pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6427-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 224 98 12,000 2,541E-14 6,207E-11 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 8,000 5,197E-11 6,349E-08 ! apoptotic mitochondrial changes GO:0008637 42 20 5,000 1,432E-09 1,166E-06 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 5,000 6,385E-09 3,9E-06 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 6,000 1,001E-08 4,89E-06 ! response to UV GO:0009411 120 55 6,000 3,627E-08 1,477E-05 ! regulation of DNA metabolic process GO:0051052 188 97 7,000 1,196E-07 4,175E-05 ! G1 phase GO:0051318 44 22 4,000 1,665E-07 5,086E-05 ! meiosis GO:0007126 143 81 6,000 5,458E-07 1,482E-04 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 144 82 6,000 5,938E-07 1,451E-04 ! regulation of DNA replication GO:0006275 105 56 5,000 1,005E-06 2,232E-04 ! nucleotide-excision repair GO:0006289 91 57 5,000 1,118E-06 2,276E-04 ! response to gamma radiation GO:0010332 30 14 3,000 1,132E-06 2,126E-04 ! release of cytochrome c from mitochondria GO:0001836 31 14 3,000 1,132E-06 1,975E-04 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 2,000 2,015E-06 3,282E-04 ! response to peptide hormone stimulus GO:0043434 129 64 5,000 2,231E-06 3,407E-04 ! androgen receptor signaling pathway GO:0030521 81 37 4,000 2,565E-06 3,686E-04 ! negative regulation of cell growth GO:0030308 142 67 5,000 2,927E-06 3,972E-04 ! meiosis I GO:0007127 74 38 4,000 2,94E-06 3,78E-04 ! regulation of protein stability GO:0031647 77 38 4,000 2,94E-06 3,591E-04 ! negative regulation of cell size GO:0045792 144 69 5,000 3,481E-06 4,05E-04 ! cell cycle checkpoint GO:0000075 145 71 5,000 4,118E-06 4,573E-04 ! G1 phase of mitotic cell cycle GO:0000080 39 19 3,000 4,281E-06 4,547E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 4,000 6,919E-06 7,043E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 6,919E-06 6,761E-04 ! centrosome duplication GO:0051298 14 7 2,000 6,993E-06 6,57E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 6,993E-06 6,327E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 6,993E-06 6,101E-04 ! reciprocal meiotic recombination GO:0007131 44 22 3,000 7,968E-06 6,712E-04 ! cell aging GO:0007569 48 22 3,000 7,968E-06 6,488E-04 ! response to insulin stimulus GO:0032868 98 47 4,000 8,604E-06 6,78E-04 ! positive regulation of cell cycle GO:0045787 96 48 4,000 9,558E-06 7,297E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 2,000 1,114E-05 8,246E-04 ! male meiosis GO:0007140 9 8 2,000 1,114E-05 8,004E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,114E-05 7,775E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,114E-05 7,559E-04 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 3,000 1,147E-05 7,572E-04 ! negative regulation of growth GO:0045926 168 85 5,000 1,174E-05 7,549E-04 ! mitochondrion organization GO:0007005 159 87 5,000 1,343E-05 8,41E-04 ! negative regulation of DNA replication GO:0008156 45 25 3,000 1,359E-05 8,299E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 2,366E-05 1,41E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 2,366E-05 1,376E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 2,000 2,366E-05 1,344E-03 ! aging GO:0007568 112 58 4,000 2,438E-05 1,354E-03 ! oocyte development GO:0048599 20 11 2,000 3,239E-05 1,759E-03 ! DNA damage response, signal transduction GO:0042770 136 62 4,000 3,378E-05 1,794E-03 ! integrin-mediated signaling pathway GO:0007229 160 64 4,000 3,942E-05 2,049E-03 ! response to ionizing radiation GO:0010212 74 33 3,000 4,236E-05 2,156E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 4,3E-05 2,144E-03 ! focal adhesion formation GO:0048041 37 12 2,000 4,3E-05 2,101E-03 ! oocyte differentiation GO:0009994 21 12 2,000 4,3E-05 2,06E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 4,3E-05 2,02E-03 GO:0042130|negative regulation of T cell proliferation, ! steroid hormone receptor signaling pathway GO:0030518 146 66 4,000 4,577E-05 2,11E-03 ! DNA damage checkpoint GO:0000077 78 35 3,000 5,37E-05 2,43E-03 ! negative regulation of DNA metabolic process GO:0051053 65 35 3,000 5,37E-05 2,385E-03 ! double-strand break repair via homologous recombination GO:0000724 19 13 2,000 5,566E-05 2,428E-03 GO:0000725|recombinational repair, ! response to X-ray GO:0010165 28 13 2,000 5,566E-05 2,386E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 4,000 5,673E-05 2,39E-03 ! negative regulation of kinase activity GO:0033673 145 70 4,000 6,08E-05 2,518E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 4,000 6,51E-05 2,651E-03 ! DNA integrity checkpoint GO:0031570 82 38 3,000 7,467E-05 2,99E-03 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 7,467E-05 2,942E-03 ! negative regulation of transferase activity GO:0051348 155 74 4,000 7,94E-05 3,079E-03 ! negative regulation of binding GO:0051100 71 39 3,000 8,281E-05 3,161E-03 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 2,000 1,076E-04 4,043E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,076E-04 3,982E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 4,000 1,085E-04 3,955E-03 ! regulation of T cell differentiation GO:0045580 78 42 3,000 1,111E-04 3,993E-03 ! regulation of protein binding GO:0043393 33 17 2,000 1,3E-04 4,604E-03 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 1,3E-04 4,539E-03 ! double-strand break repair GO:0006302 85 44 3,000 1,336E-04 4,596E-03 ! regulation of ligase activity GO:0051340 147 84 4,000 1,451E-04 4,922E-03 ! branching morphogenesis of a tube GO:0048754 102 45 3,000 1,459E-04 4,883E-03 ! centrosome cycle GO:0007098 26 18 2,000 1,554E-04 5,13E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 1,554E-04 5,061E-03 ! negative regulation of cell migration GO:0030336 122 46 3,000 1,591E-04 5,114E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 2,037E-04 6,463E-03 ! regulation of mast cell proliferation GO:0070666 89 49 3,000 2,037E-04 6,38E-03 ! gland development GO:0048732 220 91 4,000 2,113E-04 6,536E-03 ! response to alkaloid GO:0043279 38 20 2,000 2,152E-04 6,571E-03 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 2,000 2,152E-04 6,49E-03 ! negative regulation of T cell activation GO:0050868 41 20 2,000 2,152E-04 6,411E-03 ! activation of caspase activity GO:0006919 95 50 3,000 2,204E-04 6,487E-03 ! regulation of cell adhesion GO:0030155 241 92 4,000 2,224E-04 6,469E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 2,5E-04 7,184E-03 ! DNA-dependent DNA replication GO:0006261 82 52 3,000 2,567E-04 7,292E-03 ! morphogenesis of a branching structure GO:0001763 116 52 3,000 2,567E-04 7,209E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 3,000 2,764E-04 7,673E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 2,000 2,882E-04 7,91E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 2,882E-04 7,822E-03 ! protein stabilization GO:0050821 41 22 2,000 2,882E-04 7,736E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 2,985E-04 7,926E-03 ! cell maturation GO:0048469 107 55 3,000 3,19E-04 8,379E-03 ! negative regulation of cell motion GO:0051271 142 55 3,000 3,19E-04 8,29E-03 ! regulation of cell-matrix adhesion GO:0001952 81 23 2,000 3,3E-04 8,485E-03 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 3,3E-04 8,397E-03 ! negative regulation of protein ubiquitination GO:0031397 10 5 1,000 3,434E-04 8,648E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 3,434E-04 8,56E-03 GO:0045844|positive regulation of striated muscle development, ! skeletal myofibril assembly GO:0014866 12 5 1,000 3,434E-04 8,473E-03 ! cardiac muscle fiber development GO:0048739 12 5 1,000 3,434E-04 8,388E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 3,434E-04 8,305E-03 ! microvillus organization GO:0032528 8 5 1,000 3,434E-04 8,224E-03 GO:0030033|microvillus assembly, ! regulation of response to food GO:0032095 7 5 1,000 3,434E-04 8,144E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 3,434E-04 8,066E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 3,434E-04 7,989E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 3,434E-04 7,914E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 3,434E-04 7,84E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 3,434E-04 7,767E-03 ! mitotic recombination GO:0006312 9 5 1,000 3,434E-04 7,696E-03 ! regulation of sterol transport GO:0032371 7 5 1,000 3,434E-04 7,626E-03 GO:0032374|regulation of cholesterol transport, ! B cell homeostasis GO:0001782 13 5 1,000 3,434E-04 7,557E-03 ! inner cell mass cell proliferation GO:0001833 5 5 1,000 3,434E-04 7,49E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 3,434E-04 7,423E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 3,434E-04 7,358E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 3,434E-04 7,294E-03 ! receptor biosynthetic process GO:0032800 7 5 1,000 3,434E-04 7,231E-03 ! stem cell division GO:0017145 11 5 1,000 3,434E-04 7,17E-03 GO:0048103|somatic stem cell division, ! positive regulation of caspase activity GO:0043280 108 57 3,000 3,66E-04 7,578E-03 GO:0010952|positive regulation of peptidase activity, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 3,755E-04 7,708E-03 ! negative regulation of phosphorylation GO:0042326 52 24 2,000 3,755E-04 7,644E-03 ! oogenesis GO:0048477 44 24 2,000 3,755E-04 7,581E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 3,755E-04 7,518E-03 ! positive regulation of cell migration GO:0030335 137 58 3,000 3,913E-04 7,773E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 4,248E-04 8,369E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 4,248E-04 8,302E-03 ! receptor metabolic process GO:0043112 53 25 2,000 4,248E-04 8,236E-03 ! DNA catabolic process GO:0006308 94 60 3,000 4,457E-04 8,573E-03 ! microtubule organizing center organization GO:0031023 42 26 2,000 4,781E-04 9,125E-03 GO:0051297|centrosome organization, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 2,000 4,781E-04 9,055E-03 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 2,000 4,781E-04 8,985E-03 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 4,781E-04 8,917E-03 ! positive regulation of actin filament polymerization GO:0030838 11 6 1,000 5,13E-04 9,495E-03 ! negative regulation of cell-cell adhesion GO:0022408 13 6 1,000 5,13E-04 9,424E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 5,13E-04 9,353E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 5,13E-04 9,284E-03 ! activation of MAPKKK activity GO:0000185 12 6 1,000 5,13E-04 9,216E-03 ! regulation of appetite GO:0032098 10 6 1,000 5,13E-04 9,149E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 5,13E-04 9,082E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 5,13E-04 9,017E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! establishment of spindle localization GO:0051293 16 6 1,000 5,13E-04 8,953E-03 GO:0051653|spindle localization, ! neural nucleus development GO:0048857 19 6 1,000 5,13E-04 8,889E-03 ! response to UV-C GO:0010225 14 6 1,000 5,13E-04 8,826E-03 ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 5,13E-04 8,765E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 5,13E-04 8,704E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 5,13E-04 8,644E-03 GO:0043011|myeloid dendritic cell differentiation, ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 5,13E-04 8,585E-03 ! cytoplasmic microtubule organization GO:0031122 18 6 1,000 5,13E-04 8,526E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 5,13E-04 8,469E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 5,356E-04 8,781E-03 ! mitochondrial membrane organization GO:0007006 60 27 2,000 5,356E-04 8,722E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 5,356E-04 8,665E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 5,356E-04 8,608E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 5,701E-04 9,103E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 5,972E-04 9,474E-03 ! fat cell differentiation GO:0045444 57 28 2,000 5,972E-04 9,413E-03 ! base-excision repair GO:0006284 41 28 2,000 5,972E-04 9,353E-03 ! positive regulation of cell motion GO:0051272 157 65 3,000 6,047E-04 9,409E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 6,408E-04 9,907E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 6,632E-04 0,01019056 ! response to organic cyclic substance GO:0014070 58 29 2,000 6,632E-04 0,01012687 ! myeloid cell differentiation GO:0030099 126 67 3,000 6,783E-04 0,01029274 ! regulation of helicase activity GO:0051095 16 7 1,000 7,155E-04 0,01078928 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 7,155E-04 0,01072309 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 7,155E-04 0,0106577 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 7,155E-04 0,01059311 ! response to dietary excess GO:0002021 8 7 1,000 7,155E-04 0,0105293 ! positive regulation of mitotic cell cycle GO:0045931 14 7 1,000 7,155E-04 0,01046625 ! monocyte differentiation GO:0030224 16 7 1,000 7,155E-04 0,01040395 ! eating behavior GO:0042755 8 7 1,000 7,155E-04 0,01034238 ! prostate gland development GO:0030850 14 7 1,000 7,155E-04 0,01028155 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 7,155E-04 0,01022142 ! regulation of gluconeogenesis GO:0006111 8 7 1,000 7,155E-04 0,01016199 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 7,155E-04 0,01010325 ! lipoprotein transport GO:0042953 14 7 1,000 7,155E-04 0,01004519 ! organ growth GO:0035265 15 7 1,000 7,155E-04 9,988E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 7,155E-04 9,931E-03 ! regulation of lipid transport GO:0032368 14 7 1,000 7,155E-04 9,875E-03 ! peptidyl-threonine modification GO:0018210 26 7 1,000 7,155E-04 9,819E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 7,155E-04 9,765E-03 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 3,000 7,174E-04 9,737E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 7,337E-04 9,903E-03 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 2,000 7,337E-04 9,849E-03 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 2,000 7,337E-04 9,795E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 3,000 7,581E-04 0,01006497 ! developmental maturation GO:0021700 128 69 3,000 7,581E-04 0,01001056 ! cell junction assembly GO:0034329 85 31 2,000 8,088E-04 0,01062353 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 8,088E-04 0,01056672 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 8,088E-04 0,01051051 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 8,088E-04 0,0104549 ! actin filament organization GO:0007015 167 72 3,000 8,898E-04 0,01144072 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 3,000 8,898E-04 0,01138082 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 3,000 8,898E-04 0,01132155 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 9,502E-04 0,01202805 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 9,502E-04 0,01196605 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 9,502E-04 0,01190468 ! regulation of response to extracellular stimulus GO:0032104 14 8 1,000 9,502E-04 0,01184394 GO:0032107|regulation of response to nutrient levels, ! pigment granule organization GO:0048753 17 8 1,000 9,502E-04 0,01178382 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 9,502E-04 0,01172431 ! ER overload response GO:0006983 13 8 1,000 9,502E-04 0,01166539 ! regulation of pigmentation during development GO:0048070 25 8 1,000 9,502E-04 0,01160707 ! melanin metabolic process GO:0006582 17 8 1,000 9,502E-04 0,01154932 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 9,502E-04 0,01149214 ! response to UV-B GO:0010224 17 8 1,000 9,502E-04 0,01143553 ! response to tumor cell GO:0002347 16 8 1,000 9,502E-04 0,01137948 ! adult feeding behavior GO:0008343 10 8 1,000 9,502E-04 0,01132397 ! blastocyst growth GO:0001832 19 8 1,000 9,502E-04 0,011269 ! negative regulation of protein transport GO:0051224 74 33 2,000 9,733E-04 0,01148638 ! regulation of caspase activity GO:0043281 136 74 3,000 9,861E-04 0,01158146 ! regulation of transcription factor activity GO:0051090 137 75 3,000 1,037E-03 0,01211965 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 3,000 1,037E-03 0,01206194 ! cell-matrix adhesion GO:0007160 181 76 3,000 1,089E-03 0,01261369 ! regulation of endopeptidase activity GO:0052548 141 77 3,000 1,144E-03 0,01318148 ! positive regulation of ligase activity GO:0051351 130 77 3,000 1,144E-03 0,01311959 ! microtubule bundle formation GO:0001578 22 9 1,000 1,217E-03 0,01389281 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,217E-03 0,0138282 ! T cell selection GO:0045058 27 9 1,000 1,217E-03 0,01376418 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,217E-03 0,01370075 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 1,000 1,217E-03 0,0136379 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 1,217E-03 0,01357563 ! receptor clustering GO:0043113 20 9 1,000 1,217E-03 0,01351392 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 1,217E-03 0,01345277 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,217E-03 0,01339217 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 1,217E-03 0,01333212 ! regulation of telomere maintenance GO:0032204 17 9 1,000 1,217E-03 0,0132726 ! negative regulation of DNA binding GO:0043392 67 36 2,000 1,257E-03 0,01365023 ! negative regulation of cell adhesion GO:0007162 94 37 2,000 1,362E-03 0,01472492 ! cell junction organization GO:0034330 96 37 2,000 1,362E-03 0,01466005 ! female gonad development GO:0008585 71 37 2,000 1,362E-03 0,01459575 ! regulation of microtubule-based process GO:0032886 86 37 2,000 1,362E-03 0,01453201 ! negative regulation of cell activation GO:0050866 69 37 2,000 1,362E-03 0,01446883 ! regulation of peptidase activity GO:0052547 150 82 3,000 1,445E-03 0,01528093 ! cell-substrate adhesion GO:0031589 189 82 3,000 1,445E-03 0,01521506 ! response to drug GO:0042493 149 83 3,000 1,511E-03 0,01584406 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,515E-03 0,01581998 ! elastic fiber assembly GO:0048251 17 10 1,000 1,515E-03 0,01575266 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 1,000 1,515E-03 0,01568592 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 1,515E-03 0,01561973 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 1,000 1,515E-03 0,0155541 ! B cell proliferation GO:0042100 19 10 1,000 1,515E-03 0,01548902 ! multicellular organism growth GO:0035264 19 10 1,000 1,515E-03 0,01542448 ! epithelial cell development GO:0002064 21 10 1,000 1,515E-03 0,01536048 ! motor axon guidance GO:0008045 22 10 1,000 1,515E-03 0,01529701 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,515E-03 0,01523406 ! regulation of fat cell differentiation GO:0045598 18 10 1,000 1,515E-03 0,01517162 ! response to nicotine GO:0035094 20 10 1,000 1,515E-03 0,0151097 ! response to nutrient GO:0007584 135 84 3,000 1,579E-03 0,01568508 ! carbohydrate homeostasis GO:0033500 59 39 2,000 1,588E-03 0,01570998 GO:0042593|glucose homeostasis, ! cellular response to hormone stimulus GO:0032870 182 85 3,000 1,65E-03 0,01625229 ! mammary gland development GO:0030879 93 40 2,000 1,71E-03 0,01677449 ! development of primary female sexual characteristics GO:0046545 80 40 2,000 1,71E-03 0,01670739 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 2,000 1,71E-03 0,01664083 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,845E-03 0,01788464 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,845E-03 0,01781395 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,845E-03 0,01774382 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,845E-03 0,01767423 ! regulation of intracellular pH GO:0051453 21 11 1,000 1,845E-03 0,01760519 ! behavioral fear response GO:0001662 27 11 1,000 1,845E-03 0,01753669 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 1,845E-03 0,01746872 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,845E-03 0,01740127 ! DNA methylation GO:0006306 19 11 1,000 1,845E-03 0,01733434 GO:0006305|DNA alkylation, ! thymus development GO:0048538 29 11 1,000 1,845E-03 0,01726793 ! regulation of DNA binding GO:0051101 167 89 3,000 1,953E-03 0,01821424 ! tube morphogenesis GO:0035239 194 89 3,000 1,953E-03 0,01814499 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,969E-03 0,01822496 ! T cell differentiation GO:0030217 93 42 2,000 1,969E-03 0,01815619 ! cytokinesis GO:0000910 84 42 2,000 1,969E-03 0,01808793 ! regulation of cell cycle process GO:0010564 161 90 3,000 2,035E-03 0,01861905 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 2,000 2,108E-03 0,01921602 ! striated muscle cell differentiation GO:0051146 91 43 2,000 2,108E-03 0,01914458 ! epithelial cell differentiation GO:0030855 83 43 2,000 2,108E-03 0,01907368 ! regulation of T cell proliferation GO:0042129 80 43 2,000 2,108E-03 0,0190033 ! regulation of myeloid cell differentiation GO:0045637 105 43 2,000 2,108E-03 0,01893343 ! ossification GO:0001503 205 91 3,000 2,119E-03 0,01896012 ! bone development GO:0060348 206 92 3,000 2,205E-03 0,01965946 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 2,205E-03 0,0195902 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 2,205E-03 0,01951922 ! histone acetylation GO:0016573 27 12 1,000 2,205E-03 0,01944875 ! mRNA polyadenylation GO:0006378 24 12 1,000 2,205E-03 0,01937879 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,205E-03 0,01930933 ! T cell homeostasis GO:0043029 28 12 1,000 2,205E-03 0,01924037 ! localization within membrane GO:0051668 26 12 1,000 2,205E-03 0,0191719 ! response to reactive oxygen species GO:0000302 75 44 2,000 2,252E-03 0,01951362 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 3,000 2,294E-03 0,01979895 GO:0010498|proteasomal protein catabolic process, ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 2,294E-03 0,01972924 ! B cell differentiation GO:0030183 124 45 2,000 2,403E-03 0,02059802 ! female gamete generation GO:0007292 71 45 2,000 2,403E-03 0,020526 ! developmental growth GO:0048589 88 45 2,000 2,403E-03 0,02045448 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 2,56E-03 0,02171142 ! pigmentation GO:0043473 103 46 2,000 2,56E-03 0,02163629 ! cell growth GO:0016049 90 46 2,000 2,56E-03 0,02156168 ! regulation of T cell activation GO:0050863 175 96 3,000 2,574E-03 0,02160875 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,596E-03 0,02171949 ! Golgi organization GO:0007030 25 13 1,000 2,596E-03 0,02164536 ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 2,596E-03 0,02157174 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,596E-03 