pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6434-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 9,000 1,128E-11 2,713E-08 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 4,000 1,093E-09 1,315E-06 ! negative regulation of protein kinase activity GO:0006469 130 67 8,000 1,489E-09 1,194E-06 ! negative regulation of kinase activity GO:0033673 131 68 8,000 1,705E-09 1,026E-06 ! negative regulation of transferase activity GO:0051348 140 72 8,000 2,871E-09 1,382E-06 ! apoptotic mitochondrial changes GO:0008637 41 20 5,000 5,05E-09 2,025E-06 ! nerve growth factor processing GO:0032455 8 5 3,000 1,378E-08 4,735E-06 ! positive regulation of MAP kinase activity GO:0043406 160 93 8,000 2,842E-08 8,548E-06 ! interphase of mitotic cell cycle GO:0051329 209 95 8,000 3,428E-08 9,165E-06 ! induction of apoptosis by intracellular signals GO:0008629 93 45 6,000 3,616E-08 8,7E-06 ! release of cytochrome c from mitochondria GO:0001836 30 14 4,000 3,771E-08 8,249E-06 ! interphase GO:0051325 213 98 8,000 4,506E-08 9,034E-06 ! response to UV GO:0009411 104 53 6,000 1,169E-07 2,163E-05 ! cell cycle checkpoint GO:0000075 137 69 6,000 7,411E-07 1,274E-04 ! negative regulation of phosphorylation GO:0042326 47 24 4,000 7,543E-07 1,21E-04 ! branching morphogenesis of a tube GO:0048754 97 45 5,000 9,112E-07 1,37E-04 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 4,000 9,373E-07 1,327E-04 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 5,000 1,042E-06 1,392E-04 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 4,000 1,154E-06 1,461E-04 GO:0045936|negative regulation of phosphate metabolic process, ! morphogenesis of a branching structure GO:0001763 111 52 5,000 2,183E-06 2,626E-04 ! regulation of neuron apoptosis GO:0043523 100 53 5,000 2,446E-06 2,803E-04 ! tube morphogenesis GO:0035239 176 86 6,000 3,323E-06 3,634E-04 ! negative regulation of MAP kinase activity GO:0043407 69 32 4,000 3,408E-06 3,565E-04 ! peptide hormone processing GO:0016486 23 15 3,000 3,551E-06 3,559E-04 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 2,000 3,804E-06 3,661E-04 ! peptidyl-threonine phosphorylation GO:0018107 20 5 2,000 3,804E-06 3,52E-04 ! DNA damage checkpoint GO:0000077 71 33 4,000 3,993E-06 3,558E-04 ! DNA damage response, signal transduction GO:0042770 128 60 5,000 5,112E-06 4,393E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 3,000 6,12E-06 5,077E-04 ! neutrophil chemotaxis GO:0030593 27 17 3,000 6,12E-06 4,908E-04 ! negative regulation of blood coagulation GO:0030195 24 17 3,000 6,12E-06 4,75E-04 ! DNA integrity checkpoint GO:0031570 75 36 4,000 6,23E-06 4,684E-04 ! meiosis I GO:0007127 65 37 4,000 7,161E-06 5,221E-04 ! negative regulation of gliogenesis GO:0014014 18 6 2,000 7,567E-06 5,355E-04 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 14 6 2,000 7,567E-06 5,202E-04 ! negative regulation of neuroblast proliferation GO:0007406 21 6 2,000 7,567E-06 5,057E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 5,000 9,767E-06 6,351E-04 ! mesenchymal cell development GO:0014031 87 40 4,000 1,062E-05 6,723E-04 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! urogenital system development GO:0001655 137 69 5,000 1,159E-05 7,151E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 3,000 1,225E-05 7,366E-04 ! negative regulation of coagulation GO:0050819 29 20 3,000 1,225E-05 7,186E-04 ! prostate gland development GO:0030850 13 7 2,000 1,317E-05 7,545E-04 ! fibrinolysis GO:0042730 10 7 2,000 1,317E-05 7,369E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 2,000 1,317E-05 7,202E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 1,317E-05 7,042E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 1,317E-05 6,889E-04 ! peptidyl-threonine modification GO:0018210 25 7 2,000 1,317E-05 6,742E-04 ! meiosis GO:0007126 121 74 5,000 1,738E-05 8,71E-04 GO:0051327|M phase of meiotic cell cycle, ! renal system process GO:0003014 41 22 3,000 1,828E-05 8,975E-04 ! meiotic cell cycle GO:0051321 122 75 5,000 1,877E-05 9,033E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 2,096E-05 9,887E-04 ! pigmentation GO:0043473 100 46 4,000 2,135E-05 9,877E-04 ! regulation of cell-matrix adhesion GO:0001952 78 23 3,000 2,2E-05 9,987E-04 GO:0010810|regulation of cell-substrate adhesion, ! activation of protein kinase activity GO:0032147 147 79 5,000 2,529E-05 1,127E-03 ! positive regulation of phosphorylation GO:0042327 129 79 5,000 2,529E-05 1,106E-03 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 3,000 2,625E-05 1,128E-03 ! positive regulation of cell cycle GO:0045787 89 48 4,000 2,635E-05 1,112E-03 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 5,000 2,918E-05 1,21E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 171 81 5,000 2,918E-05 1,19E-03 ! negative regulation of cell development GO:0010721 73 25 3,000 3,107E-05 1,246E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of blood coagulation GO:0030193 40 25 3,000 3,107E-05 1,225E-03 ! induction of positive chemotaxis GO:0050930 15 9 2,000 3,127E-05 1,213E-03 ! middle ear morphogenesis GO:0042474 14 9 2,000 3,127E-05 1,194E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 2,000 3,127E-05 1,175E-03 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 2,000 3,127E-05 1,157E-03 GO:0007351|tripartite regional subdivision, ! response to oxygen levels GO:0070482 176 83 5,000 3,352E-05 1,222E-03 ! negative regulation of transport GO:0051051 153 84 5,000 3,588E-05 1,289E-03 ! insulin receptor signaling pathway GO:0008286 64 26 3,000 3,651E-05 1,292E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 3,000 3,651E-05 1,273E-03 ! positive regulation of nuclear division GO:0051785 40 26 3,000 3,651E-05 1,255E-03 GO:0045840|positive regulation of mitosis, ! regulation of angiogenesis GO:0045765 114 52 4,000 3,906E-05 1,324E-03 ! positive regulation of growth GO:0045927 90 52 4,000 3,906E-05 1,305E-03 ! mitochondrion organization GO:0007005 148 86 5,000 4,1E-05 1,351E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 3,000 4,261E-05 1,386E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 4,443E-05 1,425E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 4,443E-05 1,406E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 2,000 4,443E-05 1,388E-03 ! regulation of gliogenesis GO:0014013 23 10 2,000 4,443E-05 1,37E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of insulin receptor signaling pathway GO:0046626 19 10 2,000 4,443E-05 1,353E-03 ! blastoderm segmentation GO:0007350 18 10 2,000 4,443E-05 1,336E-03 ! gland development GO:0048732 206 88 5,000 4,67E-05 1,387E-03 ! peptidyl-tyrosine modification GO:0018212 50 28 3,000 4,943E-05 1,45E-03 ! regulation of JUN kinase activity GO:0043506 58 28 3,000 4,943E-05 1,433E-03 ! regulation of cell cycle process GO:0010564 149 90 5,000 5,3E-05 1,518E-03 ! negative regulation of neuron apoptosis GO:0043524 56 29 3,000 5,701E-05 1,614E-03 ! regulation of coagulation GO:0050818 46 29 3,000 5,701E-05 1,595E-03 ! UV protection GO:0009650 19 11 2,000 6,076E-05 1,68E-03 ! chondrocyte differentiation GO:0002062 24 11 2,000 6,076E-05 1,661E-03 ! embryonic axis specification GO:0000578 18 11 2,000 6,076E-05 1,643E-03 ! anterior/posterior axis specification GO:0009948 18 11 2,000 6,076E-05 1,624E-03 ! negative regulation of glucose import GO:0046325 17 11 2,000 6,076E-05 1,606E-03 GO:0010829|negative regulation of glucose transport, ! positive regulation of cell migration GO:0030335 126 57 4,000 6,109E-05 1,598E-03 ! negative regulation of multicellular organismal process GO:0051241 166 93 5,000 6,372E-05 1,648E-03 ! transcription initiation GO:0006352 153 94 5,000 6,765E-05 1,732E-03 ! regulation of B cell proliferation GO:0030888 20 12 2,000 8,058E-05 2,041E-03 ! regulation of positive chemotaxis GO:0050926 19 12 2,000 8,058E-05 2,019E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 35 12 2,000 8,058E-05 1,999E-03 ! autonomic nervous system development GO:0048483 24 12 2,000 8,058E-05 1,978E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 8,058E-05 1,958E-03 GO:0042130|negative regulation of T cell proliferation, ! hormone metabolic process GO:0042445 157 97 5,000 8,063E-05 1,94E-03 ! response to peptide hormone stimulus GO:0043434 122 61 4,000 8,477E-05 2,019E-03 ! leukocyte chemotaxis GO:0030595 50 33 3,000 9,601E-05 2,265E-03 GO:0060326|cell chemotaxis, ! regulation of mitosis GO:0007088 105 63 4,000 9,897E-05 2,312E-03 GO:0051783|regulation of nuclear division, ! positive regulation of cell motion GO:0051272 146 64 4,000 1,067E-04 2,469E-03 ! regulation of striated muscle tissue development GO:0016202 69 34 3,000 1,082E-04 2,479E-03 ! regulation of muscle development GO:0048634 70 35 3,000 1,214E-04 2,757E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 2,000 1,319E-04 2,966E-03 ! response to gamma radiation GO:0010332 28 14 2,000 1,319E-04 2,938E-03 ! negative regulation of cell growth GO:0030308 132 67 4,000 1,328E-04 2,932E-03 ! activation of MAPK activity GO:0000187 115 67 4,000 1,328E-04 2,905E-03 ! androgen receptor signaling pathway GO:0030521 74 36 3,000 1,359E-04 2,945E-03 ! cellular response to insulin stimulus GO:0032869 82 37 3,000 1,515E-04 3,253E-03 ! negative regulation of cell size GO:0045792 134 69 4,000 1,527E-04 3,252E-03 ! respiratory tube development GO:0030323 150 70 4,000 1,635E-04 3,451E-03 ! positive regulation of cell size GO:0045793 27 15 2,000 1,64E-04 3,43E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 1,64E-04 3,401E-03 ! epithelial to mesenchymal transition GO:0001837 28 15 2,000 1,64E-04 3,372E-03 ! regulation of MAPKKK cascade GO:0043408 142 71 4,000 1,749E-04 3,565E-03 ! segmentation GO:0035282 67 39 3,000 1,865E-04 3,77E-03 ! regulation of caspase activity GO:0043281 122 72 4,000 1,868E-04 3,745E-03 ! activation of MAPKK activity GO:0000186 35 16 2,000 2,007E-04 3,991E-03 ! negative regulation of microtubule depolymerization GO:0007026 46 16 2,000 2,007E-04 3,958E-03 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 2,007E-04 3,926E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 2,000 2,007E-04 3,895E-03 ! regulation of endopeptidase activity GO:0052548 125 74 4,000 2,125E-04 4,091E-03 ! cell-matrix adhesion GO:0007160 163 75 4,000 2,264E-04 4,323E-03 ! phosphoinositide-mediated signaling GO:0048015 131 75 4,000 2,264E-04 4,289E-03 ! regulation of T cell differentiation GO:0045580 70 41 3,000 2,27E-04 4,267E-03 ! DNA integration GO:0015074 29 17 2,000 2,424E-04 4,521E-03 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 2,000 2,424E-04 4,487E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 2,000 2,424E-04 4,452E-03 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 4,000 2,72E-04 4,959E-03 ! regulation of peptidase activity GO:0052547 134 79 4,000 2,887E-04 5,223E-03 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 2,000 2,893E-04 5,195E-03 GO:0050886|endocrine process, ! patterning of blood vessels GO:0001569 39 18 2,000 2,893E-04 5,157E-03 ! epidermis morphogenesis GO:0048730 40 18 2,000 2,893E-04 5,119E-03 ! cell-substrate junction assembly GO:0007044 54 18 2,000 2,893E-04 5,081E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 2,893E-04 5,045E-03 ! regulation of BMP signaling pathway GO:0030510 32 18 2,000 2,893E-04 5,008E-03 ! cell-substrate adhesion GO:0031589 171 81 4,000 3,244E-04 5,575E-03 ! leukocyte migration GO:0050900 68 45 3,000 3,264E-04 5,57E-03 ! skin development GO:0043588 36 19 2,000 3,417E-04 5,79E-03 ! actin filament bundle formation GO:0051017 42 19 2,000 3,417E-04 5,75E-03 ! regulation of endothelial cell migration GO:0010594 44 19 2,000 3,417E-04 5,71E-03 ! cellular response to hormone stimulus GO:0032870 167 82 4,000 3,434E-04 5,698E-03 ! negative regulation of cell migration GO:0030336 115 46 3,000 3,555E-04 5,858E-03 ! response to insulin stimulus GO:0032868 95 46 3,000 3,555E-04 5,818E-03 ! negative regulation of growth GO:0045926 155 84 4,000 3,84E-04 6,243E-03 ! regulation of JNK cascade GO:0046328 94 47 3,000 3,863E-04 6,238E-03 ! response to alkaloid GO:0043279 38 20 2,000 3,999E-04 6,414E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 3,999E-04 6,372E-03 ! regulation of glucose import GO:0046324 29 20 2,000 3,999E-04 6,33E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 40 20 2,000 3,999E-04 6,288E-03 ! cellular component disassembly GO:0022411 86 48 3,000 4,191E-04 6,547E-03 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 3,000 4,191E-04 6,505E-03 ! activation of caspase activity GO:0006919 84 48 3,000 4,191E-04 6,463E-03 ! regulation of lymphocyte differentiation GO:0045619 81 48 3,000 4,191E-04 6,422E-03 ! regulation of mast cell proliferation GO:0070666 81 48 3,000 4,191E-04 6,381E-03 ! reciprocal meiotic recombination GO:0007131 39 21 2,000 4,64E-04 7,022E-03 ! axis specification GO:0009798 38 21 2,000 4,64E-04 6,978E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 4,64E-04 6,934E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 4,64E-04 6,892E-03 ! cell aging GO:0007569 44 21 2,000 4,64E-04 6,849E-03 ! regulation of vasoconstriction GO:0019229 39 21 2,000 4,64E-04 6,808E-03 ! positive regulation of locomotion GO:0040017 39 21 2,000 4,64E-04 6,766E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 59 21 2,000 4,64E-04 6,726E-03 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 4,64E-04 6,685E-03 ! gut development GO:0048565 39 21 2,000 4,64E-04 6,646E-03 ! regulation of cell adhesion GO:0030155 212 89 4,000 5,013E-04 7,137E-03 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 1,000 5,236E-04 7,41E-03 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,236E-04 7,366E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 5,236E-04 7,324E-03 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 1,000 5,236E-04 7,281E-03 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 1,000 5,236E-04 7,239E-03 ! smooth muscle tissue development GO:0048745 28 5 1,000 5,236E-04 7,198E-03 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 1,000 5,236E-04 7,157E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 5,236E-04 7,117E-03 ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 5,236E-04 7,077E-03 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 1,000 5,236E-04 7,037E-03 ! valine metabolic process GO:0006573 10 5 1,000 5,236E-04 6,998E-03 ! muscle cell migration GO:0014812 8 5 1,000 5,236E-04 6,959E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 5,236E-04 6,921E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 5,236E-04 6,883E-03 ! peptidyl-histidine phosphorylation GO:0018106 9 5 1,000 5,236E-04 6,846E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 5,236E-04 6,809E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 5,236E-04 6,772E-03 ! forebrain morphogenesis GO:0048853 13 5 1,000 5,236E-04 6,736E-03 ! B cell homeostasis GO:0001782 13 5 1,000 5,236E-04 6,7E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 5,236E-04 6,665E-03 ! regulation of sensory perception GO:0051931 7 5 1,000 5,236E-04 6,63E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 5,236E-04 6,595E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 5,236E-04 6,561E-03 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 5,236E-04 6,527E-03 GO:0048103|somatic stem cell division, ! embryonic skeletal system development GO:0048706 85 51 3,000 5,291E-04 6,562E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 3,000 5,291E-04 6,528E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of chemotaxis GO:0050920 40 22 2,000 5,344E-04 6,56E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 5,344E-04 6,527E-03 ! apoptotic nuclear changes GO:0030262 32 22 2,000 5,344E-04 6,494E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 2,000 5,344E-04 6,461E-03 ! regulation of muscle contraction GO:0006937 81 52 3,000 5,699E-04 6,856E-03 ! cartilage development GO:0051216 90 52 3,000 5,699E-04 6,822E-03 ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 6,113E-04 7,281E-03 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 2,000 6,113E-04 7,245E-03 ! regulation of membrane potential GO:0042391 164 93 4,000 6,13E-04 7,23E-03 ! regulation of behavior GO:0050795 43 24 2,000 6,948E-04 8,155E-03 ! pallium development GO:0021543 49 24 2,000 6,948E-04 8,115E-03 ! protein tetramerization GO:0051262 52 24 2,000 6,948E-04 8,076E-03 ! positive regulation of caspase activity GO:0043280 95 55 3,000 7,058E-04 8,164E-03 GO:0010952|positive regulation of peptidase activity, ! aging GO:0007568 103 55 3,000 7,058E-04 8,125E-03 ! negative regulation of cell motion GO:0051271 134 55 3,000 7,058E-04 8,086E-03 ! regulation of DNA metabolic process GO:0051052 178 97 4,000 7,425E-04 8,467E-03 ! regulation of DNA replication GO:0006275 101 56 3,000 7,558E-04 8,577E-03 ! positive regulation of organelle organization GO:0010638 100 56 3,000 7,558E-04 8,537E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 1,000 7,815E-04 8,787E-03 ! embryonic hemopoiesis GO:0035162 14 6 1,000 7,815E-04 8,746E-03 ! activation of MAPKKK activity GO:0000185 12 6 1,000 7,815E-04 8,706E-03 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 1,000 7,815E-04 8,665E-03 ! hyperosmotic response GO:0006972 9 6 1,000 7,815E-04 8,626E-03 ! vascular smooth muscle contraction GO:0014829 13 6 1,000 7,815E-04 8,586E-03 ! positive regulation of muscle hypertrophy GO:0014742 10 6 1,000 7,815E-04 8,547E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! attachment of GPI anchor to protein GO:0016255 15 6 1,000 7,815E-04 8,509E-03 ! male sex determination GO:0030238 15 6 1,000 7,815E-04 8,47E-03 ! establishment of spindle localization GO:0051293 12 6 1,000 7,815E-04 8,432E-03 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 8 6 1,000 7,815E-04 8,395E-03 ! astrocyte development GO:0014002 15 6 1,000 7,815E-04 8,357E-03 ! Schwann cell development GO:0014044 15 6 1,000 7,815E-04 8,32E-03 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 7,815E-04 8,284E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 7,815E-04 8,247E-03 GO:0043011|myeloid dendritic cell differentiation, ! progesterone metabolic process GO:0042448 10 6 1,000 7,815E-04 8,211E-03 ! triglyceride catabolic process GO:0019433 10 6 1,000 7,815E-04 8,176E-03 ! negative regulation of B cell activation GO:0050869 13 6 1,000 7,815E-04 8,14E-03 ! myelination GO:0042552 45 25 2,000 7,854E-04 8,145E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 2,000 7,854E-04 8,11E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 2,000 7,854E-04 8,075E-03 ! cell cycle arrest GO:0007050 213 100 4,000 8,522E-04 8,726E-03 ! embryonic pattern specification GO:0009880 44 26 2,000 8,83E-04 9,002E-03 ! positive regulation of JUN kinase activity GO:0043507 51 26 2,000 8,83E-04 8,964E-03 ! skeletal system morphogenesis GO:0048705 105 59 3,000 9,207E-04 9,307E-03 ! DNA catabolic process GO:0006308 86 59 3,000 9,207E-04 9,268E-03 ! regulation of heart contraction GO:0008016 110 60 3,000 9,808E-04 9,833E-03 ! protein amino acid autophosphorylation GO:0046777 141 60 3,000 9,808E-04 9,792E-03 ! kidney development GO:0001822 122 60 3,000 9,808E-04 9,752E-03 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 9,881E-04 9,783E-03 ! mitochondrial membrane organization GO:0007006 57 27 2,000 9,881E-04 9,743E-03 ! regulation of chromosome organization GO:0033044 42 27 2,000 9,881E-04 9,703E-03 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 9,881E-04 9,664E-03 ! regulation of helicase activity GO:0051095 15 7 1,000 1,089E-03 0,01060677 ! regulation of lipid kinase activity GO:0043550 13 7 1,000 1,089E-03 0,010564 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 1,089E-03 0,01052158 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 1,000 1,089E-03 0,01047949 ! oxaloacetate metabolic process GO:0006107 10 7 1,000 1,089E-03 0,01043774 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 1,089E-03 0,01039632 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 1,000 1,089E-03 0,01035523 ! positive regulation of heart rate GO:0010460 10 7 1,000 1,089E-03 0,01031446 ! adrenal gland development GO:0030325 17 7 1,000 1,089E-03 0,01027401 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 1,000 1,089E-03 0,01023388 ! regulation of granule cell precursor proliferation GO:0021936 13 7 1,000 1,089E-03 0,01019406 GO:0021940|positive regulation of granule cell precursor proliferation, ! phasic smooth muscle contraction GO:0014821 12 7 1,000 1,089E-03 0,01015455 ! glycerol ether catabolic process GO:0044269 12 7 1,000 1,089E-03 0,01011534 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 1,000 1,089E-03 0,01007643 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 1,089E-03 0,01003783 ! cranial nerve morphogenesis GO:0021602 11 7 1,000 1,089E-03 1E-02 ! transcription termination GO:0006353 13 7 1,000 1,089E-03 9,961E-03 ! response to tumor cell GO:0002347 13 7 1,000 1,089E-03 9,924E-03 ! regulation of respiratory burst GO:0060263 11 7 1,000 1,089E-03 9,886E-03 ! peptidyl-histidine modification GO:0018202 16 7 1,000 1,089E-03 9,849E-03 ! diuresis GO:0030146 12 7 1,000 1,089E-03 9,812E-03 GO:0030147|natriuresis, ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 1,089E-03 9,776E-03 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 1,000 1,089E-03 9,739E-03 ! positive regulation of smooth muscle contraction GO:0045987 10 7 1,000 1,089E-03 9,703E-03 ! negative regulation of protein modification process GO:0031400 60 28 2,000 1,101E-03 9,772E-03 ! regulation of systemic arterial blood pressure GO:0003073 54 28 2,000 1,101E-03 9,737E-03 ! ear development GO:0043583 103 62 3,000 1,109E-03 9,777E-03 ! regulation of homeostatic process GO:0032844 134 62 3,000 1,109E-03 9,742E-03 ! steroid hormone receptor signaling pathway GO:0030518 129 63 3,000 1,178E-03 0,01030546 ! regulation of pH GO:0006885 43 29 2,000 1,221E-03 0,01064526 ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 1,221E-03 0,01060683 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 2,000 1,221E-03 0,01056867 ! cell junction assembly GO:0034329 78 30 2,000 1,35E-03 0,0116382 ! determination of left/right symmetry GO:0007368 47 30 2,000 1,35E-03 0,01159664 ! positive regulation of multicellular organism growth GO:0040018 51 30 2,000 1,35E-03 0,01155537 ! ensheathment of neurons GO:0007272 57 30 2,000 1,35E-03 0,01151439 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 1,35E-03 0,01147371 ! regulation of B cell activation GO:0050864 50 30 2,000 1,35E-03 0,01143331 ! actin filament organization GO:0007015 148 66 3,000 1,401E-03 0,0118283 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 1,445E-03 0,01215509 