pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6434-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 9,000 5,795E-12 1,416E-08 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 4,000 7,731E-10 9,443E-07 ! negative regulation of protein kinase activity GO:0006469 144 69 8,000 1,076E-09 8,762E-07 ! negative regulation of kinase activity GO:0033673 145 70 8,000 1,227E-09 7,497E-07 ! negative regulation of transferase activity GO:0051348 155 74 8,000 2,037E-09 9,955E-07 ! apoptotic mitochondrial changes GO:0008637 42 20 5,000 3,35E-09 1,364E-06 ! nerve growth factor processing GO:0032455 9 5 3,000 1,043E-08 3,638E-06 ! positive regulation of MAP kinase activity GO:0043406 174 93 8,000 1,585E-08 4,84E-06 ! induction of apoptosis by intracellular signals GO:0008629 95 45 6,000 2,264E-08 6,144E-06 ! interphase of mitotic cell cycle GO:0051329 224 98 8,000 2,518E-08 6,151E-06 ! release of cytochrome c from mitochondria GO:0001836 31 14 4,000 2,673E-08 5,937E-06 ! response to UV GO:0009411 120 55 6,000 9,553E-08 1,945E-05 ! negative regulation of phosphorylation GO:0042326 52 24 4,000 5,368E-07 1,009E-04 ! cell cycle checkpoint GO:0000075 145 71 6,000 5,708E-07 9,96E-05 ! branching morphogenesis of a tube GO:0048754 102 45 5,000 6,106E-07 9,944E-05 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 4,000 6,673E-07 1,019E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 6,982E-07 1,003E-04 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 4,000 8,216E-07 1,115E-04 GO:0045936|negative regulation of phosphate metabolic process, ! morphogenesis of a branching structure GO:0001763 116 52 5,000 1,467E-06 1,886E-04 ! regulation of neuron apoptosis GO:0043523 117 53 5,000 1,644E-06 2,009E-04 ! tube morphogenesis GO:0035239 194 89 6,000 2,665E-06 3,101E-04 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 2,000 3,086E-06 3,427E-04 ! peptidyl-threonine phosphorylation GO:0018107 20 5 2,000 3,086E-06 3,278E-04 ! negative regulation of MAP kinase activity GO:0043407 78 34 4,000 3,324E-06 3,384E-04 ! peptide hormone processing GO:0016486 27 16 3,000 3,577E-06 3,496E-04 ! DNA damage checkpoint GO:0000077 78 35 4,000 3,857E-06 3,624E-04 ! DNA damage response, signal transduction GO:0042770 136 62 5,000 4,184E-06 3,786E-04 ! neutrophil chemotaxis GO:0030593 29 17 3,000 4,653E-06 4,06E-04 ! negative regulation of blood coagulation GO:0030195 25 17 3,000 4,653E-06 3,92E-04 ! meiosis I GO:0007127 74 38 4,000 5,865E-06 4,776E-04 ! DNA integrity checkpoint GO:0031570 82 38 4,000 5,865E-06 4,622E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 3,000 5,95E-06 4,543E-04 ! negative regulation of gliogenesis GO:0014014 18 6 2,000 6,141E-06 4,546E-04 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 2,000 6,141E-06 4,412E-04 ! negative regulation of neuroblast proliferation GO:0007406 25 6 2,000 6,141E-06 4,286E-04 ! urogenital system development GO:0001655 149 69 5,000 7,841E-06 5,321E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 5,000 7,841E-06 5,177E-04 ! mesenchymal cell development GO:0014031 94 41 4,000 8,612E-06 5,537E-04 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! negative regulation of coagulation GO:0050819 30 20 3,000 9,321E-06 5,839E-04 ! respiratory tube development GO:0030323 171 72 5,000 1,005E-05 6,136E-04 ! prostate gland development GO:0030850 14 7 2,000 1,069E-05 6,371E-04 ! fibrinolysis GO:0042730 11 7 2,000 1,069E-05 6,219E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 1,069E-05 6,075E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 1,069E-05 5,937E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 1,069E-05 5,805E-04 ! peptidyl-threonine modification GO:0018210 26 7 2,000 1,069E-05 5,679E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 3,000 1,145E-05 5,953E-04 ! renal system process GO:0003014 42 22 3,000 1,392E-05 7,086E-04 ! pigmentation GO:0043473 103 46 4,000 1,532E-05 7,639E-04 ! regulation of cell-matrix adhesion GO:0001952 81 23 3,000 1,676E-05 8,191E-04 GO:0010810|regulation of cell-substrate adhesion, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,702E-05 8,154E-04 ! activation of protein kinase activity GO:0032147 170 80 5,000 1,847E-05 8,676E-04 ! positive regulation of cell cycle GO:0045787 96 48 4,000 1,893E-05 8,725E-04 ! meiosis GO:0007126 143 81 5,000 1,983E-05 8,972E-04 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 5,000 1,983E-05 8,809E-04 ! positive regulation of phosphorylation GO:0042327 149 81 5,000 1,983E-05 8,652E-04 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 3,000 2,001E-05 8,576E-04 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 3,000 2,001E-05 8,428E-04 ! meiotic cell cycle GO:0051321 144 82 5,000 2,128E-05 8,81E-04 ! response to oxygen levels GO:0070482 183 83 5,000 2,281E-05 9,285E-04 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 5,000 2,281E-05 9,133E-04 GO:0045937|positive regulation of phosphate metabolic process, ! induction of positive chemotaxis GO:0050930 17 9 2,000 2,54E-05 1,001E-03 ! middle ear morphogenesis GO:0042474 14 9 2,000 2,54E-05 9,851E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 2,54E-05 9,697E-04 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 2,000 2,54E-05 9,548E-04 GO:0007351|tripartite regional subdivision, ! negative regulation of transport GO:0051051 164 85 5,000 2,613E-05 9,671E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 2,785E-05 1,016E-03 ! negative regulation of cell development GO:0010721 83 26 3,000 2,785E-05 1,001E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of blood coagulation GO:0030193 46 26 3,000 2,785E-05 9,862E-04 ! positive regulation of nuclear division GO:0051785 41 26 3,000 2,785E-05 9,721E-04 GO:0045840|positive regulation of mitosis, ! mitochondrion organization GO:0007005 159 87 5,000 2,983E-05 1,026E-03 ! positive regulation of growth GO:0045927 96 53 4,000 3,086E-05 1,047E-03 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 3,252E-05 1,088E-03 ! regulation of angiogenesis GO:0045765 125 54 4,000 3,382E-05 1,116E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 3,611E-05 1,176E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 3,611E-05 1,161E-03 ! regulation of gliogenesis GO:0014013 23 10 2,000 3,611E-05 1,146E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 3,611E-05 1,131E-03 ! blastoderm segmentation GO:0007350 19 10 2,000 3,611E-05 1,117E-03 ! induction of an organ GO:0001759 17 10 2,000 3,611E-05 1,103E-03 ! regulation of cell cycle process GO:0010564 161 90 5,000 3,616E-05 1,09E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 3,000 3,774E-05 1,124E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 3,774E-05 1,111E-03 ! regulation of JUN kinase activity GO:0043506 67 28 3,000 3,774E-05 1,098E-03 ! gland development GO:0048732 220 91 5,000 3,849E-05 1,106E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 3,000 4,355E-05 1,237E-03 ! negative regulation of neuron apoptosis GO:0043524 69 29 3,000 4,355E-05 1,223E-03 ! positive regulation of cell migration GO:0030335 137 58 4,000 4,793E-05 1,33E-03 ! negative regulation of multicellular organismal process GO:0051241 174 95 5,000 4,906E-05 1,347E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 2,000 4,94E-05 1,341E-03 ! UV protection GO:0009650 20 11 2,000 4,94E-05 1,326E-03 ! chondrocyte differentiation GO:0002062 27 11 2,000 4,94E-05 1,312E-03 ! embryonic axis specification GO:0000578 19 11 2,000 4,94E-05 1,298E-03 ! negative regulation of glucose import GO:0046325 18 11 2,000 4,94E-05 1,284E-03 GO:0010829|negative regulation of glucose transport, ! regulation of coagulation GO:0050818 52 30 3,000 4,998E-05 1,285E-03 ! transcription initiation GO:0006352 171 97 5,000 5,516E-05 1,404E-03 ! hormone metabolic process GO:0042445 171 100 5,000 6,542E-05 1,648E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 6,553E-05 1,634E-03 ! regulation of positive chemotaxis GO:0050926 22 12 2,000 6,553E-05 1,617E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 37 12 2,000 6,553E-05 1,601E-03 ! autonomic nervous system development GO:0048483 24 12 2,000 6,553E-05 1,585E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 6,553E-05 1,57E-03 GO:0042130|negative regulation of T cell proliferation, ! developmental induction GO:0031128 22 12 2,000 6,553E-05 1,554E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of mitosis GO:0007088 112 63 4,000 7,151E-05 1,68E-03 GO:0051783|regulation of nuclear division, ! leukocyte chemotaxis GO:0030595 55 33 3,000 7,344E-05 1,709E-03 GO:0060326|cell chemotaxis, ! response to peptide hormone stimulus GO:0043434 129 64 4,000 7,714E-05 1,778E-03 ! positive regulation of cell motion GO:0051272 157 65 4,000 8,311E-05 1,898E-03 ! anterior/posterior axis specification GO:0009948 22 13 2,000 8,477E-05 1,917E-03 ! regulation of striated muscle tissue development GO:0016202 81 35 3,000 9,297E-05 2,084E-03 ! negative regulation of cell growth GO:0030308 142 67 4,000 9,611E-05 2,135E-03 ! activation of MAPK activity GO:0000187 124 67 4,000 9,611E-05 2,115E-03 ! regulation of muscle development GO:0048634 82 36 3,000 1,04E-04 2,269E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 1,073E-04 2,321E-03 ! response to gamma radiation GO:0010332 30 14 2,000 1,073E-04 2,3E-03 ! negative regulation of cell size GO:0045792 144 69 4,000 1,106E-04 2,35E-03 ! lung development GO:0030324 165 69 4,000 1,106E-04 2,33E-03 ! androgen receptor signaling pathway GO:0030521 81 37 3,000 1,16E-04 2,423E-03 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 1,29E-04 2,67E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 1,335E-04 2,741E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 1,335E-04 2,718E-03 ! regulation of MAPKKK cascade GO:0043408 157 72 4,000 1,354E-04 2,735E-03 ! regulation of caspase activity GO:0043281 136 74 4,000 1,542E-04 3,088E-03 ! respiratory system development GO:0060541 175 74 4,000 1,542E-04 3,063E-03 ! positive regulation of cell size GO:0045793 29 16 2,000 1,635E-04 3,221E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,635E-04 3,195E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 2,000 1,635E-04 3,17E-03 ! phosphoinositide-mediated signaling GO:0048015 141 75 4,000 1,643E-04 3,161E-03 ! cell-matrix adhesion GO:0007160 181 76 4,000 1,749E-04 3,339E-03 ! regulation of endopeptidase activity GO:0052548 141 77 4,000 1,861E-04 3,524E-03 ! regulation of T cell differentiation GO:0045580 78 42 3,000 1,915E-04 3,598E-03 ! activation of MAPKK activity GO:0000186 43 17 2,000 1,975E-04 3,684E-03 ! negative regulation of microtubule depolymerization GO:0007026 50 17 2,000 1,975E-04 3,656E-03 GO:0031114|regulation of microtubule depolymerization, ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 1,975E-04 3,628E-03 ! segmentation GO:0035282 78 43 3,000 2,1E-04 3,828E-03 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 2,000 2,358E-04 4,268E-03 GO:0050886|endocrine process, ! patterning of blood vessels GO:0001569 43 18 2,000 2,358E-04 4,236E-03 ! epidermis morphogenesis GO:0048730 43 18 2,000 2,358E-04 4,205E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 2,358E-04 4,175E-03 ! DNA integration GO:0015074 32 18 2,000 2,358E-04 4,145E-03 ! regulation of BMP signaling pathway GO:0030510 33 18 2,000 2,358E-04 4,115E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 2,000 2,358E-04 4,086E-03 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 4,000 2,36E-04 4,061E-03 ! regulation of peptidase activity GO:0052547 150 82 4,000 2,5E-04 4,27E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 2,5E-04 4,241E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 2,508E-04 4,226E-03 ! leukocyte migration GO:0050900 75 46 3,000 2,732E-04 4,572E-03 ! negative regulation of cell migration GO:0030336 122 46 3,000 2,732E-04 4,541E-03 ! regulation of endothelial cell migration GO:0010594 45 19 2,000 2,786E-04 4,6E-03 ! negative regulation of growth GO:0045926 168 85 4,000 2,956E-04 4,846E-03 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 2,956E-04 4,814E-03 ! regulation of JNK cascade GO:0046328 104 47 3,000 2,971E-04 4,806E-03 ! response to insulin stimulus GO:0032868 98 47 3,000 2,971E-04 4,775E-03 ! cellular component disassembly GO:0022411 89 48 3,000 3,224E-04 5,147E-03 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 3,000 3,224E-04 5,114E-03 ! skin development GO:0043588 42 20 2,000 3,262E-04 5,141E-03 ! response to alkaloid GO:0043279 38 20 2,000 3,262E-04 5,108E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 3,262E-04 5,075E-03 ! actin filament bundle formation GO:0051017 47 20 2,000 3,262E-04 5,043E-03 ! regulation of glucose import GO:0046324 30 20 2,000 3,262E-04 5,012E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 3,262E-04 4,98E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 3,492E-04 5,298E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 3,492E-04 5,265E-03 ! activation of caspase activity GO:0006919 95 50 3,000 3,775E-04 5,658E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 3,786E-04 5,64E-03 ! regulation of vasoconstriction GO:0019229 40 21 2,000 3,786E-04 5,606E-03 ! collagen fibril organization GO:0030199 62 21 2,000 3,786E-04 5,572E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 3,786E-04 5,539E-03 ! regulation of cell adhesion GO:0030155 241 92 4,000 4,264E-04 6,2E-03 ! reciprocal meiotic recombination GO:0007131 44 22 2,000 4,362E-04 6,306E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 4,362E-04 6,269E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 4,362E-04 6,232E-03 ! cell aging GO:0007569 48 22 2,000 4,362E-04 6,196E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 4,362E-04 6,16E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! peptidyl-serine modification GO:0018209 50 22 2,000 4,362E-04 6,125E-03 ! gut development GO:0048565 44 22 2,000 4,362E-04 6,09E-03 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 1,000 4,554E-04 6,322E-03 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 1,000 4,554E-04 6,286E-03 GO:0045844|positive regulation of striated muscle development, ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 4,554E-04 6,251E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 4,554E-04 6,216E-03 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 1,000 4,554E-04 6,181E-03 ! smooth muscle tissue development GO:0048745 32 5 1,000 4,554E-04 6,147E-03 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 1,000 4,554E-04 6,113E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 4,554E-04 6,08E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 4,554E-04 6,047E-03 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 1,000 4,554E-04 6,014E-03 ! valine metabolic process GO:0006573 12 5 1,000 4,554E-04 5,982E-03 ! muscle cell migration GO:0014812 8 5 1,000 4,554E-04 5,95E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 4,554E-04 5,918E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 4,554E-04 5,887E-03 ! peptidyl-histidine phosphorylation GO:0018106 10 5 1,000 4,554E-04 5,856E-03 ! G2/M transition checkpoint GO:0031576 8 5 1,000 4,554E-04 5,825E-03 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 4,554E-04 5,795E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 4,554E-04 5,765E-03 ! forebrain morphogenesis GO:0048853 13 5 1,000 4,554E-04 5,735E-03 ! B cell homeostasis GO:0001782 13 5 1,000 4,554E-04 5,706E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 4,554E-04 5,677E-03 ! regulation of sensory perception GO:0051931 8 5 1,000 4,554E-04 5,648E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 4,554E-04 5,619E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 4,554E-04 5,591E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 4,554E-04 5,563E-03 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 4,554E-04 5,536E-03 GO:0048103|somatic stem cell division, ! regulation of membrane potential GO:0042391 179 94 4,000 4,707E-04 5,693E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 4,724E-04 5,685E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 3,000 4,724E-04 5,657E-03 ! regulation of chemotaxis GO:0050920 45 23 2,000 4,991E-04 5,948E-03 ! axis specification GO:0009798 43 23 2,000 4,991E-04 5,919E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 4,991E-04 5,891E-03 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 2,000 4,991E-04 5,862E-03 ! embryonic skeletal system development GO:0048706 101 54 3,000 5,075E-04 5,932E-03 ! regulation of muscle contraction GO:0006937 94 54 3,000 5,075E-04 5,904E-03 ! regulation of DNA metabolic process GO:0051052 188 97 4,000 5,436E-04 6,294E-03 ! negative regulation of cell motion GO:0051271 142 55 3,000 5,444E-04 6,273E-03 ! pallium development GO:0021543 56 24 2,000 5,676E-04 6,51E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 5,676E-04 6,479E-03 ! regulation of DNA replication GO:0006275 105 56 3,000 5,832E-04 6,626E-03 ! positive regulation of caspase activity GO:0043280 108 57 3,000 6,238E-04 7,056E-03 GO:0010952|positive regulation of peptidase activity, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 6,417E-04 7,225E-03 ! regulation of behavior GO:0050795 48 25 2,000 6,417E-04 7,192E-03 ! protein tetramerization GO:0051262 57 25 2,000 6,417E-04 7,159E-03 ! aging GO:0007568 112 58 3,000 6,665E-04 7,401E-03 ! positive regulation of organelle organization GO:0010638 108 58 3,000 6,665E-04 7,368E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 1,000 6,801E-04 7,484E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 6,801E-04 7,451E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 6,801E-04 7,417E-03 ! activation of MAPKKK activity GO:0000185 12 6 1,000 6,801E-04 7,384E-03 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 1,000 6,801E-04 7,352E-03 ! hyperosmotic response GO:0006972 10 6 1,000 6,801E-04 7,319E-03 ! vascular smooth muscle contraction GO:0014829 13 6 1,000 6,801E-04 7,287E-03 ! positive regulation of muscle hypertrophy GO:0014742 10 6 1,000 6,801E-04 7,255E-03 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! establishment of spindle localization GO:0051293 16 6 1,000 6,801E-04 7,224E-03 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 1,000 6,801E-04 7,193E-03 ! astrocyte development GO:0014002 16 6 1,000 6,801E-04 7,162E-03 ! Schwann cell development GO:0014044 15 6 1,000 6,801E-04 7,131E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 6,801E-04 7,1E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 6,801E-04 7,07E-03 GO:0043011|myeloid dendritic cell differentiation, ! progesterone metabolic process GO:0042448 12 6 1,000 6,801E-04 7,04E-03 ! triglyceride catabolic process GO:0019433 10 6 1,000 6,801E-04 7,01E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 6,801E-04 6,981E-03 ! myelination GO:0042552 50 26 2,000 7,218E-04 7,378E-03 ! positive regulation of JUN kinase activity GO:0043507 59 26 2,000 7,218E-04 7,347E-03 ! DNA catabolic process GO:0006308 94 60 3,000 7,58E-04 7,683E-03 ! kidney development GO:0001822 133 60 3,000 7,58E-04 7,652E-03 ! regulation of heart contraction GO:0008016 123 61 3,000 8,069E-04 8,112E-03 ! embryonic pattern specification GO:0009880 49 27 2,000 8,08E-04 8,09E-03 ! mitochondrial membrane organization GO:0007006 60 27 2,000 8,08E-04 8,057E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 8,08E-04 8,024E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 8,08E-04 7,991E-03 ! regulation of homeostatic process GO:0032844 148 62 3,000 8,579E-04 8,451E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 9,004E-04 8,834E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 9,004E-04 8,799E-03 ! regulation of systemic arterial blood pressure GO:0003073 55 28 2,000 9,004E-04 8,764E-03 ! skeletal system morphogenesis GO:0048705 118 63 3,000 9,112E-04 8,834E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 9,479E-04 9,153E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 9,479E-04 9,117E-03 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 1,000 9,479E-04 9,081E-03 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 9,479E-04 9,045E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 9,479E-04 9,01E-03 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 1,000 9,479E-04 8,975E-03 ! positive regulation of heart rate GO:0010460 11 7 1,000 9,479E-04 8,941E-03 ! adrenal gland development GO:0030325 17 7 1,000 9,479E-04 8,906E-03 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 1,000 9,479E-04 8,872E-03 ! regulation of granule cell precursor proliferation GO:0021936 12 7 1,000 9,479E-04 8,838E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! phasic smooth muscle contraction GO:0014821 12 7 1,000 9,479E-04 8,805E-03 ! glycerol ether catabolic process GO:0044269 12 7 1,000 9,479E-04 8,771E-03 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 1,000 9,479E-04 8,738E-03 ! attachment of GPI anchor to protein GO:0016255 16 7 1,000 9,479E-04 8,705E-03 ! male sex determination GO:0030238 15 7 1,000 9,479E-04 8,673E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 9,479E-04 8,64E-03 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 9,479E-04 8,608E-03 ! transcription termination GO:0006353 14 7 1,000 9,479E-04 8,576E-03 ! peptidyl-histidine modification GO:0018202 17 7 1,000 9,479E-04 8,545E-03 ! diuresis GO:0030146 12 7 1,000 9,479E-04 8,513E-03 GO:0030147|natriuresis, ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 9,479E-04 8,482E-03 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 1,000 9,479E-04 8,451E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 9,669E-04 8,589E-03 ! ear development GO:0043583 114 66 3,000 1,085E-03 9,605E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 1,085E-03 9,57E-03 ! determination of left/right symmetry GO:0007368 53 30 2,000 1,105E-03 9,708E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 2,000 1,105E-03 9,674E-03 ! regulation of B cell activation GO:0050864 55 30 2,000 1,105E-03 9,639E-03 ! regulation of cellular response to stress GO:0080135 142 68 3,000 1,213E-03 0,01054789 ! determination of bilateral symmetry GO:0009855 55 31 2,000 1,217E-03 0,01054304 GO:0009799|determination of symmetry, ! cell junction assembly GO:0034329 85 31 2,000 1,217E-03 0,01050579 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 1,217E-03 0,0104688 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 1,217E-03 0,01043206 ! ensheathment of neurons GO:0007272 64 31 2,000 1,217E-03 0,01039559 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 1,217E-03 0,01035937 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,258E-03 0,01067235 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 1,258E-03 