pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6422-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 224 98 8,000 8,346E-09 2,039E-05 ! cartilage development GO:0051216 99 53 6,000 3,067E-08 3,747E-05 ! negative regulation of protein kinase activity GO:0006469 144 69 6,000 1,98E-07 1,612E-04 ! negative regulation of kinase activity GO:0033673 145 70 6,000 2,188E-07 1,337E-04 ! negative regulation of phosphorylation GO:0042326 52 24 4,000 2,856E-07 1,396E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 5,000 2,892E-07 1,178E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 5,000 2,892E-07 1,009E-04 ! negative regulation of transferase activity GO:0051348 155 74 6,000 3,219E-07 9,831E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 3,31E-07 8,984E-05 ! chondrocyte differentiation GO:0002062 27 11 3,000 4,003E-07 9,78E-05 ! thymus development GO:0048538 29 11 3,000 4,003E-07 8,891E-05 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 4,000 4,377E-07 8,912E-05 GO:0045936|negative regulation of phosphate metabolic process, ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 4,000 7,788E-07 1,464E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 1,214E-06 2,118E-04 ! peptidyl-threonine phosphorylation GO:0018107 20 5 2,000 2,103E-06 3,425E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 5,000 3,777E-06 5,767E-04 ! neural nucleus development GO:0048857 19 6 2,000 4,188E-06 6,018E-04 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 3,000 4,528E-06 6,146E-04 ! positive regulation of protein ubiquitination GO:0031398 14 7 2,000 7,296E-06 9,381E-04 ! N-terminal protein amino acid acetylation GO:0006474 14 7 2,000 7,296E-06 8,912E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 7,296E-06 8,488E-04 ! peptidyl-threonine modification GO:0018210 26 7 2,000 7,296E-06 8,102E-04 ! glycolysis GO:0006096 71 46 4,000 8,275E-06 8,789E-04 ! cell growth GO:0016049 90 46 4,000 8,275E-06 8,423E-04 ! positive regulation of phosphorylation GO:0042327 149 81 5,000 9,633E-06 9,413E-04 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 5,000 1,109E-05 1,042E-03 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,162E-05 1,052E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,162E-05 1,014E-03 ! dendrite morphogenesis GO:0048813 14 8 2,000 1,162E-05 9,791E-04 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 3,000 1,437E-05 1,17E-03 ! vasculogenesis GO:0001570 49 25 3,000 1,437E-05 1,132E-03 ! axon extension GO:0048675 16 9 2,000 1,736E-05 1,325E-03 ! induction of positive chemotaxis GO:0050930 17 9 2,000 1,736E-05 1,285E-03 ! regulation of telomere maintenance GO:0032204 17 9 2,000 1,736E-05 1,247E-03 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 1,975E-05 1,378E-03 ! regulation of chromosome organization GO:0033044 49 27 3,000 1,975E-05 1,34E-03 ! glucose catabolic process GO:0006007 88 56 4,000 2,196E-05 1,45E-03 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 2,000 2,468E-05 1,587E-03 ! central nervous system neuron axonogenesis GO:0021955 23 10 2,000 2,468E-05 1,546E-03 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of gliogenesis GO:0014013 23 10 2,000 2,468E-05 1,508E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 2,468E-05 1,471E-03 ! protein sumoylation GO:0016925 17 10 2,000 2,468E-05 1,436E-03 ! positive regulation of cell migration GO:0030335 137 58 4,000 2,609E-05 1,482E-03 ! forebrain development GO:0030900 210 98 5,000 2,871E-05 1,594E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 2,000 3,379E-05 1,834E-03 ! negative regulation of glucose import GO:0046325 18 11 2,000 3,379E-05 1,795E-03 GO:0010829|negative regulation of glucose transport, ! regulation of embryonic development GO:0045995 35 11 2,000 3,379E-05 1,756E-03 ! skeletal system morphogenesis GO:0048705 118 63 4,000 3,907E-05 1,988E-03 ! spindle organization GO:0007051 50 32 3,000 3,952E-05 1,97E-03 ! metanephros development GO:0001656 81 32 3,000 3,952E-05 1,931E-03 ! response to peptide hormone stimulus GO:0043434 129 64 4,000 4,217E-05 2,02E-03 ! regulation of positive chemotaxis GO:0050926 22 12 2,000 4,486E-05 2,107E-03 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 37 12 2,000 4,486E-05 2,068E-03 ! histone acetylation GO:0016573 27 12 2,000 4,486E-05 2,029E-03 ! peptidyl-lysine modification GO:0018205 21 12 2,000 4,486E-05 1,992E-03 ! T cell homeostasis GO:0043029 28 12 2,000 4,486E-05 1,957E-03 ! positive regulation of cell motion GO:0051272 157 65 4,000 4,546E-05 1,949E-03 ! ear development GO:0043583 114 66 4,000 4,895E-05 2,062E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 3,000 5,049E-05 2,091E-03 ! hexose catabolic process GO:0019320 113 68 4,000 5,655E-05 2,302E-03 ! urogenital system development GO:0001655 149 69 4,000 6,067E-05 2,43E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 7,356E-05 2,899E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 2,000 7,356E-05 2,853E-03 GO:0060675|ureteric bud morphogenesis, ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 7,356E-05 2,808E-03 ! embryonic skeletal system morphogenesis GO:0048704 68 38 3,000 7,888E-05 2,964E-03 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 7,888E-05 2,92E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 4,000 8,488E-05 3,095E-03 ! N-terminal protein amino acid modification GO:0031365 30 15 2,000 9,155E-05 3,289E-03 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 9,155E-05 3,241E-03 ! lymphocyte homeostasis GO:0002260 33 15 2,000 9,155E-05 3,195E-03 ! monosaccharide catabolic process GO:0046365 125 77 4,000 1,026E-04 3,53E-03 ! regulation of protein ubiquitination GO:0031396 28 16 2,000 1,122E-04 3,806E-03 ! regulation of T cell differentiation GO:0045580 78 42 3,000 1,174E-04 3,928E-03 ! neutrophil chemotaxis GO:0030593 29 17 2,000 1,356E-04 4,477E-03 ! negative regulation of homeostatic process GO:0032845 36 17 2,000 1,356E-04 4,417E-03 ! branching morphogenesis of a tube GO:0048754 102 45 3,000 1,541E-04 4,953E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 1,62E-04 5,14E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 1,62E-04 5,074E-03 ! pigmentation GO:0043473 103 46 3,000 1,68E-04 5,194E-03 ! response to insulin stimulus GO:0032868 98 47 3,000 1,827E-04 5,58E-03 ! alcohol catabolic process GO:0046164 142 87 4,000 1,828E-04 5,514E-03 ! cellular pigmentation GO:0033059 37 19 2,000 1,915E-04 5,707E-03 ! positive regulation of protein modification process GO:0031401 156 90 4,000 2,143E-04 6,308E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 2,15E-04 6,254E-03 ! positive regulation of ossification GO:0045778 50 20 2,000 2,243E-04 6,448E-03 ! protein amino acid acetylation GO:0006473 41 20 2,000 2,243E-04 6,373E-03 ! response to alkaloid GO:0043279 38 20 2,000 2,243E-04 6,3E-03 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 2,243E-04 6,228E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 2,243E-04 6,158E-03 ! regulation of glucose import GO:0046324 30 20 2,000 2,243E-04 6,09E-03 GO:0010827|regulation of glucose transport, ! ossification GO:0001503 205 91 4,000 2,257E-04 6,058E-03 ! gland development GO:0048732 220 91 4,000 2,257E-04 5,993E-03 ! regulation of ossification GO:0030278 123 50 3,000 2,326E-04 6,111E-03 ! bone development GO:0060348 206 92 4,000 2,375E-04 6,172E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 2,606E-04 6,701E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 2,606E-04 6,631E-03 ! positive regulation of osteoblast differentiation GO:0045669 52 21 2,000 2,606E-04 6,563E-03 ! morphogenesis of a branching structure GO:0001763 116 52 3,000 2,709E-04 6,754E-03 ! positive regulation of bone remodeling GO:0046852 54 22 2,000 3,004E-04 7,413E-03 GO:0034105|positive regulation of tissue remodeling, ! inactivation of MAPK activity GO:0000188 45 22 2,000 3,004E-04 7,339E-03 ! central nervous system neuron development GO:0021954 47 22 2,000 3,004E-04 7,266E-03 ! ureteric bud development GO:0001657 50 22 2,000 3,004E-04 7,195E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 3,004E-04 7,125E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! response to glucocorticoid stimulus GO:0051384 42 22 2,000 3,004E-04 7,057E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 3,004E-04 6,989E-03 ! inner ear receptor cell differentiation GO:0060113 42 22 2,000 3,004E-04 6,923E-03 ! embryonic skeletal system development GO:0048706 101 54 3,000 3,135E-04 7,159E-03 ! regulation of muscle contraction GO:0006937 94 54 3,000 3,135E-04 7,093E-03 ! response to UV GO:0009411 120 55 3,000 3,366E-04 7,543E-03 ! regulation of chemotaxis GO:0050920 45 23 2,000 3,439E-04 7,639E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 3,439E-04 7,57E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 3,532E-04 7,704E-03 GO:0045844|positive regulation of striated muscle development, ! embryonic camera-type eye development GO:0031076 12 5 1,000 3,532E-04 7,636E-03 GO:0048596|embryonic camera-type eye morphogenesis, ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 3,532E-04 7,569E-03 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 1,000 3,532E-04 7,503E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 3,532E-04 7,439E-03 ! parathyroid gland development GO:0060017 14 5 1,000 3,532E-04 7,375E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 3,532E-04 7,313E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 3,532E-04 7,251E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 3,532E-04 7,191E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 3,532E-04 7,131E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 3,532E-04 7,073E-03 ! response to mercury ion GO:0046689 8 5 1,000 3,532E-04 7,015E-03 ! decidualization GO:0046697 11 5 1,000 3,532E-04 6,959E-03 ! B cell homeostasis GO:0001782 13 5 1,000 3,532E-04 6,903E-03 ! cellular response to nutrient GO:0031670 8 5 1,000 3,532E-04 6,848E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 3,532E-04 6,794E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 3,532E-04 6,741E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 3,532E-04 6,689E-03 ! regulation of bone remodeling GO:0046850 143 57 3,000 3,862E-04 7,257E-03 ! mechanoreceptor differentiation GO:0042490 48 24 2,000 3,913E-04 7,298E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 3,913E-04 7,243E-03 ! central nervous system neuron differentiation GO:0021953 51 24 2,000 3,913E-04 7,188E-03 ! response to corticosteroid stimulus GO:0031960 46 24 2,000 3,913E-04 7,135E-03 ! sex determination GO:0007530 48 24 2,000 3,913E-04 7,082E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 3,913E-04 7,03E-03 ! regulation of tissue remodeling GO:0034103 146 58 3,000 4,129E-04 7,362E-03 ! regulation of behavior GO:0050795 48 25 2,000 4,427E-04 7,838E-03 ! leukocyte homeostasis GO:0001776 50 25 2,000 4,427E-04 7,781E-03 ! kidney development GO:0001822 133 60 3,000 4,701E-04 8,203E-03 ! pyruvate metabolic process GO:0006090 43 26 2,000 4,983E-04 8,633E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 4,983E-04 8,573E-03 ! regulation of osteoblast differentiation GO:0045667 68 26 2,000 4,983E-04 8,513E-03 ! regulation of heart contraction GO:0008016 123 61 3,000 5,008E-04 8,495E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 5,277E-04 8,891E-03 ! activation of MAPKKK activity GO:0000185 12 6 1,000 5,277E-04 8,83E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 5,277E-04 8,77E-03 ! myeloid dendritic cell activation GO:0001773 10 6 1,000 5,277E-04 8,711E-03 GO:0043011|myeloid dendritic cell differentiation, ! triglyceride catabolic process GO:0019433 10 6 1,000 5,277E-04 8,652E-03 ! maternal placenta development GO:0001893 12 6 1,000 5,277E-04 8,595E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 1,000 5,277E-04 8,538E-03 ! regulation of smooth muscle cell differentiation GO:0051150 12 6 1,000 5,277E-04 8,482E-03 ! glutamate catabolic process GO:0006538 12 6 1,000 5,277E-04 8,426E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 5,277E-04 8,372E-03 GO:0051653|spindle localization, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 5,277E-04 8,318E-03 GO:0045686|negative regulation of glial cell differentiation, ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 5,277E-04 8,264E-03 ! regulation of homeostatic process GO:0032844 148 62 3,000 5,328E-04 8,291E-03 ! acetyl-CoA metabolic process GO:0006084 41 27 2,000 5,581E-04 8,629E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 6,012E-04 9,237E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 6,223E-04 9,502E-03 ! protein amino acid acylation GO:0043543 59 28 2,000 6,223E-04 9,443E-03 ! dendrite development GO:0016358 67 28 2,000 6,223E-04 9,385E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 6,223E-04 9,327E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 6,223E-04 9,27E-03 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 6,911E-04 0,01023216 ! response to organic cyclic substance GO:0014070 58 29 2,000 6,911E-04 0,01017052 ! negative regulation of cell growth GO:0030308 142 67 3,000 7,152E-04 0,01046223 ! prostate gland development GO:0030850 14 7 1,000 7,359E-04 0,01070103 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 7,359E-04 0,01063771 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 7,359E-04 0,01057514 ! regulation of odontogenesis GO:0042481 14 7 1,000 7,359E-04 0,01051329 ! protein-cofactor linkage GO:0018065 13 7 1,000 7,359E-04 0,01045217 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 1,000 7,359E-04 0,01039175 ! glycerol ether catabolic process GO:0044269 12 7 1,000 7,359E-04 0,01033203 GO:0046464|acylglycerol catabolic process, ! organ growth GO:0035265 15 7 1,000 7,359E-04 0,01027299 ! male sex determination GO:0030238 15 7 1,000 7,359E-04 0,01021462 ! B cell lineage commitment GO:0002326 21 7 1,000 7,359E-04 0,01015691 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 7,359E-04 0,01009985 ! T cell lineage commitment GO:0002360 16 7 1,000 7,359E-04 0,01004342 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 7,359E-04 9,988E-03 ! negative regulation of telomere maintenance GO:0032205 13 7 1,000 7,359E-04 9,932E-03 ! tissue homeostasis GO:0001894 50 30 2,000 7,645E-04 0,01026178 GO:0048871|multicellular organismal homeostasis, ! negative regulation of cell size GO:0045792 144 69 3,000 7,992E-04 0,01066855 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 3,000 7,992E-04 0,01061056 ! homeostasis of number of cells GO:0048872 131 69 3,000 7,992E-04 0,01055321 ! cell junction assembly GO:0034329 85 31 2,000 8,427E-04 0,01106803 ! male gonad development GO:0008584 56 31 2,000 8,427E-04 0,01100885 ! iron ion homeostasis GO:0055072 60 31 2,000 8,427E-04 0,01095029 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 8,427E-04 0,01089235 ! response to heat GO:0009408 54 31 2,000 8,427E-04 0,01083502 ! hindbrain development GO:0030902 65 32 2,000 9,258E-04 0,011841 ! positive regulation of catabolic process GO:0009896 72 32 2,000 9,258E-04 0,01177932 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 3,000 9,378E-04 0,01187107 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 3,000 9,378E-04 0,01180988 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 9,773E-04 0,01224393 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 9,773E-04 0,01218146 ! succinate metabolic process GO:0006105 17 8 1,000 9,773E-04 0,01211963 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 9,773E-04 0,01205842 ! glycerolipid catabolic process GO:0046503 14 8 1,000 9,773E-04 0,01199782 ! pigment granule organization GO:0048753 17 8 1,000 9,773E-04 0,01193783 ! L-phenylalanine metabolic process GO:0006558 12 8 1,000 9,773E-04 0,01187844 GO:0006559|L-phenylalanine catabolic process, ! regulation of pigmentation during development GO:0048070 25 8 1,000 9,773E-04 0,01181964 ! melanin metabolic process GO:0006582 17 8 1,000 9,773E-04 0,01176141 ! embryonic eye morphogenesis GO:0048048 16 8 1,000 9,773E-04 0,01170376 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 9,773E-04 0,01164667 ! response to UV-B GO:0010224 17 8 1,000 9,773E-04 0,01159013 ! regulation of respiratory burst GO:0060263 12 8 1,000 9,773E-04 0,01153414 ! trophectodermal cell differentiation GO:0001829 13 8 1,000 9,773E-04 0,01147868 ! leukocyte chemotaxis GO:0030595 55 33 2,000 1,014E-03 0,01185099 GO:0060326|cell chemotaxis, ! reproductive structure development GO:0048608 131 75 3,000 1,093E-03 0,01271075 ! cell-matrix adhesion GO:0007160 181 76 3,000 1,148E-03 0,0132913 ! positive regulation of ligase activity GO:0051351 130 77 3,000 1,205E-03 0,01388868 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,252E-03 0,01435499 ! regulation of epithelial cell differentiation GO:0030856 18 9 1,000 1,252E-03 0,01428791 ! neutral lipid catabolic process GO:0046461 14 9 1,000 1,252E-03 0,01422146 ! regulation of glycolysis GO:0006110 20 9 1,000 1,252E-03 0,01415562 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,252E-03 0,01409039 ! T cell selection GO:0045058 27 9 1,000 1,252E-03 0,01402575 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,252E-03 0,01396171 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 1,000 1,252E-03 0,01389824 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 1,252E-03 0,01383536 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 1,252E-03 0,01377303 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,252E-03 0,01371127 ! S phase GO:0051320 10 9 1,000 1,252E-03 0,01365006 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage differentiation GO:0045649 16 9 1,000 1,252E-03 0,01358939 ! positive regulation of cell development GO:0010720 85 36 2,000 1,309E-03 0,01415403 ! embryonic organ development GO:0048568 67 36 2,000 1,309E-03 0,01409168 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 3,000 1,326E-03 0,01420527 ! cell junction organization GO:0034330 96 37 2,000 1,419E-03 0,01513439 ! meiosis GO:0007126 143 81 3,000 1,454E-03 0,01544855 GO:0051327|M phase of meiotic cell cycle, ! cell-substrate adhesion GO:0031589 189 82 3,000 1,522E-03 0,01609547 ! meiotic cell cycle GO:0051321 144 82 3,000 1,522E-03 0,01602609 ! meiosis I GO:0007127 74 38 2,000 1,533E-03 0,01607865 ! regulation of developmental growth GO:0048638 16 10 1,000 1,558E-03 0,01626898 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 1,558E-03 0,01619975 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,558E-03 0,01613111 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 1,558E-03 0,01606304 ! B cell proliferation GO:0042100 19 10 1,000 1,558E-03 0,01599555 ! neurotransmitter biosynthetic process GO:0042136 18 10 1,000 1,558E-03 0,01592862 ! motor axon guidance GO:0008045 22 10 1,000 1,558E-03 0,01586225 ! protein heterooligomerization GO:0051291 17 10 1,000 1,558E-03 0,01579644 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 1,558E-03 0,01573116 ! induction of an organ GO:0001759 17 10 1,000 1,558E-03 0,01566642 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 1,558E-03 0,01560222 GO:0043470|regulation of carbohydrate catabolic process, ! blastocyst formation GO:0001825 18 10 1,000 1,558E-03 0,01553853 ! response to nicotine GO:0035094 20 10 1,000 1,558E-03 0,01547537 ! response to nutrient GO:0007584 135 84 3,000 1,663E-03 0,01645211 ! regulation of ligase activity GO:0051340 147 84 3,000 1,663E-03 0,01638577 ! negative regulation of transport GO:0051051 164 85 3,000 1,737E-03 0,0170465 ! negative regulation of growth GO:0045926 168 85 3,000 1,737E-03 0,01697831 ! cellular response to hormone stimulus GO:0032870 182 85 3,000 1,737E-03 0,01691067 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,897E-03 0,0183912 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,897E-03 0,01831851 ! telomere maintenance via telomerase GO:0007004 24 11 1,000 1,897E-03 0,01824639 GO:0010833|telomere maintenance via telomere lengthening, ! behavioral fear response GO:0001662 27 11 1,000 1,897E-03 0,01817484 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 1,897E-03 0,01810384 ! regulation of smoothened signaling pathway GO:0008589 27 11 1,000 1,897E-03 0,0180334 ! alpha-beta T cell activation GO:0046631 26 11 1,000 1,897E-03 0,0179635 ! neuroblast proliferation GO:0007405 25 11 1,000 1,897E-03 0,01789414 ! apical protein localization GO:0045176 18 11 1,000 1,897E-03 0,01782532 ! oocyte development GO:0048599 20 11 1,000 1,897E-03 0,01775702 ! cardiac cell differentiation GO:0035051 36 11 1,000 1,897E-03 0,01768925 ! sequestering of metal ion GO:0051238 15 11 1,000 1,897E-03 0,01762199 ! mesenchymal cell development GO:0014031 94 41 2,000 1,912E-03 0,01769677 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! T cell differentiation GO:0030217 93 42 2,000 2,05E-03 0,0189029 ! tube morphogenesis GO:0035239 194 89 3,000 2,057E-03 0,01888795 ! development of primary male sexual characteristics GO:0046546 80 43 2,000 2,195E-03 0,02008001 ! neuron migration GO:0001764 85 43 2,000 2,195E-03 0,02000508 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 2,268E-03 0,02059325 ! virus-host interaction GO:0019048 30 12 1,000 2,268E-03 0,02051697 ! regulation of B cell proliferation GO:0030888 22 12 1,000 2,268E-03 0,02044127 ! hippocampus development GO:0021766 29 12 1,000 2,268E-03 0,02036611 ! tyrosine metabolic process GO:0006570 19 12 1,000 2,268E-03 0,02029151 ! mitotic spindle organization GO:0007052 23 12 1,000 2,268E-03 0,02021746 ! cranial nerve development GO:0021545 23 12 1,000 2,268E-03 0,02014394 ! autonomic nervous system development GO:0048483 24 12 1,000 2,268E-03 0,02007095 ! oocyte differentiation GO:0009994 21 12 1,000 2,268E-03 0,01999849 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 2,268E-03 0,01992656 GO:0042130|negative regulation of T cell proliferation, ! developmental induction GO:0031128 22 12 1,000 2,268E-03 0,01985514 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 1,000 2,268E-03 0,01978423 ! localization within membrane GO:0051668 26 12 1,000 2,268E-03 0,01971382 ! regulation of cell adhesion GO:0030155 241 92 3,000 2,321E-03 0,02010675 ! response to reactive oxygen species GO:0000302 75 44 2,000 2,345E-03 0,02024186 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 2,345E-03 0,02017058 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 2,000 2,345E-03 0,02009981 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 2,414E-03 0,02062068 ! regulation of membrane potential GO:0042391 179 94 3,000 2,51E-03 0,02136279 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 2,664E-03 0,02259874 ! leukocyte