pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6423-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of positive chemotaxis GO:0050930 14 8 3,000 4,733E-08 1,089E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 5,604E-08 6,445E-05 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 8,79E-08 6,739E-05 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 2,205E-07 1,268E-04 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of cell migration GO:0030335 92 51 5,000 2,511E-07 1,155E-04 ! cell junction assembly GO:0034329 56 28 4,000 3,058E-07 1,172E-04 ! positive regulation of cell motion GO:0051272 99 56 5,000 4,434E-07 1,457E-04 ! peptidyl-amino acid modification GO:0018193 147 93 6,000 5,397E-07 1,552E-04 ! cell junction organization GO:0034330 63 33 4,000 7,235E-07 1,849E-04 ! neutrophil chemotaxis GO:0030593 21 16 3,000 1,192E-06 2,741E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 1,354E-06 2,832E-04 ! negative regulation of survival gene product expression GO:0008634 6 5 2,000 1,354E-06 2,596E-04 ! cell-substrate junction assembly GO:0007044 39 17 3,000 1,552E-06 2,747E-04 ! response to hypoxia GO:0001666 132 72 5,000 1,996E-06 3,279E-04 ! response to oxygen levels GO:0070482 137 74 5,000 2,347E-06 3,599E-04 ! positive regulation of locomotion GO:0040017 35 20 3,000 3,123E-06 4,489E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 3,000 3,842E-06 5,198E-04 ! response to UV GO:0009411 75 46 4,000 3,962E-06 5,062E-04 ! protein import into nucleus, translocation GO:0000060 36 22 3,000 4,677E-06 5,662E-04 ! regulation of behavior GO:0050795 38 22 3,000 4,677E-06 5,379E-04 ! T-helper 1 type immune response GO:0042088 11 7 2,000 4,704E-06 5,152E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 4,704E-06 4,918E-04 ! regulation of membrane potential GO:0042391 128 85 5,000 5,293E-06 5,293E-04 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 5,64E-06 5,405E-04 ! interphase of mitotic cell cycle GO:0051329 156 86 5,000 5,667E-06 5,213E-04 ! interphase GO:0051325 159 88 5,000 6,477E-06 5,73E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 6,741E-06 5,742E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 7,498E-06 6,159E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 7,993E-06 6,339E-04 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of bone remodeling GO:0046850 90 53 4,000 8,059E-06 6,179E-04 ! regulation of tissue remodeling GO:0034103 91 54 4,000 8,845E-06 6,563E-04 ! response to light stimulus GO:0009416 153 96 5,000 1,072E-05 7,703E-04 ! SMAD protein nuclear translocation GO:0007184 15 9 2,000 1,12E-05 7,809E-04 ! alpha-beta T cell differentiation GO:0046632 14 9 2,000 1,12E-05 7,58E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 1,12E-05 7,363E-04 ! spleen development GO:0048536 15 9 2,000 1,12E-05 7,159E-04 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 1,157E-05 7,191E-04 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 1,157E-05 7,002E-04 ! negative regulation of kinase activity GO:0033673 100 58 4,000 1,261E-05 7,435E-04 ! hair follicle morphogenesis GO:0031069 17 10 2,000 1,595E-05 9,169E-04 ! peptide or protein amino-terminal blocking GO:0018409 14 10 2,000 1,595E-05 8,946E-04 ! alpha-beta T cell activation GO:0046631 16 10 2,000 1,595E-05 8,733E-04 ! negative regulation of transferase activity GO:0051348 105 61 4,000 1,617E-05 8,649E-04 ! leukocyte chemotaxis GO:0030595 43 31 3,000 1,941E-05 1,015E-03 GO:0060326|cell chemotaxis, ! focal adhesion formation GO:0048041 24 11 2,000 2,184E-05 1,116E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 2,184E-05 1,092E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 2,184E-05 1,069E-03 GO:0010829|negative regulation of glucose transport, ! positive regulation of cell development GO:0010720 54 33 3,000 2,504E-05 1,2E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 2,827E-05 1,327E-03 ! gland morphogenesis GO:0022612 23 12 2,000 2,902E-05 1,335E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 2,000 3,758E-05 1,695E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 3,758E-05 1,662E-03 ! pigmentation GO:0043473 74 38 3,000 4,429E-05 1,922E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 4,765E-05 2,029E-03 ! epidermis morphogenesis GO:0048730 29 14 2,000 4,765E-05 1,992E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 4,765E-05 1,957E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 4,915E-05 1,983E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 5,44E-05 2,157E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 5,933E-05 2,313E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 5,933E-05 2,274E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 5,933E-05 2,237E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 5,933E-05 2,201E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 5,933E-05 2,166E-03 ! dopamine metabolic process GO:0042417 30 15 2,000 5,933E-05 2,132E-03 ! defense response to virus GO:0051607 27 15 2,000 5,933E-05 2,099E-03 ! regulation of cell adhesion GO:0030155 159 83 4,000 7,212E-05 2,513E-03 ! leukocyte migration GO:0050900 60 43 3,000 7,259E-05 2,492E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 7,259E-05 2,455E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 8,082E-05 2,694E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 8,694E-05 2,857E-03 ! memory GO:0007613 25 17 2,000 8,801E-05 2,851E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 8,801E-05 2,811E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 8,801E-05 2,773E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 8,801E-05 2,735E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 8,801E-05 2,699E-03 ! regulation of ossification GO:0030278 71 46 3,000 9,485E-05 2,87E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 1,052E-04 3,143E-03 ! regulation of glucose import GO:0046324 21 18 2,000 1,052E-04 3,102E-03 GO:0010827|regulation of glucose transport, ! response to alkaloid GO:0043279 32 19 2,000 1,245E-04 3,624E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,245E-04 3,578E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 1,245E-04 3,534E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 1,245E-04 3,491E-03 ! positive regulation of growth GO:0045927 67 50 3,000 1,317E-04 3,651E-03 ! regulation of binding GO:0051098 151 95 4,000 1,37E-04 3,752E-03 ! response to ethanol GO:0045471 37 20 2,000 1,459E-04 3,947E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,459E-04 3,901E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 1,459E-04 3,857E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 1,696E-04 4,431E-03 ! protein amino acid acylation GO:0043543 37 21 2,000 1,696E-04 4,382E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 1,696E-04 4,333E-03 ! molting cycle process GO:0022404 40 22 2,000 1,956E-04 4,943E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! vasculogenesis GO:0001570 33 22 2,000 1,956E-04 4,89E-03 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 2,052E-04 5,074E-03 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 2,052E-04 5,02E-03 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 2,241E-04 5,425E-03 ! myelination GO:0042552 35 23 2,000 2,241E-04 5,369E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 2,241E-04 5,313E-03 ! actin filament organization GO:0007015 95 59 3,000 2,512E-04 5,896E-03 ! mitochondrial membrane organization GO:0007006 39 24 2,000 2,551E-04 5,927E-03 ! sleep GO:0030431 11 5 1,000 2,653E-04 6,101E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,653E-04 6,041E-03 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 2,653E-04 5,982E-03 ! embryonic hemopoiesis GO:0035162 10 5 1,000 2,653E-04 5,924E-03 ! response to protozoan GO:0001562 9 5 1,000 2,653E-04 5,867E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 2,653E-04 5,811E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 2,653E-04 5,756E-03 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 2,653E-04 5,702E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 2,653E-04 5,649E-03 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 2,653E-04 5,598E-03 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 6 5 1,000 2,653E-04 5,547E-03 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 1,000 2,653E-04 5,497E-03 ! muscle cell proliferation GO:0033002 8 5 1,000 2,653E-04 5,448E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,653E-04 5,399E-03 ! regulation of hair follicle development GO:0051797 9 5 1,000 2,653E-04 5,352E-03 GO:0042634|regulation of hair cycle, ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 2,653E-04 5,306E-03 ! glial cell migration GO:0008347 10 5 1,000 2,653E-04 5,26E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 2,653E-04 5,215E-03 ! lymphocyte activation during immune response GO:0002285 9 5 1,000 2,653E-04 5,171E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 2,653E-04 5,127E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 2,653E-04 5,084E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 2,653E-04 5,042E-03 ! regulation of heart contraction GO:0008016 91 60 3,000 2,681E-04 5,055E-03 ! regulation of homeostatic process GO:0032844 105 60 3,000 2,681E-04 5,014E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 2,888E-04 5,357E-03 ! negative regulation of cell growth GO:0030308 106 62 3,000 3,043E-04 5,599E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 3,236E-04 5,908E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 3,253E-04 5,891E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 3,253E-04 5,845E-03 ! negative regulation of cell size GO:0045792 108 64 3,000 3,439E-04 6,131E-03 ! catechol metabolic process GO:0009712 43 27 2,000 3,646E-04 6,45E-03 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 1,000 3,966E-04 6,963E-03 ! male meiosis GO:0007140 7 6 1,000 3,966E-04 6,91E-03 ! meiotic prophase I GO:0007128 9 6 1,000 3,966E-04 6,858E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 3,966E-04 6,807E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 3,966E-04 6,756E-03 ! mRNA stabilization GO:0048255 15 6 1,000 3,966E-04 6,707E-03 GO:0043489|RNA stabilization, ! activation of MAPKKK activity GO:0000185 10 6 1,000 3,966E-04 6,658E-03 ! protein lipoylation GO:0009249 10 6 1,000 3,966E-04 6,609E-03 ! pigment granule organization GO:0048753 11 6 1,000 3,966E-04 6,562E-03 ! ER overload response GO:0006983 7 6 1,000 3,966E-04 6,515E-03 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 3,966E-04 6,469E-03 ! maintenance of protein location in nucleus GO:0051457 16 6 1,000 3,966E-04 6,423E-03 ! neuron apoptosis GO:0051402 8 6 1,000 3,966E-04 6,378E-03 ! male sex determination GO:0030238 9 6 1,000 3,966E-04 6,334E-03 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 3,966E-04 6,29E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 3,966E-04 6,247E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 3,966E-04 6,205E-03 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 1,000 3,966E-04 6,163E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 3,966E-04 6,121E-03 ! phenol metabolic process GO:0018958 44 28 2,000 4,068E-04 6,237E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 4,068E-04 6,196E-03 ! ensheathment of neurons GO:0007272 43 28 2,000 4,068E-04 6,155E-03 GO:0008366|axon ensheathment, ! regulation of neuron differentiation GO:0045664 107 67 3,000 4,099E-04 6,162E-03 ! activation of protein kinase activity GO:0032147 102 69 3,000 4,587E-04 6,85E-03 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 4,846E-04 7,19E-03 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 4,846E-04 7,144E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 5,394E-04 7,902E-03 GO:0045937|positive regulation of phosphate metabolic process, ! DNA damage checkpoint GO:0000077 53 31 2,000 5,519E-04 8,033E-03 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 5,519E-04 7,983E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 5,533E-04 7,954E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 5,533E-04 7,904E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 5,533E-04 7,856E-03 ! microtubule bundle formation GO:0001578 8 7 1,000 5,533E-04 7,807E-03 ! protein-cofactor linkage GO:0018065 13 7 1,000 5,533E-04 7,76E-03 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 1,000 5,533E-04 7,713E-03 ! regulation of pigmentation during development GO:0048070 15 7 1,000 5,533E-04 7,666E-03 ! organ growth GO:0035265 11 7 1,000 5,533E-04 7,62E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 5,533E-04 7,575E-03 ! behavioral fear response GO:0001662 13 7 1,000 5,533E-04 7,53E-03 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 5,533E-04 7,486E-03 ! response to UV-B GO:0010224 11 7 1,000 5,533E-04 7,442E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 5,533E-04 7,399E-03 ! regulation of interleukin-10 production GO:0032653 11 7 1,000 5,533E-04 7,356E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 5,533E-04 7,314E-03 ! neuroblast proliferation GO:0007405 13 7 1,000 5,533E-04 7,272E-03 ! peptidyl-threonine modification GO:0018210 18 7 1,000 5,533E-04 7,231E-03 ! positive regulation of epidermis development GO:0045684 11 7 1,000 5,533E-04 7,19E-03 ! dopamine biosynthetic process GO:0042416 15 7 1,000 5,533E-04 7,15E-03 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 5,533E-04 7,11E-03 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 1,000 5,533E-04 7,07E-03 ! tube morphogenesis GO:0035239 118 73 3,000 5,684E-04 7,223E-03 ! mitochondrion organization GO:0007005 104 73 3,000 5,684E-04 7,183E-03 ! protein import into nucleus GO:0006606 118 74 3,000 5,985E-04 7,523E-03 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 5,985E-04 7,482E-03 ! regulation of muscle development GO:0048634 48 32 2,000 6,067E-04 7,542E-03 ! negative regulation of growth GO:0045926 123 75 3,000 6,298E-04 7,787E-03 ! nuclear import GO:0051170 121 75 3,000 6,298E-04 7,746E-03 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 6,621E-04 8,1E-03 ! nucleus organization GO:0006997 49 33 2,000 6,648E-04 8,091E-03 ! regulation of DNA binding GO:0051101 119 77 3,000 6,956E-04 8,421E-03 ! gland development GO:0048732 148 77 3,000 6,956E-04 8,377E-03 ! DNA integrity checkpoint GO:0031570 57 34 2,000 7,264E-04 8,702E-03 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 2,000 7,264E-04 8,657E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 7,352E-04 8,717E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 7,352E-04 8,672E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 7,352E-04 8,628E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 7,352E-04 8,584E-03 ! middle ear morphogenesis GO:0042474 9 8 1,000 7,352E-04 8,541E-03 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 7,352E-04 8,498E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 7,352E-04 8,455E-03 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 1,000 7,352E-04 8,413E-03 ! melanin metabolic process GO:0006582 12 8 1,000 7,352E-04 8,372E-03 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 7,352E-04 8,33E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 7,352E-04 8,29E-03 ! regulation of gliogenesis GO:0014013 20 8 1,000 7,352E-04 8,249E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 7,352E-04 8,209E-03 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 7,352E-04 8,169E-03 ! leukocyte activation during immune response GO:0002366 13 8 1,000 7,352E-04 8,13E-03 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 1,000 7,352E-04 8,091E-03 ! prophase GO:0051324 11 8 1,000 7,352E-04 8,053E-03 ! regulation of telomere maintenance GO:0032204 10 8 1,000 7,352E-04 8,015E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 7,352E-04 7,977E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 7,352E-04 7,939E-03 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 7,916E-04 8,507E-03 ! regulation of action potential in neuron GO:0019228 54 35 2,000 7,916E-04 8,468E-03 ! protein localization in nucleus GO:0034504 133 80 3,000 8,034E-04 8,555E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 9,421E-04 9,986E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 9,421E-04 9,94E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 9,421E-04 9,894E-03 ! lung alveolus development GO:0048286 17 9 1,000 9,421E-04 9,849E-03 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 9,421E-04 9,805E-03 ! T cell selection GO:0045058 18 9 1,000 9,421E-04 9,761E-03 ! indolalkylamine metabolic process GO:0006586 14 9 1,000 9,421E-04 9,717E-03 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! motor axon guidance GO:0008045 14 9 1,000 9,421E-04 9,674E-03 ! response to amine stimulus GO:0014075 13 9 1,000 9,421E-04 9,631E-03 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! oocyte differentiation GO:0009994 12 9 1,000 9,421E-04 9,588E-03 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 9,421E-04 9,546E-03 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 9,421E-04 9,504E-03 ! response to nicotine GO:0035094 16 9 1,000 9,421E-04 9,462E-03 ! localization within membrane GO:0051668 15 9 1,000 9,421E-04 9,421E-03 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 1,008E-03 0,01004081 ! regulation of protein localization GO:0032880 132 85 3,000 1,008E-03 9,998E-03 ! mesenchymal cell development GO:0014031 64 38 2,000 1,009E-03 9,958E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! cell cycle arrest GO:0007050 150 86 3,000 1,053E-03 0,01035463 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 1,1E-03 0,01076487 ! T cell differentiation GO:0030217 65 40 2,000 1,173E-03 0,01142846 ! B cell differentiation GO:0030183 62 40 2,000 1,173E-03 0,01138024 ! negative regulation of muscle development GO:0048635 12 10 1,000 1,174E-03 0,01134208 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,174E-03 0,01129462 ! regulation of phosphatase activity GO:0010921 21 10 1,000 1,174E-03 0,01124756 ! hippocampus development GO:0021766 19 10 1,000 1,174E-03 0,01120089 ! blood vessel remodeling GO:0001974 21 10 1,000 1,174E-03 0,0111546 ! positive regulation of heart contraction GO:0045823 14 10 1,000 1,174E-03 0,0111087 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,174E-03 0,01106317 ! B cell proliferation GO:0042100 14 10 1,000 1,174E-03 0,01101802 ! fear response GO:0042596 16 10 1,000 1,174E-03 0,01097323 ! negative regulation of ossification GO:0030279 19 10 1,000 1,174E-03 0,0109288 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,174E-03 0,01088473 ! regulation of bone resorption GO:0045124 24 10 1,000 1,174E-03 0,01084102 ! salivary gland development GO:0007431 22 10 1,000 1,174E-03 0,01079766 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,174E-03 0,01075464 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,174E-03 0,01071196 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of neurogenesis GO:0050767 153 89 3,000 1,197E-03 0,01088182 ! leukocyte differentiation GO:0002521 143 90 3,000 1,248E-03 0,01129843 ! regulation of T cell differentiation GO:0045580 59 41 2,000 1,26E-03 0,0113692 ! response to virus GO:0009615 122 91 3,000 1,3E-03 0,01167939 ! mitochondrial transport GO:0006839 60 42 2,000 1,352E-03 0,01210297 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 1,352E-03 0,01205606 ! cellular component disassembly GO:0022411 64 42 2,000 1,352E-03 0,01200951 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 1,352E-03 0,01196332 ! virus-host interaction GO:0019048 17 11 1,000 1,43E-03 0,01259816 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,43E-03 0,01255007 ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,43E-03 0,01250235 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 1,43E-03 0,012455 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 1,43E-03 0,012408 ! regulation of interleukin-8 production GO:0032677 17 11 1,000 1,43E-03 0,01236135 ! T cell homeostasis GO:0043029 20 11 1,000 1,43E-03 0,01231505 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,43E-03 0,0122691 ! digestive tract morphogenesis GO:0048546 15 11 1,000 1,43E-03 0,01222349 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 1,43E-03 0,01217822 GO:0042130|negative regulation of T cell proliferation, ! epithelial tube morphogenesis GO:0060562 65 43 2,000 1,448E-03 0,01229235 ! angiogenesis GO:0001525 149 95 3,000 1,524E-03 0,01288853 ! regulation of action potential GO:0001508 71 44 2,000 1,549E-03 0,01304612 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 1,549E-03 0,0129985 ! regulation of inflammatory response GO:0050727 60 44 2,000 1,549E-03 0,01295123 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 1,549E-03 0,01290431 ! regulation of response to external stimulus GO:0032101 139 96 3,000 1,584E-03 0,01315416 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,653E-03 0,0136752 ! positive regulation of defense response GO:0031349 59 45 2,000 1,653E-03 0,01362618 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,71E-03 0,01404427 ! palate development GO:0060021 15 12 1,000 1,71E-03 0,01399429 ! positive regulation of cell growth GO:0030307 16 12 1,000 1,71E-03 0,01394467 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 1,71E-03 0,01389539 ! cell-cell junction assembly GO:0007043 18 12 1,000 1,71E-03 0,01384647 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,71E-03 0,01379788 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,71E-03 0,01374964 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,71E-03 0,01370173 ! response to gamma radiation GO:0010332 20 12 1,000 1,71E-03 0,01365415 ! regulation of epidermis development GO:0045682 17 12 1,000 1,71E-03 0,01360691 ! regulation of mRNA stability GO:0043488 27 12 1,000 1,71E-03 0,01355999 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 1,71E-03 0,01351339 ! extracellular structure organization GO:0043062 156 99 3,000 1,774E-03 0,01397403 ! protein import GO:0017038 156 99 3,000 1,774E-03 0,01392634 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 1,774E-03 0,01387897 ! protein localization in organelle GO:0033365 161 100 3,000 1,841E-03 0,01435157 ! negative regulation of immune system process GO:0002683 73 47 2,000 1,875E-03 0,01456683 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 1,875E-03 0,01451778 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 1,875E-03 0,01446907 ! regulation of muscle contraction GO:0006937 69 48 2,000 1,992E-03 0,01532451 ! heart morphogenesis GO:0003007 65 48 2,000 1,992E-03 0,01527343 ! regulation of DNA replication GO:0006275 75 48 2,000 1,992E-03 0,01522269 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 1,992E-03 0,01517228 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 1,000 2,014E-03 0,01528602 ! exocrine system development GO:0035272 27 13 1,000 2,014E-03 0,01523573 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 2,014E-03 0,01518578 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 2,014E-03 0,01513615 ! cellular pigmentation GO:0033059 24 13 1,000 2,014E-03 0,01508685 ! regulation of RNA stability GO:0043487 28 13 1,000 2,014E-03 0,01503787 ! lymphocyte homeostasis GO:0002260 24 13 1,000 2,014E-03 0,0149892 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 1,000 2,014E-03 0,01494085 ! regulation of intracellular transport GO:0032386 78 49 2,000 2,114E-03 0,01563538 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 2,114E-03 0,01558527 ! cartilage development GO:0051216 70 49 2,000 2,114E-03 0,01553548 ! ear development GO:0043583 72 50 2,000 2,241E-03 0,01641287 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 2,341E-03 0,01709633 ! neuron maturation GO:0042551 21 14 1,000 2,341E-03 0,01704222 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,341E-03 0,01698846 ! heterophilic cell adhesion GO:0007157 29 14 1,000 2,341E-03 0,01693504 ! limbic system development GO:0021761 25 14 1,000 2,341E-03 0,01688195 ! startle response GO:0001964 21 14 1,000 2,341E-03 0,0168292 ! activation of MAPKK activity GO:0000186 21 14 1,000 2,341E-03 0,01677677 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 2,341E-03 0,01672467 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 2,341E-03 0,01667289 GO:0060675|ureteric bud morphogenesis, ! positive regulation of axonogenesis GO:0050772 19 14 1,000 2,341E-03 0,01662143 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 2,341E-03 0,01657029 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 2,341E-03 0,01651946 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 2,341E-03 0,01646894 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 2,372E-03 0,01663194 ! skeletal system morphogenesis GO:0048705 78 53 2,000 2,648E-03 0,01851322 ! positive regulation of cell size GO:0045793 20 15 1,000 2,693E-03 0,01876625 ! metencephalon development GO:0022037 19 15 1,000 2,693E-03 0,01870955 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 2,693E-03 0,0186532 ! lipid phosphorylation GO:0046834 23 15 1,000 2,693E-03 0,01859718 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 1,000 2,693E-03 0,0185415 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 2,693E-03 0,01848616 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 2,693E-03 0,01843114 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 2,693E-03 0,01837645 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 2,693E-03 0,01832208 ! DNA catabolic process GO:0006308 67 54 2,000 2,793E-03 0,01895293 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 3,067E-03 0,02074604 ! protein amino acid acetylation GO:0006473 28 16 1,000 3,067E-03 0,0206852 ! patterning of blood vessels GO:0001569 24 16 1,000 3,067E-03 0,02062472 ! regulation of protein binding GO:0043393 27 16 1,000 3,067E-03 0,02056459 ! regulation of dephosphorylation GO:0035303 33 16 1,000 3,067E-03 0,02050481 ! negative regulation of immune response GO:0050777 28 16 1,000 3,067E-03 0,02044537 ! oogenesis GO:0048477 23 16 1,000 3,067E-03 0,02038628 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 3,067E-03 0,02032753 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 3,067E-03 0,02026912 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 3,464E-03 0,02282852 ! forelimb morphogenesis GO:0035136 19 17 1,000 3,464E-03 0,02276329 ! regulation of viral genome replication GO:0045069 24 17 1,000 3,464E-03 0,02269844 ! actin filament bundle formation GO:0051017 26 17 1,000 3,464E-03 0,02263396 ! neuromuscular junction development GO:0007528 23 17 1,000 3,464E-03 0,02256984 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 3,464E-03 0,02250608 ! cell-cell junction organization GO:0045216 25 17 1,000 3,464E-03 0,02244268 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 3,593E-03 0,02321595 ! lung development GO:0030324 94 59 2,000 3,593E-03 0,02315092 ! positive regulation of DNA replication GO:0045740 29 18 1,000 3,884E-03 0,02495195 ! positive regulation of translation GO:0045727 28 18 1,000 3,884E-03 0,02488245 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 1,000 3,884E-03 0,02481333 ! pigmentation during development GO:0048066 31 18 1,000 3,884E-03 0,02474459 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 3,884E-03 0,02467624 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 3,884E-03 0,02460826 ! visual learning GO:0008542 35 18 1,000 3,884E-03 0,02454066 ! somitogenesis GO:0001756 24 18 1,000 3,884E-03 0,02447342 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 3,884E-03 0,02440655 ! gut development GO:0048565 26 18 1,000 3,884E-03 0,02434005 ! negative regulation of T cell activation GO:0050868 25 18 1,000 3,884E-03 0,02427391 ! meiosis GO:0007126 96 61 2,000 3,949E-03 0,02461173 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 3,949E-03 0,02454521 ! extracellular matrix organization GO:0030198 103 61 2,000 3,949E-03 0,02447905 ! respiratory tube development GO:0030323 99 62 2,000 4,134E-03 0,02555894 ! meiotic cell cycle GO:0051321 97 62 2,000 4,134E-03 0,02549041 ! regulation of transcription factor activity GO:0051090 97 63 2,000 4,324E-03 0,02659385 GO:0090046|regulation of transcription regulator activity, ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 4,326E-03 0,02653343 ! positive regulation of ossification GO:0045778 30 19 1,000 4,326E-03 0,02646286 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 4,326E-03 0,02639267 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 1,000 4,326E-03 0,02632285 ! regeneration GO:0031099 32 19 1,000 4,326E-03 0,0262534 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 4,326E-03 0,02618431 ! sex determination GO:0007530 29 19 1,000 4,326E-03 0,02611558 ! plasma membrane fusion GO:0045026 23 19 1,000 4,326E-03 0,02604722 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 4,326E-03 0,02597921 ! renal system process GO:0003014 35 19 1,000 4,326E-03 0,02591155 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 4,326E-03 0,02584425 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 4,326E-03 0,0257773 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 4,326E-03 0,02571069 ! cell cycle checkpoint GO:0000075 108 64 2,000 4,52E-03 0,02679474 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 4,52E-03 0,02672586 ! respiratory system development GO:0060541 100 64 2,000 4,52E-03 0,02665733 ! adaptive immune response GO:0002250 94 64 2,000 4,52E-03 0,02658915 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 2,000 4,721E-03 0,027701 ! hindlimb morphogenesis GO:0035137 32 20 1,000 4,791E-03 0,02803643 ! multicellular organismal response to stress GO:0033555 32 20 1,000 4,791E-03 0,02796527 ! pallium development GO:0021543 38 20 1,000 4,791E-03 0,02789447 ! collagen fibril organization GO:0030199 45 20 1,000 4,791E-03 0,02782403 ! positive regulation of B cell activation GO:0050871 31 20 1,000 4,791E-03 0,02775394 ! cell-substrate adhesion GO:0031589 121 66 2,000 4,928E-03 0,02847612 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 5,277E-03 0,03041877 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 5,277E-03 0,03034272 ! positive regulation of bone remodeling GO:0046852 33 21 1,000 5,277E-03 0,03026705 GO:0034105|positive regulation of tissue remodeling, ! dendrite development GO:0016358 35 21 1,000 5,277E-03 0,03019176 ! visual behavior GO:0007632 39 21 1,000 5,277E-03 0,03011685 ! ovarian follicle development GO:0001541 30 21 1,000 5,277E-03 0,0300423 ! cell aging GO:0007569 32 21 1,000 5,277E-03 0,02996812 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 5,277E-03 0,02989431 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 5,277E-03 0,02982086 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 5,277E-03 0,02974777 ! platelet activation GO:0030168 28 21 1,000 5,277E-03 0,02967503 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 5,277E-03 0,02960266 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 5,277E-03 0,02953063 ! response to cytokine stimulus GO:0034097 47 21 1,000 5,277E-03 0,02945895 ! learning or memory GO:0007611 123 68 2,000 5,357E-03 0,02983069 ! response to drug GO:0042493 108 69 2,000 5,579E-03 0,03099547 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 5,785E-03 0,0320622 ! leukocyte adhesion GO:0007159 38 22 1,000 5,785E-03 0,03198513 ! glutamate signaling pathway GO:0007215 34 22 1,000 5,785E-03 0,03190842 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 5,785E-03 0,03183209 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 5,785E-03 0,03175612 ! ureteric bud development GO:0001657 32 22 1,000 5,785E-03 0,03168051 ! regulation of tumor necrosis factor production GO:0032680 28 22 1,000 5,785E-03 0,03160526 ! membrane depolarization GO:0051899 35 22 1,000 5,785E-03 0,03153036 ! leukocyte homeostasis GO:0001776 33 22 1,000 5,785E-03 0,03145582 ! neural tube closure GO:0001843 33 22 1,000 5,785E-03 0,03138163 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! protein tetramerization GO:0051262 39 22 1,000 5,785E-03 0,0313078 ! humoral immune response GO:0006959 86 70 2,000 5,807E-03 0,03135398 ! regulation of catabolic process GO:0009894 106 70 2,000 5,807E-03 0,03128055 ! lymphocyte differentiation GO:0030098 113 71 2,000 6,041E-03 0,03246301 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 6,315E-03 0,03385536 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 6,315E-03 0,03377663 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 6,315E-03 0,03369826 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 6,315E-03 0,03362025 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 6,315E-03 0,03354261 ! regulation of viral reproduction GO:0050792 32 23 1,000 6,315E-03 0,03346532 ! interaction with host GO:0051701 37 23 1,000 6,315E-03 0,03338839 ! lymphocyte proliferation GO:0046651 36 23 1,000 6,315E-03 0,03331181 ! negative regulation of catabolic process GO:0009895 34 23 1,000 6,315E-03 0,03323558 ! negative regulation of transport GO:0051051 116 73 2,000 6,525E-03 0,03426332 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 6,775E-03 0,03549721 ! positive regulation of cell projection organization GO:0031346 39 24 1,000 6,866E-03 0,03588855 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 6,866E-03 0,03580717 ! regulation of interferon-gamma production GO:0032649 30 24 1,000 6,866E-03 0,03572616 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 6,866E-03 0,03564552 ! response to toxin GO:0009636 38 24 1,000 6,866E-03 0,03556523 ! primary neural tube formation GO:0014020 35 24 1,000 6,866E-03 0,03548531 ! negative regulation of cell development GO:0010721 56 24 1,000 6,866E-03 0,03540575 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 6,866E-03 0,03532654 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 6,866E-03 0,03524769 ! glutathione metabolic process GO:0006749 29 24 1,000 6,866E-03 0,03516919 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 6,866E-03 0,03509103 ! regulation of protein transport GO:0051223 114 76 2,000 7,293E-03 0,03719347 GO:0070201|regulation of establishment of protein localization, ! male gonad development GO:0008584 33 25 1,000 7,438E-03 0,03784585 ! iron ion homeostasis GO:0055072 39 25 1,000 7,438E-03 0,03776231 ! regulation of chromosome organization GO:0033044 35 25 1,000 7,438E-03 0,03767913 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 7,438E-03 0,03759632 ! leukocyte proliferation GO:0070661 39 25 1,000 7,438E-03 0,03751387 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 7,438E-03 0,03743179 ! positive regulation of protein modification process GO:0031401 107 78 2,000 7,834E-03 0,0393402 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 8,03E-03 0,04023858 ! post-embryonic development GO:0009791 42 26 1,000 8,03E-03 0,04015111 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 8,03E-03 0,04006401 ! T cell activation GO:0042110 134 79 2,000 8,113E-03 0,04038847 ! acute-phase response GO:0006953 42 27 1,000 8,643E-03 0,04293735 ! response to ionizing radiation GO:0010212 47 27 1,000 8,643E-03 0,04284481 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 8,643E-03 0,04275267 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 8,643E-03 0,04266093 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 8,643E-03 0,04256958 ! positive regulation of cell activation GO:0050867 120 81 2,000 8,688E-03 0,04269843 GO:0002696|positive regulation of leukocyte activation, ! response to organic cyclic substance GO:0014070 47 28 1,000 9,277E-03 0,04549521 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 9,277E-03 0,04539842 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 9,277E-03 0,04530203 ! myeloid leukocyte activation GO:0002274 39 28 1,000 9,277E-03 0,04520605 ! neural tube formation GO:0001841 41 28 1,000 9,277E-03 0,04511048 ! positive regulation of catabolic process GO:0009896 40 28 1,000 9,277E-03 0,04501531 ! regulation of B cell activation GO:0050864 42 28 1,000 9,277E-03 0,04492054 ! biogenic amine metabolic process GO:0006576 121 83 2,000 9,287E-03 0,04487411 ! regulation of defense response GO:0031347 117 84 2,000 9,595E-03 0,04626626 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 9,909E-03 0,04768107 ! response to hydrogen peroxide GO:0042542 42 29 1,000 9,931E-03 0,04768431 ! ovulation cycle process GO:0022602 41 29 1,000 9,931E-03 0,04758497 ! regulation of axonogenesis GO:0050770 51 29 1,000 9,931E-03 0,04748604 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 9,931E-03 0,04738752 ! telencephalon development GO:0021537 52 29 1,000 9,931E-03 0,04728941 ! tissue homeostasis GO:0001894 42 29 1,000 9,931E-03 0,04719171 GO:0048871|multicellular organismal homeostasis, ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,01055552 0,0500571 GO:0060538|skeletal muscle organ development, ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,01060438 0,05018533 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,01060438 0,05008228 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,01060438 0,04997966 ! ovulation cycle GO:0042698 43 30 1,000 0,01060438 0,04987745 ! hindbrain development GO:0030902 45 30 1,000 0,01060438 0,04977566 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,01060438 0,04967428 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01060438 0,04957332 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01060438 0,04947276 ! response to heat GO:0009408 41 30 1,000 0,01060438 0,04937262 ! reproductive developmental process GO:0003006 127 89 2,000 0,0112256 0,05215936 ! regulation of T cell activation GO:0050863 128 89 2,000 0,0112256 0,0520542 ! mammary gland development GO:0030879 57 31 1,000 0,01129766 0,05228292 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,01129766 0,05217793 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,01129766 0,05207336 ! segmentation GO:0035282 41 31 1,000 0,01129766 0,05196922 ! metanephros development GO:0001656 58 31 1,000 0,01129766 0,05186549 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01129766 0,05176217 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 0,01129766 0,05165926 ! meiosis I GO:0007127 52 32 1,000 0,01201039 0,05480931 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,01201039 0,05470078 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01201039 0,05459268 ! regulation of protein stability GO:0031647 48 32 1,000 0,01201039 0,054485 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01201039 0,05437774 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,01201039 0,05427091 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01201039 0,0541645 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,01274236 0,05735309 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,01274236 0,05724107 ! ear morphogenesis GO:0042471 42 33 1,000 0,01274236 0,05712949 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,01274236 0,05701834 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 0,01274236 0,05690763 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,01274236 0,05679734 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01274236 0,05668748 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01274236 0,05657805 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,01349336 0,05979715 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,01349336 0,05968215 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,01349336 0,0595676 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01349336 0,05945348 ! neuron migration GO:0001764 46 34 1,000 0,01349336 0,05933981 ! female gamete generation GO:0007292 43 34 1,000 0,01349336 0,05922656 ! embryonic organ development GO:0048568 45 34 1,000 0,01349336 0,05911375 ! maintenance of protein location GO:0045185 65 35 1,000 0,01426316 0,06236744 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01426316 0,06224909 ! pigment metabolic process GO:0042440 61 35 1,000 0,01426316 0,0621312 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,01426316 0,06201375 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01505157 0,06531812 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01505157 0,06519511 ! negative regulation of binding GO:0051100 58 36 1,000 0,01505157 0,06507257 ! tissue remodeling GO:0048771 62 36 1,000 0,01505157 0,06495048 ! neural tube development GO:0021915 50 36 1,000 0,01505157 0,06482885 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,01505157 0,06470767 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,01505157 0,06458695 GO:0006073|cellular glucan metabolic process, ! learning GO:0007612 67 37 1,000 0,01585836 0,06792222 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,01668334 0,07132281 ! gliogenesis GO:0042063 71 38 1,000 0,01668334 0,07119049 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,01668334 0,07105865 ! maintenance of location in cell GO:0051651 69 38 1,000 0,01668334 0,07092731 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,01752628 0,07437353 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,01752628 0,07423656 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,01752628 0,0741001 ! male sex differentiation GO:0046661 53 39 1,000 0,01752628 0,07396414 ! chromatin remodeling GO:0006338 68 39 1,000 0,01752628 0,07382867 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,01752628 0,0736937 ! developmental growth GO:0048589 62 39 1,000 0,01752628 0,07355922 ! cell growth GO:0016049 61 39 1,000 0,01752628 0,07342524 ! synapse organization GO:0050808 55 39 1,000 0,01752628 0,07329173 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,018387 0,07675155 ! peptide metabolic process GO:0006518 56 40 1,000 0,018387 0,07661251 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,018387 0,07647397 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,01926528 0,07998222 ! protein amino acid lipidation GO:0006497 62 41 1,000 0,01926528 0,07983811 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,01926528 0,07969452 ! glucose transport GO:0015758 52 41 1,000 0,01926528 0,07955144 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01926528 0,07940888 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,02016093 0,08295194 ! hexose transport GO:0008645 54 42 1,000 0,02016093 0,08280382 