0,01063542 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 1,000 1,258E-03 0,01059875 GO:0016446|somatic hypermutation of immunoglobulin genes, ! regulation of lipid kinase activity GO:0043550 17 8 1,000 1,258E-03 0,01056233 ! signal peptide processing GO:0006465 12 8 1,000 1,258E-03 0,01052616 ! succinate metabolic process GO:0006105 17 8 1,000 1,258E-03 0,01049023 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,258E-03 0,01045455 ! glycerolipid catabolic process GO:0046503 14 8 1,000 1,258E-03 0,01041911 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 1,258E-03 0,01038391 ! pigment granule organization GO:0048753 17 8 1,000 1,258E-03 0,01034895 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,258E-03 0,01031422 ! astrocyte differentiation GO:0048708 19 8 1,000 1,258E-03 0,01027972 ! ER overload response GO:0006983 13 8 1,000 1,258E-03 0,01024546 ! regulation of pigmentation during development GO:0048070 25 8 1,000 1,258E-03 0,01021142 ! melanin metabolic process GO:0006582 17 8 1,000 1,258E-03 0,01017761 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 1,000 1,258E-03 0,01014402 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,258E-03 0,01011065 ! regulation of muscle hypertrophy GO:0014743 12 8 1,000 1,258E-03 0,0100775 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,258E-03 0,01004457 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 1,258E-03 0,01001185 ! Schwann cell differentiation GO:0014037 21 8 1,000 1,258E-03 9,979E-03 ! response to UV-B GO:0010224 17 8 1,000 1,258E-03 9,947E-03 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 1,000 1,258E-03 9,915E-03 ! DNA topological change GO:0006265 12 8 1,000 1,258E-03 9,883E-03 ! response to tumor cell GO:0002347 16 8 1,000 1,258E-03 9,851E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 1,258E-03 9,82E-03 ! positive regulation of smooth muscle contraction GO:0045987 15 8 1,000 1,258E-03 9,789E-03 ! spindle organization GO:0007051 50 32 2,000 1,336E-03 0,01036288 ! metanephros development GO:0001656 81 32 2,000 1,336E-03 0,01033008 ! peripheral nervous system development GO:0007422 68 32 2,000 1,336E-03 0,0102975 ! hindbrain development GO:0030902 65 32 2,000 1,336E-03 0,01026512 ! protein maturation by peptide bond cleavage GO:0051605 118 70 3,000 1,352E-03 0,01035068 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,425E-03 0,01087659 ! regulation of pH GO:0006885 56 33 2,000 1,462E-03 0,01113021 ! response to ionizing radiation GO:0010212 74 33 2,000 1,462E-03 0,01109564 ! actin filament organization GO:0007015 167 72 3,000 1,501E-03 0,01134916 ! B cell activation GO:0042113 179 72 3,000 1,501E-03 0,01131413 ! cell fate specification GO:0001708 56 34 2,000 1,596E-03 0,01199686 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,61E-03 0,01206776 ! neutral lipid catabolic process GO:0046461 14 9 1,000 1,61E-03 0,01203085 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 1,000 1,61E-03 0,01199417 GO:0010469|regulation of receptor activity, ! artery development GO:0060840 25 9 1,000 1,61E-03 0,01195771 GO:0048844|artery morphogenesis, ! regulation of glycolysis GO:0006110 20 9 1,000 1,61E-03 0,01192148 ! microtubule bundle formation GO:0001578 22 9 1,000 1,61E-03 0,01188546 ! T cell selection GO:0045058 27 9 1,000 1,61E-03 0,01184966 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 1,000 1,61E-03 0,01181408 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 1,61E-03 0,01177871 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,61E-03 0,01174355 ! renal water homeostasis GO:0003091 15 9 1,000 1,61E-03 0,0117086 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,61E-03 0,01167385 ! regulation of muscle adaptation GO:0043502 14 9 1,000 1,61E-03 0,01163931 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 3,000 1,661E-03 0,01196673 ! negative regulation of secretion GO:0051048 68 35 2,000 1,737E-03 0,01248004 ! telencephalon development GO:0021537 81 35 2,000 1,737E-03 0,01244344 ! calcium-mediated signaling GO:0019722 67 35 2,000 1,737E-03 0,01240706 ! reproductive structure development GO:0048608 131 75 3,000 1,745E-03 0,01242756 ! regulation of blood pressure GO:0008217 134 76 3,000 1,832E-03 0,01301082 ! negative regulation of hydrolase activity GO:0051346 66 36 2,000 1,885E-03 0,01335031 ! embryonic organ development GO:0048568 67 36 2,000 1,885E-03 0,01331172 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 1,000 2,004E-03 0,01410823 ! regulation of developmental growth GO:0048638 16 10 1,000 2,004E-03 0,01406769 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 2,004E-03 0,01402738 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 2,004E-03 0,01398731 ! positive regulation of heart contraction GO:0045823 17 10 1,000 2,004E-03 0,01394746 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 2,004E-03 0,01390783 ! phosphagen metabolic process GO:0006599 17 10 1,000 2,004E-03 0,01386843 GO:0006600|creatine metabolic process, ! B cell proliferation GO:0042100 19 10 1,000 2,004E-03 0,01382926 ! epithelial cell development GO:0002064 21 10 1,000 2,004E-03 0,0137903 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 2,004E-03 0,01375156 ! motor axon guidance GO:0008045 22 10 1,000 2,004E-03 0,01371305 ! regulation of bone resorption GO:0045124 25 10 1,000 2,004E-03 0,01367474 ! protein heterooligomerization GO:0051291 17 10 1,000 2,004E-03 0,01363665 ! brain morphogenesis GO:0048854 23 10 1,000 2,004E-03 0,01359877 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 2,004E-03 0,0135611 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,004E-03 0,01352364 ! multicellular organismal water homeostasis GO:0050891 16 10 1,000 2,004E-03 0,01348638 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 2,004E-03 0,01344933 GO:0043470|regulation of carbohydrate catabolic process, ! response to nicotine GO:0035094 20 10 1,000 2,004E-03 0,01341249 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 2,000 2,041E-03 0,01362635 ! cell junction organization GO:0034330 96 37 2,000 2,041E-03 0,01358922 ! regulation of microtubule-based process GO:0032886 86 37 2,000 2,041E-03 0,01355229 ! negative regulation of cell activation GO:0050866 69 37 2,000 2,041E-03 0,01351557 ! blood coagulation GO:0007596 151 79 3,000 2,112E-03 0,01394336 GO:0050817|coagulation, ! embryonic skeletal system morphogenesis GO:0048704 68 38 2,000 2,205E-03 0,01452214 ! regulation of protein stability GO:0031647 77 38 2,000 2,205E-03 0,0144831 ! negative regulation of organelle organization GO:0010639 181 80 3,000 2,211E-03 0,01448242 ! mitotic cell cycle checkpoint GO:0007093 76 39 2,000 2,377E-03 0,0155283 ! carbohydrate homeostasis GO:0033500 59 39 2,000 2,377E-03 0,01548689 GO:0042593|glucose homeostasis, ! negative regulation of muscle development GO:0048635 27 11 1,000 2,438E-03 0,01584213 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,438E-03 0,01580011 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,438E-03 0,01575831 ! keratinocyte proliferation GO:0043616 19 11 1,000 2,438E-03 0,01571673 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 2,438E-03 0,01567537 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,438E-03 0,01563423 ! regulation of intracellular pH GO:0051453 21 11 1,000 2,438E-03 0,0155933 ! behavioral fear response GO:0001662 27 11 1,000 2,438E-03 0,01555259 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 1,000 2,438E-03 0,01551208 ! negative regulation of ossification GO:0030279 27 11 1,000 2,438E-03 0,01547179 ! alpha-beta T cell activation GO:0046631 26 11 1,000 2,438E-03 0,01543171 ! vasoconstriction GO:0042310 20 11 1,000 2,438E-03 0,01539184 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 1,000 2,438E-03 0,01535217 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 1,000 2,438E-03 0,0153127 ! neuroblast proliferation GO:0007405 25 11 1,000 2,438E-03 0,01527344 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 1,000 2,438E-03 0,01523437 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 1,000 2,438E-03 0,01519551 ! oocyte development GO:0048599 20 11 1,000 2,438E-03 0,01515685 ! embryonic gut development GO:0048566 19 11 1,000 2,438E-03 0,01511838 ! regulation of embryonic development GO:0045995 35 11 1,000 2,438E-03 0,0150801 ! nucleus organization GO:0006997 73 40 2,000 2,557E-03 0,01577568 ! regulation of action potential in neuron GO:0019228 80 40 2,000 2,557E-03 0,01573595 ! monovalent inorganic cation homeostasis GO:0055067 72 41 2,000 2,745E-03 0,01685121 ! hemostasis GO:0007599 165 85 3,000 2,757E-03 0,01688083 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 2,913E-03 0,01778987 ! virus-host interaction GO:0019048 30 12 1,000 2,913E-03 0,01774551 ! protein complex disassembly GO:0043241 28 12 1,000 2,913E-03 0,01770137 GO:0043624|cellular protein complex disassembly, ! hippocampus development GO:0021766 29 12 1,000 2,913E-03 0,01765744 ! cytokine biosynthetic process GO:0042089 23 12 1,000 2,913E-03 0,01761373 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 1,000 2,913E-03 0,01757024 ! cranial nerve development GO:0021545 23 12 1,000 2,913E-03 0,01752697 ! immunoglobulin production during immune response GO:0002381 24 12 1,000 2,913E-03 0,0174839 ! histone acetylation GO:0016573 27 12 1,000 2,913E-03 0,01744105 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,913E-03 0,01739841 ! T cell homeostasis GO:0043029 28 12 1,000 2,913E-03 0,01735597 ! oocyte differentiation GO:0009994 21 12 1,000 2,913E-03 0,01731374 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 2,913E-03 0,01727172 ! localization within membrane GO:0051668 26 12 1,000 2,913E-03 0,0172299 ! ear morphogenesis GO:0042471 64 42 2,000 2,942E-03 0,01735919 ! T cell differentiation GO:0030217 93 42 2,000 2,942E-03 0,01731736 ! dorsal/ventral pattern formation GO:0009953 75 42 2,000 2,942E-03 0,01727574 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 2,000 3,147E-03 0,01843462 ! glucose transport GO:0015758 66 43 2,000 3,147E-03 0,01839052 ! regulation of T cell proliferation GO:0042129 80 43 2,000 3,147E-03 0,01834663 ! response to reactive oxygen species GO:0000302 75 44 2,000 3,36E-03 0,0195444 ! negative regulation of protein complex disassembly GO:0043242 113 44 2,000 3,36E-03 0,01949798 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 3,36E-03 0,01945177 ! hexose transport GO:0008645 68 44 2,000 3,36E-03 0,01940579 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 2,000 3,36E-03 0,01936002 ! double-strand break repair GO:0006302 85 44 2,000 3,36E-03 0,01931447 ! positive regulation of protein modification process GO:0031401 156 90 3,000 3,389E-03 0,01943316 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 3,427E-03 0,01960681 ! positive regulation of cell growth GO:0030307 24 13 1,000 3,427E-03 0,019561 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 3,427E-03 0,0195154 ! response to X-ray GO:0010165 28 13 1,000 3,427E-03 0,01947001 ! cytokine metabolic process GO:0042107 24 13 1,000 3,427E-03 0,01942484 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 3,427E-03 0,01937988 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 3,427E-03 0,01933512 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 1,000 3,427E-03 0,01929057 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,427E-03 0,01924622 ! histone methylation GO:0016571 29 13 1,000 3,427E-03 0,01920208 ! gland morphogenesis GO:0022612 31 13 1,000 3,427E-03 0,01915814 ! spleen development GO:0048536 24 13 1,000 3,427E-03 0,0191144 ! digestive tract morphogenesis GO:0048546 31 13 1,000 3,427E-03 0,01907086 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! B cell differentiation GO:0030183 124 45 2,000 3,582E-03 0,01988912 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 3,813E-03 0,02112288 ! cell growth GO:0016049 90 46 2,000 3,813E-03 0,02107509 ! female pregnancy GO:0007565 166 94 3,000 3,96E-03 0,02183726 ! hair follicle morphogenesis GO:0031069 27 14 1,000 3,98E-03 0,02190034 ! palate development GO:0060021 32 14 1,000 3,98E-03 0,02185113 ! regulation of heart rate GO:0002027 25 14 1,000 3,98E-03 0,02180213 ! fear response GO:0042596 34 14 1,000 3,98E-03 0,02175336 ! negative regulation of caspase activity GO:0043154 23 14 1,000 3,98E-03 0,0217048 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 3,98E-03 0,02165646 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 1,000 3,98E-03 0,02160834 ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 3,98E-03 0,02156042 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 3,98E-03 0,02151272 ! regulation of cellular pH GO:0030641 27 14 1,000 3,98E-03 0,02146524 ! positive regulation of Ras GTPase activity GO:0032320 42 14 1,000 3,98E-03 0,02141796 ! regulation of T cell activation GO:0050863 175 96 3,000 4,268E-03 0,02291822 ! positive regulation of defense response GO:0031349 88 48 2,000 4,301E-03 0,0230447 ! mitochondrial transport GO:0006839 94 48 2,000 4,301E-03 0,02299427 ! regulation of inflammatory response GO:0050727 84 48 2,000 4,301E-03 0,02294407 ! regulation of protein localization GO:0032880 188 97 3,000 4,429E-03 0,02357119 ! JNK cascade GO:0007254 106 49 2,000 4,559E-03 0,02421322 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 4,572E-03 0,02422893 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 4,572E-03 0,02417649 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 4,572E-03 0,02412427 ! positive regulation of GTPase activity GO:0043547 43 15 1,000 4,572E-03 0,02407228 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 4,572E-03 0,02402051 ! G1/S transition checkpoint GO:0031575 37 15 1,000 4,572E-03 0,02396896 ! water homeostasis GO:0030104 28 15 1,000 4,572E-03 0,02391764 ! cAMP biosynthetic process GO:0006171 25 15 1,000 4,572E-03 0,02386653 ! lymphocyte homeostasis GO:0002260 33 15 1,000 4,572E-03 0,02381564 ! leukocyte differentiation GO:0002521 232 98 3,000 4,593E-03 0,02387307 ! forebrain development GO:0030900 210 98 3,000 4,593E-03 0,02382238 ! regulation of action potential GO:0001508 102 50 2,000 4,826E-03 0,02497914 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 4,826E-03 0,02492633 ! epidermal cell differentiation GO:0009913 87 50 2,000 4,826E-03 0,02487375 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 2,000 5,102E-03 0,02624174 ! negative regulation of immune system process GO:0002683 101 51 2,000 5,102E-03 0,02618661 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 5,202E-03 0,02664178 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 5,202E-03 0,02658604 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 1,000 5,202E-03 0,02653054 ! startle response GO:0001964 28 16 1,000 5,202E-03 0,02647527 ! response to osmotic stress GO:0006970 27 16 1,000 5,202E-03 0,02642023 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 5,202E-03 0,02636541 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 1,000 5,202E-03 0,02631083 ! regulation of protein complex disassembly GO:0043244 127 52 2,000 5,388E-03 0,02719485 ! histone modification GO:0016570 104 52 2,000 5,388E-03 0,02713878 ! metencephalon development GO:0022037 32 17 1,000 5,869E-03 0,02950248 ! negative regulation of hormone secretion GO:0046888 26 17 1,000 5,869E-03 0,0294419 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 5,869E-03 0,02938157 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 5,869E-03 0,02932149 ! signal complex assembly GO:0007172 47 17 1,000 5,869E-03 0,02926165 ! glial cell development GO:0021782 28 17 1,000 5,869E-03 0,02920205 ! regulation of muscle cell differentiation GO:0051147 36 17 1,000 5,869E-03 0,0291427 ! negative regulation of peptidase activity GO:0010466 28 17 1,000 5,869E-03 0,02908359 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 1,000 5,869E-03 0,02902471 ! regulation of survival gene product expression GO:0045884 38 17 1,000 5,869E-03 0,02896608 ! regulation of protein binding GO:0043393 33 17 1,000 5,869E-03 0,02890768 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 5,869E-03 0,02884951 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 5,869E-03 0,02879158 ! activation of phospholipase C activity GO:0007202 110 54 2,000 5,987E-03 0,02931164 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 2,000 5,987E-03 0,02925301 ! epithelial tube morphogenesis GO:0060562 114 54 2,000 5,987E-03 0,02919462 ! positive regulation of phospholipase activity GO:0010518 111 55 2,000 6,301E-03 0,03066457 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 6,301E-03 0,03060361 ! limbic system development GO:0021761 40 18 1,000 6,573E-03 0,03186203 ! regulation of viral genome replication GO:0045069 30 18 1,000 6,573E-03 0,03179894 ! response to retinoic acid GO:0032526 31 18 1,000 6,573E-03 0,0317361 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 1,000 6,573E-03 0,0316735 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 6,573E-03 0,03161115 ! nerve development GO:0021675 34 18 1,000 6,573E-03 0,03154905 ! defense response to virus GO:0051607 43 18 1,000 6,573E-03 0,03148719 ! negative regulation of cytoskeleton organization GO:0051494 139 56 2,000 6,625E-03 0,03167184 ! regulation of bone remodeling GO:0046850 143 57 2,000 6,958E-03 0,03320072 ! regulation of phospholipase activity GO:0010517 113 57 2,000 6,958E-03 0,03313601 ! nucleotide-excision repair GO:0006289 91 57 2,000 6,958E-03 0,03307154 ! regulation of tissue remodeling GO:0034103 146 58 2,000 7,301E-03 0,03463527 ! positive regulation of lipase activity GO:0060193 115 58 2,000 7,301E-03 0,03456814 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 7,314E-03 0,03456017 ! positive regulation of hormone secretion GO:0046887 35 19 1,000 7,314E-03 0,03449346 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 1,000 7,314E-03 0,03442699 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 7,314E-03 0,03436079 ! cerebral cortex development GO:0021987 40 19 1,000 7,314E-03 0,03429484 ! pigmentation during development GO:0048066 42 19 1,000 7,314E-03 0,03422914 ! response to vitamin A GO:0033189 32 19 1,000 7,314E-03 0,03416369 ! neuromuscular junction development GO:0007528 43 19 1,000 7,314E-03 0,03409849 ! visual learning GO:0008542 38 19 1,000 7,314E-03 0,03403354 ! cellular pigmentation GO:0033059 37 19 1,000 7,314E-03 0,03396884 ! peptide biosynthetic process GO:0043043 26 19 1,000 7,314E-03 0,03390438 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 1,000 7,314E-03 0,03384017 ! peptide hormone secretion GO:0030072 32 19 1,000 7,314E-03 0,0337762 ! protein secretion GO:0009306 45 20 1,000 8,09E-03 0,03729125 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 8,09E-03 0,03722102 ! protein amino acid acetylation GO:0006473 41 20 1,000 8,09E-03 0,03715106 ! response to vitamin GO:0033273 36 20 1,000 8,09E-03 0,03708135 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 8,09E-03 0,03701191 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 8,09E-03 0,03694273 ! DNA duplex unwinding GO:0032508 30 20 1,000 8,09E-03 0,03687381 GO:0032392|DNA geometric change, ! body fluid secretion GO:0007589 33 20 1,000 8,09E-03 0,03680514 ! peptide secretion GO:0002790 38 20 1,000 8,09E-03 0,03673673 ! negative regulation of translation GO:0017148 32 20 1,000 8,09E-03 0,03666857 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 8,39E-03 0,03795836 ! viral reproductive process GO:0022415 132 62 2,000 8,773E-03 0,03961772 ! hormone secretion GO:0046879 39 21 1,000 8,902E-03 0,04012445 ! lipid phosphorylation GO:0046834 43 21 1,000 8,902E-03 0,04005056 ! cAMP metabolic process GO:0046058 41 21 1,000 8,902E-03 0,03997694 ! C21-steroid hormone metabolic process GO:0008207 38 21 1,000 8,902E-03 0,03990358 ! ovarian follicle development GO:0001541 39 21 1,000 8,902E-03 0,0398305 ! smooth muscle contraction GO:0006939 48 21 1,000 8,902E-03 0,03975768 ! cellular macromolecular complex disassembly GO:0034623 44 21 1,000 8,902E-03 0,03968513 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 8,902E-03 0,03961285 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 8,902E-03 0,03954082 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 8,902E-03 0,03946906 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 8,902E-03 0,03939756 ! hindlimb morphogenesis GO:0035137 47 22 1,000 9,749E-03 0,04306624 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 9,749E-03 0,0429885 ! cellular response to starvation GO:0009267 37 22 1,000 9,749E-03 0,04291105 ! D-ribose metabolic process GO:0006014 36 22 1,000 9,749E-03 0,04283387 ! ureteric bud development GO:0001657 50 22 1,000 9,749E-03 0,04275697 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 9,749E-03 0,04268034 ! G1 phase GO:0051318 44 22 1,000 9,749E-03 0,04260399 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 9,749E-03 0,04252791 ! positive regulation of B cell activation GO:0050871 42 22 1,000 9,749E-03 0,04245211 ! response to cytokine stimulus GO:0034097 69 22 1,000 9,749E-03 0,04237657 ! activation of JUN kinase activity GO:0007257 47 22 1,000 9,749E-03 0,0423013 ! somatic diversification of immunoglobulins GO:0016445 55 22 1,000 9,749E-03 0,0422263 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 1,000 9,749E-03 0,04215156 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 9,749E-03 0,04207709 ! positive regulation of DNA replication GO:0045740 44 23 1,000 0,01062941 0,04579833 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 0,01062941 0,0457177 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 0,01062941 0,04563736 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 1,000 0,01062941 0,04555729 ! regeneration GO:0031099 42 23 1,000 0,01062941 0,04547751 ! visual behavior GO:0007632 46 23 1,000 0,01062941 0,045398 ! response to ethanol GO:0045471 47 23 1,000 0,01062941 0,04531877 ! deoxyribonucleotide metabolic process GO:0009262 37 23 1,000 0,01062941 0,04523982 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 0,01062941 0,04516114 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 0,01062941 0,04508274 ! hormone transport GO:0009914 41 23 1,000 0,01062941 0,0450046 ! extracellular matrix organization GO:0030198 146 68 2,000 0,0112852 0,04769853 ! viral reproduction GO:0016032 142 68 2,000 0,0112852 0,04761615 ! regulation of lipase activity GO:0060191 137 68 2,000 0,0112852 0,04753405 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 0,01154413 0,04854096 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 1,000 0,01154413 0,04845756 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 1,000 0,01154413 0,04837444 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 0,01154413 0,04829161 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 