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 1,445E-03 0,01211274 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 1,000 1,445E-03 0,01207068 GO:0016446|somatic hypermutation of immunoglobulin genes, ! neutral lipid catabolic process GO:0046461 13 8 1,000 1,445E-03 0,01202891 ! signal peptide processing GO:0006465 12 8 1,000 1,445E-03 0,01198743 ! succinate metabolic process GO:0006105 14 8 1,000 1,445E-03 0,01194624 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,445E-03 0,01190533 ! glycerolipid catabolic process GO:0046503 13 8 1,000 1,445E-03 0,01186469 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 1,445E-03 0,01182434 ! pigment granule organization GO:0048753 16 8 1,000 1,445E-03 0,01178425 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,445E-03 0,01174444 ! astrocyte differentiation GO:0048708 18 8 1,000 1,445E-03 0,0117049 ! ER overload response GO:0006983 12 8 1,000 1,445E-03 0,01166562 ! regulation of pigmentation during development GO:0048070 24 8 1,000 1,445E-03 0,01162661 ! melanin metabolic process GO:0006582 15 8 1,000 1,445E-03 0,01158785 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 1,000 1,445E-03 0,01154935 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,445E-03 0,01151111 ! regulation of muscle hypertrophy GO:0014743 12 8 1,000 1,445E-03 0,01147312 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,445E-03 0,01143538 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 1,445E-03 0,01139789 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 1,000 1,445E-03 0,01136064 ! Schwann cell differentiation GO:0014037 19 8 1,000 1,445E-03 0,01132363 ! response to UV-B GO:0010224 16 8 1,000 1,445E-03 0,01128687 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 1,000 1,445E-03 0,01125034 ! DNA topological change GO:0006265 12 8 1,000 1,445E-03 0,01121405 ! regulation of cellular response to stress GO:0080135 128 67 3,000 1,482E-03 0,01146242 ! lung development GO:0030324 144 67 3,000 1,482E-03 0,01142568 ! determination of bilateral symmetry GO:0009855 49 31 2,000 1,486E-03 0,01142399 GO:0009799|determination of symmetry, ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 3,000 1,565E-03 0,01199422 ! protein maturation by peptide bond cleavage GO:0051605 105 68 3,000 1,565E-03 0,01195614 ! spindle organization GO:0007051 46 32 2,000 1,631E-03 0,01241927 ! metanephros development GO:0001656 74 32 2,000 1,631E-03 0,01238009 ! response to ionizing radiation GO:0010212 65 32 2,000 1,631E-03 0,01234116 ! peripheral nervous system development GO:0007422 64 32 2,000 1,631E-03 0,01230248 ! hindbrain development GO:0030902 61 32 2,000 1,631E-03 0,01226403 ! reproductive structure development GO:0048608 113 71 3,000 1,836E-03 0,01376199 ! B cell activation GO:0042113 160 71 3,000 1,836E-03 0,01371925 ! regulation of developmental growth GO:0048638 15 9 1,000 1,849E-03 0,01377122 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,849E-03 0,01372872 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 1,000 1,849E-03 0,01368648 GO:0010469|regulation of receptor activity, ! artery development GO:0060840 24 9 1,000 1,849E-03 0,01364449 GO:0048844|artery morphogenesis, ! regulation of glycolysis GO:0006110 21 9 1,000 1,849E-03 0,01360277 ! keratinocyte proliferation GO:0043616 14 9 1,000 1,849E-03 0,01356129 ! microtubule bundle formation GO:0001578 21 9 1,000 1,849E-03 0,01352007 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 1,000 1,849E-03 0,0134791 ! T cell selection GO:0045058 23 9 1,000 1,849E-03 0,01343838 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 1,000 1,849E-03 0,01339791 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,849E-03 0,01335767 GO:0006600|creatine metabolic process, ! behavioral fear response GO:0001662 22 9 1,000 1,849E-03 0,01331768 GO:0002209|behavioral defense response, ! motor axon guidance GO:0008045 16 9 1,000 1,849E-03 0,01327792 ! protein heterooligomerization GO:0051291 16 9 1,000 1,849E-03 0,01323841 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 1,849E-03 0,01319912 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 1,849E-03 0,01316007 ! renal water homeostasis GO:0003091 14 9 1,000 1,849E-03 0,01312125 ! induction of an organ GO:0001759 14 9 1,000 1,849E-03 0,01308266 ! regulation of telomere maintenance GO:0032204 14 9 1,000 1,849E-03 0,0130443 ! regulation of muscle adaptation GO:0043502 14 9 1,000 1,849E-03 0,01300615 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 3,000 1,933E-03 0,01355982 ! respiratory system development GO:0060541 153 72 3,000 1,933E-03 0,0135204 ! regulation of blood pressure GO:0008217 125 73 3,000 2,034E-03 0,01418214 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 2,000 2,118E-03 0,01472812 ! negative regulation of secretion GO:0051048 63 35 2,000 2,118E-03 0,01468568 ! embryonic skeletal system morphogenesis GO:0048704 59 35 2,000 2,118E-03 0,01464348 ! telencephalon development GO:0021537 68 35 2,000 2,118E-03 0,01460152 ! negative regulation of hydrolase activity GO:0051346 62 35 2,000 2,118E-03 0,0145598 ! calcium-mediated signaling GO:0019722 62 35 2,000 2,118E-03 0,01451832 ! regulation of microtubule-based process GO:0032886 78 35 2,000 2,118E-03 0,01447708 ! cell junction organization GO:0034330 86 36 2,000 2,298E-03 0,01566426 ! embryonic organ development GO:0048568 57 36 2,000 2,298E-03 0,01562001 ! negative regulation of cell activation GO:0050866 65 36 2,000 2,298E-03 0,01557601 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 1,000 2,3E-03 0,01554328 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 2,3E-03 0,01549974 ! positive regulation of heart contraction GO:0045823 16 10 1,000 2,3E-03 0,01545645 ! negative regulation of striated muscle development GO:0045843 19 10 1,000 2,3E-03 0,01541339 ! B cell proliferation GO:0042100 18 10 1,000 2,3E-03 0,01537058 ! epithelial cell development GO:0002064 20 10 1,000 2,3E-03 0,015328 ! positive regulation of muscle contraction GO:0045933 14 10 1,000 2,3E-03 0,01528566 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 2,3E-03 0,01524355 ! regulation of bone resorption GO:0045124 25 10 1,000 2,3E-03 0,01520167 ! brain morphogenesis GO:0048854 23 10 1,000 2,3E-03 0,01516002 ! alpha-beta T cell activation GO:0046631 23 10 1,000 2,3E-03 0,0151186 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 1,000 2,3E-03 0,0150774 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,3E-03 0,01503643 ! multicellular organismal water homeostasis GO:0050891 15 10 1,000 2,3E-03 0,01499568 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 2,3E-03 0,01495516 GO:0043470|regulation of carbohydrate catabolic process, ! oocyte development GO:0048599 17 10 1,000 2,3E-03 0,01491484 ! response to nicotine GO:0035094 20 10 1,000 2,3E-03 0,01487475 ! localization within membrane GO:0051668 20 10 1,000 2,3E-03 0,01483487 ! monovalent inorganic cation homeostasis GO:0055067 58 37 2,000 2,488E-03 0,01600328 ! regulation of protein stability GO:0031647 73 37 2,000 2,488E-03 0,0159606 ! blood coagulation GO:0007596 146 78 3,000 2,591E-03 0,01657771 GO:0050817|coagulation, ! negative regulation of organelle organization GO:0010639 161 78 3,000 2,591E-03 0,01653374 ! mitotic cell cycle checkpoint GO:0007093 76 38 2,000 2,686E-03 0,0170993 ! carbohydrate homeostasis GO:0033500 53 38 2,000 2,686E-03 0,01705419 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 67 38 2,000 2,686E-03 0,01700931 ! negative regulation of muscle development GO:0048635 20 11 1,000 2,797E-03 0,01766553 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 2,797E-03 0,01761929 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,797E-03 0,01757328 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 1,000 2,797E-03 0,01752752 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 2,797E-03 0,01748199 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 1,000 2,797E-03 0,0174367 ! regulation of intracellular pH GO:0051453 19 11 1,000 2,797E-03 0,01739165 ! negative regulation of ossification GO:0030279 26 11 1,000 2,797E-03 0,01734682 ! vasoconstriction GO:0042310 18 11 1,000 2,797E-03 0,01730223 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 1,000 2,797E-03 0,01725787 ! neuroblast proliferation GO:0007405 24 11 1,000 2,797E-03 0,01721373 ! oocyte differentiation GO:0009994 18 11 1,000 2,797E-03 0,01716982 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 1,000 2,797E-03 0,01712613 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 1,000 2,797E-03 0,01708266 ! embryonic gut development GO:0048566 15 11 1,000 2,797E-03 0,01703941 ! developmental induction GO:0031128 19 11 1,000 2,797E-03 0,01699638 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of embryonic development GO:0045995 27 11 1,000 2,797E-03 0,01695357 ! ear morphogenesis GO:0042471 60 39 2,000 2,895E-03 0,01749944 ! regulation of action potential in neuron GO:0019228 73 39 2,000 2,895E-03 0,01745558 ! regulation of T cell proliferation GO:0042129 71 41 2,000 3,341E-03 0,02009362 ! T cell differentiation GO:0030217 81 41 2,000 3,341E-03 0,02004351 ! dorsal/ventral pattern formation GO:0009953 68 41 2,000 3,341E-03 0,01999365 ! positive regulation of cellular catabolic process GO:0031331 31 12 1,000 3,341E-03 0,01994518 ! virus-host interaction GO:0019048 29 12 1,000 3,341E-03 0,01989581 ! protein complex disassembly GO:0043241 27 12 1,000 3,341E-03 0,01984669 GO:0043624|cellular protein complex disassembly, ! hippocampus development GO:0021766 26 12 1,000 3,341E-03 0,0197978 ! cytokine biosynthetic process GO:0042089 21 12 1,000 3,341E-03 0,01974916 ! positive regulation of cell growth GO:0030307 22 12 1,000 3,341E-03 0,01970076 ! fear response GO:0042596 26 12 1,000 3,341E-03 0,01965259 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 1,000 3,341E-03 0,01960466 ! cranial nerve development GO:0021545 20 12 1,000 3,341E-03 0,01955696 ! immunoglobulin production during immune response GO:0002381 23 12 1,000 3,341E-03 0,01950949 ! histone acetylation GO:0016573 26 12 1,000 3,341E-03 0,01946225 ! histone methylation GO:0016571 26 12 1,000 3,341E-03 0,01941524 ! gland morphogenesis GO:0022612 29 12 1,000 3,341E-03 0,01936845 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,341E-03 0,0193219 ! T cell homeostasis GO:0043029 25 12 1,000 3,341E-03 0,01927556 ! spleen development GO:0048536 22 12 1,000 3,341E-03 0,01922945 ! digestive tract morphogenesis GO:0048546 26 12 1,000 3,341E-03 0,01918355 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 3,341E-03 0,01913788 ! hemostasis GO:0007599 158 84 3,000 3,387E-03 0,01935931 ! response to reactive oxygen species GO:0000302 67 42 2,000 3,578E-03 0,02040176 ! negative regulation of protein complex disassembly GO:0043242 101 42 2,000 3,578E-03 0,02035353 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 2,000 3,826E-03 0,02171206 ! glucose transport GO:0015758 65 43 2,000 3,826E-03 0,02166097 ! positive regulation of response to external stimulus GO:0032103 77 43 2,000 3,826E-03 0,02161013 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 3,826E-03 0,02155952 ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 1,000 3,929E-03 0,02208825 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 3,929E-03 0,02203676 ! response to X-ray GO:0010165 25 13 1,000 3,929E-03 0,02198551 ! cytokine metabolic process GO:0042107 22 13 1,000 3,929E-03 0,0219345 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 3,929E-03 0,02188373 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 3,929E-03 0,02183319 ! regulation of cellular pH GO:0030641 22 13 1,000 3,929E-03 0,02178288 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 3,929E-03 0,02173281 ! positive regulation of Ras GTPase activity GO:0032320 35 13 1,000 3,929E-03 0,02168296 ! positive regulation of protein modification process GO:0031401 136 88 3,000 4,002E-03 0,02203643 ! hexose transport GO:0008645 67 44 2,000 4,084E-03 0,02243576 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 2,000 4,084E-03 0,02238465 ! double-strand break repair GO:0006302 81 44 2,000 4,084E-03 0,02233378 ! B cell differentiation GO:0030183 107 44 2,000 4,084E-03 0,02228313 ! cell growth GO:0016049 84 45 2,000 4,353E-03 0,02369385 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 4,562E-03 0,02477769 ! positive regulation of GTPase activity GO:0043547 36 14 1,000 4,562E-03 0,02472188 ! hair follicle morphogenesis GO:0031069 26 14 1,000 4,562E-03 0,02466632 ! palate development GO:0060021 31 14 1,000 4,562E-03 0,02461102 ! regulation of heart rate GO:0002027 24 14 1,000 4,562E-03 0,02455596 ! negative regulation of caspase activity GO:0043154 22 14 1,000 4,562E-03 0,02450115 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 4,562E-03 0,02444658 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 1,000 4,562E-03 0,02439225 ! negative regulation of protein import into nucleus GO:0042308 30 14 1,000 4,562E-03 0,02433817 ! T cell differentiation in the thymus GO:0033077 31 14 1,000 4,562E-03 0,02428432 ! cAMP biosynthetic process GO:0006171 23 14 1,000 4,562E-03 0,02423072 ! regulation of gene-specific transcription GO:0032583 96 46 2,000 4,632E-03 0,02454552 ! epidermal cell differentiation GO:0009913 68 46 2,000 4,632E-03 0,02449157 ! positive regulation of defense response GO:0031349 76 47 2,000 4,921E-03 0,0259651 ! JNK cascade GO:0007254 91 47 2,000 4,921E-03 0,02590829 ! female pregnancy GO:0007565 164 94 3,000 5,06E-03 0,02658139 ! regulation of T cell activation GO:0050863 158 94 3,000 5,06E-03 0,02652348 ! mitochondrial transport GO:0006839 82 48 2,000 5,221E-03 0,02730915 ! regulation of inflammatory response GO:0050727 75 48 2,000 5,221E-03 0,02724991 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 5,239E-03 0,0272825 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 5,239E-03 0,02722358 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 5,239E-03 0,02716491 ! G1/S transition checkpoint GO:0031575 40 15 1,000 5,239E-03 0,02710649 ! water homeostasis GO:0030104 27 15 1,000 5,239E-03 0,02704832 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 1,000 5,239E-03 0,0269904 ! lymphocyte homeostasis GO:0002260 30 15 1,000 5,239E-03 0,02693273 ! forebrain development GO:0030900 188 95 3,000 5,253E-03 0,02694664 ! leukocyte differentiation GO:0002521 202 96 3,000 5,45E-03 0,02790074 ! regulation of action potential GO:0001508 95 49 2,000 5,532E-03 0,02825964 ! regulation of protein complex disassembly GO:0043244 113 49 2,000 5,532E-03 0,02819977 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 2,000 5,532E-03 0,02814015 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 5,532E-03 0,02808079 ! regulation of protein localization GO:0032880 176 97 3,000 5,653E-03 0,02863268 ! histone modification GO:0016570 91 50 2,000 5,854E-03 0,02958945 ! negative regulation of immune system process GO:0002683 95 50 2,000 5,854E-03 0,02952742 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 5,959E-03 0,02999199 ! G1 phase of mitotic cell cycle GO:0000080 35 16 1,000 5,959E-03 0,02992938 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 5,959E-03 0,02986703 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 5,959E-03 0,02980493 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 1,000 5,959E-03 0,0297431 ! startle response GO:0001964 28 16 1,000 5,959E-03 0,02968152 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 1,000 5,959E-03 0,02962019 ! response to osmotic stress GO:0006970 25 16 1,000 5,959E-03 0,02955912 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 5,959E-03 0,0294983 ! defense response to virus GO:0051607 37 16 1,000 5,959E-03 0,02943773 ! epithelial tube morphogenesis GO:0060562 98 51 2,000 6,187E-03 0,03050268 ! covalent chromatin modification GO:0016569 101 52 2,000 6,531E-03 0,03213232 ! metencephalon development GO:0022037 30 17 1,000 6,721E-03 0,03299978 ! negative regulation of hormone secretion GO:0046888 25 17 1,000 6,721E-03 0,03293257 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 6,721E-03 0,03286564 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 1,000 6,721E-03 0,03279897 GO:0019692|deoxyribose phosphate metabolic process, ! signal complex assembly GO:0007172 41 17 1,000 6,721E-03 0,03273258 ! glial cell development GO:0021782 27 17 1,000 6,721E-03 0,03266645 ! limbic system development GO:0021761 36 17 1,000 6,721E-03 0,03260059 ! regulation of muscle cell differentiation GO:0051147 33 17 1,000 6,721E-03 0,032535 ! negative regulation of peptidase activity GO:0010466 27 17 1,000 6,721E-03 0,03246967 ! regulation of viral genome replication GO:0045069 28 17 1,000 6,721E-03 0,0324046 ! regulation of survival gene product expression GO:0045884 33 17 1,000 6,721E-03 0,03233979 ! regulation of protein binding GO:0043393 33 17 1,000 6,721E-03 0,03227524 ! branched chain family amino acid metabolic process GO:0009081 33 17 1,000 6,721E-03 0,03221094 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 6,721E-03 0,03214691 ! activation of phospholipase C activity GO:0007202 103 54 2,000 7,252E-03 0,03461976 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 2,000 7,252E-03 0,0345512 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 7,525E-03 0,03577888 ! response to retinoic acid GO:0032526 26 18 1,000 7,525E-03 0,03570831 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 1,000 7,525E-03 0,03563802 ! peptide biosynthetic process GO:0043043 24 18 1,000 7,525E-03 0,035568 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 7,525E-03 0,03549826 ! nerve development GO:0021675 28 18 1,000 7,525E-03 0,03542879 ! positive regulation of phospholipase activity GO:0010518 104 55 2,000 7,63E-03 0,03585356 ! regulation of multicellular organism growth GO:0040014 85 55 2,000 7,63E-03 0,03578367 ! nucleotide-excision repair GO:0006289 83 56 2,000 8,019E-03 0,03753535 ! protein secretion GO:0009306 39 19 1,000 8,37E-03 0,03910151 ! positive regulation of hormone secretion GO:0046887 32 19 1,000 8,37E-03 0,03902573 ! lipid phosphorylation GO:0046834 35 19 1,000 8,37E-03 0,03895024 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 8,37E-03 0,03887505 ! forelimb morphogenesis GO:0035136 32 19 1,000 8,37E-03 0,03880015 ! cerebral cortex development GO:0021987 36 19 1,000 8,37E-03 0,03872553 ! pigmentation during development GO:0048066 41 19 1,000 8,37E-03 0,0386512 ! response to vitamin A GO:0033189 27 19 1,000 8,37E-03 0,03857716 ! neuromuscular junction development GO:0007528 34 19 1,000 8,37E-03 0,0385034 ! visual learning GO:0008542 36 19 1,000 8,37E-03 0,03842992 ! cellular pigmentation GO:0033059 36 19 1,000 8,37E-03 0,03835672 ! G1 phase GO:0051318 40 19 1,000 8,37E-03 0,0382838 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 1,000 8,37E-03 0,03821115 ! peptide hormone secretion GO:0030072 31 19 1,000 8,37E-03 0,03813878 ! regulation of bone remodeling GO:0046850 137 57 2,000 8,419E-03 0,03829298 ! regulation of phospholipase activity GO:0010517 106 57 2,000 8,419E-03 0,03822073 ! regulation of tissue remodeling GO:0034103 140 58 2,000 8,832E-03 0,04001626 ! positive regulation of lipase activity GO:0060193 108 58 2,000 8,832E-03 0,03994104 ! protein amino acid acetylation GO:0006473 39 20 1,000 9,255E-03 0,04177833 ! cAMP metabolic process GO:0046058 36 20 1,000 9,255E-03 0,04170009 ! response to vitamin GO:0033273 31 20 1,000 9,255E-03 0,04162215 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 9,255E-03 0,04154449 GO:0010675|regulation of cellular carbohydrate metabolic process, ! C21-steroid hormone metabolic process GO:0008207 33 20 1,000 9,255E-03 0,04146713 ! DNA duplex unwinding GO:0032508 31 20 1,000 9,255E-03 0,04139005 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 1,000 9,255E-03 0,04131326 ! D-ribose metabolic process GO:0006014 29 20 1,000 9,255E-03 0,04123676 ! body fluid secretion GO:0007589 31 20 1,000 9,255E-03 0,04116053 ! peptide secretion GO:0002790 35 20 1,000 9,255E-03 0,04108459 ! camera-type eye morphogenesis GO:0048593 42 20 1,000 9,255E-03 0,04100893 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 1,000 9,255E-03 0,04093355 ! negative regulation of translation GO:0017148 29 20 1,000 9,255E-03 0,04085844 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 9,255E-03 0,04078361 ! negative regulation of response to stimulus GO:0048585 100 60 2,000 9,691E-03 0,0426254 ! hormone secretion GO:0046879 38 21 1,000 0,01018051 0,04469765 ! hindlimb morphogenesis GO:0035137 43 21 1,000 0,01018051 0,04461623 ! ovarian follicle development GO:0001541 35 21 1,000 0,01018051 0,04453511 ! smooth muscle contraction GO:0006939 46 21 1,000 0,01018051 0,04445429 ! cellular macromolecular complex disassembly GO:0034623 43 21 1,000 0,01018051 0,04437375 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 1,000 0,01018051 0,04429351 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 1,000 0,01018051 0,04421356 ! oogenesis GO:0048477 36 21 1,000 0,01018051 0,0441339 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 0,01018051 0,04405452 ! response to cytokine stimulus GO:0034097 63 21 1,000 0,01018051 0,04397543 ! viral reproductive process GO:0022415 126 62 2,000 0,01059716 0,04569314 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 1,000 0,01114512 0,04796988 ! regeneration GO:0031099 41 22 1,000 0,01114512 0,04788422 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 0,01114512 0,04779887 ! deoxyribonucleotide metabolic process GO:0009262 32 22 1,000 0,01114512 0,04771382 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 0,01114512 0,04762907 ! ureteric bud development GO:0001657 43 22 1,000 0,01114512 0,04754462 ! positive regulation of cytoskeleton organization GO:0051495 48 22 1,000 0,01114512 0,04746047 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 0,01114512 0,04737662 ! positive regulation of B cell activation GO:0050871 38 22 1,000 0,01114512 0,04729306 ! activation of JUN kinase activity GO:0007257 42 22 1,000 0,01114512 0,0472098 ! somatic diversification of immunoglobulins GO:0016445 50 22 1,000 0,01114512 0,04712683 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 0,01114512 0,04704415 ! germ cell development GO:0007281 118 65 2,000 0,01204589 0,05075728 ! positive regulation of DNA replication GO:0045740 43 23 1,000 0,01214835 0,05109952 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 1,000 0,01214835 0,05101034 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 0,01214835 0,05092147 ! myeloid leukocyte differentiation GO:0002573 40 23 1,000 0,01214835 0,05083291 ! regulation of anti-apoptosis GO:0045767 53 23 1,000 0,01214835 0,05074466 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 