pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6429-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! apoptotic mitochondrial changes GO:0008637 29 18 4,000 7,224E-08 1,662E-04 ! induction of positive chemotaxis GO:0050930 14 8 3,000 1,019E-07 1,172E-04 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 2,729E-07 2,092E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 4,000 2,767E-07 1,591E-04 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 2,767E-07 1,273E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 4,325E-07 1,658E-04 GO:0045936|negative regulation of phosphate metabolic process, ! peptidyl-tyrosine modification GO:0018212 37 25 4,000 4,325E-07 1,421E-04 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 4,733E-07 1,361E-04 GO:0050927|positive regulation of positive chemotaxis, ! interphase of mitotic cell cycle GO:0051329 156 86 6,000 1,15E-06 2,938E-04 ! interphase GO:0051325 159 88 6,000 1,344E-06 3,092E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 1,415E-06 2,959E-04 ! regulation of sensory perception GO:0051931 6 5 2,000 2,402E-06 4,604E-04 GO:0051930|regulation of sensory perception of pain, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 4,000 4,969E-06 8,792E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 4,969E-06 8,164E-04 ! cell structure disassembly during apoptosis GO:0006921 24 19 3,000 5,347E-06 8,199E-04 ! microtubule-based transport GO:0010970 37 20 3,000 6,652E-06 9,562E-04 ! positive regulation of locomotion GO:0040017 35 20 3,000 6,652E-06 9E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 3,000 8,177E-06 1,045E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 2,000 8,33E-06 1,008E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 8,33E-06 9,579E-04 ! regulation of behavior GO:0050795 38 22 3,000 9,946E-06 1,089E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 1,327E-05 1,387E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 1,327E-05 1,327E-03 ! cell cycle arrest GO:0007050 150 86 5,000 1,69E-05 1,62E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 1,981E-05 1,822E-03 ! thymus development GO:0048538 15 9 2,000 1,981E-05 1,752E-03 ! spleen development GO:0048536 15 9 2,000 1,981E-05 1,687E-03 ! negative regulation of BMP signaling pathway GO:0030514 13 9 2,000 1,981E-05 1,627E-03 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 2,644E-05 2,097E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 2,905E-05 2,227E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 2,905E-05 2,155E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 3,163E-05 2,273E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 3,855E-05 2,687E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 3,855E-05 2,608E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 3,855E-05 2,533E-03 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of transferase activity GO:0051348 105 61 4,000 4,045E-05 2,584E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 4,378E-05 2,722E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 5,107E-05 3,091E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 4,000 5,107E-05 3,012E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 6,621E-05 3,807E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 7,868E-05 4,414E-03 ! learning GO:0007612 67 37 3,000 8,351E-05 4,573E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 8,389E-05 4,487E-03 ! startle response GO:0001964 21 14 2,000 8,389E-05 4,385E-03 ! epidermis morphogenesis GO:0048730 29 14 2,000 8,389E-05 4,288E-03 ! axon cargo transport GO:0008088 27 14 2,000 8,389E-05 4,194E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 9,006E-05 4,407E-03 GO:0045937|positive regulation of phosphate metabolic process, ! pigmentation GO:0043473 74 38 3,000 9,288E-05 4,451E-03 ! mitochondrion organization GO:0007005 104 73 4,000 9,62E-05 4,515E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,044E-04 4,801E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,044E-04 4,707E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 1,044E-04 4,617E-03 ! regulation of BMP signaling pathway GO:0030510 21 15 2,000 1,044E-04 4,53E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,044E-04 4,446E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of growth GO:0045926 123 75 4,000 1,094E-04 4,577E-03 ! response to nutrient GO:0007584 104 75 4,000 1,094E-04 4,495E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 1,139E-04 4,596E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,279E-04 5,071E-03 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 2,000 1,279E-04 4,985E-03 ! positive regulation of protein modification process GO:0031401 107 78 4,000 1,319E-04 5,055E-03 ! cellular component disassembly GO:0022411 64 42 3,000 1,381E-04 5,209E-03 ! activation of caspase activity GO:0006919 65 43 3,000 1,516E-04 5,623E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 1,546E-04 5,643E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 1,546E-04 5,555E-03 ! negative regulation of cell migration GO:0030336 92 44 3,000 1,659E-04 5,871E-03 ! response to retinoic acid GO:0032526 25 18 2,000 1,846E-04 6,434E-03 ! regulation of glucose import GO:0046324 21 18 2,000 1,846E-04 6,338E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 1,846E-04 6,245E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 1,979E-04 6,596E-03 ! response to alkaloid GO:0043279 32 19 2,000 2,183E-04 7,171E-03 ! response to vitamin A GO:0033189 26 19 2,000 2,183E-04 7,07E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 2,183E-04 6,972E-03 ! positive regulation of caspase activity GO:0043280 72 48 3,000 2,333E-04 7,35E-03 GO:0010952|positive regulation of peptidase activity, ! regulation of angiogenesis GO:0045765 94 49 3,000 2,528E-04 7,857E-03 ! response to vitamin GO:0033273 29 20 2,000 2,556E-04 7,838E-03 ! response to ethanol GO:0045471 37 20 2,000 2,556E-04 7,735E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 2,556E-04 7,635E-03 ! positive regulation of growth GO:0045927 67 50 3,000 2,735E-04 8,064E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 2,953E-04 8,597E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 2,953E-04 8,49E-03 ! negative regulation of cell motion GO:0051271 104 51 3,000 2,953E-04 8,385E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 2,968E-04 8,326E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 2,968E-04 8,225E-03 ! glutamate signaling pathway GO:0007215 34 22 2,000 3,421E-04 9,368E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 3,421E-04 9,257E-03 GO:0010810|regulation of cell-substrate adhesion, ! protein tetramerization GO:0051262 39 22 2,000 3,421E-04 9,15E-03 ! regulation of bone remodeling GO:0046850 90 53 3,000 3,427E-04 9,06E-03 ! regulation of tissue remodeling GO:0034103 91 54 3,000 3,683E-04 9,627E-03 ! sleep GO:0030431 11 5 1,000 3,875E-04 0,01001439 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,875E-04 9,903E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 3,875E-04 9,794E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 3,875E-04 9,688E-03 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 1,000 3,875E-04 9,584E-03 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 1,000 3,875E-04 9,482E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 3,875E-04 9,382E-03 ! parathyroid gland development GO:0060017 8 5 1,000 3,875E-04 9,284E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 3,875E-04 9,188E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 3,875E-04 9,095E-03 ! valine metabolic process GO:0006573 8 5 1,000 3,875E-04 9,003E-03 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 3,875E-04 8,913E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 3,875E-04 8,825E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 3,875E-04 8,738E-03 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 3,875E-04 8,653E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 3,875E-04 8,57E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 3,875E-04 8,488E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 3,875E-04 8,408E-03 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 3,916E-04 8,419E-03 ! calcium ion transport GO:0006816 167 99 4,000 4,025E-04 8,571E-03 ! extracellular structure organization GO:0043062 156 99 4,000 4,025E-04 8,492E-03 ! divalent metal ion transport GO:0070838 171 100 4,000 4,215E-04 8,814E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 4,237E-04 8,779E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 4,456E-04 9,15E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 4,456E-04 9,069E-03 ! fat cell differentiation GO:0045444 37 24 2,000 4,456E-04 8,989E-03 ! regulation of chromosome organization GO:0033044 35 25 2,000 5,04E-04 0,01007991 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 5,04E-04 9,993E-03 ! regulation of homeostatic process GO:0032844 105 60 3,000 5,518E-04 0,01084638 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 5,671E-04 0,01105429 ! negative regulation of protein modification process GO:0031400 50 26 2,000 5,671E-04 0,0109614 ! mRNA stabilization GO:0048255 15 6 1,000 5,789E-04 0,01109519 GO:0043489|RNA stabilization, ! pigment granule organization GO:0048753 11 6 1,000 5,789E-04 0,01100349 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 5,789E-04 0,0109133 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 5,789E-04 0,01082457 ! male sex determination GO:0030238 9 6 1,000 5,789E-04 0,01073728 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 5,789E-04 0,01065138 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 5,789E-04 0,01056684 ! negative regulation of B cell activation GO:0050869 9 6 1,000 5,789E-04 0,01048364 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 5,789E-04 0,01040174 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 6,351E-04 0,01132373 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 6,643E-04 0,01175322 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 7,081E-04 0,01243198 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 7,081E-04 0,0123378 ! regulation of caspase activity GO:0043281 97 65 3,000 7,478E-04 0,01293235 ! protein oligomerization GO:0051259 100 65 3,000 7,478E-04 0,01283584 ! response to hydrogen peroxide GO:0042542 42 29 2,000 7,862E-04 0,01339421 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 8,071E-04 0,01364947 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 8,071E-04 0,01354984 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 8,071E-04 0,01345165 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 8,071E-04 0,01335488 ! T-helper 1 type immune response GO:0042088 11 7 1,000 8,071E-04 0,01325949 ! regulation of pigmentation during development GO:0048070 15 7 1,000 8,071E-04 0,01316545 ! organ growth GO:0035265 11 7 1,000 8,071E-04 0,01307273 ! behavioral fear response GO:0001662 13 7 1,000 8,071E-04 0,01298131 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 8,071E-04 0,01289117 ! response to UV-B GO:0010224 11 7 1,000 8,071E-04 0,01280226 ! B cell lineage commitment GO:0002326 17 7 1,000 8,071E-04 0,01271457 ! T cell lineage commitment GO:0002360 12 7 1,000 8,071E-04 0,01262808 ! peptidyl-threonine modification GO:0018210 18 7 1,000 8,071E-04 0,01254276 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 8,071E-04 0,01245858 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 1,000 8,071E-04 0,01237552 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 8,385E-04 0,01277193 ! spindle organization GO:0007051 37 30 2,000 8,696E-04 0,01315771 ! negative regulation of cell activation GO:0050866 44 30 2,000 8,696E-04 0,01307171 ! learning or memory GO:0007611 123 68 3,000 8,866E-04 0,01324193 ! response to drug GO:0042493 108 69 3,000 9,367E-04 0,01389908 ! response to mechanical stimulus GO:0009612 43 31 2,000 9,583E-04 0,01412924 ! leukocyte chemotaxis GO:0030595 43 31 2,000 9,583E-04 0,01403925 GO:0060326|cell chemotaxis, ! phosphoinositide-mediated signaling GO:0048015 109 71 3,000 1,043E-03 0,01517817 ! regulation of synaptic plasticity GO:0048167 52 32 2,000 1,053E-03 0,01522701 ! regulation of protein stability GO:0031647 48 32 2,000 1,053E-03 0,01513184 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,072E-03 0,01531014 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,072E-03 0,01521564 ! succinate metabolic process GO:0006105 14 8 1,000 1,072E-03 0,01512229 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,072E-03 0,01503008 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,072E-03 0,01493899 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,072E-03 0,014849 ! melanin metabolic process GO:0006582 12 8 1,000 1,072E-03 0,01476008 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,072E-03 0,01467222 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,072E-03 0,0145854 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,072E-03 0,01449961 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,072E-03 0,01441481 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,072E-03 0,01433101 ! S phase GO:0051320 8 8 1,000 1,072E-03 0,01424817 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,072E-03 0,01416628 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,072E-03 0,01408533 ! regulation of embryonic development GO:0045995 16 8 1,000 1,072E-03 0,0140053 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,072E-03 0,01392618 ! regulation of peptidase activity GO:0052547 106 72 3,000 1,099E-03 0,01419682 ! carbohydrate homeostasis GO:0033500 39 33 2,000 1,153E-03 0,01481046 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 2,000 1,153E-03 0,01472818 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,153E-03 0,01464681 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 1,217E-03 0,0153805 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 1,258E-03 0,01581631 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,258E-03 0,01573035 ! response to inorganic substance GO:0010035 115 75 3,000 1,279E-03 0,01590688 ! regulation of developmental growth GO:0048638 13 9 1,000 1,372E-03 0,01696873 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,372E-03 0,01687798 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 1,372E-03 0,01678821 ! regulation of glycolysis GO:0006110 15 9 1,000 1,372E-03 0,01669938 ! lung alveolus development GO:0048286 17 9 1,000 1,372E-03 0,01661149 ! T cell selection GO:0045058 18 9 1,000 1,372E-03 0,01652452 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,372E-03 0,01643845 GO:0006600|creatine metabolic process, ! indolalkylamine metabolic process GO:0006586 14 9 1,000 1,372E-03 0,01635328 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! motor axon guidance GO:0008045 14 9 1,000 1,372E-03 0,01626899 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,372E-03 0,01618555 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,372E-03 0,01610298 ! response to amine stimulus GO:0014075 13 9 1,000 1,372E-03 0,01602123 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,372E-03 0,01594032 ! oocyte differentiation GO:0009994 12 9 1,000 1,372E-03 0,01586022 GO:0048599|oocyte development, ! response to nicotine GO:0035094 16 9 1,000 1,372E-03 0,01578092 ! gland development GO:0048732 148 77 3,000 1,411E-03 0,01614489 ! response to reactive oxygen species GO:0000302 55 36 2,000 1,488E-03 0,01694136 ! regulation of neurological system process GO:0031644 122 81 3,000 1,702E-03 0,01927923 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,708E-03 0,01925996 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 1,708E-03 0,01916601 ! hair follicle morphogenesis GO:0031069 17 10 1,000 1,708E-03 0,01907297 ! blood vessel remodeling GO:0001974 21 10 1,000 1,708E-03 0,01898083 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 1,708E-03 0,01888958 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,708E-03 0,0187992 ! B cell proliferation GO:0042100 14 10 1,000 1,708E-03 0,01870968 ! fear response GO:0042596 16 10 1,000 1,708E-03 0,01862101 ! negative regulation of ossification GO:0030279 19 10 1,000 1,708E-03 0,01853317 ! regulation of bone resorption GO:0045124 24 10 1,000 1,708E-03 0,01844616 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,708E-03 0,01835997 ! response to dsRNA GO:0043331 18 10 1,000 1,708E-03 0,01827457 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,708E-03 0,01818997 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,708E-03 0,01810614 GO:0043470|regulation of carbohydrate catabolic process, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 1,708E-03 0,01802309 ! regulation of T cell proliferation GO:0042129 58 38 2,000 1,742E-03 0,01829501 ! mesenchymal cell development GO:0014031 64 38 2,000 1,742E-03 0,01821185 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of cell adhesion GO:0030155 159 83 3,000 1,861E-03 0,01937286 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 2,000 1,879E-03 0,01946284 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 1,879E-03 0,01937556 ! synapse organization GO:0050808 55 39 2,000 1,879E-03 0,01928907 ! regulation of membrane potential GO:0042391 128 85 3,000 2,031E-03 0,02076624 ! rRNA transcription GO:0009303 17 11 1,000 2,079E-03 0,02116127 ! virus-host interaction GO:0019048 17 11 1,000 2,079E-03 0,02106805 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,079E-03 0,02097564 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 2,079E-03 0,02088405 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 2,079E-03 0,02079325 ! focal adhesion formation GO:0048041 24 11 1,000 2,079E-03 0,02070323 ! protein homotetramerization GO:0051289 18 11 1,000 2,079E-03 0,02061399 ! T cell homeostasis GO:0043029 20 11 1,000 2,079E-03 0,02052552 ! regulation of leukocyte migration GO:0002685 24 11 1,000 2,079E-03 0,02043781 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,079E-03 0,02035084 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! actin filament polymerization GO:0030041 17 11 1,000 2,079E-03 0,0202646 ! regulation of T cell differentiation GO:0045580 59 41 2,000 2,171E-03 0,02107228 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 2,485E-03 0,02401428 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 2,485E-03 0,0239138 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 2,485E-03 0,02381416 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! gland morphogenesis GO:0022612 23 12 1,000 2,485E-03 0,02371535 ! response to gamma radiation GO:0010332 20 12 1,000 2,485E-03 0,02361735 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,485E-03 0,02352016 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,485E-03 0,02342376 ! leukocyte migration GO:0050900 60 43 2,000 2,491E-03 0,02338468 ! neuromuscular process GO:0050905 79 43 2,000 2,491E-03 0,02328962 ! response to insulin stimulus GO:0032868 63 43 2,000 2,491E-03 0,02319533 ! glycolysis GO:0006096 53 44 2,000 2,661E-03 0,02467958 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 2,661E-03 0,02458046 ! regulation of inflammatory response GO:0050727 60 44 2,000 2,661E-03 0,02448214 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,661E-03 0,0243846 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,838E-03 0,02590453 ! positive regulation of defense response GO:0031349 59 45 2,000 2,838E-03 0,02580214 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 2,838E-03 0,02570055 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 2,925E-03 0,02637989 ! cellular pigmentation GO:0033059 24 13 1,000 2,925E-03 0,02627684 ! regulation of RNA stability GO:0043487 28 13 1,000 2,925E-03 0,0261746 ! lymphocyte homeostasis GO:0002260 24 13 1,000 2,925E-03 0,02607315 ! regulation of ossification GO:0030278 71 46 2,000 3,022E-03 0,02684046 ! response to UV GO:0009411 75 46 2,000 3,022E-03 0,02673723 ! regulation of response to external stimulus GO:0032101 139 96 3,000 3,162E-03 0,02786216 ! response to light stimulus GO:0009416 153 96 3,000 3,162E-03 0,02775581 ! negative regulation of immune system process GO:0002683 73 47 2,000 3,214E-03 0,02810631 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 3,214E-03 0,02799985 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 3,398E-03 0,02949382 ! heterophilic cell adhesion GO:0007157 29 14 1,000 3,398E-03 0,02938294 ! response to cAMP GO:0051591 19 14 1,000 3,398E-03 0,02927289 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 3,398E-03 0,02916366 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 3,398E-03 0,02905525 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 3,398E-03 0,02894763 ! muscle maintenance GO:0046716 19 14 1,000 3,398E-03 0,02884082 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 3,398E-03 0,02873478 ! regulation of muscle contraction GO:0006937 69 48 2,000 3,413E-03 0,02875087 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 3,413E-03 0,02864594 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 3,532E-03 0,02953816 ! cartilage development GO:0051216 70 49 2,000 3,619E-03 0,03015564 ! Ras protein signal transduction GO:0007265 162 100 3,000 3,661E-03 0,03040092 ! ear development GO:0043583 72 50 2,000 3,832E-03 0,03170527 ! skeletal muscle fiber development GO:0048741 73 50 2,000 3,832E-03 0,03159163 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 3,832E-03 0,0314788 ! metencephalon development GO:0022037 19 15 1,000 3,905E-03 0,03196216 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 3,905E-03 0,03184882 ! skin development GO:0043588 25 15 1,000 3,905E-03 0,03173628 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 1,000 3,905E-03 0,03162453 ! myoblast differentiation GO:0045445 27 15 1,000 3,905E-03 0,03151357 ! regulation of survival gene product expression GO:0045884 20 15 1,000 3,905E-03 0,03140338 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 3,905E-03 0,03129396 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 3,905E-03 0,0311853 ! biomineral formation GO:0031214 18 15 1,000 3,905E-03 0,0310774 ! dopamine metabolic process GO:0042417 30 15 1,000 3,905E-03 0,03097023 ! defense response to virus GO:0051607 27 15 1,000 3,905E-03 0,03086381 ! muscle fiber development GO:0048747 74 51 2,000 4,053E-03 0,03192635 ! aging GO:0007568 79 52 2,000 4,282E-03 0,03361238 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 4,445E-03 0,03477008 ! cellular response to unfolded protein GO:0034620 19 16 1,000 4,445E-03 0,03465222 GO:0030968|endoplasmic reticulum unfolded protein response, ! fructose metabolic process GO:0006000 20 16 1,000 4,445E-03 0,03453515 ! regulation of protein binding GO:0043393 27 16 1,000 4,445E-03 0,03441887 ! oogenesis GO:0048477 23 16 1,000 4,445E-03 0,03430337 ! G1 phase GO:0051318 27 16 1,000 4,445E-03 0,03418864 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 4,445E-03 0,03407468 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 4,445E-03 0,03396147 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 4,445E-03 0,03384902 ! negative regulation of translation GO:0017148 22 16 1,000 4,445E-03 0,03373731 ! glucose catabolic process GO:0006007 66 54 2,000 4,762E-03 0,03603125 ! DNA catabolic process GO:0006308 67 54 2,000 4,762E-03 0,03591312 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 5,017E-03 0,03770585 ! glycerol metabolic process GO:0006071 20 17 1,000 5,017E-03 0,03758303 ! signal complex assembly GO:0007172 29 17 1,000 5,017E-03 0,03746101 ! memory GO:0007613 25 17 1,000 5,017E-03 0,03733977 ! regulation of viral genome replication GO:0045069 24 17 1,000 5,017E-03 0,03721932 ! cell-substrate junction assembly GO:0007044 39 17 1,000 5,017E-03 0,03709965 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 5,017E-03 0,03698074 ! actin polymerization or depolymerization GO:0008154 31 17 1,000 5,017E-03 0,03686259 ! neuromuscular junction development GO:0007528 23 17 1,000 5,017E-03 0,03674519 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 5,017E-03 0,03662854 ! synaptogenesis GO:0007416 24 17 1,000 5,017E-03 0,03651263 ! peptidyl-serine modification GO:0018209 27 17 1,000 5,017E-03 0,03639744 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 5,274E-03 0,03814664 ! positive regulation of DNA replication GO:0045740 29 18 1,000 5,621E-03 0,040524 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 5,621E-03 0,04039736 ! pancreas development GO:0031016 26 18 1,000 5,621E-03 0,04027151 ! pigmentation during development GO:0048066 31 18 1,000 5,621E-03 0,04014645 ! prostaglandin metabolic process GO:0006693 31 18 1,000 5,621E-03 0,04002216 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 1,000 5,621E-03 0,03989863 ! gut development GO:0048565 26 18 1,000 5,621E-03 0,03977587 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 5,621E-03 0,03965385 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 5,818E-03 0,04092072 ! activation of MAPK activity GO:0000187 84 59 2,000 6,102E-03 0,04278707 ! actin filament organization GO:0007015 95 59 2,000 6,102E-03 0,04265702 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 6,256E-03 0,04360285 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 6,256E-03 0,04347112 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 6,256E-03 0,04334019 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 1,000 6,256E-03 0,04321004 ! regeneration GO:0031099 32 19 1,000 6,256E-03 0,04308067 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 6,256E-03 0,04295207 ! sex determination GO:0007530 29 19 1,000 6,256E-03 0,04282423 ! plasma membrane fusion GO:0045026 23 19 1,000 6,256E-03 0,04269716 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 6,256E-03 0,04257083 ! renal system process GO:0003014 35 19 1,000 6,256E-03 0,04244526 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 6,256E-03 0,04232042 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 6,256E-03 0,04219631 ! regulation of heart contraction GO:0008016 91 60 2,000 6,394E-03 0,04300003 ! cell-matrix adhesion GO:0007160 114 61 2,000 6,694E-03 0,04488851 ! homeostasis of number of cells GO:0048872 84 61 2,000 6,694E-03 0,04475802 ! extracellular matrix organization GO:0030198 103 61 2,000 6,694E-03 0,04462828 ! multicellular organismal response to stress GO:0033555 32 20 1,000 6,923E-03 0,04601848 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 6,923E-03 0,04588587 ! fatty acid beta-oxidation GO:0006635 31 20 1,000 6,923E-03 0,04575401 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 6,923E-03 0,04562291 ! collagen fibril organization GO:0030199 45 20 1,000 6,923E-03 0,04549256 ! alditol metabolic process GO:0019400 24 20 1,000 6,923E-03 0,04536295 ! actin filament-based movement GO:0030048 34 20 1,000 6,923E-03 0,04523408 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 7,32E-03 0,04769253 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 7,62E-03 0,0495101 ! visual behavior GO:0007632 39 21 1,000 7,62E-03 0,04937063 ! ovarian follicle development GO:0001541 30 21 1,000 7,62E-03 0,04923195 ! cell aging GO:0007569 32 21 1,000 7,62E-03 0,04909405 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 7,62E-03 0,04895691 ! regulation of insulin secretion GO:0050796 26 21 1,000 7,62E-03 0,04882054 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 7,62E-03 0,04868493 ! response to cytokine stimulus GO:0034097 47 21 1,000 7,62E-03 0,04855007 ! cell cycle checkpoint GO:0000075 108 64 2,000 7,645E-03 0,04857368 ! hexose catabolic process GO:0019320 82 64 2,000 7,645E-03 0,04843986 ! adaptive immune response GO:0002250 94 64 2,000 7,645E-03 0,04830679 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell-substrate adhesion GO:0031589 121 66 2,000 8,321E-03 0,05243388 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 8,348E-03 0,0524605 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 8,348E-03 0,05231756 ! spliceosomal snRNP biogenesis GO:0000387 28 22 1,000 8,348E-03 0,05217539 ! molting cycle process GO:0022404 40 22 1,000 8,348E-03 0,05203399 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 8,348E-03 0,05189336 ! vasculogenesis GO:0001570 33 22 1,000 8,348E-03 0,05175349 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 8,348E-03 0,05161436 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! ureteric bud development GO:0001657 32 22 1,000 8,348E-03 0,05147599 ! membrane depolarization GO:0051899 35 22 1,000 8,348E-03 0,05133835 ! leukocyte homeostasis GO:0001776 33 22 1,000 8,348E-03 0,05120145 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 9,106E-03 0,05570047 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 9,106E-03 0,05555273 ! myelination GO:0042552 35 23 1,000 9,106E-03 0,05540576 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 9,106E-03 0,05525957 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 9,106E-03 0,05511415 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 9,106E-03 0,05496949 ! regulation of viral reproduction GO:0050792 32 23 1,000 9,106E-03 0,0548256 ! interaction with host GO:0051701 37 23 1,000 9,106E-03 0,05468245 ! lymphocyte proliferation GO:0046651 36 23 1,000 9,106E-03 0,05454005 ! negative regulation of catabolic process GO:0009895 34 23 1,000 9,106E-03 0,05439838 ! response to metal ion GO:0010038 103 70 2,000 9,776E-03 0,05824837 ! regulation of catabolic process GO:0009894 106 70 2,000 9,776E-03 0,05809786 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 9,893E-03 0,05864474 ! mitochondrial membrane organization GO:0007006 39 24 1,000 9,893E-03 0,05849399 ! response to toxin GO:0009636 38 24 1,000 9,893E-03 0,058344 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 9,893E-03 0,05819478 ! glutathione metabolic process GO:0006749 29 24 1,000 9,893E-03 0,05804633 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 9,893E-03 0,05789863 ! muscle cell differentiation GO:0042692 104 71 2,000 0,01016087 0,05931474 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,01016087 0,05916457 ! monosaccharide catabolic process GO:0046365 91 71 2,000 0,01016087 0,05901517 ! response to hypoxia GO:0001666 132 72 2,000 0,01055488 0,06114918 ! regulation of synaptic transmission GO:0050804 109 72 2,000 0,01055488 0,06099553 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,01070956 0,0617343 ! male gonad development GO:0008584 33 25 1,000 0,01070956 0,06157996 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01070956 0,06142639 ! regulation of peptide secretion GO:0002791 34 25 1,000 0,01070956 0,06127359 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01070956 0,06112155 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 1,000 0,01070956 0,06097026 GO:0032943|mononuclear cell proliferation, ! negative regulation of transport GO:0051051 116 73 2,000 0,01095765 0,06222865 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,01095765 0,06207538 ! response to oxygen levels GO:0070482 137 74 2,000 0,01136923 0,0642487 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01155476 0,06513713 ! post-embryonic development GO:0009791 42 26 1,000 0,01155476 0,06497787 ! regulation of ligase activity GO:0051340 114 75 2,000 0,01178963 0,06613697 ! catechol metabolic process GO:0009712 43 27 1,000 0,01242833 0,06955028 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! response to ionizing radiation GO:0010212 47 27 1,000 0,01242833 0,06938146 ! lipid oxidation GO:0034440 38 27 1,000 0,01242833 0,06921347 GO:0019395|fatty acid oxidation, ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01242833 0,06904629 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01242833 0,06887991 ! regulation of transmission of nerve impulse GO:0051969 116 77 2,000 0,01265707 0,06997897 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01332989 0,07352217 ! phenol metabolic process GO:0018958 44 28 1,000 0,01332989 0,07334628 ! cell junction assembly GO:0034329 56 28 1,000 0,01332989 0,07317123 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01332989 0,07299701 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,01332989 0,07282363 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01332989 0,07265106 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01332989 0,07247931 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01332989 0,07230836 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01332989 0,07213823 ! T cell activation GO:0042110 134 79 2,000 0,01356017 0,07321218 ! alcohol catabolic process GO:0046164 104 80 2,000 0,01402516 0,07554537 ! ovulation cycle process GO:0022602 41 29 1,000 0,01425905 0,07662575 ! mismatch repair GO:0006298 34 29 1,000 0,01425905 0,07644714 ! tissue homeostasis GO:0001894 42 29 1,000 0,01425905 0,07626935 GO:0048871|multicellular organismal homeostasis, ! regulation of cell cycle process GO:0010564 122 81 2,000 0,01449915 0,07737363 ! response to protein stimulus GO:0051789 111 81 2,000 0,01449915 0,07719452 ! ossification GO:0001503 134 82 2,000 0,01498214 0,0795818 GO:0060348|bone development, ! collagen metabolic process GO:0032963 40 30 1,000 0,01521545 0,08063485 ! ovulation cycle GO:0042698 43 30 1,000 0,01521545 0,08044948 ! hindbrain development GO:0030902 45 30 1,000 0,01521545 0,08026497 ! fatty acid catabolic process GO:0009062 43 30 1,000 0,01521545 0,08008129 ! adult locomotory behavior GO:0008344 47 30 1,000 0,01521545 0,07989846 ! response to heat GO:0009408 41 30 1,000 0,01521545 0,07971646 ! regulation of defense response GO:0031347 117 84 2,000 0,01597524 0,08350692 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01597524 0,08331757 ! mammary gland development GO:0030879 57 31 1,000 0,0161987 0,08429185 ! glial cell differentiation GO:0010001 55 31 1,000 0,0161987 0,08410158 ! odontogenesis GO:0042476 50 31 1,000 0,0161987 0,08391216 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,0161987 0,08372359 ! metanephros development GO:0001656 58 31 1,000 0,0161987 0,08353587 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 0,01648537 0,08482408 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,01648537 0,08463474 ! regulation of muscle development GO:0048634 48 32 1,000 0,01720843 0,0881501 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,01720843 0,08795421 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,01720843 0,08775919 ! meiosis I GO:0007127 52 32 1,000 0,01720843 0,08756503 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01720843 0,08737173 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01720843 0,08717928 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,0175329 0,08862785 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,0175329 0,08843349 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,01807032 0,09094469 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,01824429 0,09161979 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,01824429 0,09142019 ! sister chromatid segregation GO:0000819 46 33 1,000 0,01824429 0,09122145 ! ear morphogenesis GO:0042471 42 33 1,000 0,01824429 0,09102357 ! cell junction organization GO:0034330 63 33 1,000 0,01824429 0,09082655 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,01824429 0,09063038 ! female gonad development GO:0008585 49 33 1,000 0,01824429 0,09043505 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,01824429 0,09024057 ! positive regulation of cell development GO:0010720 54 33 1,000 0,01824429 0,09004692 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01824429 0,0898541 ! cytokinesis GO:0000910 52 33 1,000 0,01824429 0,08966211 ! reproductive developmental process GO:0003006 127 89 2,000 0,01861684 0,09129796 ! regulation of T cell activation GO:0050863 128 89 2,000 0,01861684 0,09110371 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,01930591 0,09427512 ! feeding behavior GO:0007631 45 34 1,000 0,01930591 0,09407539 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01930591 0,0938765 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01930591 0,09367844 ! neuron migration GO:0001764 46 34 1,000 0,01930591 0,09348123 ! female gamete generation GO:0007292 43 34 1,000 0,01930591 0,09328484 ! polyol metabolic process GO:0019751 44 34 1,000 0,01930591 0,09308927 ! cell fate commitment GO:0045165 141 92 2,000 0,02031121 0,09773176 ! sulfur metabolic process GO:0006790 118 92 2,000 0,02031121 0,09752772 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02039292 0,09771608 ! glycogen metabolic process GO:0005977 48 35 1,000 0,02039292 0,09751293 ! pigment metabolic process GO:0042440 61 35 1,000 0,02039292 0,09731062 ! protein homooligomerization GO:0051260 52 35 1,000 0,02039292 0,09710915 ! carbohydrate catabolic process GO:0016052 121 93 2,000 0,02089428 0,09929099 ! response to oxidative stress GO:0006979 141 94 2,000 0,02148649 0,10189471 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,02150498 0,10177255 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,02150498 0,10156357 ! negative regulation of binding GO:0051100 58 36 1,000 0,02150498 0,10135545 ! tissue remodeling GO:0048771 62 36 1,000 0,02150498 0,10114818 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,02150498 0,10094175 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,02150498 0,10073617 GO:0006073|cellular glucan metabolic process, ! regulation of binding GO:0051098 151 95 2,000 0,02208786 0,10325626 ! angiogenesis GO:0001525 149 95 2,000 0,02208786 0,10304682 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,02264173 0,10541698 ! gliogenesis GO:0042063 71 38 1,000 0,02380283 0,11059901 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02380283 0,11037603 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,02498793 0,11563829 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,02498793 0,11540608 ! male sex differentiation GO:0046661 53 39 1,000 0,02498793 0,11517481 ! JNK cascade GO:0007254 54 39 1,000 0,02498793 0,11494446 ! developmental growth GO:0048589 62 39 1,000 0,02498793 0,11471503 ! response to calcium ion GO:0051592 58 40 1,000 0,02619668 0,12002461 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,02619668 0,11978599 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02619668 0,11954832 ! peptide metabolic process GO:0006518 56 40 1,000 0,02619668 0,11931159 ! T cell differentiation GO:0030217 65 40 1,000 0,02619668 0,1190758 ! B cell differentiation GO:0030183 62 40 1,000 0,02619668 0,11884093 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,02619668 0,118607 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,02619668 0,11837398 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,02742874 0,12369825 ! endosome transport GO:0016197 71 41 1,000 0,02742874 0,12345618 ! mitochondrial transport GO:0006839 60 42 1,000 0,02868379 0,12885297 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,02868379 0,1286018 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,02868379 0,1283516 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,02868379 0,12810237 ! icosanoid metabolic process GO:0006690 61 42 1,000 0,02868379 0,12785411 ! regulation of cell shape GO:0008360 78 42 1,000 0,02868379 0,12760681 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,02996149 0,13303364 ! vesicle organization GO:0016050 79 43 1,000 0,02996149 0,13277732 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,02996149 0,13252198 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03107101 0,13716568 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03107101 0,13690291 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03107101 0,13664115 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03107101 0,13638038 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03107101 0,13612061 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03107101 0,13586182 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03107101 0,13560402 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03107101 0,1353472 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03107101 0,13509134 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03107101 0,13483645 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03107101 0,13458252 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03107101 0,13432955 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03107101 0,13407752 ! tongue development GO:0043586 6 5 0,000 0,03107101 0,13382644 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03107101 0,1335763 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03107101 0,13332709 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03107101 0,13307881 ! cobalt ion transport GO:0006824 9 5 0,000 0,03107101 0,13283145 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03107101 0,13258501 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03107101 0,13233948 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03107101 0,13209486 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03107101 0,13185114 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03107101 0,13160832 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03107101 0,1313664 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03107101 0,13112536 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03107101 0,1308852 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03107101 0,13064592 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03107101 0,13040752 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03107101 0,13016998 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03107101 0,12993331 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03107101 0,1296975 ! malate metabolic process GO:0006108 7 5 0,000 0,03107101 0,12946254 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03107101 0,12922843 ! behavioral response to pain GO:0048266 7 5 0,000 0,03107101 0,12899516 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03107101 0,12876274 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03107101 0,12853115 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03107101 0,12830039 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03107101 0,12807047 ! mating behavior GO:0007617 6 5 0,000 0,03107101 0,12784136 