0,02149861 ! gland morphogenesis GO:0022612 31 13 1,000 2,596E-03 0,02142598 ! spleen development GO:0048536 24 13 1,000 2,596E-03 0,02135384 ! digestive tract morphogenesis GO:0048546 31 13 1,000 2,596E-03 0,02128218 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of fatty acid oxidation GO:0046320 34 13 1,000 2,596E-03 0,021211 ! mRNA 3'-end processing GO:0031124 25 13 1,000 2,596E-03 0,0211403 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 2,596E-03 0,02107007 ! regulation of steroid biosynthetic process GO:0050810 20 13 1,000 2,596E-03 0,0210003 ! transcription initiation GO:0006352 171 97 3,000 2,672E-03 0,02154686 ! regulation of protein localization GO:0032880 188 97 3,000 2,672E-03 0,02147598 ! mitochondrial transport GO:0006839 94 48 2,000 2,891E-03 0,02315785 ! cellular component disassembly GO:0022411 89 48 2,000 2,891E-03 0,02308217 ! regulation of S phase GO:0033261 26 14 1,000 3,017E-03 0,02400778 ! hair follicle morphogenesis GO:0031069 27 14 1,000 3,017E-03 0,02392983 ! RNA polyadenylation GO:0043631 32 14 1,000 3,017E-03 0,02385239 ! palate development GO:0060021 32 14 1,000 3,017E-03 0,02377544 ! fear response GO:0042596 34 14 1,000 3,017E-03 0,023699 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 3,017E-03 0,02362304 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 37 14 1,000 3,017E-03 0,02354756 ! regulation of cellular pH GO:0030641 27 14 1,000 3,017E-03 0,02347257 ! positive regulation of protein polymerization GO:0032273 27 14 1,000 3,017E-03 0,02339806 ! negative regulation of immune system process GO:0002683 101 51 2,000 3,436E-03 0,02656559 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 3,468E-03 0,02672335 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 3,468E-03 0,02663931 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3,468E-03 0,0265558 ! regulation of cell-cell adhesion GO:0022407 35 15 1,000 3,468E-03 0,02647282 ! regulation of mRNA processing GO:0050684 26 15 1,000 3,468E-03 0,02639035 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 3,468E-03 0,02630839 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 3,468E-03 0,02622694 ! G1/S transition checkpoint GO:0031575 37 15 1,000 3,468E-03 0,02614599 ! intermediate filament cytoskeleton organization GO:0045104 34 15 1,000 3,468E-03 0,02606554 ! lymphocyte homeostasis GO:0002260 33 15 1,000 3,468E-03 0,02598559 ! response to estrogen stimulus GO:0043627 98 52 2,000 3,631E-03 0,02712627 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 3,832E-03 0,02854267 ! regulation of protein ubiquitination GO:0031396 28 16 1,000 3,948E-03 0,02931291 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 3,948E-03 0,02922408 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 3,948E-03 0,02913579 ! intermediate filament-based process GO:0045103 36 16 1,000 3,948E-03 0,02904803 ! axon cargo transport GO:0008088 46 16 1,000 3,948E-03 0,0289608 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 3,948E-03 0,02887409 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 3,948E-03 0,0287879 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,948E-03 0,02870222 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 4,255E-03 0,03084413 ! metencephalon development GO:0022037 32 17 1,000 4,457E-03 0,03221137 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 4,457E-03 0,03211636 ! signal complex assembly GO:0007172 47 17 1,000 4,457E-03 0,0320219 ! endothelial cell migration GO:0043542 31 17 1,000 4,457E-03 0,03192799 ! activation of MAPKK activity GO:0000186 43 17 1,000 4,457E-03 0,03183463 ! regulation of survival gene product expression GO:0045884 38 17 1,000 4,457E-03 0,03174182 ! cardiac muscle tissue development GO:0048738 34 17 1,000 4,457E-03 0,03164955 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 4,457E-03 0,03155781 GO:0031114|regulation of microtubule depolymerization, ! DNA unwinding during replication GO:0006268 26 17 1,000 4,457E-03 0,0314666 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 4,457E-03 0,03137592 ! RNA 3'-end processing GO:0031123 37 17 1,000 4,457E-03 0,03128576 ! regulation of protein catabolic process GO:0042176 126 56 2,000 4,476E-03 0,03133397 ! regulation of intracellular transport GO:0032386 108 57 2,000 4,705E-03 0,03283831 ! positive regulation of organelle organization GO:0010638 108 58 2,000 4,94E-03 0,03438226 ! positive regulation of protein complex assembly GO:0031334 34 18 1,000 4,994E-03 0,03466172 ! patterning of blood vessels GO:0001569 43 18 1,000 4,994E-03 0,03456353 ! regulation of viral genome replication GO:0045069 30 18 1,000 4,994E-03 0,03446589 ! epidermis morphogenesis GO:0048730 43 18 1,000 4,994E-03 0,03436881 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 4,994E-03 0,03427227 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 4,994E-03 0,03417626 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 1,000 4,994E-03 0,0340808 ! long-chain fatty acid transport GO:0015909 32 18 1,000 4,994E-03 0,03398587 ! defense response to virus GO:0051607 43 18 1,000 4,994E-03 0,03389146 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 4,994E-03 0,03379758 ! regulation of lipid biosynthetic process GO:0046890 28 19 1,000 5,56E-03 0,03752356 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 5,56E-03 0,03742019 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 5,56E-03 0,03731739 ! neuromuscular junction development GO:0007528 43 19 1,000 5,56E-03 0,03721515 ! regulation of steroid metabolic process GO:0019218 35 19 1,000 5,56E-03 0,03711347 ! cellular pigmentation GO:0033059 37 19 1,000 5,56E-03 0,03701234 ! regulation of homeostatic process GO:0032844 148 62 2,000 5,951E-03 0,03950852 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 6,154E-03 0,04074363 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 6,154E-03 0,04063351 ! protein amino acid acetylation GO:0006473 41 20 1,000 6,154E-03 0,04052398 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 6,154E-03 0,04041505 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 6,154E-03 0,0403067 GO:0010675|regulation of cellular carbohydrate metabolic process, ! bile acid metabolic process GO:0008206 34 20 1,000 6,154E-03 0,04019893 ! DNA duplex unwinding GO:0032508 30 20 1,000 6,154E-03 0,04009173 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 1,000 6,154E-03 0,0399851 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 6,154E-03 0,03987904 ! actin filament bundle formation GO:0051017 47 20 1,000 6,154E-03 0,03977354 ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 6,154E-03 0,0396686 ! negative regulation of translation GO:0017148 32 20 1,000 6,154E-03 0,03956421 ! skeletal system morphogenesis GO:0048705 118 63 2,000 6,222E-03 0,03989634 ! lipid phosphorylation GO:0046834 43 21 1,000 6,776E-03 0,04333164 ! ovarian follicle development GO:0001541 39 21 1,000 6,776E-03 0,0432185 ! smooth muscle contraction GO:0006939 48 21 1,000 6,776E-03 0,04310595 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 6,776E-03 0,04299399 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 6,776E-03 0,04288261 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 6,776E-03 0,0427718 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 6,776E-03 0,04266156 ! ear development GO:0043583 114 66 2,000 7,078E-03 0,04445057 ! gonad development GO:0008406 115 66 2,000 7,078E-03 0,04433659 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 7,424E-03 0,04638761 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 1,000 7,424E-03 0,04626927 ! microtubule-based transport GO:0010970 59 22 1,000 7,424E-03 0,04615154 ! cellular response to starvation GO:0009267 37 22 1,000 7,424E-03 0,0460344 ! central nervous system neuron development GO:0021954 47 22 1,000 7,424E-03 0,04591786 ! ureteric bud development GO:0001657 50 22 1,000 7,424E-03 0,04580191 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 7,424E-03 0,04568654 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 7,424E-03 0,04557175 ! renal system process GO:0003014 42 22 1,000 7,424E-03 0,04545753 ! cholesterol biosynthetic process GO:0006695 39 22 1,000 7,424E-03 0,04534389 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 7,424E-03 0,04523081 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 7,424E-03 0,0451183 ! peptidyl-serine modification GO:0018209 50 22 1,000 7,424E-03 0,04500634 ! positive regulation of B cell activation GO:0050871 42 22 1,000 7,424E-03 0,04489494 ! response to cytokine stimulus GO:0034097 69 22 1,000 7,424E-03 0,04478409 ! activation of JUN kinase activity GO:0007257 47 22 1,000 7,424E-03 0,04467378 ! gut development GO:0048565 44 22 1,000 7,424E-03 0,04456402 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 7,424E-03 0,04445479 ! extracellular matrix organization GO:0030198 146 68 2,000 7,685E-03 0,04590492 ! negative regulation of ligase activity GO:0051352 116 68 2,000 7,685E-03 0,04579296 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! lung development GO:0030324 165 69 2,000 8E-03 0,04755316 ! urogenital system development GO:0001655 149 69 2,000 8E-03 0,04743774 ! homeostasis of number of cells GO:0048872 131 69 2,000 8E-03 0,04732288 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 1,000 8,1E-03 0,04779751 ! regeneration GO:0031099 42 23 1,000 8,1E-03 0,04768234 ! response to ethanol GO:0045471 47 23 1,000 8,1E-03 0,04756772 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 8,1E-03 0,04745365 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 8,1E-03 0,04734012 ! DNA modification GO:0006304 36 23 1,000 8,1E-03 0,04722714 ! fatty acid transport GO:0015908 47 23 1,000 8,1E-03 0,04711469 ! germ cell development GO:0007281 133 70 2,000 8,323E-03 0,04829435 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 8,802E-03 0,05095666 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 8,802E-03 0,05083619 ! central nervous system neuron differentiation GO:0021953 51 24 1,000 8,802E-03 0,0507163 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 8,802E-03 0,05059696 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 8,802E-03 0,05047819 ! regulation of viral reproduction GO:0050792 41 24 1,000 8,802E-03 0,05035998 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 8,802E-03 0,05024231 ! negative regulation of catabolic process GO:0009895 52 24 1,000 8,802E-03 0,0501252 ! respiratory tube development GO:0030323 171 72 2,000 8,99E-03 0,05107549 ! B cell activation GO:0042113 179 72 2,000 8,99E-03 0,05095698 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 9,531E-03 0,05389665 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 9,531E-03 0,05377218 ! vasculogenesis GO:0001570 49 25 1,000 9,531E-03 0,05364828 ! regulation of insulin secretion GO:0050796 42 25 1,000 9,531E-03 0,05352495 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 9,531E-03 0,05340219 ! lymphocyte proliferation GO:0046651 55 25 1,000 9,531E-03 0,05327999 ! leukocyte homeostasis GO:0001776 50 25 1,000 9,531E-03 0,05315834 ! protein tetramerization GO:0051262 57 25 1,000 9,531E-03 0,05303725 ! respiratory system development GO:0060541 175 74 2,000 9,688E-03 0,05378961 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,01004831 0,05566447 ! myelination GO:0042552 50 26 1,000 0,01028502 0,05684682 ! molting cycle process GO:0022404 52 26 1,000 0,01028502 0,0567185 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 0,01028502 0,05659076 ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,01028502 0,05646359 ! osteoblast differentiation GO:0001649 63 26 1,000 0,01028502 0,05633699 ! negative regulation of cell development GO:0010721 83 26 1,000 0,01028502 0,05621095 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,01028502 0,05608548 GO:0045840|positive regulation of mitosis, ! blastocyst development GO:0001824 50 26 1,000 0,01028502 0,05596057 ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 0,01028502 0,05583621 ! lymphocyte differentiation GO:0030098 193 76 2,000 0,01041649 0,05642456 ! regulation of catabolic process GO:0009894 173 77 2,000 0,0107924 0,05833151 ! response to starvation GO:0042594 47 27 1,000 0,01106497 0,05967269 ! response to toxin GO:0009636 49 27 1,000 0,01106497 0,05954126 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01106497 0,0594104 ! cellular response to nutrient levels GO:0031669 45 27 1,000 0,01106497 0,05928011 ! leukocyte proliferation GO:0070661 59 27 1,000 0,01106497 0,05915039 GO:0032943|mononuclear cell proliferation, ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 0,01117609 0,05961396 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 0,01156758 0,06156775 ! protein oligomerization GO:0051259 149 79 2,000 0,01156758 0,06143391 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 0,01187019 0,06290426 ! spliceosomal snRNP biogenesis GO:0000387 40 28 1,000 0,01187019 0,0627681 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01187019 0,06263253 ! dendrite development GO:0016358 67 28 1,000 0,01187019 0,06249755 ! negative regulation of protein modification process GO:0031400 66 28 1,000 0,01187019 0,06236314 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 0,01187019 0,06222932 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 0,01187019 0,06209606 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 2,000 0,01196689 0,0624682 ! activation of protein kinase activity GO:0032147 170 80 2,000 0,01196689 0,062335 ! development of primary sexual characteristics GO:0045137 143 80 2,000 0,01196689 0,06220238 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01196689 0,06207031 ! muscle cell differentiation GO:0042692 178 81 2,000 0,01237405 0,0640462 ! response to hypoxia GO:0001666 178 81 2,000 0,01237405 0,0639108 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 0,01237405 0,06377597 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 2,000 0,01237405 0,0636417 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 0,01270033 0,06518257 ! regulation of peptide secretion GO:0002791 52 29 1,000 0,01270033 0,06504592 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01270033 0,06490984 ! somitogenesis GO:0001756 52 29 1,000 0,01270033 0,06477433 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01270033 0,06463938 ! response to oxygen levels GO:0070482 183 83 2,000 0,01321201 0,06710381 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 0,01321201 0,06696459 GO:0045937|positive regulation of phosphate metabolic process, ! myofibril assembly GO:0030239 50 30 1,000 0,01355509 0,06856123 GO:0055002|striated muscle cell development, ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01355509 0,06841957 ! sterol biosynthetic process GO:0016126 56 30 1,000 0,01355509 0,0682785 ! response to metal ion GO:0010038 158 84 2,000 0,01364284 0,06857915 ! T cell activation GO:0042110 189 84 2,000 0,01364284 0,06843833 ! negative regulation of transport GO:0051051 164 85 2,000 0,01408161 0,07049462 ! cholesterol metabolic process GO:0008203 148 85 2,000 0,01408161 0,07035046 ! ovulation cycle process GO:0022602 55 31 1,000 0,01443414 0,07196448 ! male gonad development GO:0008584 56 31 1,000 0,01443414 0,07181792 ! iron ion homeostasis GO:0055072 60 31 1,000 0,01443414 0,07167195 ! erythrocyte differentiation GO:0030218 62 31 1,000 0,01443414 0,07152657 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01443414 0,07138178 GO:0008366|axon ensheathment, ! response to heat GO:0009408 54 31 1,000 0,01443414 0,07123757 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,01452833 0,07155788 GO:0002696|positive regulation of leukocyte activation, ! regulation of protein transport GO:0051223 165 87 2,000 0,01498301 0,07364889 GO:0070201|regulation of establishment of protein localization, ! spindle organization GO:0007051 50 32 1,000 0,01533717 0,07523837 ! metanephros development GO:0001656 81 32 1,000 0,01533717 0,07508759 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,01533717 0,07493742 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,01533717 0,07478784 ! muscle cell development GO:0055001 52 32 1,000 0,01533717 0,07463886 ! ovulation cycle GO:0042698 57 32 1,000 0,01533717 0,07449047 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01533717 0,07434268 ! hindbrain development GO:0030902 65 32 1,000 0,01533717 0,07419546 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,01533717 0,07404883 ! myeloid leukocyte activation GO:0002274 53 32 1,000 0,01533717 0,07390278 ! positive regulation of catabolic process GO:0009896 72 32 1,000 0,01533717 0,0737573 ! regulation of pH GO:0006885 56 33 1,000 0,01626387 0,07806021 ! negative regulation of response to external stimulus GO:0032102 50 33 1,000 0,01626387 0,07790715 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,01626387 0,07775469 ! response to inorganic substance GO:0010035 173 90 2,000 0,01639501 0,07822853 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01721394 0,08197594 ! post-embryonic development GO:0009791 76 34 1,000 0,01721394 0,08181645 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01818706 0,08627377 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01818706 0,08610657 ! placenta development GO:0001890 53 35 1,000 0,01818706 0,08594002 ! sterol metabolic process GO:0016125 166 94 2,000 0,01839 0,0867312 ! regulation of membrane potential GO:0042391 179 94 2,000 0,01839 0,08656409 ! regulation of muscle development GO:0048634 82 36 1,000 0,01918294 0,09012291 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01918294 0,08994993 ! positive regulation of cell development GO:0010720 85 36 1,000 0,01918294 0,08977762 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,01918294 0,08960596 ! embryonic organ development GO:0048568 67 36 1,000 0,01918294 0,08943495 ! sex differentiation GO:0007548 171 96 2,000 0,0194358 0,09044126 ! response to protein stimulus GO:0051789 158 96 2,000 0,0194358 0,09026931 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,02020127 0,09364647 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,02020127 0,09346911 ! sister chromatid segregation GO:0000819 65 37 1,000 0,02020127 0,09329242 ! odontogenesis GO:0042476 74 37 1,000 0,02020127 0,0931164 ! actomyosin structure organization GO:0031032 68 37 1,000 0,02020127 0,09294104 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,02020127 0,09276634 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,02124175 0,09736134 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 0,02124175 0,09717902 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 0,02124175 0,09699737 ! pigment metabolic process GO:0042440 87 38 1,000 0,02124175 0,09681641 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,02162426 0,09837628 GO:0060538|skeletal muscle organ development, ! hormone metabolic process GO:0042445 171 100 2,000 0,02162426 0,09819343 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,0223041 0,10109259 ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,0223041 0,10090538 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,0223041 0,10071886 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! lipid homeostasis GO:0055088 75 40 1,000 0,02338801 0,10541865 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,02338801 0,10522451 ! regulation of hormone secretion GO:0046883 69 41 1,000 0,0244932 0,1099943 ! feeding behavior GO:0007631 69 41 1,000 0,0244932 0,10979247 ! mesenchymal cell development GO:0014031 94 41 1,000 0,0244932 0,10959139 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,0244932 0,10939104 ! maintenance of protein location GO:0045185 95 41 1,000 0,0244932 0,10919142 ! ear morphogenesis GO:0042471 64 42 1,000 0,02561939 0,11400396 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,02676629 0,11889098 GO:0090047|positive regulation of transcription regulator activity, ! glucose transport GO:0015758 66 43 1,000 0,02676629 0,11867521 ! monocarboxylic acid transport GO:0015718 93 43 1,000 0,02676629 0,11846022 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 1,000 0,02676629 0,118246 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,02676629 0,11803256 ! segmentation GO:0035282 78 43 1,000 0,02676629 0,11781989 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,02793361 0,12273707 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,02793361 0,12251672 ! hexose transport GO:0008645 68 44 1,000 0,02793361 0,12229715 GO:0015749|monosaccharide transport, ! striated muscle contraction GO:0006941 85 44 1,000 0,02793361 0,12207837 ! biopolymer methylation GO:0043414 91 45 1,000 0,02912108 0,12704072 ! maintenance of location in cell GO:0051651 101 45 1,000 0,02912108 0,12681427 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02919547 0,12691196 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02919547 0,12668654 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02919547 0,12646192 ! neuron fate determination GO:0048664 7 5 0,000 0,02919547 0,12623809 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02919547 0,12601506 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02919547 0,12579281 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02919547 0,12557134 ! polyol transport GO:0015791 12 5 0,000 0,02919547 0,12535065 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02919547 0,12513074 ! response to superoxide GO:0000303 10 5 0,000 0,02919547 0,1249116 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02919547 0,12469322 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02919547 0,12447561 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02919547 0,12425875 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02919547 0,12404265 ! female meiosis GO:0007143 10 5 0,000 0,02919547 0,1238273 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02919547 0,12361269 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02919547 0,12339883 ! hypothalamus development GO:0021854 9 5 0,000 0,02919547 0,1231857 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02919547 0,12297331 ! cobalt ion transport GO:0006824 11 5 0,000 0,02919547 0,12276166 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02919547 0,12255073 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02919547 0,12234052 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02919547 0,12213103 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02919547 0,12192226 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02919547 0,1217142 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02919547 