pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6448-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 115 46 8,000 8,463E-13 2,036E-09 ! interphase of mitotic cell cycle GO:0051329 209 95 9,000 2,83E-11 3,404E-08 ! interphase GO:0051325 213 98 9,000 3,875E-11 3,108E-08 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 6,000 9,691E-09 5,829E-06 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 3,000 3,267E-08 1,572E-05 ! induction of positive chemotaxis GO:0050930 15 9 3,000 5,86E-08 2,35E-05 ! negative regulation of phosphorylation GO:0042326 47 24 4,000 8,585E-08 2,951E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 3,000 9,731E-08 2,926E-05 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 4,000 1,319E-07 3,525E-05 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of positive chemotaxis GO:0050926 19 12 3,000 2,277E-07 5,478E-05 GO:0050927|positive regulation of positive chemotaxis, ! regulation of hormone metabolic process GO:0032350 26 12 3,000 2,277E-07 4,98E-05 ! positive regulation of cell migration GO:0030335 126 57 5,000 2,941E-07 5,898E-05 ! positive regulation of cell motion GO:0051272 146 64 5,000 5,915E-07 1,095E-04 ! negative regulation of protein kinase activity GO:0006469 130 67 5,000 7,782E-07 1,337E-04 ! negative regulation of kinase activity GO:0033673 131 68 5,000 8,503E-07 1,364E-04 ! carbohydrate homeostasis GO:0033500 53 38 4,000 9,614E-07 1,446E-04 GO:0042593|glucose homeostasis, ! negative regulation of transferase activity GO:0051348 140 72 5,000 1,195E-06 1,691E-04 ! myoblast cell fate commitment GO:0048625 16 6 2,000 2,031E-06 2,715E-04 ! neural nucleus development GO:0048857 14 6 2,000 2,031E-06 2,572E-04 ! male sex differentiation GO:0046661 76 44 4,000 2,033E-06 2,446E-04 ! positive regulation of phosphorylation GO:0042327 129 79 5,000 2,069E-06 2,371E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 2,164E-06 2,367E-04 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 5,000 2,398E-06 2,508E-04 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of locomotion GO:0040017 39 21 3,000 2,664E-06 2,67E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! negative regulation of growth GO:0045926 155 84 5,000 2,968E-06 2,857E-04 ! positive regulation of cell cycle GO:0045787 89 48 4,000 3,158E-06 2,922E-04 ! regulation of chemotaxis GO:0050920 40 22 3,000 3,244E-06 2,89E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 2,000 3,542E-06 3,044E-04 ! regulation of behavior GO:0050795 43 24 3,000 4,677E-06 3,881E-04 ! response to UV GO:0009411 104 53 4,000 5,193E-06 4,165E-04 ! positive regulation of insulin secretion GO:0032024 15 8 2,000 5,648E-06 4,384E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 5,648E-06 4,247E-04 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 5,648E-06 4,118E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 5,648E-06 3,997E-04 ! fat cell differentiation GO:0045444 50 27 3,000 7,641E-06 5,252E-04 ! cell cycle arrest GO:0007050 213 100 5,000 8,184E-06 5,469E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 1,202E-05 7,816E-04 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 1,202E-05 7,61E-04 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 2,000 1,202E-05 7,415E-04 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 1,202E-05 7,23E-04 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 2,000 1,647E-05 9,665E-04 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 2,000 1,647E-05 9,435E-04 ! chondrocyte differentiation GO:0002062 24 11 2,000 1,647E-05 9,215E-04 ! positive regulation of peptide secretion GO:0002793 22 11 2,000 1,647E-05 9,006E-04 ! negative regulation of glucose import GO:0046325 17 11 2,000 1,647E-05 8,806E-04 GO:0010829|negative regulation of glucose transport, ! negative regulation of cell growth GO:0030308 132 67 4,000 1,658E-05 8,67E-04 ! lung development GO:0030324 144 67 4,000 1,658E-05 8,485E-04 ! positive regulation of gene-specific transcription GO:0043193 65 33 3,000 1,743E-05 8,736E-04 ! negative regulation of cell size GO:0045792 134 69 4,000 1,914E-05 9,4E-04 ! urogenital system development GO:0001655 137 69 4,000 1,914E-05 9,212E-04 ! respiratory tube development GO:0030323 150 70 4,000 2,054E-05 9,689E-04 ! regulation of B cell proliferation GO:0030888 20 12 2,000 2,188E-05 1,013E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 2,188E-05 9,934E-04 GO:0042130|negative regulation of T cell proliferation, ! reproductive structure development GO:0048608 113 71 4,000 2,201E-05 9,807E-04 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 4,000 2,356E-05 1,031E-03 ! respiratory system development GO:0060541 153 72 4,000 2,356E-05 1,012E-03 ! regulation of monooxygenase activity GO:0032768 33 13 2,000 2,835E-05 1,197E-03 ! development of primary sexual characteristics GO:0045137 124 76 4,000 3,065E-05 1,271E-03 ! development of primary male sexual characteristics GO:0046546 66 39 3,000 3,427E-05 1,398E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 2,000 3,596E-05 1,442E-03 ! release of cytochrome c from mitochondria GO:0001836 30 14 2,000 3,596E-05 1,418E-03 ! response to hypoxia GO:0001666 171 81 4,000 4,171E-05 1,619E-03 ! negative regulation of bone remodeling GO:0046851 33 15 2,000 4,479E-05 1,711E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 4,479E-05 1,684E-03 ! response to oxygen levels GO:0070482 176 83 4,000 4,691E-05 1,736E-03 ! epithelial cell differentiation GO:0030855 79 43 3,000 5,067E-05 1,847E-03 ! positive regulation of response to external stimulus GO:0032103 77 43 3,000 5,067E-05 1,82E-03 ! negative regulation of tissue remodeling GO:0034104 36 16 2,000 5,494E-05 1,944E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 5,494E-05 1,916E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! induction of apoptosis by intracellular signals GO:0008629 93 45 3,000 6,073E-05 2,087E-03 ! positive regulation of protein modification process GO:0031401 136 88 4,000 6,211E-05 2,105E-03 ! regulation of gene-specific transcription GO:0032583 96 46 3,000 6,628E-05 2,215E-03 ! negative regulation of cell migration GO:0030336 115 46 3,000 6,628E-05 2,184E-03 ! pigmentation GO:0043473 100 46 3,000 6,628E-05 2,155E-03 ! regulation of viral genome replication GO:0045069 28 17 2,000 6,648E-05 2,133E-03 ! myoblast differentiation GO:0045445 45 17 2,000 6,648E-05 2,105E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 2,000 6,648E-05 2,077E-03 ! neutrophil chemotaxis GO:0030593 27 17 2,000 6,648E-05 2,051E-03 ! negative regulation of homeostatic process GO:0032845 33 17 2,000 6,648E-05 2,025E-03 ! regulation of cell cycle process GO:0010564 149 90 4,000 6,916E-05 2,08E-03 ! sex differentiation GO:0007548 145 90 4,000 6,916E-05 2,054E-03 ! regulation of mast cell proliferation GO:0070666 81 48 3,000 7,845E-05 2,302E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 7,95E-05 2,305E-03 ! positive regulation of hormone secretion GO:0046887 32 19 2,000 9,408E-05 2,695E-03 ! pigmentation during development GO:0048066 41 19 2,000 9,408E-05 2,663E-03 ! G1 phase GO:0051318 40 19 2,000 9,408E-05 2,632E-03 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 2,000 9,408E-05 2,602E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 3,000 9,966E-05 2,725E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of angiogenesis GO:0045765 114 52 3,000 1,076E-04 2,908E-03 ! cartilage development GO:0051216 90 52 3,000 1,076E-04 2,876E-03 ! skeletal muscle tissue development GO:0007519 186 99 4,000 1,088E-04 2,876E-03 GO:0060538|skeletal muscle organ development, ! pancreas development GO:0031016 35 20 2,000 1,103E-04 2,885E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 1,103E-04 2,854E-03 ! regulation of glucose import GO:0046324 29 20 2,000 1,103E-04 2,823E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 40 20 2,000 1,103E-04 2,794E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 1,282E-04 3,214E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 1,282E-04 3,181E-03 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 1,282E-04 3,148E-03 ! negative regulation of cell motion GO:0051271 134 55 3,000 1,34E-04 3,257E-03 ! skeletal muscle fiber development GO:0048741 111 56 3,000 1,438E-04 3,46E-03 ! regulation of DNA replication GO:0006275 101 56 3,000 1,438E-04 3,426E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 1,48E-04 3,491E-03 ! apoptotic nuclear changes GO:0030262 32 22 2,000 1,48E-04 3,457E-03 ! muscle fiber development GO:0048747 112 57 3,000 1,541E-04 3,565E-03 ! gluconeogenesis GO:0006094 33 23 2,000 1,696E-04 3,886E-03 ! regulation of cell-matrix adhesion GO:0001952 78 23 2,000 1,696E-04 3,849E-03 GO:0010810|regulation of cell-substrate adhesion, ! sex determination GO:0007530 47 23 2,000 1,696E-04 3,813E-03 ! regulation of viral reproduction GO:0050792 38 23 2,000 1,696E-04 3,778E-03 ! protein amino acid autophosphorylation GO:0046777 141 60 3,000 1,882E-04 4,154E-03 ! positive regulation of fibroblast proliferation GO:0048146 43 24 2,000 1,931E-04 4,225E-03 ! regulation of oxidoreductase activity GO:0051341 46 24 2,000 1,931E-04 4,187E-03 ! gonad development GO:0008406 98 62 3,000 2,137E-04 4,591E-03 ! regulation of homeostatic process GO:0032844 134 62 3,000 2,137E-04 4,55E-03 ! hemoglobin biosynthetic process GO:0042541 7 5 1,000 2,187E-04 4,616E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,187E-04 4,576E-03 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 1,000 2,187E-04 4,536E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 2,187E-04 4,497E-03 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 2,187E-04 4,459E-03 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 1,000 2,187E-04 4,422E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 2,187E-04 4,385E-03 ! regulation of retroviral genome replication GO:0045091 7 5 1,000 2,187E-04 4,349E-03 ! histidine catabolic process GO:0006548 6 5 1,000 2,187E-04 4,313E-03 GO:0009077|histidine family amino acid catabolic process, ! microvillus organization GO:0032528 7 5 1,000 2,187E-04 4,278E-03 GO:0030033|microvillus assembly, ! mRNA transcription GO:0009299 9 5 1,000 2,187E-04 4,244E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 2,187E-04 4,21E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 2,187E-04 4,176E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 2,187E-04 4,143E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 2,187E-04 4,111E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 2,187E-04 4,079E-03 ! mitotic recombination GO:0006312 9 5 1,000 2,187E-04 4,048E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 2,187E-04 4,017E-03 ! B cell homeostasis GO:0001782 13 5 1,000 2,187E-04 3,986E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 2,187E-04 3,956E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,187E-04 3,927E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 2,187E-04 3,898E-03 ! stem cell division GO:0017145 11 5 1,000 2,187E-04 3,869E-03 GO:0048103|somatic stem cell division, ! G2/M transition of mitotic cell cycle GO:0000086 43 25 2,000 2,187E-04 3,841E-03 ! vasculogenesis GO:0001570 46 25 2,000 2,187E-04 3,814E-03 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 2,187E-04 3,786E-03 ! regulation of insulin secretion GO:0050796 37 25 2,000 2,187E-04 3,759E-03 ! regulation of mitosis GO:0007088 105 63 3,000 2,274E-04 3,88E-03 GO:0051783|regulation of nuclear division, ! pyruvate metabolic process GO:0006090 38 26 2,000 2,464E-04 4,175E-03 ! regulation of endothelial cell proliferation GO:0001936 57 26 2,000 2,464E-04 4,146E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 2,000 2,464E-04 4,117E-03 ! cellular response to oxidative stress GO:0034599 39 26 2,000 2,464E-04 4,089E-03 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 2,763E-04 4,553E-03 ! male gonad development GO:0008584 44 27 2,000 2,763E-04 4,522E-03 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 2,763E-04 4,491E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 3,000 2,883E-04 4,656E-03 ! negative regulation of protein modification process GO:0031400 60 28 2,000 3,083E-04 4,946E-03 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 3,083E-04 4,913E-03 ! peptidyl-tyrosine modification GO:0018212 50 28 2,000 3,083E-04 4,881E-03 ! cell cycle checkpoint GO:0000075 137 69 3,000 3,228E-04 5,077E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 3,27E-04 5,109E-03 ! embryonic hemopoiesis GO:0035162 14 6 1,000 3,27E-04 5,076E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 3,27E-04 5,044E-03 ! establishment of spindle localization GO:0051293 12 6 1,000 3,27E-04 5,012E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 3,27E-04 4,98E-03 GO:0045686|negative regulation of glial cell differentiation, ! enucleate erythrocyte differentiation GO:0043353 12 6 1,000 3,27E-04 4,949E-03 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 3,27E-04 4,918E-03 ! negative regulation of B cell activation GO:0050869 13 6 1,000 3,27E-04 4,887E-03 ! regulation of peptide secretion GO:0002791 47 29 2,000 3,427E-04 5,09E-03 ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 3,795E-04 5,602E-03 ! regulation of B cell activation GO:0050864 50 30 2,000 3,795E-04 5,568E-03 ! negative regulation of transcription regulator activity GO:0090048 58 31 2,000 4,187E-04 6,106E-03 GO:0043433|negative regulation of transcription factor activity, ! regulation of transcription factor activity GO:0051090 126 74 3,000 4,22E-04 6,116E-03 GO:0090046|regulation of transcription regulator activity, ! prostate gland development GO:0030850 13 7 1,000 4,564E-04 6,576E-03 ! regulation of lipid kinase activity GO:0043550 13 7 1,000 4,564E-04 6,537E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 4,564E-04 6,498E-03 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 4,564E-04 6,46E-03 ! mRNA stabilization GO:0048255 18 7 1,000 4,564E-04 6,422E-03 GO:0043489|RNA stabilization, ! organ growth GO:0035265 15 7 1,000 4,564E-04 6,385E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 4,564E-04 6,348E-03 ! cranial nerve morphogenesis GO:0021602 11 7 1,000 4,564E-04 6,311E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 4,564E-04 6,275E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 4,564E-04 6,24E-03 ! oxygen homeostasis GO:0032364 12 7 1,000 4,564E-04 6,204E-03 ! peptidyl-threonine modification GO:0018210 25 7 1,000 4,564E-04 6,17E-03 ! regulation of epidermal cell differentiation GO:0045604 8 7 1,000 4,564E-04 6,135E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 4,564E-04 6,101E-03 ! metanephros development GO:0001656 74 32 2,000 4,604E-04 6,121E-03 ! hexose biosynthetic process GO:0019319 48 32 2,000 4,604E-04 6,087E-03 ! negative regulation of MAP kinase activity GO:0043407 69 32 2,000 4,604E-04 6,054E-03 ! hindbrain development GO:0030902 61 32 2,000 4,604E-04 6,021E-03 ! leukocyte chemotaxis GO:0030595 50 33 2,000 5,047E-04 6,564E-03 GO:0060326|cell chemotaxis, ! response to metal ion GO:0010038 140 80 3,000 5,675E-04 7,34E-03 ! muscle cell differentiation GO:0042692 159 80 3,000 5,675E-04 7,301E-03 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 2,000 6,013E-04 7,696E-03 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 6,067E-04 7,723E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 6,067E-04 7,683E-03 ! hemoglobin metabolic process GO:0020027 13 8 1,000 6,067E-04 7,643E-03 ! pigment granule organization GO:0048753 16 8 1,000 6,067E-04 7,603E-03 ! histidine metabolic process GO:0006547 16 8 1,000 6,067E-04 7,563E-03 GO:0009075|histidine family amino acid metabolic process, ! ER overload response GO:0006983 12 8 1,000 6,067E-04 7,524E-03 ! regulation of pigmentation during development GO:0048070 24 8 1,000 6,067E-04 7,486E-03 ! melanin metabolic process GO:0006582 15 8 1,000 6,067E-04 7,448E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 6,067E-04 7,41E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 6,067E-04 7,372E-03 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 6,067E-04 7,335E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 6,067E-04 7,299E-03 ! response to UV-B GO:0010224 16 8 1,000 6,067E-04 7,262E-03 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 1,000 6,067E-04 7,226E-03 ! DNA topological change GO:0006265 12 8 1,000 6,067E-04 7,191E-03 ! mast cell activation GO:0045576 14 8 1,000 6,067E-04 7,156E-03 ! androgen receptor signaling pathway GO:0030521 74 36 2,000 6,537E-04 7,673E-03 ! monosaccharide biosynthetic process GO:0046364 52 36 2,000 6,537E-04 7,635E-03 ! negative regulation of cell activation GO:0050866 65 36 2,000 6,537E-04 7,599E-03 ! tissue remodeling GO:0048771 76 37 2,000 7,09E-04 8,201E-03 ! negative regulation of DNA binding GO:0043392 68 37 2,000 7,09E-04 8,162E-03 ! regulation of protein stability GO:0031647 73 37 2,000 7,09E-04 8,123E-03 ! response to inorganic substance GO:0010035 153 86 3,000 7,455E-04 8,501E-03 ! mitochondrion organization GO:0007005 148 86 3,000 7,455E-04 8,461E-03 ! nucleus organization GO:0006997 67 38 2,000 7,671E-04 8,665E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 7,776E-04 8,743E-03 ! regulation of glycolysis GO:0006110 21 9 1,000 7,776E-04 8,702E-03 ! microtubule bundle formation GO:0001578 21 9 1,000 7,776E-04 8,662E-03 ! T cell selection GO:0045058 23 9 1,000 7,776E-04 8,622E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 1,000 7,776E-04 8,583E-03 ! behavioral fear response GO:0001662 22 9 1,000 7,776E-04 8,543E-03 GO:0002209|behavioral defense response, ! motor axon guidance GO:0008045 16 9 1,000 7,776E-04 8,504E-03 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 7,776E-04 8,466E-03 ! gas homeostasis GO:0033483 16 9 1,000 7,776E-04 8,428E-03 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 7,776E-04 8,39E-03 ! positive regulation of erythrocyte differentiation GO:0045648 29 9 1,000 7,776E-04 8,353E-03 ! regulation of macrophage differentiation GO:0045649 15 9 1,000 7,776E-04 8,315E-03 ! regulation of DNA binding GO:0051101 155 88 3,000 8,127E-04 8,652E-03 ! gland development GO:0048732 206 88 3,000 8,127E-04 8,614E-03 ! regulation of cell adhesion GO:0030155 212 89 3,000 8,479E-04 8,947E-03 ! regulation of hormone secretion GO:0046883 62 40 2,000 8,922E-04 9,374E-03 ! negative regulation of binding GO:0051100 72 40 2,000 8,922E-04 9,334E-03 ! mesenchymal cell development GO:0014031 87 40 2,000 8,922E-04 9,293E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of T cell proliferation GO:0042129 71 41 2,000 9,594E-04 9,949E-03 ! T cell differentiation GO:0030217 81 41 2,000 9,594E-04 9,907E-03 ! regulation of T cell differentiation GO:0045580 70 41 2,000 9,594E-04 9,864E-03 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 9,69E-04 9,921E-03 ! lung alveolus development GO:0048286 26 10 1,000 9,69E-04 9,879E-03 ! B cell proliferation GO:0042100 18 10 1,000 9,69E-04 9,838E-03 ! epithelial cell development GO:0002064 20 10 1,000 9,69E-04 9,796E-03 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 1,000 9,69E-04 9,755E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 9,69E-04 9,715E-03 ! regulation of gliogenesis GO:0014013 23 10 1,000 9,69E-04 9,674E-03 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell activation GO:0046631 23 10 1,000 9,69E-04 9,634E-03 ! response to dsRNA GO:0043331 20 10 1,000 9,69E-04 9,595E-03 ! DNA ligation GO:0006266 19 10 1,000 9,69E-04 9,555E-03 ! positive regulation of leukocyte migration GO:0002687 25 10 1,000 9,69E-04 9,516E-03 ! methionine biosynthetic process GO:0009086 19 10 1,000 9,69E-04 9,478E-03 ! positive regulation of viral reproduction GO:0048524 18 10 1,000 9,69E-04 9,439E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 9,69E-04 9,401E-03 GO:0043470|regulation of carbohydrate catabolic process, ! oocyte development GO:0048599 17 10 1,000 9,69E-04 9,363E-03 ! response to nicotine GO:0035094 20 10 1,000 9,69E-04 9,326E-03 ! localization within membrane GO:0051668 20 10 1,000 9,69E-04 9,289E-03 ! positive regulation of MAP kinase activity GO:0043406 160 93 3,000 9,993E-04 9,541E-03 ! response to reactive oxygen species GO:0000302 67 42 2,000 1,03E-03 9,792E-03 ! alcohol biosynthetic process GO:0046165 59 42 2,000 1,03E-03 9,753E-03 ! regulation of myeloid cell differentiation GO:0045637 98 42 2,000 1,03E-03 9,715E-03 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 1,103E-03 0,01036696 ! regulation of DNA metabolic process GO:0051052 178 97 3,000 1,169E-03 0,01094151 ! blood vessel remodeling GO:0001974 29 11 1,000 1,181E-03 0,01101088 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 1,000 1,181E-03 0,01096837 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 1,181E-03 0,01092618 ! melanocyte differentiation GO:0030318 21 11 1,000 1,181E-03 0,01088432 GO:0050931|pigment cell differentiation, ! negative regulation of ossification GO:0030279 26 11 1,000 1,181E-03 0,01084278 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 1,000 1,181E-03 0,01080155 ! DNA methylation GO:0006306 19 11 1,000 1,181E-03 0,01076064 GO:0006305|DNA alkylation, ! neuroblast proliferation GO:0007405 24 11 1,000 1,181E-03 0,01072003 ! regulation of leukocyte migration GO:0002685 26 11 1,000 1,181E-03 0,01067973 ! oocyte differentiation GO:0009994 18 11 1,000 1,181E-03 0,01063973 ! thymus development GO:0048538 27 11 1,000 1,181E-03 0,01060003 ! leukocyte migration GO:0050900 68 45 2,000 1,26E-03 0,01126638 ! branching morphogenesis of a tube GO:0048754 97 45 2,000 1,26E-03 0,01122465 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 1,412E-03 0,01254037 ! folic acid and derivative biosynthetic process GO:0009396 21 12 1,000 1,412E-03 0,01249426 ! hippocampus development GO:0021766 26 12 1,000 1,412E-03 0,01244849 ! focal adhesion formation GO:0048041 35 12 1,000 1,412E-03 0,01240306 ! fear response GO:0042596 26 12 1,000 1,412E-03 0,01235796 ! cranial nerve development GO:0021545 20 12 1,000 1,412E-03 0,01231318 ! histone acetylation GO:0016573 26 12 1,000 1,412E-03 0,01226873 ! mRNA polyadenylation GO:0006378 23 12 1,000 1,412E-03 0,0122246 ! autonomic nervous system development GO:0048483 24 12 1,000 1,412E-03 0,01218078 ! gland morphogenesis GO:0022612 29 12 1,000 1,412E-03 0,01213728 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,412E-03 0,01209409 ! T cell homeostasis GO:0043029 25 12 1,000 1,412E-03 0,0120512 ! spleen development GO:0048536 