1,000 0,01214835 0,05065671 ! visual behavior GO:0007632 42 23 1,000 0,01214835 0,05056907 ! response to ethanol GO:0045471 46 23 1,000 0,01214835 0,05048173 ! sex determination GO:0007530 47 23 1,000 0,01214835 0,05039469 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 0,01214835 0,05030796 ! regulation of viral reproduction GO:0050792 38 23 1,000 0,01214835 0,05022152 ! hormone transport GO:0009914 40 23 1,000 0,01214835 0,05013537 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 1,000 0,01214835 0,05004953 ! extracellular matrix organization GO:0030198 133 66 2,000 0,01255278 0,05162735 ! protein import into nucleus, translocation GO:0000060 46 24 1,000 0,01318957 0,05415378 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 0,01318957 0,05406153 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 1,000 0,01318957 0,05396959 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 52 24 1,000 0,01318957 0,05387796 ! spinal cord development GO:0021510 47 24 1,000 0,01318957 0,05378664 ! multicellular organismal response to stress GO:0033555 49 24 1,000 0,01318957 0,05369563 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 0,01318957 0,05360493 ! regulation of alpha-beta T cell activation GO:0046634 42 24 1,000 0,01318957 0,05351453 ! lymphocyte proliferation GO:0046651 48 24 1,000 0,01318957 0,05342444 ! membrane depolarization GO:0051899 39 24 1,000 0,01318957 0,05333465 ! pentose metabolic process GO:0019321 35 24 1,000 0,01318957 0,05324516 ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 0,01318957 0,05315597 ! leukocyte homeostasis GO:0001776 44 24 1,000 0,01318957 0,05306708 ! viral reproduction GO:0016032 134 68 2,000 0,01360281 0,05463833 ! regulation of lipase activity GO:0060191 130 68 2,000 0,01360281 0,05454726 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 1,000 0,0142682 0,05712029 ! dicarboxylic acid metabolic process GO:0043648 42 25 1,000 0,0142682 0,05702541 ! protein amino acid alkylation GO:0008213 53 25 1,000 0,0142682 0,05693084 GO:0006479|protein amino acid methylation, ! vasculogenesis GO:0001570 46 25 1,000 0,0142682 0,05683658 ! regulation of smooth muscle contraction GO:0006940 43 25 1,000 0,0142682 0,05674264 ! negative regulation of DNA replication GO:0008156 42 25 1,000 0,0142682 0,056649 ! response to starvation GO:0042594 42 25 1,000 0,0142682 0,05655567 ! osteoblast differentiation GO:0001649 60 25 1,000 0,0142682 0,05646266 ! response to endoplasmic reticulum stress GO:0034976 43 25 1,000 0,0142682 0,05636994 ! neural crest cell development GO:0014032 54 25 1,000 0,0142682 0,05627753 GO:0014033|neural crest cell differentiation, ! interaction with host GO:0051701 62 25 1,000 0,0142682 0,05618542 ! somitogenesis GO:0001756 43 25 1,000 0,0142682 0,05609362 ! immunoglobulin production GO:0002377 55 25 1,000 0,0142682 0,05600211 GO:0002440|production of molecular mediator of immune response, ! cellular response to nutrient levels GO:0031669 41 25 1,000 0,0142682 0,0559109 ! neural tube closure GO:0001843 49 25 1,000 0,0142682 0,05581999 GO:0060606|tube closure, ! liver development GO:0001889 53 25 1,000 0,0142682 0,05572937 ! appendage morphogenesis GO:0035107 135 70 2,000 0,0147014 0,0573283 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 136 71 2,000 0,01526899 0,05944527 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 2,000 0,01526899 0,05934924 ! molting cycle process GO:0022404 50 26 1,000 0,01538363 0,05969842 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! tube lumen formation GO:0035148 50 26 1,000 0,01538363 0,05960229 ! macromolecular complex disassembly GO:0032984 53 26 1,000 0,01538363 0,05950646 ! regulation of transcription factor import into nucleus GO:0042990 54 26 1,000 0,01538363 0,05941095 ! regulation of endothelial cell proliferation GO:0001936 57 26 1,000 0,01538363 0,05931574 ! cellular response to oxidative stress GO:0034599 39 26 1,000 0,01538363 0,05922083 ! somatic diversification of immune receptors GO:0002200 56 26 1,000 0,01538363 0,05912623 ! leukocyte proliferation GO:0070661 52 26 1,000 0,01538363 0,05903193 GO:0032943|mononuclear cell proliferation, ! phosphoinositide metabolic process GO:0030384 128 72 2,000 0,01584881 0,06072011 ! carbohydrate transport GO:0008643 110 72 2,000 0,01584881 0,06062358 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 0,01653528 0,06314901 ! protein amino acid acylation GO:0043543 55 27 1,000 0,01653528 0,06304893 ! male gonad development GO:0008584 44 27 1,000 0,01653528 0,06294917 ! response to toxin GO:0009636 47 27 1,000 0,01653528 0,06284973 ! primary neural tube formation GO:0014020 51 27 1,000 0,01653528 0,06275059 ! base-excision repair GO:0006284 41 27 1,000 0,01653528 0,06265177 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 1,000 0,01653528 0,06255326 ! negative regulation of neuron differentiation GO:0045665 42 27 1,000 0,01653528 0,06245506 ! regulation of transcription factor activity GO:0051090 126 74 2,000 0,01704525 0,06428036 GO:0090046|regulation of transcription regulator activity, ! lymphocyte differentiation GO:0030098 167 75 2,000 0,01766191 0,06650166 ! dendrite development GO:0016358 59 28 1,000 0,01772255 0,06662571 ! ER-nuclear signaling pathway GO:0006984 48 28 1,000 0,01772255 0,06652177 ! positive regulation of T cell differentiation GO:0045582 42 28 1,000 0,01772255 0,06641816 ! regulation of catabolic process GO:0009894 161 76 2,000 0,01829089 0,06844151 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 0,01893221 0,0707312 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 0,01894488 0,07066879 ! respiratory gaseous exchange GO:0007585 57 29 1,000 0,01894488 0,0705594 ! response to organic cyclic substance GO:0014070 55 29 1,000 0,01894488 0,07045034 ! tissue homeostasis GO:0001894 48 29 1,000 0,01894488 0,07034162 GO:0048871|multicellular organismal homeostasis, ! protein oligomerization GO:0051259 139 78 2,000 0,01958587 0,07260955 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 1,000 0,02020168 0,07477731 ! negative regulation of protein kinase cascade GO:0010741 68 30 1,000 0,02020168 0,07466244 ! eye morphogenesis GO:0048592 60 30 1,000 0,02020168 0,07454793 ! response to heat GO:0009408 50 30 1,000 0,02020168 0,07443377 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 2,000 0,02025188 0,07450464 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 2,000 0,02025188 0,07439089 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 1,000 0,02149241 0,07882734 ! GPI anchor biosynthetic process GO:0006506 53 31 1,000 0,02149241 0,07870736 ! ovulation cycle process GO:0022602 49 31 1,000 0,02149241 0,07858775 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 1,000 0,02149241 0,07846849 ! peptide transport GO:0015833 55 31 1,000 0,02149241 0,0783496 ! triglyceride metabolic process GO:0006641 43 31 1,000 0,02149241 0,07823107 ! iron ion homeostasis GO:0055072 54 31 1,000 0,02149241 0,0781129 ! myeloid leukocyte activation GO:0002274 49 31 1,000 0,02149241 0,07799508 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 0,02149241 0,07787762 GO:0043433|negative regulation of transcription factor activity, ! T cell activation GO:0042110 168 81 2,000 0,02162101 0,07822579 ! regulation of neuron differentiation GO:0045664 167 81 2,000 0,02162101 0,07810833 ! regulation of cAMP biosynthetic process GO:0030817 161 82 2,000 0,02232413 0,08052751 ! response to drug GO:0042493 143 82 2,000 0,02232413 0,08040696 ! response to nutrient GO:0007584 125 82 2,000 0,02232413 0,08028677 ! response to hydrogen peroxide GO:0042542 50 32 1,000 0,02281649 0,08193505 ! GPI anchor metabolic process GO:0006505 56 32 1,000 0,02281649 0,08181295 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,02281649 0,0816912 ! regulation of protein import into nucleus GO:0042306 63 32 1,000 0,02281649 0,08156982 ! ovulation cycle GO:0042698 51 32 1,000 0,02281649 0,08144879 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 1,000 0,02281649 0,08132813 ! positive regulation of catabolic process GO:0009896 64 32 1,000 0,02281649 0,08120782 ! regulation of cAMP metabolic process GO:0030814 168 84 2,000 0,02376747 0,08446755 ! regulation of ligase activity GO:0051340 142 84 2,000 0,02376747 0,08434297 ! post-embryonic development GO:0009791 69 33 1,000 0,02417339 0,0856571 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,02417339 0,08553114 ! cell fate specification GO:0001708 52 33 1,000 0,02417339 0,08540554 ! adult locomotory behavior GO:0008344 59 33 1,000 0,02417339 0,08528031 ! negative regulation of protein transport GO:0051224 69 33 1,000 0,02417339 0,08515545 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,02450769 0,08620688 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 1,000 0,02556255 0,08978611 ! glial cell differentiation GO:0010001 63 34 1,000 0,02556255 0,08965523 ! mismatch repair GO:0006298 46 34 1,000 0,02556255 0,08952472 ! spermatid development GO:0007286 63 34 1,000 0,02556255 0,0893946 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 1,000 0,02556255 0,08926486 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 1,000 0,02556255 0,08913549 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 2,000 0,02602521 0,09061744 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of protein transport GO:0051223 154 87 2,000 0,02602521 0,09048649 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 155 88 2,000 0,02680248 0,0930545 ! regulation of neurological system process GO:0031644 148 88 2,000 0,02680248 0,09292041 ! negative regulation of DNA metabolic process GO:0051053 61 35 1,000 0,02698343 0,09341313 ! negative regulation of cell adhesion GO:0007162 81 35 1,000 0,02698343 0,09327892 ! odontogenesis GO:0042476 66 35 1,000 0,02698343 0,09314509 ! female gonad development GO:0008585 58 35 1,000 0,02698343 0,09301164 ! neutral lipid metabolic process GO:0006638 50 35 1,000 0,02698343 0,09287858 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 59 35 1,000 0,02698343 0,09274589 ! neural tube formation GO:0001841 67 35 1,000 0,02698343 0,09261359 ! ossification GO:0001503 188 90 2,000 0,028394 0,09731618 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 2,000 0,028394 0,09717775 ! sex differentiation GO:0007548 145 90 2,000 0,028394 0,09703972 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,0284355 0,0970437 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 1,000 0,0284355 0,09690625 ! positive regulation of cell development GO:0010720 80 36 1,000 0,0284355 0,09676918 ! regulation of proteolysis GO:0030162 72 36 1,000 0,0284355 0,0966325 ! hormone biosynthetic process GO:0042446 57 36 1,000 0,0284355 0,09649621 ! bone development GO:0060348 189 91 2,000 0,02920821 0,09897882 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 1,000 0,02991823 0,10124229 ! sister chromatid segregation GO:0000819 58 37 1,000 0,02991823 0,1011001 ! negative regulation of DNA binding GO:0043392 68 37 1,000 0,02991823 0,10095831 ! cyclic nucleotide metabolic process GO:0009187 63 37 1,000 0,02991823 0,10081691 ! glycerol ether metabolic process GO:0006662 53 37 1,000 0,02991823 0,1006759 ! pigment metabolic process GO:0042440 80 37 1,000 0,02991823 0,1005353 ! spermatid differentiation GO:0048515 66 37 1,000 0,02991823 0,10039508 ! regulation of defense response GO:0031347 149 92 2,000 0,03003471 0,10064556 ! regulation of nucleotide metabolic process GO:0006140 182 93 2,000 0,03087346 0,10331232 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,03143111 0,1050323 ! phosphoinositide biosynthetic process GO:0046489 67 38 1,000 0,03143111 0,10488663 ! development of primary female sexual characteristics GO:0046545 67 38 1,000 0,03143111 0,10474135 GO:0046660|female sex differentiation, ! embryonic epithelial tube formation GO:0001838 72 38 1,000 0,03143111 0,10459648 ! positive regulation of leukocyte proliferation GO:0070665 62 38 1,000 0,03143111 0,10445201 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 86 39 1,000 0,03297362 0,10942693 ! learning GO:0007612 77 39 1,000 0,03297362 0,10927621 ! organic ether metabolic process GO:0018904 55 39 1,000 0,03297362 0,1091259 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,03297362 0,108976 ! Rho protein signal transduction GO:0007266 74 39 1,000 0,03297362 0,10882651 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 1,000 0,03454524 0,11385733 ! regulation of hormone secretion GO:0046883 62 40 1,000 0,03454524 0,11370158 ! negative regulation of binding GO:0051100 72 40 1,000 0,03454524 0,11354625 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,03454524 0,11339134 ! cytokinesis GO:0000910 72 40 1,000 0,03454524 0,11323686 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,03599685 0,1178346 ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03599685 0,1176745 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,03599685 0,11751483 ! neuron fate determination GO:0048664 7 5 0,000 0,03599685 0,1173556 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03599685 0,11719679 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,03599685 0,11703842 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,03599685 0,11688047 ! polyol transport GO:0015791 12 5 0,000 0,03599685 0,11672295 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,03599685 0,11656586 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03599685 0,11640918 ! response to superoxide GO:0000303 10 5 0,000 0,03599685 0,11625293 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03599685 0,11609709 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,03599685 0,11594167 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,03599685 0,11578667 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03599685 0,11563208 ! female meiosis GO:0007143 7 5 0,000 0,03599685 0,11547791 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03599685 0,11532414 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03599685 0,11517079 ! cobalt ion transport GO:0006824 11 5 0,000 0,03599685 0,11501784 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,03599685 0,11486529 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,03599685 0,11471315 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,03599685 0,11456142 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03599685 0,11441008 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,03599685 0,11425914 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,03599685 0,1141086 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,03599685 0,11395846 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03599685 0,11380871 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,03599685 0,11365936 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,03599685 0,11351039 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03599685 0,11336182 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03599685 0,11321363 ! negative chemotaxis GO:0050919 14 5 0,000 0,03599685 0,11306584 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03599685 0,11291842 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03599685 0,11277139 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,03599685 0,11262475 ! behavioral response to pain GO:0048266 9 5 0,000 0,03599685 0,11247848 ! clathrin coat assembly GO:0048268 14 5 0,000 0,03599685 0,11233259 ! Notch receptor processing GO:0007220 8 5 0,000 0,03599685 0,11218709 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03599685 0,11204195 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03599685 0,1118972 ! micturition GO:0060073 9 5 0,000 0,03599685 0,11175281 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03599685 0,1116088 ! copulation GO:0007620 9 5 0,000 0,03599685 0,11146516 ! glial cell fate commitment GO:0021781 13 5 0,000 0,03599685 0,11132189 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,03599685 0,11117899 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03599685 0,11103645 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03599685 0,11089428 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03599685 0,11075247 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,03599685 0,11061102 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03599685 0,11046994 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03599685 0,11032921 ! grooming behavior GO:0007625 6 5 0,000 0,03599685 0,11018884 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03599685 0,11004883 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,03599685 0,10990918 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03599685 0,10976987 ! response to protozoan GO:0001562 10 5 0,000 0,03599685 0,10963092 ! lymph vessel development GO:0001945 10 5 0,000 0,03599685 0,10949233 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,03599685 0,10935408 ! endochondral ossification GO:0001958 16 5 0,000 0,03599685 0,10921618 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03599685 0,10907863 ! parathyroid gland development GO:0060017 13 5 0,000 0,03599685 0,10894142 ! anagen GO:0042640 6 5 0,000 0,03599685 0,10880456 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03599685 0,10866804 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,03599685 0,10853187 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,03599685 0,10839603 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,03599685 0,10826054 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,03599685 0,10812538 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,03599685 0,10799056 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03599685 0,10785608 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,03599685 0,10772193 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,03599685 0,10758811 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03599685 0,10745463 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,03599685 0,10732148 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03599685 0,10718865 ! histidine catabolic process GO:0006548 6 5 0,000 0,03599685 0,10705616 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03599685 0,10692399 ! microvillus organization GO:0032528 7 5 0,000 0,03599685 0,10679215 GO:0030033|microvillus assembly, ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,03599685 0,10666063 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03599685 0,10652944 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,03599685 0,10639856 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,03599685 0,10626801 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03599685 0,10613778 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,03599685 0,10600787 ! polyol catabolic process GO:0046174 7 5 0,000 0,03599685 0,10587828 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03599685 0,105749 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03599685 0,10562004 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03599685 0,10549139 ! mitochondrial fission GO:0000266 8 5 0,000 0,03599685 0,10536305 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,03599685 0,10523503 ! mRNA transcription GO:0009299 9 5 0,000 0,03599685 0,10510732 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,03599685 0,10497992 GO:0009253|peptidoglycan catabolic process, ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,03599685 0,10485282 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03599685 0,10472603 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03599685 0,10459955 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03599685 0,10447338 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03599685 0,10434751 ! response to food GO:0032094 6 5 0,000 0,03599685 0,10422194 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03599685 0,10409667 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,03599685 0,10397171 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03599685 0,10384704 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,03599685 0,10372267 ! forebrain neuron development GO:0021884 13 5 0,000 0,03599685 0,1035986 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03599685 0,10347483 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,03599685 0,10335135 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03599685 0,10322817 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03599685 0,10310527 GO:0009251|glucan catabolic process, ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03599685 0,10298268 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,03599685 0,10286037 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,03599685 0,10273835 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03599685 0,10261662 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,03599685 0,10249518 ! basic amino acid transport GO:0015802 11 5 0,000 0,03599685 0,10237403 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03599685 0,10225316 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,03599685 0,10213258 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03599685 0,10201229 ! depyrimidination GO:0045008 10 5 0,000 0,03599685 0,10189227 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03599685 0,10177254 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03599685 0,10165309 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,03599685 0,10153392 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,03599685 0,10141502 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03599685 0,10129641 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03599685 0,10117807 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,03599685 0,10106001 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,03599685 0,10094223 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03599685 0,10082472 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03599685 0,10070748 ! response to arsenic GO:0046685 10 5 0,000 0,03599685 0,10059051 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,03599685 0,10047382 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03599685 0,10035739 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,03599685 0,10024124 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,03599685 0,10012535 ! response to cadmium ion GO:0046686 7 5 0,000 0,03599685 0,10000974 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,03599685 0,09989438 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,03599685 0,0997793 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03599685 0,09966448 ! decidualization GO:0046697 11 5 0,000 0,03599685 0,09954992 