0,12150685 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02919547 0,12130021 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02919547 0,12109427 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02919547 0,12088902 ! transposition GO:0032196 9 5 0,000 0,02919547 0,12068447 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02919547 0,12048061 ! negative chemotaxis GO:0050919 16 5 0,000 0,02919547 0,12027744 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02919547 0,12007495 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02919547 0,11987315 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02919547 0,11967202 ! behavioral response to pain GO:0048266 10 5 0,000 0,02919547 0,11947156 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02919547 0,11927178 ! Notch receptor processing GO:0007220 11 5 0,000 0,02919547 0,11907266 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02919547 0,1188742 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02919547 0,11867641 ! micturition GO:0060073 9 5 0,000 0,02919547 0,11847927 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02919547 0,11828279 ! copulation GO:0007620 9 5 0,000 0,02919547 0,11808696 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02919547 0,11789177 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02919547 0,11769723 ! bioluminescence GO:0008218 9 5 0,000 0,02919547 0,11750333 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02919547 0,11731007 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02919547 0,11711744 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02919547 0,11692545 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02919547 0,11673408 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02919547 0,11654334 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02919547 0,11635322 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02919547 0,11616372 ! grooming behavior GO:0007625 6 5 0,000 0,02919547 0,11597483 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02919547 0,11578656 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02919547 0,1155989 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02919547 0,11541185 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02919547 0,1152254 ! response to protozoan GO:0001562 13 5 0,000 0,02919547 0,11503955 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,02919547 0,1148543 ! lymph vessel development GO:0001945 10 5 0,000 0,02919547 0,11466965 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02919547 0,11448559 ! endochondral ossification GO:0001958 17 5 0,000 0,02919547 0,11430212 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02919547 0,11411924 ! single strand break repair GO:0000012 8 5 0,000 0,02919547 0,11393694 ! parathyroid gland development GO:0060017 14 5 0,000 0,02919547 0,11375522 ! anagen GO:0042640 7 5 0,000 0,02919547 0,11357408 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02919547 0,11339352 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02919547 0,11321353 ! cytokine secretion GO:0050663 15 5 0,000 0,02919547 0,11303411 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02919547 0,11285526 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02919547 0,11267697 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02919547 0,11249925 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02919547 0,11232208 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02919547 0,11214548 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02919547 0,11196942 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02919547 0,11179392 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02919547 0,11161897 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02919547 0,11144457 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02919547 0,11127071 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02919547 0,11109739 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02919547 0,11092461 ! valine metabolic process GO:0006573 12 5 0,000 0,02919547 0,11075236 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02919547 0,11058066 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02919547 0,11040948 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02919547 0,11023883 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02919547 0,11006871 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02919547 0,10989911 ! polyol catabolic process GO:0046174 9 5 0,000 0,02919547 0,10973003 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02919547 0,10956148 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02919547 0,10939344 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02919547 0,10922592 ! muscle cell migration GO:0014812 8 5 0,000 0,02919547 0,1090589 ! mitochondrial fission GO:0000266 8 5 0,000 0,02919547 0,1088924 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02919547 0,10872641 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02919547 0,10856092 ! mRNA transcription GO:0009299 10 5 0,000 0,02919547 0,10839593 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02919547 0,10823145 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02919547 0,10806746 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02919547 0,10790397 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02919547 0,10774097 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02919547 0,10757847 ! monocyte activation GO:0042117 10 5 0,000 0,02919547 0,10741645 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02919547 0,10725492 GO:0060177|regulation of angiotensin metabolic process, ! response to food GO:0032094 6 5 0,000 0,02919547 0,10709388 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02919547 0,10693332 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02919547 0,10677324 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02919547 0,10661364 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02919547 0,10645451 ! forebrain neuron development GO:0021884 13 5 0,000 0,02919547 0,10629586 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02919547 0,10613768 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02919547 0,10597997 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02919547 0,10582273 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02919547 0,10566596 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02919547 0,10550965 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02919547 0,1053538 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02919547 0,10519841 ! lipid glycosylation GO:0030259 7 5 0,000 0,02919547 0,10504348 ! nucleobase transport GO:0015851 6 5 0,000 0,02919547 0,104889 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02919547 0,10473498 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02919547 0,10458141 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02919547 0,10442829 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02919547 0,10427562 ! basic amino acid transport GO:0015802 12 5 0,000 0,02919547 0,10412339 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02919547 0,10397161 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02919547 0,10382027 ! actin nucleation GO:0045010 11 5 0,000 0,02919547 0,10366936 ! depurination GO:0045007 5 5 0,000 0,02919547 0,1035189 ! depyrimidination GO:0045008 10 5 0,000 0,02919547 0,10336887 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02919547 0,10321928 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02919547 0,10307012 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02919547 0,10292139 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02919547 0,10277309 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02919547 0,10262521 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02919547 0,10247776 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02919547 0,10233074 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02919547 0,10218413 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02919547 0,10203794 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02919547 0,10189218 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02919547 0,10174682 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02919547 0,10160188 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02919547 0,10145736 ! response to arsenic GO:0046685 11 5 0,000 0,02919547 0,10131324 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02919547 0,10116954 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02919547 0,10102624 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02919547 0,10088334 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02919547 0,10074085 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02919547 0,10059876 ! response to mercury ion GO:0046689 8 5 0,000 0,02919547 0,10045707 ! response to cadmium ion GO:0046686 7 5 0,000 0,02919547 0,10031578 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02919547 0,10017489 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02919547 0,10003439 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02919547 0,09989429 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02919547 0,09975458 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02919547 0,09961526 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02919547 0,09947632 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02919547 0,09933778 ! decidualization GO:0046697 11 5 0,000 0,02919547 0,09919961 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02919547 0,09906184 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02919547 0,09892444 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02919547 0,09878743 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02919547 0,09865079 ! embryonic cleavage GO:0040016 6 5 0,000 0,02919547 0,09851453 ! peroxisome fission GO:0016559 5 5 0,000 0,02919547 0,09837865 ! histone demethylation GO:0016577 13 5 0,000 0,02919547 0,09824314 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02919547 0,09810801 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02919547 0,09797325 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02919547 0,09783885 ! metaphase plate congression GO:0051310 7 5 0,000 0,02919547 0,09770483 ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02919547 0,09757117 ! enteric nervous system development GO:0048484 8 5 0,000 0,02919547 0,09743787 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02919547 0,09730494 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02919547 0,09717237 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02919547 0,09704017 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02919547 0,09690832 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02919547 0,09677683 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02919547 0,09664569 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02919547 0,09651492 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02919547 0,09638449 ! metaphase GO:0051323 11 5 0,000 0,02919547 0,09625442 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02919547 0,09612469 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02919547 0,09599532 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02919547 0,09586629 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02919547 0,09573761 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02919547 0,09560928 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02919547 0,09548129 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02919547 0,09535364 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02919547 0,09522633 ! response to redox state GO:0051775 6 5 0,000 0,02919547 0,09509936 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02919547 0,09497273 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02919547 0,09484644 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02919547 0,09472048 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02919547 0,09459486 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02919547 0,09446957 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02919547 0,09434461 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02919547 0,09421998 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02919547 0,09409568 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02919547 0,0939717 ! striatum development GO:0021756 14 5 0,000 0,02919547 0,09384806 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02919547 0,09372473 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02919547 0,09360174 ! glial cell migration GO:0008347 10 5 0,000 0,02919547 0,09347906 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02919547 0,09335671 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02919547 0,09323467 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02919547 0,09311295 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02919547 0,09299156 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02919547 0,09287047 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02919547 0,0927497 ! neuroprotection GO:0043526 8 5 0,000 0,02919547 0,09262925 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02919547 0,09250911 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02919547 0,09238928 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02919547 0,09226976 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02919547 0,09215055 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02919547 0,09203164 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02919547 0,09191304 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02919547 0,09179475 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02919547 0,09167676 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02919547 0,09155908 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02919547 0,0914417 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02919547 0,09132461 ! spindle assembly GO:0051225 6 5 0,000 0,02919547 0,09120783 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02919547 0,09109134 GO:0022011|myelination in the peripheral nervous system, ! protein palmitoylation GO:0018345 12 5 0,000 0,02919547 0,09097516 ! drug metabolic process GO:0017144 7 5 0,000 0,02919547 0,09085926 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02919547 0,09074367 ! organ regeneration GO:0031100 7 5 0,000 0,02919547 0,09062836 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02919547 0,09051335 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02919547 0,09039863 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 0,03032843 0,09378778 ! glycolysis GO:0006096 71 46 1,000 0,03032843 0,09366921 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,03032843 0,09355094 ! positive regulation of protein transport GO:0051222 80 46 1,000 0,03032843 0,09343297 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,03155537 0,09709039 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,03280164 0,10079799 ! endosome transport GO:0016197 127 48 1,000 0,03280164 0,10067136 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,03280164 0,10054505 ! male sex differentiation GO:0046661 93 48 1,000 0,03280164 0,10041905 ! methylation GO:0032259 97 48 1,000 0,03280164 0,10029337 ! response to calcium ion GO:0051592 94 49 1,000 0,03406697 0,104032 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,03406697 0,10390212 ! JNK cascade GO:0007254 106 49 1,000 0,03406697 0,10377257 ! protein homooligomerization GO:0051260 84 49 1,000 0,03406697 0,10364333 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03493195 0,10614273 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03493195 0,10601088 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03493195 0,10587935 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03493195 0,10574815 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03493195 0,10561727 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03493195 0,10548672 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03493195 0,10535649 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03493195 0,10522658 ! response to oxygen radical GO:0000305 11 6 0,000 0,03493195 0,10509699 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03493195 0,10496772 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03493195 0,10483877 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03493195 0,10471013 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03493195 0,10458181 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03493195 0,1044538 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03493195 0,10432611 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03493195 0,10419873 ! forebrain regionalization GO:0021871 9 6 0,000 0,03493195 0,10407165 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03493195 0,10394489 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03493195 0,10381844 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03493195 0,10369229 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03493195 0,10356645 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,03493195 0,10344092 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03493195 0,10331569 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03493195 0,10319076 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03493195 0,10306613 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03493195 0,10294181 ! malate metabolic process GO:0006108 13 6 0,000 0,03493195 0,10281778 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03493195 0,10269405 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03493195 0,10257062 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03493195 0,10244749 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03493195 0,10232465 ! protein refolding GO:0042026 15 6 0,000 0,03493195 0,1022021 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03493195 0,10207985 ! opsonization GO:0008228 8 6 0,000 0,03493195 0,10195789 ! mating behavior GO:0007617 7 6 0,000 0,03493195 0,10183622 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03493195 0,10171485 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03493195 0,10159376 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03493195 0,10147296 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,03493195 0,10135244 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03493195 0,10123221 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03493195 0,10111227 ! toxin metabolic process GO:0009404 11 6 0,000 0,03493195 0,10099261 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03493195 0,10087323 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03493195 0,10075414 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03493195 0,10063533 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03493195 0,10051679 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03493195 0,10039854 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03493195 0,10028056 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03493195 0,10016286 ! thymic T cell selection GO:0045061 16 6 0,000 0,03493195 0,10004544 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03493195 0,09992829 ! protein lipoylation GO:0009249 10 6 0,000 0,03493195 0,09981141 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03493195 0,09969481 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03493195 0,09957848 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03493195 0,09946242 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03493195 0,09934663 ! glutamate catabolic process GO:0006538 12 6 0,000 0,03493195 0,09923111 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03493195 0,09911586 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03493195 0,09900088 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03493195 0,09888616 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03493195 0,09877171 ! hyperosmotic response GO:0006972 10 6 0,000 0,03493195 0,09865752 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03493195 0,0985436 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03493195 0,09842994 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03493195 0,09831654 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03493195 0,0982034 ! urea metabolic process GO:0019627 7 6 0,000 0,03493195 0,09809052 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03493195 0,09797791 ! neutrophil activation GO:0042119 7 6 0,000 0,03493195 0,09786555 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03493195 0,09775344 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03493195 0,0976416 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03493195 0,09753001 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03493195 0,09741867 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03493195 0,09730759 ! neuron apoptosis GO:0051402 15 6 0,000 0,03493195 0,09719676 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03493195 0,09708618 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03493195 0,09697586 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03493195 0,09686578 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03493195 0,09675596 ! carnitine transport GO:0015879 10 6 0,000 0,03493195 0,09664638 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03493195 0,09653705 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03493195 0,09642797 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03493195 0,09631914 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03493195 0,09621055 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03493195 0,0961022 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03493195 0,0959941 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03493195 0,09588624 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03493195 0,09577863 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,03493195 0,09567125 GO:0045686|negative regulation of glial cell differentiation, ! astrocyte development GO:0014002 16 6 0,000 0,03493195 0,09556412 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03493195 0,09545722 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03493195 0,09535057 ! interaction with symbiont GO:0051702 14 6 0,000 0,03493195 0,09524415 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03493195 0,09513797 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03493195 