pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6460-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 8,929E-07 2,054E-03 ! response to gamma radiation GO:0010332 20 12 3,000 2,134E-06 2,455E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 5,522E-06 4,233E-03 ! peptidyl-amino acid modification GO:0018193 147 93 6,000 1,22E-05 7,015E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,909E-05 8,782E-03 ! B cell lineage commitment GO:0002326 17 7 2,000 1,909E-05 7,318E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 1,909E-05 6,273E-03 ! positive regulation of inflammatory response GO:0050729 30 20 3,000 1,984E-05 5,704E-03 ! cell aging GO:0007569 32 21 3,000 2,435E-05 6,223E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 3,036E-05 6,983E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 3,036E-05 6,348E-03 ! regulation of embryonic development GO:0045995 16 8 2,000 3,036E-05 5,819E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 3,000 3,556E-05 6,292E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 3,556E-05 5,843E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 4,24E-05 6,502E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 4,526E-05 6,506E-03 ! oocyte differentiation GO:0009994 12 9 2,000 4,526E-05 6,124E-03 GO:0048599|oocyte development, ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 5,015E-05 6,409E-03 ! response to X-ray GO:0010165 16 10 2,000 6,427E-05 7,78E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 6,427E-05 7,391E-03 ! protein sumoylation GO:0016925 12 10 2,000 6,427E-05 7,039E-03 ! response to ionizing radiation GO:0010212 47 27 3,000 6,869E-05 7,181E-03 ! cell junction assembly GO:0034329 56 28 3,000 7,963E-05 7,963E-03 ! cell cycle arrest GO:0007050 150 86 5,000 7,999E-05 7,665E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 8,783E-05 8,08E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 24 11 2,000 8,783E-05 7,77E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 8,783E-05 7,482E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 8,783E-05 7,215E-03 GO:0010829|negative regulation of glucose transport, ! response to peptide hormone stimulus GO:0043434 84 57 4,000 1,084E-04 8,599E-03 ! activation of MAPK activity GO:0000187 84 59 4,000 1,279E-04 9,807E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,504E-04 0,01115838 ! intermediate filament cytoskeleton organization GO:0045104 23 13 2,000 1,504E-04 0,01080968 ! cellular pigmentation GO:0033059 24 13 2,000 1,504E-04 0,01048211 ! cell junction organization GO:0034330 63 33 3,000 1,541E-04 0,01042408 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 1,735E-04 0,01140284 ! intermediate filament-based process GO:0045103 24 14 2,000 1,903E-04 0,01215489 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,903E-04 0,01182638 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 2,364E-04 0,0143066 ! pigmentation GO:0043473 74 38 3,000 2,692E-04 0,01587456 ! regulation of catabolic process GO:0009894 106 70 4,000 2,875E-04 0,01652959 ! fructose metabolic process GO:0006000 20 16 2,000 2,892E-04 0,01622072 ! oogenesis GO:0048477 23 16 2,000 2,892E-04 0,01583451 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,892E-04 0,01546627 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 3,29E-04 0,01719842 ! inactivation of MAPK activity GO:0000188 27 17 2,000 3,49E-04 0,01783696 ! cell-substrate junction assembly GO:0007044 39 17 2,000 3,49E-04 0,0174492 ! negative regulation of protein catabolic process GO:0042177 26 17 2,000 3,49E-04 0,01707794 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 3,726E-04 0,01785391 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 4,162E-04 0,0195379 ! regulation of glucose import GO:0046324 21 18 2,000 4,162E-04 0,01914715 GO:0010827|regulation of glucose transport, ! response to insulin stimulus GO:0032868 63 43 3,000 4,358E-04 0,01965438 ! glycolysis GO:0006096 53 44 3,000 4,763E-04 0,02106844 ! regulation of inflammatory response GO:0050727 60 44 3,000 4,763E-04 0,02067092 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 4,913E-04 0,02092543 ! positive regulation of defense response GO:0031349 59 45 3,000 5,195E-04 0,0217228 ! response to UV GO:0009411 75 46 3,000 5,653E-04 0,02321742 ! regulation of cell cycle process GO:0010564 122 81 4,000 5,658E-04 0,02283013 ! response to ethanol GO:0045471 37 20 2,000 5,745E-04 0,02278151 ! positive regulation of locomotion GO:0040017 35 20 2,000 5,745E-04 0,02239539 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of muscle contraction GO:0006937 69 48 3,000 6,655E-04 0,02550941 ! regulation of DNA replication GO:0006275 75 48 3,000 6,655E-04 0,02509123 ! regulation of chemotaxis GO:0050920 36 21 2,000 6,662E-04 0,02471315 ! microtubule cytoskeleton organization GO:0000226 120 84 4,000 6,683E-04 0,02439942 ! sleep GO:0030431 11 5 1,000 6,721E-04 0,02415463 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 6,721E-04 0,02378302 ! neurofilament cytoskeleton organization GO:0060052 8 5 1,000 6,721E-04 0,02342267 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 1,000 6,721E-04 0,02307308 ! positive regulation of glycolysis GO:0045821 11 5 1,000 6,721E-04 0,02273377 ! microvillus organization GO:0032528 7 5 1,000 6,721E-04 0,02240429 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 1,000 6,721E-04 0,02208423 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 6,721E-04 0,02177319 ! peptidyl-histidine phosphorylation GO:0018106 7 5 1,000 6,721E-04 0,02147078 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 6,721E-04 0,02117666 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 6,721E-04 0,02089049 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 6,721E-04 0,02061195 GO:0045686|negative regulation of glial cell differentiation, ! centrosome duplication GO:0051298 5 5 1,000 6,721E-04 0,02034074 ! response to UV-C GO:0010225 6 5 1,000 6,721E-04 0,02007658 ! regulation of respiratory burst GO:0060263 8 5 1,000 6,721E-04 0,01981918 ! apical protein localization GO:0045176 6 5 1,000 6,721E-04 0,01956831 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 6,721E-04 0,0193237 ! regulation of sensory perception GO:0051931 6 5 1,000 6,721E-04 0,01908514 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 6,721E-04 0,01885239 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 7,054E-04 0,0195478 ! integrin-mediated signaling pathway GO:0007229 81 49 3,000 7,2E-04 0,01971392 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 7,667E-04 0,02074595 ! regulation of behavior GO:0050795 38 22 2,000 7,667E-04 0,02050472 ! protein tetramerization GO:0051262 39 22 2,000 7,667E-04 0,02026903 ! positive regulation of growth GO:0045927 67 50 3,000 7,776E-04 0,02032354 ! regulation of protein catabolic process GO:0042176 77 51 3,000 8,384E-04 0,02166619 ! reproductive developmental process GO:0003006 127 89 4,000 8,694E-04 0,02221674 ! negative regulation of DNA replication GO:0008156 35 23 2,000 8,764E-04 0,02214997 ! lymphocyte proliferation GO:0046651 36 23 2,000 8,764E-04 0,02190921 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 8,764E-04 0,02167362 ! negative regulation of catabolic process GO:0009895 34 23 2,000 8,764E-04 0,02144305 ! aging GO:0007568 79 52 3,000 9,025E-04 0,02184893 ! mitochondrial membrane organization GO:0007006 39 24 2,000 9,955E-04 0,02385067 ! negative regulation of cell development GO:0010721 56 24 2,000 9,955E-04 0,02360479 GO:0050768|negative regulation of neurogenesis, ! regulation of helicase activity GO:0051095 11 6 1,000 1,003E-03 0,02353288 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 1,003E-03 0,02329517 ! prostate gland development GO:0030850 9 6 1,000 1,003E-03 0,02306222 ! male meiosis GO:0007140 7 6 1,000 1,003E-03 0,02283388 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,003E-03 0,02261002 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,003E-03 0,02239051 ! amyloid precursor protein catabolic process GO:0042987 9 6 1,000 1,003E-03 0,02217521 ! pigment granule organization GO:0048753 11 6 1,000 1,003E-03 0,02196402 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,003E-03 0,02175681 ! hyperosmotic response GO:0006972 8 6 1,000 1,003E-03 0,02155348 ! ER overload response GO:0006983 7 6 1,000 1,003E-03 0,02135391 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,003E-03 0,021158 ! male sex determination GO:0030238 9 6 1,000 1,003E-03 0,02096566 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 1,003E-03 0,02077678 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,003E-03 0,02059127 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,003E-03 0,02040905 ! peptidyl-histidine modification GO:0018202 9 6 1,000 1,003E-03 0,02023002 ! midbrain development GO:0030901 6 6 1,000 1,003E-03 0,02005411 ! blastocyst growth GO:0001832 15 6 1,000 1,003E-03 0,01988123 ! glucose catabolic process GO:0006007 66 54 3,000 1,041E-03 0,02046027 ! leukocyte proliferation GO:0070661 39 25 2,000 1,124E-03 0,02191662 GO:0032943|mononuclear cell proliferation, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 1,124E-03 0,02173244 GO:0045936|negative regulation of phosphate metabolic process, ! DNA damage response, signal transduction GO:0042770 96 56 3,000 1,193E-03 0,02287368 ! response to light stimulus GO:0009416 153 96 4,000 1,222E-03 0,02323476 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,263E-03 0,02381818 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 1,263E-03 0,02362454 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 1,275E-03 0,02365468 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 4,000 1,28E-03 0,02355756 ! negative regulation of kinase activity GO:0033673 100 58 3,000 1,361E-03 0,02484423 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,396E-03 0,02528463 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,396E-03 0,02508709 ! microtubule bundle formation GO:0001578 8 7 1,000 1,396E-03 0,02489262 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,396E-03 0,02470113 ! asymmetric protein localization GO:0008105 8 7 1,000 1,396E-03 0,02451258 ! organ growth GO:0035265 11 7 1,000 1,396E-03 0,02432688 ! behavioral fear response GO:0001662 13 7 1,000 1,396E-03 0,02414397 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,396E-03 0,02396379 ! protein heterooligomerization GO:0051291 10 7 1,000 1,396E-03 0,02378628 ! response to UV-B GO:0010224 11 7 1,000 1,396E-03 0,02361138 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,396E-03 0,02343903 ! intermediate filament organization GO:0045109 11 7 1,000 1,396E-03 0,02326919 ! response to tumor cell GO:0002347 12 7 1,000 1,396E-03 0,02310178 ! neuroblast proliferation GO:0007405 13 7 1,000 1,396E-03 0,02293677 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,396E-03 0,0227741 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,396E-03 0,02261372 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 1,402E-03 0,02255393 ! regulation of heart contraction GO:0008016 91 60 3,000 1,544E-03 0,02466803 ! response to organic cyclic substance GO:0014070 47 28 2,000 1,573E-03 0,02494645 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 1,573E-03 0,02477559 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,573E-03 0,02460704 ! positive regulation of catabolic process GO:0009896 40 28 2,000 1,573E-03 0,02444078 ! cell-matrix adhesion GO:0007160 114 61 3,000 1,642E-03 0,02535076 ! negative regulation of transferase activity GO:0051348 105 61 3,000 1,642E-03 0,02518175 ! tissue homeostasis GO:0001894 42 29 2,000 1,744E-03 0,02655797 GO:0048871|multicellular organismal homeostasis, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 1,851E-03 0,02800518 ! succinate metabolic process GO:0006105 14 8 1,000 1,851E-03 0,02783173 ! amyloid precursor protein metabolic process GO:0042982 12 8 1,000 1,851E-03 0,027651 ! melanin metabolic process GO:0006582 12 8 1,000 1,851E-03 0,02747261 ! multicellular organism growth GO:0035264 14 8 1,000 1,851E-03 0,0272965 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,851E-03 0,02712264 GO:0045685|regulation of glial cell differentiation, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,851E-03 0,02695098 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,851E-03 0,02678147 ! S phase GO:0051320 8 8 1,000 1,851E-03 0,02661409 GO:0000084|S phase of mitotic cell cycle, ! hindbrain development GO:0030902 45 30 2,000 1,926E-03 0,02750901 ! regulation of microtubule-based process GO:0032886 58 30 2,000 1,926E-03 0,0273392 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 1,962E-03 0,027679 ! hexose catabolic process GO:0019320 82 64 3,000 1,962E-03 0,02751023 ! reproductive structure development GO:0048608 90 65 3,000 2,077E-03 0,02895114 ! protein oligomerization GO:0051259 100 65 3,000 2,077E-03 0,02877673 ! leukocyte chemotaxis GO:0030595 43 31 2,000 2,119E-03 0,02918505 GO:0060326|cell chemotaxis, ! cell-substrate adhesion GO:0031589 121 66 3,000 2,197E-03 0,03007609 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 2,324E-03 0,03163119 ! regulation of developmental growth GO:0048638 13 9 1,000 2,367E-03 0,03203032 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,367E-03 0,03184301 ! regulation of glycolysis GO:0006110 15 9 1,000 2,367E-03 0,03165788 ! T cell selection GO:0045058 18 9 1,000 2,367E-03 0,03147488 ! phosphagen metabolic process GO:0006599 12 9 1,000 2,367E-03 0,03129399 GO:0006600|creatine metabolic process, ! indolalkylamine metabolic process GO:0006586 14 9 1,000 2,367E-03 0,03111517 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 2,367E-03 0,03093838 ! response to amine stimulus GO:0014075 13 9 1,000 2,367E-03 0,03076359 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 2,367E-03 0,03059076 ! thymus development GO:0048538 15 9 1,000 2,367E-03 0,03041986 ! spleen development GO:0048536 15 9 1,000 2,367E-03 0,03025086 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 2,367E-03 0,03008373 ! sequestering of metal ion GO:0051238 11 9 1,000 2,367E-03 0,02991843 ! response to nicotine GO:0035094 16 9 1,000 2,367E-03 0,02975494 ! female gonad development GO:0008585 49 33 2,000 2,541E-03 0,0317652 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 2,541E-03 0,0315935 ! response to drug GO:0042493 108 69 3,000 2,585E-03 0,03196738 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 2,724E-03 0,0335092 ! female gamete generation GO:0007292 43 34 2,000 2,77E-03 0,03389255 ! monosaccharide catabolic process GO:0046365 91 71 3,000 2,869E-03 0,03491079 ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,943E-03 0,03562889 ! hippocampus development GO:0021766 19 10 1,000 2,943E-03 0,03544236 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,943E-03 0,03525776 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 2,943E-03 0,03507508 ! B cell proliferation GO:0042100 14 10 1,000 2,943E-03 0,03489428 ! fear response GO:0042596 16 10 1,000 2,943E-03 0,03471533 ! negative regulation of ossification GO:0030279 19 10 1,000 2,943E-03 0,03453821 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,943E-03 0,03436289 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,943E-03 0,03418934 GO:0043470|regulation of carbohydrate catabolic process, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 2,943E-03 0,03401754 ! glycogen metabolic process GO:0005977 48 35 2,000 3,012E-03 0,03463592 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 3,018E-03 0,0345368 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 116 73 3,000 3,173E-03 0,03612719 ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 3,266E-03 0,03700213 GO:0090047|positive regulation of transcription regulator activity, ! development of primary female sexual characteristics GO:0046545 52 36 2,000 3,266E-03 0,03682075 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 2,000 3,266E-03 0,03664114 GO:0006073|cellular glucan metabolic process, ! learning GO:0007612 67 37 2,000 3,533E-03 0,03944182 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 3,578E-03 0,03975328 ! virus-host interaction GO:0019048 17 11 1,000 3,578E-03 0,03956216 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 3,578E-03 0,03937287 GO:0000725|recombinational repair, ! T cell proliferation GO:0042098 20 11 1,000 3,578E-03 0,03918538 ! negative regulation of proteolysis GO:0045861 16 11 1,000 3,578E-03 0,03899967 ! regulation of mRNA processing GO:0050684 18 11 1,000 3,578E-03 0,03881571 ! regulation of intracellular pH GO:0051453 17 11 1,000 3,578E-03 0,03863347 ! membrane protein proteolysis GO:0033619 18 11 1,000 3,578E-03 0,03845294 GO:0006509|membrane protein ectodomain proteolysis, ! T cell homeostasis GO:0043029 20 11 1,000 3,578E-03 0,03827409 ! digestive tract morphogenesis GO:0048546 15 11 1,000 3,578E-03 0,0380969 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! gland development GO:0048732 148 77 3,000 3,846E-03 0,04076181 ! sex differentiation GO:0007548 105 77 3,000 3,846E-03 0,04057483 ! positive regulation of protein modification process GO:0031401 107 78 3,000 4,028E-03 0,04230282 ! developmental growth GO:0048589 62 39 2,000 4,105E-03 0,04291798 ! cell growth GO:0016049 61 39 2,000 4,105E-03 0,04272378 ! T cell activation GO:0042110 134 79 3,000 4,216E-03 0,04367816 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 4,27E-03 0,04404114 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 4,27E-03 0,04384453 ! glycoprotein catabolic process GO:0006516 19 12 1,000 4,27E-03 0,04364966 ! cell-cell junction assembly GO:0007043 18 12 1,000 4,27E-03 0,04345652 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 4,27E-03 0,04326508 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! gastrulation with mouth forming second GO:0001702 15 12 1,000 4,27E-03 0,04307532 ! histone acetylation GO:0016573 23 12 1,000 4,27E-03 0,04288722 ! histone methylation GO:0016571 15 12 1,000 4,27E-03 0,04270076 ! gland morphogenesis GO:0022612 23 12 1,000 4,27E-03 0,0425159 ! peptidyl-lysine modification GO:0018205 18 12 1,000 4,27E-03 0,04233265 ! alcohol catabolic process GO:0046164 104 80 3,000 4,41E-03 0,04352878 ! T cell differentiation GO:0030217 65 40 2,000 4,411E-03 0,04335967 ! double-strand break repair GO:0006302 67 40 2,000 4,411E-03 0,04317516 ! B cell differentiation GO:0030183 62 40 2,000 4,411E-03 0,04299222 ! energy reserve metabolic process GO:0006112 59 41 2,000 4,731E-03 0,04591308 ! positive regulation of DNA binding GO:0043388 57 41 2,000 4,731E-03 0,04572016 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 5,019E-03 0,04830104 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 5,019E-03 0,04809979 ! regulation of cellular pH GO:0030641 20 13 1,000 5,019E-03 0,0479002 ! lymphocyte homeostasis GO:0002260 24 13 1,000 5,019E-03 0,04770227 ! mitochondrial transport GO:0006839 60 42 2,000 5,064E-03 0,04793435 ! regulation of defense response GO:0031347 117 84 3,000 5,245E-03 0,04943776 ! positive regulation of binding GO:0051099 59 43 2,000 5,412E-03 0,05080193 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 5,412E-03 0,05059541 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 5,412E-03 0,05039057 ! leukocyte migration GO:0050900 60 43 2,000 5,412E-03 0,05018739 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 5,412E-03 0,04998583 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 5,469E-03 0,05031354 ! regulation of membrane potential GO:0042391 128 85 3,000 5,469E-03 0,05011309 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 5,699E-03 0,05201782 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 5,773E-03 0,05247837 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 5,824E-03 0,05273627 ! regulation of S phase GO:0033261 18 14 1,000 5,824E-03 0,05252946 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,824E-03 0,05232426 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 5,824E-03 0,05212067 ! cardiac muscle contraction GO:0060048 23 14 1,000 5,824E-03 0,05191865 ! limbic system development GO:0021761 25 14 1,000 5,824E-03 0,05171819 ! startle response GO:0001964 21 14 1,000 5,824E-03 0,05151927 ! epidermis morphogenesis GO:0048730 29 14 1,000 5,824E-03 0,05132188 ! cellular response to starvation GO:0009267 21 14 1,000 5,824E-03 0,051126 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 5,824E-03 0,0509316 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 5,824E-03 0,05073868 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 5,824E-03 0,05054721 ! G1/S transition checkpoint GO:0031575 33 14 1,000 5,824E-03 0,05035719 ! axon cargo transport GO:0008088 27 14 1,000 5,824E-03 0,05016858 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 5,824E-03 0,04998139 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 5,824E-03 0,04979558 ! muscle maintenance GO:0046716 19 14 1,000 5,824E-03 0,04961115 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 6,148E-03 0,05217729 ! anatomical structure homeostasis GO:0060249 136 88 3,000 6,18E-03 0,05225367 ! interphase GO:0051325 159 88 3,000 6,18E-03 0,05206226 ! regulation of