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,03599685 0,09943563 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,03599685 0,09932159 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03599685 0,09920782 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03599685 0,09909431 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,03599685 0,09898106 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03599685 0,09886807 ! neural tube patterning GO:0021532 7 5 0,000 0,03599685 0,09875534 ! embryonic cleavage GO:0040016 6 5 0,000 0,03599685 0,09864286 ! peroxisome fission GO:0016559 5 5 0,000 0,03599685 0,09853064 ! histone demethylation GO:0016577 10 5 0,000 0,03599685 0,09841867 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,03599685 0,09830696 ! mitotic recombination GO:0006312 9 5 0,000 0,03599685 0,0981955 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03599685 0,09808429 ! metaphase plate congression GO:0051310 7 5 0,000 0,03599685 0,09797334 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03599685 0,09786263 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03599685 0,09775218 ! enteric nervous system development GO:0048484 8 5 0,000 0,03599685 0,09764197 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,03599685 0,09753202 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,03599685 0,09742231 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,03599685 0,09731284 ! muscle cell proliferation GO:0033002 11 5 0,000 0,03599685 0,09720363 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03599685 0,09709465 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,03599685 0,09698592 ! plasminogen activation GO:0031639 5 5 0,000 0,03599685 0,09687744 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,03599685 0,0967692 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03599685 0,0966612 ! metaphase GO:0051323 8 5 0,000 0,03599685 0,09655343 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,03599685 0,09644591 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03599685 0,09633863 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03599685 0,09623159 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03599685 0,09612478 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03599685 0,09601822 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03599685 0,09591188 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,03599685 0,09580579 ! response to redox state GO:0051775 5 5 0,000 0,03599685 0,09569992 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,03599685 0,09559429 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,03599685 0,0954889 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03599685 0,09538373 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,03599685 0,0952788 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03599685 0,0951741 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,03599685 0,09506963 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03599685 0,09496538 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,03599685 0,09486137 ! striatum development GO:0021756 9 5 0,000 0,03599685 0,09475758 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,03599685 0,09465402 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,03599685 0,09455069 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03599685 0,09444758 ! glial cell migration GO:0008347 11 5 0,000 0,03599685 0,0943447 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03599685 0,09424204 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03599685 0,0941396 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03599685 0,09403738 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03599685 0,09393539 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03599685 0,09383362 ! neuroprotection GO:0043526 6 5 0,000 0,03599685 0,09373207 ! neural plate development GO:0001840 8 5 0,000 0,03599685 0,09363074 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,03599685 0,09352962 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03599685 0,09342873 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,03599685 0,09332805 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,03599685 0,09322759 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03599685 0,09312734 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03599685 0,09302732 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03599685 0,0929275 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03599685 0,0928279 ! spindle assembly GO:0051225 6 5 0,000 0,03599685 0,09272851 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,03599685 0,09262934 GO:0016226|iron-sulfur cluster assembly, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03599685 0,09253037 ! drug metabolic process GO:0017144 6 5 0,000 0,03599685 0,09243162 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03599685 0,09233308 ! organ regeneration GO:0031100 7 5 0,000 0,03599685 0,09223475 ! carnitine metabolic process GO:0009437 7 5 0,000 0,03599685 0,09213663 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,03599685 0,09203871 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03599685 0,09194101 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 1,000 0,03614548 0,09222272 ! cellular amide metabolic process GO:0043603 67 41 1,000 0,03614548 0,09212503 ! gliogenesis GO:0042063 88 41 1,000 0,03614548 0,09202754 ! keratinocyte differentiation GO:0030216 62 41 1,000 0,03614548 0,09193026 ! female gamete generation GO:0007292 61 41 1,000 0,03614548 0,09183319 ! skeletal muscle tissue development GO:0007519 186 99 2,000 0,03616213 0,09177858 GO:0060538|skeletal muscle organ development, ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,03777384 0,09576802 GO:0090047|positive regulation of transcription regulator activity, ! regulation of tube size GO:0035150 71 42 1,000 0,03777384 0,09566721 GO:0050880|regulation of blood vessel size, ! regulation of intracellular protein transport GO:0033157 80 42 1,000 0,03777384 0,09556662 ! neuron migration GO:0001764 79 42 1,000 0,03777384 0,09546623 ! regulation of protein secretion GO:0050708 71 42 1,000 0,03777384 0,09536606 ! epithelial cell differentiation GO:0030855 79 43 1,000 0,03942982 0,0994425 ! receptor-mediated endocytosis GO:0006898 88 43 1,000 0,03942982 0,09933837 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 1,000 0,03942982 0,09923446 ! neural tube development GO:0021915 77 43 1,000 0,03942982 0,09913077 ! male sex differentiation GO:0046661 76 44 1,000 0,04111294 0,10325441 ! biopolymer methylation GO:0043414 84 44 1,000 0,04111294 0,10314674 ! JAK-STAT cascade GO:0007259 71 44 1,000 0,04111294 0,1030393 ! developmental growth GO:0048589 82 44 1,000 0,04111294 0,10293208 ! regulation of JAK-STAT cascade GO:0046425 70 45 1,000 0,04282271 0,1071013 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,04282271 0,10699008 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04303992 0,1074212 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04303992 0,10730988 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,04303992 0,1071988 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04303992 0,10708794 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04303992 0,10697731 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,04303992 0,10686691 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,04303992 0,10675674 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04303992 0,1066468 ! sleep GO:0030431 13 6 0,000 0,04303992 0,10653708 ! response to oxygen radical GO:0000305 11 6 0,000 0,04303992 0,10642758 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,04303992 0,10631831 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,04303992 0,10620927 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,04303992 0,10610045 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,04303992 0,10599185 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04303992 0,10588348 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,04303992 0,10577532 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,04303992 0,10566739 ! forebrain regionalization GO:0021871 8 6 0,000 0,04303992 0,10555967 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04303992 0,10545218 ! male meiosis GO:0007140 7 6 0,000 0,04303992 0,1053449 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04303992 0,10523784 ! response to zinc ion GO:0010043 9 6 0,000 0,04303992 0,105131 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04303992 0,10502438 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,04303992 0,10491797 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04303992 0,10481178 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04303992 0,1047058 ! malate metabolic process GO:0006108 11 6 0,000 0,04303992 0,10460004 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,04303992 0,10449449 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,04303992 0,10438915 ! protein refolding GO:0042026 15 6 0,000 0,04303992 0,10428403 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04303992 0,10417911 ! opsonization GO:0008228 8 6 0,000 0,04303992 0,10407441 ! mating behavior GO:0007617 7 6 0,000 0,04303992 0,10396992 ! neuron remodeling GO:0016322 15 6 0,000 0,04303992 0,10386564 ! erythrocyte maturation GO:0043249 7 6 0,000 0,04303992 0,10376156 ! equilibrioception GO:0050957 14 6 0,000 0,04303992 0,1036577 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,04303992 0,10355404 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,04303992 0,10345059 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04303992 0,10334734 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,04303992 0,10324431 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04303992 0,10314147 ! response to interferon-gamma GO:0034341 15 6 0,000 0,04303992 0,10303884 ! toxin metabolic process GO:0009404 11 6 0,000 0,04303992 0,10293642 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04303992 0,1028342 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04303992 0,10273218 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,04303992 0,10263037 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,04303992 0,10252875 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,04303992 0,10242734 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,04303992 0,10232613 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,04303992 0,10222511 ! thymic T cell selection GO:0045061 12 6 0,000 0,04303992 0,1021243 ! protein lipoylation GO:0009249 10 6 0,000 0,04303992 0,10202368 ! cysteine metabolic process GO:0006534 10 6 0,000 0,04303992 0,10192327 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04303992 0,10182305 ! glutamate catabolic process GO:0006538 10 6 0,000 0,04303992 0,10172302 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,04303992 0,1016232 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04303992 0,10152357 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,04303992 0,10142413 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,04303992 0,10132489 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04303992 0,10122584 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,04303992 0,10112699 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,04303992 0,10102833 ! urea metabolic process GO:0019627 7 6 0,000 0,04303992 0,10092986 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04303992 0,10083159 ! neutrophil activation GO:0042119 8 6 0,000 0,04303992 0,1007335 ! regulation of appetite GO:0032098 9 6 0,000 0,04303992 0,10063561 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04303992 0,1005379 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04303992 0,10044039 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04303992 0,10034306 ! neuron apoptosis GO:0051402 9 6 0,000 0,04303992 0,10024592 ! nucleoside salvage GO:0043174 9 6 0,000 0,04303992 0,10014897 GO:0006166|purine ribonucleoside salvage, ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,04303992 0,10005221 ! T cell mediated immunity GO:0002456 16 6 0,000 0,04303992 0,09995564 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04303992 0,09985925 GO:0010543|regulation of platelet activation, ! carnitine transport GO:0015879 10 6 0,000 0,04303992 0,09976304 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,04303992 0,09966702 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04303992 0,09957119 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,04303992 0,09947554 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,04303992 0,09938008 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,04303992 0,09928479 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04303992 0,09918969 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,04303992 0,09909477 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,04303992 0,09900004 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,04303992 0,09890548 ! monocyte differentiation GO:0030224 12 6 0,000 0,04303992 0,09881111 ! response to UV-C GO:0010225 11 6 0,000 0,04303992 0,09871691 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,04303992 0,09862289 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04303992 0,09852906 ! interaction with symbiont GO:0051702 13 6 0,000 0,04303992 0,0984354 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04303992 0,09834192 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04303992 0,09824861 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,04303992 0,09815549 ! response to copper ion GO:0046688 10 6 0,000 0,04303992 0,09806254 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,04303992 0,09796976 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,04303992 0,09787716 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04303992 0,09778474 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04303992 0,09769249 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,04303992 0,09760041 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,04303992 0,09750851 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04303992 0,09741678 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,04303992 0,09732522 ! hair follicle maturation GO:0048820 7 6 0,000 0,04303992 0,09723384 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04303992 0,09714263 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,04303992 0,09705158 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04303992 0,09696071 ! subpallium development GO:0021544 10 6 0,000 0,04303992 0,09687001 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,04303992 0,09677948 ! histone ubiquitination GO:0016574 8 6 0,000 0,04303992 0,09668911 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,04303992 0,09659892 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04303992 0,09650889 ! G2 phase GO:0051319 16 6 0,000 0,04303992 0,09641903 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,04303992 0,09632934 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04303992 0,09623981 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,04303992 0,09615045 ! membrane to membrane docking GO:0022614 14 6 0,000 0,04303992 0,09606126 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04303992 0,09597223 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,04303992 0,09588337 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04303992 0,09579467 ! receptor internalization GO:0031623 10 6 0,000 0,04303992 0,09570614 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,04303992 0,09561776 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,04303992 0,09552956 ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,04303992 0,09544151 ! protein deubiquitination GO:0016579 14 6 0,000 0,04303992 0,09535363 ! protein destabilization GO:0031648 9 6 0,000 0,04303992 0,0952659 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04303992 0,09517834 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,04303992 0,09509094 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04303992 0,09500371 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,04303992 0,09491663 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,04303992 0,09482971 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,04303992 0,09474294 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,04303992 0,09465634 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,04303992 0,0945699 ! determination of adult lifespan GO:0008340 15 6 0,000 0,04303992 0,09448361 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,04303992 0,09439748 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,04303992 0,09431151 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04303992 0,09422569 ! catecholamine transport GO:0051937 9 6 0,000 0,04303992 0,09414004 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,04303992 0,09405453 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04303992 0,09396918 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04303992 0,09388399 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,04303992 0,09379895 ! maternal placenta development GO:0001893 12 6 0,000 0,04303992 0,09371406 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,04303992 0,09362933 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04303992 0,09354475 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,04303992 0,09346032 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04303992 0,09337605 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,04303992 0,09329193 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,04303992 0,09320796 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 1,000 0,04455867 0,09641022 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 1,000 0,04455867 0,0963236 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,04632034 0,10004196 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,04632034 0,09995224 ! positive regulation of cyclase activity GO:0031281 103 47 1,000 0,04632034 0,09986268 ! methylation GO:0032259 90 47 1,000 0,04632034 0,09977328 ! morphogenesis of embryonic epithelium GO:0016331 91 48 1,000 0,04810726 0,10352959 ! positive regulation of lyase activity GO:0051349 104 48 1,000 0,04810726 0,10343707 ! protein amino acid lipidation GO:0006497 95 49 1,000 0,04991897 0,10723665 ! peptide metabolic process GO:0006518 76 49 1,000 0,04991897 0,10714099 ! response to temperature stimulus GO:0009266 76 49 1,000 0,04991897 0,1070455 ! immunoglobulin mediated immune response GO:0016064 83 49 1,000 0,04991897 0,10695017 GO:0019724|B cell mediated immunity, ! endocrine system development GO:0035270 104 49 1,000 0,04991897 0,10685502 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,04991897 0,10676004 ! tRNA transcription GO:0009304 14 7 0,000 0,05003175 0,10690622 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,05003175 0,10681136 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,05003175 0,10671667 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,05003175 0,10662214 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,05003175 0,10652779 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,05003175 0,1064336 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,05003175 0,10633958 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,05003175 0,10624572 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,05003175 0,10615203 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,05003175 0,1060585 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05003175 0,10596514 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,05003175 0,10587194 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,05003175 0,10577891 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05003175 0,10568604 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,05003175 0,10559333 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,05003175 0,10550079 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,05003175 0,10540841 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,05003175 0,10531619 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,05003175 0,10522413 ! glycolipid transport GO:0046836 10 7 0,000 0,05003175 0,10513223 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,05003175 0,10504049 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,05003175 0,10494891 ! neuron adhesion GO:0007158 12 7 0,000 0,05003175 0,10485749 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,05003175 0,10476623 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,05003175 0,10467513 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,05003175 0,10458419 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,05003175 0,1044934 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,05003175 0,10440278 ! mRNA stabilization GO:0048255 18 7 0,000 0,05003175 0,1043123 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 14 7 0,000 0,05003175 0,10422199 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,05003175 0,10413183 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,05003175 0,10404183 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05003175 0,10395199 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,05003175 0,10386229 ! lipoprotein transport GO:0042953 14 7 0,000 0,05003175 0,10377276 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05003175 0,10368338 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05003175 0,10359415 ! rhythmic behavior GO:0007622 15 7 0,000 0,05003175 0,10350507 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,05003175 0,10341615 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,05003175 0,10332738 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,05003175 0,10323876 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,05003175 0,1031503 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,05003175 0,10306199 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,05003175 0,10297382 ! mechanosensory behavior GO:0007638 14 7 0,000 0,05003175 0,10288581 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,05003175 0,10279795 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05003175 0,10271024 GO:0045911|positive regulation of DNA recombination, ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05003175 0,10262268 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05003175 0,10253526 ! spinal cord patterning GO:0021511 13 7 0,000 0,05003175 0,102448 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,05003175 0,10236088 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,05003175 0,10227392 