pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6434-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 8,000 7,038E-10 1,619E-06 ! negative regulation of protein kinase activity GO:0006469 99 57 8,000 1,987E-09 2,286E-06 ! negative regulation of kinase activity GO:0033673 100 58 8,000 2,334E-09 1,79E-06 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 4,000 3,101E-09 1,783E-06 ! negative regulation of transferase activity GO:0051348 105 61 8,000 3,715E-09 1,709E-06 ! apoptotic mitochondrial changes GO:0008637 29 18 5,000 8,409E-09 3,223E-06 ! nerve growth factor processing GO:0032455 7 5 3,000 3,189E-08 1,048E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 6,000 6,257E-08 1,799E-05 ! positive regulation of MAP kinase activity GO:0043406 121 85 8,000 7,333E-08 1,874E-05 ! release of cytochrome c from mitochondria GO:0001836 23 14 4,000 1,061E-07 2,44E-05 ! response to UV GO:0009411 75 46 6,000 1,716E-07 3,589E-05 ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 1,088E-06 2,086E-04 ! interphase GO:0051325 159 88 7,000 1,299E-06 2,297E-04 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 1,67E-06 2,743E-04 ! peptidyl-amino acid modification GO:0018193 147 93 7,000 1,98E-06 3,037E-04 ! branching morphogenesis of a tube GO:0048754 72 42 5,000 1,987E-06 2,856E-04 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 2,292E-06 3,1E-04 ! response to light stimulus GO:0009416 153 96 7,000 2,52E-06 3,22E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 2,598E-06 3,145E-04 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of neuron apoptosis GO:0043523 77 47 5,000 3,917E-06 4,505E-04 ! tube morphogenesis GO:0035239 118 73 6,000 4,26E-06 4,666E-04 ! negative regulation of MAP kinase activity GO:0043407 54 28 4,000 4,702E-06 4,916E-04 ! morphogenesis of a branching structure GO:0001763 86 49 5,000 5,026E-06 5,026E-04 ! negative regulation of blood coagulation GO:0030195 19 14 3,000 5,992E-06 5,742E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 7,148E-06 6,576E-04 ! peptidyl-threonine phosphorylation GO:0018107 14 5 2,000 7,148E-06 6,323E-04 ! negative regulation of gliogenesis GO:0014014 16 5 2,000 7,148E-06 6,089E-04 GO:0045686|negative regulation of glial cell differentiation, ! peptide hormone processing GO:0016486 19 15 3,000 8,113E-06 6,664E-04 ! neutrophil chemotaxis GO:0030593 21 16 3,000 1,074E-05 8,519E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 1,395E-05 1,069E-03 ! negative regulation of coagulation GO:0050819 23 17 3,000 1,395E-05 1,035E-03 ! prostate gland development GO:0030850 9 6 2,000 1,42E-05 1,021E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 2,000 1,42E-05 9,898E-04 ! urogenital system development GO:0001655 101 61 5,000 1,825E-05 1,235E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 5,000 2,201E-05 1,446E-03 ! pigmentation GO:0043473 74 38 4,000 2,233E-05 1,426E-03 ! renal system process GO:0003014 35 19 3,000 2,24E-05 1,392E-03 ! cell cycle checkpoint GO:0000075 108 64 5,000 2,41E-05 1,459E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 2,469E-05 1,456E-03 ! fibrinolysis GO:0042730 9 7 2,000 2,469E-05 1,419E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 2,469E-05 1,385E-03 ! B cell lineage commitment GO:0002326 17 7 2,000 2,469E-05 1,352E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 2,469E-05 1,32E-03 ! peptidyl-threonine modification GO:0018210 18 7 2,000 2,469E-05 1,29E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 2,78E-05 1,421E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 3,000 3,41E-05 1,705E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 3,000 3,41E-05 1,669E-03 ! activation of protein kinase activity GO:0032147 102 69 5,000 3,713E-05 1,779E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 3,924E-05 1,842E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 3,924E-05 1,805E-03 ! middle ear morphogenesis GO:0042474 9 8 2,000 3,924E-05 1,769E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 3,924E-05 1,735E-03 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 2,000 3,924E-05 1,703E-03 GO:0007351|tripartite regional subdivision, ! regulation of gliogenesis GO:0014013 20 8 2,000 3,924E-05 1,671E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 3,924E-05 1,641E-03 ! positive regulation of phosphorylation GO:0042327 102 70 5,000 4,031E-05 1,656E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 4,138E-05 1,67E-03 GO:0010810|regulation of cell-substrate adhesion, ! regulation of blood coagulation GO:0030193 34 22 3,000 4,138E-05 1,641E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 5,000 4,733E-05 1,845E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 5,000 4,733E-05 1,814E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 4,974E-05 1,876E-03 ! negative regulation of transport GO:0051051 116 73 5,000 5,119E-05 1,899E-03 ! mitochondrion organization GO:0007005 104 73 5,000 5,119E-05 1,869E-03 ! positive regulation of cell cycle GO:0045787 77 45 4,000 5,164E-05 1,856E-03 ! response to oxygen levels GO:0070482 137 74 5,000 5,529E-05 1,956E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 5,846E-05 2,037E-03 ! blastoderm segmentation GO:0007350 11 9 2,000 5,846E-05 2,007E-03 ! anterior/posterior axis specification GO:0009948 11 9 2,000 5,846E-05 1,977E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 5,928E-05 1,976E-03 ! negative regulation of cell development GO:0010721 56 24 3,000 5,928E-05 1,948E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of JUN kinase activity GO:0043506 34 24 3,000 5,928E-05 1,92E-03 ! gland development GO:0048732 148 77 5,000 6,921E-05 2,211E-03 ! positive regulation of nuclear division GO:0051785 39 25 3,000 7,007E-05 2,208E-03 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 7,007E-05 2,178E-03 ! regulation of angiogenesis GO:0045765 94 49 4,000 7,83E-05 2,401E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 3,000 8,223E-05 2,489E-03 ! regulation of coagulation GO:0050818 39 26 3,000 8,223E-05 2,456E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 8,297E-05 2,446E-03 ! UV protection GO:0009650 14 10 2,000 8,297E-05 2,415E-03 ! embryonic axis specification GO:0000578 12 10 2,000 8,297E-05 2,385E-03 ! positive regulation of growth GO:0045927 67 50 4,000 8,636E-05 2,452E-03 ! regulation of cell cycle process GO:0010564 122 81 5,000 9,196E-05 2,579E-03 ! positive regulation of cell migration GO:0030335 92 51 4,000 9,506E-05 2,634E-03 ! negative regulation of neuron apoptosis GO:0043524 42 27 3,000 9,585E-05 2,625E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 1,133E-04 3,066E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 24 11 2,000 1,133E-04 3,031E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 1,133E-04 2,996E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 1,133E-04 2,962E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,133E-04 2,929E-03 GO:0042130|negative regulation of T cell proliferation, ! transcription initiation GO:0006352 118 85 5,000 1,203E-04 3,074E-03 ! anterior/posterior pattern formation GO:0009952 124 85 5,000 1,203E-04 3,041E-03 ! negative regulation of multicellular organismal process GO:0051241 133 85 5,000 1,203E-04 3,008E-03 ! regulation of mitosis GO:0007088 84 54 4,000 1,252E-04 3,097E-03 GO:0051783|regulation of nuclear division, ! DNA damage response, signal transduction GO:0042770 96 56 4,000 1,491E-04 3,647E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 1,491E-04 3,609E-03 ! autonomic nervous system development GO:0048483 23 12 2,000 1,501E-04 3,596E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,501E-04 3,559E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 1,622E-04 3,807E-03 ! hormone metabolic process GO:0042445 121 90 5,000 1,65E-04 3,834E-03 ! DNA damage checkpoint GO:0000077 53 31 3,000 1,671E-04 3,843E-03 ! segmentation GO:0035282 41 31 3,000 1,671E-04 3,805E-03 ! regulation of striated muscle tissue development GO:0016202 47 31 3,000 1,671E-04 3,768E-03 ! leukocyte chemotaxis GO:0030595 43 31 3,000 1,671E-04 3,731E-03 GO:0060326|cell chemotaxis, ! regulation of muscle development GO:0048634 48 32 3,000 1,896E-04 4,194E-03 ! meiosis I GO:0007127 52 32 3,000 1,896E-04 4,154E-03 ! activation of MAPK activity GO:0000187 84 59 4,000 1,912E-04 4,148E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,938E-04 4,166E-03 ! meiosis GO:0007126 96 61 4,000 2,239E-04 4,768E-03 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 4,000 2,239E-04 4,724E-03 ! regulation of response to external stimulus GO:0032101 139 96 5,000 2,35E-04 4,915E-03 ! DNA integrity checkpoint GO:0031570 57 34 3,000 2,411E-04 4,997E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 2,411E-04 4,952E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 2,418E-04 4,921E-03 ! respiratory tube development GO:0030323 99 62 4,000 2,418E-04 4,878E-03 ! meiotic cell cycle GO:0051321 97 62 4,000 2,418E-04 4,835E-03 ! negative regulation of microtubule depolymerization GO:0007026 31 14 2,000 2,451E-04 4,859E-03 GO:0031114|regulation of microtubule depolymerization, ! activation of MAPKK activity GO:0000186 21 14 2,000 2,451E-04 4,817E-03 ! epidermis morphogenesis GO:0048730 29 14 2,000 2,451E-04 4,777E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 5,000 2,779E-04 5,371E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 2,808E-04 5,381E-03 ! Ras protein signal transduction GO:0007265 162 100 5,000 2,934E-04 5,577E-03 ! regulation of caspase activity GO:0043281 97 65 4,000 3,02E-04 5,693E-03 ! regulation of MAPKKK cascade GO:0043408 101 65 4,000 3,02E-04 5,646E-03 ! positive regulation of cell size GO:0045793 20 15 2,000 3,043E-04 5,644E-03 ! skin development GO:0043588 25 15 2,000 3,043E-04 5,599E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 3,043E-04 5,555E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 3,043E-04 5,511E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 3,043E-04 5,468E-03 ! regulation of BMP signaling pathway GO:0030510 21 15 2,000 3,043E-04 5,425E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 3,043E-04 5,384E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 3,043E-04 5,343E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 2,000 3,043E-04 5,302E-03 ! cell-substrate adhesion GO:0031589 121 66 4,000 3,244E-04 5,609E-03 ! regulation of endopeptidase activity GO:0052548 99 67 4,000 3,48E-04 5,973E-03 ! patterning of blood vessels GO:0001569 24 16 2,000 3,72E-04 6,338E-03 ! mesenchymal cell development GO:0014031 64 38 3,000 3,732E-04 6,311E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 4,000 4,267E-04 7,164E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 4,488E-04 7,48E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 4,488E-04 7,426E-03 ! actin filament bundle formation GO:0051017 26 17 2,000 4,488E-04 7,373E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 4,488E-04 7,32E-03 ! phosphoinositide-mediated signaling GO:0048015 109 71 4,000 4,557E-04 7,382E-03 ! regulation of peptidase activity GO:0052547 106 72 4,000 4,862E-04 7,82E-03 ! regulation of T cell differentiation GO:0045580 59 41 3,000 5,013E-04 8,008E-03 ! regulation of JNK cascade GO:0046328 58 41 3,000 5,013E-04 7,952E-03 ! axis specification GO:0009798 26 18 2,000 5,35E-04 8,428E-03 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 2,000 5,35E-04 8,37E-03 GO:0050886|endocrine process, ! regulation of glucose import GO:0046324 21 18 2,000 5,35E-04 8,314E-03 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 2,000 5,35E-04 8,258E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 5,35E-04 8,203E-03 ! cellular component disassembly GO:0022411 64 42 3,000 5,502E-04 8,381E-03 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 3,000 5,502E-04 8,326E-03 ! embryonic skeletal system development GO:0048706 56 42 3,000 5,502E-04 8,272E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 5,517E-04 8,24E-03 ! negative regulation of growth GO:0045926 123 75 4,000 5,869E-04 8,709E-03 ! leukocyte migration GO:0050900 60 43 3,000 6,024E-04 8,882E-03 ! activation of caspase activity GO:0006919 65 43 3,000 6,024E-04 8,826E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 6,024E-04 8,77E-03 ! response to alkaloid GO:0043279 32 19 2,000 6,311E-04 9,129E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 6,311E-04 9,072E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 6,311E-04 9,015E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 6,311E-04 8,96E-03 ! regulation of endothelial cell migration GO:0010594 40 19 2,000 6,311E-04 8,905E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 6,311E-04 8,85E-03 ! negative regulation of cell migration GO:0030336 92 44 3,000 6,581E-04 9,173E-03 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 6,581E-04 9,118E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 7,172E-04 9,878E-03 ! determination of left/right symmetry GO:0007368 23 20 2,000 7,375E-04 0,01009715 ! pallium development GO:0021543 38 20 2,000 7,375E-04 0,0100374 ! positive regulation of locomotion GO:0040017 35 20 2,000 7,375E-04 9,978E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 2,000 7,375E-04 9,92E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 7,375E-04 9,862E-03 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 1,000 7,973E-04 0,01060014 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 7,973E-04 0,01053922 ! embryonic hemopoiesis GO:0035162 10 5 1,000 7,973E-04 0,010479 ! positive regulation of glycolysis GO:0045821 11 5 1,000 7,973E-04 0,01041946 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 7,973E-04 0,01036059 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 1,000 7,973E-04 0,01030239 ! epithelial cell proliferation GO:0050673 6 5 1,000 7,973E-04 0,01024483 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 7,973E-04 0,01018792 ! valine metabolic process GO:0006573 8 5 1,000 7,973E-04 0,01013163 ! peptidyl-histidine phosphorylation GO:0018106 7 5 1,000 7,973E-04 0,01007596 ! attachment of GPI anchor to protein GO:0016255 9 5 1,000 7,973E-04 0,0100209 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 7,973E-04 9,966E-03 ! forebrain morphogenesis GO:0048853 13 5 1,000 7,973E-04 9,913E-03 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 7,973E-04 9,859E-03 ! transcription termination GO:0006353 8 5 1,000 7,973E-04 9,807E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 7,973E-04 9,754E-03 ! triglyceride catabolic process GO:0019433 6 5 1,000 7,973E-04 9,703E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 7,973E-04 9,652E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 7,973E-04 9,601E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 7,973E-04 9,551E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 7,973E-04 9,502E-03 GO:0022011|myelination in the peripheral nervous system, ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 8,467E-04 0,0100379 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! determination of bilateral symmetry GO:0009855 25 21 2,000 8,548E-04 0,0100819 GO:0009799|determination of symmetry, ! regulation of chemotaxis GO:0050920 36 21 2,000 8,548E-04 0,01003046 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 8,548E-04 9,98E-03 ! cell aging GO:0007569 32 21 2,000 8,548E-04 9,929E-03 ! regulation of vasoconstriction GO:0019229 31 21 2,000 8,548E-04 9,879E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 8,548E-04 9,83E-03 ! positive regulation of caspase activity GO:0043280 72 48 3,000 9,172E-04 0,01049541 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 3,000 9,172E-04 0,01044345 ! regulation of DNA replication GO:0006275 75 48 3,000 9,172E-04 0,01039201 ! regulation of lymphocyte differentiation GO:0045619 69 48 3,000 9,172E-04 0,01034107 ! regulation of cell adhesion GO:0030155 159 83 4,000 9,318E-04 0,0104547 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 9,832E-04 0,01097746 ! regulation of behavior GO:0050795 38 22 2,000 9,832E-04 0,01092443 ! positive regulation of JUN kinase activity GO:0043507 28 22 2,000 9,832E-04 0,01087191 ! protein tetramerization GO:0051262 39 22 2,000 9,832E-04 0,01081989 ! cartilage development GO:0051216 70 49 3,000 9,918E-04 0,01086233 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 1,038E-03 0,01131077 ! regulation of membrane potential GO:0042391 128 85 4,000 1,038E-03 0,01125742 ! ear development GO:0043583 72 50 3,000 1,071E-03 0,01155949 ! cell cycle arrest GO:0007050 150 86 4,000 1,094E-03 0,01175545 ! embryonic pattern specification GO:0009880 31 23 2,000 1,123E-03 0,01201581 ! myelination GO:0042552 35 23 2,000 1,123E-03 0,01196018 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 1,123E-03 0,01190506 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 2,000 1,123E-03 0,01185045 ! positive regulation of organelle organization GO:0010638 82 51 3,000 1,154E-03 0,01211466 ! negative regulation of cell motion GO:0051271 104 51 3,000 1,154E-03 0,01205959 ! regulation of helicase activity GO:0051095 11 6 1,000 1,189E-03 0,01237288 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 1,189E-03 0,01231714 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,189E-03 0,01226191 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 1,000 1,189E-03 0,01220717 ! signal peptide processing GO:0006465 8 6 1,000 1,189E-03 0,01215291 ! activation of MAPKKK activity GO:0000185 10 6 1,000 1,189E-03 0,01209914 ! inositol phosphate-mediated signaling GO:0048016 9 6 1,000 1,189E-03 0,01204584 ! pigment granule organization GO:0048753 11 6 1,000 1,189E-03 0,01199301 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,189E-03 0,01194064 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 1,000 1,189E-03 0,01188872 ! hyperosmotic response GO:0006972 8 6 1,000 1,189E-03 0,01183725 ! ER overload response GO:0006983 7 6 1,000 1,189E-03 0,01178623 ! vascular smooth muscle contraction GO:0014829 10 6 1,000 1,189E-03 0,01173565 ! positive regulation of muscle hypertrophy GO:0014742 9 6 1,000 1,189E-03 0,0116855 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,189E-03 0,01163577 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,189E-03 0,01158647 ! glycerol ether catabolic process GO:0044269 8 6 1,000 1,189E-03 0,01153758 GO:0046464|acylglycerol catabolic process, ! male sex determination GO:0030238 9 6 1,000 1,189E-03 0,0114891 ! deoxyribonucleoside metabolic process GO:0009120 7 6 1,000 1,189E-03 0,01144103 ! astrocyte development GO:0014002 14 6 1,000 1,189E-03 0,01139336 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 1,000 1,189E-03 0,01134608 ! DNA topological change GO:0006265 8 6 1,000 1,189E-03 0,0112992 ! Schwann cell development GO:0014044 14 6 1,000 1,189E-03 0,0112527 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,189E-03 0,01120658 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 1,189E-03 0,01116084 GO:0043011|myeloid dendritic cell differentiation, ! peptidyl-histidine modification GO:0018202 9 6 1,000 1,189E-03 0,01111547 ! progesterone metabolic process GO:0042448 8 6 1,000 1,189E-03 0,01107047 ! positive regulation of smooth muscle contraction GO:0045987 9 6 1,000 1,189E-03 0,01102583 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,189E-03 0,01098155 ! protein processing GO:0016485 114 88 4,000 1,213E-03 0,01115718 ! aging GO:0007568 79 52 3,000 1,241E-03 0,01137128 ! mitochondrial membrane organization GO:0007006 39 24 2,000 1,275E-03 0,01163881 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 1,275E-03 0,0115928 ! regulation of neurogenesis GO:0050767 153 89 4,000 1,276E-03 0,0115515 ! reproductive developmental process GO:0003006 127 89 4,000 1,276E-03 0,0115062 ! skeletal system morphogenesis GO:0048705 78 53 3,000 1,333E-03 0,01197538 ! kidney development GO:0001822 90 53 3,000 1,333E-03 0,01192878 ! DNA catabolic process GO:0006308 67 54 3,000 1,43E-03 0,01274385 ! regulation of chromosome organization GO:0033044 35 25 2,000 1,44E-03 0,01278361 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,44E-03 0,01273444 ! regulation of pH GO:0006885 36 26 2,000 1,617E-03 0,01424578 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,617E-03 0,01419141 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 1,617E-03 0,01413745 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,655E-03 0,01441461 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 1,000 1,655E-03 0,01436021 GO:0016446|somatic hypermutation of immunoglobulin genes, ! neutral lipid catabolic process GO:0046461 9 7 1,000 1,655E-03 0,01430623 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,655E-03 0,01425265 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,655E-03 0,01419946 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,655E-03 0,01414668 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 1,000 1,655E-03 0,01409428 ! microtubule bundle formation GO:0001578 8 7 1,000 1,655E-03 0,01404227 ! positive regulation of heart rate GO:0010460 9 7 1,000 1,655E-03 0,01399065 ! glycerolipid catabolic process GO:0046503 9 7 1,000 1,655E-03 0,0139394 ! adrenal gland development GO:0030325 17 7 1,000 1,655E-03 0,01388853 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 1,655E-03 0,01383802 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,655E-03 0,01378789 ! phasic smooth muscle contraction GO:0014821 12 7 1,000 