pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6418-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of positive chemotaxis GO:0050930 17 9 3,000 6,773E-09 1,655E-05 ! regulation of positive chemotaxis GO:0050926 22 12 3,000 2,644E-08 3,23E-05 GO:0050927|positive regulation of positive chemotaxis, ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 1,609E-07 1,31E-04 ! positive regulation of locomotion GO:0040017 44 22 3,000 3,825E-07 2,336E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 45 23 3,000 4,621E-07 2,258E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 5,533E-07 2,253E-04 ! regulation of behavior GO:0050795 48 25 3,000 6,573E-07 2,294E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 7,057E-07 2,155E-04 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 7,752E-07 2,104E-04 GO:0045936|negative regulation of phosphate metabolic process, ! protein amino acid autophosphorylation GO:0046777 157 64 4,000 9,633E-07 2,353E-04 ! regulation of fibroblast proliferation GO:0048145 56 28 3,000 1,057E-06 2,348E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 4,000 1,404E-06 2,859E-04 ! negative regulation of kinase activity GO:0033673 145 70 4,000 1,509E-06 2,836E-04 ! regulation of protein import into nucleus GO:0042306 69 32 3,000 1,841E-06 3,213E-04 ! negative regulation of transferase activity GO:0051348 155 74 4,000 1,991E-06 3,243E-04 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 2,000 2,405E-06 3,672E-04 ! protein oligomerization GO:0051259 149 79 4,000 2,756E-06 3,96E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 2,000 3,3E-06 4,479E-04 ! chondrocyte differentiation GO:0002062 27 11 2,000 3,3E-06 4,243E-04 ! negative regulation of glucose import GO:0046325 18 11 2,000 3,3E-06 4,031E-04 GO:0010829|negative regulation of glucose transport, ! regulation of intracellular protein transport GO:0033157 86 42 3,000 5,611E-06 6,527E-04 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 6,164E-06 6,845E-04 ! positive regulation of response to external stimulus GO:0032103 88 44 3,000 6,776E-06 7,198E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 2,000 7,236E-06 7,366E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 7,422E-06 7,253E-04 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 8,111E-06 7,622E-04 ! regulation of the force of heart contraction GO:0002026 31 15 2,000 9,027E-06 8,168E-04 ! regulation of exocytosis GO:0017157 26 15 2,000 9,027E-06 7,876E-04 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 9,027E-06 7,605E-04 ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 1,109E-05 9,03E-04 ! neutrophil chemotaxis GO:0030593 29 17 2,000 1,344E-05 1,059E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 1,609E-05 1,229E-03 ! response to UV GO:0009411 120 55 3,000 1,663E-05 1,231E-03 ! regulation of intracellular transport GO:0032386 108 57 3,000 1,918E-05 1,378E-03 ! positive regulation of cell migration GO:0030335 137 58 3,000 2,056E-05 1,435E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 2,239E-05 1,52E-03 ! regulation of glucose import GO:0046324 30 20 2,000 2,239E-05 1,479E-03 GO:0010827|regulation of glucose transport, ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 2,607E-05 1,676E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 2,607E-05 1,633E-03 ! inactivation of MAPK activity GO:0000188 45 22 2,000 3,013E-05 1,84E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 3,013E-05 1,795E-03 ! positive regulation of cell motion GO:0051272 157 65 3,000 3,233E-05 1,881E-03 ! positive regulation of cell adhesion GO:0045785 61 24 2,000 3,944E-05 2,241E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 3,944E-05 2,19E-03 ! lung development GO:0030324 165 69 3,000 4,094E-05 2,222E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 3,000 4,094E-05 2,174E-03 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 4,473E-05 2,325E-03 ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 4,473E-05 2,276E-03 ! protein tetramerization GO:0051262 57 25 2,000 4,473E-05 2,23E-03 ! respiratory tube development GO:0030323 171 72 3,000 4,841E-05 2,365E-03 ! myelination GO:0042552 50 26 2,000 5,046E-05 2,417E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 5,046E-05 2,371E-03 ! respiratory system development GO:0060541 175 74 3,000 5,391E-05 2,485E-03 ! negative regulation of protein modification process GO:0031400 66 28 2,000 6,333E-05 2,865E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 7,484E-05 3,324E-03 ! hypothalamus development GO:0021854 9 5 1,000 7,484E-05 3,265E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 7,484E-05 3,208E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 7,484E-05 3,152E-03 ! microvillus organization GO:0032528 8 5 1,000 7,484E-05 3,099E-03 GO:0030033|microvillus assembly, ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 7,484E-05 3,047E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 7,484E-05 2,997E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 7,484E-05 2,949E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 7,484E-05 2,902E-03 GO:0022011|myelination in the peripheral nervous system, ! positive regulation of phosphorylation GO:0042327 149 81 3,000 7,681E-05 2,932E-03 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 8,448E-05 3,175E-03 GO:0045937|positive regulation of phosphate metabolic process, ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 8,637E-05 3,197E-03 ! ensheathment of neurons GO:0007272 64 31 2,000 8,637E-05 3,149E-03 GO:0008366|axon ensheathment, ! negative regulation of transport GO:0051051 164 85 3,000 9,27E-05 3,33E-03 ! peripheral nervous system development GO:0007422 68 32 2,000 9,512E-05 3,368E-03 ! regulation of protein transport GO:0051223 165 87 3,000 1,015E-04 3,541E-03 GO:0070201|regulation of establishment of protein localization, ! leukocyte chemotaxis GO:0030595 55 33 2,000 1,044E-04 3,593E-03 GO:0060326|cell chemotaxis, ! forebrain regionalization GO:0021871 9 6 1,000 1,121E-04 3,802E-03 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 1,000 1,121E-04 3,75E-03 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 1,000 1,121E-04 3,699E-03 ! astrocyte development GO:0014002 16 6 1,000 1,121E-04 3,65E-03 ! Schwann cell development GO:0014044 15 6 1,000 1,121E-04 3,602E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 1,121E-04 3,555E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 1,121E-04 3,51E-03 ! ectodermal gut morphogenesis GO:0048567 16 6 1,000 1,121E-04 3,465E-03 GO:0007439|ectodermal gut development, ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 1,143E-04 3,49E-03 ! gland development GO:0048732 220 91 3,000 1,208E-04 3,644E-03 ! telencephalon development GO:0021537 81 35 2,000 1,248E-04 3,717E-03 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 1,475E-04 4,342E-03 ! regulation of protein localization GO:0032880 188 97 3,000 1,547E-04 4,498E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 1,566E-04 4,501E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,566E-04 4,448E-03 ! mRNA stabilization GO:0048255 18 7 1,000 1,566E-04 4,397E-03 GO:0043489|RNA stabilization, ! spinal cord patterning GO:0021511 14 7 1,000 1,566E-04 4,347E-03 ! male sex determination GO:0030238 15 7 1,000 1,566E-04 4,299E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 1,566E-04 4,251E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 1,566E-04 4,204E-03 ! cranial nerve morphogenesis GO:0021602 12 7 1,000 1,566E-04 4,158E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 1,566E-04 4,114E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 1,609E-04 4,182E-03 ! mammary gland development