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03107101 0,12761307 ! rhythmic behavior GO:0007622 12 5 0,000 0,03107101 0,1273856 ! copulation GO:0007620 7 5 0,000 0,03107101 0,12715893 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03107101 0,12693307 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03107101 0,12670801 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03107101 0,12648375 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03107101 0,12626028 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03107101 0,1260376 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03107101 0,1258157 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03107101 0,12559459 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03107101 0,12537425 ! response to protozoan GO:0001562 9 5 0,000 0,03107101 0,12515468 ! lymph vessel development GO:0001945 7 5 0,000 0,03107101 0,12493587 ! endochondral ossification GO:0001958 12 5 0,000 0,03107101 0,12471784 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03107101 0,12450056 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03107101 0,12428403 ! anagen GO:0042640 6 5 0,000 0,03107101 0,12406826 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03107101 0,12385324 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03107101 0,12363896 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03107101 0,12342542 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03107101 0,12321262 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03107101 0,12300055 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03107101 0,12278921 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03107101 0,12257859 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03107101 0,1223687 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03107101 0,12215952 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03107101 0,12195106 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03107101 0,1217433 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03107101 0,12153626 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03107101 0,12132991 ! ovulation GO:0030728 6 5 0,000 0,03107101 0,12112427 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03107101 0,12091932 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03107101 0,12071507 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,03107101 0,1205115 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03107101 0,12030862 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03107101 0,12010642 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03107101 0,1199049 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03107101 0,11970405 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03107101 0,11950388 ! polyol catabolic process GO:0046174 7 5 0,000 0,03107101 0,11930437 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03107101 0,11910553 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03107101 0,11890735 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03107101 0,11870983 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03107101 0,11851297 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03107101 0,11831675 ! urea metabolic process GO:0019627 6 5 0,000 0,03107101 0,11812119 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03107101 0,11792627 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03107101 0,11773199 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03107101 0,11753835 ! neutrophil activation GO:0042119 5 5 0,000 0,03107101 0,11734535 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03107101 0,11715298 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03107101 0,11696124 ! response to food GO:0032094 5 5 0,000 0,03107101 0,11677013 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03107101 0,11657964 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03107101 0,11638977 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03107101 0,11620052 ! forebrain neuron development GO:0021884 7 5 0,000 0,03107101 0,11601188 ! melanosome organization GO:0032438 7 5 0,000 0,03107101 0,11582386 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03107101 0,11563644 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03107101 0,11544963 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03107101 0,11526342 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03107101 0,11507781 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03107101 0,1148928 ! nucleoside transport GO:0015858 6 5 0,000 0,03107101 0,11470838 ! nucleoside salvage GO:0043174 7 5 0,000 0,03107101 0,11452455 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03107101 0,11434131 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03107101 0,11415866 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03107101 0,11397659 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03107101 0,1137951 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03107101 0,11361418 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03107101 0,11343384 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03107101 0,11325407 ! depyrimidination GO:0045008 8 5 0,000 0,03107101 0,11307487 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03107101 0,11289624 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03107101 0,11271817 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03107101 0,11254066 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03107101 0,11236371 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03107101 0,11218732 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03107101 0,11201147 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03107101 0,11183618 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03107101 0,11166144 ! monocyte differentiation GO:0030224 8 5 0,000 0,03107101 0,11148724 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03107101 0,11131358 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03107101 0,11114047 ! centrosome duplication GO:0051298 5 5 0,000 0,03107101 0,11096789 ! response to UV-C GO:0010225 6 5 0,000 0,03107101 0,11079584 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03107101 0,11062433 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03107101 0,11045335 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03107101 0,1102829 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03107101 0,11011297 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03107101 0,10994357 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03107101 0,10977468 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03107101 0,10960632 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03107101 0,10943847 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03107101 0,10927113 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03107101 0,10910431 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03107101 0,10893799 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03107101 0,10877218 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03107101 0,10860687 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03107101 0,10844206 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03107101 0,10827776 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03107101 0,10811395 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03107101 0,10795063 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03107101 0,10778781 ! neural tube patterning GO:0021532 6 5 0,000 0,03107101 0,10762548 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03107101 0,10746364 ! histone demethylation GO:0016577 9 5 0,000 0,03107101 0,10730228 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03107101 0,10714141 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03107101 0,10698102 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03107101 0,10682111 ! enteric nervous system development GO:0048484 8 5 0,000 0,03107101 0,10666167 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03107101 0,10650271 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03107101 0,10634423 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03107101 0,10618621 ! transcription termination GO:0006353 8 5 0,000 0,03107101 0,10602866 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03107101 0,10587158 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03107101 0,10571497 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03107101 0,10555882 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03107101 0,10540313 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03107101 0,10524789 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03107101 0,10509312 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03107101 0,1049388 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03107101 0,10478493 ! apical protein localization GO:0045176 6 5 0,000 0,03107101 0,10463151 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03107101 0,10447854 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03107101 0,10432601 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03107101 0,10417394 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03107101 0,1040223 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03107101 0,1038711 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03107101 0,10372035 ! glial cell migration GO:0008347 10 5 0,000 0,03107101 0,10357003 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03107101 0,10342014 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03107101 0,10327069 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03107101 0,10312167 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03107101 0,10297308 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03107101 0,10282492 ! neural plate development GO:0001840 6 5 0,000 0,03107101 0,10267718 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03107101 0,10252987 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03107101 0,10238298 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03107101 0,10223651 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03107101 0,10209046 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03107101 0,10194482 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03107101 0,1017996 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03107101 0,10165479 ! spindle assembly GO:0051225 5 5 0,000 0,03107101 0,1015104 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03107101 0,10136641 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03107101 0,10122283 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03107101 0,10107966 ! organ regeneration GO:0031100 7 5 0,000 0,03107101 0,10093689 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03107101 0,10079453 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03107101 0,10065256 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03107101 0,100511 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03107101 0,10036983 GO:0055081|anion homeostasis, ! regulation of action potential GO:0001508 71 44 1,000 0,03126151 0,10084358 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,03126151 0,10070234 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,03258352 0,10481413 ! unsaturated fatty acid metabolic process GO:0033559 66 46 1,000 0,03392721 0,10898404 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,03529224 0,11321082 ! endocrine system development GO:0035270 83 47 1,000 0,03529224 0,11305314 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,03529224 0,11289591 ! response to temperature stimulus GO:0009266 62 48 1,000 0,03667831 0,11716683 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,03667831 0,11700433 ! heart morphogenesis GO:0003007 65 48 1,000 0,03667831 0,11684227 ! regulation of DNA replication GO:0006275 75 48 1,000 0,03667831 0,11668066 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,03667831 0,1165195 ! tRNA transcription GO:0009304 11 6 0,000 0,03716943 0,11791683 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03716943 0,11775441 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03716943 0,11759243 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03716943 0,11743091 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03716943 0,11726982 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03716943 0,11710918 ! regulation of helicase activity GO:0051095 11 6 0,000 0,03716943 0,11694897 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03716943 0,11678921 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03716943 0,11662988 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03716943 0,11647098 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03716943 0,11631252 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03716943 0,11615448 ! prostate gland development GO:0030850 9 6 0,000 0,03716943 0,11599688 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03716943 0,1158397 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03716943 0,11568295 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03716943 0,11552662 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03716943 0,11537071 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03716943 0,11521523 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03716943 0,11506016 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03716943 0,11490551 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03716943 0,11475127 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03716943 0,11459745 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,03716943 0,11444404 ! neuron adhesion GO:0007158 9 6 0,000 0,03716943 0,11429104 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,03716943 0,11413845 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03716943 0,11398627 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03716943 0,11383449 ! signal peptide processing GO:0006465 8 6 0,000 0,03716943 0,11368311 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03716943 0,11353214 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03716943 0,11338156 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03716943 0,11323139 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03716943 0,11308161 ! opsonization GO:0008228 8 6 0,000 0,03716943 0,11293223 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03716943 0,11278324 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03716943 0,11263465 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03716943 0,11248645 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03716943 0,11233863 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03716943 0,11219121 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03716943 0,11204417 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03716943 0,11189751 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03716943 0,11175124 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03716943 0,11160535 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03716943 0,11145984 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03716943 0,11131471 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03716943 0,11116996 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03716943 0,11102558 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03716943 0,11088158 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03716943 0,11073795 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03716943 0,1105947 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03716943 0,11045181 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03716943 0,11030929 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03716943 0,11016714 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03716943 0,11002535 ! thymic T cell selection GO:0045061 12 6 0,000 0,03716943 0,10988393 ! protein lipoylation GO:0009249 10 6 0,000 0,03716943 0,10974287 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03716943 0,10960218 ! drug transport GO:0015893 6 6 0,000 0,03716943 0,10946184 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03716943 0,10932187 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,03716943 0,10918225 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03716943 0,10904298 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03716943 0,10890408 ! histidine metabolic process GO:0006547 6 6 0,000 0,03716943 0,10876552 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03716943 0,10862732 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03716943 0,10848947 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03716943 0,10835196 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03716943 0,10821481 ! adenohypophysis development GO:0021984 10 6 0,000 0,03716943 0,108078 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03716943 0,10794154 ! hyperosmotic response GO:0006972 8 6 0,000 0,03716943 0,10780542 ! microtubule nucleation GO:0007020 10 6 0,000 0,03716943 0,10766965 ! ER overload response GO:0006983 7 6 0,000 0,03716943 0,10753421 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03716943 0,10739912 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03716943 0,10726437 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03716943 0,10712995 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03716943 0,10699587 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03716943 0,10686212 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,03716943 0,10672871 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03716943 0,10659564 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03716943 0,10646289 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03716943 0,10633047 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03716943 0,10619838 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03716943 0,10606662 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03716943 0,10593519 ! neuron apoptosis GO:0051402 8 6 0,000 0,03716943 0,10580408 ! organic alcohol transport GO:0015850 9 6 0,000 0,03716943 0,1056733 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03716943 0,10554284 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03716943 0,1054127 ! carnitine transport GO:0015879 8 6 0,000 0,03716943 0,10528288 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03716943 0,10515338 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03716943 0,1050242 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03716943 0,10489534 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03716943 0,10476679 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03716943 0,10463855 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03716943 0,10451063 ! parturition GO:0007567 12 6 0,000 0,03716943 0,10438303 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03716943 0,10425573 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03716943 0,10412874 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03716943 0,10400207 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03716943 0,1038757 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03716943 0,10374964 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03716943 0,10362388 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03716943 0,10349843 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03716943 0,10337328 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03716943 0,10324843 ! macrophage differentiation GO:0030225 10 6 0,000 0,03716943 0,10312388 ! astrocyte development GO:0014002 14 6 0,000 0,03716943 0,10299964 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03716943 0,10287569 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03716943 0,10275204 ! interaction with symbiont GO:0051702 8 6 0,000 0,03716943 0,10262869 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03716943 0,10250563 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03716943 0,10238287 ! eating behavior GO:0042755 6 6 0,000 0,03716943 0,10226041 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03716943 0,10213823 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03716943 0,10201635 ! response to copper ion GO:0046688 9 6 0,000 0,03716943 0,10189475 ! DNA topological change GO:0006265 8 6 0,000 0,03716943 0,10177345 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03716943 0,10165244 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03716943 0,10153171 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03716943 0,10141127 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03716943 0,10129111 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03716943 0,10117124 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03716943 0,10105165 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03716943 0,10093235 ! gas homeostasis GO:0033483 11 6 0,000 0,03716943 0,10081332 ! hair follicle maturation GO:0048820 7 6 0,000 0,03716943 0,10069458 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03716943 0,10057612 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03716943 0,10045793 ! Schwann cell development GO:0014044 14 6 0,000 0,03716943 0,10034002 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03716943 0,10022239 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03716943 0,10010503 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03716943 0,09998795 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03716943 0,09987114 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03716943 0,09975461 ! histone ubiquitination GO:0016574 7 6 0,000 0,03716943 0,09963834 ! regulation of meiosis GO:0040020 10 6 0,000 0,03716943 0,09952235 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03716943 0,09940663 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03716943 0,09929117 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03716943 0,09917599 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03716943 0,09906107 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03716943 0,09894641 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03716943 0,09883202 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03716943 0,0987179 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03716943 0,09860404 ! receptor internalization GO:0031623 9 6 0,000 0,03716943 0,09849044 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03716943 0,0983771 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03716943 0,09826402 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03716943 0,0981512 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03716943 0,09803865 ! protein deubiquitination GO:0016579 8 6 0,000 0,03716943 0,09792635 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03716943 0,0978143 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,03716943 0,09770251 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03716943 0,09759098 ! axonal fasciculation GO:0007413 9 6 0,000 0,03716943 0,0974797 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03716943 0,09736868 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03716943 0,09725791 ! midbrain development GO:0030901 6 6 0,000 0,03716943 0,09714739 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03716943 0,09703712 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03716943 0,0969271 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03716943 0,09681733 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03716943 0,0967078 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03716943 0,09659853 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03716943 0,0964895 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03716943 0,09638072 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03716943 0,09627218 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03716943 0,09616389 ! adult feeding behavior GO:0008343 6 6 0,000 0,03716943 0,09605584 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03716943 0,09594804 ! blastocyst growth GO:0001832 15 6 0,000 0,03716943 0,09584047 ! pigment granule transport GO:0051904 12 6 0,000 0,03716943 0,09573315 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03716943 0,09562606 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03716943 0,09551922 ! catecholamine transport GO:0051937 7 6 0,000 0,03716943 0,09541261 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03716943 0,09530624 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03716943 0,09520011 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03716943 0,09509422 ! protein prenylation GO:0018342 10 6 0,000 0,03716943 0,09498855 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03716943 0,09488313 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03716943 0,09477794 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03716943 0,09467298 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03716943 0,09456825 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,03808511 0,09679088 ! germ cell development GO:0007281 68 49 1,000 0,03808511 0,09668404 ! membrane fusion GO:0006944 80 50 1,000 0,03951231 0,1001966 ! lipid modification GO:0030258 73 50 1,000 0,03951231 0,10008625 ! positive regulation of secretion GO:0051047 71 51 1,000 0,04095962 0,1036382 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,04095962 0,10352431 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,04095962 0,10341067 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,04095962 0,10329728 ! adult behavior GO:0030534 80 51 1,000 0,04095962 0,10318414 ! establishment of organelle localization GO:0051656 85 52 1,000 0,04242673 0,1067631 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,04242673 0,10664642 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04322982 0,1085465 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04322982 0,10842813 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04322982 0,10831002 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04322982 0,10819216 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04322982 0,10807456 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04322982 0,10795721 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04322982 0,10784012 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04322982 0,10772329 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04322982 0,1076067 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04322982 0,10749037 ! reproductive behavior GO:0019098 12 7 0,000 0,04322982 0,10737429 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04322982 0,10725846 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04322982 0,10714288 ! oligopeptide transport GO:0006857 11 7 0,000 0,04322982 0,10702755 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04322982 0,10691247 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04322982 0,10679763 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04322982 0,10668304 ! RNA methylation GO:0001510 11 7 0,000 0,04322982 0,1065687 ! pericardium development GO:0060039 8 7 0,000 0,04322982 0,1064546 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04322982 0,10634074 ! fibril organization GO:0043206 13 7 0,000 0,04322982 0,10622713 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04322982 0,10611376 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04322982 0,10600063 ! lipoprotein transport GO:0042953 9 7 0,000 0,04322982 0,10588775 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04322982 0,1057751 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04322982 0,10566269 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04322982 0,10555053 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04322982 0,10543859 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04322982 0,1053269 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04322982 0,10521544 ! chemosensory behavior GO:0007635 9 7 0,000 0,04322982 0,10510422 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04322982 0,10499324 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04322982 0,10488248 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04322982 0,10477196 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04322982 0,10466168 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04322982 0,10455162 ! reflex GO:0060004 12 7 0,000 0,04322982 0,1044418 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04322982 0,10433221 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04322982 0,10422285 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04322982 0,10411371 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04322982 0,10400481 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04322982 0,10389613 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04322982 0,10378768 ! spinal cord patterning GO:0021511 7 7 0,000 0,04322982 0,10367945 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04322982 0,10357145 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04322982 0,10346368 ! adrenal gland development GO:0030325 17 7 0,000 0,04322982 0,10335613 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04322982 0,1032488 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04322982 0,1031417 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04322982 0,10303481 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04322982 0,10292815 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04322982 0,10282171 ! endosome organization GO:0007032 10 7 0,000 0,04322982 0,10271549 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04322982 0,10260949 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04322982 0,10250371 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04322982 0,10239814 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04322982 0,10229279 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04322982 0,10218766 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04322982 0,10208275 ! galactose metabolic process GO:0006012 10 7 0,000 0,04322982 0,10197805 ! vesicle fusion GO:0006906 15 7 0,000 0,04322982 0,10187356 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04322982 0,10176929 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04322982 0,10166523 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04322982 0,10156138 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04322982 0,10145775 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04322982 0,10135433 ! retinol metabolic process GO:0042572 9 7 0,000 0,04322982 0,10125111 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04322982 0,10114811 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04322982 0,10104532 ! rRNA modification GO:0000154 12 7 0,000 0,04322982 0,10094274 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04322982 0,10084036 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04322982 0,10073819 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04322982 0,10063623 ! intermediate filament organization GO:0045109 11 7 0,000 0,04322982 0,10053447 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04322982 0,10043292 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04322982 0,10033158 ! fibrinolysis GO:0042730 9 7 0,000 0,04322982 0,10023044 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04322982 0,1001295 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04322982 0,10002877 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04322982 0,09992824 ! response to tropane GO:0014073 13 7 0,000 0,04322982 0,09982791 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04322982 0,09972778 ! melanosome localization GO:0032400 10 7 0,000 0,04322982 0,09962785 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04322982 0,09952812 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04322982 0,09942859 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04322982 0,09932927 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04322982 0,09923013 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04322982 0,0991312 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04322982 0,09903246 ! mast cell activation GO:0045576 9 7 0,000 0,04322982 0,09893392 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04322982 0,09883558 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04322982 0,09873743 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04322982 0,09863948 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04322982 0,09854172 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04322982 0,09844415 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04322982 0,09834678 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04322982 0,0982496 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04322982 0,09815261 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04322982 0,09805581 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04322982 0,09795921 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04322982 0,09786279 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04322982 0,09776656 ! response to tumor cell GO:0002347 12 7 0,000 0,04322982 0,09767053 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04322982 0,09757468 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04322982 0,09747901 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04322982 0,09738354 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04322982 0,09728825 ! diuresis GO:0030146 12 7 0,000 0,04322982 0,09719315 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04322982 0,09709824 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04322982 0,09700351 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04322982 0,09690896 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04322982 0,0968146 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04322982 0,09672042 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04322982 0,09662643 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04322982 0,09653262 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04322982 0,09643899 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04322982 0,09634554 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04322982 0,09625227 ! lymph node development GO:0048535 9 7 0,000 0,04322982 0,09615918 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04322982 0,09606627 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04322982 0,09597355 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04322982 0,095881 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04322982 0,09578863 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04322982 0,09569643 ! ATP catabolic process GO:0006200 10 7 0,000 0,04322982 0,09560442 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04322982 0,09551258 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04322982 0,09542092 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04322982 0,09532943 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04322982 0,09523812 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04322982 0,09514698 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04322982 0,09505602 ! muscle adaptation GO:0043500 12 7 0,000 0,04322982 0,09496523 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04322982 0,09487461 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04322982 0,09478417 ! retina homeostasis GO:0001895 9 7 0,000 0,04322982 0,0946939 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04322982 0,0946038 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04322982 0,09451387 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04322982 0,09442412 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04322982 0,09433453 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04322982 0,09424511 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04322982 0,09415587 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,04391333 0,09555408 ! kidney development GO:0001822 90 53 1,000 0,04391333 0,09546377 ! amino acid transport GO:0006865 84 54 1,000 0,04541914 0,09864402 ! regulation of mitosis GO:0007088 84 54 1,000 0,04541914 0,09855096 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,04541914 0,09845807 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,04541914 0,09836536 ! detection of external stimulus GO:0009581 66 54 1,000 0,04541914 0,09827283 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,04541914 0,09818047 ! mesoderm development GO:0007498 76 55 1,000 0,04694385 0,10138108 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,04848717 0,10461584 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,04848717 0,10451779 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04925241 0,10606793 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04925241 0,10596871 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04925241 0,10586967 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04925241 0,10577082 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04925241 0,10567215 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04925241 0,10557367 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04925241 0,10547537 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04925241 0,10537725 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,04925241 0,10527932 ! phosphate transport GO:0006817 10 8 0,000 0,04925241 0,10518157 ! N-glycan processing GO:0006491 12 8 0,000 0,04925241 0,10508399 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04925241 0,1049866 ! UTP metabolic process GO:0046051 8 8 0,000 0,04925241 0,10488939 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04925241 0,10479236 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04925241 0,10469551 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04925241 0,10459884 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04925241 0,10450235 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04925241 0,10440603 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04925241 0,1043099 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04925241 0,10421393 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04925241 0,10411815 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04925241 0,10402254 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04925241 0,10392711 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,04925241 0,10383185 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04925241 0,10373676 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04925241 0,10364185 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04925241 0,10354712 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04925241 0,10345255 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04925241 0,10335816 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04925241 0,10326394 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04925241 0,1031699 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04925241 0,10307602 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04925241 0,10298231 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04925241 0,10288878 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04925241 0,10279541 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04925241 0,10270222 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04925241 0,10260919 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04925241 0,10251633 ! macrophage activation GO:0042116 12 8 0,000 0,04925241 0,10242364 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04925241 0,10233112 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04925241 0,10223876 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04925241 0,10214657 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04925241 0,10205455 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04925241 0,10196269 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04925241 0,10187099 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04925241 0,10177947 ! ruffle organization GO:0031529 11 8 0,000 0,04925241 0,1016881 ! osteoblast development GO:0002076 13 8 0,000 0,04925241 0,1015969 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04925241 0,10150587 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04925241 0,10141499 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04925241 0,10132428 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04925241 0,10123373 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04925241 0,10114334 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04925241 0,10105312 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04925241 0,10096305 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04925241 0,10087315 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04925241 0,1007834 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,04925241 0,10069382 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,04925241 0,10060439 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04925241 0,10051513 ! segment specification GO:0007379 10 8 0,000 0,04925241 0,10042602 ! cellular extravasation GO:0045123 11 8 0,000 0,04925241 0,10033706 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04925241 0,10024827 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04925241 0,10015963 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04925241 0,10007115 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04925241 0,09998283 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04925241 0,09989466 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04925241 0,09980665 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04925241 0,09971879 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04925241 0,09963109 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04925241 0,09954354 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04925241 0,09945614 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04925241 0,0993689 ! icosanoid secretion GO:0032309 12 8 0,000 0,04925241 0,09928181 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04925241 0,09919487 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04925241 0,09910809 