neurogenesis GO:0050767 153 89 3,000 6,429E-03 0,05396989 ! histone modification GO:0016570 68 46 2,000 6,537E-03 0,05467582 ! metencephalon development GO:0022037 19 15 1,000 6,684E-03 0,05569617 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 6,684E-03 0,0554951 ! lipid phosphorylation GO:0046834 23 15 1,000 6,684E-03 0,05529548 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 6,684E-03 0,05509729 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 1,000 6,684E-03 0,05490051 ! centrosome cycle GO:0007098 16 15 1,000 6,684E-03 0,05470514 ! response to osmotic stress GO:0006970 22 15 1,000 6,684E-03 0,05451115 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 6,684E-03 0,05431853 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 6,684E-03 0,05412727 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 6,684E-03 0,05393735 ! dopamine metabolic process GO:0042417 30 15 1,000 6,684E-03 0,05374875 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 6,684E-03 0,05356148 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 6,684E-03 0,0533755 ! defense response to virus GO:0051607 27 15 1,000 6,684E-03 0,05319081 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 6,684E-03 0,05300739 ! protein modification by small protein conjugation GO:0032446 140 90 3,000 6,686E-03 0,05284443 ! response to estrogen stimulus GO:0043627 74 47 2,000 6,941E-03 0,05467379 ! covalent chromatin modification GO:0016569 75 47 2,000 6,941E-03 0,05448719 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 6,941E-03 0,05430186 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 7,36E-03 0,05737975 ! carbohydrate catabolic process GO:0016052 121 93 3,000 7,496E-03 0,05824564 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 7,597E-03 0,05883218 ! protein amino acid acetylation GO:0006473 28 16 1,000 7,597E-03 0,05863476 ! regulation of protein binding GO:0043393 27 16 1,000 7,597E-03 0,05843865 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 7,597E-03 0,05824386 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 7,597E-03 0,05805036 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 7,597E-03 0,05785814 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 7,597E-03 0,05766719 ! germ cell development GO:0007281 68 49 2,000 7,793E-03 0,05895712 ! cartilage development GO:0051216 70 49 2,000 7,793E-03 0,05876382 ! regulation of binding GO:0051098 151 95 3,000 8,07E-03 0,06065967 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 8,24E-03 0,06173559 ! regulation of response to external stimulus GO:0032101 139 96 3,000 8,368E-03 0,06248917 ! protein modification by small protein conjugation or removal GO:0070647 148 96 3,000 8,368E-03 0,06228694 ! memory GO:0007613 25 17 1,000 8,563E-03 0,06353513 ! regulation of viral genome replication GO:0045069 24 17 1,000 8,563E-03 0,06333084 ! regulation of striated muscle contraction GO:0006942 20 17 1,000 8,563E-03 0,06312785 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 8,563E-03 0,06292617 ! actin filament bundle formation GO:0051017 26 17 1,000 8,563E-03 0,06272576 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 8,563E-03 0,06252663 ! peptidyl-serine modification GO:0018209 27 17 1,000 8,563E-03 0,06232877 ! cell-cell junction organization GO:0045216 25 17 1,000 8,563E-03 0,06213214 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 8,563E-03 0,06193676 ! positive regulation of cell migration GO:0030335 92 51 2,000 8,703E-03 0,06274878 ! nucleotide-excision repair GO:0006289 64 52 2,000 9,181E-03 0,06598532 ! positive regulation of DNA replication GO:0045740 29 18 1,000 9,582E-03 0,06865485 ! heart process GO:0003015 27 18 1,000 9,582E-03 0,06844163 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 1,000 9,582E-03 0,06822974 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 1,000 9,582E-03 0,06801916 ! somitogenesis GO:0001756 24 18 1,000 9,582E-03 0,06780987 ! cellular response to nutrient levels GO:0031669 27 18 1,000 9,582E-03 0,06760186 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 9,582E-03 0,06739513 ! activation of JUN kinase activity GO:0007257 23 18 1,000 9,582E-03 0,06718965 ! gut development GO:0048565 26 18 1,000 9,582E-03 0,06698543 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 9,582E-03 0,06678244 ! skeletal system morphogenesis GO:0048705 78 53 2,000 9,673E-03 0,06721563 ! regulation of mitosis GO:0007088 84 54 2,000 0,01018099 0,07053098 GO:0051783|regulation of nuclear division, ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,0106513 0,07356756 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,0106513 0,0733473 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 1,000 0,0106513 0,07312835 ! regeneration GO:0031099 32 19 1,000 0,0106513 0,07291071 ! response to alkaloid GO:0043279 32 19 1,000 0,0106513 0,07269436 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 0,0106513 0,07247929 ! vesicle docking during exocytosis GO:0006904 24 19 1,000 0,0106513 0,07226548 ! response to starvation GO:0042594 30 19 1,000 0,0106513 0,07205294 ! sex determination GO:0007530 29 19 1,000 0,0106513 0,07184164 ! renal system process GO:0003014 35 19 1,000 0,0106513 0,07163157 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 0,0106513 0,07142274 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 0,01124235 0,07516689 ! positive regulation of cell motion GO:0051272 99 56 2,000 0,01124235 0,07494902 ! microtubule-based transport GO:0010970 37 20 1,000 0,01177095 0,0782462 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01177095 0,0780207 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01177095 0,07779651 ! pallium development GO:0021543 38 20 1,000 0,01177095 0,07757359 ! gonad development GO:0008406 79 57 2,000 0,01179608 0,07751708 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 0,01236526 0,08102593 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01293987 0,0845503 ! gluconeogenesis GO:0006094 25 21 1,000 0,01293987 0,08431079 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01293987 0,08407262 ! vesicle docking GO:0048278 27 21 1,000 0,01293987 0,0838358 ! dendrite development GO:0016358 35 21 1,000 0,01293987 0,0836003 ! visual behavior GO:0007632 39 21 1,000 0,01293987 0,08336613 ! ovarian follicle development GO:0001541 30 21 1,000 0,01293987 0,08313326 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 0,01293987 0,08290169 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01293987 0,08267141 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01293987 0,0824424 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01293987 0,08221466 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01293987 0,08198817 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01293987 0,08176293 ! actin filament organization GO:0007015 95 59 2,000 0,01294997 0,08160255 ! regulation of homeostatic process GO:0032844 105 60 2,000 0,01355026 0,08515192 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01415719 0,08872354 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01415719 0,08848244 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01415719 0,08824265 ! spliceosomal snRNP biogenesis GO:0000387 28 22 1,000 0,01415719 0,08800416 ! molting cycle process GO:0022404 40 22 1,000 0,01415719 0,08776695 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01415719 0,08753101 ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01415719 0,08729635 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01415719 0,08706293 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01415719 0,08683077 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 0,01415719 0,08659983 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! ureteric bud development GO:0001657 32 22 1,000 0,01415719 0,08637013 ! membrane depolarization GO:0051899 35 22 1,000 0,01415719 0,08614163 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01415719 0,08591435 ! blastocyst development GO:0001824 37 22 1,000 0,01415719 0,08568826 ! neural tube closure GO:0001843 33 22 1,000 0,01415719 0,08546335 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 0,01415719 0,08523963 ! urogenital system development GO:0001655 101 61 2,000 0,01416619 0,08507112 ! negative regulation of cell growth GO:0030308 106 62 2,000 0,01479781 0,08863271 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01542203 0,09213161 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01542203 0,09189293 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01542203 0,09165548 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01542203 0,09141925 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01542203 0,09118424 ! interaction with host GO:0051701 37 23 1,000 0,01542203 0,09095044 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,01544516 0,09085389 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,01544516 0,09062212 ! negative regulation of cell size GO:0045792 108 64 2,000 0,01610829 0,09427242 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,01673353 0,09768306 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,01673353 0,09743576 ! response to toxin GO:0009636 38 24 1,000 0,01673353 0,09718971 ! primary neural tube formation GO:0014020 35 24 1,000 0,01673353 0,0969449 ! base-excision repair GO:0006284 31 24 1,000 0,01673353 0,09670132 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01673353 0,09645896 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,01673353 0,09621781 ! B cell activation GO:0042113 104 65 2,000 0,01678722 0,09628582 ! protein amino acid alkylation GO:0008213 39 25 1,000 0,01809085 0,10350485 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,01809085 0,10324801 ! male gonad development GO:0008584 33 25 1,000 0,01809085 0,10299245 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01809085 0,10273814 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01809085 0,10248509 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,01819265 0,1028086 ! learning or memory GO:0007611 123 68 2,000 0,01891919 0,10665232 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01891919 0,10639155 ! regulation of pH GO:0006885 36 26 1,000 0,01949313 0,10935173 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01949313 0,10908567 ! post-embryonic development GO:0009791 42 26 1,000 0,01949313 0,10882089 ! membrane docking GO:0022406 39 27 1,000 0,02093957 0,11661259 ! catechol metabolic process GO:0009712 43 27 1,000 0,02093957 0,11633092 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02093957 0,11605061 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,02093957 0,11577164 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,02119435 0,1168993 ! response to hypoxia GO:0001666 132 72 2,000 0,02198462 0,120968 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,02198462 0,12067929 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,02242932 0,12282725 ! phenol metabolic process GO:0018958 44 28 1,000 0,02242932 0,1225355 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,02242932 0,12224513 GO:0002764|immune response-regulating signal transduction, ! BMP signaling pathway GO:0030509 40 28 1,000 0,02242932 0,12195614 ! neural tube formation GO:0001841 41 28 1,000 0,02242932 0,1216685 ! tube morphogenesis GO:0035239 118 73 2,000 0,02279083 0,12333864 ! mitochondrion organization GO:0007005 104 73 2,000 0,02279083 0,12304911 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,02279083 0,12276094 ! response to oxygen levels GO:0070482 137 74 2,000 0,023613 0,12689229 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,0239616 0,12846546 ! ovulation cycle process GO:0022602 41 29 1,000 0,0239616 0,1281667 ! mismatch repair GO:0006298 34 29 1,000 0,0239616 0,12786933 ! telencephalon development GO:0021537 52 29 1,000 0,0239616 0,12757334 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,0239616 0,12727871 ! negative regulation of growth GO:0045926 123 75 2,000 0,02445111 0,12957962 ! response to nutrient GO:0007584 104 75 2,000 0,02445111 0,12928173 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,0255356 0,13470614 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,0255356 0,13439789 ! ovulation cycle GO:0042698 43 30 1,000 0,0255356 0,13409104 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,0255356 0,1337856 ! response to heat GO:0009408 41 30 1,000 0,0255356 0,13348154 ! regulation of DNA binding GO:0051101 119 77 2,000 0,02617513 0,1365143 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02715053 0,14128104 ! mammary gland development GO:0030879 57 31 1,000 0,02715053 0,14096212 ! segmentation GO:0035282 41 31 1,000 0,02715053 0,14064464 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02715053 0,14032858 ! metanephros development GO:0001656 58 31 1,000 0,02715053 0,14001395 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02715053 0,13970072 ! regulation of muscle development GO:0048634 48 32 1,000 0,02880562 0,14788599 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,02880562 0,14755662 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,02880562 0,14722872 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02880562 0,14690227 ! regulation of protein stability GO:0031647 48 32 1,000 0,02880562 0,14657726 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,02880562 0,14625369 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02880562 0,14593155 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,0305001 0,15417631 ! positive regulation of cell development GO:0010720 54 33 1,000 0,0305001 0,1538382 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,0305001 0,15350158 GO:0042593|glucose homeostasis, ! regulation of proteolysis GO:0030162 50 33 1,000 0,0305001 0,15316642 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,0305001 0,15283273 ! cytokinesis GO:0000910 52 33 1,000 0,0305001 0,15250048 ! regulation of cell adhesion GO:0030155 159 83 2,000 0,03172841 0,1582979 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,03223321 0,16046834 ! feeding behavior GO:0007631 45 34 1,000 0,03223321 0,16012176 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,03223321 0,15977667 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,03223321 0,15943306 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,03223321 0,15909093 ! rRNA metabolic process GO:0016072 107 85 2,000 0,03370588 0,16600329 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,03370588 0,16564858 ! regulation of protein localization GO:0032880 132 85 2,000 0,03370588 0,16529538 ! Notch signaling pathway GO:0007219 56 35 1,000 0,0340042 0,16640353 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,0340042 0,16605023 ! pigment metabolic process GO:0042440 61 35 1,000 0,0340042 0,16569843 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,0357461 0,17381823 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,03581234 0,17377295 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,03581234 0,17340711 ! neural tube development GO:0021915 50 36 1,000 0,03581234 0,17304281 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,03765689 0,18157412 ! leukocyte differentiation GO:0002521 143 90 2,000 0,03892327 0,18728772 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,03953715 0,18984433 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,03953715 0,18944882 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03953715 0,18905496 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,03953715 0,18866273 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04079355 0,19425502 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04079355 0,19385367 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04079355 0,19345397 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04079355 0,19305592 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04079355 0,1926595 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04079355 0,1922647 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04079355 0,19187152 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04079355 0,19147995 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04079355 0,19108997 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04079355 0,19070158 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04079355 0,19031476 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04079355 0,18992951 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04079355 0,18954581 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04079355 0,18916366 ! tongue development GO:0043586 6 5 0,000 0,04079355 0,18878305 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04079355 0,18840397 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04079355 0,1880264 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04079355 0,18765035 ! cobalt ion transport GO:0006824 9 5 0,000 0,04079355 0,1872758 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04079355 0,18690274 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04079355 0,18653116 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04079355 0,18616106 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04079355 0,18579243 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04079355 0,18542525 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04079355 0,18505952 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04079355 0,18469523 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04079355 0,18433237 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04079355 0,18397093 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04079355 0,18361091 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04079355 0,1832523 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04079355 0,18289508 ! malate metabolic process GO:0006108 7 5 0,000 0,04079355 0,18253925 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04079355 0,18218481 ! behavioral response to pain GO:0048266 7 5 0,000 0,04079355 0,18183174 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04079355 0,18148003 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04079355 0,18112968 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04079355 0,18078069 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04079355 0,18043303 ! mating behavior GO:0007617 6 5 0,000 0,04079355 0,18008671 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04079355 0,17974172 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04079355 0,17939804 ! rhythmic behavior GO:0007622 12 5 0,000 0,04079355 0,17905568 ! copulation GO:0007620 7 5 0,000 0,04079355 0,17871462 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04079355 0,17837486 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04079355 0,17803639 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04079355 0,1776992 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04079355 0,17736328 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04079355 0,17702863 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04079355 0,17669525 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04079355 0,17636311 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04079355 0,17603222 ! response to protozoan GO:0001562 9 5 0,000 0,04079355 0,17570258 ! lymph vessel development GO:0001945 7 5 0,000 0,04079355 0,17537416 ! endochondral ossification GO:0001958 12 5 0,000 0,04079355 0,17504697 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04079355 0,174721 ! parathyroid gland development GO:0060017 8 5 0,000 0,04079355 0,17439624 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04079355 0,17407268 ! anagen GO:0042640 6 5 0,000 0,04079355 0,17375033 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04079355 0,17342916 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04079355 0,17310918 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04079355 0,17279038 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04079355 0,17247275 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04079355 0,17215629 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04079355 0,17184098 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04079355 0,17152683 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04079355 0,17121382 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04079355 0,17090196 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,04079355 0,17059123 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04079355 0,17028163 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04079355 0,16997314 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,04079355 0,16966578 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04079355 0,16935952 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04079355 0,16905437 ! ovulation GO:0030728 6 5 0,000 0,04079355 0,16875032 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04079355 0,16844735 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 9 5 0,000 0,04079355 0,16814548 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04079355 0,16784468 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04079355 