GO:0030879 93 40 2,000 1,865E-04 4,795E-03 ! regulation of action potential in neuron GO:0019228 80 40 2,000 1,865E-04 4,745E-03 ! gliogenesis GO:0042063 91 41 2,000 2,008E-04 5,057E-03 ! mesenchymal cell development GO:0014031 94 41 2,000 2,008E-04 5,005E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 2,084E-04 5,143E-03 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 2,084E-04 5,092E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 2,084E-04 5,041E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 2,084E-04 4,992E-03 ! astrocyte differentiation GO:0048708 19 8 1,000 2,084E-04 4,943E-03 ! ER overload response GO:0006983 13 8 1,000 2,084E-04 4,896E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 2,084E-04 4,849E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,084E-04 4,804E-03 ! Schwann cell differentiation GO:0014037 21 8 1,000 2,084E-04 4,759E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 2,084E-04 4,715E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 2,084E-04 4,671E-03 ! response to tumor cell GO:0002347 16 8 1,000 2,084E-04 4,629E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 2,084E-04 4,587E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 2,084E-04 4,546E-03 ! T cell differentiation GO:0030217 93 42 2,000 2,158E-04 4,665E-03 ! dorsal/ventral pattern formation GO:0009953 75 42 2,000 2,158E-04 4,624E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 2,675E-04 5,682E-03 ! cell proliferation in forebrain GO:0021846 18 9 1,000 2,675E-04 5,633E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 2,675E-04 5,585E-03 ! cerebral cortex cell migration GO:0021795 18 9 1,000 2,675E-04 5,538E-03 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 2,675E-04 5,491E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 2,831E-04 5,763E-03 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 2,831E-04 5,715E-03 ! leukocyte migration GO:0050900 75 46 2,000 2,831E-04 5,668E-03 ! positive regulation of protein transport GO:0051222 80 46 2,000 2,831E-04 5,622E-03 ! neural tube development GO:0021915 91 47 2,000 3,018E-04 5,945E-03 ! positive regulation of defense response GO:0031349 88 48 2,000 3,212E-04 6,278E-03 ! regulation of inflammatory response GO:0050727 84 48 2,000 3,212E-04 6,229E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 3,338E-04 6,42E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 3,338E-04 6,37E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 3,338E-04 6,321E-03 ! smoothened signaling pathway GO:0007224 18 10 1,000 3,338E-04 6,272E-03 ! lung alveolus development GO:0048286 26 10 1,000 3,338E-04 6,224E-03 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 3,338E-04 6,177E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 3,338E-04 6,131E-03 ! motor axon guidance GO:0008045 22 10 1,000 3,338E-04 6,085E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 3,338E-04 6,04E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 3,338E-04 5,995E-03 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 3,338E-04 5,952E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 3,338E-04 5,908E-03 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 1,000 3,338E-04 5,866E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 3,338E-04 5,824E-03 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 3,415E-04 5,917E-03 ! protein homooligomerization GO:0051260 84 49 2,000 3,415E-04 5,875E-03 ! regulation of action potential GO:0001508 102 50 2,000 3,626E-04 6,194E-03 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 3,626E-04 6,151E-03 ! negative regulation of muscle development GO:0048635 27 11 1,000 4,072E-04 6,861E-03 ! neuron fate specification GO:0048665 18 11 1,000 4,072E-04 6,814E-03 ! telencephalon cell migration GO:0022029 23 11 1,000 4,072E-04 6,767E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 4,072E-04 6,721E-03 ! blood vessel remodeling GO:0001974 30 11 1,000 4,072E-04 6,676E-03 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 4,072E-04 6,632E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 4,072E-04 6,588E-03 ! regulation of intracellular pH GO:0051453 21 11 1,000 4,072E-04 6,545E-03 ! nitric oxide metabolic process GO:0046209 17 11 1,000 4,072E-04 6,502E-03 GO:0006809|nitric oxide biosynthetic process, ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 4,072E-04 6,46E-03 ! embryonic gut development GO:0048566 19 11 1,000 4,072E-04 6,418E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 4,072E-04 6,377E-03 ! positive regulation of growth GO:0045927 96 53 2,000 4,308E-04 6,703E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 4,308E-04 6,661E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 2,000 4,308E-04 6,619E-03 ! regulation of muscle contraction GO:0006937 94 54 2,000 4,552E-04 6,95E-03 ! epithelial tube morphogenesis GO:0060562 114 54 2,000 4,552E-04 6,907E-03 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 4,878E-04 7,355E-03 ! virus-host interaction GO:0019048 30 12 1,000 4,878E-04 7,31E-03 ! regulation of B cell proliferation GO:0030888 22 12 1,000 4,878E-04 7,266E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 4,878E-04 7,222E-03 ! ventral spinal cord development GO:0021517 25 12 1,000 4,878E-04 7,178E-03 ! forebrain cell migration GO:0021885 24 12 1,000 4,878E-04 7,135E-03 ! cranial nerve development GO:0021545 23 12 1,000 4,878E-04 7,093E-03 ! histone acetylation GO:0016573 27 12 1,000 4,878E-04 7,051E-03 ! peptidyl-lysine modification GO:0018205 21 12 1,000 4,878E-04 7,009E-03 ! regulation of leukocyte migration GO:0002685 29 12 1,000 4,878E-04 6,968E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 4,878E-04 6,928E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 4,878E-04 6,888E-03 ! localization within membrane GO:0051668 26 12 1,000 4,878E-04 6,848E-03 ! regulation of DNA replication GO:0006275 105 56 2,000 5,067E-04 7,073E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 5,338E-04 7,409E-03 ! regulation of bone remodeling GO:0046850 143 57 2,000 5,338E-04 7,367E-03 ! regulation of tissue remodeling GO:0034103 146 58 2,000 5,618E-04 7,71E-03 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 5,754E-04 7,853E-03 ! response to X-ray GO:0010165 28 13 1,000 5,754E-04 7,809E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 5,754E-04 7,766E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 5,754E-04 7,724E-03 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 5,754E-04 7,681E-03 ! regulation of mRNA stability GO:0043488 32 13 1,000 5,754E-04 7,64E-03 ! digestive tract morphogenesis GO:0048546 31 13 1,000 5,754E-04 7,598E-03 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 5,754E-04 7,558E-03 ! regulation of heart contraction GO:0008016 123 61 2,000 6,513E-04 8,509E-03 ! negative regulation of response to stimulus GO:0048585 106 61 2,000 6,513E-04 8,464E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 6,701E-04 8,662E-03 GO:0060675|ureteric bud morphogenesis, ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 6,701E-04 8,616E-03 ! regulation of cellular pH GO:0030641 27 14 1,000 6,701E-04 8,571E-03 ! response to gamma radiation GO:0010332 30 14 1,000 6,701E-04 8,526E-03 ! regulation of RNA stability GO:0043487 33 14 1,000 6,701E-04 8,482E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 6,701E-04 8,438E-03 ! regulation of homeostatic process GO:0032844 148 62 2,000 6,831E-04 8,558E-03 ! regulation of mitosis GO:0007088 112 63 2,000 7,158E-04 8,922E-03 GO:0051783|regulation of nuclear division, ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 7,718E-04 9,571E-03 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 7,718E-04 9,523E-03 