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,05003175 0,1021871 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,05003175 0,10210042 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,05003175 0,1020139 ! ovulation GO:0030728 9 7 0,000 0,05003175 0,10192752 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,05003175 0,10184129 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,05003175 0,1017552 ! microtubule nucleation GO:0007020 20 7 0,000 0,05003175 0,10166926 ! proline biosynthetic process GO:0006561 10 7 0,000 0,05003175 0,10158346 ! thyroid hormone generation GO:0006590 13 7 0,000 0,05003175 0,10149781 ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,05003175 0,1014123 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,05003175 0,10132694 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05003175 0,10124172 ! galactose metabolic process GO:0006012 13 7 0,000 0,05003175 0,10115664 ! vesicle fusion GO:0006906 17 7 0,000 0,05003175 0,1010717 ! response to dietary excess GO:0002021 8 7 0,000 0,05003175 0,10098691 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,05003175 0,10090226 ! intracellular pH reduction GO:0051452 11 7 0,000 0,05003175 0,10081776 GO:0045851|pH reduction, ! melanosome organization GO:0032438 9 7 0,000 0,05003175 0,10073339 ! purine salvage GO:0043101 10 7 0,000 0,05003175 0,10064916 ! nucleoside transport GO:0015858 8 7 0,000 0,05003175 0,10056508 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,05003175 0,10048113 ! parturition GO:0007567 14 7 0,000 0,05003175 0,10039733 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,05003175 0,10031367 ! rRNA modification GO:0000154 14 7 0,000 0,05003175 0,10023014 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,05003175 0,10014676 ! spindle checkpoint GO:0031577 15 7 0,000 0,05003175 0,10006351 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,05003175 0,0999804 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,05003175 0,09989743 ! macrophage differentiation GO:0030225 11 7 0,000 0,05003175 0,09981459 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05003175 0,0997319 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,05003175 0,09964934 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,05003175 0,09956691 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,05003175 0,09948463 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,05003175 0,09940248 ! eating behavior GO:0042755 7 7 0,000 0,05003175 0,09932046 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,05003175 0,09923858 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,05003175 0,09915684 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,05003175 0,09907523 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,05003175 0,09899375 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,05003175 0,09891241 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,05003175 0,0988312 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,05003175 0,09875012 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,05003175 0,09866918 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,05003175 0,09858837 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,05003175 0,09850769 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,05003175 0,09842715 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,05003175 0,09834673 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,05003175 0,09826645 ! regulation of meiosis GO:0040020 12 7 0,000 0,05003175 0,0981863 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,05003175 0,09810628 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,05003175 0,09802638 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,05003175 0,09794662 ! oxygen homeostasis GO:0032364 12 7 0,000 0,05003175 0,09786699 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,05003175 0,09778749 ! anaphase GO:0051322 17 7 0,000 0,05003175 0,09770812 GO:0000090|mitotic anaphase, ! axonal fasciculation GO:0007413 18 7 0,000 0,05003175 0,09762887 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,05003175 0,09754976 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,05003175 0,09747077 ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,05003175 0,09739191 ! thiamin metabolic process GO:0006772 7 7 0,000 0,05003175 0,09731318 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05003175 0,09723457 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,05003175 0,09715609 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,05003175 0,09707774 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,05003175 0,09699952 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05003175 0,09692142 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05003175 0,09684344 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05003175 0,09676559 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,05003175 0,09668787 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,05003175 0,09661027 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,05003175 0,0965328 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,05003175 0,09645545 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,05003175 0,09637822 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05003175 0,09630112 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,05003175 0,09622414 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,05003175 0,09614728 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,05003175 0,09607055 ! adult feeding behavior GO:0008343 9 7 0,000 0,05003175 0,09599394 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,05003175 0,09591745 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,05003175 0,09584108 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,05003175 0,09576484 ! muscle adaptation GO:0043500 14 7 0,000 0,05003175 0,09568871 ! embryonic heart tube development GO:0035050 10 7 0,000 0,05003175 0,09561271 ! retina homeostasis GO:0001895 12 7 0,000 0,05003175 0,09553683 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,05003175 0,09546106 ! protein prenylation GO:0018342 18 7 0,000 0,05003175 0,09538542 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,05003175 0,0953099 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,05003175 0,09523449 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05003175 0,09515921 ! neuromuscular process GO:0050905 99 50 1,000 0,05175501 0,09835906 ! regulation of ossification GO:0030278 117 50 1,000 0,05175501 0,09828143 ! positive regulation of binding GO:0051099 78 51 1,000 0,05361494 0,10173309 ! viral infectious cycle GO:0019058 99 51 1,000 0,05361494 0,10165292 ! response to estrogen stimulus GO:0043627 93 51 1,000 0,05361494 0,10157288 ! excretion GO:0007588 83 51 1,000 0,05361494 0,10149296 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 1,000 0,05361494 0,10141317 ! chromatin remodeling GO:0006338 109 51 1,000 0,05361494 0,10133351 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 1,000 0,05361494 0,10125397 ! vesicle organization GO:0016050 107 51 1,000 0,05361494 0,10117455 ! synapse organization GO:0050808 85 52 1,000 0,05549832 0,10464651 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,05697274 0,10734253 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,05697274 0,10725853 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,05697274 0,10717467 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05697274 0,10709094 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05697274 0,10700734 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,05697274 0,10692387 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,05697274 0,10684053 ! meiotic prophase I GO:0007128 13 8 0,000 0,05697274 0,10675733 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05697274 0,10667425 ! oligopeptide transport GO:0006857 15 8 0,000 0,05697274 0,1065913 ! UTP metabolic process GO:0046051 8 8 0,000 0,05697274 0,10650847 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,05697274 0,10642578 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,05697274 0,10634322 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05697274 0,10626078 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05697274 0,10617847 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,05697274 0,10609629 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,05697274 0,10601424 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,05697274 0,10593231 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05697274 0,10585051 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05697274 0,10576883 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,05697274 0,10568728 ! reflex GO:0060004 16 8 0,000 0,05697274 0,10560586 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,05697274 0,10552456 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,05697274 0,10544339 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05697274 0,10536234 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,05697274 0,10528142 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,05697274 0,10520062 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,05697274 0,10511994 ! histidine metabolic process GO:0006547 16 8 0,000 0,05697274 0,10503939 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05697274 0,10495896 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,05697274 0,10487866 ! glycine catabolic process GO:0006546 13 8 0,000 0,05697274 0,10479848 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,05697274 0,10471842 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,05697274 0,10463848 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,05697274 0,10455866 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,05697274 0,10447897 ! macrophage activation GO:0042116 12 8 0,000 0,05697274 0,1043994 ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,05697274 0,10431994 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,05697274 0,10424061 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05697274 0,1041614 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,05697274 0,10408231 ! osteoblast development GO:0002076 16 8 0,000 0,05697274 0,10400334 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,05697274 0,10392449 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,05697274 0,10384576 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,05697274 0,10376715 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,05697274 0,10368866 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05697274 0,10361028 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,05697274 0,10353203 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05697274 0,10345389 ! intermediate filament organization GO:0045109 12 8 0,000 0,05697274 0,10337587 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,05697274 0,10329797 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,05697274 0,10322019 ! cellular extravasation GO:0045123 12 8 0,000 0,05697274 0,10314252 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,05697274 0,10306497 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,05697274 0,10298753 ! response to antibiotic GO:0046677 11 8 0,000 0,05697274 0,10291021 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,05697274 0,10283301 ! response to tropane GO:0014073 15 8 0,000 0,05697274 0,10275593 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,05697274 0,10267896 ! melanosome transport GO:0032402 13 8 0,000 0,05697274 0,1026021 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,05697274 0,10252536 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05697274 0,10244873 ! mast cell activation GO:0045576 14 8 0,000 0,05697274 0,10237222 ! multicellular organismal aging GO:0010259 18 8 0,000 0,05697274 0,10229583 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,05697274 0,10221954 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,05697274 0,10214337 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,05697274 0,10206732 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05697274 0,10199137 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05697274 0,10191554 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,05697274 0,10183983 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05697274 0,10176422 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05697274 0,10168873 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,05697274 0,10161335 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,05697274 0,10153808 ! intracellular lipid transport GO:0032365 13 8 0,000 0,05697274 0,10146292 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05697274 0,10138787 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05697274 0,10131294 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,05697274 0,10123811 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,05697274 0,1011634 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05697274 0,10108879 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,05697274 0,1010143 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,05697274 0,10093992 ! hormone catabolic process GO:0042447 17 8 0,000 0,05697274 0,10086564 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05697274 0,10079147 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,05697274 0,10071742 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,05697274 0,10064347 ! ATP catabolic process GO:0006200 11 8 0,000 0,05697274 0,10056963 ! blastocyst growth GO:0001832 19 8 0,000 0,05697274 0,1004959 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05697274 0,10042228 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05697274 0,10034876 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,05697274 0,10027535 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05697274 0,10020205 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05697274 0,10012886 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,05697274 0,10005577 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,05697274 0,09998279 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,05697274 0,09990992 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,05697274 0,09983715 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,05697274 0,09976449 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,05697274 0,09969193 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05697274 0,09961948 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,05697274 0,09954714 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05697274 0,0994749 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05697274 0,09940276 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,05697274 0,09933073 ! NAD biosynthetic process GO:0009435 13 8 0,000 0,05697274 0,0992588 ! lipoprotein biosynthetic process GO:0042158 101 53 1,000 0,05740469 0,099939 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 1,000 0,05740469 0,09986673 ! cell maturation GO:0048469 100 53 1,000 0,05740469 0,09979458 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 1,000 0,05933364 0,10307346 ! regulation of protein catabolic process GO:0042176 116 55 1,000 0,06128474 0,10638606 ! heart morphogenesis GO:0003007 97 55 1,000 0,06128474 0,10630935 ! RNA elongation GO:0006354 79 55 1,000 0,06128474 0,10623276 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,06325755 0,10957355 ! axon extension GO:0048675 15 9 0,000 0,06386324 0,11054312 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,06386324 0,11046365 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,06386324 0,1103843 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,06386324 0,11030506 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06386324 0,11022593 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,06386324 0,11014691 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,06386324 0,11006801 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,06386324 0,10998922 ! phosphate transport GO:0006817 19 9 0,000 0,06386324 0,10991055 ! reproductive behavior GO:0019098 19 9 0,000 0,06386324 0,10983198 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06386324 0,10975353 ! CTP metabolic process GO:0046036 9 9 0,000 0,06386324 0,10967519 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,06386324 0,10959696 ! GTP metabolic process GO:0046039 9 9 0,000 0,06386324 0,10951885 ! RNA methylation GO:0001510 15 9 0,000 0,06386324 0,10944084 ! elastic fiber assembly GO:0048251 15 9 0,000 0,06386324 0,10936295 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,06386324 0,10928517 ! regulation of histone modification GO:0031056 12 9 0,000 0,06386324 0,10920749 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,06386324 0,10912993 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,06386324 0,10905248 ! chemosensory behavior GO:0007635 20 9 0,000 0,06386324 0,10897514 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,06386324 0,1088979 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06386324 0,10882078 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,06386324 0,10874377 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,06386324 0,10866686 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06386324 0,10859007 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06386324 0,10851338 ! protein targeting to ER GO:0045047 22 9 0,000 0,06386324 0,1084368 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,06386324 0,10836033 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,06386324 0,10828396 ! endosome organization GO:0007032 17 9 0,000 0,06386324 0,10820771 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06386324 0,10813156 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06386324 0,10805552 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06386324 0,10797958 ! mannose metabolic process GO:0006013 13 9 0,000 0,06386324 0,10790375 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,06386324 0,10782803 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,06386324 0,10775241 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,06386324 0,10767691 ! receptor clustering GO:0043113 18 9 0,000 0,06386324 0,1076015 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,06386324 0,1075262 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06386324 0,10745101 ! ruffle organization GO:0031529 15 9 0,000 0,06386324 0,10737592 ! retinol metabolic process GO:0042572 18 9 0,000 0,06386324 0,10730094 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,06386324 0,10722606 ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,06386324 0,10715129 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,06386324 0,10707662 GO:0030204|chondroitin sulfate metabolic process, ! oligodendrocyte development GO:0014003 10 9 0,000 0,06386324 0,10700205 ! segment specification GO:0007379 13 9 0,000 0,06386324 0,10692759 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06386324 0,10685323 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,06386324 0,10677897 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06386324 0,10670482 ! response to amine stimulus GO:0014075 13 9 0,000 0,06386324 0,10663077 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06386324 0,10655683 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,06386324 0,10648298 ! erythrocyte development GO:0048821 15 9 0,000 0,06386324 0,10640924 ! gas homeostasis GO:0033483 16 9 0,000 0,06386324 0,1063356 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06386324 0,10626206 ! postreplication repair GO:0006301 22 9 0,000 0,06386324 0,10618863 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,06386324 0,10611529 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,06386324 0,10604206 ! icosanoid secretion GO:0032309 15 9 0,000 0,06386324 0,10596893 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06386324 0,1058959 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,06386324 0,10582296 ! regulation of cell division GO:0051302 15 9 0,000 0,06386324 0,10575013 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,06386324 0,1056774 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,06386324 0,10560477 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06386324 0,10553224 ! sterol catabolic process GO:0016127 11 9 0,000 0,06386324 0,10545981 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06386324 0,10538748 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,06386324 0,10531525 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,06386324 0,10524311 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,06386324 0,10517108 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,06386324 0,10509914 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,06386324 0,1050273 ! musculoskeletal movement GO:0050881 14 9 0,000 0,06386324 0,10495556 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,06386324 0,10488392 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,06386324 0,10481238 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06386324 0,10474093 ! purine base metabolic process GO:0006144 21 9 0,000 0,06386324 0,10466958 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,06386324 0,10459833 ! pigment granule transport GO:0051904 17 9 0,000 0,06386324 0,10452717 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,06386324 0,10445611 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,06386324 0,10438515 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06386324 0,10431429 ! mitochondrion localization GO:0051646 15 9 0,000 0,06386324 0,10424352 ! muscle fiber development GO:0048747 112 57 1,000 0,06525167 0,10643763 ! lipid modification GO:0030258 97 57 1,000 0,06525167 0,10636552 ! regulation of intracellular transport GO:0032386 101 57 1,000 0,06525167 0,1062935 ! adult behavior GO:0030534 99 58 1,000 0,06726667 0,10950176 ! positive regulation of secretion GO:0051047 95 59 1,000 0,06930216 0,112739 ! cytokine-mediated signaling pathway GO:0019221 97 59 1,000 0,06930216 0,11266283 ! integrin-mediated signaling pathway GO:0007229 135 59 1,000 0,06930216 0,11258676 ! establishment of organelle localization GO:0051656 109 59 1,000 0,06930216 0,11251079 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,07070361 0,11470863 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,07070361 0,11463133 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,07070361 0,11455414 ! synapsis GO:0007129 13 10 0,000 0,07070361 0,11447705 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,07070361 0,11440006 ! N-glycan processing GO:0006491 20 10 0,000 0,07070361 0,11432318 