0,16754496 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04079355 0,1672463 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04079355 0,16694871 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04079355 0,16665218 ! polyol catabolic process GO:0046174 7 5 0,000 0,04079355 0,16635669 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04079355 0,16606226 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04079355 0,16576886 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04079355 0,1654765 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04079355 0,16518517 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04079355 0,16489486 ! urea metabolic process GO:0019627 6 5 0,000 0,04079355 0,16460557 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04079355 0,1643173 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04079355 0,16403003 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04079355 0,16374376 ! neutrophil activation GO:0042119 5 5 0,000 0,04079355 0,16345849 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04079355 0,16317422 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04079355 0,16289093 ! response to food GO:0032094 5 5 0,000 0,04079355 0,16260862 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04079355 0,16232729 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04079355 0,16204694 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04079355 0,16176754 ! forebrain neuron development GO:0021884 7 5 0,000 0,04079355 0,16148911 ! melanosome organization GO:0032438 7 5 0,000 0,04079355 0,16121164 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04079355 0,16093512 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04079355 0,16065955 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04079355 0,16038492 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04079355 0,16011122 GO:0009251|glucan catabolic process, ! nucleoside transport GO:0015858 6 5 0,000 0,04079355 0,15983846 ! nucleoside salvage GO:0043174 7 5 0,000 0,04079355 0,15956663 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04079355 0,15929571 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04079355 0,15902572 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04079355 0,15875664 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04079355 0,15848847 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04079355 0,15822121 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04079355 0,15795484 ! depyrimidination GO:0045008 8 5 0,000 0,04079355 0,15768937 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04079355 0,15742479 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04079355 0,1571611 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04079355 0,15689829 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04079355 0,15663635 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04079355 0,15637529 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04079355 0,1561151 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04079355 0,15585577 ! monocyte differentiation GO:0030224 8 5 0,000 0,04079355 0,15559731 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04079355 0,15533969 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04079355 0,15508293 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04079355 0,15482702 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04079355 0,15457195 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04079355 0,15431772 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04079355 0,15406433 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04079355 0,15381176 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04079355 0,15356003 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04079355 0,15330911 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04079355 0,15305901 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04079355 0,15280973 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04079355 0,15256126 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04079355 0,1523136 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04079355 0,15206674 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04079355 0,15182067 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04079355 0,1515754 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04079355 0,15133093 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04079355 0,15108724 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04079355 0,15084433 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04079355 0,15060221 ! neural tube patterning GO:0021532 6 5 0,000 0,04079355 0,15036086 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04079355 0,15012028 ! histone demethylation GO:0016577 9 5 0,000 0,04079355 0,14988047 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04079355 0,14964143 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04079355 0,14940315 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04079355 0,14916562 ! enteric nervous system development GO:0048484 8 5 0,000 0,04079355 0,14892885 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04079355 0,14869283 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04079355 0,14845756 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04079355 0,14822303 ! transcription termination GO:0006353 8 5 0,000 0,04079355 0,14798924 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04079355 0,14775618 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04079355 0,14752386 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04079355 0,14729227 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04079355 0,1470614 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04079355 0,14683126 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04079355 0,14660184 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04079355 0,14637313 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04079355 0,14614513 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04079355 0,14591785 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04079355 0,14569127 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04079355 0,14546539 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04079355 0,14524021 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04079355 0,14501573 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04079355 0,14479194 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04079355 0,14456884 ! glial cell migration GO:0008347 10 5 0,000 0,04079355 0,14434642 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04079355 0,14412469 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04079355 0,14390364 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04079355 0,14368327 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04079355 0,14346357 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04079355 0,14324454 ! neural plate development GO:0001840 6 5 0,000 0,04079355 0,14302618 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,04079355 0,14280849 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04079355 0,14259145 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04079355 0,14237508 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04079355 0,14215936 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04079355 0,14194429 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04079355 0,14172987 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04079355 0,1415161 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04079355 0,14130298 ! spindle assembly GO:0051225 5 5 0,000 0,04079355 0,14109049 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04079355 0,14087864 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04079355 0,14066743 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04079355 0,14045685 ! organ regeneration GO:0031100 7 5 0,000 0,04079355 0,1402469 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04079355 0,14003758 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04079355 0,13982888 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04079355 0,1396208 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04079355 0,13941334 GO:0055081|anion homeostasis, ! cell fate commitment GO:0045165 141 92 2,000 0,04111872 0,14031611 ! DNA recombination GO:0006310 146 92 2,000 0,04111872 0,14010823 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,04145239 0,14103623 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,04145239 0,1408279 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,04145239 0,14062019 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,04145239 0,14041309 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,04145239 0,1402066 ! male sex differentiation GO:0046661 53 39 1,000 0,04145239 0,14000072 ! JNK cascade GO:0007254 54 39 1,000 0,04145239 0,13979544 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,04223948 0,14224129 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,04223948 0,14203333 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,04340191 0,14572905 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,04340191 0,14551662 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,04340191 0,1453048 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,04340191 0,14509361 ! glucose transport GO:0015758 52 41 1,000 0,04538503 0,15150302 ! striated muscle contraction GO:0006941 62 41 1,000 0,04538503 0,15128345 ! biopolymer methylation GO:0043414 62 41 1,000 0,04538503 0,15106452 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,04538503 0,15084621 ! in utero embryonic development GO:0001701 147 96 2,000 0,04569318 0,15165124 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,04740107 0,15709288 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,04740107 0,15686684 ! hexose transport GO:0008645 54 42 1,000 0,04740107 0,15664146 GO:0015749|monosaccharide transport, ! icosanoid metabolic process GO:0006690 61 42 1,000 0,04740107 0,15641672 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,04740107 0,15619263 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,04740107 0,15596918 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,04740107 0,15574637 ! regulation of cell shape GO:0008360 78 42 1,000 0,04740107 0,15552419 ! tRNA transcription GO:0009304 11 6 0,000 0,04875172 0,15972787 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04875172 0,15950066 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04875172 0,1592741 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04875172 0,15904818 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04875172 0,1588229 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04875172 0,15859825 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04875172 0,15837425 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04875172 0,15815087 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04875172 0,15792812 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04875172 0,157706 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04875172 0,1574845 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04875172 0,15726363 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04875172 0,15704337 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04875172 0,15682373 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04875172 0,1566047 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04875172 0,15638628 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04875172 0,15616848 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04875172 0,15595127 ! neuron adhesion GO:0007158 9 6 0,000 0,04875172 0,15573468 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04875172 0,15551868 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04875172 0,15530328 ! signal peptide processing GO:0006465 8 6 0,000 0,04875172 0,15508847 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04875172 0,15487426 ! mRNA stabilization GO:0048255 15 6 0,000 0,04875172 0,15466064 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04875172 0,15444761 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04875172 0,15423517 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04875172 0,15402331 ! opsonization GO:0008228 8 6 0,000 0,04875172 0,15381203 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04875172 0,15360132 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04875172 0,1533912 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04875172 0,15318165 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04875172 0,15297267 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04875172 0,15276426 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04875172 0,15255642 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04875172 0,15234914 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04875172 0,15214242 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04875172 0,15193627 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04875172 0,15173067 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04875172 0,15152563 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04875172 0,15132114 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04875172 0,15111721 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04875172 0,15091382 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04875172 0,15071098 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04875172 0,15050868 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04875172 0,15030693 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04875172 0,15010571 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04875172 0,14990504 ! thymic T cell selection GO:0045061 12 6 0,000 0,04875172 0,14970489 ! protein lipoylation GO:0009249 10 6 0,000 0,04875172 0,14950529 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04875172 0,14930621 ! drug transport GO:0015893 6 6 0,000 0,04875172 0,14910767 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04875172 0,14890965 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04875172 0,14871216 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04875172 0,14851519 ! histidine metabolic process GO:0006547 6 6 0,000 0,04875172 0,14831874 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04875172 0,14812281 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04875172 0,1479274 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04875172 0,1477325 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04875172 0,14753811 ! adenohypophysis development GO:0021984 10 6 0,000 0,04875172 0,14734424 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04875172 0,14715087 ! microtubule nucleation GO:0007020 10 6 0,000 0,04875172 0,14695802 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04875172 0,14676566 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04875172 0,14657381 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04875172 0,14638246 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04875172 0,14619161 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04875172 0,14600126 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04875172 0,1458114 ! response to dietary excess GO:0002021 7 6 0,000 0,04875172 0,14562203 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04875172 0,14543316 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04875172 0,14524477 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04875172 0,14505688 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04875172 0,14486947 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04875172 0,14468254 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04875172 0,14449609 ! neuron apoptosis GO:0051402 8 6 0,000 0,04875172 0,14431012 ! organic alcohol transport GO:0015850 9 6 0,000 0,04875172 0,14412464 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04875172 0,14393962 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04875172 0,14375508 ! carnitine transport GO:0015879 8 6 0,000 0,04875172 0,14357102 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04875172 0,14338742 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04875172 0,1432043 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04875172 0,14302164 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04875172 0,14283945 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04875172 0,14265772 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04875172 0,14247645 ! parturition GO:0007567 12 6 0,000 0,04875172 0,14229564 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04875172 0,14211529 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04875172 0,1419354 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04875172 0,14175596 ! spindle checkpoint GO:0031577 14 6 0,000 0,04875172 0,14157698 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04875172 0,14139844 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04875172 0,14122036 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04875172 0,14104272 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04875172 0,14086554 ! macrophage differentiation GO:0030225 10 6 0,000 0,04875172 0,14068879 ! astrocyte development GO:0014002 14 6 0,000 0,04875172 0,14051249 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04875172 0,14033663 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04875172 0,14016121 ! interaction with symbiont GO:0051702 8 6 0,000 0,04875172 0,13998623 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04875172 0,13981168 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04875172 0,13963757 ! eating behavior GO:0042755 6 6 0,000 0,04875172 0,13946389 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04875172 0,13929064 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04875172 0,13911782 ! response to copper ion GO:0046688 9 6 0,000 0,04875172 0,13894544 ! DNA topological change GO:0006265 8 6 0,000 0,04875172 0,13877347 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04875172 0,13860194 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04875172 0,13843082 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04875172 0,13826013 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04875172 0,13808986 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04875172 0,13792001 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04875172 0,13775057 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04875172 0,13758155 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04875172 0,13741295 ! gas homeostasis GO:0033483 11 6 0,000 0,04875172 0,13724476 ! hair follicle maturation GO:0048820 7 6 0,000 0,04875172 0,13707698 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04875172 0,1369096 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04875172 0,13674264 ! Schwann cell development GO:0014044 14 6 0,000 0,04875172 0,13657609 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04875172 0,13640993 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04875172 0,13624419 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04875172 0,13607884 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04875172 0,1359139 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04875172 0,13574935 ! histone ubiquitination GO:0016574 7 6 0,000 0,04875172 0,13558521 ! regulation of meiosis GO:0040020 10 6 0,000 0,04875172 0,13542146 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04875172 0,1352581 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04875172 0,13509514 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04875172 0,13493257 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04875172 0,13477039 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04875172 0,1346086 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04875172 0,1344472 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04875172 0,13428619 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04875172 0,13412556 ! receptor internalization GO:0031623 9 6 0,000 0,04875172 0,13396531 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04875172 0,13380545 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04875172 0,13364597 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04875172 0,13348686 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04875172 0,13332814 ! protein deubiquitination GO:0016579 8 6 0,000 0,04875172 0,13316979 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04875172 0,13301182 ! axonal fasciculation GO:0007413 9 6 0,000 0,04875172 0,13285423 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04875172 0,132697 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04875172 0,13254015 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04875172 0,13238367 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04875172 0,13222755 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04875172 0,13207181 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04875172 0,13191643 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04875172 