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 7,718E-04 9,475E-03 ! G1/S transition checkpoint GO:0031575 37 15 1,000 7,718E-04 9,428E-03 ! synaptic transmission, cholinergic GO:0007271 24 15 1,000 7,718E-04 9,381E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 8,199E-04 9,916E-03 ! negative regulation of cell growth GO:0030308 142 67 2,000 8,567E-04 0,01030948 ! activation of MAPK activity GO:0000187 124 67 2,000 8,567E-04 0,01025894 ! embryonic limb morphogenesis GO:0030326 139 67 2,000 8,567E-04 0,0102089 GO:0035113|embryonic appendage morphogenesis, ! regulation of glucose metabolic process GO:0010906 28 16 1,000 8,805E-04 0,0104417 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 8,805E-04 0,01039126 ! pituitary gland development GO:0021983 30 16 1,000 8,805E-04 0,0103413 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 8,805E-04 0,01029182 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 8,805E-04 0,01024281 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 8,805E-04 0,01019427 ! negative regulation of cell size GO:0045792 144 69 2,000 9,332E-04 0,01075393 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 9,961E-04 0,01142447 ! glial cell development GO:0021782 28 17 1,000 9,961E-04 0,01137108 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 9,961E-04 0,0113182 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 9,961E-04 0,0112658 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 1,014E-03 0,01141527 ! appendage morphogenesis GO:0035107 150 72 2,000 1,056E-03 0,01183336 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 151 73 2,000 1,099E-03 0,01225973 GO:0060173|limb development, ! limbic system development GO:0021761 40 18 1,000 1,119E-03 0,01242125 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 1,119E-03 0,01236504 ! nerve development GO:0021675 34 18 1,000 1,119E-03 0,01230934 ! regulation of caspase activity GO:0043281 136 74 2,000 1,143E-03 0,01252359 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 1,143E-03 0,01246768 ! lymphocyte differentiation GO:0030098 193 76 2,000 1,235E-03 0,01340732 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 1,248E-03 0,01348975 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 1,248E-03 0,01343032 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 1,248E-03 0,01337142 ! cerebral cortex development GO:0021987 40 19 1,000 1,248E-03 0,01331303 ! neuromuscular junction development GO:0007528 43 19 1,000 1,248E-03 0,01325515 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 1,248E-03 0,01319777 ! proximal/distal pattern formation GO:0009954 33 19 1,000 1,248E-03 0,01314088 ! embryonic organ morphogenesis GO:0048562 34 19 1,000 1,248E-03 0,01308448 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 1,282E-03 0,01338762 ! regulation of vesicle-mediated transport GO:0060627 136 77 2,000 1,282E-03 0,01333065 ! protein amino acid acetylation GO:0006473 41 20 1,000 1,384E-03 0,01432775 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 1,384E-03 0,01426729 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 1,000 1,384E-03 0,01420734 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 1,384E-03 0,0141479 ! negative regulation of T cell activation GO:0050868 41 20 1,000 1,384E-03 0,01408895 ! response to hypoxia GO:0001666 178 81 2,000 1,484E-03 0,01504121 ! diencephalon development GO:0021536 36 21 1,000 1,527E-03 0,0154156 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 1,527E-03 0,01535216 ! camera-type eye morphogenesis GO:0048593 47 21 1,000 1,527E-03 0,01528924 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 1,527E-03 0,01522683 ! regulation of peptidase activity GO:0052547 150 82 2,000 1,537E-03 0,01526468 ! protein import into nucleus GO:0006606 174 82 2,000 1,537E-03 0,01520288 ! response to oxygen levels GO:0070482 183 83 2,000 1,592E-03 0,01567818 ! nuclear import GO:0051170 177 83 2,000 1,592E-03 0,01561521 ! T cell activation GO:0042110 189 84 2,000 1,647E-03 0,01609674 ! hindlimb morphogenesis GO:0035137 47 22 1,000 1,677E-03 0,01631981 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 1,677E-03 0,01625505 ! cellular response to starvation GO:0009267 37 22 1,000 1,677E-03 0,0161908 ! ureteric bud development GO:0001657 50 22 1,000 1,677E-03 0,01612705 ! cell aging GO:0007569 48 22 1,000 1,677E-03 0,01606381 ! G1 phase GO:0051318 44 22 1,000 1,677E-03 0,01600106 ! detection of chemical stimulus GO:0009593 42 22 1,000 1,677E-03 0,0159388 ! positive regulation of B cell activation GO:0050871 42 22 1,000 1,677E-03 0,01587702 ! activation of JUN kinase activity GO:0007257 47 22 1,000 1,677E-03 0,01581572 ! gut development GO:0048565 44 22 1,000 1,677E-03 0,01575489 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 1,677E-03 0,01569453 ! negative regulation of growth GO:0045926 168 85 2,000 1,704E-03 0,01588979 ! positive regulation of DNA replication GO:0045740 44 23 1,000 1,833E-03 0,01702794 ! axis specification GO:0009798 43 23 1,000 1,833E-03 0,01696344 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 1,833E-03 0,01689942 GO:0010810|regulation of cell-substrate adhesion, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 1,833E-03 0,01683589 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 1,833E-03 0,01677284 ! regulation of DNA binding GO:0051101 167 89 2,000 1,944E-03 0,01771935 ! tube morphogenesis GO:0035239 194 89 2,000 1,944E-03 0,01765347 ! protein localization in nucleus GO:0034504 192 89 2,000 1,944E-03 0,01758809 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 1,996E-03 0,01799524 ! sex determination GO:0007530 48 24 1,000 1,996E-03 0,01792908 ! pallium development GO:0021543 56 24 1,000 1,996E-03 0,01786341 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 1,996E-03 0,01779821 ! positive regulation of protein modification process GO:0031401 156 90 2,000 2,007E-03 0,01782831 ! regulation of cell cycle process GO:0010564 161 90 2,000 2,007E-03 0,01776371 ! regulation of cell adhesion GO:0030155 241 92 2,000 2,137E-03 0,01884491 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 2,166E-03 0,01903335 ! vasculogenesis GO:0001570 49 25 1,000 2,166E-03 0,01896513 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 2,166E-03 0,01889739 ! negative regulation of DNA replication GO:0008156 45 25 1,000 2,166E-03 0,01883014 ! interaction with host GO:0051701 66 25 1,000 2,166E-03 0,01876337 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 2,204E-03 0,0190224 ! regulation of membrane potential GO:0042391 179 94 2,000 2,272E-03 0,01954147 ! regulation of defense response GO:0031347 171 95 2,000 2,341E-03 0,020068 ! protein amino acid alkylation GO:0008213 59 26 1,000 2,342E-03 0,02000677 GO:0006479|protein amino acid methylation, ! spinal cord development GO:0021510 54 26 1,000 2,342E-03 0,01993706 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 2,342E-03 0,01986783 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 2,342E-03 0,01979909 ! negative regulation of cell development GO:0010721 83 26 1,000 2,342E-03 0,01973081 GO:0050768|negative regulation of neurogenesis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 2,342E-03 0,01966301 ! neural tube closure GO:0001843 58 26 1,000 2,342E-03 0,01959567 GO:0060606|tube closure, ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 2,342E-03 0,01952879 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 2,484E-03 0,02063998 ! tube lumen formation GO:0035148 59 27 1,000 2,525E-03 0,02091057 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 2,525E-03 0,02083993 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 2,525E-03 0,02076976 