pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6448-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 87 43 8,000 3,724E-12 8,565E-09 ! interphase of mitotic cell cycle GO:0051329 156 86 9,000 1,052E-10 1,209E-07 ! interphase GO:0051325 159 88 9,000 1,327E-10 1,018E-07 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 6,000 2,293E-08 1,318E-05 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 3,000 4,407E-08 2,027E-05 ! induction of positive chemotaxis GO:0050930 14 8 3,000 8,772E-08 3,363E-05 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 2,299E-07 7,554E-05 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 3,595E-07 1,034E-04 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of positive chemotaxis GO:0050926 17 11 3,000 4,078E-07 1,042E-04 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of cell migration GO:0030335 92 51 5,000 6,218E-07 1,43E-04 ! positive regulation of cell motion GO:0051272 99 56 5,000 1,094E-06 2,287E-04 ! negative regulation of protein kinase activity GO:0006469 99 57 5,000 1,217E-06 2,332E-04 ! negative regulation of kinase activity GO:0033673 100 58 5,000 1,35E-06 2,389E-04 ! negative regulation of transferase activity GO:0051348 105 61 5,000 1,825E-06 2,999E-04 ! male sex differentiation GO:0046661 53 39 4,000 3,642E-06 5,584E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 3,66E-06 5,261E-04 ! positive regulation of phosphorylation GO:0042327 102 70 5,000 4,124E-06 5,58E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 4,277E-06 5,464E-04 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 5,000 4,867E-06 5,891E-04 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of locomotion GO:0040017 35 20 3,000 5,741E-06 6,602E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! negative regulation of growth GO:0045926 123 75 5,000 6,181E-06 6,769E-04 ! regulation of chemotaxis GO:0050920 36 21 3,000 7,058E-06 7,379E-04 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 7,451E-06 7,451E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 7,451E-06 7,14E-04 ! positive regulation of cell cycle GO:0045787 77 45 4,000 7,508E-06 6,907E-04 ! response to UV GO:0009411 75 46 4,000 8,383E-06 7,416E-04 ! regulation of behavior GO:0050795 38 22 3,000 8,587E-06 7,315E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 1,187E-05 9,749E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 1,187E-05 9,413E-04 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 1,187E-05 9,099E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,187E-05 8,806E-04 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 1,187E-05 8,531E-04 ! reproductive developmental process GO:0003006 127 89 5,000 1,666E-05 1,161E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 1,772E-05 1,199E-03 ! regulation of hormone metabolic process GO:0032350 15 9 2,000 1,772E-05 1,165E-03 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 2,142E-05 1,369E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 2,521E-05 1,567E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 2,000 2,521E-05 1,526E-03 ! lung development GO:0030324 94 59 4,000 2,876E-05 1,696E-03 ! urogenital system development GO:0001655 101 61 4,000 3,385E-05 1,947E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 3,451E-05 1,936E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 3,451E-05 1,89E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 3,451E-05 1,846E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 3,451E-05 1,804E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 3,451E-05 1,764E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of cell growth GO:0030308 106 62 4,000 3,665E-05 1,832E-03 ! respiratory tube development GO:0030323 99 62 4,000 3,665E-05 1,793E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 4,277E-05 2,049E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 4,000 4,277E-05 2,007E-03 ! respiratory system development GO:0060541 100 64 4,000 4,277E-05 1,967E-03 ! carbohydrate homeostasis GO:0033500 39 33 3,000 4,563E-05 2,058E-03 GO:0042593|glucose homeostasis, ! reproductive structure development GO:0048608 90 65 4,000 4,611E-05 2,039E-03 ! development of primary male sexual characteristics GO:0046546 44 34 3,000 5,148E-05 2,234E-03 ! development of primary sexual characteristics GO:0045137 92 68 4,000 5,736E-05 2,443E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 5,929E-05 2,479E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 5,929E-05 2,435E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 7,513E-05 3,031E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 7,513E-05 2,979E-03 ! response to hypoxia GO:0001666 132 72 4,000 7,552E-05 2,944E-03 ! pigmentation GO:0043473 74 38 3,000 8,042E-05 3,083E-03 ! response to oxygen levels GO:0070482 137 74 4,000 8,612E-05 3,247E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 9,35E-05 3,468E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 9,35E-05 3,413E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 9,35E-05 3,36E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 9,35E-05 3,308E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 9,865E-05 3,438E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 9,865E-05 3,386E-03 ! sex differentiation GO:0007548 105 77 4,000 1,041E-04 3,522E-03 ! epithelial cell differentiation GO:0030855 55 41 3,000 1,088E-04 3,627E-03 ! positive regulation of protein modification process GO:0031401 107 78 4,000 1,107E-04 3,638E-03 ! G1 phase GO:0051318 27 16 2,000 1,146E-04 3,711E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,146E-04 3,66E-03 ! regulation of cell cycle process GO:0010564 122 81 4,000 1,325E-04 4,173E-03 ! regulation of viral genome replication GO:0045069 24 17 2,000 1,385E-04 4,305E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 1,385E-04 4,247E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1,385E-04 4,191E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 1,385E-04 4,137E-03 ! negative regulation of cell migration GO:0030336 92 44 3,000 1,438E-04 4,241E-03 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 1,438E-04 4,187E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 1,571E-04 4,517E-03 ! pigmentation during development GO:0048066 31 18 2,000 1,655E-04 4,698E-03 ! regulation of glucose import GO:0046324 21 18 2,000 1,655E-04 4,641E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 1,655E-04 4,585E-03 ! cell cycle arrest GO:0007050 150 86 4,000 1,758E-04 4,813E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 1,864E-04 5,043E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 1,956E-04 5,232E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,956E-04 5,172E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 1,956E-04 5,113E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 1,956E-04 5,056E-03 ! sex determination GO:0007530 29 19 2,000 1,956E-04 4,999E-03 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 1,956E-04 4,944E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 2,024E-04 5,059E-03 ! regulation of angiogenesis GO:0045765 94 49 3,000 2,193E-04 5,424E-03 ! cartilage development GO:0051216 70 49 3,000 2,193E-04 5,366E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 2,291E-04 5,548E-03 ! negative regulation of cell motion GO:0051271 104 51 3,000 2,563E-04 6,14E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 2,662E-04 6,311E-03 ! gluconeogenesis GO:0006094 25 21 2,000 2,662E-04 6,246E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 2,662E-04 6,183E-03 ! regulation of binding GO:0051098 151 95 4,000 2,801E-04 6,443E-03 ! response to light stimulus GO:0009416 153 96 4,000 2,941E-04 6,697E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 3,068E-04 6,918E-03 ! vasculogenesis GO:0001570 33 22 2,000 3,068E-04 6,851E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 3,068E-04 6,785E-03 GO:0010810|regulation of cell-substrate adhesion, ! regulation of mitosis GO:0007088 84 54 3,000 3,198E-04 7,006E-03 GO:0051783|regulation of nuclear division, ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 3,392E-04 7,361E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 3,513E-04 7,551E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 3,513E-04 7,481E-03 ! regulation of viral reproduction GO:0050792 32 23 2,000 3,513E-04 7,413E-03 ! cellular response to oxidative stress GO:0034599 33 23 2,000 3,513E-04 7,345E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,599E-04 7,457E-03 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 3,599E-04 7,39E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 3,599E-04 7,325E-03 ! embryonic hemopoiesis GO:0035162 10 5 1,000 3,599E-04 7,261E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 3,599E-04 7,198E-03 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 3,599E-04 7,136E-03 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 3,599E-04 7,075E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 3,599E-04 7,015E-03 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 3,599E-04 6,956E-03 ! microvillus organization GO:0032528 7 5 1,000 3,599E-04 6,898E-03 GO:0030033|microvillus assembly, ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 3,599E-04 6,841E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 3,599E-04 6,785E-03 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 3,599E-04 6,73E-03 GO:0045686|negative regulation of glial cell differentiation, ! cranial nerve morphogenesis GO:0021602 6 5 1,000 3,599E-04 6,675E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 3,599E-04 6,622E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 3,599E-04 6,569E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 3,599E-04 6,518E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 3,599E-04 6,467E-03 ! gonad development GO:0008406 79 57 3,000 3,94E-04 7,024E-03 ! pyruvate metabolic process GO:0006090 29 24 2,000 3,997E-04 7,072E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 3,997E-04 7,018E-03 ! fat cell differentiation GO:0045444 37 24 2,000 3,997E-04 6,965E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 3,997E-04 6,912E-03 ! male gonad development GO:0008584 33 25 2,000 4,522E-04 7,762E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 4,522E-04 7,704E-03 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 4,522E-04 7,648E-03 ! regulation of homeostatic process GO:0032844 105 60 3,000 4,796E-04 8,052E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 5,09E-04 8,483E-03 ! prostate gland development GO:0030850 9 6 1,000 5,377E-04 8,897E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 5,377E-04 8,833E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 5,377E-04 8,771E-03 ! mRNA stabilization GO:0048255 15 6 1,000 5,377E-04 8,709E-03 GO:0043489|RNA stabilization, ! pigment granule organization GO:0048753 11 6 1,000 5,377E-04 8,648E-03 ! histidine metabolic process GO:0006547 6 6 1,000 5,377E-04 8,588E-03 GO:0009075|histidine family amino acid metabolic process, ! ER overload response GO:0006983 7 6 1,000 5,377E-04 8,529E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 5,377E-04 8,47E-03 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 5,377E-04 8,413E-03 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 5,377E-04 8,356E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 5,377E-04 8,3E-03 ! DNA topological change GO:0006265 8 6 1,000 5,377E-04 8,245E-03 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 5,377E-04 8,19E-03 ! gas homeostasis GO:0033483 11 6 1,000 5,377E-04 8,136E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 5,377E-04 8,083E-03 ! regulation of epidermal cell differentiation GO:0045604 7 6 1,000 5,377E-04 8,03E-03 ! negative regulation of B cell activation GO:0050869 9 6 1,000 5,377E-04 7,979E-03 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 5,701E-04 8,405E-03 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 5,701E-04 8,351E-03 GO:0043433|negative regulation of transcription factor activity, ! regulation of transcription factor activity GO:0051090 97 63 3,000 5,778E-04 8,411E-03 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 5,778E-04 8,358E-03 ! cell cycle checkpoint GO:0000075 108 64 3,000 6,135E-04 8,819E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 6,357E-04 9,081E-03 ! regulation of B cell activation GO:0050864 42 28 2,000 6,357E-04 9,025E-03 ! hexose biosynthetic process GO:0019319 35 29 2,000 7,059E-04 9,961E-03 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 7,498E-04 0,01051523 ! microtubule bundle formation GO:0001578 8 7 1,000 7,498E-04 0,0104515 ! T-helper 1 type immune response GO:0042088 11 7 1,000 7,498E-04 0,01038854 ! hemoglobin metabolic process GO:0020027 10 7 1,000 7,498E-04 0,01032633 ! regulation of pigmentation during development GO:0048070 15 7 1,000 7,498E-04 0,01026487 ! organ growth GO:0035265 11 7 1,000 7,498E-04 0,01020413 ! behavioral fear response GO:0001662 13 7 1,000 7,498E-04 0,0101441 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 7,498E-04 0,01008478 ! B cell lineage commitment GO:0002326 17 7 1,000 7,498E-04 0,01002615 ! mast cell activation GO:0045576 9 7 1,000 7,498E-04 9,968E-03 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 7,498E-04 9,911E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 7,498E-04 9,854E-03 ! neuroblast proliferation GO:0007405 13 7 1,000 7,498E-04 9,798E-03 ! peptidyl-threonine modification GO:0018210 18 7 1,000 7,498E-04 9,743E-03 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 7,498E-04 9,688E-03 ! hindbrain development GO:0030902 45 30 2,000 7,809E-04 0,01003375 ! negative regulation of cell activation GO:0050866 44 30 2,000 7,809E-04 9,978E-03 ! metanephros development GO:0001656 58 31 2,000 8,608E-04 0,01093782 ! positive regulation of gene-specific transcription GO:0043193 47 31 2,000 8,608E-04 0,01087772 ! leukocyte chemotaxis GO:0030595 43 31 2,000 8,608E-04 0,01081828 GO:0060326|cell chemotaxis, ! response to metal ion GO:0010038 103 70 3,000 8,61E-04 0,01076251 ! regulation of protein stability GO:0031647 48 32 2,000 9,456E-04 0,01175655 ! monosaccharide biosynthetic process GO:0046364 38 32 2,000 9,456E-04 0,01169334 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 9,958E-04 0,01224722 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 9,958E-04 0,01218208 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 9,958E-04 0,01211762 ! melanin metabolic process GO:0006582 12 8 1,000 9,958E-04 0,01205385 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 9,958E-04 0,01199074 ! regulation of vascular permeability GO:0043114 12 8 1,000 9,958E-04 0,01192829 ! regulation of gliogenesis GO:0014013 20 8 1,000 9,958E-04 0,01186648 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 9,958E-04 0,01180531 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 9,958E-04 0,01174477 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 9,958E-04 0,01168485 ! mitochondrion organization GO:0007005 104 73 3,000 1,008E-03 0,01176827 ! nucleus organization GO:0006997 49 33 2,000 1,036E-03 0,01203011 ! negative regulation of DNA binding GO:0043392 54 33 2,000 1,036E-03 0,01196966 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,036E-03 0,01190981 ! response to inorganic substance GO:0010035 115 75 3,000 1,115E-03 0,01276142 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 1,131E-03 0,01287632 ! regulation of DNA binding GO:0051101 119 77 3,000 1,23E-03 0,01393891 ! gland development GO:0048732 148 77 3,000 1,23E-03 0,01387058 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,275E-03 0,014307 ! regulation of glycolysis GO:0006110 15 9 1,000 1,275E-03 0,01423755 ! lung alveolus development GO:0048286 17 9 1,000 1,275E-03 0,01416877 ! T cell selection GO:0045058 18 9 1,000 1,275E-03 0,01410065 ! epithelial cell development GO:0002064 10 9 1,000 1,275E-03 0,01403318 ! motor axon guidance GO:0008045 14 9 1,000 1,275E-03 0,01396636 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,275E-03 0,01390017 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,275E-03 0,0138346 ! DNA ligation GO:0006266 14 9 1,000 1,275E-03 0,01376965 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 1,275E-03 0,0137053 ! methionine biosynthetic process GO:0009086 10 9 1,000 1,275E-03 0,01364156 ! oocyte differentiation GO:0009994 12 9 1,000 1,275E-03 0,0135784 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,275E-03 0,01351583 ! spleen development GO:0048536 15 9 1,000 1,275E-03 0,01345383 ! embryonic placenta development GO:0001892 12 9 1,000 1,275E-03 0,0133924 ! response to nicotine GO:0035094 16 9 1,000 1,275E-03 0,01333152 ! localization within membrane GO:0051668 15 9 1,000 1,275E-03 0,0132712 ! response to reactive oxygen species GO:0000302 55 36 2,000 1,338E-03 0,01385736 ! negative regulation of binding GO:0051100 58 36 2,000 1,338E-03 0,01379522 ! tissue remodeling GO:0048771 62 36 2,000 1,338E-03 0,01373363 ! alcohol biosynthetic process GO:0046165 45 38 2,000 1,566E-03 0,01601309 ! regulation of T cell proliferation GO:0042129 58 38 2,000 1,566E-03 0,01594223 ! mesenchymal cell development GO:0014031 64 38 2,000 1,566E-03 0,015872 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! folic acid and derivative biosynthetic process GO:0009396 10 10 1,000 1,588E-03 0,01601611 ! hair follicle morphogenesis GO:0031069 17 10 1,000 1,588E-03 0,01594617 ! hippocampus development GO:0021766 19 10 1,000 1,588E-03 0,01587684 ! blood vessel remodeling GO:0001974 21 10 1,000 1,588E-03 0,01580811 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 1,588E-03 0,01573997 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,588E-03 0,01567242 ! melanocyte differentiation GO:0030318 15 10 1,000 1,588E-03 0,01560544 GO:0050931|pigment cell differentiation, ! B cell proliferation GO:0042100 14 10 1,000 1,588E-03 0,01553904 ! fear response GO:0042596 16 10 1,000 1,588E-03 0,01547319 ! negative regulation of ossification GO:0030279 19 10 1,000 1,588E-03 0,01540791 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 1,588E-03 0,01534317 ! regulation of bone resorption GO:0045124 24 10 1,000 1,588E-03 0,01527897 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,588E-03 0,01521531 ! response to dsRNA GO:0043331 18 10 1,000 1,588E-03 0,01515217 ! cranial nerve development GO:0021545 12 10 1,000 1,588E-03 0,01508956 ! DNA methylation GO:0006306 15 10 1,000 1,588E-03 0,01502746 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 1,000 1,588E-03 0,01496588 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,588E-03 0,01490479 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 1,588E-03 0,0148442 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,588E-03 0,0147841 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of cell adhesion GO:0030155 159 83 3,000 1,625E-03 0,01506931 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,69E-03 0,01560681 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 1,774E-03 0,01631979 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 1,774E-03 0,01625477 ! T cell differentiation GO:0030217 65 40 2,000 1,819E-03 0,01659836 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 1,819E-03 0,01653276 ! skeletal muscle tissue development GO:0007519 123 87 3,000 1,932E-03 0,01749582 GO:0060538|skeletal muscle organ development, ! RNA polyadenylation GO:0043631 19 11 1,000 1,933E-03 0,01743341 ! focal adhesion formation GO:0048041 24 11 1,000 1,933E-03 0,01736531 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 1,933E-03 0,01729774 ! T cell homeostasis GO:0043029 20 11 1,000 1,933E-03 0,01723069 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,933E-03 0,01716417 ! male genitalia development GO:0030539 13 11 1,000 1,933E-03 0,01709815 ! digestive tract morphogenesis GO:0048546 15 11 1,000 1,933E-03 0,01703264 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! mRNA 3'-end processing GO:0031124 19 11 1,000 1,933E-03 0,01696763 ! regulation of T cell differentiation GO:0045580 59 41 2,000 1,954E-03 0,01708461 ! anatomical structure homeostasis GO:0060249 136 88 3,000 2,015E-03 0,01755343 ! cellular component disassembly GO:0022411 64 42 2,000 2,095E-03 0,01818003 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 2,095E-03 0,01811169 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 2,242E-03 0,01931227 ! leukocyte migration GO:0050900 60 43 2,000 2,242E-03 0,01924021 ! activation of caspase activity GO:0006919 65 43 2,000 2,242E-03 0,01916869 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 2,31E-03 0,01967982 ! heart looping GO:0001947 15 12 1,000 2,31E-03 0,0196072 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 2,31E-03 0,01953511 ! methionine metabolic process GO:0006555 13 12 1,000 2,31E-03 0,01946355 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 2,31E-03 0,01939252 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 2,31E-03 0,019322 ! autonomic nervous system development GO:0048483 23 12 1,000 2,31E-03 0,01925199 ! gland morphogenesis GO:0022612 23 12 1,000 2,31E-03 