pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6427-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 209 95 11,000 1,781E-12 4,286E-09 ! interphase GO:0051325 213 98 11,000 2,602E-12 3,13E-09 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 8,000 1,432E-10 1,149E-07 ! apoptotic mitochondrial changes GO:0008637 41 20 5,000 2,854E-09 1,716E-06 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 5,000 1,268E-08 6,103E-06 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 6,000 2,204E-08 8,836E-06 ! response to UV GO:0009411 104 53 6,000 6,102E-08 2,097E-05 ! regulation of DNA metabolic process GO:0051052 178 97 7,000 2,866E-07 8,618E-05 ! cell cycle arrest GO:0007050 213 100 7,000 3,628E-07 9,698E-05 ! meiosis GO:0007126 121 74 6,000 6,333E-07 1,524E-04 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 122 75 6,000 6,945E-07 1,519E-04 ! response to gamma radiation GO:0010332 28 14 3,000 1,793E-06 3,595E-04 ! release of cytochrome c from mitochondria GO:0001836 30 14 3,000 1,793E-06 3,319E-04 ! nucleotide-excision repair GO:0006289 83 56 5,000 1,959E-06 3,367E-04 ! regulation of DNA replication GO:0006275 101 56 5,000 1,959E-06 3,143E-04 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 2,000 2,857E-06 4,296E-04 ! response to peptide hormone stimulus GO:0043434 122 61 5,000 3,26E-06 4,614E-04 ! androgen receptor signaling pathway GO:0030521 74 36 4,000 3,917E-06 5,236E-04 ! meiosis I GO:0007127 65 37 4,000 4,505E-06 5,705E-04 ! regulation of protein stability GO:0031647 73 37 4,000 4,505E-06 5,419E-04 ! negative regulation of cell growth GO:0030308 132 67 5,000 5,668E-06 6,494E-04 ! male meiosis GO:0007140 7 6 2,000 5,686E-06 6,218E-04 ! cell cycle checkpoint GO:0000075 137 69 5,000 6,734E-06 7,045E-04 ! negative regulation of cell size GO:0045792 134 69 5,000 6,734E-06 6,751E-04 ! G1 phase GO:0051318 40 19 3,000 6,765E-06 6,511E-04 ! regulation of epithelial cell proliferation GO:0050678 111 43 4,000 9,632E-06 8,913E-04 ! centrosome duplication GO:0051298 13 7 2,000 9,901E-06 8,823E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 9,901E-06 8,508E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 9,901E-06 8,215E-04 ! reciprocal meiotic recombination GO:0007131 39 21 3,000 1,034E-05 8,291E-04 ! cell aging GO:0007569 44 21 3,000 1,034E-05 8,024E-04 ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 1,209E-05 9,093E-04 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 3,000 1,257E-05 9,164E-04 ! response to insulin stimulus GO:0032868 95 46 4,000 1,35E-05 9,551E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 2,000 1,576E-05 1,084E-03 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 1,576E-05 1,054E-03 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 1,576E-05 1,025E-03 ! positive regulation of cell cycle GO:0045787 89 48 4,000 1,668E-05 1,056E-03 ! negative regulation of growth GO:0045926 155 84 5,000 2,103E-05 1,297E-03 ! negative regulation of DNA replication GO:0008156 42 25 3,000 2,14E-05 1,287E-03 ! mitochondrion organization GO:0007005 148 86 5,000 2,405E-05 1,412E-03 ! aging GO:0007568 103 55 4,000 3,263E-05 1,869E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 3,345E-05 1,872E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 3,345E-05 1,829E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 2,000 3,345E-05 1,788E-03 ! oocyte development GO:0048599 17 10 2,000 3,345E-05 1,75E-03 ! oocyte differentiation GO:0009994 18 11 2,000 4,577E-05 2,343E-03 ! integrin-mediated signaling pathway GO:0007229 135 59 4,000 4,596E-05 2,304E-03 ! DNA damage response, signal transduction GO:0042770 128 60 4,000 4,987E-05 2,449E-03 ! response to ionizing radiation GO:0010212 65 32 3,000 5,866E-05 2,823E-03 ! regulation of B cell proliferation GO:0030888 20 12 2,000 6,073E-05 2,865E-03 ! focal adhesion formation GO:0048041 35 12 2,000 6,073E-05 2,81E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 6,073E-05 2,757E-03 GO:0042130|negative regulation of T cell proliferation, ! steroid hormone receptor signaling pathway GO:0030518 129 63 4,000 6,316E-05 2,814E-03 ! DNA damage checkpoint GO:0000077 71 33 3,000 6,641E-05 2,905E-03 ! double-strand break repair via homologous recombination GO:0000724 19 13 2,000 7,856E-05 3,375E-03 GO:0000725|recombinational repair, ! response to X-ray GO:0010165 25 13 2,000 7,856E-05 3,316E-03 ! negative regulation of DNA metabolic process GO:0051053 61 35 3,000 8,41E-05 3,489E-03 ! negative regulation of protein kinase activity GO:0006469 130 67 4,000 8,494E-05 3,464E-03 ! negative regulation of kinase activity GO:0033673 131 68 4,000 9,119E-05 3,657E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 4,000 9,119E-05 3,597E-03 ! DNA integrity checkpoint GO:0031570 75 36 3,000 9,412E-05 3,652E-03 ! cellular response to insulin stimulus GO:0032869 82 37 3,000 1,05E-04 4,009E-03 ! negative regulation of transferase activity GO:0051348 140 72 4,000 1,198E-04 4,504E-03 ! negative regulation of binding GO:0051100 72 40 3,000 1,43E-04 5,294E-03 ! G1 phase of mitotic cell cycle GO:0000080 35 16 2,000 1,516E-04 5,526E-03 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 2,000 1,516E-04 5,443E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 1,516E-04 5,363E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of T cell differentiation GO:0045580 70 41 3,000 1,577E-04 5,498E-03 ! regulation of protein binding GO:0043393 33 17 2,000 1,832E-04 6,295E-03 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 2,000 1,832E-04 6,207E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 4,000 1,859E-04 6,211E-03 ! double-strand break repair GO:0006302 81 44 3,000 2,081E-04 6,858E-03 ! centrosome cycle GO:0007098 25 18 2,000 2,187E-04 7,111E-03 ! cell-substrate junction assembly GO:0007044 54 18 2,000 2,187E-04 7,016E-03 ! branching morphogenesis of a tube GO:0048754 97 45 3,000 2,272E-04 7,193E-03 ! negative regulation of cell migration GO:0030336 115 46 3,000 2,476E-04 7,736E-03 ! regulation of ligase activity GO:0051340 142 84 4,000 2,479E-04 7,646E-03 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 2,000 2,585E-04 7,871E-03 ! activation of caspase activity GO:0006919 84 48 3,000 2,922E-04 8,786E-03 ! regulation of lymphocyte differentiation GO:0045619 81 48 3,000 2,922E-04 8,678E-03 ! regulation of mast cell proliferation GO:0070666 81 48 3,000 2,922E-04 8,572E-03 ! response to alkaloid GO:0043279 38 20 2,000 3,026E-04 8,771E-03 ! negative regulation of T cell activation GO:0050868 40 20 2,000 3,026E-04 8,667E-03 ! gland development GO:0048732 206 88 4,000 3,079E-04 8,715E-03 ! DNA-dependent DNA replication GO:0006261 74 49 3,000 3,165E-04 8,854E-03 ! regulation of cell adhesion GO:0030155 212 89 4,000 3,245E-04 8,973E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 3,513E-04 9,604E-03 ! oogenesis GO:0048477 36 21 2,000 3,513E-04 9,497E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 3,000 3,694E-04 9,876E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! morphogenesis of a branching structure GO:0001763 111 52 3,000 3,982E-04 0,01052702 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 2,000 4,048E-04 0,0105855 ! apoptotic nuclear changes GO:0030262 32 22 2,000 4,048E-04 0,01047168 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 2,000 4,048E-04 0,01036028 ! protein stabilization GO:0050821 39 22 2,000 4,048E-04 0,01025122 ! cell maturation GO:0048469 100 53 3,000 4,284E-04 0,01073766 ! negative regulation of protein ubiquitination GO:0031397 9 5 1,000 4,331E-04 0,01074181 ! negative regulation of cell-cell adhesion GO:0022408 12 5 1,000 4,331E-04 0,0106322 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 1,000 4,331E-04 0,01052481 ! skeletal myofibril assembly GO:0014866 10 5 1,000 4,331E-04 0,01041956 ! cardiac muscle fiber development GO:0048739 10 5 1,000 4,331E-04 0,0103164 ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 4,331E-04 0,01021525 ! microvillus organization GO:0032528 7 5 1,000 4,331E-04 0,01011608 GO:0030033|microvillus assembly, ! regulation of response to food GO:0032095 7 5 1,000 4,331E-04 0,01001881 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 4,331E-04 9,923E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 4,331E-04 9,83E-03 ! early endosome to late endosome transport GO:0045022 12 5 1,000 4,331E-04 9,738E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 4,331E-04 9,648E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 4,331E-04 9,559E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 4,331E-04 9,472E-03 ! mitotic recombination GO:0006312 9 5 1,000 4,331E-04 9,387E-03 ! regulation of sterol transport GO:0032371 7 5 1,000 4,331E-04 9,303E-03 GO:0032374|regulation of cholesterol transport, ! B cell homeostasis GO:0001782 13 5 1,000 4,331E-04 9,221E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 4,331E-04 9,14E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 4,331E-04 9,06E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 4,331E-04 8,982E-03 ! receptor biosynthetic process GO:0032800 7 5 1,000 4,331E-04 8,906E-03 ! stem cell division GO:0017145 11 5 1,000 4,331E-04 8,83E-03 GO:0048103|somatic stem cell division, ! leukocyte differentiation GO:0002521 202 96 4,000 4,602E-04 9,306E-03 ! myeloid leukocyte differentiation GO:0002573 40 23 2,000 4,632E-04 9,287E-03 ! regulation of cell-matrix adhesion GO:0001952 78 23 2,000 4,632E-04 9,211E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 4,632E-04 9,135E-03 ! positive regulation of caspase activity GO:0043280 95 55 3,000 4,939E-04 9,661E-03 GO:0010952|positive regulation of peptidase activity, ! negative regulation of cell motion GO:0051271 134 55 3,000 4,939E-04 9,583E-03 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 2,000 5,268E-04 0,01013987 ! negative regulation of phosphorylation GO:0042326 47 24 2,000 5,268E-04 0,0100594 ! positive regulation of cell migration GO:0030335 126 57 3,000 5,661E-04 0,01072503 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 2,000 5,957E-04 0,01119767 ! receptor metabolic process GO:0043112 46 25 2,000 5,957E-04 0,01111087 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 5,957E-04 0,0110254 ! DNA catabolic process GO:0006308 86 59 3,000 6,456E-04 0,01185681 ! positive regulation of actin filament polymerization GO:0030838 11 6 1,000 6,468E-04 0,01178859 ! embryonic hemopoiesis GO:0035162 14 6 1,000 6,468E-04 0,01169996 ! activation of MAPKKK activity GO:0000185 12 6 1,000 6,468E-04 0,01161264 ! regulation of appetite GO:0032098 9 6 1,000 6,468E-04 0,01152662 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 6,468E-04 0,01144187 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of spindle localization GO:0051293 12 6 1,000 6,468E-04 0,01135835 GO:0051653|spindle localization, ! monocyte differentiation GO:0030224 12 6 1,000 6,468E-04 0,01127604 ! neural nucleus development GO:0048857 14 6 1,000 6,468E-04 0,01119492 ! response to UV-C GO:0010225 11 6 1,000 6,468E-04 0,01111496 ! enucleate erythrocyte differentiation GO:0043353 12 6 1,000 6,468E-04 0,01103613 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 6,468E-04 0,01095841 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 6,468E-04 0,01088178 GO:0043011|myeloid dendritic cell differentiation, ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 6,468E-04 0,01080621 ! cytoplasmic microtubule organization GO:0031122 14 6 1,000 6,468E-04 0,01073168 ! negative regulation of B cell activation GO:0050869 13 6 1,000 6,468E-04 0,01065818 ! microtubule organizing center organization GO:0031023 39 26 2,000 6,701E-04 0,01096842 GO:0051297|centrosome organization, ! insulin receptor signaling pathway GO:0008286 64 26 2,000 6,701E-04 0,01089431 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 2,000 6,701E-04 0,0108212 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 44 26 2,000 6,701E-04 0,01074905 ! protein amino acid autophosphorylation GO:0046777 141 60 3,000 6,881E-04 0,01096435 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 7,502E-04 0,01187543 ! fat cell differentiation GO:0045444 50 27 2,000 7,502E-04 0,01179782 ! mitochondrial membrane organization GO:0007006 57 27 2,000 7,502E-04 0,01172121 ! base-excision repair GO:0006284 41 27 2,000 7,502E-04 0,01164559 ! regulation of chromosome organization GO:0033044 42 27 2,000 7,502E-04 0,01157094 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 7,502E-04 0,01149724 ! regulation of lipid metabolic process GO:0019216 115 63 3,000 8,276E-04 0,01260333 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 8,362E-04 0,01265301 ! positive regulation of cell motion GO:0051272 146 64 3,000 8,783E-04 0,01320719 ! regulation of helicase activity GO:0051095 15 7 1,000 9,015E-04 0,01347207 ! cytokinesis during cell cycle GO:0033205 11 7 1,000 9,015E-04 0,01338891 ! regulation of lipid kinase activity GO:0043550 13 7 1,000 9,015E-04 0,01330677 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 9,015E-04 0,01322563 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 9,015E-04 0,01314547 ! response to dietary excess GO:0002021 8 7 1,000 9,015E-04 0,01306628 ! positive regulation of mitotic cell cycle GO:0045931 12 7 1,000 9,015E-04 0,01298804 ! eating behavior GO:0042755 7 7 1,000 9,015E-04 0,01291073 ! prostate gland development GO:0030850 13 7 1,000 9,015E-04 0,01283434 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 9,015E-04 0,01275884 ! regulation of gluconeogenesis GO:0006111 7 7 1,000 9,015E-04 0,01268423 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 9,015E-04 0,01261048 ! lipoprotein transport GO:0042953 14 7 1,000 9,015E-04 0,01253759 ! organ growth GO:0035265 15 7 1,000 9,015E-04 0,01246553 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 9,015E-04 0,0123943 ! regulation of lipid transport GO:0032368 14 7 1,000 9,015E-04 0,01232388 ! response to tumor cell GO:0002347 13 7 1,000 9,015E-04 0,01225425 ! peptidyl-threonine modification GO:0018210 25 7 1,000 9,015E-04 0,01218541 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 9,015E-04 0,01211733 ! adult feeding behavior GO:0008343 9 7 1,000 9,015E-04 0,01205002 ! response to organic cyclic substance GO:0014070 55 29 2,000 9,281E-04 0,01233722 ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 9,281E-04 0,01226943 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 2,000 9,281E-04 0,01220239 ! tissue homeostasis GO:0001894 48 29 2,000 9,281E-04 0,01213607 GO:0048871|multicellular organismal homeostasis, ! myeloid cell differentiation GO:0030099 111 65 3,000 9,311E-04 0,01210882 ! actin filament organization GO:0007015 148 66 3,000 9,86E-04 0,01275479 ! developmental maturation GO:0021700 116 66 3,000 9,86E-04 0,01268658 ! cell junction assembly GO:0034329 78 30 2,000 1,026E-03 0,01313338 ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 1,026E-03 0,01306389 ! regulation of B cell activation GO:0050864 50 30 2,000 1,026E-03 0,01299514 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 3,000 1,103E-03 0,01389114 ! negative regulation of transcription regulator activity GO:0090048 58 31 2,000 1,131E-03 0,01416833 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 3,000 1,165E-03 0,01451815 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 1,197E-03 0,01484207 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 1,197E-03 0,01476595 ! regulation of response to extracellular stimulus GO:0032104 13 8 1,000 1,197E-03 0,01469062 GO:0032107|regulation of response to nutrient levels, ! pigment granule organization GO:0048753 16 8 1,000 1,197E-03 0,01461605 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,197E-03 0,01454223 ! ER overload response GO:0006983 12 8 1,000 1,197E-03 0,01446915 ! regulation of pigmentation during development GO:0048070 24 8 1,000 1,197E-03 0,01439681 ! melanin metabolic process GO:0006582 15 8 1,000 1,197E-03 0,01432518 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,197E-03 0,01425426 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 1,000 1,197E-03 0,01418404 ! response to UV-B GO:0010224 16 8 1,000 1,197E-03 0,01411451 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 1,000 1,197E-03 0,01404566 ! regulation of fat cell differentiation GO:0045598 15 8 1,000 1,197E-03 0,01397748 ! blastocyst growth GO:0001832 19 8 1,000 1,197E-03 0,01390996 ! reproductive structure development GO:0048608 113 71 3,000 1,295E-03 0,01498538 ! negative regulation of protein transport GO:0051224 69 33 2,000 1,359E-03 0,01564529 ! regulation of caspase activity GO:0043281 122 72 3,000 1,365E-03 0,01563502 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 3,000 1,365E-03 0,01556092 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 3,000 1,365E-03 0,01548752 ! regulation of transcription factor activity GO:0051090 126 74 3,000 1,511E-03 0,0170637 GO:0090046|regulation of transcription regulator activity, ! regulation of endopeptidase activity GO:0052548 125 74 3,000 1,511E-03 0,01698397 ! elastic fiber assembly GO:0048251 15 9 1,000 1,532E-03 0,01714354 ! microtubule bundle formation GO:0001578 21 9 1,000 1,532E-03 0,01706417 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,532E-03 0,01698553 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 1,000 1,532E-03 0,01690762 ! T cell selection GO:0045058 23 9 1,000 1,532E-03 0,01683041 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 1,000 1,532E-03 0,01675391 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 1,000 1,532E-03 0,0166781 ! receptor clustering GO:0043113 18 9 1,000 1,532E-03 0,01660297 ! behavioral fear response GO:0001662 22 9 1,000 1,532E-03 0,01652852 GO:0002209|behavioral defense response, ! motor axon guidance GO:0008045 16 9 1,000 1,532E-03 0,01645473 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 1,532E-03 0,0163816 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 1,532E-03 0,01630912 ! regulation of macrophage differentiation GO:0045649 15 9 1,000 1,532E-03 0,01623727 ! regulation of telomere maintenance GO:0032204 14 9 1,000 1,532E-03 0,01616605 ! cell-matrix adhesion GO:0007160 163 75 3,000 1,588E-03 0,01667957 ! negative regulation of cell adhesion GO:0007162 81 35 2,000 1,614E-03 0,01688906 ! female gonad development GO:0008585 58 35 2,000 1,614E-03 0,01681595 ! regulation of microtubule-based process GO:0032886 78 35 2,000 1,614E-03 0,01674347 ! positive regulation of ligase activity GO:0051351 124 77 3,000 1,749E-03 0,01806525 ! cell junction organization GO:0034330 86 36 2,000 1,753E-03 0,01802151 ! negative regulation of cell activation GO:0050866 65 36 2,000 1,753E-03 0,01794482 ! negative regulation of DNA binding GO:0043392 68 37 2,000 1,898E-03 0,01935101 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 1,907E-03 0,01935529 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 1,000 1,907E-03 0,01927397 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 1,000 1,907E-03 0,01919333 ! B cell proliferation GO:0042100 18 10 1,000 1,907E-03 0,01911335 ! multicellular organism growth GO:0035264 18 10 1,000 1,907E-03 0,01903405 ! epithelial cell development GO:0002064 20 10 1,000 1,907E-03 0,01895539 ! alpha-beta T cell activation GO:0046631 23 10 1,000 1,907E-03 0,01887739 ! response to nicotine GO:0035094 20 10 1,000 1,907E-03 0,01880002 ! localization within membrane GO:0051668 20 10 1,000 1,907E-03 0,01872329 ! regulation of peptidase activity GO:0052547 134 79 3,000 1,922E-03 0,01880294 ! carbohydrate homeostasis GO:0033500 53 38 2,000 2,051E-03 0,01997656 GO:0042593|glucose homeostasis, ! development of primary female sexual characteristics GO:0046545 67 38 2,000 2,051E-03 0,019896 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 67 38 2,000 2,051E-03 0,0198161 ! cell-substrate adhesion GO:0031589 171 81 3,000 2,107E-03 0,02027804 ! response to drug GO:0042493 143 82 3,000 2,204E-03 0,02112416 ! response to nutrient GO:0007584 125 82 3,000 2,204E-03 0,02104033 ! cellular response to hormone stimulus GO:0032870 167 82 3,000 2,204E-03 0,02095717 ! mammary gland development GO:0030879 86 39 2,000 2,211E-03 0,02094272 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 2,32E-03 0,02189064 ! detection of mechanical stimulus GO:0050982 22 11 1,000 2,32E-03 0,02180513 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 1,000 2,32E-03 0,02172028 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 2,32E-03 0,0216361 ! regulation of intracellular pH GO:0051453 19 11 1,000 2,32E-03 0,02155256 ! negative regulation of ossification GO:0030279 26 11 1,000 2,32E-03 0,02146966 ! DNA methylation GO:0006306 19 11 1,000 2,32E-03 0,0213874 GO:0006305|DNA alkylation, ! thymus development GO:0048538 27 11 1,000 2,32E-03 0,02130577 ! cytokinesis GO:0000910 72 40 2,000 2,379E-03 0,02175991 ! regulation of T cell proliferation GO:0042129 71 41 2,000 2,554E-03 0,02327543 ! T cell differentiation GO:0030217 81 41 2,000 2,554E-03 0,02318759 ! female gamete generation GO:0007292 61 41 2,000 2,554E-03 0,02310042 ! tube morphogenesis GO:0035239 176 86 3,000 2,621E-03 0,02361984 ! response to reactive oxygen species GO:0000302 67 42 2,000 2,737E-03 0,024572 ! regulation of intracellular protein transport GO:0033157 80 42 2,000 2,737E-03 0,02448066 ! regulation of myeloid cell differentiation GO:0045637 98 42 2,000 2,737E-03 0,02438999 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 2,772E-03 0,02461001 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 1,000 2,772E-03 0,02451954 ! fear response GO:0042596 26 12 1,000 2,772E-03 0,02442972 ! histone acetylation GO:0016573 26 12 1,000 2,772E-03 0,02434056 ! mRNA polyadenylation GO:0006378 23 12 1,000 2,772E-03 0,02425205 ! gland morphogenesis GO:0022612 29 12 1,000 2,772E-03 0,02416418 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,772E-03 0,02407694 ! T cell homeostasis GO:0043029 25 12 1,000 2,772E-03 0,02399034 ! spleen development GO:0048536 22 12 1,000 2,772E-03 0,02390435 ! digestive tract morphogenesis GO:0048546 26 12 1,000 2,772E-03 0,02381898 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of steroid biosynthetic process GO:0050810 17 12 1,000 2,772E-03 0,02373421 ! regulation of DNA binding GO:0051101 155 88 3,000 2,849E-03 0,02430663 ! epithelial cell differentiation GO:0030855 79 43 2,000 2,928E-03 0,02489357 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 2,000 2,928E-03 0,02480592 ! striated muscle cell differentiation GO:0051146 82 43 2,000 2,928E-03 0,02471888 ! ossification GO:0001503 188 90 3,000 3,09E-03 0,02599358 ! regulation of cell cycle process GO:0010564 149 90 3,000 3,09E-03 