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 2,525E-03 0,02070006 ! mitochondrial membrane organization GO:0007006 60 27 1,000 2,525E-03 0,02063083 ! response to starvation GO:0042594 47 27 1,000 2,525E-03 0,02056206 ! response to toxin GO:0009636 49 27 1,000 2,525E-03 0,02049375 ! cellular response to nutrient levels GO:0031669 45 27 1,000 2,525E-03 0,02042589 ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 2,525E-03 0,02035848 ! leukocyte differentiation GO:0002521 232 98 2,000 2,557E-03 0,02055055 ! forebrain development GO:0030900 210 98 2,000 2,557E-03 0,02048317 ! skeletal muscle tissue development GO:0007519 223 100 2,000 2,708E-03 0,02161942 GO:0060538|skeletal muscle organ development, ! neuron fate commitment GO:0048663 52 28 1,000 2,714E-03 0,02160009 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 2,714E-03 0,02152996 ! protein amino acid acylation GO:0043543 59 28 1,000 2,714E-03 0,02146028 ! base-excision repair GO:0006284 41 28 1,000 2,714E-03 0,02139105 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 2,714E-03 0,02132227 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 2,714E-03 0,02125393 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 2,91E-03 0,02271461 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 2,91E-03 0,02264227 ! primary neural tube formation GO:0014020 61 29 1,000 2,91E-03 0,02257039 ! somitogenesis GO:0001756 52 29 1,000 2,91E-03 0,02249896 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 3,113E-03 0,02398696 ! neurotransmitter secretion GO:0007269 55 30 1,000 3,113E-03 0,02391153 ! regulation of B cell activation GO:0050864 55 30 1,000 3,113E-03 0,02383657 ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 3,321E-03 0,02535537 ! eye morphogenesis GO:0048592 65 31 1,000 3,321E-03 0,02527638 ! metanephros development GO:0001656 81 32 1,000 3,536E-03 0,02682963 ! positive regulation of catabolic process GO:0009896 72 32 1,000 3,536E-03 0,02674657 ! regulation of pH GO:0006885 56 33 1,000 3,758E-03 0,02833348 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 3,758E-03 0,0282463 ! response to ionizing radiation GO:0010212 74 33 1,000 3,758E-03 0,02815965 ! regulation of axonogenesis GO:0050770 86 33 1,000 3,758E-03 0,02807354 ! negative regulation of protein transport GO:0051224 74 33 1,000 3,758E-03 0,02798795 ! glial cell differentiation GO:0010001 67 34 1,000 3,985E-03 0,02959377 ! cell fate specification GO:0001708 56 34 1,000 3,985E-03 0,02950409 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 3,985E-03 0,02941495 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 4,219E-03 0,03104807 ! DNA damage checkpoint GO:0000077 78 35 1,000 4,219E-03 0,03095483 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 4,219E-03 0,03086215 ! calcium-mediated signaling GO:0019722 67 35 1,000 4,219E-03 0,03077003 ! regulation of muscle development GO:0048634 82 36 1,000 4,46E-03 0,03242497 ! negative regulation of DNA binding GO:0043392 67 36 1,000 4,46E-03 0,03232875 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 4,46E-03 0,0322331 ! embryonic organ development GO:0048568 67 36 1,000 4,46E-03 0,03213802 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 4,706E-03 0,03381399 ! xenobiotic metabolic process GO:0006805 55 37 1,000 4,706E-03 0,03371482 ! odontogenesis GO:0042476 74 37 1,000 4,706E-03 0,03361624 ! tissue remodeling GO:0048771 78 37 1,000 4,706E-03 0,03351824 ! maintenance of protein location in cell GO:0032507 89 37 1,000 4,706E-03 0,0334208 ! negative regulation of cell activation GO:0050866 69 37 1,000 4,706E-03 0,03332393 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 4,959E-03 0,03501089 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 4,959E-03 0,03491 ! DNA integrity checkpoint GO:0031570 82 38 1,000 4,959E-03 0,03480968 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 4,959E-03 0,03470994 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 4,959E-03 0,03461077 ! neural tube formation GO:0001841 79 38 1,000 4,959E-03 0,03451216 ! regulation of neuron projection development GO:0010975 102 39 1,000 5,217E-03 0,03620951 ! negative regulation of binding GO:0051100 71 39 1,000 5,217E-03 0,03610693 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 5,217E-03 0,03600493 ! carbohydrate homeostasis GO:0033500 59 39 1,000 5,217E-03 0,03590351 GO:0042593|glucose homeostasis, ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 5,217E-03 0,03580266 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 5,217E-03 0,03570237 ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 5,753E-03 0,03925767 ! maintenance of protein location GO:0045185 95 41 1,000 5,753E-03 0,03914832 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 5,753E-03 0,03903957 ! regulation of T cell differentiation GO:0045580 78 42 1,000 6,03E-03 0,04080499 ! response to xenobiotic stimulus GO:0009410 63 42 1,000 6,03E-03 0,04069226 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 6,313E-03 0,04248368 GO:0090047|positive regulation of transcription regulator activity, ! regulation of T cell proliferation GO:0042129 80 43 1,000 6,313E-03 0,04236697 ! segmentation GO:0035282 78 43 1,000 6,313E-03 0,04225089 ! neuron migration GO:0001764 85 43 1,000 6,313E-03 0,04213545 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 6,313E-03 0,04202064 ! double-strand break repair GO:0006302 85 44 1,000 6,601E-03 0,04382362 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 6,896E-03 0,04565599 ! biopolymer methylation GO:0043414 91 45 1,000 6,896E-03 0,0455326 ! B cell differentiation GO:0030183 124 45 1,000 6,896E-03 0,04540987 ! developmental growth GO:0048589 88 45 1,000 6,896E-03 0,0452878 ! maintenance of location in cell GO:0051651 101 45 1,000 6,896E-03 0,04516638 ! regulation of JNK cascade GO:0046328 104 47 1,000 7,503E-03 0,04901079 ! response to insulin stimulus GO:0032868 98 47 1,000 7,503E-03 0,04888009 ! positive regulation of cell cycle GO:0045787 96 48 1,000 7,815E-03 0,05077891 ! mitochondrial transport GO:0006839 94 48 1,000 7,815E-03 0,05064422 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 7,815E-03 0,05051024 ! positive regulation of DNA binding GO:0043388 83 48 1,000 7,815E-03 0,05037697 ! vascular process in circulatory system GO:0003018 85 48 1,000 7,815E-03 0,0502444 ! methylation GO:0032259 97 48 1,000 7,815E-03 0,05011252 ! response to calcium ion GO:0051592 94 49 1,000 8,133E-03 0,05201526 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 8,133E-03 0,05187945 ! JNK cascade GO:0007254 106 49 1,000 8,133E-03 0,05174435 ! endocrine system development GO:0035270 109 50 1,000 8,457E-03 0,0536645 ! activation of caspase activity GO:0006919 95 50 1,000 8,457E-03 0,05352547 ! regulation of ossification GO:0030278 123 50 1,000 8,457E-03 0,05338716 ! regulation of cell projection organization GO:0031344 135 51 1,000 8,787E-03 0,05532421 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 8,787E-03 0,05518199 ! negative regulation of immune system process GO:0002683 101 51 1,000 8,787E-03 0,0550405 ! positive regulation of binding GO:0051099 88 52 1,000 9,122E-03 0,05699395 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 9,122E-03 0,05684856 ! histone modification GO:0016570 104 52 1,000 9,122E-03 0,0567039 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 9,122E-03 0,05655999 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 9,463E-03 0,05852474 ! synapse organization GO:0050808 102 53 1,000 9,463E-03 0,05837695 ! regulation of angiogenesis GO:0045765 125 54 1,000 9,809E-03 0,06036178 ! activation of phospholipase C activity GO:0007202 110 54 1,000 9,809E-03 0,06021011 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 