migration GO:0050900 75 46 2,000 2,664E-03 0,02252055 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,669E-03 0,02248618 ! asymmetric protein localization GO:0008105 24 13 1,000 2,669E-03 0,02240891 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 2,669E-03 0,02233217 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 2,669E-03 0,02225595 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,669E-03 0,02218025 ! gland morphogenesis GO:0022612 31 13 1,000 2,669E-03 0,02210506 ! aromatic amino acid family catabolic process GO:0009074 20 13 1,000 2,669E-03 0,02203038 ! spleen development GO:0048536 24 13 1,000 2,669E-03 0,02195621 ! digestive tract morphogenesis GO:0048546 31 13 1,000 2,669E-03 0,02188253 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 1,000 2,669E-03 0,02180934 ! sex differentiation GO:0007548 171 96 3,000 2,709E-03 0,02205751 ! regulation of T cell activation GO:0050863 175 96 3,000 2,709E-03 0,02198423 ! regulation of DNA metabolic process GO:0051052 188 97 3,000 2,812E-03 0,02274817 ! leukocyte differentiation GO:0002521 232 98 3,000 2,918E-03 0,0235286 ! positive regulation of cell cycle GO:0045787 96 48 2,000 3,009E-03 0,02418058 ! positive regulation of defense response GO:0031349 88 48 2,000 3,009E-03 0,0241013 ! endosome transport GO:0016197 127 48 2,000 3,009E-03 0,02402253 ! male sex differentiation GO:0046661 93 48 2,000 3,009E-03 0,02394428 ! regulation of inflammatory response GO:0050727 84 48 2,000 3,009E-03 0,02386654 ! JAK-STAT cascade GO:0007259 82 48 2,000 3,009E-03 0,02378931 ! hair follicle morphogenesis GO:0031069 27 14 1,000 3,102E-03 0,02444475 ! palate development GO:0060021 32 14 1,000 3,102E-03 0,02436615 ! fear response GO:0042596 34 14 1,000 3,102E-03 0,02428806 ! bone mineralization GO:0030282 18 14 1,000 3,102E-03 0,02421046 ! RNA-dependent DNA replication GO:0006278 28 14 1,000 3,102E-03 0,02413336 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 3,102E-03 0,02405674 ! response to gamma radiation GO:0010332 30 14 1,000 3,102E-03 0,02398061 ! positive regulation of bone mineralization GO:0030501 32 14 1,000 3,102E-03 0,02390496 ! detection of stimulus involved in sensory perception GO:0050906 75 49 2,000 3,191E-03 0,02451585 ! JNK cascade GO:0007254 106 49 2,000 3,191E-03 0,024439 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 3,191E-03 0,02436263 ! regulation of action potential GO:0001508 102 50 2,000 3,38E-03 0,02572394 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 3,38E-03 0,02564405 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 3,565E-03 0,02696376 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 3,565E-03 0,02688054 ! regulation of mRNA processing GO:0050684 26 15 1,000 3,565E-03 0,02679783 ! G1/S transition checkpoint GO:0031575 37 15 1,000 3,565E-03 0,02671562 ! positive regulation of biomineral formation GO:0070169 33 15 1,000 3,565E-03 0,02663392 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 3,565E-03 0,02655272 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 3,565E-03 0,02647202 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 2,000 3,576E-03 0,02647002 ! response to temperature stimulus GO:0009266 84 51 2,000 3,576E-03 0,02639005 ! detection of abiotic stimulus GO:0009582 80 51 2,000 3,576E-03 0,02631056 ! histone modification GO:0016570 104 52 2,000 3,778E-03 0,02771587 ! positive regulation of growth GO:0045927 96 53 2,000 3,987E-03 0,02916285 ! inner ear development GO:0048839 89 53 2,000 3,987E-03 0,0290758 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 2,000 3,987E-03 0,02898926 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 3,987E-03 0,02890324 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! synapse organization GO:0050808 102 53 2,000 3,987E-03 0,02881773 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 4,058E-03 0,02924581 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 4,058E-03 0,02915979 ! heterophilic cell adhesion GO:0007157 43 16 1,000 4,058E-03 0,02907428 ! glutamate metabolic process GO:0006536 25 16 1,000 4,058E-03 0,02898927 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 4,058E-03 0,02890475 ! biomineral formation GO:0031214 22 16 1,000 4,058E-03 0,02882073 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 4,058E-03 0,02873719 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! covalent chromatin modification GO:0016569 115 54 2,000 4,203E-03 0,02967716 ! epithelial tube morphogenesis GO:0060562 114 54 2,000 4,203E-03 0,02959164 ! metencephalon development GO:0022037 32 17 1,000 4,581E-03 0,03216111 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 4,581E-03 0,03206896 ! signal complex assembly GO:0007172 47 17 1,000 4,581E-03 0,03197734 ! regulation of muscle cell differentiation GO:0051147 36 17 1,000 4,581E-03 0,03188623 ! activation of MAPKK activity GO:0000186 43 17 1,000 4,581E-03 0,03179565 ! regulation of survival gene product expression GO:0045884 38 17 1,000 4,581E-03 0,03170557 ! regulation of striated muscle contraction GO:0006942 23 17 1,000 4,581E-03 0,03161601 ! regulation of protein binding GO:0043393 33 17 1,000 4,581E-03 0,03152695 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 4,581E-03 0,03143839 ! heart morphogenesis GO:0003007 105 57 2,000 4,894E-03 0,0334874 ! limbic system development GO:0021761 40 18 1,000 5,134E-03 0,03503241 ! patterning of blood vessels GO:0001569 43 18 1,000 5,134E-03 0,03493482 ! regulation of viral genome replication GO:0045069 30 18 1,000 5,134E-03 0,03483778 ! epidermis morphogenesis GO:0048730 43 18 1,000 5,134E-03 0,03474128 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 1,000 5,134E-03 0,03464531 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 5,134E-03 0,03454987 ! nerve development GO:0021675 34 18 1,000 5,134E-03 0,03445495 ! defense response to virus GO:0051607 43 18 1,000 5,134E-03 0,03436055 ! neuromuscular junction development GO:0007528 43 19 1,000 5,715E-03 0,03814763 ! embryonic organ morphogenesis GO:0048562 34 19 1,000 5,715E-03 0,03804369 ! camera-type eye development GO:0043010 126 61 2,000 5,915E-03 0,0392659 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 5,915E-03 0,03915949 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 6,325E-03 0,04176344 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 6,325E-03 0,04165087 GO:0010675|regulation of cellular carbohydrate metabolic process, ! actin filament bundle formation GO:0051017 47 20 1,000 6,325E-03 0,0415389 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 6,325E-03 0,04142754 ! aromatic compound catabolic process GO:0019439 31 20 1,000 6,325E-03 0,04131677 ! negative regulation of T cell activation GO:0050868 41 20 1,000 6,325E-03 0,04120659 ! regulation of mitosis GO:0007088 112 63 2,000 6,47E-03 0,04203499 GO:0051783|regulation of nuclear division, ! lipid phosphorylation GO:0046834 43 21 1,000 6,964E-03 0,04512477 ! ovarian follicle development GO:0001541 39 21 1,000 6,964E-03 0,04500539 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 6,964E-03 0,04488664 ! neurotransmitter metabolic process GO:0042133 39 21 1,000 6,964E-03 0,04476852 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 6,964E-03 0,04465101 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 6,964E-03 0,04453413 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 6,964E-03 0,04441785 ! multicellular organism reproduction GO:0032504 123 65 2,000 7,054E-03 0,04487951 GO:0048609|reproductive process in a multicellular organism, ! gonad development GO:0008406 115 66 2,000 7,358E-03 0,04669035 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 7,63E-03 0,04828977 ! apoptotic nuclear changes GO:0030262 34 22 1,000 7,63E-03 0,04816499 ! cell aging GO:0007569 48 22 1,000 7,63E-03 0,04804086 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 7,63E-03 0,04791736 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 7,63E-03 0,04779449 ! renal system process GO:0003014 42 22 1,000 7,63E-03 0,04767226 ! G1 phase GO:0051318 44 22 1,000 7,63E-03 0,04755064 ! positive regulation of B cell activation GO:0050871 42 22 1,000 7,63E-03 0,04742965 ! response to cytokine stimulus GO:0034097 69 22 1,000 7,63E-03 0,04730927 ! gut development GO:0048565 44 22 1,000 7,63E-03 0,0471895 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 7,63E-03 0,04707033 ! myeloid cell differentiation GO:0030099 126 67 2,000 7,669E-03 0,04719522 ! detection of external stimulus GO:0009581 102 68 2,000 7,989E-03 0,04903513 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 2,000 7,989E-03 0,04891224 ! lung development GO:0030324 165 69 2,000 8,315E-03 0,05078582 ! cellular amino acid catabolic process GO:0009063 120 69 2,000 8,315E-03 0,05065917 ! positive regulation of DNA replication GO:0045740 44 23 1,000 8,324E-03 0,05058471 ! gluconeogenesis GO:0006094 38 23 1,000 8,324E-03 0,05045919 ! regeneration GO:0031099 42 23 1,000 8,324E-03 0,05033429 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 8,324E-03 0,05021001 GO:0010810|regulation of cell-substrate adhesion, ! response to ethanol GO:0045471 47 23 1,000 8,324E-03 0,05008634 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 8,324E-03 0,04996328 ! regulation of bone mineralization GO:0030500 54 23 1,000 8,324E-03 0,04984082 ! acetyl-CoA catabolic process GO:0046356 37 23 1,000 8,324E-03 0,04971896 GO:0006099|tricarboxylic acid cycle, ! germ cell development GO:0007281 133 70 2,000 8,65E-03 0,05154059 ! cell cycle checkpoint GO:0000075 145 71 2,000 8,992E-03 0,05345015 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 9,045E-03 0,05363297 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 9,045E-03 0,05350311 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 9,045E-03 0,05337387 ! regulation of viral reproduction GO:0050792 41 24 1,000 9,045E-03 0,05324526 ! pallium development GO:0021543 56 24 1,000 9,045E-03 0,05311727 ! oogenesis GO:0048477 44 24 1,000 9,045E-03 0,05298989 ! aromatic amino acid family metabolic process GO:0009072 37 24 1,000 9,045E-03 0,05286312 ! glutamine family amino acid catabolic process GO:0009065 45 24 1,000 9,045E-03 0,05273695 ! respiratory tube development GO:0030323 171 72 2,000 9,342E-03 0,05434173 ! actin filament organization GO:0007015 167 72 2,000 9,342E-03 0,05421265 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 9,793E-03 0,05669239 ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 9,793E-03 0,05655836 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 9,793E-03 0,05642497 ! phototransduction GO:0007602 37 25 1,000 9,793E-03 0,05629221 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 9,793E-03 0,05616007 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 9,793E-03 0,05602854 ! interaction with host GO:0051701 66 25 1,000 9,793E-03 0,05589764 ! lymphocyte proliferation GO:0046651 55 25 1,000 9,793E-03 0,05576734 ! regulation of biomineral formation GO:0070167 56 25 1,000 9,793E-03 0,05563765 ! protein tetramerization GO:0051262 57 25 1,000 9,793E-03 0,05550856 ! respiratory system development GO:0060541 175 74 2,000 0,01006645 0,05692672 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,01044036 0,05890487 ! eye development GO:0001654 155 75 2,000 0,01044036 0,05876914 ! myelination GO:0042552 50 26 1,000 0,01056751 0,05934811 ! molting cycle process GO:0022404 52 26 1,000 0,01056751 0,05921199 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,01056751 0,05907649 ! osteoblast differentiation GO:0001649 63 26 1,000 0,01056751 0,05894161 ! coenzyme catabolic process GO:0009109 42 26 1,000 0,01056751 0,05880735 ! negative regulation of cell development GO:0010721 83 26 1,000 0,01056751 0,0586737 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 0,01056751 0,05854065 GO:0045840|positive regulation of mitosis, ! blastocyst development GO:0001824 50 26 1,000 0,01056751 0,05840821 ! telomere organization GO:0032200 46 26 1,000 0,01056751 0,05827636 GO:0000723|telomere maintenance, ! learning or memory GO:0007611 161 76 2,000 0,01082224 0,05954671 ! lymphocyte differentiation GO:0030098 193 76 2,000 0,01082224 0,0594129 ! amine catabolic process GO:0009310 136 77 2,000 0,01121212 0,06141527 ! regulation of catabolic process GO:0009894 173 77 2,000 0,01121212 0,06127788 ! response to toxin GO:0009636 49 27 1,000 0,01136826 0,06199256 ! cellular response to nutrient levels GO:0031669 45 27 1,000 0,01136826 0,06185449 ! leukocyte proliferation GO:0070661 59 27 1,000 0,01136826 0,06171703 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 0,01136826 0,06158019 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 0,01136826 0,06144395 ! mitochondrial membrane organization GO:0007006 60 27 1,000 0,01136826 0,06130831 ! cellular response to oxidative stress GO:0034599 43 27 1,000 0,01136826 0,06117327 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 0,01161003 0,06233691 ! response to steroid hormone stimulus GO:0048545 147 79 2,000 0,01201598 0,06437511 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 0,01219487 0,06519053 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 0,01219487 0,0650482 ! glutathione metabolic process GO:0006749 42 28 1,000 0,01219487 0,06490648 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 0,01219487 0,06476538 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 2,000 0,01243002 0,06587102 ! activation of protein kinase activity GO:0032147 170 80 2,000 0,01243002 0,06572845 ! development of primary sexual characteristics GO:0045137 143 80 2,000 0,01243002 0,06558648 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01243002 0,06544513 ! response to hypoxia GO:0001666 178 81 2,000 0,01285216 0,06752221 ! somitogenesis GO:0001756 52 29 1,000 0,01304701 0,06839879 ! synaptogenesis GO:0007416 46 29 1,000 0,01304701 0,06825232 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 0,01304701 0,06810648 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01304701 0,06796127 ! exocytosis GO:0006887 153 83 2,000 0,01372083 0,07131912 ! response to oxygen levels GO:0070482 183 83 2,000 0,01372083 0,0711677 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 1,000 0,01392433 0,0720702 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01392433 0,07191783 ! regulation of B cell activation GO:0050864 55 30 1,000 0,01392433 0,07176611 ! response to metal ion GO:0010038 158 84 2,000 0,0141674 0,07286518 ! T cell activation GO:0042110 189 84 2,000 0,0141674 0,0727121 ! regulation of neuron differentiation GO:0045664 187 85 2,000 0,01462215 0,07488873 ! ovulation cycle process GO:0022602 55 31 1,000 0,01482651 0,0757765 ! erythrocyte differentiation GO:0030218 62 31 1,000 0,01482651 0,0756183 ! detection of light stimulus GO:0009583 44 31 1,000 0,01482651 0,07546076 ! ensheathment of neurons GO:0007272 64 31 1,000 0,01482651 0,07530388 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 1,000 0,01482651 0,07514765 ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 0,01482651 0,07499206 ! eye morphogenesis GO:0048592 65 31 1,000 0,01482651 0,07483712 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,01508511 0,07598541 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 2,000 0,01555628 0,07819751 ! response to mechanical stimulus GO:0009612 60 32 1,000 0,01575323 0,07902492 ! hexose biosynthetic process GO:0019319 53 32 1,000 0,01575323 0,07886298 ! ovulation cycle GO:0042698 57 32 1,000 0,01575323 0,07870171 ! peripheral nervous system development GO:0007422 68 32 1,000 0,01575323 0,07854109 ! BMP signaling pathway GO:0030509 71 32 1,000 0,01575323 0,07838113 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,01575323 0,07822182 ! myeloid leukocyte activation GO:0002274 53 32 1,000 0,01575323 0,07806316 ! triglyceride metabolic process GO:0006641 46 33 1,000 0,01670416 0,0826078 ! response to ionizing radiation GO:0010212 74 33 1,000 0,01670416 0,08244091 ! positive regulation of neurogenesis GO:0050769 72 33 1,000 0,01670416 0,0822747 ! negative regulation of protein transport GO:0051224 74 33 1,000 0,01670416 0,08210916 ! response to inorganic substance GO:0010035 173 90 2,000 0,01701922 0,08348988 ! regulation of cell cycle process GO:0010564 161 90 2,000 0,01701922 0,08332256 ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,01767897 0,08637946 ! post-embryonic development GO:0009791 76 34 1,000 0,01767897 0,08620704 ! cell fate specification GO:0001708 56 34 1,000 0,01767897 0,08603532 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01767897 0,08586427 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 2,000 0,01855655 0,08994774 GO:0010498|proteasomal protein catabolic process, ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 0,01867736 0,09035404 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 0,01867736 0,09017548 ! telencephalon development GO:0021537 81 35 1,000 0,01867736 0,08999762 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01867736 0,08982046 ! placenta development GO:0001890 53 35 1,000 0,01867736 0,08964399 ! nitrogen compound catabolic process GO:0044270 167 94 2,000 0,01908557 0,09142363 ! female pregnancy GO:0007565 166 94 2,000 0,01908557 0,09124472 ! regulation of defense response GO:0031347 171 95 2,000 0,01962289 0,09363031 ! regulation of muscle development GO:0048634 82 36 1,000 0,01969901 0,09381028 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01969901 0,09362777 ! aerobic respiration GO:0009060 56 36 1,000 0,01969901 0,09344597 ! monosaccharide biosynthetic process GO:0046364 57 36 1,000 0,01969901 0,09326487 ! response to protein stimulus GO:0051789 158 96 2,000 0,02016851 0,09530303 ! regulation of protein localization GO:0032880 188 97 2,000 0,02072244 0,0977315 ! sister chromatid segregation GO:0000819 65 37 1,000 0,0207436 0,09764279 ! odontogenesis GO:0042476 74 37 1,000 0,0207436 0,09745502 ! female gonad development GO:0008585 71 37 1,000 0,0207436 0,09726797 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 0,0207436 0,09708163 ! negative regulation of cell activation GO:0050866 69 37 1,000 0,0207436 0,096896 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,02181083 0,10168673 ! neutral lipid metabolic process GO:0006638 54 38 1,000 0,02181083 0,10149304 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 77 38 1,000 0,02181083 0,10130009 ! pigment metabolic process GO:0042440 87 38 1,000 0,02181083 0,10110787 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,02243409 0,10380018 GO:0060538|skeletal muscle organ development, ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 0,02290038 0,10575735 ! carbohydrate homeostasis GO:0033500 59 39 1,000 0,02290038 0,10555781 GO:0042593|glucose homeostasis, ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,02290038 0,10535902 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,02290038 0,10516098 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 93 40 1,000 0,02401197 0,11005862 ! learning GO:0007612 82 40 1,000 0,02401197 0,10985252 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,02401197 0,10964718 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 1,000 0,02401197 0,10944262 ! mismatch repair GO:0006298 58 40 1,000 0,02401197 0,10923881 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,02401197 0,10903577 ! glycerol ether metabolic process GO:0006662 57 40 1,000 0,02401197 0,10883348 ! ear morphogenesis GO:0042471 64 42 1,000 0,02630002 0,11898325 ! organic ether metabolic process GO:0018904 59 42 1,000 0,02630002 0,11876332 ! alcohol biosynthetic process GO:0046165 65 42 1,000 0,02630002 0,1185442 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,02630002 0,11832589 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,02630002 0,11810838 ! cytokinesis GO:0000910 84 42 1,000 0,02630002 0,11789167 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,0274759 0,12293703 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,0274759 0,12271229 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 1,000 0,0274759 0,12248836 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 1,000 0,0274759 0,12226525 ! glucose transport GO:0015758 66 43 1,000 0,0274759 0,12204295 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,0274759 0,12182145 ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,0274759 0,12160076 ! segmentation GO:0035282 78 43 1,000 0,0274759 0,12138087 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,0274759 0,12116177 ! hexose transport GO:0008645 68 44 1,000 0,02867262 0,12621117 GO:0015749|monosaccharide transport, ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02960755 0,13009215 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02960755 0,12985859 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02960755 0,12962587 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02960755 0,12939398 ! neuron fate determination GO:0048664 7 5 0,000 0,02960755 0,12916292 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02960755 0,12893268 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02960755 0,12870326 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02960755 0,12847466 ! polyol transport GO:0015791 12 5 0,000 0,02960755 0,12824687 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02960755 0,12801988 ! response to superoxide GO:0000303 10 5 0,000 0,02960755 0,1277937 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02960755 0,12756831 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02960755 0,12734372 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02960755 0,12711992 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02960755 0,1268969 ! female meiosis GO:0007143 10 5 0,000 0,02960755 0,12667466 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02960755 0,1264532 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02960755 0,12623252 ! hypothalamus development GO:0021854 9 5 0,000 0,02960755 0,1260126 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02960755 0,12579345 ! cobalt ion transport GO:0006824 11 5 0,000 0,02960755 0,12557506 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02960755 0,12535742 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02960755 0,12514054 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02960755 0,12492441 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02960755 0,12470902 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02960755 0,12449438 ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02960755 0,12428047 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02960755 0,1240673 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02960755 