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04925241 0,09902146 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04925241 0,09893497 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04925241 0,09884864 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04925241 0,09876246 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04925241 0,09867643 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04925241 0,09859055 ! sterol catabolic process GO:0016127 9 8 0,000 0,04925241 0,09850482 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04925241 0,09841924 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04925241 0,09833381 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04925241 0,09824852 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04925241 0,09816338 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04925241 0,09807839 ! prophase GO:0051324 11 8 0,000 0,04925241 0,09799355 ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04925241 0,09790886 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04925241 0,09782431 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04925241 0,0977399 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04925241 0,09765564 ! hormone catabolic process GO:0042447 13 8 0,000 0,04925241 0,09757153 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04925241 0,09748756 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04925241 0,09740374 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04925241 0,09732006 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04925241 0,09723652 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04925241 0,09715313 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04925241 0,09706988 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04925241 0,09698677 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04925241 0,0969038 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04925241 0,09682098 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04925241 0,0967383 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04925241 0,09665576 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04925241 0,09657336 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04925241 0,0964911 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,05004881 0,09796788 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,05004881 0,09788458 ! secondary metabolic process GO:0019748 84 57 1,000 0,05004881 0,09780141 ! gonad development GO:0008406 79 57 1,000 0,05004881 0,09771839 ! viral reproductive process GO:0022415 87 58 1,000 0,05162849 0,10071715 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,05322591 0,10374543 ! lung development GO:0030324 94 59 1,000 0,05322591 0,10365758 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,05322591 0,10356988 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05523743 0,10739315 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05523743 0,10730244 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05523743 0,10721189 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05523743 0,10712149 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05523743 0,10703125 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05523743 0,10694115 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05523743 0,10685121 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05523743 0,10676142 ! GTP metabolic process GO:0046039 9 9 0,000 0,05523743 0,10667178 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05523743 0,10658229 ! social behavior GO:0035176 14 9 0,000 0,05523743 0,10649295 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05523743 0,10640376 ! artery development GO:0060840 19 9 0,000 0,05523743 0,10631472 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05523743 0,10622583 ! response to pain GO:0048265 16 9 0,000 0,05523743 0,10613709 ! protein complex disassembly GO:0043241 17 9 0,000 0,05523743 0,10604849 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05523743 0,10596004 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05523743 0,10587174 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05523743 0,10578359 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05523743 0,10569558 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,05523743 0,10560772 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05523743 0,10552001 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05523743 0,10543244 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05523743 0,10534502 ! protein targeting to ER GO:0045047 19 9 0,000 0,05523743 0,10525774 ! endoderm development GO:0007492 12 9 0,000 0,05523743 0,10517061 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05523743 0,10508362 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05523743 0,10499677 ! arginine catabolic process GO:0006527 10 9 0,000 0,05523743 0,10491007 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05523743 0,10482351 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05523743 0,10473709 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05523743 0,10465082 ! V(D)J recombination GO:0033151 12 9 0,000 0,05523743 0,10456468 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05523743 0,10447869 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05523743 0,10439284 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05523743 0,10430714 ! mannose metabolic process GO:0006013 9 9 0,000 0,05523743 0,10422157 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05523743 0,10413614 ! receptor clustering GO:0043113 15 9 0,000 0,05523743 0,10405085 ! epithelial cell development GO:0002064 10 9 0,000 0,05523743 0,10396571 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05523743 0,1038807 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05523743 0,10379583 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05523743 0,1037111 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05523743 0,1036265 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05523743 0,10354205 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05523743 0,10345773 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05523743 0,10337355 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05523743 0,10328951 ! DNA ligation GO:0006266 14 9 0,000 0,05523743 0,1032056 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05523743 0,10312183 ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05523743 0,10303819 ! erythrocyte development GO:0048821 11 9 0,000 0,05523743 0,10295469 ! renal water homeostasis GO:0003091 14 9 0,000 0,05523743 0,10287133 ! postreplication repair GO:0006301 11 9 0,000 0,05523743 0,1027881 ! mRNA cleavage GO:0006379 13 9 0,000 0,05523743 0,10270501 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05523743 0,10262204 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05523743 0,10253922 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05523743 0,10245653 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05523743 0,10237397 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05523743 0,10229154 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,05523743 0,10220925 ! acid secretion GO:0046717 14 9 0,000 0,05523743 0,10212708 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05523743 0,10204505 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05523743 0,10196316 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05523743 0,10188139 ! purine base metabolic process GO:0006144 18 9 0,000 0,05523743 0,10179975 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05523743 0,10171825 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05523743 0,10163687 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05523743 0,10155563 ! detection of calcium ion GO:0005513 13 9 0,000 0,05523743 0,10147451 ! blastocyst formation GO:0001825 12 9 0,000 0,05523743 0,10139353 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05523743 0,10131267 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05523743 0,10123195 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05523743 0,10115135 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05523743 0,10107088 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05523743 0,10099053 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05523743 0,10091032 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05523743 0,10083023 ! prepulse inhibition GO:0060134 14 9 0,000 0,05523743 0,10075027 ! embryonic placenta development GO:0001892 12 9 0,000 0,05523743 0,10067044 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05523743 0,10059073 ! insulin secretion GO:0030073 17 9 0,000 0,05523743 0,10051115 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05523743 0,10043169 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05523743 0,10035236 ! nucleus localization GO:0051647 15 9 0,000 0,05523743 0,10027316 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05523743 0,10019408 ! localization within membrane GO:0051668 15 9 0,000 0,05523743 0,10011512 ! meiosis GO:0007126 96 61 1,000 0,0564729 0,10227375 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 1,000 0,0564729 0,10219328 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,0564729 0,10211294 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,0564729 0,10203273 ! respiratory tube development GO:0030323 99 62 1,000 0,0581219 0,10492965 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,0581219 0,10484735 ! meiotic cell cycle GO:0051321 97 62 1,000 0,0581219 0,10476518 ! organelle localization GO:0051640 96 62 1,000 0,0581219 0,10468314 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,05978754 0,10759887 GO:0090046|regulation of transcription regulator activity, ! viral reproduction GO:0016032 92 63 1,000 0,05978754 0,10751474 ! regulation of lipase activity GO:0060191 109 63 1,000 0,05978754 0,10743074 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,06118512 0,10985618 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06118512 0,10977049 ! neuron fate specification GO:0048665 11 10 0,000 0,06118512 0,10968493 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06118512 0,10959951 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06118512 0,10951421 ! thyroid gland development GO:0030878 19 10 0,000 0,06118512 0,10942906 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06118512 0,10934403 ! synapsis GO:0007129 13 10 0,000 0,06118512 0,10925913 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06118512 0,10917437 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06118512 0,10908974 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,06118512 0,10900524 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06118512 0,10892087 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,06118512 0,10883663 ! androgen metabolic process GO:0008209 13 10 0,000 0,06118512 0,10875252 ! phospholipid efflux GO:0033700 16 10 0,000 0,06118512 0,10866854 ! hippocampus development GO:0021766 19 10 0,000 0,06118512 0,1085847 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,06118512 0,10850098 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06118512 0,10841738 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06118512 0,10833392 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06118512 0,10825059 ! pathogenesis GO:0009405 13 10 0,000 0,06118512 0,10816738 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06118512 0,1080843 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06118512 0,10800135 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06118512 0,10791853 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,06118512 0,10783584 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06118512 0,10775327 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06118512 0,10767082 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06118512 0,10758851 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06118512 0,10750631 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06118512 0,10742425 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06118512 0,10734231 ! response to X-ray GO:0010165 16 10 0,000 0,06118512 0,10726049 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06118512 0,1071788 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06118512 0,10709723 ! forebrain cell migration GO:0021885 17 10 0,000 0,06118512 0,10701579 ! lipid digestion GO:0044241 15 10 0,000 0,06118512 0,10693447 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06118512 0,10685328 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06118512 0,1067722 ! UV protection GO:0009650 14 10 0,000 0,06118512 0,10669125 ! entry into host cell GO:0030260 20 10 0,000 0,06118512 0,10661043 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06118512 0,10652972 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06118512 0,10644914 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,06118512 0,10636868 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06118512 0,10628834 ! regulation of organ growth GO:0046620 11 10 0,000 0,06118512 0,10620812 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06118512 0,10612803 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06118512 0,10604805 ! embryonic axis specification GO:0000578 12 10 0,000 0,06118512 0,1059682 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06118512 0,10588846 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06118512 0,10580885 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06118512 0,10572935 ! cranial nerve development GO:0021545 12 10 0,000 0,06118512 0,10564997 ! fucose catabolic process GO:0019317 16 10 0,000 0,06118512 0,10557072 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,06118512 0,10549158 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06118512 0,10541256 ! protein sumoylation GO:0016925 12 10 0,000 0,06118512 0,10533366 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06118512 0,10525487 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06118512 0,10517621 ! zymogen activation GO:0031638 14 10 0,000 0,06118512 0,10509766 ! salivary gland development GO:0007431 22 10 0,000 0,06118512 0,10501923 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06118512 0,10494091 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06118512 0,10486272 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06118512 0,10478463 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06118512 0,10470667 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06118512 0,10462882 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06118512 0,10455109 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06118512 0,10447347 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06118512 0,10439597 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06118512 0,10431858 ! detection of bacterium GO:0016045 10 10 0,000 0,06118512 0,10424131 ! embryonic gut development GO:0048566 11 10 0,000 0,06118512 0,10416415 ! activation of innate immune response GO:0002218 10 10 0,000 0,06118512 0,1040871 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06118512 0,10401017 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,06118512 0,10393336 ! developmental induction GO:0031128 13 10 0,000 0,06118512 0,10385665 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06118512 0,10378006 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06118512 0,10370358 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06118512 0,10362722 ! respiratory system development GO:0060541 100 64 1,000 0,06146956 0,10403237 ! reproductive structure development GO:0048608 90 65 1,000 0,06316768 0,10682769 ! B cell activation GO:0042113 104 65 1,000 0,06316768 0,1067492 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,06316768 0,10667082 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,06316768 0,10659256 ! activation of immune response GO:0002253 83 65 1,000 0,06316768 0,10651441 ! axon guidance GO:0007411 99 66 1,000 0,06488164 0,10932437 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,06661117 0,11215643 ! respiratory burst GO:0045730 14 11 0,000 0,06709569 0,11288961 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,06709569 0,11280709 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,06709569 0,11272469 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,06709569 0,11264241 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,06709569 0,11256025 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,06709569 0,1124782 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,06709569 0,11239628 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,06709569 0,11231448 ! RNA polyadenylation GO:0043631 19 11 0,000 0,06709569 0,1122328 ! mating GO:0007618 14 11 0,000 0,06709569 0,11215123 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,06709569 0,11206979 ! T cell proliferation GO:0042098 20 11 0,000 0,06709569 0,11198846 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,06709569 0,11190725 ! bone resorption GO:0045453 16 11 0,000 0,06709569 0,11182616 ! regulated secretory pathway GO:0045055 14 11 0,000 0,06709569 0,11174518 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,06709569 0,11166432 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,06709569 0,11158358 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,06709569 0,11150296 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,06709569 0,11142245 ! syncytium formation GO:0006949 15 11 0,000 0,06709569 0,11134206 ! plasma membrane organization GO:0007009 18 11 0,000 0,06709569 0,11126179 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,06709569 0,11118163 ! mitotic spindle organization GO:0007052 15 11 0,000 0,06709569 0,11110158 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,06709569 0,11102165 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,06709569 0,11094184 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,06709569 0,11086214 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,06709569 0,11078255 ! adult heart development GO:0007512 11 11 0,000 0,06709569 0,11070308 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,06709569 0,11062373 ! temperature homeostasis GO:0001659 16 11 0,000 0,06709569 0,11054448 ! L-glutamate transport GO:0015813 16 11 0,000 0,06709569 0,11046535 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,06709569 0,11038634 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,06709569 0,11030743 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,06709569 0,11022864 ! stem cell development GO:0048864 29 11 0,000 0,06709569 0,11014996 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,06709569 0,1100714 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,06709569 0,10999294 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,06709569 0,1099146 ! vasoconstriction GO:0042310 15 11 0,000 0,06709569 0,10983637 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,06709569 0,10975825 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,06709569 0,10968024 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,06709569 0,10960234 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,06709569 0,10952455 ! ribosome assembly GO:0042255 13 11 0,000 0,06709569 0,10944688 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,06709569 0,10936931 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,06709569 0,10929185 ! chromatin silencing GO:0006342 19 11 0,000 0,06709569 0,10921451 ! nucleosome positioning GO:0016584 13 11 0,000 0,06709569 0,10913727 ! regulation of isotype switching GO:0045191 19 11 0,000 0,06709569 0,10906014 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,06709569 0,10898312 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,06709569 0,10890621 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,06709569 0,10882941 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,06709569 0,10875271 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,06709569 0,10867612 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,06709569 0,10859965 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,06709569 0,10852327 ! male genitalia development GO:0030539 13 11 0,000 0,06709569 0,10844701 ! cholesterol efflux GO:0033344 19 11 0,000 0,06709569 0,10837085 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,06709569 0,1082948 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,06709569 0,10821886 ! germ cell migration GO:0008354 18 11 0,000 0,06709569 0,10814302 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,06709569 0,10806729 ! defense response to fungus GO:0050832 12 11 0,000 0,06709569 0,10799167 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,06709569 0,10791615 ! lysogeny GO:0030069 18 11 0,000 0,06709569 0,10784074 GO:0019047|provirus integration, ! acrosome reaction GO:0007340 13 11 0,000 0,06709569 0,10776543 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,06709569 0,10769023 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,06835602 0,10963657 ! rhythmic process GO:0048511 