0,01918249 ! peptidyl-lysine modification GO:0018205 18 12 1,000 2,31E-03 0,01911349 ! response to gamma radiation GO:0010332 20 12 1,000 2,31E-03 0,01904498 ! regulation of epidermis development GO:0045682 17 12 1,000 2,31E-03 0,01897696 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,31E-03 0,01890943 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,31E-03 0,01884238 ! RNA 3'-end processing GO:0031123 20 12 1,000 2,31E-03 0,0187758 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 2,395E-03 0,01939954 ! regulation of inflammatory response GO:0050727 60 44 2,000 2,395E-03 0,01933147 ! positive regulation of defense response GO:0031349 59 45 2,000 2,555E-03 0,02054961 ! response to oxidative stress GO:0006979 141 94 3,000 2,563E-03 0,02053893 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,72E-03 0,02171825 ! regulation of chemokine production GO:0032642 17 13 1,000 2,72E-03 0,0216431 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 2,72E-03 0,02156847 ! genitalia development GO:0048806 15 13 1,000 2,72E-03 0,02149435 ! cellular pigmentation GO:0033059 24 13 1,000 2,72E-03 0,02142074 ! regulation of RNA stability GO:0043487 28 13 1,000 2,72E-03 0,02134763 ! lymphocyte homeostasis GO:0002260 24 13 1,000 2,72E-03 0,02127502 ! regulation of response to external stimulus GO:0032101 139 96 3,000 2,766E-03 0,02156737 ! response to estrogen stimulus GO:0043627 74 47 2,000 2,894E-03 0,02249093 ! negative regulation of immune system process GO:0002683 73 47 2,000 2,894E-03 0,0224152 ! positive regulation of caspase activity GO:0043280 72 48 2,000 3,074E-03 0,02372519 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 3,074E-03 0,02364584 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 3,074E-03 0,02356702 ! extracellular structure organization GO:0043062 156 99 3,000 3,092E-03 0,02362353 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 3,16E-03 0,02406799 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 3,16E-03 0,02398856 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 3,16E-03 0,02390965 ! limbic system development GO:0021761 25 14 1,000 3,16E-03 0,02383126 ! epidermis morphogenesis GO:0048730 29 14 1,000 3,16E-03 0,02375338 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 3,16E-03 0,023676 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 3,16E-03 0,02359913 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 3,16E-03 0,02352276 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 3,16E-03 0,02344688 ! muscle maintenance GO:0046716 19 14 1,000 3,16E-03 0,02337149 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 3,16E-03 0,02329658 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 3,26E-03 0,02395624 ! germ cell development GO:0007281 68 49 2,000 3,26E-03 0,02387994 ! skeletal muscle fiber development GO:0048741 73 50 2,000 3,453E-03 0,02521296 ! metencephalon development GO:0022037 19 15 1,000 3,632E-03 0,02643572 ! sulfur amino acid biosynthetic process GO:0000097 17 15 1,000 3,632E-03 0,02635232 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 3,632E-03 0,02626945 ! lipid phosphorylation GO:0046834 23 15 1,000 3,632E-03 0,0261871 ! myoblast differentiation GO:0045445 27 15 1,000 3,632E-03 0,02610527 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 3,632E-03 0,02602395 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 3,632E-03 0,02594313 ! folic acid and derivative metabolic process GO:0006760 17 15 1,000 3,632E-03 0,02586281 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 1,000 3,632E-03 0,02578298 ! defense response to virus GO:0051607 27 15 1,000 3,632E-03 0,02570365 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 3,632E-03 0,02562481 ! muscle fiber development GO:0048747 74 51 2,000 3,653E-03 0,02569303 ! aging GO:0007568 79 52 2,000 3,86E-03 0,0270643 ! regulation of bone remodeling GO:0046850 90 53 2,000 4,073E-03 0,02847616 ! kidney development GO:0001822 90 53 2,000 4,073E-03 0,02838986 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 4,135E-03 0,02872939 ! protein amino acid acetylation GO:0006473 28 16 1,000 4,135E-03 0,02864285 ! cellular response to unfolded protein GO:0034620 19 16 1,000 4,135E-03 0,02855684 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 1,000 4,135E-03 0,02847134 ! oogenesis GO:0048477 23 16 1,000 4,135E-03 0,02838635 ! neural crest cell migration GO:0001755 24 16 1,000 4,135E-03 0,02830187 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 4,135E-03 0,02821789 ! nerve development GO:0021675 18 16 1,000 4,135E-03 0,0281344 ! negative regulation of translation GO:0017148 22 16 1,000 4,135E-03 0,02805141 ! regulation of tissue remodeling GO:0034103 91 54 2,000 4,294E-03 0,02904847 ! mesoderm development GO:0007498 76 55 2,000 4,522E-03 0,03050064 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 4,667E-03 0,03138853 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 4,667E-03 0,03129702 ! cell-substrate junction assembly GO:0007044 39 17 1,000 4,667E-03 0,03120604 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 4,667E-03 0,03111559 ! neuromuscular junction development GO:0007528 23 17 1,000 4,667E-03 0,03102566 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 4,757E-03 0,03153177 ! chromosome segregation GO:0007059 83 57 2,000 5E-03 0,03304323 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 5E-03 0,03294855 ! positive regulation of DNA replication GO:0045740 29 18 1,000 5,23E-03 0,03436904 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 5,23E-03 0,03427113 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 5,23E-03 0,03417377 ! pancreas development GO:0031016 26 18 1,000 5,23E-03 0,03407696 ! response to retinoic acid GO:0032526 25 18 1,000 5,23E-03 0,03398069 ! somitogenesis GO:0001756 24 18 1,000 5,23E-03 0,03388497 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 5,23E-03 0,03378979 ! gut development GO:0048565 26 18 1,000 5,23E-03 0,03369514 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 5,23E-03 0,03360102 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 5,249E-03 0,03363071 ! regulation of heart contraction GO:0008016 91 60 2,000 5,771E-03 0,0368703 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 5,822E-03 0,03709536 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 5,822E-03 0,03699289 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 5,822E-03 0,03689098 ! response to alkaloid GO:0043279 32 19 1,000 5,822E-03 0,03678963 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 5,822E-03 0,03668884 ! response to vitamin A GO:0033189 26 19 1,000 5,822E-03 0,0365886 ! vesicle docking during exocytosis GO:0006904 24 19 1,000 5,822E-03 0,0364889 ! plasma membrane fusion GO:0045026 23 19 1,000 5,822E-03 0,03638975 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 5,822E-03 0,03629113 ! renal system process GO:0003014 35 19 1,000 5,822E-03 0,03619304 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 5,822E-03 0,03609549 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 5,822E-03 0,03599846 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 5,822E-03 0,03590195 ! homeostasis of number of cells GO:0048872 84 61 2,000 6,043E-03 0,03716331 ! extracellular matrix organization GO:0030198 103 61 2,000 6,043E-03 0,0370642 ! response to vitamin GO:0033273 29 20 1,000 6,444E-03 0,03941703 ! response to ethanol GO:0045471 37 20 1,000 6,444E-03 0,03931248 ! multicellular organismal response to stress GO:0033555 32 20 1,000 6,444E-03 0,03920848 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 6,444E-03 0,03910503 ! chromosome condensation GO:0030261 31 20 1,000 6,444E-03 0,03900212 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 6,444E-03 0,03889975 ! pallium development GO:0021543 38 20 1,000 6,444E-03 0,03879792 ! DNA modification GO:0006304 28 20 1,000 6,444E-03 0,03869662 ! positive regulation of B cell activation GO:0050871 31 20 1,000 6,444E-03 0,03859585 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 6,61E-03 0,03948804 ! sulfur amino acid metabolic process GO:0000096 24 21 1,000 7,094E-03 0,0422706 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 7,094E-03 0,04216138 ! protein amino acid acylation GO:0043543 37 21 1,000 7,094E-03 0,04205271 ! vesicle docking GO:0048278 27 21 1,000 7,094E-03 0,04194461 ! dendrite development GO:0016358 35 21 1,000 7,094E-03 0,04183706 ! ovarian follicle development GO:0001541 30 21 1,000 7,094E-03 0,04173006 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 7,094E-03 0,0416236 ! cell aging GO:0007569 32 21 1,000 7,094E-03 0,04151769 ! regulation of insulin secretion GO:0050796 26 21 1,000 7,094E-03 0,04141232 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 7,094E-03 0,04130748 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 7,094E-03 0,04120316 ! response to cytokine stimulus GO:0034097 47 21 1,000 7,094E-03 0,04109938 ! regulation of caspase activity GO:0043281 97 65 2,000 7,207E-03 0,04165131 ! molting cycle process GO:0022404 40 22 1,000 7,773E-03 0,04480584 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 7,773E-03 0,04469382 ! ureteric bud development GO:0001657 32 22 1,000 7,773E-03 0,04458237 ! leukocyte homeostasis GO:0001776 33 22 1,000 7,773E-03 0,04447147 ! aspartate family amino acid metabolic process GO:0009066 24 22 1,000 7,773E-03 0,04436112 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 7,836E-03 0,04461123 ! regulation of neuron differentiation GO:0045664 107 67 2,000 7,836E-03 0,04450108 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 8,48E-03 0,04803744 ! myelination GO:0042552 35 23 1,000 8,48E-03 0,04791942 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 8,48E-03 0,04780197 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 8,48E-03 0,04768509 ! lymphocyte proliferation GO:0046651 36 23 1,000 8,48E-03 0,04756879 ! group transfer coenzyme metabolic process GO:0006752 28 23 1,000 8,48E-03 0,04745305 ! telomere organization GO:0032200 32 23 1,000 8,48E-03 0,04733787 GO:0000723|telomere maintenance, ! response to drug GO:0042493 108 69 2,000 8,496E-03 0,04731447 ! eye development GO:0001654 111 70 2,000 8,838E-03 0,04909944 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 9,188E-03 0,05092001 ! muscle cell differentiation GO:0042692 104 71 2,000 9,188E-03 0,0507976 ! lymphocyte differentiation GO:0030098 113 71 2,000 9,188E-03 0,05067578 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 9,214E-03 0,05070011 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 9,214E-03 0,0505791 ! mitochondrial membrane organization GO:0007006 39 24 1,000 9,214E-03 0,05045868 ! neural crest cell development GO:0014032 39 24 1,000 9,214E-03 0,05033882 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 9,214E-03 0,05021954 ! negative regulation of cell development GO:0010721 56 24 1,000 9,214E-03 0,05010081 GO:0050768|negative regulation of neurogenesis, ! regulation of peptidase activity GO:0052547 106 72 2,000 9,546E-03 0,05178033 ! negative regulation of organelle organization GO:0010639 115 72 2,000 9,546E-03 0,05165849 ! negative regulation of transport GO:0051051 116 73 2,000 9,911E-03 0,05351273 ! tube morphogenesis GO:0035239 118 73 2,000 9,911E-03 0,05338741 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 9,911E-03 0,05326267 ! iron ion homeostasis GO:0055072 39 25 1,000 9,976E-03 0,05348494 ! regulation of peptide secretion GO:0002791 34 25 1,000 9,976E-03 0,05336056 ! regulation of chromosome organization GO:0033044 35 25 1,000 9,976E-03 0,05323675 ! response to estradiol stimulus GO:0032355 34 25 1,000 9,976E-03 0,05311352 ! positive regulation of nuclear division GO:0051785 39 25 1,000 9,976E-03 0,05299085 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 1,000 9,976E-03 0,05286875 GO:0032943|mononuclear cell proliferation, ! response to nutrient GO:0007584 104 75 2,000 0,01066756 0,05640319 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01076503 0,05678802 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01076503 0,05665807 ! post-embryonic development GO:0009791 42 26 1,000 0,01076503 0,05652871 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01076503 0,05639994 ! one-carbon metabolic process GO:0006730 110 77 2,000 0,01145621 0,05988475 ! carbohydrate biosynthetic process GO:0016051 97 77 2,000 0,01145621 0,05974896 ! membrane docking GO:0022406 39 27 1,000 0,01158063 0,0602612 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01158063 0,06012517 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01158063 0,05998975 ! T cell activation GO:0042110 134 79 2,000 0,01227768 0,06345766 ! cell junction assembly GO:0034329 56 28 1,000 0,01242255 0,06406248 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01242255 0,06391917 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01242255 0,06377649 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01242255 0,06363445 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01242255 0,06349304 GO:0008366|axon ensheathment, ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,01242255 0,06335225 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01242255 0,0632121 ! placenta development GO:0001890 37 28 1,000 0,01242255 0,06307255 ! forebrain development GO:0030900 131 80 2,000 0,01270078 0,06434317 ! response to protein stimulus GO:0051789 111 81 2,000 0,01313217 0,06638238 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01329045 0,06703517 ! ovulation cycle process GO:0022602 41 29 1,000 0,01329045 0,06688848 ! telencephalon development GO:0021537 52 29 1,000 0,01329045 0,06674244 ! tissue homeostasis GO:0001894 42 29 1,000 0,01329045 0,06659703 GO:0048871|multicellular organismal homeostasis, ! ossification GO:0001503 134 82 2,000 0,01357186 0,06785928 GO:0060348|bone development, ! collagen metabolic process GO:0032963 40 30 1,000 0,01418399 0,07076612 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,01418399 0,07061294 ! spindle organization GO:0007051 37 30 1,000 0,01418399 0,07046043 ! ovulation cycle GO:0042698 43 30 1,000 0,01418399 0,07030858 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01418399 0,07015738 ! response to heat GO:0009408 41 30 1,000 0,01418399 0,07000682 ! regulation of defense response GO:0031347 117 84 2,000 0,01447622 0,07129618 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01447622 0,07114384 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,01494094 0,07327115 ! regulation of protein localization GO:0032880 132 85 2,000 0,01494094 0,07311525 ! regulation of membrane potential GO:0042391 128 85 2,000 0,01494094 0,07296002 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,01494094 0,07280544 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,01510283 0,07343873 ! mammary gland development GO:0030879 57 31 1,000 0,01510283 0,0732838 ! odontogenesis GO:0042476 50 31 1,000 0,01510283 0,07312952 ! segmentation GO:0035282 41 31 1,000 0,01510283 0,07297588 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,01510283 0,07282289 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,01589554 0,07648481 ! regulation of muscle development GO:0048634 48 32 1,000 0,01604665 0,07705071 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,01604665 0,07689019 ! meiosis I GO:0007127 52 32 1,000 0,01604665 0,07673033 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01604665 0,07657114 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01604665 0,07641261 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,01688378 0,08023283 ! regulation of T cell activation GO:0050863 128 89 2,000 0,01688378 0,08006741 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,0170151 0,08052414 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,0170151 0,08035879 ! sister chromatid segregation GO:0000819 46 33 1,000 0,0170151 0,08019412 ! cell junction organization GO:0034330 63 33 1,000 0,0170151 0,08003013 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,0170151 0,0798668 ! female gonad development GO:0008585 49 33 1,000 0,0170151 0,07970414 ! positive regulation of cell development GO:0010720 54 33 1,000 0,0170151 0,07954214 ! cytokinesis GO:0000910 52 33 1,000 0,0170151 0,07938079 ! leukocyte differentiation GO:0002521 143 90 2,000 0,01739055 0,08096814 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,01800786 0,08367291 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,01800786 0,08350421 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01800786 0,08333619 ! female gamete generation GO:0007292 43 34 1,000 0,01800786 0,08316885 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,01800786 0,08300218 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,01800786 0,08283618 ! embryonic organ development GO:0048568 45 34 1,000 0,01800786 0,08267084 ! cell fate commitment GO:0045165 141 92 2,000 0,01842944 0,08443768 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,01902462 0,08699128 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,01902462 0,08681868 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01902462 0,08664676 ! pigment metabolic process GO:0042440 61 35 1,000 0,01902462 0,08647553 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,01902462 0,08630496 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! angiogenesis GO:0001525 149 95 2,000 0,02005129 0,09078342 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,02006503 0,09066714 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 1,000 0,02006503 0,09048936 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,02006503 0,09031228 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 1,000 0,02006503 0,09013589 ! glucan metabolic process GO:0044042 49 36 1,000 0,02006503 0,08996018 GO:0006073|cellular glucan metabolic process, ! in utero embryonic development GO:0001701 147 96 2,000 0,02060888 0,09221871 ! amino acid activation GO:0043038 52 37 1,000 0,0211288 0,09436161 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02221559 0,09902298 ! regulation of translation GO:0006417 151 100 2,000 0,02292413 0,10198355 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,0233251 0,10356706 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,0233251 0,10336751 ! chromatin remodeling GO:0006338 68 39 1,000 0,0233251 0,10316872 ! developmental growth GO:0048589 62 39 1,000 0,0233251 0,1029707 ! synapse organization GO:0050808 55 39 1,000 0,0233251 0,10277344 ! response to calcium ion GO:0051592 58 40 1,000 0,02445702 0,10755479 ! B cell differentiation GO:0030183 62 40 1,000 0,02445702 0,10734953 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,02445702 0,10714505 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,02561105 0,11198746 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,02561105 0,11177496 ! biopolymer methylation GO:0043414 62 41 1,000 0,02561105 0,11156327 ! mitochondrial transport GO:0006839 60 42 1,000 0,02678687 0,11646463 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,02678687 0,11624489 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,02678687 0,11602597 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,02678687 0,11580788 ! regulation of cell shape GO:0008360 78 42 1,000 0,02678687 0,1155906 ! positive regulation of binding GO:0051099 59 43 1,000 0,02798418 0,12053111 ! vesicle organization GO:0016050 79 43 1,000 0,02798418 0,12030582 ! response to insulin stimulus GO:0032868 63 43 1,000 0,02798418 0,12008137 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,02798418 0,11985776 ! methylation GO:0032259 64 43 1,000 0,02798418 0,11963497 ! regulation of action potential GO:0001508 71 44 1,000 0,02920269 0,1246126 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,02920269 0,12438184 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02995486 0,12734968 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02995486 0,12711472 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02995486 0,12688062 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02995486 0,12664738 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02995486 0,126415 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02995486 0,12618347 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02995486 0,12595279 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02995486 0,12572295 ! sleep GO:0030431 11 5 0,000 0,02995486 0,12549395 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02995486 0,12526578 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02995486 0,12503843 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02995486 0,12481192 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02995486 0,12458622 ! tongue development GO:0043586 6 5 0,000 0,02995486 0,12436133 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02995486 0,12413726 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02995486 0,12391399 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02995486 0,12369152 ! cobalt ion transport GO:0006824 9 5 0,000 0,02995486 0,12346985 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02995486 0,12324898 