1,655E-03 0,01373811 ! organ growth GO:0035265 11 7 1,000 1,655E-03 0,01368869 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 1,655E-03 0,01363963 ! behavioral fear response GO:0001662 13 7 1,000 1,655E-03 0,01359092 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 1,655E-03 0,01354255 ! response to UV-B GO:0010224 11 7 1,000 1,655E-03 0,01349453 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,655E-03 0,01344684 ! response to tumor cell GO:0002347 12 7 1,000 1,655E-03 0,01339949 ! neuroblast proliferation GO:0007405 13 7 1,000 1,655E-03 0,01335248 ! diuresis GO:0030146 12 7 1,000 1,655E-03 0,01330579 GO:0030147|natriuresis, ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,655E-03 0,01325943 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 1,000 1,655E-03 0,01321339 ! protein maturation GO:0051604 129 96 4,000 1,786E-03 0,01421487 ! response to ionizing radiation GO:0010212 47 27 2,000 1,807E-03 0,01432883 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,807E-03 0,01427959 ! protein maturation by peptide bond cleavage GO:0051605 76 58 3,000 1,865E-03 0,01469012 ! lung development GO:0030324 94 59 3,000 1,987E-03 0,01559558 ! actin filament organization GO:0007015 95 59 3,000 1,987E-03 0,01554253 ! cell junction assembly GO:0034329 56 28 2,000 2,01E-03 0,01567239 ! regulation of systemic arterial blood pressure GO:0003073 47 28 2,000 2,01E-03 0,01561944 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 2,01E-03 0,01556685 ! ensheathment of neurons GO:0007272 43 28 2,000 2,01E-03 0,01551461 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 2,000 2,01E-03 0,01546272 ! regulation of heart contraction GO:0008016 91 60 3,000 2,114E-03 0,01620628 ! regulation of homeostatic process GO:0032844 105 60 3,000 2,114E-03 0,01615244 ! regulation of body fluid levels GO:0050878 154 100 4,000 2,138E-03 0,01627928 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 2,193E-03 0,0166464 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,193E-03 0,01659165 ! succinate metabolic process GO:0006105 14 8 1,000 2,193E-03 0,01653725 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,193E-03 0,0164832 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,193E-03 0,01642951 ! keratinocyte proliferation GO:0043616 12 8 1,000 2,193E-03 0,01637617 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 2,193E-03 0,01632317 ! astrocyte differentiation GO:0048708 16 8 1,000 2,193E-03 0,01627052 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 1,000 2,193E-03 0,0162182 ! melanin metabolic process GO:0006582 12 8 1,000 2,193E-03 0,01616622 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 1,000 2,193E-03 0,01611457 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 2,193E-03 0,01606325 ! regulation of muscle hypertrophy GO:0014743 11 8 1,000 2,193E-03 0,01601226 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! Schwann cell differentiation GO:0014037 17 8 1,000 2,193E-03 0,01596158 ! brain morphogenesis GO:0048854 20 8 1,000 2,193E-03 0,01591123 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,193E-03 0,0158612 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 2,193E-03 0,01581147 ! induction of an organ GO:0001759 11 8 1,000 2,193E-03 0,01576206 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,193E-03 0,01571296 ! regulation of embryonic development GO:0045995 16 8 1,000 2,193E-03 0,01566416 ! telencephalon development GO:0021537 52 29 2,000 2,227E-03 0,01586028 ! regulation of cellular response to stress GO:0080135 85 61 3,000 2,246E-03 0,01594733 ! embryonic skeletal system morphogenesis GO:0048704 42 30 2,000 2,459E-03 0,01739885 ! spindle organization GO:0007051 37 30 2,000 2,459E-03 0,01734548 ! hindbrain development GO:0030902 45 30 2,000 2,459E-03 0,01729244 ! regulation of microtubule-based process GO:0032886 58 30 2,000 2,459E-03 0,01723971 ! negative regulation of cell activation GO:0050866 44 30 2,000 2,459E-03 0,01718731 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 2,679E-03 0,01866916 ! respiratory system development GO:0060541 100 64 3,000 2,679E-03 0,01861276 ! negative regulation of secretion GO:0051048 49 31 2,000 2,704E-03 0,01873284 ! metanephros development GO:0001656 58 31 2,000 2,704E-03 0,01867659 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 2,803E-03 0,01930103 ! regulation of developmental growth GO:0048638 13 9 1,000 2,803E-03 0,01924341 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,803E-03 0,01918614 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 2,803E-03 0,01912921 GO:0010469|regulation of receptor activity, ! positive regulation of GTPase activity GO:0043547 21 9 1,000 2,803E-03 0,01907262 ! artery development GO:0060840 19 9 1,000 2,803E-03 0,01901635 GO:0048844|artery morphogenesis, ! regulation of glycolysis GO:0006110 15 9 1,000 2,803E-03 0,01896042 ! protein complex disassembly GO:0043241 17 9 1,000 2,803E-03 0,01890482 GO:0043624|cellular protein complex disassembly, ! negative regulation of striated muscle development GO:0045843 11 9 1,000 2,803E-03 0,01884954 ! T cell selection GO:0045058 18 9 1,000 2,803E-03 0,01879459 ! phosphagen metabolic process GO:0006599 12 9 1,000 2,803E-03 0,01873995 GO:0006600|creatine metabolic process, ! epithelial cell development GO:0002064 10 9 1,000 2,803E-03 0,01868563 ! positive regulation of muscle contraction GO:0045933 12 9 1,000 2,803E-03 0,01863163 ! motor axon guidance GO:0008045 14 9 1,000 2,803E-03 0,01857794 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 2,803E-03 0,01852455 ! renal water homeostasis GO:0003091 14 9 1,000 2,803E-03 0,01847147 ! oocyte differentiation GO:0009994 12 9 1,000 2,803E-03 0,0184187 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 2,803E-03 0,01836622 ! spleen development GO:0048536 15 9 1,000 2,803E-03 0,01831405 ! regulation of muscle adaptation GO:0043502 12 9 1,000 2,803E-03 0,01826216 ! response to nicotine GO:0035094 16 9 1,000 2,803E-03 0,01821058 ! localization within membrane GO:0051668 15 9 1,000 2,803E-03 0,01815928 ! reproductive structure development GO:0048608 90 65 3,000 2,834E-03 0,01831255 ! B cell activation GO:0042113 104 65 3,000 2,834E-03 0,01826126 ! monovalent inorganic cation homeostasis GO:0055067 45 32 2,000 2,964E-03 0,01904347 ! peripheral nervous system development GO:0007422 53 32 2,000 2,964E-03 0,01899042 ! regulation of protein stability GO:0031647 48 32 2,000 2,964E-03 0,01893767 ! calcium-mediated signaling GO:0019722 50 32 2,000 2,964E-03 0,01888521 ! ear morphogenesis GO:0042471 42 33 2,000 3,239E-03 0,02058021 ! cell junction organization GO:0034330 63 33 2,000 3,239E-03 0,02052352 ! carbohydrate homeostasis GO:0033500 39 33 2,000 3,239E-03 0,02046713 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 2,000 3,239E-03 0,02041106 ! negative regulation of hydrolase activity GO:0051346 50 33 2,000 3,239E-03 0,02035529 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 3,239E-03 0,02029983 ! negative regulation of muscle development GO:0048635 12 10 1,000 3,483E-03 0,02176759 ! hair follicle morphogenesis GO:0031069 17 10 1,000 3,483E-03 0,0217086 ! hippocampus development GO:0021766 19 10 1,000 3,483E-03 0,02164993 ! positive regulation of heart contraction GO:0045823 14 10 1,000 3,483E-03 0,02159157 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 3,483E-03 0,02153353 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 3,483E-03 0,0214758 ! response to X-ray GO:0010165 16 10 1,000 3,483E-03 0,02141838 ! B cell proliferation GO:0042100 14 10 1,000 3,483E-03 0,02136126 ! fear response GO:0042596 16 10 1,000 3,483E-03 0,02130445 ! negative regulation of ossification GO:0030279 19 10 1,000 3,483E-03 0,02124794 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 3,483E-03 0,02119173 ! regulation of bone resorption GO:0045124 24 10 1,000 3,483E-03 0,02113582 ! alpha-beta T cell activation GO:0046631 16 10 1,000 3,483E-03 0,0210802 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 1,000 3,483E-03 0,02102487 ! cranial nerve development GO:0021545 12 10 1,000 3,483E-03 0,02096983 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 3,483E-03 0,02091508 ! multicellular organismal water homeostasis GO:0050891 15 10 1,000 3,483E-03 0,02086061 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 3,483E-03 0,02080643 GO:0043470|regulation of carbohydrate catabolic process, ! embryonic gut development GO:0048566 11 10 1,000 3,483E-03 0,02075252 ! developmental induction GO:0031128 13 10 1,000 3,483E-03 0,0206989 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 3,529E-03 0,02092097 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 3,529E-03 0,02086719 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 3,529E-03 0,02081368 ! embryonic organ development GO:0048568 45 34 2,000 3,529E-03 0,02076045 ! regulation of action potential in neuron GO:0019228 54 35 2,000 3,835E-03 0,02250011 ! negative regulation of organelle organization GO:0010639 115 72 3,000 4,102E-03 0,02400931 ! response to reactive oxygen species GO:0000302 55 36 2,000 4,156E-03 0,0242607 ! virus-host interaction GO:0019048 17 11 1,000 4,232E-03 0,02463964 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,232E-03 0,02457742 ! detection of mechanical stimulus GO:0050982 15 11 1,000 4,232E-03 0,02451551 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 1,000 4,232E-03 0,02445392 ! regulation of intracellular pH GO:0051453 17 11 1,000 4,232E-03 0,02439263 ! vasoconstriction GO:0042310 15 11 1,000 4,232E-03 0,02433165 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 1,000 4,232E-03 0,02427097 ! T cell homeostasis GO:0043029 20 11 1,000 4,232E-03 0,0242106 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 1,000 4,232E-03 0,02415052 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! digestive tract morphogenesis GO:0048546 15 11 1,000 4,232E-03 0,02409074 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of blood pressure GO:0008217 107 73 3,000 4,31E-03 0,02447793 ! blood coagulation GO:0007596 116 75 3,000 4,747E-03 0,0268912 GO:0050817|coagulation, ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 2,000 4,846E-03 0,02738595 ! regulation of T cell proliferation GO:0042129 58 38 2,000 4,846E-03 0,02731883 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 5,048E-03 0,02838667 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 5,048E-03 0,02831743 ! cytokine biosynthetic process GO:0042089 16 12 1,000 5,048E-03 0,02824853 ! palate development GO:0060021 15 12 1,000 5,048E-03 0,02817997 ! positive regulation of cell growth GO:0030307 16 12 1,000 5,048E-03 0,02811174 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 5,048E-03 0,02804384 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 5,048E-03 0,02797626 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 1,000 5,048E-03 0,02790901 ! immunoglobulin production during immune response GO:0002381 20 12 1,000 5,048E-03 0,02784208 ! histone acetylation GO:0016573 23 12 1,000 5,048E-03 0,02777547 ! histone methylation GO:0016571 15 12 1,000 5,048E-03 0,02770918 ! gland morphogenesis GO:0022612 23 12 1,000 5,048E-03 0,02764321 ! peptidyl-lysine modification GO:0018205 18 12 1,000 5,048E-03 0,02757755 ! cAMP biosynthetic process GO:0006171 20 12 1,000 5,048E-03 0,0275122 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 5,048E-03 0,02744716 ! negative regulation of protein complex disassembly GO:0043242 67 39 2,000 5,216E-03 0,02829192 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 2,000 5,216E-03 0,02822535 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 5,216E-03 0,0281591 ! JNK cascade GO:0007254 54 39 2,000 5,216E-03 0,02809315 ! cell growth GO:0016049 61 39 2,000 5,216E-03 0,02802751 ! positive regulation of protein modification process GO:0031401 107 78 3,000 5,456E-03 0,02925177 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 2,000 5,601E-03 0,02996149 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 5,601E-03 0,02989197 ! T cell differentiation GO:0030217 65 40 2,000 5,601E-03 0,02982278 ! double-strand break repair GO:0006302 67 40 2,000 5,601E-03 0,0297539 ! B cell differentiation GO:0030183 62 40 2,000 5,601E-03 0,02968535 ! epidermal cell differentiation GO:0009913 53 40 2,000 5,601E-03 0,0296171 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 5,93E-03 0,03128447 ! cytokine metabolic process GO:0042107 17 13 1,000 5,93E-03 0,03121288 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 5,93E-03 0,03114162 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 5,93E-03 0,03107068 ! regulation of cellular pH GO:0030641 20 13 1,000 5,93E-03 0,03100006 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 5,93E-03 0,03092977 ! cellular pigmentation GO:0033059 24 13 1,000 5,93E-03 0,03085979 ! lymphocyte homeostasis GO:0002260 24 13 1,000 5,93E-03 0,03079013 ! forebrain development GO:0030900 131 80 3,000 5,966E-03 0,03090633 ! glucose transport GO:0015758 52 41 2,000 6,004E-03 0,03103263 ! hemostasis GO:0007599 125 81 3,000 6,233E-03 0,03214257 ! mitochondrial transport GO:0006839 60 42 2,000 6,424E-03 0,03305244 ! hexose transport GO:0008645 54 42 2,000 6,424E-03 0,03297866 GO:0015749|monosaccharide transport, ! regulation of gene-specific transcription GO:0032583 69 43 2,000 6,86E-03 0,03514166 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 6,86E-03 0,03506356 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 6,878E-03 0,03507633 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 6,878E-03 0,03499873 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 6,878E-03 0,03492147 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 6,878E-03 0,03484455 ! limbic system development GO:0021761 25 14 1,000 6,878E-03 0,03476797 ! startle response GO:0001964 21 14 1,000 6,878E-03 0,03469173 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 6,878E-03 0,03461581 ! cellular response to starvation GO:0009267 21 14 1,000 6,878E-03 0,03454023 ! regulation of heart rate GO:0002027 23 14 1,000 6,878E-03 0,03446498 ! negative regulation of caspase activity GO:0043154 20 14 1,000 6,878E-03 0,03439006 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 6,878E-03 0,03431546 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 1,000 6,878E-03 0,03424118 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 6,878E-03 0,03416723 ! G1/S transition checkpoint GO:0031575 33 14 1,000 6,878E-03 0,03409359 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 6,878E-03 0,03402027 ! water homeostasis GO:0030104 24 14 1,000 6,878E-03 0,03394727 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 1,000 6,878E-03 0,03387458 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 6,878E-03 0,03380219 ! peptide hormone secretion GO:0030072 23 14 1,000 6,878E-03 0,03373012 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 7,08E-03 0,03464612 ! regulation of action potential GO:0001508 71 44 2,000 7,314E-03 0,03571632 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 7,314E-03 0,03564065 ! regulation of inflammatory response GO:0050727 60 44 2,000 7,314E-03 0,0355653 ! regulation of protein localization GO:0032880 132 85 3,000 7,378E-03 0,03580158 ! positive regulation of defense response GO:0031349 59 45 2,000 7,785E-03 0,03769717 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 7,889E-03 0,03812082 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 7,889E-03 0,0380409 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 7,889E-03 0,03796132 ! response to osmotic stress GO:0006970 22 15 1,000 7,889E-03 0,03788207 ! DNA integration GO:0015074 22 15 1,000 7,889E-03 0,03780315 ! peptide secretion GO:0002790 27 15 1,000 7,889E-03 0,03772456 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 7,889E-03 0,03764629 ! peptide biosynthetic process GO:0043043 19 15 1,000 7,889E-03 0,03756835 ! defense response to virus GO:0051607 27 15 1,000 7,889E-03 0,03749073 ! metencephalon development GO:0022037 19 15 1,000 7,889E-03 0,03741342 ! negative regulation of hormone secretion GO:0046888 20 15 1,000 7,889E-03 0,03733644 ! lipid phosphorylation GO:0046834 23 15 1,000 7,889E-03 0,03725978 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 7,889E-03 0,03718342 ! regulation of muscle cell differentiation GO:0051147 24 15 1,000 7,889E-03 0,03710738 ! regulation of survival gene product expression GO:0045884 20 15 1,000 7,889E-03 0,03703166 ! cerebral cortex development GO:0021987 29 15 1,000 7,889E-03 0,03695623 ! female pregnancy GO:0007565 130 87 3,000 8E-03 0,03739663 ! regulation of protein complex disassembly GO:0043244 77 46 2,000 8,274E-03 0,03860092 ! histone modification GO:0016570 68 46 2,000 8,274E-03 0,03852278 ! regulation of T cell activation GO:0050863 128 89 3,000 8,654E-03 0,04021256 ! covalent chromatin modification GO:0016569 75 47 2,000 8,78E-03 0,04071571 ! negative regulation of immune system process GO:0002683 73 47 2,000 8,78E-03 0,04063379 ! protein secretion GO:0009306 27 16 1,000 8,963E-03 0,04139656 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 8,963E-03 0,0413136 ! hormone secretion GO:0046879 25 16 1,000 8,963E-03 0,04123097 ! protein amino acid acetylation GO:0006473 28 16 1,000 8,963E-03 0,04114867 ! glial cell development GO:0021782 24 16 1,000 8,963E-03 0,0410667 ! regulation of protein binding GO:0043393 27 16 1,000 8,963E-03 0,04098506 ! oogenesis GO:0048477 23 16 1,000 8,963E-03 0,04090374 ! G1 phase GO:0051318 27 16 1,000 8,963E-03 0,04082274 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 8,963E-03 0,04074207 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 8,963E-03 0,04066171 ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 1,000 8,963E-03 0,04058167 ! nerve development GO:0021675 18 16 1,000 8,963E-03 0,04050194 ! negative regulation of translation GO:0017148 22 16 1,000 8,963E-03 0,04042252 ! leukocyte differentiation GO:0002521 143 90 3,000 8,995E-03 0,04048451 ! cell fate commitment GO:0045165 141 92 3,000 9,701E-03 0,04357801 ! germ cell development GO:0007281 68 49 2,000 9,847E-03 0,04414741 ! regulation of cytoskeleton organization GO:0051493 154 93 3,000 0,01006709 0,04504729 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 0,01009852 0,04510018 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 1,000 0,01009852 0,04501278 GO:0019692|deoxyribose phosphate metabolic process, ! signal complex assembly GO:0007172 29 17 1,000 0,01009852 0,04492571 ! forelimb morphogenesis GO:0035136 19 17 1,000 0,01009852 0,04483898 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 0,01009852 0,04475259 ! regulation of viral genome replication GO:0045069 24 17 1,000 0,01009852 0,04466653 ! DNA duplex unwinding GO:0032508 25 17 1,000 0,01009852 0,04458079 GO:0032392|DNA geometric change, ! cellular macromolecular complex disassembly GO:0034623 29 17 1,000 0,01009852 0,04449539 ! neuromuscular junction development GO:0007528 23 17 1,000 0,01009852 0,04441031 ! body fluid secretion GO:0007589 27 17 1,000 0,01009852 0,04432556 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 0,01009852 0,04424113 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 0,01009852 0,04415702 ! negative regulation of cytoskeleton organization GO:0051494 84 50 2,000 0,01040698 0,04541945 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 0,01040698 0,04533343 ! response to oxidative stress GO:0006979 141 94 3,000 0,01044219 0,04540084 ! regulation of binding GO:0051098 151 95 3,000 0,01082623 0,04698175 ! angiogenesis GO:0001525 149 95 3,000 0,01082623 0,04689327 ! activation of phospholipase C activity GO:0007202 87 51 2,000 0,01098532 0,04749292 GO:0010863|positive regulation of phospholipase C activity, ! in utero embryonic development GO:0001701 147 96 3,000 0,01121928 0,04841339 ! positive regulation of DNA replication GO:0045740 29 18 1,000 0,01129396 0,04864441 ! cAMP metabolic process GO:0046058 33 18 1,000 0,01129396 0,04855349 ! response to retinoic acid GO:0032526 25 18 1,000 0,01129396 0,0484629 ! pigmentation during development GO:0048066 31 18 1,000 0,01129396 0,04837266 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 0,01129396 0,04828274 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 0,01129396 0,04819317 ! visual learning GO:0008542 35 18 1,000 0,01129396 0,04810392 ! somitogenesis GO:0001756 24 18 1,000 0,01129396 0,048015 ! cellular response to nutrient levels GO:0031669 27 18 1,000 0,01129396 0,04792641 ! hormone transport GO:0009914 27 18 1,000 0,01129396 0,04783815 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 0,01129396 0,04775021 ! activation of JUN kinase activity GO:0007257 23 18 1,000 0,01129396 0,0476626 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 0,01129396 0,0475753 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 0,01129396 0,04748833 ! nucleotide-excision repair GO:0006289 64 52 2,000 0,01158191 0,04861022 ! positive regulation of phospholipase activity GO:0010518 88 52 2,000 0,01158191 0,04852168 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01219685 0,05100503 ! extracellular structure organization GO:0043062 156 99 3,000 0,01245322 0,0519826 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,01254842 0,05228509 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 0,01254842 0,05219054 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 0,01254842 