1,000 9,809E-03 0,06005921 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 9,809E-03 0,05990906 ! covalent chromatin modification GO:0016569 115 54 1,000 9,809E-03 0,05975966 ! regulation of cell shape GO:0008360 142 54 1,000 9,809E-03 0,05961101 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,01016112 0,06159706 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,01016112 0,06144459 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,01051869 0,06344979 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,01088178 0,06547829 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 1,000 0,01088178 0,06531741 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,01088178 0,06515732 ! heart morphogenesis GO:0003007 105 57 1,000 0,01088178 0,06499801 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,01088178 0,06483948 ! aging GO:0007568 112 58 1,000 0,01125035 0,06687252 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,01125035 0,06671021 ! maintenance of location GO:0051235 124 58 1,000 0,01125035 0,06654869 ! regulation of neurotransmitter levels GO:0001505 113 60 1,000 0,01200382 0,07083412 ! kidney development GO:0001822 133 60 1,000 0,01200382 0,07066343 ! camera-type eye development GO:0043010 126 61 1,000 0,01238865 0,07275352 ! viral reproductive process GO:0022415 132 62 1,000 0,01277883 0,07486496 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,01277883 0,07468585 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,01317434 0,07681364 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,01357514 0,07896207 ! response to peptide hormone stimulus GO:0043434 129 64 1,000 0,01357514 0,07877451 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01371069 0,07937254 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01371069 0,0791849 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01371069 0,07899814 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01371069 0,07881226 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01371069 0,07862726 ! neuron fate determination GO:0048664 7 5 0,000 0,01371069 0,07844312 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01371069 0,07825984 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01371069 0,07807742 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01371069 0,07789584 ! polyol transport GO:0015791 12 5 0,000 0,01371069 0,07771511 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01371069 0,07753521 ! response to superoxide GO:0000303 10 5 0,000 0,01371069 0,07735615 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01371069 0,07717791 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01371069 0,07700049 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01371069 0,07682388 ! female meiosis GO:0007143 10 5 0,000 0,01371069 0,07664808 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01371069 0,07647309 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01371069 0,07629889 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01371069 0,07612548 ! cobalt ion transport GO:0006824 11 5 0,000 0,01371069 0,07595286 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01371069 0,07578102 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01371069 0,07560996 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01371069 0,07543967 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01371069 0,07527014 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01371069 0,07510137 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01371069 0,07493336 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01371069 0,0747661 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01371069 0,07459958 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01371069 0,0744338 ! transposition GO:0032196 9 5 0,000 0,01371069 0,07426876 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01371069 0,07410445 ! negative chemotaxis GO:0050919 16 5 0,000 0,01371069 0,07394086 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01371069 0,073778 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01371069 0,07361585 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01371069 0,07345441 ! behavioral response to pain GO:0048266 10 5 0,000 0,01371069 0,07329368 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01371069 0,07313365 ! Notch receptor processing GO:0007220 11 5 0,000 0,01371069 0,07297432 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01371069 0,07281568 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01371069 0,07265773 ! micturition GO:0060073 9 5 0,000 0,01371069 0,07250046 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01371069 0,07234387 ! copulation GO:0007620 9 5 0,000 0,01371069 0,07218796 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01371069 0,07203271 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01371069 0,07187814 ! bioluminescence GO:0008218 9 5 0,000 0,01371069 0,07172422 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01371069 0,07157097 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01371069 0,07141836 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01371069 0,07126641 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01371069 0,0711151 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01371069 0,07096443 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01371069 0,0708144 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01371069 0,070665 ! grooming behavior GO:0007625 6 5 0,000 0,01371069 0,07051624 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01371069 0,07036809 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01371069 0,07022057 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01371069 0,07007366 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01371069 0,06992737 ! response to protozoan GO:0001562 13 5 0,000 0,01371069 0,06978169 ! lymph vessel development GO:0001945 10 5 0,000 0,01371069 0,06963661 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01371069 0,06949214 ! endochondral ossification GO:0001958 17 5 0,000 0,01371069 0,06934826 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01371069 0,06920498 ! single strand break repair GO:0000012 8 5 0,000 0,01371069 0,06906229 ! parathyroid gland development GO:0060017 14 5 0,000 0,01371069 0,06892019 ! anagen GO:0042640 7 5 0,000 0,01371069 0,06877867 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01371069 0,06863773 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01371069 0,06849737 ! cytokine secretion GO:0050663 15 5 0,000 0,01371069 0,06835757 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01371069 0,06821835 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01371069 0,0680797 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01371069 0,06794161 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01371069 0,06780407 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01371069 0,06766709 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01371069 0,06753067 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01371069 0,06739479 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01371069 0,06725946 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01371069 0,06712467 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01371069 0,06699042 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01371069 0,06685671 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01371069 0,06672353 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01371069 0,06659088 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01371069 0,06645875 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01371069 0,06632715 ! valine metabolic process GO:0006573 12 5 0,000 0,01371069 0,06619607 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01371069 0,06606551 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01371069 0,06593546 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01371069 0,06580592 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01371069 0,06567689 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01371069 0,06554836 ! polyol catabolic process GO:0046174 9 5 0,000 0,01371069 0,06542034 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01371069 0,06529281 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01371069 0,06516578 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01371069 0,06503925 ! muscle cell migration GO:0014812 8 5 0,000 0,01371069 0,0649132 ! mitochondrial fission GO:0000266 8 5 0,000 0,01371069 0,06478764 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01371069 0,06466257 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01371069 0,06453798 ! mRNA transcription GO:0009299 10 5 0,000 0,01371069 0,06441387 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01371069 0,06429023 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01371069 0,06416707 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01371069 0,06404438 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01371069 0,06392216 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01371069 0,0638004 ! monocyte activation GO:0042117 10 5 0,000 0,01371069 0,06367911 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01371069 0,06355828 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01371069 0,0634379 ! response to food GO:0032094 6 5 0,000 0,01371069 0,06331798 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01371069 0,06319851 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01371069 0,06307949 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01371069 0,06296092 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01371069 0,0628428 ! forebrain neuron development GO:0021884 13 5 0,000 0,01371069 0,06272512 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01371069 0,06260787 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01371069 0,06249107 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01371069 0,0623747 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01371069 0,06225876 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01371069 0,06214325 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01371069 0,06202817 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01371069 0,06191352 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01371069 0,06179928 ! lipid glycosylation GO:0030259 7 5 0,000 0,01371069 0,06168547 ! nucleobase transport GO:0015851 6 5 0,000 0,01371069 0,06157208 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01371069 0,0614591 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01371069 0,06134654 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01371069 0,06123439 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01371069 0,06112265 ! basic amino acid transport GO:0015802 12 5 0,000 0,01371069 0,06101131 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01371069 0,06090038 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01371069 0,06078986 ! actin nucleation GO:0045010 11 5 0,000 0,01371069 0,06067973 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01371069 0,06057 ! depurination GO:0045007 5 5 0,000 0,01371069 0,06046067 ! depyrimidination GO:0045008 10 5 0,000 0,01371069 0,06035173 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01371069 0,06024319 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01371069 0,06013503 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01371069 0,06002726 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01371069 0,05991988 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01371069 0,05981288 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01371069 0,05970626 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01371069 0,05960002 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01371069 0,05949416 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01371069 0,05938867 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01371069 0,05928356 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01371069 0,05917882 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01371069 0,05907445 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01371069 0,05897044 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01371069 0,0588668 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01371069 0,05876353 ! response to arsenic GO:0046685 11 5 0,000 0,01371069 0,05866062 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01371069 0,05855806 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01371069 0,05845587 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01371069 0,05835403 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01371069 0,05825254 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01371069 0,05815141 ! response to mercury ion GO:0046689 8 5 0,000 0,01371069 0,05805063 ! response to cadmium ion GO:0046686 7 5 0,000 0,01371069 0,05795019 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01371069 0,05785011 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01371069 0,05775036 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01371069 0,05765097 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01371069 0,05755191 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01371069 0,05745319 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01371069 0,05735481 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01371069 0,05725677 ! decidualization GO:0046697 11 5 0,000 0,01371069 0,05715906 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01371069 0,05706169 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01371069 0,05696465 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01371069 0,05686793 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01371069 0,05677155 ! embryonic cleavage GO:0040016 6 5 0,000 0,01371069 0,05667549 ! peroxisome fission GO:0016559 5 5 0,000 0,01371069 0,05657975 ! histone demethylation GO:0016577 13 5 0,000 0,01371069 0,05648434 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01371069 0,05638925 ! mitotic recombination GO:0006312 9 5 0,000 0,01371069 0,05629447 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01371069 0,05620002 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01371069 0,05610588 ! metaphase plate congression GO:0051310 7 5 0,000 0,01371069 0,05601206 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01371069 0,05591855 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01371069 0,05582535 ! enteric nervous system development GO:0048484 8 5 0,000 0,01371069 0,05573247 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01371069 0,05563989 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01371069 0,05554761 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01371069 0,05545565 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01371069 0,05536399 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01371069 0,05527263 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01371069 0,05518157 ! B cell homeostasis GO:0001782 13 5 0,000 0,01371069 0,05509081 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01371069 0,05500035 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01371069 0,05491018 ! metaphase GO:0051323 11 5 0,000 0,01371069 0,05482031 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01371069 0,05473074 