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 1,000 0,02016093 0,08265622 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,02016093 0,08250914 ! regulation of cell shape GO:0008360 78 42 1,000 0,02016093 0,08236259 ! positive regulation of binding GO:0051099 59 43 1,000 0,02107374 0,085939 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,02107374 0,0857869 ! neuromuscular process GO:0050905 79 43 1,000 0,02107374 0,08563533 ! activation of caspase activity GO:0006919 65 43 1,000 0,02107374 0,0854843 ! vesicle organization GO:0016050 79 43 1,000 0,02107374 0,0853338 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,02200351 0,08894213 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,02200351 0,08878609 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,02200351 0,0886306 ! lipoprotein biosynthetic process GO:0042158 67 45 1,000 0,02295005 0,09228167 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,02295005 0,09212062 ! cell maturation GO:0048469 60 45 1,000 0,02295005 0,09196013 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,02391316 0,09565264 ! histone modification GO:0016570 68 46 1,000 0,02391316 0,09548657 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,02489265 0,09922546 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02489265 0,09905379 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02576014 0,10232869 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02576014 0,10215227 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02576014 0,10197644 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02576014 0,10180123 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02576014 0,10162661 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02576014 0,10145259 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02576014 0,10127917 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02576014 0,10110634 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02576014 0,1009341 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02576014 0,10076244 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02576014 0,10059137 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02576014 0,10042087 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02576014 0,10025095 ! tongue development GO:0043586 6 5 0,000 0,02576014 0,10008161 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02576014 0,09991284 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02576014 0,09974464 ! cobalt ion transport GO:0006824 9 5 0,000 0,02576014 0,099577 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02576014 0,09940992 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02576014 0,09924341 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02576014 0,09907745 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02576014 0,09891204 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02576014 0,09874719 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02576014 0,09858289 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02576014 0,09841913 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02576014 0,09825591 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02576014 0,09809324 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02576014 0,0979311 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02576014 0,0977695 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02576014 0,09760843 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02576014 0,09744789 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02576014 0,09728787 ! malate metabolic process GO:0006108 7 5 0,000 0,02576014 0,09712838 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02576014 0,09696942 ! behavioral response to pain GO:0048266 7 5 0,000 0,02576014 0,09681097 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02576014 0,09665304 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02576014 0,09649563 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02576014 0,09633872 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02576014 0,09618233 ! mating behavior GO:0007617 6 5 0,000 0,02576014 0,09602644 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02576014 0,09587106 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02576014 0,09571618 ! rhythmic behavior GO:0007622 12 5 0,000 0,02576014 0,0955618 ! copulation GO:0007620 7 5 0,000 0,02576014 0,09540791 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02576014 0,09525452 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02576014 0,09510163 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02576014 0,09494922 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02576014 0,0947973 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02576014 0,09464587 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02576014 0,09449492 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02576014 0,09434445 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02576014 0,09419446 ! lymph vessel development GO:0001945 7 5 0,000 0,02576014 0,09404494 ! endochondral ossification GO:0001958 12 5 0,000 0,02576014 0,0938959 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02576014 0,09374733 ! parathyroid gland development GO:0060017 8 5 0,000 0,02576014 0,09359923 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02576014 0,0934516 ! anagen GO:0042640 6 5 0,000 0,02576014 0,09330443 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02576014 0,09315773 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02576014 0,09301148 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02576014 0,0928657 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02576014 0,09272037 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02576014 0,09257549 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02576014 0,09243107 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02576014 0,09228709 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02576014 0,09214357 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02576014 0,09200049 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02576014 0,09185785 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02576014 0,09171566 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02576014 0,0915739 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02576014 0,09143258 ! ovulation GO:0030728 6 5 0,000 0,02576014 0,0912917 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02576014 0,09115125 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02576014 0,09101124 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02576014 0,09087165 ! response to pH GO:0009268 9 5 0,000 0,02576014 0,09073249 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02576014 0,09059375 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02576014 0,09045544 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02576014 0,09031755 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02576014 0,09018008 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02576014 0,09004303 ! polyol catabolic process GO:0046174 7 5 0,000 0,02576014 0,08990639 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02576014 0,08977017 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02576014 0,08963436 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02576014 0,08949896 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02576014 0,08936397 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02576014 0,08922939 ! urea metabolic process GO:0019627 6 5 0,000 0,02576014 0,08909521 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02576014 0,08896143 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02576014 0,08882806 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02576014 0,08869508 ! neutrophil activation GO:0042119 5 5 0,000 0,02576014 0,0885625 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02576014 0,08843032 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02576014 0,08829853 ! response to food GO:0032094 5 5 0,000 0,02576014 0,08816713 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02576014 0,08803613 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02576014 0,08790551 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02576014 0,08777528 ! forebrain neuron development GO:0021884 7 5 0,000 0,02576014 0,08764544 ! melanosome organization GO:0032438 7 5 0,000 0,02576014 0,08751597 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02576014 0,08738689 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02576014 0,08725819 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02576014 0,08712987 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02576014 0,08700193 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02576014 0,08687436 ! nucleoside transport GO:0015858 6 5 0,000 0,02576014 0,08674717 ! nucleoside salvage GO:0043174 7 5 0,000 0,02576014 0,08662034 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02576014 0,08649389 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02576014 0,0863678 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02576014 0,08624209 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02576014 0,08611674 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02576014 0,08599175 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02576014 0,08586712 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02576014 0,08574286 ! depyrimidination GO:0045008 8 5 0,000 0,02576014 0,08561895 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02576014 0,0854954 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02576014 0,08537221 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02576014 0,08524937 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02576014 0,08512689 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02576014 0,08500475 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02576014 0,08488297 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02576014 0,08476154 ! monocyte differentiation GO:0030224 8 5 0,000 0,02576014 0,08464045 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02576014 0,08451971 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02576014 0,08439931 ! centrosome duplication GO:0051298 5 5 0,000 0,02576014 0,08427925 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02576014 0,08415954 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02576014 0,08404016 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02576014 0,08392112 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02576014 0,08380242 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02576014 0,08368406 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02576014 0,08356603 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02576014 0,08344833 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02576014 0,08333096 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02576014 0,08321392 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02576014 0,08309721 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02576014 0,08298083 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02576014 0,08286477 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02576014 0,08274904 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02576014 0,08263363 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02576014 0,08251854 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02576014 0,08240377 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02576014 0,08228933 ! neural tube patterning GO:0021532 6 5 0,000 0,02576014 0,08217519 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02576014 0,08206138 ! histone demethylation GO:0016577 9 5 0,000 0,02576014 0,08194788 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02576014 0,08183469 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02576014 0,08172181 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02576014 0,08160925 ! enteric nervous system development GO:0048484 8 5 0,000 0,02576014 0,08149699 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02576014 0,08138505 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02576014 0,08127341 ! transcription termination GO:0006353 8 5 0,000 0,02576014 0,08116207 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02576014 0,08105105 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02576014 0,08094032 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02576014 0,0808299 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02576014 0,08071977 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02576014 0,08060995 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02576014 0,08050043 GO:0015991|ATP hydrolysis coupled proton transport, ! protein destabilization GO:0031648 6 5 0,000 0,02576014 0,0803912 ! apical protein localization GO:0045176 6 5 0,000 0,02576014 0,08028227 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02576014 0,08017363 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02576014 0,08006529 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02576014 0,07995724 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02576014 0,07984948 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02576014 0,07974201 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02576014 0,07963483 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02576014 0,07952794 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02576014 0,07942133 GO:0007439|ectodermal gut development, ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02576014 0,07931501 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02576014 0,07920898 ! neural plate development GO:0001840 6 5 0,000 0,02576014 0,07910322 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02576014 0,07899775 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02576014 0,07889256 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02576014 0,07878765 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02576014 0,07868302 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02576014 0,07857867 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02576014 0,07847459 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02576014 0,07837079 ! spindle assembly GO:0051225 5 5 0,000 0,02576014 0,07826726 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02576014 0,078164 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02576014 0,07806102 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02576014 0,07795831 ! organ regeneration GO:0031100 7 5 0,000 0,02576014 0,07785587 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02576014 0,07775369 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02576014 0,07765179 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02576014 0,07755015 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02576014 0,07744878 GO:0055081|anion homeostasis, ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,02588832 0,07773255 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,02588832 0,07763121 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,02588832 0,07753012 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,02588832 0,0774293 GO:0019724|B cell mediated immunity, ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,02588832 0,07732875 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,02689999 0,08024639 ! germ cell development GO:0007281 68 49 1,000 0,02689999 0,08014244 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,02689999 0,08003877 ! maintenance of location GO:0051235 84 49 1,000 0,02689999 0,07993536 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,02792745 0,08288148 ! membrane fusion GO:0006944 80 50 1,000 0,02792745 0,08277467 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,02792745 0,08266814 ! lipid modification GO:0030258 73 50 1,000 0,02792745 0,08256188 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,02792745 0,0824559 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,02792745 0,08235019 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,02897054 0,08531657 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,02897054 0,08520747 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,02897054 0,08509865 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,02897054 0,08499011 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03002906 0,08798322 ! aging GO:0007568 79 52 1,000 0,03002906 0,08787128 ! tRNA transcription GO:0009304 11 6 0,000 0,03083285 0,09010871 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03083285 0,08999436 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03083285 0,0898803 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03083285 0,08976653 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03083285 0,08965304 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03083285 0,08953984 ! regulation of helicase activity GO:0051095 11 6 0,000 0,03083285 0,08942693 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03083285 0,0893143 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03083285 0,08920196 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03083285 0,0890899 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03083285 0,08897811 ! prostate gland development GO:0030850 9 6 0,000 0,03083285 0,08886661 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03083285 0,08875539 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03083285 0,08864445 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03083285 0,08853378 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03083285 0,08842339 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03083285 0,08831327 GO:0046463|acylglycerol biosynthetic process, ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03083285 0,08820343 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03083285 0,08809386 ! neuron adhesion GO:0007158 9 6 0,000 0,03083285 0,08798456 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03083285 0,08787554 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03083285 0,08776678 ! signal peptide processing GO:0006465 8 6 0,000 0,03083285 0,08765829 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03083285 0,08755007 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03083285 0,08744212 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03083285 0,08733443 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03083285 0,08722701 ! opsonization GO:0008228 8 6 0,000 0,03083285 0,08711985 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03083285 0,08701295 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03083285 0,08690632 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03083285 0,08679995 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03083285 0,08669383 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03083285 0,08658798 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03083285 0,08648239 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03083285 0,08637705 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03083285 0,08627197 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03083285 0,08616714 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03083285 0,08606257 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03083285 0,08595825 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03083285 0,08585419 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03083285 0,08575037 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03083285 0,08564681 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03083285 0,08554349 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03083285 0,08544043 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03083285 0,08533761 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03083285 0,08523504 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03083285 0,08513272 ! thymic T cell selection GO:0045061 12 6 0,000 0,03083285 0,08503064 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03083285 0,08492881 ! drug transport GO:0015893 6 6 0,000 0,03083285 0,08482722 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03083285 0,08472587 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,03083285 0,08462477 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03083285 0,08452391 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03083285 0,08442328 ! histidine metabolic process GO:0006547 6 6 0,000 0,03083285 0,0843229 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03083285 0,08422275 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03083285 0,08412284 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03083285 0,08402317 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03083285 0,08392374 ! adenohypophysis development GO:0021984 10 6 0,000 0,03083285 0,08382454 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03083285 0,08372557 ! hyperosmotic response GO:0006972 8 6 0,000 0,03083285 0,08362684 ! microtubule nucleation GO:0007020 10 6 0,000 0,03083285 0,08352834 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03083285 