301 0,08775652 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,07378301 0,08771382 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,07378301 0,08767116 ! formation of primary germ layer GO:0001704 76 34 0,000 0,07378301 0,08762854 ! cell fate specification GO:0001708 56 34 0,000 0,07378301 0,08758596 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,07378301 0,08754342 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,07378301 0,08750092 ! adult locomotory behavior GO:0008344 62 34 0,000 0,07378301 0,08745847 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,07378301 0,08741605 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,07586968 0,0898447 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,07586968 0,08980117 ! negative regulation of secretion GO:0051048 68 35 0,000 0,07586968 0,08975768 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,07586968 0,08971424 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,07586968 0,08967084 ! membrane docking GO:0022406 69 35 0,000 0,07586968 0,08962747 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,07586968 0,08958415 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,07586968 0,08954088 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,07586968 0,08949764 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,07586968 0,08945445 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,07586968 0,0894113 ! ceramide metabolic process GO:0006672 72 35 0,000 0,07586968 0,08936819 ! sterol transport GO:0015918 63 35 0,000 0,07586968 0,08932512 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,07586968 0,08928209 ! placenta development GO:0001890 53 35 0,000 0,07586968 0,0892391 ! vesicle localization GO:0051648 70 35 0,000 0,07586968 0,08919616 ! regulation of muscle development GO:0048634 82 36 0,000 0,07795169 0,0915998 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,07795169 0,09155576 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,07795169 0,09151177 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,07795169 0,09146781 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,07795169 0,0914239 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,07795169 0,09138003 ! positive regulation of cell development GO:0010720 85 36 0,000 0,07795169 0,09133621 ! protein targeting to membrane GO:0006612 75 36 0,000 0,07795169 0,09129242 ! regulation of proteolysis GO:0030162 77 36 0,000 0,07795169 0,09124868 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,07795169 0,09120498 ! aerobic respiration GO:0009060 56 36 0,000 0,07795169 0,09116132 ! cytokine production GO:0001816 68 36 0,000 0,07795169 0,0911177 ! embryonic organ development GO:0048568 67 36 0,000 0,07795169 0,09107412 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,07795169 0,09103059 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,07795169 0,09098709 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,08002908 0,09336726 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,08002908 0,0933227 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,08002908 0,09327817 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,08002908 0,09323369 ! sister chromatid segregation GO:0000819 65 37 0,000 0,08002908 0,09318925 ! odontogenesis GO:0042476 74 37 0,000 0,08002908 0,09314485 ! actomyosin structure organization GO:0031032 68 37 0,000 0,08002908 0,0931005 ! tissue remodeling GO:0048771 78 37 0,000 0,08002908 0,09305619 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,08002908 0,09301192 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,08210185 0,09537556 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,08210185 0,09533023 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,08210185 0,09528495 ! organic anion transport GO:0015711 82 38 0,000 0,08210185 0,0952397 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,08210185 0,0951945 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,08210185 0,09514934 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,08210185 0,09510423 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,08210185 0,09505915 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,08210185 0,09501412 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,08210185 0,09496913 ! regulation of protein stability GO:0031647 77 38 0,000 0,08210185 0,09492419 ! spermatid development GO:0007286 69 38 0,000 0,08210185 0,09487929 ! pigment metabolic process GO:0042440 87 38 0,000 0,08210185 0,09483443 ! neural tube formation GO:0001841 79 38 0,000 0,08210185 0,09478961 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,08417 0,09713146 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,08417 0,0970856 ! negative regulation of binding GO:0051100 71 39 0,000 0,08417 0,09703979 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,08417 0,09699401 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,08417 0,09694828 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,08417 0,0969026 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,08417 0,09685695 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,08417 0,09681135 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,08417 0,09676579 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,08417 0,09672028 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,08623355 0,09904493 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,08623355 0,09899839 ! nucleus organization GO:0006997 73 40 0,000 0,08623355 0,09895189 ! lipid homeostasis GO:0055088 75 40 0,000 0,08623355 0,09890543 ! mismatch repair GO:0006298 58 40 0,000 0,08623355 0,09885902 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,08623355 0,09881265 