0,13176142 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04875172 0,13160677 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04875172 0,13145248 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04875172 0,13129856 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04875172 0,13114499 ! adult feeding behavior GO:0008343 6 6 0,000 0,04875172 0,13099178 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04875172 0,13083893 ! pigment granule transport GO:0051904 12 6 0,000 0,04875172 0,13068644 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04875172 0,1305343 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04875172 0,13038252 ! catecholamine transport GO:0051937 7 6 0,000 0,04875172 0,13023109 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04875172 0,13008001 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04875172 0,12992928 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04875172 0,1297789 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04875172 0,12962886 ! protein prenylation GO:0018342 10 6 0,000 0,04875172 0,12947918 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04875172 0,12932983 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04875172 0,12918084 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04875172 0,12903218 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04875172 0,12888387 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04875172 0,1287359 ! calcium ion transport GO:0006816 167 99 2,000 0,04928266 0,12998866 ! neuromuscular process GO:0050905 79 43 1,000 0,04944934 0,1302789 ! activation of caspase activity GO:0006919 65 43 1,000 0,04944934 0,13012984 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04944934 0,12998112 ! vesicle organization GO:0016050 79 43 1,000 0,04944934 0,12983274 ! methylation GO:0032259 64 43 1,000 0,04944934 0,1296847 ! regulation of translation GO:0006417 151 100 2,000 0,050509 0,13231288 ! divalent metal ion transport GO:0070838 171 100 2,000 0,050509 0,13216235 ! regulation of action potential GO:0001508 71 44 1,000 0,05152918 0,13467855 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,05152918 0,13452568 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,05363994 0,1398774 ! cell maturation GO:0048469 60 45 1,000 0,05363994 0,13971899 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,05578097 0,14513149 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,05578097 0,1449675 ! regulation of ossification GO:0030278 71 46 1,000 0,05578097 0,14480388 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,05664432 0,1468793 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05664432 0,14671389 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05664432 0,14654886 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05664432 0,1463842 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05664432 0,14621991 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05664432 0,14605598 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05664432 0,14589243 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05664432 0,14572923 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05664432 0,14556641 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05664432 0,14540395 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05664432 0,14524185 ! reproductive behavior GO:0019098 12 7 0,000 0,05664432 0,14508011 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05664432 0,14491873 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,05664432 0,14475771 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05664432 0,14459704 ! oligopeptide transport GO:0006857 11 7 0,000 0,05664432 0,14443674 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05664432 0,14427678 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05664432 0,14411719 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05664432 0,14395794 ! RNA methylation GO:0001510 11 7 0,000 0,05664432 0,14379905 ! pericardium development GO:0060039 8 7 0,000 0,05664432 0,1436405 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05664432 0,14348231 ! fibril organization GO:0043206 13 7 0,000 0,05664432 0,14332446 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05664432 0,14316696 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,05664432 0,14300981 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05664432 0,142853 ! lipoprotein transport GO:0042953 9 7 0,000 0,05664432 0,14269653 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05664432 0,14254041 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05664432 0,14238463 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05664432 0,14222919 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05664432 0,14207409 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05664432 0,14191932 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05664432 0,14176489 ! chemosensory behavior GO:0007635 9 7 0,000 0,05664432 0,1416108 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05664432 0,14145704 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05664432 0,14130362 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05664432 0,14115053 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05664432 0,14099777 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05664432 0,14084534 ! reflex GO:0060004 12 7 0,000 0,05664432 0,14069324 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05664432 0,14054146 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05664432 0,14039002 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05664432 0,1402389 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05664432 0,1400881 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05664432 0,13993763 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05664432 0,13978748 ! spinal cord patterning GO:0021511 7 7 0,000 0,05664432 0,13963766 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05664432 0,13948815 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05664432 0,13933897 ! adrenal gland development GO:0030325 17 7 0,000 0,05664432 0,1391901 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05664432 0,13904155 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05664432 0,13889332 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05664432 0,13874541 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05664432 0,1385978 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05664432 0,13845052 ! endosome organization GO:0007032 10 7 0,000 0,05664432 0,13830354 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05664432 0,13815688 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05664432 0,13801053 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05664432 0,13786448 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05664432 0,13771875 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05664432 0,13757332 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05664432 0,1374282 ! galactose metabolic process GO:0006012 10 7 0,000 0,05664432 0,13728339 ! vesicle fusion GO:0006906 15 7 0,000 0,05664432 0,13713888 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05664432 0,13699468 GO:0045851|pH reduction, ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05664432 0,13685077 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05664432 0,13670717 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05664432 0,13656387 ! retinol metabolic process GO:0042572 9 7 0,000 0,05664432 0,13642088 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05664432 0,13627818 ! rRNA modification GO:0000154 12 7 0,000 0,05664432 0,13613577 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05664432 0,13599367 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05664432 0,13585186 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05664432 0,13571035 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05664432 0,13556913 ! fibrinolysis GO:0042730 9 7 0,000 0,05664432 0,13542821 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05664432 0,13528758 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05664432 0,13514724 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05664432 0,13500719 ! response to tropane GO:0014073 13 7 0,000 0,05664432 0,13486743 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05664432 0,13472796 ! melanosome localization GO:0032400 10 7 0,000 0,05664432 0,13458878 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05664432 0,13444988 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05664432 0,13431127 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05664432 0,13417295 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05664432 0,13403491 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05664432 0,13389716 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05664432 0,13375969 ! mast cell activation GO:0045576 9 7 0,000 0,05664432 0,1336225 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05664432 0,13348559 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05664432 0,13334896 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05664432 0,13321261 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05664432 0,13307654 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05664432 0,13294075 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05664432 0,13280524 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05664432 0,13267 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05664432 0,13253503 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05664432 0,13240034 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05664432 0,13226592 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05664432 0,13213178 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05664432 0,13199791 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05664432 0,13186431 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05664432 0,13173098 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05664432 0,13159792 ! diuresis GO:0030146 12 7 0,000 0,05664432 0,13146512 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05664432 0,1313326 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05664432 0,13120034 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05664432 0,13106835 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05664432 0,13093662 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05664432 0,13080516 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05664432 0,13067396 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05664432 0,13054302 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05664432 0,13041235 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05664432 0,13028194 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05664432 0,13015178 ! lymph node development GO:0048535 9 7 0,000 0,05664432 0,13002189 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05664432 0,12989226 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05664432 0,12976288 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05664432 0,12963377 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05664432 0,12950491 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05664432 0,1293763 ! ATP catabolic process GO:0006200 10 7 0,000 0,05664432 0,12924795 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05664432 0,12911986 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05664432 0,12899202 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05664432 0,12886443 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05664432 0,12873709 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05664432 0,12861001 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05664432 0,12848317 ! muscle adaptation GO:0043500 12 7 0,000 0,05664432 0,12835659 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05664432 0,12823025 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05664432 0,12810417 ! retina homeostasis GO:0001895 9 7 0,000 0,05664432 0,12797833 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05664432 0,12785273 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05664432 0,12772739 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05664432 0,12760229 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05664432 0,12747743 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05664432 0,12735282 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05664432 0,12722845 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05664432 0,12710433 ! chloride transport GO:0006821 67 48 1,000 0,06015128 0,13484206 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,06015128 0,13471076 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,06015128 0,13457972 ! gastrulation GO:0007369 73 48 1,000 0,06015128 0,13444893 ! heart morphogenesis GO:0003007 65 48 1,000 0,06015128 0,1343184 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,06015128 0,13418812 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,06237931 0,13902366 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,06237931 0,13888908 ! maintenance of location GO:0051235 84 49 1,000 0,06237931 0,13875475 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06447188 0,14327084 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06447188 0,14313255 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,06447188 0,14299452 ! axon extension GO:0048675 11 8 0,000 0,06447188 0,14285676 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,06447188 0,14271927 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06447188 0,14258204 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06447188 0,14244507 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06447188 0,14230837 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06447188 0,14217193 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06447188 0,14203575 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,06447188 0,14189983 ! phosphate transport GO:0006817 10 8 0,000 0,06447188 0,14176417 ! N-glycan processing GO:0006491 12 8 0,000 0,06447188 0,14162877 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06447188 0,14149363 ! UTP metabolic process GO:0046051 8 8 0,000 0,06447188 0,14135874 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06447188 0,14122411 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06447188 0,14108974 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06447188 0,14095563 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,06447188 0,14082177 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,06447188 0,14068816 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06447188 0,1405548 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,06447188 0,1404217 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06447188 0,14028885 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,06447188 0,14015626 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06447188 0,14002391 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06447188 0,13989181 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06447188 0,13975996 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06447188 0,13962836 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06447188 0,13949701 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06447188 0,1393659 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06447188 0,13923504 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06447188 0,13910443 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06447188 0,13897406 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06447188 0,13884393 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06447188 0,13871405 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06447188 0,13858441 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06447188 0,13845501 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06447188 0,13832586 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06447188 0,13819694 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06447188 0,13806827 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06447188 0,13793983 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06447188 0,13781163 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,06447188 0,13768368 ! macrophage activation GO:0042116 12 8 0,000 0,06447188 0,13755595 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06447188 0,13742847 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06447188 0,13730122 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06447188 0,13717421 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,06447188 0,13704743 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06447188 0,13692089 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06447188 0,13679457 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06447188 0,1366685 ! ruffle organization GO:0031529 11 8 0,000 0,06447188 0,13654265 ! osteoblast development GO:0002076 13 8 0,000 0,06447188 0,13641704 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06447188 0,13629165 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06447188 0,1361665 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06447188 0,13604158 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06447188 0,13591688 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06447188 0,13579242 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06447188 0,13566818 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,06447188 0,13554417 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06447188 0,13542038 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06447188 0,13529682 ! brain morphogenesis GO:0048854 20 8 0,000 0,06447188 0,13517349 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06447188 0,13505038 ! segment specification GO:0007379 10 8 0,000 0,06447188 0,1349275 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,06447188 0,13480484 ! cellular extravasation GO:0045123 11 8 0,000 0,06447188 0,1346824 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06447188 0,13456018 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06447188 0,13443819 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06447188 0,13431641 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,06447188 0,13419486 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06447188 0,13407353 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06447188 0,13395241 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,06447188 0,13383152 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06447188 0,13371084 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06447188 0,13359038 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06447188 0,13347013 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06447188 0,13335011 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06447188 0,1332303 ! icosanoid secretion GO:0032309 12 8 0,000 0,06447188 0,1331107 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,06447188 0,13299132 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06447188 0,13287215 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06447188 0,1327532 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06447188 0,13263445 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06447188 0,13251592 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06447188 0,13239761 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06447188 0,1322795 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06447188 0,1321616 ! sterol catabolic process GO:0016127 9 8 0,000 0,06447188 0,13204392 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06447188 0,13192644 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06447188 0,13180917 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06447188 0,13169211 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06447188 0,13157526 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06447188 0,13145862 ! prophase GO:0051324 11 8 0,000 0,06447188 0,13134218 ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06447188 0,13122595 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,06447188 0,13110992 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06447188 0,1309941 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06447188 0,13087848 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06447188 0,13076307 ! hormone catabolic process GO:0042447 13 8 0,000 0,06447188 0,13064786 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06447188 0,13053285 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,06447188 0,13041805 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06447188 0,13030344 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06447188 0,13018904 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06447188 0,13007484 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,06447188 0,12996084 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06447188 0,12984704 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06447188 0,12973344 