0,01154413 0,04820906 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 0,01154413 0,04812679 ! sex determination GO:0007530 48 24 1,000 0,01154413 0,0480448 ! regulation of viral reproduction GO:0050792 41 24 1,000 0,01154413 0,04796309 ! membrane depolarization GO:0051899 45 24 1,000 0,01154413 0,04788166 ! oogenesis GO:0048477 44 24 1,000 0,01154413 0,04780051 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 0,01154413 0,04771962 ! pyrimidine nucleoside metabolic process GO:0006213 34 24 1,000 0,01154413 0,04763902 ! germ cell development GO:0007281 133 70 2,000 0,01220509 0,05028166 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 0,01249216 0,05137768 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 0,01249216 0,05129133 ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 0,01249216 0,05120527 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 0,01249216 0,0511195 ! vasculogenesis GO:0001570 49 25 1,000 0,01249216 0,05103402 ! negative regulation of DNA replication GO:0008156 45 25 1,000 0,01249216 0,05094882 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 0,01249216 0,05086391 ! interaction with host GO:0051701 66 25 1,000 0,01249216 0,05077927 ! lymphocyte proliferation GO:0046651 55 25 1,000 0,01249216 0,05069492 ! immunoglobulin production GO:0002377 62 25 1,000 0,01249216 0,05061085 GO:0002440|production of molecular mediator of immune response, ! leukocyte homeostasis GO:0001776 50 25 1,000 0,01249216 0,05052706 ! liver development GO:0001889 55 25 1,000 0,01249216 0,05044354 ! appendage morphogenesis GO:0035107 150 72 2,000 0,01316679 0,05307997 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 2,000 0,01316679 0,05299252 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 0,01347302 0,05413584 ! molting cycle process GO:0022404 52 26 1,000 0,01347302 0,05404694 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 1,000 0,01347302 0,05395834 ! protein amino acid alkylation GO:0008213 59 26 1,000 0,01347302 0,05387003 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 0,01347302 0,05378201 ! spinal cord development GO:0021510 54 26 1,000 0,01347302 0,05369427 ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 0,01347302 0,05360682 ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,01347302 0,05351966 ! osteoblast differentiation GO:0001649 63 26 1,000 0,01347302 0,05343277 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 0,01347302 0,05334617 ! neural crest cell development GO:0014032 59 26 1,000 0,01347302 0,05325985 GO:0014033|neural crest cell differentiation, ! pentose metabolic process GO:0019321 43 26 1,000 0,01347302 0,05317381 ! somatic diversification of immune receptors GO:0002200 63 26 1,000 0,01347302 0,05308805 ! neural tube closure GO:0001843 58 26 1,000 0,01347302 0,05300256 GO:0060606|tube closure, ! appendage development GO:0048736 151 73 2,000 0,0136634 0,05366509 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 2,000 0,0136634 0,05357895 ! tube lumen formation GO:0035148 59 27 1,000 0,01448622 0,05671449 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 0,01448622 0,05662375 ! response to starvation GO:0042594 47 27 1,000 0,01448622 0,0565333 ! response to toxin GO:0009636 49 27 1,000 0,01448622 0,05644313 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01448622 0,05635326 ! cellular response to nutrient levels GO:0031669 45 27 1,000 0,01448622 0,05626366 ! leukocyte proliferation GO:0070661 59 27 1,000 0,01448622 0,05617436 GO:0032943|mononuclear cell proliferation, ! regulation of transcription factor activity GO:0051090 137 75 2,000 0,0146883 0,0568677 GO:0090046|regulation of transcription regulator activity, ! lymphocyte differentiation GO:0030098 193 76 2,000 0,01521664 0,05882002 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01553129 0,05994144 ! dendrite development GO:0016358 67 28 1,000 0,01553129 0,0598469 ! base-excision repair GO:0006284 41 28 1,000 0,01553129 0,05975265 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 1,000 0,01553129 0,0596587 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 0,01553129 0,05956504 ! phosphoinositide metabolic process GO:0030384 146 77 2,000 0,0157556 0,06033062 ! regulation of catabolic process GO:0009894 173 77 2,000 0,0157556 0,0602362 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 0,01630521 0,06224003 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01660773 0,06329593 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01660773 0,06319734 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 0,01660773 0,06309905 ! respiratory gaseous exchange GO:0007585 61 29 1,000 0,01660773 0,06300107 ! primary neural tube formation GO:0014020 61 29 1,000 0,01660773 0,06290339 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01660773 0,06280602 ! somitogenesis GO:0001756 52 29 1,000 0,01660773 0,06270895 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01660773 0,06261217 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 2,000 0,01686547 0,06348591 ! protein oligomerization GO:0051259 149 79 2,000 0,01686547 0,06338824 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 2,000 0,01743642 0,06543345 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 1,000 0,01771509 0,06637724 ! negative regulation of protein kinase cascade GO:0010741 72 30 1,000 0,01771509 0,06627559 ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 0,01771509 0,06617425 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 0,01771509 0,06607322 GO:0048871|multicellular organismal homeostasis, ! ovulation cycle process GO:0022602 55 31 1,000 0,01885289 0,07020976 ! peptide transport GO:0015833 60 31 1,000 0,01885289 0,0701029 ! male gonad development GO:0008584 56 31 1,000 0,01885289 0,06999636 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01885289 0,06989014 ! eye morphogenesis GO:0048592 65 31 1,000 0,01885289 0,06978425 ! response to heat GO:0009408 54 31 1,000 0,01885289 0,06967867 ! response to drug GO:0042493 149 83 2,000 0,01921347 0,07090408 ! T cell activation GO:0042110 189 84 2,000 0,01982725 0,0730588 ! response to nutrient GO:0007584 135 84 2,000 0,01982725 0,07294877 ! regulation of ligase activity GO:0051340 147 84 2,000 0,01982725 0,07283907 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 0,02002067 0,07343917 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 1,000 0,02002067 0,07332907 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,02002067 0,07321929 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,02002067 0,07310985 ! ovulation cycle GO:0042698 57 32 1,000 0,02002067 0,07300073 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,02002067 0,07289194 ! myeloid leukocyte activation GO:0002274 53 32 1,000 0,02002067 0,07278346 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,02002067 0,07267532 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,02045177 0,0741301 ! regulation of cAMP biosynthetic process GO:0030817 173 86 2,000 0,02108703 0,07631944 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,02108703 0,07620654 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,02121797 0,07656647 ! triglyceride metabolic process GO:0006641 46 33 1,000 0,02121797 0,07645354 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,02121797 0,07634094 ! regulation of protein transport GO:0051223 165 87 2,000 0,02173303 0,07807911 GO:0070201|regulation of establishment of protein localization, ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,02244434 0,0805162 ! glial cell differentiation GO:0010001 67 34 1,000 0,02244434 0,08039814 ! post-embryonic development GO:0009791 76 34 1,000 0,02244434 0,08028043 ! GPI anchor biosynthetic process GO:0006506 58 34 1,000 0,02244434 0,08016306 ! adult locomotory behavior GO:0008344 62 34 1,000 0,02244434 0,08004603 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,02244434 0,07992935 ! regulation of cAMP metabolic process GO:0030814 182 89 2,000 0,02305726 0,08199255 ! regulation of DNA binding GO:0051101 167 89 2,000 0,02305726 0,08187338 ! regulation of neurological system process GO:0031644 175 89 2,000 0,02305726 0,08175455 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,02369934 0,08390941 ! GPI anchor metabolic process GO:0006505 61 35 1,000 0,02369934 0,08378798 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 2,000 0,02442445 0,08622679 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 2,000 0,02442445 0,08610236 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,02498252 0,08794279 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 0,02498252 0,08781625 ! negative regulation of DNA binding GO:0043392 67 36 1,000 0,02498252 0,08769008 ! positive regulation of cell development GO:0010720 85 36 1,000 0,02498252 0,08756427 ! regulation of proteolysis GO:0030162 77 36 1,000 0,02498252 0,08743882 ! cytokine production GO:0001816 68 36 1,000 0,02498252 0,08731373 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 1,000 0,02498252 0,08718899 ! bone development GO:0060348 206 92 2,000 0,02512415 0,0875582 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,02629344 0,09150266 ! sister chromatid segregation GO:0000819 65 37 1,000 0,02629344 0,0913725 ! odontogenesis GO:0042476 74 37 1,000 0,02629344 0,09124271 ! female gonad development GO:0008585 71 37 1,000 0,02629344 0,09111329 ! hormone biosynthetic process GO:0042446 62 37 1,000 0,02629344 0,09098423 ! regulation of defense response GO:0031347 171 95 2,000 0,02728758 0,09429073 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 2,000 0,02728758 0,09415755 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,02763166 0,09521037 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 0,02763166 0,09507627 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,02763166 0,09494255 ! neutral lipid metabolic process GO:0006638 54 38 1,000 0,02763166 0,09480921 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 1,000 0,02763166 0,09467623 ! spermatid development GO:0007286 69 38 1,000 0,02763166 0,09454363 ! pigment metabolic process GO:0042440 87 38 1,000 0,02763166 0,09441141 ! neural tube formation GO:0001841 79 38 1,000 0,02763166 0,09427955 ! sex differentiation GO:0007548 171 96 2,000 0,02803013 0,09550573 ! negative regulation of binding GO:0051100 71 39 1,000 0,02899677 0,09866171 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,02899677 0,09852449 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of nucleotide metabolic process GO:0006140 197 98 2,000 0,02954728 0,10025556 ! mammary gland development GO:0030879 93 40 1,000 0,03038833 0,10296627 ! learning GO:0007612 82 40 1,000 0,03038833 0,10282366 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,03038833 0,10268144 GO:0046660|female sex differentiation, ! mismatch repair GO:0006298 58 40 1,000 0,03038833 0,10253961 ! glycerol ether metabolic process GO:0006662 57 40 1,000 0,03038833 0,10239818 ! Rho protein signal transduction GO:0007266 88 40 1,000 0,03038833 0,10225714 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,03110705 0,10453168 GO:0060538|skeletal muscle organ development, ! phosphoinositide biosynthetic process GO:0046489 77 41 1,000 0,03180592 0,10673332 ! regulation of hormone secretion GO:0046883 69 41 1,000 0,03180592 0,10658691 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 1,000 0,03180592 0,1064409 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,03180592 0,10629529 ! gliogenesis GO:0042063 91 41 1,000 0,03180592 0,10615008 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,03180592 0,10600526 ! spermatid differentiation GO:0048515 73 41 1,000 0,03180592 0,10586084 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,03180592 0,10571681 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,03324912 0,1103636 ! organic ether metabolic process GO:0018904 59 42 1,000 0,03324912 0,11021386 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,03324912 0,11006452 ! regulation of protein secretion GO:0050708 77 42 1,000 0,03324912 0,10991558 ! cytokinesis GO:0000910 84 42 1,000 0,03324912 0,10976704 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,03358377 0,1107222 ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03358377 0,11057298 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,03358377 0,11042416 ! neuron fate determination GO:0048664 7 5 0,000 0,03358377 0,11027574 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03358377 0,11012772 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03358377 0,1099801 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,03358377 0,10983287 ! polyol transport GO:0015791 12 5 0,000 0,03358377 0,10968603 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03358377 0,10953959 ! response to superoxide GO:0000303 10 5 0,000 0,03358377 0,10939354 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03358377 0,10924787 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03358377 0,1091026 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,03358377 0,10895771 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03358377 0,1088132 ! female meiosis GO:0007143 10 5 0,000 0,03358377 0,10866908 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,03358377 0,10852534 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03358377 0,10838197 ! hypothalamus development GO:0021854 9 5 0,000 0,03358377 0,10823899 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03358377 0,10809638 ! cobalt ion transport GO:0006824 11 5 0,000 0,03358377 0,10795415 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03358377 0,10781229 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03358377 0,10767081 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03358377 0,10752969 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,03358377 0,10738894 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03358377 0,10724857 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03358377 0,10710856 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03358377 0,10696891 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03358377 0,10682963 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,03358377 0,10669071 ! transposition GO:0032196 9 5 0,000 0,03358377 0,10655215 ! negative chemotaxis GO:0050919 16 5 0,000 0,03358377 0,10641395 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03358377 0,10627611 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03358377 0,10613862 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03358377 0,10600149 ! behavioral response to pain GO:0048266 10 5 0,000 0,03358377 0,10586471 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03358377 0,10572829 ! Notch receptor processing GO:0007220 11 5 0,000 0,03358377 0,10559222 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03358377 0,1054565 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03358377 0,10532112 ! micturition GO:0060073 9 5 0,000 0,03358377 0,10518609 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03358377 0,10505141 ! copulation GO:0007620 9 5 0,000 0,03358377 0,10491708 ! glial cell fate commitment GO:0021781 14 5 0,000 0,03358377 0,10478308 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03358377 0,10464943 ! bioluminescence GO:0008218 9 5 0,000 0,03358377 0,10451612 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03358377 0,10438315 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03358377 0,10425051 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03358377 0,10411822 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03358377 0,10398625 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03358377 0,10385462 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03358377 0,10372333 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03358377 0,10359237 ! grooming behavior GO:0007625 6 5 0,000 0,03358377 0,10346173 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03358377 0,10333143 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03358377 0,10320145 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03358377 0,1030718 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03358377 0,10294248 ! response to protozoan GO:0001562 13 5 0,000 0,03358377 0,10281348 ! lymph vessel development GO:0001945 10 5 0,000 0,03358377 0,1026848 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03358377 0,10255644 ! endochondral ossification GO:0001958 17 5 0,000 0,03358377 0,10242841 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03358377 0,10230069 ! single strand break repair GO:0000012 8 5 0,000 0,03358377 0,10217329 ! parathyroid gland development GO:0060017 14 5 0,000 0,03358377 0,10204621 ! anagen GO:0042640 7 5 0,000 0,03358377 0,10191945 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03358377 0,10179299 ! cytokine secretion GO:0050663 15 5 0,000 0,03358377 0,10166686 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03358377 0,10154103 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03358377 0,10141552 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,03358377 0,10129031 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03358377 0,10116542 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03358377 0,10104083 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03358377 0,10091655 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03358377 0,10079257 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,03358377 0,1006689 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03358377 0,10054553 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03358377 0,10042246 ! microvillus organization GO:0032528 8 5 0,000 0,03358377 0,1002997 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03358377 0,10017723 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,03358377 0,10005507 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03358377 0,0999332 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03358377 0,09981162 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03358377 0,09969034 ! polyol catabolic process GO:0046174 9 5 0,000 0,03358377 0,09956936 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03358377 0,09944867 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03358377 0,09932827 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03358377 0,09920817 ! mitochondrial fission GO:0000266 8 5 0,000 0,03358377 0,09908835 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03358377 0,09896882 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,03358377 0,09884958 ! mRNA transcription GO:0009299 10 5 0,000 0,03358377 0,09873063 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,03358377 0,09861196 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03358377 0,09849358 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03358377 0,09837548 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03358377 0,09825767 ! monocyte activation GO:0042117 10 5 0,000 0,03358377 0,09814014 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03358377 0,09802288 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03358377 0,09790591 ! response to food GO:0032094 6 5 0,000 0,03358377 0,09778922 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03358377 0,0976728 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03358377 0,09755666 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03358377 0,0974408 ! forebrain neuron development GO:0021884 13 5 0,000 0,03358377 0,09732521 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03358377 0,0972099 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,03358377 0,09709486 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,03358377 0,09698009 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03358377 0,09686559 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03358377 0,09675136 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03358377 0,0966374 ! lipid glycosylation GO:0030259 7 5 0,000 0,03358377 0,09652371 ! nucleobase transport GO:0015851 6 5 0,000 0,03358377 0,09641029 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03358377 0,09629713 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03358377 0,09618424 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,03358377 0,09607161 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03358377 0,09595924 ! basic amino acid transport GO:0015802 12 5 0,000 0,03358377 0,09584714 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,03358377 0,0957353 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03358377 0,09562372 ! actin nucleation GO:0045010 11 5 0,000 0,03358377 0,0955124 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03358377 0,09540134 ! depurination GO:0045007 5 5 0,000 0,03358377 0,09529054 ! depyrimidination GO:0045008 10 5 0,000 0,03358377 0,09517999 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03358377 0,0950697 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03358377 0,09495967 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03358377 0,09484989 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03358377 0,09474036 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03358377 0,09463109 ! activated T cell proliferation GO:0050798 16 5 0,000 0,03358377 0,09452207 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03358377 0,0944133 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03358377 0,09430477 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03358377 0,0941965 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03358377 0,09408848 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03358377 0,0939807 ! response to arsenic GO:0046685 11 5 0,000 0,03358377 0,09387317 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,03358377 0,09376589 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03358377 0,09365885 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,03358377 0,09355206 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03358377 0,09344551 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03358377 0,0933392 ! response to mercury ion GO:0046689 8 5 0,000 0,03358377 0,09323313 ! response to cadmium ion GO:0046686 7 5 0,000 0,03358377 0,0931273 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03358377 0,09302172 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03358377 0,09291637 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03358377 0,09281126 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03358377 0,09270639 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03358377 0,09260175 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03358377 0,09249735 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03358377 0,09239319 ! decidualization