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,08623355 0,09876632 ! RNA export from nucleus GO:0006405 61 41 0,000 0,08829251 0,10107714 ! mRNA catabolic process GO:0006402 79 41 0,000 0,08829251 0,10102979 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,08829251 0,10098249 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,08829251 0,10093524 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,08829251 0,10088803 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,08829251 0,10084086 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,08829251 0,10079374 ! gliogenesis GO:0042063 91 41 0,000 0,08829251 0,10074666 ! feeding behavior GO:0007631 69 41 0,000 0,08829251 0,10069963 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,08829251 0,10065264 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,08829251 0,10060569 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,08829251 0,10055879 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,08829251 0,10051193 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,08829251 0,10046512 ! RNA modification GO:0009451 64 41 0,000 0,08829251 0,10041835 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,09034689 0,10270705 ! ear morphogenesis GO:0042471 64 42 0,000 0,09034689 0,10265928 ! organic ether metabolic process GO:0018904 59 42 0,000 0,09034689 0,10261155 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,09034689 0,10256387 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,09034689 0,10251623 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,09034689 0,10246864 ! regulation of protein secretion GO:0050708 77 42 0,000 0,09034689 0,10242109 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,09034689 0,10237359 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,09034689 0,10232613 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,0923967 0,10459923 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,0923967 0,10455078 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,0923967 0,10450238 ! regulation of tube size GO:0035150 76 43 0,000 0,0923967 0,10445402 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,0923967 0,1044057 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,0923967 0,10435743 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,0923967 0,10430921 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,0923967 0,10426103 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,0923967 0,1042129 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,0923967 0,1041648 ! ion transmembrane transport GO:0034220 79 43 0,000 0,0923967 0,10411676 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,0923967 0,10406876 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,09444194 0,10632335 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,09444194 0,10627437 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,09444194 0,10622544 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,09444194 0,10617656 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,09444194 0,10612772 ! striated muscle contraction GO:0006941 85 44 0,000 0,09444194 0,10607893 ! phagocytosis GO:0006909 105 44 0,000 0,09444194 0,10603018 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,09444194 0,10598147 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,09648264 0,1082218 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,09648264 0,10817214 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,09648264 0,10812251 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,09648264 0,10807294 ! biopolymer methylation GO:0043414 91 45 0,000 0,09648264 0,10802341 ! B cell differentiation GO:0030183 124 45 0,000 0,09648264 0,10797393 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,09648264 0,10792449 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,09648264 0,10787509 ! polyol metabolic process GO:0019751 77 45 0,000 0,09648264 0,10782575 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,09851879 0,11005094 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,09851879 0,11000064 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,09851879 0,10995039 ! leukocyte migration GO:0050900 75 46 0,000 0,09851879 0,10990018 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,09851879 0,10985002 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,09851879 0,10979991 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,09851879 0,10974984 ! pigmentation GO:0043473 103 46 0,000 0,09851879 0,10969982 ! neural tube development GO:0021915 91 47 0,000 0,10055041 0,111911 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,10055041 0,11186004 ! positive regulation of defense response GO:0031349 88 48 0,000 0,10257751 0,1140632 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,10257751 0,11401131 ! mitochondrial transport GO:0006839 94 48 0,000 0,10257751 0,11395946 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,10257751 0,11390766 ! cellular component disassembly GO:0022411 89 48 0,000 0,10257751 0,11385591 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,10257751 0,11380421 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,10257751 0,11375255 ! male sex differentiation GO:0046661 93 48 0,000 0,10257751 0,11370093 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,10257751 0,11364937 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,10257751 0,11359785 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,10257751 0,11354638 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,10257751 0,11349495 ! methylation GO:0032259 97 48 0,000 0,10257751 0,11344358 ! response to calcium ion GO:0051592 94 49 0,000 0,1046001 0,11562807 