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02995486 0,12302889 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02995486 0,12280959 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02995486 0,12259106 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02995486 0,12237332 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02995486 0,12215634 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02995486 0,12194014 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02995486 0,12172469 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02995486 0,12151001 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02995486 0,12129609 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02995486 0,12108291 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02995486 0,12087049 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02995486 0,1206588 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02995486 0,12044786 ! malate metabolic process GO:0006108 7 5 0,000 0,02995486 0,12023766 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02995486 0,12002818 ! behavioral response to pain GO:0048266 7 5 0,000 0,02995486 0,11981944 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02995486 0,11961142 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02995486 0,11940412 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02995486 0,11919754 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02995486 0,11899167 ! mating behavior GO:0007617 6 5 0,000 0,02995486 0,11878651 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02995486 0,11858206 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02995486 0,11837831 ! rhythmic behavior GO:0007622 12 5 0,000 0,02995486 0,11817526 ! copulation GO:0007620 7 5 0,000 0,02995486 0,11797291 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02995486 0,11777124 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02995486 0,11757027 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02995486 0,11736998 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02995486 0,11717037 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02995486 0,11697144 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02995486 0,11677318 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02995486 0,1165756 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02995486 0,11637868 ! response to protozoan GO:0001562 9 5 0,000 0,02995486 0,11618242 ! lymph vessel development GO:0001945 7 5 0,000 0,02995486 0,11598683 ! endochondral ossification GO:0001958 12 5 0,000 0,02995486 0,11579189 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02995486 0,11559761 ! parathyroid gland development GO:0060017 8 5 0,000 0,02995486 0,11540398 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02995486 0,115211 ! anagen GO:0042640 6 5 0,000 0,02995486 0,11501866 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02995486 0,11482696 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02995486 0,1146359 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02995486 0,11444548 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02995486 0,11425568 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02995486 0,11406652 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02995486 0,11387798 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02995486 0,11369006 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02995486 0,11350276 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02995486 0,11331608 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02995486 0,11313001 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02995486 0,11294455 ! ovulation GO:0030728 6 5 0,000 0,02995486 0,1127597 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02995486 0,11257545 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,02995486 0,11239181 ! response to pH GO:0009268 9 5 0,000 0,02995486 0,11220876 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02995486 0,1120263 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02995486 0,11184444 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02995486 0,11166317 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02995486 0,11148249 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02995486 0,11130239 ! polyol catabolic process GO:0046174 7 5 0,000 0,02995486 0,11112287 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02995486 0,11094392 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02995486 0,11076556 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02995486 0,11058776 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02995486 0,11041054 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02995486 0,11023388 ! urea metabolic process GO:0019627 6 5 0,000 0,02995486 0,11005779 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02995486 0,10988226 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02995486 0,10970729 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02995486 0,10953287 ! neutrophil activation GO:0042119 5 5 0,000 0,02995486 0,10935901 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02995486 0,1091857 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02995486 0,10901294 ! response to food GO:0032094 5 5 0,000 0,02995486 0,10884072 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02995486 0,10866905 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02995486 0,10849792 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02995486 0,10832732 ! forebrain neuron development GO:0021884 7 5 0,000 0,02995486 0,10815726 ! melanosome organization GO:0032438 7 5 0,000 0,02995486 0,10798774 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02995486 0,10781874 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02995486 0,10765028 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02995486 0,10748234 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02995486 0,10731492 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02995486 0,10714802 ! nucleoside transport GO:0015858 6 5 0,000 0,02995486 0,10698164 ! nucleoside salvage GO:0043174 7 5 0,000 0,02995486 0,10681578 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02995486 0,10665043 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02995486 0,10648559 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02995486 0,10632126 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02995486 0,10615744 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02995486 0,10599412 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02995486 0,1058313 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02995486 0,10566898 ! depyrimidination GO:0045008 8 5 0,000 0,02995486 0,10550716 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02995486 0,10534584 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02995486 0,105185 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02995486 0,10502466 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02995486 0,10486481 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02995486 0,10470544 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02995486 0,10454655 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02995486 0,10438815 ! monocyte differentiation GO:0030224 8 5 0,000 0,02995486 0,10423022 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02995486 0,10407278 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02995486 0,1039158 ! centrosome duplication GO:0051298 5 5 0,000 0,02995486 0,1037593 ! response to UV-C GO:0010225 6 5 0,000 0,02995486 0,10360327 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02995486 0,10344771 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02995486 0,10329262 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02995486 0,10313799 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02995486 0,10298382 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02995486 0,10283012 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02995486 0,10267687 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02995486 0,10252407 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02995486 0,10237173 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02995486 0,10221985 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02995486 0,10206841 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02995486 0,10191742 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02995486 0,10176688 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02995486 0,10161678 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02995486 0,10146712 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02995486 0,10131791 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02995486 0,10116913 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02995486 0,10102079 ! neural tube patterning GO:0021532 6 5 0,000 0,02995486 0,10087288 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02995486 0,10072541 ! histone demethylation GO:0016577 9 5 0,000 0,02995486 0,10057836 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02995486 0,10043175 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02995486 0,10028556 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02995486 0,10013979 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02995486 0,09999445 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02995486 0,09984953 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02995486 0,09970503 ! transcription termination GO:0006353 8 5 0,000 0,02995486 0,09956095 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02995486 0,09941728 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02995486 0,09927403 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02995486 0,09913119 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,02995486 0,09898876 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02995486 0,09884674 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02995486 0,09870512 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02995486 0,09856392 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02995486 0,09842311 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02995486 0,09828271 ! apical protein localization GO:0045176 6 5 0,000 0,02995486 0,0981427 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02995486 0,0980031 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02995486 0,09786389 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02995486 0,09772507 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02995486 0,09758665 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02995486 0,09744862 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02995486 0,09731098 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02995486 0,09717373 ! glial cell migration GO:0008347 10 5 0,000 0,02995486 0,09703687 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02995486 0,09690039 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02995486 0,09676429 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02995486 0,09662858 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02995486 0,09649325 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02995486 0,09635829 ! neural plate development GO:0001840 6 5 0,000 0,02995486 0,09622371 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02995486 0,09608951 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02995486 0,09595568 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02995486 0,09582222 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02995486 0,09568914 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02995486 0,09555642 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02995486 0,09542407 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02995486 0,09529208 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02995486 0,09516047 ! spindle assembly GO:0051225 5 5 0,000 0,02995486 0,09502921 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02995486 0,09489832 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02995486 0,09476778 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02995486 0,09463761 ! organ regeneration GO:0031100 7 5 0,000 0,02995486 0,09450779 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02995486 0,09437832 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02995486 0,09424922 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02995486 0,09412046 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02995486 0,09399206 GO:0055081|anion homeostasis, ! vascular process in circulatory system GO:0003018 69 45 1,000 0,03044211 0,0953908 ! cell maturation GO:0048469 60 45 1,000 0,03044211 0,09526101 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,03170213 0,09906915 ! regulation of ossification GO:0030278 71 46 1,000 0,03170213 0,09893473 ! histone modification GO:0016570 68 46 1,000 0,03170213 0,09880067 ! covalent chromatin modification GO:0016569 75 47 1,000 0,03298247 0,10265179 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,03298247 0,10251308 ! response to temperature stimulus GO:0009266 62 48 1,000 0,03428284 0,10641097 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,03428284 0,10626756 ! heart morphogenesis GO:0003007 65 48 1,000 0,03428284 0,10612453 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,03428284 0,10598189 ! sulfur compound biosynthetic process GO:0044272 62 49 1,000 0,03560295 0,10991516 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,03560295 0,10976782 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,03560295 0,10962087 ! tRNA transcription GO:0009304 11 6 0,000 0,03583829 0,11019796 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03583829 0,11005084 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03583829 0,1099041 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03583829 0,10975776 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03583829 0,1096118 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03583829 0,10946624 ! regulation of helicase activity GO:0051095 11 6 0,000 0,03583829 0,10932106 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03583829 0,10917626 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03583829 0,10903185 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03583829 0,10888782 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03583829 0,10874416 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03583829 0,10860089 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03583829 0,108458 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03583829 0,10831548 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03583829 0,10817333 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03583829 0,10803156 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03583829 0,10789015 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03583829 0,10774912 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03583829 0,10760846 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03583829 0,10746816 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03583829 0,10732822 ! neuron adhesion GO:0007158 9 6 0,000 0,03583829 0,10718866 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03583829 0,10704945 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03583829 0,10691061 ! signal peptide processing GO:0006465 8 6 0,000 0,03583829 0,10677212 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03583829 0,10663399 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03583829 0,10649622 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03583829 0,10635881 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03583829 0,10622175 ! opsonization GO:0008228 8 6 0,000 0,03583829 0,10608504 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03583829 0,10594868 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03583829 0,10581268 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03583829 0,10567702 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03583829 0,10554171 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03583829 0,10540675 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03583829 0,10527213 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03583829 0,10513785 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03583829 0,10500392 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03583829 0,10487033 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03583829 0,10473707 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03583829 0,10460416 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03583829 0,10447158 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03583829 0,10433934 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03583829 0,10420743 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03583829 0,10407585 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03583829 0,10394461 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03583829 0,1038137 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03583829 0,10368312 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03583829 0,10355286 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03583829 0,10342293 ! thymic T cell selection GO:0045061 12 6 0,000 0,03583829 0,10329333 ! protein lipoylation GO:0009249 10 6 0,000 0,03583829 0,10316405 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03583829 0,1030351 ! drug transport GO:0015893 6 6 0,000 0,03583829 0,10290646 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03583829 0,10277815 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,03583829 0,10265016 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03583829 0,10252248 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03583829 0,10239513 ! glutamate catabolic process GO:0006538 10 6 0,000 0,03583829 0,10226809 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03583829 0,10214136 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03583829 0,10201495 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03583829 0,10188885 ! adenohypophysis development GO:0021984 10 6 0,000 0,03583829 0,10176306 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03583829 0,10163758 ! hyperosmotic response GO:0006972 8 6 0,000 0,03583829 0,10151241 ! microtubule nucleation GO:0007020 10 6 0,000 0,03583829 0,10138755 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03583829 0,10126299 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03583829 0,10113874 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03583829 0,1010148 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03583829 0,10089116 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03583829 0,10076782 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,03583829 0,10064478 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03583829 0,10052204 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03583829 0,10039961 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03583829 0,10027747 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03583829 0,10015562 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03583829 0,10003407 ! neuron apoptosis GO:0051402 8 6 0,000 0,03583829 0,09991282 ! organic alcohol transport GO:0015850 9 6 0,000 0,03583829 0,09979186 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03583829 0,09967119 ! male sex determination GO:0030238 9 6 0,000 0,03583829 0,09955082 ! carnitine transport GO:0015879 8 6 0,000 0,03583829 0,09943073 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03583829 0,09931094 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03583829 0,09919143 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03583829 0,09907221 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03583829 0,09895327 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03583829 0,09883462 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03583829 0,09871626 ! parturition GO:0007567 12 6 0,000 0,03583829 0,09859818 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03583829 0,09848038 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03583829 0,09836286 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03583829 0,09824562 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03583829 0,09812866 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03583829 0,09801198 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03583829 0,09789558 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03583829 0,09777945 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03583829 0,0976636 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03583829 0,09754802 ! macrophage differentiation GO:0030225 10 6 0,000 0,03583829 0,09743271 ! astrocyte development GO:0014002 14 6 0,000 0,03583829 0,09731768 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03583829 0,09720292 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03583829 0,09708843 ! interaction with symbiont GO:0051702 8 6 0,000 0,03583829 0,09697421 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03583829 0,09686025 