GO:0046697 11 5 0,000 0,03358377 0,09228926 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03358377 0,09218557 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03358377 0,0920821 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03358377 0,09197887 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03358377 0,09187587 ! embryonic cleavage GO:0040016 6 5 0,000 0,03358377 0,0917731 ! peroxisome fission GO:0016559 5 5 0,000 0,03358377 0,09167056 ! histone demethylation GO:0016577 13 5 0,000 0,03358377 0,09156825 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03358377 0,09146617 ! mitotic recombination GO:0006312 9 5 0,000 0,03358377 0,09136431 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03358377 0,09126268 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03358377 0,09116128 ! metaphase plate congression GO:0051310 7 5 0,000 0,03358377 0,0910601 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03358377 0,09095915 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03358377 0,09085842 ! enteric nervous system development GO:0048484 8 5 0,000 0,03358377 0,09075791 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03358377 0,09065763 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03358377 0,09055756 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,03358377 0,09045772 ! muscle cell proliferation GO:0033002 12 5 0,000 0,03358377 0,0903581 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03358377 0,09025869 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,03358377 0,09015951 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03358377 0,09006054 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03358377 0,08996179 ! metaphase GO:0051323 11 5 0,000 0,03358377 0,08986326 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03358377 0,08976494 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03358377 0,08966683 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03358377 0,08956895 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03358377 0,08947127 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03358377 0,08937381 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03358377 0,08927655 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03358377 0,08917951 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03358377 0,08908269 ! response to redox state GO:0051775 6 5 0,000 0,03358377 0,08898607 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03358377 0,08888966 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03358377 0,08879346 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03358377 0,08869746 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03358377 0,08860168 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03358377 0,0885061 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03358377 0,08841073 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03358377 0,08831556 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03358377 0,0882206 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03358377 0,08812584 ! striatum development GO:0021756 14 5 0,000 0,03358377 0,08803128 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,03358377 0,08793693 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03358377 0,08784278 ! glial cell migration GO:0008347 10 5 0,000 0,03358377 0,08774883 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03358377 0,08765508 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03358377 0,08756153 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03358377 0,08746818 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03358377 0,08737503 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03358377 0,08728208 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03358377 0,08718932 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03358377 0,08709677 ! neuroprotection GO:0043526 8 5 0,000 0,03358377 0,0870044 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,03358377 0,08691224 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03358377 0,08682027 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03358377 0,08672849 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,03358377 0,08663691 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03358377 0,08654552 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03358377 0,08645432 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03358377 0,08636332 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,03358377 0,08627251 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03358377 0,08618188 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03358377 0,08609145 ! spindle assembly GO:0051225 6 5 0,000 0,03358377 0,08600121 ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03358377 0,08591116 ! protein palmitoylation GO:0018345 12 5 0,000 0,03358377 0,08582129 ! drug metabolic process GO:0017144 7 5 0,000 0,03358377 0,08573161 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03358377 0,08564212 ! organ regeneration GO:0031100 7 5 0,000 0,03358377 0,08555282 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03358377 0,0854637 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03358377 0,08537477 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,03471754 0,08816523 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,03471754 0,08807367 ! regulation of tube size GO:0035150 76 43 1,000 0,03471754 0,08798231 GO:0050880|regulation of blood vessel size, ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,03471754 0,08789114 ! neuron migration GO:0001764 85 43 1,000 0,03471754 0,08780015 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 1,000 0,03621075 0,09148176 ! receptor-mediated endocytosis GO:0006898 98 45 1,000 0,03772836 0,09521734 ! keratinocyte differentiation GO:0030216 81 45 1,000 0,03772836 0,09511908 ! biopolymer methylation GO:0043414 91 45 1,000 0,03772836 0,09502102 ! female gamete generation GO:0007292 71 45 1,000 0,03772836 0,09492316 ! developmental growth GO:0048589 88 45 1,000 0,03772836 0,0948255 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,03926997 0,0985987 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04016451 0,10074116 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04016451 0,10063783 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,04016451 0,10053472 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,04016451 0,10043182 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04016451 0,10032913 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,04016451 0,10022665 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,04016451 0,10012438 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04016451 0,10002231 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,04016451 0,09992046 ! response to oxygen radical GO:0000305 11 6 0,000 0,04016451 0,09981881 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,04016451 0,09971737 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,04016451 0,09961613 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,04016451 0,0995151 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,04016451 0,09941427 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04016451 0,09931365 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,04016451 0,09921323 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,04016451 0,09911302 ! forebrain regionalization GO:0021871 9 6 0,000 0,04016451 0,09901301 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04016451 0,09891319 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04016451 0,09881358 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,04016451 0,09871417 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04016451 0,09861496 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,04016451 0,09851595 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04016451 0,09841714 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,04016451 0,09831853 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,04016451 0,09822011 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04016451 0,09812189 ! malate metabolic process GO:0006108 13 6 0,000 0,04016451 0,09802386 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,04016451 0,09792604 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,04016451 0,0978284 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,04016451 0,09773096 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,04016451 0,09763372 ! protein refolding GO:0042026 15 6 0,000 0,04016451 0,09753667 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04016451 0,09743981 ! opsonization GO:0008228 8 6 0,000 0,04016451 0,09734314 ! mating behavior GO:0007617 7 6 0,000 0,04016451 0,09724667 ! erythrocyte maturation GO:0043249 8 6 0,000 0,04016451 0,09715038 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,04016451 0,09705429 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,04016451 0,09695839 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,04016451 0,09686267 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04016451 0,09676715 ! response to interferon-gamma GO:0034341 16 6 0,000 0,04016451 0,09667181 ! toxin metabolic process GO:0009404 11 6 0,000 0,04016451 0,09657666 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04016451 0,0964817 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,04016451 0,09638692 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,04016451 0,09629233 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,04016451 0,09619793 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,04016451 0,09610371 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,04016451 0,09600968 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,04016451 0,09591582 ! thymic T cell selection GO:0045061 16 6 0,000 0,04016451 0,09582216 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,04016451 0,09572867 ! protein lipoylation GO:0009249 10 6 0,000 0,04016451 0,09563537 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,04016451 0,09554225 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,04016451 0,09544931 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,04016451 0,09535655 ! glutamate catabolic process GO:0006538 12 6 0,000 0,04016451 0,09526397 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,04016451 0,09517157 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04016451 0,09507935 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,04016451 0,09498731 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04016451 0,09489544 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,04016451 0,09480376 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,04016451 0,09471225 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,04016451 0,09462091 ! urea metabolic process GO:0019627 7 6 0,000 0,04016451 0,09452976 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04016451 0,09443878 ! neutrophil activation GO:0042119 7 6 0,000 0,04016451 0,09434797 ! regulation of appetite GO:0032098 10 6 0,000 0,04016451 0,09425734 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04016451 0,09416688 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,04016451 0,09407659 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,04016451 0,09398648 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04016451 0,09389654 ! neuron apoptosis GO:0051402 15 6 0,000 0,04016451 0,09380678 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,04016451 0,09371718 ! T cell mediated immunity GO:0002456 17 6 0,000 0,04016451 0,09362776 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04016451 0,0935385 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,04016451 0,09344942 ! carnitine transport GO:0015879 10 6 0,000 0,04016451 0,0933605 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04016451 0,09327176 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,04016451 0,09318318 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,04016451 0,09309477 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,04016451 0,09300653 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,04016451 0,09291845 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04016451 0,09283055 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,04016451 0,09274281 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,04016451 0,09265523 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,04016451 0,09256782 ! response to UV-C GO:0010225 14 6 0,000 0,04016451 0,09248057 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,04016451 0,09239349 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04016451 0,09230657 ! interaction with symbiont GO:0051702 14 6 0,000 0,04016451 0,09221982 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04016451 0,09213323 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,04016451 0,0920468 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,04016451 0,09196053 ! response to copper ion GO:0046688 10 6 0,000 0,04016451 0,09187443 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,04016451 0,09178848 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,04016451 0,0917027 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04016451 0,09161708 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,04016451 0,09153161 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,04016451 0,09144631 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,04016451 0,09136116 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04016451 0,09127618 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,04016451 0,09119135 ! hair follicle maturation GO:0048820 8 6 0,000 0,04016451 0,09110667 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04016451 0,09102216 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,04016451 0,0909378 ! response to pheromone GO:0019236 6 6 0,000 0,04016451 0,0908536 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,04016451 0,09076955 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,04016451 0,09068566 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,04016451 0,09060193 ! subpallium development GO:0021544 15 6 0,000 0,04016451 0,09051835 ! neural tube patterning GO:0021532 8 6 0,000 0,04016451 0,09043492 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,04016451 0,09035165 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,04016451 0,09026853 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04016451 0,09018556 ! G2 phase GO:0051319 16 6 0,000 0,04016451 0,09010274 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,04016451 0,09002008 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,04016451 0,08993757 ! oxygen homeostasis GO:0032364 10 6 0,000 0,04016451 0,08985521 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04016451 0,089773 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,04016451 0,08969094 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04016451 0,08960903 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,04016451 0,08952727 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04016451 0,08944566 ! receptor internalization GO:0031623 11 6 0,000 0,04016451 0,0893642 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,04016451 0,08928288 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,04016451 0,08920172 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,04016451 0,0891207 ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,04016451 0,08903983 ! protein deubiquitination GO:0016579 16 6 0,000 0,04016451 0,0889591 ! protein destabilization GO:0031648 9 6 0,000 0,04016451 0,08887852 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,04016451 0,08879809 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04016451 0,0887178 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,04016451 0,08863766 ! regulation of viral transcription GO:0046782 11 6 0,000 0,04016451 0,08855766 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,04016451 0,08847781 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,04016451 0,0883981 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,04016451 0,08831853 ! determination of adult lifespan GO:0008340 17 6 0,000 0,04016451 0,08823911 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,04016451 0,08815983 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04016451 0,08808069 ! neural plate development GO:0001840 9 6 0,000 0,04016451 0,08800169 ! catecholamine transport GO:0051937 9 6 0,000 0,04016451 0,08792284 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,04016451 0,08784413 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04016451 0,08776555 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,04016451 0,08768712 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,04016451 0,08760883 ! maternal placenta development GO:0001893 12 6 0,000 0,04016451 0,08753068 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,04016451 0,08745266 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04016451 0,08737479 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,04016451 0,08729705 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,04016451 0,08721946 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,04016451 0,087142 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,04016451 0,08706467 GO:0055081|anion homeostasis, ! neural tube development GO:0021915 91 47 1,000 0,04083518 0,08844002 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 1,000 0,0424236 0,09179881 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,0424236 0,09171757 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,0424236 0,09163648 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,0424236 0,09155553 ! male sex differentiation GO:0046661 93 48 1,000 0,0424236 0,09147472 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,0424236 0,09139406 ! methylation GO:0032259 97 48 1,000 0,0424236 0,09131353 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,04403485 0,09469819 ! positive regulation of cyclase activity GO:0031281 106 49 1,000 0,04403485 0,09461491 ! endocrine system development GO:0035270 109 50 1,000 0,04566855 0,0980389 ! regulation of ossification GO:0030278 123 50 1,000 0,04566855 0,09795283 ! immunoglobulin mediated immune response GO:0016064 89 50 1,000 0,04566855 0,09786691 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 1,000 0,04566855 0,09778113 ! tRNA transcription GO:0009304 17 7 0,000 0,04670061 0,09990333 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04670061 0,09981592 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,04670061 0,09972867 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04670061 0,09964157 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,04670061 0,09955462 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04670061 0,09946783 ! sleep GO:0030431 16 7 0,000 0,04670061 0,09938118 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04670061 0,09929469 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04670061 0,09920835 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04670061 0,09912215 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04670061 0,09903611 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04670061 0,09895022 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04670061 0,09886447 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04670061 0,09877887 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04670061 0,09869342 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04670061 0,09860812 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04670061 0,09852297 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04670061 0,09843796 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04670061 0,0983531 ! glycolipid transport GO:0046836 11 7 0,000 0,04670061 0,09826839 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04670061 0,09818382 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,04670061 0,0980994 ! neuron adhesion GO:0007158 14 7 0,000 0,04670061 0,09801512 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04670061 0,09793099 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04670061 0,097847 ! mRNA stabilization GO:0048255 18 7 0,000 0,04670061 0,09776315 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,04670061 0,09767945 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04670061 0,09759589 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04670061 0,09751248 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04670061 0,09742921 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04670061 0,09734607 ! lipoprotein transport GO:0042953 14 7 0,000 0,04670061 0,09726309 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04670061 0,09718024 ! rhythmic behavior GO:0007622 17 7 0,000 0,04670061 0,09709753 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04670061 0,09701497 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04670061 0,09693254 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04670061 0,09685025 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04670061 0,09676811 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04670061 0,0966861 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04670061 0,09660423 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04670061 0,0965225 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04670061 0,09644091 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04670061 0,09635946 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04670061 0,09627814 GO:0045911|positive regulation of DNA recombination, ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04670061 0,09619696 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04670061 0,09611592 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04670061 0,09603502 ! spinal cord patterning GO:0021511 14 7 0,000 0,04670061 0,09595425 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04670061 0,09587361 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04670061 0,09579311 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04670061 0,09571275 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04670061 0,09563252 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04670061 0,09555243 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04670061 0,09547247 ! ovulation GO:0030728 10 7 0,000 0,04670061 0,09539264 ! adenohypophysis development GO:0021984 11 7 0,000 0,04670061 0,09531295 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04670061 0,09523339 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04670061 0,09515396 ! microtubule nucleation GO:0007020 21 7 0,000 0,04670061 0,09507467 