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,1046001 0,11557578 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,1046001 0,11552353 ! JNK cascade GO:0007254 106 49 0,000 0,1046001 0,11547133 ! regulation of ion transport GO:0043269 86 50 0,000 0,10661819 0,11764599 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,10661819 0,11759288 ! endocrine system development GO:0035270 109 50 0,000 0,10661819 0,11753981 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,10661819 0,1174868 ! activation of caspase activity GO:0006919 95 50 0,000 0,10661819 0,11743383 ! regulation of ossification GO:0030278 123 50 0,000 0,10661819 0,11738091 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,10661819 0,11732803 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,10661819 0,1172752 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,10661819 0,11722243 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,10661819 0,11716969 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,10661819 0,11711701 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,10863178 0,11927526 ! viral infectious cycle GO:0019058 104 51 0,000 0,10863178 0,11922167 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,10863178 0,11916814 ! peptide metabolic process GO:0006518 80 51 0,000 0,10863178 0,11911465 ! response to temperature stimulus GO:0009266 84 51 0,000 0,10863178 0,11906121 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,10863178 0,11900782 ! Notch signaling pathway GO:0007219 111 52 0,000 0,11064089 0,12115451 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,11064089 0,12110023 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,11064089 0,12104599 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,11064089 0,12099181 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,11064089 0,12093768 ! excretion GO:0007588 87 52 0,000 0,11064089 0,12088359 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,11064089 0,12082955 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,11064089 0,12077556 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,11064089 0,12072162 ! amino acid activation GO:0043038 98 52 0,000 0,11064089 0,12066773 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,11264554 0,12279922 ! positive regulation of growth GO:0045927 96 53 0,000 0,11264554 0,12274444 ! inner ear development GO:0048839 89 53 0,000 0,11264554 0,12268972 ! chromatin remodeling GO:0006338 122 53 0,000 0,11264554 0,12263505 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,11264554 0,12258042 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,11264554 0,12252584 ! vesicle organization GO:0016050 127 53 0,000 0,11264554 0,12247132 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,11264554 0,12241683 ! cartilage development GO:0051216 99 53 0,000 0,11264554 0,1223624 ! regulation of translational initiation GO:0006446 87 54 0,000 0,11464572 0,12447977 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,11464572 0,12442447 ! neuromuscular process GO:0050905 107 54 0,000 0,11464572 0,12436922 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,11464572 0,12431402 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,11464572 0,12425887 ! membrane fusion GO:0006944 122 54 0,000 0,11464572 0,12420376 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,11464572 0,12414871 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,11464572 0,1240937 ! regulation of cell shape GO:0008360 142 54 0,000 0,11464572 0,12403874 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,11464572 0,12398383 ! RNA catabolic process GO:0006401 103 55 0,000 0,11664144 0,1260863 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,11664144 0,12603054 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,11664144 0,12597482 ! cell recognition GO:0008037 98 55 0,000 0,11664144 0,12591915 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,11664144 0,12586353 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,11664144 0,12580797 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,11664144 0,12575245 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,11863273 0,12784285 ! RNA elongation GO:0006354 90 56 0,000 0,11863273 0,12778649 ! chloride transport GO:0006821 102 57 0,000 0,12061958 0,12986938 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,12061958 0,12981217 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,12061958 0,12975501 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 105 57 0,000 0,12061958 0,1296979 ! regulation of actin filament length GO:0030832 118 58 0,000 0,12260201 0,13177154 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,12260201 0,13171359 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,12260201 0,13165569 ! gastrulation GO:0007369 122 58 0,000 0,12260201 0,13159785 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,12260201 0,13154005 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,12260201 0,13148231 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,12260201 0,13142462 ! nuclear export GO:0051168 110 59 0,000 0,12458002 0,1334864 ! establishment of organelle localization GO:0051656 122 59 0,000 0,12458002 0,13342788 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,12655363 0,13548226 ! DNA catabolic process GO:0006308 94 60 0,000 0,12655363 0,13542292 ! regulation of endocytosis GO:0030100 104 60 0,000 0,12655363 0,13536363 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,12655363 0,13530439 ! adult behavior GO:0030534 104 60 0,000 0,12655363 0,1352452 ! kidney development GO:0001822 133 60 0,000 0,12655363 0,13518606 ! positive regulation of secretion GO:0051047 110 61 0,000 0,12852285 0,1372296 ! regulation of