0,08343007 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03083285 0,08333203 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03083285 0,08323422 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03083285 0,08313664 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03083285 0,08303929 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03083285 0,08294217 ! response to dietary excess GO:0002021 7 6 0,000 0,03083285 0,08284528 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03083285 0,08274861 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03083285 0,08265216 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03083285 0,08255595 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03083285 0,08245995 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03083285 0,08236418 ! organic alcohol transport GO:0015850 9 6 0,000 0,03083285 0,08226863 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03083285 0,0821733 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03083285 0,08207819 ! carnitine transport GO:0015879 8 6 0,000 0,03083285 0,0819833 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03083285 0,08188863 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03083285 0,08179418 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03083285 0,08169995 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03083285 0,08160593 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03083285 0,08151213 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03083285 0,08141855 ! parturition GO:0007567 12 6 0,000 0,03083285 0,08132518 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03083285 0,08123202 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03083285 0,08113908 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03083285 0,08104635 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03083285 0,08095383 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03083285 0,08086152 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03083285 0,08076943 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03083285 0,08067754 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03083285 0,08058586 ! macrophage differentiation GO:0030225 10 6 0,000 0,03083285 0,08049439 ! astrocyte development GO:0014002 14 6 0,000 0,03083285 0,08040313 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03083285 0,08031207 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03083285 0,08022122 ! interaction with symbiont GO:0051702 8 6 0,000 0,03083285 0,08013057 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03083285 0,08004013 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03083285 0,0799499 ! eating behavior GO:0042755 6 6 0,000 0,03083285 0,07985986 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03083285 0,07977003 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03083285 0,0796804 ! response to copper ion GO:0046688 9 6 0,000 0,03083285 0,07959097 ! DNA topological change GO:0006265 8 6 0,000 0,03083285 0,07950175 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03083285 0,07941272 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03083285 0,07932389 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03083285 0,07923526 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03083285 0,07914683 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03083285 0,07905859 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03083285 0,07897055 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03083285 0,07888271 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03083285 0,07879506 ! gas homeostasis GO:0033483 11 6 0,000 0,03083285 0,07870761 ! hair follicle maturation GO:0048820 7 6 0,000 0,03083285 0,07862035 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03083285 0,07853329 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03083285 0,07844641 ! Schwann cell development GO:0014044 14 6 0,000 0,03083285 0,07835973 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03083285 0,07827324 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03083285 0,07818694 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03083285 0,07810083 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03083285 0,07801491 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03083285 0,07792918 ! histone ubiquitination GO:0016574 7 6 0,000 0,03083285 0,07784364 ! regulation of meiosis GO:0040020 10 6 0,000 0,03083285 0,07775829 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03083285 0,07767312 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03083285 0,07758814 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03083285 0,07750334 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03083285 0,07741873 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03083285 0,0773343 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03083285 0,07725006 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03083285 0,077166 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03083285 0,07708213 ! receptor internalization GO:0031623 9 6 0,000 0,03083285 0,07699843 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03083285 0,07691492 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03083285 0,07683159 ! protein deubiquitination GO:0016579 8 6 0,000 0,03083285 0,07674844 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03083285 0,07666547 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,03083285 0,07658267 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03083285 0,07650006 ! axonal fasciculation GO:0007413 9 6 0,000 0,03083285 0,07641763 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03083285 0,07633537 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03083285 0,07625329 ! midbrain development GO:0030901 6 6 0,000 0,03083285 0,07617138 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03083285 0,07608965 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03083285 0,0760081 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03083285 0,07592672 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03083285 0,07584552 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03083285 0,07576448 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03083285 0,07568363 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03083285 0,07560294 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03083285 0,07552242 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03083285 0,07544208 ! adult feeding behavior GO:0008343 6 6 0,000 0,03083285 0,07536191 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03083285 0,07528191 ! blastocyst growth GO:0001832 15 6 0,000 0,03083285 0,07520208 ! pigment granule transport GO:0051904 12 6 0,000 0,03083285 0,07512241 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03083285 0,07504292 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03083285 0,07496359 ! catecholamine transport GO:0051937 7 6 0,000 0,03083285 0,07488443 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03083285 0,07480544 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03083285 0,07472661 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03083285 0,07464795 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03083285 0,07456946 ! protein prenylation GO:0018342 10 6 0,000 0,03083285 0,07449113 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03083285 0,07441297 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03083285 0,07433497 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03083285 0,07425713 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03083285 0,07417945 ! kidney development GO:0001822 90 53 1,000 0,03110281 0,07475076 ! single fertilization GO:0007338 59 53 1,000 0,03110281 0,07467273 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,03219163 0,07720621 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,03219163 0,07712579 ! detection of external stimulus GO:0009581 66 54 1,000 0,03219163 0,07704553 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,03219163 0,07696545 ! carbohydrate transport GO:0008643 74 57 1,000 0,03554664 0,08489853 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,03554664 0,08481046 GO:0048609|reproductive process in a multicellular organism, ! secondary metabolic process GO:0019748 84 57 1,000 0,03554664 0,08472257 ! developmental maturation GO:0021700 75 57 1,000 0,03554664 0,08463487 ! gonad development GO:0008406 79 57 1,000 0,03554664 0,08454734 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03587944 0,08525074 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03587944 0,08516276 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03587944 0,08507496 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03587944 0,08498735 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03587944 0,08489991 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03587944 0,08481266 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03587944 0,08472558 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03587944 0,08463868 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03587944 0,08455196 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03587944 0,08446542 ! reproductive behavior GO:0019098 12 7 0,000 0,03587944 0,08437905 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03587944 0,08429286 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,03587944 0,08420685 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03587944 0,08412101 ! oligopeptide transport GO:0006857 11 7 0,000 0,03587944 0,08403535 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03587944 0,08394986 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03587944 0,08386455 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03587944 0,08377941 ! RNA methylation GO:0001510 11 7 0,000 0,03587944 0,08369444 ! pericardium development GO:0060039 8 7 0,000 0,03587944 0,08360964 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03587944 0,08352501 ! fibril organization GO:0043206 13 7 0,000 0,03587944 0,08344056 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03587944 0,08335628 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03587944 0,08327216 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03587944 0,08318822 ! lipoprotein transport GO:0042953 9 7 0,000 0,03587944 0,08310445 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03587944 0,08302084 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03587944 0,0829374 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03587944 0,08285413 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03587944 0,08277103 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03587944 0,08268809 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03587944 0,08260532 ! chemosensory behavior GO:0007635 9 7 0,000 0,03587944 0,08252271 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03587944 0,08244027 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03587944 0,082358 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03587944 0,08227589 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03587944 0,08219394 ! reflex GO:0060004 12 7 0,000 0,03587944 0,08211215 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03587944 0,08203053 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03587944 0,08194907 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03587944 0,08186777 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03587944 0,08178663 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03587944 0,08170566 ! spinal cord patterning GO:0021511 7 7 0,000 0,03587944 0,08162484 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03587944 0,08154418 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03587944 0,08146369 ! adrenal gland development GO:0030325 17 7 0,000 0,03587944 0,08138335 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03587944 0,08130317 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03587944 0,08122314 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03587944 0,08114328 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03587944 0,08106357 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03587944 0,08098402 ! endosome organization GO:0007032 10 7 0,000 0,03587944 0,08090462 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03587944 0,08082538 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03587944 0,0807463 GO:0021940|positive regulation of granule cell precursor proliferation, ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03587944 0,08066737 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03587944 0,08058859 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03587944 0,08050997 ! galactose metabolic process GO:0006012 10 7 0,000 0,03587944 0,0804315 ! vesicle fusion GO:0006906 15 7 0,000 0,03587944 0,08035318 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03587944 0,08027501 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03587944 0,080197 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03587944 0,08011914 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03587944 0,08004143 ! retinol metabolic process GO:0042572 9 7 0,000 0,03587944 0,07996387 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03587944 0,07988646 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03587944 0,0798092 ! rRNA modification GO:0000154 12 7 0,000 0,03587944 0,07973209 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03587944 0,07965513 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03587944 0,07957832 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03587944 0,07950165 ! intermediate filament organization GO:0045109 11 7 0,000 0,03587944 0,07942513 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03587944 0,07934876 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03587944 0,07927254 ! fibrinolysis GO:0042730 9 7 0,000 0,03587944 0,07919646 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03587944 0,07912053 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03587944 0,07904475 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03587944 0,0789691 ! response to tropane GO:0014073 13 7 0,000 0,03587944 0,07889361 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03587944 0,07881826 ! melanosome localization GO:0032400 10 7 0,000 0,03587944 0,07874305 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03587944 0,07866798 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03587944 0,07859306 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03587944 0,07851828 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03587944 0,07844364 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03587944 0,07836915 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03587944 0,0782948 ! mast cell activation GO:0045576 9 7 0,000 0,03587944 0,07822058 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03587944 0,07814651 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03587944 0,07807258 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03587944 0,07799878 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,03587944 0,07792513 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03587944 0,07785162 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,03587944 0,07777824 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03587944 0,077705 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03587944 0,0776319 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03587944 0,07755894 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03587944 0,07748612 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03587944 0,07741343 ! response to tumor cell GO:0002347 12 7 0,000 0,03587944 0,07734088 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03587944 0,07726846 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03587944 0,07719618 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03587944 0,07712403 ! diuresis GO:0030146 12 7 0,000 0,03587944 0,07705202 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03587944 0,07698014 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03587944 0,0769084 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03587944 0,07683679 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03587944 0,07676532 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03587944 0,07669397 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03587944 0,07662276 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03587944 0,07655168 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03587944 0,07648074 ! lymph node development GO:0048535 9 7 0,000 0,03587944 0,07640992 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03587944 0,07633924 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03587944 0,07626868 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03587944 0,07619826 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03587944 0,07612797 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03587944 0,0760578 ! ATP catabolic process GO:0006200 10 7 0,000 0,03587944 0,07598777 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03587944 0,07591786 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03587944 0,07584808 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03587944 0,07577843 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03587944 0,07570891 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03587944 0,07563952 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03587944 0,07557025 ! muscle adaptation GO:0043500 12 7 0,000 0,03587944 0,07550111 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03587944 0,0754321 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03587944 0,07536321 ! retina homeostasis GO:0001895 9 7 0,000 0,03587944 0,07529445 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03587944 0,07522581 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03587944 0,0751573 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03587944 0,07508891 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03587944 0,07502065 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03587944 0,07495251 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03587944 0,0748845 ! viral reproductive process GO:0022415 87 58 1,000 0,0366939 0,07651493 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,0366939 0,07644562 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,0366939 0,07637644 ! activation of MAPK activity GO:0000187 84 59 1,000 0,03785532 0,07872264 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,03785532 0,07865152 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,03903073 0,08102047 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,03903073 0,08094741 GO:0035113|embryonic appendage morphogenesis, ! fertilization GO:0009566 68 60 1,000 0,03903073 0,08087448 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,04021996 0,08326363 ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,04021996 0,08318876 ! urogenital system development GO:0001655 101 61 1,000 0,04021996 0,08311401 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,04021996 0,0830394 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,04021996 0,08296493 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04090004 0,0842922 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04090004 0,08421673 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04090004 0,08414141 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04090004 0,08406621 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04090004 0,08399115 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04090004 0,08391623 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04090004 0,08384144 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04090004 0,08376678 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04090004 0,08369225 ! phosphate transport GO:0006817 10 8 0,000 0,04090004 0,08361786 ! N-glycan processing GO:0006491 12 8 0,000 0,04090004 0,0835436 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04090004 0,08346947 ! UTP metabolic process GO:0046051 8 8 0,000 0,04090004 0,08339547 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04090004 0,08332161 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04090004 0,08324787 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04090004 0,08317426 ! succinate metabolic process GO:0006105 14 8 0,000 0,04090004 0,08310079 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04090004 0,08302744 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04090004 0,08295423 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04090004 0,08288114 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04090004 0,08280818 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04090004 0,08273535 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04090004 0,08266265 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04090004 0,08259007 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04090004 0,08251763 