0,12385485 ! transposition GO:0032196 9 5 0,000 0,02960755 0,12364313 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02960755 0,12343214 ! negative chemotaxis GO:0050919 16 5 0,000 0,02960755 0,12322186 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02960755 0,1230123 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02960755 0,12280345 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02960755 0,12259531 ! behavioral response to pain GO:0048266 10 5 0,000 0,02960755 0,12238787 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02960755 0,12218114 ! Notch receptor processing GO:0007220 11 5 0,000 0,02960755 0,1219751 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02960755 0,12176975 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02960755 0,1215651 ! micturition GO:0060073 9 5 0,000 0,02960755 0,12136113 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02960755 0,12115784 ! copulation GO:0007620 9 5 0,000 0,02960755 0,12095524 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02960755 0,12075331 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02960755 0,12055206 ! bioluminescence GO:0008218 9 5 0,000 0,02960755 0,12035147 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02960755 0,12015155 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02960755 0,11995229 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02960755 0,1197537 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02960755 0,11955576 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02960755 0,11935847 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02960755 0,11916183 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02960755 0,11896584 ! grooming behavior GO:0007625 6 5 0,000 0,02960755 0,1187705 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02960755 0,11857579 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02960755 0,11838172 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02960755 0,11818829 ! response to protozoan GO:0001562 13 5 0,000 0,02960755 0,11799549 ! lymph vessel development GO:0001945 10 5 0,000 0,02960755 0,11780331 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02960755 0,11761176 ! endochondral ossification GO:0001958 17 5 0,000 0,02960755 0,11742083 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02960755 0,11723052 ! single strand break repair GO:0000012 8 5 0,000 0,02960755 0,11704083 ! anagen GO:0042640 7 5 0,000 0,02960755 0,11685175 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02960755 0,11666328 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02960755 0,11647542 ! cytokine secretion GO:0050663 15 5 0,000 0,02960755 0,11628816 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02960755 0,1161015 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02960755 0,11591544 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02960755 0,11572997 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02960755 0,1155451 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02960755 0,11536082 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02960755 0,11517712 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02960755 0,11499401 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02960755 0,11481148 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02960755 0,11462953 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02960755 0,11444815 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02960755 0,11426735 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02960755 0,11408712 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02960755 0,11390745 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02960755 0,11372835 ! microvillus organization GO:0032528 8 5 0,000 0,02960755 0,11354982 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,02960755 0,11337184 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02960755 0,11319442 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02960755 0,11301755 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02960755 0,11284124 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02960755 0,11266547 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02960755 0,11249025 ! polyol catabolic process GO:0046174 9 5 0,000 0,02960755 0,11231558 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02960755 0,11214145 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02960755 0,11196785 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02960755 0,1117948 ! muscle cell migration GO:0014812 8 5 0,000 0,02960755 0,11162227 ! mitochondrial fission GO:0000266 8 5 0,000 0,02960755 0,11145028 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02960755 0,11127882 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02960755 0,11110788 ! mRNA transcription GO:0009299 10 5 0,000 0,02960755 0,11093747 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02960755 0,11076759 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02960755 0,11059822 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02960755 0,11042936 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02960755 0,11026103 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02960755 0,1100932 ! monocyte activation GO:0042117 10 5 0,000 0,02960755 0,10992589 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02960755 0,10975908 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02960755 0,10959278 ! response to food GO:0032094 6 5 0,000 0,02960755 0,10942698 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02960755 0,10926168 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02960755 0,10909688 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02960755 0,10893258 ! forebrain neuron development GO:0021884 13 5 0,000 0,02960755 0,10876877 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02960755 0,10860546 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02960755 0,10844263 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02960755 0,10828029 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02960755 0,10811844 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02960755 0,10795706 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02960755 0,10779617 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02960755 0,10763576 ! lipid glycosylation GO:0030259 7 5 0,000 0,02960755 0,10747583 ! nucleobase transport GO:0015851 6 5 0,000 0,02960755 0,10731637 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02960755 0,10715738 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02960755 0,10699887 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02960755 0,10684082 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02960755 0,10668323 ! basic amino acid transport GO:0015802 12 5 0,000 0,02960755 0,10652612 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02960755 0,10636946 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02960755 0,10621326 ! actin nucleation GO:0045010 11 5 0,000 0,02960755 0,10605753 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02960755 0,10590224 ! depurination GO:0045007 5 5 0,000 0,02960755 0,10574742 ! depyrimidination GO:0045008 10 5 0,000 0,02960755 0,10559304 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02960755 0,10543912 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02960755 0,10528564 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02960755 0,10513261 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02960755 0,10498002 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02960755 0,10482787 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02960755 0,10467617 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02960755 0,1045249 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02960755 0,10437407 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02960755 0,10422368 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02960755 0,10407372 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02960755 0,10392419 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02960755 0,10377508 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02960755 0,10362641 ! response to arsenic GO:0046685 11 5 0,000 0,02960755 0,10347816 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02960755 0,10333033 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02960755 0,10318293 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02960755 0,10303594 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02960755 0,10288938 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02960755 0,10274323 ! response to cadmium ion GO:0046686 7 5 0,000 0,02960755 0,10259749 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02960755 0,10245217 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02960755 0,10230726 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02960755 0,10216276 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02960755 0,10201866 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02960755 0,10187498 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02960755 0,10173169 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02960755 0,10158881 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02960755 0,10144633 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02960755 0,10130425 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02960755 0,10116256 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02960755 0,10102128 ! embryonic cleavage GO:0040016 6 5 0,000 0,02960755 0,10088038 ! peroxisome fission GO:0016559 5 5 0,000 0,02960755 0,10073988 ! histone demethylation GO:0016577 13 5 0,000 0,02960755 0,10059977 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02960755 0,10046005 ! mitotic recombination GO:0006312 9 5 0,000 0,02960755 0,10032071 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02960755 0,10018176 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02960755 0,1000432 ! metaphase plate congression GO:0051310 7 5 0,000 0,02960755 0,09990502 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02960755 0,09976722 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02960755 0,0996298 ! enteric nervous system development GO:0048484 8 5 0,000 0,02960755 0,09949276 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02960755 0,09935609 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02960755 0,0992198 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02960755 0,09908388 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02960755 0,09894834 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02960755 0,09881316 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02960755 0,09867835 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02960755 0,09854391 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02960755 0,09840984 ! metaphase GO:0051323 11 5 0,000 0,02960755 0,09827613 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02960755 0,09814279 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02960755 0,0980098 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02960755 0,09787718 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02960755 0,09774491 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02960755 0,097613 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02960755 0,09748145 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02960755 0,09735025 ! response to redox state GO:0051775 6 5 0,000 0,02960755 0,0972194 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02960755 0,0970889 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02960755 0,09695876 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02960755 0,09682896 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02960755 0,09669951 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02960755 0,0965704 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02960755 0,09644164 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02960755 0,09631323 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02960755 0,09618515 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02960755 0,09605741 ! striatum development GO:0021756 14 5 0,000 0,02960755 0,09593002 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02960755 0,09580296 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02960755 0,09567623 ! glial cell migration GO:0008347 10 5 0,000 0,02960755 0,09554985 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02960755 0,09542379 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02960755 0,09529807 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02960755 0,09517268 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02960755 0,09504761 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02960755 0,09492288 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02960755 0,09479847 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02960755 0,09467439 ! neuroprotection GO:0043526 8 5 0,000 0,02960755 0,09455063 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02960755 0,0944272 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02960755 0,09430408 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02960755 0,09418129 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02960755 0,09405882 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02960755 0,09393667 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02960755 0,09381483 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02960755 0,09369331 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02960755 0,0935721 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02960755 0,09345121 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02960755 0,09333062 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02960755 0,09321035 ! spindle assembly GO:0051225 6 5 0,000 0,02960755 0,09309039 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02960755 0,09297074 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02960755 0,09285139 ! protein palmitoylation GO:0018345 12 5 0,000 0,02960755 0,09273235 ! drug metabolic process GO:0017144 7 5 0,000 0,02960755 0,09261361 ! stem cell division GO:0017145 11 5 0,000 0,02960755 0,09249518 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,02960755 0,09237705 ! organ regeneration GO:0031100 7 5 0,000 0,02960755 0,09225923 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02960755 0,0921417 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02960755 0,09202447 ! B cell differentiation GO:0030183 124 45 1,000 0,02988989 0,09278398 ! female gamete generation GO:0007292 71 45 1,000 0,02988989 0,09266623 ! developmental growth GO:0048589 88 45 1,000 0,02988989 0,09254878 ! maintenance of location in cell GO:0051651 101 45 1,000 0,02988989 0,09243163 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,03112742 0,0961369 ! negative regulation of cell migration GO:0030336 122 46 1,000 0,03112742 0,09601551 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,03238494 0,09976847 ! mitochondrial transport GO:0006839 94 48 1,000 0,03366215 0,10357259 ! cellular component disassembly GO:0022411 89 48 1,000 0,03366215 0,10344231 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,03366215 0,10331236 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,03366215 0,10318273 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03542351 0,10844566 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03542351 0,10830993 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,03542351 0,10817455 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,03542351 0,1080395 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03542351 0,10790478 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,03542351 0,10777041 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,03542351 0,10763636 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03542351 0,10750265 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,03542351 0,10736928 ! response to oxygen radical GO:0000305 11 6 0,000 0,03542351 0,10723623 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,03542351 0,10710351 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,03542351 0,10697112 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,03542351 0,10683906 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,03542351 0,10670732 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03542351 0,10657591 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,03542351 0,10644482 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,03542351 0,10631405 ! forebrain regionalization GO:0021871 9 6 0,000 0,03542351 0,1061836 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03542351 0,10605348 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03542351 0,10592367 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,03542351 0,10579418 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03542351 0,105665 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,03542351 0,10553614 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03542351 0,1054076 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,03542351 0,10527936 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,03542351 0,10515144 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03542351 0,10502383 ! malate metabolic process GO:0006108 13 6 0,000 0,03542351 0,10489653 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,03542351 0,10476954 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,03542351 0,10464285 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,03542351 0,10451647 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,03542351 0,10439039 ! protein refolding GO:0042026 15 6 0,000 0,03542351 0,10426462 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03542351 0,10413915 ! opsonization GO:0008228 8 6 0,000 0,03542351 0,10401399 ! mating behavior GO:0007617 7 6 0,000 0,03542351 0,10388912 ! erythrocyte maturation GO:0043249 8 6 0,000 0,03542351 0,10376455 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,03542351 0,10364028 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,03542351 0,10351631 GO:0046530|photoreceptor cell differentiation, ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03542351 0,10339264 ! response to interferon-gamma GO:0034341 16 6 0,000 0,03542351 0,10326926 ! toxin metabolic process GO:0009404 11 6 0,000 0,03542351 0,10314617 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03542351 0,10302338 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,03542351 0,10290088 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,03542351 0,10277867 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,03542351 0,10265675 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,03542351 0,10253511 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,03542351 0,10241377 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,03542351 0,10229271 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,03542351 0,10217194 ! thymic T cell selection GO:0045061 16 6 0,000 0,03542351 0,10205146 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,03542351 0,10193126 ! protein lipoylation GO:0009249 10 6 0,000 0,03542351 0,10181134 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,03542351 0,1016917 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,03542351 0,10157234 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,03542351 0,10145327 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,03542351 0,10133447 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,03542351 0,10121595 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03542351 0,10109771 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,03542351 0,10097974 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03542351 0,10086205 ! hyperosmotic response GO:0006972 10 6 0,000 0,03542351 0,10074463 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,03542351 0,10062748 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,03542351 0,10051061 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,03542351 0,10039401 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03542351 0,10027768 ! urea metabolic process GO:0019627 7 6 0,000 0,03542351 0,10016162 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03542351 0,10004582 ! neutrophil activation GO:0042119 7 6 0,000 0,03542351 0,0999303 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03542351 0,09981504 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,03542351 0,09970004 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03542351 0,09958531 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,03542351 0,09947085 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,03542351 0,09935664 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03542351 0,0992427 ! neuron apoptosis GO:0051402 15 6 0,000 0,03542351 0,09912902 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,03542351 0,0990156 ! T cell mediated immunity GO:0002456 17 6 0,000 0,03542351 0,09890244 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03542351 0,09878954 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,03542351 0,09867689 ! carnitine transport GO:0015879 10 6 0,000 0,03542351 0,09856451 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03542351 0,09845237 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,03542351 0,0983405 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,03542351 0,09822887 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,03542351 0,0981175 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,03542351 0,09800638 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03542351 0,09789552 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,03542351 0,0977849 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,03542351 0,09767453 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,03542351 0,09756442 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,03542351 0,09745455 ! response to UV-C GO:0010225 14 6 0,000 0,03542351 0,09734492 ! astrocyte development GO:0014002 16 6 0,000 0,03542351 0,09723555 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,03542351 0,09712642 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03542351 0,09701753 ! interaction with symbiont GO:0051702 14 6 0,000 0,03542351 0,09690889 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03542351 0,09680049 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,03542351 0,09669233 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,03542351 0,09658442 ! response to copper ion GO:0046688 10 6 0,000 0,03542351 0,09647674 