0,09503202 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03493195 0,09492631 ! response to copper ion GO:0046688 10 6 0,000 0,03493195 0,09482084 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03493195 0,0947156 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03493195 0,09461059 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03493195 0,09450582 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03493195 0,09440128 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03493195 0,09429697 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03493195 0,09419289 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03493195 0,09408904 ! hair follicle maturation GO:0048820 8 6 0,000 0,03493195 0,09398541 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03493195 0,09388202 ! Schwann cell development GO:0014044 15 6 0,000 0,03493195 0,09377885 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03493195 0,09367591 ! response to pheromone GO:0019236 6 6 0,000 0,03493195 0,0935732 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03493195 0,09347071 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03493195 0,09336844 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03493195 0,0932664 ! subpallium development GO:0021544 15 6 0,000 0,03493195 0,09316458 ! neural tube patterning GO:0021532 8 6 0,000 0,03493195 0,09306298 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03493195 0,09296161 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03493195 0,09286045 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03493195 0,09275952 ! G2 phase GO:0051319 16 6 0,000 0,03493195 0,0926588 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03493195 0,0925583 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03493195 0,09245802 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03493195 0,09235796 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03493195 0,09225811 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03493195 0,09215848 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03493195 0,09205907 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03493195 0,09195987 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03493195 0,09186088 ! receptor internalization GO:0031623 11 6 0,000 0,03493195 0,0917621 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03493195 0,09166354 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03493195 0,09156519 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03493195 0,09146705 ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03493195 0,09136912 ! protein deubiquitination GO:0016579 16 6 0,000 0,03493195 0,0912714 ! protein destabilization GO:0031648 9 6 0,000 0,03493195 0,09117388 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03493195 0,09107658 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03493195 0,09097948 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03493195 0,09088259 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03493195 0,09078591 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03493195 0,09068943 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03493195 0,09059316 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03493195 0,09049709 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03493195 0,09040122 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03493195 0,09030556 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03493195 0,0902101 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03493195 0,09011484 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03493195 0,09001979 ! neural plate development GO:0001840 9 6 0,000 0,03493195 0,08992493 ! catecholamine transport GO:0051937 9 6 0,000 0,03493195 0,08983027 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03493195 0,08973581 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03493195 0,08964155 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03493195 0,08954749 ! maternal placenta development GO:0001893 12 6 0,000 0,03493195 0,08945362 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03493195 0,08935995 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03493195 0,08926648 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03493195 0,0891732 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03493195 0,08908012 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03493195 0,08898723 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03493195 0,08889454 GO:0055081|anion homeostasis, ! regulation of action potential GO:0001508 102 50 1,000 0,03535108 0,08986753 ! regulation of ossification GO:0030278 123 50 1,000 0,03535108 0,08977412 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,03535108 0,08968089 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,03665373 0,09288907 ! response to temperature stimulus GO:0009266 84 51 1,000 0,03665373 0,09279281 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,03665373 0,09269676 ! positive regulation of binding GO:0051099 88 52 1,000 0,03797464 0,09593801 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,03797464 0,0958389 ! histone modification GO:0016570 104 52 1,000 0,03797464 0,09574 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,03797464 0,0956413 ! positive regulation of growth GO:0045927 96 53 1,000 0,03931357 0,09891147 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 1,000 0,03931357 0,09880971 ! vesicle organization GO:0016050 127 53 1,000 0,03931357 0,09870816 ! synapse organization GO:0050808 102 53 1,000 0,03931357 0,09860682 ! tRNA transcription GO:0009304 17 7 0,000 0,0406347 0,10181597 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,0406347 0,10171165 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,0406347 0,10160755 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,0406347 0,10150365 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,0406347 0,10139997 ! sleep GO:0030431 16 7 0,000 0,0406347 0,1012965 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,0406347 0,10119324 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,0406347 0,1010902 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,0406347 0,10098736 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,0406347 0,10088473 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0406347 0,10078231 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,0406347 0,10068009 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,0406347 0,10057809 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0406347 0,10047629 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,0406347 0,10037469 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,0406347 0,1002733 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,0406347 0,10017212 ! glycolipid transport GO:0046836 11 7 0,000 0,0406347 0,10007114 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,0406347 0,09997036 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,0406347 0,09986979 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,0406347 0,09976942 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,0406347 0,09966925 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,0406347 0,09956928 ! mRNA stabilization GO:0048255 18 7 0,000 0,0406347 0,09946951 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,0406347 0,09936994 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,0406347 0,09927057 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,0406347 0,0991714 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,0406347 0,09907243 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,0406347 0,09897365 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,0406347 0,09887507 ! rhythmic behavior GO:0007622 17 7 0,000 0,0406347 0,09877669 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,0406347 0,0986785 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,0406347 0,09858051 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,0406347 0,09848271 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,0406347 0,09838511 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,0406347 0,09828769 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,0406347 0,09819048 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,0406347 0,09809345 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,0406347 0,09799662 ! mechanosensory behavior GO:0007638 16 7 0,000 0,0406347 0,09789997 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,0406347 0,09780352 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,0406347 0,09770726 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,0406347 0,09761118 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,0406347 0,0975153 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0406347 0,0974196 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0406347 0,09732409 ! spinal cord patterning GO:0021511 14 7 0,000 0,0406347 0,09722877 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,0406347 0,09713363 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,0406347 0,09703868 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,0406347 0,09694392 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,0406347 0,09684934 ! adrenal gland development GO:0030325 17 7 0,000 0,0406347 0,09675494 ! cysteine metabolic process GO:0006534 13 7 0,000 0,0406347 0,09666073 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,0406347 0,0965667 ! ovulation GO:0030728 10 7 0,000 0,0406347 0,09647286 ! adenohypophysis development GO:0021984 11 7 0,000 0,0406347 0,0963792 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,0406347 0,09628571 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,0406347 0,09619241 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,0406347 0,0960993 ! microtubule nucleation GO:0007020 21 7 0,000 0,0406347 0,09600636 ! proline biosynthetic process GO:0006561 10 7 0,000 0,0406347 0,0959136 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,0406347 0,09582102 ! thyroid hormone generation GO:0006590 13 7 0,000 0,0406347 0,09572861 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,0406347 0,09563639 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,0406347 0,09554434 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0406347 0,09545247 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,0406347 0,09536078 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,0406347 0,09526926 ! galactose metabolic process GO:0006012 13 7 0,000 0,0406347 0,09517792 ! vesicle fusion GO:0006906 20 7 0,000 0,0406347 0,09508675 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,0406347 0,09499576 ! intracellular pH reduction GO:0051452 13 7 0,000 0,0406347 0,09490494 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,0406347 0,0948143 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,0406347 0,09472383 ! nucleoside transport GO:0015858 11 7 0,000 0,0406347 0,09463353 ! nucleoside salvage GO:0043174 11 7 0,000 0,0406347 0,0945434 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,0406347 0,09445345 ! male sex determination GO:0030238 15 7 0,000 0,0406347 0,09436366 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,0406347 0,09427405 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,0406347 0,0941846 ! parturition GO:0007567 16 7 0,000 0,0406347 0,09409533 ! rRNA modification GO:0000154 14 7 0,000 0,0406347 0,09400622 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,0406347 0,09391729 ! spindle checkpoint GO:0031577 16 7 0,000 0,0406347 0,09382852 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,0406347 0,09373992 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,0406347 0,09365148 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,0406347 0,09356322 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,0406347 0,09347511 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,0406347 0,09338718 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,0406347 0,09329941 ! fibrinolysis GO:0042730 11 7 0,000 0,0406347 0,0932118 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,0406347 0,09312436 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,0406347 0,09303709 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,0406347 0,09294997 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,0406347 0,09286302 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,0406347 0,09277624 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,0406347 0,09268961 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,0406347 0,09260315 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,0406347 0,09251684 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,0406347 0,0924307 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,0406347 0,09234472 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,0406347 0,0922589 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,0406347 0,09217323 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,0406347 0,09208773 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,0406347 0,09200238 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,0406347 0,0919172 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,0406347 0,09183217 ! histone ubiquitination GO:0016574 9 7 0,000 0,0406347 0,09174729 ! regulation of meiosis GO:0040020 12 7 0,000 0,0406347 0,09166258 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,0406347 0,09157802 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,0406347 0,09149361 GO:0002714|positive regulation of B cell mediated immunity, ! membrane to membrane docking GO:0022614 14 7 0,000 0,0406347 0,09140937 ! transcription termination GO:0006353 14 7 0,000 0,0406347 0,09132527 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,0406347 0,09124133 ! anaphase GO:0051322 18 7 0,000 0,0406347 0,09115755 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,0406347 0,09107392 ! axonal fasciculation GO:0007413 19 7 0,000 0,0406347 0,09099044 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,0406347 0,09090712 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,0406347 0,09082395 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,0406347 0,09074092 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,0406347 0,09065806 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,0406347 0,09057534 ! thiamin metabolic process GO:0006772 7 7 0,000 0,0406347 0,09049277 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0406347 0,09041036 ! antibiotic transport GO:0042891 9 7 0,000 0,0406347 0,09032809 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,0406347 0,09024597 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,0406347 0,09016401 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,0406347 0,09008219 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,0406347 0,09000052 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,0406347 0,089919 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,0406347 0,08983762 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,0406347 0,08975639 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,0406347 0,08967531 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,0406347 0,08959438 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,0406347 0,08951359 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,0406347 0,08943295 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,0406347 0,08935245 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,0406347 0,0892721 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,0406347 0,08919189 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,0406347 0,08911182 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,0406347 0,0890319 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,0406347 0,08895213 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,0406347 0,08887249 ! muscle adaptation GO:0043500 13 7 0,000 0,0406347 0,088793 ! embryonic heart tube development GO:0035050 14 7 0,000 0,0406347 0,08871365 ! retina homeostasis GO:0001895 12 7 0,000 0,0406347 0,08863444 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,0406347 0,08855537 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,0406347 0,08847645 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,0406347 0,08839766 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,0406347 0,08831901 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,04067024 0,08831768 ! regulation of translational initiation GO:0006446 87 54 1,000 0,04067024 0,08823924 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,04067024 0,08816095 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 1,000 0,04067024 0,08808279 ! covalent chromatin modification GO:0016569 115 54 1,000 0,04067024 0,08800477 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,04067024 0,08792689 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,0420444 0,0908174 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,0420444 0,09073717 ! regulation of protein polymerization GO:0032271 117 55 1,000 0,0420444 0,09065709 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,04343582 0,09357469 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,04343582 0,09349225 ! glucose catabolic process GO:0006007 88 56 1,000 0,04343582 0,09340995 ! RNA elongation GO:0006354 90 56 1,000 0,04343582 0,09332779 ! chloride transport GO:0006821 102 57 1,000 0,04484422 0,09626928 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,04484422 0,09618476 ! muscle fiber development GO:0048747 131 57 1,000 0,04484422 0,09610038 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,04484422 0,09601616 ! regulation of actin filament length GO:0030832 118 58 1,000 0,04626938 0,09898081 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,04626938 0,09889422 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,04626938 0,09880777 ! maintenance of location GO:0051235 124 58 1,000 0,04626938 0,09872147 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04630391 0,09870895 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04630391 0,09862289 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04630391 0,09853698 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04630391 0,09845122 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04630391 0,09836561 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04630391 0,09828015 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04630391 0,09819484 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04630391 0,09810967 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04630391 0,09802465 ! meiotic prophase I GO:0007128 14 8 0,000 0,04630391 0,09793979 ! response to zinc ion GO:0010043 12 8 0,000 0,04630391 0,09785506 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04630391 0,09777049 ! oligopeptide transport GO:0006857 16 8 0,000 0,04630391 0,09768606 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04630391 0,09760177 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04630391 0,09751763 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04630391 0,09743364 ! signal peptide processing GO:0006465 12 8 0,000 0,04630391 0,09734979 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04630391 0,09726608 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04630391 0,09718252 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04630391 0,0970991 ! succinate metabolic process GO:0006105 17 8 0,000 0,04630391 0,09701582 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04630391 0,09693269 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04630391 0,0968497 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04630391 0,09676685 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04630391 0,09668415 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04630391 0,09660158 ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04630391 0,09651916 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04630391 0,09643687 ! reflex GO:0060004 17 8 0,000 0,04630391 0,09635473 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04630391 0,09627272 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,04630391 0,09619086 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04630391 0,09610913 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04630391 0,09602755 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04630391 0,0959461 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04630391 0,09586479 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04630391 0,09578362 ! histidine catabolic process GO:0006548 10 8 0,000 0,04630391 0,09570258 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04630391 0,09562168 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04630391 0,09554092 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,04630391 0,0954603 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04630391 0,09537981 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04630391 0,09529945 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,04630391 0,09521924 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04630391 0,09513915 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04630391 0,0950592 ! macrophage activation GO:0042116 13 8 0,000 0,04630391 0,09497939 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04630391 0,09489971 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04630391 0,09482016 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04630391 0,09474075 ! purine salvage GO:0043101 12 8 0,000 0,04630391 0,09466147 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04630391 0,09458232 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04630391 0,0945033 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04630391 0,09442442 ! osteoblast development GO:0002076 17 8 0,000 0,04630391 0,09434566 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04630391 0,09426704 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04630391 0,09418855 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04630391 0,09411019 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04630391 0,09403196 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04630391 0,09395386 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04630391 0,09387589 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04630391 0,09379805 ! intermediate filament organization GO:0045109 12 8 0,000 0,04630391 0,09372034 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04630391 0,09364276 ! cellular extravasation GO:0045123 13 8 0,000 