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04090004 0,0824453 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04090004 0,08237311 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04090004 0,08230104 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04090004 0,0822291 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04090004 0,08215729 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04090004 0,0820856 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04090004 0,08201403 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04090004 0,08194259 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04090004 0,08187127 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04090004 0,08180008 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04090004 0,08172901 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04090004 0,08165807 ! macrophage activation GO:0042116 12 8 0,000 0,04090004 0,08158724 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04090004 0,08151654 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04090004 0,08144597 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04090004 0,08137551 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04090004 0,08130518 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04090004 0,08123497 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04090004 0,08116488 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04090004 0,08109491 ! ruffle organization GO:0031529 11 8 0,000 0,04090004 0,08102506 ! osteoblast development GO:0002076 13 8 0,000 0,04090004 0,08095533 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04090004 0,08088572 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04090004 0,08081623 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04090004 0,08074686 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04090004 0,08067761 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04090004 0,08060848 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04090004 0,08053946 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04090004 0,08047057 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04090004 0,08040179 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04090004 0,08033313 ! brain morphogenesis GO:0048854 20 8 0,000 0,04090004 0,08026458 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04090004 0,08019616 ! segment specification GO:0007379 10 8 0,000 0,04090004 0,08012785 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,04090004 0,08005965 ! cellular extravasation GO:0045123 11 8 0,000 0,04090004 0,07999158 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04090004 0,07992361 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04090004 0,07985577 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04090004 0,07978803 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04090004 0,07972042 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04090004 0,07965291 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04090004 0,07958553 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04090004 0,07951825 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04090004 0,07945109 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04090004 0,07938404 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04090004 0,07931711 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04090004 0,07925029 ! icosanoid secretion GO:0032309 12 8 0,000 0,04090004 0,07918358 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04090004 0,07911698 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04090004 0,0790505 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04090004 0,07898412 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04090004 0,07891786 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04090004 0,07885171 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04090004 0,07878567 ! sterol catabolic process GO:0016127 9 8 0,000 0,04090004 0,07871974 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04090004 0,07865392 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04090004 0,07858821 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04090004 0,07852261 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04090004 0,07845712 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04090004 0,07839174 ! S phase GO:0051320 8 8 0,000 0,04090004 0,07832647 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04090004 0,07826131 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,04090004 0,07819625 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04090004 0,07813131 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04090004 0,07806647 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04090004 0,07800174 ! hormone catabolic process GO:0042447 13 8 0,000 0,04090004 0,07793711 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04090004 0,07787259 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04090004 0,07780818 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04090004 0,07774388 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04090004 0,07767968 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04090004 0,07761559 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04090004 0,0775516 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04090004 0,07748772 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04090004 0,07742394 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04090004 0,07736027 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04090004 0,07729671 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04090004 0,07723325 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04090004 0,07716989 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04090004 0,07710663 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,04142282 0,07802825 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,04142282 0,0779644 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,04263917 0,08018813 ! viral reproduction GO:0016032 92 63 1,000 0,04263917 0,08012262 ! regulation of lipase activity GO:0060191 109 63 1,000 0,04263917 0,08005721 ! appendage morphogenesis GO:0035107 93 64 1,000 0,04386881 0,08229875 GO:0035108|limb morphogenesis, ! reproductive structure development GO:0048608 90 65 1,000 0,04511159 0,08456126 ! regulation of caspase activity GO:0043281 97 65 1,000 0,04511159 0,0844924 ! appendage development GO:0048736 94 65 1,000 0,04511159 0,08442365 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,04511159 0,08435501 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,04511159 0,08428648 ! defense response to bacterium GO:0042742 73 65 1,000 0,04511159 0,08421807 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,04511159 0,08414977 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,04511159 0,08408157 ! protein oligomerization GO:0051259 100 65 1,000 0,04511159 0,08401349 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04589478 0,08540291 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04589478 0,08533387 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04589478 0,08526494 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04589478 0,08519612 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04589478 0,08512742 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,04589478 0,08505882 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04589478 0,08499033 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04589478 0,08492196 ! GTP metabolic process GO:0046039 9 9 0,000 0,04589478 0,08485369 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04589478 0,08478554 ! social behavior GO:0035176 14 9 0,000 0,04589478 0,08471749 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04589478 0,08464956 ! artery development GO:0060840 19 9 0,000 0,04589478 0,08458173 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04589478 0,08451401 ! response to pain GO:0048265 16 9 0,000 0,04589478 0,0844464 ! protein complex disassembly GO:0043241 17 9 0,000 0,04589478 0,08437889 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04589478 0,0843115 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04589478 0,08424421 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04589478 0,08417703 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04589478 0,08410996 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04589478 0,08404299 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04589478 0,08397613 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04589478 0,08390938 ! protein targeting to ER GO:0045047 19 9 0,000 0,04589478 0,08384273 ! endoderm development GO:0007492 12 9 0,000 0,04589478 0,08377619 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04589478 0,08370975 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04589478 0,08364342 ! arginine catabolic process GO:0006527 10 9 0,000 0,04589478 0,08357719 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04589478 0,08351107 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04589478 0,08344506 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04589478 0,08337914 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04589478 0,08331334 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04589478 0,08324763 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04589478 0,08318203 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04589478 0,08311653 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04589478 0,08305114 ! mannose metabolic process GO:0006013 9 9 0,000 0,04589478 0,08298585 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04589478 0,08292066 ! receptor clustering GO:0043113 15 9 0,000 0,04589478 0,08285557 ! epithelial cell development GO:0002064 10 9 0,000 0,04589478 0,08279058 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04589478 0,0827257 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04589478 0,08266092 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04589478 0,08259624 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04589478 0,08253166 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04589478 0,08246718 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04589478 0,08240281 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,04589478 0,08233853 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04589478 0,08227435 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04589478 0,08221028 ! DNA ligation GO:0006266 14 9 0,000 0,04589478 0,0821463 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04589478 0,08208242 ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04589478 0,08201864 ! erythrocyte development GO:0048821 11 9 0,000 0,04589478 0,08195497 ! renal water homeostasis GO:0003091 14 9 0,000 0,04589478 0,08189139 ! postreplication repair GO:0006301 11 9 0,000 0,04589478 0,0818279 ! mRNA cleavage GO:0006379 13 9 0,000 0,04589478 0,08176452 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04589478 0,08170124 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04589478 0,08163805 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04589478 0,08157496 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04589478 0,08151197 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04589478 0,08144907 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04589478 0,08138627 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,04589478 0,08132357 ! acid secretion GO:0046717 14 9 0,000 0,04589478 0,08126097 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04589478 0,08119846 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04589478 0,08113605 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04589478 0,08107373 ! purine base metabolic process GO:0006144 18 9 0,000 0,04589478 0,08101151 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04589478 0,08094938 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04589478 0,08088735 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04589478 0,08082542 ! detection of calcium ion GO:0005513 13 9 0,000 0,04589478 0,08076358 ! blastocyst formation GO:0001825 12 9 0,000 0,04589478 0,08070183 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04589478 0,08064018 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04589478 0,08057862 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04589478 0,08051716 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04589478 0,08045579 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04589478 0,08039451 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04589478 0,08033333 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04589478 0,08027224 ! prepulse inhibition GO:0060134 14 9 0,000 0,04589478 0,08021124 ! embryonic placenta development GO:0001892 12 9 0,000 0,04589478 0,08015034 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04589478 0,08008953 ! insulin secretion GO:0030073 17 9 0,000 0,04589478 0,08002881 ! sequestering of metal ion GO:0051238 11 9 0,000 0,04589478 0,07996818 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04589478 0,07990764 ! nucleus localization GO:0051647 15 9 0,000 0,04589478 0,0798472 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04589478 0,07978684 ! axon guidance GO:0007411 99 66 1,000 0,04636734 0,0805475 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,04763589 0,08268872 ! acute inflammatory response GO:0002526 92 68 1,000 0,04891709 0,08484864 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,04891709 0,0847847 ! rhythmic process GO:0048511 105 68 1,000 0,04891709 0,08472086 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,05021076 0,08689597 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05086379 0,08795995 ! neuron fate specification GO:0048665 11 10 0,000 0,05086379 0,08789386 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05086379 0,08782787 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05086379 0,08776199 ! thyroid gland development GO:0030878 19 10 0,000 0,05086379 0,0876962 ! synapsis GO:0007129 13 10 0,000 0,05086379 0,08763051 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05086379 0,08756492 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05086379 0,08749942 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05086379 0,08743403 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,05086379 0,08736873 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05086379 0,08730353 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,05086379 0,08723842 ! androgen metabolic process GO:0008209 13 10 0,000 0,05086379 0,08717342 ! phospholipid efflux GO:0033700 16 10 0,000 0,05086379 0,08710851 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,05086379 0,0870437 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05086379 0,08697898 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,05086379 0,08691436 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,05086379 0,08684983 ! pathogenesis GO:0009405 13 10 0,000 0,05086379 0,08678541 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05086379 0,08672107 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05086379 0,08665683 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05086379 0,08659269 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05086379 0,08652864 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05086379 0,08646469 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05086379 0,08640083 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05086379 0,08633707 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05086379 0,0862734 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05086379 0,08620982 ! response to X-ray GO:0010165 16 10 0,000 0,05086379 0,08614634 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05086379 0,08608295 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05086379 0,08601965 ! forebrain cell migration GO:0021885 17 10 0,000 0,05086379 0,08595645 ! lipid digestion GO:0044241 15 10 0,000 0,05086379 0,08589334 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05086379 0,08583032 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05086379 0,0857674 ! UV protection GO:0009650 14 10 0,000 0,05086379 0,08570456 ! entry into host cell GO:0030260 20 10 0,000 0,05086379 0,08564182 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05086379 0,08557917 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,05086379 0,08551661 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05086379 0,08545415 ! regulation of organ growth GO:0046620 11 10 0,000 0,05086379 0,08539177 ! response to dsRNA GO:0043331 18 10 0,000 0,05086379 0,08532949 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05086379 0,08526729 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05086379 0,08520519 ! embryonic axis specification GO:0000578 12 10 0,000 0,05086379 0,08514318 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05086379 0,08508126 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05086379 0,08501942 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05086379 0,08495768 ! cranial nerve development GO:0021545 12 10 0,000 0,05086379 0,08489603 ! fucose catabolic process GO:0019317 16 10 0,000 0,05086379 0,08483446 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,05086379 0,08477299 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05086379 0,08471161 ! protein sumoylation GO:0016925 12 10 0,000 0,05086379 0,08465031 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05086379 0,0845891 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05086379 0,08452798 ! zymogen activation GO:0031638 14 10 0,000 0,05086379 0,08446695 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05086379 0,08440601 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05086379 0,08434515 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05086379 0,08428439 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05086379 0,08422371 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05086379 0,08416311 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05086379 0,08410261 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05086379 0,08404219 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05086379 0,08398186 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05086379 0,08392161 ! detection of bacterium GO:0016045 10 10 0,000 0,05086379 0,08386145 ! embryonic gut development GO:0048566 11 10 0,000 0,05086379 0,08380138 ! activation of innate immune response GO:0002218 10 10 0,000 0,05086379 0,08374139 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05086379 0,08368149 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05086379 0,08362168 ! developmental induction GO:0031128 13 10 0,000 0,05086379 0,08356195 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05086379 0,0835023 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05086379 0,08344274 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05086379 0,08338327 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05086379 0,08332388 ! response to metal ion GO:0010038 103 70 1,000 0,05151674 0,08433345 ! eye development GO:0001654 111 70 1,000 0,05151674 0,08427347 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,05283488 0,08636832 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,05283488 0,08630698 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,05283488 0,08624572 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,05416501 0,08835428 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,05416501 0,08829166 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,05416501 0,08822913 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,05550699 0,09035108 ! rRNA transcription GO:0009303 17 11 0,000 0,05580721 0,09077552 ! respiratory burst GO:0045730 14 11 0,000 0,05580721 0,09071137 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,05580721 0,09064731 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,05580721 0,09058334 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,05580721 0,09051946 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,05580721 0,09045566 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,05580721 0,09039196 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,05580721 0,09032835 ! RNA polyadenylation GO:0043631 19 11 0,000 0,05580721 0,09026483 ! mating GO:0007618 14 11 0,000 0,05580721 0,0902014 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,05580721 0,09013805 ! T cell proliferation GO:0042098 20 11 0,000 0,05580721 0,0900748 ! bone resorption GO:0045453 16 11 0,000 0,05580721 0,09001163 ! regulated secretory pathway GO:0045055 14 11 0,000 0,05580721 0,08994856 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,05580721 0,08988557 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,05580721 0,08982266 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,05580721 0,08975985 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,05580721 0,08969713 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,05580721 0,08963449 ! syncytium formation