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,03542351 0,09636931 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03542351 0,09626211 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,03542351 0,09615515 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,03542351 0,09604843 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,03542351 0,09594195 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03542351 0,0958357 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,03542351 0,09572969 ! hair follicle maturation GO:0048820 8 6 0,000 0,03542351 0,09562391 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03542351 0,09551836 ! Schwann cell development GO:0014044 15 6 0,000 0,03542351 0,09541305 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,03542351 0,09530797 ! response to pheromone GO:0019236 6 6 0,000 0,03542351 0,09520312 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,03542351 0,0950985 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,03542351 0,09499411 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,03542351 0,09488995 ! subpallium development GO:0021544 15 6 0,000 0,03542351 0,09478602 ! neural tube patterning GO:0021532 8 6 0,000 0,03542351 0,09468232 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,03542351 0,09457884 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,03542351 0,09447559 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03542351 0,09437256 ! G2 phase GO:0051319 16 6 0,000 0,03542351 0,09426976 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,03542351 0,09416718 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,03542351 0,09406482 ! oxygen homeostasis GO:0032364 10 6 0,000 0,03542351 0,09396269 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03542351 0,09386078 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,03542351 0,09375909 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03542351 0,09365762 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,03542351 0,09355636 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03542351 0,09345533 ! receptor internalization GO:0031623 11 6 0,000 0,03542351 0,09335452 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,03542351 0,09325392 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,03542351 0,09315354 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,03542351 0,09305337 ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,03542351 0,09295342 ! protein deubiquitination GO:0016579 16 6 0,000 0,03542351 0,09285369 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,03542351 0,09275417 ! protein destabilization GO:0031648 9 6 0,000 0,03542351 0,09265486 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,03542351 0,09255576 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03542351 0,09245688 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,03542351 0,0923582 ! regulation of viral transcription GO:0046782 11 6 0,000 0,03542351 0,09225974 ! progesterone metabolic process GO:0042448 12 6 0,000 0,03542351 0,09216149 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,03542351 0,09206344 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,03542351 0,09196561 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,03542351 0,09186798 ! determination of adult lifespan GO:0008340 17 6 0,000 0,03542351 0,09177056 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,03542351 0,09167334 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03542351 0,09157633 ! neural plate development GO:0001840 9 6 0,000 0,03542351 0,09147953 ! catecholamine transport GO:0051937 9 6 0,000 0,03542351 0,09138293 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,03542351 0,09128654 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03542351 0,09119034 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,03542351 0,09109435 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,03542351 0,09099857 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,03542351 0,09090298 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03542351 0,09080759 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,03542351 0,09071241 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,03542351 0,09061742 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,03542351 0,09052263 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,03542351 0,09042804 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,03542351 0,09033365 GO:0055081|anion homeostasis, ! endocrine system development GO:0035270 109 50 1,000 0,03627457 0,09240749 ! activation of caspase activity GO:0006919 95 50 1,000 0,03627457 0,09231123 ! peptide metabolic process GO:0006518 80 51 1,000 0,03760923 0,09560805 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,03760923 0,09550867 ! positive regulation of binding GO:0051099 88 52 1,000 0,03896248 0,09884251 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,03896248 0,09873998 ! chromatin remodeling GO:0006338 122 53 1,000 0,04033406 0,10210997 ! vesicle organization GO:0016050 127 53 1,000 0,04033406 0,10200426 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,04033406 0,10189878 ! tRNA transcription GO:0009304 17 7 0,000 0,04120478 0,10399099 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04120478 0,10388367 GO:0045346|regulation of MHC class II biosynthetic process, ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04120478 0,10377658 ! regulation of helicase activity GO:0051095 16 7 0,000 0,04120478 0,1036697 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,04120478 0,10356305 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04120478 0,10345661 ! sleep GO:0030431 16 7 0,000 0,04120478 0,10335039 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04120478 0,10324439 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04120478 0,10313861 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04120478 0,10303304 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04120478 0,10292769 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04120478 0,10282255 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04120478 0,10271763 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04120478 0,10261293 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04120478 0,10250843 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04120478 0,10240415 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04120478 0,10230008 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04120478 0,10219622 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04120478 0,10209258 ! glycolipid transport GO:0046836 11 7 0,000 0,04120478 0,10198914 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04120478 0,10188591 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04120478 0,10178289 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04120478 0,10168008 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04120478 0,10157748 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04120478 0,10147508 ! mRNA stabilization GO:0048255 18 7 0,000 0,04120478 0,10137289 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,04120478 0,10127091 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04120478 0,10116913 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04120478 0,10106755 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,04120478 0,10096618 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04120478 0,10086501 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04120478 0,10076404 ! lipoprotein transport GO:0042953 14 7 0,000 0,04120478 0,10066328 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04120478 0,10056272 ! rhythmic behavior GO:0007622 17 7 0,000 0,04120478 0,10046236 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04120478 0,10036219 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04120478 0,10026223 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04120478 0,10016247 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04120478 0,1000629 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04120478 0,09996354 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04120478 0,09986437 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04120478 0,09976539 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04120478 0,09966661 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04120478 0,09956803 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,04120478 0,09946964 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,04120478 0,09937145 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04120478 0,09927345 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04120478 0,09917565 ! spinal cord patterning GO:0021511 14 7 0,000 0,04120478 0,09907803 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04120478 0,09898061 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04120478 0,09888338 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04120478 0,09878634 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04120478 0,09868949 ! adrenal gland development GO:0030325 17 7 0,000 0,04120478 0,09859283 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04120478 0,09849636 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04120478 0,09840008 ! ovulation GO:0030728 10 7 0,000 0,04120478 0,09830398 ! adenohypophysis development GO:0021984 11 7 0,000 0,04120478 0,09820808 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04120478 0,09811236 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04120478 0,09801683 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! microtubule nucleation GO:0007020 21 7 0,000 0,04120478 0,09792148 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04120478 0,09782632 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04120478 0,09773134 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04120478 0,09763655 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04120478 0,09754194 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04120478 0,09744751 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04120478 0,09735327 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04120478 0,09725921 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04120478 0,09716533 ! galactose metabolic process GO:0006012 13 7 0,000 0,04120478 0,09707163 ! vesicle fusion GO:0006906 20 7 0,000 0,04120478 0,09697811 ! response to dietary excess GO:0002021 8 7 0,000 0,04120478 0,09688477 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04120478 0,09679162 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04120478 0,09669864 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,04120478 0,09660584 ! nucleoside transport GO:0015858 11 7 0,000 0,04120478 0,09651321 ! nucleoside salvage GO:0043174 11 7 0,000 0,04120478 0,09642077 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04120478 0,0963285 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04120478 0,09623641 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04120478 0,09614449 ! parturition GO:0007567 16 7 0,000 0,04120478 0,09605275 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,04120478 0,09596118 ! rRNA modification GO:0000154 14 7 0,000 0,04120478 0,09586979 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04120478 0,09577857 ! spindle checkpoint GO:0031577 16 7 0,000 0,04120478 0,09568753 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,04120478 0,09559666 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04120478 0,09550596 ! monocyte differentiation GO:0030224 16 7 0,000 0,04120478 0,09541543 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04120478 0,09532508 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04120478 0,09523489 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,04120478 0,09514488 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04120478 0,09505503 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,04120478 0,09496536 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04120478 0,09487585 ! fibrinolysis GO:0042730 11 7 0,000 0,04120478 0,09478652 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04120478 0,09469735 ! eating behavior GO:0042755 8 7 0,000 0,04120478 0,09460835 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04120478 0,09451951 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04120478 0,09443084 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04120478 0,09434234 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04120478 0,09425401 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,04120478 0,09416584 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04120478 0,09407783 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04120478 0,09398999 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04120478 0,09390231 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04120478 0,0938148 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04120478 0,09372745 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04120478 0,09364026 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,04120478 0,09355323 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04120478 0,09346637 ! histone ubiquitination GO:0016574 9 7 0,000 0,04120478 0,09337967 ! regulation of meiosis GO:0040020 12 7 0,000 0,04120478 0,09329312 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04120478 0,09320674 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,04120478 0,09312052 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04120478 0,09303446 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04120478 0,09294855 ! transcription termination GO:0006353 14 7 0,000 0,04120478 0,0928628 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04120478 0,09277722 ! anaphase GO:0051322 18 7 0,000 0,04120478 0,09269179 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04120478 0,09260651 ! axonal fasciculation GO:0007413 19 7 0,000 0,04120478 0,0925214 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04120478 0,09243644 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04120478 0,09235163 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04120478 0,09226698 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04120478 0,09218249 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04120478 0,09209815 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04120478 0,09201397 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04120478 0,09192994 ! antibiotic transport GO:0042891 9 7 0,000 0,04120478 0,09184606 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04120478 0,09176233 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04120478 0,09167876 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04120478 0,09159534 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04120478 0,09151207 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04120478 0,09142896 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04120478 0,09134599 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04120478 0,09126317 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04120478 0,09118051 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04120478 0,09109799 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04120478 0,09101562 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,04120478 0,09093341 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04120478 0,09085134 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04120478 0,09076941 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04120478 0,09068764 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04120478 0,09060601 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04120478 0,09052453 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04120478 0,0904432 ! muscle adaptation GO:0043500 13 7 0,000 0,04120478 0,09036201 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04120478 0,09028097 ! retina homeostasis GO:0001895 12 7 0,000 0,04120478 0,09020007 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04120478 0,09011932 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04120478 0,09003871 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04120478 0,08995825 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04120478 0,08987793 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,04172371 0,09092867 ! regulation of translational initiation GO:0006446 87 54 1,000 0,04172371 0,09084762 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,04172371 0,09076673 GO:0010863|positive regulation of phospholipase C activity, ! glutamine family amino acid metabolic process GO:0009064 85 54 1,000 0,04172371 0,09068597 ! regulation of cell shape GO:0008360 142 54 1,000 0,04172371 0,09060536 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,04313117 0,09357854 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,04313117 0,09349551 ! cell maturation GO:0048469 107 55 1,000 0,04313117 0,09341263 ! negative regulation of cell motion GO:0051271 142 55 1,000 0,04313117 0,09332989 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,04455616 0,09632805 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,04455616 0,09624288 ! regulation of DNA replication GO:0006275 105 56 1,000 0,04455616 0,09615786 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,04599844 0,09918286 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,04599844 0,0990954 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,04599844 0,09900809 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,04599844 0,09892093 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,04695156 0,10088185 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,04695156 0,10079321 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,04695156 0,10070471 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,04695156 0,10061638 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,04695156 0,10052819 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04695156 0,10044016 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04695156 0,10035229 ! male meiosis GO:0007140 9 8 0,000 0,04695156 0,10026457 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,04695156 0,100177 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,04695156 0,10008959 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,04695156 0,10000233 ! meiotic prophase I GO:0007128 14 8 0,000 0,04695156 0,09991522 ! response to zinc ion GO:0010043 12 8 0,000 0,04695156 0,09982826 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04695156 0,09974145 ! oligopeptide transport GO:0006857 16 8 0,000 0,04695156 0,09965479 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,04695156 0,09956829 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,04695156 0,09948193 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,04695156 0,09939573 ! signal peptide processing GO:0006465 12 8 0,000 0,04695156 0,09930967 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,04695156 0,09922376 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,04695156 0,099138 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04695156 0,09905239 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,04695156 0,09896693 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,04695156 0,09888161 ! estrogen metabolic process GO:0008210 17 8 0,000 0,04695156 0,09879644 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,04695156 0,09871142 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04695156 0,09862654 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,04695156 0,09854181 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04695156 0,09845723 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04695156 0,09837279 ! reflex GO:0060004 17 8 0,000 0,04695156 0,09828849 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04695156 0,09820434 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,04695156 0,09812033 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04695156 0,09803647 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04695156 0,09795275 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,04695156 0,09786917 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,04695156 0,09778574 ! astrocyte differentiation GO:0048708 19 8 0,000 0,04695156 0,09770244 ! histidine catabolic process GO:0006548 10 8 0,000 0,04695156 0,09761929 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04695156 0,09753628 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,04695156 0,09745341 ! ER overload response GO:0006983 13 8 0,000 0,04695156 0,09737069 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,04695156 0,0972881 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,04695156 0,09720565 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,04695156 0,09712334 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04695156 0,09704117 ! macrophage activation GO:0042116 13 8 0,000 0,04695156 0,09695914 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04695156 0,09687725 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,04695156 0,0967955 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,04695156 0,09671389 ! purine salvage GO:0043101 12 8 0,000 0,04695156 0,09663241 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,04695156 0,09655107 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04695156 0,09646986 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,04695156 0,0963888 ! osteoblast development GO:0002076 17 8 0,000 0,04695156 0,09630787 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,04695156 0,09622707 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,04695156 0,09614641 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,04695156 0,09606589 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,04695156 0,0959855 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04695156 0,09590524 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,04695156 0,09582512 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04695156 0,09574513 ! intermediate filament organization GO:0045109 12 8 0,000 0,04695156 0,09566528 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,04695156 0,09558556 ! cellular extravasation GO:0045123 13 8 0,000 0,04695156 0,09550597 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,04695156 0,09542651 ! response to antibiotic GO:0046677 11 8 0,000 0,04695156 0,09534719 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,04695156 0,095268 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,04695156 0,09518894 ! DNA topological change GO:0006265 12 8 0,000 0,04695156 