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03583829 0,09674657 ! eating behavior GO:0042755 6 6 0,000 0,03583829 0,09663315 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03583829 0,09652 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03583829 0,09640711 ! response to copper ion GO:0046688 9 6 0,000 0,03583829 0,09629448 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03583829 0,09618212 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03583829 0,09607002 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03583829 0,09595818 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03583829 0,0958466 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03583829 0,09573528 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03583829 0,09562422 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03583829 0,09551341 ! hair follicle maturation GO:0048820 7 6 0,000 0,03583829 0,09540287 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03583829 0,09529257 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03583829 0,09518254 ! Schwann cell development GO:0014044 14 6 0,000 0,03583829 0,09507275 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03583829 0,09496322 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03583829 0,09485394 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03583829 0,09474492 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03583829 0,09463614 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03583829 0,09452761 ! histone ubiquitination GO:0016574 7 6 0,000 0,03583829 0,09441933 ! regulation of meiosis GO:0040020 10 6 0,000 0,03583829 0,0943113 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03583829 0,09420352 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03583829 0,09409598 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03583829 0,09398868 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03583829 0,09388164 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03583829 0,09377483 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03583829 0,09366827 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03583829 0,09356195 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03583829 0,09345587 ! receptor internalization GO:0031623 9 6 0,000 0,03583829 0,09335003 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03583829 0,09324443 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03583829 0,09313907 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03583829 0,09303395 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03583829 0,09292906 ! protein deubiquitination GO:0016579 8 6 0,000 0,03583829 0,09282441 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03583829 0,09272 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,03583829 0,09261582 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03583829 0,09251187 ! axonal fasciculation GO:0007413 9 6 0,000 0,03583829 0,09240816 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03583829 0,09230468 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03583829 0,09220143 ! midbrain development GO:0030901 6 6 0,000 0,03583829 0,09209841 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03583829 0,09199562 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03583829 0,09189306 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03583829 0,09179073 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03583829 0,09168863 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03583829 0,09158675 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03583829 0,0914851 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03583829 0,09138368 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03583829 0,09128248 ! adult feeding behavior GO:0008343 6 6 0,000 0,03583829 0,0911815 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03583829 0,09108075 ! blastocyst growth GO:0001832 15 6 0,000 0,03583829 0,09098022 ! pigment granule transport GO:0051904 12 6 0,000 0,03583829 0,09087991 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03583829 0,09077982 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03583829 0,09067995 ! catecholamine transport GO:0051937 7 6 0,000 0,03583829 0,0905803 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03583829 0,09048087 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03583829 0,09038166 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03583829 0,09028267 ! protein prenylation GO:0018342 10 6 0,000 0,03583829 0,09018389 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03583829 0,09008533 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03583829 0,08998698 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03583829 0,08988885 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03583829 0,08979093 ! ear development GO:0043583 72 50 1,000 0,03694253 0,09245682 ! membrane fusion GO:0006944 80 50 1,000 0,03694253 0,09235633 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,03694253 0,09225605 ! lipid modification GO:0030258 73 50 1,000 0,03694253 0,09215599 ! positive regulation of growth GO:0045927 67 50 1,000 0,03694253 0,09205614 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,03694253 0,09195652 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,03830129 0,09523565 ! positive regulation of secretion GO:0051047 71 51 1,000 0,03830129 0,0951328 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,03830129 0,09503018 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03967896 0,09834225 ! establishment of organelle localization GO:0051656 85 52 1,000 0,03967896 0,09823639 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,04107526 0,10158397 ! cell projection assembly GO:0030031 76 53 1,000 0,04107526 0,10147486 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04168638 0,10287411 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04168638 0,10276385 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04168638 0,10265383 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04168638 0,10254404 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04168638 0,10243448 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04168638 0,10232516 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04168638 0,10221607 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04168638 0,10210721 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04168638 0,10199859 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04168638 0,10189019 ! reproductive behavior GO:0019098 12 7 0,000 0,04168638 0,10178203 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04168638 0,1016741 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04168638 0,10156639 ! oligopeptide transport GO:0006857 11 7 0,000 0,04168638 0,10145891 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04168638 0,10135166 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04168638 0,10124464 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04168638 0,10113784 ! RNA methylation GO:0001510 11 7 0,000 0,04168638 0,10103127 ! pericardium development GO:0060039 8 7 0,000 0,04168638 0,10092492 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04168638 0,10081879 ! fibril organization GO:0043206 13 7 0,000 0,04168638 0,10071289 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04168638 0,10060721 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04168638 0,10050175 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,04168638 0,10039652 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04168638 0,1002915 ! lipoprotein transport GO:0042953 9 7 0,000 0,04168638 0,1001867 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04168638 0,10008212 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04168638 0,09997776 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04168638 0,09987362 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04168638 0,09976969 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04168638 0,09966598 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04168638 0,09956249 ! chemosensory behavior GO:0007635 9 7 0,000 0,04168638 0,0994592 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04168638 0,09935614 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04168638 0,09925328 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04168638 0,09915064 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04168638 0,09904822 ! reflex GO:0060004 12 7 0,000 0,04168638 0,098946 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04168638 0,09884399 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04168638 0,0987422 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04168638 0,09864061 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04168638 0,09853923 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04168638 0,09843806 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04168638 0,0983371 ! spinal cord patterning GO:0021511 7 7 0,000 0,04168638 0,09823635 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04168638 0,0981358 ! adrenal gland development GO:0030325 17 7 0,000 0,04168638 0,09803545 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04168638 0,09793531 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04168638 0,09783538 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04168638 0,09773565 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04168638 0,09763612 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04168638 0,0975368 ! endosome organization GO:0007032 10 7 0,000 0,04168638 0,09743768 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04168638 0,09733875 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04168638 0,09724003 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04168638 0,09714151 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04168638 0,09704319 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04168638 0,09694507 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04168638 0,09684714 ! galactose metabolic process GO:0006012 10 7 0,000 0,04168638 0,09674942 ! vesicle fusion GO:0006906 15 7 0,000 0,04168638 0,09665189 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04168638 0,09655455 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04168638 0,09645742 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04168638 0,09636048 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04168638 0,09626373 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04168638 0,09616717 ! retinol metabolic process GO:0042572 9 7 0,000 0,04168638 0,09607081 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04168638 0,09597465 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04168638 0,09587867 ! rRNA modification GO:0000154 12 7 0,000 0,04168638 0,09578289 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04168638 0,0956873 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04168638 0,0955919 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04168638 0,09549669 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04168638 0,09540166 ! intermediate filament organization GO:0045109 11 7 0,000 0,04168638 0,09530683 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04168638 0,09521219 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04168638 0,09511773 ! fibrinolysis GO:0042730 9 7 0,000 0,04168638 0,09502346 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04168638 0,09492938 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04168638 0,09483548 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04168638 0,09474177 ! response to tropane GO:0014073 13 7 0,000 0,04168638 0,09464825 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04168638 0,0945549 ! melanosome localization GO:0032400 10 7 0,000 0,04168638 0,09446175 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04168638 0,09436877 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04168638 0,09427598 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04168638 0,09418337 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04168638 0,09409095 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04168638 0,0939987 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04168638 0,09390663 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04168638 0,09381475 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04168638 0,09372304 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04168638 0,09363152 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04168638 0,09354017 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04168638 0,093449 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04168638 0,09335801 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04168638 0,09326719 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04168638 0,09317655 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04168638 0,09308609 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04168638 0,0929958 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04168638 0,09290569 ! response to tumor cell GO:0002347 12 7 0,000 0,04168638 0,09281575 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04168638 0,09272599 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04168638 0,0926364 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04168638 0,09254698 ! diuresis GO:0030146 12 7 0,000 0,04168638 0,09245774 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04168638 0,09236866 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04168638 0,09227976 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04168638 0,09219103 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04168638 0,09210247 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04168638 0,09201408 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04168638 0,09192586 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04168638 0,09183781 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04168638 0,09174993 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04168638 0,09166221 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04168638 0,09157466 ! lymph node development GO:0048535 9 7 0,000 0,04168638 0,09148728 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04168638 0,09140007 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04168638 0,09131302 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04168638 0,09122614 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04168638 0,09113942 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04168638 0,09105287 ! ATP catabolic process GO:0006200 10 7 0,000 0,04168638 0,09096648 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04168638 0,09088026 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04168638 0,0907942 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04168638 0,0907083 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04168638 0,09062256 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04168638 0,09053699 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04168638 0,09045158 ! muscle adaptation GO:0043500 12 7 0,000 0,04168638 0,09036633 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04168638 0,09028124 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04168638 0,09019631 ! retina homeostasis GO:0001895 9 7 0,000 0,04168638 0,09011153 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04168638 0,09002692 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04168638 0,08994247 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04168638 0,08985818 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04168638 0,08977404 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04168638 0,08969006 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04168638 0,08960624 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04168638 0,08952257 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,04248992 0,09116307 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,04248992 0,09107811 ! DNA catabolic process GO:0006308 67 54 1,000 0,04248992 0,09099331 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,04248992 0,09090866 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,04248992 0,09082417 ! exocytosis GO:0006887 74 55 1,000 0,04392267 0,09379957 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,04537324 0,09680747 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,04537324 0,09671775 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,04684137 0,09975478 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 1,000 0,04684137 0,0996625 ! camera-type eye development GO:0043010 88 57 1,000 0,04684137 0,09957039 ! secondary metabolic process GO:0019748 84 57 1,000 0,04684137 0,09947845 ! developmental maturation GO:0021700 75 57 1,000 0,04684137 0,09938668 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04749933 0,10068982 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04749933 0,1005971 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04749933 0,10050455 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04749933 0,10041218 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04749933 0,10031997 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04749933 0,10022794 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04749933 0,10013607 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04749933 0,10004437 ! phosphate transport GO:0006817 10 8 0,000 0,04749933 0,09995284 ! N-glycan processing GO:0006491 12 8 0,000 0,04749933 0,09986147 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04749933 0,09977027 ! UTP metabolic process GO:0046051 8 8 0,000 0,04749933 0,09967924 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04749933 0,09958838 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04749933 0,09949768 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04749933 0,09940714 ! succinate metabolic process GO:0006105 14 8 0,000 0,04749933 0,09931677 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04749933 0,09922657 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04749933 0,09913652 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,04749933 0,09904665 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04749933 0,09895693 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,04749933 0,09886738 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04749933 0,09877798 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04749933 0,09868875 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04749933 0,09859968 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04749933 0,09851078 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,04749933 0,09842203 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04749933 0,09833344 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04749933 0,09824501 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04749933 0,09815674 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04749933 0,09806863 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04749933 0,09798067 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04749933 0,09789288 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04749933 0,09780524 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04749933 0,09771776 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04749933 0,09763043 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04749933 0,09754326 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04749933 0,09745624 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04749933 0,09736939 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04749933 0,09728268 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04749933 0,09719613 ! macrophage activation GO:0042116 12 8 0,000 0,04749933 0,09710973 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04749933 0,09702349 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04749933 0,0969374 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04749933 0,09685146 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04749933 0,09676568 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04749933 0,09668004 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04749933 0,09659456 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04749933 0,09650923 ! ruffle organization GO:0031529 11 8 0,000 0,04749933 0,09642405 ! osteoblast development GO:0002076 13 8 0,000 0,04749933 0,09633902 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04749933 0,09625414 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04749933 0,09616941 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04749933 0,09608483 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04749933 0,0960004 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04749933 0,09591611 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04749933 0,09583197 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04749933 0,09574798 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04749933 0,09566414 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04749933 0,09558045 ! brain