0,04630391 0,0935653 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04630391 0,09348798 ! response to antibiotic GO:0046677 11 8 0,000 0,04630391 0,09341078 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04630391 0,09333371 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04630391 0,09325676 ! DNA topological change GO:0006265 12 8 0,000 0,04630391 0,09317994 ! response to tropane GO:0014073 15 8 0,000 0,04630391 0,09310325 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04630391 0,09302669 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04630391 0,09295025 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04630391 0,09287393 ! mast cell activation GO:0045576 14 8 0,000 0,04630391 0,09279775 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04630391 0,09272168 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04630391 0,09264574 ! gas homeostasis GO:0033483 14 8 0,000 0,04630391 0,09256993 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,04630391 0,09249424 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04630391 0,09241867 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04630391 0,09234323 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04630391 0,09226791 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04630391 0,09219271 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04630391 0,09211763 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04630391 0,09204268 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04630391 0,09196785 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04630391 0,09189314 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04630391 0,09181855 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04630391 0,09174408 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,04630391 0,09166973 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04630391 0,09159551 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04630391 0,0915214 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04630391 0,09144741 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04630391 0,09137355 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04630391 0,0912998 ! hormone catabolic process GO:0042447 17 8 0,000 0,04630391 0,09122617 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04630391 0,09115266 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04630391 0,09107927 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04630391 0,09100599 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04630391 0,09093284 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04630391 0,0908598 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04630391 0,09078688 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04630391 0,09071408 ! ATP catabolic process GO:0006200 11 8 0,000 0,04630391 0,09064139 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04630391 0,09056882 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04630391 0,09049636 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04630391 0,09042402 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04630391 0,0903518 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04630391 0,09027969 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04630391 0,0902077 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04630391 0,09013582 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04630391 0,09006405 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04630391 0,0899924 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04630391 0,08992087 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04630391 0,08984945 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04630391 0,08977814 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04630391 0,08970694 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04630391 0,08963586 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04630391 0,08956489 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04630391 0,08949403 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04630391 0,08942328 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04630391 0,08935265 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04630391 0,08928212 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04630391 0,08921171 ! establishment of organelle localization GO:0051656 122 59 1,000 0,04771103 0,09185032 ! lipid modification GO:0030258 112 60 1,000 0,04916895 0,09458248 ! adult behavior GO:0030534 104 60 1,000 0,04916895 0,09450806 ! kidney development GO:0001822 133 60 1,000 0,04916895 0,09443376 ! regulation of cellular component size GO:0032535 125 61 1,000 0,05064289 0,0971882 ! camera-type eye development GO:0043010 126 61 1,000 0,05064289 0,09711191 ! negative regulation of response to stimulus GO:0048585 106 61 1,000 0,05064289 0,09703575 ! axon extension GO:0048675 16 9 0,000 0,05193978 0,09944269 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,05193978 0,09936482 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,05193978 0,09928707 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,05193978 0,09920944 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05193978 0,09913193 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,05193978 0,09905455 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,05193978 0,09897728 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,05193978 0,09890014 ! reproductive behavior GO:0019098 22 9 0,000 0,05193978 0,09882311 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05193978 0,09874621 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,05193978 0,09866942 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,05193978 0,09859275 ! UTP metabolic process GO:0046051 10 9 0,000 0,05193978 0,09851621 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,05193978 0,09843978 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,05193978 0,09836347 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,05193978 0,09828728 ! artery development GO:0060840 25 9 0,000 0,05193978 0,0982112 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,05193978 0,09813525 ! regulation of glycolysis GO:0006110 20 9 0,000 0,05193978 0,09805941 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,05193978 0,09798369 ! equilibrioception GO:0050957 20 9 0,000 0,05193978 0,09790808 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,05193978 0,09783259 ! chemosensory behavior GO:0007635 21 9 0,000 0,05193978 0,09775722 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,05193978 0,09768197 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05193978 0,09760683 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,05193978 0,0975318 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,05193978 0,09745689 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,05193978 0,0973821 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,05193978 0,09730742 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05193978 0,09723285 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05193978 0,0971584 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,05193978 0,09708407 ! protein targeting to ER GO:0045047 25 9 0,000 0,05193978 0,09700984 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,05193978 0,09693573 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,05193978 0,09686174 ! glycine catabolic process GO:0006546 15 9 0,000 0,05193978 0,09678785 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,05193978 0,09671408 ! endosome organization GO:0007032 20 9 0,000 0,05193978 0,09664042 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05193978 0,09656688 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,05193978 0,09649344 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05193978 0,09642012 ! mannose metabolic process GO:0006013 13 9 0,000 0,05193978 0,09634691 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,05193978 0,09627381 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,05193978 0,09620082 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,05193978 0,09612794 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,05193978 0,09605517 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05193978 0,09598251 ! retinol metabolic process GO:0042572 20 9 0,000 0,05193978 0,09590996 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,05193978 0,09583752 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,05193978 0,09576519 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,05193978 0,09569297 ! macrophage differentiation GO:0030225 15 9 0,000 0,05193978 0,09562086 ! oligodendrocyte development GO:0014003 11 9 0,000 0,05193978 0,09554885 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05193978 0,09547696 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,05193978 0,09540517 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05193978 0,09533349 ! response to amine stimulus GO:0014075 13 9 0,000 0,05193978 0,09526192 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05193978 0,09519045 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,05193978 0,0951191 ! erythrocyte development GO:0048821 17 9 0,000 0,05193978 0,09504785 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05193978 0,0949767 ! renal water homeostasis GO:0003091 15 9 0,000 0,05193978 0,09490567 ! postreplication repair GO:0006301 25 9 0,000 0,05193978 0,09483474 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,05193978 0,09476391 ! icosanoid secretion GO:0032309 15 9 0,000 0,05193978 0,09469319 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05193978 0,09462258 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,05193978 0,09455207 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,05193978 0,09448166 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,05193978 0,09441137 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05193978 0,09434117 ! sterol catabolic process GO:0016127 14 9 0,000 0,05193978 0,09427108 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05193978 0,0942011 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,05193978 0,09413121 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,05193978 0,09406143 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,05193978 0,09399176 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,05193978 0,09392219 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,05193978 0,09385272 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,05193978 0,09378335 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,05193978 0,09371409 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,05193978 0,09364493 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05193978 0,09357587 ! purine base metabolic process GO:0006144 25 9 0,000 0,05193978 0,09350691 ! pigment granule transport GO:0051904 17 9 0,000 0,05193978 0,09343805 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,05193978 0,0933693 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,05193978 0,09330064 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05193978 0,09323209 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,05193978 0,09316364 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,05193978 0,09309529 ! mitochondrion localization GO:0051646 18 9 0,000 0,05193978 0,09302703 ! regulation of protein complex assembly GO:0043254 132 63 1,000 0,05363787 0,09599803 ! regulation of mitosis GO:0007088 112 63 1,000 0,05363787 0,09592776 GO:0051783|regulation of nuclear division, ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,0566941 0,10131945 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,0566941 0,10124539 GO:0048609|reproductive process in a multicellular organism, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,0575425 0,10268541 ! regulation of developmental growth GO:0048638 16 10 0,000 0,0575425 0,10261045 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,0575425 0,10253561 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,0575425 0,10246087 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,0575425 0,10238625 ! associative learning GO:0008306 21 10 0,000 0,0575425 0,10231173 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0575425 0,10223732 ! phosphate transport GO:0006817 24 10 0,000 0,0575425 0,10216302 ! cell volume homeostasis GO:0006884 17 10 0,000 0,0575425 0,10208883 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,0575425 0,10201475 ! CTP metabolic process GO:0046036 11 10 0,000 0,0575425 0,10194077 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,0575425 0,1018669 ! GTP metabolic process GO:0046039 11 10 0,000 0,0575425 0,10179314 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,0575425 0,10171948 GO:0007520|myoblast fusion, ! social behavior GO:0035176 29 10 0,000 0,0575425 0,10164593 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,0575425 0,10157249 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,0575425 0,10149915 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,0575425 0,10142592 ! androgen metabolic process GO:0008209 17 10 0,000 0,0575425 0,10135279 ! phospholipid efflux GO:0033700 19 10 0,000 0,0575425 0,10127977 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,0575425 0,10120685 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,0575425 0,10113404 ! lung alveolus development GO:0048286 26 10 0,000 0,0575425 0,10106134 ! pathogenesis GO:0009405 17 10 0,000 0,0575425 0,10098874 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0575425 0,10091624 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,0575425 0,10084384 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,0575425 0,10077156 ! endoderm development GO:0007492 18 10 0,000 0,0575425 0,10069937 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,0575425 0,10062729 ! arginine catabolic process GO:0006527 17 10 0,000 0,0575425 0,10055531 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0575425 0,10048343 ! proline metabolic process GO:0006560 13 10 0,000 0,0575425 0,10041166 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,0575425 0,10033999 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,0575425 0,10026842 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,0575425 0,10019695 ! V(D)J recombination GO:0033151 34 10 0,000 0,0575425 0,10012558 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,0575425 0,10005432 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,0575425 0,09998316 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,0575425 0,0999121 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,0575425 0,09984114 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,0575425 0,09977028 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,0575425 0,09969952 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,0575425 0,09962886 ! ruffle organization GO:0031529 17 10 0,000 0,0575425 0,0995583 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,0575425 0,09948784 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0575425 0,09941748 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,0575425 0,09934722 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,0575425 0,09927706 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,0575425 0,099207 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,0575425 0,09913704 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,0575425 0,09906717 ! regulation of bone resorption GO:0045124 25 10 0,000 0,0575425 0,09899741 ! protein heterooligomerization GO:0051291 17 10 0,000 0,0575425 0,09892774 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,0575425 0,09885817 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,0575425 0,0987887 ! segment specification GO:0007379 15 10 0,000 0,0575425 0,09871933 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,0575425 0,09865005 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,0575425 0,09858087 ! blastoderm segmentation GO:0007350 19 10 0,000 0,0575425 0,09851179 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,0575425 0,0984428 ! response to dsRNA GO:0043331 23 10 0,000 0,0575425 0,09837391 ! DNA ligation GO:0006266 18 10 0,000 0,0575425 0,09830512 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0575425 0,09823642 ! melanosome localization GO:0032400 16 10 0,000 0,0575425 0,09816782 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,0575425 0,09809932 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,0575425 0,09803091 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,0575425 0,09796259 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0575425 0,09789437 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,0575425 0,09782625 ! induction of an organ GO:0001759 17 10 0,000 0,0575425 0,09775822 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,0575425 0,09769028 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,0575425 0,09762244 ! protein sumoylation GO:0016925 17 10 0,000 0,0575425 0,0975547 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,0575425 0,09748705 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0575425 0,09741949 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0575425 0,09735202 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0575425 0,09728465 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,0575425 0,09721737 ! salivary gland development GO:0007431 28 10 0,000 0,0575425 0,09715019 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,0575425 0,09708309 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,0575425 0,09701609 ! midbrain development GO:0030901 14 10 0,000 0,0575425 0,09694919 ! musculoskeletal movement GO:0050881 16 10 0,000 0,0575425 0,09688237 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,0575425 0,09681565 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,0575425 0,09674902 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,0575425 0,09668248 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,0575425 0,09661603 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,0575425 0,09654967 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0575425 0,0964834 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0575425 0,09641723 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,0575425 0,09635114 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,0575425 0,09628515 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,0575425 0,09621925 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0575425 0,09615343 ! blastocyst formation GO:0001825 18 10 0,000 0,0575425 0,09608771 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,0575425 0,09602208 ! cerebellar cortex development GO:0021695 16 10 0,000 0,0575425 0,09595653 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,0575425 0,09589108 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,0575425 0,09582571 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,0575425 0,09576044 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,0575425 0,09569525 ! activation of MAPK activity GO:0000187 124 67 1,000 0,05980974 0,09939809 ! chromosome segregation GO:0007059 127 67 1,000 0,05980974 0,09933052 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 1,000 0,05980974 0,09926304 ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,05980974 0,09919565 ! secondary metabolic process GO:0019748 125 67 1,000 0,05980974 0,09912835 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,06138927 0,10167728 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,06138927 0,10160839 ! hexose catabolic process GO:0019320 113 68 1,000 0,06138927 0,10153959 ! detection of external stimulus GO:0009581 102 68 1,000 0,06138927 0,10147089 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,06138927 0,10140229 ! regulation of lipase activity GO:0060191 137 68 1,000 0,06138927 0,10133377 ! cell projection assembly GO:0030031 138 68 1,000 0,06138927 0,10126535 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,06298297 0,10382416 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,06311226 0,10396713 ! respiratory burst GO:0045730 17 11 0,000 0,06311226 0,10389707 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,06311226 0,10382711 ! neuron fate specification GO:0048665 18 11 0,000 0,06311226 0,10375724 ! telencephalon cell migration GO:0022029 23 11 0,000 0,06311226 0,10368746 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,06311226 0,10361778 ! thyroid gland development GO:0030878 26 11 0,000 0,06311226 0,10354819 ! synapsis GO:0007129 14 11 0,000 0,06311226 0,1034787 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,06311226 0,1034093 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,06311226 0,10333999 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,06311226 0,10327077 ! response to pain GO:0048265 27 11 0,000 0,06311226 0,10320165 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,06311226 0,10313261 ! blood vessel remodeling GO:0001974 30 11 0,000 0,06311226 0,10306368 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,06311226 0,10299483 ! bone resorption GO:0045453 16 11 0,000 0,06311226 0,10292607 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,06311226 0,10285741 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06311226 0,10278884 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06311226 0,10272036 ! melanocyte differentiation GO:0030318 20 11 0,000 0,06311226 0,10265197 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,06311226 0,10258367 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,06311226 0,10251546 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,06311226 0,10244735 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,06311226 0,10237932 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,06311226 0,10231139 ! UV protection GO:0009650 20 11 0,000 0,06311226 0,10224354 ! adult heart development GO:0007512 16 11 0,000 0,06311226 0,10217578 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,06311226 0,10210812 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06311226 0,10204054 ! macroautophagy GO:0016236 19 11 0,000 0,06311226 0,10197305 ! temperature homeostasis GO:0001659 18 11 0,000 0,06311226 0,10190566 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,06311226 0,10183835 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,06311226 0,10177113 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,06311226 0,101704 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,06311226 0,10163695 