0,05209633 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,01254842 0,05200247 GO:0010675|regulation of cellular carbohydrate metabolic process, ! C21-steroid hormone metabolic process GO:0008207 23 19 1,000 0,01254842 0,05190894 ! regeneration GO:0031099 32 19 1,000 0,01254842 0,05181574 ! smooth muscle contraction GO:0006939 36 19 1,000 0,01254842 0,05172288 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01254842 0,05163036 ! response to vitamin A GO:0033189 26 19 1,000 0,01254842 0,05153816 ! D-ribose metabolic process GO:0006014 25 19 1,000 0,01254842 0,05144629 ! response to starvation GO:0042594 30 19 1,000 0,01254842 0,05135475 ! sex determination GO:0007530 29 19 1,000 0,01254842 0,05126353 ! somatic diversification of immunoglobulins GO:0016445 29 19 1,000 0,01254842 0,05117264 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 1,000 0,01254842 0,05108207 ! regulation of phospholipase activity GO:0010517 90 54 2,000 0,01283023 0,05213696 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01283023 0,05204501 ! positive regulation of lipase activity GO:0060193 90 54 2,000 0,01283023 0,05195338 ! response to vitamin GO:0033273 29 20 1,000 0,01386074 0,05602761 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01386074 0,05592931 ! spinal cord development GO:0021510 31 20 1,000 0,01386074 0,05583136 ! response to ethanol GO:0045471 37 20 1,000 0,01386074 0,05573376 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01386074 0,05563649 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01386074 0,05553956 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 0,01386074 0,05544297 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 0,01415257 0,05651202 ! carbohydrate transport GO:0008643 74 57 2,000 0,01484169 0,05916097 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01522979 0,06060298 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 1,000 0,01522979 0,06049831 GO:0016444|somatic cell DNA recombination, ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 0,01522979 0,060394 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 0,01522979 0,06029006 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01522979 0,06018646 ! dendrite development GO:0016358 35 21 1,000 0,01522979 0,06008323 ! visual behavior GO:0007632 39 21 1,000 0,01522979 0,05998035 ! ovarian follicle development GO:0001541 30 21 1,000 0,01522979 0,05987782 ! deoxyribonucleotide metabolic process GO:0009262 27 21 1,000 0,01522979 0,05977564 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01522979 0,0596738 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01522979 0,05957232 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 0,01522979 0,05947118 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 0,01522979 0,05937038 ! immunoglobulin production GO:0002377 33 21 1,000 0,01522979 0,05926992 GO:0002440|production of molecular mediator of immune response, ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01522979 0,0591698 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01522979 0,05907002 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 1,000 0,01522979 0,05897058 ! viral reproductive process GO:0022415 87 58 2,000 0,01554951 0,06010734 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 0,01554951 0,06000649 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01665445 0,06416288 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01665445 0,06405558 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 0,01665445 0,06394865 ! molting cycle process GO:0022404 40 22 1,000 0,01665445 0,06384207 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01665445 0,06373584 ! macromolecular complex disassembly GO:0032984 38 22 1,000 0,01665445 0,06362997 ! vasculogenesis GO:0001570 33 22 1,000 0,01665445 0,06352444 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01665445 0,06341927 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 0,01665445 0,06331444 ! ureteric bud development GO:0001657 32 22 1,000 0,01665445 0,06320997 ! membrane depolarization GO:0051899 35 22 1,000 0,01665445 0,06310583 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01665445 0,06300204 ! neural tube closure GO:0001843 33 22 1,000 0,01665445 0,06289859 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! phosphoinositide metabolic process GO:0030384 87 60 2,000 0,01702146 0,06417929 ! extracellular matrix organization GO:0030198 103 61 2,000 0,01778569 0,06695103 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01813362 0,06814921 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01813362 0,06803804 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01813362 0,06792723 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01813362 0,06781678 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01813362 0,06770669 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01813362 0,06759695 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01813362 0,06748757 ! osteoblast differentiation GO:0001649 40 23 1,000 0,01813362 0,06737854 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01813362 0,06726987 ! interaction with host GO:0051701 37 23 1,000 0,01813362 0,06716154 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01813362 0,06705357 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01813362 0,06694594 ! pentose metabolic process GO:0019321 31 23 1,000 0,01813362 0,06683865 ! spermatid development GO:0007286 33 23 1,000 0,01813362 0,06673171 ! somatic diversification of immune receptors GO:0002200 35 23 1,000 0,01813362 0,06662511 ! liver development GO:0001889 40 23 1,000 0,01813362 0,06651885 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,01937079 0,07094396 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,01937079 0,07083117 ! viral reproduction GO:0016032 92 63 2,000 0,01937079 0,07071874 ! regulation of lipase activity GO:0060191 109 63 2,000 0,01937079 0,07060667 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,0196662 0,07157003 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,0196662 0,07145697 ! neural crest cell development GO:0014032 39 24 1,000 0,0196662 0,07134426 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 0,0196662 0,0712319 ! primary neural tube formation GO:0014020 35 24 1,000 0,0196662 0,0711199 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 0,0196662 0,07100826 ! base-excision repair GO:0006284 31 24 1,000 0,0196662 0,07089696 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,0196662 0,07078601 ! appendage morphogenesis GO:0035107 93 64 2,000 0,02019171 0,07256397 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 94 65 2,000 0,02103158 0,07546432 GO:0060173|limb development, ! protein oligomerization GO:0051259 100 65 2,000 0,02103158 0,07534678 ! protein amino acid alkylation GO:0008213 39 25 1,000 0,02125113 0,07601491 GO:0006479|protein amino acid methylation, ! peptide transport GO:0015833 43 25 1,000 0,02125113 0,07589688 ! male gonad development GO:0008584 33 25 1,000 0,02125113 0,07577921 ! iron ion homeostasis GO:0055072 39 25 1,000 0,02125113 0,0756619 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 1,000 0,02125113 0,07554496 ! leukocyte proliferation GO:0070661 39 25 1,000 0,02125113 0,07542838 GO:0032943|mononuclear cell proliferation, ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,02276817 0,08068843 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,02288734 0,08098596 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 1,000 0,02288734 0,08086156 ! post-embryonic development GO:0009791 42 26 1,000 0,02288734 0,08073754 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,02288734 0,0806139 ! spermatid differentiation GO:0048515 36 26 1,000 0,02288734 0,08049064 ! GPI anchor biosynthetic process GO:0006506 37 27 1,000 0,02457379 0,08628965 ! respiratory gaseous exchange GO:0007585 47 27 1,000 0,02457379 0,08615811 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,02457379 0,08602697 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 1,000 0,02457379 0,08589623 ! response to drug GO:0042493 108 69 2,000 0,02458058 0,08578958 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 2,000 0,0255152 0,0889166 ! humoral immune response GO:0006959 86 70 2,000 0,0255152 0,08878208 ! regulation of catabolic process GO:0009894 106 70 2,000 0,0255152 0,08864797 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,02630945 0,0912696 ! GPI anchor metabolic process GO:0006505 40 28 1,000 0,02630945 0,09113215 ! triglyceride metabolic process GO:0006641 34 28 1,000 0,02630945 0,09099511 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02630945 0,09085848 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 0,02630945 0,09072226 ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,02630945 0,09058645 ! neural tube formation GO:0001841 41 28 1,000 0,02630945 0,09045104 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,02630945 0,09031604 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,02646874 0,09072743 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,02646874 0,09059241 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02809332 0,09600985 ! ovulation cycle process GO:0022602 41 29 1,000 0,02809332 0,0958674 ! mismatch repair GO:0006298 34 29 1,000 0,02809332 0,09572537 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,02809332 0,09558377 ! eye morphogenesis GO:0048592 51 29 1,000 0,02809332 0,09544258 ! tissue homeostasis GO:0001894 42 29 1,000 0,02809332 0,09530181 GO:0048871|multicellular organismal homeostasis, ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,02944269 0,09973223 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,02992437 0,10121479 ! ovulation cycle GO:0042698 43 30 1,000 0,02992437 0,10106616 ! adult locomotory behavior GO:0008344 47 30 1,000 0,02992437 0,10091797 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02992437 0,10077021 ! response to heat GO:0009408 41 30 1,000 0,02992437 0,10062289 ! response to nutrient GO:0007584 104 75 2,000 0,03047168 0,10231367 ! regulation of ligase activity GO:0051340 114 75 2,000 0,03047168 0,10216453 ! regulation of protein transport GO:0051223 114 76 2,000 0,03151945 0,10552364 GO:0070201|regulation of establishment of protein localization, ! mammary gland development GO:0030879 57 31 1,000 0,03180164 0,10631361 ! glial cell differentiation GO:0010001 55 31 1,000 0,03180164 0,10615931 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,03180164 0,10600545 ! odontogenesis GO:0042476 50 31 1,000 0,03180164 0,10585204 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,03180164 0,10569908 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03180164 0,10554655 ! cell fate specification GO:0001708 37 31 1,000 0,03180164 0,10539447 ! regulation of DNA binding GO:0051101 119 77 2,000 0,03258596 0,10783842 ! sex differentiation GO:0007548 105 77 2,000 0,03258596 0,10768348 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,03372413 0,1112848 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,03372413 0,11112537 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,03372413 0,11096639 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,03372413 0,11080787 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,03372413 0,1106498 ! cytokine production GO:0001816 44 32 1,000 0,03372413 0,11049218 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,03372413 0,110335 ! regulation of cAMP biosynthetic process GO:0030817 136 79 2,000 0,03477498 0,11361146 ! T cell activation GO:0042110 134 79 2,000 0,03477498 0,1134503 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,03569091 0,11627349 ! phosphoinositide biosynthetic process GO:0046489 47 33 1,000 0,03569091 0,11610903 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,03569091 0,11594504 ! sister chromatid segregation GO:0000819 46 33 1,000 0,03569091 0,1157815 ! female gonad development GO:0008585 49 33 1,000 0,03569091 0,11561843 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,03569091 0,11545582 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03569091 0,11529366 ! regulation of proteolysis GO:0030162 50 33 1,000 0,03569091 0,11513196 ! hormone biosynthetic process GO:0042446 45 33 1,000 0,03569091 0,11497071 ! cytokinesis GO:0000910 52 33 1,000 0,03569091 0,11480991 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 1,000 0,03569091 0,11464956 ! regulation of cAMP metabolic process GO:0030814 141 81 2,000 0,03703835 0,11881199 ! regulation of neurological system process GO:0031644 122 81 2,000 0,03703835 0,11864651 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,03703835 0,1184815 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,03770101 0,12043378 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,03770101 0,12026674 ! glycerol ether metabolic process GO:0006662 44 34 1,000 0,03770101 0,12010017 ! neuron migration GO:0001764 46 34 1,000 0,03770101 0,11993405 ! female gamete generation GO:0007292 43 34 1,000 0,03770101 0,1197684 ! ossification GO:0001503 134 82 2,000 0,03819775 0,12117908 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 2,000 0,03937556 0,12474351 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,03975351 0,12576763 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,03975351 0,12559487 ! cyclic nucleotide metabolic process GO:0009187 58 35 1,000 0,03975351 0,12542259 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,03975351 0,12525077 ! pigment metabolic process GO:0042440 61 35 1,000 0,03975351 0,12507943 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,03975351 0,12490856 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of defense response GO:0031347 117 84 2,000 0,0405717 0,12730547 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04184748 0,13112971 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 1,000 0,04184748 0,1309513 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,04184748 0,13077337 ! negative regulation of binding GO:0051100 58 36 1,000 0,04184748 0,13059593 ! organic ether metabolic process GO:0018904 46 36 1,000 0,04184748 0,13041898 ! neural tube development GO:0021915 50 36 1,000 0,04184748 0,13024249 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04184748 0,13006649 GO:0046660|female sex differentiation, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 2,000 0,04301867 0,13352624 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,04398202 0,13633241 ! learning GO:0007612 67 37 1,000 0,04398202 0,13614892 ! regulation of protein secretion GO:0050708 51 37 1,000 0,04398202 0,13596593 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,04426935 0,13667048 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,04426935 0,13648727 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04438484 0,13666016 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04438484 0,13647746 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04438484 0,13629524 ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04438484 0,13611352 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04438484 0,13593227 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04438484 0,13575151 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04438484 0,13557123 ! sleep GO:0030431 11 5 0,000 0,04438484 0,13539143 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04438484 0,1352121 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04438484 0,13503325 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04438484 0,13485487 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04438484 0,13467696 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04438484 0,13449952 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04438484 0,13432255 ! tongue development GO:0043586 6 5 0,000 0,04438484 0,13414604 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04438484 0,13397 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04438484 0,13379441 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04438484 0,13361929 ! cobalt ion transport GO:0006824 9 5 0,000 0,04438484 0,13344462 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04438484 0,13327041 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04438484 0,13309666 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04438484 0,13292336 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04438484 0,1327505 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04438484 0,1325781 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04438484 0,13240614 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04438484 0,13223463 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04438484 0,13206357 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04438484 0,13189294 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04438484 0,13172276 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04438484 0,13155301 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04438484 0,1313837 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04438484 0,13121483 ! malate metabolic process GO:0006108 7 5 0,000 0,04438484 0,13104639 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04438484 0,13087838 ! behavioral response to pain GO:0048266 7 5 0,000 0,04438484 0,1307108 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04438484 0,13054365 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04438484 0,13037693 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04438484 0,13021063 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04438484 0,13004476 ! mating behavior GO:0007617 6 5 0,000 0,04438484 0,12987931 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04438484 0,12971428 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04438484 0,12954967 ! rhythmic behavior GO:0007622 12 5 0,000 0,04438484 0,12938547 ! copulation GO:0007620 7 5 0,000 0,04438484 0,12922169 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04438484 0,12905833 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04438484 0,12889538 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04438484 0,12873283 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04438484 0,1285707 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04438484 0,12840898 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04438484 0,12824766 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04438484 0,12808675 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04438484 0,12792624 ! response to protozoan GO:0001562 9 5 0,000 0,04438484 0,12776613 ! lymph vessel development GO:0001945 7 5 0,000 0,04438484 0,12760642 ! endochondral ossification GO:0001958 12 5 0,000 0,04438484 0,12744711 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04438484 0,1272882 ! parathyroid gland development GO:0060017 8 5 0,000 0,04438484 0,12712969 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04438484 0,12697156 ! anagen GO:0042640 6 5 0,000 0,04438484 0,12681384 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04438484 0,1266565 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04438484 0,12649955 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04438484 0,12634299 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04438484 0,12618682 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04438484 0,12603103 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04438484 0,12587563 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04438484 0,12572061 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04438484 0,12556598 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04438484 0,12541172 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04438484 0,12525784 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04438484 0,12510434 ! ovulation GO:0030728 6 5 0,000 0,04438484 0,12495121 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04438484 0,12479846 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,04438484 0,12464608 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,04438484 0,12449407 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04438484 0,12434243 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04438484 0,12419117 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04438484 0,12404026 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04438484 0,12388973 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04438484 0,12373956 ! polyol catabolic process GO:0046174 7 5 0,000 0,04438484 0,12358976 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04438484 0,12344031 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04438484 0,12329123 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04438484 0,12314251 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04438484 0,12299414 ! urea metabolic process GO:0019627 6 5 0,000 0,04438484 0,12284613 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04438484 0,12269848 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04438484 0,12255119 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04438484 0,12240424 ! neutrophil activation GO:0042119 5 5 0,000 0,04438484 0,12225765 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04438484 0,12211141 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04438484 0,12196552 ! response to food GO:0032094 5 5 0,000 0,04438484 0,12181997 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04438484 