GO:0006949 15 11 0,000 0,05580721 0,08957194 ! plasma membrane organization GO:0007009 18 11 0,000 0,05580721 0,08950948 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,05580721 0,0894471 ! mitotic spindle organization GO:0007052 15 11 0,000 0,05580721 0,08938481 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,05580721 0,08932261 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,05580721 0,08926049 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,05580721 0,08919846 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,05580721 0,08913652 ! adult heart development GO:0007512 11 11 0,000 0,05580721 0,08907466 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,05580721 0,08901289 ! temperature homeostasis GO:0001659 16 11 0,000 0,05580721 0,0889512 ! L-glutamate transport GO:0015813 16 11 0,000 0,05580721 0,0888896 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,05580721 0,08882809 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,05580721 0,08876666 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,05580721 0,08870531 ! stem cell development GO:0048864 29 11 0,000 0,05580721 0,08864405 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,05580721 0,08858288 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,05580721 0,08852178 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,05580721 0,08846078 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,05580721 0,08839985 ! vasoconstriction GO:0042310 15 11 0,000 0,05580721 0,08833901 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,05580721 0,08827826 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,05580721 0,08821759 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,05580721 0,088157 ! ribosome assembly GO:0042255 13 11 0,000 0,05580721 0,08809649 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,05580721 0,08803607 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,05580721 0,08797573 ! chromatin silencing GO:0006342 19 11 0,000 0,05580721 0,08791547 ! nucleosome positioning GO:0016584 13 11 0,000 0,05580721 0,0878553 ! regulation of isotype switching GO:0045191 19 11 0,000 0,05580721 0,0877952 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,05580721 0,08773519 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,05580721 0,08767527 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,05580721 0,08761542 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,05580721 0,08755565 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,05580721 0,08749597 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,05580721 0,08743637 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,05580721 0,08737685 ! male genitalia development GO:0030539 13 11 0,000 0,05580721 0,08731741 ! cholesterol efflux GO:0033344 19 11 0,000 0,05580721 0,08725805 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,05580721 0,08719877 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,05580721 0,08713957 ! germ cell migration GO:0008354 18 11 0,000 0,05580721 0,08708045 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,05580721 0,08702142 ! defense response to fungus GO:0050832 12 11 0,000 0,05580721 0,08696246 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,05580721 0,08690358 ! lysogeny GO:0030069 18 11 0,000 0,05580721 0,08684478 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,05580721 0,08678606 ! acrosome reaction GO:0007340 13 11 0,000 0,05580721 0,08672742 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,05580721 0,08666886 ! blood coagulation GO:0007596 116 75 1,000 0,05822583 0,09036397 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,05822583 0,09030304 ! response to nutrient GO:0007584 104 75 1,000 0,05822583 0,09024219 ! regulation of ligase activity GO:0051340 114 75 1,000 0,05822583 0,09018142 ! amine biosynthetic process GO:0009309 97 76 1,000 0,05960239 0,09225134 ! lactation GO:0007595 20 12 0,000 0,06072516 0,09392594 ! reproductive cellular process GO:0048610 14 12 0,000 0,06072516 0,09386282 ! tRNA modification GO:0006400 14 12 0,000 0,06072516 0,09379978 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,06072516 0,09373683 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,06072516 0,09367396 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,06072516 0,09361118 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,06072516 0,09354848 ! non-recombinational repair GO:0000726 19 12 0,000 0,06072516 0,09348586 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,06072516 0,09342333 ! peroxisomal transport GO:0043574 21 12 0,000 0,06072516 0,09336088 ! cartilage condensation GO:0001502 18 12 0,000 0,06072516 0,09329852 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,06072516 0,09323623 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,06072516 0,09317403 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,06072516 0,09311192 ! heart looping GO:0001947 15 12 0,000 0,06072516 0,09304989 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,06072516 0,09298793 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,06072516 0,09292607 ! arginine metabolic process GO:0006525 13 12 0,000 0,06072516 0,09286428 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,06072516 0,09280258 ! methionine metabolic process GO:0006555 13 12 0,000 0,06072516 0,09274095 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,06072516 0,09267941 ! Golgi organization GO:0007030 18 12 0,000 0,06072516 0,09261796 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,06072516 0,09255658 ! monoamine transport GO:0015844 13 12 0,000 0,06072516 0,09249528 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06072516 0,09243407 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,06072516 0,09237294 ! L-amino acid transport GO:0015807 20 12 0,000 0,06072516 0,09231188 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,06072516 0,09225091 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,06072516 0,09219002 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,06072516 0,09212921 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06072516 0,09206848 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,06072516 0,09200782 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,06072516 0,09194725 ! cerebellum development GO:0021549 13 12 0,000 0,06072516 0,09188676 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,06072516 0,09182635 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,06072516 0,09176602 ! histone methylation GO:0016571 15 12 0,000 0,06072516 0,09170576 ! autonomic nervous system development GO:0048483 23 12 0,000 0,06072516 0,09164559 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,06072516 0,09158549 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,06072516 0,09152548 ! intestinal absorption GO:0050892 19 12 0,000 0,06072516 0,09146554 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,06072516 0,09140568 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,06072516 0,0913459 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,06072516 0,09128619 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,06072516 0,09122657 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,06072516 0,09116702 ! microspike assembly GO:0030035 23 12 0,000 0,06072516 0,09110755 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,06072516 0,09104816 ! response to cold GO:0009409 14 12 0,000 0,06072516 0,09098885 ! sex differentiation GO:0007548 105 77 1,000 0,06099017 0,09132643 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,06099017 0,09126701 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,06521934 0,09753217 GO:0010498|proteasomal protein catabolic process, ! forebrain development GO:0030900 131 80 1,000 0,06521934 0,09746879 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,06561778 0,09800058 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,06561778 0,09793699 ! cGMP metabolic process GO:0046068 16 13 0,000 0,06561778 0,09787347 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,06561778 0,09781004 ! water transport GO:0006833 17 13 0,000 0,06561778 0,09774669 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,06561778 0,09768343 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,06561778 0,09762024 ! lipid localization GO:0010876 24 13 0,000 0,06561778 0,09755714 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,06561778 0,09749412 ! organelle fusion GO:0048284 28 13 0,000 0,06561778 0,09743118 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,06561778 0,09736832 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,06561778 0,09730554 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,06561778 0,09724285 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,06561778 0,09718023 ! response to hexose stimulus GO:0009746 19 13 0,000 0,06561778 0,09711769 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,06561778 0,09705524 ! glutamate metabolic process GO:0006536 18 13 0,000 0,06561778 0,09699286 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,06561778 0,09693057 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,06561778 0,09686835 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,06561778 0,09680622 ! NAD metabolic process GO:0019674 21 13 0,000 0,06561778 0,09674416 ! bone mineralization GO:0030282 15 13 0,000 0,06561778 0,09668219 ! regulation of exocytosis GO:0017157 17 13 0,000 0,06561778 0,09662029 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,06561778 0,09655847 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,06561778 0,09649674 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,06561778 0,09643508 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,06561778 0,0963735 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,06561778 0,09631199 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,06561778 0,09625057 ! genitalia development GO:0048806 15 13 0,000 0,06561778 0,09618923 ! regulation of cellular pH GO:0030641 20 13 0,000 0,06561778 0,09612796 ! tissue regeneration GO:0042246 21 13 0,000 0,06561778 0,09606677 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,06561778 0,09600566 ! cofactor transport GO:0051181 19 13 0,000 0,06561778 0,09594463 ! NADP metabolic process GO:0006739 18 13 0,000 0,06561778 0,09588367 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,06561778 0,09582279 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,06561778 0,09576199 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,06561778 0,09570127 ! gas transport GO:0015669 18 13 0,000 0,06561778 0,09564062 ! heme biosynthetic process GO:0006783 20 13 0,000 0,06561778 0,09558005 ! regulation of axon extension GO:0030516 23 13 0,000 0,06561778 0,09551955 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,06561778 0,09545914 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,06561778 0,0953988 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,06561778 0,09533853 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,06561778 0,09527834 ! hemostasis GO:0007599 125 81 1,000 0,0666505 0,09671682 ! response to protein stimulus GO:0051789 111 81 1,000 0,0666505 0,09665584 ! regulation of neurological system process GO:0031644 122 81 1,000 0,0666505 0,09659493 ! ossification GO:0001503 134 82 1,000 0,06809215 0,09862213 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,06809215 0,09856007 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,07048519 0,10195971 ! superoxide anion generation GO:0042554 18 14 0,000 0,07048519 0,10189562 ! regulation of S phase GO:0033261 18 14 0,000 0,07048519 0,10183162 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,07048519 0,1017677 ! myotube differentiation GO:0014902 21 14 0,000 0,07048519 0,10170385 ! inositol metabolic process GO:0006020 20 14 0,000 0,07048519 0,10164009 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,07048519 0,1015764 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,07048519 0,1015128 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,07048519 0,10144927 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,07048519 0,10138583 ! gene silencing by RNA GO:0031047 20 14 0,000 0,07048519 0,10132246 ! response to cAMP GO:0051591 19 14 0,000 0,07048519 0,10125917 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,07048519 0,10119597 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,07048519 0,10113284 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,07048519 0,10106979 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,07048519 0,10100682 ! glycine metabolic process GO:0006544 22 14 0,000 0,07048519 0,10094392 ! pituitary gland development GO:0021983 23 14 0,000 0,07048519 0,10088111 ! cellular response to starvation GO:0009267 21 14 0,000 0,07048519 0,10081837 ! lysosomal transport GO:0007041 20 14 0,000 0,07048519 0,10075571 ! regulation of heart rate GO:0002027 23 14 0,000 0,07048519 0,10069313 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,07048519 0,10063063 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,07048519 0,1005682 ! embryo implantation GO:0007566 27 14 0,000 0,07048519 0,10050585 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,07048519 0,10044358 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,07048519 0,10038139 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,07048519 0,10031927 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,07048519 0,10025723 ! axon cargo transport GO:0008088 27 14 0,000 0,07048519 0,10019526 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,07048519 0,10013338 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,07048519 0,10007157 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07048519 0,10000983 ! mRNA splice site selection GO:0006376 26 14 0,000 0,07048519 0,09994817 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,07048519 0,09988659 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,07048519 0,09982509 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,07048519 0,09976365 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,07048519 0,0997023 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,07048519 0,09964102 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,07048519 0,09957981 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,07048519 0,09951869 ! muscle maintenance GO:0046716 19 14 0,000 0,07048519 0,09945763 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,07048519 0,09939665 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,07048519 0,09933575 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,07048519 0,09927492 ! cell killing GO:0001906 20 14 0,000 0,07048519 0,09921416 ! cilium assembly GO:0042384 20 14 0,000 0,07048519 0,09915348 ! peptide hormone secretion GO:0030072 23 14 0,000 0,07048519 0,09909287 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,0710063 0,0997645 ! transcription initiation GO:0006352 118 85 1,000 0,07247851 0,1017708 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,07247851 0,10170871 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,07532752 0,10564226 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,07532752 0,10557788 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,07532752 0,10551358 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,07532752 0,10544936 ! skin development GO:0043588 25 15 0,000 0,07532752 0,10538522 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,07532752 0,10532116 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,07532752 0,10525717 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,07532752 0,10519326 ! bile acid metabolic process GO:0008206 22 15 0,000 0,07532752 0,10512943 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,07532752 0,10506568 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,07532752 0,105002 ! adult walking behavior GO:0007628 25 15 0,000 0,07532752 0,1049384 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,07532752 0,10487488 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,07532752 0,10481143 ! myoblast differentiation GO:0045445 27 15 0,000 0,07532752 0,10474807 ! centrosome cycle GO:0007098 16 15 0,000 0,07532752 0,10468477 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,07532752 0,10462156 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,07532752 0,10455842 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,07532752 0,10449536 ! cerebral cortex development GO:0021987 29 15 0,000 0,07532752 0,10443237 ! response to osmotic stress GO:0006970 22 15 0,000 0,07532752 0,10436946 ! vesicle coating GO:0006901 25 15 0,000 0,07532752 0,10430662 ! DNA integration GO:0015074 22 15 0,000 0,07532752 0,10424386 ! peptide secretion GO:0002790 27 15 0,000 0,07532752 0,10418118 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,07532752 0,10411857 ! regulation of vasodilation GO:0042312 24 15 0,000 0,07532752 0,10405604 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,07532752 0,10399358 ! neuron recognition GO:0008038 22 15 0,000 0,07532752 0,10393119 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,07532752 0,10386889 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,07532752 0,10380665 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,07532752 0,10374449 ! biomineral formation GO:0031214 18 15 0,000 0,07532752 0,10368241 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,07532752 0,1036204 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,07532752 0,10355846 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,07532752 0,1034966 ! organic cation transport GO:0015695 19 15 0,000 0,07532752 0,10343481 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,07532752 0,10337309 GO:0033014|tetrapyrrole biosynthetic process, ! peptide hormone processing GO:0016486 19 15 0,000 0,07532752 0,10331145 ! female pregnancy GO:0007565 130 87 1,000 0,07545252 0,10342121 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,07695403 0,10541648 ! protein processing GO:0016485 114 88 1,000 0,07695403 0,10535373 ! protein secretion GO:0009306 27 16 0,000 0,0801449 0,10965692 ! hormone secretion GO:0046879 25 16 0,000 0,0801449 0,10959172 ! bone remodeling GO:0046849 24 16 0,000 0,0801449 0,10952661 ! endothelial cell migration GO:0043542 22 16 0,000 0,0801449 0,10946157 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,0801449 0,1093966 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0801449 0,10933172 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,0801449 0,10926691 ! glial cell development GO:0021782 24 16 0,000 0,0801449 0,10920218 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,0801449 0,10913752 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,0801449 0,10907295 ! protein polyubiquitination GO:0000209 26 16 0,000 0,0801449 0,10900844 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,0801449 0,10894402 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,0801449 0,10887967 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,0801449 0,10881539 ! fructose metabolic process GO:0006000 20 16 0,000 0,0801449 0,1087512 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,0801449 0,10868707 ! protein export from nucleus GO:0006611 24 16 0,000 0,0801449 0,10862303 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,0801449 0,10855906 ! DNA replication initiation GO:0006270 25 16 0,000 0,0801449 0,10849516 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,0801449 0,10843134 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,0801449 0,10836759 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,0801449 0,10830392 ! diencephalon development GO:0021536 25 16 0,000 0,0801449 0,10824033 ! neural crest cell migration GO:0001755 24 16 0,000 0,0801449 0,10817681 ! G1 phase GO:0051318 27 16 0,000 0,0801449 0,10811336 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,0801449 0,10804999 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,0801449 0,10798669 ! steroid catabolic process GO:0006706 22 16 0,000 0,0801449 0,10792346 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,0801449 0,10786031 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,0801449 0,10779724 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,0801449 0,10773424 ! sperm-egg recognition GO:0035036 16 16 0,000 0,0801449 0,10767131 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,0801449 0,10760845 ! nerve development GO:0021675 18 16 0,000 0,0801449 0,10754567 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,0801449 0,10748296 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,0801449 0,10742033 ! negative regulation of translation GO:0017148 22 16 0,000 0,0801449 0,10735776 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,08305358 0,11118932 ! cell fate commitment GO:0045165 141 92 1,000 0,08305358 0,11112463 ! positive regulation of immune response GO:0050778 121 92 1,000 0,08305358 0,11106003 ! sulfur metabolic process GO:0006790 118 92 1,000 0,08305358 0,11099549 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,08460118 0,11299809 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,08460118 