105 68 1,000 0,06835602 0,10956017 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,07011593 0,11230267 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,07011593 0,11222452 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,07189065 0,11498504 ! humoral immune response GO:0006959 86 70 1,000 0,07189065 0,11490513 ! amine transport GO:0015837 101 70 1,000 0,07189065 0,11482534 ! lactation GO:0007595 20 12 0,000 0,0729694 0,11646746 ! reproductive cellular process GO:0048610 14 12 0,000 0,0729694 0,1163867 ! tRNA modification GO:0006400 14 12 0,000 0,0729694 0,11630604 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,0729694 0,11622549 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,0729694 0,11614506 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,0729694 0,11606474 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,0729694 0,11598453 ! non-recombinational repair GO:0000726 19 12 0,000 0,0729694 0,11590443 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,0729694 0,11582444 ! peroxisomal transport GO:0043574 21 12 0,000 0,0729694 0,11574456 ! cartilage condensation GO:0001502 18 12 0,000 0,0729694 0,11566479 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,0729694 0,11558513 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,0729694 0,11550558 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,0729694 0,11542614 ! heart looping GO:0001947 15 12 0,000 0,0729694 0,11534681 ! palate development GO:0060021 15 12 0,000 0,0729694 0,11526759 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,0729694 0,11518848 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,0729694 0,11510948 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,0729694 0,11503058 ! arginine metabolic process GO:0006525 13 12 0,000 0,0729694 0,11495179 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,0729694 0,11487311 ! methionine metabolic process GO:0006555 13 12 0,000 0,0729694 0,11479454 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,0729694 0,11471607 ! Golgi organization GO:0007030 18 12 0,000 0,0729694 0,11463771 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,0729694 0,11455946 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,0729694 0,11448132 ! monoamine transport GO:0015844 13 12 0,000 0,0729694 0,11440328 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0729694 0,11432535 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,0729694 0,11424753 ! L-amino acid transport GO:0015807 20 12 0,000 0,0729694 0,11416981 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,0729694 0,11409219 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,0729694 0,11401468 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,0729694 0,11393728 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,0729694 0,11385998 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,0729694 0,11378279 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,0729694 0,1137057 ! cerebellum development GO:0021549 13 12 0,000 0,0729694 0,11362872 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,0729694 0,11355184 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,0729694 0,11347506 ! histone acetylation GO:0016573 23 12 0,000 0,0729694 0,11339839 ! histone methylation GO:0016571 15 12 0,000 0,0729694 0,11332182 ! autonomic nervous system development GO:0048483 23 12 0,000 0,0729694 0,11324535 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,0729694 0,11316899 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,0729694 0,11309273 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,0729694 0,11301658 ! regulation of epidermis development GO:0045682 17 12 0,000 0,0729694 0,11294052 ! intestinal absorption GO:0050892 19 12 0,000 0,0729694 0,11286457 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,0729694 0,11278872 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,0729694 0,11271297 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,0729694 0,11263733 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,0729694 0,11256178 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,0729694 0,11248634 ! microspike assembly GO:0030035 23 12 0,000 0,0729694 0,11241099 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,0729694 0,11233575 ! response to cold GO:0009409 14 12 0,000 0,0729694 0,11226061 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,07367992 0,11327794 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,07548349 0,11597329 ! tube morphogenesis GO:0035239 118 73 1,000 0,07730112 0,11868663 ! cellular lipid catabolic process GO:0044242 105 73 1,000 0,07730112 0,11860745 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,07880645 0,12083656 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07880645 0,12075606 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07880645 0,12067566 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07880645 0,12059537 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,07880645 0,12051519 ! water transport GO:0006833 17 13 0,000 0,07880645 0,12043511 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07880645 0,12035514 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07880645 0,12027528 ! lipid localization GO:0010876 24 13 0,000 0,07880645 0,12019552 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07880645 0,12011587 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07880645 0,12003632 ! organelle fusion GO:0048284 28 13 0,000 0,07880645 0,11995688 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07880645 0,11987754 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,07880645 0,11979831 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,07880645 0,11971918 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07880645 0,11964016 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07880645 0,11956124 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07880645 0,11948243 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07880645 0,11940372 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07880645 0,11932511 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07880645 0,11924661 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07880645 0,11916821 ! NAD metabolic process GO:0019674 21 13 0,000 0,07880645 0,11908991 ! exocrine system development GO:0035272 27 13 0,000 0,07880645 0,11901172 ! bone mineralization GO:0030282 15 13 0,000 0,07880645 0,11893362 ! regulation of exocytosis GO:0017157 17 13 0,000 0,07880645 0,11885563 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,07880645 0,11877775 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07880645 0,11869996 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07880645 0,11862228 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07880645 0,1185447 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,07880645 0,11846722 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,07880645 0,11838984 ! genitalia development GO:0048806 15 13 0,000 0,07880645 0,11831256 ! regulation of cellular pH GO:0030641 20 13 0,000 0,07880645 0,11823538 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,07880645 0,11815831 ! tissue regeneration GO:0042246 21 13 0,000 0,07880645 0,11808133 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,07880645 0,11800446 ! cofactor transport GO:0051181 19 13 0,000 0,07880645 0,11792768 ! NADP metabolic process GO:0006739 18 13 0,000 0,07880645 0,117851 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07880645 0,11777443 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,07880645 0,11769795 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07880645 0,11762157 ! gas transport GO:0015669 18 13 0,000 0,07880645 0,11754529 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07880645 0,11746911 ! regulation of axon extension GO:0030516 23 13 0,000 0,07880645 0,11739303 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07880645 0,11731705 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07880645 0,11724117 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07880645 0,11716538 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07880645 0,11708969 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07880645 0,1170141 ! protein import into nucleus GO:0006606 118 74 1,000 0,07913256 0,11742251 ! blood coagulation GO:0007596 116 75 1,000 0,08097757 0,12008279 GO:0050817|coagulation, ! nuclear import GO:0051170 121 75 1,000 0,08097757 0,12000542 ! response to unfolded protein GO:0006986 99 76 1,000 0,08283591 0,12268036 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,08283591 0,12260141 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,08460709 0,12514232 ! superoxide anion generation GO:0042554 18 14 0,000 0,08460709 0,12506189 ! neuron maturation GO:0042551 21 14 0,000 0,08460709 0,12498157 ! regulation of S phase GO:0033261 18 14 0,000 0,08460709 0,12490135 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,08460709 0,12482123 ! myotube differentiation GO:0014902 21 14 0,000 0,08460709 0,12474122 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,08460709 0,12466131 ! inositol metabolic process GO:0006020 20 14 0,000 0,08460709 0,1245815 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08460709 0,12450179 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08460709 0,12442219 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08460709 0,12434269 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08460709 0,12426328 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08460709 0,12418398 ! limbic system development GO:0021761 25 14 0,000 0,08460709 0,12410479 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08460709 0,12402569 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,08460709 0,12394669 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08460709 0,12386779 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08460709 0,123789 ! glycine metabolic process GO:0006544 22 14 0,000 0,08460709 0,1237103 ! pituitary gland development GO:0021983 23 14 0,000 0,08460709 0,1236317 ! cellular response to starvation GO:0009267 21 14 0,000 0,08460709 0,12355321 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,08460709 0,12347481 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,08460709 0,12339651 ! regulation of heart rate GO:0002027 23 14 0,000 0,08460709 0,12331832 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08460709 0,12324022 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08460709 0,12316222 ! embryo implantation GO:0007566 27 14 0,000 0,08460709 0,12308432 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,08460709 0,12300651 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,08460709 0,12292881 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08460709 0,1228512 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08460709 0,12277369 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08460709 0,12269628 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,08460709 0,12261897 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08460709 0,12254175 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08460709 0,12246463 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08460709 0,12238761 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08460709 0,12231069 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08460709 0,12223386 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,08460709 0,12215713 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08460709 0,12208049 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08460709 0,12200395 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,08460709 0,12192751 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,08460709 0,12185116 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08460709 0,12177491 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08460709 0,12169875 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08460709 0,12162269 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,08460709 0,12154672 ! cell killing GO:0001906 20 14 0,000 0,08460709 0,12147085 ! cilium assembly GO:0042384 20 14 0,000 0,08460709 0,12139507 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08460709 0,12131939 ! regulation of DNA binding GO:0051101 119 77 1,000 0,08470735 0,12138748 ! sex differentiation GO:0007548 105 77 1,000 0,08470735 0,12131189 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,09037153 0,12934319 ! positive regulation of cell size GO:0045793 20 15 0,000 0,09037153 0,12926276 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,09037153 0,12918242 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,09037153 0,12910218 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,09037153 0,12902204 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,09037153 0,12894201 ! lipid phosphorylation GO:0046834 23 15 0,000 0,09037153 0,12886207 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,09037153 0,12878223 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,09037153 0,12870248 ! bile acid metabolic process GO:0008206 22 15 0,000 0,09037153 0,12862284 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,09037153 0,1285433 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,09037153 0,12846385 ! adult walking behavior GO:0007628 25 15 0,000 0,09037153 0,1283845 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,09037153 0,12830525 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,09037153 0,1282261 ! centrosome cycle GO:0007098 16 15 0,000 0,09037153 0,12814705 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,09037153 0,12806809 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,09037153 0,12798923 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,09037153 0,12791047 ! cerebral cortex development GO:0021987 29 15 0,000 0,09037153 0,1278318 ! response to osmotic stress GO:0006970 22 15 0,000 0,09037153 0,12775323 ! vesicle coating GO:0006901 25 15 0,000 0,09037153 0,12767476 ! DNA integration GO:0015074 22 15 0,000 0,09037153 0,12759639 ! peptide secretion GO:0002790 27 15 0,000 0,09037153 0,12751811 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,09037153 0,12743992 ! regulation of vasodilation GO:0042312 24 15 0,000 0,09037153 0,12736183 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,09037153 0,12728384 ! neuron recognition GO:0008038 22 15 0,000 0,09037153 0,12720594 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,09037153 0,12712814 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,09037153 0,12705044 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,09037153 0,12697282 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,09037153 0,12689531 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,09037153 0,12681788 ! organic cation transport GO:0015695 19 15 0,000 0,09037153 0,12674056 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,09037153 0,12666332 GO:0033014|tetrapyrrole biosynthetic process, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,09037153 0,12658618 ! peptide hormone processing GO:0016486 19 15 0,000 0,09037153 0,12650914 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,09037153 0,12643219 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,09039788 0,12639218 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,09039788 0,12631539 ! forebrain development GO:0030900 131 80 1,000 0,09039788 0,12623869 ! hemostasis GO:0007599 125 81 1,000 0,09231937 0,12884378 ! detection of stimulus GO:0051606 108 82 1,000 0,0942528 0,13146237 ! protein secretion GO:0009306 27 16 0,000 0,09609999 0,13395757 ! hormone secretion GO:0046879 25 16 0,000 0,09609999 0,13387643 ! bone remodeling GO:0046849 24 16 0,000 0,09609999 0,13379539 ! endothelial cell migration GO:0043542 22 16 0,000 0,09609999 0,13371445 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,09609999 0,13363361 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,09609999 0,13355286 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09609999 0,13347221 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,09609999 0,13339166 ! glial cell development GO:0021782 24 16 0,000 0,09609999 0,13331121 ! patterning of blood vessels GO:0001569 24 16 0,000 0,09609999 0,13323085 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,09609999 0,13315059 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,09609999 0,13307043 ! protein polyubiquitination GO:0000209 26 16 0,000 0,09609999 0,13299037 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,09609999 0,1329104 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,09609999 0,13283052 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,09609999 0,13275074 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,09609999 0,13267106 ! protein export from nucleus GO:0006611 24 16 0,000 0,09609999 0,13259147 ! negative regulation of immune response GO:0050777 28 16 0,000 0,09609999 0,13251198 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,09609999 0,13243259 ! DNA replication initiation GO:0006270 25 16 0,000 0,09609999 0,13235329 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,09609999 0,13227408 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,09609999 0,13219497 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,09609999 0,13211595 ! diencephalon development GO:0021536 25 16 0,000 0,09609999 0,13203703 ! neural crest cell migration GO:0001755 24 16 0,000 0,09609999 0,1319582 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,09609999 0,13187947 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,09609999 0,13180083 ! steroid catabolic process GO:0006706 22 16 0,000 0,09609999 0,13172228 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,09609999 0,13164383 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,09609999 0,13156547 ! sperm-egg recognition GO:0035036 16 16 0,000 0,09609999 0,1314872 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,09609999 0,13140903 ! nerve development GO:0021675 18 16 0,000 0,09609999 0,13133095 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,09609999 0,13125296 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,09619795 0,13130878 ! rRNA metabolic process GO:0016072 107 85 1,000 0,10012254 0,13658472 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,10012254 0,13650375 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,10012254 0,13642289 ! regulation of protein localization GO:0032880 132 85 1,000 0,10012254 0,13634212 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,10179271 0,13853446 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,10179271 0,13845254 ! negative regulation of defense response GO:0031348 19 17 0,000 0,10179271 0,13837071 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,10179271 0,13828898 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,10179271 0,13820734 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,10179271 0,1381258 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,10179271 0,13804436 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,10179271 0,13796302 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,10179271 0,13788176 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,10179271 0,13780061 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,10179271 0,13771955 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,10179271 0,13763859 ! keratinization GO:0031424 17 17 0,000 0,10179271 0,13755772 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,10179271 0,13747694 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,10179271 0,13739627 ! retinoid metabolic process GO:0001523 22 17 0,000 0,10179271 0,13731568 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,10179271 0,13723519 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,10179271 0,1371548 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,10179271 0,13707449 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,10179271 0,13699429 ! membrane budding GO:0006900 29 17 0,000 0,10179271 0,13691417 ! heme metabolic process GO:0042168 27 17 0,000 0,10179271 0,13683415 ! actin filament bundle formation GO:0051017 26 17 0,000 0,10179271 0,13675423 ! body fluid secretion GO:0007589 27 17 0,000 0,10179271 0,13667439 ! stem cell differentiation GO:0048863 36 17 0,000 0,10179271 0,13659465 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,10179271 0,13651501 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,10179271 0,13643545 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,10179271 0,13635599 ! sensory perception of pain GO:0019233 23 17 0,000 0,10179271 0,13627662 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,10179271 0,13619735 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,10179271 0,13611816 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,10179271 0,13603907 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,10179271 0,13596007 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,10179271 0,13588116 ! cell-cell junction organization GO:0045216 25 17 0,000 0,10179271 0,13580234 