morphogenesis GO:0048854 20 8 0,000 0,04749933 0,0954969 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04749933 0,09541349 ! segment specification GO:0007379 10 8 0,000 0,04749933 0,09533024 ! cellular extravasation GO:0045123 11 8 0,000 0,04749933 0,09524712 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04749933 0,09516416 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04749933 0,09508133 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04749933 0,09499865 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04749933 0,09491612 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04749933 0,09483372 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04749933 0,09475147 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04749933 0,09466937 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04749933 0,0945874 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04749933 0,09450558 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04749933 0,0944239 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04749933 0,09434236 ! icosanoid secretion GO:0032309 12 8 0,000 0,04749933 0,09426096 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04749933 0,0941797 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04749933 0,09409858 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04749933 0,0940176 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04749933 0,09393676 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04749933 0,09385606 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04749933 0,09377549 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04749933 0,09369507 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04749933 0,09361478 ! sterol catabolic process GO:0016127 9 8 0,000 0,04749933 0,09353463 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04749933 0,09345462 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04749933 0,09337474 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04749933 0,093295 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04749933 0,0932154 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04749933 0,09313593 ! prophase GO:0051324 11 8 0,000 0,04749933 0,0930566 ! S phase GO:0051320 8 8 0,000 0,04749933 0,0929774 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04749933 0,09289834 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04749933 0,09281941 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04749933 0,09274062 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04749933 0,09266196 ! hormone catabolic process GO:0042447 13 8 0,000 0,04749933 0,09258343 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04749933 0,09250504 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04749933 0,09242678 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04749933 0,09234865 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04749933 0,09227065 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04749933 0,09219279 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,04749933 0,09211505 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04749933 0,09203745 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04749933 0,09195998 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04749933 0,09188263 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04749933 0,09180542 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04749933 0,09172834 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04749933 0,09165138 ! regulation of embryonic development GO:0045995 16 8 0,000 0,04749933 0,09157456 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04749933 0,09149786 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04749933 0,0914213 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,04982927 0,09582553 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,04982927 0,09574547 ! actin filament organization GO:0007015 95 59 1,000 0,04982927 0,09566555 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,05134853 0,09850009 ! meiosis GO:0007126 96 61 1,000 0,0528843 0,10136158 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,0528843 0,10127718 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,0528843 0,10119293 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05327734 0,10186026 ! regulation of developmental growth GO:0048638 13 9 0,000 0,05327734 0,10177566 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05327734 0,10169119 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05327734 0,10160687 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05327734 0,10152269 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05327734 0,10143865 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05327734 0,10135475 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05327734 0,10127098 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05327734 0,10118736 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,05327734 0,10110387 ! GTP metabolic process GO:0046039 9 9 0,000 0,05327734 0,10102052 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05327734 0,10093731 ! social behavior GO:0035176 14 9 0,000 0,05327734 0,10085423 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05327734 0,10077129 ! artery development GO:0060840 19 9 0,000 0,05327734 0,10068849 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05327734 0,10060582 ! response to pain GO:0048265 16 9 0,000 0,05327734 0,10052329 ! protein complex disassembly GO:0043241 17 9 0,000 0,05327734 0,10044089 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05327734 0,10035863 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05327734 0,10027651 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05327734 0,10019451 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05327734 0,10011266 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,05327734 0,10003093 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05327734 0,09994934 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05327734 0,09986788 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05327734 0,09978656 ! protein targeting to ER GO:0045047 19 9 0,000 0,05327734 0,09970536 ! endoderm development GO:0007492 12 9 0,000 0,05327734 0,0996243 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05327734 0,09954337 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05327734 0,09946257 ! arginine catabolic process GO:0006527 10 9 0,000 0,05327734 0,09938191 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05327734 0,09930137 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05327734 0,09922096 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05327734 0,09914069 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05327734 0,09906054 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05327734 0,09898052 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05327734 0,09890064 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05327734 0,09882088 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05327734 0,09874125 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05327734 0,09866175 ! mannose metabolic process GO:0006013 9 9 0,000 0,05327734 0,09858237 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05327734 0,09850313 ! receptor clustering GO:0043113 15 9 0,000 0,05327734 0,09842401 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05327734 0,09834502 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05327734 0,09826615 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05327734 0,09818741 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05327734 0,0981088 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05327734 0,09803031 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05327734 0,09795195 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05327734 0,09787371 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05327734 0,0977956 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05327734 0,09771762 ! response to amine stimulus GO:0014075 13 9 0,000 0,05327734 0,09763975 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05327734 0,09756201 ! erythrocyte development GO:0048821 11 9 0,000 0,05327734 0,0974844 ! renal water homeostasis GO:0003091 14 9 0,000 0,05327734 0,09740691 ! postreplication repair GO:0006301 11 9 0,000 0,05327734 0,09732954 ! mRNA cleavage GO:0006379 13 9 0,000 0,05327734 0,09725229 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05327734 0,09717517 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05327734 0,09709817 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05327734 0,09702129 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05327734 0,09694453 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05327734 0,0968679 ! acid secretion GO:0046717 14 9 0,000 0,05327734 0,09679138 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05327734 0,09671499 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05327734 0,09663871 ! purine base metabolic process GO:0006144 18 9 0,000 0,05327734 0,09656256 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05327734 0,09648653 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,05327734 0,09641061 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05327734 0,09633482 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05327734 0,09625914 ! detection of calcium ion GO:0005513 13 9 0,000 0,05327734 0,09618359 ! blastocyst formation GO:0001825 12 9 0,000 0,05327734 0,09610815 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05327734 0,09603283 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05327734 0,09595763 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05327734 0,09588254 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05327734 0,09580758 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05327734 0,09573273 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05327734 0,09565799 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05327734 0,09558338 ! prepulse inhibition GO:0060134 14 9 0,000 0,05327734 0,09550888 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05327734 0,09543449 ! insulin secretion GO:0030073 17 9 0,000 0,05327734 0,09536023 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05327734 0,09528607 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05327734 0,09521204 ! nucleus localization GO:0051647 15 9 0,000 0,05327734 0,09513811 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05327734 0,09506431 ! amine catabolic process GO:0009310 90 62 1,000 0,05443636 0,09705707 ! meiotic cell cycle GO:0051321 97 62 1,000 0,05443636 0,09698189 ! organelle localization GO:0051640 96 62 1,000 0,05443636 0,09690683 ! regulation of lipase activity GO:0060191 109 63 1,000 0,05600443 0,09962119 ! adaptive immune response GO:0002250 94 64 1,000 0,05758829 0,10235941 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of muscle development GO:0048635 12 10 0,000 0,05902064 0,1048243 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05902064 0,10474342 ! neuron fate specification GO:0048665 11 10 0,000 0,05902064 0,10466266 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05902064 0,10458203 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05902064 0,10450152 ! thyroid gland development GO:0030878 19 10 0,000 0,05902064 0,10442113 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05902064 0,10434087 ! synapsis GO:0007129 13 10 0,000 0,05902064 0,10426073 GO:0070192|chromosome organization involved in meiosis, ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05902064 0,10418071 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05902064 0,10410082 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,05902064 0,10402105 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05902064 0,1039414 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,05902064 0,10386187 ! androgen metabolic process GO:0008209 13 10 0,000 0,05902064 0,10378247 ! phospholipid efflux GO:0033700 16 10 0,000 0,05902064 0,10370319 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,05902064 0,10362402 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05902064 0,10354498 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05902064 0,10346606 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,05902064 0,10338726 ! pathogenesis GO:0009405 13 10 0,000 0,05902064 0,10330858 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05902064 0,10323001 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05902064 0,10315157 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05902064 0,10307325 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05902064 0,10299505 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05902064 0,10291696 ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05902064 0,10283899 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05902064 0,10276114 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05902064 0,10268341 ! response to X-ray GO:0010165 16 10 0,000 0,05902064 0,1026058 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05902064 0,1025283 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05902064 0,10245092 ! forebrain cell migration GO:0021885 17 10 0,000 0,05902064 0,10237366 ! lipid digestion GO:0044241 15 10 0,000 0,05902064 0,10229651 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05902064 0,10221948 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05902064 0,10214257 ! UV protection GO:0009650 14 10 0,000 0,05902064 0,10206577 ! entry into host cell GO:0030260 20 10 0,000 0,05902064 0,10198908 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05902064 0,10191251 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,05902064 0,10183606 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05902064 0,10175972 ! regulation of organ growth GO:0046620 11 10 0,000 0,05902064 0,1016835 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05902064 0,10160739 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05902064 0,10153139 ! embryonic axis specification GO:0000578 12 10 0,000 0,05902064 0,10145551 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05902064 0,10137974 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05902064 0,10130408 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05902064 0,10122854 ! fucose catabolic process GO:0019317 16 10 0,000 0,05902064 0,10115311 GO:0042355|L-fucose catabolic process, ! protein sumoylation GO:0016925 12 10 0,000 0,05902064 0,10107779 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05902064 0,10100258 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05902064 0,10092749 ! zymogen activation GO:0031638 14 10 0,000 0,05902064 0,1008525 ! salivary gland development GO:0007431 22 10 0,000 0,05902064 0,10077763 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05902064 0,10070287 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05902064 0,10062822 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05902064 0,10055368 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05902064 0,10047925 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05902064 0,10040493 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05902064 0,10033072 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05902064 0,10025662 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05902064 0,10018263 ! detection of bacterium GO:0016045 10 10 0,000 0,05902064 0,10010875 ! embryonic gut development GO:0048566 11 10 0,000 0,05902064 0,10003498 ! activation of innate immune response GO:0002218 10 10 0,000 0,05902064 0,09996132 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05902064 0,09988776 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05902064 0,09981432 ! developmental induction GO:0031128 13 10 0,000 0,05902064 0,09974098 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05902064 0,09966775 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05902064 0,09959462 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05902064 0,09952161 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05902064 0,0994487 ! B cell activation GO:0042113 104 65 1,000 0,05918768 0,09965715 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,06080236 0,10230098 ! axon guidance GO:0007411 99 66 1,000 0,06080236 0,1022262 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,06080236 0,10215152 ! learning or memory GO:0007611 123 68 1,000 0,06407664 0,10757392 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,06407664 0,10749546 ! rhythmic process GO:0048511 105 68 1,000 0,06407664 0,10741711 ! rRNA transcription GO:0009303 17 11 0,000 0,06472942 0,10843238 ! respiratory burst GO:0045730 14 11 0,000 0,06472942 0,10835347 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,06472942 0,10827467 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,06472942 0,10819598 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,06472942 0,1081174 ! virus-host interaction GO:0019048 17 11 0,000 0,06472942 0,10803894 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,06472942 0,1079606 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,06472942 0,10788237 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,06472942 0,10780425 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,06472942 0,10772624 ! mating GO:0007618 14 11 0,000 0,06472942 0,10764835 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,06472942 0,10757057 ! T cell proliferation GO:0042098 20 11 0,000 0,06472942 0,1074929 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,06472942 0,10741534 ! bone resorption GO:0045453 16 11 0,000 0,06472942 0,1073379 ! regulated secretory pathway GO:0045055 14 11 0,000 0,06472942 0,10726057 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,06472942 0,10718334 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,06472942 0,10710623 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,06472942 0,10702923 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,06472942 0,10695235 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,06472942 0,10687557 ! syncytium formation GO:0006949 15 11 0,000 0,06472942 0,1067989 ! plasma membrane organization GO:0007009 18 11 0,000 0,06472942 0,10672234 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,06472942 0,10664589 ! mitotic spindle organization GO:0007052 15 11 0,000 0,06472942 0,10656955 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,06472942 0,10649332 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,06472942 0,1064172 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,06472942 0,10634119 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,06472942 0,10626529 ! adult heart development GO:0007512 11 11 0,000 0,06472942 0,10618949 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,06472942 0,1061138 ! temperature homeostasis GO:0001659 16 11 0,000 0,06472942 0,10603822 ! L-glutamate transport GO:0015813 16 11 0,000 0,06472942 0,10596275 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,06472942 0,10588739 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,06472942 0,10581213 ! stem cell development GO:0048864 29 11 0,000 0,06472942 0,10573698 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,06472942 0,10566193 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,06472942 0,105587 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,06472942 0,10551216 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,06472942 0,10543744 ! vasoconstriction GO:0042310 15 11 0,000 0,06472942 0,10536282 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,06472942 0,10528831 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,06472942 0,1052139 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,06472942 0,10513959 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,06472942 0,10506539 ! ribosome assembly GO:0042255 13 11 0,000 0,06472942 0,1049913 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,06472942 0,10491731 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,06472942 0,10484343 ! chromatin silencing GO:0006342 19 11 0,000 0,06472942 0,10476964 ! nucleosome positioning GO:0016584 13 11 0,000 0,06472942 0,10469597 ! regulation of isotype switching GO:0045191 19 11 0,000 0,06472942 0,10462239 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,06472942 0,10454892 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,06472942 0,10447555 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,06472942 0,10440229 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,06472942 0,10432913 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,06472942 0,10425607 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,06472942 0,10418311 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,06472942 0,10411025 ! cholesterol efflux GO:0033344 19 11 0,000 0,06472942 0,1040375 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,06472942 0,10396485 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,06472942 0,1038923 ! germ cell migration GO:0008354 18 11 0,000 0,06472942 0,10381985 