0,09511001 ! response to tropane GO:0014073 15 8 0,000 0,04695156 0,09503121 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,04695156 0,09495254 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,04695156 0,094874 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04695156 0,09479559 ! mast cell activation GO:0045576 14 8 0,000 0,04695156 0,09471731 ! multicellular organismal aging GO:0010259 20 8 0,000 0,04695156 0,09463917 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,04695156 0,09456114 ! gas homeostasis GO:0033483 14 8 0,000 0,04695156 0,09448325 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,04695156 0,09440549 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,04695156 0,09432785 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04695156 0,09425034 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04695156 0,09417296 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,04695156 0,09409571 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04695156 0,09401858 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,04695156 0,09394158 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,04695156 0,0938647 ! intracellular lipid transport GO:0032365 16 8 0,000 0,04695156 0,09378795 ! response to tumor cell GO:0002347 16 8 0,000 0,04695156 0,09371133 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04695156 0,09363483 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,04695156 0,09355846 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,04695156 0,09348221 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04695156 0,09340608 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,04695156 0,09333008 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,04695156 0,0932542 ! hormone catabolic process GO:0042447 17 8 0,000 0,04695156 0,09317845 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,04695156 0,09310281 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,04695156 0,09302731 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,04695156 0,09295192 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,04695156 0,09287665 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04695156 0,09280151 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,04695156 0,09272649 ! adult feeding behavior GO:0008343 10 8 0,000 0,04695156 0,09265159 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,04695156 0,09257681 ! ATP catabolic process GO:0006200 11 8 0,000 0,04695156 0,09250215 ! blastocyst growth GO:0001832 19 8 0,000 0,04695156 0,09242761 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04695156 0,09235319 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,04695156 0,0922789 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04695156 0,09220472 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,04695156 0,09213066 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,04695156 0,09205672 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,04695156 0,09198289 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,04695156 0,09190919 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,04695156 0,0918356 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,04695156 0,09176213 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04695156 0,09168878 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,04695156 0,09161555 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,04695156 0,09154243 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04695156 0,09146943 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,04695156 0,09139655 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,04695156 0,09132378 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04695156 0,09125113 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,04695156 0,09117859 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,04695156 0,09110617 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,04695156 0,09103386 ! aging GO:0007568 112 58 1,000 0,04745774 0,09194231 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,04745774 0,09186946 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,04745774 0,09179672 ! maintenance of location GO:0051235 124 58 1,000 0,04745774 0,09172409 ! establishment of organelle localization GO:0051656 122 59 1,000 0,04893381 0,09450222 ! regulation of neurotransmitter levels GO:0001505 113 60 1,000 0,05042641 0,09730783 ! lipid modification GO:0030258 112 60 1,000 0,05042641 0,09723103 ! DNA catabolic process GO:0006308 94 60 1,000 0,05042641 0,09715435 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,05266406 0,10138558 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05266406 0,10130575 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,05266406 0,10122604 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,05266406 0,10114646 ! reproductive behavior GO:0019098 22 9 0,000 0,05266406 0,10106701 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05266406 0,10098768 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,05266406 0,10090847 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,05266406 0,10082939 ! UTP metabolic process GO:0046051 10 9 0,000 0,05266406 0,10075043 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,05266406 0,1006716 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,05266406 0,10059288 ! artery development GO:0060840 25 9 0,000 0,05266406 0,1005143 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,05266406 0,10043583 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,05266406 0,10035749 ! equilibrioception GO:0050957 20 9 0,000 0,05266406 0,10027927 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,05266406 0,10020117 ! chemosensory behavior GO:0007635 21 9 0,000 0,05266406 0,10012319 ! microtubule bundle formation GO:0001578 22 9 0,000 0,05266406 0,10004533 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,05266406 0,0999676 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05266406 0,09988998 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,05266406 0,09981249 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,05266406 0,09973512 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,05266406 0,09965786 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,05266406 0,09958073 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05266406 0,09950371 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05266406 0,09942682 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,05266406 0,09935004 ! protein targeting to ER GO:0045047 25 9 0,000 0,05266406 0,09927338 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,05266406 0,09919684 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,05266406 0,09912042 ! glycine catabolic process GO:0006546 15 9 0,000 0,05266406 0,09904411 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,05266406 0,09896792 ! endosome organization GO:0007032 20 9 0,000 0,05266406 0,09889185 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05266406 0,0988159 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,05266406 0,09874006 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05266406 0,09866434 ! mannose metabolic process GO:0006013 13 9 0,000 0,05266406 0,09858874 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,05266406 0,09851325 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,05266406 0,09843787 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,05266406 0,09836261 ! receptor clustering GO:0043113 20 9 0,000 0,05266406 0,09828747 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,05266406 0,09821244 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05266406 0,09813753 ! retinol metabolic process GO:0042572 20 9 0,000 0,05266406 0,09806273 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,05266406 0,09798804 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,05266406 0,09791347 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,05266406 0,09783901 ! macrophage differentiation GO:0030225 15 9 0,000 0,05266406 0,09776467 ! oligodendrocyte development GO:0014003 11 9 0,000 0,05266406 0,09769043 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05266406 0,09761631 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,05266406 0,0975423 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05266406 0,09746841 ! response to amine stimulus GO:0014075 13 9 0,000 0,05266406 0,09739463 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05266406 0,09732095 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,05266406 0,09724739 ! erythrocyte development GO:0048821 17 9 0,000 0,05266406 0,09717394 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05266406 0,0971006 ! renal water homeostasis GO:0003091 15 9 0,000 0,05266406 0,09702738 ! postreplication repair GO:0006301 25 9 0,000 0,05266406 0,09695426 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,05266406 0,09688125 ! icosanoid secretion GO:0032309 15 9 0,000 0,05266406 0,09680835 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05266406 0,09673556 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,05266406 0,09666288 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,05266406 0,09659032 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,05266406 0,09651785 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05266406 0,0964455 ! sterol catabolic process GO:0016127 14 9 0,000 0,05266406 0,09637326 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05266406 0,09630112 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,05266406 0,09622909 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,05266406 0,09615717 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,05266406 0,09608536 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,05266406 0,09601366 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,05266406 0,09594206 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,05266406 0,09587057 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,05266406 0,09579918 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05266406 0,0957279 ! purine base metabolic process GO:0006144 25 9 0,000 0,05266406 0,09565673 ! pigment granule transport GO:0051904 17 9 0,000 0,05266406 0,09558566 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,05266406 0,0955147 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,05266406 0,09544384 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05266406 0,09537309 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,05266406 0,09530244 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,05266406 0,0952319 ! mitochondrion localization GO:0051646 18 9 0,000 0,05266406 0,09516146 ! viral reproductive process GO:0022415 132 62 1,000 0,05346017 0,0965286 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,05346017 0,09645731 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,05812858 0,10480304 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,05834248 0,10511112 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,05834248 0,10503366 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05834248 0,10495631 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,05834248 0,10487908 ! associative learning GO:0008306 21 10 0,000 0,05834248 0,10480197 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05834248 0,10472496 ! phosphate transport GO:0006817 24 10 0,000 0,05834248 0,10464807 ! cell volume homeostasis GO:0006884 17 10 0,000 0,05834248 0,10457129 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,05834248 0,10449463 ! CTP metabolic process GO:0046036 11 10 0,000 0,05834248 0,10441808 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,05834248 0,10434163 ! GTP metabolic process GO:0046039 11 10 0,000 0,05834248 0,10426531 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,05834248 0,10418909 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,05834248 0,10411298 ! social behavior GO:0035176 29 10 0,000 0,05834248 0,10403699 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,05834248 0,1039611 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,05834248 0,10388533 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,05834248 0,10380967 ! androgen metabolic process GO:0008209 17 10 0,000 0,05834248 0,10373411 ! phospholipid efflux GO:0033700 19 10 0,000 0,05834248 0,10365867 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05834248 0,10358334 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,05834248 0,10350811 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,05834248 0,103433 ! lung alveolus development GO:0048286 26 10 0,000 0,05834248 0,10335799 ! pathogenesis GO:0009405 17 10 0,000 0,05834248 0,1032831 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05834248 0,10320831 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,05834248 0,10313363 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,05834248 0,10305906 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,05834248 0,10298459 ! endoderm development GO:0007492 18 10 0,000 0,05834248 0,10291023 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,05834248 0,10283598 ! arginine catabolic process GO:0006527 17 10 0,000 0,05834248 0,10276184 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05834248 0,1026878 ! proline metabolic process GO:0006560 13 10 0,000 0,05834248 0,10261388 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05834248 0,10254005 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,05834248 0,10246634 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,05834248 0,10239272 ! V(D)J recombination GO:0033151 34 10 0,000 0,05834248 0,10231922 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,05834248 0,10224582 ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,05834248 0,10217253 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,05834248 0,10209934 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,05834248 0,10202625 ! multicellular organism growth GO:0035264 19 10 0,000 0,05834248 0,10195327 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,05834248 0,1018804 ! ruffle organization GO:0031529 17 10 0,000 0,05834248 0,10180762 ! epithelial cell development GO:0002064 21 10 0,000 0,05834248 0,10173496 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,05834248 0,10166239 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05834248 0,10158993 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,05834248 0,10151757 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,05834248 0,10144532 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,05834248 0,10137317 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,05834248 0,10130112 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,05834248 0,10122917 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05834248 0,10115733 ! regulation of bone resorption GO:0045124 25 10 0,000 0,05834248 0,10108558 ! brain morphogenesis GO:0048854 23 10 0,000 0,05834248 0,10101394 ! segment specification GO:0007379 15 10 0,000 0,05834248 0,1009424 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,05834248 0,10087096 ! blastoderm segmentation GO:0007350 19 10 0,000 0,05834248 0,10079963 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,05834248 0,10072839 ! response to dsRNA GO:0043331 23 10 0,000 0,05834248 0,10065726 ! DNA ligation GO:0006266 18 10 0,000 0,05834248 0,10058622 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,05834248 0,10051528 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05834248 0,10044445 ! melanosome localization GO:0032400 16 10 0,000 0,05834248 0,10037371 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,05834248 0,10030308 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,05834248 0,10023254 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,05834248 0,1001621 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05834248 0,10009176 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,05834248 0,10002152 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,05834248 0,09995138 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,05834248 0,09988134 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,05834248 0,0998114 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05834248 0,09974155 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05834248 0,0996718 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05834248 0,09960215 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,05834248 0,09953259 ! salivary gland development GO:0007431 28 10 0,000 0,05834248 0,09946314 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,05834248 0,09939377 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,05834248 0,09932451 ! midbrain development GO:0030901 14 10 0,000 0,05834248 0,09925534 ! musculoskeletal movement GO:0050881 16 10 0,000 0,05834248 0,09918627 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,05834248 0,0991173 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,05834248 0,09904842 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,05834248 0,09897963 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,05834248 0,09891095 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,05834248 0,09884235 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05834248 0,09877386 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05834248 0,09870545 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,05834248 0,09863714 ! detection of calcium ion GO:0005513 24 10 0,000 0,05834248 0,09856893 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05834248 0,09850081 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,05834248 0,09843279 ! cerebellar cortex development GO:0021695 16 10 0,000 0,05834248 0,09836485 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,05834248 0,09829702 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,05834248 0,09822927 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,05834248 0,09816162 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,05834248 0,09809406 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,05971516 0,10033296 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,05971516 0,100264 ! activation of MAPK activity GO:0000187 124 67 1,000 0,06131656 0,10288211 ! chromosome segregation GO:0007059 127 67 1,000 0,06131656 0,1028115 ! secondary metabolic process GO:0019748 125 67 1,000 0,06131656 0,10274099 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,06293256 0,10537646 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,06293256 0,10530428 ! viral reproduction GO:0016032 142 68 1,000 0,06293256 0,1052322 ! regulation of lipase activity GO:0060191 137 68 1,000 0,06293256 0,10516023 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,06398702 0,10684913 ! respiratory burst GO:0045730 17 11 0,000 0,06398702 0,10677615 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,06398702 0,10670326 ! neuron fate specification GO:0048665 18 11 0,000 0,06398702 0,10663048 ! telencephalon cell migration GO:0022029 23 11 0,000 0,06398702 0,10655779 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,06398702 0,10648521 ! thyroid gland development GO:0030878 26 11 0,000 0,06398702 0,10641272 ! synapsis GO:0007129 14 11 0,000 0,06398702 0,10634033 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,06398702 0,10626804 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,06398702 0,10619584 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,06398702 0,10612375 ! response to pain GO:0048265 27 11 0,000 0,06398702 0,10605175 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,06398702 0,10597985 ! blood vessel remodeling GO:0001974 30 11 0,000 0,06398702 0,10590805 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,06398702 0,10583635 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,06398702 0,10576474 ! bone resorption GO:0045453 16 11 0,000 0,06398702 0,10569323 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,06398702 0,10562181 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06398702 0,10555049 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06398702 0,10547927 ! melanocyte differentiation GO:0030318 20 11 0,000 0,06398702 0,10540815 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,06398702 0,10533712 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,06398702 0,10526618 ! L-serine metabolic process GO:0006563 21 11 0,000 0,06398702 0,10519534 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,06398702 0,1051246 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,06398702 0,10505395 ! UV protection GO:0009650 20 11 0,000 0,06398702 0,1049834 ! adult heart development GO:0007512 16 11 0,000 0,06398702 0,10491294 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06398702 0,10484258 ! macroautophagy GO:0016236 19 11 0,000 0,06398702 0,10477231 ! temperature homeostasis GO:0001659 18 11 0,000 0,06398702 0,10470213 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,06398702 0,10463205 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,06398702 0,10456206 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,06398702 0,10449217 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,06398702 0,10442237 ! regulation of organ growth GO:0046620 14 11 0,000 0,06398702 0,10435266 ! pigment granule localization GO:0051875 20 11 0,000 0,06398702 0,10428304 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,06398702 0,10421352 ! vasoconstriction GO:0042310 20 11 0,000 0,06398702 0,10414409 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,06398702 0,10407476 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06398702 0,10400551 ! embryonic axis specification GO:0000578 19 11 0,000 0,06398702 0,10393636 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,06398702 0,1038673 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06398702 0,10379833 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,06398702 0,10372945 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,06398702 0,10366066 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,06398702 0,10359197 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,06398702 0,10352337 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,06398702 0,10345485 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,06398702 0,10338643 ! prophase GO:0051324 17 11 0,000 0,06398702 0,1033181 ! nucleosome positioning GO:0016584 15 11 0,000 0,06398702 0,10324986 ! regulation of isotype switching GO:0045191 24 11 0,000 0,06398702 0,1031817 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,06398702 0,10311364 