0,02590301 ! B cell differentiation GO:0030183 107 44 2,000 3,127E-03 0,02612405 ! developmental growth GO:0048589 82 44 2,000 3,127E-03 0,02603366 ! bone development GO:0060348 189 91 3,000 3,215E-03 0,02667648 ! regulation of cell-cell adhesion GO:0022407 33 13 1,000 3,262E-03 0,02696753 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 3,262E-03 0,02687517 ! Golgi organization GO:0007030 24 13 1,000 3,262E-03 0,02678345 ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 3,262E-03 0,02669235 ! regulation of cellular pH GO:0030641 22 13 1,000 3,262E-03 0,02660187 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 3,262E-03 0,02651199 ! regulation of fatty acid oxidation GO:0046320 27 13 1,000 3,262E-03 0,02642273 ! mRNA 3'-end processing GO:0031124 24 13 1,000 3,262E-03 0,02633406 ! positive regulation of protein polymerization GO:0032273 25 13 1,000 3,262E-03 0,02624599 ! cytoplasmic sequestering of protein GO:0051220 24 13 1,000 3,262E-03 0,0261585 ! cell growth GO:0016049 84 45 2,000 3,334E-03 0,02665145 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 3,000 3,477E-03 0,02769897 GO:0010498|proteasomal protein catabolic process, ! positive regulation of MAP kinase activity GO:0043406 160 93 3,000 3,477E-03 0,02760756 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 2,000 3,55E-03 0,0280928 ! pigmentation GO:0043473 100 46 2,000 3,55E-03 0,0280007 ! transcription initiation GO:0006352 153 94 3,000 3,613E-03 0,02840588 ! regulation of T cell activation GO:0050863 158 94 3,000 3,613E-03 0,02831335 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 3,789E-03 0,02959603 ! regulation of S phase GO:0033261 23 14 1,000 3,789E-03 0,02950025 ! hair follicle morphogenesis GO:0031069 26 14 1,000 3,789E-03 0,02940509 ! RNA polyadenylation GO:0043631 30 14 1,000 3,789E-03 0,02931054 ! palate development GO:0060021 31 14 1,000 3,789E-03 0,0292166 ! regulation of mRNA processing GO:0050684 24 14 1,000 3,789E-03 0,02912325 ! actin cytoskeleton reorganization GO:0031532 33 14 1,000 3,789E-03 0,0290305 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 3,789E-03 0,02893834 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 31 14 1,000 3,789E-03 0,02884677 ! mitochondrial transport GO:0006839 82 48 2,000 4,005E-03 0,03039969 ! cellular component disassembly GO:0022411 86 48 2,000 4,005E-03 0,03030409 ! regulation of protein localization GO:0032880 176 97 3,000 4,042E-03 0,0304872 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 4,353E-03 0,03272552 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 4,353E-03 0,03262357 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 4,353E-03 0,03252225 ! G1/S transition checkpoint GO:0031575 40 15 1,000 4,353E-03 0,03242156 ! intermediate filament cytoskeleton organization GO:0045104 31 15 1,000 4,353E-03 0,0323215 ! lymphocyte homeostasis GO:0002260 30 15 1,000 4,353E-03 0,03222205 ! negative regulation of immune system process GO:0002683 95 50 2,000 4,495E-03 0,0331749 ! response to estrogen stimulus GO:0043627 93 51 2,000 4,753E-03 0,03497066 ! regulation of protein ubiquitination GO:0031396 25 16 1,000 4,953E-03 0,03632954 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 4,953E-03 0,03621912 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 4,953E-03 0,03610936 ! activation of MAPKK activity GO:0000186 35 16 1,000 4,953E-03 0,03600027 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 4,953E-03 0,03589184 GO:0031114|regulation of microtubule depolymerization, ! intermediate filament-based process GO:0045103 32 16 1,000 4,953E-03 0,03578406 ! axon cargo transport GO:0008088 43 16 1,000 4,953E-03 0,03567692 ! positive regulation of protein import into nucleus GO:0042307 30 16 1,000 4,953E-03 0,03557042 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 4,953E-03 0,03546455 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 4,953E-03 0,03535932 ! defense response to virus GO:0051607 37 16 1,000 4,953E-03 0,03525471 ! regulation of neuron apoptosis GO:0043523 100 53 2,000 5,295E-03 0,03758007 ! positive regulation of protein complex assembly GO:0031334 32 17 1,000 5,589E-03 0,03954749 ! metencephalon development GO:0022037 30 17 1,000 5,589E-03 0,03943151 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 5,589E-03 0,03931622 ! signal complex assembly GO:0007172 41 17 1,000 5,589E-03 0,03920159 ! endothelial cell migration GO:0043542 28 17 1,000 5,589E-03 0,03908763 ! regulation of viral genome replication GO:0045069 28 17 1,000 5,589E-03 0,03897434 ! regulation of survival gene product expression GO:0045884 33 17 1,000 5,589E-03 0,03886169 ! cardiac muscle tissue development GO:0048738 31 17 1,000 5,589E-03 0,0387497 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 5,589E-03 0,03863835 ! negative regulation of protein catabolic process GO:0042177 40 17 1,000 5,589E-03 0,03852764 ! DNA unwinding during replication GO:0006268 27 17 1,000 5,589E-03 0,03841756 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 5,589E-03 0,03830811 ! RNA 3'-end processing GO:0031123 34 17 1,000 5,589E-03 0,03819928 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 5,589E-03 0,03809107 ! regulation of protein catabolic process GO:0042176 116 55 2,000 5,873E-03 0,03991466 ! regulation of multicellular organism growth GO:0040014 85 55 2,000 5,873E-03 0,03980222 ! positive regulation of organelle organization GO:0010638 100 56 2,000 6,175E-03 0,04173463 ! regulation of lipid biosynthetic process GO:0046890 25 18 1,000 6,26E-03 0,04218806 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 6,26E-03 0,04207021 ! patterning of blood vessels GO:0001569 39 18 1,000 6,26E-03 0,04195303 ! epidermis morphogenesis GO:0048730 40 18 1,000 6,26E-03 0,04183649 ! peptidyl-serine phosphorylation GO:0018105 38 18 1,000 6,26E-03 0,0417206 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 1,000 6,26E-03 0,04160535 ! regulation of steroid metabolic process GO:0019218 30 18 1,000 6,26E-03 0,04149073 ! long-chain fatty acid transport GO:0015909 31 18 1,000 6,26E-03 0,04137675 ! regulation of intracellular transport GO:0032386 101 57 2,000 6,487E-03 0,04275966 ! lipid phosphorylation GO:0046834 35 19 1,000 6,966E-03 0,04579202 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 6,966E-03 0,04566724 ! bile acid metabolic process GO:0008206 29 19 1,000 6,966E-03 0,04554315 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 1,000 6,966E-03 0,04541972 ! cellular response to unfolded protein GO:0034620 33 19 1,000 6,966E-03 0,04529697 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 42 19 1,000 6,966E-03 0,04517487 ! neuromuscular junction development GO:0007528 34 19 1,000 6,966E-03 0,04505343 ! cellular pigmentation GO:0033059 36 19 1,000 6,966E-03 0,04493265 ! skeletal system morphogenesis GO:0048705 105 59 2,000 7,138E-03 0,04591829 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 1,000 7,706E-03 0,04944319 ! protein amino acid acetylation GO:0006473 39 20 1,000 7,706E-03 0,04931169 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 7,706E-03 0,04918089 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 7,706E-03 0,04905079 GO:0010675|regulation of cellular carbohydrate metabolic process, ! DNA duplex unwinding GO:0032508 31 20 1,000 7,706E-03 0,04892136 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 1,000 7,706E-03 0,04879262 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 7,706E-03 0,04866456 ! regulation of fatty acid metabolic process GO:0019217 38 20 1,000 7,706E-03 0,04853717 ! peptidyl-serine modification GO:0018209 43 20 1,000 7,706E-03 0,04841044 ! negative regulation of translation GO:0017148 29 20 1,000 7,706E-03 0,04828437 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 7,706E-03 0,04815895 ! ear development GO:0043583 103 62 2,000 8,184E-03 0,05101461 ! gonad development GO:0008406 98 62 2,000 8,184E-03 0,05088279 ! regulation of homeostatic process GO:0032844 134 62 2,000 8,184E-03 0,05075165 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 1,000 8,48E-03 0,05245227 ! ovarian follicle development GO:0001541 35 21 1,000 8,48E-03 0,05231778 ! smooth muscle contraction GO:0006939 46 21 1,000 8,48E-03 0,05218398 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 1,000 8,48E-03 0,05205085 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 1,000 8,48E-03 0,05191841 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 1,000 8,48E-03 0,05178664 ! cholesterol biosynthetic process GO:0006695 37 21 1,000 8,48E-03 0,05165553 ! DNA modification GO:0006304 34 21 1,000 8,48E-03 0,05152509 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 8,48E-03 0,0513953 ! response to cytokine stimulus GO:0034097 63 21 1,000 8,48E-03 0,05126617 ! gut development GO:0048565 39 21 1,000 8,48E-03 0,05113768 ! positive regulation of protein catabolic process GO:0045732 38 22 1,000 9,288E-03 0,05586735 ! microtubule-based transport GO:0010970 54 22 1,000 9,288E-03 0,05572803 ! regeneration GO:0031099 41 22 1,000 9,288E-03 0,05558941 ! central nervous system neuron development GO:0021954 46 22 1,000 9,288E-03 0,05545147 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 9,288E-03 0,05531421 ! positive regulation of cytoskeleton organization GO:0051495 48 22 1,000 9,288E-03 0,05517763 ! ureteric bud development GO:0001657 43 22 1,000 9,288E-03 0,05504173 ! renal system process GO:0003014 41 22 1,000 9,288E-03 0,05490649 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 9,288E-03 0,05477192 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 9,288E-03 0,054638 ! positive regulation of B cell activation GO:0050871 38 22 1,000 9,288E-03 0,05450474 ! activation of JUN kinase activity GO:0007257 42 22 1,000 9,288E-03 0,05437212 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 9,288E-03 0,05424015 ! germ cell development GO:0007281 118 65 2,000 9,317E-03 0,05427575 ! extracellular matrix organization GO:0030198 133 66 2,000 9,713E-03 0,05645009 ! lung development GO:0030324 144 67 2,000 0,01011977 0,05867027 ! homeostasis of number of cells GO:0048872 114 67 2,000 0,01011977 0,05852924 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 0,01012846 0,05843904 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 1,000 0,01012846 0,05829924 ! response to ethanol GO:0045471 46 23 1,000 0,01012846 0,0581601 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 0,01012846 0,05802162 ! regulation of viral reproduction GO:0050792 38 23 1,000 0,01012846 0,0578838 ! fatty acid transport GO:0015908 44 23 1,000 0,01012846 0,05774664 ! negative regulation of catabolic process GO:0009895 50 23 1,000 0,01012846 0,05761012 ! negative regulation of ligase activity GO:0051352 112 68 2,000 0,01053594 0,05978648 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! urogenital system development GO:0001655 137 69 2,000 0,01096191 0,0620573 ! protein import into nucleus, translocation GO:0000060 46 24 1,000 0,01100134 0,06213433 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 0,01100134 0,06198882 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 1,000 0,01100134 0,06184398 ! multicellular organismal response to stress GO:0033555 49 24 1,000 0,01100134 0,06169983 ! central nervous system neuron differentiation GO:0021953 50 24 1,000 0,01100134 0,06155634 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 0,01100134 0,06141352 ! regulation of alpha-beta T cell activation GO:0046634 42 24 1,000 0,01100134 0,06127136 ! lymphocyte proliferation GO:0046651 48 24 1,000 0,01100134 0,06112985 ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 0,01100134 0,060989 ! leukocyte homeostasis GO:0001776 44 24 1,000 0,01100134 0,06084879 ! protein tetramerization GO:0051262 52 24 1,000 0,01100134 0,06070923 ! respiratory tube development GO:0030323 150 70 2,000 0,01139772 0,06275266 ! B cell activation GO:0042113 160 71 2,000 0,01184341 0,06505761 ! myelination GO:0042552 45 25 1,000 0,01190618 0,06525344 ! vasculogenesis GO:0001570 46 25 1,000 0,01190618 0,06510514 ! response to starvation GO:0042594 42 25 1,000 0,01190618 0,06495751 ! osteoblast differentiation GO:0001649 60 25 1,000 0,01190618 0,06481055 ! negative regulation of cell development GO:0010721 73 25 1,000 0,01190618 0,06466425 GO:0050768|negative regulation of neurogenesis, ! regulation of insulin secretion GO:0050796 37 25 1,000 0,01190618 0,06451861 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 1,000 0,01190618 0,06437362 ! somitogenesis GO:0001756 43 25 1,000 0,01190618 0,06422929 ! cellular response to nutrient levels GO:0031669 41 25 1,000 0,01190618 0,0640856 ! respiratory system development GO:0060541 153 72 2,000 0,012299 0,06605224 ! molting cycle process GO:0022404 50 26 1,000 0,01284251 0,06881757 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of transcription factor import into nucleus GO:0042990 54 26 1,000 0,01284251 0,06866464 ! cellular response to oxidative stress GO:0034599 39 26 1,000 0,01284251 0,06851239 ! positive regulation of nuclear division GO:0051785 40 26 1,000 0,01284251 0,06836081 GO:0045840|positive regulation of mitosis, ! blastocyst development GO:0001824 49 26 1,000 0,01284251 0,06820991 ! leukocyte proliferation GO:0070661 52 26 1,000 0,01284251 0,06805966 GO:0032943|mononuclear cell proliferation, ! positive regulation of JUN kinase activity GO:0043507 51 26 1,000 0,01284251 0,06791008 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 0,01372559 0,07242052 ! lymphocyte differentiation GO:0030098 167 75 2,000 0,01372559 0,07226205 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 0,0138099 0,07254718 ! spliceosomal snRNP biogenesis GO:0000387 36 27 1,000 0,0138099 0,07238913 ! protein amino acid acylation GO:0043543 55 27 1,000 0,0138099 0,07223176 ! male gonad development GO:0008584 44 27 1,000 0,0138099 0,07207507 ! response to toxin GO:0009636 47 27 1,000 0,0138099 0,07191907 ! development of primary sexual characteristics GO:0045137 124 76 2,000 0,01422114 0,07390077 ! regulation of catabolic process GO:0009894 161 76 2,000 0,01422114 0,0737415 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 0,01472675 0,07619904 ! dendrite development GO:0016358 59 28 1,000 0,01480787 0,07645439 ! negative regulation of protein modification process GO:0031400 60 28 1,000 0,01480787 0,07629068 ! positive regulation of T cell differentiation GO:0045582 42 28 1,000 0,01480787 0,07612766 ! regulation of JUN kinase activity GO:0043506 58 28 1,000 0,01480787 0,07596534 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 2,000 0,01524243 0,07802829 ! negative regulation of organelle organization GO:0010639 161 78 2,000 0,01524243 0,07786262 ! response to steroid hormone stimulus GO:0048545 137 78 2,000 0,01524243 0,07769766 ! protein oligomerization GO:0051259 139 78 2,000 0,01524243 0,07753339 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 2,000 0,01576822 0,08003869 ! activation of protein kinase activity GO:0032147 147 79 2,000 0,01576822 0,07987019 ! positive regulation of phosphorylation GO:0042327 129 79 2,000 0,01576822 0,07970239 ! regulation of pH GO:0006885 43 29 1,000 0,01583601 0,07987721 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 0,01583601 0,0797101 ! regulation of peptide secretion GO:0002791 47 29 1,000 0,01583601 0,07954369 ! sterol biosynthetic process GO:0016126 52 29 1,000 0,01583601 0,07937798 ! negative regulation of neuron apoptosis GO:0043524 56 29 1,000 0,01583601 0,07921295 ! response to metal ion GO:0010038 140 80 2,000 0,01630413 0,08138533 ! muscle cell differentiation GO:0042692 159 80 2,000 0,01630413 0,08121683 ! T cell activation GO:0042110 168 81 2,000 0,01685017 0,08376344 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 2,000 0,01685017 0,08359073 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 171 81 2,000 0,01685017 0,08341874 ! myofibril assembly GO:0030239 47 30 1,000 0,01689385 0,08346324 GO:0055002|striated muscle cell development, ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 0,01689385 0,08329221 ! ensheathment of neurons GO:0007272 57 30 1,000 0,01689385 0,08312187 GO:0008366|axon ensheathment, ! response to heat GO:0009408 50 30 1,000 0,01689385 0,08295224 ! cholesterol metabolic process GO:0008203 136 82 2,000 0,01740636 0,08529472 ! response to oxygen levels GO:0070482 176 83 2,000 0,01797272 0,087891 ! ovulation cycle process GO:0022602 49 31 1,000 0,01798097 0,08775295 ! iron ion homeostasis GO:0055072 54 31 1,000 0,01798097 0,08757531 ! erythrocyte differentiation GO:0030218 55 31 1,000 0,01798097 0,08739839 ! myeloid leukocyte activation GO:0002274 49 31 1,000 0,01798097 0,08722218 ! negative regulation of transport GO:0051051 153 84 2,000 0,01854926 0,08979782 ! response to hydrogen peroxide GO:0042542 50 32 1,000 0,01909693 0,09226347 ! negative regulation of response to external stimulus GO:0032102 47 32 1,000 0,01909693 0,09207857 ! spindle organization GO:0007051 46 32 1,000 0,01909693 0,09189441 ! metanephros development GO:0001656 74 32 1,000 0,01909693 0,09171099 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,01909693 0,0915283 ! regulation of protein import into nucleus GO:0042306 63 32 1,000 0,01909693 0,09134634 ! muscle cell development GO:0055001 49 32 1,000 0,01909693 0,09116509 ! ovulation cycle GO:0042698 51 32 1,000 0,01909693 0,09098457 ! peripheral nervous system development GO:0007422 64 32 1,000 0,01909693 0,09080476 ! hindbrain development GO:0030902 61 32 1,000 0,01909693 0,09062565 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 1,000 0,01909693 0,09044726 ! positive regulation of catabolic process GO:0009896 64 32 1,000 0,01909693 0,09026956 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,01913598 0,09027682 GO:0002696|positive regulation of leukocyte activation, ! response to inorganic substance GO:0010035 153 86 2,000 0,01973291 0,09291071 ! post-embryonic development GO:0009791 69 33 1,000 0,02024131 0,09511833 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,02024131 0,09493291 ! regulation of protein transport GO:0051223 154 87 2,000 0,02034003 0,09521034 GO:0070201|regulation of establishment of protein localization, ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,02141368 0,10004139 ! placenta development GO:0001890 53 34 1,000 0,02141368 0,09984751 ! sex differentiation GO:0007548 145 90 2,000 0,02222267 0,10341925 ! regulation of muscle development GO:0048634 70 35 1,000 0,02261363 0,10503551 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,02261363 0,10483313 ! odontogenesis GO:0042476 66 35 1,000 0,02261363 0,10463153 ! embryonic skeletal system morphogenesis GO:0048704 59 35 1,000 0,02261363 0,1044307 ! negative regulation of hydrolase activity GO:0051346 62 35 1,000 0,02261363 0,10423064 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,02261363 0,10403135 ! sterol metabolic process GO:0016125 152 91 2,000 0,02287065 0,10501294 ! response to protein stimulus GO:0051789 149 91 2,000 0,02287065 0,10481292 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,02384074 0,10905101 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 1,000 0,02384074 0,10884408 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! maintenance of protein location in cell GO:0032507 86 36 1,000 0,02384074 0,10863793 ! positive regulation of cell development GO:0010720 80 36 1,000 0,02384074 0,10843257 ! embryonic organ development GO:0048568 57 36 1,000 0,02384074 0,10822798 ! regulation of membrane potential GO:0042391 164 93 2,000 0,02419724 0,10963948 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 1,000 0,02509461 0,11349178 ! sister chromatid segregation GO:0000819 58 37 1,000 0,02509461 0,11327885 ! actomyosin structure organization GO:0031032 62 37 1,000 0,02509461 0,11306672 ! monovalent inorganic cation homeostasis GO:0055067 58 37 1,000 0,02509461 0,11285538 ! pigment metabolic process GO:0042440 80 37 1,000 0,02509461 0,11264483 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,02637482 0,11817099 ! mitotic cell cycle checkpoint GO:0007093 76 38 1,000 0,02637482 0,11795134 ! lipid homeostasis GO:0055088 67 38 1,000 0,02637482 0,1177325 ! erythrocyte homeostasis GO:0034101 64 38 1,000 0,02637482 0,11751448 ! positive regulation of leukocyte proliferation GO:0070665 62 38 1,000 0,02637482 0,11729726 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! hormone metabolic process GO:0042445 157 97 2,000 0,02697287 0,11973567 ! ear morphogenesis GO:0042471 60 39 1,000 0,02768098 0,12265273 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,02768098 0,12242727 ! segmentation GO:0035282 67 39 1,000 0,02768098 0,12220263 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,02768098 0,12197882 ! skeletal muscle tissue development GO:0007519 186 99 2,000 0,02842179 0,12501432 GO:0060538|skeletal muscle organ development, ! regulation of hormone secretion GO:0046883 62 40 1,000 0,02901268 0,1273805 ! feeding behavior GO:0007631 59 40 1,000 0,02901268 0,12714848 ! mesenchymal cell development GO:0014031 87 40 1,000 0,02901268 0,1269173 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 91 40 1,000 0,02901268 0,12668696 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,03175117 0,13839368 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of protein complex disassembly GO:0043242 101 42 1,000 0,03175117 0,13814342 ! monocarboxylic acid transport GO:0015718 85 42 1,000 0,03175117 0,13789407 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 1,000 0,03175117 0,13764561 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,03276791 0,14179781 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03276791 0,14154324 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,03276791 0,14128958 ! neuron fate determination GO:0048664 7 5 0,000 0,03276791 0,14103682 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03276791 0,14078497 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,03276791 0,14053402 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,03276791 0,14028396 ! polyol transport GO:0015791 12 5 0,000 0,03276791 0,14003478 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,03276791 0,13978649 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03276791 0,13953908 ! response to superoxide GO:0000303 10 5 0,000 0,03276791 0,13929255 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03276791 0,13904688 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,03276791 0,13880208 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,03276791 0,13855814 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03276791 