0,12167478 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04438484 0,12152993 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04438484 0,12138542 ! forebrain neuron development GO:0021884 7 5 0,000 0,04438484 0,12124126 ! melanosome organization GO:0032438 7 5 0,000 0,04438484 0,12109744 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04438484 0,12095395 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04438484 0,12081081 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04438484 0,12066801 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04438484 0,12052555 GO:0009251|glucan catabolic process, ! nucleoside transport GO:0015858 6 5 0,000 0,04438484 0,12038342 ! nucleoside salvage GO:0043174 7 5 0,000 0,04438484 0,12024162 GO:0006166|purine ribonucleoside salvage, ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04438484 0,12010016 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04438484 0,11995903 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04438484 0,11981824 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04438484 0,11967777 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04438484 0,11953763 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04438484 0,11939782 ! depyrimidination GO:0045008 8 5 0,000 0,04438484 0,11925834 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04438484 0,11911918 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04438484 0,11898035 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04438484 0,11884184 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04438484 0,11870365 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04438484 0,11856578 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04438484 0,11842823 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04438484 0,11829101 ! monocyte differentiation GO:0030224 8 5 0,000 0,04438484 0,11815409 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04438484 0,1180175 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 5 5 0,000 0,04438484 0,11788122 ! response to UV-C GO:0010225 6 5 0,000 0,04438484 0,11774526 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04438484 0,11760961 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04438484 0,11747427 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04438484 0,11733924 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04438484 0,11720452 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04438484 0,11707011 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04438484 0,11693601 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04438484 0,11680222 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04438484 0,11666873 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04438484 0,11653555 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04438484 0,11640267 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04438484 0,11627009 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04438484 0,11613781 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04438484 0,11600584 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04438484 0,11587416 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04438484 0,11574279 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04438484 0,11561171 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04438484 0,11548093 ! neural tube patterning GO:0021532 6 5 0,000 0,04438484 0,11535044 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04438484 0,11522025 ! histone demethylation GO:0016577 9 5 0,000 0,04438484 0,11509035 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04438484 0,11496074 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04438484 0,11483143 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04438484 0,1147024 ! enteric nervous system development GO:0048484 8 5 0,000 0,04438484 0,11457367 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04438484 0,11444522 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04438484 0,11431706 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04438484 0,11418919 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04438484 0,11406161 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04438484 0,11393431 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04438484 0,11380729 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04438484 0,11368055 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04438484 0,1135541 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04438484 0,11342793 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04438484 0,11330204 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04438484 0,11317643 ! apical protein localization GO:0045176 6 5 0,000 0,04438484 0,11305109 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04438484 0,11292604 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04438484 0,11280126 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04438484 0,11267675 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04438484 0,11255252 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04438484 0,11242857 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04438484 0,11230488 ! glial cell migration GO:0008347 10 5 0,000 0,04438484 0,11218147 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04438484 0,11205833 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04438484 0,11193546 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04438484 0,11181286 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04438484 0,11169052 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04438484 0,11156846 ! neural plate development GO:0001840 6 5 0,000 0,04438484 0,11144666 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,04438484 0,11132512 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04438484 0,11120385 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04438484 0,11108285 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04438484 0,11096211 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04438484 0,11084163 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04438484 0,11072141 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04438484 0,11060145 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04438484 0,11048175 ! spindle assembly GO:0051225 5 5 0,000 0,04438484 0,11036231 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04438484 0,11024313 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04438484 0,1101242 ! organ regeneration GO:0031100 7 5 0,000 0,04438484 0,11000554 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04438484 0,10988712 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04438484 0,10976897 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04438484 0,10965106 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04438484 0,10953341 GO:0055081|anion homeostasis, ! gliogenesis GO:0042063 71 38 1,000 0,04615624 0,1137828 ! regulation of nucleotide metabolic process GO:0006140 150 89 2,000 0,04682469 0,11530705 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,04836925 0,11898318 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,04836925 0,11885606 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,04836925 0,11872921 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,04836925 0,11860263 ! male sex differentiation GO:0046661 53 39 1,000 0,04836925 0,11847633 ! chromatin remodeling GO:0006338 68 39 1,000 0,04836925 0,11835029 ! developmental growth GO:0048589 62 39 1,000 0,04836925 0,11822452 ! synapse organization GO:0050808 55 39 1,000 0,04836925 0,11809901 ! regulation of tube size GO:0035150 60 40 1,000 0,05062018 0,12346386 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,05062018 0,12333307 ! peptide metabolic process GO:0006518 56 40 1,000 0,05062018 0,12320256 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,05062018 0,12307233 ! glycerophospholipid metabolic process GO:0006650 130 92 2,000 0,05079133 0,12335802 ! DNA recombination GO:0006310 146 92 2,000 0,05079133 0,1232279 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,05290818 0,12822848 ! protein amino acid lipidation GO:0006497 62 41 1,000 0,05290818 0,1280935 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,05290818 0,12795881 ! biopolymer methylation GO:0043414 62 41 1,000 0,05290818 0,1278244 ! tRNA transcription GO:0009304 11 6 0,000 0,05302404 0,12796987 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05302404 0,12783573 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,05302404 0,12770187 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05302404 0,12756829 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05302404 0,12743499 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05302404 0,12730197 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05302404 0,12716922 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05302404 0,12703675 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05302404 0,12690456 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05302404 0,12677264 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05302404 0,126641 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05302404 0,12650963 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05302404 0,12637853 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05302404 0,12624771 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,05302404 0,12611715 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05302404 0,12598686 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05302404 0,12585685 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05302404 0,1257271 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05302404 0,12559761 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,05302404 0,1254684 ! neuron adhesion GO:0007158 9 6 0,000 0,05302404 0,12533945 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05302404 0,12521076 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05302404 0,12508234 ! mRNA stabilization GO:0048255 15 6 0,000 0,05302404 0,12495418 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05302404 0,12482629 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05302404 0,12469865 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05302404 0,12457128 ! opsonization GO:0008228 8 6 0,000 0,05302404 0,12444417 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05302404 0,12431731 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05302404 0,12419072 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05302404 0,12406438 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05302404 0,1239383 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05302404 0,12381247 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05302404 0,1236869 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05302404 0,12356158 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05302404 0,12343652 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05302404 0,12331171 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05302404 0,12318716 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05302404 0,12306285 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05302404 0,12293879 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05302404 0,12281499 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05302404 0,12269143 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05302404 0,12256812 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05302404 0,12244506 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05302404 0,12232225 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05302404 0,12219968 ! thymic T cell selection GO:0045061 12 6 0,000 0,05302404 0,12207736 ! protein lipoylation GO:0009249 10 6 0,000 0,05302404 0,12195528 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05302404 0,12183345 ! drug transport GO:0015893 6 6 0,000 0,05302404 0,12171186 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05302404 0,12159051 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05302404 0,12146941 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05302404 0,12134854 ! histidine metabolic process GO:0006547 6 6 0,000 0,05302404 0,12122792 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05302404 0,12110753 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05302404 0,12098739 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05302404 0,12086748 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05302404 0,12074781 ! adenohypophysis development GO:0021984 10 6 0,000 0,05302404 0,12062837 ! microtubule nucleation GO:0007020 10 6 0,000 0,05302404 0,12050917 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05302404 0,12039021 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05302404 0,12027148 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05302404 0,12015299 ! response to dietary excess GO:0002021 7 6 0,000 0,05302404 0,12003473 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05302404 0,1199167 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05302404 0,1197989 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05302404 0,11968134 ! purine salvage GO:0043101 8 6 0,000 0,05302404 0,119564 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05302404 0,1194469 ! neuron apoptosis GO:0051402 8 6 0,000 0,05302404 0,11933002 ! organic alcohol transport GO:0015850 9 6 0,000 0,05302404 0,11921338 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,05302404 0,11909696 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05302404 0,11898076 ! carnitine transport GO:0015879 8 6 0,000 0,05302404 0,1188648 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05302404 0,11874906 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05302404 0,11863354 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05302404 0,11851825 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05302404 0,11840319 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05302404 0,11828835 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05302404 0,11817372 ! parturition GO:0007567 12 6 0,000 0,05302404 0,11805933 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05302404 0,11794515 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05302404 0,11783119 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05302404 0,11771746 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05302404 0,11760394 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05302404 0,11749064 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05302404 0,11737756 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,05302404 0,1172647 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05302404 0,11715205 ! macrophage differentiation GO:0030225 10 6 0,000 0,05302404 0,11703962 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05302404 0,11692741 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05302404 0,11681541 ! interaction with symbiont GO:0051702 8 6 0,000 0,05302404 0,11670362 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05302404 0,11659205 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05302404 0,11648069 ! eating behavior GO:0042755 6 6 0,000 0,05302404 0,11636955 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05302404 0,11625861 ! response to copper ion GO:0046688 9 6 0,000 0,05302404 0,11614789 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05302404 0,11603738 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,05302404 0,11592708 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05302404 0,11581698 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05302404 0,1157071 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05302404 0,11559743 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05302404 0,11548796 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,05302404 0,1153787 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05302404 0,11526964 ! gas homeostasis GO:0033483 11 6 0,000 0,05302404 0,1151608 ! hair follicle maturation GO:0048820 7 6 0,000 0,05302404 0,11505215 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05302404 0,11494372 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05302404 0,11483548 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05302404 0,11472745 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05302404 0,11461963 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05302404 0,114512 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05302404 0,11440458 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05302404 0,11429736 ! histone ubiquitination GO:0016574 7 6 0,000 0,05302404 0,11419034 ! regulation of meiosis GO:0040020 10 6 0,000 0,05302404 0,11408352 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05302404 0,1139769 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05302404 0,11387048 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05302404 0,11376426 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05302404 0,11365823 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05302404 0,11355241 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05302404 0,11344678 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05302404 0,11334134 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05302404 0,1132361 ! receptor internalization GO:0031623 9 6 0,000 0,05302404 0,11313106 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05302404 0,11302621 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05302404 0,11292156 ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05302404 0,1128171 ! protein deubiquitination GO:0016579 8 6 0,000 0,05302404 0,11271283 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05302404 0,11260876 ! axonal fasciculation GO:0007413 9 6 0,000 0,05302404 0,11250487 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05302404 0,11240118 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05302404 0,11229768 ! midbrain development GO:0030901 6 6 0,000 0,05302404 0,11219437 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05302404 0,11209125 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05302404 0,11198832 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05302404 0,11188558 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05302404 0,11178303 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05302404 0,11168066 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05302404 0,11157849 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05302404 0,11147649 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05302404 0,11137469 ! adult feeding behavior GO:0008343 6 6 0,000 0,05302404 0,11127307 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05302404 0,11117164 ! blastocyst growth GO:0001832 15 6 0,000 0,05302404 0,11107039 ! pigment granule transport GO:0051904 12 6 0,000 0,05302404 0,11096932 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05302404 0,11086844 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05302404 0,11076774 ! catecholamine transport GO:0051937 7 6 0,000 0,05302404 0,11066723 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05302404 0,11056689 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05302404 0,11046674 ! protein prenylation GO:0018342 10 6 0,000 0,05302404 0,11036677 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05302404 0,11026698 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,05302404 0,11016737 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05302404 0,11006795 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05302404 0,1099687 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05302404 0,10986963 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,05523241 0,11434252 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,05523241 0,1142397 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,05523241 0,11413706 ! excretion GO:0007588 63 42 1,000 0,05523241 0,1140346 ! positive regulation of binding GO:0051099 59 43 1,000 0,05759203 0,1187997 ! neuromuscular process GO:0050905 79 43 1,000 0,05759203 0,11869325 ! vesicle organization GO:0016050 79 43 1,000 0,05759203 0,11858699 ! methylation GO:0032259 64 43 1,000 0,05759203 0,11848092 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,05998622 0,12329606 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,05998622 0,12318598 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06158562 0,12635765 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06158562 0,12624503 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,06158562 0,12613261 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06158562 0,12602039 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06158562 0,12590838 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06158562 0,12579656 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06158562 0,12568494 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06158562 0,12557351 ! reproductive behavior GO:0019098 12 7 0,000 0,06158562 0,12546229 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06158562 0,12535126 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06158562 0,12524043 ! oligopeptide transport GO:0006857 11 7 0,000 0,06158562 0,12512979 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06158562 0,12501935 