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06447188 0,12962003 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06447188 0,12950683 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06447188 0,12939382 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06447188 0,12928101 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06447188 0,1291684 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06447188 0,12905598 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,06447188 0,12894376 ! ear development GO:0043583 72 50 1,000 0,0646351 0,12915789 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,0646351 0,12904577 ! lipid modification GO:0030258 73 50 1,000 0,0646351 0,12893385 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 0,06691804 0,13337219 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,06691804 0,13325671 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,07156301 0,14238315 ! kidney development GO:0001822 90 53 1,000 0,07156301 0,14226009 ! cell projection assembly GO:0030031 76 53 1,000 0,07156301 0,14213724 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,07223493 0,14334801 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07223493 0,14322443 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,07223493 0,14310107 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07223493 0,14297792 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07223493 0,14285498 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,07223493 0,14273225 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,07223493 0,14260973 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,07223493 0,14248743 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,07223493 0,14236533 ! GTP metabolic process GO:0046039 9 9 0,000 0,07223493 0,14224344 ! elastic fiber assembly GO:0048251 13 9 0,000 0,07223493 0,14212176 ! social behavior GO:0035176 14 9 0,000 0,07223493 0,14200029 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,07223493 0,14187903 ! artery development GO:0060840 19 9 0,000 0,07223493 0,14175797 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,07223493 0,14163712 ! response to pain GO:0048265 16 9 0,000 0,07223493 0,14151647 ! protein complex disassembly GO:0043241 17 9 0,000 0,07223493 0,14139603 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,07223493 0,1412758 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,07223493 0,14115577 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,07223493 0,14103594 ! lung alveolus development GO:0048286 17 9 0,000 0,07223493 0,14091632 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07223493 0,1407969 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,07223493 0,14067768 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07223493 0,14055866 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,07223493 0,14043985 ! ventral spinal cord development GO:0021517 11 9 0,000 0,07223493 0,14032123 ! protein targeting to ER GO:0045047 19 9 0,000 0,07223493 0,14020282 ! endoderm development GO:0007492 12 9 0,000 0,07223493 0,1400846 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07223493 0,13996659 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07223493 0,13984877 ! arginine catabolic process GO:0006527 10 9 0,000 0,07223493 0,13973115 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,07223493 0,13961373 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,07223493 0,13949651 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,07223493 0,13937948 ! V(D)J recombination GO:0033151 12 9 0,000 0,07223493 0,13926265 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07223493 0,13914601 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,07223493 0,13902957 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07223493 0,13891333 ! mannose metabolic process GO:0006013 9 9 0,000 0,07223493 0,13879728 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,07223493 0,13868142 ! receptor clustering GO:0043113 15 9 0,000 0,07223493 0,13856575 ! epithelial cell development GO:0002064 10 9 0,000 0,07223493 0,13845028 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07223493 0,138335 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07223493 0,13821992 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,07223493 0,13810502 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07223493 0,13799032 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07223493 0,1378758 ! motor axon guidance GO:0008045 14 9 0,000 0,07223493 0,13776148 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,07223493 0,13764734 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07223493 0,13753339 ! blastoderm segmentation GO:0007350 11 9 0,000 0,07223493 0,13741964 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,07223493 0,13730607 ! DNA ligation GO:0006266 14 9 0,000 0,07223493 0,13719268 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07223493 0,13707949 ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07223493 0,13696648 ! erythrocyte development GO:0048821 11 9 0,000 0,07223493 0,13685366 ! renal water homeostasis GO:0003091 14 9 0,000 0,07223493 0,13674102 ! postreplication repair GO:0006301 11 9 0,000 0,07223493 0,13662857 ! mRNA cleavage GO:0006379 13 9 0,000 0,07223493 0,1365163 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,07223493 0,13640422 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,07223493 0,13629232 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,07223493 0,13618061 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07223493 0,13606907 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,07223493 0,13595772 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07223493 0,13584656 ! acid secretion GO:0046717 14 9 0,000 0,07223493 0,13573557 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07223493 0,13562477 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07223493 0,13551414 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07223493 0,1354037 ! purine base metabolic process GO:0006144 18 9 0,000 0,07223493 0,13529344 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07223493 0,13518335 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,07223493 0,13507345 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07223493 0,13496372 ! detection of calcium ion GO:0005513 13 9 0,000 0,07223493 0,13485417 ! blastocyst formation GO:0001825 12 9 0,000 0,07223493 0,1347448 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07223493 0,13463561 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07223493 0,13452659 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07223493 0,13441775 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,07223493 0,13430909 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07223493 0,1342006 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07223493 0,13409228 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,07223493 0,13398414 ! prepulse inhibition GO:0060134 14 9 0,000 0,07223493 0,13387618 ! embryonic placenta development GO:0001892 12 9 0,000 0,07223493 0,13376839 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,07223493 0,13366077 ! insulin secretion GO:0030073 17 9 0,000 0,07223493 0,13355333 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07223493 0,13344606 ! nucleus localization GO:0051647 15 9 0,000 0,07223493 0,13333896 ! regulation of synapse organization GO:0050807 12 9 0,000 0,07223493 0,13323203 ! localization within membrane GO:0051668 15 9 0,000 0,07223493 0,13312527 ! amino acid transport GO:0006865 84 54 1,000 0,07392385 0,1361288 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,07392385 0,13601989 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,07392385 0,13591116 ! exocytosis GO:0006887 74 55 1,000 0,07630951 0,1401852 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07993401 0,14672643 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07993401 0,14660942 ! neuron fate specification GO:0048665 11 10 0,000 0,07993401 0,1464926 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07993401 0,14637596 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07993401 0,14625952 ! thyroid gland development GO:0030878 19 10 0,000 0,07993401 0,14614325 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,07993401 0,14602717 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07993401 0,14591128 ! synapsis GO:0007129 13 10 0,000 0,07993401 0,14579557 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07993401 0,14568004 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07993401 0,1455647 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07993401 0,14544953 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,07993401 0,14533455 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07993401 0,14521976 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07993401 0,14510514 ! androgen metabolic process GO:0008209 13 10 0,000 0,07993401 0,1449907 ! phospholipid efflux GO:0033700 16 10 0,000 0,07993401 0,14487645 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,07993401 0,14476237 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07993401 0,14464848 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07993401 0,14453476 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07993401 0,14442122 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,07993401 0,14430786 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07993401 0,14419468 ! pathogenesis GO:0009405 13 10 0,000 0,07993401 0,14408167 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07993401 0,14396884 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07993401 0,14385619 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07993401 0,14374372 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,07993401 0,14363142 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07993401 0,14351929 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07993401 0,14340734 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07993401 0,14329557 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07993401 0,14318397 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07993401 0,14307254 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07993401 0,14296128 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07993401 0,1428502 ! forebrain cell migration GO:0021885 17 10 0,000 0,07993401 0,14273929 ! lipid digestion GO:0044241 15 10 0,000 0,07993401 0,14262856 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07993401 0,14251799 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07993401 0,1424076 ! UV protection GO:0009650 14 10 0,000 0,07993401 0,14229738 ! entry into host cell GO:0030260 20 10 0,000 0,07993401 0,14218733 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07993401 0,14207744 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07993401 0,14196773 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07993401 0,14185819 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07993401 0,14174881 ! regulation of organ growth GO:0046620 11 10 0,000 0,07993401 0,14163961 ! response to dsRNA GO:0043331 18 10 0,000 0,07993401 0,14153057 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07993401 0,1414217 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07993401 0,141313 ! embryonic axis specification GO:0000578 12 10 0,000 0,07993401 0,14120446 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07993401 0,1410961 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07993401 0,14098789 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07993401 0,14087986 ! cranial nerve development GO:0021545 12 10 0,000 0,07993401 0,14077198 ! fucose catabolic process GO:0019317 16 10 0,000 0,07993401 0,14066428 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07993401 0,14055674 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07993401 0,14044936 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07993401 0,14034215 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07993401 0,1402351 ! zymogen activation GO:0031638 14 10 0,000 0,07993401 0,14012821 ! salivary gland development GO:0007431 22 10 0,000 0,07993401 0,14002149 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07993401 0,13991493 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07993401 0,13980853 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07993401 0,13970229 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07993401 0,13959621 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07993401 0,1394903 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07993401 0,13938454 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07993401 0,13927895 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07993401 0,13917351 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07993401 0,13906824 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07993401 0,13896312 ! detection of bacterium GO:0016045 10 10 0,000 0,07993401 0,13885817 ! embryonic gut development GO:0048566 11 10 0,000 0,07993401 0,13875337 ! activation of innate immune response GO:0002218 10 10 0,000 0,07993401 0,13864873 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07993401 0,13854424 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07993401 0,13843992 ! developmental induction GO:0031128 13 10 0,000 0,07993401 0,13833575 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07993401 0,13823174 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07993401 0,13812788 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07993401 0,13802418 ! carbohydrate transport GO:0008643 74 57 1,000 0,08115298 0,1400239 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,08115298 0,13991893 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,08115298 0,13981412 ! secondary metabolic process GO:0019748 84 57 1,000 0,08115298 0,13970947 ! developmental maturation GO:0021700 75 57 1,000 0,08115298 0,13960498 ! viral reproductive process GO:0022415 87 58 1,000 0,08360968 0,14372367 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,08360968 0,14361633 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,08360968 0,14350916 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,08608897 0,14765446 ! lung development GO:0030324 94 59 1,000 0,08608897 0,14754444 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,08608897 0,14743458 ! rRNA transcription GO:0009303 17 11 0,000 0,08756963 0,14985874 ! respiratory burst GO:0045730 14 11 0,000 0,08756963 0,14974732 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08756963 0,14963606 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08756963 0,14952497 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,08756963 0,14941405 ! filopodium assembly GO:0046847 19 11 0,000 0,08756963 0,14930329 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08756963 0,1491927 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08756963 0,14908226 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,08756963 0,148972 ! mating GO:0007618 14 11 0,000 0,08756963 0,14886189 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,08756963 0,14875195 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08756963 0,14864217 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,08756963 0,14853255 ! bone resorption GO:0045453 16 11 0,000 0,08756963 0,1484231 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08756963 0,1483138 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08756963 0,14820467 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,08756963 0,14809569 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,08756963 0,14798688 ! syncytium formation GO:0006949 15 11 0,000 0,08756963 0,14787822 ! plasma membrane organization GO:0007009 18 11 0,000 0,08756963 0,14776973 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08756963 0,14766139 ! mitotic spindle organization GO:0007052 15 11 0,000 0,08756963 0,14755322 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08756963 0,1474452 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08756963 0,14733734 ! adult heart development GO:0007512 11 11 0,000 0,08756963 0,14722963 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,08756963 0,14712209 ! temperature homeostasis GO:0001659 16 11 0,000 0,08756963 0,1470147 ! L-glutamate transport GO:0015813 16 11 0,000 0,08756963 0,14690747 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,08756963 0,14680039 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08756963 0,14669347 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08756963 0,14658671 ! stem cell development GO:0048864 29 11 0,000 0,08756963 0,1464801 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08756963 0,14637365 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08756963 0,14626735 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08756963 0,1461612 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08756963 0,14605521 ! vasoconstriction GO:0042310 15 11 0,000 0,08756963 0,14594938 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08756963 0,14584369 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08756963 0,14573816 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08756963 0,14563278 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08756963 0,14552756 ! ribosome assembly GO:0042255 13 11 0,000 0,08756963 0,14542248 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08756963 0,14531756 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08756963 0,14521279 ! chromatin silencing GO:0006342 19 11 0,000 0,08756963 0,14510817 ! nucleosome positioning GO:0016584 13 11 0,000 0,08756963 0,1450037 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08756963 0,14489938 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,08756963 0,14479521 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08756963 0,14469119 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08756963 0,14458732 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08756963 0,1444836 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08756963 0,14438003 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08756963 0,1442766 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08756963 0,14417333 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08756963 0,1440702 ! male genitalia development GO:0030539 13 11 0,000 0,08756963 0,14396722 ! cholesterol efflux GO:0033344 19 11 0,000 0,08756963 0,14386439 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08756963 0,1437617 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08756963 0,14365916 ! germ cell migration GO:0008354 18 11 0,000 0,08756963 0,14355676 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08756963 0,14345452 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,08756963 0,14335241 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,08756963 0,14325046 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08756963 0,14314864 ! lysogeny GO:0030069 18 11 0,000 0,08756963 0,14304697 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08756963 0,14294545 ! acrosome reaction GO:0007340 13 11 0,000 0,08756963 0,14284407 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08756963 0,14274283 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,08859031 0,14430432 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,08859031 0,1442022 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,09111316 0,14820386 ! meiosis GO:0007126 96 61 1,000 0,09111316 0,14809913 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 1,000 0,09111316 0,14799454 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,09111316 0,14789009 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,09111316 0,1477858 ! respiratory tube development GO:0030323 99 62 1,000 0,093657 0,15180487 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,093657 0,15169796 ! meiotic cell cycle GO:0051321 97 62 1,000 0,093657 0,15159121 ! lactation GO:0007595 20 12 0,000 0,09514231 0,153887 ! reproductive cellular process GO:0048610 14 12 0,000 0,09514231 0,15377886 ! tRNA modification GO:0006400 14 12 0,000 0,09514231 0,15367087 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,09514231 0,15356303 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,09514231 0,15345534 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,09514231 0,15334781 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,09514231 0,15324042 ! non-recombinational repair GO:0000726 19 12 0,000 0,09514231 0,15313318 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,09514231 0,1530261 ! peroxisomal transport GO:0043574 21 12 0,000 0,09514231 0,15291916 ! cartilage condensation GO:0001502 18 12 0,000 0,09514231 0,15281237 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,09514231 0,15270574 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,09514231 0,15259925 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,09514231 0,15249291 ! heart looping GO:0001947 15 12 0,000 0,09514231 0,15238671 ! palate development GO:0060021 15 12 0,000 0,09514231 0,15228067 