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,06311226 0,10157 ! regulation of organ growth GO:0046620 14 11 0,000 0,06311226 0,10150313 ! pigment granule localization GO:0051875 20 11 0,000 0,06311226 0,10143635 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,06311226 0,10136966 ! vasoconstriction GO:0042310 20 11 0,000 0,06311226 0,10130306 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,06311226 0,10123655 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06311226 0,10117012 ! embryonic axis specification GO:0000578 19 11 0,000 0,06311226 0,10110378 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,06311226 0,10103752 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06311226 0,10097135 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,06311226 0,10090527 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,06311226 0,10083928 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,06311226 0,10077337 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,06311226 0,10070755 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,06311226 0,10064181 ! prophase GO:0051324 17 11 0,000 0,06311226 0,10057616 ! neuroblast proliferation GO:0007405 25 11 0,000 0,06311226 0,1005106 ! nucleosome positioning GO:0016584 15 11 0,000 0,06311226 0,10044512 ! regulation of isotype switching GO:0045191 24 11 0,000 0,06311226 0,10037973 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,06311226 0,10031442 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,06311226 0,10024919 ! apical protein localization GO:0045176 18 11 0,000 0,06311226 0,10018405 ! acid secretion GO:0046717 20 11 0,000 0,06311226 0,100119 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06311226 0,10005403 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,06311226 0,09998914 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,06311226 0,09992434 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,06311226 0,09985962 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,06311226 0,09979499 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,06311226 0,09973044 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,06311226 0,09966597 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06311226 0,09960159 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,06311226 0,09953729 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,06311226 0,09947307 ! embryonic gut development GO:0048566 19 11 0,000 0,06311226 0,09940894 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,06311226 0,09934488 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,06311226 0,09928091 ! activation of innate immune response GO:0002218 16 11 0,000 0,06311226 0,09921703 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,06311226 0,09915322 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,06311226 0,0990895 ! lysogeny GO:0030069 22 11 0,000 0,06311226 0,09902586 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06311226 0,0989623 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,06311226 0,09889882 ! sequestering of metal ion GO:0051238 15 11 0,000 0,06311226 0,09883542 ! regulation of embryonic development GO:0045995 35 11 0,000 0,06311226 0,09877211 ! nucleus localization GO:0051647 22 11 0,000 0,06311226 0,09870887 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,06621203 0,10349072 ! carbohydrate transport GO:0008643 114 72 1,000 0,06784695 0,10597832 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,06784695 0,1059106 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06864927 0,10709461 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06864927 0,10702627 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,06864927 0,10695801 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06864927 0,10688984 ! virus-host interaction GO:0019048 30 12 0,000 0,06864927 0,10682176 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,06864927 0,10675376 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,06864927 0,10668585 ! protein complex disassembly GO:0043241 28 12 0,000 0,06864927 0,10661803 GO:0043624|cellular protein complex disassembly, ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,06864927 0,10655029 ! hippocampus development GO:0021766 29 12 0,000 0,06864927 0,10648264 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06864927 0,10641508 ! T cell proliferation GO:0042098 32 12 0,000 0,06864927 0,1063476 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06864927 0,10628021 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06864927 0,1062129 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06864927 0,10614567 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06864927 0,10607854 ! drug transport GO:0015893 16 12 0,000 0,06864927 0,10601148 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06864927 0,10594451 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06864927 0,10587763 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,06864927 0,10581083 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06864927 0,10574411 ! mitotic spindle organization GO:0007052 23 12 0,000 0,06864927 0,10567748 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06864927 0,10561093 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06864927 0,10554447 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06864927 0,10547809 ! lipid digestion GO:0044241 21 12 0,000 0,06864927 0,10541179 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06864927 0,10534558 ! entry into host cell GO:0030260 34 12 0,000 0,06864927 0,10527945 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06864927 0,1052134 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06864927 0,10514744 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06864927 0,10508156 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06864927 0,10501576 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06864927 0,10495004 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06864927 0,10488441 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06864927 0,10481885 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06864927 0,10475338 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06864927 0,10468799 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06864927 0,10462268 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06864927 0,10455746 ! cranial nerve development GO:0021545 23 12 0,000 0,06864927 0,10449231 ! fucose catabolic process GO:0019317 25 12 0,000 0,06864927 0,10442725 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06864927 0,10436227 ! autonomic nervous system development GO:0048483 24 12 0,000 0,06864927 0,10429737 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,06864927 0,10423254 ! zymogen activation GO:0031638 18 12 0,000 0,06864927 0,1041678 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06864927 0,10410314 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06864927 0,10403856 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,06864927 0,10397406 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06864927 0,10390964 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06864927 0,1038453 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,06864927 0,10378104 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06864927 0,10371686 ! defense response to fungus GO:0050832 15 12 0,000 0,06864927 0,10365276 ! developmental induction GO:0031128 22 12 0,000 0,06864927 0,10358874 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,06864927 0,10352479 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06864927 0,10346093 ! response to cold GO:0009409 17 12 0,000 0,06864927 0,10339714 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06864927 0,10333343 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06864927 0,10326981 ! humoral immune response GO:0006959 115 73 1,000 0,06949517 0,10447797 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,07115648 0,10690977 ! organelle localization GO:0051640 155 74 1,000 0,07115648 0,10684406 ! eye development GO:0001654 155 75 1,000 0,07283068 0,10929075 ! axon guidance GO:0007411 162 75 1,000 0,07283068 0,10922366 ! rhythmic process GO:0048511 142 75 1,000 0,07283068 0,10915666 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,07415371 0,11107143 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07415371 0,11100337 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,07415371 0,1109354 ! regulation of chemokine production GO:0032642 18 13 0,000 0,07415371 0,11086751 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,07415371 0,1107997 ! peroxisomal transport GO:0043574 28 13 0,000 0,07415371 0,11073197 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,07415371 0,11066433 ! cartilage condensation GO:0001502 22 13 0,000 0,07415371 0,11059677 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,07415371 0,11052929 ! organelle fusion GO:0048284 36 13 0,000 0,07415371 0,11046189 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,07415371 0,11039458 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,07415371 0,11032735 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,07415371 0,1102602 ! endocrine pancreas development GO:0031018 25 13 0,000 0,07415371 0,11019313 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,07415371 0,11012614 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,07415371 0,11005924 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,07415371 0,10999241 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,07415371 0,10992567 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,07415371 0,10985901 ! methionine metabolic process GO:0006555 31 13 0,000 0,07415371 0,10979243 ! plasma membrane organization GO:0007009 27 13 0,000 0,07415371 0,10972593 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,07415371 0,10965951 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,07415371 0,10959317 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,07415371 0,10952691 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,07415371 0,10946073 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,07415371 0,10939463 ! exocrine system development GO:0035272 34 13 0,000 0,07415371 0,10932861 ! asymmetric protein localization GO:0008105 24 13 0,000 0,07415371 0,10926267 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,07415371 0,10919681 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,07415371 0,10913103 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,07415371 0,10906532 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,07415371 0,1089997 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,07415371 0,10893416 ! protein homotetramerization GO:0051289 24 13 0,000 0,07415371 0,10886869 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,07415371 0,10880331 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,07415371 0,108738 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,07415371 0,10867277 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,07415371 0,10860762 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,07415371 0,10854254 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07415371 0,10847755 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,07415371 0,10841263 ! histone methylation GO:0016571 29 13 0,000 0,07415371 0,10834779 ! chromatin silencing GO:0006342 29 13 0,000 0,07415371 0,10828303 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,07415371 0,10821834 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,07415371 0,10815373 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07415371 0,1080892 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,07415371 0,10802475 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,07415371 0,10796037 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,07415371 0,10789607 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,07415371 0,10783185 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,07415371 0,1077677 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,07415371 0,10770363 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,07415371 0,10763963 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07415371 0,10757571 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,07415371 0,10751187 ! insulin secretion GO:0030073 24 13 0,000 0,07415371 0,1074481 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,07415371 0,10738441 ! acrosome reaction GO:0007340 19 13 0,000 0,07415371 0,1073208 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,07415371 0,10725725 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,07451755 0,10771975 ! regulation of blood pressure GO:0008217 134 76 1,000 0,07451755 0,10765604 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,07621689 0,11004601 ! monosaccharide catabolic process GO:0046365 125 77 1,000 0,07621689 0,10998101 ! rRNA transcription GO:0009303 28 14 0,000 0,07962576 0,1148322 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,07962576 0,11476445 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,07962576 0,11469678 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,07962576 0,11462919 ! non-recombinational repair GO:0000726 29 14 0,000 0,07962576 0,11456169 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,07962576 0,11449426 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,07962576 0,11442691 ! lipid localization GO:0010876 32 14 0,000 0,07962576 0,11435964 GO:0019915|lipid storage, ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,07962576 0,11429245 ! regulated secretory pathway GO:0045055 24 14 0,000 0,07962576 0,11422533 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,07962576 0,1141583 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,07962576 0,11409134 ! arginine metabolic process GO:0006525 21 14 0,000 0,07962576 0,11402447 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,07962576 0,11395767 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,07962576 0,11389095 ! regulation of heart rate GO:0002027 25 14 0,000 0,07962576 0,11382431 ! organic alcohol transport GO:0015850 29 14 0,000 0,07962576 0,11375774 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,07962576 0,11369126 ! embryo implantation GO:0007566 30 14 0,000 0,07962576 0,11362485 ! neutral amino acid transport GO:0015804 28 14 0,000 0,07962576 0,11355852 ! bone mineralization GO:0030282 18 14 0,000 0,07962576 0,11349227 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,07962576 0,11342609 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,07962576 0,11335999 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,07962576 0,11329397 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,07962576 0,11322802 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,07962576 0,11316215 ! ribosome assembly GO:0042255 18 14 0,000 0,07962576 0,11309636 ! cerebellum development GO:0021549 23 14 0,000 0,07962576 0,11303065 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,07962576 0,11296501 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,07962576 0,11289944 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,07962576 0,11283396 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,07962576 0,11276855 ! NADP metabolic process GO:0006739 24 14 0,000 0,07962576 0,11270321 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,07962576 0,11263795 ! oxygen transport GO:0015671 22 14 0,000 0,07962576 0,11257277 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07962576 0,11250766 ! male genitalia development GO:0030539 26 14 0,000 0,07962576 0,11244263 ! regulation of RNA stability GO:0043487 33 14 0,000 0,07962576 0,11237767 ! regulation of axon extension GO:0030516 43 14 0,000 0,07962576 0,11231278 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,07962576 0,11224798 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,07965215 0,11222041 ! steroid biosynthetic process GO:0006694 146 79 1,000 0,07965215 0,11215573 ! protein import into nucleus GO:0006606 174 82 1,000 0,08489349 0,11946705 ! lactation GO:0007595 30 15 0,000 0,08506563 0,11964038 ! reproductive cellular process GO:0048610 22 15 0,000 0,08506563 0,11957155 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08506563 0,11950279 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,08506563 0,11943411 ! superoxide anion generation GO:0042554 22 15 0,000 0,08506563 0,11936551 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,08506563 0,11929698 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,08506563 0,11922854 ! copper ion transport GO:0006825 22 15 0,000 0,08506563 0,11916018 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,08506563 0,11909189 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,08506563 0,11902368 ! sulfate transport GO:0008272 27 15 0,000 0,08506563 0,11895555 ! response to cAMP GO:0051591 25 15 0,000 0,08506563 0,1188875 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,08506563 0,11881952 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,08506563 0,11875163 ! response to hexose stimulus GO:0009746 25 15 0,000 0,08506563 0,11868381 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,08506563 0,11861607 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,08506563 0,1185484 ! vesicle coating GO:0006901 38 15 0,000 0,08506563 0,11848081 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,08506563 0,1184133 ! regulation of exocytosis GO:0017157 26 15 0,000 0,08506563 0,11834587 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,08506563 0,11827851 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,08506563 0,11821123 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,08506563 0,11814403 ! regulation of vasodilation GO:0042312 27 15 0,000 0,08506563 0,1180769 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,08506563 0,11800985 ! histone deacetylation GO:0016575 24 15 0,000 0,08506563 0,11794288 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,08506563 0,11787598 ! water homeostasis GO:0030104 28 15 0,000 0,08506563 0,11780915 ! cofactor transport GO:0051181 30 15 0,000 0,08506563 0,11774241 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08506563 0,11767573 ! muscle maintenance GO:0046716 26 15 0,000 0,08506563 0,11760914 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,08506563 0,11754262 ! intestinal absorption GO:0050892 31 15 0,000 0,08506563 0,11747617 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08506563 0,1174098 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,08506563 0,1173435 ! heme biosynthetic process GO:0006783 33 15 0,000 0,08506563 0,11727728 ! cell killing GO:0001906 32 15 0,000 0,08506563 0,11721114 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,08506563 0,11714507 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,08506563 0,11707907 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,08506563 0,11701315 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,08506563 0,1169473 ! actin filament polymerization GO:0030041 27 15 0,000 0,08506563 0,11688152 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,08506563 0,11681582 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,0866634 0,11894309 ! nuclear import GO:0051170 177 83 1,000 0,0866634 0,1188763 ! inorganic anion transport GO:0015698 156 83 1,000 0,0866634 0,11880959 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,09023627 0,12363836 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,09023627 0,12356906 ! positive regulation of cell size GO:0045793 29 16 0,000 0,0904735 0,12382452 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,0904735 0,12375519 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,0904735 0,12368594 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,0904735 0,12361676 ! bone remodeling GO:0046849 28 16 0,000 0,0904735 0,12354767 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,0904735 0,12347864 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0904735 0,1234097 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,0904735 0,12334083 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,0904735 0,12327204 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,0904735 0,12320333 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,0904735 0,12313469 ! startle response GO:0001964 28 16 0,000 0,0904735 0,12306613 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,0904735 0,12299765 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,0904735 0,12292924 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,0904735 0,12286091 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,0904735 0,12279265 ! protein polyubiquitination GO:0000209 41 16 0,000 0,0904735 0,12272447 ! glutamate metabolic process GO:0006536 25 16 0,000 0,0904735 0,12265637 ! pituitary gland development GO:0021983 30 16 0,000 0,0904735 0,12258834 ! response to osmotic stress GO:0006970 27 16 0,000 0,0904735 0,12252038 ! lysosomal transport GO:0007041 31 16 0,000 0,0904735 0,12245251 ! fructose metabolic process GO:0006000 25 16 0,000 0,0904735 0,1223847 ! L-amino acid transport GO:0015807 33 16 0,000 0,0904735 0,12231697 ! stem cell development GO:0048864 46 16 0,000 0,0904735 0,12224932 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,0904735 0,12218174 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,0904735 0,12211424 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,0904735 0,12204681 ! negative regulation of immune response GO:0050777 38 16 0,000 0,0904735 0,12197946 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,0904735 0,12191217 ! DNA replication initiation GO:0006270 28 16 0,000 0,0904735 0,12184497 ! neuron recognition GO:0008038 40 16 0,000 0,0904735 0,12177784 ! mRNA splice site selection GO:0006376 44 16 0,000 0,0904735 0,12171078 ! tissue regeneration GO:0042246 27 16 0,000 0,0904735 0,12164379 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,0904735 0,12157688 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,0904735 0,12151005 ! biomineral formation GO:0031214 22 16 0,000 0,0904735 0,12144328 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,0904735 0,12137659 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,0904735 0,12130997 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,0904735 0,12124343 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,0904735 0,12117696 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,0904735 0,12111056 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,0904735 0,12104423 