0,13831506 ! female meiosis GO:0007143 7 5 0,000 0,03276791 0,13807282 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03276791 0,13783144 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03276791 0,1375909 ! cobalt ion transport GO:0006824 11 5 0,000 0,03276791 0,13735119 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,03276791 0,13711232 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,03276791 0,13687428 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,03276791 0,13663706 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03276791 0,13640066 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,03276791 0,13616508 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,03276791 0,13593032 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,03276791 0,13569636 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03276791 0,1354632 GO:0006451|translational readthrough, ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,03276791 0,13523085 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03276791 0,13499929 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03276791 0,13476852 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03276791 0,13453854 ! negative chemotaxis GO:0050919 14 5 0,000 0,03276791 0,13430934 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03276791 0,13408092 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03276791 0,13385328 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,03276791 0,13362641 ! behavioral response to pain GO:0048266 9 5 0,000 0,03276791 0,13340031 ! clathrin coat assembly GO:0048268 14 5 0,000 0,03276791 0,13317497 ! Notch receptor processing GO:0007220 8 5 0,000 0,03276791 0,13295039 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03276791 0,13272657 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03276791 0,1325035 ! micturition GO:0060073 9 5 0,000 0,03276791 0,13228118 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03276791 0,1320596 ! copulation GO:0007620 9 5 0,000 0,03276791 0,13183877 ! glial cell fate commitment GO:0021781 13 5 0,000 0,03276791 0,13161867 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,03276791 0,1313993 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03276791 0,13118067 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03276791 0,13096276 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03276791 0,13074558 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,03276791 0,13052911 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03276791 0,13031336 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03276791 0,13009832 ! grooming behavior GO:0007625 6 5 0,000 0,03276791 0,12988399 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03276791 0,12967037 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,03276791 0,12945744 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03276791 0,12924522 ! response to protozoan GO:0001562 10 5 0,000 0,03276791 0,12903369 ! positive regulation of glycolysis GO:0045821 14 5 0,000 0,03276791 0,12882285 ! lymph vessel development GO:0001945 10 5 0,000 0,03276791 0,1286127 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,03276791 0,12840323 ! endochondral ossification GO:0001958 16 5 0,000 0,03276791 0,12819444 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03276791 0,12798634 ! parathyroid gland development GO:0060017 13 5 0,000 0,03276791 0,1277789 ! anagen GO:0042640 6 5 0,000 0,03276791 0,12757214 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03276791 0,12736605 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03276791 0,12716062 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,03276791 0,12695585 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,03276791 0,12675174 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,03276791 0,12654829 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,03276791 0,12634549 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,03276791 0,12614333 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,03276791 0,12594183 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03276791 0,12574096 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,03276791 0,12554074 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,03276791 0,12534115 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03276791 0,1251422 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,03276791 0,12494387 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03276791 0,12474618 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03276791 0,1245491 ! histidine catabolic process GO:0006548 6 5 0,000 0,03276791 0,12435265 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03276791 0,12415682 ! valine metabolic process GO:0006573 10 5 0,000 0,03276791 0,12396161 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,03276791 0,12376701 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03276791 0,12357301 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,03276791 0,12337963 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,03276791 0,12318685 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03276791 0,12299467 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,03276791 0,12280309 ! polyol catabolic process GO:0046174 7 5 0,000 0,03276791 0,1226121 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03276791 0,12242171 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03276791 0,12223191 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03276791 0,1220427 ! muscle cell migration GO:0014812 8 5 0,000 0,03276791 0,12185407 ! mitochondrial fission GO:0000266 8 5 0,000 0,03276791 0,12166602 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,03276791 0,12147856 ! mRNA transcription GO:0009299 9 5 0,000 0,03276791 0,12129167 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,03276791 0,12110535 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,03276791 0,12091961 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,03276791 0,12073443 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03276791 0,12054982 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03276791 0,12036578 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03276791 0,12018229 GO:0060177|regulation of angiotensin metabolic process, ! response to food GO:0032094 6 5 0,000 0,03276791 0,11999937 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,03276791 0,119817 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03276791 0,11963518 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,03276791 0,11945391 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03276791 0,1192732 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,03276791 0,11909303 ! forebrain neuron development GO:0021884 13 5 0,000 0,03276791 0,1189134 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03276791 0,11873431 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,03276791 0,11855576 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03276791 0,11837775 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03276791 0,11820027 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,03276791 0,11802333 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03276791 0,11784691 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,03276791 0,11767102 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,03276791 0,11749565 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03276791 0,11732081 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,03276791 0,11714648 ! basic amino acid transport GO:0015802 11 5 0,000 0,03276791 0,11697268 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03276791 0,11679938 ! depyrimidination GO:0045008 10 5 0,000 0,03276791 0,1166266 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03276791 0,11645433 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03276791 0,11628257 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,03276791 0,11611132 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,03276791 0,11594056 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03276791 0,11577031 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03276791 0,11560056 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03276791 0,11543131 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,03276791 0,11526255 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,03276791 0,11509428 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03276791 0,11492651 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03276791 0,11475922 ! response to arsenic GO:0046685 10 5 0,000 0,03276791 0,11459242 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,03276791 0,1144261 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,03276791 0,11426027 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,03276791 0,11409491 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,03276791 0,11393003 ! response to cadmium ion GO:0046686 7 5 0,000 0,03276791 0,11376563 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,03276791 0,1136017 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,03276791 0,11343825 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03276791 0,11327526 ! decidualization GO:0046697 11 5 0,000 0,03276791 0,11311274 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,03276791 0,11295069 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,03276791 0,1127891 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03276791 0,11262798 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03276791 0,11246731 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,03276791 0,1123071 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03276791 0,11214734 ! neural tube patterning GO:0021532 7 5 0,000 0,03276791 0,11198804 ! embryonic cleavage GO:0040016 6 5 0,000 0,03276791 0,1118292 ! peroxisome fission GO:0016559 5 5 0,000 0,03276791 0,1116708 ! histone demethylation GO:0016577 10 5 0,000 0,03276791 0,11151285 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,03276791 0,11135534 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03276791 0,11119828 ! metaphase plate congression GO:0051310 7 5 0,000 0,03276791 0,11104167 ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03276791 0,11088549 ! enteric nervous system development GO:0048484 8 5 0,000 0,03276791 0,11072975 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,03276791 0,11057445 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,03276791 0,11041958 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,03276791 0,11026515 ! muscle cell proliferation GO:0033002 11 5 0,000 0,03276791 0,11011115 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03276791 0,10995758 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,03276791 0,10980443 ! plasminogen activation GO:0031639 5 5 0,000 0,03276791 0,10965171 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,03276791 0,10949942 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03276791 0,10934755 ! metaphase GO:0051323 8 5 0,000 0,03276791 0,1091961 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,03276791 0,10904507 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03276791 0,10889445 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03276791 0,10874425 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03276791 0,10859447 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03276791 0,10844509 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03276791 0,10829613 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,03276791 0,10814758 ! response to redox state GO:0051775 5 5 0,000 0,03276791 0,10799943 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,03276791 0,10785169 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,03276791 0,10770435 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03276791 0,10755741 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,03276791 0,10741088 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03276791 0,10726474 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,03276791 0,107119 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03276791 0,10697365 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,03276791 0,1068287 ! striatum development GO:0021756 9 5 0,000 0,03276791 0,10668414 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,03276791 0,10653998 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,03276791 0,1063962 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03276791 0,10625281 ! glial cell migration GO:0008347 11 5 0,000 0,03276791 0,1061098 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03276791 0,10596718 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03276791 0,10582494 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03276791 0,10568309 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03276791 0,10554161 ! neuroprotection GO:0043526 6 5 0,000 0,03276791 0,10540051 ! neural plate development GO:0001840 8 5 0,000 0,03276791 0,10525979 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,03276791 0,10511944 ! regulation of sensory perception GO:0051931 7 5 0,000 0,03276791 0,10497947 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03276791 0,10483987 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,03276791 0,10470064 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,03276791 0,10456178 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03276791 0,10442329 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03276791 0,10428516 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03276791 0,1041474 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03276791 0,10401 ! spindle assembly GO:0051225 6 5 0,000 0,03276791 0,10387297 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,03276791 0,10373629 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,03276791 0,10359998 GO:0022011|myelination in the peripheral nervous system, ! drug metabolic process GO:0017144 6 5 0,000 0,03276791 0,10346402 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03276791 0,10332842 ! organ regeneration GO:0031100 7 5 0,000 0,03276791 0,10319317 ! carnitine metabolic process GO:0009437 7 5 0,000 0,03276791 0,10305828 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,03276791 0,10292374 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03276791 0,10278955 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,03315718 0,10387521 ! glucose transport GO:0015758 65 43 1,000 0,03315718 0,10374013 ! striated muscle contraction GO:0006941 77 43 1,000 0,03315718 0,10360541 ! hexose transport GO:0008645 67 44 1,000 0,03458718 0,10793354 GO:0015749|monosaccharide transport, ! male sex differentiation GO:0046661 76 44 1,000 0,03458718 0,10779373 ! biopolymer methylation GO:0043414 84 44 1,000 0,03458718 0,10765428 ! maintenance of location in cell GO:0051651 97 44 1,000 0,03458718 0,10751519 ! regulation of actin filament polymerization GO:0030833 87 45 1,000 0,03604081 0,11188927 ! glycolysis GO:0006096 65 45 1,000 0,03604081 0,11174508 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,03604081 0,11160126 ! regulation of gene-specific transcription GO:0032583 96 46 1,000 0,03751768 0,11602512 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,03751768 0,11587618 ! response to calcium ion GO:0051592 81 47 1,000 0,03901744 0,12035379 ! endosome transport GO:0016197 108 47 1,000 0,03901744 0,12019968 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,03901744 0,12004598 ! JNK cascade GO:0007254 91 47 1,000 0,03901744 0,11989266 ! regulation of JNK cascade GO:0046328 94 47 1,000 0,03901744 0,11973974 ! methylation GO:0032259 90 47 1,000 0,03901744 0,1195872 ! protein homooligomerization GO:0051260 76 47 1,000 0,03901744 0,11943506 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03919214 0,11981738 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03919214 0,11966533 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,03919214 0,11951366 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03919214 0,11936238 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03919214 0,11921148 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,03919214 0,11906096 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,03919214 0,11891082 ! sleep GO:0030431 13 6 0,000 0,03919214 0,11876106 ! response to oxygen radical GO:0000305 11 6 0,000 0,03919214 0,11861167 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,03919214 0,11846266 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,03919214 0,11831403 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,03919214 0,11816577 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,03919214 0,11801787 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03919214 0,11787035 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03919214 0,1177232 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,03919214 0,11757641 ! forebrain regionalization GO:0021871 8 6 0,000 0,03919214 0,11742999 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03919214 0,11728393 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03919214 0,11713824 ! response to zinc ion GO:0010043 9 6 0,000 0,03919214 0,1169929 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03919214 0,11684793 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,03919214 0,11670332 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,03919214 0,11655906 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03919214 0,11641516 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03919214 0,11627162 ! malate metabolic process GO:0006108 11 6 0,000 0,03919214 0,11612842 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,03919214 0,11598559 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,03919214 0,1158431 ! protein refolding GO:0042026 15 6 0,000 0,03919214 0,11570096 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03919214 0,11555917 ! opsonization GO:0008228 8 6 0,000 0,03919214 0,11541772 ! mating behavior GO:0007617 7 6 0,000 0,03919214 0,11527663 ! neuron remodeling GO:0016322 15 6 0,000 0,03919214 0,11513587 ! erythrocyte maturation GO:0043249 7 6 0,000 0,03919214 0,11499546 ! equilibrioception GO:0050957 14 6 0,000 0,03919214 0,1148554 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,03919214 0,11471567 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,03919214 0,11457628 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03919214 0,11443723 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,03919214 0,11429852 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03919214 0,11416015 ! response to interferon-gamma GO:0034341 15 6 0,000 0,03919214 0,1140221 ! toxin metabolic process GO:0009404 11 6 0,000 0,03919214 0,1138844 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03919214 0,11374702 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03919214 0,11360998 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,03919214 0,11347326 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,03919214 0,11333688 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,03919214 0,11320082 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,03919214 0,11306508 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,03919214 0,11292968 ! thymic T cell selection GO:0045061 12 6 0,000 0,03919214 0,11279459 ! protein lipoylation GO:0009249 10 6 0,000 0,03919214 0,11265983 ! cysteine metabolic process GO:0006534 10 6 0,000 0,03919214 0,11252539 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03919214 0,11239128 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03919214 0,11225748 ! glutamate catabolic process GO:0006538 10 6 0,000 0,03919214 0,112124 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,03919214 0,11199083 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03919214 0,11185798 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,03919214 0,11172545 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,03919214 0,11159323 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03919214 0,11146132 ! hyperosmotic response GO:0006972 9 6 0,000 0,03919214 0,11132973 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,03919214 0,11119844 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,03919214 0,11106747 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03919214 0,1109368 ! urea metabolic process GO:0019627 7 6 0,000 0,03919214 0,11080644 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03919214 0,11067639 ! neutrophil activation GO:0042119 8 6 0,000 0,03919214 0,11054664 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03919214 0,11041719 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03919214 0,11028805 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03919214 0,11015921 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03919214 0,11003067 ! neuron apoptosis GO:0051402 9 6 0,000 0,03919214 0,10990243 ! nucleoside salvage GO:0043174 9 6 0,000 0,03919214 0,10977448 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,03919214 0,10964684 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03919214 0,10951949 ! T cell mediated immunity GO:0002456 16 6 0,000 0,03919214 0,10939244 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03919214 0,10926568 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,03919214 0,10913921 ! carnitine transport GO:0015879 10 6 0,000 0,03919214 0,10901304 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,03919214 0,10888716 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03919214 0,10876157 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,03919214 0,10863627 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,03919214 0,10851126 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,03919214 0,10838653 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,03919214 0,10826209 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,03919214 0,10813794 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,03919214 0,10801407 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,03919214 0,10789048 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03919214 0,10776718 GO:0045686|negative regulation of glial cell differentiation, ! astrocyte development GO:0014002 15 6 0,000 0,03919214 0,10764416 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,03919214 0,10752141 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03919214 0,10739895 ! interaction with symbiont GO:0051702 13 6 0,000 0,03919214 0,10727677 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03919214 