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04670061 0,0949955 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04670061 0,09491647 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04670061 0,09483757 ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04670061 0,0947588 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04670061 0,09468017 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04670061 0,09460166 ! galactose metabolic process GO:0006012 13 7 0,000 0,04670061 0,09452328 ! vesicle fusion GO:0006906 20 7 0,000 0,04670061 0,09444503 ! response to dietary excess GO:0002021 8 7 0,000 0,04670061 0,09436691 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04670061 0,09428892 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04670061 0,09421106 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,04670061 0,09413333 ! nucleoside transport GO:0015858 11 7 0,000 0,04670061 0,09405573 ! nucleoside salvage GO:0043174 11 7 0,000 0,04670061 0,09397825 GO:0006166|purine ribonucleoside salvage, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04670061 0,0939009 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04670061 0,09382368 ! parturition GO:0007567 16 7 0,000 0,04670061 0,09374659 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,04670061 0,09366962 ! rRNA modification GO:0000154 14 7 0,000 0,04670061 0,09359278 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04670061 0,09351606 ! spindle checkpoint GO:0031577 16 7 0,000 0,04670061 0,09343948 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,04670061 0,09336301 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04670061 0,09328667 ! monocyte differentiation GO:0030224 16 7 0,000 0,04670061 0,09321046 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04670061 0,09313437 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04670061 0,0930584 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,04670061 0,09298256 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04670061 0,09290684 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04670061 0,09283124 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04670061 0,09275577 ! eating behavior GO:0042755 8 7 0,000 0,04670061 0,09268042 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04670061 0,09260519 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04670061 0,09253009 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04670061 0,0924551 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04670061 0,09238024 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,04670061 0,0923055 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04670061 0,09223088 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04670061 0,09215638 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04670061 0,092082 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04670061 0,09200774 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04670061 0,0919336 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04670061 0,09185958 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,04670061 0,09178568 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04670061 0,0917119 ! histone ubiquitination GO:0016574 9 7 0,000 0,04670061 0,09163823 ! regulation of meiosis GO:0040020 12 7 0,000 0,04670061 0,09156469 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04670061 0,09149126 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04670061 0,09141795 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04670061 0,09134476 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04670061 0,09127168 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04670061 0,09119872 ! anaphase GO:0051322 18 7 0,000 0,04670061 0,09112588 GO:0000090|mitotic anaphase, ! axonal fasciculation GO:0007413 19 7 0,000 0,04670061 0,09105315 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04670061 0,09098054 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04670061 0,09090805 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04670061 0,09083567 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04670061 0,0907634 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04670061 0,09069126 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04670061 0,09061922 ! antibiotic transport GO:0042891 9 7 0,000 0,04670061 0,0905473 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04670061 0,09047549 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04670061 0,0904038 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04670061 0,09033222 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04670061 0,09026076 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04670061 0,09018941 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04670061 0,09011817 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04670061 0,09004704 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04670061 0,08997602 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04670061 0,08990512 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04670061 0,08983433 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04670061 0,08976365 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04670061 0,08969308 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04670061 0,08962262 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04670061 0,08955228 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04670061 0,08948204 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04670061 0,08941191 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04670061 0,08934189 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04670061 0,08927199 ! muscle adaptation GO:0043500 13 7 0,000 0,04670061 0,08920219 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04670061 0,0891325 ! retina homeostasis GO:0001895 12 7 0,000 0,04670061 0,08906292 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04670061 0,08899345 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04670061 0,08892408 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04670061 0,08885483 ! viral infectious cycle GO:0019058 104 51 1,000 0,04732432 0,08997145 ! peptide metabolic process GO:0006518 80 51 1,000 0,04732432 0,08990149 ! response to temperature stimulus GO:0009266 84 51 1,000 0,04732432 0,08983163 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,04732432 0,08976189 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,04900178 0,09287149 ! excretion GO:0007588 87 52 1,000 0,04900178 0,0927995 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,04900178 0,09272762 ! positive regulation of binding GO:0051099 88 52 1,000 0,04900178 0,09265584 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,04900178 0,09258419 ! chromatin remodeling GO:0006338 122 53 1,000 0,05070057 0,09571985 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,05070057 0,09564594 ! vesicle organization GO:0016050 127 53 1,000 0,05070057 0,09557214 ! synapse organization GO:0050808 102 53 1,000 0,05070057 0,09549845 ! neuromuscular process GO:0050905 107 54 1,000 0,05242032 0,09866166 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,05242032 0,09858571 ! protein amino acid lipidation GO:0006497 109 54 1,000 0,05242032 0,09850987 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,0531924 0,09988395 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,0531924 0,09980724 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,0531924 0,09973064 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,0531924 0,09965416 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,0531924 0,09957779 ! male meiosis GO:0007140 9 8 0,000 0,0531924 0,09950155 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,0531924 0,09942542 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,0531924 0,09934941 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,0531924 0,09927351 ! meiotic prophase I GO:0007128 14 8 0,000 0,0531924 0,09919773 ! response to zinc ion GO:0010043 12 8 0,000 0,0531924 0,09912206 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,0531924 0,09904651 ! oligopeptide transport GO:0006857 16 8 0,000 0,0531924 0,09897108 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,0531924 0,09889576 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,0531924 0,09882055 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,0531924 0,09874546 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,0531924 0,09867048 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,0531924 0,09859562 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,0531924 0,09852087 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,0531924 0,09844623 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,0531924 0,0983717 ! estrogen metabolic process GO:0008210 17 8 0,000 0,0531924 0,09829729 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,0531924 0,09822299 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,0531924 0,09814881 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,0531924 0,09807473 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,0531924 0,09800077 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0531924 0,09792692 ! reflex GO:0060004 17 8 0,000 0,0531924 0,09785318 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,0531924 0,09777955 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,0531924 0,09770603 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,0531924 0,09763262 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,0531924 0,09755933 ! histidine catabolic process GO:0006548 10 8 0,000 0,0531924 0,09748614 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,0531924 0,09741306 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,0531924 0,09734009 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,0531924 0,09726723 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,0531924 0,09719448 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,0531924 0,09712184 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,0531924 0,09704931 ! macrophage activation GO:0042116 13 8 0,000 0,0531924 0,09697688 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,0531924 0,09690457 ! purine salvage GO:0043101 12 8 0,000 0,0531924 0,09683236 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,0531924 0,09676025 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0531924 0,09668826 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,0531924 0,09661637 ! osteoblast development GO:0002076 17 8 0,000 0,0531924 0,09654459 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,0531924 0,09647292 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,0531924 0,09640135 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,0531924 0,09632989 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,0531924 0,09625853 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,0531924 0,09618729 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,0531924 0,09611614 ! intermediate filament organization GO:0045109 12 8 0,000 0,0531924 0,0960451 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,0531924 0,09597417 ! cellular extravasation GO:0045123 13 8 0,000 0,0531924 0,09590334 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,0531924 0,09583261 ! response to antibiotic GO:0046677 11 8 0,000 0,0531924 0,09576199 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,0531924 0,09569147 ! response to tropane GO:0014073 15 8 0,000 0,0531924 0,09562106 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,0531924 0,09555075 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,0531924 0,09548055 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,0531924 0,09541044 ! mast cell activation GO:0045576 14 8 0,000 0,0531924 0,09534044 ! multicellular organismal aging GO:0010259 20 8 0,000 0,0531924 0,09527054 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,0531924 0,09520075 ! gas homeostasis GO:0033483 14 8 0,000 0,0531924 0,09513106 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,0531924 0,09506146 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,0531924 0,09499198 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,0531924 0,09492259 ! nucleosome disassembly GO:0006337 14 8 0,000 0,0531924 0,0948533 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,0531924 0,09478412 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,0531924 0,09471503 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,0531924 0,09464605 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,0531924 0,09457716 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,0531924 0,09450838 ! intracellular lipid transport GO:0032365 16 8 0,000 0,0531924 0,0944397 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,0531924 0,09437111 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,0531924 0,09430263 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,0531924 0,09423424 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,0531924 0,09416596 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,0531924 0,09409777 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,0531924 0,09402968 ! hormone catabolic process GO:0042447 17 8 0,000 0,0531924 0,09396169 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,0531924 0,0938938 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,0531924 0,09382601 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,0531924 0,09375831 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,0531924 0,09369072 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,0531924 0,09362321 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,0531924 0,09355581 ! adult feeding behavior GO:0008343 10 8 0,000 0,0531924 0,09348851 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,0531924 0,0934213 ! ATP catabolic process GO:0006200 11 8 0,000 0,0531924 0,09335418 ! blastocyst growth GO:0001832 19 8 0,000 0,0531924 0,09328717 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,0531924 0,09322025 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,0531924 0,09315342 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,0531924 0,09308669 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,0531924 0,09302006 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,0531924 0,09295352 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,0531924 0,09288708 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,0531924 0,09282073 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,0531924 0,09275448 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,0531924 0,09268832 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,0531924 0,09262225 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,0531924 0,09255628 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,0531924 0,09249041 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,0531924 0,09242462 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,0531924 0,09235894 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,0531924 0,09229334 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,0531924 0,09222784 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,0531924 0,09216243 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,0531924 0,09209711 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,0531924 0,09203189 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 1,000 0,05416067 0,09364084 ! cell maturation GO:0048469 107 55 1,000 0,05416067 0,09357461 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,05592125 0,09654814 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,05592125 0,09647996 ! RNA elongation GO:0006354 90 56 1,000 0,05592125 0,09641187 ! muscle fiber development GO:0048747 131 57 1,000 0,05770173 0,09941137 ! heart morphogenesis GO:0003007 105 57 1,000 0,05770173 0,09934132 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,05770173 0,09927136 ! lipoprotein biosynthetic process GO:0042158 115 58 1,000 0,05950174 0,1022961 ! axon extension GO:0048675 16 9 0,000 0,05964015 0,10246195 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,05964015 0,10238994 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,05964015 0,10231804 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05964015 0,10224624 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,05964015 0,10217454 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,05964015 0,10210294 ! reproductive behavior GO:0019098 22 9 0,000 0,05964015 0,10203143 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05964015 0,10196003 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,05964015 0,10188873 ! UTP metabolic process GO:0046051 10 9 0,000 0,05964015 0,10181753 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,05964015 0,10174643 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,05964015 0,10167543 ! regulation of histone modification GO:0031056 14 9 0,000 0,05964015 0,10160453 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,05964015 0,10153372 ! equilibrioception GO:0050957 20 9 0,000 0,05964015 0,10146301 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,05964015 0,10139241 ! chemosensory behavior GO:0007635 21 9 0,000 0,05964015 0,1013219 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,05964015 0,10125149 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05964015 0,10118117 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,05964015 0,10111096 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,05964015 0,10104084 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,05964015 0,10097082 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,05964015 0,10090089 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05964015 0,10083106 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05964015 0,10076133 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,05964015 0,1006917 ! protein targeting to ER GO:0045047 25 9 0,000 0,05964015 0,10062216 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,05964015 0,10055272 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,05964015 0,10048337 ! glycine catabolic process GO:0006546 15 9 0,000 0,05964015 0,10041412 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,05964015 0,10034496 ! endosome organization GO:0007032 20 9 0,000 0,05964015 0,1002759 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05964015 0,10020694 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,05964015 0,10013807 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05964015 0,10006929 ! mannose metabolic process GO:0006013 13 9 0,000 0,05964015 0,10000061 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,05964015 0,09993202 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,05964015 0,09986353 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,05964015 0,09979513 ! receptor clustering GO:0043113 20 9 0,000 0,05964015 0,09972682 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,05964015 0,09965861 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05964015 0,09959049 ! retinol metabolic process GO:0042572 20 9 0,000 0,05964015 0,09952247 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,05964015 0,09945453 ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,05964015 0,09938669 ! macrophage differentiation GO:0030225 15 9 0,000 0,05964015 0,09931894 ! oligodendrocyte development GO:0014003 11 9 0,000 0,05964015 0,09925129 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,05964015 0,09918372 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05964015 0,09911625 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,05964015 0,09904887 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05964015 0,09898158 ! response to amine stimulus GO:0014075 13 9 0,000 0,05964015 0,09891438 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05964015 0,09884728 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,05964015 0,09878026 ! erythrocyte development GO:0048821 17 9 0,000 0,05964015 0,09871334 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05964015 0,09864651 ! postreplication repair GO:0006301 25 9 0,000 0,05964015 0,09857976 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,05964015 0,09851311 ! icosanoid secretion GO:0032309 15 9 0,000 0,05964015 0,09844655 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05964015 0,09838007 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,05964015 0,09831369 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,05964015 0,0982474 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,05964015 0,09818119 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05964015 0,09811508 ! sterol catabolic process GO:0016127 14 9 0,000 0,05964015 0,09804905 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05964015 0,09798311 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,05964015 0,09791726 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,05964015 0,0978515 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,05964015 0,09778583 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,05964015 0,09772025 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,05964015 0,09765475 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,05964015 0,09758934 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,05964015 0,09752402 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,05964015 0,09745879 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,05964015 0,09739364 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05964015 0,09732858 ! purine base metabolic process GO:0006144 25 9 0,000 0,05964015 0,09726361 ! pigment granule transport GO:0051904 17 9 0,000 0,05964015 0,09719873 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,05964015 0,09713393 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,05964015 0,09706921 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,05964015 0,09700459 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,05964015 0,09694005 ! mitochondrion localization GO:0051646 18 9 0,000 0,05964015 0,09687559 ! establishment of organelle localization GO:0051656 122 59 1,000 0,06132095 0,09953959 ! lipid modification GO:0030258 112 60 1,000 0,06315901 0,10245515 ! adult behavior GO:0030534 104 60 1,000 0,06315901 0,10238716 ! positive regulation of secretion GO:0051047 110 61 1,000 0,06501557 0,10532695 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,06501557 0,10525715 ! camera-type eye development GO:0043010 126 61 1,000 0,06501557 0,10518744 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,06604418 0,10678089 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,06604418 0,10671027 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,06604418 0,10663974 ! associative learning