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,06472942 0,1037475 ! defense response to fungus GO:0050832 12 11 0,000 0,06472942 0,10367525 ! lysogeny GO:0030069 18 11 0,000 0,06472942 0,10360311 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,06472942 0,10353106 ! acrosome reaction GO:0007340 13 11 0,000 0,06472942 0,10345911 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,06472942 0,10338727 ! humoral immune response GO:0006959 86 70 1,000 0,06740923 0,1075928 ! regulation of catabolic process GO:0009894 106 70 1,000 0,06740923 0,10751819 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,06909681 0,11013352 ! lactation GO:0007595 20 12 0,000 0,07040389 0,11213916 ! reproductive cellular process GO:0048610 14 12 0,000 0,07040389 0,11206156 ! tRNA modification GO:0006400 14 12 0,000 0,07040389 0,11198406 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,07040389 0,11190667 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,07040389 0,11182938 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,07040389 0,11175221 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,07040389 0,11167514 ! non-recombinational repair GO:0000726 19 12 0,000 0,07040389 0,11159817 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,07040389 0,11152131 ! peroxisomal transport GO:0043574 21 12 0,000 0,07040389 0,11144456 ! cartilage condensation GO:0001502 18 12 0,000 0,07040389 0,11136791 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,07040389 0,11129137 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,07040389 0,11121494 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,07040389 0,11113861 ! palate development GO:0060021 15 12 0,000 0,07040389 0,11106238 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,07040389 0,11098626 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,07040389 0,11091024 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,07040389 0,11083432 ! arginine metabolic process GO:0006525 13 12 0,000 0,07040389 0,11075851 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,07040389 0,11068281 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,07040389 0,1106072 ! Golgi organization GO:0007030 18 12 0,000 0,07040389 0,1105317 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,07040389 0,11045631 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,07040389 0,11038101 ! monoamine transport GO:0015844 13 12 0,000 0,07040389 0,11030582 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07040389 0,11023073 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,07040389 0,11015575 ! L-amino acid transport GO:0015807 20 12 0,000 0,07040389 0,11008086 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,07040389 0,11000608 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,07040389 0,1099314 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,07040389 0,10985682 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07040389 0,10978234 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,07040389 0,10970796 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,07040389 0,10963368 ! cerebellum development GO:0021549 13 12 0,000 0,07040389 0,1095595 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,07040389 0,10948543 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,07040389 0,10941145 ! histone methylation GO:0016571 15 12 0,000 0,07040389 0,10933757 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,07040389 0,1092638 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,07040389 0,10919012 ! intestinal absorption GO:0050892 19 12 0,000 0,07040389 0,10911654 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,07040389 0,10904306 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,07040389 0,10896968 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,07040389 0,1088964 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,07040389 0,10882322 ! microspike assembly GO:0030035 23 12 0,000 0,07040389 0,10875013 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,07040389 0,10867715 ! response to cold GO:0009409 14 12 0,000 0,07040389 0,10860426 ! digestion GO:0007586 97 74 1,000 0,07424195 0,11444804 ! protein import into nucleus GO:0006606 118 74 1,000 0,07424195 0,11437139 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,07424195 0,11429483 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,07424195 0,11421838 ! regulation of ligase activity GO:0051340 114 75 1,000 0,07598371 0,11681988 ! nuclear import GO:0051170 121 75 1,000 0,07598371 0,11674184 ! cofactor biosynthetic process GO:0051188 92 75 1,000 0,07598371 0,11666391 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07604426 0,11667898 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07604426 0,11660119 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07604426 0,11652351 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,07604426 0,11644593 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07604426 0,11636846 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07604426 0,11629108 ! lipid localization GO:0010876 24 13 0,000 0,07604426 0,11621381 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07604426 0,11613665 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07604426 0,11605958 ! organelle fusion GO:0048284 28 13 0,000 0,07604426 0,11598262 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07604426 0,11590576 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,07604426 0,115829 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,07604426 0,11575234 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07604426 0,11567579 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07604426 0,11559933 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07604426 0,11552298 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07604426 0,11544673 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07604426 0,11537057 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07604426 0,11529452 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07604426 0,11521857 ! NAD metabolic process GO:0019674 21 13 0,000 0,07604426 0,11514272 ! exocrine system development GO:0035272 27 13 0,000 0,07604426 0,11506697 ! bone mineralization GO:0030282 15 13 0,000 0,07604426 0,11499131 ! regulation of exocytosis GO:0017157 17 13 0,000 0,07604426 0,11491576 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,07604426 0,11484031 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07604426 0,11476495 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07604426 0,1146897 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07604426 0,11461454 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,07604426 0,11453948 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,07604426 0,11446452 ! regulation of cellular pH GO:0030641 20 13 0,000 0,07604426 0,11438966 ! tissue regeneration GO:0042246 21 13 0,000 0,07604426 0,11431489 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,07604426 0,11424023 ! cofactor transport GO:0051181 19 13 0,000 0,07604426 0,11416566 ! NADP metabolic process GO:0006739 18 13 0,000 0,07604426 0,11409119 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07604426 0,11401681 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,07604426 0,11394253 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07604426 0,11386835 ! gas transport GO:0015669 18 13 0,000 0,07604426 0,11379427 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07604426 0,11372028 ! regulation of axon extension GO:0030516 23 13 0,000 0,07604426 0,11364639 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07604426 0,11357259 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07604426 0,11349889 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07604426 0,11342528 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07604426 0,11335177 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07604426 0,11327836 ! amine biosynthetic process GO:0009309 97 76 1,000 0,07773847 0,11572717 ! tRNA metabolic process GO:0006399 95 76 1,000 0,07773847 0,11565231 ! response to unfolded protein GO:0006986 99 76 1,000 0,07773847 0,11557755 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,07773847 0,11550289 ! regulation of protein transport GO:0051223 114 76 1,000 0,07773847 0,11542832 GO:0070201|regulation of establishment of protein localization, ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,08128608 0,12061805 ! superoxide anion generation GO:0042554 18 14 0,000 0,08165072 0,12108102 ! neuron maturation GO:0042551 21 14 0,000 0,08165072 0,121003 ! regulation of S phase GO:0033261 18 14 0,000 0,08165072 0,12092508 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,08165072 0,12084727 ! myotube differentiation GO:0014902 21 14 0,000 0,08165072 0,12076955 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08165072 0,12069194 ! inositol metabolic process GO:0006020 20 14 0,000 0,08165072 0,12061442 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08165072 0,12053701 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08165072 0,12045969 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08165072 0,12038247 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08165072 0,12030535 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08165072 0,12022833 ! response to cAMP GO:0051591 19 14 0,000 0,08165072 0,12015141 ! startle response GO:0001964 21 14 0,000 0,08165072 0,12007459 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,08165072 0,11999786 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08165072 0,11992124 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,08165072 0,11984471 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08165072 0,11976827 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08165072 0,11969194 ! glycine metabolic process GO:0006544 22 14 0,000 0,08165072 0,1196157 ! pituitary gland development GO:0021983 23 14 0,000 0,08165072 0,11953956 ! cellular response to starvation GO:0009267 21 14 0,000 0,08165072 0,11946352 ! lysosomal transport GO:0007041 20 14 0,000 0,08165072 0,11938757 ! regulation of heart rate GO:0002027 23 14 0,000 0,08165072 0,11931172 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08165072 0,11923597 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08165072 0,11916031 ! embryo implantation GO:0007566 27 14 0,000 0,08165072 0,11908475 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,08165072 0,11900929 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,08165072 0,11893392 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08165072 0,11885864 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08165072 0,11878346 ! axon cargo transport GO:0008088 27 14 0,000 0,08165072 0,11870838 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08165072 0,11863339 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,08165072 0,11855849 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08165072 0,11848369 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08165072 0,11840899 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08165072 0,11833438 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08165072 0,11825986 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08165072 0,11818543 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,08165072 0,1181111 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08165072 0,11803687 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08165072 0,11796272 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,08165072 0,11788867 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08165072 0,11781471 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08165072 0,11774085 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08165072 0,11766708 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,08165072 0,1175934 ! cell killing GO:0001906 20 14 0,000 0,08165072 0,11751981 ! cilium assembly GO:0042384 20 14 0,000 0,08165072 0,11744631 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08165072 0,11737291 ! protein localization in nucleus GO:0034504 133 80 1,000 0,08488306 0,12194318 ! mRNA transport GO:0051028 121 81 1,000 0,08669954 0,12447499 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,08669954 0,12439734 GO:0002696|positive regulation of leukocyte activation, ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,08722348 0,12507108 ! positive regulation of cell size GO:0045793 20 15 0,000 0,08722348 0,12499315 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,08722348 0,12491532 ! skin development GO:0043588 25 15 0,000 0,08722348 0,12483759 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08722348 0,12475996 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,08722348 0,12468242 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,08722348 0,12460497 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08722348 0,12452763 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08722348 0,12445038 ! bile acid metabolic process GO:0008206 22 15 0,000 0,08722348 0,12437322 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08722348 0,12429616 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08722348 0,1242192 ! adult walking behavior GO:0007628 25 15 0,000 0,08722348 0,12414233 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08722348 0,12406556 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,08722348 0,12398888 ! centrosome cycle GO:0007098 16 15 0,000 0,08722348 0,1239123 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,08722348 0,12383581 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,08722348 0,12375941 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08722348 0,12368311 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08722348 0,12360691 ! cerebral cortex development GO:0021987 29 15 0,000 0,08722348 0,12353079 ! response to osmotic stress GO:0006970 22 15 0,000 0,08722348 0,12345477 ! vesicle coating GO:0006901 25 15 0,000 0,08722348 0,12337885 ! DNA integration GO:0015074 22 15 0,000 0,08722348 0,12330302 ! peptide secretion GO:0002790 27 15 0,000 0,08722348 0,12322728 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08722348 0,12315163 ! regulation of vasodilation GO:0042312 24 15 0,000 0,08722348 0,12307608 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,08722348 0,12300062 ! neuron recognition GO:0008038 22 15 0,000 0,08722348 0,12292525 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08722348 0,12284998 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08722348 0,12277479 ! biomineral formation GO:0031214 18 15 0,000 0,08722348 0,1226997 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,08722348 0,1226247 ! dopamine metabolic process GO:0042417 30 15 0,000 0,08722348 0,12254979 ! organic cation transport GO:0015695 19 15 0,000 0,08722348 0,12247498 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08722348 0,12240025 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,08722348 0,12232562 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,08722348 0,12225107 ! peptide hormone processing GO:0016486 19 15 0,000 0,08722348 0,12217662 ! protein secretion GO:0009306 27 16 0,000 0,09276275 0,12985655 ! hormone secretion GO:0046879 25 16 0,000 0,09276275 0,12977756 ! bone remodeling GO:0046849 24 16 0,000 0,09276275 0,12969867 ! endothelial cell migration GO:0043542 22 16 0,000 0,09276275 0,12961988 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,09276275 0,12954117 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09276275 0,12946257 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,09276275 0,12938406 ! glial cell development GO:0021782 24 16 0,000 0,09276275 0,12930565 ! patterning of blood vessels GO:0001569 24 16 0,000 0,09276275 0,12922733 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,09276275 0,1291491 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,09276275 0,12907097 ! protein polyubiquitination GO:0000209 26 16 0,000 0,09276275 0,12899294 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,09276275 0,12891499 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,09276275 0,12883715 ! fructose metabolic process GO:0006000 20 16 0,000 0,09276275 0,12875939 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,09276275 0,12868173 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,09276275 0,12860417 ! protein export from nucleus GO:0006611 24 16 0,000 0,09276275 0,1285267 ! negative regulation of immune response GO:0050777 28 16 0,000 0,09276275 0,12844932 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,09276275 0,12837203 ! DNA replication initiation GO:0006270 25 16 0,000 0,09276275 0,12829484 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,09276275 0,12821774 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,09276275 0,12814073 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,09276275 0,12806381 ! diencephalon development GO:0021536 25 16 0,000 0,09276275 0,12798699 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,09276275 0,12791026 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,09276275 0,12783362 ! steroid catabolic process GO:0006706 22 16 0,000 0,09276275 0,12775707 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,09276275 0,12768062 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,09276275 0,12760426 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,09276275 0,12752798 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,09276275 0,1274518 ! sperm-egg recognition GO:0035036 16 16 0,000 0,09276275 0,12737571 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,09276275 0,12729971 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,09276275 0,1272238 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,09276275 0,12714798 ! rRNA metabolic process GO:0016072 107 85 1,000 0,09408054 0,12887746 GO:0006364|rRNA processing, ! female pregnancy GO:0007565 130 87 1,000 0,09783727 0,13394389 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,09826871 0,13445451 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,09826871 0,13437457 ! negative regulation of defense response GO:0031348 19 17 0,000 0,09826871 0,13429473 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,09826871 0,13421498 ! glycerol metabolic process GO:0006071 20 17 0,000 0,09826871 0,13413533 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,09826871 0,13405577 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,09826871 0,13397631 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,09826871 0,13389694 ! signal complex assembly GO:0007172 29 17 0,000 0,09826871 0,13381766 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,09826871 0,13373848 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,09826871 0,13365939 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,09826871 0,1335804 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,09826871 0,13350149 ! memory GO:0007613 25 17 0,000 0,09826871 0,13342269 ! keratinization GO:0031424 17 17 0,000 0,09826871 0,13334397 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,09826871 0,13326535 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,09826871 0,13318682 ! retinoid metabolic process GO:0001523 22 17 0,000 0,09826871 0,13310838 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,09826871 0,13303004 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,09826871 0,13295178 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,09826871 0,13287362 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,09826871 0,13279555 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,09826871 0,13271757 ! membrane budding GO:0006900 29 17 0,000 0,09826871 0,13263969 ! heme metabolic process GO:0042168 27 17 0,000 0,09826871 0,13256189 ! actin filament bundle formation GO:0051017 26 17 0,000 0,09826871 0,13248419 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,09826871 0,13240658 ! body fluid secretion GO:0007589 27 17 0,000 0,09826871 0,13232906 ! stem cell differentiation GO:0048863 36 17 0,000 0,09826871 0,13225163 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,09826871 0,13217429 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,09826871 0,13209704 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,09826871 0,13201988 ! sensory perception of pain GO:0019233 23 17 0,000 0,09826871 0,13194281 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,09826871 0,13186583 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,09826871 0,13178894 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,09826871 0,13171214 ! synaptogenesis GO:0007416 24 17 0,000 0,09826871 0,13163543 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,09826871 0,13155881 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,09826871 0,13148227 ! cell-cell junction organization GO:0045216 25 17 0,000 0,09826871 0,13140583 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,09826871 0,13132948 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,09826871 0,13125321 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,09826871 0,13117703 