0,10715486 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03919214 0,10703324 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,03919214 0,10691188 ! response to copper ion GO:0046688 10 6 0,000 0,03919214 0,1067908 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,03919214 0,10667 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03919214 0,10654947 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03919214 0,10642921 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03919214 0,10630922 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,03919214 0,10618951 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03919214 0,10607006 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,03919214 0,10595088 ! hair follicle maturation GO:0048820 7 6 0,000 0,03919214 0,10583196 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03919214 0,10571332 ! Schwann cell development GO:0014044 15 6 0,000 0,03919214 0,10559494 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,03919214 0,10547682 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03919214 0,10535897 ! subpallium development GO:0021544 10 6 0,000 0,03919214 0,10524138 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,03919214 0,10512406 ! histone ubiquitination GO:0016574 8 6 0,000 0,03919214 0,10500699 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,03919214 0,10489019 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03919214 0,10477365 ! G2 phase GO:0051319 16 6 0,000 0,03919214 0,10465736 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,03919214 0,10454133 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03919214 0,10442556 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,03919214 0,10431005 ! membrane to membrane docking GO:0022614 14 6 0,000 0,03919214 0,10419479 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03919214 0,10407978 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,03919214 0,10396503 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03919214 0,10385053 ! receptor internalization GO:0031623 10 6 0,000 0,03919214 0,10373628 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,03919214 0,10362229 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,03919214 0,10350854 ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,03919214 0,10339504 ! protein deubiquitination GO:0016579 14 6 0,000 0,03919214 0,1032818 ! protein destabilization GO:0031648 9 6 0,000 0,03919214 0,1031688 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03919214 0,10305604 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,03919214 0,10294354 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03919214 0,10283128 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,03919214 0,10271926 ! progesterone metabolic process GO:0042448 10 6 0,000 0,03919214 0,10260749 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,03919214 0,10249596 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,03919214 0,10238467 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,03919214 0,10227362 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,03919214 0,10216282 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03919214 0,10205225 ! determination of adult lifespan GO:0008340 15 6 0,000 0,03919214 0,10194193 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,03919214 0,10183184 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,03919214 0,10172199 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03919214 0,10161237 ! catecholamine transport GO:0051937 9 6 0,000 0,03919214 0,10150299 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,03919214 0,10139385 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03919214 0,10128494 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03919214 0,10117627 ! maternal placenta development GO:0001893 12 6 0,000 0,03919214 0,10106783 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,03919214 0,10095962 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03919214 0,10085164 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,03919214 0,10074389 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03919214 0,10063637 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,03919214 0,10052908 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,03919214 0,10042202 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 1,000 0,0405397 0,10376439 ! regulation of action potential GO:0001508 95 49 1,000 0,04208412 0,10760298 ! regulation of protein complex disassembly GO:0043244 113 49 1,000 0,04208412 0,10748875 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 1,000 0,04208412 0,10737476 ! response to temperature stimulus GO:0009266 76 49 1,000 0,04208412 0,10726102 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,04208412 0,10714752 ! regulation of ossification GO:0030278 117 50 1,000 0,04365034 0,11101766 ! histone modification GO:0016570 91 50 1,000 0,04365034 0,11090043 ! regulation of gene expression, epigenetic GO:0040029 105 50 1,000 0,04365034 0,11078345 ! positive regulation of binding GO:0051099 78 51 1,000 0,04523799 0,11469189 ! embryonic skeletal system development GO:0048706 85 51 1,000 0,04523799 0,11457116 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 1,000 0,04523799 0,11445068 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 1,000 0,04523799 0,11433046 ! vesicle organization GO:0016050 107 51 1,000 0,04523799 0,11421049 ! epithelial tube morphogenesis GO:0060562 98 51 1,000 0,04523799 0,11409078 ! tRNA transcription GO:0009304 14 7 0,000 0,04557391 0,11481762 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,04557391 0,11469752 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,04557391 0,11457767 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04557391 0,11445807 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,04557391 0,11433871 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04557391 0,11421961 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,04557391 0,11410076 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04557391 0,11398215 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,04557391 0,11386379 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04557391 0,11374567 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04557391 0,1136278 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,04557391 0,11351017 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04557391 0,11339279 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,04557391 0,11327565 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,04557391 0,11315875 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,04557391 0,11304209 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,04557391 0,11292567 ! glycolipid transport GO:0046836 10 7 0,000 0,04557391 0,11280949 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04557391 0,11269355 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,04557391 0,11257785 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04557391 0,11246239 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,04557391 0,11234716 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04557391 0,11223217 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,04557391 0,11211741 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,04557391 0,11200289 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,04557391 0,1118886 ! mRNA stabilization GO:0048255 18 7 0,000 0,04557391 0,11177454 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 14 7 0,000 0,04557391 0,11166072 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,04557391 0,11154713 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,04557391 0,11143377 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,04557391 0,11132064 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04557391 0,11120774 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04557391 0,11109506 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04557391 0,11098262 ! rhythmic behavior GO:0007622 15 7 0,000 0,04557391 0,1108704 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,04557391 0,11075841 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,04557391 0,11064665 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,04557391 0,11053511 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04557391 0,11042379 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,04557391 0,1103127 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04557391 0,11020184 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,04557391 0,11009119 ! mechanosensory behavior GO:0007638 14 7 0,000 0,04557391 0,10998077 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,04557391 0,10987057 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04557391 0,10976059 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,04557391 0,10965083 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04557391 0,10954129 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04557391 0,10943196 ! spinal cord patterning GO:0021511 13 7 0,000 0,04557391 0,10932286 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,04557391 0,10921397 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04557391 0,1091053 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,04557391 0,10899685 ! adrenal gland development GO:0030325 17 7 0,000 0,04557391 0,10888861 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,04557391 0,10878058 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,04557391 0,10867277 ! ovulation GO:0030728 9 7 0,000 0,04557391 0,10856518 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,04557391 0,10845779 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,04557391 0,10835062 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,04557391 0,10824366 ! microtubule nucleation GO:0007020 20 7 0,000 0,04557391 0,10813691 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04557391 0,10803037 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04557391 0,10792404 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,04557391 0,10781792 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,04557391 0,10771201 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,04557391 0,10760631 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04557391 0,10750081 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04557391 0,10739552 ! galactose metabolic process GO:0006012 13 7 0,000 0,04557391 0,10729044 ! vesicle fusion GO:0006906 17 7 0,000 0,04557391 0,10718556 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04557391 0,10708089 ! intracellular pH reduction GO:0051452 11 7 0,000 0,04557391 0,10697642 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04557391 0,10687215 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,04557391 0,10676809 ! purine salvage GO:0043101 10 7 0,000 0,04557391 0,10666423 ! nucleoside transport GO:0015858 8 7 0,000 0,04557391 0,10656057 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,04557391 0,10645711 ! parturition GO:0007567 14 7 0,000 0,04557391 0,10635386 ! rRNA modification GO:0000154 14 7 0,000 0,04557391 0,1062508 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,04557391 0,10614794 ! spindle checkpoint GO:0031577 15 7 0,000 0,04557391 0,10604529 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,04557391 0,10594283 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,04557391 0,10584057 ! macrophage differentiation GO:0030225 11 7 0,000 0,04557391 0,1057385 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04557391 0,10563663 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04557391 0,10553496 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,04557391 0,10543349 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04557391 0,10533221 ! fibrinolysis GO:0042730 10 7 0,000 0,04557391 0,10523112 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 0,000 0,04557391 0,10513023 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04557391 0,10502953 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,04557391 0,10492902 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,04557391 0,10482871 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04557391 0,10472858 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,04557391 0,10462865 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04557391 0,10452891 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,04557391 0,10442936 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,04557391 0,10433 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,04557391 0,10423082 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,04557391 0,10413184 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04557391 0,10403304 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,04557391 0,10393443 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,04557391 0,10383601 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04557391 0,10373777 ! regulation of meiosis GO:0040020 12 7 0,000 0,04557391 0,10363972 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,04557391 0,10354186 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,04557391 0,10344418 GO:0002714|positive regulation of B cell mediated immunity, ! oxygen homeostasis GO:0032364 12 7 0,000 0,04557391 0,10334668 ! transcription termination GO:0006353 13 7 0,000 0,04557391 0,10324937 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,04557391 0,10315224 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04557391 0,10305529 ! anaphase GO:0051322 17 7 0,000 0,04557391 0,10295852 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,04557391 0,10286194 ! axonal fasciculation GO:0007413 18 7 0,000 0,04557391 0,10276554 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,04557391 0,10266931 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,04557391 0,10257327 ! diuresis GO:0030146 12 7 0,000 0,04557391 0,10247741 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04557391 0,10238172 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04557391 0,10228622 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04557391 0,10219089 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,04557391 0,10209574 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,04557391 0,10200077 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04557391 0,10190597 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04557391 0,10181135 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04557391 0,10171691 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04557391 0,10162264 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,04557391 0,10152854 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04557391 0,10143462 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,04557391 0,10134088 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,04557391 0,1012473 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,04557391 0,1011539 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04557391 0,10106067 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,04557391 0,10096761 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,04557391 0,10087473 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,04557391 0,10078201 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,04557391 0,10068946 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,04557391 0,10059709 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04557391 0,10050488 ! muscle adaptation GO:0043500 14 7 0,000 0,04557391 0,10041285 ! embryonic heart tube development GO:0035050 10 7 0,000 0,04557391 0,10032098 ! retina homeostasis GO:0001895 12 7 0,000 0,04557391 0,10022928 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,04557391 0,10013774 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,04557391 0,10004638 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,04557391 0,09995518 ! protein prenylation GO:0018342 18 7 0,000 0,04557391 0,09986414 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,04557391 0,09977327 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,04557391 0,09968257 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04557391 0,09959203 ! regulation of angiogenesis GO:0045765 114 52 1,000 0,04684673 0,10228061 ! positive regulation of growth GO:0045927 90 52 1,000 0,04684673 0,10218788 ! covalent chromatin modification GO:0016569 101 52 1,000 0,04684673 0,10209532 ! synapse organization GO:0050808 85 52 1,000 0,04684673 0,10200292 ! regulation of translational initiation GO:0006446 82 53 1,000 0,04847621 0,10545548 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 1,000 0,04847621 0,10536022 ! regulation of protein polymerization GO:0032271 103 53 1,000 0,04847621 0,10526513 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,05012609 0,10874966 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 1,000 0,05012609 0,10865169 ! chloride transport GO:0006821 90 55 1,000 0,05179603 0,11217034 ! glucose catabolic process GO:0006007 82 55 1,000 0,05179603 0,11206946 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,05179603 0,11196877 ! RNA elongation GO:0006354 79 55 1,000 0,05179603 0,11186826 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,05191351 0,11202143 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,05191351 0,11192105 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,05191351 0,11182085 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,05191351 0,11172084 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05191351 0,111621 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05191351 0,11152133 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,05191351 0,11142185 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,05191351 0,11132254 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,05191351 0,11122341 ! meiotic prophase I GO:0007128 13 8 0,000 0,05191351 0,11112446 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05191351 0,11102568 ! oligopeptide transport GO:0006857 15 8 0,000 0,05191351 0,11092708 ! UTP metabolic process GO:0046051 8 8 0,000 0,05191351 0,11082865 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,05191351 0,1107304 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,05191351 0,11063232 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,05191351 0,11053442 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05191351 0,11043669 ! succinate metabolic process GO:0006105 14 8 0,000 0,05191351 0,11033913 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05191351 0,11024174 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,05191351 0,11014453 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,05191351 0,11004748 ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05191351 0,10995061 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05191351 0,10985391 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,05191351 0,10975738 ! reflex GO:0060004 16 8 0,000 0,05191351 0,10966101 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,05191351 0,10956482 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,05191351 0,10946879 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05191351 0,10937294 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,05191351 0,10927725 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,05191351 0,10918173 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,05191351 0,10908637 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05191351 0,10899118 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,05191351 0,10889616 ! astrocyte differentiation GO:0048708 18 8 0,000 0,05191351 0,1088013 ! histidine metabolic process GO:0006547 16 8 0,000 0,05191351 0,10870661 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05191351 0,10861208 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,05191351 0,10851772 ! glycine catabolic process GO:0006546 13 8 0,000 0,05191351 0,10842352 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,05191351 0,10832948 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,05191351 0,10823561 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,05191351 0,1081419 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,05191351 0,10804835 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05191351 0,10795496 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,05191351 0,10786174 ! macrophage activation GO:0042116 12 8 0,000 0,05191351 0,10776867 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05191351 0,10767577 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,05191351 0,10758303 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,05191351 0,10749044 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,05191351 0,10739802 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05191351 0,10730575 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,05191351 0,10721364 ! osteoblast development GO:0002076 16 8 0,000 0,05191351 0,10712169 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,05191351 0,1070299 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,05191351 0,10693827 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,05191351 0,10684679 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,05191351 0,10675546 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,05191351 0,1066643 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05191351 0,10657329 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,05191351 0,10648243 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05191351 0,10639173 ! intermediate filament organization GO:0045109 12 8 0,000 0,05191351 0,10630119 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,05191351 0,10621079 ! cellular extravasation GO:0045123 12 8 0,000 0,05191351 0,10612056 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,05191351 0,10603047 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,05191351 0,10594054 ! response to antibiotic GO:0046677 11 8 0,000 0,05191351 0,10585076 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,05191351 0,10576113 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,05191351 0,10567165 ! DNA topological change GO:0006265 12 8 0,000 0,05191351 0,10558233 ! response to tropane GO:0014073 15 8 0,000 0,05191351 0,10549315 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05191351 0,10540413 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,05191351 0,10531526 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05191351 0,10522653 ! mast cell activation GO:0045576 14 8 0,000 0,05191351 0,10513796 ! multicellular organismal aging GO:0010259 18 8 0,000 0,05191351 0,10504953 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,05191351 0,10496126 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,05191351 0,10487313 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,05191351 0,10478515 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05191351 0,10469731 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05191351 0,10460963 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,05191351 0,10452209 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05191351 0,10443469 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05191351 0,10434745 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,05191351 0,10426035 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,05191351 0,10417339 ! intracellular lipid transport GO:0032365 13 8 0,000 0,05191351 0,10408658 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05191351 0,10399991 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05191351 0,10391339 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,05191351 0,10382701 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,05191351 0,10374078 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05191351 0,10365468 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,05191351 0,10356873 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,05191351 0,10348293 ! hormone catabolic process GO:0042447 17 8 0,000 0,05191351 0,10339726 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05191351 0,10331174 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,05191351 0,10322636 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,05191351 0,10314112 ! ATP catabolic process GO:0006200 11 8 0,000 0,05191351 0,10305602 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05191351 0,10297106 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05191351 0,10288624 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,05191351 0,10280156 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05191351 0,10271702 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05191351 0,10263262 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,05191351 0,10254835 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,05191351 0,10246423 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,05191351 0,10238024 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,05191351 0,10229639 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,05191351 0,10221268 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,05191351 0,1021291 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05191351 0,10204566 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,05191351 0,10196236 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05191351 0,1018792 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05191351 0,10179616 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,05191351 0,10171327 ! NAD biosynthetic process GO:0009435 13 8 0,000 0,05191351 0,10163051 ! regulation of actin filament length GO:0030832 105 56 1,000 0,05348569 0,10462322 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,05348569 0,10453823 ! regulation of bone remodeling GO:0046850 137 57 1,000 0,05519474 0,10779102 ! muscle fiber development GO:0048747 112 57 1,000 0,05519474 0,1077036 ! lipid modification GO:0030258 97 57 1,000 0,05519474 0,10761632 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,05519474 0,10752918 ! maintenance of location GO:0051235 118 57 1,000 0,05519474 0,10744218 ! regulation of tissue remodeling GO:0034103 140 58 1,000 0,05692285 0,11071655 ! adult behavior GO:0030534 99 58 1,000 0,05692285 0,11062712 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,05692285 0,11053783 ! regulation of developmental growth GO:0048638 15 9 0,000 0,0582112 0,11294851 ! axon extension GO:0048675 15 9 0,000 0,0582112 0,11285749 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,0582112 0,11276662 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,0582112 0,1126759 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,0582112 0,11258533 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,0582112 0,1124949 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,0582112 0,11240461 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,0582112 0,11231447 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,0582112 0,11222448 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,0582112 0,11213463 ! phosphate transport GO:0006817 19 9 0,000 0,0582112 0,11204492 ! reproductive behavior GO:0019098 19 9 0,000 0,0582112 0,11195535 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,0582112 0,11186593 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,0582112 0,11177665 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,0582112 0,11168752 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,0582112 0,11159852 ! GTP metabolic process GO:0046039 9 9 0,000 0,0582112 0,11150967 ! RNA methylation GO:0001510 15 9 0,000 0,0582112 0,11142096 ! induction of positive chemotaxis GO:0050930 15 9 0,000 0,0582112 0,11133239 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,0582112 0,11124396 ! artery development GO:0060840 24 9 0,000 0,0582112 0,11115567 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,0582112 0,11106752 ! regulation of glycolysis GO:0006110 21 9 0,000 0,0582112 0,11097951 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,0582112 0,11089165 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,0582112 0,11080391 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,0582112 0,11071632 ! chemosensory behavior GO:0007635 20 9 0,000 0,0582112 0,11062887 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,0582112 0,11054155 ! leukocyte degranulation GO:0043299 16 9 0,000 0,0582112 0,11045438 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,0582112 0,11036733 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,0582112 0,11028043 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,0582112 0,11019366 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,0582112 0,11010703 ! protein targeting to ER GO:0045047 22 9 0,000 0,0582112 0,11002054 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,0582112 0,10993418 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,0582112 0,10984796 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,0582112 0,10976187 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,0582112 0,10967592 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,0582112 0,1095901 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,0582112 0,10950442 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,0582112 0,10941887 ! mannose metabolic process GO:0006013 13 9 0,000 0,0582112 0,10933345 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,0582112 0,10924817 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,0582112 0,10916301 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,0582112 0,109078 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,0582112 0,10899311 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,0582112 0,10890836 ! ruffle organization GO:0031529 15 9 0,000 0,0582112 0,10882374 ! retinol metabolic process GO:0042572 18 9 0,000 0,0582112 0,10873925 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,0582112 0,10865489 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,0582112 0,10857066 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,0582112 0,10848656 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,0582112 0,10840259 GO:0030204|chondroitin sulfate metabolic process, ! protein heterooligomerization GO:0051291 16 9 0,000 0,0582112 0,10831875 ! oligodendrocyte development GO:0014003 10 9 0,000 0,0582112 0,10823504 ! segment specification GO:0007379 13 9 0,000 0,0582112 0,10815147 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,0582112 0,10806802 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,0582112 0,10798469 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,0582112 0,1079015 ! response to amine stimulus GO:0014075 13 9 0,000 0,0582112 0,10781844 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,0582112 0,1077355 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,0582112 0,10765269 ! erythrocyte development GO:0048821 15 9 0,000 0,0582112 0,10757001 ! gas homeostasis GO:0033483 16 9 0,000 0,0582112 0,10748745 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,0582112 0,10740502 ! renal water homeostasis GO:0003091 14 9 0,000 0,0582112 0,10732272 ! postreplication repair GO:0006301 22 9 0,000 0,0582112 0,10724054 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,0582112 0,10715849 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,0582112 0,10707657 ! icosanoid secretion GO:0032309 15 9 0,000 0,0582112 0,10699477 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,0582112 0,10691309 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,0582112 0,10683154 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,0582112 0,10675011 ! regulation of cell division GO:0051302 15 9 0,000 0,0582112 0,10666881 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,0582112 0,10658763 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,0582112 0,10650658 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,0582112 0,10642564 ! sterol catabolic process GO:0016127 11 9 0,000 0,0582112 0,10634484 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,0582112 0,10626415 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,0582112 0,10618358 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,0582112 0,10610314 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,0582112 0,10602282 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,0582112 0,10594262 ! musculoskeletal movement GO:0050881 14 9 0,000 0,0582112 0,10586255 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,0582112 0,10578259 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,0582112 0,10570275 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,0582112 0,10562304 ! purine base metabolic process GO:0006144 21 9 0,000 0,0582112 0,10554344 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,0582112 0,10546397 ! pigment granule transport GO:0051904 17 9 0,000 0,0582112 0,10538461 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,0582112 0,10530537 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,0582112 0,10522626 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,0582112 0,10514726 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,0582112 0,10506838 ! mitochondrion localization GO:0051646 15 9 0,000 0,0582112 0,10498962 ! regulation of cellular component size GO:0032535 109 59 1,000 0,05866969 0,10573729 ! establishment of organelle localization GO:0051656 109 59 1,000 0,05866969 0,10565815 ! camera-type eye development GO:0043010 116 60 1,000 0,06043495 0,10875579 ! negative regulation of response to stimulus GO:0048585 100 60 1,000 0,06043495 0,10867451 ! kidney development GO:0001822 122 60 1,000 0,06043495 0,10859335 ! regulation of protein complex assembly GO:0043254 117 61 1,000 0,0622183 0,11171436 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,06446727 0,11566611 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,06446727 0,11557992 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,06446727 0,11549386 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,06446727 0,11540793 ! synapsis GO:0007129 13 10 0,000 0,06446727 0,11532212 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,06446727 0,11523644 ! N-glycan processing GO:0006491 20 10 0,000 0,06446727 0,11515089 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,06446727 0,11506547 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,06446727 0,11498017 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,06446727 0,114895 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,06446727 0,11480996 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 0,000 0,06446727 0,11472504 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,06446727 0,11464025 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,06446727 0,11455558 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,06446727 0,11447104 ! androgen metabolic process GO:0008209 17 10 0,000 0,06446727 0,11438662 ! phospholipid efflux GO:0033700 16 10 0,000 0,06446727 0,11430232 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,06446727 0,11421815 ! lung alveolus development GO:0048286 26 10 0,000 0,06446727 0,11413411 ! pathogenesis GO:0009405 13 10 0,000 0,06446727 0,11405019 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06446727 0,11396639 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,06446727 0,11388271 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,06446727 0,11379916 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,06446727 0,11371573 ! endoderm development GO:0007492 16 10 0,000 0,06446727 0,11363242 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,06446727 0,11354923 ! arginine catabolic process GO:0006527 13 10 0,000 0,06446727 0,11346617 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,06446727 0,11338323 ! proline metabolic process GO:0006560 13 10 0,000 0,06446727 0,1133004 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,06446727 0,1132177 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,06446727 0,11313512 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,06446727 0,11305266 ! V(D)J recombination GO:0033151 28 10 0,000 0,06446727 0,11297032 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06446727 0,1128881 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,06446727 0,112806 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,06446727 0,11272402 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,06446727 0,11264216 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,06446727 0,11256042 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,06446727 0,11247879 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,06446727 0,11239728 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,06446727 0,1123159 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,06446727 0,11223463 ! macroautophagy GO:0016236 17 10 0,000 0,06446727 0,11215347 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,06446727 0,11207244 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,06446727 0,11199152 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,06446727 0,11191072 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,06446727 0,11183003 ! copper ion homeostasis GO:0055070 13 10 0,000 0,06446727 0,11174946 ! regulation of bone resorption GO:0045124 25 10 0,000 0,06446727 0,11166901 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,06446727 0,11158867 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,06446727 0,11150845 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,06446727 0,11142834 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,06446727 0,11134835 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 0,000 0,06446727 0,11126847 ! blastoderm segmentation GO:0007350 18 10 0,000 0,06446727 0,11118871 ! response to dsRNA GO:0043331 20 10 0,000 0,06446727 0,11110906 ! DNA ligation GO:0006266 19 10 0,000 0,06446727 0,11102953 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06446727 0,11095011 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,06446727 0,1108708 ! melanosome localization GO:0032400 16 10 0,000 0,06446727 0,11079161 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,06446727 0,11071253 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,06446727 0,11063356 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,06446727 0,11055471 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,06446727 0,11047596 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,06446727 0,11039733 ! mRNA cleavage GO:0006379 17 10 0,000 0,06446727 0,11031881 ! protein sumoylation GO:0016925 15 10 0,000 0,06446727 0,11024041 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,06446727 0,11016211 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06446727 0,11008393 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,06446727 0,11000585 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,06446727 0,10992789 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,06446727 0,10985004 ! salivary gland development GO:0007431 27 10 0,000 0,06446727 0,10977229 ! prophase GO:0051324 15 10 0,000 0,06446727 0,10969466 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06446727 0,10961714 ! apical protein localization GO:0045176 15 10 0,000 0,06446727 0,10953973 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,06446727 0,10946242 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,06446727 0,10938523 ! positive regulation of leukocyte migration GO:0002687 25 10 0,000 0,06446727 0,10930814 ! midbrain development GO:0030901 13 10 0,000 0,06446727 0,10923116 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06446727 0,10915429 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,06446727 0,10907753 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,06446727 0,10900088 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,06446727 0,10892433 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,06446727 0,1088479 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,06446727 0,10877157 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,06446727 0,10869534 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 0,000 0,06446727 0,10861922 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 23 10 0,000 0,06446727 0,10854321 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,06446727 0,10846731 ! blastocyst formation GO:0001825 17 10 0,000 0,06446727 0,10839151 ! cerebellar cortex development GO:0021695 15 10 0,000 0,06446727 0,10831582 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,06446727 0,10824023 ! activation of innate immune response GO:0002218 12 10 0,000 0,06446727 0,10816475 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,06446727 0,10808937 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,06446727 0,1080141 ! establishment of cell polarity GO:0030010 16 10 0,000 0,06446727 0,10793894 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,06446727 0,10786388 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,06446727 0,10778892 ! regulation of mitosis GO:0007088 105 63 1,000 0,06583803 0,11000438 GO:0051783|regulation of nuclear division, ! detection of external stimulus GO:0009581 91 63 1,000 0,06583803 0,10992804 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 1,000 0,06767379 0,11291479 ! multicellular organism reproduction GO:0032504 111 64 1,000 0,06767379 0,11283654 GO:0048609|reproductive process in a multicellular organism, ! negative regulation of muscle development GO:0048635 20 11 0,000 0,07068199 0,11777068 ! respiratory burst GO:0045730 17 11 0,000 0,07068199 0,11768918 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,07068199 0,11760779 ! neuron fate specification GO:0048665 17 11 0,000 0,07068199 0,11752651 ! telencephalon cell migration GO:0022029 20 11 0,000 0,07068199 0,11744535 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,07068199 0,1173643 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,07068199 0,11728336 ! thyroid gland development GO:0030878 26 11 0,000 0,07068199 0,11720253 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,07068199 0,11712181 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,07068199 0,1170412 ! response to pain GO:0048265 24 11 0,000 0,07068199 0,11696071 ! T cell proliferation GO:0042098 26 11 0,000 0,07068199 0,11688032 ! blood vessel remodeling GO:0001974 29 11 0,000 0,07068199 0,11680005 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 0,000 0,07068199 0,11671988 ! bone resorption GO:0045453 16 11 0,000 0,07068199 0,11663983 ! ventral spinal cord development GO:0021517 21 11 0,000 0,07068199 0,11655988 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,07068199 0,11648005 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07068199 0,11640032 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,07068199 0,1163207 ! melanocyte differentiation GO:0030318 21 11 0,000 0,07068199 0,11624119 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,07068199 0,11616179 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,07068199 0,1160825 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,07068199 0,11600332 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,07068199 0,11592424 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,07068199 0,11584528 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,07068199 0,11576642 ! UV protection GO:0009650 19 11 0,000 0,07068199 0,11568766 ! adult heart development GO:0007512 14 11 0,000 0,07068199 0,11560902 ! chondrocyte differentiation GO:0002062 24 11 0,000 0,07068199 0,11553048 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07068199 0,11545205 ! temperature homeostasis GO:0001659 17 11 0,000 0,07068199 0,11537372 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,07068199 0,1152955 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,07068199 0,11521739 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,07068199 0,11513938 ! regulation of organ growth GO:0046620 13 11 0,000 0,07068199 0,11506148 ! pigment granule localization GO:0051875 20 11 0,000 0,07068199 0,11498368 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,07068199 0,11490599 ! vasoconstriction GO:0042310 18 11 0,000 0,07068199 0,1148284 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,07068199 0,11475092 ! embryonic axis specification GO:0000578 18 11 0,000 0,07068199 0,11467354 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,07068199 0,11459627 ! snRNA metabolic process GO:0016073 24 11 0,000 0,07068199 0,1145191 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07068199 0,11444204 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,07068199 0,11436508 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,07068199 0,11428822 ! zymogen activation GO:0031638 15 11 0,000 0,07068199 0,11421146 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,07068199 0,11413481 ! neuroblast proliferation GO:0007405 24 11 0,000 0,07068199 0,11405826 ! nucleosome positioning GO:0016584 15 11 0,000 0,07068199 0,11398181 ! regulation of isotype switching GO:0045191 22 11 0,000 0,07068199 0,11390547 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,07068199 0,11382923 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,07068199 