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,07070361 0,1142464 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,07070361 0,11416973 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,07070361 0,11409315 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,07070361 0,11401668 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,07070361 0,11394032 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,07070361 0,11386405 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,07070361 0,11378789 ! androgen metabolic process GO:0008209 17 10 0,000 0,07070361 0,11371183 ! phospholipid efflux GO:0033700 16 10 0,000 0,07070361 0,11363587 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,07070361 0,11356001 ! lung alveolus development GO:0048286 26 10 0,000 0,07070361 0,11348425 ! pathogenesis GO:0009405 13 10 0,000 0,07070361 0,11340859 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07070361 0,11333304 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,07070361 0,11325758 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,07070361 0,11318223 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,07070361 0,11310698 ! endoderm development GO:0007492 16 10 0,000 0,07070361 0,11303182 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,07070361 0,11295677 ! arginine catabolic process GO:0006527 13 10 0,000 0,07070361 0,11288181 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,07070361 0,11280696 ! proline metabolic process GO:0006560 13 10 0,000 0,07070361 0,1127322 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,07070361 0,11265754 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,07070361 0,11258299 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,07070361 0,11250853 ! V(D)J recombination GO:0033151 28 10 0,000 0,07070361 0,11243417 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07070361 0,1123599 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,07070361 0,11228574 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,07070361 0,11221167 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,07070361 0,1121377 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,07070361 0,11206383 ! multicellular organism growth GO:0035264 18 10 0,000 0,07070361 0,11199005 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,07070361 0,11191638 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,07070361 0,1118428 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,07070361 0,11176931 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,07070361 0,11169592 ! macroautophagy GO:0016236 17 10 0,000 0,07070361 0,11162263 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,07070361 0,11154944 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,07070361 0,11147634 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,07070361 0,11140333 ! copper ion homeostasis GO:0055070 13 10 0,000 0,07070361 0,11133043 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,07070361 0,11125761 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,07070361 0,1111849 ! response to dsRNA GO:0043331 20 10 0,000 0,07070361 0,11111227 ! DNA ligation GO:0006266 19 10 0,000 0,07070361 0,11103975 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,07070361 0,11096731 ! melanosome localization GO:0032400 16 10 0,000 0,07070361 0,11089498 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,07070361 0,11082273 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,07070361 0,11075058 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,07070361 0,11067852 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,07070361 0,11060656 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,07070361 0,11053469 ! mRNA cleavage GO:0006379 17 10 0,000 0,07070361 0,11046292 ! protein sumoylation GO:0016925 15 10 0,000 0,07070361 0,11039123 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,07070361 0,11031964 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,07070361 0,11024815 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,07070361 0,11017674 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,07070361 0,11010543 ! salivary gland development GO:0007431 27 10 0,000 0,07070361 0,11003421 ! prophase GO:0051324 15 10 0,000 0,07070361 0,10996308 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07070361 0,10989205 ! apical protein localization GO:0045176 15 10 0,000 0,07070361 0,10982111 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,07070361 0,10975025 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,07070361 0,10967949 ! positive regulation of leukocyte migration GO:0002687 25 10 0,000 0,07070361 0,10960882 ! midbrain development GO:0030901 13 10 0,000 0,07070361 0,10953824 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,07070361 0,10946776 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,07070361 0,10939736 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,07070361 0,10932705 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,07070361 0,10925684 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,07070361 0,10918671 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,07070361 0,10911667 ! detection of calcium ion GO:0005513 23 10 0,000 0,07070361 0,10904673 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,07070361 0,10897687 ! blastocyst formation GO:0001825 17 10 0,000 0,07070361 0,1089071 ! cerebellar cortex development GO:0021695 15 10 0,000 0,07070361 0,10883742 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,07070361 0,10876783 ! activation of innate immune response GO:0002218 12 10 0,000 0,07070361 0,10869833 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,07070361 0,10862892 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,07070361 0,1085596 ! establishment of cell polarity GO:0030010 16 10 0,000 0,07070361 0,10849036 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,07070361 0,10842122 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,07070361 0,10835216 ! nucleoside metabolic process GO:0009116 81 60 1,000 0,07135772 0,10928496 ! camera-type eye development GO:0043010 116 60 1,000 0,07135772 0,10921544 ! glycerophospholipid biosynthetic process GO:0046474 105 61 1,000 0,07343296 0,11232022 ! gonad development GO:0008406 98 62 1,000 0,07552749 0,11545053 ! respiratory burst GO:0045730 17 11 0,000 0,07749423 0,11838167 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,07749423 0,11830655 ! neuron fate specification GO:0048665 17 11 0,000 0,07749423 0,11823153 ! telencephalon cell migration GO:0022029 20 11 0,000 0,07749423 0,11815661 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,07749423 0,11808178 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,07749423 0,11800704 ! thyroid gland development GO:0030878 26 11 0,000 0,07749423 0,1179324 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,07749423 0,11785785 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,07749423 0,1177834 ! response to pain GO:0048265 24 11 0,000 0,07749423 0,11770904 ! T cell proliferation GO:0042098 26 11 0,000 0,07749423 0,11763478 ! blood vessel remodeling GO:0001974 29 11 0,000 0,07749423 0,11756061 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 0,000 0,07749423 0,11748653 ! bone resorption GO:0045453 16 11 0,000 0,07749423 0,11741255 ! ventral spinal cord development GO:0021517 21 11 0,000 0,07749423 0,11733866 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07749423 0,11726486 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07749423 0,11719115 ! melanocyte differentiation GO:0030318 21 11 0,000 0,07749423 0,11711754 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,07749423 0,11704402 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,07749423 0,11697059 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,07749423 0,11689726 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,07749423 0,11682401 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,07749423 0,11675086 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,07749423 0,1166778 ! adult heart development GO:0007512 14 11 0,000 0,07749423 0,11660483 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07749423 0,11653195 ! temperature homeostasis GO:0001659 17 11 0,000 0,07749423 0,11645917 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,07749423 0,11638647 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,07749423 0,11631386 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,07749423 0,11624135 ! regulation of organ growth GO:0046620 13 11 0,000 0,07749423 0,11616892 ! pigment granule localization GO:0051875 20 11 0,000 0,07749423 0,11609659 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,07749423 0,11602435 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,07749423 0,11595219 ! snRNA metabolic process GO:0016073 24 11 0,000 0,07749423 0,11588013 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07749423 0,11580815 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,07749423 0,11573627 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,07749423 0,11566447 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,07749423 0,11559276 ! zymogen activation GO:0031638 15 11 0,000 0,07749423 0,11552114 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,07749423 0,11544961 ! nucleosome positioning GO:0016584 15 11 0,000 0,07749423 0,11537817 ! regulation of isotype switching GO:0045191 22 11 0,000 0,07749423 0,11530682 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,07749423 0,11523555 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,07749423 0,11516438 ! regulation of leukocyte migration GO:0002685 26 11 0,000 0,07749423 0,11509329 ! acid secretion GO:0046717 18 11 0,000 0,07749423 0,11502229 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07749423 0,11495137 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,07749423 0,11488055 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,07749423 0,11480981 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,07749423 0,11473915 ! cholesterol efflux GO:0033344 19 11 0,000 0,07749423 0,11466859 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07749423 0,11459811 ! germ cell migration GO:0008354 25 11 0,000 0,07749423 0,11452772 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,07749423 0,11445741 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,07749423 0,11438719 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,07749423 0,11431706 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,07749423 0,11424701 ! defense response to fungus GO:0050832 13 11 0,000 0,07749423 0,11417705 ! lysogeny GO:0030069 21 11 0,000 0,07749423 0,11410718 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07749423 0,11403739 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,07749423 0,11396768 ! sequestering of metal ion GO:0051238 14 11 0,000 0,07749423 0,11389806 ! lamellipodium assembly GO:0030032 20 11 0,000 0,07749423 0,11382853 ! nucleus localization GO:0051647 19 11 0,000 0,07749423 0,11375908 ! regulation of synapse organization GO:0050807 17 11 0,000 0,07749423 0,11368971 ! nucleoside monophosphate metabolic process GO:0009123 107 63 1,000 0,07764091 0,11383549 ! regulation of lipid metabolic process GO:0019216 115 63 1,000 0,07764091 0,11376616 ! detection of external stimulus GO:0009581 91 63 1,000 0,07764091 0,11369691 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 1,000 0,07977284 0,11674785 ! lymphocyte mediated immunity GO:0002449 114 64 1,000 0,07977284 0,11667688 ! multicellular organism reproduction GO:0032504 111 64 1,000 0,07977284 0,11660599 GO:0048609|reproductive process in a multicellular organism, ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,0819229 0,11967608 GO:0035113|embryonic appendage morphogenesis, ! myeloid cell differentiation GO:0030099 111 65 1,000 0,0819229 0,11960346 ! secondary metabolic process GO:0019748 116 66 1,000 0,08409072 0,12269392 ! developmental maturation GO:0021700 116 66 1,000 0,08409072 0,12261956 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,08423546 0,12275621 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,08423546 0,12268191 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,08423546 0,12260769 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,08423546 0,12253356 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,08423546 0,12245952 ! cartilage condensation GO:0001502 20 12 0,000 0,08423546 0,12238557 ! mating GO:0007618 17 12 0,000 0,08423546 0,12231171 ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,08423546 0,12223794 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,08423546 0,12216426 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,08423546 0,12209067 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08423546 0,12201716 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,08423546 0,12194375 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,08423546 0,12187042 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,08423546 0,12179718 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,08423546 0,12172403 ! drug transport GO:0015893 16 12 0,000 0,08423546 0,12165097 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,08423546 0,12157799 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,08423546 0,1215051 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,08423546 0,1214323 ! polyamine metabolic process GO:0006595 17 12 0,000 0,08423546 0,12135959 ! mitotic spindle organization GO:0007052 21 12 0,000 0,08423546 0,12128696 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,08423546 0,12121442 ! forebrain cell migration GO:0021885 21 12 0,000 0,08423546 0,12114197 ! asymmetric protein localization GO:0008105 20 12 0,000 0,08423546 0,1210696 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,08423546 0,12099732 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,08423546 0,12092512 ! entry into host cell GO:0030260 32 12 0,000 0,08423546 0,12085302 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,08423546 0,12078099 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08423546 0,12070906 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,08423546 0,12063721 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,08423546 0,12056544 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,08423546 0,12049376 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08423546 0,12042217 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,08423546 0,12035066 ! protein homotetramerization GO:0051289 21 12 0,000 0,08423546 0,12027923 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,08423546 0,12020789 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,08423546 0,12013664 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,08423546 0,12006547 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,08423546 0,11999438 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08423546 0,11992338 ! fucose catabolic process GO:0019317 22 12 0,000 0,08423546 0,11985246 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 23 12 0,000 0,08423546 0,11978162 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,08423546 0,11971087 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,08423546 0,11964021 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,08423546 0,11956962 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,08423546 0,11949912 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,08423546 0,1194287 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,08423546 0,11935837 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,08423546 0,11928812 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,08423546 0,11921795 ! response to cold GO:0009409 17 12 0,000 0,08423546 0,11914786 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,08423546 0,11907785 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,08423546 0,11900793 ! cellular hormone metabolic process GO:0034754 113 67 1,000 0,08627592 0,12181917 ! chromosome segregation GO:0007059 113 67 1,000 0,08627592 0,12174772 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,08627592 0,12167636 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,08627592 0,12160508 ! adaptive immune response GO:0002250 119 67 1,000 0,08627592 0,12153388 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,08847814 0,12456313 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 1,000 0,08847814 0,12449029 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 1,000 0,09069701 0,12753769 ! glycerolipid biosynthetic process GO:0045017 118 69 1,000 0,09069701 0,1274632 ! cGMP metabolic process GO:0046068 18 13 0,000 0,09092764 0,12771273 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,09092764 0,12763822 ! regulation of chemokine production GO:0032642 18 13 0,000 0,09092764 0,12756379 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,09092764 0,12748945 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,09092764 0,1274152 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,09092764 0,12734104 ! lipid localization GO:0010876 28 13 0,000 0,09092764 0,12726696 GO:0019915|lipid storage, ! organelle fusion GO:0048284 32 13 0,000 0,09092764 0,12719297 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,09092764 0,12711906 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,09092764 0,12704524 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,09092764 0,1269715 ! endocrine pancreas development GO:0031018 22 13 0,000 0,09092764 0,12689786 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,09092764 0,12682429 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,09092764 0,12675081 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,09092764 0,12667742 ! methionine metabolic process GO:0006555 27 13 0,000 0,09092764 0,12660411 ! plasma membrane organization GO:0007009 24 13 0,000 0,09092764 0,12653089 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,09092764 0,12645775 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,09092764 0,12638469 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,09092764 0,12631172 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,09092764 0,12623884 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,09092764 0,12616603 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,09092764 0,12609332 ! exocrine system development GO:0035272 32 13 0,000 0,09092764 0,12602068 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,09092764 0,12594813 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,09092764 0,12587566 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,09092764 0,12580328 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,09092764 0,12573098 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,09092764 0,12565876 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,09092764 0,12558663 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,09092764 0,12551457 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,09092764 0,1254426 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,09092764 0,12537072 ! ribosome assembly GO:0042255 17 13 0,000 0,09092764 0,12529891 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,09092764 0,12522719 ! chromatin silencing GO:0006342 26 13 0,000 0,09092764 0,12515555 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,09092764 0,12508399 ! regulation of epidermis development GO:0045682 19 13 0,000 0,09092764 0,12501252 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09092764 0,12494112 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,09092764 0,12486981 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,09092764 0,12479858 ! regulation of mRNA stability GO:0043488 31 13 0,000 0,09092764 0,12472742 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,09092764 0,12465635 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,09092764 0,12458537 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,09092764 0,12451446 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,09092764 0,12444363 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,09092764 0,12437288 ! embryonic placenta development GO:0001892 23 13 0,000 0,09092764 0,12430222 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,09092764 0,12423163 ! insulin secretion GO:0030073 23 13 0,000 0,09092764 0,12416113 ! actin filament polymerization GO:0030041 24 13 0,000 0,09092764 0,1240907 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,09092764 0,12402035 ! acrosome reaction GO:0007340 18 13 0,000 0,09092764 0,12395009 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 1,000 0,09744998 0,13276594 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 1,000 0,09744998 0,1326908 ! rRNA transcription GO:0009303 25 14 0,000 0,09757114 0,13278064 ! lactation GO:0007595 26 14 0,000 0,09757114 0,13270558 ! reproductive cellular process GO:0048610 20 14 0,000 0,09757114 0,1326306 ! tRNA modification GO:0006400 20 14 0,000 0,09757114 0,13255571 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,09757114 0,1324809 ! regulation of S phase GO:0033261 23 14 0,000 0,09757114 0,13240618 ! water transport GO:0006833 21 14 0,000 0,09757114 0,13233155 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,09757114 0,13225699 ! non-recombinational repair GO:0000726 25 14 0,000 0,09757114 0,13218252 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,09757114 0,13210814 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,09757114 0,13203384 ! RNA polyadenylation GO:0043631 30 14 0,000 0,09757114 0,13195962 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,09757114 0,13188548 ! regulated secretory pathway GO:0045055 23 14 0,000 0,09757114 0,13181143 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,09757114 0,13173747 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,09757114 0,13166358 ! arginine metabolic process GO:0006525 17 14 0,000 0,09757114 0,13158978 ! organic alcohol transport GO:0015850 29 14 0,000 0,09757114 0,13151606 ! actin cytoskeleton reorganization GO:0031532 33 14 0,000 0,09757114 0,13144242 ! neutral amino acid transport GO:0015804 26 14 0,000 0,09757114 0,13136887 ! L-amino acid transport GO:0015807 30 14 0,000 0,09757114 0,13129539 ! bone mineralization GO:0030282 17 14 0,000 0,09757114 0,131222 ! stem cell development GO:0048864 43 14 0,000 0,09757114 0,13114869 GO:0019827|stem cell maintenance, ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09757114 0,13107547 ! cerebellum development GO:0021549 21 14 0,000 0,09757114 0,13100232 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,09757114 0,13092926 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,09757114 0,13085628 