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,09514231 0,15217477 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,09514231 0,15206902 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,09514231 0,15196342 ! arginine metabolic process GO:0006525 13 12 0,000 0,09514231 0,15185796 ! methionine metabolic process GO:0006555 13 12 0,000 0,09514231 0,15175265 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,09514231 0,15164748 ! Golgi organization GO:0007030 18 12 0,000 0,09514231 0,15154246 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,09514231 0,15143759 ! monoamine transport GO:0015844 13 12 0,000 0,09514231 0,15133286 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,09514231 0,15122828 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,09514231 0,15112384 ! L-amino acid transport GO:0015807 20 12 0,000 0,09514231 0,15101954 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,09514231 0,15091539 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,09514231 0,15081138 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,09514231 0,15070752 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,09514231 0,1506038 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,09514231 0,15050022 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,09514231 0,15039678 ! cerebellum development GO:0021549 13 12 0,000 0,09514231 0,15029349 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,09514231 0,15019034 ! autonomic nervous system development GO:0048483 23 12 0,000 0,09514231 0,15008732 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,09514231 0,14998445 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,09514231 0,14988173 ! regulation of epidermis development GO:0045682 17 12 0,000 0,09514231 0,14977914 ! intestinal absorption GO:0050892 19 12 0,000 0,09514231 0,14967669 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,09514231 0,14957438 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,09514231 0,14947221 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,09514231 0,14937018 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,09514231 0,14926829 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,09514231 0,14916654 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,09514231 0,14906493 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,09514231 0,14896346 ! microspike assembly GO:0030035 23 12 0,000 0,09514231 0,14886212 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,09514231 0,14876092 ! response to cold GO:0009409 14 12 0,000 0,09514231 0,14865986 ! viral reproduction GO:0016032 92 63 1,000 0,09622133 0,15024375 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,09880562 0,1541743 ! respiratory system development GO:0060541 100 64 1,000 0,09880562 0,15406978 ! regulation of caspase activity GO:0043281 97 65 1,000 0,10140938 0,15802274 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,10140938 0,15791575 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,10140938 0,15780891 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,10140938 0,15770221 ! activation of immune response GO:0002253 83 65 1,000 0,10140938 0,15759565 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,10265258 0,15941994 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,10265258 0,15931237 ! cGMP metabolic process GO:0046068 16 13 0,000 0,10265258 0,15920494 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,10265258 0,15909766 ! water transport GO:0006833 17 13 0,000 0,10265258 0,15899053 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,10265258 0,15888353 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,10265258 0,15877669 ! lipid localization GO:0010876 24 13 0,000 0,10265258 0,15866998 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,10265258 0,15856342 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,10265258 0,158457 ! organelle fusion GO:0048284 28 13 0,000 0,10265258 0,15835073 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,10265258 0,15824459 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,10265258 0,1581386 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,10265258 0,15803275 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,10265258 0,15792705 ! response to hexose stimulus GO:0009746 19 13 0,000 0,10265258 0,15782148 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,10265258 0,15771605 ! glutamate metabolic process GO:0006536 18 13 0,000 0,10265258 0,15761077 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,10265258 0,15750563 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,10265258 0,15740062 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,10265258 0,15729576 ! NAD metabolic process GO:0019674 21 13 0,000 0,10265258 0,15719103 ! exocrine system development GO:0035272 27 13 0,000 0,10265258 0,15708645 ! bone mineralization GO:0030282 15 13 0,000 0,10265258 0,156982 ! regulation of exocytosis GO:0017157 17 13 0,000 0,10265258 0,1568777 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,10265258 0,15677353 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,10265258 0,1566695 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,10265258 0,15656561 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,10265258 0,15646185 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,10265258 0,15635823 ! genitalia development GO:0048806 15 13 0,000 0,10265258 0,15625475 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,10265258 0,15615141 ! tissue regeneration GO:0042246 21 13 0,000 0,10265258 0,1560482 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,10265258 0,15594513 ! cofactor transport GO:0051181 19 13 0,000 0,10265258 0,1558422 ! NADP metabolic process GO:0006739 18 13 0,000 0,10265258 0,1557394 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,10265258 0,15563674 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,10265258 0,15553421 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,10265258 0,15543182 ! gas transport GO:0015669 18 13 0,000 0,10265258 0,15532956 ! regulation of RNA stability GO:0043487 28 13 0,000 0,10265258 0,15522744 ! heme biosynthetic process GO:0006783 20 13 0,000 0,10265258 0,15512545 ! regulation of axon extension GO:0030516 23 13 0,000 0,10265258 0,15502359 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,10265258 0,15492187 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,10265258 0,15482028 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,10265258 0,15471883 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,10265258 0,15461751 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,10265258 0,15451632 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,10403211 0,15649041 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,10667332 0,16035859 ! rhythmic process GO:0048511 105 68 1,000 0,10933254 0,16424875 ! inorganic anion transport GO:0015698 93 68 1,000 0,10933254 0,16414154 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,11010094 0,16518732 ! superoxide anion generation GO:0042554 18 14 0,000 0,11010094 0,16507963 ! neuron maturation GO:0042551 21 14 0,000 0,11010094 0,16497209 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,11010094 0,16486469 ! myotube differentiation GO:0014902 21 14 0,000 0,11010094 0,16475742 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,11010094 0,1646503 ! inositol metabolic process GO:0006020 20 14 0,000 0,11010094 0,16454331 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,11010094 0,16443647 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,11010094 0,16432976 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,11010094 0,16422319 ! gene silencing by RNA GO:0031047 20 14 0,000 0,11010094 0,16411676 ! response to cAMP GO:0051591 19 14 0,000 0,11010094 0,16401046 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,11010094 0,16390431 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,11010094 0,16379829 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,11010094 0,16369241 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,11010094 0,16358667 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,11010094 0,16348106 ! glycine metabolic process GO:0006544 22 14 0,000 0,11010094 0,16337559 ! pituitary gland development GO:0021983 23 14 0,000 0,11010094 0,16327025 ! lysosomal transport GO:0007041 20 14 0,000 0,11010094 0,16316505 ! regulation of heart rate GO:0002027 23 14 0,000 0,11010094 0,16305999 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,11010094 0,16295506 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,11010094 0,16285026 ! embryo implantation GO:0007566 27 14 0,000 0,11010094 0,1627456 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,11010094 0,16264108 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,11010094 0,16253669 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,11010094 0,16243243 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,11010094 0,16232831 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,11010094 0,16222432 ! mRNA splice site selection GO:0006376 26 14 0,000 0,11010094 0,16212046 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,11010094 0,16201674 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,11010094 0,16191314 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,11010094 0,16180969 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,11010094 0,16170636 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,11010094 0,16160316 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,11010094 0,1615001 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,11010094 0,16139717 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,11010094 0,16129437 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,11010094 0,1611917 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,11010094 0,16108916 ! cell killing GO:0001906 20 14 0,000 0,11010094 0,16098675 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,11010094 0,16088447 ! cilium assembly GO:0042384 20 14 0,000 0,11010094 0,16078232 ! peptide hormone secretion GO:0030072 23 14 0,000 0,11010094 0,1606803 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,11200928 0,16336166 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,11200928 0,16325814 ! response to metal ion GO:0010038 103 70 1,000 0,11470308 0,16707858 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,11470308 0,16697284 ! humoral immune response GO:0006959 86 70 1,000 0,11470308 0,16686723 ! amine transport GO:0015837 101 70 1,000 0,11470308 0,16676175 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,11741348 0,17059444 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,1174879 0,1705948 ! positive regulation of cell size GO:0045793 20 15 0,000 0,1174879 0,17048717 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,1174879 0,17037967 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,1174879 0,17027231 ! skin development GO:0043588 25 15 0,000 0,1174879 0,17016509 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,1174879 0,170058 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,1174879 0,16995104 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,1174879 0,16984422 ! bile acid metabolic process GO:0008206 22 15 0,000 0,1174879 0,16973754 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,1174879 0,16963098 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,1174879 0,16952457 ! adult walking behavior GO:0007628 25 15 0,000 0,1174879 0,16941828 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,1174879 0,16931213 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,1174879 0,16920611 ! myoblast differentiation GO:0045445 27 15 0,000 0,1174879 0,16910022 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,1174879 0,16899447 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,1174879 0,16888885 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,1174879 0,16878336 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,1174879 0,168678 ! cerebral cortex development GO:0021987 29 15 0,000 0,1174879 0,16857278 ! vesicle coating GO:0006901 25 15 0,000 0,1174879 0,16846768 ! DNA integration GO:0015074 22 15 0,000 0,1174879 0,16836272 ! peptide secretion GO:0002790 27 15 0,000 0,1174879 0,16825788 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,1174879 0,16815318 ! regulation of vasodilation GO:0042312 24 15 0,000 0,1174879 0,16804861 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,1174879 0,16794416 ! neuron recognition GO:0008038 22 15 0,000 0,1174879 0,16783985 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,1174879 0,16773567 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,1174879 0,16763161 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,1174879 0,16752769 ! biomineral formation GO:0031214 18 15 0,000 0,1174879 0,16742389 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,1174879 0,16732022 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,1174879 0,16721668 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,1174879 0,16711327 ! organic cation transport GO:0015695 19 15 0,000 0,1174879 0,16700999 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,1174879 0,16690683 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,1174879 0,1668038 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 19 15 0,000 0,1174879 0,1667009 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,12014002 0,17035884 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,12014002 0,17025388 ! protein secretion GO:0009306 27 16 0,000 0,12481395 0,17676853 ! hormone secretion GO:0046879 25 16 0,000 0,12481395 0,17665975 ! bone remodeling GO:0046849 24 16 0,000 0,12481395 0,1765511 ! endothelial cell migration GO:0043542 22 16 0,000 0,12481395 0,17644259 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,12481395 0,17633421 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,12481395 0,17622596 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,12481395 0,17611785 ! glial cell development GO:0021782 24 16 0,000 0,12481395 0,17600987 ! patterning of blood vessels GO:0001569 24 16 0,000 0,12481395 0,17590202 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,12481395 0,1757943 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,12481395 0,17568671 ! protein polyubiquitination GO:0000209 26 16 0,000 0,12481395 0,17557926 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,12481395 0,17547194 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,12481395 0,17536475 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,12481395 0,17525769 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,12481395 0,17515076 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,12481395 0,17504396 ! protein export from nucleus GO:0006611 24 16 0,000 0,12481395 0,17493729 ! negative regulation of immune response GO:0050777 28 16 0,000 0,12481395 0,17483075 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,12481395 0,17472434 ! DNA replication initiation GO:0006270 25 16 0,000 0,12481395 0,17461806 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,12481395 0,17451191 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,12481395 0,17440589 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,12481395 0,1743 ! diencephalon development GO:0021536 25 16 0,000 0,12481395 0,17419423 ! neural crest cell migration GO:0001755 24 16 0,000 0,12481395 0,17408859 ! G1 phase GO:0051318 27 16 0,000 0,12481395 0,17398309 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,12481395 0,17387771 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,12481395 0,17377245 ! steroid catabolic process GO:0006706 22 16 0,000 0,12481395 0,17366733 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,12481395 0,17356233 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,12481395 0,17345746 ! sperm-egg recognition GO:0035036 16 16 0,000 0,12481395 0,17335271 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,12481395 0,17324809 ! nerve development GO:0021675 18 16 0,000 0,12481395 0,1731436 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,12481395 0,17303924 ! negative regulation of translation GO:0017148 22 16 0,000 0,12481395 0,172935 ! protein import into nucleus GO:0006606 118 74 1,000 0,12563973 0,17397434 ! response to inorganic substance GO:0010035 115 75 1,000 0,12841202 0,17770616 ! regulation of ligase activity GO:0051340 114 75 1,000 0,12841202 0,1775993 ! nuclear import GO:0051170 121 75 1,000 0,12841202 0,17749257 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,13119869 0,18123543 ! regulation of protein transport GO:0051223 114 76 1,000 0,13119869 0,18112664 GO:0070201|regulation of establishment of protein localization, ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,13207961 0,18223342 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,13207961 0,18212416 ! negative regulation of defense response GO:0031348 19 17 0,000 0,13207961 0,18201504 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,13207961 0,18190605 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,13207961 0,18179719 ! glycerol metabolic process GO:0006071 20 17 0,000 0,13207961 0,18168846 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,13207961 0,18157986 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,13207961 0,18147139 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,13207961 0,18136305 ! signal complex assembly GO:0007172 29 17 0,000 0,13207961 0,18125484 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,13207961 0,18114675 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,13207961 0,1810388 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,13207961 0,18093097 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,13207961 0,18082328 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,13207961 0,18071571 ! keratinization GO:0031424 17 17 0,000 0,13207961 0,18060827 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,13207961 0,18050095 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,13207961 0,18039377 ! retinoid metabolic process GO:0001523 22 17 0,000 0,13207961 0,18028671 GO:0016101|diterpenoid metabolic process, ! DNA duplex unwinding GO:0032508 25 17 0,000 0,13207961 0,18017978 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,13207961 0,18007297 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,13207961 0,17996629 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,13207961 0,17985974 ! membrane budding GO:0006900 29 17 0,000 0,13207961 0,17975332 ! heme metabolic process GO:0042168 27 17 0,000 0,13207961 0,17964702 ! neuromuscular junction development GO:0007528 23 17 0,000 0,13207961 0,17954084 ! body fluid secretion GO:0007589 27 17 0,000 0,13207961 0,17943479 ! stem cell differentiation GO:0048863 36 17 0,000 0,13207961 0,17932887 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,13207961 0,17922307 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,13207961 0,1791174 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,13207961 0,17901185 ! sensory perception of pain GO:0019233 23 17 0,000 0,13207961 0,17890642 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,13207961 0,17880112 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,13207961 0,17869594 ! synaptogenesis GO:0007416 24 17 0,000 0,13207961 0,17859089 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,13207961 0,17848596 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,13207961 0,17838115 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,13207961 0,17827647 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,13207961 0,17817191 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,13207961 0,17806747 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,13207961 0,17796315 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,13207961 0,17785896 ! protein ubiquitination GO:0016567 125 77 1,000 0,13399932 0,18033846 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,13399932 0,180233 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,13399932 0,18012766 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,13399932 0,18002245 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,13928536 0,18701479 ! positive regulation of translation GO:0045727 28 18 0,000 0,13928536 0,18690568 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,13928536 0,1867967 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,13928536 0,18668784 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,13928536 0,18657911 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,13928536 0,18647051 ! cAMP metabolic process GO:0046058 33 18 0,000 0,13928536 0,18636203 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,13928536 0,18625368 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,13928536 0,18614546 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,13928536 0,18603736 ! axis specification GO:0009798 26 18 0,000 0,13928536 0,18592939 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,13928536 0,18582154 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,13928536 0,18571382 ! pancreas