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,0904735 0,12097798 ! peptide hormone processing GO:0016486 27 16 0,000 0,0904735 0,1209118 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,09203884 0,12293651 ! regulation of lyase activity GO:0051339 169 86 1,000 0,09203884 0,12286933 ! alcohol catabolic process GO:0046164 142 87 1,000 0,09385191 0,12522131 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,09567531 0,12758449 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,09584956 0,12774713 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,09584956 0,12767747 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,09584956 0,12760789 ! filopodium assembly GO:0046847 42 17 0,000 0,09584956 0,12753839 ! gene silencing by RNA GO:0031047 38 17 0,000 0,09584956 0,12746896 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,09584956 0,12739961 ! glial cell development GO:0021782 28 17 0,000 0,09584956 0,12733033 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,09584956 0,12726113 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,09584956 0,127192 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,09584956 0,12712295 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,09584956 0,12705398 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,09584956 0,12698508 ! myoblast differentiation GO:0045445 50 17 0,000 0,09584956 0,12691625 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,09584956 0,1268475 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,09584956 0,12677882 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,09584956 0,12671022 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,09584956 0,12664169 ! NAD metabolic process GO:0019674 33 17 0,000 0,09584956 0,12657323 ! membrane budding GO:0006900 42 17 0,000 0,09584956 0,12650485 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,09584956 0,12643654 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,09584956 0,12636831 ! genitalia development GO:0048806 32 17 0,000 0,09584956 0,12630015 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,09584956 0,12623207 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,09584956 0,12616405 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,09584956 0,12609611 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,09584956 0,12602825 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,09584956 0,12596045 ! steroid catabolic process GO:0006706 34 17 0,000 0,09584956 0,12589273 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,09584956 0,12582508 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,09584956 0,12575751 ! gas transport GO:0015669 26 17 0,000 0,09584956 0,12569001 ! organic cation transport GO:0015695 32 17 0,000 0,09584956 0,12562258 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,09584956 0,12555522 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,09750885 0,12766031 ! protein localization in nucleus GO:0034504 192 89 1,000 0,09750885 0,12759193 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,09935235 0,12993458 ! response to unfolded protein GO:0006986 139 90 1,000 0,09935235 0,12986506 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,10119399 0,13220156 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,10119399 0,13213091 ! limbic system development GO:0021761 40 18 0,000 0,10119399 0,13206032 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,10119399 0,13198982 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,10119399 0,13191938 ! adult walking behavior GO:0007628 36 18 0,000 0,10119399 0,13184903 ! heart looping GO:0001947 34 18 0,000 0,10119399 0,13177874 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,10119399 0,13170854 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,10119399 0,13163841 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,10119399 0,13156835 ! glycine metabolic process GO:0006544 30 18 0,000 0,10119399 0,13149836 ! glutamine metabolic process GO:0006541 29 18 0,000 0,10119399 0,13142846 ! response to retinoic acid GO:0032526 31 18 0,000 0,10119399 0,13135862 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,10119399 0,13128886 ! DNA integration GO:0015074 32 18 0,000 0,10119399 0,13121917 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,10119399 0,13114956 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,10119399 0,13108002 ! neural crest cell migration GO:0001755 41 18 0,000 0,10119399 0,13101056 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,10119399 0,13094117 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,10119399 0,13087185 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,10119399 0,13080261 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,10119399 0,13073343 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,10119399 0,13066434 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,10119399 0,13059531 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,10119399 0,13052636 ! detection of bacterium GO:0016045 22 18 0,000 0,10119399 0,13045748 ! nerve development GO:0021675 34 18 0,000 0,10119399 0,13038867 ! microspike assembly GO:0030035 46 18 0,000 0,10119399 0,13031994 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,10119399 0,13025128 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,10120562 0,13019765 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,10650698 0,13694556 ! positive regulation of translation GO:0045727 31 19 0,000 0,10650698 0,13687352 ! negative regulation of defense response GO:0031348 27 19 0,000 0,10650698 0,13680156 ! neuron maturation GO:0042551 46 19 0,000 0,10650698 0,13672967 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,10650698 0,13665786 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,10650698 0,13658612 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,10650698 0,13651446 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,10650698 0,13644287 ! inositol metabolic process GO:0006020 33 19 0,000 0,10650698 0,13637136 ! memory GO:0007613 34 19 0,000 0,10650698 0,13629993 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,10650698 0,13622856 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,10650698 0,13615728 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,10650698 0,13608607 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,10650698 0,13601493 ! cerebral cortex development GO:0021987 40 19 0,000 0,10650698 0,13594387 ! pigmentation during development GO:0048066 42 19 0,000 0,10650698 0,13587288 ! response to vitamin A GO:0033189 32 19 0,000 0,10650698 0,13580196 ! heme metabolic process GO:0042168 40 19 0,000 0,10650698 0,13573112 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,10650698 0,13566035 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,10650698 0,13558966 ! response to fungus GO:0009620 26 19 0,000 0,10650698 0,13551904 ! peptide cross-linking GO:0018149 39 19 0,000 0,10650698 0,13544849 ! protein export from nucleus GO:0006611 40 19 0,000 0,10650698 0,13537802 ! heart process GO:0003015 32 19 0,000 0,10650698 0,13530762 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,10650698 0,1352373 ! visual learning GO:0008542 38 19 0,000 0,10650698 0,13516704 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,10650698 0,13509686 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,10650698 0,13502676 ! vitamin transport GO:0051180 31 19 0,000 0,10650698 0,13495672 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,10650698 0,13488676 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,10650698 0,13481687 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,10650698 0,13474705 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,10650698 0,13467731 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,10650698 0,13460763 ! cilium assembly GO:0042384 38 19 0,000 0,10650698 0,13453803 ! peptide hormone secretion GO:0030072 32 19 0,000 0,10650698 0,13446851 ! female pregnancy GO:0007565 166 94 1,000 0,10682233 0,13479698 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,10871294 0,13711188 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,10871294 0,13704113 ! protein secretion GO:0009306 45 20 0,000 0,11178871 0,14084571 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,11178871 0,14077311 ! positive regulation of ossification GO:0045778 50 20 0,000 0,11178871 0,14070058 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,11178871 0,14062813 ! skin development GO:0043588 42 20 0,000 0,11178871 0,14055575 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,11178871 0,14048345 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,11178871 0,14041122 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,11178871 0,14033907 ! response to vitamin GO:0033273 36 20 0,000 0,11178871 0,14026699 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,11178871 0,14019498 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,11178871 0,14012305 ! retinoid metabolic process GO:0001523 34 20 0,000 0,11178871 0,14005119 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,11178871 0,13997941 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,11178871 0,1399077 ! body fluid secretion GO:0007589 33 20 0,000 0,11178871 0,13983606 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,11178871 0,1397645 ! peptide secretion GO:0002790 38 20 0,000 0,11178871 0,13969301 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,11178871 0,13962159 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,11178871 0,13955025 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,11178871 0,13947897 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,11178871 0,13940777 ! cell-cell junction organization GO:0045216 43 20 0,000 0,11178871 0,13933665 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,11178871 0,13926559 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,11178871 0,13919461 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,11178871 0,1391237 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,11178871 0,13905287 ! regulation of glucose import GO:0046324 30 20 0,000 0,11178871 0,1389821 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,11178871 0,13891141 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,11178871 0,13884079 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,11178871 0,13877024 ! forebrain development GO:0030900 210 98 1,000 0,11443751 0,1419862 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,11443751 0,14191413 ! regulation of cell killing GO:0031341 46 21 0,000 0,11703937 0,14506707 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,11703937 0,1449935 ! hormone secretion GO:0046879 39 21 0,000 0,11703937 0,14492001 ! cAMP metabolic process GO:0046058 41 21 0,000 0,11703937 0,1448466 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,11703937 0,14477326 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,11703937 0,14469999 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,11703937 0,1446268 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,11703937 0,14455368 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,11703937 0,14448064 ! plasma membrane fusion GO:0045026 33 21 0,000 0,11703937 0,14440767 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,11703937 0,14433477 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,11703937 0,14426195 ! sensory perception of pain GO:0019233 33 21 0,000 0,11703937 0,1441892 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,11703937 0,14411653 ! diencephalon development GO:0021536 36 21 0,000 0,11703937 0,14404392 ! collagen fibril organization GO:0030199 62 21 0,000 0,11703937 0,14397139 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,11703937 0,14389894 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,11703937 0,14382655 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,11703937 0,14375424 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,11703937 0,143682 ! collagen catabolic process GO:0030574 29 21 0,000 0,11703937 0,14360984 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,11703937 0,14353774 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,11703937 0,14346572 ! sperm-egg recognition GO:0035036 23 21 0,000 0,11703937 0,14339377 ! actin filament-based movement GO:0030048 47 21 0,000 0,11703937 0,1433219 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,12225914 0,14963881 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,12225914 0,14956388 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,12225914 0,14948903 GO:0034105|positive regulation of tissue remodeling, ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,12225914 0,14941424 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,12225914 0,14933954 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,12225914 0,1492649 ! vacuolar transport GO:0007034 41 22 0,000 0,12225914 0,14919035 ! fucose metabolic process GO:0006004 44 22 0,000 0,12225914 0,14911586 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,12225914 0,14904145 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,12225914 0,14896712 ! stem cell differentiation GO:0048863 57 22 0,000 0,12225914 0,14889286 ! cytolysis GO:0019835 27 22 0,000 0,12225914 0,14881867 ! vasodilation GO:0042311 40 22 0,000 0,12225914 0,14874456 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,12225914 0,14867052 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,12225914 0,14859655 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,12225914 0,14852266 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,12225914 0,14844884 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,12225914 0,1483751 ! sarcomere organization GO:0045214 32 22 0,000 0,12225914 0,14830143 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,12225914 0,14822783 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,12225914 0,1481543 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,12225914 0,14808085 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,12225914 0,14800747 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,12744819 0,15421294 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,12744819 0,1541366 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,12744819 0,15406033 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,12744819 0,15398414 ! gluconeogenesis GO:0006094 38 23 0,000 0,12744819 0,15390802 ! glycerol metabolic process GO:0006071 40 23 0,000 0,12744819 0,15383198 ! viral genome replication GO:0019079 44 23 0,000 0,12744819 0,15375602 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,12744819 0,15368013 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,12744819 0,15360431 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,12744819 0,15352857 ! axis specification GO:0009798 43 23 0,000 0,12744819 0,1534529 ! visual behavior GO:0007632 46 23 0,000 0,12744819 0,15337731 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,12744819 0,15330179 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,12744819 0,15322635 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,12744819 0,15315098 ! peroxisome organization GO:0007031 43 23 0,000 0,12744819 0,15307568 ! lysosome organization GO:0007040 47 23 0,000 0,12744819 0,15300046 ! vesicle targeting GO:0006903 49 23 0,000 0,12744819 0,15292531 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,12744819 0,15285024 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,12744819 0,15277524 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,12744819 0,15270031 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,12744819 0,15262546 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,12744819 0,15255068 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,12744819 0,15247597 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,12744819 0,15240134 ! hormone transport GO:0009914 41 23 0,000 0,12744819 0,15232678 ! cell-cell recognition GO:0009988 28 23 0,000 0,12744819 0,15225229 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,12744819 0,15217788 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,12744819 0,15210353 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,12744819 0,15202926 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,13260671 0,15810552 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,13260671 0,15802839 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,13260671 0,15795134 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,13260671 0,15787437 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,13260671 0,15779747 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,13260671 0,15772064 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,13260671 0,15764389 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,13260671 0,15756722 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,13260671 0,15749062 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,13260671 0,15741409 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,13260671 0,15733764 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,13260671 0,15726126 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,13260671 0,15718496 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,13260671 0,15710873 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,13260671 0,15703258 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,13260671 0,15695649 ! membrane depolarization GO:0051899 45 24 0,000 0,13260671 0,15688049 ! pallium development GO:0021543 56 24 0,000 0,13260671 0,15680455 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,13260671 0,15672869 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,13260671 0,1566529 ! platelet activation GO:0030168 41 24 0,000 0,13260671 0,15657719 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,13260671 0,15650155 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,13260671 0,15642598 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,13260671 0,15635048 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,13260671 0,15627506 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,13260671 0,15619971 ! regulation of amine transport GO:0051952 41 24 0,000 0,13260671 0,15612444 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,13773488 0,16208397 ! leukocyte adhesion GO:0007159 55 25 0,000 0,13773488 0,16200593 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,13773488 0,16192797 ! phototransduction GO:0007602 37 25 0,000 0,13773488 0,16185008 ! keratinization GO:0031424 37 25 0,000 0,13773488 0,16177227 ! vacuole organization GO:0007033 49 25 0,000 0,13773488 0,16169453 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,13773488 0,16161687 ! chromosome condensation GO:0030261 48 25 0,000 0,13773488 0,16153928 ! regulation of behavior GO:0050795 48 25 0,000 0,13773488 0,16146177 ! interaction with host GO:0051701 66 25 0,000 0,13773488 0,16138433 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,13773488 0,16130696 ! immunoglobulin production GO:0002377 62 25 0,000 0,13773488 0,16122967 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,13773488 0,16115245 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,13773488 0,16107531 ! liver development GO:0001889 55 25 0,000 0,13773488 0,16099824 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,14283288 0,16687744 ! initiation of viral infection GO:0019059 60 26 0,000 0,14283288 0,16679767 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,14283288 0,16671798 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,14283288 0,16663836 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,14283288 0,16655882 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,14283288 0,16647935 GO:0006479|protein amino acid methylation, ! spinal cord development GO:0021510 54 26 0,000 0,14283288 0,16639996 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,14283288 0,16632065 ! digestive system process GO:0022600 49 26 0,000 0,14283288 0,16624141 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,14283288 0,16616225 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,14283288 0,16608316 ! neural crest cell development GO:0014032 59 26 0,000 0,14283288 0,16600415 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,14283288 0,16592521 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,14283288 0,16584635 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,14283288 0,16576756 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,14283288 0,16568885 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,14283288 0,16561022 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,14283288 0,16553165 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,14283288 0,16545316 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,14283288 0,16537475 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,14283288 0,16529641 ! telomere organization GO:0032200 46 26 0,000 0,14283288 0,16521815 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,14283288 0,16513995 ! neural tube closure GO:0001843 58 26 0,000 0,14283288 0,16506184 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,14283288 0,16498379 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,14283288 0,16490582 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,14790088 0,17067635 ! embryonic pattern specification GO:0009880 49 27 0,000 0,14790088 0,17059577 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,14790088 0,17051526 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,14790088 0,17043483 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,14790088 0,17035447 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,14790088 0,17027419 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,14790088 0,17019399 ! iron ion transport GO:0006826 65 27 0,000 0,14790088 0,17011386 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,14790088 0,17003381 ! superoxide metabolic process GO:0006801 41 27 0,000 0,14790088 0,16995383 ! tube lumen formation GO:0035148 59 27 0,000 0,14790088 0,16987393 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,14790088 0,1697941 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,14790088 0,16971434 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,14790088 0,16963467 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,14790088 0,16955506 ! neuron fate commitment GO:0048663 52 28 0,000 0,15293905 0,17524864 ! vesicle docking GO:0048278 55 28 0,000 0,15293905 0,17516648 ! circadian rhythm GO:0007623 56 28 0,000 0,15293905 0,17508439 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,15293905 