22 12 1,000 1,412E-03 0,01200862 ! digestive tract morphogenesis GO:0048546 26 12 1,000 1,412E-03 0,01196633 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 1,412E-03 0,01192435 ! positive regulation of defense response GO:0031349 76 47 2,000 1,43E-03 0,01202597 ! cellular component disassembly GO:0022411 86 48 2,000 1,52E-03 0,01273916 ! activation of caspase activity GO:0006919 84 48 2,000 1,52E-03 0,01269492 ! regulation of inflammatory response GO:0050727 75 48 2,000 1,52E-03 0,012651 ! regulation of lymphocyte differentiation GO:0045619 81 48 2,000 1,52E-03 0,01260737 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 1,613E-03 0,01333755 ! regulation of chemokine production GO:0032642 18 13 1,000 1,664E-03 0,01371211 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 1,664E-03 0,01366531 ! methionine metabolic process GO:0006555 27 13 1,000 1,664E-03 0,01361883 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 1,664E-03 0,01357266 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 1,664E-03 0,01352681 ! regulation of epidermis development GO:0045682 19 13 1,000 1,664E-03 0,01348126 ! regulation of mRNA stability GO:0043488 31 13 1,000 1,664E-03 0,01343602 ! mRNA 3'-end processing GO:0031124 24 13 1,000 1,664E-03 0,01339109 ! embryonic placenta development GO:0001892 23 13 1,000 1,664E-03 0,01334645 ! negative regulation of immune system process GO:0002683 95 50 2,000 1,71E-03 0,01367046 ! response to estrogen stimulus GO:0043627 93 51 2,000 1,811E-03 0,01442715 ! chromatin remodeling GO:0006338 109 51 2,000 1,811E-03 0,01437953 ! regulation of muscle contraction GO:0006937 81 52 2,000 1,915E-03 0,01515759 ! morphogenesis of a branching structure GO:0001763 111 52 2,000 1,915E-03 0,01510789 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 1,936E-03 0,01521843 ! hair follicle morphogenesis GO:0031069 26 14 1,000 1,936E-03 0,01516885 ! RNA polyadenylation GO:0043631 30 14 1,000 1,936E-03 0,0151196 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 1,936E-03 0,01507067 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 31 14 1,000 1,936E-03 0,01502206 ! response to gamma radiation GO:0010332 28 14 1,000 1,936E-03 0,01497376 ! regulation of erythrocyte differentiation GO:0045646 44 14 1,000 1,936E-03 0,01492576 ! male genitalia development GO:0030539 24 14 1,000 1,936E-03 0,01487808 ! regulation of RNA stability GO:0043487 32 14 1,000 1,936E-03 0,01483069 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 2,226E-03 0,01700538 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 2,226E-03 0,01695157 ! muscle maintenance GO:0046716 26 15 1,000 2,226E-03 0,01689809 ! lymphocyte homeostasis GO:0002260 30 15 1,000 2,226E-03 0,01684495 ! epithelial to mesenchymal transition GO:0001837 28 15 1,000 2,226E-03 0,01679215 ! positive regulation of caspase activity GO:0043280 95 55 2,000 2,25E-03 0,01691889 GO:0010952|positive regulation of peptidase activity, ! aging GO:0007568 103 55 2,000 2,25E-03 0,01686619 ! regulation of bone remodeling GO:0046850 137 57 2,000 2,493E-03 0,01862432 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 2,537E-03 0,0188949 ! G1 phase of mitotic cell cycle GO:0000080 35 16 1,000 2,537E-03 0,01883659 ! sulfur amino acid biosynthetic process GO:0000097 28 16 1,000 2,537E-03 0,01877863 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 2,537E-03 0,01872102 GO:0031114|regulation of microtubule depolymerization, ! aspartate family amino acid biosynthetic process GO:0009067 27 16 1,000 2,537E-03 0,01866377 ! defense response to virus GO:0051607 37 16 1,000 2,537E-03 0,01860687 ! regulation of tissue remodeling GO:0034103 140 58 2,000 2,619E-03 0,01915653 ! positive regulation of secretion GO:0051047 95 59 2,000 2,75E-03 0,02005276 ! metencephalon development GO:0022037 30 17 1,000 2,866E-03 0,02083223 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 2,866E-03 0,02076948 ! limbic system development GO:0021761 36 17 1,000 2,866E-03 0,02070711 ! heart looping GO:0001947 30 17 1,000 2,866E-03 0,02064511 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 2,866E-03 0,02058348 ! regulation of protein binding GO:0043393 33 17 1,000 2,866E-03 0,02052222 ! genitalia development GO:0048806 30 17 1,000 2,866E-03 0,02046133 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 1,000 2,866E-03 0,02040079 ! neural crest cell migration GO:0001755 37 17 1,000 2,866E-03 0,02034061 ! folic acid and derivative metabolic process GO:0006760 33 17 1,000 2,866E-03 0,02028079 ! RNA 3'-end processing GO:0031123 34 17 1,000 2,866E-03 0,02022131 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 2,866E-03 0,02016218 ! regulation of heart contraction GO:0008016 110 60 2,000 2,885E-03 0,02023868 ! negative regulation of response to stimulus GO:0048585 100 60 2,000 2,885E-03 0,02017985 ! kidney development GO:0001822 122 60 2,000 2,885E-03 0,02012135 ! mesoderm development GO:0007498 119 61 2,000 3,024E-03 0,02102878 ! response to peptide hormone stimulus GO:0043434 122 61 2,000 3,024E-03 0,02096818 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 3,214E-03 0,02222267 ! protein amino acid ADP-ribosylation GO:0006471 33 18 1,000 3,214E-03 0,022159 ! epidermis morphogenesis GO:0048730 40 18 1,000 3,214E-03 0,02209569 ! response to retinoic acid GO:0032526 26 18 1,000 3,214E-03 0,02203274 ! cell-substrate junction assembly GO:0007044 54 18 1,000 3,214E-03 0,02197014 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 3,214E-03 0,02190791 ! nerve development GO:0021675 28 18 1,000 3,214E-03 0,02184602 ! steroid hormone receptor signaling pathway GO:0030518 129 63 2,000 3,314E-03 0,02246032 ! positive regulation of angiogenesis GO:0045766 44 19 1,000 3,581E-03 0,02420416 ! lipid phosphorylation GO:0046834 35 19 1,000 3,581E-03 0,02413636 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 3,581E-03 0,02406894 ! cellular response to unfolded protein GO:0034620 33 19 1,000 3,581E-03 0,0240019 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 1,000 3,581E-03 0,02393523 ! neuromuscular junction development GO:0007528 34 19 1,000 3,581E-03 0,02386893 ! plasma membrane fusion GO:0045026 28 19 1,000 3,581E-03 0,02380299 ! regulation of endothelial cell migration GO:0010594 44 19 1,000 3,581E-03 0,02373742 ! cellular pigmentation GO:0033059 36 19 1,000 3,581E-03 0,0236722 ! germ cell development GO:0007281 118 65 2,000 3,62E-03 0,02386435 ! extracellular matrix organization GO:0030198 133 66 2,000 3,78E-03 0,02484726 ! chromosome segregation GO:0007059 113 67 2,000 3,943E-03 0,02585249 ! homeostasis of number of cells GO:0048872 114 67 2,000 3,943E-03 0,02578224 ! protein amino acid acetylation GO:0006473 39 20 1,000 3,967E-03 0,02586613 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 3,967E-03 0,02579623 ! response to vitamin GO:0033273 31 20 1,000 3,967E-03 0,02572669 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 3,967E-03 0,02565754 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 38 20 1,000 3,967E-03 0,02558875 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 3,967E-03 0,02552033 ! negative regulation of angiogenesis GO:0016525 45 20 1,000 3,967E-03 0,02545228 ! negative regulation of translation GO:0017148 29 20 1,000 3,967E-03 0,02538458 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 2,000 4,111E-03 0,02623838 ! ovarian follicle development GO:0001541 35 21 1,000 4,371E-03 0,02782227 ! cell aging GO:0007569 44 21 1,000 4,371E-03 0,02774886 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 1,000 4,371E-03 0,02767584 ! oogenesis GO:0048477 36 21 1,000 4,371E-03 0,0276032 ! DNA modification GO:0006304 34 21 1,000 4,371E-03 0,02753094 ! response to cytokine stimulus GO:0034097 63 21 1,000 4,371E-03 0,02745906 ! gut development GO:0048565 39 21 1,000 4,371E-03 0,02738755 ! sulfur amino acid metabolic process GO:0000096 41 22 1,000 4,793E-03 0,02995558 ! regeneration GO:0031099 41 22 1,000 4,793E-03 0,02987797 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 4,793E-03 0,02980077 ! vesicle docking during exocytosis GO:0006904 41 22 1,000 4,793E-03 0,02972396 ! ureteric bud development GO:0001657 43 22 1,000 4,793E-03 0,02964755 ! renal system process GO:0003014 41 22 1,000 4,793E-03 0,02957153 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 4,793E-03 0,0294959 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 4,793E-03 0,02942066 ! positive regulation of B cell activation GO:0050871 38 22 1,000 4,793E-03 0,0293458 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 4,793E-03 0,02927131 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 1,000 4,793E-03 0,02919721 ! regulation of caspase activity GO:0043281 122 72 2,000 4,826E-03 0,02932278 ! regulation of endopeptidase activity GO:0052548 125 74 2,000 5,21E-03 0,03157479 ! eye development GO:0001654 143 74 2,000 5,21E-03 0,03149545 ! positive regulation of DNA replication GO:0045740 43 23 1,000 5,234E-03 0,03155992 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 5,234E-03 0,03148102 ! response to ethanol GO:0045471 46 23 1,000 5,234E-03 0,03140251 ! activation of pro-apoptotic gene products GO:0008633 47 23 1,000 5,234E-03 0,0313244 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 5,409E-03 0,03229025 ! lymphocyte differentiation GO:0030098 167 75 2,000 5,409E-03 0,03221032 ! regulation of cellular catabolic process GO:0031329 52 24 1,000 5,692E-03 0,03381463 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 1,000 5,692E-03 0,03373134 ! vesicle docking GO:0048278 47 24 1,000 5,692E-03 0,03364847 ! multicellular organismal response to stress GO:0033555 49 24 1,000 5,692E-03 0,03356599 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 5,692E-03 0,03348393 ! lymphocyte proliferation GO:0046651 48 24 1,000 5,692E-03 0,03340226 ! pallium development GO:0021543 49 24 1,000 5,692E-03 0,03332099 ! leukocyte homeostasis GO:0001776 44 24 1,000 5,692E-03 0,03324011 ! aspartate family amino acid metabolic process GO:0009066 42 24 1,000 5,692E-03 0,03315963 ! negative regulation of organelle organization GO:0010639 161 78 2,000 6,031E-03 0,03505187 ! response to steroid hormone stimulus GO:0048545 137 78 2,000 6,031E-03 0,03496741 ! myelination GO:0042552 45 25 1,000 6,168E-03 0,03567314 ! chromosome condensation GO:0030261 45 25 1,000 6,168E-03 0,03558759 ! neural crest cell development GO:0014032 54 25 1,000 6,168E-03 0,03550246 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 73 25 1,000 6,168E-03 0,03541772 GO:0050768|negative regulation of neurogenesis, ! somitogenesis GO:0001756 43 25 1,000 6,168E-03 0,0353334 ! telomere organization GO:0032200 43 25 1,000 6,168E-03 0,03524947 GO:0000723|telomere maintenance, ! regulation of peptidase activity GO:0052547 134 79 2,000 6,248E-03 0,03562301 ! molting cycle process GO:0022404 50 26 1,000 6,661E-03 0,03788958 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 48 26 1,000 6,661E-03 0,03780021 ! insulin receptor signaling pathway GO:0008286 64 26 1,000 6,661E-03 0,03771127 ! response to estradiol stimulus GO:0032355 40 26 1,000 6,661E-03 0,03762275 ! positive regulation of nuclear division GO:0051785 40 26 1,000 6,661E-03 0,03753464 GO:0045840|positive regulation of mitosis, ! group transfer coenzyme metabolic process GO:0006752 47 26 1,000 6,661E-03 0,03744694 ! leukocyte proliferation GO:0070661 52 26 1,000 6,661E-03 0,03735965 GO:0032943|mononuclear cell proliferation, ! T cell activation GO:0042110 168 81 2,000 6,695E-03 0,03746289 ! regulation of neuron differentiation GO:0045664 167 81 2,000 6,695E-03 0,03737597 ! response to drug GO:0042493 143 82 2,000 6,926E-03 0,03857374 ! response to nutrient GO:0007584 125 82 2,000 6,926E-03 0,03848465 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 7,172E-03 0,03976106 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 7,172E-03 0,03966966 ! protein amino acid acylation GO:0043543 55 27 1,000 7,172E-03 0,03957867 ! mitochondrial membrane organization GO:0007006 57 27 1,000 7,172E-03 0,0394881 ! response to toxin GO:0009636 47 27 1,000 7,172E-03 0,03939795 ! regulation of chromosome organization GO:0033044 42 27 1,000 7,172E-03 0,0393082 ! negative regulation of neuron differentiation GO:0045665 42 27 1,000 7,172E-03 0,03921886 ! negative regulation of transport GO:0051051 153 84 2,000 7,401E-03 0,04037925 ! one-carbon metabolic process GO:0006730 154 85 2,000 7,646E-03 0,04161977 ! dendrite development GO:0016358 59 28 1,000 7,7E-03 0,04182086 ! tube morphogenesis GO:0035239 176 86 2,000 7,895E-03 0,04278383 ! response to organic cyclic substance GO:0014070 55 29 1,000 8,245E-03 0,04457956 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 8,245E-03 0,0444796 ! cellular response to extracellular stimulus GO:0031668 48 29 1,000 8,245E-03 0,0443801 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 1,000 8,245E-03 0,04428103 ! negative regulation of neuron apoptosis GO:0043524 56 29 1,000 8,245E-03 0,04418241 ! tissue homeostasis GO:0001894 48 29 1,000 8,245E-03 0,04408423 GO:0048871|multicellular organismal homeostasis, ! membrane docking GO:0022406 61 30 1,000 8,807E-03 0,04698376 ! cell junction assembly GO:0034329 78 30 1,000 8,807E-03 0,04687981 ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 8,807E-03 0,04677633 ! ensheathment of neurons GO:0007272 57 30 1,000 8,807E-03 0,04667329 GO:0008366|axon ensheathment, ! response to heat GO:0009408 50 30 1,000 8,807E-03 0,04657072 ! ossification GO:0001503 188 90 2,000 8,941E-03 0,04717382 ! bone development GO:0060348 189 91 2,000 9,214E-03 0,04850991 ! response to protein stimulus GO:0051789 149 91 2,000 9,214E-03 0,04840399 ! collagen metabolic process GO:0032963 45 31 1,000 9,386E-03 0,04919729 ! ovulation cycle process GO:0022602 49 31 1,000 9,386E-03 0,04909034 ! iron ion homeostasis GO:0055072 54 31 1,000 9,386E-03 0,04898385 ! erythrocyte differentiation GO:0030218 55 31 1,000 9,386E-03 0,04887782 ! myeloid leukocyte activation GO:0002274 49 31 1,000 9,386E-03 0,04877226 ! regulation of defense response GO:0031347 149 92 2,000 9,492E-03 0,04922082 ! carbohydrate biosynthetic process GO:0016051 141 93 2,000 9,775E-03 0,05057979 ! regulation of membrane potential GO:0042391 164 93 2,000 9,775E-03 0,05047125 ! negative regulation of multicellular organismal process GO:0051241 166 93 2,000 9,775E-03 0,05036318 ! response to hydrogen peroxide GO:0042542 50 32 1,000 9,981E-03 0,05131012 ! spindle organization GO:0007051 46 32 1,000 9,981E-03 0,05120072 ! response to ionizing radiation GO:0010212 65 32 1,000 9,981E-03 0,05109178 ! ovulation cycle GO:0042698 51 32 1,000 9,981E-03 0,0509833 ! peripheral nervous system development GO:0007422 64 32 1,000 9,981E-03 0,05087529 ! positive regulation of catabolic process GO:0009896 64 32 1,000 9,981E-03 0,05076773 ! regulation of T cell activation GO:0050863 158 94 2,000 0,01006338 0,05108121 ! forebrain development GO:0030900 188 95 2,000 0,01035626 0,05245719 ! DNA damage checkpoint GO:0000077 71 33 1,000 0,01059186 0,05353786 ! post-embryonic development GO:0009791 69 33 1,000 0,01059186 0,05342562 ! leukocyte differentiation GO:0002521 202 96 2,000 0,01065406 0,05362691 ! regulation of protein localization GO:0032880 176 97 2,000 0,01095678 0,05503552 ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,01121937 0,05623711 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 1,000 0,01121937 0,05612019 ! placenta development GO:0001890 53 34 1,000 0,01121937 0,05600376 ! regulation of muscle development GO:0048634 70 35 1,000 0,01186289 0,05909341 ! negative regulation of cell adhesion GO:0007162 81 35 1,000 0,01186289 0,05897131 ! odontogenesis GO:0042476 66 35 1,000 0,01186289 0,05884972 ! embryonic skeletal system morphogenesis GO:0048704 59 35 1,000 0,01186289 0,05872863 ! female gonad development GO:0008585 58 35 1,000 0,01186289 0,05860804 ! telencephalon development GO:0021537 68 35 1,000 0,01186289 0,05848794 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,01186289 0,05836834 ! regulation of microtubule-based process GO:0032886 78 35 1,000 0,01186289 0,05824922 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,01252225 0,06136159 ! cell junction organization GO:0034330 86 36 1,000 0,01252225 0,06123687 ! positive regulation of cell development GO:0010720 80 36 1,000 0,01252225 0,06111266 ! DNA integrity checkpoint GO:0031570 75 36 1,000 0,01252225 0,06098895 ! embryonic organ development GO:0048568 57 36 1,000 0,01252225 0,06086574 ! meiosis I GO:0007127 65 37 1,000 0,0131973 0,06401753 ! sister chromatid segregation GO:0000819 58 37 1,000 0,0131973 0,06388873 ! glycogen metabolic process GO:0005977 61 37 1,000 0,0131973 0,06376044 ! pigment metabolic process GO:0042440 80 37 1,000 0,0131973 0,06363266 ! cellular response to insulin stimulus GO:0032869 82 37 1,000 0,0131973 0,06350539 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,01388786 0,06669501 ! mitotic cell cycle checkpoint GO:0007093 76 38 1,000 0,01388786 0,06656215 ! development of primary female sexual characteristics GO:0046545 67 38 1,000 0,01388786 0,06642982 GO:0046660|female sex differentiation, ! erythrocyte homeostasis GO:0034101 64 38 1,000 0,01388786 0,06629801 ! positive regulation of leukocyte proliferation GO:0070665 62 38 1,000 0,01388786 0,06616673 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 62 38 1,000 0,01388786 0,06603597 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 86 39 1,000 0,01459379 0,06925575 ! segmentation GO:0035282 67 39 1,000 0,01459379 0,06911942 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,01459379 0,06898362 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,01531493 0,07225042 ! cytokinesis GO:0000910 72 40 1,000 0,01531493 0,07210903 ! female gamete generation GO:0007292 61 41 1,000 0,01605111 0,07542767 ! dorsal/ventral pattern formation GO:0009953 68 41 1,000 0,01605111 0,07528064 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,01680218 0,07864991 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of protein complex disassembly GO:0043242 101 42 1,000 0,01680218 0,07849719 ! regulation of intracellular protein transport GO:0033157 80 42 1,000 0,01680218 0,07834506 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,01756799 0,08175743 ! striated muscle cell differentiation GO:0051146 82 43 1,000 0,01756799 0,0815996 ! heterocycle biosynthetic process GO:0018130 69 43 1,000 0,01756799 0,08144238 ! biopolymer methylation GO:0043414 84 44 1,000 0,01834839 0,08489658 ! B cell differentiation GO:0030183 107 44 1,000 0,01834839 0,08473363 ! developmental growth GO:0048589 82 44 1,000 0,01834839 0,08457131 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 1,000 0,01995232 0,09178831 ! response to insulin stimulus GO:0032868 95 46 1,000 0,01995232 0,09161314 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,01995232 0,09143864 ! response to calcium ion GO:0051592 81 47 1,000 0,02077556 0,0950304 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,02077556 0,09485008 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,02077556 0,09467043 ! methylation GO:0032259 90 47 1,000 0,02077556 0,09449147 ! mitochondrial transport GO:0006839 82 48 1,000 0,02161277 0,09811383 ! regulation of action potential GO:0001508 95 49 1,000 0,02246382 0,10178522 ! regulation of protein complex disassembly GO:0043244 113 49 1,000 0,02246382 0,1015939 ! response to temperature stimulus GO:0009266 76 49 1,000 0,02246382 0,10140329 ! regulation of ossification GO:0030278 117 50 1,000 0,02332855 0,10510955 ! histone modification GO:0016570 91 50 1,000 0,02332855 0,10491308 ! regulation of gene expression, epigenetic GO:0040029 105 50 1,000 0,02332855 0,10471735 ! positive regulation of cytokine production GO:0001819 86 50 1,000 0,02332855 0,10452235 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,023355 0,10444634 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,023355 0,10425256 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,023355 0,1040595 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,023355 0,10386715 ! neuron fate determination GO:0048664 7 5 0,000 0,023355 0,10367552 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,023355 0,10348459 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,023355 0,10329436 ! polyol transport GO:0015791 12 5 0,000 0,023355 0,10310483 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,023355 0,10291599 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,023355 0,10272784 ! response to superoxide GO:0000303 10 5 0,000 0,023355 0,10254038 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,023355 0,10235361 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,023355 0,10216751 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,023355 0,10198209 ! female meiosis GO:0007143 7 5 0,000 0,023355 0,10179734 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,023355 0,10161326 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,023355 0,10142984 ! cobalt ion transport GO:0006824 11 5 0,000 0,023355 0,10124708 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,023355 0,10106498 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,023355 0,10088354 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,023355 0,10070274 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,023355 0,10052259 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,023355 0,10034309 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,023355 0,10016423 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,023355 0,099986 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,023355 0,0998084 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,023355 0,09963144 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,023355 0,0994551 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,023355 0,09927938 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,023355 0,09910429 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,023355 0,09892981 ! negative chemotaxis GO:0050919 14 5 0,000 0,023355 0,09875594 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,023355 0,09858269 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,023355 0,09841004 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,023355 0,09823799 ! behavioral response to pain GO:0048266 9 5 0,000 0,023355 0,09806655 ! clathrin coat assembly GO:0048268 14 5 0,000 0,023355 0,0978957 ! Notch receptor