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,06398702 0,10304567 ! acid secretion GO:0046717 20 11 0,000 0,06398702 0,10297779 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06398702 0,10290999 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,06398702 0,10284229 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,06398702 0,10277468 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,06398702 0,10270715 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,06398702 0,10263971 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,06398702 0,10257236 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,06398702 0,1025051 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06398702 0,10243793 ! germ cell migration GO:0008354 26 11 0,000 0,06398702 0,10237085 ! embryonic gut development GO:0048566 19 11 0,000 0,06398702 0,10230385 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,06398702 0,10223694 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,06398702 0,10217012 ! activation of innate immune response GO:0002218 16 11 0,000 0,06398702 0,10210338 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,06398702 0,10203674 ! lysogeny GO:0030069 22 11 0,000 0,06398702 0,10197018 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06398702 0,1019037 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,06398702 0,10183732 ! nucleus localization GO:0051647 22 11 0,000 0,06398702 0,10177102 ! developmental maturation GO:0021700 128 69 1,000 0,06456293 0,10262019 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,06786584 0,1077999 ! carbohydrate transport GO:0008643 114 72 1,000 0,06953794 0,11038414 ! B cell activation GO:0042113 179 72 1,000 0,06953794 0,11031246 ! coenzyme biosynthetic process GO:0009108 119 72 1,000 0,06953794 0,11024087 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,06953794 0,11016938 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,06959788 0,11019288 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,06959788 0,11012151 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,06959788 0,11005024 ! mating GO:0007618 17 12 0,000 0,06959788 0,10997905 ! protein complex disassembly GO:0043241 28 12 0,000 0,06959788 0,10990796 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06959788 0,10983696 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,06959788 0,10976605 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,06959788 0,10969524 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,06959788 0,10962451 ! T cell proliferation GO:0042098 32 12 0,000 0,06959788 0,10955388 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06959788 0,10948333 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,06959788 0,10941288 ! ventral spinal cord development GO:0021517 25 12 0,000 0,06959788 0,10934252 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,06959788 0,10927225 ! drug transport GO:0015893 16 12 0,000 0,06959788 0,10920207 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,06959788 0,10913198 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,06959788 0,10906197 ! polyamine metabolic process GO:0006595 18 12 0,000 0,06959788 0,10899206 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,06959788 0,10892224 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,06959788 0,10885251 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,06959788 0,10878287 ! lipid digestion GO:0044241 21 12 0,000 0,06959788 0,10871331 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,06959788 0,10864385 ! entry into host cell GO:0030260 34 12 0,000 0,06959788 0,10857447 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06959788 0,10850518 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,06959788 0,10843598 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,06959788 0,10836687 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06959788 0,10829785 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,06959788 0,10822891 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,06959788 0,10816006 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,06959788 0,1080913 ! snRNA metabolic process GO:0016073 30 12 0,000 0,06959788 0,10802263 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,06959788 0,10795404 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,06959788 0,10788554 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06959788 0,10781713 ! fucose catabolic process GO:0019317 25 12 0,000 0,06959788 0,10774881 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,06959788 0,10768057 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,06959788 0,10761242 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,06959788 0,10754435 ! zymogen activation GO:0031638 18 12 0,000 0,06959788 0,10747637 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,06959788 0,10740848 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,06959788 0,10734067 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,06959788 0,10727295 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,06959788 0,10720531 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,06959788 0,10713776 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,06959788 0,10707029 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,06959788 0,10700291 ! defense response to fungus GO:0050832 15 12 0,000 0,06959788 0,10693561 ! lamellipodium assembly GO:0030032 24 12 0,000 0,06959788 0,1068684 ! response to cold GO:0009409 17 12 0,000 0,06959788 0,10680127 ! establishment of cell polarity GO:0030010 21 12 0,000 0,06959788 0,10673422 ! regulation of synapse organization GO:0050807 18 12 0,000 0,06959788 0,10666726 ! humoral immune response GO:0006959 115 73 1,000 0,0712235 0,10909029 ! amino acid transport GO:0006865 148 74 1,000 0,07292231 0,1116223 ! regulation of caspase activity GO:0043281 136 74 1,000 0,07292231 0,11155241 ! organelle localization GO:0051640 155 74 1,000 0,07292231 0,1114826 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,07463414 0,11402827 GO:0090046|regulation of transcription regulator activity, ! axon guidance GO:0007411 162 75 1,000 0,07463414 0,11395701 ! rhythmic process GO:0048511 142 75 1,000 0,07463414 0,11388583 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,07517526 0,11463993 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07517526 0,11456842 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,07517526 0,11449699 ! regulation of chemokine production GO:0032642 18 13 0,000 0,07517526 0,11442565 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,07517526 0,1143544 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,07517526 0,11428324 ! peroxisomal transport GO:0043574 28 13 0,000 0,07517526 0,11421217 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,07517526 0,11414119 ! cartilage condensation GO:0001502 22 13 0,000 0,07517526 0,11407029 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,07517526 0,11399949 ! organelle fusion GO:0048284 36 13 0,000 0,07517526 0,11392877 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,07517526 0,11385813 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,07517526 0,11378759 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,07517526 0,11371713 ! endocrine pancreas development GO:0031018 25 13 0,000 0,07517526 0,11364676 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,07517526 0,11357648 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,07517526 0,11350629 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,07517526 0,11343618 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,07517526 0,11336615 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,07517526 0,11329622 ! methionine metabolic process GO:0006555 31 13 0,000 0,07517526 0,11322637 ! plasma membrane organization GO:0007009 27 13 0,000 0,07517526 0,11315661 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,07517526 0,11308693 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,07517526 0,11301734 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,07517526 0,11294783 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,07517526 0,11287841 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,07517526 0,11280907 ! cytokine metabolic process GO:0042107 24 13 0,000 0,07517526 0,11273982 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,07517526 0,11267066 ! exocrine system development GO:0035272 34 13 0,000 0,07517526 0,11260158 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,07517526 0,11253258 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,07517526 0,11246367 ! L-glutamate transport GO:0015813 30 13 0,000 0,07517526 0,11239484 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,07517526 0,1123261 ! protein homotetramerization GO:0051289 24 13 0,000 0,07517526 0,11225744 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,07517526 0,11218886 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,07517526 0,11212037 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,07517526 0,11205196 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,07517526 0,11198364 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,07517526 0,1119154 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07517526 0,11184724 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,07517526 0,11177917 ! histone methylation GO:0016571 29 13 0,000 0,07517526 0,11171117 ! chromatin silencing GO:0006342 29 13 0,000 0,07517526 0,11164326 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,07517526 0,11157544 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,07517526 0,11150769 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07517526 0,11144003 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,07517526 0,11137245 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,07517526 0,11130495 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,07517526 0,11123754 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,07517526 0,1111702 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,07517526 0,11110295 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,07517526 0,11103577 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,07517526 0,11096868 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,07517526 0,11090167 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,07517526 0,11083474 ! insulin secretion GO:0030073 24 13 0,000 0,07517526 0,1107679 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,07517526 0,11070113 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,07517526 0,11063444 ! acrosome reaction GO:0007340 19 13 0,000 0,07517526 0,11056783 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,07517526 0,11050131 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,07517526 0,11043486 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,07809603 0,11465661 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,07809603 0,11458775 ! rRNA transcription GO:0009303 28 14 0,000 0,08071937 0,1183658 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,08071937 0,1182948 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,08071937 0,11822388 ! water transport GO:0006833 21 14 0,000 0,08071937 0,11815304 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,08071937 0,11808229 ! non-recombinational repair GO:0000726 29 14 0,000 0,08071937 0,11801162 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,08071937 0,11794104 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,08071937 0,11787055 ! RNA polyadenylation GO:0043631 32 14 0,000 0,08071937 0,11780013 ! lipid localization GO:0010876 32 14 0,000 0,08071937 0,11772981 GO:0019915|lipid storage, ! regulated secretory pathway GO:0045055 24 14 0,000 0,08071937 0,11765956 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,08071937 0,1175894 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,08071937 0,11751932 ! arginine metabolic process GO:0006525 21 14 0,000 0,08071937 0,11744933 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,08071937 0,11737942 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,08071937 0,11730959 ! regulation of heart rate GO:0002027 25 14 0,000 0,08071937 0,11723985 ! organic alcohol transport GO:0015850 29 14 0,000 0,08071937 0,11717019 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,08071937 0,11710061 ! embryo implantation GO:0007566 30 14 0,000 0,08071937 0,11703111 ! neutral amino acid transport GO:0015804 28 14 0,000 0,08071937 0,1169617 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,08071937 0,11689237 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,08071937 0,11682312 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,08071937 0,11675395 ! regulation of cellular pH GO:0030641 27 14 0,000 0,08071937 0,11668487 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,08071937 0,11661586 ! ribosome assembly GO:0042255 18 14 0,000 0,08071937 0,11654694 ! cerebellum development GO:0021549 23 14 0,000 0,08071937 0,1164781 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,08071937 0,11640934 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,08071937 0,11634066 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,08071937 0,11627207 ! NADP metabolic process GO:0006739 24 14 0,000 0,08071937 0,11620355 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,08071937 0,11613511 ! oxygen transport GO:0015671 22 14 0,000 0,08071937 0,11606676 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,08071937 0,11599848 ! male genitalia development GO:0030539 26 14 0,000 0,08071937 0,11593029 ! regulation of RNA stability GO:0043487 33 14 0,000 0,08071937 0,11586218 ! regulation of axon extension GO:0030516 43 14 0,000 0,08071937 0,11579414 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,08071937 0,11572619 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,08071937 0,11565831 ! protein oligomerization GO:0051259 149 79 1,000 0,08160747 0,11686228 ! muscle cell differentiation GO:0042692 178 81 1,000 0,0851668 0,12188781 ! lactation GO:0007595 30 15 0,000 0,0862304 0,12333774 ! reproductive cellular process GO:0048610 22 15 0,000 0,0862304 0,12326557 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,0862304 0,12319349 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,0862304 0,12312149 ! superoxide anion generation GO:0042554 22 15 0,000 0,0862304 0,12304957 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,0862304 0,12297774 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,0862304 0,12290599 ! copper ion transport GO:0006825 22 15 0,000 0,0862304 0,12283432 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,0862304 0,12276274 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,0862304 0,12269124 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,0862304 0,12261983 ! sulfate transport GO:0008272 27 15 0,000 0,0862304 0,12254849 ! response to cAMP GO:0051591 25 15 0,000 0,0862304 0,12247725 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,0862304 0,12240608 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,0862304 0,122335 ! response to hexose stimulus GO:0009746 25 15 0,000 0,0862304 0,12226399 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,0862304 0,12219308 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,0862304 0,12212224 ! vesicle coating GO:0006901 38 15 0,000 0,0862304 0,12205148 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,0862304 0,12198081 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,0862304 0,12191022 ! regulation of exocytosis GO:0017157 26 15 0,000 0,0862304 0,12183971 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,0862304 0,12176928 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,0862304 0,12169894 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,0862304 0,12162867 ! regulation of vasodilation GO:0042312 27 15 0,000 0,0862304 0,12155849 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,0862304 0,12148839 ! histone deacetylation GO:0016575 24 15 0,000 0,0862304 0,12141836 ! water homeostasis GO:0030104 28 15 0,000 0,0862304 0,12134842 ! cofactor transport GO:0051181 30 15 0,000 0,0862304 0,12127856 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,0862304 0,12120878 ! muscle maintenance GO:0046716 26 15 0,000 0,0862304 0,12113908 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,0862304 0,12106946 ! intestinal absorption GO:0050892 31 15 0,000 0,0862304 0,12099992 ! dopamine metabolic process GO:0042417 35 15 0,000 0,0862304 0,12093046 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,0862304 0,12086108 ! heme biosynthetic process GO:0006783 33 15 0,000 0,0862304 0,12079178 ! cell killing GO:0001906 32 15 0,000 0,0862304 0,12072256 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,0862304 0,12065341 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,0862304 0,12058435 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,0862304 0,12051537 ! actin filament polymerization GO:0030041 27 15 0,000 0,0862304 0,12044646 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,0862304 0,12037764 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,08696391 0,12133229 ! response to drug GO:0042493 149 83 1,000 0,08877238 0,12378478 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,08877238 0,12371416 ! positive regulation of cell size GO:0045793 29 16 0,000 0,09170854 0,12773316 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,09170854 0,12766038 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,09170854 0,12758768 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,09170854 0,12751506 ! bone remodeling GO:0046849 28 16 0,000 0,09170854 0,12744253 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09170854 0,12737008 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,09170854 0,12729771 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,09170854 0,12722542 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,09170854 0,12715321 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,09170854 0,12708109 ! startle response GO:0001964 28 16 0,000 0,09170854 0,12700905 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,09170854 0,12693709 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,09170854 0,12686521 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,09170854 0,12679341 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,09170854 0,1267217 ! protein polyubiquitination GO:0000209 41 16 0,000 0,09170854 0,12665006 ! pituitary gland development GO:0021983 30 16 0,000 0,09170854 0,12657851 ! response to osmotic stress GO:0006970 27 16 0,000 0,09170854 0,12650704 ! lysosomal transport GO:0007041 31 16 0,000 0,09170854 0,12643565 ! fructose metabolic process GO:0006000 25 16 0,000 0,09170854 0,12636433 ! L-amino acid transport GO:0015807 33 16 0,000 0,09170854 0,1262931 ! stem cell development GO:0048864 46 16 0,000 0,09170854 0,12622195 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,09170854 0,12615088 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,09170854 0,12607989 ! intermediate filament-based process GO:0045103 36 16 0,000 0,09170854 0,12600898 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,09170854 0,12593815 ! negative regulation of immune response GO:0050777 38 16 0,000 0,09170854 0,1258674 ! axon cargo transport GO:0008088 46 16 0,000 0,09170854 0,12579672 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,09170854 0,12572613 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,09170854 0,12565562 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,09170854 0,12558518 ! DNA replication initiation GO:0006270 28 16 0,000 0,09170854 0,12551483 ! neuron recognition GO:0008038 40 16 0,000 0,09170854 0,12544455 ! mRNA splice site selection GO:0006376 44 16 0,000 0,09170854 0,12537435 ! tissue regeneration GO:0042246 27 16 0,000 0,09170854 0,12530423 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,09170854 0,12523419 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,09170854 0,12516423 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,09170854 0,12509434 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,09170854 0,12502453 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,09170854 0,1249548 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,09170854 0,12488515 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,09170854 0,12481558 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,09170854 0,12474608 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,09170854 0,12467666 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,09170854 0,12460732 ! peptide hormone processing GO:0016486 27 16 0,000 0,09170854 0,12453806 ! regulation of protein transport GO:0051223 165 87 1,000 0,09611593 0,13045068 GO:0070201|regulation of establishment of protein localization, ! positive regulation of cell killing GO:0031343 36 17 0,000 0,09715399 0,13178635 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,09715399 0,13171321 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,09715399 0,13164016 ! filopodium assembly GO:0046847 42 17 0,000 0,09715399 0,13156719 ! endothelial cell migration GO:0043542 31 17 0,000 0,09715399 0,1314943 ! gene silencing by RNA GO:0031047 38 17 0,000 0,09715399 0,13142149 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,09715399 0,13134876 ! glial cell development GO:0021782 28 17 0,000 0,09715399 0,13127611 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,09715399 0,13120354 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,09715399 0,13113105 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,09715399 0,13105865 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,09715399 0,13098632 ! myoblast differentiation GO:0045445 50 17 0,000 0,09715399 0,13091407 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,09715399 0,1308419 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,09715399 0,13076981 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,09715399 0,1306978 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,09715399 0,13062587 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,09715399 0,13055402 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,09715399 0,13048225 ! membrane budding GO:0006900 42 17 0,000 0,09715399 0,13041055 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,09715399 0,13033894 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,09715399 0,1302674 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,09715399 0,13019594 ! genitalia development GO:0048806 32 17 0,000 0,09715399 0,13012457 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,09715399 0,13005326 