0,1129325 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,08493746 0,11331564 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,08493746 0,11324995 ! negative regulation of defense response GO:0031348 19 17 0,000 0,08493746 0,11318433 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,08493746 0,1131188 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,08493746 0,11305333 ! glycerol metabolic process GO:0006071 20 17 0,000 0,08493746 0,11298795 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,08493746 0,11292264 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,08493746 0,1128574 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,08493746 0,11279224 ! signal complex assembly GO:0007172 29 17 0,000 0,08493746 0,11272716 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,08493746 0,11266215 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,08493746 0,11259721 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,08493746 0,11253235 ! keratinization GO:0031424 17 17 0,000 0,08493746 0,11246757 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,08493746 0,11240285 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,08493746 0,11233822 ! retinoid metabolic process GO:0001523 22 17 0,000 0,08493746 0,11227366 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,08493746 0,11220917 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,08493746 0,11214475 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,08493746 0,11208041 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,08493746 0,11201615 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,08493746 0,11195195 ! membrane budding GO:0006900 29 17 0,000 0,08493746 0,11188784 ! heme metabolic process GO:0042168 27 17 0,000 0,08493746 0,11182379 ! body fluid secretion GO:0007589 27 17 0,000 0,08493746 0,11175982 ! stem cell differentiation GO:0048863 36 17 0,000 0,08493746 0,11169592 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,08493746 0,11163209 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,08493746 0,11156834 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,08493746 0,11150466 ! sensory perception of pain GO:0019233 23 17 0,000 0,08493746 0,11144105 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,08493746 0,11137751 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,08493746 0,11131405 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,08493746 0,11125066 ! synaptogenesis GO:0007416 24 17 0,000 0,08493746 0,11118734 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,08493746 0,1111241 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,08493746 0,11106092 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,08493746 0,11099782 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,08493746 0,11093479 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,08493746 0,11087183 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,08493746 0,11080894 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,08493746 0,11074612 ! response to oxidative stress GO:0006979 141 94 1,000 0,08615758 0,11227334 ! protein maturation GO:0051604 129 96 1,000 0,08929632 0,11629758 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,08970532 0,11676414 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,08970532 0,1166981 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,08970532 0,11663213 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,08970532 0,11656624 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,08970532 0,11650042 ! cAMP metabolic process GO:0046058 33 18 0,000 0,08970532 0,11643467 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,08970532 0,116369 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,08970532 0,11630341 ! axis specification GO:0009798 26 18 0,000 0,08970532 0,11623788 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,08970532 0,11617243 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,08970532 0,11610706 ! pancreas development GO:0031016 26 18 0,000 0,08970532 0,11604176 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,08970532 0,11597653 ! glutamine metabolic process GO:0006541 23 18 0,000 0,08970532 0,11591137 ! response to retinoic acid GO:0032526 25 18 0,000 0,08970532 0,11584629 ! central nervous system neuron development GO:0021954 30 18 0,000 0,08970532 0,11578128 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,08970532 0,11571634 ! fucose metabolic process GO:0006004 26 18 0,000 0,08970532 0,11565148 ! response to fungus GO:0009620 19 18 0,000 0,08970532 0,11558669 ! peptide cross-linking GO:0018149 31 18 0,000 0,08970532 0,11552197 ! heart process GO:0003015 27 18 0,000 0,08970532 0,11545733 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,08970532 0,11539275 GO:0006692|prostanoid metabolic process, ! synaptic vesicle transport GO:0048489 33 18 0,000 0,08970532 0,11532825 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,08970532 0,11526382 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,08970532 0,11519946 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,08970532 0,11513518 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,08970532 0,11507097 ! vitamin transport GO:0051180 24 18 0,000 0,08970532 0,11500682 ! hormone transport GO:0009914 27 18 0,000 0,08970532 0,11494275 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,08970532 0,11487875 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,08970532 0,11481483 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,08970532 0,11475097 ! cell-cell recognition GO:0009988 20 18 0,000 0,08970532 0,11468718 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,08970532 0,11462347 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,08970532 0,11455982 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,08970532 0,11449625 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,08970532 0,11443275 ! calcium ion transport GO:0006816 167 99 1,000 0,09406728 0,11993057 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,09444861 0,12035003 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,09444861 0,12028339 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,09444861 0,12021683 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,09444861 0,12015034 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,09444861 0,12008392 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,09444861 0,12001757 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,09444861 0,1199513 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,09444861 0,1198851 ! sensory perception of taste GO:0050909 23 19 0,000 0,09444861 0,11981898 ! smooth muscle contraction GO:0006939 36 19 0,000 0,09444861 0,11975293 ! peroxisome organization GO:0007031 29 19 0,000 0,09444861 0,11968695 ! digestive system process GO:0022600 30 19 0,000 0,09444861 0,11962104 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,09444861 0,11955521 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,09444861 0,11948944 ! response to vitamin A GO:0033189 26 19 0,000 0,09444861 0,11942375 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,09444861 0,11935814 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,09444861 0,11929259 ! response to starvation GO:0042594 30 19 0,000 0,09444861 0,11922712 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,09444861 0,11916172 ! cytolysis GO:0019835 20 19 0,000 0,09444861 0,11909639 ! vasodilation GO:0042311 33 19 0,000 0,09444861 0,11903113 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,09444861 0,11896594 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,09444861 0,11890083 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,09444861 0,11883578 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,09444861 0,11877081 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,09444861 0,11870591 ! sarcomere organization GO:0045214 23 19 0,000 0,09444861 0,11864107 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,09444861 0,11857631 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,09444861 0,11851162 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,09444861 0,11844701 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,09444861 0,11838246 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,09444861 0,11831798 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,09444861 0,11825357 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,09444861 0,11818923 ! protein stabilization GO:0050821 26 19 0,000 0,09444861 0,11812496 ! regulation of translation GO:0006417 151 100 1,000 0,09567386 0,11959232 ! divalent metal ion transport GO:0070838 171 100 1,000 0,09567386 0,11952736 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,09567386 0,11946247 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,09916746 0,12375754 ! iron ion transport GO:0006826 37 20 0,000 0,09916746 0,12369043 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,09916746 0,12362339 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,09916746 0,12355642 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,09916746 0,12348952 ! response to vitamin GO:0033273 29 20 0,000 0,09916746 0,1234227 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,09916746 0,12335595 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,09916746 0,12328927 ! spinal cord development GO:0021510 31 20 0,000 0,09916746 0,12322266 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,09916746 0,12315613 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,09916746 0,12308966 ! chromosome condensation GO:0030261 31 20 0,000 0,09916746 0,12302327 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,09916746 0,12295695 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,09916746 0,12289071 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,09916746 0,12282453 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,09916746 0,12275842 ! DNA modification GO:0006304 28 20 0,000 0,09916746 0,12269239 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,09916746 0,12262642 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,09916746 0,12256053 ! collagen catabolic process GO:0030574 25 20 0,000 0,09916746 0,12249471 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,09916746 0,12242896 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,09916746 0,12236328 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,09916746 0,12229767 ! alditol metabolic process GO:0019400 24 20 0,000 0,09916746 0,12223213 ! actin filament-based movement GO:0030048 34 20 0,000 0,09916746 0,12216666 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,10386198 0,12788145 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,10386198 0,12781303 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,10386198 0,12774468 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,10386198 0,1276764 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,10386198 0,1276082 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,10386198 0,12754007 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,10386198 0,12747201 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,10386198 0,12740403 ! vesicle docking GO:0048278 27 21 0,000 0,10386198 0,12733612 ! phototransduction GO:0007602 25 21 0,000 0,10386198 0,12726828 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,10386198 0,12720051 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,10386198 0,12713281 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,10386198 0,12706519 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,10386198 0,12699764 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,10386198 0,12693016 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,10386198 0,12686275 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,10386198 0,12679541 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,10386198 0,12672814 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,10386198 0,12666095 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,10386198 0,12659383 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,10386198 0,12652678 ! fatty acid transport GO:0015908 30 21 0,000 0,10386198 0,12645979 ! immunoglobulin production GO:0002377 33 21 0,000 0,10386198 0,12639288 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,10386198 0,12632605 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,10386198 0,12625928 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,10386198 0,12619258 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,10386198 0,12612595 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,10386198 0,12605939 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,10386198 0,12599291 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,10386198 0,12592649 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,10386198 0,12586014 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,10386198 0,12579387 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,10386198 0,12572766 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,10386198 0,12566152 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,10853231 0,13124306 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,10853231 0,13117409 ! viral genome replication GO:0019079 29 22 0,000 0,10853231 0,1311052 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,10853231 0,13103638 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,10853231 0,13096763 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,10853231 0,13089895 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,10853231 0,13083035 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,10853231 0,13076181 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,10853231 0,13069335 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,10853231 0,13062496 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,10853231 0,13055664 ! lysosome organization GO:0007040 37 22 0,000 0,10853231 0,1304884 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,10853231 0,13042022 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,10853231 0,13035212 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,10853231 0,13028408 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,10853231 0,13021612 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,10853231 0,13014823 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,10853231 0,13008041 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,10853231 0,13001266 ! blastocyst development GO:0001824 37 22 0,000 0,10853231 0,12994498 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,10853231 0,12987737 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,11317856 0,13536697 ! neuron fate commitment GO:0048663 32 23 0,000 0,11317856 0,13529661 ! embryonic pattern specification GO:0009880 31 23 0,000 0,11317856 0,13522633 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,11317856 0,13515612 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,11317856 0,13508598 ! vesicle targeting GO:0006903 32 23 0,000 0,11317856 0,13501591 ! osteoblast differentiation GO:0001649 40 23 0,000 0,11317856 0,13494592 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,11317856 0,134876 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,11317856 0,13480615 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,11317856 0,13473638 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,11317856 0,13466667 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,11317856 0,13459704 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,11317856 0,13452748 ! cell fate determination GO:0001709 45 23 0,000 0,11317856 0,134458 ! pentose metabolic process GO:0019321 31 23 0,000 0,11317856 0,13438858 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,11317856 0,13431924 ! spermatid development GO:0007286 33 23 0,000 0,11317856 0,13424996 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,11317856 0,13418076 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,11317856 0,13411163 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,11317856 0,13404258 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,11317856 0,13397359 ! telomere organization GO:0032200 32 23 0,000 0,11317856 0,13390467 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,11317856 0,13383583 ! regulation of amine transport GO:0051952 38 23 0,000 0,11317856 0,13376705 ! liver development GO:0001889 40 23 0,000 0,11317856 0,13369835 ! initiation of viral infection GO:0019059 42 24 0,000 0,11780086 0,13908726 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,11780086 0,13901589 ! superoxide metabolic process GO:0006801 32 24 0,000 0,11780086 0,1389446 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,11780086 0,13887338 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,11780086 0,13880224 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,11780086 0,13873117 ! sperm motility GO:0030317 27 24 0,000 0,11780086 0,13866017 ! vacuole organization GO:0007033 39 24 0,000 0,11780086 0,13858924 ! receptor metabolic process GO:0043112 37 24 0,000 0,11780086 0,13851839 ! neural crest cell development GO:0014032 39 24 0,000 0,11780086 0,13844761 GO:0014033|neural crest cell differentiation, ! base-excision repair GO:0006284 31 24 0,000 0,11780086 0,1383769 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,11780086 0,13830627 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,11780086 0,1382357 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,11780086 0,13816521 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,11780086 0,13809479 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,12239933 0,14341236 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,12239933 0,14333934 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,12239933 0,14326639 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,12239933 0,14319352 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,12239933 0,14312072 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,12239933 0,143048 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,12239933 0,14297535 ! peptide transport GO:0015833 43 25 0,000 0,12239933 0,14290277 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,12239933 0,14283027 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,12239933 0,14275784 ! phospholipid transport GO:0015914 35 25 0,000 0,12239933 0,14268548 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,12239933 0,1426132 ! detection of light stimulus GO:0009583 30 25 0,000 0,12239933 0,14254099 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,12239933 0,14246886 GO:0045840|positive regulation of mitosis, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,12697409 0,14771898 ! translational initiation GO:0006413 43 26 0,000 0,12697409 0,1476443 ! regulation of pH GO:0006885 36 26 0,000 0,12697409 0,14756969 ! circadian rhythm GO:0007623 42 26 0,000 0,12697409 0,14749516 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,12697409 0,14742071 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,12697409 0,14734633 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,12697409 0,14727202 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,12697409 0,14719779 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,12697409 0,14712364 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,12697409 0,14704956 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,12697409 0,14697555 ! regulation of coagulation GO:0050818 39 26 0,000 0,12697409 0,14690162 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,13152527 0,15209056 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,13152527 0,15201413 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,13152527 0,15193778 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,13152527 0,15186151 ! membrane docking GO:0022406 39 27 0,000 0,13152527 0,15178531 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,13152527 0,15170919 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,13152527 0,15163315 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,13152527 0,15155718 ! myofibril assembly GO:0030239 36 27 0,000 0,13152527 0,15148128 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,13152527 0,15140547 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,13152527 0,15132973 ! natural killer cell activation GO:0030101 35 27 0,000 0,13152527 0,15125406 ! lipid oxidation GO:0034440 38 27 0,000 0,13152527 0,15117847 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,13152527 0,15110296 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,13152527 0,15102752 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,13152527 0,15095216 ! gene silencing GO:0016458 41 27 0,000 0,13152527 0,15087687 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,13605298 0,15599295 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,13605298 0,15591523 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,13605298 0,15583758 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,13605298 0,15576001 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,13605298 0,15568252 