processing GO:0007220 8 5 0,000 0,023355 0,09772544 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,023355 0,09755578 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,023355 0,09738671 ! micturition GO:0060073 9 5 0,000 0,023355 0,09721822 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,023355 0,09705031 ! copulation GO:0007620 9 5 0,000 0,023355 0,09688298 ! glial cell fate commitment GO:0021781 13 5 0,000 0,023355 0,09671623 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,023355 0,09655005 ! spermidine metabolic process GO:0008216 7 5 0,000 0,023355 0,09638444 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,023355 0,0962194 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,023355 0,09605492 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,023355 0,09589101 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,023355 0,09572765 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,023355 0,09556485 ! grooming behavior GO:0007625 6 5 0,000 0,023355 0,0954026 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,023355 0,0952409 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,023355 0,09507975 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,023355 0,09491914 ! response to protozoan GO:0001562 10 5 0,000 0,023355 0,09475907 ! lymph vessel development GO:0001945 10 5 0,000 0,023355 0,09459955 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,023355 0,09444056 ! endochondral ossification GO:0001958 16 5 0,000 0,023355 0,0942821 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,023355 0,09412417 ! parathyroid gland development GO:0060017 13 5 0,000 0,023355 0,09396677 ! anagen GO:0042640 6 5 0,000 0,023355 0,0938099 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,023355 0,09365355 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,023355 0,09349772 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,023355 0,09334241 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,023355 0,09318761 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,023355 0,09303333 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,023355 0,09287955 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,023355 0,09272629 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,023355 0,09257353 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,023355 0,09242127 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,023355 0,09226951 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,023355 0,09211825 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,023355 0,09196748 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 8 5 0,000 0,023355 0,09181721 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,023355 0,09166742 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,023355 0,09151813 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,023355 0,09136932 ! valine metabolic process GO:0006573 10 5 0,000 0,023355 0,09122099 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,023355 0,09107315 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,023355 0,09092578 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,023355 0,09077889 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,023355 0,09063247 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,023355 0,09048652 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,023355 0,09034105 ! polyol catabolic process GO:0046174 7 5 0,000 0,023355 0,09019604 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,023355 0,09005149 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,023355 0,08990741 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,023355 0,08976379 ! muscle cell migration GO:0014812 8 5 0,000 0,023355 0,08962062 ! mitochondrial fission GO:0000266 8 5 0,000 0,023355 0,08947791 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,023355 0,08933566 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,023355 0,08919386 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,023355 0,0890525 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,023355 0,0889116 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,023355 0,08877114 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,023355 0,08863112 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,023355 0,08849154 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,023355 0,08835241 ! response to food GO:0032094 6 5 0,000 0,023355 0,08821371 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,023355 0,08807544 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,023355 0,08793761 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,023355 0,0878002 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,023355 0,08766323 ! forebrain neuron development GO:0021884 13 5 0,000 0,023355 0,08752668 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,023355 0,08739056 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,023355 0,08725486 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,023355 0,08711958 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,023355 0,08698472 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,023355 0,08685028 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,023355 0,08671625 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,023355 0,08658264 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,023355 0,08644943 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,023355 0,08631664 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,023355 0,08618425 ! basic amino acid transport GO:0015802 11 5 0,000 0,023355 0,08605227 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,023355 0,08592069 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,023355 0,08578951 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,023355 0,08565874 ! depyrimidination GO:0045008 10 5 0,000 0,023355 0,08552836 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,023355 0,08539837 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,023355 0,08526879 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,023355 0,08513959 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,023355 0,08501079 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,023355 0,08488237 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,023355 0,08475434 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,023355 0,0846267 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,023355 0,08449944 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,023355 0,08437257 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,023355 0,08424607 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,023355 0,08411996 ! response to arsenic GO:0046685 10 5 0,000 0,023355 0,08399422 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,023355 0,08386885 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,023355 0,08374386 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,023355 0,08361924 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,023355 0,08349499 ! response to cadmium ion GO:0046686 7 5 0,000 0,023355 0,08337111 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,023355 0,0832476 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,023355 0,08312445 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,023355 0,08300167 ! decidualization GO:0046697 11 5 0,000 0,023355 0,08287925 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,023355 0,08275719 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,023355 0,08263549 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,023355 0,08251414 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,023355 0,08239315 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,023355 0,08227252 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,023355 0,08215224 ! neural tube patterning GO:0021532 7 5 0,000 0,023355 0,08203231 ! embryonic cleavage GO:0040016 6 5 0,000 0,023355 0,08191273 ! peroxisome fission GO:0016559 5 5 0,000 0,023355 0,08179349 ! histone demethylation GO:0016577 10 5 0,000 0,023355 0,08167461 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,023355 0,08155607 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,023355 0,08143787 ! metaphase plate congression GO:0051310 7 5 0,000 0,023355 0,08132002 ! regulation of sterol transport GO:0032371 7 5 0,000 0,023355 0,0812025 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,023355 0,08108533 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,023355 0,08096849 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,023355 0,08085199 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,023355 0,08073582 ! muscle cell proliferation GO:0033002 11 5 0,000 0,023355 0,08061999 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,023355 0,08050449 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,023355 0,08038931 ! plasminogen activation GO:0031639 5 5 0,000 0,023355 0,08027447 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,023355 0,08015996 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,023355 0,08004577 ! metaphase GO:0051323 8 5 0,000 0,023355 0,07993191 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,023355 0,07981837 ! cellular response to nutrient GO:0031670 8 5 0,000 0,023355 0,07970515 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,023355 0,07959225 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,023355 0,07947968 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,023355 0,07936742 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,023355 0,07925547 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,023355 0,07914385 ! response to redox state GO:0051775 5 5 0,000 0,023355 0,07903253 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,023355 0,07892153 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,023355 0,07881084 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,023355 0,07870046 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,023355 0,07859039 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,023355 0,07848063 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,023355 0,07837117 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,023355 0,07826202 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,023355 0,07815317 ! striatum development GO:0021756 9 5 0,000 0,023355 0,07804463 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,023355 0,07793638 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,023355 0,07782844 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,023355 0,07772079 ! glial cell migration GO:0008347 11 5 0,000 0,023355 0,07761344 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,023355 0,07750639 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,023355 0,07739963 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,023355 0,07729316 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,023355 0,07718699 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,023355 0,07708111 ! neuroprotection GO:0043526 6 5 0,000 0,023355 0,07697552 ! neural plate development GO:0001840 8 5 0,000 0,023355 0,07687022 ! regulation of sensory perception GO:0051931 7 5 0,000 0,023355 0,07676521 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,023355 0,07666048 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,023355 0,07655604 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,023355 0,07645188 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,023355 0,076348 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,023355 0,07624441 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,023355 0,0761411 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,023355 0,07603807 ! spindle assembly GO:0051225 6 5 0,000 0,023355 0,07593531 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,023355 0,07583283 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,023355 0,07573063 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,023355 0,07562871 ! drug metabolic process GO:0017144 6 5 0,000 0,023355 0,07552706 ! phospholipid scrambling GO:0017121 8 5 0,000 0,023355 0,07542568 ! organ regeneration GO:0031100 7 5 0,000 0,023355 0,07532457 ! carnitine metabolic process GO:0009437 7 5 0,000 0,023355 0,07522374 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,023355 0,07512317 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,023355 0,07502287 ! positive regulation of binding GO:0051099 78 51 1,000 0,02420683 0,0776555 ! cellular amino acid biosynthetic process GO:0008652 75 51 1,000 0,02420683 0,07755209 ! embryonic skeletal system development GO:0048706 85 51 1,000 0,02420683 0,07744897 ! vesicle organization GO:0016050 107 51 1,000 0,02420683 0,07734611 ! regulation of cell shape GO:0008360 125 51 1,000 0,02420683 0,07724353 ! epithelial tube morphogenesis GO:0060562 98 51 1,000 0,02420683 0,07714122 ! membrane fusion GO:0006944 110 52 1,000 0,02509849 0,07987695 ! positive regulation of growth GO:0045927 90 52 1,000 0,02509849 0,07977143 ! covalent chromatin modification GO:0016569 101 52 1,000 0,02509849 0,07966619 ! amino acid activation GO:0043038 92 52 1,000 0,02509849 0,07956123 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! synapse organization GO:0050808 85 52 1,000 0,02509849 0,07945654 ! cell maturation GO:0048469 100 53 1,000 0,02600341 0,08221314 ! regulation of neuron apoptosis GO:0043523 100 53 1,000 0,02600341 0,08210525 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,02692143 0,08489248 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 1,000 0,02692143 0,08478137 ! heterocycle catabolic process GO:0046700 85 54 1,000 0,02692143 0,08467054 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 0,02785242 0,08748423 ! sulfur compound biosynthetic process GO:0044272 93 55 1,000 0,02785242 0,08737017 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,02785242 0,08725641 ! heart morphogenesis GO:0003007 97 55 1,000 0,02785242 0,08714294 ! regulation of multicellular organism growth GO:0040014 85 55 1,000 0,02785242 0,08702977 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02796059 0,08725446 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02796059 0,08714143 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,02796059 0,0870287 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02796059 0,08691626 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02796059 0,08680411 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,02796059 0,08669225 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,02796059 0,08658068 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02796059 0,08646939 ! sleep GO:0030431 13 6 0,000 0,02796059 0,08635839 ! response to oxygen radical GO:0000305 11 6 0,000 0,02796059 0,08624767 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,02796059 0,08613724 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,02796059 0,08602709 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,02796059 0,08591722 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02796059 0,08580763 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,02796059 0,08569833 ! forebrain regionalization GO:0021871 8 6 0,000 0,02796059 0,08558929 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02796059 0,08548054 ! male meiosis GO:0007140 7 6 0,000 0,02796059 0,08537206 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02796059 0,08526386 ! response to zinc ion GO:0010043 9 6 0,000 0,02796059 0,08515593 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02796059 0,08504827 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,02796059 0,08494089 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,02796059 0,08483378 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02796059 0,08472693 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02796059 0,08462036 ! malate metabolic process GO:0006108 11 6 0,000 0,02796059 0,08451405 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,02796059 0,08440801 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,02796059 0,08430224 ! protein refolding GO:0042026 15 6 0,000 0,02796059 0,08419673 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02796059 0,08409148 ! opsonization GO:0008228 8 6 0,000 0,02796059 0,0839865 ! mating behavior GO:0007617 7 6 0,000 0,02796059 0,08388178 ! neuron remodeling GO:0016322 15 6 0,000 0,02796059 0,08377732 ! erythrocyte maturation GO:0043249 7 6 0,000 0,02796059 0,08367312 ! equilibrioception GO:0050957 14 6 0,000 0,02796059 0,08356917 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,02796059 0,08346549 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,02796059 0,08336206 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02796059 0,08325889 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,02796059 0,08315598 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02796059 0,08305332 ! response to interferon-gamma GO:0034341 15 6 0,000 0,02796059 0,08295091 ! toxin metabolic process GO:0009404 11 6 0,000 0,02796059 0,08284875 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02796059 0,08274685 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02796059 0,08264519 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,02796059 0,08254379 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,02796059 0,08244263 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,02796059 0,08234172 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,02796059 0,08224106 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02796059 0,08214064 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,02796059 0,08204047 ! thymic T cell selection GO:0045061 12 6 0,000 0,02796059 0,08194054 ! protein lipoylation GO:0009249 10 6 0,000 0,02796059 0,08184086 ! cysteine metabolic process GO:0006534 10 6 0,000 0,02796059 0,08174142 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02796059 0,08164222 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02796059 0,08154325 ! glutamate catabolic process GO:0006538 10 6 0,000 0,02796059 0,08144453 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,02796059 0,08134605 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02796059 0,08124781 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,02796059 0,0811498 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,02796059 0,08105203 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02796059 0,08095449 ! hyperosmotic response GO:0006972 9 6 0,000 0,02796059 0,08085719 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,02796059 0,08076013 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,02796059 0,08066329 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02796059 0,08056669 ! urea metabolic process GO:0019627 7 6 0,000 0,02796059 0,08047032 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02796059 0,08037418 ! neutrophil activation GO:0042119 8 6 0,000 0,02796059 0,08027826 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02796059 0,08018258 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,02796059 0,08008713 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02796059 0,0799919 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02796059 0,07989689 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02796059 0,07980212 ! neuron apoptosis GO:0051402 9 6 0,000 0,02796059 0,07970757 ! nucleoside salvage GO:0043174 9 6 0,000 0,02796059 0,07961324 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,02796059 0,07951913 ! T cell mediated immunity GO:0002456 16 6 0,000 0,02796059 0,07942525 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02796059 0,07933159 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,02796059 0,07923815 ! carnitine transport GO:0015879 10 6 0,000 0,02796059 0,07914492 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,02796059 0,07905192 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02796059 0,07895914 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,02796059 0,07886657 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,02796059 0,07877422 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,02796059 0,07868209 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02796059 0,07859017 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,02796059 0,07849847 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,02796059 0,07840698 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,02796059 0,0783157 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,02796059 0,07822463 ! monocyte differentiation GO:0030224 12 6 0,000 0,02796059 0,07813378 ! response to UV-C GO:0010225 11 6 0,000 0,02796059 0,07804314 ! astrocyte development GO:0014002 15 6 0,000 0,02796059 0,07795271 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,02796059 0,07786248 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02796059 0,07777247 ! interaction with symbiont GO:0051702 13 6 0,000 0,02796059 0,07768266 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02796059 0,07759306 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02796059 0,07750367 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,02796059 0,07741448 ! response to copper ion GO:0046688 10 6 0,000 0,02796059 0,0773255 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,02796059 0,07723672 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02796059 0,07714815 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02796059 0,07705978 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02796059 0,07697161 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,02796059 0,07688364 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02796059 0,07679587 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,02796059 0,07670831 ! hair follicle maturation GO:0048820 7 6 0,000 0,02796059 0,07662094 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02796059 0,07653377 ! Schwann cell development GO:0014044 15 6 0,000 0,02796059 0,0764468 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,02796059 0,07636003 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02796059 0,07627345 ! subpallium development GO:0021544 10 6 0,000 0,02796059 0,07618707 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,02796059 0,07610089 ! histone ubiquitination GO:0016574 8 6 0,000 0,02796059 0,0760149 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,02796059 0,0759291 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02796059 0,0758435 ! G2 phase GO:0051319 16 