0,17500239 ! sperm motility GO:0030317 37 28 0,000 0,15293905 0,17492046 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,15293905 0,1748386 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,15293905 0,17475683 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,15293905 0,17467513 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,15293905 0,1745935 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,15293905 0,17451196 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,15293905 0,17443048 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,15293905 0,17434909 ! glutathione metabolic process GO:0006749 42 28 0,000 0,15293905 0,17426777 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,15293905 0,17418653 ! lipid oxidation GO:0034440 48 28 0,000 0,15293905 0,17410536 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,15293905 0,17402427 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,15794757 0,17963963 ! translational initiation GO:0006413 66 29 0,000 0,15794757 0,17955604 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,15794757 0,17947252 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,15794757 0,17938909 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,15794757 0,17930573 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,15794757 0,17922245 ! primary neural tube formation GO:0014020 61 29 0,000 0,15794757 0,17913924 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,15794757 0,17905611 ! synaptogenesis GO:0007416 46 29 0,000 0,15794757 0,17897306 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,15794757 0,17889009 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,15794757 0,17880719 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,15794757 0,17872438 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,16292663 0,18427303 ! phenol metabolic process GO:0018958 56 30 0,000 0,16292663 0,18418776 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,16292663 0,18410257 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,16292663 0,18401745 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,16292663 0,18393242 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,16292663 0,18384746 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,16292663 0,18376258 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,16292663 0,18367778 ! acute-phase response GO:0006953 50 30 0,000 0,16292663 0,18359306 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,16292663 0,18350841 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,16292663 0,18342385 ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,16292663 0,18333936 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,16292663 0,18325495 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,16292663 0,18317062 ! cell fate determination GO:0001709 64 30 0,000 0,16292663 0,18308636 ! phospholipid transport GO:0015914 65 30 0,000 0,16292663 0,18300218 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,16292663 0,18291808 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,16292663 0,18283406 ! regulation of coagulation GO:0050818 52 30 0,000 0,16292663 0,18275011 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,16787638 0,18821569 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,16787638 0,18812935 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,16787638 0,18804309 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,16787638 0,18795691 ! regulation of innate immune response GO:0045088 57 31 0,000 0,16787638 0,18787081 ! peptide transport GO:0015833 60 31 0,000 0,16787638 0,18778479 ! detection of light stimulus GO:0009583 44 31 0,000 0,16787638 0,18769885 ! natural killer cell activation GO:0030101 50 31 0,000 0,16787638 0,18761299 ! cofactor catabolic process GO:0051187 54 31 0,000 0,16787638 0,1875272 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,16787638 0,18744149 ! eye morphogenesis GO:0048592 65 31 0,000 0,16787638 0,18735586 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,16787638 0,18727031 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,172797 0,19267141 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,172797 0,19258351 ! collagen metabolic process GO:0032963 49 32 0,000 0,172797 0,1924957 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,172797 0,19240796 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,172797 0,1923203 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,172797 0,19223272 ! mesoderm formation GO:0001707 73 32 0,000 0,172797 0,19214523 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,172797 0,19205781 ! BMP signaling pathway GO:0030509 71 32 0,000 0,172797 0,19197047 ! gene silencing GO:0016458 71 32 0,000 0,172797 0,19188321 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,17768866 0,19722553 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,17768866 0,19713596 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,17768866 0,19704648 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,17768866 0,19695707 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,17768866 0,19686775 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,17768866 0,19677851 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,17768866 0,19668935 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,17768866 0,19660027 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,17768866 0,19651127 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,17768866 0,19642235 ! glial cell differentiation GO:0010001 67 34 0,000 0,18255153 0,20170664 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,18255153 0,20161545 ! cholesterol transport GO:0030301 62 34 0,000 0,18255153 0,20152435 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,18255153 0,20143332 ! spliceosome assembly GO:0000245 75 34 0,000 0,18255153 0,20134238 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,18255153 0,20125152 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,18255153 0,20116075 ! formation of primary germ layer GO:0001704 76 34 0,000 0,18255153 0,20107005 ! cell fate specification GO:0001708 56 34 0,000 0,18255153 0,20097944 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,18255153 0,20088891 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,18255153 0,20079846 ! adult locomotory behavior GO:0008344 62 34 0,000 0,18255153 0,20070809 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,18255153 0,2006178 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,18738577 0,20583788 ! negative regulation of secretion GO:0051048 68 35 0,000 0,18738577 0,20574537 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,18738577 0,20565294 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,18738577 0,2055606 ! membrane docking GO:0022406 69 35 0,000 0,18738577 0,20546833 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,18738577 0,20537615 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,18738577 0,20528406 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,18738577 0,20519204 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,18738577 0,20510011 ! ceramide metabolic process GO:0006672 72 35 0,000 0,18738577 0,20500826 ! telencephalon development GO:0021537 81 35 0,000 0,18738577 0,20491649 ! sterol transport GO:0015918 63 35 0,000 0,18738577 0,20482481 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,18738577 0,20473321 ! vesicle localization GO:0051648 70 35 0,000 0,18738577 0,20464168 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,19219157 0,20979625 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,19219157 0,20970255 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,19219157 0,20960893 ! protein targeting to membrane GO:0006612 75 36 0,000 0,19219157 0,2095154 ! regulation of proteolysis GO:0030162 77 36 0,000 0,19219157 0,20942195 ! aerobic respiration GO:0009060 56 36 0,000 0,19219157 0,20932858 ! cytokine production GO:0001816 68 36 0,000 0,19219157 0,2092353 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,19219157 0,2091421 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,19219157 0,20904898 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,19696908 0,21415018 ! tissue remodeling GO:0048771 78 37 0,000 0,19696908 0,21405492 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,19696908 0,21395974 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,20171847 0,21902143 ! organic anion transport GO:0015711 82 38 0,000 0,20171847 0,21892413 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,20171847 0,21882691 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,20171847 0,21872979 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,20171847 0,21863275 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,20171847 0,21853579 ! spermatid development GO:0007286 69 38 0,000 0,20171847 0,21843892 ! glycogen metabolic process GO:0005977 63 38 0,000 0,20171847 0,21834214 ! neural tube formation GO:0001841 79 38 0,000 0,20171847 0,21824544 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,2064399 0,22325483 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,2064399 0,22315605 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,2064399 0,22305735 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,2064399 0,22295874 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,2064399 0,22286022 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,2064399 0,22276178 ! glucan metabolic process GO:0044042 64 39 0,000 0,2064399 0,22266343 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,21113353 0,22762543 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,21113353 0,22752502 ! learning GO:0007612 82 40 0,000 0,21113353 0,2274247 ! mismatch repair GO:0006298 58 40 0,000 0,21113353 0,22732447 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,21113353 0,22722433 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,21113353 0,22712427 ! RNA export from nucleus GO:0006405 61 41 0,000 0,21579954 0,2320415 ! mRNA catabolic process GO:0006402 79 41 0,000 0,21579954 0,23193941 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,21579954 0,23183742 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,21579954 0,23173551 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,21579954 0,23163369 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,21579954 0,23153196 ! gliogenesis GO:0042063 91 41 0,000 0,21579954 0,23143033 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,21579954 0,23132878 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,21579954 0,23122732 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,21579954 0,23112595 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,21579954 0,23102466 ! RNA modification GO:0009451 64 41 0,000 0,21579954 0,23092347 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,22043808 0,23578382 ! organic ether metabolic process GO:0018904 59 42 0,000 0,22043808 0,23568063 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,22043808 0,23557753 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,22043808 0,23547452 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,22043808 0,23537161 ! regulation of protein secretion GO:0050708 77 42 0,000 0,22043808 0,23526878 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,22043808 0,23516604 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,22043808 0,23506339 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,22504932 0,23987586 ! regulation of tube size GO:0035150 76 43 0,000 0,22504932 0,23977125 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,22504932 0,23966673 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,22504932 0,2395623 ! ion transmembrane transport GO:0034220 79 43 0,000 0,22504932 0,23945796 ! neuron migration GO:0001764 85 43 0,000 0,22504932 0,23935371 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,2296334 0,24412289 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,2296334 0,2440167 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,2296334 0,24391061 ! phagocytosis GO:0006909 105 44 0,000 0,2296334 0,24380461 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,2296334 0,2436987 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,2341905 0,24842701 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,2341905 0,24831918 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,2341905 0,24821145 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,2341905 0,24810381 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,2341905 0,24799627 ! polyol metabolic process GO:0019751 77 45 0,000 0,2341905 0,24788882 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,23872077 0,25257464 ! leukocyte migration GO:0050900 75 46 0,000 0,23872077 0,2524653 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,23872077 0,25235605 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,23872077 0,2522469 ! neural tube development GO:0021915 91 47 0,000 0,24322436 0,25689456 ! positive regulation of defense response GO:0031349 88 48 0,000 0,24770144 0,26151021 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,24770144 0,26139725 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,24770144 0,26128438 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,24770144 0,26117161 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,24770144 0,26105894 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,24770144 0,26094637 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,24770144 0,26083389 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,24770144 0,26072151 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,25215216 0,26529187 ! regulation of ion transport GO:0043269 86 50 0,000 0,25657667 0,26983074 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,25657667 0,26971464 ! endocrine system development GO:0035270 109 50 0,000 0,25657667 0,26959863 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,25657667 0,26948272 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,25657667 0,26936692 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,25657667 0,26925121 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,25657667 0,2691356 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,25657667 0,26902009 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,26097513 0,27351448 ! viral infectious cycle GO:0019058 104 51 0,000 0,26097513 0,27339719 ! peptide metabolic process GO:0006518 80 51 0,000 0,26097513 0,27328 ! Notch signaling pathway GO:0007219 111 52 0,000 0,26534769 0,27773968 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,26534769 0,27762073 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,26534769 0,27750189 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,26534769 0,27738315 ! excretion GO:0007588 87 52 0,000 0,26534769 0,2772645 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,26534769 0,27714596 ! amino acid activation GO:0043038 98 52 0,000 0,26534769 0,27702753 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,2696945 0,28144539 ! inner ear development GO:0048839 89 53 0,000 0,2696945 0,28132522 ! chromatin remodeling GO:0006338 122 53 0,000 0,2696945 0,28120515 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,2696945 0,28108518 ! cartilage development GO:0051216 99 53 0,000 0,2696945 0,28096532 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,27401571 0,28534543 ! neuromuscular process GO:0050905 107 54 0,000 0,27401571 0,28522386 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,27401571 0,28510238 ! membrane fusion GO:0006944 122 54 0,000 0,27401571 0,28498101 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,27401571 0,28485974 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,27401571 0,28473858 ! regulation of cell shape GO:0008360 142 54 0,000 0,27401571 0,28461751 ! RNA catabolic process GO:0006401 103 55 0,000 0,27831148 0,28895663 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,27831148 0,28883388 ! cell recognition GO:0008037 98 55 0,000 0,27831148 0,28871123 ! heart morphogenesis GO:0003007 105 57 0,000 0,28682726 0,29741893 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,29104758 0,30166705 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,29104758 0,30153911 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,29104758 0,30141129 ! gastrulation GO:0007369 122 58 0,000 0,29104758 0,30128357 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,29104758 0,30115596 ! nuclear export GO:0051168 110 59 0,000 0,29524303 0,30536779 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,29941378 0,30955051 ! regulation of endocytosis GO:0030100 104 60 0,000 0,29941378 0,30941957 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,29941378 0,30928874 ! positive regulation of secretion GO:0051047 110 61 0,000 0,30355996 0,31343913 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,30355996 0,31330671 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,30355996 0,3131744 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,30355996 0,31304221 ! regulation of heart contraction GO:0008016 123 61 0,000 0,30355996 0,31291012 ! proton transport GO:0015992 117 61 0,000 0,30355996 0,31277815 ! viral reproductive process GO:0022415 132 62 0,000 0,30768172 0,31689142 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,30768172 0,31675788 ! tRNA processing GO:0008033 102 62 0,000 0,30768172 0,31662445 ! mesoderm development GO:0007498 128 63 0,000 0,3117792 0,32070593 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,3117792 0,32057096 ! hydrogen transport GO:0006818 121 64 0,000 0,31585255 0,32462254 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,31585255 0,32448603 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,3199019 0,32850792 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,3199019 0,32836989 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,3199019 0,32823198 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,3239274 0,33222277 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,32792918 0,33618589 GO:0035113|embryonic appendage morphogenesis, ! viral reproduction GO:0016032 142 68 0,000 0,33190739 0,34012154 ! adaptive immune response GO:0002250 126 68 0,000 0,33190739 0,33997893 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,33586216 0,34388569 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,33586216 0,34374162 ! single fertilization GO:0007338 83 69 0,000 0,33586216 0,34359768 ! cell redox homeostasis GO:0045454 114 70 0,000 0,33979363 0,34747419 ! activation of immune response GO:0002253 120 70 0,000 0,33979363 0,3473288 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,33979363 0,34718354 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,34370194 0,35103003 ! appendage morphogenesis GO:0035107 150 72 0,000 0,34758722 0,3548498 GO:0035108|limb morphogenesis, ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,34758722 0,35470158 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,34758722 0,35455348 ! appendage development GO:0048736 151 73 0,000 0,35144961 0,35834365 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,35144961 0,35819416 ! regulation of immune effector process GO:0002697 156 73 0,000 0,35144961 0,35804479 ! acute inflammatory response GO:0002526 118 74 0,000 0,35528924 0,36180559 ! amino acid transport GO:0006865 148 74 0,000 0,35528924 0,36165484 ! transition metal ion transport GO:0000041 143 75 0,000 0,35910625 0,36538799 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,35910625 0,36523587 ! learning or memory GO:0007611 161 76 0,000 0,36290076 0,36894156 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,36290076 0,36878809 ! amine catabolic process GO:0009310 136 77 0,000 0,36667292 0,37246651 ! neurotransmitter transport GO:0006836 142 77 0,000 0,36667292 0,3723117 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,36667292 0,37215702 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,36667292 0,37200247 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,37042285 0,3756509 ! antigen processing and presentation GO:0019882 117 78 0,000 0,37042285 0,37549503 ! fertilization GO:0009566 99 78 0,000 0,37042285 0,37533929 ! blood coagulation GO:0007596 151 79 0,000 0,37415068 0,37895941 GO:0050817|coagulation, ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,37415068 0,37880236 ! exocytosis GO:0006887 153 83 0,000 0,38884359 0,39351487 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,38884359 0,39335193 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,38884359 0,39318912 ! digestion GO:0007586 130 84 0,000 0,39246286 0,39668464 ! hemostasis GO:0007599 165 85 0,000 0,3960608 0,40015572 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,3960608 0,3999903 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,40319317 0,40702517 ! nucleosome assembly GO:0006334 126 87 0,000 0,40319317 0,40685705 ! cellular respiration GO:0045333 143 88 0,000 0,40672786 0,4102544 ! amine biosynthetic process GO:0009309 146 88 0,000 0,40672786 0,41008509 ! sensory perception of smell GO:0007608 117 88 0,000 0,40672786 0,40991591 ! chromatin assembly GO:0031497 128 88 0,000 0,40672786 0,40974687 ! cellular defense response GO:0006968 123 89 0,000 0,41024171 0,41311645 ! regulation of neurological system process GO:0031644 175 89 0,000 0,41024171 0,41294623 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,41373485 0,41629088 ! defense response to bacterium GO:0042742 112 91 0,000 0,4172074 0,41961205 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,42065948 0,42290992 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,4240912 0,42618462 ! amine transport GO:0015837 181 93 0,000 0,4240912 0,42600938 ! vitamin metabolic process GO:0006766 153 93 0,000 0,4240912 0,42583428 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,42750269 0,42908344 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,42750269 0,42890722 ! regulation of defense response GO:0031347 171 95 0,000 0,43089407 0,43213228 ! nucleosome organization GO:0034728 143 95 0,000 0,43089407 0,43195495 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,43089407 0,43177778 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,43089407 0,43160075 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,43089407 0,43142386 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,43761697 0,43797552 ! mRNA transport GO:0051028 185 100 0,000 0,44755339 0,44773666 ! positive regulation of immune response GO:0050778 175 100 0,000 0,44755339 0,44755339