development GO:0031016 26 18 0,000 0,13928536 0,18560622 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,13928536 0,18549875 ! glutamine metabolic process GO:0006541 23 18 0,000 0,13928536 0,1853914 ! response to retinoic acid GO:0032526 25 18 0,000 0,13928536 0,18528417 ! pigmentation during development GO:0048066 31 18 0,000 0,13928536 0,18517707 ! central nervous system neuron development GO:0021954 30 18 0,000 0,13928536 0,18507009 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,13928536 0,18496324 ! fucose metabolic process GO:0006004 26 18 0,000 0,13928536 0,18485651 ! response to fungus GO:0009620 19 18 0,000 0,13928536 0,1847499 ! peptide cross-linking GO:0018149 31 18 0,000 0,13928536 0,18464342 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,13928536 0,18453706 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,13928536 0,18443082 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,13928536 0,1843247 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,13928536 0,18421871 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,13928536 0,18411284 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,13928536 0,18400708 ! vitamin transport GO:0051180 24 18 0,000 0,13928536 0,18390145 ! hormone transport GO:0009914 27 18 0,000 0,13928536 0,18379595 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,13928536 0,18369056 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,13928536 0,18358529 ! cell-cell recognition GO:0009988 20 18 0,000 0,13928536 0,18348015 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,13928536 0,18337512 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,13928536 0,18327021 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,13928536 0,18316543 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,13928536 0,18306076 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,14248078 0,18715351 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,14248078 0,18704669 ! forebrain development GO:0030900 131 80 1,000 0,14248078 0,18693999 ! response to protein stimulus GO:0051789 111 81 1,000 0,14533311 0,19057363 ! regulation of neurological system process GO:0031644 122 81 1,000 0,14533311 0,19046504 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,1464317 0,19179551 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,1464317 0,19168634 ! positive regulation of ossification GO:0045778 30 19 0,000 0,1464317 0,19157731 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,1464317 0,1914684 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,1464317 0,19135961 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,1464317 0,19125094 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,1464317 0,1911424 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,1464317 0,19103398 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,1464317 0,19092568 ! sensory perception of taste GO:0050909 23 19 0,000 0,1464317 0,19081751 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,1464317 0,19070946 ! smooth muscle contraction GO:0006939 36 19 0,000 0,1464317 0,19060153 ! peroxisome organization GO:0007031 29 19 0,000 0,1464317 0,19049373 ! digestive system process GO:0022600 30 19 0,000 0,1464317 0,19038604 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,1464317 0,19027848 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,1464317 0,19017104 ! response to vitamin A GO:0033189 26 19 0,000 0,1464317 0,19006372 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,1464317 0,18995652 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,1464317 0,18984944 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,1464317 0,18974248 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,1464317 0,18963565 ! plasma membrane fusion GO:0045026 23 19 0,000 0,1464317 0,18952893 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,1464317 0,18942233 ! cytolysis GO:0019835 20 19 0,000 0,1464317 0,18931586 ! vasodilation GO:0042311 33 19 0,000 0,1464317 0,1892095 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,1464317 0,18910326 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,1464317 0,18899714 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,1464317 0,18889114 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,1464317 0,18878526 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,1464317 0,1886795 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,1464317 0,18857386 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,1464317 0,18846833 ! sarcomere organization GO:0045214 23 19 0,000 0,1464317 0,18836292 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,1464317 0,18825763 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,1464317 0,18815246 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,1464317 0,18804741 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,1464317 0,18794247 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,1464317 0,18783765 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,1464317 0,18773295 ! protein stabilization GO:0050821 26 19 0,000 0,1464317 0,18762836 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,15107313 0,19346782 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,15351911 0,19649079 ! iron ion transport GO:0006826 37 20 0,000 0,15351911 0,19638151 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,15351911 0,19627234 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,15351911 0,1961633 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,15351911 0,19605438 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,15351911 0,19594559 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,15351911 0,19583691 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,15351911 0,19572835 ! spinal cord development GO:0021510 31 20 0,000 0,15351911 0,19561991 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,15351911 0,1955116 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,15351911 0,1954034 ! chromosome condensation GO:0030261 31 20 0,000 0,15351911 0,19529532 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,15351911 0,19518737 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,15351911 0,19507953 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,15351911 0,19497181 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,15351911 0,19486421 ! DNA modification GO:0006304 28 20 0,000 0,15351911 0,19475673 ! collagen fibril organization GO:0030199 45 20 0,000 0,15351911 0,19464936 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,15351911 0,19454212 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,15351911 0,19443499 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,15351911 0,19432798 ! collagen catabolic process GO:0030574 25 20 0,000 0,15351911 0,19422109 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,15351911 0,19411432 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,15351911 0,19400766 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,15351911 0,19390112 ! alditol metabolic process GO:0019400 24 20 0,000 0,15351911 0,1937947 ! actin filament-based movement GO:0030048 34 20 0,000 0,15351911 0,1936884 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,15685774 0,19779211 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,16054807 0,20233455 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,16054807 0,20222374 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,16054807 0,20211306 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,16054807 0,20200249 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,16054807 0,20189205 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,16054807 0,20178173 GO:0009799|determination of symmetry, ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,16054807 0,20167152 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,16054807 0,20156144 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,16054807 0,20145148 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,16054807 0,20134163 ! phototransduction GO:0007602 25 21 0,000 0,16054807 0,20123191 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,16054807 0,20112231 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,16054807 0,20101282 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,16054807 0,20090346 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,16054807 0,20079421 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,16054807 0,20068509 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,16054807 0,20057608 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,16054807 0,20046719 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,16054807 0,20035841 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,16054807 0,20024976 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,16054807 0,20014122 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,16054807 0,20003281 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,16054807 0,1999245 ! fatty acid transport GO:0015908 30 21 0,000 0,16054807 0,19981632 ! immunoglobulin production GO:0002377 33 21 0,000 0,16054807 0,19970825 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,16054807 0,1996003 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,16054807 0,19949247 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,16054807 0,19938475 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,16054807 0,19927715 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,16054807 0,19916966 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,16054807 0,1990623 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,16054807 0,19895504 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,16054807 0,1988479 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,16054807 0,19874088 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,16054807 0,19863397 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,16054807 0,19852718 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,16054807 0,1984205 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,16268394 0,20095223 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 1,000 0,16268394 0,20084437 ! protein processing GO:0016485 114 88 1,000 0,16561171 0,20434922 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,16751906 0,20659187 ! viral genome replication GO:0019079 29 22 0,000 0,16751906 0,20648116 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,16751906 0,20637057 ! leukocyte adhesion GO:0007159 38 22 0,000 0,16751906 0,20626009 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,16751906 0,20614973 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,16751906 0,20603949 ! vasculogenesis GO:0001570 33 22 0,000 0,16751906 0,20592937 ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,16751906 0,20581936 ! lysosome organization GO:0007040 37 22 0,000 0,16751906 0,20570947 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,16751906 0,2055997 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,16751906 0,20549005 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,16751906 0,20538051 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,16751906 0,20527109 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,16751906 0,20516179 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,16751906 0,20505261 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,16751906 0,20494353 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,16751906 0,20483458 ! neuron fate commitment GO:0048663 32 23 0,000 0,17443256 0,21317476 ! embryonic pattern specification GO:0009880 31 23 0,000 0,17443256 0,21306155 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,17443256 0,21294846 ! myelination GO:0042552 35 23 0,000 0,17443256 0,21283549 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,17443256 0,21272264 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,17443256 0,21260991 ! vesicle targeting GO:0006903 32 23 0,000 0,17443256 0,2124973 ! osteoblast differentiation GO:0001649 40 23 0,000 0,17443256 0,21238481 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,17443256 0,21227243 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,17443256 0,21216018 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,17443256 0,21204804 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,17443256 0,21193603 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,17443256 0,21182413 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,17443256 0,21171235 ! cell fate determination GO:0001709 45 23 0,000 0,17443256 0,21160068 ! pentose metabolic process GO:0019321 31 23 0,000 0,17443256 0,21148914 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,17443256 0,21137771 ! spermatid development GO:0007286 33 23 0,000 0,17443256 0,2112664 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,17443256 0,21115521 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,17443256 0,21104413 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,17443256 0,21093317 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,17443256 0,21082233 ! telomere organization GO:0032200 32 23 0,000 0,17443256 0,21071161 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,17443256 0,210601 ! regulation of amine transport GO:0051952 38 23 0,000 0,17443256 0,2104905 ! liver development GO:0001889 40 23 0,000 0,17443256 0,21038012 ! response to virus GO:0009615 122 91 1,000 0,17444947 0,21029024 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,17741238 0,21374985 ! positive regulation of immune response GO:0050778 121 92 1,000 0,17741238 0,21363794 ! sulfur metabolic process GO:0006790 118 92 1,000 0,17741238 0,21352615 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,18128904 0,21807783 ! initiation of viral infection GO:0019059 42 24 0,000 0,18128904 0,21796383 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,18128904 0,21784995 ! superoxide metabolic process GO:0006801 32 24 0,000 0,18128904 0,21773619 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,18128904 0,21762255 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,18128904 0,21750903 ! fat cell differentiation GO:0045444 37 24 0,000 0,18128904 0,21739562 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,18128904 0,21728234 ! sperm motility GO:0030317 27 24 0,000 0,18128904 0,21716917 ! vacuole organization GO:0007033 39 24 0,000 0,18128904 0,21705612 ! receptor metabolic process GO:0043112 37 24 0,000 0,18128904 0,21694318 ! neural crest cell development GO:0014032 39 24 0,000 0,18128904 0,21683037 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,18128904 0,21671767 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,18128904 0,21660509 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,18128904 0,21649263 ! glutathione metabolic process GO:0006749 29 24 0,000 0,18128904 0,21638028 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,18128904 0,21626805 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,18128904 0,21615594 ! response to oxidative stress GO:0006979 141 94 1,000 0,18336164 0,21851387 ! angiogenesis GO:0001525 149 95 1,000 0,18634733 0,22195695 ! carboxylic acid transport GO:0046942 147 95 1,000 0,18634733 0,22184206 GO:0015849|organic acid transport, ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,18808897 0,2237996 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,18808897 0,22368388 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,18808897 0,22356828 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,18808897 0,2234528 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,18808897 0,22333744 ! peptide transport GO:0015833 43 25 0,000 0,18808897 0,2232222 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,18808897 0,22310708 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,18808897 0,22299208 ! phospholipid transport GO:0015914 35 25 0,000 0,18808897 0,22287719 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,18808897 0,22276242 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,18808897 0,22264778 ! detection of light stimulus GO:0009583 30 25 0,000 0,18808897 0,22253325 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,18808897 0,22241883 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,18808897 0,22230454 ! protein maturation GO:0051604 129 96 1,000 0,18933997 0,22366818 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,1948328 0,23003873 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,1948328 0,2299207 ! translational initiation GO:0006413 43 26 0,000 0,1948328 0,22980279 ! circadian rhythm GO:0007623 42 26 0,000 0,1948328 0,22968501 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,1948328 0,22956734 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,1948328 0,22944979 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,1948328 0,22933237 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,1948328 0,22921506 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,1948328 0,22909788 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,1948328 0,22898081 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,1948328 0,22886386 ! regulation of coagulation GO:0050818 39 26 0,000 0,1948328 0,22874704 ! protein import GO:0017038 156 99 1,000 0,19835642 0,23276519 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,20137371 0,23618539 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,20137371 0,23606501 ! protein localization in organelle GO:0033365 161 100 1,000 0,20137371 0,23594475 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,201521 0,2359971 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,201521 0,235877 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,201521 0,23575702 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,201521 0,23563717 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,201521 0,23551743 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,201521 0,23539782 ! acute-phase response GO:0006953 42 27 0,000 0,201521 0,23527833 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,201521 0,23515896 ! myofibril assembly GO:0030239 36 27 0,000 0,201521 0,23503971 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,201521 0,23492058 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,201521 0,23480157 ! natural killer cell activation GO:0030101 35 27 0,000 0,201521 0,23468269 ! lipid oxidation GO:0034440 38 27 0,000 0,201521 0,23456392 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,201521 0,23444528 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,201521 0,23432675 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,201521 0,23420834 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,201521 0,23409005 GO:0043433|negative regulation of transcription factor activity, ! gene silencing GO:0016458 41 27 0,000 0,201521 0,23397189 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,20815403 0,24155109 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,20815403 0,24142928 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,20815403 0,24130759 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,20815403 0,24118603 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,20815403 0,24106459 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,20815403 0,24094326 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,20815403 0,24082207 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,20815403 0,24070099 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,20815403 0,24058003 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,20815403 0,2404592 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,20815403 0,24033849 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,20815403 0,2402179 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,20815403 0,24009743 ! mesoderm formation GO:0001707 46 28 0,000 0,20815403 0,23997708 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,20815403 0,23985685 ! ensheathment of neurons GO:0007272 43 28 0,000 0,20815403 0,23973674 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,20815403 0,23961675 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,20815403 0,23949688 ! placenta development GO:0001890 37 28 0,000 0,20815403 0,23937713 ! regulation of B cell activation GO:0050864 42 28 0,000 0,20815403 0,2392575 ! regulation of innate immune response GO:0045088 38 29 0,000 0,21473233 0,24669548 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,21473233 0,24657232 ! protein targeting to membrane GO:0006612 53 29 0,000 0,21473233 0,24644928 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,21473233 0,24632636 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,21473233 0,24620357 ! muscle cell development GO:0055001 38 29 0,000 0,21473233 0,2460809 ! formation of primary germ layer GO:0001704 48 29 0,000 0,21473233 0,24595835 ! eye morphogenesis GO:0048592 51 29 0,000 0,21473233 0,24583592 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,21473233 0,24571361 ! collagen metabolic process GO:0032963 40 30 0,000 0,22125636 0,25305302 ! organic anion transport GO:0015711 51 30 0,000 0,22125636 0,25292724 ! cholesterol transport GO:0030301 