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06158562 0,1249091 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06158562 0,12479905 ! RNA methylation GO:0001510 11 7 0,000 0,06158562 0,12468919 ! pericardium development GO:0060039 8 7 0,000 0,06158562 0,12457953 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06158562 0,12447005 ! fibril organization GO:0043206 13 7 0,000 0,06158562 0,12436077 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06158562 0,12425169 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06158562 0,12414279 ! lipoprotein transport GO:0042953 9 7 0,000 0,06158562 0,12403408 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06158562 0,12392557 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06158562 0,12381724 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06158562 0,1237091 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06158562 0,12360115 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06158562 0,12349339 ! chemosensory behavior GO:0007635 9 7 0,000 0,06158562 0,12338582 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,06158562 0,12327844 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06158562 0,12317124 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06158562 0,12306422 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06158562 0,1229574 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06158562 0,12285076 ! reflex GO:0060004 12 7 0,000 0,06158562 0,1227443 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06158562 0,12263803 GO:0045911|positive regulation of DNA recombination, ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06158562 0,12253194 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06158562 0,12242603 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06158562 0,12232031 ! spinal cord patterning GO:0021511 7 7 0,000 0,06158562 0,12221477 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,06158562 0,12210942 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06158562 0,12200424 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06158562 0,12189924 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06158562 0,12179443 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06158562 0,1216898 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06158562 0,12158534 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06158562 0,12148107 ! endosome organization GO:0007032 10 7 0,000 0,06158562 0,12137697 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06158562 0,12127305 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06158562 0,12116931 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06158562 0,12106575 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06158562 0,12096236 ! galactose metabolic process GO:0006012 10 7 0,000 0,06158562 0,12085915 ! vesicle fusion GO:0006906 15 7 0,000 0,06158562 0,12075611 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06158562 0,12065326 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,06158562 0,12055057 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06158562 0,12044806 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06158562 0,12034573 ! retinol metabolic process GO:0042572 9 7 0,000 0,06158562 0,12024357 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06158562 0,12014158 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06158562 0,12003976 ! rRNA modification GO:0000154 12 7 0,000 0,06158562 0,11993812 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06158562 0,11983665 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06158562 0,11973535 ! intermediate filament organization GO:0045109 11 7 0,000 0,06158562 0,11963422 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06158562 0,11953327 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06158562 0,11943248 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06158562 0,11933186 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06158562 0,11923142 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06158562 0,11913114 ! response to tropane GO:0014073 13 7 0,000 0,06158562 0,11903103 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06158562 0,11893108 ! melanosome localization GO:0032400 10 7 0,000 0,06158562 0,11883131 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06158562 0,1187317 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06158562 0,11863226 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06158562 0,11853299 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06158562 0,11843388 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06158562 0,11833494 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06158562 0,11823616 ! mast cell activation GO:0045576 9 7 0,000 0,06158562 0,11813755 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06158562 0,1180391 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,06158562 0,11794082 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06158562 0,1178427 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06158562 0,11774474 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,06158562 0,11764695 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06158562 0,11754931 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06158562 0,11745184 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06158562 0,11735453 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06158562 0,11725739 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06158562 0,1171604 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06158562 0,11706357 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06158562 0,11696691 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06158562 0,1168704 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06158562 0,11677405 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06158562 0,11667786 ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06158562 0,11658183 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06158562 0,11648596 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06158562 0,11639024 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06158562 0,11629468 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06158562 0,11619928 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06158562 0,11610403 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06158562 0,11600895 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06158562 0,11591401 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06158562 0,11581923 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06158562 0,11572461 ! lymph node development GO:0048535 9 7 0,000 0,06158562 0,11563014 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06158562 0,11553583 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06158562 0,11544166 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06158562 0,11534766 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06158562 0,1152538 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06158562 0,1151601 ! ATP catabolic process GO:0006200 10 7 0,000 0,06158562 0,11506655 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06158562 0,11497315 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,06158562 0,1148799 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06158562 0,11478681 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06158562 0,11469386 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06158562 0,11460107 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06158562 0,11450843 ! muscle adaptation GO:0043500 12 7 0,000 0,06158562 0,11441593 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06158562 0,11432359 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06158562 0,11423139 ! retina homeostasis GO:0001895 9 7 0,000 0,06158562 0,11413934 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06158562 0,11404744 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06158562 0,11395569 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06158562 0,11386409 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06158562 0,11377263 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06158562 0,11368132 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06158562 0,11359015 ! lipoprotein biosynthetic process GO:0042158 67 45 1,000 0,06241417 0,11502611 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,06241417 0,11493401 ! cell maturation GO:0048469 60 45 1,000 0,06241417 0,11484207 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 1,000 0,06487508 0,11927473 ! regulation of ossification GO:0030278 71 46 1,000 0,06487508 0,11917946 ! viral infectious cycle GO:0019058 71 47 1,000 0,06736818 0,12366066 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,06736818 0,12356205 ! endocrine system development GO:0035270 83 47 1,000 0,06736818 0,12346359 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,06736818 0,12336529 ! positive regulation of cyclase activity GO:0031281 87 47 1,000 0,06736818 0,12326715 ! response to temperature stimulus GO:0009266 62 48 1,000 0,06989268 0,12778471 ! heart morphogenesis GO:0003007 65 48 1,000 0,06989268 0,12768321 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,06989268 0,12758187 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,06989268 0,1274807 ! positive regulation of lyase activity GO:0051349 88 48 1,000 0,06989268 0,12737968 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,07007028 0,12760225 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,07007028 0,1275013 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,07007028 0,12740051 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,07007028 0,12729988 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,07007028 0,1271994 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,07007028 0,12709909 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,07007028 0,12699893 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,07007028 0,12689893 ! phosphate transport GO:0006817 10 8 0,000 0,07007028 0,12679909 ! N-glycan processing GO:0006491 12 8 0,000 0,07007028 0,12669941 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,07007028 0,12659988 ! UTP metabolic process GO:0046051 8 8 0,000 0,07007028 0,12650051 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,07007028 0,12640129 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,07007028 0,12630223 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,07007028 0,12620332 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,07007028 0,12610457 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,07007028 0,12600598 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,07007028 0,12590754 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,07007028 0,12580925 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,07007028 0,12571111 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,07007028 0,12561313 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,07007028 0,1255153 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,07007028 0,12541762 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,07007028 0,1253201 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,07007028 0,12522272 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,07007028 0,1251255 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,07007028 0,12502843 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,07007028 0,12493151 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,07007028 0,12483474 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,07007028 0,12473812 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,07007028 0,12464164 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,07007028 0,12454532 ! macrophage activation GO:0042116 12 8 0,000 0,07007028 0,12444915 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,07007028 0,12435312 ! multicellular organism growth GO:0035264 14 8 0,000 0,07007028 0,12425724 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,07007028 0,12416151 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,07007028 0,12406593 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,07007028 0,1239705 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,07007028 0,12387521 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,07007028 0,12378007 ! ruffle organization GO:0031529 11 8 0,000 0,07007028 0,12368507 ! osteoblast development GO:0002076 13 8 0,000 0,07007028 0,12359022 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,07007028 0,12349551 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,07007028 0,12340095 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,07007028 0,12330654 ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,07007028 0,12321227 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,07007028 0,12311814 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,07007028 0,12302416 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,07007028 0,12293032 ! oligodendrocyte development GO:0014003 8 8 0,000 0,07007028 0,12283662 ! segment specification GO:0007379 10 8 0,000 0,07007028 0,12274307 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,07007028 0,12264965 ! cellular extravasation GO:0045123 11 8 0,000 0,07007028 0,12255638 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,07007028 0,12246326 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,07007028 0,12237027 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,07007028 0,12227742 ! snRNA metabolic process GO:0016073 10 8 0,000 0,07007028 0,12218472 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,07007028 0,12209216 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,07007028 0,12199973 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,07007028 0,12190745 ! nucleosome disassembly GO:0006337 12 8 0,000 0,07007028 0,1218153 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,07007028 0,1217233 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,07007028 0,12163143 ! icosanoid secretion GO:0032309 12 8 0,000 0,07007028 0,1215397 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,07007028 0,12144811 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,07007028 0,12135666 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,07007028 0,12126535 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,07007028 0,12117417 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,07007028 0,12108313 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,07007028 0,12099223 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,07007028 0,12090146 ! sterol catabolic process GO:0016127 9 8 0,000 0,07007028 0,12081083 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,07007028 0,12072033 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,07007028 0,12062997 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,07007028 0,12053975 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,07007028 0,12044966 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,07007028 0,12035971 ! prophase GO:0051324 11 8 0,000 0,07007028 0,12026988 ! S phase GO:0051320 8 8 0,000 0,07007028 0,1201802 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,07007028 0,12009064 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,07007028 0,12000123 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,07007028 0,11991194 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,07007028 0,11982278 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,07007028 0,11973376 ! hormone catabolic process GO:0042447 13 8 0,000 0,07007028 0,11964487 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,07007028 0,11955612 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,07007028 0,11946749 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,07007028 0,119379 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,07007028 0,11929063 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,07007028 0,1192024 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,07007028 0,1191143 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,07007028 0,11902633 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,07007028 0,11893848 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,07007028 0,11885077 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,07007028 0,11876319 ! lamellipodium assembly GO:0030032 9 8 0,000 0,07007028 0,11867573 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,07007028 0,11858841 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,07007028 0,11850121 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,07007028 0,11841414 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 1,000 0,07244782 0,12234214 ! RNA elongation GO:0006354 62 49 1,000 0,07244782 0,12225238 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,07244782 0,12216275 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,07244782 0,12207325 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,07503286 0,12633644 ! lipid modification GO:0030258 73 50 1,000 0,07503286 0,12624402 ! positive regulation of secretion GO:0051047 71 51 1,000 0,07764704 0,13054693 ! muscle fiber development GO:0048747 74 51 1,000 0,07764704 0,13045157 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,07764704 0,13035635 ! adult behavior GO:0030534 80 51 1,000 0,07764704 0,13026127 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07847871 0,13156052 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,07847871 0,1314647 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07847871 0,13136902 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07847871 0,13127348 ! CTP metabolic process GO:0046036 9 9 0,000 0,07847871 0,13117808 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,07847871 0,13108281 ! GTP metabolic process GO:0046039 9 9 0,000 0,07847871 0,13098769 ! elastic fiber assembly GO:0048251 13 9 0,000 0,07847871 0,1308927 ! social behavior GO:0035176 14 9 0,000 0,07847871 0,13079785 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,07847871 0,13070314 ! regulation of histone modification GO:0031056 11 9 0,000 0,07847871 0,13060856 ! response to pain GO:0048265 16 9 0,000 0,07847871 0,13051412 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,07847871 0,13041982 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,07847871 0,13032566 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,07847871 0,13023163 ! lung alveolus development GO:0048286 17 9 0,000 0,07847871 0,13013773 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07847871 0,13004397 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07847871 0,12995035 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,07847871 0,12985686 ! ventral spinal cord development GO:0021517 11 9 0,000 0,07847871 0,1297635 ! protein targeting to ER GO:0045047 19 9 0,000 0,07847871 0,12967028 ! endoderm development GO:0007492 12 9 0,000 0,07847871 0,1295772 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07847871 0,12948424 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07847871 0,12939142 ! arginine catabolic process GO:0006527 10 9 0,000 0,07847871 0,12929873 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,07847871 0,12920618 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,07847871 0,12911376 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,07847871 0,12902147 ! V(D)J recombination GO:0033151 12 9 0,000 0,07847871 0,12892931 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,07847871 0,12883728 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07847871 0,12874539 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,07847871 0,12865362 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07847871 0,12856199 ! mannose metabolic process GO:0006013 9 9 0,000 0,07847871 0,12847049 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,07847871 0,12837911 ! receptor clustering GO:0043113 15 9 0,000 0,07847871 0,12828787 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07847871 0,12819676 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07847871 0,12810577 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07847871 0,12801492 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07847871 0,12792419 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,07847871 0,12783359 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07847871 0,12774312 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,07847871 0,12765278 ! DNA ligation GO:0006266 14 9 0,000 0,07847871 0,12756257 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07847871 0,12747248 ! response to amine stimulus GO:0014075 13 9 0,000 0,07847871 0,12738252 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07847871 0,12729269 ! erythrocyte development GO:0048821 11 9 0,000 0,07847871 0,12720298 ! postreplication repair GO:0006301 11 9 0,000 0,07847871 0,1271134 ! mRNA cleavage GO:0006379 13 9 0,000 0,07847871 0,12702395 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,07847871 0,12693462 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,07847871 0,12684542 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,07847871 0,12675634 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07847871 0,12666739 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,07847871 0,12657856 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07847871 0,12648986 