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,09826871 0,13110095 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,09826871 0,13102494 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,0997315 0,13289829 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 1,000 0,0997315 0,13282134 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! hormone metabolic process GO:0042445 121 90 1,000 0,10355072 0,13782792 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,10374157 0,13800209 ! positive regulation of translation GO:0045727 28 18 0,000 0,10374157 0,13792232 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,10374157 0,13784264 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,10374157 0,13776305 ! cAMP metabolic process GO:0046058 33 18 0,000 0,10374157 0,13768356 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,10374157 0,13760416 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,10374157 0,13752485 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,10374157 0,13744563 ! axis specification GO:0009798 26 18 0,000 0,10374157 0,1373665 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,10374157 0,13728746 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,10374157 0,13720852 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,10374157 0,13712966 ! glutamine metabolic process GO:0006541 23 18 0,000 0,10374157 0,1370509 ! central nervous system neuron development GO:0021954 30 18 0,000 0,10374157 0,13697222 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,10374157 0,13689364 ! fucose metabolic process GO:0006004 26 18 0,000 0,10374157 0,13681514 ! response to fungus GO:0009620 19 18 0,000 0,10374157 0,13673674 ! peptide cross-linking GO:0018149 31 18 0,000 0,10374157 0,13665842 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,10374157 0,1365802 ! heart process GO:0003015 27 18 0,000 0,10374157 0,13650207 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,10374157 0,13642402 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,10374157 0,13634606 ! visual learning GO:0008542 35 18 0,000 0,10374157 0,1362682 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,10374157 0,13619042 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,10374157 0,13611273 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,10374157 0,13603513 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,10374157 0,13595761 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,10374157 0,13588019 ! vitamin transport GO:0051180 24 18 0,000 0,10374157 0,13580285 ! hormone transport GO:0009914 27 18 0,000 0,10374157 0,1357256 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,10374157 0,13564844 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,10374157 0,13557137 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,10374157 0,13549438 ! cell-cell recognition GO:0009988 20 18 0,000 0,10374157 0,13541749 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,10374157 0,13534067 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,10374157 0,13526395 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,10374157 0,13518731 ! RNA localization GO:0006403 135 91 1,000 0,10547532 0,13736877 ! response to virus GO:0009615 122 91 1,000 0,10547532 0,13729103 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,10740968 0,13972978 ! DNA recombination GO:0006310 146 92 1,000 0,10740968 0,13965079 ! sulfur metabolic process GO:0006790 118 92 1,000 0,10740968 0,1395719 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,10918153 0,14179419 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,10918153 0,14171417 ! positive regulation of ossification GO:0045778 30 19 0,000 0,10918153 0,14163424 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,10918153 0,1415544 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,10918153 0,14147465 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,10918153 0,14139499 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,10918153 0,14131542 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,10918153 0,14123594 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,10918153 0,14115655 ! sensory perception of taste GO:0050909 23 19 0,000 0,10918153 0,14107725 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,10918153 0,14099804 ! smooth muscle contraction GO:0006939 36 19 0,000 0,10918153 0,14091892 ! peroxisome organization GO:0007031 29 19 0,000 0,10918153 0,14083988 ! digestive system process GO:0022600 30 19 0,000 0,10918153 0,14076094 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,10918153 0,14068208 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,10918153 0,14060331 ! response to starvation GO:0042594 30 19 0,000 0,10918153 0,14052463 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,10918153 0,14044603 ! cytolysis GO:0019835 20 19 0,000 0,10918153 0,14036753 ! vasodilation GO:0042311 33 19 0,000 0,10918153 0,14028911 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,10918153 0,14021078 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,10918153 0,14013254 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,10918153 0,14005438 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,10918153 0,13997631 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,10918153 0,13989833 ! sarcomere organization GO:0045214 23 19 0,000 0,10918153 0,13982044 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,10918153 0,13974263 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,10918153 0,13966491 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,10918153 0,13958728 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,10918153 0,13950973 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,10918153 0,13943226 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,10918153 0,13935489 ! protein stabilization GO:0050821 26 19 0,000 0,10918153 0,1392776 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,10935359 0,13941977 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,10935359 0,13934253 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,11458877 0,14593255 ! iron ion transport GO:0006826 37 20 0,000 0,11458877 0,14585179 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,11458877 0,14577112 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,11458877 0,14569053 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,11458877 0,14561004 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,11458877 0,14552964 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,11458877 0,14544933 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,11458877 0,1453691 ! spinal cord development GO:0021510 31 20 0,000 0,11458877 0,14528896 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,11458877 0,14520891 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,11458877 0,14512895 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,11458877 0,14504908 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,11458877 0,14496929 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,11458877 0,1448896 ! collagen fibril organization GO:0030199 45 20 0,000 0,11458877 0,14480999 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,11458877 0,14473047 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,11458877 0,14465103 ! collagen catabolic process GO:0030574 25 20 0,000 0,11458877 0,14457168 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,11458877 0,14449242 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,11458877 0,14441325 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,11458877 0,14433416 ! alditol metabolic process GO:0019400 24 20 0,000 0,11458877 0,14425516 ! actin filament-based movement GO:0030048 34 20 0,000 0,11458877 0,14417625 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,11524087 0,14491744 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,11996351 0,15077381 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,11996351 0,15069146 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,11996351 0,15060921 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,11996351 0,15052704 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,11996351 0,15044496 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,11996351 0,15036298 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,11996351 0,15028108 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,11996351 0,15019927 ! phototransduction GO:0007602 25 21 0,000 0,11996351 0,15011755 ! visual behavior GO:0007632 39 21 0,000 0,11996351 0,15003592 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,11996351 0,14995438 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,11996351 0,14987293 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,11996351 0,14979157 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,11996351 0,14971029 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,11996351 0,1496291 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,11996351 0,149548 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,11996351 0,14946699 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,11996351 0,14938607 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,11996351 0,14930523 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,11996351 0,14922448 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,11996351 0,14914382 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,11996351 0,14906324 ! fatty acid transport GO:0015908 30 21 0,000 0,11996351 0,14898276 ! immunoglobulin production GO:0002377 33 21 0,000 0,11996351 0,14890235 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,11996351 0,14882204 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,11996351 0,14874181 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,11996351 0,14866167 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,11996351 0,14858162 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,11996351 0,14850165 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,11996351 0,14842177 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,11996351 0,14834197 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,11996351 0,14826226 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,11996351 0,14818263 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,11996351 0,14810309 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,11996351 0,14802364 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,11996351 0,14794427 ! protein import GO:0017038 156 99 1,000 0,12120767 0,14939852 ! protein localization in organelle GO:0033365 161 100 1,000 0,12321346 0,15178948 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,12530592 0,15428459 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,12530592 0,15420204 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,12530592 0,15411958 ! viral genome replication GO:0019079 29 22 0,000 0,12530592 0,15403721 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,12530592 0,15395492 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,12530592 0,15387272 ! leukocyte adhesion GO:0007159 38 22 0,000 0,12530592 0,15379062 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,12530592 0,15370859 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,12530592 0,15362666 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,12530592 0,15354481 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,12530592 0,15346305 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,12530592 0,15338138 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,12530592 0,15329979 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,12530592 0,1532183 ! lysosome organization GO:0007040 37 22 0,000 0,12530592 0,15313688 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,12530592 0,15305556 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,12530592 0,15297432 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,12530592 0,15289316 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,12530592 0,1528121 ! membrane depolarization GO:0051899 35 22 0,000 0,12530592 0,15273111 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,12530592 0,15265022 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,12530592 0,15256941 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,12530592 0,15248868 ! blastocyst development GO:0001824 37 22 0,000 0,12530592 0,15240804 ! neural tube closure GO:0001843 33 22 0,000 0,12530592 0,15232749 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,12530592 0,15224702 ! protein tetramerization GO:0051262 39 22 0,000 0,12530592 0,15216664 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,1306162 0,15853154 ! neuron fate commitment GO:0048663 32 23 0,000 0,1306162 0,15844793 ! embryonic pattern specification GO:0009880 31 23 0,000 0,1306162 0,1583644 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,1306162 0,15828096 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,1306162 0,15819761 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,1306162 0,15811435 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,1306162 0,15803118 ! vesicle targeting GO:0006903 32 23 0,000 0,1306162 0,15794809 ! osteoblast differentiation GO:0001649 40 23 0,000 0,1306162 0,15786509 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,1306162 0,15778218 ! interaction with host GO:0051701 37 23 0,000 0,1306162 0,15769935 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,1306162 0,15761661 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,1306162 0,15753396 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,1306162 0,1574514 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,1306162 0,15736892 ! cell fate determination GO:0001709 45 23 0,000 0,1306162 0,15728653 ! pentose metabolic process GO:0019321 31 23 0,000 0,1306162 0,15720422 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,1306162 0,157122 ! spermatid development GO:0007286 33 23 0,000 0,1306162 0,15703987 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,1306162 0,15695782 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,1306162 0,15687586 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,1306162 0,15679398 ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,1306162 0,15671219 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,1306162 0,15663048 ! regulation of amine transport GO:0051952 38 23 0,000 0,1306162 0,15654886 ! liver development GO:0001889 40 23 0,000 0,1306162 0,15646733 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,13589455 0,16270561 ! initiation of viral infection GO:0019059 42 24 0,000 0,13589455 0,16262095 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,13589455 0,16253639 ! superoxide metabolic process GO:0006801 32 24 0,000 0,13589455 0,16245191 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,13589455 0,16236752 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,13589455 0,16228321 ! sperm motility GO:0030317 27 24 0,000 0,13589455 0,162199 ! vacuole organization GO:0007033 39 24 0,000 0,13589455 0,16211487 ! receptor metabolic process GO:0043112 37 24 0,000 0,13589455 0,16203083 ! primary neural tube formation GO:0014020 35 24 0,000 0,13589455 0,16194688 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,13589455 0,16186301 ! base-excision repair GO:0006284 31 24 0,000 0,13589455 0,16177923 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,13589455 0,16169553 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,13589455 0,16161193 ! glutathione metabolic process GO:0006749 29 24 0,000 0,13589455 0,16152841 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,13589455 0,16144497 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,13589455 0,16136163 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,13589455 0,16127836 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,14114115 0,16741859 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,14114115 0,1673323 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,14114115 0,16724609 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,14114115 0,16715997 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,14114115 0,16707393 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,14114115 0,16698799 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,14114115 0,16690214 ! peptide transport GO:0015833 43 25 0,000 0,14114115 0,16681637 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,14114115 0,16673069 ! phospholipid transport GO:0015914 35 25 0,000 0,14114115 0,1666451 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,14114115 0,1665596 ! detection of light stimulus GO:0009583 30 25 0,000 0,14114115 0,16647418 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,1463562 0,17253678 ! translational initiation GO:0006413 43 26 0,000 0,1463562 0,17244839 ! regulation of pH GO:0006885 36 26 0,000 0,1463562 0,17236009 ! circadian rhythm GO:0007623 42 26 0,000 0,1463562 0,17227188 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,1463562 0,17218376 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,1463562 0,17209573 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,1463562 0,1720078 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,1463562 0,17191995 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,1463562 0,17183219 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,1463562 0,17174452 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,1463562 0,17165694 ! regulation of coagulation GO:0050818 39 26 0,000 0,1463562 0,17156945 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,15153987 0,17755563 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,15153987 0,17746523 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,15153987 0,17737492 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,15153987 0,1772847 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,15153987 0,17719457 ! catechol metabolic process GO:0009712 43 27 0,000 0,15153987 0,17710453 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,15153987 0,17701458 ! acute-phase response GO:0006953 42 27 0,000 0,15153987 0,17692473 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,15153987 0,17683496 ! myofibril assembly GO:0030239 36 27 0,000 0,15153987 0,17674529 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,15153987 0,17665571 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,15153987 0,17656622 ! natural killer cell activation GO:0030101 35 27 0,000 0,15153987 0,17647682 ! lipid oxidation GO:0034440 38 27 0,000 0,15153987 0,17638751 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,15153987 0,17629829 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,15153987 0,17620916 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,15153987 0,17612012 ! gene silencing GO:0016458 41 27 0,000 0,15153987 0,17603117 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,15669237 0,18192451 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,15669237 0,18183272 ! phenol metabolic process GO:0018958 44 28 0,000 0,15669237 0,18174102 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,15669237 0,18164942 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,15669237 0,18155791 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,15669237 0,18146649 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,15669237 0,18137516 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,15669237 0,18128393 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,15669237 0,18119278 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,15669237 0,18110173 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,15669237 0,18101077 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,15669237 0,1809199 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,15669237 0,18082912 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,15669237 0,18073844 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,15669237 0,18064784 ! mesoderm formation GO:0001707 46 28 0,000 0,15669237 0,18055734 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,15669237 0,18046692 ! BMP signaling pathway GO:0030509 40 28 0,000 0,15669237 0,1803766 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,15669237 0,18028637 ! neural tube formation GO:0001841 41 28 0,000 0,15669237 0,18019622 ! regulation of innate immune response GO:0045088 38 29 0,000 0,16181386 0,18599295 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,16181386 0,18590004 ! protein targeting to membrane GO:0006612 53 29 0,000 0,16181386 0,18580723 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,16181386 0,18571452 ! mismatch repair GO:0006298 34 29 0,000 0,16181386 0,18562189 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,16181386 0,18552936 ! muscle cell development GO:0055001 38 29 0,000 0,16181386 0,18543692 ! formation of primary germ layer GO:0001704 48 29 0,000 0,16181386 0,18534457 ! eye morphogenesis GO:0048592 51 29 0,000 0,16181386 0,18525231 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,16181386 0,18516014 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,16690455 0,19089034 ! organic anion transport