6 0,000 0,02796059 0,07575809 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,02796059 0,07567287 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02796059 0,07558785 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,02796059 0,07550301 ! membrane to membrane docking GO:0022614 14 6 0,000 0,02796059 0,07541837 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02796059 0,07533391 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,02796059 0,07524965 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02796059 0,07516557 ! receptor internalization GO:0031623 10 6 0,000 0,02796059 0,07508168 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,02796059 0,07499798 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,02796059 0,07491446 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02796059 0,07483113 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,02796059 0,07474798 ! protein deubiquitination GO:0016579 14 6 0,000 0,02796059 0,07466502 ! negative regulation of neuroblast proliferation GO:0007406 21 6 0,000 0,02796059 0,07458225 ! protein destabilization GO:0031648 9 6 0,000 0,02796059 0,07449965 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02796059 0,07441724 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,02796059 0,07433501 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02796059 0,07425296 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,02796059 0,0741711 ! progesterone metabolic process GO:0042448 10 6 0,000 0,02796059 0,07408941 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,02796059 0,0740079 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,02796059 0,07392658 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,02796059 0,07384543 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,02796059 0,07376446 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02796059 0,07368366 ! determination of adult lifespan GO:0008340 15 6 0,000 0,02796059 0,07360305 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,02796059 0,07352261 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,02796059 0,07344234 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02796059 0,07336225 ! catecholamine transport GO:0051937 9 6 0,000 0,02796059 0,07328234 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,02796059 0,0732026 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02796059 0,07312303 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02796059 0,07304363 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,02796059 0,07296441 ! maternal placenta development GO:0001893 12 6 0,000 0,02796059 0,07288536 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,02796059 0,07280648 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02796059 0,07272777 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,02796059 0,07264923 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02796059 0,07257086 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,02796059 0,07249266 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,02796059 0,07241462 ! positive regulation of organelle organization GO:0010638 100 56 1,000 0,02879623 0,07449864 ! lipid modification GO:0030258 97 57 1,000 0,02975273 0,07689052 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,02975273 0,07680802 ! regulation of intracellular transport GO:0032386 101 57 1,000 0,02975273 0,07672569 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,03072178 0,07913982 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,03170323 0,08158071 ! cytokine-mediated signaling pathway GO:0019221 97 59 1,000 0,03170323 0,08149356 ! DNA catabolic process GO:0006308 86 59 1,000 0,03170323 0,08140658 ! establishment of organelle localization GO:0051656 109 59 1,000 0,03170323 0,0813198 ! tRNA transcription GO:0009304 14 7 0,000 0,03254462 0,08338909 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,03254462 0,08330037 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,03254462 0,08321185 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03254462 0,08312351 ! regulation of helicase activity GO:0051095 15 7 0,000 0,03254462 0,08303537 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,03254462 0,08294741 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,03254462 0,08285963 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03254462 0,08277204 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,03254462 0,08268464 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03254462 0,08259742 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,03254462 0,08251038 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03254462 0,08242353 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03254462 0,08233686 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,03254462 0,08225037 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03254462 0,08216406 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,03254462 0,08207794 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,03254462 0,08199199 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,03254462 0,08190622 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03254462 0,08182064 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,03254462 0,08173523 ! glycolipid transport GO:0046836 10 7 0,000 0,03254462 0,08165 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03254462 0,08156495 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,03254462 0,08148007 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03254462 0,08139538 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,03254462 0,08131085 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03254462 0,08122651 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,03254462 0,08114233 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,03254462 0,08105833 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,03254462 0,08097451 ! pericardium development GO:0060039 14 7 0,000 0,03254462 0,08089086 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,03254462 0,08080738 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,03254462 0,08072407 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,03254462 0,08064094 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03254462 0,08055797 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,03254462 0,08047518 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03254462 0,08039256 ! lipoprotein transport GO:0042953 14 7 0,000 0,03254462 0,0803101 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03254462 0,08022782 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03254462 0,0801457 ! rhythmic behavior GO:0007622 15 7 0,000 0,03254462 0,08006375 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,03254462 0,07998197 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,03254462 0,07990036 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,03254462 0,07981891 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03254462 0,07973763 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,03254462 0,07965651 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03254462 0,07957556 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,03254462 0,07949477 ! mechanosensory behavior GO:0007638 14 7 0,000 0,03254462 0,07941415 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,03254462 0,07933369 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03254462 0,07925339 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,03254462 0,07917326 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03254462 0,07909328 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03254462 0,07901347 ! spinal cord patterning GO:0021511 13 7 0,000 0,03254462 0,07893382 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,03254462 0,07885433 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03254462 0,078775 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,03254462 0,07869583 ! adrenal gland development GO:0030325 17 7 0,000 0,03254462 0,07861682 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,03254462 0,07853796 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,03254462 0,07845927 ! ovulation GO:0030728 9 7 0,000 0,03254462 0,07838073 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,03254462 0,07830235 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,03254462 0,07822413 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,03254462 0,07814606 ! microtubule nucleation GO:0007020 20 7 0,000 0,03254462 0,07806815 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03254462 0,07799039 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03254462 0,07791279 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,03254462 0,07783534 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,03254462 0,07775804 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,03254462 0,0776809 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03254462 0,07760392 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03254462 0,07752708 ! galactose metabolic process GO:0006012 13 7 0,000 0,03254462 0,0774504 ! vesicle fusion GO:0006906 17 7 0,000 0,03254462 0,07737386 ! response to dietary excess GO:0002021 8 7 0,000 0,03254462 0,07729748 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03254462 0,07722125 ! intracellular pH reduction GO:0051452 11 7 0,000 0,03254462 0,07714517 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03254462 0,07706924 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,03254462 0,07699346 ! purine salvage GO:0043101 10 7 0,000 0,03254462 0,07691783 ! nucleoside transport GO:0015858 8 7 0,000 0,03254462 0,07684235 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,03254462 0,07676701 ! parturition GO:0007567 14 7 0,000 0,03254462 0,07669182 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,03254462 0,07661678 ! rRNA modification GO:0000154 14 7 0,000 0,03254462 0,07654189 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,03254462 0,07646714 ! spindle checkpoint GO:0031577 15 7 0,000 0,03254462 0,07639254 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,03254462 0,07631808 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,03254462 0,07624377 ! macrophage differentiation GO:0030225 11 7 0,000 0,03254462 0,0761696 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03254462 0,07609558 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03254462 0,0760217 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,03254462 0,07594796 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,03254462 0,07587437 ! G1 DNA damage checkpoint GO:0031571 21 7 0,000 0,03254462 0,07580092 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03254462 0,07572761 ! fibrinolysis GO:0042730 10 7 0,000 0,03254462 0,07565445 ! eating behavior GO:0042755 7 7 0,000 0,03254462 0,07558142 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03254462 0,07550854 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,03254462 0,07543579 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,03254462 0,07536319 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03254462 0,07529072 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,03254462 0,0752184 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03254462 0,07514621 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,03254462 0,07507416 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,03254462 0,07500225 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,03254462 0,07493048 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03254462 0,07485884 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,03254462 0,07478735 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03254462 0,07471598 ! regulation of meiosis GO:0040020 12 7 0,000 0,03254462 0,07464476 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,03254462 0,07457367 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,03254462 0,07450271 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03254462 0,07443189 ! transcription termination GO:0006353 13 7 0,000 0,03254462 0,07436121 ! response to tumor cell GO:0002347 13 7 0,000 0,03254462 0,07429066 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,03254462 0,07422024 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03254462 0,07414995 ! anaphase GO:0051322 17 7 0,000 0,03254462 0,0740798 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,03254462 0,07400978 ! axonal fasciculation GO:0007413 18 7 0,000 0,03254462 0,0739399 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,03254462 0,07387014 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,03254462 0,07380052 ! diuresis GO:0030146 12 7 0,000 0,03254462 0,07373103 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03254462 0,07366167 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03254462 0,07359244 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03254462 0,07352333 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,03254462 0,07345436 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,03254462 0,07338552 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03254462 0,07331681 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03254462 0,07324822 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03254462 0,07317977 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,03254462 0,07311144 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03254462 0,07304324 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,03254462 0,07297516 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,03254462 0,07290722 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,03254462 0,0728394 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03254462 0,0727717 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,03254462 0,07270413 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,03254462 0,07263669 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,03254462 0,07256937 ! adult feeding behavior GO:0008343 9 7 0,000 0,03254462 0,07250218 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,03254462 0,07243511 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,03254462 0,07236816 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03254462 0,07230134 ! muscle adaptation GO:0043500 14 7 0,000 0,03254462 0,07223464 ! embryonic heart tube development GO:0035050 10 7 0,000 0,03254462 0,07216807 ! retina homeostasis GO:0001895 12 7 0,000 0,03254462 0,07210161 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,03254462 0,07203528 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,03254462 0,07196907 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,03254462 0,07190299 ! protein prenylation GO:0018342 18 7 0,000 0,03254462 0,07183702 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,03254462 0,07177117 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,03254462 0,07170545 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03254462 0,07163985 ! DNA damage response, signal transduction GO:0042770 128 60 1,000 0,03269695 0,07190939 ! camera-type eye development GO:0043010 116 60 1,000 0,03269695 0,07184372 ! ear development GO:0043583 103 62 1,000 0,03472067 0,07622075 ! cellular amino acid catabolic process GO:0009063 101 63 1,000 0,0357504 0,07840972 ! regulation of lipid metabolic process GO:0019216 115 63 1,000 0,0357504 0,07833831 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 1,000 0,03679186 0,08054706 ! multicellular organism reproduction GO:0032504 111 64 1,000 0,03679186 0,08047384 GO:0048609|reproductive process in a multicellular organism, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,03710718 0,0810898 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,03710718 0,08101621 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,03710718 0,08094276 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,03710718 0,08086945 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03710718 0,08079626 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03710718 0,08072321 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,03710718 0,08065029 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,03710718 0,0805775 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,03710718 0,08050484 ! meiotic prophase I GO:0007128 13 8 0,000 0,03710718 0,08043231 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03710718 0,08035992 ! oligopeptide transport GO:0006857 15 8 0,000 0,03710718 0,08028765 ! UTP metabolic process GO:0046051 8 8 0,000 0,03710718 0,08021552 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,03710718 0,08014351 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,03710718 0,08007163 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,03710718 0,07999988 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03710718 0,07992826 ! succinate metabolic process GO:0006105 14 8 0,000 0,03710718 0,07985677 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03710718 0,07978541 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,03710718 0,07971417 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,03710718 0,07964306 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,03710718 0,07957208 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03710718 0,07950122 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03710718 0,07943049 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,03710718 0,07935988 ! reflex GO:0060004 16 8 0,000 0,03710718 0,0792894 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,03710718 0,07921905 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,03710718 0,07914882 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03710718 0,07907871 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,03710718 0,07900873 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,03710718 0,07893888 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03710718 0,07886914 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,03710718 0,07879953 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,03710718 0,07873004 ! astrocyte differentiation GO:0048708 18 8 0,000 0,03710718 0,07866068 ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03710718 0,07859143 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,03710718 0,07852231 ! glycine catabolic process GO:0006546 13 8 0,000 0,03710718 0,07845331 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,03710718 0,07838443 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,03710718 0,07831567 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,03710718 0,07824704 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,03710718 0,07817852 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03710718 0,07811012 ! macrophage activation GO:0042116 12 8 0,000 0,03710718 0,07804184 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03710718 0,07797368 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,03710718 0,07790564 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,03710718 0,07783772 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,03710718 0,07776992 ! osteoblast development GO:0002076 16 8 0,000 0,03710718 0,07770224 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,03710718 0,07763467 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,03710718 0,07756722 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,03710718 0,07749989 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,03710718 0,07743267 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,03710718 0,07736557 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03710718 0,07729859 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,03710718 0,07723172 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03710718 0,07716497 ! intermediate filament organization GO:0045109 12 8 0,000 0,03710718 0,07709833 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,03710718 0,07703181 ! cellular extravasation GO:0045123 12 8 0,000 0,03710718 0,0769654 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,03710718 0,07689911 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,03710718 0,07683293 ! response to antibiotic GO:0046677 11 8 0,000 0,03710718 0,07676687 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,03710718 0,07670092 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,03710718 0,07663508 ! response to tropane GO:0014073 15 8 0,000 0,03710718 0,07656936 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,03710718 0,07650374 ! melanosome transport GO:0032402 13 8 0,000 0,03710718 0,07643824 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,03710718 0,07637286 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03710718 0,07630758 ! multicellular organismal aging GO:0010259 18 8 0,000 0,03710718 0,07624242 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,03710718 0,07617736 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,03710718 0,07611242 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,03710718 0,07604759 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03710718 0,07598287 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03710718 0,07591826 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,03710718 0,07585375 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03710718 0,07578936 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03710718 0,07572508 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,03710718 0,07566091 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,03710718 0,07559684 ! intracellular lipid transport GO:0032365 13 8 0,000 0,03710718 0,07553288 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03710718 0,07546904 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03710718 0,07540529 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,03710718 0,07534166 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,03710718 0,07527814 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,03710718 0,07521472 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,03710718 0,0751514 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,03710718 0,0750882 ! hormone catabolic process GO:0042447 17 8 0,000 0,03710718 0,0750251 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03710718 0,07496211 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,03710718 0,07489922 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,03710718 0,07483644 ! ATP catabolic process