46 30 0,000 0,22125636 0,2528016 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,22125636 0,25267608 ! spindle organization GO:0007051 37 30 0,000 0,22125636 0,25255068 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,22125636 0,25242541 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,22125636 0,25230026 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,22125636 0,25217523 ! ceramide metabolic process GO:0006672 43 30 0,000 0,22125636 0,25205033 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,22125636 0,25192555 ! adult locomotory behavior GO:0008344 47 30 0,000 0,22125636 0,2518009 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,22125636 0,25167637 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,22125636 0,25155196 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,22125636 0,25142768 ! negative regulation of secretion GO:0051048 49 31 0,000 0,22772655 0,25865238 ! glial cell differentiation GO:0010001 55 31 0,000 0,22772655 0,25852471 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,22772655 0,25839717 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,22772655 0,25826976 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,22772655 0,25814247 ! odontogenesis GO:0042476 50 31 0,000 0,22772655 0,2580153 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,22772655 0,25788826 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,22772655 0,25776135 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,22772655 0,25763456 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,22772655 0,2575079 ! cell fate specification GO:0001708 37 31 0,000 0,22772655 0,25738136 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,22772655 0,25725494 ! RNA modification GO:0009451 40 31 0,000 0,22772655 0,25712865 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,23414335 0,26424422 ! meiosis I GO:0007127 52 32 0,000 0,23414335 0,26411462 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,23414335 0,26398515 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,23414335 0,26385581 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,23414335 0,2637266 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,23414335 0,26359751 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,23414335 0,26346855 ! cytokine production GO:0001816 44 32 0,000 0,23414335 0,26333971 ! vesicle localization GO:0051648 47 32 0,000 0,23414335 0,263211 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,24050721 0,27023282 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,24050721 0,27010087 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,24050721 0,26996904 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,24050721 0,26983735 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,24050721 0,26970579 ! sister chromatid segregation GO:0000819 46 33 0,000 0,24050721 0,26957435 ! ear morphogenesis GO:0042471 42 33 0,000 0,24050721 0,26944305 ! actomyosin structure organization GO:0031032 43 33 0,000 0,24050721 0,26931187 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,24050721 0,26918081 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,24050721 0,26904989 ! nucleus organization GO:0006997 49 33 0,000 0,24050721 0,26891909 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,24050721 0,26878842 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,24050721 0,26865788 ! lipid homeostasis GO:0055088 55 33 0,000 0,24050721 0,26852746 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,24050721 0,26839717 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,24050721 0,26826701 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,24050721 0,26813697 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,24681854 0,27504004 ! mRNA catabolic process GO:0006402 48 34 0,000 0,24681854 0,27490685 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,24681854 0,27477378 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,24681854 0,27464085 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,24681854 0,27450805 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,24681854 0,27437537 ! neuron migration GO:0001764 46 34 0,000 0,24681854 0,27424282 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,24681854 0,2741104 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,24681854 0,27397811 ! polyol metabolic process GO:0019751 44 34 0,000 0,24681854 0,27384594 ! aerobic respiration GO:0009060 47 34 0,000 0,24681854 0,2737139 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,24681854 0,27358199 ! embryonic organ development GO:0048568 45 34 0,000 0,24681854 0,27345021 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,24681854 0,27331856 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,25307778 0,28011497 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,25307778 0,27998023 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,25307778 0,27984563 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,25307778 0,27971115 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,25307778 0,2795768 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,25307778 0,27944258 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,25307778 0,27930849 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,25307778 0,27917453 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,25307778 0,2790407 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,25307778 0,278907 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,25307778 0,27877342 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,25928537 0,28547456 ! negative regulation of binding GO:0051100 58 36 0,000 0,25928537 0,28533796 ! organic ether metabolic process GO:0018904 46 36 0,000 0,25928537 0,2852015 ! tissue remodeling GO:0048771 62 36 0,000 0,25928537 0,28506518 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,25928537 0,28492898 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,25928537 0,28479291 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,25928537 0,28465697 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,26544171 0,29127669 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,26544171 0,29113779 ! ion transmembrane transport GO:0034220 56 37 0,000 0,26544171 0,29099902 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,26544171 0,29086038 ! regulation of protein secretion GO:0050708 51 37 0,000 0,26544171 0,29072188 ! amino acid activation GO:0043038 52 37 0,000 0,26544171 0,2905835 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,26544171 0,29044526 ! gliogenesis GO:0042063 71 38 0,000 0,27154724 0,29698462 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,27154724 0,29684347 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,27154724 0,29670245 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,27154724 0,29656157 ! phagocytosis GO:0006909 60 38 0,000 0,27154724 0,29642082 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,27760237 0,30288684 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,27760237 0,30274322 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,27760237 0,30259974 ! chromatin remodeling GO:0006338 68 39 0,000 0,27760237 0,3024564 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,27760237 0,30231319 ! synapse organization GO:0050808 55 39 0,000 0,27760237 0,30217012 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,28360751 0,30856068 ! response to calcium ion GO:0051592 58 40 0,000 0,28360751 0,30841479 ! regulation of tube size GO:0035150 60 40 0,000 0,28360751 0,30826903 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,28360751 0,30812342 ! peptide metabolic process GO:0006518 56 40 0,000 0,28360751 0,30797794 ! inner ear development GO:0048839 57 40 0,000 0,28360751 0,3078326 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,28360751 0,30768739 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,28360751 0,30754233 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,28360751 0,3073974 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,28956307 0,3137047 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,28956307 0,313557 ! endosome transport GO:0016197 71 41 0,000 0,28956307 0,31340944 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,28956307 0,31326203 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,28956307 0,31311475 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,29546946 0,31935139 ! cellular component disassembly GO:0022411 64 42 0,000 0,29546946 0,31920139 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,29546946 0,31905153 ! excretion GO:0007588 63 42 0,000 0,29546946 0,31890181 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,29546946 0,31875224 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,29546946 0,3186028 ! tRNA processing GO:0008033 49 43 0,000 0,30132709 0,32476677 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,30132709 0,32461466 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,30713634 0,33071797 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,30713634 0,33056321 ! regulation of ion transport GO:0043269 57 44 0,000 0,30713634 0,3304086 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,30713634 0,33025413 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,30713634 0,3300998 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,30713634 0,32994562 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,30713634 0,32979159 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,30713634 0,32963769 ! RNA catabolic process GO:0006401 64 45 0,000 0,31289762 0,33566443 ! regulation of translational initiation GO:0006446 64 45 0,000 0,31289762 0,33550794 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,31289762 0,3353516 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,31289762 0,3351954 ! cell recognition GO:0008037 58 45 0,000 0,31289762 0,33503935 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,31861132 0,34099863 ! cell redox homeostasis GO:0045454 63 46 0,000 0,31861132 0,34084002 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,31861132 0,34068156 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,32427784 0,34657948 ! viral infectious cycle GO:0019058 71 47 0,000 0,32427784 0,3464185 ! endocrine system development GO:0035270 83 47 0,000 0,32427784 0,34625767 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,32427784 0,346097 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,32427784 0,34593647 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,32427784 0,34577609 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,32427784 0,34561586 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,32427784 0,34545578 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein polymerization GO:0032271 71 47 0,000 0,32427784 0,34529585 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,32989755 0,35111725 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,32989755 0,35095484 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,32989755 0,35079259 ! regulation of endocytosis GO:0030100 63 48 0,000 0,32989755 0,35063049 ! nuclear export GO:0051168 69 48 0,000 0,32989755 0,35046853 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,32989755 0,35030673 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,32989755 0,35014507 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,33547085 0,3558962 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,33547085 0,35573211 ! sensory perception of smell GO:0007608 61 49 0,000 0,33547085 0,35556818 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,33547085 0,3554044 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,33547085 0,35524077 ! RNA elongation GO:0006354 62 49 0,000 0,33547085 0,35507729 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,33547085 0,35491396 ! regulation of actin filament length GO:0030832 72 50 0,000 0,34099811 0,3605957 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,34099811 0,36042999 ! membrane fusion GO:0006944 80 50 0,000 0,34099811 0,36026443 ! proton transport GO:0015992 75 50 0,000 0,34099811 0,36009901 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,34099811 0,35993376 ! positive regulation of secretion GO:0051047 71 51 0,000 0,34647971 0,36555199 ! hydrogen transport GO:0006818 77 51 0,000 0,34647971 0,36538438 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,34647971 0,36521693 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,34647971 0,36504963 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,34647971 0,36488248 ! adult behavior GO:0030534 80 51 0,000 0,34647971 0,36471549 ! transition metal ion transport GO:0000041 74 52 0,000 0,35191603 0,37026847 ! regulation of cellular component size GO:0032535 74 52 0,000 0,35191603 0,37009916 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,35191603 0,36993001 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,35191603 0,36976102 ! establishment of organelle localization GO:0051656 85 52 0,000 0,35191603 0,36959218 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,35730743 0,37508311 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,35730743 0,374912 ! single fertilization GO:0007338 59 53 0,000 0,35730743 0,37474104 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,36265429 0,38017542 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,36265429 0,38000222 ! DNA catabolic process GO:0006308 67 54 0,000 0,36265429 0,37982918 ! detection of external stimulus GO:0009581 66 54 0,000 0,36265429 0,37965629 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,36265429 0,37948356 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,36265429 0,37931099 ! mesoderm development GO:0007498 76 55 0,000 0,36795697 0,38468229 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,36795697 0,38450751 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,36795697 0,3843329 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,37321584 0,38964886 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,37843125 0,39491464 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,37843125 0,39473554 ! camera-type eye development GO:0043010 88 57 0,000 0,37843125 0,3945566 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,38873312 0,40511381 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,39382028 0,41022946 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,39382028 0,41004375 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,39382028 0,40985821 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,39382028 0,40967284 ! fertilization GO:0009566 68 60 0,000 0,39382028 0,40948764 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,3988654 0,41454606 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,3988654 0,41435882 ! extracellular matrix organization GO:0030198 103 61 0,000 0,3988654 0,41417175 ! amine catabolic process GO:0009310 90 62 0,000 0,40386882 0,41917793 ! neurotransmitter transport GO:0006836 81 62 0,000 0,40386882 0,41898885 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,40386882 0,41879995 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,40386882 0,41861121 ! organelle localization GO:0051640 96 62 0,000 0,40386882 0,41842265 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,40883087 0,42337281 ! regulation of lipase activity GO:0060191 109 63 0,000 0,40883087 0,42318227 ! appendage morphogenesis GO:0035107 93 64 0,000 0,41375191 0,4280834 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,41375191 0,42789091 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,41375191 0,4276986 ! adaptive immune response GO:0002250 94 64 0,000 0,41375191 0,42750647 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,41863226 0,43235483 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,41863226 0,43216077 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,41863226 0,43196689 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,42347227 0,43676512 ! antigen processing and presentation GO:0019882 96 66 0,000 0,42347227 0,43656935 ! axon guidance GO:0007411 99 66 0,000 0,42347227 0,43637375 ! regulation of immune effector process GO:0002697 101 66 0,000 0,42347227 0,43617833 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,42827225 0,44092488 ! acute inflammatory response GO:0002526 92 68 0,000 0,43303254 0,44562633 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,43303254 0,44542703 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,43303254 0,44522792 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,43303254 0,44502898 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,43775347 0,44967976 ! eye development GO:0001654 111 70 0,000 0,44243536 0,45428631 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,44243536 0,45408359 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,44707853 0,45864435 ! muscle cell differentiation GO:0042692 104 71 0,000 0,44707853 0,45843987 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,44707853 0,45823557 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,44707853 0,45803146 ! regulation of blood pressure GO:0008217 107 73 0,000 0,45624998 0,46721948 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,45624998 0,46701155 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,46077889 0,47143748 ! digestion GO:0007586 97 74 0,000 0,46077889 0,47122786 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,46077889 0,47101842 ! blood coagulation GO:0007596 116 75 0,000 0,46527033 0,47539839 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,46527033 0,47518729 ! amine biosynthetic process GO:0009309 97 76 0,000 0,46972462 0,47952358 ! tRNA metabolic process GO:0006399 95 76 0,000 0,46972462 0,47931084 ! response to unfolded protein GO:0006986 99 76 0,000 0,46972462 0,47909828 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,47414206 0,48338951 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,47414206 0,48317534 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,47852295 0,48742373 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,47852295 0,48720796 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,48286759 0,49141392 ! cellular respiration GO:0045333 107 79 0,000 0,48286759 0,49119658 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,48286759 0,49097943 ! regulation of lyase activity GO:0051339 133 79 0,000 0,48286759 0,49076247 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,48286759 0,4905457 ! chromatin assembly GO:0031497 102 80 0,000 0,48717629 0,4947044 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,48717629 0,49448608 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,49144933 0,4986032 ! hemostasis GO:0007599 125 81 0,000 0,49144933 0,49838336 ! mRNA transport GO:0051028 121 81 0,000 0,49144933 0,49816371 ! vitamin metabolic process GO:0006766 103 81 0,000 0,49144933 0,49794425 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,49144933 0,49772499 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,49568701 0,50179583 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,49568701 0,50157506 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,49988962 0,50560515 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,50405744 0,50959653 ! sterol metabolic process GO:0016125 120 84 0,000 0,50405744 0,50937263 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,50819077 0,51332401 ! transcription initiation GO:0006352 118 85 0,000 0,50819077 0,51309867 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,51228989 0,51701042 ! nucleosome organization GO:0034728 114 87 0,000 0,51635507 0,5208845 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,51635507 0,52065615 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,51635507 0,52042799 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,52038661 0,52426158 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,52038661 0,52403205 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,52038661 0,52380271 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,52438476 0,52759622 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,52438476 0,52736553 ! regulation of T cell activation GO:0050863 128 89 0,000 0,52438476 0,52713503 ! hormone metabolic process GO:0042445 121 90 0,000 0,52834982 0,53088885 ! RNA localization GO:0006403 135 91 0,000 0,53228205 0,53460642 ! ATP metabolic process GO:0046034 137 91 0,000 0,53228205 0,53437307 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,53618171 0,5380532 ! electron transport chain GO:0022900 123 94 0,000 0,54388444 0,54554479 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,55146011 0,55290246 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,55146011 0,55266154 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,55520095 0,5561682 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! extracellular structure organization GO:0043062 156 99 0,000 0,56258993 0,5633247 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,56623858 0,56673139 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,56623858 0,56648488 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,56623858 0,56623858