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,09715399 0,12998204 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,09715399 0,1299109 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,09715399 0,12983983 ! steroid catabolic process GO:0006706 34 17 0,000 0,09715399 0,12976884 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,09715399 0,12969793 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,09715399 0,12962709 ! gas transport GO:0015669 26 17 0,000 0,09715399 0,12955634 ! organic cation transport GO:0015695 32 17 0,000 0,09715399 0,12948566 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,09715399 0,12941505 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,09715399 0,12934453 ! cellular respiration GO:0045333 143 88 1,000 0,09797826 0,13037086 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,09797826 0,13029989 ! regulation of DNA binding GO:0051101 167 89 1,000 0,09985079 0,13271789 ! response to unfolded protein GO:0006986 139 90 1,000 0,10173332 0,13514655 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,10256695 0,13617993 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,10256695 0,13610596 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,10256695 0,13603207 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,10256695 0,13595826 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,10256695 0,13588453 ! adult walking behavior GO:0007628 36 18 0,000 0,10256695 0,13581088 ! heart looping GO:0001947 34 18 0,000 0,10256695 0,13573731 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,10256695 0,13566382 ! centrosome cycle GO:0007098 26 18 0,000 0,10256695 0,1355904 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,10256695 0,13551707 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,10256695 0,13544382 ! glycine metabolic process GO:0006544 30 18 0,000 0,10256695 0,13537065 ! glutamine metabolic process GO:0006541 29 18 0,000 0,10256695 0,13529755 ! response to retinoic acid GO:0032526 31 18 0,000 0,10256695 0,13522454 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,10256695 0,1351516 ! DNA integration GO:0015074 32 18 0,000 0,10256695 0,13507874 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,10256695 0,13500596 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,10256695 0,13493326 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,10256695 0,13486064 ! neural crest cell migration GO:0001755 41 18 0,000 0,10256695 0,13478809 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,10256695 0,13471563 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,10256695 0,13464324 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,10256695 0,13457093 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,10256695 0,13449869 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,10256695 0,13442654 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,10256695 0,13435446 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,10256695 0,13428246 ! detection of bacterium GO:0016045 22 18 0,000 0,10256695 0,13421053 ! microspike assembly GO:0030035 46 18 0,000 0,10256695 0,13413869 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,10256695 0,13406692 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,10256695 0,13399522 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,10743913 0,1402853 ! amine transport GO:0015837 181 93 1,000 0,10743913 0,14021036 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,10794761 0,14079873 ! positive regulation of translation GO:0045727 31 19 0,000 0,10794761 0,14072359 ! negative regulation of defense response GO:0031348 27 19 0,000 0,10794761 0,14064854 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,10794761 0,14057357 ! neuron maturation GO:0042551 46 19 0,000 0,10794761 0,14049868 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,10794761 0,14042386 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,10794761 0,14034913 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,10794761 0,14027448 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,10794761 0,1401999 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,10794761 0,14012541 ! inositol metabolic process GO:0006020 33 19 0,000 0,10794761 0,14005099 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,10794761 0,13997665 ! memory GO:0007613 34 19 0,000 0,10794761 0,13990239 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,10794761 0,13982821 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,10794761 0,13975411 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,10794761 0,13968009 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,10794761 0,13960615 ! cerebral cortex development GO:0021987 40 19 0,000 0,10794761 0,13953228 ! pigmentation during development GO:0048066 42 19 0,000 0,10794761 0,13945849 ! response to vitamin A GO:0033189 32 19 0,000 0,10794761 0,13938478 ! heme metabolic process GO:0042168 40 19 0,000 0,10794761 0,13931115 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,10794761 0,1392376 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,10794761 0,13916412 ! response to fungus GO:0009620 26 19 0,000 0,10794761 0,13909072 ! peptide cross-linking GO:0018149 39 19 0,000 0,10794761 0,1390174 ! protein export from nucleus GO:0006611 40 19 0,000 0,10794761 0,13894416 ! heart process GO:0003015 32 19 0,000 0,10794761 0,13887099 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,10794761 0,1387979 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,10794761 0,13872489 ! visual learning GO:0008542 38 19 0,000 0,10794761 0,13865195 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,10794761 0,13857909 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,10794761 0,13850631 ! vitamin transport GO:0051180 31 19 0,000 0,10794761 0,1384336 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,10794761 0,13836097 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,10794761 0,13828842 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,10794761 0,13821594 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,10794761 0,13814354 ! cilium assembly GO:0042384 38 19 0,000 0,10794761 0,13807121 ! peptide hormone secretion GO:0030072 32 19 0,000 0,10794761 0,13799896 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,10935986 0,13973125 ! cofactor biosynthetic process GO:0051188 161 95 1,000 0,11128969 0,14212269 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,11128969 0,14204844 ! protein secretion GO:0009306 45 20 0,000 0,11329616 0,14453395 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,11329616 0,14445852 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,11329616 0,14438316 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,11329616 0,14430788 ! skin development GO:0043588 42 20 0,000 0,11329616 0,14423268 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,11329616 0,14415756 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,11329616 0,14408252 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,11329616 0,14400755 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,11329616 0,14393267 ! response to vitamin GO:0033273 36 20 0,000 0,11329616 0,14385786 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,11329616 0,14378312 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,11329616 0,14370847 ! bile acid metabolic process GO:0008206 34 20 0,000 0,11329616 0,14363389 ! retinoid metabolic process GO:0001523 34 20 0,000 0,11329616 0,1435594 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,11329616 0,14348497 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,11329616 0,14341063 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,11329616 0,14333636 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,11329616 0,14326217 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,11329616 0,14318806 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,11329616 0,14311402 ! peptide secretion GO:0002790 38 20 0,000 0,11329616 0,14304006 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,11329616 0,14296618 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,11329616 0,14289237 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,11329616 0,14281864 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,11329616 0,14274498 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,11329616 0,1426714 ! cell-cell junction organization GO:0045216 43 20 0,000 0,11329616 0,1425979 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,11329616 0,14252447 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,11329616 0,14245111 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,11329616 0,14237784 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,11329616 0,14230464 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,11329616 0,14223151 ! negative regulation of translation GO:0017148 32 20 0,000 0,11329616 0,14215846 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,11329616 0,14208548 ! transcription initiation GO:0006352 171 97 1,000 0,11517593 0,14436881 ! regulation of cell killing GO:0031341 46 21 0,000 0,11861279 0,14860053 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,11861279 0,14852437 ! hormone secretion GO:0046879 39 21 0,000 0,11861279 0,14844828 ! cAMP metabolic process GO:0046058 41 21 0,000 0,11861279 0,14837227 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,11861279 0,14829634 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,11861279 0,14822048 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,11861279 0,1481447 ! smooth muscle contraction GO:0006939 48 21 0,000 0,11861279 0,148069 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,11861279 0,14799338 ! plasma membrane fusion GO:0045026 33 21 0,000 0,11861279 0,14791784 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,11861279 0,14784237 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,11861279 0,14776698 ! sensory perception of pain GO:0019233 33 21 0,000 0,11861279 0,14769166 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,11861279 0,14761642 ! diencephalon development GO:0021536 36 21 0,000 0,11861279 0,14754126 ! collagen fibril organization GO:0030199 62 21 0,000 0,11861279 0,14746618 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,11861279 0,14739117 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,11861279 0,14731624 ! collagen catabolic process GO:0030574 29 21 0,000 0,11861279 0,14724138 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,11861279 0,1471666 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,11861279 0,1470919 ! actin filament-based movement GO:0030048 47 21 0,000 0,11861279 0,14701727 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,11861279 0,14694272 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,12389769 0,15341209 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,12389769 0,15333437 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,12389769 0,15325673 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,12389769 0,15317917 ! microtubule-based transport GO:0010970 59 22 0,000 0,12389769 0,15310169 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,12389769 0,15302429 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,12389769 0,15294697 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,12389769 0,15286972 ! cellular response to starvation GO:0009267 37 22 0,000 0,12389769 0,15279255 ! vacuolar transport GO:0007034 41 22 0,000 0,12389769 0,15271546 ! fucose metabolic process GO:0006004 44 22 0,000 0,12389769 0,15263845 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,12389769 0,15256152 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,12389769 0,15248466 ! stem cell differentiation GO:0048863 57 22 0,000 0,12389769 0,15240788 ! cytolysis GO:0019835 27 22 0,000 0,12389769 0,15233118 ! vasodilation GO:0042311 40 22 0,000 0,12389769 0,15225455 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,12389769 0,152178 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,12389769 0,15210153 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,12389769 0,15202514 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,12389769 0,15194882 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,12389769 0,15187258 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,12389769 0,15179641 ! sarcomere organization GO:0045214 32 22 0,000 0,12389769 0,15172032 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,12389769 0,15164431 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,12389769 0,15156838 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,12389769 0,15149252 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,12389769 0,15141673 ! protein stabilization GO:0050821 41 22 0,000 0,12389769 0,15134102 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,12915104 0,15767916 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,12915104 0,1576004 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,12915104 0,15752172 ! glycerol metabolic process GO:0006071 40 23 0,000 0,12915104 0,15744311 ! viral genome replication GO:0019079 44 23 0,000 0,12915104 0,15736459 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,12915104 0,15728614 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,12915104 0,15720777 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,12915104 0,15712948 ! axis specification GO:0009798 43 23 0,000 0,12915104 0,15705127 ! visual behavior GO:0007632 46 23 0,000 0,12915104 0,15697314 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,12915104 0,15689508 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,12915104 0,1568171 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,12915104 0,1567392 ! peroxisome organization GO:0007031 43 23 0,000 0,12915104 0,15666137 ! lysosome organization GO:0007040 47 23 0,000 0,12915104 0,15658362 ! vesicle targeting GO:0006903 49 23 0,000 0,12915104 0,15650595 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,12915104 0,15642836 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,12915104 0,15635084 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,12915104 0,1562734 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,12915104 0,15619604 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,12915104 0,15611875 ! DNA modification GO:0006304 36 23 0,000 0,12915104 0,15604154 ! fatty acid transport GO:0015908 47 23 0,000 0,12915104 0,15596441 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,12915104 0,15588735 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,12915104 0,15581037 ! hormone transport GO:0009914 41 23 0,000 0,12915104 0,15573347 ! cell-cell recognition GO:0009988 28 23 0,000 0,12915104 0,15565664 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,12915104 0,15557988 ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,12915104 0,1555032 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,13437305 0,16171101 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,13437305 0,16163139 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,13437305 0,16155185 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,13437305 0,16147239 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,13437305 0,161393 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,13437305 0,16131369 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,13437305 0,16123446 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,13437305 0,16115531 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,13437305 0,16107623 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,13437305 0,16099723 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,13437305 0,16091831 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,13437305 0,16083947 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,13437305 0,16076071 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,13437305 0,16068202 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,13437305 0,1606034 ! membrane depolarization GO:0051899 45 24 0,000 0,13437305 0,16052487 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,13437305 0,16044641 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,13437305 0,16036803 ! platelet activation GO:0030168 41 24 0,000 0,13437305 0,16028973 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,13437305 0,1602115 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,13437305 0,16013335 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,13437305 0,16005527 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,13437305 0,15997727 ! regulation of amine transport GO:0051952 41 24 0,000 0,13437305 0,15989935 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,13437305 0,1598215 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,13956389 0,16591464 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,13956389 0,16583394 ! leukocyte adhesion GO:0007159 55 25 0,000 0,13956389 0,16575332 ! keratinization GO:0031424 37 25 0,000 0,13956389 0,16567278 ! vacuole organization GO:0007033 49 25 0,000 0,13956389 0,16559231 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,13956389 0,16551193 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,13956389 0,16543162 ! receptor metabolic process GO:0043112 53 25 0,000 0,13956389 0,16535139 ! chromosome condensation GO:0030261 48 25 0,000 0,13956389 0,16527124 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,13956389 0,16519117 ! immunoglobulin production GO:0002377 62 25 0,000 0,13956389 0,16511117 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,13956389 0,16503126 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,13956389 0,16495142 ! liver development GO:0001889 55 25 0,000 0,13956389 0,16487165 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,14472374 0,17088453 ! initiation of viral infection GO:0019059 60 26 0,000 0,14472374 0,17080198 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,14472374 0,17071951 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,14472374 0,17063711 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,14472374 0,1705548 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,14472374 0,17047257 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,14472374 0,17039041 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,14472374 0,17030833 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,14472374 0,17022634 ! digestive system process GO:0022600 49 26 0,000 0,14472374 0,17014442 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,14472374 0,17006258 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,14472374 0,16998082 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,14472374 0,16989914 ! neural crest cell development GO:0014032 59 26 0,000 0,14472374 0,16981753 GO:0014033|neural crest cell differentiation, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,14472374 0,16973601 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,14472374 0,16965456 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,14472374 0,16957319 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,14472374 0,1694919 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,14472374 0,16941069 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,14472374 0,16932955 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,14472374 0,16924849 ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,14472374 0,16916751 ! neural tube closure GO:0001843 58 26 0,000 0,14472374 0,16908661 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,14472374 0,16900578 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,14472374 0,16892504 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,14472374 0,16884437 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,1498528 0,17474481 ! embryonic pattern specification GO:0009880 49 27 0,000 0,1498528 0,17466144 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,1498528 0,17457815 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,1498528 0,17449494 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,1498528 0,17441181 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,1498528 0,17432876 ! iron ion transport GO:0006826 65 27 0,000 0,1498528 0,17424578 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,1498528 0,17416289 ! superoxide metabolic process GO:0006801 41 27 0,000 0,1498528 0,17408007 ! tube lumen formation GO:0035148 59 27 0,000 0,1498528 0,17399733 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,1498528 0,17391467 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,1498528 0,17383209 ! response to starvation GO:0042594 47 27 0,000 0,1498528 0,17374959 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,1498528 0,17366717 ! neuron fate commitment GO:0048663 52 28 0,000 0,15495124 0,1794907 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,15495124 0,17940563 ! vesicle docking GO:0048278 55 28 0,000 0,15495124 0,17932064 ! circadian rhythm GO:0007623 56 28 0,000 0,15495124 0,17923574 ! fat cell differentiation GO:0045444 57 28 0,000 0,15495124 0,17915091 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,15495124 0,17906617 ! sperm motility GO:0030317 37 28 0,000 0,15495124 0,1789815 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,15495124 0,17889692 ! base-excision repair GO:0006284 41 28 0,000 0,15495124 0,17881241 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,15495124 0,17872799 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,15495124 0,17864364 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,15495124 0,17855938 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,15495124 0,17847519 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,15495124 0,17839108 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,15495124 0,17830706 ! lipid oxidation GO:0034440 48 28 0,000 0,15495124 0,17822311 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,15495124 0,17813924 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,16001925 0,18387913 ! translational initiation GO:0006413 66 29 0,000 0,16001925 0,18379268 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,16001925 0,18370631 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,16001925 0,18362002 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,16001925 0,18353381 ! autophagy GO:0006914 47 29 0,000 0,16001925 0,18344769 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,16001925 0,18336164 ! primary neural tube formation GO:0014020 61 29 0,000 0,16001925 0,18327568 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,16001925 0,1831898 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,16001925 0,18310399 