GO:0006200 11 8 0,000 0,03710718 0,07477376 ! blastocyst growth GO:0001832 19 8 0,000 0,03710718 0,07471119 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,03710718 0,07464872 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03710718 0,07458636 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,03710718 0,0745241 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03710718 0,07446194 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03710718 0,07439989 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,03710718 0,07433794 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,03710718 0,0742761 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,03710718 0,07421435 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,03710718 0,07415272 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,03710718 0,07409118 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,03710718 0,07402974 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03710718 0,07396841 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,03710718 0,07390718 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03710718 0,07384605 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03710718 0,07378502 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,03710718 0,07372409 ! myeloid cell differentiation GO:0030099 111 65 1,000 0,03784493 0,0751278 ! actin filament organization GO:0007015 148 66 1,000 0,03890947 0,07717739 ! secondary metabolic process GO:0019748 116 66 1,000 0,03890947 0,07711382 ! developmental maturation GO:0021700 116 66 1,000 0,03890947 0,07705035 ! cell projection assembly GO:0030031 120 66 1,000 0,03890947 0,07698698 ! adaptive immune response GO:0002250 119 67 1,000 0,03998534 0,07905073 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,04107243 0,08113323 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of lipase activity GO:0060191 130 68 1,000 0,04107243 0,08106668 ! regulation of developmental growth GO:0048638 15 9 0,000 0,04164837 0,08213605 ! axon extension GO:0048675 15 9 0,000 0,04164837 0,08206878 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,04164837 0,08200162 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,04164837 0,08193457 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,04164837 0,08186763 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04164837 0,0818008 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,04164837 0,08173408 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,04164837 0,08166746 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,04164837 0,08160096 ! phosphate transport GO:0006817 19 9 0,000 0,04164837 0,08153456 ! reproductive behavior GO:0019098 19 9 0,000 0,04164837 0,08146828 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04164837 0,0814021 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,04164837 0,08133602 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04164837 0,08127006 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,04164837 0,0812042 ! GTP metabolic process GO:0046039 9 9 0,000 0,04164837 0,08113844 ! RNA methylation GO:0001510 15 9 0,000 0,04164837 0,0810728 ! elastic fiber assembly GO:0048251 15 9 0,000 0,04164837 0,08100726 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,04164837 0,08094182 ! artery development GO:0060840 24 9 0,000 0,04164837 0,0808765 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,04164837 0,08081127 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,04164837 0,08074616 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,04164837 0,08068114 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,04164837 0,08061623 ! chemosensory behavior GO:0007635 20 9 0,000 0,04164837 0,08055143 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,04164837 0,08048673 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,04164837 0,08042213 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04164837 0,08035764 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,04164837 0,08029325 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,04164837 0,08022897 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,04164837 0,08016478 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04164837 0,0801007 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04164837 0,08003672 ! protein targeting to ER GO:0045047 22 9 0,000 0,04164837 0,07997285 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,04164837 0,07990907 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,04164837 0,0798454 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,04164837 0,07978183 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04164837 0,07971836 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,04164837 0,07965499 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04164837 0,07959172 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04164837 0,07952856 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04164837 0,07946549 ! mannose metabolic process GO:0006013 13 9 0,000 0,04164837 0,07940252 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,04164837 0,07933965 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,04164837 0,07927688 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,04164837 0,07921421 ! receptor clustering GO:0043113 18 9 0,000 0,04164837 0,07915164 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,04164837 0,07908917 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04164837 0,0790268 ! ruffle organization GO:0031529 15 9 0,000 0,04164837 0,07896452 ! retinol metabolic process GO:0042572 18 9 0,000 0,04164837 0,07890235 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,04164837 0,07884027 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,04164837 0,07877829 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,04164837 0,0787164 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,04164837 0,07865461 GO:0030204|chondroitin sulfate metabolic process, ! protein heterooligomerization GO:0051291 16 9 0,000 0,04164837 0,07859292 ! oligodendrocyte development GO:0014003 10 9 0,000 0,04164837 0,07853133 ! segment specification GO:0007379 13 9 0,000 0,04164837 0,07846984 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04164837 0,07840843 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,04164837 0,07834713 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04164837 0,07828592 ! response to amine stimulus GO:0014075 13 9 0,000 0,04164837 0,07822481 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04164837 0,07816379 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,04164837 0,07810287 ! erythrocyte development GO:0048821 15 9 0,000 0,04164837 0,07804204 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04164837 0,07798131 ! renal water homeostasis GO:0003091 14 9 0,000 0,04164837 0,07792067 ! postreplication repair GO:0006301 22 9 0,000 0,04164837 0,07786012 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,04164837 0,07779967 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,04164837 0,07773932 ! icosanoid secretion GO:0032309 15 9 0,000 0,04164837 0,07767905 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,04164837 0,07761888 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04164837 0,07755881 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,04164837 0,07749882 ! regulation of cell division GO:0051302 15 9 0,000 0,04164837 0,07743893 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,04164837 0,07737913 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,04164837 0,07731943 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04164837 0,07725981 ! sterol catabolic process GO:0016127 11 9 0,000 0,04164837 0,07720029 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04164837 0,07714086 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,04164837 0,07708152 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,04164837 0,07702227 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,04164837 0,07696312 GO:0000084|S phase of mitotic cell cycle, ! musculoskeletal movement GO:0050881 14 9 0,000 0,04164837 0,07690405 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,04164837 0,07684508 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,04164837 0,07678619 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04164837 0,0767274 ! purine base metabolic process GO:0006144 21 9 0,000 0,04164837 0,07666869 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,04164837 0,07661008 ! pigment granule transport GO:0051904 17 9 0,000 0,04164837 0,07655155 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,04164837 0,07649311 ! regulation of telomere maintenance GO:0032204 14 9 0,000 0,04164837 0,07643477 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,04164837 0,07637651 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04164837 0,07631834 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04164837 0,07626026 ! mitochondrion localization GO:0051646 15 9 0,000 0,04164837 0,07620227 ! coenzyme biosynthetic process GO:0009108 102 69 1,000 0,04217061 0,07709916 ! amine catabolic process GO:0009310 117 71 1,000 0,04439971 0,08111291 ! humoral immune response GO:0006959 109 71 1,000 0,04439971 0,08105137 ! B cell activation GO:0042113 160 71 1,000 0,04439971 0,08098992 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,04553038 0,08298947 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,0461683 0,08408851 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,0461683 0,0840249 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,0461683 0,08396139 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0461683 0,08389798 ! synapsis GO:0007129 13 10 0,000 0,0461683 0,08383466 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,0461683 0,08377143 ! N-glycan processing GO:0006491 20 10 0,000 0,0461683 0,08370831 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,0461683 0,08364527 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,0461683 0,08358233 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,0461683 0,08351949 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,0461683 0,08345674 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,0461683 0,08339408 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,0461683 0,08333152 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,0461683 0,08326906 ! androgen metabolic process GO:0008209 17 10 0,000 0,0461683 0,08320668 ! phospholipid efflux GO:0033700 16 10 0,000 0,0461683 0,0831444 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,0461683 0,08308221 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,0461683 0,08302012 ! pathogenesis GO:0009405 13 10 0,000 0,0461683 0,08295812 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0461683 0,08289621 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,0461683 0,08283439 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,0461683 0,08277267 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,0461683 0,08271104 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,0461683 0,08264949 ! endoderm development GO:0007492 16 10 0,000 0,0461683 0,08258805 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,0461683 0,08252669 ! arginine catabolic process GO:0006527 13 10 0,000 0,0461683 0,08246542 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0461683 0,08240424 ! proline metabolic process GO:0006560 13 10 0,000 0,0461683 0,08234316 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,0461683 0,08228216 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,0461683 0,08222126 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,0461683 0,08216044 ! V(D)J recombination GO:0033151 28 10 0,000 0,0461683 0,08209972 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,0461683 0,08203909 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,0461683 0,08197854 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,0461683 0,08191808 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,0461683 0,08185772 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,0461683 0,08179744 ! multicellular organism growth GO:0035264 18 10 0,000 0,0461683 0,08173725 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,0461683 0,08167715 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,0461683 0,08161714 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,0461683 0,08155721 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0461683 0,08149737 ! macroautophagy GO:0016236 17 10 0,000 0,0461683 0,08143763 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,0461683 0,08137796 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,0461683 0,08131839 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,0461683 0,0812589 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 0,000 0,0461683 0,0811995 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0461683 0,08114019 ! brain morphogenesis GO:0048854 23 10 0,000 0,0461683 0,08108096 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,0461683 0,08102182 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,0461683 0,08096277 ! blastoderm segmentation GO:0007350 18 10 0,000 0,0461683 0,0809038 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,0461683 0,08084492 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0461683 0,08078612 ! melanosome localization GO:0032400 16 10 0,000 0,0461683 0,08072741 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,0461683 0,08066879 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,0461683 0,08061025 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,0461683 0,08055179 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0461683 0,08049342 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,0461683 0,08043513 ! mRNA cleavage GO:0006379 17 10 0,000 0,0461683 0,08037693 ! protein sumoylation GO:0016925 15 10 0,000 0,0461683 0,08031882 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0461683 0,08026078 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0461683 0,08020283 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0461683 0,08014496 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,0461683 0,08008718 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,0461683 0,08002948 ! salivary gland development GO:0007431 27 10 0,000 0,0461683 0,07997187 ! prophase GO:0051324 15 10 0,000 0,0461683 0,07991433 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,0461683 0,07985688 ! apical protein localization GO:0045176 15 10 0,000 0,0461683 0,07979951 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,0461683 0,07974223 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,0461683 0,07968502 ! midbrain development GO:0030901 13 10 0,000 0,0461683 0,0796279 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,0461683 0,07957086 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,0461683 0,0795139 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,0461683 0,07945703 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0461683 0,07940023 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0461683 0,07934352 ! detection of calcium ion GO:0005513 23 10 0,000 0,0461683 0,07928688 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0461683 0,07923033 ! blastocyst formation GO:0001825 17 10 0,000 0,0461683 0,07917386 ! cerebellar cortex development GO:0021695 15 10 0,000 0,0461683 0,07911747 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,0461683 0,07906115 ! activation of innate immune response GO:0002218 12 10 0,000 0,0461683 0,07900492 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,0461683 0,07894877 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,0461683 0,0788927 ! establishment of cell polarity GO:0030010 16 10 0,000 0,0461683 0,07883671 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,0461683 0,0787808 ! learning or memory GO:0007611 147 73 1,000 0,04667164 0,07958324 ! axon guidance GO:0007411 139 73 1,000 0,04667164 0,07952688 ! meiosis GO:0007126 121 74 1,000 0,04782335 0,08143169 GO:0051327|M phase of meiotic cell cycle, ! exocytosis GO:0006887 133 74 1,000 0,04782335 0,0813741 ! organelle localization GO:0051640 136 74 1,000 0,04782335 0,08131659 ! cell-matrix adhesion GO:0007160 163 75 1,000 0,0489854 0,08323366 ! meiotic cell cycle GO:0051321 122 75 1,000 0,0489854 0,08317492 ! rhythmic process GO:0048511 128 75 1,000 0,0489854 0,08311627 ! regulation of catabolic process GO:0009894 161 76 1,000 0,05015766 0,08504534 ! negative regulation of muscle development GO:0048635 20 11 0,000 0,05066705 0,08584854 ! respiratory burst GO:0045730 17 11 0,000 0,05066705 0,08578813 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,05066705 0,0857278 ! neuron fate specification GO:0048665 17 11 0,000 0,05066705 0,08566756 ! telencephalon cell migration GO:0022029 20 11 0,000 0,05066705 0,0856074 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,05066705 0,08554732 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,05066705 0,08548733 ! thyroid gland development GO:0030878 26 11 0,000 0,05066705 0,08542742 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,05066705 0,0853676 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,05066705 0,08530786 ! response to pain GO:0048265 24 11 0,000 0,05066705 0,0852482 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,05066705 0,08518863 ! T cell proliferation GO:0042098 26 11 0,000 0,05066705 0,08512914 ! bone resorption GO:0045453 16 11 0,000 0,05066705 0,08506974 ! ventral spinal cord development GO:0021517 21 11 0,000 0,05066705 0,08501041 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05066705 0,08495117 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05066705 0,08489201 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,05066705 0,08483294 ! syncytium formation GO:0006949 18 11 0,000 0,05066705 0,08477394 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,05066705 0,08471503 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,05066705 0,0846562 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,05066705 0,08459745 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,05066705 0,08453879 ! lipid digestion GO:0044241 18 11 0,000 0,05066705 0,0844802 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,05066705 0,0844217 ! UV protection GO:0009650 19 11 0,000 0,05066705 0,08436328 ! adult heart development GO:0007512 14 11 0,000 0,05066705 0,08430493 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05066705 0,08424667 ! temperature homeostasis GO:0001659 17 11 0,000 0,05066705 0,08418849 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,05066705 0,08413039 ! regulation of organ growth GO:0046620 13 11 0,000 0,05066705 0,08407237 ! pigment granule localization GO:0051875 20 11 0,000 0,05066705 0,08401443 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,05066705 0,08395657 ! vasoconstriction GO:0042310 18 11 0,000 0,05066705 0,08389878 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05066705 0,08384108 ! embryonic axis specification GO:0000578 18 11 0,000 0,05066705 0,08378346 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,05066705 0,08372592 ! snRNA metabolic process GO:0016073 24 11 0,000 0,05066705 0,08366845 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05066705 0,08361106 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,05066705 0,08355376 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,05066705 0,08349653 ! zymogen activation GO:0031638 15 11 0,000 0,05066705 0,08343938 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,05066705 0,08338231 ! nucleosome positioning GO:0016584 15 11 0,000 0,05066705 0,08332531 ! regulation of isotype switching GO:0045191 22 11 0,000 0,05066705 0,0832684 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,05066705 0,08321156 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,05066705 0,0831548 ! acid secretion GO:0046717 18 11 0,000 0,05066705 0,08309811 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05066705 0,08304151 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,05066705 0,08298498 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,05066705 0,08292853 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,05066705 0,08287215 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,05066705 0,08281585 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,05066705 0,08275963 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,05066705 0,08270348 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05066705 0,08264741 ! germ cell migration GO:0008354 25 11 0,000 0,05066705 0,08259142 ! embryonic gut development GO:0048566 15 11 0,000 0,05066705 0,0825355 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,05066705 0,08247966 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,05066705 0,08242389 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,05066705 0,0823682 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,05066705 0,08231258 ! defense response to fungus GO:0050832 13 11 0,000 0,05066705 0,08225704 ! developmental induction GO:0031128 19 11 0,000 0,05066705 0,08220157 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,05066705 0,08214618 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05066705 0,08209086 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,05066705 0,08203562 ! sequestering of metal ion GO:0051238 14 11 0,000 0,05066705 0,08198045 ! lamellipodium assembly GO:0030032 20 11 0,000 0,05066705 0,08192536 ! regulation of embryonic development GO:0045995 27 11 0,000 0,05066705 0,08187034 ! nucleus localization GO:0051647 19 11 0,000 0,05066705 0,08181539 ! regulation of synapse organization GO:0050807 17 11 0,000 0,05066705 0,08176052 ! positive regulation of lymphocyte activation GO:0051251 127 77 1,000 0,05134002 0,08279094 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,05373454 0,08659431 ! protein import into nucleus GO:0006606 158 80 1,000 0,05494647 0,08848809 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,05514474 0,08874799 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,05514474 0,08868867 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,05514474 0,08862943 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,05514474 0,08857026 ! virus-host interaction GO:0019048 29 12 0,000 0,05514474 0,08851117 ! cartilage condensation GO:0001502 20 12 0,000 0,05514474 0,08845217 ! mating GO:0007618 17 12 0,000 0,05514474 