GO:0008306 21 10 0,000 0,06604418 0,1065693 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,06604418 0,10649896 ! phosphate transport GO:0006817 24 10 0,000 0,06604418 0,10642871 ! cell volume homeostasis GO:0006884 17 10 0,000 0,06604418 0,10635855 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,06604418 0,10628849 ! CTP metabolic process GO:0046036 11 10 0,000 0,06604418 0,10621852 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,06604418 0,10614864 ! GTP metabolic process GO:0046039 11 10 0,000 0,06604418 0,10607885 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,06604418 0,10600915 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,06604418 0,10593954 ! social behavior GO:0035176 29 10 0,000 0,06604418 0,10587003 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,06604418 0,10580061 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,06604418 0,10573128 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,06604418 0,10566203 ! androgen metabolic process GO:0008209 17 10 0,000 0,06604418 0,10559288 ! phospholipid efflux GO:0033700 19 10 0,000 0,06604418 0,10552382 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,06604418 0,10545485 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,06604418 0,10538597 ! lung alveolus development GO:0048286 26 10 0,000 0,06604418 0,10531718 ! pathogenesis GO:0009405 17 10 0,000 0,06604418 0,10524848 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06604418 0,10517987 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,06604418 0,10511135 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,06604418 0,10504292 ! endoderm development GO:0007492 18 10 0,000 0,06604418 0,10497458 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,06604418 0,10490632 ! arginine catabolic process GO:0006527 17 10 0,000 0,06604418 0,10483816 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,06604418 0,10477008 ! proline metabolic process GO:0006560 13 10 0,000 0,06604418 0,10470209 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,06604418 0,10463419 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,06604418 0,10456638 ! V(D)J recombination GO:0033151 34 10 0,000 0,06604418 0,10449866 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,06604418 0,10443102 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,06604418 0,10436347 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,06604418 0,10429601 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,06604418 0,10422863 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,06604418 0,10416135 ! multicellular organism growth GO:0035264 19 10 0,000 0,06604418 0,10409415 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,06604418 0,10402703 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,06604418 0,10396 ! ruffle organization GO:0031529 17 10 0,000 0,06604418 0,10389306 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,06604418 0,10382621 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,06604418 0,10375944 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,06604418 0,10369275 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,06604418 0,10362616 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,06604418 0,10355964 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,06604418 0,10349322 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,06604418 0,10342688 ! segment specification GO:0007379 15 10 0,000 0,06604418 0,10336062 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,06604418 0,10329445 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,06604418 0,10322836 ! response to dsRNA GO:0043331 23 10 0,000 0,06604418 0,10316236 ! DNA ligation GO:0006266 18 10 0,000 0,06604418 0,10309644 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,06604418 0,1030306 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,06604418 0,10296485 ! melanosome localization GO:0032400 16 10 0,000 0,06604418 0,10289919 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,06604418 0,1028336 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,06604418 0,10276811 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,06604418 0,10270269 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,06604418 0,10263736 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,06604418 0,10257211 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,06604418 0,10250694 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,06604418 0,10244186 ! protein sumoylation GO:0016925 17 10 0,000 0,06604418 0,10237686 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,06604418 0,10231194 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,06604418 0,1022471 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,06604418 0,10218235 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,06604418 0,10211767 ! salivary gland development GO:0007431 28 10 0,000 0,06604418 0,10205308 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,06604418 0,10198858 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,06604418 0,10192415 ! midbrain development GO:0030901 14 10 0,000 0,06604418 0,1018598 ! musculoskeletal movement GO:0050881 16 10 0,000 0,06604418 0,10179554 GO:0050879|multicellular organismal movement, ! methionine biosynthetic process GO:0009086 21 10 0,000 0,06604418 0,10173135 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,06604418 0,10166725 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,06604418 0,10160323 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,06604418 0,10153929 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,06604418 0,10147542 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,06604418 0,10141164 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,06604418 0,10134794 ! detection of calcium ion GO:0005513 24 10 0,000 0,06604418 0,10128432 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,06604418 0,10122078 ! blastocyst formation GO:0001825 18 10 0,000 0,06604418 0,10115732 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,06604418 0,10109394 ! cerebellar cortex development GO:0021695 16 10 0,000 0,06604418 0,10103064 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,06604418 0,10096741 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,06604418 0,10090427 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,06604418 0,1008412 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,06604418 0,10077822 ! nucleoside metabolic process GO:0009116 91 62 1,000 0,06689031 0,10200564 ! glycerophospholipid biosynthetic process GO:0046474 116 64 1,000 0,07069301 0,10773737 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,07069301 0,10767021 ! respiratory burst GO:0045730 17 11 0,000 0,07240477 0,11020863 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,07240477 0,11014001 ! neuron fate specification GO:0048665 18 11 0,000 0,07240477 0,11007147 ! telencephalon cell migration GO:0022029 23 11 0,000 0,07240477 0,11000302 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,07240477 0,10993465 ! thyroid gland development GO:0030878 26 11 0,000 0,07240477 0,10986637 ! synapsis GO:0007129 14 11 0,000 0,07240477 0,10979817 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,07240477 0,10973006 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,07240477 0,10966203 ! response to pain GO:0048265 27 11 0,000 0,07240477 0,10959409 ! blood vessel remodeling GO:0001974 30 11 0,000 0,07240477 0,10952623 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,07240477 0,10945845 ! bone resorption GO:0045453 16 11 0,000 0,07240477 0,10939076 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,07240477 0,10932315 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07240477 0,10925562 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07240477 0,10918818 ! melanocyte differentiation GO:0030318 20 11 0,000 0,07240477 0,10912082 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,07240477 0,10905355 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,07240477 0,10898636 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,07240477 0,10891925 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,07240477 0,10885222 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,07240477 0,10878527 ! adult heart development GO:0007512 16 11 0,000 0,07240477 0,10871841 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07240477 0,10865163 ! macroautophagy GO:0016236 19 11 0,000 0,07240477 0,10858493 ! temperature homeostasis GO:0001659 18 11 0,000 0,07240477 0,10851832 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,07240477 0,10845178 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,07240477 0,10838533 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,07240477 0,10831896 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,07240477 0,10825266 ! regulation of organ growth GO:0046620 14 11 0,000 0,07240477 0,10818646 ! pigment granule localization GO:0051875 20 11 0,000 0,07240477 0,10812033 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,07240477 0,10805428 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,07240477 0,10798831 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07240477 0,10792242 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,07240477 0,10785662 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,07240477 0,10779089 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,07240477 0,10772525 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,07240477 0,10765968 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,07240477 0,10759419 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,07240477 0,10752879 ! prophase GO:0051324 17 11 0,000 0,07240477 0,10746346 ! nucleosome positioning GO:0016584 15 11 0,000 0,07240477 0,10739821 ! regulation of isotype switching GO:0045191 24 11 0,000 0,07240477 0,10733304 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,07240477 0,10726795 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,07240477 0,10720294 ! apical protein localization GO:0045176 18 11 0,000 0,07240477 0,10713801 ! acid secretion GO:0046717 20 11 0,000 0,07240477 0,10707316 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07240477 0,10700838 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,07240477 0,10694368 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,07240477 0,10687907 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,07240477 0,10681453 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,07240477 0,10675006 ! cholesterol efflux GO:0033344 21 11 0,000 0,07240477 0,10668568 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07240477 0,10662137 ! germ cell migration GO:0008354 26 11 0,000 0,07240477 0,10655714 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,07240477 0,10649299 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,07240477 0,10642891 ! activation of innate immune response GO:0002218 16 11 0,000 0,07240477 0,10636492 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,07240477 0,10630099 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,07240477 0,10623715 ! lysogeny GO:0030069 22 11 0,000 0,07240477 0,10617338 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07240477 0,10610969 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,07240477 0,10604608 ! sequestering of metal ion GO:0051238 15 11 0,000 0,07240477 0,10598254 ! nucleus localization GO:0051647 22 11 0,000 0,07240477 0,10591907 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,0726203 0,1061708 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,0726203 0,1061073 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,0726203 0,10604387 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 1,000 0,0726203 0,10598053 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,07456447 0,10875284 ! gonad development GO:0008406 115 66 1,000 0,07456447 0,10868795 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,0765252 0,11147947 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 1,000 0,0765252 0,11141303 ! secondary metabolic process GO:0019748 125 67 1,000 0,0765252 0,11134667 ! myeloid cell differentiation GO:0030099 126 67 1,000 0,0765252 0,1112804 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,07850217 0,11408733 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,07850217 0,1140195 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,07850217 0,11395175 ! adaptive immune response GO:0002250 126 68 1,000 0,07850217 0,11388409 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,07850217 0,1138165 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,07872222 0,11406785 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,07872222 0,11400023 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,07872222 0,1139327 ! mating GO:0007618 17 12 0,000 0,07872222 0,11386524 ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,07872222 0,11379786 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,07872222 0,11373057 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,07872222 0,11366335 ! T cell proliferation GO:0042098 32 12 0,000 0,07872222 0,11359621 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,07872222 0,11352916 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,07872222 0,11346218 ! ventral spinal cord development GO:0021517 25 12 0,000 0,07872222 0,11339528 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,07872222 0,11332846 ! drug transport GO:0015893 16 12 0,000 0,07872222 0,11326171 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,07872222 0,11319505 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,07872222 0,11312847 ! polyamine metabolic process GO:0006595 18 12 0,000 0,07872222 0,11306196 ! mitotic spindle organization GO:0007052 23 12 0,000 0,07872222 0,11299553 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,07872222 0,11292918 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,07872222 0,11286291 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,07872222 0,11279671 ! lipid digestion GO:0044241 21 12 0,000 0,07872222 0,11273059 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,07872222 0,11266455 ! entry into host cell GO:0030260 34 12 0,000 0,07872222 0,11259859 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07872222 0,1125327 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,07872222 0,1124669 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,07872222 0,11240116 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,07872222 0,11233551 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,07872222 0,11226993 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,07872222 0,11220443 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,07872222 0,112139 ! snRNA metabolic process GO:0016073 30 12 0,000 0,07872222 0,11207365 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,07872222 0,11200838 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,07872222 0,11194318 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,07872222 0,11187806 ! fucose catabolic process GO:0019317 25 12 0,000 0,07872222 0,11181302 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 24 12 0,000 0,07872222 0,11174805 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,07872222 0,11168315 ! zymogen activation GO:0031638 18 12 0,000 0,07872222 0,11161833 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,07872222 0,11155359 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,07872222 0,11148892 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,07872222 0,11142433 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,07872222 0,11135981 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,07872222 0,11129537 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,07872222 0,111231 ! defense response to fungus GO:0050832 15 12 0,000 0,07872222 0,1111667 ! embryonic placenta development GO:0001892 21 12 0,000 0,07872222 0,11110248 ! lamellipodium assembly GO:0030032 24 12 0,000 0,07872222 0,11103833 ! response to cold GO:0009409 17 12 0,000 0,07872222 0,11097426 ! establishment of cell polarity GO:0030010 21 12 0,000 0,07872222 0,11091026 ! regulation of synapse organization GO:0050807 18 12 0,000 0,07872222 0,11084633 ! cellular hormone metabolic process GO:0034754 120 69 1,000 0,08049507 0,11327734 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,08049507 0,11321213 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,08049507 0,11314699 ! developmental maturation GO:0021700 128 69 1,000 0,08049507 0,11308192 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,08499683 0,1193375 ! cGMP metabolic process GO:0046068 18 13 0,000 0,08499683 0,11926895 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,08499683 0,11920049 ! regulation of chemokine production GO:0032642 18 13 0,000 0,08499683 0,1191321 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,08499683 0,11906379 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,08499683 0,11899556 ! peroxisomal transport GO:0043574 28 13 0,000 0,08499683 0,1189274 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,08499683 0,11885933 ! cartilage condensation GO:0001502 22 13 0,000 0,08499683 0,11879133 ! organelle fusion GO:0048284 36 13 0,000 0,08499683 0,11872341 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,08499683 0,11865557 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,08499683 0,11858781 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,08499683 0,11852012 ! endocrine pancreas development GO:0031018 25 13 0,000 0,08499683 0,11845251 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,08499683 0,11838498 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,08499683 0,11831752 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,08499683 0,11825014 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,08499683 0,11818284 ! methionine metabolic process GO:0006555 31 13 0,000 0,08499683 0,11811561 ! plasma membrane organization GO:0007009 27 13 0,000 0,08499683 0,11804846 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,08499683 0,11798139 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,08499683 0,11791439 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,08499683 0,11784747 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,08499683 0,11778063 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,08499683 0,11771386 ! exocrine system development GO:0035272 34 13 0,000 0,08499683 0,11764717 ! asymmetric protein localization GO:0008105 24 13 0,000 0,08499683 0,11758055 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,08499683 0,11751401 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,08499683 0,11744754 ! L-glutamate transport GO:0015813 30 13 0,000 0,08499683 0,11738115 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,08499683 0,11731483 ! protein homotetramerization GO:0051289 24 13 0,000 0,08499683 0,11724859 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,08499683 0,11718242 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,08499683 0,11711633 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,08499683 0,11705031 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,08499683 0,11698437 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,08499683 0,1169185 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,08499683 0,1168527 ! chromatin silencing GO:0006342 29 13 0,000 0,08499683 0,11678698 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,08499683 0,11672133 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,08499683 0,11665576 ! regulation of epidermis development GO:0045682 19 13 0,000 0,08499683 0,11659026 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,08499683 0,11652483 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,08499683 0,11645948 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,08499683 0,1163942 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,08499683 0,11632899 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,08499683 0,11626386 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,08499683 0,1161988 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,08499683 0,11613381 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,08499683 0,11606889 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,08499683 0,11600405 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,08499683 0,11593928 ! insulin secretion GO:0030073 24 13 0,000 0,08499683 0,11587458 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,08499683 0,11580995 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,08499683 0,1157454 ! acrosome reaction GO:0007340 19 13 0,000 0,08499683 0,11568092 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,08499683 0,11561651 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,08499683 0,11555217 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,08656633 0,11762044 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,08656633 0,11755506 ! glycerolipid biosynthetic process GO:0045017 130 73 1,000 0,08861993 0,12027694 ! organelle localization GO:0051640 155 74 1,000 0,09068797 0,12301539 ! rRNA transcription GO:0009303 28 14 0,000 0,09122887 0,12368043 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,09122887 0,12361183 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,09122887 0,12354331 ! water transport GO:0006833 21 14 0,000 0,09122887 0,12347487 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,09122887 0,1234065 ! non-recombinational repair GO:0000726 29 14 0,000 0,09122887 0,1233382 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,09122887 0,12326998 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,09122887 0,12320184 ! RNA polyadenylation GO:0043631 32 14 0,000 0,09122887 0,12313377 ! lipid localization GO:0010876 32 14 0,000 0,09122887 0,12306578 GO:0019915|lipid storage, ! regulated secretory pathway GO:0045055 24 14 0,000 0,09122887 0,12299787 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,09122887 0,12293002 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,09122887 0,12286226 ! arginine metabolic process GO:0006525 21 14 0,000 0,09122887 0,12279456 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,09122887 0,12272695 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,09122887 0,1226594 ! organic alcohol transport GO:0015850 29 14 0,000 0,09122887 0,12259193 ! neutral amino acid transport GO:0015804 28 14 0,000 0,09122887 0,12252454 ! bone mineralization GO:0030282 18 14 0,000 0,09122887 0,12245722 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,09122887 0,12238997 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,09122887 0,1223228 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,09122887 0,1222557 