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,10179271 0,13572362 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,10179271 0,13564498 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,10179271 0,13556644 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,10179271 0,13548798 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,10179271 0,13540962 ! female pregnancy GO:0007565 130 87 1,000 0,10409139 0,13838739 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,10609188 0,14096552 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 1,000 0,10609188 0,14088413 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,1074499 0,14260518 ! positive regulation of translation GO:0045727 28 18 0,000 0,1074499 0,14252294 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,1074499 0,14244079 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,1074499 0,14235874 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,1074499 0,14227678 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,1074499 0,14219492 ! cAMP metabolic process GO:0046058 33 18 0,000 0,1074499 0,14211315 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,1074499 0,14203148 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,1074499 0,1419499 ! axis specification GO:0009798 26 18 0,000 0,1074499 0,14186841 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,1074499 0,14178702 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,1074499 0,14170572 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,1074499 0,14162451 ! glutamine metabolic process GO:0006541 23 18 0,000 0,1074499 0,1415434 ! central nervous system neuron development GO:0021954 30 18 0,000 0,1074499 0,14146238 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,1074499 0,14138145 ! fucose metabolic process GO:0006004 26 18 0,000 0,1074499 0,14130061 ! response to fungus GO:0009620 19 18 0,000 0,1074499 0,14121987 ! peptide cross-linking GO:0018149 31 18 0,000 0,1074499 0,14113922 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,1074499 0,14105866 ! heart process GO:0003015 27 18 0,000 0,1074499 0,14097819 GO:0060047|heart contraction, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,1074499 0,14089782 ! somitogenesis GO:0001756 24 18 0,000 0,1074499 0,14081753 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,1074499 0,14073734 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,1074499 0,14065724 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,1074499 0,14057723 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,1074499 0,14049731 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,1074499 0,14041748 ! vitamin transport GO:0051180 24 18 0,000 0,1074499 0,14033775 ! hormone transport GO:0009914 27 18 0,000 0,1074499 0,1402581 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,1074499 0,14017854 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,1074499 0,14009908 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,1074499 0,1400197 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,1074499 0,13994041 ! cell-cell recognition GO:0009988 20 18 0,000 0,1074499 0,13986122 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,1074499 0,13978211 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,1074499 0,13970309 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,1074499 0,13962416 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,1081028 0,14039324 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,1081028 0,14031401 ! leukocyte differentiation GO:0002521 143 90 1,000 0,11012394 0,14285677 ! response to virus GO:0009615 122 91 1,000 0,1121551 0,14540966 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,11307178 0,14651555 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,11307178 0,14643305 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,11307178 0,14635064 ! positive regulation of ossification GO:0045778 30 19 0,000 0,11307178 0,14626833 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,11307178 0,14618611 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,11307178 0,14610399 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,11307178 0,14602195 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,11307178 0,14594001 ! sensory perception of taste GO:0050909 23 19 0,000 0,11307178 0,14585816 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,11307178 0,1457764 ! smooth muscle contraction GO:0006939 36 19 0,000 0,11307178 0,14569473 ! peroxisome organization GO:0007031 29 19 0,000 0,11307178 0,14561315 ! digestive system process GO:0022600 30 19 0,000 0,11307178 0,14553167 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,11307178 0,14545028 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,11307178 0,14536897 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,11307178 0,14528776 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,11307178 0,14520664 ! response to starvation GO:0042594 30 19 0,000 0,11307178 0,14512561 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,11307178 0,14504467 ! cytolysis GO:0019835 20 19 0,000 0,11307178 0,14496382 ! vasodilation GO:0042311 33 19 0,000 0,11307178 0,14488306 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,11307178 0,14480239 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,11307178 0,14472181 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,11307178 0,14464132 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,11307178 0,14456092 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,11307178 0,14448061 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,11307178 0,14440039 ! sarcomere organization GO:0045214 23 19 0,000 0,11307178 0,14432025 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,11307178 0,14424021 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,11307178 0,14416025 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,11307178 0,14408038 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,11307178 0,14400061 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,11307178 0,14392092 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,11307178 0,14384131 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,11307178 0,1437618 ! protein stabilization GO:0050821 26 19 0,000 0,11307178 0,14368237 ! positive regulation of immune response GO:0050778 121 92 1,000 0,11419608 0,14503091 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,11624666 0,14755371 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,11865857 0,15053211 ! iron ion transport GO:0006826 37 20 0,000 0,11865857 0,15044912 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,11865857 0,15036623 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,11865857 0,15028343 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,11865857 0,15020072 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,11865857 0,1501181 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,11865857 0,15003557 ! spinal cord development GO:0021510 31 20 0,000 0,11865857 0,14995314 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,11865857 0,14987079 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,11865857 0,14978853 ! chromosome condensation GO:0030261 31 20 0,000 0,11865857 0,14970637 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,11865857 0,14962429 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,11865857 0,14954231 ! pallium development GO:0021543 38 20 0,000 0,11865857 0,14946041 ! DNA modification GO:0006304 28 20 0,000 0,11865857 0,1493786 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,11865857 0,14929689 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,11865857 0,14921526 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,11865857 0,14913372 ! collagen catabolic process GO:0030574 25 20 0,000 0,11865857 0,14905227 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,11865857 0,14897091 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,11865857 0,14888964 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,11865857 0,14880846 ! carboxylic acid transport GO:0046942 147 95 1,000 0,12037589 0,15087986 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 1,000 0,12245413 0,15340115 ! protein maturation GO:0051604 129 96 1,000 0,12245413 0,15331764 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,12421049 0,15543206 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,12421049 0,15534754 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,12421049 0,15526311 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,12421049 0,15517877 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,12421049 0,15509453 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,12421049 0,15501037 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,12421049 0,15492631 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,12421049 0,15484234 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,12421049 0,15475846 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,12421049 0,15467467 ! protein amino acid acylation GO:0043543 37 21 0,000 0,12421049 0,15459097 ! vesicle docking GO:0048278 27 21 0,000 0,12421049 0,15450736 ! phototransduction GO:0007602 25 21 0,000 0,12421049 0,15442385 ! dendrite development GO:0016358 35 21 0,000 0,12421049 0,15434042 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,12421049 0,15425708 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,12421049 0,15417384 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,12421049 0,15409068 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,12421049 0,15400761 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,12421049 0,15392463 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,12421049 0,15384174 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,12421049 0,15375894 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,12421049 0,15367623 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,12421049 0,15359361 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,12421049 0,15351108 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,12421049 0,15342863 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,12421049 0,15334628 ! fatty acid transport GO:0015908 30 21 0,000 0,12421049 0,15326401 ! immunoglobulin production GO:0002377 33 21 0,000 0,12421049 0,15318183 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,12421049 0,15309974 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,12421049 0,15301774 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,12421049 0,15293582 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,12421049 0,152854 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,12421049 0,15277226 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,12421049 0,1526906 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,12421049 0,15260904 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,12421049 0,15252756 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,12421049 0,15244617 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,12421049 0,15236486 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,12421049 0,15228364 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,12421049 0,15220251 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,12421049 0,15212147 ! protein import GO:0017038 156 99 1,000 0,12874109 0,15758622 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,12972774 0,15870947 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,12972774 0,1586251 ! viral genome replication GO:0019079 29 22 0,000 0,12972774 0,15854081 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,12972774 0,15845662 ! leukocyte adhesion GO:0007159 38 22 0,000 0,12972774 0,15837251 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,12972774 0,15828849 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,12972774 0,15820457 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,12972774 0,15812073 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,12972774 0,15803698 ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,12972774 0,15795331 ! lysosome organization GO:0007040 37 22 0,000 0,12972774 0,15786974 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,12972774 0,15778626 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,12972774 0,15770286 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,12972774 0,15761955 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,12972774 0,15753633 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,12972774 0,1574532 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,12972774 0,15737015 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,12972774 0,1572872 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,12972774 0,15720433 ! blastocyst development GO:0001824 37 22 0,000 0,12972774 0,15712154 ! neural tube closure GO:0001843 33 22 0,000 0,12972774 0,15703885 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,12972774 0,15695624 ! regulation of translation GO:0006417 151 100 1,000 0,13085352 0,15823507 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,13085352 0,15815192 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,13085352 0,15806886 ! protein localization in organelle GO:0033365 161 100 1,000 0,13085352 0,15798588 ! neuron fate commitment GO:0048663 32 23 0,000 0,13521056 0,1631607 ! embryonic pattern specification GO:0009880 31 23 0,000 0,13521056 0,16307514 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,13521056 0,16298967 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,13521056 0,16290429 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,13521056 0,162819 ! vesicle targeting GO:0006903 32 23 0,000 0,13521056 0,1627338 ! osteoblast differentiation GO:0001649 40 23 0,000 0,13521056 0,16264868 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,13521056 0,16256366 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,13521056 0,16247873 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,13521056 0,16239388 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,13521056 0,16230913 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,13521056 0,16222446 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,13521056 0,16213988 ! cell fate determination GO:0001709 45 23 0,000 0,13521056 0,16205539 ! pentose metabolic process GO:0019321 31 23 0,000 0,13521056 0,16197098 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,13521056 0,16188667 ! spermatid development GO:0007286 33 23 0,000 0,13521056 0,16180244 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,13521056 0,1617183 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,13521056 0,16163424 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,13521056 0,16155028 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,13521056 0,1614664 ! telomere organization GO:0032200 32 23 0,000 0,13521056 0,16138261 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,13521056 0,1612989 ! regulation of amine transport GO:0051952 38 23 0,000 0,13521056 0,16121529 ! liver development GO:0001889 40 23 0,000 0,13521056 0,16113175 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,14065914 0,16753808 ! initiation of viral infection GO:0019059 42 24 0,000 0,14065914 0,16745136 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,14065914 0,16736473 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,14065914 0,1672782 ! superoxide metabolic process GO:0006801 32 24 0,000 0,14065914 0,16719175 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,14065914 0,16710539 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,14065914 0,16701912 ! sperm motility GO:0030317 27 24 0,000 0,14065914 0,16693294 ! vacuole organization GO:0007033 39 24 0,000 0,14065914 0,16684684 ! receptor metabolic process GO:0043112 37 24 0,000 0,14065914 0,16676084 ! neural crest cell development GO:0014032 39 24 0,000 0,14065914 0,16667493 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,14065914 0,1665891 ! negative regulation of cell development GO:0010721 56 24 0,000 0,14065914 0,16650336 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,14065914 0,16641771 ! base-excision repair GO:0006284 31 24 0,000 0,14065914 0,16633215 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,14065914 0,16624668 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,14065914 0,16616129 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,14065914 0,16607599 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,14065914 0,16599078 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,14607371 0,17229207 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,14607371 0,17220376 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,14607371 0,17211554 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,14607371 0,17202741 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,14607371 0,17193937 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,14607371 0,17185142 ! peptide transport GO:0015833 43 25 0,000 0,14607371 0,17176356 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,14607371 0,1716758 ! phospholipid transport GO:0015914 35 25 0,000 0,14607371 0,17158812 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,14607371 0,17150053 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,14607371 0,17141303 ! detection of light stimulus GO:0009583 30 25 0,000 0,14607371 0,17132562 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,15145447 0,17754601 ! translational initiation GO:0006413 43 26 0,000 0,15145447 0,17745557 ! regulation of pH GO:0006885 36 26 0,000 0,15145447 0,17736521 ! circadian rhythm GO:0007623 42 26 0,000 0,15145447 0,17727495 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,15145447 0,17718478 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,15145447 0,1770947 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,15145447 0,17700471 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,15145447 0,17691482 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,15145447 0,17682501 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,15145447 0,1767353 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,15145447 0,17664568 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,15145447 0,17655615 ! regulation of coagulation GO:0050818 39 26 0,000 0,15145447 0,1764667 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,15680163 0,18260443 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,15680163 0,18251201 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,15680163 0,1824197 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,15680163 0,18232747 ! membrane docking GO:0022406 39 27 0,000 0,15680163 0,18223534 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,15680163 0,1821433 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,15680163 0,18205136 ! acute-phase response GO:0006953 42 27 0,000 0,15680163 0,18195951 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,15680163 0,18186775 ! myofibril assembly GO:0030239 36 27 0,000 0,15680163 0,18177608 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,15680163 0,1816845 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,15680163 0,18159302 ! natural killer cell activation GO:0030101 35 27 0,000 0,15680163 0,18150163 ! cofactor catabolic process GO:0051187 45 27 0,000 0,15680163 0,18141033 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,15680163 0,18131913 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,15680163 0,18122801 ! gene silencing GO:0016458 41 27 0,000 0,15680163 0,18113699 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,16211539 0,18718143 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,16211539 0,18708751 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,16211539 0,18699368 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,16211539 0,18689995 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,16211539 0,18680632 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,16211539 0,18671277 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,16211539 0,18661932 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,16211539 0,18652597 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,16211539 0,1864327 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,16211539 0,18633953 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,16211539 0,18624646 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,16211539 0,18615347 ! mesoderm formation GO:0001707 46 28 0,000 0,16211539 0,18606058 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,16211539 0,18596778 ! BMP signaling pathway GO:0030509 40 28 0,000 0,16211539 0,18587508 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,16211539 0,18578247 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,16211539 0,18568994 ! neural tube formation GO:0001841 41 28 0,000 0,16211539 0,18559752 ! placenta development GO:0001890 37 28 0,000 0,16211539 0,18550518 ! regulation of innate immune response GO:0045088 38 29 0,000 0,16739598 0,19145239 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,16739598 0,19135723 ! protein targeting to membrane GO:0006612 