cellular component size GO:0032535 125 61 0,000 0,12852285 0,13716965 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,12852285 0,13710975 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,12852285 0,1370499 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,12852285 0,13699011 ! regulation of heart contraction GO:0008016 123 61 0,000 0,12852285 0,13693036 ! camera-type eye development GO:0043010 126 61 0,000 0,12852285 0,13687067 ! proton transport GO:0015992 117 61 0,000 0,12852285 0,13681103 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,12852285 0,13675145 ! viral reproductive process GO:0022415 132 62 0,000 0,13048768 0,13878163 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,13048768 0,13872124 ! tRNA processing GO:0008033 102 62 0,000 0,13048768 0,1386609 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,13048768 0,13860061 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,13244814 0,14062182 ! regulation of mitosis GO:0007088 112 63 0,000 0,13244814 0,14056073 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,13244814 0,1404997 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,13244814 0,14043872 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,13244814 0,14037779 ! hydrogen transport GO:0006818 121 64 0,000 0,13440423 0,14238922 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,13440423 0,1423275 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,13635597 0,14433173 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,13635597 0,14426923 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,13635597 0,14420677 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,13635597 0,14414437 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,13635597 0,14408202 ! ear development GO:0043583 114 66 0,000 0,13830336 0,14607658 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,13830336 0,14601345 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,13830336 0,14595038 ! activation of MAPK activity GO:0000187 124 67 0,000 0,14024642 0,14793696 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,14024642 0,14787311 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,14024642 0,14780932 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,14024642 0,14774558 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,14024642 0,1476819 ! secondary metabolic process GO:0019748 125 67 0,000 0,14024642 0,14761827 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,14024642 0,1475547 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,14218515 0,14953006 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,14218515 0,14946571 ! extracellular matrix organization GO:0030198 146 68 0,000 0,14218515 0,14940143 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,14218515 0,1493372 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,14218515 0,14927302 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,14218515 0,1492089 ! viral reproduction GO:0016032 142 68 0,000 0,14218515 0,14914483 ! adaptive immune response GO:0002250 126 68 0,000 0,14218515 0,14908082 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,14218515 0,14901687 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,14411956 0,15097945 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,14411956 0,15091474 ! urogenital system development GO:0001655 149 69 0,000 0,14411956 0,15085008 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,14411956 0,15078548 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,14411956 0,15072093 ! single fertilization GO:0007338 83 69 0,000 0,14411956 0,15065643 ! cell redox homeostasis GO:0045454 114 70 0,000 0,14604966 0,15260878 ! activation of immune response GO:0002253 120 70 0,000 0,14604966 0,15254354 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,14604966 0,15247835 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,14797547 0,15442293 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,14797547 0,15435699 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,14797547 0,15429111 ! appendage morphogenesis GO:0035107 150 72 0,000 0,14989699 0,15622796 GO:0035108|limb morphogenesis, ! actin filament organization GO:0007015 167 72 0,000 0,14989699 0,15616134 ! B cell activation GO:0042113 179 72 0,000 0,14989699 0,15609477 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,14989699 0,15602827 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,14989699 0,15596181 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,14989699 0,15589542 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,14989699 0,15582908 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,14989699 0,1557628 ! appendage development GO:0048736 151 73 0,000 0,15181422 0,15768799 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,15181422 0,15762097 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,15181422 0,15755401 ! regulation of immune effector process GO:0002697 156 73 0,000 0,15181422 0,15748711 ! acute inflammatory response GO:0002526 118 74 0,000 0,15372719 0,15940387 ! amino acid transport GO:0006865 148 74 0,000 0,15372719 0,15933624 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,15372719 0,15926867 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,1556359 0,16117783 ! eye development GO:0001654 155 75 0,000 0,1556359 0,16110953 ! rhythmic process GO:0048511 142 75 0,000 0,1556359 0,1610413 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,15754035 0,16294288 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,15754035 0,16287392 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,15754035 0,16280503 ! regulation of blood pressure GO:0008217 134 76 0,000 0,15754035 0,16273619 ! amine catabolic