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,09122887 0,12218867 ! ribosome assembly GO:0042255 18 14 0,000 0,09122887 0,12212172 ! cerebellum development GO:0021549 23 14 0,000 0,09122887 0,12205484 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,09122887 0,12198803 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,09122887 0,1219213 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,09122887 0,12185464 ! NADP metabolic process GO:0006739 24 14 0,000 0,09122887 0,12178805 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,09122887 0,12172154 ! oxygen transport GO:0015671 22 14 0,000 0,09122887 0,12165509 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,09122887 0,12158872 ! male genitalia development GO:0030539 26 14 0,000 0,09122887 0,12152243 ! regulation of RNA stability GO:0043487 33 14 0,000 0,09122887 0,1214562 ! regulation of axon extension GO:0030516 43 14 0,000 0,09122887 0,12139005 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,09122887 0,12132397 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,09122887 0,12125796 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,09277015 0,12323953 ! axon guidance GO:0007411 162 75 1,000 0,09277015 0,12317255 ! rhythmic process GO:0048511 142 75 1,000 0,09277015 0,12310564 ! eye development GO:0001654 155 75 1,000 0,09277015 0,12303881 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,0948662 0,12575047 ! learning or memory GO:0007611 161 76 1,000 0,0948662 0,12568228 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 1,000 0,0948662 0,12561415 ! cytosolic calcium ion homeostasis GO:0051480 149 77 1,000 0,09697581 0,12833798 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,09697581 0,12826849 ! lactation GO:0007595 30 15 0,000 0,09741864 0,12878449 ! reproductive cellular process GO:0048610 22 15 0,000 0,09741864 0,12871484 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,09741864 0,12864527 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,09741864 0,12857577 ! superoxide anion generation GO:0042554 22 15 0,000 0,09741864 0,12850634 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,09741864 0,12843699 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,09741864 0,12836772 ! copper ion transport GO:0006825 22 15 0,000 0,09741864 0,12829852 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,09741864 0,12822939 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,09741864 0,12816034 ! sulfate transport GO:0008272 27 15 0,000 0,09741864 0,12809136 ! response to cAMP GO:0051591 25 15 0,000 0,09741864 0,12802246 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,09741864 0,12795363 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,09741864 0,12788487 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,09741864 0,12781619 ! response to hexose stimulus GO:0009746 25 15 0,000 0,09741864 0,12774758 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,09741864 0,12767905 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,09741864 0,12761059 ! vesicle coating GO:0006901 38 15 0,000 0,09741864 0,1275422 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,09741864 0,12747389 ! regulation of exocytosis GO:0017157 26 15 0,000 0,09741864 0,12740565 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,09741864 0,12733748 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,09741864 0,12726938 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,09741864 0,12720136 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,09741864 0,12713341 ! regulation of vasodilation GO:0042312 27 15 0,000 0,09741864 0,12706553 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,09741864 0,12699773 ! histone deacetylation GO:0016575 24 15 0,000 0,09741864 0,12693 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,09741864 0,12686234 ! cofactor transport GO:0051181 30 15 0,000 0,09741864 0,12679475 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,09741864 0,12672723 ! muscle maintenance GO:0046716 26 15 0,000 0,09741864 0,12665979 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,09741864 0,12659242 ! intestinal absorption GO:0050892 31 15 0,000 0,09741864 0,12652512 ! dopamine metabolic process GO:0042417 35 15 0,000 0,09741864 0,12645789 ! heme biosynthetic process GO:0006783 33 15 0,000 0,09741864 0,12639073 ! cell killing GO:0001906 32 15 0,000 0,09741864 0,12632364 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,09741864 0,12625663 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,09741864 0,12618969 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,09741864 0,12612281 ! actin filament polymerization GO:0030041 27 15 0,000 0,09741864 0,12605601 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,09741864 0,12598928 ! lipoprotein metabolic process GO:0042157 147 78 1,000 0,09909872 0,12809427 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,10123465 0,13078596 ! steroid biosynthetic process GO:0006694 146 79 1,000 0,10123465 0,13071683 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,10123465 0,13064778 ! regulation of synaptic transmission GO:0050804 159 79 1,000 0,10123465 0,1305788 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,10338332 0,13327992 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,10356643 0,13344556 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,10356643 0,13337522 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,10356643 0,13330495 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,10356643 0,13323475 ! bone remodeling GO:0046849 28 16 0,000 0,10356643 0,13316463 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,10356643 0,13309458 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10356643 0,1330246 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,10356643 0,1329547 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,10356643 0,13288487 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,10356643 0,13281511 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,10356643 0,13274543 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,10356643 0,13267582 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,10356643 0,13260628 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,10356643 0,13253682 ! protein polyubiquitination GO:0000209 41 16 0,000 0,10356643 0,13246743 ! glutamate metabolic process GO:0006536 25 16 0,000 0,10356643 0,13239811 ! pituitary gland development GO:0021983 30 16 0,000 0,10356643 0,13232886 ! lysosomal transport GO:0007041 31 16 0,000 0,10356643 0,13225969 ! fructose metabolic process GO:0006000 25 16 0,000 0,10356643 0,13219059 ! L-amino acid transport GO:0015807 33 16 0,000 0,10356643 0,13212156 ! stem cell development GO:0048864 46 16 0,000 0,10356643 0,1320526 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,10356643 0,13198372 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,10356643 0,1319149 ! intermediate filament-based process GO:0045103 36 16 0,000 0,10356643 0,13184616 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,10356643 0,13177749 ! negative regulation of immune response GO:0050777 38 16 0,000 0,10356643 0,1317089 ! axon cargo transport GO:0008088 46 16 0,000 0,10356643 0,13164037 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,10356643 0,13157191 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,10356643 0,13150353 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,10356643 0,13143521 ! DNA replication initiation GO:0006270 28 16 0,000 0,10356643 0,13136697 ! neuron recognition GO:0008038 40 16 0,000 0,10356643 0,1312988 ! mRNA splice site selection GO:0006376 44 16 0,000 0,10356643 0,1312307 ! tissue regeneration GO:0042246 27 16 0,000 0,10356643 0,13116267 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,10356643 0,13109471 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,10356643 0,13102682 ! biomineral formation GO:0031214 22 16 0,000 0,10356643 0,130959 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,10356643 0,13089125 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,10356643 0,13082357 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,10356643 0,13075596 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,10356643 0,13068842 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,10356643 0,13062095 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,10356643 0,13055355 ! protein import into nucleus GO:0006606 174 82 1,000 0,10771782 0,13571668 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,10967251 0,13810822 ! filopodium assembly GO:0046847 42 17 0,000 0,10967251 0,13803707 ! endothelial cell migration GO:0043542 31 17 0,000 0,10967251 0,13796599 ! gene silencing by RNA GO:0031047 38 17 0,000 0,10967251 0,13789498 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,10967251 0,13782405 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,10967251 0,13775319 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,10967251 0,1376824 ! myoblast differentiation GO:0045445 50 17 0,000 0,10967251 0,13761168 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,10967251 0,13754104 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,10967251 0,13747047 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,10967251 0,13739997 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,10967251 0,13732955 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,10967251 0,1372592 ! NAD metabolic process GO:0019674 33 17 0,000 0,10967251 0,13718891 ! membrane budding GO:0006900 42 17 0,000 0,10967251 0,1371187 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,10967251 0,13704857 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,10967251 0,1369785 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,10967251 0,13690851 ! genitalia development GO:0048806 32 17 0,000 0,10967251 0,13683858 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,10967251 0,13676873 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,10967251 0,13669895 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,10967251 0,13662924 ! steroid catabolic process GO:0006706 34 17 0,000 0,10967251 0,13655961 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,10967251 0,13649004 ! gas transport GO:0015669 26 17 0,000 0,10967251 0,13642054 ! organic cation transport GO:0015695 32 17 0,000 0,10967251 0,13635112 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,10967251 0,13628176 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,10967251 0,13621248 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,10990311 0,13642953 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,10990311 0,13636024 ! nuclear import GO:0051170 177 83 1,000 0,10990311 0,13629102 ! response to metal ion GO:0010038 158 84 1,000 0,11210009 0,13894496 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,11430848 0,14161035 ! regulation of transmission of nerve impulse GO:0051969 167 85 1,000 0,11430848 0,14153858 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,11573717 0,14323501 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,11573717 0,14316249 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,11573717 0,14309004 ! negative regulation of ion transport GO:0043271 25 18 0,000 0,11573717 0,14301766 ! adult walking behavior GO:0007628 36 18 0,000 0,11573717 0,14294536 ! heart looping GO:0001947 34 18 0,000 0,11573717 0,14287313 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,11573717 0,14280097 ! centrosome cycle GO:0007098 26 18 0,000 0,11573717 0,14272888 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,11573717 0,14265687 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,11573717 0,14258493 ! glycine metabolic process GO:0006544 30 18 0,000 0,11573717 0,14251306 ! glutamine metabolic process GO:0006541 29 18 0,000 0,11573717 0,14244127 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,11573717 0,14236955 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,11573717 0,1422979 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,11573717 0,14222632 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,11573717 0,14215481 ! neural crest cell migration GO:0001755 41 18 0,000 0,11573717 0,14208338 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,11573717 0,14201201 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,11573717 0,14194072 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,11573717 0,1418695 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,11573717 0,14179835 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,11573717 0,14172728 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,11573717 0,14165627 ! detection of bacterium GO:0016045 22 18 0,000 0,11573717 0,14158534 ! microspike assembly GO:0030035 46 18 0,000 0,11573717 0,14151447 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,11573717 0,14144368 ! regulation of lyase activity GO:0051339 169 86 1,000 0,11652804 0,142339 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,12099964 0,1477272 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,1217607 0,14858211 ! positive regulation of translation GO:0045727 31 19 0,000 0,1217607 0,14850793 ! negative regulation of defense response GO:0031348 27 19 0,000 0,1217607 0,14843382 ! neuron maturation GO:0042551 46 19 0,000 0,1217607 0,14835979 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,1217607 0,14828583 ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,1217607 0,14821195 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,1217607 0,14813814 ! inositol metabolic process GO:0006020 33 19 0,000 0,1217607 0,1480644 ! memory GO:0007613 34 19 0,000 0,1217607 0,14799074 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,1217607 0,14791715 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,1217607 0,14784363 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,1217607 0,14777018 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,1217607 0,14769681 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,1217607 0,14762351 ! heme metabolic process GO:0042168 40 19 0,000 0,1217607 0,14755029 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,1217607 0,14747713 ! response to fungus GO:0009620 26 19 0,000 0,1217607 0,14740405 ! peptide cross-linking GO:0018149 39 19 0,000 0,1217607 0,14733105 ! protein export from nucleus GO:0006611 40 19 0,000 0,1217607 0,14725811 ! heart process GO:0003015 32 19 0,000 0,1217607 0,14718524 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,1217607 0,14711245 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,1217607 0,14703973 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,1217607 0,14696709 ! vitamin transport GO:0051180 31 19 0,000 0,1217607 0,14689451 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,1217607 0,146822 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,1217607 0,14674957 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,1217607 0,14667721 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,1217607 0,14660492 ! cilium assembly GO:0042384 38 19 0,000 0,1217607 0,1465327 ! protein localization in nucleus GO:0034504 192 89 1,000 0,12325119 0,1482534 ! response to inorganic substance GO:0010035 173 90 1,000 0,12551291 0,15089963 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,12774335 0,15350566 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,12774335 0,15343019 ! positive regulation of ossification GO:0045778 50 20 0,000 0,12774335 0,1533548 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,12774335 0,15327948 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,12774335 0,15320423 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,12774335 0,15312905 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,12774335 0,15305395 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,12774335 0,15297893 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,12774335 0,15290397 ! bile acid metabolic process GO:0008206 34 20 0,000 0,12774335 0,1528291 ! retinoid metabolic process GO:0001523 34 20 0,000 0,12774335 0,15275429 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,12774335 0,15267956 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,12774335 0,1526049 ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,12774335 0,15253031 GO:0030968|endoplasmic reticulum unfolded protein response, ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,12774335 0,1524558 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,12774335 0,15238135 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,12774335 0,15230699 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,12774335 0,15223269 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,12774335 0,15215847 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,12774335 0,15208431 ! cell-cell junction organization GO:0045216 43 20 0,000 0,12774335 0,15201024 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,12774335 0,15193623 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,12774335 0,15186229 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,12774335 0,15178843 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,12774335 0,15171464 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,12774335 0,15164092 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,12774335 0,15156727 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,12774335 0,1514937 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,1323567 0,15688861 GO:0010498|proteasomal protein catabolic process, ! vitamin metabolic process GO:0006766 153 93 1,000 0,1323567 0,15681252 ! regulation of cell killing GO:0031341 46 21 0,000 0,13368542 0,15830998 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,13368542 0,15823328 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,13368542 0,15815665 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,13368542 0,1580801 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,13368542 0,15800362 ! plasma membrane fusion GO:0045026 33 21 0,000 0,13368542 0,15792722 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,13368542 0,15785089 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,13368542 0,15777463 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,13368542 0,15769845 ! diencephalon development GO:0021536 36 21 0,000 0,13368542 0,15762234 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,13368542 0,15754631 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,13368542 0,15747034 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,13368542 0,15739445 ! collagen catabolic process GO:0030574 29 21 0,000 0,13368542 0,15731864 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,13368542 0,15724289 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,13368542 0,15716722 ! actin filament-based movement GO:0030048 47 21 0,000 0,13368542 0,15709163 ! phospholipid biosynthetic process GO:0008654 188 95 1,000 0,13696574 0,16086889 ! response to protein stimulus GO:0051789 158 96 1,000 0,13928352 0,16351256 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,13958718 0,16379034 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,13958718 0,16371171 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,13958718 0,16363315 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,13958718 0,16355467 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,13958718 0,16347626 ! microtubule-based transport GO:0010970 59 22 0,000 0,13958718 0,16339793 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,13958718 0,16331968 ! vacuolar transport GO:0007034 41 22 0,000 0,13958718 0,1632415 ! central nervous system neuron development GO:0021954 47 22 0,000 0,13958718 0,16316339 ! fucose metabolic process GO:0006004 44 22 0,000 0,13958718 0,16308536 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,13958718 0,1630074 ! stem cell differentiation GO:0048863 57 22 0,000 0,13958718 0,16292952 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,13958718 0,16285171 ! cytolysis GO:0019835 27 22 0,000 0,13958718 0,16277398 ! vasodilation GO:0042311 40 22 0,000 0,13958718 0,16269632 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,13958718 0,16261873 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,13958718 0,16254122 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,13958718 0,16246378 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,13958718 0,16238642 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,13958718 0,16230913 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,13958718 0,16223191 ! sarcomere organization GO:0045214 32 22 0,000 0,13958718 0,16215477 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,13958718 0,1620777 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,13958718 0,1620007 ! protein stabilization GO:0050821 41 22 0,000 0,13958718 0,16192378 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,1454489 0,16864341 ! gluconeogenesis GO:0006094 38 23 0,000 0,1454489 0,16856341 ! glycerol metabolic process GO:0006071 40 23 0,000 0,1454489 0,16848348 ! viral genome replication GO:0019079 44 23 0,000 0,1454489 0,16840363 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,1454489 0,16832385 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,1454489 0,16824416 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,1454489 0,16816453 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,1454489 0,16808498 ! peroxisome organization GO:0007031 43 23 0,000 0,1454489 0,16800551 ! lysosome organization GO:0007040 47 23 0,000 0,1454489 0,16792611 ! vesicle targeting GO:0006903 49 23 0,000 0,1454489 0,16784679 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,1454489 0,16776754 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,1454489 0,16768837 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,1454489 0,16760927 ! DNA modification GO:0006304 36 23 0,000 0,1454489 0,16753025 ! fatty acid transport GO:0015908 47 23 0,000 0,1454489 0,1674513 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,1454489 0,16737242 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,1454489 0,16729362 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,1454489 0,1672149 ! cell-cell recognition GO:0009988 28 23 0,000 0,1454489 0,16713625 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,1454489 0,16705767 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,1454489 0,16697916 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,1454489 0,16690073 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,15127084 0,17349985 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,15127084 0,17341843 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,15127084 0,17333709 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,15127084 0,17325582 