53 29 0,000 0,16739598 0,19126217 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,16739598 0,1911672 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,16739598 0,19107233 ! muscle cell development GO:0055001 38 29 0,000 0,16739598 0,19097755 ! formation of primary germ layer GO:0001704 48 29 0,000 0,16739598 0,19088287 ! telencephalon development GO:0021537 52 29 0,000 0,16739598 0,19078828 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,16739598 0,19069378 ! eye morphogenesis GO:0048592 51 29 0,000 0,16739598 0,19059938 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,16739598 0,19050507 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,17264358 0,19637994 ! organic anion transport GO:0015711 51 30 0,000 0,17264358 0,19628287 ! cholesterol transport GO:0030301 46 30 0,000 0,17264358 0,19618589 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,17264358 0,19608901 ! spliceosome assembly GO:0000245 49 30 0,000 0,17264358 0,19599222 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,17264358 0,19589553 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,17264358 0,19579894 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,17264358 0,19570243 ! ceramide metabolic process GO:0006672 43 30 0,000 0,17264358 0,19560603 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,17264358 0,19550972 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,17264358 0,1954135 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,17264358 0,19531738 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,17264358 0,19522136 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,17785841 0,20101934 ! negative regulation of secretion GO:0051048 49 31 0,000 0,17785841 0,2009206 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,17785841 0,20082197 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,17785841 0,20072343 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,17785841 0,20062499 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,17785841 0,20052664 ! segmentation GO:0035282 41 31 0,000 0,17785841 0,20042839 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,17785841 0,20033024 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,17785841 0,20023218 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,17785841 0,20013422 ! cell fate specification GO:0001708 37 31 0,000 0,17785841 0,20003636 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,17785841 0,19993859 ! RNA modification GO:0009451 40 31 0,000 0,17785841 0,19984091 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,18304067 0,20556325 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,18304067 0,20546293 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,18304067 0,2053627 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,18304067 0,20526257 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,18304067 0,20516254 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,18304067 0,20506261 ! cytokine production GO:0001816 44 32 0,000 0,18304067 0,20496278 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,18304067 0,20486304 ! vesicle localization GO:0051648 47 32 0,000 0,18304067 0,2047634 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,18819056 0,21042211 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,18819056 0,21031986 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,18819056 0,21021772 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,18819056 0,21011567 ! actomyosin structure organization GO:0031032 43 33 0,000 0,18819056 0,21001372 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,18819056 0,20991187 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,18819056 0,20981012 ! lipid homeostasis GO:0055088 55 33 0,000 0,18819056 0,20970847 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,18819056 0,20960692 ! regulation of proteolysis GO:0030162 50 33 0,000 0,18819056 0,20950546 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,18819056 0,2094041 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,18819056 0,20930284 ! mRNA catabolic process GO:0006402 48 34 0,000 0,19330827 0,21489078 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,19330827 0,21478697 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,19330827 0,21468326 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,19330827 0,21457965 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,19330827 0,21447614 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,19330827 0,21437272 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,19330827 0,21426941 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,19330827 0,2141662 ! aerobic respiration GO:0009060 47 34 0,000 0,19330827 0,21406309 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,19330827 0,21396007 ! embryonic organ development GO:0048568 45 34 0,000 0,19330827 0,21385716 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,19330827 0,21375434 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,19839402 0,21927258 ! Notch signaling pathway GO:0007219 56 35 0,000 0,19839402 0,21916726 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,19839402 0,21906205 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,19839402 0,21895693 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,19839402 0,21885192 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,19839402 0,218747 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,19839402 0,21864219 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,19839402 0,21853747 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,19839402 0,21843286 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,19839402 0,21832835 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,19839402 0,21822393 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,20344799 0,22367609 GO:0090047|positive regulation of transcription regulator activity, ! organic ether metabolic process GO:0018904 46 36 0,000 0,20344799 0,22356922 ! neural tube development GO:0021915 50 36 0,000 0,20344799 0,22346245 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,20344799 0,22335579 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,20344799 0,22324923 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,20344799 0,22314277 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,20847039 0,22854237 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,20847039 0,22843349 ! ion transmembrane transport GO:0034220 56 37 0,000 0,20847039 0,22832471 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,20847039 0,22821604 ! regulation of protein secretion GO:0050708 51 37 0,000 0,20847039 0,22810747 ! amino acid activation GO:0043038 52 37 0,000 0,20847039 0,227999 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,20847039 0,22789063 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,2134614 0,23323574 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,2134614 0,23312499 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,2134614 0,23301435 ! phagocytosis GO:0006909 60 38 0,000 0,2134614 0,23290381 ! maintenance of location in cell GO:0051651 69 38 0,000 0,2134614 0,23279337 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,21842123 0,23808949 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,21842123 0,23797671 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,21842123 0,23786403 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,21842123 0,23775146 ! chromatin remodeling GO:0006338 68 39 0,000 0,21842123 0,23763899 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,21842123 0,23752663 ! cell growth GO:0016049 61 39 0,000 0,21842123 0,23741438 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,22335007 0,24265713 ! regulation of tube size GO:0035150 60 40 0,000 0,22335007 0,24254256 GO:0050880|regulation of blood vessel size, ! inner ear development GO:0048839 57 40 0,000 0,22335007 0,2424281 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,22335007 0,24231375 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,22335007 0,24219951 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,22335007 0,24208537 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,22335007 0,24197134 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,2282481 0,24716131 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,2282481 0,247045 ! glucose transport GO:0015758 52 41 0,000 0,2282481 0,2469288 ! striated muscle contraction GO:0006941 62 41 0,000 0,2282481 0,24681271 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,2282481 0,24669672 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,2282481 0,24658085 ! biopolymer methylation GO:0043414 62 41 0,000 0,2282481 0,24646508 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,2282481 0,24634943 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,23311552 0,25148485 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,23311552 0,25136695 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,23311552 0,25124916 ! hexose transport GO:0008645 54 42 0,000 0,23311552 0,25113147 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,23311552 0,2510139 ! excretion GO:0007588 63 42 0,000 0,23311552 0,25089644 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,23311552 0,25077909 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,23311552 0,25066185 ! positive regulation of binding GO:0051099 59 43 0,000 0,23795252 0,25574336 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,23795252 0,25562391 ! tRNA processing GO:0008033 49 43 0,000 0,23795252 0,25550458 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,23795252 0,25538535 ! methylation GO:0032259 64 43 0,000 0,23795252 0,25526623 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,24275929 0,26030134 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,24275929 0,26018004 ! regulation of ion transport GO:0043269 57 44 0,000 0,24275929 0,26005886 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,24275929 0,25993779 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,24275929 0,25981683 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,24275929 0,25969598 ! RNA catabolic process GO:0006401 64 45 0,000 0,24753601 0,26468286 ! regulation of translational initiation GO:0006446 64 45 0,000 0,24753601 0,26455986 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,24753601 0,26443698 ! cell recognition GO:0008037 58 45 0,000 0,24753601 0,26431422 ! cell maturation GO:0048469 60 45 0,000 0,24753601 0,26419157 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,25228287 0,26913294 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,25228287 0,26900816 ! cell redox homeostasis GO:0045454 63 46 0,000 0,25228287 0,26888351 ! histone modification GO:0016570 68 46 0,000 0,25228287 0,26875897 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,25228287 0,26863454 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,25700006 0,27353084 ! viral infectious cycle GO:0019058 71 47 0,000 0,25700006 0,27340432 ! covalent chromatin modification GO:0016569 75 47 0,000 0,25700006 0,27327792 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,25700006 0,27315164 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,25700006 0,27302547 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,25700006 0,27289942 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,25700006 0,27277348 ! chloride transport GO:0006821 67 48 0,000 0,26168776 0,27762078 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,26168776 0,27749278 ! gastrulation GO:0007369 73 48 0,000 0,26168776 0,2773649 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,26168776 0,27723715 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,26168776 0,2771095 ! regulation of endocytosis GO:0030100 63 48 0,000 0,26168776 0,27698198 ! nuclear export GO:0051168 69 48 0,000 0,26168776 0,27685457 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,26168776 0,27672728 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,26634615 0,28152396 ! sensory perception of smell GO:0007608 61 49 0,000 0,26634615 0,28139464 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,26634615 0,28126544 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,26634615 0,28113636 ! RNA elongation GO:0006354 62 49 0,000 0,26634615 0,2810074 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,26634615 0,28087856 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,26634615 0,28074983 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,26634615 0,28062123 ! maintenance of location GO:0051235 84 49 0,000 0,26634615 0,28049274 ! regulation of actin filament length GO:0030832 72 50 0,000 0,27097541 0,28523727 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,27097541 0,28510679 ! proton transport GO:0015992 75 50 0,000 0,27097541 0,28497642 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,27097541 0,28484618 ! hydrogen transport GO:0006818 77 51 0,000 0,27557572 0,28954964 ! transition metal ion transport GO:0000041 74 52 0,000 0,28014727 0,2942186 ! regulation of cellular component size GO:0032535 74 52 0,000 0,28014727 0,29408431 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,28014727 0,29395015 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,28014727 0,29381611 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,28469023 0,29844464 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,28469023 0,29830867 ! single fertilization GO:0007338 59 53 0,000 0,28469023 0,29817283 ! cell projection assembly GO:0030031 76 53 0,000 0,28469023 0,29803711 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,28920478 0,30262557 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,28920478 0,30248795 ! exocytosis GO:0006887 74 55 0,000 0,2936911 0,30704069 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,2936911 0,30690119 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,2936911 0,30676182 ! carbohydrate transport GO:0008643 74 57 0,000 0,30257972 0,31590256 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,30257972 0,31575923 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,30257972 0,31561603 ! camera-type eye development GO:0043010 88 57 0,000 0,30257972 0,31547296 ! developmental maturation GO:0021700 75 57 0,000 0,30257972 0,31533002 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,30698237 0,3197733 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,30698237 0,31962854 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,31135748 0,3240372 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,31570522 0,32841339 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,31570522 0,32826492 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,31570522 0,32811659 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,31570522 0,32796839 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,31570522 0,32782032 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,31570522 0,32767239 ! fertilization GO:0009566 68 60 0,000 0,31570522 0,32752459 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,32002576 0,33185719 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,32002576 0,33170764 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,32002576 0,33155822 ! amine catabolic process GO:0009310 90 62 0,000 0,32431927 0,33585516 ! neurotransmitter transport GO:0006836 81 62 0,000 0,32431927 0,33570401 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,32431927 0,335553 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,32431927 0,33540212 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,32858591 0,33966184 ! appendage morphogenesis GO:0035107 93 64 0,000 0,33282585 0,34389014 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,33282585 0,34373572 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,33282585 0,34358144 ! appendage development GO:0048736 94 65 0,000 0,33703926 0,34777492 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,33703926 0,34761897 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,33703926 0,34746315 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,33703926 0,34730748 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,3412263 0,35146461 ! antigen processing and presentation GO:0019882 96 66 0,000 0,3412263 0,35130729 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,3412263 0,35115011 ! regulation of immune effector process GO:0002697 101 66 0,000 0,3412263 0,35099306 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,34538713 0,35511417 ! acute inflammatory response GO:0002526 92 68 0,000 0,34952193 0,35920484 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,34952193 0,35904441 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,34952193 0,35888412 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,34952193 0,35872398 ! inorganic anion transport GO:0015698 93 68 0,000 0,34952193 0,35856397 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,35363084 0,36261744 ! eye development GO:0001654 111 70 0,000 0,35771403 0,36664094 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,35771403 0,36647762 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,36177166 0,37046964 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,36177166 0,37030477 ! regulation of blood pressure GO:0008217 107 73 0,000 0,36981087 0,37836521 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,37379276 0,38226917 ! digestion GO:0007586 97 74 0,000 0,37379276 0,38209927 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,37379276 0,38192952 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,37774973 0,38580123 ! amine biosynthetic process GO:0009309 97 76 0,000 0,38168191 0,38964421 ! tRNA metabolic process GO:0006399 95 76 0,000 0,38168191 0,38947134 ! regulation of protein transport GO:0051223 114 76 0,000 0,38168191 0,38929862 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,38558947 0,39310983 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,38558947 0,39293566 ! protein ubiquitination GO:0016567 125 77 0,000 0,38558947 0,39276164 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,38558947 0,39258777 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,38558947 0,39241406 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,38947256 0,39619057 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,38947256 0,39601542 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,39333133 0,39976229 ! cellular respiration GO:0045333 107 79 0,000 0,39333133 0,39958571 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,39333133 0,3994093 ! regulation of lyase activity GO:0051339 133 79 0,000 0,39333133 0,39923303 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,39333133 0,39905693 ! chromatin assembly GO:0031497 102 80 0,000 0,39716593 0,40276968 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,39716593 0,40259217 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,40097651 0,40627576 ! mRNA transport GO:0051028 121 81 0,000 0,40097651 0,40609686 ! vitamin metabolic process GO:0006766 103 81 0,000 0,40097651 0,40591812 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,40097651 0,40573954 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,40852621 0,41319714 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,41226563 0,41679602 ! sterol metabolic process GO:0016125 120 84 0,000 0,41226563 0,4166129 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,41598162 0,42018346 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,41967433 0,42372737 ! nucleosome organization GO:0034728 114 87 0,000 0,4233439 0,42724483 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,4233439 0,42705744 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,4233439 0,42687022 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,42699047 0,43035849 ! establishment of RNA localization GO:0051236 128 88 0,000 0,42699047 0,43016999 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,4306142 0,43363076 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,43421521 0,43706564 ! hormone metabolic process GO:0042445 121 90 0,000 0,43421521 0,43687445 ! RNA localization GO:0006403 135 91 0,000 0,43779366 0,44028221 ! ATP metabolic process GO:0046034 137 91 0,000 0,43779366 0,44008978 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,44134967 0,44347062 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,44134967 0,44327696 ! DNA recombination GO:0006310 146 92 0,000 0,44134967 0,44308348 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,4448834 0,44643622 ! electron transport chain GO:0022900 123 94 0,000 0,44839498 0,44976382 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,45535223 0,45654321 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,45535223 0,45634428 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,45535223 0,45614553 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,45879818 0,45939739 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,45879818 0,45919748 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,46900693 0,46921093 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,46900693 0,46900693