0,08839324 ! protein complex disassembly GO:0043241 27 12 0,000 0,05514474 0,08833439 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05514474 0,08827562 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,05514474 0,08821692 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,05514474 0,08815831 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,05514474 0,08809977 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,05514474 0,08804131 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,05514474 0,08798292 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,05514474 0,08792462 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,05514474 0,08786639 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,05514474 0,08780824 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,05514474 0,08775017 ! drug transport GO:0015893 16 12 0,000 0,05514474 0,08769217 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,05514474 0,08763425 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,05514474 0,0875764 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,05514474 0,08751863 ! polyamine metabolic process GO:0006595 17 12 0,000 0,05514474 0,08746094 ! mitotic spindle organization GO:0007052 21 12 0,000 0,05514474 0,08740333 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,05514474 0,08734579 ! forebrain cell migration GO:0021885 21 12 0,000 0,05514474 0,08728832 ! asymmetric protein localization GO:0008105 20 12 0,000 0,05514474 0,08723093 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,05514474 0,08717362 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,05514474 0,08711638 ! entry into host cell GO:0030260 32 12 0,000 0,05514474 0,08705922 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,05514474 0,08700213 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05514474 0,08694512 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,05514474 0,08688818 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,05514474 0,08683132 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,05514474 0,08677453 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05514474 0,08671781 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,05514474 0,08666117 ! protein homotetramerization GO:0051289 21 12 0,000 0,05514474 0,0866046 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,05514474 0,08654811 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,05514474 0,08649169 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05514474 0,08643534 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,05514474 0,08637907 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,05514474 0,08632287 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05514474 0,08626674 ! fucose catabolic process GO:0019317 22 12 0,000 0,05514474 0,08621069 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,05514474 0,08615471 ! histone methylation GO:0016571 26 12 0,000 0,05514474 0,0860988 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,05514474 0,08604296 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,05514474 0,0859872 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,05514474 0,08593151 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,05514474 0,08587589 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,05514474 0,08582034 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,05514474 0,08576487 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,05514474 0,08570946 ! response to cold GO:0009409 17 12 0,000 0,05514474 0,08565413 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,05514474 0,08559887 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,05514474 0,08554368 ! digestion GO:0007586 112 81 1,000 0,05616802 0,0870749 ! cell-substrate adhesion GO:0031589 171 81 1,000 0,05616802 0,08701883 ! intracellular protein transmembrane transport GO:0065002 153 81 1,000 0,05616802 0,08696284 ! nuclear import GO:0051170 161 81 1,000 0,05616802 0,08690691 ! cellular response to hormone stimulus GO:0032870 167 82 1,000 0,05739907 0,0887546 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05960146 0,09210091 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,05960146 0,09204179 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,05960146 0,09198275 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,05960146 0,09192379 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,05960146 0,0918649 ! lipid localization GO:0010876 28 13 0,000 0,05960146 0,09180609 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,05960146 0,09174735 ! organelle fusion GO:0048284 32 13 0,000 0,05960146 0,09168869 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,05960146 0,0916301 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,05960146 0,09157159 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,05960146 0,09151315 ! endocrine pancreas development GO:0031018 22 13 0,000 0,05960146 0,09145479 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,05960146 0,0913965 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,05960146 0,09133829 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,05960146 0,09128015 ! plasma membrane organization GO:0007009 24 13 0,000 0,05960146 0,09122208 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,05960146 0,09116409 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,05960146 0,09110617 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,05960146 0,09104832 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,05960146 0,09099055 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,05960146 0,09093285 ! response to X-ray GO:0010165 25 13 0,000 0,05960146 0,09087523 ! cytokine metabolic process GO:0042107 22 13 0,000 0,05960146 0,09081768 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,05960146 0,0907602 ! exocrine system development GO:0035272 32 13 0,000 0,05960146 0,09070279 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,05960146 0,09064545 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,05960146 0,09058819 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,05960146 0,090531 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,05960146 0,09047389 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,05960146 0,09041684 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,05960146 0,09035987 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,05960146 0,09030297 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,05960146 0,09024614 ! regulation of cellular pH GO:0030641 22 13 0,000 0,05960146 0,09018938 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05960146 0,09013269 ! ribosome assembly GO:0042255 17 13 0,000 0,05960146 0,09007607 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,05960146 0,09001953 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,05960146 0,08996306 ! chromatin silencing GO:0006342 26 13 0,000 0,05960146 0,08990665 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,05960146 0,08985032 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05960146 0,08979406 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,05960146 0,08973787 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,05960146 0,08968174 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05960146 0,08962569 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,05960146 0,08956971 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,05960146 0,0895138 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,05960146 0,08945796 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,05960146 0,08940219 ! insulin secretion GO:0030073 23 13 0,000 0,05960146 0,08934649 ! actin filament polymerization GO:0030041 24 13 0,000 0,05960146 0,08929085 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,05960146 0,08923529 ! acrosome reaction GO:0007340 18 13 0,000 0,05960146 0,08917979 ! regulation of ligase activity GO:0051340 142 84 1,000 0,05988922 0,08955467 ! response to unfolded protein GO:0006986 131 85 1,000 0,0611481 0,09138033 ! positive regulation of cell activation GO:0050867 145 85 1,000 0,0611481 0,0913236 GO:0002696|positive regulation of leukocyte activation, ! amine biosynthetic process GO:0009309 138 86 1,000 0,06241602 0,0931594 ! nitrogen compound catabolic process GO:0044270 143 87 1,000 0,06369288 0,09500625 ! protein localization in nucleus GO:0034504 176 87 1,000 0,06369288 0,09494739 ! regulation of protein transport GO:0051223 154 87 1,000 0,06369288 0,09488859 GO:0070201|regulation of establishment of protein localization, ! rRNA transcription GO:0009303 25 14 0,000 0,0640373 0,09534266 ! lactation GO:0007595 26 14 0,000 0,0640373 0,0952837 ! reproductive cellular process GO:0048610 20 14 0,000 0,0640373 0,09522481 ! tRNA modification GO:0006400 20 14 0,000 0,0640373 0,095166 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,0640373 0,09510725 ! regulation of S phase GO:0033261 23 14 0,000 0,0640373 0,09504858 ! water transport GO:0006833 21 14 0,000 0,0640373 0,09498998 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,0640373 0,09493145 ! non-recombinational repair GO:0000726 25 14 0,000 0,0640373 0,094873 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,0640373 0,09481461 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,0640373 0,0947563 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,0640373 0,09469806 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,0640373 0,09463989 ! palate development GO:0060021 31 14 0,000 0,0640373 0,0945818 ! regulated secretory pathway GO:0045055 23 14 0,000 0,0640373 0,09452377 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,0640373 0,09446582 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,0640373 0,09440793 ! arginine metabolic process GO:0006525 17 14 0,000 0,0640373 0,09435012 ! regulation of heart rate GO:0002027 24 14 0,000 0,0640373 0,09429238 ! organic alcohol transport GO:0015850 29 14 0,000 0,0640373 0,09423471 ! actin cytoskeleton reorganization GO:0031532 33 14 0,000 0,0640373 0,09417711 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,0640373 0,09411958 ! embryo implantation GO:0007566 30 14 0,000 0,0640373 0,09406212 ! neutral amino acid transport GO:0015804 26 14 0,000 0,0640373 0,09400473 ! L-amino acid transport GO:0015807 30 14 0,000 0,0640373 0,09394741 ! bone mineralization GO:0030282 17 14 0,000 0,0640373 0,09389016 ! stem cell development GO:0048864 43 14 0,000 0,0640373 0,09383298 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,0640373 0,09377586 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,0640373 0,09371882 ! cerebellum development GO:0021549 21 14 0,000 0,0640373 0,09366185 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,0640373 0,09360495 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,0640373 0,09354812 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,0640373 0,09349135 ! cofactor transport GO:0051181 26 14 0,000 0,0640373 0,09343465 ! NADP metabolic process GO:0006739 24 14 0,000 0,0640373 0,09337803 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,0640373 0,09332147 ! intestinal absorption GO:0050892 25 14 0,000 0,0640373 0,09326498 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,0640373 0,09320856 ! oxygen transport GO:0015671 21 14 0,000 0,0640373 0,0931522 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,0640373 0,09309592 ! regulation of axon extension GO:0030516 37 14 0,000 0,0640373 0,0930397 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,0640373 0,09298355 ! regulation of cell morphogenesis GO:0022604 215 89 1,000 0,06627297 0,09617175 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06845237 0,0992745 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,06845237 0,09921469 ! superoxide anion generation GO:0042554 20 15 0,000 0,06845237 0,09915496 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,06845237 0,0990953 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,06845237 0,09903571 ! copper ion transport GO:0006825 20 15 0,000 0,06845237 0,0989762 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,06845237 0,09891675 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,06845237 0,09885738 ! sulfate transport GO:0008272 23 15 0,000 0,06845237 0,09879808 ! response to cAMP GO:0051591 22 15 0,000 0,06845237 0,09873884 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,06845237 0,09867968 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,06845237 0,09862059 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,06845237 0,09856158 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,06845237 0,09850263 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,06845237 0,09844375 ! response to hexose stimulus GO:0009746 22 15 0,000 0,06845237 0,09838494 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,06845237 0,0983262 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,06845237 0,09826754 ! pituitary gland development GO:0021983 29 15 0,000 0,06845237 0,09820894 ! vesicle coating GO:0006901 33 15 0,000 0,06845237 0,09815041 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,06845237 0,09809196 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,06845237 0,09803357 ! regulation of exocytosis GO:0017157 22 15 0,000 0,06845237 0,09797525 ! G1/S transition checkpoint GO:0031575 40 15 0,000 0,06845237 0,097917 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,06845237 0,09785882 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,06845237 0,09780071 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,06845237 0,09774267 ! regulation of vasodilation GO:0042312 26 15 0,000 0,06845237 0,09768469 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,06845237 0,09762679 ! histone deacetylation GO:0016575 20 15 0,000 0,06845237 0,09756895 ! mRNA splice site selection GO:0006376 38 15 0,000 0,06845237 0,09751119 ! tissue regeneration GO:0042246 26 15 0,000 0,06845237 0,09745349 ! water homeostasis GO:0030104 27 15 0,000 0,06845237 0,09739586 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06845237 0,09733829 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,06845237 0,0972808 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,06845237 0,09722337 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,06845237 0,09716601 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06845237 0,09710872 ! heme biosynthetic process GO:0006783 29 15 0,000 0,06845237 0,0970515 ! cell killing GO:0001906 29 15 0,000 0,06845237 0,09699434 ! detection of bacterium GO:0016045 18 15 0,000 0,06845237 0,09693725 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,06845237 0,09688023 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,06845237 0,09682328 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,06845237 0,09676639 ! peptide hormone processing GO:0016486 23 15 0,000 0,06845237 0,09670957 ! cofactor biosynthetic process GO:0051188 139 91 1,000 0,06888748 0,09726718 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,07284675 0,10279723 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,07284675 0,10273698 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,07284675 0,10267679 ! bone remodeling GO:0046849 27 16 0,000 0,07284675 0,10261668 ! filopodium assembly GO:0046847 32 16 0,000 0,07284675 0,10255663 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 0,000 0,07284675 0,10249666 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,07284675 0,10243675 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,07284675 0,10237692 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,07284675 0,10231715 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,07284675 0,10225746 ! startle response GO:0001964 28 16 0,000 0,07284675 0,10219783 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,07284675 0,10213828 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,07284675 0,10207879 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,07284675 0,10201937 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,07284675 0,10196002 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,07284675 0,10190075 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,07284675 0,10184154 ! protein polyubiquitination GO:0000209 34 16 0,000 0,07284675 0,10178239 ! glutamate metabolic process GO:0006536 22 16 0,000 0,07284675 0,10172332 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,07284675 0,10166432 ! response to osmotic stress GO:0006970 25 16 0,000 0,07284675 0,10160538 ! lysosomal transport GO:0007041 26 16 0,000 0,07284675 0,10154651 ! fructose metabolic process GO:0006000 25 16 0,000 0,07284675 0,10148771 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,07284675 0,10142898 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,07284675 0,10137032 ! intermediate filament-based process GO:0045103 32 16 0,000 0,07284675 0,10131172 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,07284675 0,1012532 ! negative regulation of immune response GO:0050777 35 16 0,000 0,07284675 0,10119474 ! axon cargo transport GO:0008088 43 16 0,000 0,07284675 0,10113634 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,07284675 0,10107802 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,07284675 0,10101976 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,07284675 0,10096157 ! DNA replication initiation GO:0006270 27 16 0,000 0,07284675 0,10090344 ! neuron recognition GO:0008038 35 16 0,000 0,07284675 0,10084539 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,07284675 0,1007874 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,07284675 0,10072947 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,07284675 0,10067162 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,07284675 0,10061382 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,07284675 0,1005561 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,07284675 0,10049844 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,07284675 0,10044085 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,07284675 0,10038332 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,07284675 0,10032586 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,07284675 0,10026847 ! female pregnancy GO:0007565 164 94 1,000 0,0728719 0,10024574 ! regulation of Rho protein signal transduction GO:0035023 213 95 1,000 0,07421632 0,10203684 ! mRNA transport GO:0051028 169 96 1,000 0,07556871 0,10383685 ! hormone metabolic process GO:0042445 157 97 1,000 0,07692896 0,1056456 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,07722055 0,10598554 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,07722055 0,10592511 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,07722055 0,10586476 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,07722055 0,10580447 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,07722055 0,10574425 ! signal complex assembly GO:0007172 41 17 0,000 0,07722055 0,1056841 ! endothelial cell migration GO:0043542 28 17 0,000 0,07722055 0,10562402 ! inositol metabolic process GO:0006020 28 17 0,000 0,07722055 0,105564 ! gene silencing by RNA GO:0031047 36 17 0,000 0,07722055 0,10550406 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,07722055 0,10544418 ! glial cell development GO:0021782 27 17 0,000 0,07722055 0,10538437 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,07722055 0,10532463 ! adult walking behavior GO:0007628 33 17 0,000 0,07722055 0,10526495 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,07722055 0,10520535 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,07722055 0,10514581 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,07722055 0,10508634 ! regulation of survival gene product expression GO:0045884 33 17 0,000 0,07722055 0,10502693 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,07722055 0,1049676 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,07722055 0,10490833 ! glycine metabolic process GO:0006544 28 17 0,000 0,07722055 0,10484912 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,07722055 0,10478999 ! NAD metabolic process GO:0019674 29 17 0,000 0,07722055 0,10473092 ! membrane budding GO:0006900 37 17 0,000 0,07722055 0,10467191 ! DNA integration GO:0015074 29 17 0,000 0,07722055 0,10461298 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,07722055 0,10455411 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,07722055 0,1044953 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,07722055 0,10443656 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,07722055 0,10437789 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,07722055 0,10431928 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,07722055 0,10426074 ! steroid catabolic process GO:0006706 31 17 0,000 0,07722055 0,10420227 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,07722055 0,10414386 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,07722055 0,10408552 ! gas transport GO:0015669 25 17 0,000 0,07722055 0,10402724 ! organic cation transport GO:0015695 31 17 0,000 0,07722055 0,10396902 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,07722055 0,10391088 ! microspike assembly GO:0030035 36 17 0,000 0,07722055 0,10385279 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,07722055 0,10379477 ! response to virus GO:0009615 160 98 1,000 0,07829698 0,10518287 ! carboxylic acid catabolic process GO:0046395 156 98 1,000 0,07829698 0,10512418 GO:0016054|organic acid catabolic process, ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,08157386 0,10946275 ! neuron maturation GO:0042551 42 18 0,000 0,08157386 0,10940174 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,08157386 0,10934079 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,08157386 0,10927991 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,08157386 0,10921909 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,08157386 0,10915835 ! memory GO:0007613 31 18 0,000 0,08157386 0,10909767 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,08157386 0,10903706 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,08157386 0,10897652 ! patterning of blood vessels GO:0001569 39 18 0,000 0,08157386 0,10891605 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,08157386 0,10885564 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,08157386 0,1087953 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,08157386 0,10873502 ! glutamine metabolic process GO:0006541 29 18 0,000 0,08157386 0,10867481 ! response to fungus GO:0009620 21 18 0,000 0,08157386 0,10861467 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,08157386 0,1085546 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,08157386 0,10849459 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,08157386 0,10843465 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,08157386 0,10837477 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,08157386 0,10831496 ! vitamin transport GO:0051180 27 18 0,000 0,08157386 0,10825522 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,08157386 0,10819554 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,08157386 0,10813593 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,08157386 0,10807638 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,08157386 0,1080169 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,08157386 0,10795749 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,08157386 0,10789814 ! protein secretion GO:0009306 39 19 0,000 0,08590678 0,11356688 ! positive regulation of translation GO:0045727 30 19 0,000 0,08590678 0,11350451 ! negative regulation of defense response GO:0031348 25 19 0,000 0,08590678 0,11344221 ! skin development GO:0043588 36 19 0,000 0,08590678 0,11337999 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,08590678 0,11331783 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,08590678 0,11325573 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,08590678 0,11319371 ! bile acid metabolic process GO:0008206 29 19 0,000 0,08590678 0,11313175 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,08590678 0,11306987 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,08590678 0,11300805 ! cerebral cortex development GO:0021987 36 19 0,000 0,08590678 0,11294629 ! heme metabolic process GO:0042168 36 19 0,000 0,08590678 0,11288461 ! actin filament bundle formation GO:0051017 42 19 0,000 0,08590678 0,11282299 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,08590678 0,11276144 ! peptide cross-linking GO:0018149 37 19 0,000 0,08590678 0,11269995 ! protein export from nucleus GO:0006611 36 19 0,000 0,08590678 0,11263854 ! heart process GO:0003015 30 19 0,000 0,08590678 0,11257719 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,08590678 0,1125159 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,08590678 0,11245469 ! visual learning GO:0008542 36 19 0,000 0,08590678 0,11239354 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,08590678 0,11233245 ! cell-cell junction organization GO:0045216 35 19 0,000 0,08590678 0,11227144 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,08590678 0,11221049 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,08590678 0,1121496 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,08590678 0,11208878 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,08590678 0,11202803 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,08590678 0,11196734 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,08590678 0,11190672 ! cilium assembly GO:0042384 37 19 0,000 0,08590678 0,11184617 ! peptide hormone secretion GO:0030072 31 19 0,000 0,08590678 0,11178568 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,0902194 0,11733399 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,0902194 0,1172706 ! positive regulation of ossification GO:0045778 47 20 0,000 0,0902194 0,11720728 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,0902194 0,11714403 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,0902194 0,11708084 ! cAMP metabolic process GO:0046058 36 20 0,000 0,0902194 0,11701772 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,0902194 0,11695468 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,0902194 0,1168917 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,0902194 0,11682878 ! retinoid metabolic process GO:0001523 32 20 0,000 0,0902194 0,11676594 GO:0016101|diterpenoid metabolic process, ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,0902194 0,11670316 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,0902194 0,11664045 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,0902194 0,11657781 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 0,000 0,0902194 0,11651523 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,0902194 0,11645272 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,0902194 0,11639028 ! body fluid secretion GO:0007589 31 20 0,000 0,0902194 0,11632791 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,0902194 0,1162656 ! peptide secretion GO:0002790 35 20 0,000 0,0902194 0,11620336 ! stem cell differentiation GO:0048863 53 20 0,000 0,0902194 0,11614119 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,0902194 0,11607908 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,0902194 0,11601704 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,0902194 0,11595506 ! sensory perception of pain GO:0019233 30 20 0,000 0,0902194 0,11589315 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,0902194 0,11583131 ! diencephalon development GO:0021536 34 20 0,000 0,0902194 0,11576954 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,0902194 0,11570782 GO:0006626|protein targeting to mitochondrion, ! detection of chemical stimulus GO:0009593 37 20 0,000 0,0902194 0,11564618 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,0902194 0,1155846 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,0902194 0,11552309 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,0902194 0,11546164 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,0902194 0,11540025 ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,0902194 0,11533894 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,0902194 0,11527768 ! actin filament-based movement GO:0030048 43 20 0,000 0,0902194 0,1152165 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,0902194 0,11515537 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,0902194 0,11509432 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,0902194 0,11503332 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,0902194 0,11497239 ! regulation of cell killing GO:0031341 42 21 0,000 0,09451182 0,12037874 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,09451182 0,12031504 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,09451182 0,12025142 ! hormone secretion GO:0046879 38 21 0,000 0,09451182 0,12018786 ! glycerol metabolic process GO:0006071 34 21 0,000 0,09451182 0,12012437 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,09451182 0,12006095 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,09451182 0,11999759 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,09451182 0,1199343 ! axis specification GO:0009798 38 21 0,000 0,09451182 0,11987108 ! smooth muscle contraction GO:0006939 46 21 0,000 0,09451182 0,11980792 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,09451182 0,11974483 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,09451182 0,11968181 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,09451182 0,11961885 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,09451182 0,11955596 ! cytolysis GO:0019835 24 21 0,000 0,09451182 0,11949313 ! vasodilation GO:0042311 39 21 0,000 0,09451182 0,11943037 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,09451182 0,11936768 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,09451182 0,11930505 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,09451182 0,11924249 ! collagen fibril organization GO:0030199 59 21 0,000 0,09451182 0,11918 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,09451182 0,11911756 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,09451182 0,1190552 ! negative regulation of intracellular transport GO:0032387 41 21 0,000 0,09451182 0,1189929 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,09451182 0,11893067 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,09451182 0,1188685 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,09451182 0,11880639 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,09451182 0,11874435 ! collagen catabolic process GO:0030574 28 21 0,000 0,09451182 0,11868238 ! sperm-egg recognition GO:0035036 21 21 0,000 0,09451182 0,11862047 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,09878412 0,12391794 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,09878412 0,12385336 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,09878412 0,12378885 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,09878412 0,12372441 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,09878412 0,12366004 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,09878412 0,12359574 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,09878412 0,1235315 ! keratinization GO:0031424 28 22 0,000 0,09878412 0,12346732 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,09878412 0,12340322 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,09878412 0,12333918 ! sensory perception of taste GO:0050909 28 22 0,000 0,09878412 0,12327521 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 0,000 0,09878412 0,1232113 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,09878412 0,12314746 ! vacuolar transport GO:0007034 36 22 0,000 0,09878412 0,12308369 ! lysosome organization GO:0007040 41 22 0,000 0,09878412 0,12301998 ! central nervous system neuron development GO:0021954 46 22 0,000 0,09878412 0,12295634 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,09878412 0,12289276 ! fucose metabolic process GO:0006004 39 22 0,000 0,09878412 0,12282925 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,09878412 0,12276581 GO:0060415|muscle tissue morphogenesis, ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,09878412 0,12270243 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,09878412 0,12263911 ! sarcomere organization GO:0045214 30 22 0,000 0,09878412 0,12257586 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,09878412 0,12251268 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,09878412 0,12244956 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,09878412 0,12238651 ! protein stabilization GO:0050821 39 22 0,000 0,09878412 0,12232352 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,10303641 0,12752346 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,10303641 0,1274579 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,10303641 0,1273924 ! viral genome replication GO:0019079 41 23 0,000 0,10303641 0,12732697 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,10303641 0,12726161 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,10303641 0,12719631 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,10303641 0,12713108 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,10303641 0,12706592 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,10303641 0,12700082 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,10303641 0,1269358 ! visual behavior GO:0007632 42 23 0,000 0,10303641 0,12687083 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,10303641 0,12680594 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,10303641 0,12674111 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,10303641 0,12667635 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,10303641 0,12661165 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,10303641 0,12654702 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,10303641 0,12648245 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,10303641 0,12641795 GO:0051693|actin filament capping, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,10303641 0,12635352 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,10303641 0,12628915 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,10303641 0,12622485 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,10303641 0,12616062 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,10303641 0,12609644 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,10303641 0,12603234 ! fatty acid transport GO:0015908 44 23 0,000 0,10303641 0,1259683 ! platelet activation GO:0030168 37 23 0,000 0,10303641 0,12590432 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,10303641 0,12584041 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,10303641 0,12577656 ! hormone transport GO:0009914 40 23 0,000 0,10303641 0,12571278 ! cell-cell recognition GO:0009988 25 23 0,000 0,10303641 0,12564907 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,10303641 0,12558541 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,10303641 0,12552183 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,10303641 0,1254583 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,10303641 0,12539484 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,10303641 0,12533145 ! protein import into nucleus, translocation GO:0000060 46 24 0,000 0,10726878 0,13041368 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,10726878 0,13034782 GO:0016444|somatic cell DNA recombination, ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,10726878 0,13028202 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,10726878 0,13021629 ! spinal cord development GO:0021510 47 24 0,000 0,10726878 0,13015062 ! vacuole organization GO:0007033 43 24 0,000 0,10726878 0,13008502 ! digestive system process GO:0022600 39 24 0,000 0,10726878 0,13001949 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,10726878 0,12995402 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,10726878 0,12988862 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,10726878 0,12982328 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,10726878 0,12975801 ! membrane depolarization GO:0051899 39 24 0,000 0,10726878 0,1296928 ! pentose metabolic process GO:0019321 35 24 0,000 0,10726878 0,12962767 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,10726878 0,12956259 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,10726878 0,12949758 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,10726878 0,12943264 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,10726878 0,12936776 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,10726878 0,12930295 ! regulation of amine transport GO:0051952 40 24 0,000 0,10726878 0,1292382 ! protein tetramerization GO:0051262 52 24 0,000 0,10726878 0,12917351 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,11148131 0,13417911 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,11148131 0,13411202 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,11148131 0,134045 ! phototransduction GO:0007602 33 25 0,000 0,11148131 0,13397804 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,11148131 0,13391115 GO:0006479|protein amino acid methylation, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 0,000 0,11148131 0,13384433 ! sperm motility GO:0030317 31 25 0,000 0,11148131 0,13377758 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,11148131 0,13371089 ! negative regulation of DNA replication GO:0008156 42 25 0,000 0,11148131 0,13364427 ! receptor metabolic process GO:0043112 46 25 0,000 0,11148131 0,13357771 ! response to starvation GO:0042594 42 25 0,000 0,11148131 0,13351122 ! osteoblast differentiation GO:0001649 60 25 0,000 0,11148131 0,1334448 ! coenzyme catabolic process GO:0009109 39 25 0,000 0,11148131 0,13337844 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,11148131 0,13331215 ! interaction with host GO:0051701 62 25 0,000 0,11148131 0,13324592 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,11148131 0,13317976 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 0,000 0,11148131 0,13311367 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,11148131 0,13304764 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! immunoglobulin production GO:0002377 55 25 0,000 0,11148131 0,13298168 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,11148131 0,13291578 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,11148131 0,13284995 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,11148131 0,13278418 ! cellular response to nutrient levels GO:0031669 41 25 0,000 0,11148131 0,13271848 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,11148131 0,13265284 ! neural tube closure GO:0001843 49 25 0,000 0,11148131 0,13258727 GO:0060606|tube closure, ! liver development GO:0001889 53 25 0,000 0,11148131 0,13252176 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,11567411 0,13743798 ! embryonic pattern specification GO:0009880 44 26 0,000 0,11567411 0,13737014 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,11567411 0,13730237 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,11567411 0,13723467 ! initiation of viral infection GO:0019059 57 26 0,000 0,11567411 0,13716703 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,11567411 0,13709946 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,11567411 0,13703196 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,11567411 0,13696452 ! tube lumen formation GO:0035148 50 26 0,000 0,11567411 0,13689715 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,11567411 0,13682985 ! regulation of transcription factor import into nucleus GO:0042990 54 26 0,000 0,11567411 0,13676261 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,11567411 0,13669544 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,11567411 0,13662833 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,11567411 0,13656129 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,11567411 0,13649432 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,11567411 0,13642741 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,11567411 0,13636056 ! blastocyst development GO:0001824 49 26 0,000 0,11567411 0,13629379 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,11567411 0,13622707 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,11567411 0,13616043 ! neuron fate commitment GO:0048663 48 27 0,000 0,11984726 0,14100367 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,11984726 0,14093476 ! iron ion transport GO:0006826 59 27 0,000 0,11984726 0,14086591 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,11984726 0,14079713 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,11984726 0,14072841 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,11984726 0,14065976 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,11984726 0,14059118 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,11984726 0,14052267 ! autophagy GO:0006914 41 27 0,000 0,11984726 0,14045422 ! primary neural tube formation GO:0014020 51 27 0,000 0,11984726 0,14038584 ! base-excision repair GO:0006284 41 27 0,000 0,11984726 0,14031752 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,11984726 0,14024928 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,11984726 0,1401811 ! glutathione metabolic process GO:0006749 39 27 0,000 0,11984726 0,14011298 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,11984726 0,14004493 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,11984726 0,13997695 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,12400086 0,14475792 ! circadian rhythm GO:0007623 50 28 0,000 0,12400086 0,14468771 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,12400086 0,14461758 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,12400086 0,14454751 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,12400086 0,14447751 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,12400086 0,14440758 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,12400086 0,14433772 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,12400086 0,14426792 ! synaptogenesis GO:0007416 42 28 0,000 0,12400086 0,14419819 ! lipid oxidation GO:0034440 43 28 0,000 0,12400086 0,14412853 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,12400086 0,14405894 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,12400086 0,14398941 ! translational initiation GO:0006413 65 29 0,000 0,12813499 0,14871818 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,12813499 0,14864647 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,12813499 0,14857484 ! regulation of pH GO:0006885 43 29 0,000 0,12813499 0,14850327 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,12813499 0,14843177 ! catechol metabolic process GO:0009712 54 29 0,000 0,12813499 0,14836034 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,12813499 0,14828898 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,12813499 0,14821768 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,12813499 0,14814646 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,12813499 0,1480753 ! cell fate determination GO:0001709 60 29 0,000 0,12813499 0,14800422 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,12813499 0,1479332 ! detection of light stimulus GO:0009583 38 29 0,000 0,12813499 0,14786225 ! regulation of coagulation GO:0050818 46 29 0,000 0,12813499 0,14779136 ! phenol metabolic process GO:0018958 55 30 0,000 0,13224975 0,15246425 ! zinc ion transport GO:0006829 45 30 0,000 0,13224975 0,15239123 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,13224975 0,15231828 ! regulation of innate immune response GO:0045088 51 30 0,000 0,13224975 0,1522454 ! acute-phase response GO:0006953 49 30 0,000 0,13224975 0,15217259 ! myofibril assembly GO:0030239 47 30 0,000 0,13224975 0,15209985 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,13224975 0,15202718 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,13224975 0,15195458 ! phospholipid transport GO:0015914 51 30 0,000 0,13224975 0,15188205 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,13224975 0,15180959 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,13224975 0,15173719 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,13224975 0,15166487 ! eye morphogenesis GO:0048592 60 30 0,000 0,13224975 0,15159261 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,13634522 0,15621267 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,13634522 0,15613832 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,13634522 0,15606404 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,13634522 0,15598983 GO:0009799|determination of symmetry, ! inner ear morphogenesis GO:0042472 47 31 0,000 0,13634522 0,15591569 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,13634522 0,15584162 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,13634522 0,15576762 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,13634522 0,15569369 