0,11375309 ! regulation of leukocyte migration GO:0002685 26 11 0,000 0,07068199 0,11367705 ! acid secretion GO:0046717 18 11 0,000 0,07068199 0,11360111 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07068199 0,11352528 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,07068199 0,11344954 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,07068199 0,11337391 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,07068199 0,11329838 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,07068199 0,11322295 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,07068199 0,11314762 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,07068199 0,11307238 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07068199 0,11299725 ! negative regulation of glucose import GO:0046325 17 11 0,000 0,07068199 0,11292222 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 25 11 0,000 0,07068199 0,11284729 ! embryonic gut development GO:0048566 15 11 0,000 0,07068199 0,11277246 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,07068199 0,11269772 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,07068199 0,11262309 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,07068199 0,11254855 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,07068199 0,11247412 ! defense response to fungus GO:0050832 13 11 0,000 0,07068199 0,11239978 ! developmental induction GO:0031128 19 11 0,000 0,07068199 0,11232554 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,07068199 0,1122514 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07068199 0,11217735 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,07068199 0,11210341 ! sequestering of metal ion GO:0051238 14 11 0,000 0,07068199 0,11202956 ! lamellipodium assembly GO:0030032 20 11 0,000 0,07068199 0,1119558 ! regulation of embryonic development GO:0045995 27 11 0,000 0,07068199 0,11188215 ! nucleus localization GO:0051647 19 11 0,000 0,07068199 0,11180859 ! regulation of synapse organization GO:0050807 17 11 0,000 0,07068199 0,11173513 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 1,000 0,07139555 0,11278903 ! fatty acid biosynthetic process GO:0006633 124 66 1,000 0,07139555 0,11271502 ! secondary metabolic process GO:0019748 116 66 1,000 0,07139555 0,11264111 ! cell projection assembly GO:0030031 120 66 1,000 0,07139555 0,1125673 ! regulation of cellular response to stress GO:0080135 128 67 1,000 0,07328096 0,1154643 ! activation of MAPK activity GO:0000187 115 67 1,000 0,07328096 0,11538874 ! chromosome segregation GO:0007059 113 67 1,000 0,07328096 0,11531327 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 1,000 0,07328096 0,1152379 ! hexose catabolic process GO:0019320 104 67 1,000 0,07328096 0,11516263 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 1,000 0,07328096 0,11508746 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,07328096 0,11501239 ! regulation of lipase activity GO:0060191 130 68 1,000 0,07518232 0,1179196 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,07685563 0,12046557 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,07685563 0,12038714 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,07685563 0,12030881 ! positive regulation of cellular catabolic process GO:0031331 31 12 0,000 0,07685563 0,12023059 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,07685563 0,12015247 ! virus-host interaction GO:0019048 29 12 0,000 0,07685563 0,12007444 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,07685563 0,11999652 ! cartilage condensation GO:0001502 20 12 0,000 0,07685563 0,11991871 ! regulation of positive chemotaxis GO:0050926 19 12 0,000 0,07685563 0,11984099 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,07685563 0,11976337 ! protein complex disassembly GO:0043241 27 12 0,000 0,07685563 0,11968585 GO:0043624|cellular protein complex disassembly, ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,07685563 0,11960844 ! hippocampus development GO:0021766 26 12 0,000 0,07685563 0,11953112 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,07685563 0,1194539 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,07685563 0,11937679 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,07685563 0,11929977 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,07685563 0,11922285 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,07685563 0,11914603 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,07685563 0,11906931 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,07685563 0,11899269 ! drug transport GO:0015893 16 12 0,000 0,07685563 0,11891617 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,07685563 0,11883975 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,07685563 0,11876342 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,07685563 0,11868719 ! polyamine metabolic process GO:0006595 17 12 0,000 0,07685563 0,11861106 ! mitotic spindle organization GO:0007052 21 12 0,000 0,07685563 0,11853503 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,07685563 0,11845909 ! forebrain cell migration GO:0021885 21 12 0,000 0,07685563 0,11838325 ! asymmetric protein localization GO:0008105 20 12 0,000 0,07685563 0,11830751 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,07685563 0,11823187 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,07685563 0,11815632 ! entry into host cell GO:0030260 32 12 0,000 0,07685563 0,11808087 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,07685563 0,11800552 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07685563 0,11793026 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,07685563 0,1178551 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,07685563 0,11778003 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,07685563 0,11770506 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,07685563 0,11763018 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,07685563 0,1175554 ! protein homotetramerization GO:0051289 21 12 0,000 0,07685563 0,11748071 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,07685563 0,11740612 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,07685563 0,11733163 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07685563 0,11725723 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,07685563 0,11718292 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,07685563 0,1171087 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,07685563 0,11703458 ! cranial nerve development GO:0021545 20 12 0,000 0,07685563 0,11696056 ! fucose catabolic process GO:0019317 22 12 0,000 0,07685563 0,11688663 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,07685563 0,11681279 ! histone methylation GO:0016571 26 12 0,000 0,07685563 0,11673904 ! autonomic nervous system development GO:0048483 24 12 0,000 0,07685563 0,11666539 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,07685563 0,11659183 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,07685563 0,11651836 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,07685563 0,11644499 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,07685563 0,11637171 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,07685563 0,11629852 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,07685563 0,11622542 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,07685563 0,11615241 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 0,000 0,07685563 0,1160795 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,07685563 0,11600668 ! response to cold GO:0009409 17 12 0,000 0,07685563 0,11593395 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,07685563 0,11586131 ! cAMP-mediated signaling GO:0019933 120 69 1,000 0,07709935 0,11615594 ! humoral immune response GO:0006959 109 71 1,000 0,08097924 0,12192494 ! regulation of MAPKKK cascade GO:0043408 142 71 1,000 0,08097924 0,12184869 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,08294153 0,12472333 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 1,000 0,08294153 0,12464543 ! carbohydrate transport GO:0008643 110 72 1,000 0,08294153 0,12456762 ! cGMP metabolic process GO:0046068 18 13 0,000 0,08298846 0,12456035 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,08298846 0,12448269 ! regulation of chemokine production GO:0032642 18 13 0,000 0,08298846 0,12440513 ! peroxisomal transport GO:0043574 24 13 0,000 0,08298846 0,12432767 ! lipid localization GO:0010876 28 13 0,000 0,08298846 0,1242503 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,08298846 0,12417303 ! organelle fusion GO:0048284 32 13 0,000 0,08298846 0,12409586 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,08298846 0,12401878 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,08298846 0,1239418 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,08298846 0,12386491 ! endocrine pancreas development GO:0031018 22 13 0,000 0,08298846 0,12378812 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,08298846 0,12371142 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,08298846 0,12363482 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,08298846 0,12355831 ! methionine metabolic process GO:0006555 27 13 0,000 0,08298846 0,1234819 ! plasma membrane organization GO:0007009 24 13 0,000 0,08298846 0,12340558 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,08298846 0,12332936 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,08298846 0,12325323 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,08298846 0,1231772 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cell-cell junction assembly GO:0007043 27 13 0,000 0,08298846 0,12310125 ! cytokine metabolic process GO:0042107 22 13 0,000 0,08298846 0,12302541 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,08298846 0,12294965 ! exocrine system development GO:0035272 32 13 0,000 0,08298846 0,12287399 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 0,000 0,08298846 0,12279842 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,08298846 0,12272295 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,08298846 0,12264756 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,08298846 0,12257227 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,08298846 0,12249708 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,08298846 0,12242197 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,08298846 0,12234696 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,08298846 0,12227204 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,08298846 0,12219721 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,08298846 0,12212247 ! ribosome assembly GO:0042255 17 13 0,000 0,08298846 0,12204782 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,08298846 0,12197327 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,08298846 0,1218988 ! chromatin silencing GO:0006342 26 13 0,000 0,08298846 0,12182443 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,08298846 0,12175014 ! regulation of epidermis development GO:0045682 19 13 0,000 0,08298846 0,12167595 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08298846 0,12160185 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,08298846 0,12152784 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,08298846 0,12145391 ! regulation of mRNA stability GO:0043488 31 13 0,000 0,08298846 0,12138008 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,08298846 0,12130634 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,08298846 0,12123269 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,08298846 0,12115912 ! embryonic placenta development GO:0001892 23 13 0,000 0,08298846 0,12108565 ! insulin secretion GO:0030073 23 13 0,000 0,08298846 0,12101226 ! actin filament polymerization GO:0030041 24 13 0,000 0,08298846 0,12093897 ! acrosome reaction GO:0007340 18 13 0,000 0,08298846 0,12086576 ! regulation of blood pressure GO:0008217 125 73 1,000 0,08491835 0,12360166 ! axon guidance GO:0007411 139 73 1,000 0,08491835 0,12352693 ! regulation of actin cytoskeleton organization GO:0032956 149 74 1,000 0,08690941 0,12634686 ! eye development GO:0001654 143 74 1,000 0,08690941 0,12627056 ! organelle localization GO:0051640 136 74 1,000 0,08690941 0,12619436 ! rhythmic process GO:0048511 128 75 1,000 0,08891445 0,12902784 ! rRNA transcription GO:0009303 25 14 0,000 0,08908075 0,12919125 ! lactation GO:0007595 26 14 0,000 0,08908075 0,12911343 ! reproductive cellular process GO:0048610 20 14 0,000 0,08908075 0,12903569 ! tRNA modification GO:0006400 20 14 0,000 0,08908075 0,12895805 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,08908075 0,12888051 ! water transport GO:0006833 21 14 0,000 0,08908075 0,12880306 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,08908075 0,1287257 ! non-recombinational repair GO:0000726 25 14 0,000 0,08908075 0,12864843 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,08908075 0,12857126 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,08908075 0,12849418 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,08908075 0,12841719 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,08908075 0,12834029 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 0,000 0,08908075 0,12826349 ! regulated secretory pathway GO:0045055 23 14 0,000 0,08908075 0,12818677 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,08908075 0,12811015 ! arginine metabolic process GO:0006525 17 14 0,000 0,08908075 0,12803362 ! regulation of heart rate GO:0002027 24 14 0,000 0,08908075 0,12795719 ! organic alcohol transport GO:0015850 29 14 0,000 0,08908075 0,12788084 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,08908075 0,12780458 ! embryo implantation GO:0007566 30 14 0,000 0,08908075 0,12772842 ! neutral amino acid transport GO:0015804 26 14 0,000 0,08908075 0,12765234 ! L-amino acid transport GO:0015807 30 14 0,000 0,08908075 0,12757636 ! bone mineralization GO:0030282 17 14 0,000 0,08908075 0,12750047 ! stem cell development GO:0048864 43 14 0,000 0,08908075 0,12742466 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,08908075 0,12734895 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08908075 0,12727333 ! cerebellum development GO:0021549 21 14 0,000 0,08908075 0,1271978 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,08908075 0,12712235 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,08908075 0,127047 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,08908075 0,12697173 ! cofactor transport GO:0051181 26 14 0,000 0,08908075 0,12689656 ! NADP metabolic process GO:0006739 24 14 0,000 0,08908075 0,12682147 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,08908075 0,12674647 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,08908075 0,12667156 ! intestinal absorption GO:0050892 25 14 0,000 0,08908075 0,12659674 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,08908075 0,12652201 ! oxygen transport GO:0015671 21 14 0,000 0,08908075 0,12644737 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,08908075 0,12637281 ! male genitalia development GO:0030539 24 14 0,000 0,08908075 0,12629834 ! regulation of RNA stability GO:0043487 32 14 0,000 0,08908075 0,12622396 ! regulation of axon extension GO:0030516 37 14 0,000 0,08908075 0,12614967 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,08908075 0,12607546 ! steroid biosynthetic process GO:0006694 131 76 1,000 0,09093319 0,12862155 ! monosaccharide catabolic process GO:0046365 115 76 1,000 0,09093319 0,12854598 ! regulation of actin filament-based process GO:0032970 152 77 1,000 0,09296536 0,13134155 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,09513277 0,13432479 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,09513277 0,134246 ! superoxide anion generation GO:0042554 20 15 0,000 0,09513277 0,13416731 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,09513277 0,13408872 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,09513277 0,13401021 ! copper ion transport GO:0006825 20 15 0,000 0,09513277 0,13393179 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,09513277 0,13385347 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,09513277 0,13377524 ! sulfate transport GO:0008272 23 15 0,000 0,09513277 0,1336971 ! response to cAMP GO:0051591 22 15 0,000 0,09513277 0,13361905 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,09513277 0,1335411 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,09513277 0,13346323 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,09513277 0,13338545 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,09513277 0,13330777 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,09513277 0,13323017 ! response to hexose stimulus GO:0009746 22 15 0,000 0,09513277 0,13315267 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,09513277 0,13307525 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,09513277 0,13299793 ! pituitary gland development GO:0021983 29 15 0,000 0,09513277 0,1329207 ! vesicle coating GO:0006901 33 15 0,000 0,09513277 0,13284355 ! regulation of the force of heart contraction GO:0002026 26 15 0,000 0,09513277 0,13276649 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,09513277 0,13268953 ! regulation of exocytosis GO:0017157 22 15 0,000 0,09513277 0,13261265 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,09513277 0,13253586 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,09513277 0,13245917 ! regulation of vasodilation GO:0042312 26 15 0,000 0,09513277 0,13238255 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,09513277 0,13230603 ! histone deacetylation GO:0016575 20 15 0,000 0,09513277 0,1322296 ! mRNA splice site selection GO:0006376 38 15 0,000 0,09513277 0,13215325 ! tissue regeneration GO:0042246 26 15 0,000 0,09513277 0,132077 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,09513277 0,13200083 ! water homeostasis GO:0030104 27 15 0,000 0,09513277 0,13192475 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,09513277 0,13184875 ! muscle maintenance GO:0046716 26 15 0,000 0,09513277 0,13177285 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,09513277 0,13169703 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,09513277 0,1316213 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,09513277 0,13154565 ! dopamine metabolic process GO:0042417 35 15 0,000 0,09513277 0,1314701 ! heme biosynthetic process GO:0006783 29 15 0,000 0,09513277 0,13139463 ! cell killing GO:0001906 29 15 0,000 0,09513277 0,13131924 ! detection of bacterium GO:0016045 18 15 0,000 0,09513277 0,13124394 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,09513277 0,13116873 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,09513277 0,13109361 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,09513277 0,13101857 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,09513277 0,13094361 ! peptide hormone processing GO:0016486 23 15 0,000 0,09513277 0,13086875 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,09913984 0,13630312 ! protein import into nucleus GO:0006606 158 80 1,000 0,09913984 0,13622527 ! inorganic anion transport GO:0015698 138 80 1,000 0,09913984 0,13614752 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,10114477 0,13882164 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,10114477 0,13874249 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,10114477 0,13866343 ! bone remodeling GO:0046849 27 16 0,000 0,10114477 0,13858447 ! filopodium assembly GO:0046847 32 16 0,000 0,10114477 0,13850559 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,10114477 0,13842681 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,10114477 0,13834811 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,10114477 0,1382695 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,10114477 0,13819099 ! startle response GO:0001964 28 16 0,000 0,10114477 0,13811256 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,10114477 0,13803422 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,10114477 0,13795597 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,10114477 0,13787781 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,10114477 0,13779973 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,10114477 0,13772175 ! protein polyubiquitination GO:0000209 34 16 0,000 0,10114477 0,13764385 ! glutamate metabolic process GO:0006536 22 16 0,000 0,10114477 0,13756604 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,10114477 0,13748832 ! response to osmotic stress GO:0006970 25 16 0,000 0,10114477 0,13741069 ! lysosomal transport GO:0007041 26 16 0,000 0,10114477 0,13733314 ! fructose metabolic process GO:0006000 25 16 0,000 0,10114477 0,13725568 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,10114477 0,13717831 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,10114477 0,13710103 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,10114477 0,13702383 ! negative regulation of immune response GO:0050777 35 16 0,000 0,10114477 0,13694672 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,10114477 0,1368697 ! DNA replication initiation GO:0006270 27 16 0,000 0,10114477 0,13679276 ! neuron recognition GO:0008038 35 16 0,000 0,10114477 0,13671591 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,10114477 0,13663915 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,10114477 0,13656247 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,10114477 0,13648588 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,10114477 0,13640938 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,10114477 0,13633296 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,10114477 0,13625662 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,10114477 0,13618037 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,10114477 0,13610421 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,10114477 0,13602813 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,10114477 0,13595214 ! nuclear import GO:0051170 161 81 1,000 0,10122312 0,13598148 ! regulation of neuron differentiation GO:0045664 167 81 1,000 0,10122312 0,1359056 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,10331854 0,13864161 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,10331854 0,13856433 ! regulation of lyase activity GO:0051339 160 83 1,000 0,10542584 0,14131175 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,10711704 0,14349866 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,10711704 0,1434188 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,10711704 0,14333904 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,10711704 0,14325936 ! inositol metabolic process