GO:0015711 51 30 0,000 0,16690455 0,19079546 ! cholesterol transport GO:0030301 46 30 0,000 0,16690455 0,19070068 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,16690455 0,19060599 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,16690455 0,1905114 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,16690455 0,1904169 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,16690455 0,19032249 ! ceramide metabolic process GO:0006672 43 30 0,000 0,16690455 0,19022818 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,16690455 0,19013396 ! adult locomotory behavior GO:0008344 47 30 0,000 0,16690455 0,19003983 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,16690455 0,1899458 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,16690455 0,18985186 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,16690455 0,18975802 ! negative regulation of secretion GO:0051048 49 31 0,000 0,17196461 0,19541433 ! glial cell differentiation GO:0010001 55 31 0,000 0,17196461 0,19531783 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,17196461 0,19522142 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,17196461 0,19512511 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,17196461 0,19502889 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,17196461 0,19493277 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,17196461 0,19483675 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,17196461 0,19474082 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,17196461 0,19464498 ! cell fate specification GO:0001708 37 31 0,000 0,17196461 0,19454924 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,17196461 0,19445359 ! RNA modification GO:0009451 40 31 0,000 0,17196461 0,19435803 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,17699422 0,19994435 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,17699422 0,1998462 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,17699422 0,19974814 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,17699422 0,19965017 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,17699422 0,19955231 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,17699422 0,19945453 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,17699422 0,19935686 ! cytokine production GO:0001816 44 32 0,000 0,17699422 0,19925928 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,17699422 0,19916179 ! vesicle localization GO:0051648 47 32 0,000 0,17699422 0,1990644 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,18199357 0,2045871 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,18199357 0,20448715 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,18199357 0,20438731 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,18199357 0,20428756 ! ear morphogenesis GO:0042471 42 33 0,000 0,18199357 0,2041879 ! actomyosin structure organization GO:0031032 43 33 0,000 0,18199357 0,20408835 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,18199357 0,20398889 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,18199357 0,20388953 ! lipid homeostasis GO:0055088 55 33 0,000 0,18199357 0,20379026 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,18199357 0,2036911 ! regulation of proteolysis GO:0030162 50 33 0,000 0,18199357 0,20359202 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,18199357 0,20349305 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,18199357 0,20339417 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,18199357 0,20329539 ! mRNA catabolic process GO:0006402 48 34 0,000 0,18696283 0,20874491 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,18696283 0,20864362 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,18696283 0,20854244 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,18696283 0,20844135 ! feeding behavior GO:0007631 45 34 0,000 0,18696283 0,20834036 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,18696283 0,20823947 ! neuron migration GO:0001764 46 34 0,000 0,18696283 0,20813868 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,18696283 0,20803798 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,18696283 0,20793738 ! polyol metabolic process GO:0019751 44 34 0,000 0,18696283 0,20783688 ! aerobic respiration GO:0009060 47 34 0,000 0,18696283 0,20773648 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,18696283 0,20763617 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,19190219 0,21301884 ! Notch signaling pathway GO:0007219 56 35 0,000 0,19190219 0,21291608 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,19190219 0,21281342 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,19190219 0,21271086 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,19190219 0,2126084 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,19190219 0,21250604 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,19190219 0,21240377 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,19190219 0,2123016 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,19190219 0,21219954 ! protein homooligomerization GO:0051260 52 35 0,000 0,19190219 0,21209757 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,19681182 0,2174194 ! organic ether metabolic process GO:0018904 46 36 0,000 0,19681182 0,21731502 ! neural tube development GO:0021915 50 36 0,000 0,19681182 0,21721074 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,19681182 0,21710657 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,19681182 0,21700249 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,20169191 0,22227666 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,20169191 0,2221702 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,20169191 0,22206385 ! learning GO:0007612 67 37 0,000 0,20169191 0,2219576 ! ion transmembrane transport GO:0034220 56 37 0,000 0,20169191 0,22185145 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,20169191 0,2217454 ! regulation of protein secretion GO:0050708 51 37 0,000 0,20169191 0,22163946 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,20169191 0,22153361 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,20654262 0,22675323 ! gliogenesis GO:0042063 71 38 0,000 0,20654262 0,22664505 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,20654262 0,22653697 ! phagocytosis GO:0006909 60 38 0,000 0,20654262 0,22642899 ! maintenance of location in cell GO:0051651 69 38 0,000 0,20654262 0,22632111 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,21136413 0,23149405 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,21136413 0,23138387 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,21136413 0,23127379 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,21136413 0,23116381 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,21136413 0,23105395 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,21136413 0,23094418 ! JNK cascade GO:0007254 54 39 0,000 0,21136413 0,23083452 ! cell growth GO:0016049 61 39 0,000 0,21136413 0,23072497 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,21615662 0,23584451 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,21615662 0,23573268 ! regulation of tube size GO:0035150 60 40 0,000 0,21615662 0,23562096 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,21615662 0,23550935 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,21615662 0,23539784 ! peptide metabolic process GO:0006518 56 40 0,000 0,21615662 0,23528643 ! inner ear development GO:0048839 57 40 0,000 0,21615662 0,23517513 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,21615662 0,23506394 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,21615662 0,23495285 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,21615662 0,23484187 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,21615662 0,23473099 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,22092026 0,23979075 ! glucose transport GO:0015758 52 41 0,000 0,22092026 0,23967764 ! endosome transport GO:0016197 71 41 0,000 0,22092026 0,23956464 ! striated muscle contraction GO:0006941 62 41 0,000 0,22092026 0,23945174 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,22092026 0,23933895 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,22092026 0,23922627 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,22565522 0,24423859 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,22565522 0,24412371 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,22565522 0,24400894 ! hexose transport GO:0008645 54 42 0,000 0,22565522 0,24389427 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,22565522 0,24377971 ! excretion GO:0007588 63 42 0,000 0,22565522 0,24366526 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,22565522 0,24355092 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,22565522 0,24343668 ! neuromuscular process GO:0050905 79 43 0,000 0,23036167 0,24839749 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,23036167 0,24828109 ! tRNA processing GO:0008033 49 43 0,000 0,23036167 0,2481648 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,23036167 0,24804862 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,23503979 0,25296749 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,23503979 0,25284917 ! glycolysis GO:0006096 53 44 0,000 0,23503979 0,25273096 ! regulation of ion transport GO:0043269 57 44 0,000 0,23503979 0,25261286 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,23503979 0,25249487 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,23503979 0,25237699 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,23503979 0,25225922 ! RNA catabolic process GO:0006401 64 45 0,000 0,23968974 0,25712985 ! regulation of translational initiation GO:0006446 64 45 0,000 0,23968974 0,25700998 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,23968974 0,25689021 ! cell recognition GO:0008037 58 45 0,000 0,23968974 0,25677056 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,24431168 0,26160003 ! cell redox homeostasis GO:0045454 63 46 0,000 0,24431168 0,2614783 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,24431168 0,26135669 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,24431168 0,26123518 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,2489058 0,26602385 ! viral infectious cycle GO:0019058 71 47 0,000 0,2489058 0,2659003 ! endocrine system development GO:0035270 83 47 0,000 0,2489058 0,26577685 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,2489058 0,26565352 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,2489058 0,2655303 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,2489058 0,2654072 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,2489058 0,26528421 ! chloride transport GO:0006821 67 48 0,000 0,25347224 0,27002601 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,25347224 0,269901 ! gastrulation GO:0007369 73 48 0,000 0,25347224 0,2697761 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,25347224 0,26965132 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,25347224 0,26952666 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,25347224 0,26940211 ! regulation of endocytosis GO:0030100 63 48 0,000 0,25347224 0,26927767 ! nuclear export GO:0051168 69 48 0,000 0,25347224 0,26915335 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,25801119 0,27384667 ! sensory perception of smell GO:0007608 61 49 0,000 0,25801119 0,27372036 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,25801119 0,27359416 ! RNA elongation GO:0006354 62 49 0,000 0,25801119 0,27346808 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,25801119 0,27334211 ! maintenance of location GO:0051235 84 49 0,000 0,25801119 0,27321627 ! regulation of actin filament length GO:0030832 72 50 0,000 0,26252279 0,27786582 ! proton transport GO:0015992 75 50 0,000 0,26252279 0,27773801 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,26252279 0,27761031 ! hydrogen transport GO:0006818 77 51 0,000 0,26700722 0,28222271 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,26700722 0,28209307 ! adult behavior GO:0030534 80 51 0,000 0,26700722 0,28196355 ! transition metal ion transport GO:0000041 74 52 0,000 0,27146464 0,28653909 ! regulation of cellular component size GO:0032535 74 52 0,000 0,27146464 0,28640765 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,27146464 0,28627633 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,27146464 0,28614513 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,2758952 0,29068208 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,2758952 0,29054898 ! single fertilization GO:0007338 59 53 0,000 0,2758952 0,29041601 ! amino acid transport GO:0006865 84 54 0,000 0,28029908 0,29491669 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,28029908 0,29478184 ! glucose catabolic process GO:0006007 66 54 0,000 0,28029908 0,29464711 ! detection of external stimulus GO:0009581 66 54 0,000 0,28029908 0,29451251 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,28467642 0,29897523 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,28467642 0,29883878 ! carbohydrate transport GO:0008643 74 57 0,000 0,29335214 0,30780562 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,29335214 0,30766526 ! viral reproductive process GO:0022415 87 58 0,000 0,29765083 0,3120314 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,29765083 0,31188925 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,29765083 0,31174722 ! activation of MAPK activity GO:0000187 84 59 0,000 0,30192361 0,31607843 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,30192361 0,31593463 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,30617065 0,32023306 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,30617065 0,32008749 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,30617065 0,31994207 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,30617065 0,31979677 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,30617065 0,31965161 ! fertilization GO:0009566 68 60 0,000 0,30617065 0,31950657 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,31039209 0,32376499 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,31039209 0,32361822 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,31039209 0,32347159 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,31039209 0,32332509 ! neurotransmitter transport GO:0006836 81 62 0,000 0,31458808 0,32754757 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,31458808 0,32739936 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,31458808 0,32725128 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,31458808 0,32710334 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,31875879 0,3312902 ! viral reproduction GO:0016032 92 63 0,000 0,31875879 0,33114056 ! appendage morphogenesis GO:0035107 93 64 0,000 0,32290435 0,33529571 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,32290435 0,33514441 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,32290435 0,33499324 ! hexose catabolic process GO:0019320 82 64 0,000 0,32290435 0,3348422 ! appendage development GO:0048736 94 65 0,000 0,32702492 0,33896229 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,32702492 0,3388096 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,32702492 0,33865706 ! defense response to bacterium GO:0042742 73 65 0,000 0,32702492 0,33850464 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,32702492 0,33835237 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,32702492 0,33820023 ! activation of immune response GO:0002253 83 65 0,000 0,32702492 0,33804823 ! protein oligomerization GO:0051259 100 65 0,000 0,32702492 0,33789637 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,33112065 0,34197463 ! antigen processing and presentation GO:0019882 96 66 0,000 0,33112065 0,34182114 ! regulation of immune effector process GO:0002697 101 66 0,000 0,33112065 0,34166779 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,33519169 0,3457134 ! acute inflammatory response GO:0002526 92 68 0,000 0,33923819 0,34973009 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,33923819 0,3495734 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,33923819 0,34941685 ! inorganic anion transport GO:0015698 93 68 0,000 0,33923819 0,34926044 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,34326028 0,35324324 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,34326028 0,35308526 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,34326028 0,35292742 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,34725812 0,35687832 ! amine transport GO:0015837 101 70 0,000 0,34725812 0,35671893 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,34725812 0,35655968 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,35123185 0,36047892 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,35123185 0,36031814 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,35123185 0,3601575 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,35518162 0,36404534 ! regulation of blood pressure GO:0008217 107 73 0,000 0,35910757 0,36790531 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,35910757 0,3677415 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,36300984 0,37157215 ! blood coagulation GO:0007596 116 75 0,000 0,36688857 0,37537532 GO:0050817|coagulation, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,37457598 0,38307015 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,37457598 0,38289989 ! protein ubiquitination GO:0016567 125 77 0,000 0,37457598 0,38272979 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,37457598 0,38255984 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,37838494 0,38627846 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,38217092 0,38997033 ! cellular respiration GO:0045333 107 79 0,000 0,38217092 0,38979739 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,38217092 0,38962461 ! regulation of lyase activity GO:0051339 133 79 0,000 0,38217092 0,38945198 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,38217092 0,38927951 ! chromatin assembly GO:0031497 102 80 0,000 0,38593406 0,39293862 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,38593406 0,39276475 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,38593406 0,39259104 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,38593406 0,39241748 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,38967449 0,39604566 ! hemostasis GO:0007599 125 81 0,000 0,38967449 0,39587073 ! regulation of neurological system process GO:0031644 122 81 0,000 0,38967449 0,39569595 ! vitamin metabolic process GO:0006766 103 81 0,000 0,38967449 0,39552133 ! detection of stimulus GO:0051606 108 82 0,000 0,39339235 0,39911884 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,39708778 0,40269043 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,39708778 0,40251295 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,4007609 0,4060573 ! sterol metabolic process GO:0016125 120 84 0,000 0,4007609 0,4058785 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,40441186 0,40939581 ! transcription initiation GO:0006352 118 85 0,000 0,40441186 0,4092157 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,40804078 0,41270616 ! nucleosome organization GO:0034728 114 87 0,000 0,4116478 0,4161714 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,4116478 0,41598855 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,4116478 0,41580586 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,41523304 0,4192432 ! protein processing GO:0016485 114 88 0,000 0,41523304 0,41905924 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,41879665 0,4224703 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,41879665 0,42228509 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,42233874 0,42567007 ! ATP metabolic process GO:0046034 137 91 0,000 0,42585944 0,42903054 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,42935889 0,43236666 ! positive regulation of immune response GO:0050778 121 92 0,000 0,42935889 0,43217744 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,43283721 0,435488 ! electron transport chain GO:0022900 123 94 0,000 0,43629452 0,43877455 ! carboxylic acid transport GO:0046942 147 95 0,000 0,43973096 0,44203724 GO:0015849|organic acid transport, ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,44314664 0,44527623 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,44314664 0,44508178 ! protein maturation GO:0051604 129 96 0,000 0,44314664 0,44488751 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,4465417 0,44810031 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,4465417 0,44790489 ! calcium ion transport GO:0006816 167 99 0,000 0,45327042 0,45445596 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,45660433 0,45759911 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,45660433 0,45739981 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,45660433 0,45720068 ! divalent metal ion transport GO:0070838 171 100 0,000 0,45660433 0,45700172 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,45660433 0,45680294 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,45660433 0,45660433