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,15127084 0,17317464 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,15127084 0,17309352 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,15127084 0,17301249 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,15127084 0,17293153 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,15127084 0,17285064 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,15127084 0,17276983 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,15127084 0,1726891 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,15127084 0,17260844 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,15127084 0,17252786 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,15127084 0,17244735 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,15127084 0,17236692 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,15127084 0,17228656 ! platelet activation GO:0030168 41 24 0,000 0,15127084 0,17220628 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,15127084 0,17212607 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,15127084 0,17204594 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,15127084 0,17196588 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,15127084 0,17188589 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,15127084 0,17180598 ! regulation of amine transport GO:0051952 41 24 0,000 0,15127084 0,17172615 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,15705329 0,1782077 ! leukocyte adhesion GO:0007159 55 25 0,000 0,15705329 0,17812497 ! phototransduction GO:0007602 37 25 0,000 0,15705329 0,17804231 ! keratinization GO:0031424 37 25 0,000 0,15705329 0,17795973 ! vacuole organization GO:0007033 49 25 0,000 0,15705329 0,17787723 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,15705329 0,1777948 ! receptor metabolic process GO:0043112 53 25 0,000 0,15705329 0,17771245 ! chromosome condensation GO:0030261 48 25 0,000 0,15705329 0,17763018 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,15705329 0,17754798 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,15705329 0,17746586 ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,15705329 0,17738381 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,15705329 0,17730184 ! initiation of viral infection GO:0019059 60 26 0,000 0,1627965 0,18370062 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,1627965 0,18361581 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,1627965 0,18353108 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,1627965 0,18344643 GO:0051297|centrosome organization, ! digestive system process GO:0022600 49 26 0,000 0,1627965 0,18336185 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,1627965 0,18327735 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,1627965 0,18319293 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,1627965 0,18310859 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,1627965 0,18302432 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,1627965 0,18294013 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! response to estradiol stimulus GO:0032355 43 26 0,000 0,1627965 0,18285602 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,1627965 0,18277199 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,1627965 0,18268803 ! blastocyst development GO:0001824 50 26 0,000 0,1627965 0,18260416 ! telomere organization GO:0032200 46 26 0,000 0,1627965 0,18252035 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,1627965 0,18243663 ! alditol metabolic process GO:0019400 44 26 0,000 0,1627965 0,18235298 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,1627965 0,18226941 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,16850074 0,18856954 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,16850074 0,1884832 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,16850074 0,18839694 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,16850074 0,18831076 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,16850074 0,18822465 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,16850074 0,18813863 ! iron ion transport GO:0006826 65 27 0,000 0,16850074 0,18805268 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,16850074 0,18796681 ! superoxide metabolic process GO:0006801 41 27 0,000 0,16850074 0,18788102 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,16850074 0,18779531 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,16850074 0,18770967 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,16850074 0,18762412 ! neuron fate commitment GO:0048663 52 28 0,000 0,17416628 0,19384429 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,17416628 0,19375602 ! vesicle docking GO:0048278 55 28 0,000 0,17416628 0,19366783 ! circadian rhythm GO:0007623 56 28 0,000 0,17416628 0,19357972 ! fat cell differentiation GO:0045444 57 28 0,000 0,17416628 0,19349169 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,17416628 0,19340373 ! sperm motility GO:0030317 37 28 0,000 0,17416628 0,19331586 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,17416628 0,19322807 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,17416628 0,19314036 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,17416628 0,19305273 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,17416628 0,19296518 ! glutathione metabolic process GO:0006749 42 28 0,000 0,17416628 0,1928777 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,17416628 0,19279031 ! lipid oxidation GO:0034440 48 28 0,000 0,17416628 0,192703 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,17416628 0,19261576 ! translational initiation GO:0006413 66 29 0,000 0,17979337 0,19874896 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,17979337 0,19865907 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,17979337 0,19856926 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,17979337 0,19847953 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,17979337 0,19838988 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,17979337 0,19830032 ! synaptogenesis GO:0007416 46 29 0,000 0,17979337 0,19821083 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,17979337 0,19812142 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,17979337 0,1980321 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,18538227 0,20409594 ! phenol metabolic process GO:0018958 56 30 0,000 0,18538227 0,20400401 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,18538227 0,20391216 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,18538227 0,20382039 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,18538227 0,2037287 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,18538227 0,20363709 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,18538227 0,20354557 ! acute-phase response GO:0006953 50 30 0,000 0,18538227 0,20345413 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,18538227 0,20336277 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,18538227 0,2032715 ! myofibril assembly GO:0030239 50 30 0,000 0,18538227 0,2031803 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,18538227 0,20308919 GO:0002764|immune response-regulating signal transduction, ! cell fate determination GO:0001709 64 30 0,000 0,18538227 0,20299816 ! phospholipid transport GO:0015914 65 30 0,000 0,18538227 0,20290721 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,18538227 0,20281634 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,18538227 0,20272556 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,18538227 0,20263485 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,19093325 0,2086091 ! zinc ion transport GO:0006829 54 31 0,000 0,19093325 0,20851584 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,19093325 0,20842267 ! regulation of innate immune response GO:0045088 57 31 0,000 0,19093325 0,20832958 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,19093325 0,20823658 ! detection of light stimulus GO:0009583 44 31 0,000 0,19093325 0,20814366 ! natural killer cell activation GO:0030101 50 31 0,000 0,19093325 0,20805082 ! cofactor catabolic process GO:0051187 54 31 0,000 0,19093325 0,20795807 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,19093325 0,20786539 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,19093325 0,2077728 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,19644656 0,21367718 ! collagen metabolic process GO:0032963 49 32 0,000 0,19644656 0,21358209 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,19644656 0,21348708 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,19644656 0,21339215 ! muscle cell development GO:0055001 52 32 0,000 0,19644656 0,21329731 ! mesoderm formation GO:0001707 73 32 0,000 0,19644656 0,21320256 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,19644656 0,21310788 ! BMP signaling pathway GO:0030509 71 32 0,000 0,19644656 0,2130133 ! gene silencing GO:0016458 71 32 0,000 0,19644656 0,21291879 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,20192246 0,21875679 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,20192246 0,21865982 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,20192246 0,21856294 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,20192246 0,21846615 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,20192246 0,21836944 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,20192246 0,21827282 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,20192246 0,21817628 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,20192246 0,21807982 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,20192246 0,21798346 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,20736119 0,22375591 ! cholesterol transport GO:0030301 62 34 0,000 0,20736119 0,22365712 ! spliceosome assembly GO:0000245 75 34 0,000 0,20736119 0,22355842 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,20736119 0,22345981 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,20736119 0,22336128 ! formation of primary germ layer GO:0001704 76 34 0,000 0,20736119 0,22326284 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,20736119 0,22316449 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,21276301 0,22887716 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,21276301 0,22877642 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,21276301 0,22867577 ! membrane docking GO:0022406 69 35 0,000 0,21276301 0,22857521 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,21276301 0,22847474 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,21276301 0,22837435 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,21276301 0,22827406 ! ceramide metabolic process GO:0006672 72 35 0,000 0,21276301 0,22817385 ! sterol transport GO:0015918 63 35 0,000 0,21276301 0,22807373 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,21276301 0,2279737 ! placenta development GO:0001890 53 35 0,000 0,21276301 0,22787375 ! vesicle localization GO:0051648 70 35 0,000 0,21276301 0,22777389 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,21812816 0,23341529 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,21812816 0,23331309 ! protein targeting to membrane GO:0006612 75 36 0,000 0,21812816 0,23321099 ! aerobic respiration GO:0009060 56 36 0,000 0,21812816 0,23310897 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,21812816 0,23300704 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,22345691 0,23859494 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,22345691 0,2384907 ! actomyosin structure organization GO:0031032 68 37 0,000 0,22345691 0,23838656 ! tissue remodeling GO:0048771 78 37 0,000 0,22345691 0,23828251 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,22345691 0,23817854 ! organic anion transport GO:0015711 82 38 0,000 0,22874948 0,24371347 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,22874948 0,24360723 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,22874948 0,24350108 ! glycogen metabolic process GO:0005977 63 38 0,000 0,22874948 0,24339503 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,23400613 0,24887983 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,23400613 0,24877153 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,23400613 0,24866332 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,23400613 0,24855521 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,23400613 0,24844719 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,23400613 0,24833926 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,23400613 0,24823143 ! glucan metabolic process GO:0044042 64 39 0,000 0,23400613 0,24812369 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,2392271 0,25354959 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,2392271 0,25343964 ! lipid homeostasis GO:0055088 75 40 0,000 0,2392271 0,25332978 ! RNA export from nucleus GO:0006405 61 41 0,000 0,24441263 0,25870886 ! mRNA catabolic process GO:0006402 79 41 0,000 0,24441263 0,25859682 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,24441263 0,25848487 ! feeding behavior GO:0007631 69 41 0,000 0,24441263 0,25837302 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,24441263 0,25826127 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,24441263 0,25814961 ! RNA modification GO:0009451 64 41 0,000 0,24441263 0,25803805 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,24956296 0,26336169 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,24956296 0,26324797 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,24956296 0,26313436 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,24956296 0,26302084 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,25467833 0,26829631 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,25467833 0,26818067 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,25467833 0,26806512 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,25467833 0,26794968 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,25467833 0,26783433 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,25467833 0,26771908 ! ion transmembrane transport GO:0034220 79 43 0,000 0,25467833 0,26760394 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,25467833 0,26748889 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,25975897 0,27270785 ! striated muscle contraction GO:0006941 85 44 0,000 0,25975897 0,2725907 ! phagocytosis GO:0006909 105 44 0,000 0,25975897 0,27247366 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,25975897 0,27235672 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,26480512 0,27752849 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,26480512 0,27740948 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,26480512 0,27729057 ! polyol metabolic process GO:0019751 77 45 0,000 0,26480512 0,27717177 ! maintenance of location in cell GO:0051651 101 45 0,000 0,26480512 0,27705306 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,26981701 0,28217592 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,26981701 0,28205518 ! glycolysis GO:0006096 71 46 0,000 0,26981701 0,28193454 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,26981701 0,281814 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,26981701 0,28169357 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,26981701 0,28157324 ! endosome transport GO:0016197 127 48 0,000 0,27973894 0,29180284 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,27973894 0,29167829 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,27973894 0,29155386 ! response to calcium ion GO:0051592 94 49 0,000 0,28464945 0,29654524 ! protein homooligomerization GO:0051260 84 49 0,000 0,28464945 0,29641884 ! regulation of ion transport GO:0043269 86 50 0,000 0,28952661 0,3013692 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,28952661 0,30124084 ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,28952661 0,3011126 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,28952661 0,30098447 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,29437065 0,30589005 ! Notch signaling pathway GO:0007219 111 52 0,000 0,29918181 0,31075729 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,29918181 0,31062523 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,29918181 0,31049327 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,29918181 0,31036143 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,29918181 0,31022969 ! amino acid activation GO:0043038 98 52 0,000 0,29918181 0,31009807 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,30396029 0,3149173 ! inner ear development GO:0048839 89 53 0,000 0,30396029 0,31478381 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,30396029 0,31465042 ! regulation of translational initiation GO:0006446 87 54 0,000 0,30870633 0,31942802 ! membrane fusion GO:0006944 122 54 0,000 0,30870633 0,31929279 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,30870633 0,31915767 ! regulation of cell shape GO:0008360 142 54 0,000 0,30870633 0,31902266 ! RNA catabolic process GO:0006401 103 55 0,000 0,31342014 0,32375704 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,31342014 0,3236202 ! cell recognition GO:0008037 98 55 0,000 0,31342014 0,32348348 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,31342014 0,32334688 ! glucose catabolic process GO:0006007 88 56 0,000 0,31810194 0,32803843 ! chloride transport GO:0006821 102 57 0,000 0,32275194 0,33269325 ! regulation of actin filament length GO:0030832 118 58 0,000 0,32737037 0,3373116 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,32737037 0,33716939 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,32737037 0,33702731 ! gastrulation GO:0007369 122 58 0,000 0,32737037 0,33688534 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,32737037 0,3367435 ! maintenance of location GO:0051235 124 58 0,000 0,32737037 0,33660177 ! nuclear export GO:0051168 110 59 0,000 0,33195742 0,34117458 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,33651333 0,34571155 ! regulation of endocytosis GO:0030100 104 60 0,000 0,33651333 0,34556623 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,33651333 0,34542104 ! regulation of cellular component size GO:0032535 125 61 0,000 0,34103829 0,34991875 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,34103829 0,34977185 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,34103829 0,34962507 ! proton transport GO:0015992 117 61 0,000 0,34103829 0,34947842 ! tRNA processing GO:0008033 102 62 0,000 0,34553252 0,35393541 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,34999623 0,35835741 ! mesoderm development GO:0007498 128 63 0,000 0,34999623 0,35820728 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,34999623 0,35805728 ! hydrogen transport GO:0006818 121 64 0,000 0,35442961 0,36244099 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,35883288 0,36679026 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,36320624 0,37110533 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,36754989 0,37538645 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,36754989 0,37522958 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,37186404 0,37947529 ! hexose catabolic process GO:0019320 113 68 0,000 0,37186404 0,37931684 ! cell projection assembly GO:0030031 138 68 0,000 0,37186404 0,37915853 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,37614888 0,38336742 ! single fertilization GO:0007338 83 69 0,000 0,37614888 0,38320755 ! cell redox homeostasis GO:0045454 114 70 0,000 0,3804046 0,3873816 ! activation of immune response GO:0002253 120 70 0,000 0,3804046 0,38722019 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,38463142 0,39135967 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,38463142 0,39119674 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,38882952 0,39530192 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,38882952 0,39513749 ! regulation of immune effector process GO:0002697 156 73 0,000 0,3929991 0,39920865 ! acute inflammatory response GO:0002526 118 74 0,000 0,39714035 0,40324766 ! amino acid transport GO:0006865 148 74 0,000 0,39714035 0,40308013 ! transition metal ion transport GO:0000041 143 75 0,000 0,40125346 0,40708563 ! amine catabolic process GO:0009310 136 77 0,000 0,40939603 0,41517413 ! neurotransmitter transport GO:0006836 142 77 0,000 0,40939603 0,41500186 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,40939603 0,41482973 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,40939603 0,41465775 ! antigen processing and presentation GO:0019882 117 78 0,000 0,41342586 0,41856584 ! fertilization GO:0009566 99 78 0,000 0,41342586 0,41839245 ! muscle cell differentiation GO:0042692 178 81 0,000 0,4253518 0,43028342 ! exocytosis GO:0006887 153 83 0,000 0,43316797 0,43800884 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,43316797 0,43782762 ! inorganic anion transport GO:0015698 156 83 0,000 0,43316797 0,43764655 ! digestion GO:0007586 130 84 0,000 0,43703626 0,44137229 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,44087825 0,44506842 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,44848409 0,45255953 ! alcohol catabolic process GO:0046164 142 87 0,000 0,44848409 0,45237268 ! nucleosome assembly GO:0006334 126 87 0,000 0,44848409 0,45218598 ! cellular respiration GO:0045333 143 88 0,000 0,45224828 0,45579313 ! amine biosynthetic process GO:0009309 146 88 0,000 0,45224828 0,45560517 ! sensory perception of smell GO:0007608 117 88 0,000 0,45224828 0,45541737 ! chromatin assembly GO:0031497 128 88 0,000 0,45224828 0,45522972 ! cellular defense response GO:0006968 123 89 0,000 0,45598688 0,45880393 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,45970007 0,46234964 ! response to unfolded protein GO:0006986 139 90 0,000 0,45970007 0,46215937 ! defense response to bacterium GO:0042742 112 91 0,000 0,46338802 0,46567541 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,4670509 0,46916338 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,47068888 0,47262348 ! amine transport GO:0015837 181 93 0,000 0,47068888 0,47242931 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,47430213 0,47586041 ! sterol metabolic process GO:0016125 166 94 0,000 0,47430213 0,47566507 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,47430213 0,47546988 ! nucleosome organization GO:0034728 143 95 0,000 0,47789082 0,4788709 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,47789082 0,47867456 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,47789082 0,47847839 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,48499516 0,48539253 ! mRNA transport GO:0051028 185 100 0,000 0,49547156 0,49567446 ! positive regulation of immune response GO:0050778 175 100 0,000 0,49547156 0,49547156