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,13605298 0,1556051 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,13605298 0,15552776 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,13605298 0,1554505 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,13605298 0,15537332 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,13605298 0,15529621 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,13605298 0,15521918 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,13605298 0,15514222 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,13605298 0,15506534 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,13605298 0,15498854 ! mesoderm formation GO:0001707 46 28 0,000 0,13605298 0,15491181 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,13605298 0,15483516 ! BMP signaling pathway GO:0030509 40 28 0,000 0,13605298 0,15475859 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,13605298 0,15468209 ! placenta development GO:0001890 37 28 0,000 0,13605298 0,15460566 ! regulation of innate immune response GO:0045088 38 29 0,000 0,14055735 0,15964538 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,14055735 0,15956658 ! protein targeting to membrane GO:0006612 53 29 0,000 0,14055735 0,15948786 ! mismatch repair GO:0006298 34 29 0,000 0,14055735 0,15940922 ! muscle cell development GO:0055001 38 29 0,000 0,14055735 0,15933066 ! formation of primary germ layer GO:0001704 48 29 0,000 0,14055735 0,15925217 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,14055735 0,15917376 ! eye morphogenesis GO:0048592 51 29 0,000 0,14055735 0,15909542 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,14055735 0,15901717 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,14503848 0,16400615 ! collagen metabolic process GO:0032963 40 30 0,000 0,14503848 0,16392556 ! organic anion transport GO:0015711 51 30 0,000 0,14503848 0,16384505 ! cholesterol transport GO:0030301 46 30 0,000 0,14503848 0,16376461 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,14503848 0,16368426 ! spindle organization GO:0007051 37 30 0,000 0,14503848 0,16360398 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,14503848 0,16352378 ! ceramide metabolic process GO:0006672 43 30 0,000 0,14503848 0,16344366 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,14503848 0,16336362 ! adult locomotory behavior GO:0008344 47 30 0,000 0,14503848 0,16328366 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,14503848 0,16320377 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,14503848 0,16312397 ! negative regulation of secretion GO:0051048 49 31 0,000 0,14949651 0,16805571 ! glial cell differentiation GO:0010001 55 31 0,000 0,14949651 0,16797361 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,14949651 0,16789159 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,14949651 0,16780965 ! odontogenesis GO:0042476 50 31 0,000 0,14949651 0,16772779 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,14949651 0,16764602 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,14949651 0,16756432 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,14949651 0,1674827 ! cell fate specification GO:0001708 37 31 0,000 0,14949651 0,16740116 ! RNA modification GO:0009451 40 31 0,000 0,14949651 0,1673197 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,15393155 0,17219969 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,15393155 0,17211598 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,15393155 0,17203234 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,15393155 0,17194879 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,15393155 0,17186532 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,15393155 0,17178193 ! cytokine production GO:0001816 44 32 0,000 0,15393155 0,17169862 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,15393155 0,1716154 ! vesicle localization GO:0051648 47 32 0,000 0,15393155 0,17153225 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,15834371 0,17636345 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,15834371 0,17627809 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,15834371 0,17619281 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,15834371 0,17610761 ! sister chromatid segregation GO:0000819 46 33 0,000 0,15834371 0,17602249 ! actomyosin structure organization GO:0031032 43 33 0,000 0,15834371 0,17593746 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,15834371 0,1758525 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,15834371 0,17576763 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,15834371 0,17568284 ! lipid homeostasis GO:0055088 55 33 0,000 0,15834371 0,17559814 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,15834371 0,17551351 ! regulation of proteolysis GO:0030162 50 33 0,000 0,15834371 0,17542897 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,15834371 0,1753445 ! cytokinesis GO:0000910 52 33 0,000 0,15834371 0,17526012 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,15834371 0,17517582 ! mRNA catabolic process GO:0006402 48 34 0,000 0,16273312 0,17994527 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,16273312 0,1798588 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,16273312 0,17977241 ! feeding behavior GO:0007631 45 34 0,000 0,16273312 0,17968611 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,16273312 0,17959989 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,16273312 0,17951375 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,16273312 0,17942769 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,16273312 0,17934172 ! polyol metabolic process GO:0019751 44 34 0,000 0,16273312 0,17925583 ! aerobic respiration GO:0009060 47 34 0,000 0,16273312 0,17917002 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,16273312 0,17908429 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,16709988 0,18380187 ! Notch signaling pathway GO:0007219 56 35 0,000 0,16709988 0,18371402 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,16709988 0,18362624 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,16709988 0,18353855 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,16709988 0,18345094 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,16709988 0,18336342 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,16709988 0,18327598 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,16709988 0,18318862 ! protein homooligomerization GO:0051260 52 35 0,000 0,16709988 0,18310134 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,17144412 0,18777213 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,17144412 0,18768275 ! organic ether metabolic process GO:0018904 46 36 0,000 0,17144412 0,18759347 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,17144412 0,18750426 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,17144412 0,18741515 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,17144412 0,18732611 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,17576594 0,19195711 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,17576594 0,191866 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,17576594 0,19177498 ! ion transmembrane transport GO:0034220 56 37 0,000 0,17576594 0,19168405 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,17576594 0,19159321 ! regulation of protein secretion GO:0050708 51 37 0,000 0,17576594 0,19150245 ! amino acid activation GO:0043038 52 37 0,000 0,17576594 0,19141177 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,17576594 0,19132119 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,18006547 0,19590851 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,18006547 0,19581588 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,18006547 0,19572334 ! phagocytosis GO:0006909 60 38 0,000 0,18006547 0,19563089 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,18434282 0,20018342 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,18434282 0,20008895 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,18434282 0,19999457 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,18434282 0,19990028 ! JNK cascade GO:0007254 54 39 0,000 0,18434282 0,19980607 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,1885981 0,20432201 ! response to calcium ion GO:0051592 58 40 0,000 0,1885981 0,20422581 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,1885981 0,2041297 ! regulation of tube size GO:0035150 60 40 0,000 0,1885981 0,20403369 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,1885981 0,20393776 ! inner ear development GO:0048839 57 40 0,000 0,1885981 0,20384193 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,1885981 0,20374618 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,1885981 0,20365053 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,1885981 0,20355496 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,1885981 0,20345949 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,1885981 0,2033641 ! endosome transport GO:0016197 71 41 0,000 0,19283142 0,20783142 ! striated muscle contraction GO:0006941 62 41 0,000 0,19283142 0,20773408 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,19283142 0,20763683 ! biopolymer methylation GO:0043414 62 41 0,000 0,19283142 0,20753966 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,19283142 0,20744259 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,19704289 0,21187408 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,19704289 0,21177507 ! excretion GO:0007588 63 42 0,000 0,19704289 0,21167616 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,19704289 0,21157734 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,19704289 0,21147861 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,19704289 0,21137997 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,20123263 0,21577392 ! tRNA processing GO:0008033 49 43 0,000 0,20123263 0,21567337 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,20123263 0,21557292 ! methylation GO:0032259 64 43 0,000 0,20123263 0,21547256 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,20540075 0,21983329 ! glycolysis GO:0006096 53 44 0,000 0,20540075 0,21973104 ! regulation of ion transport GO:0043269 57 44 0,000 0,20540075 0,21962889 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,20540075 0,21952683 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,20540075 0,21942486 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,20540075 0,219323 ! RNA catabolic process GO:0006401 64 45 0,000 0,20954736 0,22364683 ! regulation of translational initiation GO:0006446 64 45 0,000 0,20954736 0,2235431 ! cell recognition GO:0008037 58 45 0,000 0,20954736 0,22343947 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,21367256 0,22773258 ! cell redox homeostasis GO:0045454 63 46 0,000 0,21367256 0,2276271 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,21367256 0,22752171 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,21367256 0,22741643 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,21777648 0,2316771 ! viral infectious cycle GO:0019058 71 47 0,000 0,21777648 0,23156999 ! endocrine system development GO:0035270 83 47 0,000 0,21777648 0,23146298 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,21777648 0,23135607 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,21777648 0,23124926 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,21777648 0,23114255 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,21777648 0,23103593 ! chloride transport GO:0006821 67 48 0,000 0,2218592 0,23525872 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,2218592 0,23515031 ! gastrulation GO:0007369 73 48 0,000 0,2218592 0,23504199 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,2218592 0,23493378 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,2218592 0,23482566 ! regulation of endocytosis GO:0030100 63 48 0,000 0,2218592 0,23471765 ! nuclear export GO:0051168 69 48 0,000 0,2218592 0,23460973 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,22592085 0,23879502 ! sensory perception of smell GO:0007608 61 49 0,000 0,22592085 0,23868533 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,22592085 0,23857574 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,22592085 0,23846625 ! RNA elongation GO:0006354 62 49 0,000 0,22592085 0,23835686 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,22592085 0,23824758 ! regulation of actin filament length GO:0030832 72 50 0,000 0,22996153 0,24239758 ! proton transport GO:0015992 75 50 0,000 0,22996153 0,24228655 ! positive regulation of secretion GO:0051047 71 51 0,000 0,23398135 0,24640894 ! hydrogen transport GO:0006818 77 51 0,000 0,23398135 0,24629616 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,23398135 0,24618349 ! adult behavior GO:0030534 80 51 0,000 0,23398135 0,24607093 ! transition metal ion transport GO:0000041 74 52 0,000 0,23798042 0,25016223 ! regulation of cellular component size GO:0032535 74 52 0,000 0,23798042 0,25004795 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,23798042 0,24993377 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,23798042 0,2498197 ! establishment of organelle localization GO:0051656 85 52 0,000 0,23798042 0,24970573 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,24195883 0,2537644 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,24195883 0,25364873 ! cell projection assembly GO:0030031 76 53 0,000 0,24195883 0,25353318 ! amino acid transport GO:0006865 84 54 0,000 0,24591671 0,25756304 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,24591671 0,2574458 ! regulation of mitosis GO:0007088 84 54 0,000 0,24591671 0,25732867 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,24591671 0,25721165 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,24591671 0,25709474 ! exocytosis GO:0006887 74 55 0,000 0,24985414 0,26109247 ! mesoderm development GO:0007498 76 55 0,000 0,24985414 0,2609739 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,24985414 0,26085543 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,24985414 0,26073708 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,25377124 0,26470469 ! chromosome segregation GO:0007059 83 57 0,000 0,25766811 0,26864762 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,25766811 0,26852589 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,25766811 0,26840428 ! camera-type eye development GO:0043010 88 57 0,000 0,25766811 0,26828277 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,26154485 0,27219599 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,26540156 0,27608485 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,26923836 0,27994947 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,26923836 0,27982296 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,26923836 0,27969658 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,26923836 0,2795703 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,27305533 0,2834058 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,27305533 0,28327797 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,27685258 0,28708789 ! neurotransmitter transport GO:0006836 81 62 0,000 0,27685258 0,28695851 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,27685258 0,28682925 ! organelle localization GO:0051640 96 62 0,000 0,27685258 0,28670011 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,28063022 0,29048132 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,28438834 0,29423894 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,28438834 0,29410664 ! hexose catabolic process GO:0019320 82 64 0,000 0,28438834 0,29397446 ! activation of immune response GO:0002253 83 65 0,000 0,28812704 0,29770538 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,29184642 0,301413 ! antigen processing and presentation GO:0019882 96 66 0,000 0,29184642 0,30127772 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,29184642 0,30114256 ! regulation of immune effector process GO:0002697 101 66 0,000 0,29184642 0,30100751 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,29554658 0,30468719 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,29922761 0,30834387 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,29922761 0,30820578 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,29922761 0,30806782 ! inorganic anion transport GO:0015698 93 68 0,000 0,29922761 0,30792998 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,30288962 0,3115591 ! amine transport GO:0015837 101 70 0,000 0,30653271 0,3151655 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,30653271 0,31502468 ! muscle cell differentiation GO:0042692 104 71 0,000 0,31015696 0,31860698 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,31015696 0,31846474 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,31015696 0,31832263 ! regulation of blood pressure GO:0008217 107 73 0,000 0,31734937 0,32555912 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,31734937 0,32541397 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,32091771 0,32892635 ! digestion GO:0007586 97 74 0,000 0,32091771 0,32877983 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,3244676 0,33226869 ! tRNA metabolic process GO:0006399 95 76 0,000 0,32799913 0,33573565 ! response to unfolded protein GO:0006986 99 76 0,000 0,32799913 0,3355863 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,33151241 0,33903003 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,33151241 0,33887935 ! protein ubiquitination GO:0016567 125 77 0,000 0,33151241 0,3387288 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,33151241 0,33857839 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,33151241 0,33842811 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,33500752 0,3418444 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,33500752 0,34169281 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,33848455 0,3450862 ! cellular respiration GO:0045333 107 79 0,000 0,33848455 0,3449333 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,33848455 0,34478054 ! regulation of lyase activity GO:0051339 133 79 0,000 0,33848455 0,34462792 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,33848455 0,34447543 ! chromatin assembly GO:0031497 102 80 0,000 0,34194361 0,34784179 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,34194361 0,34768802 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,34194361 0,34753438 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,34538477 0,35087675 ! mRNA transport GO:0051028 121 81 0,000 0,34538477 0,35072184 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,34538477 0,35056706 ! vitamin metabolic process GO:0006766 103 81 0,000 0,34538477 0,35041243 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,35221379 0,3571833 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,35560184 0,36046021 ! sterol metabolic process GO:0016125 120 84 0,000 0,35560184 0,36030142 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,35897235 0,36355632 ! rRNA metabolic process GO:0016072 107 85 0,000 0,35897235 0,36339631 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,36232543 0,36662934 ! nucleosome organization GO:0034728 114 87 0,000 0,36566116 0,36984198 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,36566116 0,36967942 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,36566116 0,36951699 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,36897963 0,3727067 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,36897963 0,37254309 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,36897963 0,37237962 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,37228094 0,37554656 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,37228094 0,37538192 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,37556516 0,37852755 ! hormone metabolic process GO:0042445 121 90 0,000 0,37556516 0,37836174 ! RNA localization GO:0006403 135 91 0,000 0,37883238 0,3814862 ! ATP metabolic process GO:0046034 137 91 0,000 0,37883238 0,38131925 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,3820827 0,38442266 ! DNA recombination GO:0006310 146 92 0,000 0,3820827 0,38425457 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,38531619 0,38733708 ! electron transport chain GO:0022900 123 94 0,000 0,38853295 0,39040008 ! carboxylic acid transport GO:0046942 147 95 0,000 0,39173306 0,39344369 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,39491661 0,396468 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,39491661 0,39629502 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,39491661 0,3961222 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,39491661 0,39594952 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,39808367 0,39895096 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,39808367 0,3987772 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,40748683 0,40801903 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,40748683 0,40784147 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,40748683 0,40766407 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,40748683 0,40748683