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,07847871 0,12640128 ! acid secretion GO:0046717 14 9 0,000 0,07847871 0,12631283 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07847871 0,1262245 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07847871 0,12613629 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07847871 0,12604821 ! purine base metabolic process GO:0006144 18 9 0,000 0,07847871 0,12596025 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07847871 0,12587241 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,07847871 0,12578469 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07847871 0,1256971 ! detection of calcium ion GO:0005513 13 9 0,000 0,07847871 0,12560963 ! blastocyst formation GO:0001825 12 9 0,000 0,07847871 0,12552228 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07847871 0,12543505 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07847871 0,12534794 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07847871 0,12526095 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07847871 0,12517409 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07847871 0,12508734 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,07847871 0,12500072 ! prepulse inhibition GO:0060134 14 9 0,000 0,07847871 0,12491421 ! embryonic placenta development GO:0001892 12 9 0,000 0,07847871 0,12482782 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,07847871 0,12474156 ! insulin secretion GO:0030073 17 9 0,000 0,07847871 0,12465541 ! sequestering of metal ion GO:0051238 11 9 0,000 0,07847871 0,12456938 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07847871 0,12448347 ! nucleus localization GO:0051647 15 9 0,000 0,07847871 0,12439768 ! regulation of synapse organization GO:0050807 12 9 0,000 0,07847871 0,12431201 ! establishment of organelle localization GO:0051656 85 52 1,000 0,08028965 0,12709304 ! glycerophospholipid biosynthetic process GO:0046474 75 53 1,000 0,08295995 0,13122964 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,08565725 0,13540321 ! detection of external stimulus GO:0009581 66 54 1,000 0,08565725 0,13531022 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,08681159 0,13703957 ! neuron fate specification GO:0048665 11 10 0,000 0,08681159 0,13694558 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,08681159 0,13685171 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,08681159 0,13675798 ! thyroid gland development GO:0030878 19 10 0,000 0,08681159 0,13666437 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,08681159 0,1365709 ! synapsis GO:0007129 13 10 0,000 0,08681159 0,13647755 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,08681159 0,13638432 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,08681159 0,13629123 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,08681159 0,13619826 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,08681159 0,13610542 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,08681159 0,1360127 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,08681159 0,13592012 ! androgen metabolic process GO:0008209 13 10 0,000 0,08681159 0,13582765 ! phospholipid efflux GO:0033700 16 10 0,000 0,08681159 0,13573532 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,08681159 0,1356431 ! blood vessel remodeling GO:0001974 21 10 0,000 0,08681159 0,13555102 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,08681159 0,13545906 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,08681159 0,13536722 ! pathogenesis GO:0009405 13 10 0,000 0,08681159 0,13527551 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,08681159 0,13518392 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,08681159 0,13509246 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,08681159 0,13500112 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,08681159 0,1349099 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,08681159 0,13481881 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,08681159 0,13472783 ! melanocyte differentiation GO:0030318 15 10 0,000 0,08681159 0,13463699 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,08681159 0,13454626 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,08681159 0,13445566 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,08681159 0,13436518 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,08681159 0,13427482 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,08681159 0,13418458 ! forebrain cell migration GO:0021885 17 10 0,000 0,08681159 0,13409446 ! lipid digestion GO:0044241 15 10 0,000 0,08681159 0,13400446 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,08681159 0,13391459 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,08681159 0,13382483 ! entry into host cell GO:0030260 20 10 0,000 0,08681159 0,1337352 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,08681159 0,13364568 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,08681159 0,13355629 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,08681159 0,13346701 ! regulation of organ growth GO:0046620 11 10 0,000 0,08681159 0,13337786 ! response to dsRNA GO:0043331 18 10 0,000 0,08681159 0,13328882 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,08681159 0,1331999 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,08681159 0,1331111 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,08681159 0,13302242 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,08681159 0,13293386 ! fucose catabolic process GO:0019317 16 10 0,000 0,08681159 0,13284541 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,08681159 0,13275708 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,08681159 0,13266887 ! protein sumoylation GO:0016925 12 10 0,000 0,08681159 0,13258078 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,08681159 0,1324928 ! zymogen activation GO:0031638 14 10 0,000 0,08681159 0,13240494 ! salivary gland development GO:0007431 22 10 0,000 0,08681159 0,1323172 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,08681159 0,13222957 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,08681159 0,13214206 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,08681159 0,13205466 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,08681159 0,13196738 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,08681159 0,13188022 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,08681159 0,13179317 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,08681159 0,13170623 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,08681159 0,13161941 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,08681159 0,13153271 ! detection of bacterium GO:0016045 10 10 0,000 0,08681159 0,13144612 ! activation of innate immune response GO:0002218 10 10 0,000 0,08681159 0,13135964 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,08681159 0,13127327 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,08681159 0,13118702 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,08681159 0,13110089 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,08681159 0,13101486 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,08681159 0,13092895 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,08681159 0,13084315 ! nucleoside metabolic process GO:0009116 69 55 1,000 0,08838084 0,13312111 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,09113004 0,13717217 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,09390416 0,14125544 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,09390416 0,14116311 ! camera-type eye development GO:0043010 88 57 1,000 0,09390416 0,14107091 ! secondary metabolic process GO:0019748 84 57 1,000 0,09390416 0,14097883 ! developmental maturation GO:0021700 75 57 1,000 0,09390416 0,14088686 ! gonad development GO:0008406 79 57 1,000 0,09390416 0,14079502 ! rRNA transcription GO:0009303 17 11 0,000 0,09506959 0,14244954 ! respiratory burst GO:0045730 14 11 0,000 0,09506959 0,1423568 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,09506959 0,14226418 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,09506959 0,14217168 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,09506959 0,1420793 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,09506959 0,14198705 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,09506959 0,14189491 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,09506959 0,14180289 ! RNA polyadenylation GO:0043631 19 11 0,000 0,09506959 0,14171098 ! mating GO:0007618 14 11 0,000 0,09506959 0,1416192 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,09506959 0,14152754 ! T cell proliferation GO:0042098 20 11 0,000 0,09506959 0,141436 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,09506959 0,14134457 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,09506959 0,14125326 ! bone resorption GO:0045453 16 11 0,000 0,09506959 0,14116207 ! regulated secretory pathway GO:0045055 14 11 0,000 0,09506959 0,141071 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,09506959 0,14098004 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,09506959 0,14088921 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,09506959 0,14079849 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,09506959 0,14070788 ! syncytium formation GO:0006949 15 11 0,000 0,09506959 0,1406174 ! plasma membrane organization GO:0007009 18 11 0,000 0,09506959 0,14052702 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,09506959 0,14043677 ! mitotic spindle organization GO:0007052 15 11 0,000 0,09506959 0,14034663 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,09506959 0,14025661 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,09506959 0,1401667 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,09506959 0,14007691 ! adult heart development GO:0007512 11 11 0,000 0,09506959 0,13998723 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,09506959 0,13989766 ! temperature homeostasis GO:0001659 16 11 0,000 0,09506959 0,13980822 ! L-glutamate transport GO:0015813 16 11 0,000 0,09506959 0,13971888 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,09506959 0,13962966 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,09506959 0,13954055 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,09506959 0,13945156 ! stem cell development GO:0048864 29 11 0,000 0,09506959 0,13936268 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,09506959 0,13927392 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,09506959 0,13918526 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,09506959 0,13909672 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,09506959 0,1390083 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,09506959 0,13891998 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,09506959 0,13883178 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,09506959 0,13874369 ! ribosome assembly GO:0042255 13 11 0,000 0,09506959 0,13865571 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,09506959 0,13856784 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,09506959 0,13848008 ! chromatin silencing GO:0006342 19 11 0,000 0,09506959 0,13839244 ! nucleosome positioning GO:0016584 13 11 0,000 0,09506959 0,1383049 ! regulation of isotype switching GO:0045191 19 11 0,000 0,09506959 0,13821748 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,09506959 0,13813016 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,09506959 0,13804296 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,09506959 0,13795587 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,09506959 0,13786888 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,09506959 0,13778201 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,09506959 0,13769525 ! oxygen transport GO:0015671 15 11 0,000 0,09506959 0,13760859 ! male genitalia development GO:0030539 13 11 0,000 0,09506959 0,13752204 ! cholesterol efflux GO:0033344 19 11 0,000 0,09506959 0,13743561 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,09506959 0,13734928 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,09506959 0,13726306 ! germ cell migration GO:0008354 18 11 0,000 0,09506959 0,13717694 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,09506959 0,13709094 ! defense response to fungus GO:0050832 12 11 0,000 0,09506959 0,13700504 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,09506959 0,13691925 ! lysogeny GO:0030069 18 11 0,000 0,09506959 0,13683357 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,09506959 0,136748 ! acrosome reaction GO:0007340 13 11 0,000 0,09506959 0,13666253 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,09506959 0,13657717 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,09952452 0,14288789 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,09952452 0,14279875 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,09952452 0,14270972 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,10236945 0,14669766 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 1,000 0,10236945 0,14660631 ! lactation GO:0007595 20 12 0,000 0,10325338 0,14778019 ! reproductive cellular process GO:0048610 14 12 0,000 0,10325338 0,14768829 ! tRNA modification GO:0006400 14 12 0,000 0,10325338 0,1475965 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,10325338 0,14750482 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,10325338 0,14741326 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,10325338 0,14732182 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,10325338 0,14723048 ! non-recombinational repair GO:0000726 19 12 0,000 0,10325338 0,14713926 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,10325338 0,14704815 ! peroxisomal transport GO:0043574 21 12 0,000 0,10325338 0,14695716 ! cartilage condensation GO:0001502 18 12 0,000 0,10325338 0,14686628 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,10325338 0,14677551 ! heart looping GO:0001947 15 12 0,000 0,10325338 0,14668485 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,10325338 0,1465943 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,10325338 0,14650387 ! arginine metabolic process GO:0006525 13 12 0,000 0,10325338 0,14641354 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,10325338 0,14632333 ! methionine metabolic process GO:0006555 13 12 0,000 0,10325338 0,14623323 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,10325338 0,14614324 ! Golgi organization GO:0007030 18 12 0,000 0,10325338 0,14605336 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,10325338 0,14596359 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,10325338 0,14587394 ! monoamine transport GO:0015844 13 12 0,000 0,10325338 0,14578439 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,10325338 0,14569495 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,10325338 0,14560562 ! L-amino acid transport GO:0015807 20 12 0,000 0,10325338 0,1455164 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,10325338 0,14542729 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,10325338 0,14533829 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,10325338 0,1452494 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,10325338 0,14516062 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,10325338 0,14507194 ! cerebellum development GO:0021549 13 12 0,000 0,10325338 0,14498337 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,10325338 0,14489492 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,10325338 0,14480657 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,10325338 0,14471832 ! regulation of epidermis development GO:0045682 17 12 0,000 0,10325338 0,14463019 ! intestinal absorption GO:0050892 19 12 0,000 0,10325338 0,14454216 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,10325338 0,14445424 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,10325338 0,14436642 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,10325338 0,14427872 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,10325338 0,14419112 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,10325338 0,14410362 ! microspike assembly GO:0030035 23 12 0,000 0,10325338 0,14401623 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,10325338 0,14392895 ! response to cold GO:0009409 14 12 0,000 0,10325338 0,14384177 ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,1052367 0,14651598 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,1052367 0,14642735 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,1052367 0,14633882 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,1052367 0,1462504 ! cellular hormone metabolic process GO:0034754 87 62 1,000 0,10812563 0,15017448 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,10812563 0,15008385 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,10812563 0,14999333 ! organelle localization GO:0051640 96 62 1,000 0,10812563 0,14990292 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,11136362 0,15429899 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11136362 0,1542061 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11136362 0,15411332 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,11136362 0,15402064 ! water transport GO:0006833 17 13 0,000 0,11136362 0,15392808 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11136362 0,15383563 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11136362 0,1537433 ! lipid localization GO:0010876 24 13 0,000 0,11136362 0,15365107 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11136362 0,15355895 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11136362 0,15346694 ! organelle fusion GO:0048284 28 13 0,000 0,11136362 0,15337505 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11136362 0,15328326 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11136362 0,15319158 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,11136362 0,15310002 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11136362 0,15300856 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11136362 0,15291721 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,11136362 0,15282597 ! glutamate metabolic process GO:0006536 18 13 0,000 0,11136362 0,15273484 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11136362 0,15264382 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,11136362 0,15255291 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! NAD metabolic process GO:0019674 21 13 0,000 0,11136362 0,1524621 ! exocrine system development GO:0035272 27 13 0,000 0,11136362 0,1523714 ! bone mineralization GO:0030282 15 13 0,000 0,11136362 0,15228081 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11136362 0,15219033 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11136362 0,15209996 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11136362 0,15200969 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11136362 0,15191953 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11136362 0,15182948 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,11136362 0,15173953 ! genitalia development GO:0048806 15 13 0,000 0,11136362 0,15164969 ! tissue regeneration GO:0042246 21 13 0,000 0,11136362 0,15155996 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11136362 0,15147033 ! cofactor transport GO:0051181 19 13 0,000 0,11136362 0,15138081 ! NADP metabolic process GO:0006739 18 13 0,000 0,11136362 0,15129139 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11136362 0,15120208 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11136362 0,15111288 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11136362 0,15102378 ! gas transport GO:0015669 18 13 0,000 0,11136362 0,15093478 ! regulation of RNA stability GO:0043487 28 13 0,000 0,11136362 0,15084589 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11136362 0,15075711 ! regulation of axon extension GO:0030516 23 13 0,000 0,11136362 0,15066843 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,11136362 0,15057985 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11136362 0,15049138 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11136362 0,15040301 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11136362 0,15031475 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11136362 0,15022659 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,11396607 0,15364711 ! adaptive immune response GO:0002250 94 64 1,000 0,11396607 0,1535571 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,11691637 0,15744008 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,11691637 0,15734796 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,11691637 0,15725594 ! superoxide anion generation GO:0042554 18 14 0,000 0,11940098 0,16050394 ! neuron maturation GO:0042551 21 14 0,000 0,11940098 0,16041019 ! regulation of S phase GO:0033261 18 14 0,000 0,11940098 0,16031655 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,11940098 0,16022301 ! myotube differentiation GO:0014902 21 14 0,000 0,11940098 0,16012959 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,11940098 0,16003627 ! inositol metabolic process GO:0006020 20 14 0,000 0,11940098 0,15994307 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,11940098 0,15984997 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,11940098 0,15975698 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,11940098 0,1596641 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,11940098 