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,09757114 0,13078338 ! cofactor transport GO:0051181 26 14 0,000 0,09757114 0,13071056 ! NADP metabolic process GO:0006739 24 14 0,000 0,09757114 0,13063782 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,09757114 0,13056516 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,09757114 0,13049259 ! intestinal absorption GO:0050892 25 14 0,000 0,09757114 0,13042009 ! oxygen transport GO:0015671 21 14 0,000 0,09757114 0,13034768 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,09757114 0,13027534 ! male genitalia development GO:0030539 24 14 0,000 0,09757114 0,13020309 ! regulation of RNA stability GO:0043487 32 14 0,000 0,09757114 0,13013091 ! regulation of axon extension GO:0030516 37 14 0,000 0,09757114 0,13005882 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,09757114 0,1299868 ! learning or memory GO:0007611 147 73 1,000 0,09973192 0,13279192 ! lipoprotein metabolic process GO:0042157 131 73 1,000 0,09973192 0,13271848 ! axon guidance GO:0007411 139 73 1,000 0,09973192 0,13264511 ! regulation of actin cytoskeleton organization GO:0032956 149 74 1,000 0,10202877 0,13562499 ! leukocyte mediated immunity GO:0002443 128 74 1,000 0,10202877 0,1355501 ! eye development GO:0001654 143 74 1,000 0,10202877 0,13547529 ! organelle localization GO:0051640 136 74 1,000 0,10202877 0,13540057 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10416631 0,13816105 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! superoxide anion generation GO:0042554 20 15 0,000 0,10416631 0,13808492 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,10416631 0,13800889 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,10416631 0,13793293 ! copper ion transport GO:0006825 20 15 0,000 0,10416631 0,13785706 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,10416631 0,13778127 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,10416631 0,13770557 ! sulfate transport GO:0008272 23 15 0,000 0,10416631 0,13762995 ! response to cAMP GO:0051591 22 15 0,000 0,10416631 0,13755441 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,10416631 0,13747896 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,10416631 0,13740358 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,10416631 0,13732829 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,10416631 0,13725309 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,10416631 0,13717796 ! response to hexose stimulus GO:0009746 22 15 0,000 0,10416631 0,13710292 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,10416631 0,13702796 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,10416631 0,13695308 ! pituitary gland development GO:0021983 29 15 0,000 0,10416631 0,13687828 ! vesicle coating GO:0006901 33 15 0,000 0,10416631 0,13680357 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,10416631 0,13672894 ! regulation of exocytosis GO:0017157 22 15 0,000 0,10416631 0,13665438 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,10416631 0,13657991 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,10416631 0,13650552 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,10416631 0,13643121 ! regulation of vasodilation GO:0042312 26 15 0,000 0,10416631 0,13635698 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,10416631 0,13628284 ! histone deacetylation GO:0016575 20 15 0,000 0,10416631 0,13620877 ! mRNA splice site selection GO:0006376 38 15 0,000 0,10416631 0,13613478 ! tissue regeneration GO:0042246 26 15 0,000 0,10416631 0,13606088 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,10416631 0,13598705 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10416631 0,13591331 ! muscle maintenance GO:0046716 26 15 0,000 0,10416631 0,13583964 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,10416631 0,13576606 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,10416631 0,13569255 ! dopamine metabolic process GO:0042417 35 15 0,000 0,10416631 0,13561912 ! heme biosynthetic process GO:0006783 29 15 0,000 0,10416631 0,13554577 ! cell killing GO:0001906 29 15 0,000 0,10416631 0,13547251 ! detection of bacterium GO:0016045 18 15 0,000 0,10416631 0,13539932 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,10416631 0,13532621 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,10416631 0,13525318 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,10416631 0,13518023 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 1,000 0,10434019 0,13533289 ! rhythmic process GO:0048511 128 75 1,000 0,10434019 0,13525997 ! cytosolic calcium ion homeostasis GO:0051480 135 76 1,000 0,10666585 0,13820034 ! development of primary sexual characteristics GO:0045137 124 76 1,000 0,10666585 0,13812596 ! steroid biosynthetic process GO:0006694 131 76 1,000 0,10666585 0,13805166 ! regulation of actin filament-based process GO:0032970 152 77 1,000 0,10900542 0,14100378 ! positive regulation of ligase activity GO:0051351 124 77 1,000 0,10900542 0,14092801 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,1107135 0,14305944 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,1107135 0,14298265 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,1107135 0,14290594 ! bone remodeling GO:0046849 27 16 0,000 0,1107135 0,14282931 ! filopodium assembly GO:0046847 32 16 0,000 0,1107135 0,14275277 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,1107135 0,14267631 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,1107135 0,14259993 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,1107135 0,14252363 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,1107135 0,14244742 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,1107135 0,14237128 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,1107135 0,14229523 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,1107135 0,14221926 ! protein polyubiquitination GO:0000209 34 16 0,000 0,1107135 0,14214337 ! glutamate metabolic process GO:0006536 22 16 0,000 0,1107135 0,14206756 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,1107135 0,14199183 ! lysosomal transport GO:0007041 26 16 0,000 0,1107135 0,14191618 ! fructose metabolic process GO:0006000 25 16 0,000 0,1107135 0,14184061 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,1107135 0,14176512 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,1107135 0,14168972 ! intermediate filament-based process GO:0045103 32 16 0,000 0,1107135 0,14161439 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,1107135 0,14153914 ! negative regulation of immune response GO:0050777 35 16 0,000 0,1107135 0,14146398 ! axon cargo transport GO:0008088 43 16 0,000 0,1107135 0,14138889 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,1107135 0,14131388 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,1107135 0,14123895 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,1107135 0,14116411 ! DNA replication initiation GO:0006270 27 16 0,000 0,1107135 0,14108934 ! neuron recognition GO:0008038 35 16 0,000 0,1107135 0,14101465 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,1107135 0,14094004 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,1107135 0,1408655 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,1107135 0,14079105 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,1107135 0,14071668 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,1107135 0,14064238 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,1107135 0,14056816 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,1107135 0,14049402 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,1107135 0,14041996 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,1107135 0,14034598 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,1107135 0,14027207 ! response to steroid hormone stimulus GO:0048545 137 78 1,000 0,11135856 0,1410151 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,11372497 0,14393597 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,11610432 0,14687013 ! response to metal ion GO:0010038 140 80 1,000 0,11610432 0,14679296 ! cellular lipid catabolic process GO:0044242 134 80 1,000 0,11610432 0,14671586 ! protein import into nucleus GO:0006606 158 80 1,000 0,11610432 0,14663884 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,11721305 0,14796149 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,11721305 0,1478839 ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,11721305 0,14780639 ! endothelial cell migration GO:0043542 28 17 0,000 0,11721305 0,14772896 ! inositol metabolic process GO:0006020 28 17 0,000 0,11721305 0,14765162 ! gene silencing by RNA GO:0031047 36 17 0,000 0,11721305 0,14757435 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,11721305 0,14749717 ! adult walking behavior GO:0007628 33 17 0,000 0,11721305 0,14742007 ! heart looping GO:0001947 30 17 0,000 0,11721305 0,14734305 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,11721305 0,14726611 ! myoblast differentiation GO:0045445 45 17 0,000 0,11721305 0,14718924 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,11721305 0,14711246 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 0,000 0,11721305 0,14703576 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,11721305 0,14695914 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,11721305 0,1468826 ! glycine metabolic process GO:0006544 28 17 0,000 0,11721305 0,14680614 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,11721305 0,14672976 ! NAD metabolic process GO:0019674 29 17 0,000 0,11721305 0,14665345 ! membrane budding GO:0006900 37 17 0,000 0,11721305 0,14657723 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,11721305 0,14650109 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,11721305 0,14642502 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,11721305 0,14634904 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,11721305 0,14627313 ! genitalia development GO:0048806 30 17 0,000 0,11721305 0,1461973 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,11721305 0,14612155 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,11721305 0,14604588 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,11721305 0,14597029 ! steroid catabolic process GO:0006706 31 17 0,000 0,11721305 0,14589477 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,11721305 0,14581933 ! gas transport GO:0015669 25 17 0,000 0,11721305 0,14574398 ! organic cation transport GO:0015695 31 17 0,000 0,11721305 0,14566869 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,11721305 0,14559349 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,11721305 0,14551837 ! microspike assembly GO:0030035 36 17 0,000 0,11721305 0,14544332 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,11721305 0,14536835 ! nuclear import GO:0051170 161 81 1,000 0,1184963 0,14688413 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,12090061 0,14978726 ! regulation of lyase activity GO:0051339 160 83 1,000 0,12331693 0,15270228 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,12366531 0,15305491 ! neuron maturation GO:0042551 42 18 0,000 0,12366531 0,15297622 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,12366531 0,1528976 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,12366531 0,15281907 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,12366531 0,15274063 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,12366531 0,15266226 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,12366531 0,15258397 ! memory GO:0007613 31 18 0,000 0,12366531 0,15250576 ! negative regulation of ion transport GO:0043271 24 18 0,000 0,12366531 0,15242763 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,12366531 0,15234958 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,12366531 0,15227162 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,12366531 0,15219373 ! glutamine metabolic process GO:0006541 29 18 0,000 0,12366531 0,15211592 ! response to fungus GO:0009620 21 18 0,000 0,12366531 0,15203819 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,12366531 0,15196054 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,12366531 0,15188297 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,12366531 0,15180548 ! vitamin transport GO:0051180 27 18 0,000 0,12366531 0,15172807 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,12366531 0,15165073 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,12366531 0,15157348 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,12366531 0,1514963 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,12366531 0,15141921 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,12366531 0,15134219 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,12574496 0,15380904 ! one-carbon metabolic process GO:0006730 154 85 1,000 0,12818442 0,15671326 ! positive regulation of translation GO:0045727 30 19 0,000 0,13007063 0,15893851 ! negative regulation of defense response GO:0031348 25 19 0,000 0,13007063 0,15885783 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,13007063 0,15877724 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,13007063 0,15869672 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,13007063 0,15861629 ! bile acid metabolic process GO:0008206 29 19 0,000 0,13007063 0,15853593 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,13007063 0,15845566 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,13007063 0,15837547 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,13007063 0,15829536 GO:0030968|endoplasmic reticulum unfolded protein response, ! heme metabolic process GO:0042168 36 19 0,000 0,13007063 0,15821533 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,13007063 0,15813539 ! plasma membrane fusion GO:0045026 28 19 0,000 0,13007063 0,15805552 ! peptide cross-linking GO:0018149 37 19 0,000 0,13007063 0,15797573 ! protein export from nucleus GO:0006611 36 19 0,000 0,13007063 0,15789603 ! heart process GO:0003015 30 19 0,000 0,13007063 0,1578164 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,13007063 0,15773686 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,13007063 0,1576574 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,13007063 0,15757801 ! cell-cell junction organization GO:0045216 35 19 0,000 0,13007063 0,15749871 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,13007063 0,15741948 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,13007063 0,15734034 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,13007063 0,15726127 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,13007063 0,15718229 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,13007063 0,15710338 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,13007063 0,15702455 ! cilium assembly GO:0042384 37 19 0,000 0,13007063 0,1569458 ! response to inorganic substance GO:0010035 153 86 1,000 0,13063499 0,15754776 ! protein localization in nucleus GO:0034504 176 87 1,000 0,1330964 0,16043584 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,13642934 0,16437105 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,13642934 0,16428878 ! positive regulation of ossification GO:0045778 47 20 0,000 0,13642934 0,1642066 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,13642934 0,16412449 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,13642934 0,16404247 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 0,000 0,13642934 0,16396053 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,13642934 0,16387868 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,13642934 0,1637969 ! retinoid metabolic process GO:0001523 32 20 0,000 0,13642934 0,16371521 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,13642934 0,16363359 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,13642934 0,16355206 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,13642934 0,16347061 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,13642934 0,16338924 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,13642934 0,16330795 ! stem cell differentiation GO:0048863 53 20 0,000 0,13642934 0,16322675 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,13642934 0,16314562 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,13642934 0,16306457 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,13642934 0,16298361 ! sensory perception of pain GO:0019233 30 20 0,000 0,13642934 0,16290272 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,13642934 0,16282192 ! diencephalon development GO:0021536 34 20 0,000 0,13642934 0,16274119 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,13642934 0,16266055 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,13642934 0,16257998 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,13642934 0,1624995 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,13642934 0,16241909 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,13642934 0,16233877 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,13642934 0,16225852 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,13642934 0,16217835 ! actin filament-based movement GO:0030048 43 20 0,000 0,13642934 0,16209827 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,13642934 0,16201826 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,13642934 0,16193833 ! regulation of cell killing GO:0031341 42 21 0,000 0,14274178 0,1693475 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,14274178 0,16926403 ! glycerol metabolic process GO:0006071 34 21 0,000 0,14274178 0,16918065 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,14274178 0,16909735 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,14274178 0,16901413 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,14274178 0,168931 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,14274178 0,16884795 ! cytolysis GO:0019835 24 21 0,000 0,14274178 0,16876497 ! vasodilation GO:0042311 39 21 0,000 0,14274178 0,16868208 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,14274178 0,16859927 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,14274178 0,16851655 ! DNA modification GO:0006304 34 21 0,000 0,14274178 0,1684339 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,14274178 0,16835133 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,14274178 0,16826885 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,14274178 0,16818645 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,14274178 0,16810412 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,14274178 0,16802188 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,14274178 0,16793972 ! collagen catabolic process GO:0030574 28 21 0,000 0,14274178 0,16785764 ! sperm-egg recognition GO:0035036 21 21 0,000 0,14274178 0,16777563 ! response to protein stimulus GO:0051789 149 91 1,000 0,14304466 0,16804953 ! vitamin metabolic process GO:0006766 139 92 1,000 0,14555599 0,1709164 ! phospholipid biosynthetic process GO:0008654 167 92 1,000 0,14555599 0,17083303 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 1,000 0,14807648 0,17370649 GO:0010498|proteasomal protein catabolic process, ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,14900829 0,17471439 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,14900829 0,17462929 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,14900829 0,17454427 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,14900829 0,17445934 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,14900829 0,17437448 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,14900829 0,17428971 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,14900829 0,17420502 ! keratinization GO:0031424 28 22 0,000 0,14900829 0,17412042 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,14900829 0,17403589 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,14900829 0,17395145 ! sensory perception of taste GO:0050909 28 22 0,000 0,14900829 0,17386709 ! vacuolar transport GO:0007034 36 22 0,000 0,14900829 0,17378281 ! lysosome organization GO:0007040 41 22 0,000 0,14900829 0,17369861 ! central nervous system neuron development GO:0021954 46 22 0,000 0,14900829 0,1736145 ! fucose metabolic process GO:0006004 39 22 0,000 0,14900829 0,17353046 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,14900829 0,17344651 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,14900829 0,17336264 GO:0060415|muscle tissue morphogenesis, ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,14900829 0,17327885 ! positive regulation of intracellular transport GO:0032388 37 22 0,000 0,14900829 0,17319514 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,14900829 0,17311151 ! sarcomere organization GO:0045214 30 22 0,000 0,14900829 0,17302796 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,14900829 0,1729445 ! protein stabilization GO:0050821 39 22 0,000 0,14900829 0,17286111 ! gluconeogenesis GO:0006094 33 23 0,000 0,15522919 0,17999105 ! viral genome replication GO:0019079 41 23 0,000 0,15522919 0,17990435 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,15522919 0,17981774 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,15522919 0,1797312 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,15522919 0,17964475 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,15522919 0,17955838 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,15522919 0,1794721 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,15522919 0,1793859 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,15522919 0,17929978 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,15522919 0,17921374 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,15522919 0,17912779 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,15522919 0,17904192 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,15522919 0,17895613 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,15522919 0,17887042 GO:0051693|actin filament capping, ! leukotriene metabolic process GO:0006691 42 23 0,000 0,15522919 0,1787848 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,15522919 0,17869925 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,15522919 0,17861379 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,15522919 0,17852841 ! fatty acid transport GO:0015908 44 23 0,000 0,15522919 0,17844311 ! platelet activation GO:0030168 37 23 0,000 0,15522919 0,1783579 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,15522919 0,17827276 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,15522919 0,17818771 ! cell-cell recognition GO:0009988 25 23 0,000 0,15522919 0,17810274 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,15522919 0,17801785 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,15522919 0,17793303 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,15522919 