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01371069 0,05464145 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01371069 0,05455246 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01371069 0,05446376 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01371069 0,05437534 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01371069 0,05428722 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01371069 0,05419937 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01371069 0,05411181 ! response to redox state GO:0051775 6 5 0,000 0,01371069 0,05402453 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01371069 0,05393754 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01371069 0,05385082 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01371069 0,05376438 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01371069 0,05367822 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01371069 0,05359234 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01371069 0,05350673 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01371069 0,05342139 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01371069 0,05333632 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01371069 0,05325153 ! striatum development GO:0021756 14 5 0,000 0,01371069 0,053167 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01371069 0,05308274 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01371069 0,05299875 ! glial cell migration GO:0008347 10 5 0,000 0,01371069 0,05291503 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01371069 0,05283156 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01371069 0,05274836 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01371069 0,05266543 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01371069 0,05258275 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01371069 0,05250033 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01371069 0,05241817 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01371069 0,05233627 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01371069 0,05225462 ! neuroprotection GO:0043526 8 5 0,000 0,01371069 0,05217323 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01371069 0,05209209 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01371069 0,0520112 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01371069 0,05193056 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01371069 0,05185017 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01371069 0,05177003 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01371069 0,05169014 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01371069 0,0516105 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01371069 0,05153109 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01371069 0,05145194 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01371069 0,05137302 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01371069 0,05129435 ! spindle assembly GO:0051225 6 5 0,000 0,01371069 0,05121592 ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01371069 0,05113773 ! protein palmitoylation GO:0018345 12 5 0,000 0,01371069 0,05105977 ! drug metabolic process GO:0017144 7 5 0,000 0,01371069 0,05098206 ! stem cell division GO:0017145 11 5 0,000 0,01371069 0,05090458 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01371069 0,05082733 ! organ regeneration GO:0031100 7 5 0,000 0,01371069 0,05075032 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01371069 0,05067354 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01371069 0,050597 ! regulation of lipid metabolic process GO:0019216 132 66 1,000 0,01439249 0,05303297 ! chromosome segregation GO:0007059 127 67 1,000 0,01480898 0,05448544 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,01523063 0,05595253 ! viral reproduction GO:0016032 142 68 1,000 0,01523063 0,05586852 ! regulation of lipase activity GO:0060191 137 68 1,000 0,01523063 0,05578476 ! adaptive immune response GO:0002250 126 68 1,000 0,01523063 0,05570125 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 1,000 0,01523063 0,05561799 ! urogenital system development GO:0001655 149 69 1,000 0,01565742 0,05709116 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01643041 0,05982042 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01643041 0,0597314 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01643041 0,05964265 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01643041 0,05955416 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01643041 0,05946593 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01643041 0,05937796 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01643041 0,05929026 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01643041 0,05920281 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01643041 0,05911562 ! response to oxygen radical GO:0000305 11 6 0,000 0,01643041 0,05902868 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01643041 0,058942 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01643041 0,05885558 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01643041 0,0587694 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01643041 0,05868348 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01643041 0,05859781 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01643041 0,0585124 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01643041 0,05842722 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01643041 0,0583423 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01643041 0,05825762 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01643041 0,05817319 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01643041 0,05808901 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01643041 0,05800506 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01643041 0,05792136 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01643041 0,0578379 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01643041 0,05775468 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01643041 0,0576717 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01643041 0,05758896 ! malate metabolic process GO:0006108 13 6 0,000 0,01643041 0,05750645 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01643041 0,05742418 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01643041 0,05734215 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01643041 0,05726035 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01643041 0,05717878 ! protein refolding GO:0042026 15 6 0,000 0,01643041 0,05709744 ! opsonization GO:0008228 8 6 0,000 0,01643041 0,05701634 ! mating behavior GO:0007617 7 6 0,000 0,01643041 0,05693547 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01643041 0,05685482 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01643041 0,0567744 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01643041 0,05669421 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01643041 0,05661425 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01643041 0,05653451 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01643041 0,056455 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01643041 0,05637571 ! toxin metabolic process GO:0009404 11 6 0,000 0,01643041 0,05629664 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01643041 0,05621779 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01643041 0,05613917 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01643041 0,05606076 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01643041 0,05598257 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01643041 0,0559046 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01643041 