0,15957132 ! gene silencing by RNA GO:0031047 20 14 0,000 0,11940098 0,15947866 ! response to cAMP GO:0051591 19 14 0,000 0,11940098 0,1593861 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,11940098 0,15929365 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,11940098 0,1592013 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,11940098 0,15910906 ! glycine metabolic process GO:0006544 22 14 0,000 0,11940098 0,15901693 ! pituitary gland development GO:0021983 23 14 0,000 0,11940098 0,15892491 ! lysosomal transport GO:0007041 20 14 0,000 0,11940098 0,15883299 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,11940098 0,15874118 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,11940098 0,15864948 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,11940098 0,15855788 ! axon cargo transport GO:0008088 27 14 0,000 0,11940098 0,15846639 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,11940098 0,158375 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,11940098 0,15828371 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,11940098 0,15819254 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,11940098 0,15810147 ! mRNA splice site selection GO:0006376 26 14 0,000 0,11940098 0,1580105 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,11940098 0,15791963 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,11940098 0,15782888 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,11940098 0,15773822 GO:0046466|membrane lipid catabolic process, ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,11940098 0,15764767 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,11940098 0,15755723 ! muscle maintenance GO:0046716 19 14 0,000 0,11940098 0,15746688 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,11940098 0,15737664 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,11940098 0,15728651 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,11940098 0,15719648 ! cell killing GO:0001906 20 14 0,000 0,11940098 0,15710655 ! cilium assembly GO:0042384 20 14 0,000 0,11940098 0,15701672 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,11988594 0,15756437 ! axon guidance GO:0007411 99 66 1,000 0,11988594 0,15747439 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,12287417 0,16130742 ! learning or memory GO:0007611 123 68 1,000 0,12588052 0,16515983 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,12588052 0,16506567 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,12588052 0,16497162 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,12588052 0,16487767 ! rhythmic process GO:0048511 105 68 1,000 0,12588052 0,16478383 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,12736609 0,16663368 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,12736609 0,16653895 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,12736609 0,16644432 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,12736609 0,16634981 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,12736609 0,1662554 ! bile acid metabolic process GO:0008206 22 15 0,000 0,12736609 0,1661611 ! adult walking behavior GO:0007628 25 15 0,000 0,12736609 0,1660669 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,12736609 0,16597281 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,12736609 0,16587883 ! myoblast differentiation GO:0045445 27 15 0,000 0,12736609 0,16578495 ! centrosome cycle GO:0007098 16 15 0,000 0,12736609 0,16569118 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,12736609 0,16559752 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,12736609 0,16550396 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,12736609 0,16541051 ! vesicle coating GO:0006901 25 15 0,000 0,12736609 0,16531716 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,12736609 0,16522392 ! regulation of vasodilation GO:0042312 24 15 0,000 0,12736609 0,16513078 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,12736609 0,16503775 ! neuron recognition GO:0008038 22 15 0,000 0,12736609 0,16494483 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,12736609 0,164852 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,12736609 0,16475929 ! biomineral formation GO:0031214 18 15 0,000 0,12736609 0,16466667 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,12736609 0,16457416 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,12736609 0,16448176 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,12736609 0,16438946 ! dopamine metabolic process GO:0042417 30 15 0,000 0,12736609 0,16429726 ! organic cation transport GO:0015695 19 15 0,000 0,12736609 0,16420516 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,12736609 0,16411317 GO:0033014|tetrapyrrole biosynthetic process, ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,12890439 0,1660023 ! response to metal ion GO:0010038 103 70 1,000 0,13194525 0,16982321 ! eye development GO:0001654 111 70 1,000 0,13194525 0,16972823 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,13500254 0,17356392 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,13500254 0,17346696 ! bone remodeling GO:0046849 24 16 0,000 0,13525961 0,17370023 ! endothelial cell migration GO:0043542 22 16 0,000 0,13525961 0,1736033 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,13525961 0,17350648 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,13525961 0,17340976 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,13525961 0,17331316 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,13525961 0,17321666 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,13525961 0,17312026 ! protein polyubiquitination GO:0000209 26 16 0,000 0,13525961 0,17302398 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,13525961 0,1729278 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,13525961 0,17283173 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,13525961 0,17273577 ! fructose metabolic process GO:0006000 20 16 0,000 0,13525961 0,17263991 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,13525961 0,17254416 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,13525961 0,17244851 ! protein export from nucleus GO:0006611 24 16 0,000 0,13525961 0,17235297 ! negative regulation of immune response GO:0050777 28 16 0,000 0,13525961 0,17225754 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,13525961 0,17216221 ! DNA replication initiation GO:0006270 25 16 0,000 0,13525961 0,17206699 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,13525961 0,17197187 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,13525961 0,17187686 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,13525961 0,17178195 ! diencephalon development GO:0021536 25 16 0,000 0,13525961 0,17168715 ! neural crest cell migration GO:0001755 24 16 0,000 0,13525961 0,17159245 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,13525961 0,17149786 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,13525961 0,17140337 ! steroid catabolic process GO:0006706 22 16 0,000 0,13525961 0,17130898 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,13525961 0,1712147 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,13525961 0,17112052 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,13525961 0,17102645 ! sperm-egg recognition GO:0035036 16 16 0,000 0,13525961 0,17093248 GO:0007339|binding of sperm to zona pellucida, ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,13525961 0,17083861 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,13525961 0,17074485 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,13807573 0,17420415 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,14116427 0,17800319 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,14116427 0,17790565 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,14308218 0,180224 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,14308218 0,18012535 ! negative regulation of defense response GO:0031348 19 17 0,000 0,14308218 0,18002682 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,14308218 0,17992839 ! glycerol metabolic process GO:0006071 20 17 0,000 0,14308218 0,17983007 ! zinc ion transport GO:0006829 20 17 0,000 0,14308218 0,17973185 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,14308218 0,17963375 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,14308218 0,17953575 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,14308218 0,17943785 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,14308218 0,17934007 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,14308218 0,17924239 ! memory GO:0007613 25 17 0,000 0,14308218 0,17914481 ! keratinization GO:0031424 17 17 0,000 0,14308218 0,17904735 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,14308218 0,17894998 ! retinoid metabolic process GO:0001523 22 17 0,000 0,14308218 0,17885273 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,14308218 0,17875558 ! vacuolar transport GO:0007034 24 17 0,000 0,14308218 0,17865853 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,14308218 0,1785616 ! membrane budding GO:0006900 29 17 0,000 0,14308218 0,17846476 ! heme metabolic process GO:0042168 27 17 0,000 0,14308218 0,17836803 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,14308218 0,17827141 ! stem cell differentiation GO:0048863 36 17 0,000 0,14308218 0,17817489 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,14308218 0,17807847 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,14308218 0,17798216 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,14308218 0,17788596 ! sensory perception of pain GO:0019233 23 17 0,000 0,14308218 0,17778985 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,14308218 0,17769386 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,14308218 0,17759796 ! synaptogenesis GO:0007416 24 17 0,000 0,14308218 0,17750217 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,14308218 0,17740648 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,14308218 0,1773109 ! cell-cell junction organization GO:0045216 25 17 0,000 0,14308218 0,17721541 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,14308218 0,17712003 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,14308218 0,17702476 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,14308218 0,17692958 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,14308218 0,17683451 ! phospholipid biosynthetic process GO:0008654 102 74 1,000 0,14426764 0,17820386 ! protein import into nucleus GO:0006606 118 74 1,000 0,14426764 0,1781082 ! response to inorganic substance GO:0010035 115 75 1,000 0,14738534 0,1818596 ! nuclear import GO:0051170 121 75 1,000 0,14738534 0,18176208 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,15083443 0,18591597 ! positive regulation of translation GO:0045727 28 18 0,000 0,15083443 0,18581639 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,15083443 0,18571691 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,15083443 0,18561755 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,15083443 0,18551828 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,15083443 0,18541913 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,15083443 0,18532008 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,15083443 0,18522114 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,15083443 0,1851223 ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,15083443 0,18502357 ! pancreas development GO:0031016 26 18 0,000 0,15083443 0,18492494 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,15083443 0,18482642 ! glutamine metabolic process GO:0006541 23 18 0,000 0,15083443 0,184728 ! central nervous system neuron development GO:0021954 30 18 0,000 0,15083443 0,18462969 ! fucose metabolic process GO:0006004 26 18 0,000 0,15083443 0,18453149 ! response to fungus GO:0009620 19 18 0,000 0,15083443 0,18443338 ! peptide cross-linking GO:0018149 31 18 0,000 0,15083443 0,18433538 ! heart process GO:0003015 27 18 0,000 0,15083443 0,18423749 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,15083443 0,1841397 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,15083443 0,18404201 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,15083443 0,18394443 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,15083443 0,18384695 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,15083443 0,18374957 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,15083443 0,1836523 ! vitamin transport GO:0051180 24 18 0,000 0,15083443 0,18355513 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,15083443 0,18345806 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,15083443 0,1833611 ! cell-cell recognition GO:0009988 20 18 0,000 0,15083443 0,18326423 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,15083443 0,18316747 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,15083443 0,18307081 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,15366168 0,18640393 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,15366168 0,18630567 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,15366168 0,18620751 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,15681932 0,18993388 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,15851699 0,19188898 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,15851699 0,19178804 ! positive regulation of ossification GO:0045778 30 19 0,000 0,15851699 0,19168721 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,15851699 0,19158648 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,15851699 0,19148586 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,15851699 0,19138534 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,15851699 0,19128493 ! sensory perception of taste GO:0050909 23 19 0,000 0,15851699 0,19118462 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,15851699 0,19108442 ! peroxisome organization GO:0007031 29 19 0,000 0,15851699 0,19098432 ! digestive system process GO:0022600 30 19 0,000 0,15851699 0,19088433 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,15851699 0,19078444 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,15851699 0,19068466 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,15851699 0,19058498 ! plasma membrane fusion GO:0045026 23 19 0,000 0,15851699 0,19048541 ! cytolysis GO:0019835 20 19 0,000 0,15851699 0,19038594 ! vasodilation GO:0042311 33 19 0,000 0,15851699 0,19028657 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,15851699 0,19018731 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,15851699 0,19008815 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,15851699 0,18998909 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,15851699 0,18989014 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,15851699 0,18979129 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,15851699 0,18969254 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,15851699 0,1895939 ! sarcomere organization GO:0045214 23 19 0,000 0,15851699 0,18949536 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,15851699 0,18939692 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,15851699 0,18929858 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,15851699 0,18920035 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,15851699 0,18910222 GO:0043450|alkene biosynthetic process, ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,15851699 0,18900418 ! protein stabilization GO:0050821 26 19 0,000 0,15851699 0,18890625 ! regulation of lyase activity GO:0051339 133 79 1,000 0,1599893 0,19056209 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,16317115 0,19425137 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,16317115 0,19415087 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,16317115 0,19405049 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,16613047 0,19746775 ! iron ion transport GO:0006826 37 20 0,000 0,16613047 0,19736575 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,16613047 0,19726386 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,16613047 0,19716207 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,16613047 0,19706039 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,16613047 0,19695881 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,16613047 0,19685734 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,16613047 0,19675597 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,16613047 0,1966547 ! chromosome condensation GO:0030261 31 20 0,000 0,16613047 0,19655354 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,16613047 0,19645249 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,16613047 0,19635154 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,16613047 0,19625069 ! DNA modification GO:0006304 28 20 0,000 0,16613047 0,19614994 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,16613047 0,1960493 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,16613047 0,19594876 ! collagen catabolic process GO:0030574 25 20 0,000 0,16613047 0,19584833 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,16613047 0,195748 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,16613047 0,19564777 ! alditol metabolic process GO:0019400 24 20 0,000 0,16613047 0,19554764 ! actin filament-based movement GO:0030048 34 20 0,000 0,16613047 0,19544762 ! response to protein stimulus GO:0051789 111 81 1,000 0,16636438 0,19562274 ! vitamin metabolic process GO:0006766 103 81 1,000 0,16636438 0,19552278 ! detection of stimulus GO:0051606 108 82 1,000 0,16956855 0,19918675 ! regulation of cell killing GO:0031341 34 21 0,000 0,17367551 0,20390693 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,17367551 0,20380289 ! gluconeogenesis GO:0006094 25 21 0,000 0,17367551 0,20369896 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,17367551 0,20359514 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,17367551 0,20349143 ! vesicle docking GO:0048278 27 21 0,000 0,17367551 0,20338781 ! phototransduction GO:0007602 25 21 0,000 0,17367551 0,20328431 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,17367551 0,20318091 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,17367551 0,20307761 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,17367551 0,20297443 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,17367551 0,20287134 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,17367551 0,20276836 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,17367551 0,20266548 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,17367551 0,20256271 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,17367551 0,20246004 ! fatty acid transport GO:0015908 30 21 0,000 0,17367551 0,20235748 ! platelet activation GO:0030168 28 21 0,000 0,17367551 0,20225502 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,17367551 0,20215267 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,17367551 0,20205041 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,17367551 0,20194827 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,17367551 0,20184622 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,17367551 0,20174428 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,17367551 0,20164244 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,17367551 0,2015407 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,17367551 0,20143907 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,17367551 0,20133753 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,17367551 0,20123611 ! rRNA metabolic process GO:0016072 107 85 1,000 0,17924212 0,20758151 GO:0006364|rRNA processing, ! viral genome replication GO:0019079 29 22 0,000 0,1811527 0,20968858 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,1811527 0,20958311 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,1811527 0,20947773 ! leukocyte adhesion GO:0007159 38 22 0,000 0,1811527 0,20937247 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,1811527 0,20926731 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,1811527 0,20916226 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,1811527 0,20905731 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,1811527 0,20895246 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,1811527 0,20884773 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,1811527 0,20874309 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,1811527 0,20863856 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,1811527 0,20853414 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,1811527 0,20842982 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,1811527 0,20832561 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,1811527 0,2082215 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,1811527 0,20811749 ! blastocyst development GO:0001824 37 22 0,000 0,1811527 0,20801359 ! neuron fate commitment GO:0048663 32 23 0,000 0,18856266 0,21641423 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,18856266 0,21630629 ! vesicle targeting GO:0006903 32 23 0,000 0,18856266 0,21619846 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,18856266 0,21609074 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,18856266 0,21598313 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,18856266 0,21587562 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,18856266 0,21576822 ! cell fate determination GO:0001709 45 23 0,000 0,18856266 0,21566092 