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,13634522 0,15561983 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,13634522 0,15554604 ! peptide transport GO:0015833 55 31 0,000 0,13634522 0,15547232 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,13634522 0,15539867 ! mesoderm formation GO:0001707 69 31 0,000 0,13634522 0,1553251 ! natural killer cell activation GO:0030101 45 31 0,000 0,13634522 0,15525159 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,13634522 0,15517815 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,13634522 0,15510478 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,13634522 0,15503148 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,1404215 0,15959099 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,1404215 0,15951564 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,1404215 0,15944036 ! cholesterol transport GO:0030301 56 32 0,000 0,1404215 0,15936516 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,1404215 0,15929002 ! spliceosome assembly GO:0000245 67 32 0,000 0,1404215 0,15921495 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,1404215 0,15913996 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,1404215 0,15906503 ! response to mechanical stimulus GO:0009612 57 32 0,000 0,1404215 0,15899018 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,1404215 0,1589154 ! regulation of protein import into nucleus GO:0042306 63 32 0,000 0,1404215 0,15884068 ! muscle cell development GO:0055001 49 32 0,000 0,1404215 0,15876604 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,1404215 0,15869147 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,1404215 0,15861696 ! BMP signaling pathway GO:0030509 64 32 0,000 0,1404215 0,15854253 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,1404215 0,15846817 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,1404215 0,15839387 ! gene silencing GO:0016458 65 32 0,000 0,1404215 0,15831965 ! protein targeting to membrane GO:0006612 68 33 0,000 0,14447868 0,16281766 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,14447868 0,16274143 ! ceramide metabolic process GO:0006672 64 33 0,000 0,14447868 0,16266528 ! formation of primary germ layer GO:0001704 72 33 0,000 0,14447868 0,1625892 ! cell fate specification GO:0001708 52 33 0,000 0,14447868 0,16251318 ! sterol transport GO:0015918 57 33 0,000 0,14447868 0,16243724 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,14447868 0,16236137 ! adult locomotory behavior GO:0008344 59 33 0,000 0,14447868 0,16228557 ! negative regulation of protein transport GO:0051224 69 33 0,000 0,14447868 0,16220985 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,14447868 0,16213419 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,14851684 0,16658812 ! glial cell differentiation GO:0010001 63 34 0,000 0,14851684 0,16651049 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,14851684 0,16643294 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,14851684 0,16635545 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,14851684 0,16627804 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,14851684 0,1662007 ! mismatch repair GO:0006298 46 34 0,000 0,14851684 0,16612344 ! spermatid development GO:0007286 63 34 0,000 0,14851684 0,16604624 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,14851684 0,16596912 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,14851684 0,16589207 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 0,000 0,14851684 0,16581509 ! negative regulation of secretion GO:0051048 63 35 0,000 0,15253607 0,17022346 ! negative regulation of DNA metabolic process GO:0051053 61 35 0,000 0,15253607 0,17014455 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,15253607 0,1700657 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,15253607 0,16998693 GO:0006639|acylglycerol metabolic process, ! negative regulation of hydrolase activity GO:0051346 62 35 0,000 0,15253607 0,16990824 ! cytokine production GO:0001816 59 35 0,000 0,15253607 0,16982961 ! neural tube formation GO:0001841 67 35 0,000 0,15253607 0,16975106 ! vesicle localization GO:0051648 64 35 0,000 0,15253607 0,16967258 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,15653647 0,17404193 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,15653647 0,17396154 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,15653647 0,17388123 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,15653647 0,17380099 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,15653647 0,17372082 ! regulation of proteolysis GO:0030162 72 36 0,000 0,15653647 0,17364073 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,15653647 0,17356071 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,15653647 0,17348076 ! aerobic respiration GO:0009060 55 36 0,000 0,15653647 0,17340089 ! RNA export from nucleus GO:0006405 56 37 0,000 0,16051811 0,17772967 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,16051811 0,17764792 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,16051811 0,17756624 ! actomyosin structure organization GO:0031032 62 37 0,000 0,16051811 0,17748464 ! organic anion transport GO:0015711 68 37 0,000 0,16051811 0,17740311 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,16051811 0,17732166 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,16051811 0,17724028 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,16051811 0,17715898 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,16051811 0,17707775 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 66 37 0,000 0,16051811 0,1769966 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,16448109 0,18128333 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,16448109 0,18120032 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,16448109 0,18111739 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,16448109 0,18103454 ! lipid homeostasis GO:0055088 67 38 0,000 0,16448109 0,18095176 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,16448109 0,18086906 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,16448109 0,18078643 ! embryonic epithelial tube formation GO:0001838 72 38 0,000 0,16448109 0,18070388 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,16448109 0,18062141 ! mRNA catabolic process GO:0006402 71 39 0,000 0,16842549 0,18486849 ! learning GO:0007612 77 39 0,000 0,16842549 0,18478419 ! ear morphogenesis GO:0042471 60 39 0,000 0,16842549 0,18469997 ! organic ether metabolic process GO:0018904 55 39 0,000 0,16842549 0,18461583 ! ion transmembrane transport GO:0034220 66 39 0,000 0,16842549 0,18453176 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,16842549 0,18444776 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,16842549 0,18436385 ! RNA modification GO:0009451 57 39 0,000 0,16842549 0,18428001 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,16842549 0,18419624 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,17235141 0,18840413 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,17235141 0,18831857 ! feeding behavior GO:0007631 59 40 0,000 0,17235141 0,18823308 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,17235141 0,18814768 ! maintenance of protein location GO:0045185 91 40 0,000 0,17235141 0,18806235 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,17625891 0,19223887 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,17625891 0,19215176 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,17625891 0,19206474 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,17625891 0,19197779 ! gliogenesis GO:0042063 88 41 0,000 0,17625891 0,19189092 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,17625891 0,19180414 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,17625891 0,19171742 ! polyol metabolic process GO:0019751 66 41 0,000 0,17625891 0,19163079 ! regulation of tube size GO:0035150 71 42 0,000 0,1801481 0,1957707 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,1801481 0,19568232 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,1801481 0,19559401 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,1801481 0,19550579 ! neuron migration GO:0001764 79 42 0,000 0,1801481 0,19541764 ! regulation of protein secretion GO:0050708 71 42 0,000 0,1801481 0,19532958 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,18401906 0,19943687 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,18401906 0,19934707 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,18401906 0,19925736 ! glucose transport GO:0015758 65 43 0,000 0,18401906 0,19916772 ! neural tube development GO:0021915 77 43 0,000 0,18401906 0,19907817 ! striated muscle contraction GO:0006941 77 43 0,000 0,18401906 0,1989887 ! phagocytosis GO:0006909 90 43 0,000 0,18401906 0,1988993 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,18787186 0,20297247 ! hexose transport GO:0008645 67 44 0,000 0,18787186 0,20288137 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,18787186 0,20279035 ! double-strand break repair GO:0006302 81 44 0,000 0,18787186 0,20269942 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,18787186 0,20260856 ! JAK-STAT cascade GO:0007259 71 44 0,000 0,18787186 0,20251779 ! maintenance of location in cell GO:0051651 97 44 0,000 0,18787186 0,20242709 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,1917066 0,20646647 ! glycolysis GO:0006096 65 45 0,000 0,1917066 0,20637409 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,1917066 0,20628179 ! detection of stimulus involved in sensory perception GO:0050906 66 45 0,000 0,1917066 0,20618958 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,1917066 0,20609745 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,1917066 0,2060054 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,1917066 0,20591343 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,1917066 0,20582155 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,1917066 0,20572975 ! cell growth GO:0016049 84 45 0,000 0,1917066 0,20563802 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,19552337 0,20963869 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,19552337 0,20954531 ! endosome transport GO:0016197 108 47 0,000 0,19932223 0,2135215 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,19932223 0,21342647 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,19932223 0,21333153 ! JNK cascade GO:0007254 91 47 0,000 0,19932223 0,21323668 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,19932223 0,21314191 ! protein homooligomerization GO:0051260 76 47 0,000 0,19932223 0,21304722 ! Notch signaling pathway GO:0007219 96 48 0,000 0,20310328 0,21699223 ! morphogenesis of embryonic epithelium GO:0016331 91 48 0,000 0,20310328 0,21689592 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,20310328 0,21679969 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,20310328 0,21670355 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,20310328 0,21660749 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,20686661 0,22052328 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,20686661 0,22042562 ! regulation of ion transport GO:0043269 77 49 0,000 0,20686661 0,22032805 ! peptide metabolic process GO:0006518 76 49 0,000 0,20686661 0,22023055 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,20686661 0,22013315 ! endocrine system development GO:0035270 104 49 0,000 0,20686661 0,22003583 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,20686661 0,2199386 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,20686661 0,21984145 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,20686661 0,21974439 ! detection of abiotic stimulus GO:0009582 74 49 0,000 0,20686661 0,21964742 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,21061228 0,22352587 ! neuromuscular process GO:0050905 99 50 0,000 0,21061228 0,22342731 ! inner ear development GO:0048839 79 50 0,000 0,21061228 0,22332884 ! viral infectious cycle GO:0019058 99 51 0,000 0,21434039 0,22718193 ! excretion GO:0007588 83 51 0,000 0,21434039 0,22708189 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,21434039 0,22698194 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,21434039 0,22688208 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,21434039 0,22678231 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,22174424 0,23451281 ! RNA catabolic process GO:0006401 93 53 0,000 0,22174424 0,23440977 ! regulation of translational initiation GO:0006446 82 53 0,000 0,22174424 0,23430682 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,22174424 0,23420397 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,22174424 0,2341012 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,22174424 0,23399853 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,22174424 0,23389594 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,22542014 0,23766909 ! cell recognition GO:0008037 85 54 0,000 0,22542014 0,23756498 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,22542014 0,23746097 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,22542014 0,23735705 ! chloride transport GO:0006821 90 55 0,000 0,2290788 0,24110394 ! glucose catabolic process GO:0006007 82 55 0,000 0,2290788 0,24099851 ! regulation of protein catabolic process GO:0042176 116 55 0,000 0,2290788 0,24089318 ! gastrulation GO:0007369 112 55 0,000 0,2290788 0,24078794 ! RNA elongation GO:0006354 79 55 0,000 0,2290788 0,24068279 ! nuclear export GO:0051168 97 55 0,000 0,2290788 0,24057774 ! regulation of actin filament length GO:0030832 105 56 0,000 0,2327203 0,2442954 ! sensory perception of smell GO:0007608 80 56 0,000 0,2327203 0,24418886 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,2327203 0,24408241 ! nucleotide-excision repair GO:0006289 83 56 0,000 0,2327203 0,24397606 ! proton transport GO:0015992 94 56 0,000 0,2327203 0,24386979 ! maintenance of location GO:0051235 118 57 0,000 0,23634472 0,24756004 ! hydrogen transport GO:0006818 97 58 0,000 0,23995214 0,25122927 ! regulation of endocytosis GO:0030100 91 58 0,000 0,23995214 0,25111999 ! adult behavior GO:0030534 99 58 0,000 0,23995214 0,25101081 ! regulation of cellular component size GO:0032535 109 59 0,000 0,24354264 0,25465606 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,24354264 0,25454544 GO:0032313|regulation of Rab GTPase activity, ! integrin-mediated signaling pathway GO:0007229 135 59 0,000 0,24354264 0,25443491 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,2471163 0,25805634 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,2471163 0,25794439 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,25067319 0,26154367 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,25067319 0,2614303 ! tRNA processing GO:0008033 89 61 0,000 0,25067319 0,26131703 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,25067319 0,26120385 ! viral reproductive process GO:0022415 126 62 0,000 0,25421339 0,26477811 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,25421339 0,26466353 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,25773699 0,26821592 ! detection of external stimulus GO:0009581 91 63 0,000 0,25773699 0,26809996 ! cell redox homeostasis GO:0045454 102 64 0,000 0,26124406 0,2716306 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,26124406 0,27151326 ! single fertilization GO:0007338 75 64 0,000 0,26124406 0,27139603 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,26473467 0,27490359 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,26473467 0,27478499 ! embryonic limb morphogenesis GO:0030326 125 65 0,000 0,26473467 0,2746665 GO:0035113|embryonic appendage morphogenesis, ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,2682089 0,27815113 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,2682089 0,27803129 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,27166684 0,28149458 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,27166684 0,2813734 ! activation of MAPK activity GO:0000187 115 67 0,000 0,27166684 0,28125233 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,27166684 0,28113136 ! hexose catabolic process GO:0019320 104 67 0,000 0,27166684 0,28101049 ! positive regulation of T cell activation GO:0050870 109 67 0,000 0,27166684 0,28088973 ! activation of immune response GO:0002253 105 67 0,000 0,27166684 0,28076907 ! amino acid transport GO:0006865 125 68 0,000 0,27510854 0,28420402 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,27510854 0,28408204 ! viral reproduction GO:0016032 134 68 0,000 0,27510854 0,28396017 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,27510854 0,2838384 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 0,000 0,27510854 0,28371674 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,2785341 0,28712641 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 0,000 0,2785341 0,28700345 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,2785341 0,28688058 ! antigen processing and presentation GO:0019882 104 69 0,000 0,2785341 0,28675783 ! appendage morphogenesis GO:0035107 135 70 0,000 0,28194358 0,29014382 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 136 71 0,000 0,28533707 0,29351047 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 142 71 0,000 0,28533707 0,29338504 ! regulation of immune effector process GO:0002697 137 71 0,000 0,28533707 0,29325971 ! acute inflammatory response GO:0002526 113 72 0,000 0,28871463 0,29660435 ! carbohydrate transport GO:0008643 110 72 0,000 0,28871463 0,29647776 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 0,000 0,28871463 0,29635128 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 0,000 0,28871463 0,2962249 ! regulation of blood pressure GO:0008217 125 73 0,000 0,29207633 0,29954632 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,29207633 0,29941869 ! fertilization GO:0009566 90 73 0,000 0,29207633 0,29929117 ! transition metal ion transport GO:0000041 126 74 0,000 0,29542227 0,30259088 ! neurotransmitter transport GO:0006836 123 74 0,000 0,29542227 0,30246212 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,29542227 0,30233346 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,29542227 0,30220492 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,29875249 0,30548173 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,29875249 0,30535195 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,30206709 0,30860867 ! defense response to bacterium GO:0042742 89 76 0,000 0,30206709 0,30847768 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,30206709 0,30834681 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,30206709 0,30821604 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,30536613 0,31145015 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,30536613 0,31131818 ! positive regulation of ligase activity GO:0051351 124 77 0,000 0,30536613 0,31118633 ! blood coagulation GO:0007596 146 78 0,000 0,30864969 0,3143993 GO:0050817|coagulation, ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,30864969 0,31426625 ! protein oligomerization GO:0051259 139 78 0,000 0,30864969 0,31413331 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,31191783 0,31732529 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,31191783 0,31719117 ! activation of protein kinase activity GO:0032147 147 79 0,000 0,31191783 0,31705716 ! regulation of synaptic transmission GO:0050804 134 79 0,000 0,31191783 0,31692327 ! regulation of adenylate cyclase activity GO:0045761 156 80 0,000 0,31517063 0,3200931 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,31517063 0,31995803 ! inorganic anion transport GO:0015698 138 80 0,000 0,31517063 0,31982309 ! regulation of cAMP biosynthetic process GO:0030817 161 82 0,000 0,3216305 0,32624072 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,3216305 0,32610324 ! regulation of cyclase activity GO:0031279 159 82 0,000 0,3216305 0,32596587 ! regulation of lyase activity GO:0051339 160 83 0,000 0,32483771 0,32907769 ! regulation of cAMP metabolic process GO:0030814 168 84 0,000 0,32802986 0,33217165 ! hemostasis GO:0007599 158 84 0,000 0,32802986 0,3320319 ! regulation of transmission of nerve impulse GO:0051969 141 84 0,000 0,32802986 0,33189228 ! nucleosome assembly GO:0006334 122 85 0,000 0,33120702 0,33496599 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,33436927 0,33802204 ! chromatin assembly GO:0031497 124 86 0,000 0,33436927 0,33788008 ! alcohol catabolic process GO:0046164 130 86 0,000 0,33436927 0,33773823 ! amine transport GO:0015837 155 86 0,000 0,33436927 0,3375965 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 0,000 0,33751667 0,34063134 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cellular respiration GO:0045333 135 88 0,000 0,34064929 0,34364872 ! regulation of neurological system process GO:0031644 148 88 0,000 0,34064929 0,34350469 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,34064929 0,34336078 ! cellular defense response GO:0006968 114 89 0,000 0,3437672 0,34635841 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 0,000 0,34687048 0,34933879 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,34687048 0,34919262 ! sterol metabolic process GO:0016125 152 91 0,000 0,34995917 0,35215465 ! nucleosome organization GO:0034728 138 92 0,000 0,35303337 0,35509962 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,35303337 0,35495123 ! vitamin metabolic process GO:0006766 139 92 0,000 0,35303337 0,35480296 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 0,000 0,35609313 0,35772863 GO:0010498|proteasomal protein catabolic process, ! regulation of nucleotide metabolic process GO:0006140 182 93 0,000 0,35609313 0,35757933 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,35913852 0,36048697 ! transcription initiation GO:0006352 153 94 0,000 0,35913852 0,36033665 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,36518646 0,36625203 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! positive regulation of immune response GO:0050778 156 96 0,000 0,36518646 0,36609942 ! detection of stimulus GO:0051606 151 96 0,000 0,36518646 0,36594695 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,36818914 0,36880228 ! protein ubiquitination GO:0016567 217 97 0,000 0,36818914 0,3686488 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,37117772 0,37148652 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,37415226 0,37430783 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,37415226 0,37415226