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,16001925 0,18301827 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,16001925 0,18293263 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,165057 0,18860349 ! phenol metabolic process GO:0018958 56 30 0,000 0,165057 0,18851532 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,165057 0,18842723 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,165057 0,18833922 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,165057 0,18825129 ! sensory perception of taste GO:0050909 41 30 0,000 0,165057 0,18816344 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,165057 0,18807568 ! acute-phase response GO:0006953 50 30 0,000 0,165057 0,187988 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,165057 0,1879004 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,165057 0,18781288 ! myofibril assembly GO:0030239 50 30 0,000 0,165057 0,18772545 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,165057 0,18763809 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,165057 0,18755082 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,165057 0,18746363 ! cell fate determination GO:0001709 64 30 0,000 0,165057 0,18737652 ! phospholipid transport GO:0015914 65 30 0,000 0,165057 0,18728949 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,165057 0,18720254 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,165057 0,18711567 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,165057 0,18702888 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,165057 0,18694217 GO:0043433|negative regulation of transcription factor activity, ! regulation of coagulation GO:0050818 52 30 0,000 0,165057 0,18685554 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,17006469 0,1924354 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,17006469 0,19234631 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,17006469 0,1922573 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,17006469 0,19216838 ! regulation of innate immune response GO:0045088 57 31 0,000 0,17006469 0,19207953 ! peptide transport GO:0015833 60 31 0,000 0,17006469 0,19199077 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,17006469 0,19190209 ! natural killer cell activation GO:0030101 50 31 0,000 0,17006469 0,1918135 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,17006469 0,19172498 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,17006469 0,19163655 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,17504248 0,1971548 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,17504248 0,19706395 ! collagen metabolic process GO:0032963 49 32 0,000 0,17504248 0,19697318 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,17504248 0,19688249 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,17504248 0,19679189 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,17504248 0,19670137 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,17504248 0,19661093 ! muscle cell development GO:0055001 52 32 0,000 0,17504248 0,19652057 ! mesoderm formation GO:0001707 73 32 0,000 0,17504248 0,1964303 ! gene silencing GO:0016458 71 32 0,000 0,17504248 0,19634012 ! regulation of pH GO:0006885 56 33 0,000 0,17999055 0,20179757 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,17999055 0,20170501 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,17999055 0,20161252 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,17999055 0,20152012 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,17999055 0,20142781 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,17999055 0,20133558 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,17999055 0,20124344 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,17999055 0,20115138 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,17999055 0,2010594 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,17999055 0,20096751 ! glial cell differentiation GO:0010001 67 34 0,000 0,18490908 0,20636496 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,18490908 0,20627072 ! cholesterol transport GO:0030301 62 34 0,000 0,18490908 0,20617658 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,18490908 0,20608252 ! spliceosome assembly GO:0000245 75 34 0,000 0,18490908 0,20598855 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,18490908 0,20589466 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,18490908 0,20580086 ! formation of primary germ layer GO:0001704 76 34 0,000 0,18490908 0,20570714 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,18490908 0,20561351 ! adult locomotory behavior GO:0008344 62 34 0,000 0,18490908 0,20551997 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,18979825 0,21085817 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,18979825 0,21076233 ! negative regulation of secretion GO:0051048 68 35 0,000 0,18979825 0,21066657 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,18979825 0,2105709 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,18979825 0,21047532 ! membrane docking GO:0022406 69 35 0,000 0,18979825 0,21037982 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,18979825 0,21028441 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,18979825 0,21018909 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,18979825 0,21009385 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,18979825 0,2099987 ! ceramide metabolic process GO:0006672 72 35 0,000 0,18979825 0,20990363 ! sterol transport GO:0015918 63 35 0,000 0,18979825 0,20980865 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,18979825 0,20971376 ! vesicle localization GO:0051648 70 35 0,000 0,18979825 0,20961895 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,19465823 0,21488931 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,19465823 0,21479226 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,19465823 0,21469528 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,19465823 0,2145984 ! protein targeting to membrane GO:0006612 75 36 0,000 0,19465823 0,2145016 ! regulation of proteolysis GO:0030162 77 36 0,000 0,19465823 0,21440489 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,19465823 0,21430827 ! cytokine production GO:0001816 68 36 0,000 0,19465823 0,21421174 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,19465823 0,21411529 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,19948919 0,21933037 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,19948919 0,21923171 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,19948919 0,21913314 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,19948919 0,21903465 ! actomyosin structure organization GO:0031032 68 37 0,000 0,19948919 0,21893625 ! tissue remodeling GO:0048771 78 37 0,000 0,19948919 0,21883794 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,19948919 0,21873972 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,19948919 0,21864158 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,19948919 0,21854354 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,20429131 0,22370402 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,20429131 0,22360379 ! organic anion transport GO:0015711 82 38 0,000 0,20429131 0,22350366 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,20429131 0,22340361 ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,20429131 0,22330365 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,20429131 0,22320379 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,20429131 0,22310401 ! spermatid development GO:0007286 69 38 0,000 0,20429131 0,22300432 ! glycogen metabolic process GO:0005977 63 38 0,000 0,20429131 0,22290472 ! neural tube formation GO:0001841 79 38 0,000 0,20429131 0,22280521 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,20906475 0,2279095 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,20906475 0,22780785 ! negative regulation of binding GO:0051100 71 39 0,000 0,20906475 0,22770628 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,20906475 0,22760481 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,20906475 0,22750343 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,20906475 0,22740213 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,20906475 0,22730093 ! glucan metabolic process GO:0044042 64 39 0,000 0,20906475 0,22719982 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,2138097 0,23225304 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,2138097 0,23214982 ! lipid homeostasis GO:0055088 75 40 0,000 0,2138097 0,23204669 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,2138097 0,23194365 ! RNA export from nucleus GO:0006405 61 41 0,000 0,21852631 0,23695507 ! mRNA catabolic process GO:0006402 79 41 0,000 0,21852631 0,23684994 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,21852631 0,23674491 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,21852631 0,23663997 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,21852631 0,23653512 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,21852631 0,23643037 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,21852631 0,23632571 ! gliogenesis GO:0042063 91 41 0,000 0,21852631 0,23622114 ! feeding behavior GO:0007631 69 41 0,000 0,21852631 0,23611666 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,21852631 0,23601228 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,21852631 0,23590798 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,21852631 0,23580378 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,21852631 0,23569968 ! spermatid differentiation GO:0048515 73 41 0,000 0,21852631 0,23559566 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,21852631 0,23549174 ! RNA modification GO:0009451 64 41 0,000 0,21852631 0,23538791 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,22321475 0,24033215 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,22321475 0,24022627 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,22321475 0,24012049 ! regulation of protein secretion GO:0050708 77 42 0,000 0,22321475 0,24001481 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,22321475 0,23990921 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,2278752 0,24481052 ! regulation of tube size GO:0035150 76 43 0,000 0,2278752 0,24470291 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,2278752 0,2445954 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,2278752 0,24448798 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,2278752 0,24438065 ! ion transmembrane transport GO:0034220 79 43 0,000 0,2278752 0,24427342 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,23250782 0,24913009 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,23250782 0,24902087 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,23250782 0,24891175 ! striated muscle contraction GO:0006941 85 44 0,000 0,23250782 0,24880272 ! phagocytosis GO:0006909 105 44 0,000 0,23250782 0,24869379 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,23250782 0,24858495 ! double-strand break repair GO:0006302 85 44 0,000 0,23250782 0,24847621 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,23711277 0,25328662 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,23711277 0,25317592 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,23711277 0,25306532 ! biopolymer methylation GO:0043414 91 45 0,000 0,23711277 0,25295481 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,23711277 0,25284439 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,23711277 0,25273408 ! polyol metabolic process GO:0019751 77 45 0,000 0,23711277 0,25262386 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,24169023 0,2573885 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,24169023 0,25727635 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,24169023 0,2571643 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,24169023 0,25705234 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,24169023 0,25694048 ! neural tube development GO:0021915 91 47 0,000 0,24624034 0,26166383 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,25076328 0,26635422 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,25076328 0,26623846 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,25076328 0,2661228 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,25076328 0,26600725 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,25076328 0,2658918 ! methylation GO:0032259 97 48 0,000 0,25076328 0,26577644 ! response to calcium ion GO:0051592 94 49 0,000 0,25525921 0,27042422 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,25525921 0,270307 ! protein homooligomerization GO:0051260 84 49 0,000 0,25525921 0,27018988 ! regulation of ion transport GO:0043269 86 50 0,000 0,25972828 0,2748013 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,25972828 0,27468233 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,25972828 0,27456348 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,25972828 0,27444472 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,25972828 0,27432607 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,25972828 0,27420752 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,25972828 0,27408907 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,26417066 0,27865671 ! viral infectious cycle GO:0019058 104 51 0,000 0,26417066 0,27853644 ! Notch signaling pathway GO:0007219 111 52 0,000 0,26858651 0,28307025 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,26858651 0,28294819 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,26858651 0,28282623 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,26858651 0,28270437 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,26858651 0,28258262 ! excretion GO:0007588 87 52 0,000 0,26858651 0,28246097 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,26858651 0,28233943 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,26858651 0,282218 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,26858651 0,28209667 ! amino acid activation GO:0043038 98 52 0,000 0,26858651 0,28197544 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,27297598 0,28646062 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,27297598 0,28633762 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,27733923 0,29078959 ! neuromuscular process GO:0050905 107 54 0,000 0,27733923 0,29066484 ! membrane fusion GO:0006944 122 54 0,000 0,27733923 0,2905402 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,27733923 0,29041566 ! RNA catabolic process GO:0006401 103 55 0,000 0,28167642 0,29483097 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,28167642 0,29470471 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,28167642 0,29457855 ! cell recognition GO:0008037 98 55 0,000 0,28167642 0,2944525 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,28167642 0,29432656 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,28598769 0,29870369 ! RNA elongation GO:0006354 90 56 0,000 0,28598769 0,29857604 ! chloride transport GO:0006821 102 57 0,000 0,29027322 0,30292075 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,29027322 0,3027914 ! regulation of actin filament length GO:0030832 118 58 0,000 0,29453314 0,30710391 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,29453314 0,30697289 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,29453314 0,30684198 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,29453314 0,30671119 ! gastrulation GO:0007369 122 58 0,000 0,29453314 0,30658051 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,29453314 0,30644994 ! nuclear export GO:0051168 110 59 0,000 0,29876761 0,3107234 ! regulation of endocytosis GO:0030100 104 60 0,000 0,30297678 0,31496693 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,30297678 0,31483295 ! adult behavior GO:0030534 104 60 0,000 0,30297678 0,3146991 ! positive regulation of secretion GO:0051047 110 61 0,000 0,30716081 0,31890941 ! regulation of cellular component size GO:0032535 125 61 0,000 0,30716081 0,31877394 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,30716081 0,31863858 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,30716081 0,31850333 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,30716081 0,3183682 ! proton transport GO:0015992 117 61 0,000 0,30716081 0,31823319 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,31131983 0,32240541 ! tRNA processing GO:0008033 102 62 0,000 0,31131983 0,32226879 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,31545401 0,32641006 ! mesoderm development GO:0007498 128 63 0,000 0,31545401 0,32627187 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,31545401 0,32613379 ! hydrogen transport GO:0006818 121 64 0,000 0,31956349 0,33024264 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,31956349 0,330103 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,31956349 0,32996348 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,32364841 0,33404016 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,32364841 0,33389909 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,32364841 0,33375815 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,32770892 0,33780291 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,33174517 0,34181925 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,33174517 0,34167514 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,33174517 0,34153116 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,33575729 0,34551604 ! extracellular matrix organization GO:0030198 146 68 0,000 0,33575729 0,34537056 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,33575729 0,3452252 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! adaptive immune response GO:0002250 126 68 0,000 0,33575729 0,34507996 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 0,000 0,33575729 0,34493485 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,33974545 0,3488853 ! single fertilization GO:0007338 83 69 0,000 0,33974545 0,34873871 ! cell redox homeostasis GO:0045454 114 70 0,000 0,34370977 0,35265979 ! activation of immune response GO:0002253 120 70 0,000 0,34370977 0,35251174 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,34370977 0,35236381 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,34765039 0,35625416 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,34765039 0,35610478 ! appendage morphogenesis GO:0035107 150 72 0,000 0,35156747 0,35996619 GO:0035108|limb morphogenesis, ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,35156747 0,35981539 ! appendage development GO:0048736 151 73 0,000 0,35546114 0,36364806 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,35546114 0,36349584 ! regulation of immune effector process GO:0002697 156 73 0,000 0,35546114 0,36334375 ! acute inflammatory response GO:0002526 118 74 0,000 0,35933153 0,36714635 ! transition metal ion transport GO:0000041 143 75 0,000 0,36317879 0,37092215 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,36317879 0,37076715 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,36700306 0,37451482 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,36700306 0,37435844 ! regulation of blood pressure GO:0008217 134 76 0,000 0,36700306 0,3742022 ! neurotransmitter transport GO:0006836 142 77 0,000 0,37080447 0,37792045 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,37080447 0,37776285 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,37080447 0,37760538 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,37458315 0,38129444 ! antigen processing and presentation GO:0019882 117 78 0,000 0,37458315 0,38113563 ! fertilization GO:0009566 99 78 0,000 0,37458315 0,38097695 ! blood coagulation GO:0007596 151 79 0,000 0,37833925 0,38463703 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,37833925 0,38447704 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,37833925 0,38431717 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,37833925 0,38415744 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,38578422 0,39155416 ! protein import into nucleus GO:0006606 174 82 0,000 0,38947336 0,39513431 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,39314045 0,39868913 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,39314045 0,3985237 ! nuclear import GO:0051170 177 83 0,000 0,39314045 0,39835841 ! inorganic anion transport GO:0015698 156 83 0,000 0,39314045 0,39819325 ! digestion GO:0007586 130 84 0,000 0,39678561 0,40171871 ! hemostasis GO:0007599 165 85 0,000 0,40040898 0,4052192 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,40040898 0,4050514 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,40040898 0,40488375 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,40040898 0,40471623 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,40401069 0,4081878 ! regulation of lyase activity GO:0051339 169 86 0,000 0,40401069 0,40801906 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,40759086 0,41146465 ! nucleosome assembly GO:0006334 126 87 0,000 0,40759086 0,4112947 ! amine biosynthetic process GO:0009309 146 88 0,000 0,41114962 0,4147145 ! sensory perception of smell GO:0007608 117 88 0,000 0,41114962 0,41454335 ! chromatin assembly GO:0031497 128 88 0,000 0,41114962 0,41437233 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,41468711 0,4177652 ! cellular defense response GO:0006968 123 89 0,000 0,41468711 0,417593 ! protein localization in nucleus GO:0034504 192 89 0,000 0,41468711 0,41742093 ! regulation of neurological system process GO:0031644 175 89 0,000 0,41468711 0,41724902 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,41820344 0,42061384 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,42169875 0,42395475 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,42169875 0,42378036 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,42517316 0,42709623 ! vitamin metabolic process GO:0006766 153 93 0,000 0,42862679 0,43038851 ! sterol metabolic process GO:0016125 166 94 0,000 0,43205977 0,43365736 ! nucleosome organization GO:0034728 143 95 0,000 0,43547222 0,43690293 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,43547222 0,43672357 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,43547222 0,43654437 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,43547222 0,43636531 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,44223601 0,44296128 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,4455876 0,44613545 ! mRNA transport GO:0051028 185 100 0,000 0,45223075 0,45260128 ! positive regulation of immune response GO:0050778 175 100 0,000 0,45223075 0,45241594 ! hormone metabolic process GO:0042445 171 100 0,000 0,45223075 0,45223075