GO:0006020 28 17 0,000 0,10711704 0,14317977 ! gene silencing by RNA GO:0031047 36 17 0,000 0,10711704 0,14310027 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,10711704 0,14302086 ! glial cell development GO:0021782 27 17 0,000 0,10711704 0,14294154 ! limbic system development GO:0021761 36 17 0,000 0,10711704 0,1428623 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,10711704 0,14278315 ! adult walking behavior GO:0007628 33 17 0,000 0,10711704 0,14270409 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,10711704 0,14262512 ! heart looping GO:0001947 30 17 0,000 0,10711704 0,14254623 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,10711704 0,14246743 ! myoblast differentiation GO:0045445 45 17 0,000 0,10711704 0,14238872 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,10711704 0,1423101 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 0,000 0,10711704 0,14223156 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,10711704 0,14215311 ! glycine metabolic process GO:0006544 28 17 0,000 0,10711704 0,14207475 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,10711704 0,14199647 ! NAD metabolic process GO:0019674 29 17 0,000 0,10711704 0,14191828 ! membrane budding GO:0006900 37 17 0,000 0,10711704 0,14184017 ! DNA integration GO:0015074 29 17 0,000 0,10711704 0,14176215 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,10711704 0,14168422 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,10711704 0,14160637 ! genitalia development GO:0048806 30 17 0,000 0,10711704 0,1415286 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,10711704 0,14145093 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,10711704 0,14137333 ! neutrophil chemotaxis GO:0030593 27 17 0,000 0,10711704 0,14129583 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,10711704 0,1412184 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,10711704 0,14114107 ! steroid catabolic process GO:0006706 31 17 0,000 0,10711704 0,14106381 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,10711704 0,14098665 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,10711704 0,14090956 ! gas transport GO:0015669 25 17 0,000 0,10711704 0,14083256 ! organic cation transport GO:0015695 31 17 0,000 0,10711704 0,14075565 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,10711704 0,14067881 ! microspike assembly GO:0030035 36 17 0,000 0,10711704 0,14060207 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,10711704 0,1405254 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,10754479 0,14100968 ! response to unfolded protein GO:0006986 131 85 1,000 0,10967512 0,14372458 ! one-carbon metabolic process GO:0006730 154 85 1,000 0,10967512 0,14364634 ! alcohol catabolic process GO:0046164 130 86 1,000 0,1118166 0,14637146 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,11304981 0,1479053 ! neuron maturation GO:0042551 42 18 0,000 0,11304981 0,14782492 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,11304981 0,14774462 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,11304981 0,14766441 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,11304981 0,14758429 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,11304981 0,14750426 ! memory GO:0007613 31 18 0,000 0,11304981 0,14742431 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,11304981 0,14734445 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,11304981 0,14726467 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,11304981 0,14718498 GO:0042744|hydrogen peroxide catabolic process, ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,11304981 0,14710538 ! glutamine metabolic process GO:0006541 29 18 0,000 0,11304981 0,14702586 ! response to retinoic acid GO:0032526 26 18 0,000 0,11304981 0,14694643 ! response to fungus GO:0009620 21 18 0,000 0,11304981 0,14686709 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,11304981 0,14678783 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,11304981 0,14670866 ! vitamin transport GO:0051180 27 18 0,000 0,11304981 0,14662957 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,11304981 0,14655057 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,11304981 0,14647165 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,11304981 0,14639281 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,11304981 0,14631407 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 0,000 0,11304981 0,1462354 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,11304981 0,14615682 ! nerve development GO:0021675 28 18 0,000 0,11304981 0,14607833 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,11304981 0,14599992 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,11396899 0,14710804 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein localization in nucleus GO:0034504 176 87 1,000 0,11396899 0,14702916 ! positive regulation of protein modification process GO:0031401 136 88 1,000 0,11613205 0,1497394 ! protein secretion GO:0009306 39 19 0,000 0,11894337 0,15328213 ! positive regulation of translation GO:0045727 30 19 0,000 0,11894337 0,15320007 ! negative regulation of defense response GO:0031348 25 19 0,000 0,11894337 0,1531181 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,11894337 0,15303622 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,11894337 0,15295443 ! skin development GO:0043588 36 19 0,000 0,11894337 0,15287272 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,11894337 0,1527911 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,11894337 0,15270957 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,11894337 0,15262813 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,11894337 0,15254677 ! cerebral cortex development GO:0021987 36 19 0,000 0,11894337 0,1524655 ! pigmentation during development GO:0048066 41 19 0,000 0,11894337 0,15238431 ! response to vitamin A GO:0033189 27 19 0,000 0,11894337 0,15230321 ! heme metabolic process GO:0042168 36 19 0,000 0,11894337 0,1522222 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,11894337 0,15214127 ! plasma membrane fusion GO:0045026 28 19 0,000 0,11894337 0,15206043 ! regulation of endothelial cell migration GO:0010594 44 19 0,000 0,11894337 0,15197968 ! peptide cross-linking GO:0018149 37 19 0,000 0,11894337 0,15189901 ! protein export from nucleus GO:0006611 36 19 0,000 0,11894337 0,15181843 ! heart process GO:0003015 30 19 0,000 0,11894337 0,15173793 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,11894337 0,15165752 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,11894337 0,15157719 ! visual learning GO:0008542 36 19 0,000 0,11894337 0,15149695 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,11894337 0,15141679 ! cell-cell junction organization GO:0045216 35 19 0,000 0,11894337 0,15133672 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,11894337 0,15125673 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,11894337 0,15117683 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,11894337 0,15109701 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,11894337 0,15101728 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,11894337 0,15093763 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,11894337 0,15085806 ! cilium assembly GO:0042384 37 19 0,000 0,11894337 0,15077858 ! peptide hormone secretion GO:0030072 31 19 0,000 0,11894337 0,15069918 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,12048925 0,15257744 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,12479795 0,15795048 ! positive regulation of ossification GO:0045778 47 20 0,000 0,12479795 0,15786744 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,12479795 0,15778448 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,12479795 0,15770161 ! cAMP metabolic process GO:0046058 36 20 0,000 0,12479795 0,15761883 ! response to vitamin GO:0033273 31 20 0,000 0,12479795 0,15753613 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,12479795 0,15745352 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,12479795 0,157371 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,12479795 0,15728857 ! retinoid metabolic process GO:0001523 32 20 0,000 0,12479795 0,15720622 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,12479795 0,15712395 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,12479795 0,15704177 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,12479795 0,15695968 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,12479795 0,15687768 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,12479795 0,15679576 ! body fluid secretion GO:0007589 31 20 0,000 0,12479795 0,15671392 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,12479795 0,15663217 ! peptide secretion GO:0002790 35 20 0,000 0,12479795 0,15655051 ! stem cell differentiation GO:0048863 53 20 0,000 0,12479795 0,15646893 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,12479795 0,15638743 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,12479795 0,15630602 ! sensory perception of pain GO:0019233 30 20 0,000 0,12479795 0,1562247 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,12479795 0,15614346 ! diencephalon development GO:0021536 34 20 0,000 0,12479795 0,1560623 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,12479795 0,15598123 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,12479795 0,15590024 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,12479795 0,15581934 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,12479795 0,15573852 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,12479795 0,15565779 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,12479795 0,15557714 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,12479795 0,15549657 ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,12479795 0,15541608 ! regulation of glucose import GO:0046324 29 20 0,000 0,12479795 0,15533568 GO:0010827|regulation of glucose transport, ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,12479795 0,15525536 ! actin filament-based movement GO:0030048 43 20 0,000 0,12479795 0,15517513 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,12479795 0,15509497 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,12479795 0,15501491 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,12479795 0,15493492 ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,1270993 0,15771063 ! negative regulation of multicellular organismal process GO:0051241 166 93 1,000 0,1270993 0,15762934 ! female pregnancy GO:0007565 164 94 1,000 0,12932155 0,16030275 ! regulation of cell killing GO:0031341 42 21 0,000 0,13061383 0,16182125 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,13061383 0,16173797 ! hormone secretion GO:0046879 38 21 0,000 0,13061383 0,16165477 ! glycerol metabolic process GO:0006071 34 21 0,000 0,13061383 0,16157165 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,13061383 0,16148863 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,13061383 0,16140568 ! axis specification GO:0009798 38 21 0,000 0,13061383 0,16132283 ! inactivation of MAPK activity GO:0000188 39 21 0,000 0,13061383 0,16124006 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,13061383 0,16115737 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,13061383 0,16107477 ! cytolysis GO:0019835 24 21 0,000 0,13061383 0,16099225 ! vasodilation GO:0042311 39 21 0,000 0,13061383 0,16090981 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,13061383 0,16082747 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,13061383 0,1607452 ! positive regulation of locomotion GO:0040017 39 21 0,000 0,13061383 0,16066302 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 59 21 0,000 0,13061383 0,16058092 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,13061383 0,16049891 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,13061383 0,16041698 ! positive regulation of inflammatory response GO:0050729 35 21 0,000 0,13061383 0,16033514 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,13061383 0,16025337 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,13061383 0,1601717 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,13061383 0,1600901 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,13061383 0,16000859 ! collagen catabolic process GO:0030574 28 21 0,000 0,13061383 0,15992716 ! sperm-egg recognition GO:0035036 21 21 0,000 0,13061383 0,15984581 ! forebrain development GO:0030900 188 95 1,000 0,13155288 0,16091318 ! detection of stimulus GO:0051606 151 96 1,000 0,13379307 0,16357019 ! protein ubiquitination GO:0016567 217 97 1,000 0,13604192 0,16623507 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,13639125 0,16657733 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,13639125 0,16649282 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,13639125 0,16640839 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,13639125 0,16632405 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 40 22 0,000 0,13639125 0,16623979 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,13639125 0,16615562 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,13639125 0,16607153 ! keratinization GO:0031424 28 22 0,000 0,13639125 0,16598753 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,13639125 0,16590361 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,13639125 0,16581978 ! sensory perception of taste GO:0050909 28 22 0,000 0,13639125 0,16573603 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,13639125 0,16565237 ! vacuolar transport GO:0007034 36 22 0,000 0,13639125 0,16556879 ! lysosome organization GO:0007040 41 22 0,000 0,13639125 0,1654853 ! fucose metabolic process GO:0006004 39 22 0,000 0,13639125 0,16540189 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,13639125 0,16531856 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,13639125 0,16523532 GO:0060415|muscle tissue morphogenesis, ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,13639125 0,16515216 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,13639125 0,16506908 ! sarcomere organization GO:0045214 30 22 0,000 0,13639125 0,16498609 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,13639125 0,16490319 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,13639125 0,16482036 ! response to virus GO:0009615 160 98 1,000 0,1382992 0,16704211 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 1,000 0,14056472 0,16969328 ! Golgi vesicle transport GO:0048193 207 99 1,000 0,14056472 0,16960818 ! positive regulation of DNA replication GO:0045740 43 23 0,000 0,14213046 0,17141148 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,14213046 0,1713256 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,14213046 0,17123981 ! gluconeogenesis GO:0006094 33 23 0,000 0,14213046 0,1711541 ! viral genome replication GO:0019079 41 23 0,000 0,14213046 0,17106848 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,14213046 0,17098295 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,14213046 0,1708975 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,14213046 0,17081214 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,14213046 0,17072686 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,14213046 0,17064167 ! visual behavior GO:0007632 42 23 0,000 0,14213046 0,17055656 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,14213046 0,17047153 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,14213046 0,1703866 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,14213046 0,17030174 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,14213046 0,17021697 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,14213046 0,17013229 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,14213046 0,17004769 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,14213046 0,16996317 GO:0051693|actin filament capping, ! sex determination GO:0007530 47 23 0,000 0,14213046 0,16987874 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,14213046 0,16979439 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,14213046 0,16971012 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,14213046 0,16962594 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,14213046 0,16954184 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,14213046 0,16945783 ! platelet activation GO:0030168 37 23 0,000 0,14213046 0,1693739 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,14213046 0,16929005 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,14213046 0,16920628 ! hormone transport GO:0009914 40 23 0,000 0,14213046 0,1691226 ! cell-cell recognition GO:0009988 25 23 0,000 0,14213046 0,169039 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,14213046 0,16895548 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,14213046 0,16887205 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,14213046 0,1687887 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,14213046 0,16870543 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,14783173 0,17538617 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 52 24 0,000 0,14783173 0,17529973 ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,14783173 0,17521337 ! vesicle docking GO:0048278 47 24 0,000 0,14783173 0,1751271 ! spinal cord development GO:0021510 47 24 0,000 0,14783173 0,17504092 ! vacuole organization GO:0007033 43 24 0,000 0,14783173 0,17495482 ! digestive system process GO:0022600 39 24 0,000 0,14783173 0,1748688 ! regulation of behavior GO:0050795 43 24 0,000 0,14783173 0,17478287 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,14783173 0,17469703 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,14783173 0,17461126 ! membrane depolarization GO:0051899 39 24 0,000 0,14783173 0,17452559 ! pallium development GO:0021543 49 24 0,000 0,14783173 0,17443999 ! pentose metabolic process GO:0019321 35 24 0,000 0,14783173 0,17435448 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,14783173 0,17426906 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,14783173 0,17418371 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,14783173 0,17409846 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,14783173 0,17401328 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,14783173 0,17392819 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,14783173 0,17384318 ! regulation of amine transport GO:0051952 40 24 0,000 0,14783173 0,17375825 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,1534953 0,18032699 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,1534953 0,18023899 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,1534953 0,18015106 ! phototransduction GO:0007602 33 25 0,000 0,1534953 0,18006323 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,1534953 0,17997548 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,1534953 0,17988781 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,1534953 0,17980023 ! chromosome condensation GO:0030261 45 25 0,000 0,1534953 0,17971274 ! neural crest cell development GO:0014032 54 25 0,000 0,1534953 0,17962533 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,1534953 0,17953801 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,1534953 0,17945077 ! interaction with host GO:0051701 62 25 0,000 0,1534953 0,17936361 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,1534953 0,17927654 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,1534953 0,17918956 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! immunoglobulin production GO:0002377 55 25 0,000 0,1534953 0,17910266 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,1534953 0,17901584 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,1534953 0,17892911 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,1534953 0,17884246 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,1534953 0,1787559 ! telomere organization GO:0032200 43 25 0,000 0,1534953 0,17866942 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,1534953 0,17858302 GO:0060606|tube closure, ! liver development GO:0001889 53 25 0,000 0,1534953 0,1784967 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,15912141 0,18494981 ! embryonic pattern specification GO:0009880 44 26 0,000 0,15912141 0,1848605 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,15912141 0,18477129 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,15912141 0,18468215 ! initiation of viral infection GO:0019059 57 26 0,000 0,15912141 0,18459311 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,15912141 0,18450415 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,15912141 0,18441527 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,15912141 0,18432648 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,15912141 0,18423778 ! tube lumen formation GO:0035148 50 26 0,000 0,15912141 0,18414916 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,15912141 0,18406063 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,15912141 0,18397218 ! regulation of endothelial cell proliferation GO:0001936 57 26 0,000 0,15912141 0,18388382 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 0,000 0,15912141 0,18379554 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,15912141 0,18370734 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,15912141 0,18361924 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,15912141 0,18353121 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,15912141 0,18344327 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,15912141 0,18335541 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,15912141 0,18326764 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,15912141 0,18317995 ! neuron fate commitment GO:0048663 48 27 0,000 0,16471031 0,1895232 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 0,000 0,16471031 0,1894326 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,16471031 0,1893421 ! iron ion transport GO:0006826 59 27 0,000 0,16471031 0,18925168 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,16471031 0,18916134 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,16471031 0,18907109 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,16471031 0,18898093 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,16471031 0,18889085 ! autophagy GO:0006914 41 27 0,000 0,16471031 0,18880086 ! primary neural tube formation GO:0014020 51 27 0,000 0,16471031 0,18871096 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,16471031 0,18862114 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,16471031 0,1885314 ! glutathione metabolic process GO:0006749 39 27 0,000 0,16471031 0,18844175 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,16471031 