process GO:0009310 136 77 0,000 0,15944057 0,16462946 ! neurotransmitter transport GO:0006836 142 77 0,000 0,15944057 0,16455991 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,15944057 0,16449042 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,15944057 0,16442098 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,15944057 0,16435161 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,16133655 0,16623584 ! antigen processing and presentation GO:0019882 117 78 0,000 0,16133655 0,16616576 ! fertilization GO:0009566 99 78 0,000 0,16133655 0,16609574 ! blood coagulation GO:0007596 151 79 0,000 0,16322831 0,16797251 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,16322831 0,16790179 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,16322831 0,16783112 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,16322831 0,16776052 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,16322831 0,16768997 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,16511585 0,16955781 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,16511585 0,16948656 ! muscle cell differentiation GO:0042692 178 81 0,000 0,16699919 0,17134776 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,16699919 0,17127583 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,16887833 0,17313041 ! protein import into nucleus GO:0006606 174 82 0,000 0,16887833 0,17305779 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,17075329 0,17490578 ! exocytosis GO:0006887 153 83 0,000 0,17075329 0,17483247 ! response to drug GO:0042493 149 83 0,000 0,17075329 0,17475923 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,17075329 0,17468605 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,17075329 0,17461293 ! nuclear import GO:0051170 177 83 0,000 0,17075329 0,17453987 ! inorganic anion transport GO:0015698 156 83 0,000 0,17075329 0,17446687 ! response to metal ion GO:0010038 158 84 0,000 0,17262407 0,1763046 ! digestion GO:0007586 130 84 0,000 0,17262407 0,17623092 ! regulation of ligase activity GO:0051340 147 84 0,000 0,17262407 0,17615731 ! hemostasis GO:0007599 165 85 0,000 0,17449068 0,17798778 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,17449068 0,1779135 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,17449068 0,17783927 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,17449068 0,17776511 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,17449068 0,17769101 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,17635314 0,1795128 ! regulation of lyase activity GO:0051339 169 86 0,000 0,17635314 0,17943803 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,17821144 0,18125335 ! mitochondrion organization GO:0007005 159 87 0,000 0,17821144 0,18117792 ! nucleosome assembly GO:0006334 126 87 0,000 0,17821144 0,18110256 ! cellular respiration GO:0045333 143 88 0,000 0,1800656 0,18291071 ! amine biosynthetic process GO:0009309 146 88 0,000 0,1800656 0,18283469 ! sensory perception of smell GO:0007608 117 88 0,000 0,1800656 0,18275873 ! chromatin assembly GO:0031497 128 88 0,000 0,1800656 0,18268284 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,1800656 0,182607 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,18191564 0,1844066 ! tube morphogenesis GO:0035239 194 89 0,000 0,18191564 0,18433011 ! cellular defense response GO:0006968 123 89 0,000 0,18191564 0,18425369 ! protein localization in nucleus GO:0034504 192 89 0,000 0,18191564 0,18417733 ! regulation of neurological system process GO:0031644 175 89 0,000 0,18191564 0,18410103 ! response to inorganic substance GO:0010035 173 90 0,000 0,18376155 0,18589211 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,18376155 0,18581517 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,18376155 0,18573829 ! response to unfolded protein GO:0006986 139 90 0,000 0,18376155 0,18566148 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,18560334 0,1874448 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,18560334 0,18736734 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,18744104 0,18914434 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,18927463 0,19091574 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,18927463 0,19083695 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,18927463 0,19075822 ! vitamin metabolic process GO:0006766 153 93 0,000 0,18927463 0,19067956 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,19110415 0,19244329 ! female pregnancy GO:0007565 166 94 0,000 0,19110415 0,192364 ! sterol metabolic process GO:0016125 166 94 0,000 0,19110415 0,19228477 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,19110415 0,19220561 ! regulation of defense response GO:0031347 171 95 0,000 0,19292958 0,19396171 ! nucleosome organization GO:0034728 143 95 0,000 0,19292958 0,19388193 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,19292958 0,19380221 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,19292958 0,19372255 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,19292958 0,19364296 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,19292958 0,19356344 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,19292958 0,19348398 ! response to protein stimulus GO:0051789 158 96 0,000 0,19475095 0,19523043 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,19656826 0,19697139 ! transcription initiation GO:0006352 171 97 0,000 0,19656826 0,19689063 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,19838151 0,19862542 ! mRNA transport GO:0051028 185 100 0,000 0,20199591 0,20216142 ! positive regulation of immune response GO:0050778 175 100 0,000 0,20199591 0,20207863 ! hormone metabolic process GO:0042445 171 100 0,000 0,20199591 0,20199591