0,1778483 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,15522919 0,17776365 ! detection of stimulus GO:0051606 151 96 1,000 0,1556903 0,17820688 ! response to virus GO:0009615 160 98 1,000 0,16080721 0,18397629 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 1,000 0,16080721 0,18388885 ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,16140483 0,18448457 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,16140483 0,18439697 ! vesicle docking GO:0048278 47 24 0,000 0,16140483 0,18430945 ! vacuole organization GO:0007033 43 24 0,000 0,16140483 0,18422202 ! digestive system process GO:0022600 39 24 0,000 0,16140483 0,18413467 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,16140483 0,1840474 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,16140483 0,18396022 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,16140483 0,18387311 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,16140483 0,18378609 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,16140483 0,18369916 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,16140483 0,1836123 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,16140483 0,18352553 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,16140483 0,18343884 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,16140483 0,18335223 ! regulation of amine transport GO:0051952 40 24 0,000 0,16140483 0,1832657 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,16753552 0,19013701 ! phototransduction GO:0007602 33 25 0,000 0,16753552 0,19004737 ! sperm motility GO:0030317 31 25 0,000 0,16753552 0,18995781 ! receptor metabolic process GO:0043112 46 25 0,000 0,16753552 0,18986833 ! chromosome condensation GO:0030261 45 25 0,000 0,16753552 0,18977894 ! coenzyme catabolic process GO:0009109 39 25 0,000 0,16753552 0,18968963 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,16753552 0,18960041 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,16753552 0,18951127 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,16753552 0,18942221 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,16753552 0,18933324 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,16753552 0,18924435 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,16753552 0,18915554 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,16753552 0,18906682 ! telomere organization GO:0032200 43 25 0,000 0,16753552 0,18897818 GO:0000723|telomere maintenance, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,1736216 0,19575144 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,1736216 0,19565975 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,1736216 0,19556815 ! initiation of viral infection GO:0019059 57 26 0,000 0,1736216 0,19547663 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,1736216 0,1953852 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,1736216 0,19529386 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,1736216 0,1952026 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,1736216 0,19511143 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,1736216 0,19502034 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,1736216 0,19492933 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,1736216 0,19483842 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,1736216 0,19474758 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,1736216 0,19465683 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,1736216 0,19456617 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,1736216 0,19447559 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,1736216 0,19438509 ! blastocyst development GO:0001824 49 26 0,000 0,1736216 0,19429468 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,1736216 0,19420435 ! neuron fate commitment GO:0048663 48 27 0,000 0,17966338 0,200869 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,17966338 0,2007757 ! iron ion transport GO:0006826 59 27 0,000 0,17966338 0,20068249 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,17966338 0,20058937 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,17966338 0,20049633 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,17966338 0,20040338 ! fat cell differentiation GO:0045444 50 27 0,000 0,17966338 0,20031051 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,17966338 0,20021773 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,17966338 0,20012504 ! autophagy GO:0006914 41 27 0,000 0,17966338 0,20003243 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,17966338 0,19993991 ! glutathione metabolic process GO:0006749 39 27 0,000 0,17966338 0,19984748 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,17966338 0,19975512 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,17966338 0,19966286 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,18566119 0,20623306 ! circadian rhythm GO:0007623 50 28 0,000 0,18566119 0,20613789 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,18566119 0,20604281 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,18566119 0,20594782 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,18566119 0,20585291 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,18566119 0,20575809 ! synaptogenesis GO:0007416 42 28 0,000 0,18566119 0,20566336 ! lipid oxidation GO:0034440 43 28 0,000 0,18566119 0,20556871 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,18566119 0,20547416 ! translational initiation GO:0006413 65 29 0,000 0,19161534 0,21196621 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,19161534 0,2118688 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,19161534 0,21177148 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,19161534 0,21167425 ! catechol metabolic process GO:0009712 54 29 0,000 0,19161534 0,2115771 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,19161534 0,21148005 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,19161534 0,21138309 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,19161534 0,21128621 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,19161534 0,21118942 ! cell fate determination GO:0001709 60 29 0,000 0,19161534 0,21109272 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,19161534 0,21099611 ! detection of light stimulus GO:0009583 38 29 0,000 0,19161534 0,21089959 ! phenol metabolic process GO:0018958 55 30 0,000 0,19752616 0,21730587 ! zinc ion transport GO:0006829 45 30 0,000 0,19752616 0,21720655 ! membrane docking GO:0022406 61 30 0,000 0,19752616 0,21710732 ! regulation of innate immune response GO:0045088 51 30 0,000 0,19752616 0,21700819 ! acute-phase response GO:0006953 49 30 0,000 0,19752616 0,21690914 ! myofibril assembly GO:0030239 47 30 0,000 0,19752616 0,21681019 GO:0055002|striated muscle cell development, ! phospholipid transport GO:0015914 51 30 0,000 0,19752616 0,21671132 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,19752616 0,21661255 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,19752616 0,21651386 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,19752616 0,21641527 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,20339395 0,22274276 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,20339395 0,22264142 ! collagen metabolic process GO:0032963 45 31 0,000 0,20339395 0,22254017 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,20339395 0,22243902 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,20339395 0,22233796 GO:0055092|sterol homeostasis, ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,20339395 0,22223698 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,20339395 0,22213611 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,20339395 0,22203532 ! mesoderm formation GO:0001707 69 31 0,000 0,20339395 0,22193462 ! natural killer cell activation GO:0030101 45 31 0,000 0,20339395 0,22183402 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,20339395 0,2217335 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,20339395 0,22163308 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,20339395 0,22153275 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,20921903 0,2277742 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,20921903 0,22767118 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,20921903 0,22756826 ! cholesterol transport GO:0030301 56 32 0,000 0,20921903 0,22746542 ! spliceosome assembly GO:0000245 67 32 0,000 0,20921903 0,22736268 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,20921903 0,22726004 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,20921903 0,22715748 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,20921903 0,22705502 ! muscle cell development GO:0055001 49 32 0,000 0,20921903 0,22695265 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,20921903 0,22685037 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,20921903 0,22674819 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,20921903 0,2266461 ! BMP signaling pathway GO:0030509 64 32 0,000 0,20921903 0,2265441 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,20921903 0,22644219 ! gene silencing GO:0016458 65 32 0,000 0,20921903 0,22634037 ! protein targeting to membrane GO:0006612 68 33 0,000 0,2150017 0,23249173 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,2150017 0,23238729 ! ceramide metabolic process GO:0006672 64 33 0,000 0,2150017 0,23228294 ! formation of primary germ layer GO:0001704 72 33 0,000 0,2150017 0,23217868 ! sterol transport GO:0015918 57 33 0,000 0,2150017 0,23207452 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,2150017 0,23197045 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,2150017 0,23186647 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,22074228 0,23795069 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,22074228 0,23784413 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,22074228 0,23773766 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,22074228 0,23763129 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,22074228 0,23752502 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,22074228 0,23741884 ! placenta development GO:0001890 53 34 0,000 0,22074228 0,23731275 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,22644107 0,24333061 ! vesicle localization GO:0051648 64 35 0,000 0,22644107 0,24322198 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,23209838 0,24918728 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,23209838 0,24907613 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,23209838 0,24896509 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,23209838 0,24885414 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,23209838 0,24874329 ! aerobic respiration GO:0009060 55 36 0,000 0,23209838 0,24863254 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,23209838 0,24852189 ! RNA export from nucleus GO:0006405 56 37 0,000 0,23771449 0,25442218 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,23771449 0,25430906 ! actomyosin structure organization GO:0031032 62 37 0,000 0,23771449 0,25419603 ! organic anion transport GO:0015711 68 37 0,000 0,23771449 0,2540831 ! tissue remodeling GO:0048771 76 37 0,000 0,23771449 0,25397028 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,23771449 0,25385755 GO:0015986|ATP synthesis coupled proton transport, ! glycogen metabolic process GO:0005977 61 37 0,000 0,23771449 0,25374493 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,24328972 0,25958096 GO:0006956|complement activation, ! regulation of neuron projection development GO:0010975 91 38 0,000 0,24328972 0,2594659 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,24328972 0,25935094 ! lipid homeostasis GO:0055088 67 38 0,000 0,24328972 0,25923608 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,24328972 0,25912132 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,24328972 0,25900666 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,24328972 0,25889211 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,24328972 0,25877766 ! glucan metabolic process GO:0044042 62 38 0,000 0,24328972 0,25866331 GO:0006073|cellular glucan metabolic process, ! mRNA catabolic process GO:0006402 71 39 0,000 0,24882435 0,26443083 ! ion transmembrane transport GO:0034220 66 39 0,000 0,24882435 0,26431408 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,24882435 0,26419744 ! RNA modification GO:0009451 57 39 0,000 0,24882435 0,2640809 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,24882435 0,26396446 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,25431869 0,2696742 ! feeding behavior GO:0007631 59 40 0,000 0,25431869 0,2695554 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,25431869 0,26943671 ! maintenance of protein location GO:0045185 91 40 0,000 0,25431869 0,26931812 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,25977302 0,27497311 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,25977302 0,27485219 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,25977302 0,27473138 ! polyol metabolic process GO:0019751 66 41 0,000 0,25977302 0,27461067 ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,26518763 0,28021144 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,26518763 0,28008843 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,26518763 0,27996553 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,26518763 0,27984274 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,26518763 0,27972005 ! energy reserve metabolic process GO:0006112 74 43 0,000 0,27056282 0,28526474 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,27056282 0,28513979 ! striated muscle contraction GO:0006941 77 43 0,000 0,27056282 0,28501495 ! phagocytosis GO:0006909 90 43 0,000 0,27056282 0,28489022 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,27056282 0,28476559 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,27589886 0,29025477 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,27589886 0,29012791 ! maintenance of location in cell GO:0051651 97 44 0,000 0,27589886 0,29000116 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,28119605 0,29544004 ! glycolysis GO:0006096 65 45 0,000 0,28119605 0,29531108 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,28119605 0,29518224 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,28119605 0,29505351 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,28119605 0,29492489 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,28119605 0,29479638 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,28119605 0,29466798 ! positive regulation of protein transport GO:0051222 72 46 0,000 0,28645466 0,30004785 ! response to calcium ion GO:0051592 81 47 0,000 0,29167497 0,30538293 ! endosome transport GO:0016197 108 47 0,000 0,29167497 0,3052501 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,29167497 0,30511738 ! protein homooligomerization GO:0051260 76 47 0,000 0,29167497 0,30498478 ! Notch signaling pathway GO:0007219 96 48 0,000 0,29685726 0,31026871 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,29685726 0,31013398 ! regulation of ion transport GO:0043269 77 49 0,000 0,30200181 0,31537168 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,30200181 0,31523486 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,30200181 0,31509816 ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,30200181 0,31496157 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,30710888 0,32014904 ! inner ear development GO:0048839 79 50 0,000 0,30710888 0,32001038 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,30710888 0,31987185 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,30710888 0,31973344 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,31217876 0,32487115 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,31217876 0,3247307 ! regulation of cell shape GO:0008360 125 51 0,000 0,31217876 0,32459036 ! membrane fusion GO:0006944 110 52 0,000 0,31721171 0,32968094 ! amino acid activation GO:0043038 92 52 0,000 0,31721171 0,32953859 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 76 53 0,000 0,322208 0,33458457 ! RNA catabolic process GO:0006401 93 53 0,000 0,322208 0,33444023 ! regulation of translational initiation GO:0006446 82 53 0,000 0,322208 0,33429601 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,322208 0,33415192 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,322208 0,33400795 ! cell recognition GO:0008037 85 54 0,000 0,32716789 0,33900343 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,32716789 0,33885749 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,32716789 0,33871168 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,32716789 0,338566 ! chloride transport GO:0006821 90 55 0,000 0,33209166 0,34351355 ! glucose catabolic process GO:0006007 82 55 0,000 0,33209166 0,34336593 ! cellular polysaccharide metabolic process GO:0044264 86 55 0,000 0,33209166 0,34321844 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,33209166 0,34307107 ! gastrulation GO:0007369 112 55 0,000 0,33209166 0,34292383 ! nuclear export GO:0051168 97 55 0,000 0,33209166 0,34277672 ! regulation of actin filament length GO:0030832 105 56 0,000 0,33697955 0,34767273 ! sensory perception of smell GO:0007608 80 56 0,000 0,33697955 0,3475237 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,33697955 0,34737481 ! proton transport GO:0015992 94 56 0,000 0,33697955 0,34722604 ! maintenance of location GO:0051235 118 57 0,000 0,34183183 0,35207508 ! hydrogen transport GO:0006818 97 58 0,000 0,34664877 0,35688358 ! regulation of endocytosis GO:0030100 91 58 0,000 0,34664877 0,35673094 ! regulation of cellular component size GO:0032535 109 59 0,000 0,3514306 0,36149724 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,3514306 0,36134275 GO:0032313|regulation of Rab GTPase activity, ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,3561776 0,3660672 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,36089001 0,37075208 ! mesoderm development GO:0007498 119 61 0,000 0,36089001 0,37059384 ! tRNA processing GO:0008033 89 61 0,000 0,36089001 0,37043574 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,36089001 0,37027777 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,36556809 0,37491765 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,37021207 0,37951864 ! cell redox homeostasis GO:0045454 102 64 0,000 0,37482222 0,38408103 ! single fertilization GO:0007338 75 64 0,000 0,37482222 0,38391752 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,37939877 0,38843976 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,37939877 0,38827454 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,38394197 0,39275697 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,38394197 0,39259005 ! cell projection assembly GO:0030031 120 66 0,000 0,38394197 0,39242327 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,38845206 0,3968644 ! hexose catabolic process GO:0019320 104 67 0,000 0,38845206 0,39669595 ! activation of immune response GO:0002253 105 67 0,000 0,38845206 0,39652765 ! amino acid transport GO:0006865 125 68 0,000 0,39292929 0,40092785 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,39292929 0,40075789 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,39737388 0,4051193 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,39737388 0,40494772 ! antigen processing and presentation GO:0019882 104 69 0,000 0,39737388 0,40477627 ! amine catabolic process GO:0009310 117 71 0,000 0,40616612 0,41355721 ! regulation of immune effector process GO:0002697 137 71 0,000 0,40616612 0,41338227 ! acute inflammatory response GO:0002526 113 72 0,000 0,41051423 0,41763097 ! fertilization GO:0009566 90 73 0,000 0,41483065 0,42184385 ! transition metal ion transport GO:0000041 126 74 0,000 0,41911561 0,42602119 ! neurotransmitter transport GO:0006836 123 74 0,000 0,41911561 0,42584128 ! exocytosis GO:0006887 133 74 0,000 0,41911561 0,42566153 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,42336933 0,42980026 ! defense response to bacterium GO:0042742 89 76 0,000 0,42759205 0,43390403 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,42759205 0,43372111 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,43178398 0,43778856 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,44007638 0,44600832 ! muscle cell differentiation GO:0042692 159 80 0,000 0,44417729 0,44997497 ! inorganic anion transport GO:0015698 138 80 0,000 0,44417729 0,44978559 ! digestion GO:0007586 112 81 0,000 0,4482483 0,45371704 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,4482483 0,45352624 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,45228963 0,4574228 ! response to unfolded protein GO:0006986 131 85 0,000 0,46423767 0,46930917 ! nucleosome assembly GO:0006334 122 85 0,000 0,46423767 0,46911207 ! amine biosynthetic process GO:0009309 138 86 0,000 0,46816241 0,47287941 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,46816241 0,47268097 ! chromatin assembly GO:0031497 124 86 0,000 0,46816241 0,4724827 ! alcohol catabolic process GO:0046164 130 86 0,000 0,46816241 0,47228459 ! amine transport GO:0015837 155 86 0,000 0,46816241 0,47208665 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,47205852 0,475816 ! cellular respiration GO:0045333 135 88 0,000 0,47592622 0,47951361 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,47592622 0,47931289 ! cellular defense response GO:0006968 114 89 0,000 0,47976572 0,48297754 ! regulation of cell morphogenesis GO:0022604 215 89 0,000 0,47976572 0,48277554 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,48357722 0,48640752 ! sterol metabolic process GO:0016125 152 91 0,000 0,48736091 0,4900085 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,48736091 0,48980382 ! nucleosome organization GO:0034728 138 92 0,000 0,49111701 0,49337266 ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,49484571 0,49691101 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,49854721 0,50041911 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,50222172 0,50389719 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,50586942 0,50734548 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,50586942 0,50713409 ! positive regulation of immune response GO:0050778 156 96 0,000 0,50586942 0,50692287 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,50949051 0,51033895 ! protein ubiquitination GO:0016567 217 97 0,000 0,50949051 0,51012657 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,51308518 0,51351204 GO:0016054|organic acid catabolic process, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,51665363 0,51686845 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,51665363 0,51665363