0,18835219 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,16471031 0,18826271 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,16471031 0,18817332 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,17026225 0,19442382 ! circadian rhythm GO:0007623 50 28 0,000 0,17026225 0,19433159 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,17026225 0,19423944 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,17026225 0,19414738 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,17026225 0,19405542 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,17026225 0,19396353 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,17026225 0,19387174 ! synaptogenesis GO:0007416 42 28 0,000 0,17026225 0,19378003 ! peptidyl-tyrosine modification GO:0018212 50 28 0,000 0,17026225 0,19368841 ! lipid oxidation GO:0034440 43 28 0,000 0,17026225 0,19359687 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,17026225 0,19350542 ! translational initiation GO:0006413 65 29 0,000 0,17577748 0,19967923 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,17577748 0,199585 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,17577748 0,19949085 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,17577748 0,1993968 ! catechol metabolic process GO:0009712 54 29 0,000 0,17577748 0,19930283 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,17577748 0,19920895 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,17577748 0,19911516 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,17577748 0,19902146 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,17577748 0,19892785 ! cell fate determination GO:0001709 60 29 0,000 0,17577748 0,19883432 ! detection of light stimulus GO:0009583 38 29 0,000 0,17577748 0,19874089 ! regulation of coagulation GO:0050818 46 29 0,000 0,17577748 0,19864754 ! phenol metabolic process GO:0018958 55 30 0,000 0,18125622 0,20474294 ! zinc ion transport GO:0006829 45 30 0,000 0,18125622 0,20464687 ! membrane docking GO:0022406 61 30 0,000 0,18125622 0,20455088 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,18125622 0,20445498 ! regulation of innate immune response GO:0045088 51 30 0,000 0,18125622 0,20435917 ! acute-phase response GO:0006953 49 30 0,000 0,18125622 0,20426345 ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,18125622 0,20416782 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,18125622 0,20407228 ! phospholipid transport GO:0015914 51 30 0,000 0,18125622 0,20397683 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,18125622 0,20388147 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,18125622 0,2037862 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,18125622 0,20369102 ! eye morphogenesis GO:0048592 60 30 0,000 0,18125622 0,20359592 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,18669873 0,20961136 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,18669873 0,20951359 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,18669873 0,20941592 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,18669873 0,20931833 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,18669873 0,20922084 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,18669873 0,20912344 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,18669873 0,20902613 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,18669873 0,20892891 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,18669873 0,20883177 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,18669873 0,20873473 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,18669873 0,20863778 ! peptide transport GO:0015833 55 31 0,000 0,18669873 0,20854092 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,18669873 0,20844415 ! mesoderm formation GO:0001707 69 31 0,000 0,18669873 0,20834747 ! natural killer cell activation GO:0030101 45 31 0,000 0,18669873 0,20825088 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,18669873 0,20815438 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,18669873 0,20805797 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,18669873 0,20796164 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,19210524 0,21388487 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,19210524 0,21378594 ! cholesterol transport GO:0030301 56 32 0,000 0,19210524 0,21368711 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,19210524 0,21358836 ! spliceosome assembly GO:0000245 67 32 0,000 0,19210524 0,2134897 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,19210524 0,21339114 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,19210524 0,21329267 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,19210524 0,21319428 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,19210524 0,21309599 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,19210524 0,21299779 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,19210524 0,21289968 ! negative regulation of MAP kinase activity GO:0043407 69 32 0,000 0,19210524 0,21280166 ! BMP signaling pathway GO:0030509 64 32 0,000 0,19210524 0,21270373 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,19210524 0,21260589 ! gene silencing GO:0016458 65 32 0,000 0,19210524 0,21250814 ! protein targeting to membrane GO:0006612 68 33 0,000 0,19747599 0,21834891 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,19747599 0,21824861 ! ceramide metabolic process GO:0006672 64 33 0,000 0,19747599 0,21814841 ! formation of primary germ layer GO:0001704 72 33 0,000 0,19747599 0,21804829 ! cell fate specification GO:0001708 52 33 0,000 0,19747599 0,21794827 ! sterol transport GO:0015918 57 33 0,000 0,19747599 0,21784834 ! leukocyte chemotaxis GO:0030595 50 33 0,000 0,19747599 0,2177485 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,19747599 0,21764875 ! adult locomotory behavior GO:0008344 59 33 0,000 0,19747599 0,2175491 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,19747599 0,21744953 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,20281121 0,22322222 ! glial cell differentiation GO:0010001 63 34 0,000 0,20281121 0,22312015 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,20281121 0,22301818 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,20281121 0,2229163 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,20281121 0,22281451 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,20281121 0,22271281 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,20281121 0,22261121 ! mismatch repair GO:0006298 46 34 0,000 0,20281121 0,2225097 ! spermatid development GO:0007286 63 34 0,000 0,20281121 0,22240828 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,20281121 0,22230696 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,20281121 0,22220572 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 0,000 0,20281121 0,22210458 ! negative regulation of secretion GO:0051048 63 35 0,000 0,20811114 0,227805 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,20811114 0,22770141 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,20811114 0,22759791 GO:0006639|acylglycerol metabolic process, ! telencephalon development GO:0021537 68 35 0,000 0,20811114 0,2274945 ! cytokine production GO:0001816 59 35 0,000 0,20811114 0,22739119 ! neural tube formation GO:0001841 67 35 0,000 0,20811114 0,22728797 ! vesicle localization GO:0051648 64 35 0,000 0,20811114 0,22718485 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,21337601 0,23282661 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,21337601 0,23272107 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,21337601 0,23261562 ! regulation of proteolysis GO:0030162 72 36 0,000 0,21337601 0,23251027 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,21337601 0,23240501 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,21337601 0,23229985 ! aerobic respiration GO:0009060 55 36 0,000 0,21337601 0,23219479 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,21337601 0,23208982 ! RNA export from nucleus GO:0006405 56 37 0,000 0,21860605 0,2376711 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,21860605 0,23756375 ! organic anion transport GO:0015711 68 37 0,000 0,21860605 0,2374565 ! tissue remodeling GO:0048771 76 37 0,000 0,21860605 0,23734934 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,21860605 0,23724229 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,21860605 0,23713532 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,21860605 0,23702846 GO:0015986|ATP synthesis coupled proton transport, ! glycogen metabolic process GO:0005977 61 37 0,000 0,21860605 0,23692169 ! spermatid differentiation GO:0048515 66 37 0,000 0,21860605 0,23681501 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,22380148 0,2423341 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,22380148 0,24222509 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,22380148 0,24211617 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,22380148 0,24200736 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,22380148 0,24189864 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,22380148 0,24179002 ! embryonic epithelial tube formation GO:0001838 72 38 0,000 0,22380148 0,2416815 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,22380148 0,24157307 ! glucan metabolic process GO:0044042 62 38 0,000 0,22380148 0,24146474 GO:0006073|cellular glucan metabolic process, ! mRNA catabolic process GO:0006402 71 39 0,000 0,22896255 0,24692241 ! learning GO:0007612 77 39 0,000 0,22896255 0,24681178 ! organic ether metabolic process GO:0018904 55 39 0,000 0,22896255 0,24670125 ! ion transmembrane transport GO:0034220 66 39 0,000 0,22896255 0,24659082 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,22896255 0,24648049 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,22896255 0,24637026 ! RNA modification GO:0009451 57 39 0,000 0,22896255 0,24626012 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,22896255 0,24615009 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,23408947 0,25154947 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,23408947 0,25143717 ! multicellular organismal metabolic process GO:0044236 57 40 0,000 0,23408947 0,25132497 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,23408947 0,25121288 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,23918247 0,25656399 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,23918247 0,25644965 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,23918247 0,25633542 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,23918247 0,25622129 ! gliogenesis GO:0042063 88 41 0,000 0,23918247 0,25610726 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,23918247 0,25599334 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,23918247 0,25587951 ! polyol metabolic process GO:0019751 66 41 0,000 0,23918247 0,25576579 ! dorsal/ventral pattern formation GO:0009953 68 41 0,000 0,23918247 0,25565216 ! regulation of tube size GO:0035150 71 42 0,000 0,24424177 0,26094391 GO:0050880|regulation of blood vessel size, ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,24424177 0,26082809 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,24424177 0,26071238 ! neuron migration GO:0001764 79 42 0,000 0,24424177 0,26059676 ! regulation of protein secretion GO:0050708 71 42 0,000 0,24424177 0,26048125 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,24926759 0,26572345 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,24926759 0,26560577 ! positive regulation of response to external stimulus GO:0032103 77 43 0,000 0,24926759 0,26548819 ! neural tube development GO:0021915 77 43 0,000 0,24926759 0,26537072 ! phagocytosis GO:0006909 90 43 0,000 0,24926759 0,26525335 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,24926759 0,26513609 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,25426016 0,27032698 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,25426016 0,27020757 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,25426016 0,27008828 ! JAK-STAT cascade GO:0007259 71 44 0,000 0,25426016 0,26996908 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,25921969 0,27511362 ! leukocyte migration GO:0050900 68 45 0,000 0,25921969 0,27499232 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,25921969 0,27487112 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,25921969 0,27475003 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,25921969 0,27462905 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,25921969 0,27450818 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,25921969 0,27438741 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,2641464 0,27947944 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,2641464 0,27935659 ! positive regulation of defense response GO:0031349 76 47 0,000 0,26904051 0,2844075 ! vascular process in circulatory system GO:0003018 80 47 0,000 0,26904051 0,28428259 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,26904051 0,2841578 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,26904051 0,28403311 ! Notch signaling pathway GO:0007219 96 48 0,000 0,27390223 0,28903893 ! morphogenesis of embryonic epithelium GO:0016331 91 48 0,000 0,27390223 0,28891222 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,27390223 0,28878561 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,27390223 0,28865912 ! regulation of inflammatory response GO:0050727 75 48 0,000 0,27390223 0,28853273 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,27873177 0,29349175 ! regulation of ion transport GO:0043269 77 49 0,000 0,27873177 0,29336336 ! induction of apoptosis by extracellular signals GO:0008624 89 49 0,000 0,27873177 0,29323509 ! peptide metabolic process GO:0006518 76 49 0,000 0,27873177 0,29310693 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,27873177 0,29297888 ! endocrine system development GO:0035270 104 49 0,000 0,27873177 0,29285094 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,27873177 0,29272311 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,27873177 0,2925954 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,28352935 0,2975018 ! neuromuscular process GO:0050905 99 50 0,000 0,28352935 0,29737211 ! inner ear development GO:0048839 79 50 0,000 0,28352935 0,29724254 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,28352935 0,29711308 ! viral infectious cycle GO:0019058 99 51 0,000 0,28829518 0,30197571 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,28829518 0,3018443 ! excretion GO:0007588 83 51 0,000 0,28829518 0,30171301 ! chromatin remodeling GO:0006338 109 51 0,000 0,28829518 0,30158183 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,28829518 0,30145076 ! regulation of cell shape GO:0008360 125 51 0,000 0,28829518 0,30131981 ! regulation of muscle contraction GO:0006937 81 52 0,000 0,29302946 0,30613499 ! membrane fusion GO:0006944 110 52 0,000 0,29302946 0,30600212 ! amino acid activation GO:0043038 92 52 0,000 0,29302946 0,30586937 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! cartilage development GO:0051216 90 52 0,000 0,29302946 0,30573673 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,29773241 0,31050896 ! RNA catabolic process GO:0006401 93 53 0,000 0,29773241 0,31037443 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,29773241 0,31024001 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,29773241 0,31010571 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,30240423 0,31483538 ! cell recognition GO:0008037 85 54 0,000 0,30240423 0,31469921 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,30240423 0,31456315 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,30240423 0,31442721 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,30240423 0,31429139 ! cellular polysaccharide metabolic process GO:0044264 86 55 0,000 0,30704512 0,31897693 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,30704512 0,31883926 ! gastrulation GO:0007369 112 55 0,000 0,30704512 0,31870171 ! heart morphogenesis GO:0003007 97 55 0,000 0,30704512 0,31856428 ! nuclear export GO:0051168 97 55 0,000 0,30704512 0,31842697 ! sensory perception of smell GO:0007608 80 56 0,000 0,31165529 0,32306878 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,31165529 0,32292964 ! proton transport GO:0015992 94 56 0,000 0,31165529 0,32279063 ! hydrogen transport GO:0006818 97 58 0,000 0,32078428 0,33210283 ! regulation of endocytosis GO:0030100 91 58 0,000 0,32078428 0,33195999 ! positive regulation of secretion GO:0051047 95 59 0,000 0,3253035 0,33649192 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,3253035 0,33634732 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,3253035 0,33620284 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,32979279 0,34069621 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,32979279 0,34054998 ! regulation of heart contraction GO:0008016 110 60 0,000 0,32979279 0,34040389 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,33425237 0,34485901 ! mesoderm development GO:0007498 119 61 0,000 0,33425237 0,34471119 ! tRNA processing GO:0008033 89 61 0,000 0,33425237 0,3445635 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,33425237 0,34441593 ! viral reproductive process GO:0022415 126 62 0,000 0,33868242 0,34883129 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,33868242 0,34868203 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,34308313 0,3530616 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,34308313 0,35291065 ! cell redox homeostasis GO:0045454 102 64 0,000 0,34745471 0,35725472 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,34745471 0,35710211 ! single fertilization GO:0007338 75 64 0,000 0,34745471 0,35694963 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,35179734 0,36125668 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,35179734 0,36110256 ! embryonic limb morphogenesis GO:0030326 125 65 0,000 0,35179734 0,36094857 GO:0035113|embryonic appendage morphogenesis, ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,36039652 0,36961382 ! adaptive immune response GO:0002250 119 67 0,000 0,36039652 0,36945634 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 0,000 0,36039652 0,36929899 ! amino acid transport GO:0006865 125 68 0,000 0,36465345 0,373502 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,36465345 0,37334306 ! viral reproduction GO:0016032 134 68 0,000 0,36465345 0,37318426 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,36465345 0,37302559 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,36888219 0,37719105 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,36888219 0,37703082 ! antigen processing and presentation GO:0019882 104 69 0,000 0,36888219 0,37687072 ! appendage morphogenesis GO:0035107 135 70 0,000 0,37308292 0,38100064 GO:0035108|limb morphogenesis, ! amine catabolic process GO:0009310 117 71 0,000 0,37725583 0,38509865 ! appendage development GO:0048736 136 71 0,000 0,37725583 0,38493533 GO:0060173|limb development, ! regulation of immune effector process GO:0002697 137 71 0,000 0,37725583 0,38477216 ! acute inflammatory response GO:0002526 113 72 0,000 0,3814011 0,38883519 ! learning or memory GO:0007611 147 73 0,000 0,38551891 0,3928668 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,38551891 0,39270047 ! fertilization GO:0009566 90 73 0,000 0,38551891 0,39253428 ! transition metal ion transport GO:0000041 126 74 0,000 0,38960946 0,39653145 ! neurotransmitter transport GO:0006836 123 74 0,000 0,38960946 0,39636378 ! exocytosis GO:0006887 133 74 0,000 0,38960946 0,39619626 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,38960946 0,39602888 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,3936729 0,39999029 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,3936729 0,39982144 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,39770943 0,40375059 ! defense response to bacterium GO:0042742 89 76 0,000 0,39770943 0,4035803 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,40171922 0,40747742 ! blood coagulation GO:0007596 146 78 0,000 0,40570245 0,41134433 GO:0050817|coagulation, ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,40965929 0,41518123 ! regulation of synaptic transmission GO:0050804 134 79 0,000 0,40965929 0,41500642 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,41358991 0,41881201 ! digestion GO:0007586 112 81 0,000 0,4174945 0,42258804 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,4174945 0,42241033 ! hemostasis GO:0007599 158 84 0,000 0,42905372 0,43392318 ! regulation of transmission of nerve impulse GO:0051969 141 84 0,000 0,42905372 0,43374086 ! nucleosome assembly GO:0006334 122 85 0,000 0,43285585 0,43740074 ! amine biosynthetic process GO:0009309 138 86 0,000 0,43663278 0,4410321 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,43663278 0,44084703 ! chromatin assembly GO:0031497 124 86 0,000 0,43663278 0,44066211 ! amine transport GO:0015837 155 86 0,000 0,43663278 0,44047734 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,44038468 0,44407609 ! cellular respiration GO:0045333 135 88 0,000 0,44411172 0,44764676 ! regulation of neurological system process GO:0031644 148 88 0,000 0,44411172 0,4474593 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,44411172 0,447272 ! cellular defense response GO:0006968 114 89 0,000 0,44781407 0,45081199 ! regulation of cell morphogenesis GO:0022604 215 89 0,000 0,44781407 0,45062344 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,45149187 0,45413438 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,45514531 0,45761789 ! regulation of defense response GO:0031347 149 92 0,000 0,45877453 0,46107415 ! nucleosome organization GO:0034728 138 92 0,000 0,45877453 0,46088163 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,45877453 0,46068928 ! vitamin metabolic process GO:0006766 139 92 0,000 0,45877453 0,46049708 ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,46237969 0,46392224 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,46596096 0,46732058 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,46951849 0,47069229 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,47305245 0,47403756 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,47305245 0,47384021 ! positive regulation of immune response GO:0050778 156 96 0,000 0,47305245 0,47364302 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,47656297 0,47695945 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,48005023 0,48024983 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,48005023 0,48005023 GO:0016054|organic acid catabolic process,