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,18856266 0,21555374 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,18856266 0,21544666 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,18856266 0,21533968 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,18856266 0,21523281 ! telomere organization GO:0032200 32 23 0,000 0,18856266 0,21512605 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,18856266 0,21501939 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,18856266 0,21491284 ! regulation of amine transport GO:0051952 38 23 0,000 0,18856266 0,2148064 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,18899814 0,2151959 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,19226649 0,21880897 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,19590598 0,22284063 ! initiation of viral infection GO:0019059 42 24 0,000 0,19590598 0,22273048 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,19590598 0,22262044 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,19590598 0,2225105 ! superoxide metabolic process GO:0006801 32 24 0,000 0,19590598 0,22240067 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,19590598 0,22229095 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,19590598 0,22218134 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,19590598 0,22207184 ! sperm motility GO:0030317 27 24 0,000 0,19590598 0,22196244 ! vacuole organization GO:0007033 39 24 0,000 0,19590598 0,22185316 ! receptor metabolic process GO:0043112 37 24 0,000 0,19590598 0,22174398 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,19590598 0,22163491 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,19590598 0,22152594 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,19590598 0,22141708 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,19590598 0,22130833 ! response to virus GO:0009615 122 91 1,000 0,19882528 0,2244959 ! sulfur metabolic process GO:0006790 118 92 1,000 0,20211493 0,2280983 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,20318327 0,22919153 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,20318327 0,22907918 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,20318327 0,22896694 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,20318327 0,22885481 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,20318327 0,22874279 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,20318327 0,22863088 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,20318327 0,22851908 ! phospholipid transport GO:0015914 35 25 0,000 0,20318327 0,22840739 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,20318327 0,22829581 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,20318327 0,22818434 ! detection of light stimulus GO:0009583 30 25 0,000 0,20318327 0,22807297 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,21039511 0,23605305 ! translational initiation GO:0006413 43 26 0,000 0,21039511 0,23593796 ! circadian rhythm GO:0007623 42 26 0,000 0,21039511 0,23582298 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,21039511 0,23570811 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,21039511 0,23559335 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,21039511 0,23547871 GO:0046496|nicotinamide nucleotide metabolic process, ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,21039511 0,23536418 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,21533289 0,24077085 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,21754208 0,24312283 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,21754208 0,24300475 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,21754208 0,24288679 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,21754208 0,24276894 ! membrane docking GO:0022406 39 27 0,000 0,21754208 0,24265121 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,21754208 0,24253358 ! catechol metabolic process GO:0009712 43 27 0,000 0,21754208 0,24241608 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! acute-phase response GO:0006953 42 27 0,000 0,21754208 0,24229869 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,21754208 0,24218141 ! myofibril assembly GO:0030239 36 27 0,000 0,21754208 0,24206424 GO:0055002|striated muscle cell development, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,21754208 0,24194719 ! natural killer cell activation GO:0030101 35 27 0,000 0,21754208 0,24183025 ! lipid oxidation GO:0034440 38 27 0,000 0,21754208 0,24171342 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,21754208 0,24159671 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,21754208 0,24148011 ! gene silencing GO:0016458 41 27 0,000 0,21754208 0,24136362 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,21865037 0,24247631 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! mRNA export from nucleus GO:0006406 39 28 0,000 0,22462477 0,24898167 ! phenol metabolic process GO:0018958 44 28 0,000 0,22462477 0,24886174 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,22462477 0,24874192 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,22462477 0,24862222 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,22462477 0,24850263 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,22462477 0,24838316 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,22462477 0,2482638 GO:0055092|sterol homeostasis, ! complement activation, classical pathway GO:0006958 36 28 0,000 0,22462477 0,24814456 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,22462477 0,24802543 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,22462477 0,24790642 GO:0002764|immune response-regulating signal transduction, ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,22462477 0,24778752 ! mesoderm formation GO:0001707 46 28 0,000 0,22462477 0,24766873 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,22462477 0,24755006 ! BMP signaling pathway GO:0030509 40 28 0,000 0,22462477 0,2474315 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,22462477 0,24731306 ! placenta development GO:0001890 37 28 0,000 0,22462477 0,24719472 ! protein import GO:0017038 156 99 1,000 0,22529843 0,2478175 ! regulation of translation GO:0006417 151 100 1,000 0,22862831 0,25135999 ! protein localization in organelle GO:0033365 161 100 1,000 0,22862831 0,2512399 ! regulation of innate immune response GO:0045088 38 29 0,000 0,23164375 0,25443201 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,23164375 0,25431056 ! protein targeting to membrane GO:0006612 53 29 0,000 0,23164375 0,25418923 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,23164375 0,25406802 ! muscle cell development GO:0055001 38 29 0,000 0,23164375 0,25394691 ! formation of primary germ layer GO:0001704 48 29 0,000 0,23164375 0,25382593 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,23164375 0,25370506 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,23164375 0,25358431 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,23859959 0,26107472 ! collagen metabolic process GO:0032963 40 30 0,000 0,23859959 0,26095058 ! organic anion transport GO:0015711 51 30 0,000 0,23859959 0,26082655 ! cholesterol transport GO:0030301 46 30 0,000 0,23859959 0,26070264 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,23859959 0,26057885 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,23859959 0,26045518 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,23859959 0,26033162 ! ceramide metabolic process GO:0006672 43 30 0,000 0,23859959 0,26020818 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,23859959 0,26008486 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,23859959 0,25996166 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,23859959 0,25983857 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,24549286 0,26721892 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,24549286 0,26709251 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,24549286 0,26696623 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,24549286 0,26684006 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,24549286 0,26671402 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,24549286 0,26658809 ! RNA modification GO:0009451 40 31 0,000 0,24549286 0,26646228 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,25232411 0,27374785 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,25232411 0,27361879 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,25232411 0,27348984 ! vesicle localization GO:0051648 47 32 0,000 0,25232411 0,27336102 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,25909389 0,28056307 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,25909389 0,28043104 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,25909389 0,28029913 ! actomyosin structure organization GO:0031032 43 33 0,000 0,25909389 0,28016735 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,25909389 0,28003569 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,25909389 0,27990416 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,25909389 0,27977275 ! lipid homeostasis GO:0055088 55 33 0,000 0,25909389 0,27964146 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,25909389 0,2795103 ! mRNA catabolic process GO:0006402 48 34 0,000 0,26580277 0,28661339 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,26580277 0,28647909 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,26580277 0,2863449 ! feeding behavior GO:0007631 45 34 0,000 0,26580277 0,28621085 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,26580277 0,28607692 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,26580277 0,28594311 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,26580277 0,28580943 ! polyol metabolic process GO:0019751 44 34 0,000 0,26580277 0,28567587 ! aerobic respiration GO:0009060 47 34 0,000 0,26580277 0,28554244 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,26580277 0,28540914 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,27245128 0,29241154 ! Notch signaling pathway GO:0007219 56 35 0,000 0,27245128 0,29227516 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,27245128 0,2921389 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,27245128 0,29200277 GO:0032313|regulation of Rab GTPase activity, ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,27245128 0,29186676 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,27245128 0,29173088 ! glycogen metabolic process GO:0005977 48 35 0,000 0,27245128 0,29159513 ! protein homooligomerization GO:0051260 52 35 0,000 0,27245128 0,29145951 ! tissue remodeling GO:0048771 62 36 0,000 0,27903996 0,29836908 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,27903996 0,29823044 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,27903996 0,29809192 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,27903996 0,29795353 ! glucan metabolic process GO:0044042 49 36 0,000 0,27903996 0,29781527 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,28556934 0,30464262 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,28556934 0,30450139 ! ion transmembrane transport GO:0034220 56 37 0,000 0,28556934 0,30436028 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,28556934 0,30421931 ! amino acid activation GO:0043038 52 37 0,000 0,28556934 0,30407847 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,28556934 0,30393776 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,29203997 0,31068082 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,29203997 0,31053718 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,29203997 0,31039368 ! phagocytosis GO:0006909 60 38 0,000 0,29203997 0,31025031 ! maintenance of location in cell GO:0051651 69 38 0,000 0,29203997 0,31010708 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,29845236 0,31676992 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,29845236 0,31662381 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,30480703 0,3232163 ! response to calcium ion GO:0051592 58 40 0,000 0,30480703 0,32306736 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,30480703 0,32291854 ! inner ear development GO:0048839 57 40 0,000 0,30480703 0,32276987 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,30480703 0,32262133 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,30480703 0,32247294 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,30480703 0,32232467 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,3111045 0,32883288 ! endosome transport GO:0016197 71 41 0,000 0,3111045 0,32868183 ! striated muscle contraction GO:0006941 62 41 0,000 0,3111045 0,32853092 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,3111045 0,32838015 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,31734528 0,33481383 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,31734528 0,33466031 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,31734528 0,33450694 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,31734528 0,33435371 ! regulation of cell shape GO:0008360 78 42 0,000 0,31734528 0,33420062 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,32352988 0,34055777 ! tRNA processing GO:0008033 49 43 0,000 0,32352988 0,34040198 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,32352988 0,34024633 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,3296588 0,34653348 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,3296588 0,34637517 ! glycolysis GO:0006096 53 44 0,000 0,3296588 0,34621701 ! regulation of ion transport GO:0043269 57 44 0,000 0,3296588 0,34605899 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,3296588 0,34590112 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,3296588 0,34574339 ! RNA catabolic process GO:0006401 64 45 0,000 0,33573255 0,35195299 ! regulation of translational initiation GO:0006446 64 45 0,000 0,33573255 0,35179264 ! cell recognition GO:0008037 58 45 0,000 0,33573255 0,35163245 ! cell redox homeostasis GO:0045454 63 46 0,000 0,3417516 0,35777364 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,3417516 0,35761086 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,3417516 0,35744824 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,34771646 0,36352175 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,34771646 0,36335659 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,34771646 0,36319158 ! chloride transport GO:0006821 67 48 0,000 0,3536276 0,36919813 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,3536276 0,36903062 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,3536276 0,36886326 ! gastrulation GO:0007369 73 48 0,000 0,3536276 0,36869605 ! regulation of endocytosis GO:0030100 63 48 0,000 0,3536276 0,36852899 ! nuclear export GO:0051168 69 48 0,000 0,3536276 0,36836208 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,3536276 0,36819533 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,35948551 0,3741252 ! sensory perception of smell GO:0007608 61 49 0,000 0,35948551 0,37395598 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,35948551 0,37378693 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,35948551 0,37361802 ! maintenance of location GO:0051235 84 49 0,000 0,35948551 0,37344927 ! regulation of actin filament length GO:0030832 72 50 0,000 0,36529067 0,3793086 ! membrane fusion GO:0006944 80 50 0,000 0,36529067 0,37913743 ! proton transport GO:0015992 75 50 0,000 0,36529067 0,37896641 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,36529067 0,37879555 ! hydrogen transport GO:0006818 77 51 0,000 0,37104354 0,38458772 ! transition metal ion transport GO:0000041 74 52 0,000 0,3767446 0,39032098 ! regulation of cellular component size GO:0032535 74 52 0,000 0,3767446 0,39014524 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,3767446 0,38996966 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,3823943 0,39563963 ! single fertilization GO:0007338 59 53 0,000 0,3823943 0,39546174 ! cell projection assembly GO:0030031 76 53 0,000 0,3823943 0,395284 ! amino acid transport GO:0006865 84 54 0,000 0,38799312 0,40089136 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,38799312 0,40071135 ! glucose catabolic process GO:0006007 66 54 0,000 0,38799312 0,40053149 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,38799312 0,4003518 ! exocytosis GO:0006887 74 55 0,000 0,39354149 0,40589481 ! mesoderm development GO:0007498 76 55 0,000 0,39354149 0,40571288 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,39354149 0,40553111 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,40448873 0,41662521 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,40448873 0,41643871 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,40988849 0,42180919 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,42054248 0,43257947 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,42054248 0,4323861 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,42054248 0,4321929 ! fertilization GO:0009566 68 60 0,000 0,42054248 0,43199987 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,42579757 0,43720287 ! amine catabolic process GO:0009310 90 62 0,000 0,43100531 0,44235262 ! neurotransmitter transport GO:0006836 81 62 0,000 0,43100531 0,44215532 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,43616611 0,44725014 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,4412804 0,45229274 ! hexose catabolic process GO:0019320 82 64 0,000 0,4412804 0,45209128 ! defense response to bacterium GO:0042742 73 65 0,000 0,44634859 0,45708003 ! activation of immune response GO:0002253 83 65 0,000 0,44634859 0,45687661 ! antigen processing and presentation GO:0019882 96 66 0,000 0,45137109 0,46181206 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,45137109 0,46160672 ! regulation of immune effector process GO:0002697 101 66 0,000 0,45137109 0,46140156 ! acute inflammatory response GO:0002526 92 68 0,000 0,46128067 0,47132188 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,46128067 0,47111259 ! inorganic anion transport GO:0015698 93 68 0,000 0,46128067 0,47090348 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,46616856 0,4756822 ! amine transport GO:0015837 101 70 0,000 0,47101237 0,48041173 ! muscle cell differentiation GO:0042692 104 71 0,000 0,47581251 0,48509255 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,47581251 0,48487762 ! digestion GO:0007586 97 74 0,000 0,48995478 0,4990682 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,49458409 0,50356061 ! amine biosynthetic process GO:0009309 97 76 0,000 0,49917166 0,50800655 ! tRNA metabolic process GO:0006399 95 76 0,000 0,49917166 0,50778187 ! response to unfolded protein GO:0006986 99 76 0,000 0,49917166 0,50755739 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,49917166 0,5073331 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,50371784 0,51172749 ! protein ubiquitination GO:0016567 125 77 0,000 0,50371784 0,51150156 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,50371784 0,51127583 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,50822302 0,51562106 ! cellular respiration GO:0045333 107 79 0,000 0,51268755 0,51992124 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,51268755 0,5196921 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,51268755 0,51946316 ! chromatin assembly GO:0031497 102 80 0,000 0,51711181 0,52371518 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,51711181 0,52348467 ! mRNA transport GO:0051028 121 81 0,000 0,52149615 0,52769078 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,53014652 0,536208 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,53441325 0,54028592 ! sterol metabolic process GO:0016125 120 84 0,000 0,53441325 0,54004854 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,53864148 0,5440823 ! nucleosome organization GO:0034728 114 87 0,000 0,5469838 0,55226635 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,5469838 0,55202402 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,5469838 0,55178191 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,55109858 0,55568906 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,55109858 0,55544555 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,55109858 0,55520225 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,55921705 0,56313451 ! RNA localization GO:0006403 135 91 0,000 0,5632214 0,5669187 ! ATP metabolic process GO:0046034 137 91 0,000 0,5632214 0,5666707 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,5671896 0,57041368 ! positive regulation of immune response GO:0050778 121 92 0,000 0,5671896 0,57016437 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,57112198 0,57386656 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,57112198 0,57361596 ! electron transport chain GO:0022900 123 94 0,000 0,57501885 0,57727777 ! carboxylic acid transport GO:0046942 147 95 0,000 0,57888054 0,58090107 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,58270736 0,58448623 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,58270736 0,58423144 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,58649962 0,5877774 ! calcium ion transport GO:0006816 167 99 0,000 0,59398171 0,59501652 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,59767215 0,59845274 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,59767215 0,59819231 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,59767215 0,59793212 ! divalent metal ion transport GO:0070838 171 100 0,000 0,59767215 0,59767215