0,05582685 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01643041 0,05574931 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01643041 0,05567199 ! thymic T cell selection GO:0045061 16 6 0,000 0,01643041 0,05559488 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01643041 0,05551798 ! protein lipoylation GO:0009249 10 6 0,000 0,01643041 0,0554413 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01643041 0,05536483 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01643041 0,05528857 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01643041 0,05521252 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01643041 0,05513668 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01643041 0,05506105 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01643041 0,05498562 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01643041 0,0549104 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01643041 0,05483539 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01643041 0,05476058 ! hyperosmotic response GO:0006972 10 6 0,000 0,01643041 0,05468597 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01643041 0,05461157 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01643041 0,05453737 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01643041 0,05446337 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01643041 0,05438957 ! urea metabolic process GO:0019627 7 6 0,000 0,01643041 0,05431597 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01643041 0,05424257 ! neutrophil activation GO:0042119 7 6 0,000 0,01643041 0,05416937 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01643041 0,05409637 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01643041 0,05402356 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01643041 0,05395094 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01643041 0,05387853 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01643041 0,0538063 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01643041 0,05373427 ! neuron apoptosis GO:0051402 15 6 0,000 0,01643041 0,05366244 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01643041 0,05359079 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01643041 0,05351934 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01643041 0,05344807 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01643041 0,053377 ! carnitine transport GO:0015879 10 6 0,000 0,01643041 0,05330611 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01643041 0,05323542 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01643041 0,0531649 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01643041 0,05309458 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01643041 0,05302444 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01643041 0,05295449 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01643041 0,05288472 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01643041 0,05281514 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01643041 0,05274573 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01643041 0,05267651 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01643041 0,05260747 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01643041 0,05253862 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01643041 0,05246994 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01643041 0,05240144 ! response to UV-C GO:0010225 14 6 0,000 0,01643041 0,05233312 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01643041 0,05226498 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01643041 0,05219701 ! interaction with symbiont GO:0051702 14 6 0,000 0,01643041 0,05212922 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01643041 0,05206161 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01643041 0,05199417 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01643041 0,05192691 ! response to copper ion GO:0046688 10 6 0,000 0,01643041 0,05185982 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01643041 0,05179291 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01643041 0,05172616 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01643041 0,05165959 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01643041 0,05159319 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01643041 0,05152696 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01643041 0,0514609 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01643041 0,05139501 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01643041 0,05132929 ! hair follicle maturation GO:0048820 8 6 0,000 0,01643041 0,05126373 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01643041 0,05119835 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01643041 0,05113312 ! response to pheromone GO:0019236 6 6 0,000 0,01643041 0,05106807 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01643041 0,05100318 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01643041 0,05093846 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01643041 0,05087389 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01643041 0,0508095 ! subpallium development GO:0021544 15 6 0,000 0,01643041 0,05074526 ! neural tube patterning GO:0021532 8 6 0,000 0,01643041 0,05068119 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01643041 0,05061728 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01643041 0,05055353 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01643041 0,05048994 ! G2 phase GO:0051319 16 6 0,000 0,01643041 0,05042651 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01643041 0,05036324 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01643041 0,05030013 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01643041 0,05023718 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01643041 0,05017438 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01643041 0,05011174 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01643041 0,05004926 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01643041 0,04998693 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01643041 0,04992475 ! receptor internalization GO:0031623 11 6 0,000 0,01643041 0,04986274 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01643041 0,04980087 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01643041 0,04973916 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01643041 0,0496776 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01643041 0,0496162 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01643041 0,04955494 ! protein deubiquitination GO:0016579 16 6 0,000 0,01643041 0,04949384 ! protein destabilization GO:0031648 9 6 0,000 0,01643041 0,04943289 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01643041 0,04937208 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01643041 0,04931143 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01643041 0,04925092 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01643041 0,04919057 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01643041 0,04913036 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01643041 0,0490703 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01643041 0,04901038 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01643041 0,04895061 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01643041 0,04889099 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01643041 0,04883151 ! neural plate development GO:0001840 9 6 0,000 0,01643041 0,04877218 ! catecholamine transport GO:0051937 9 6 0,000 0,01643041 0,04871299 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01643041 0,04865394 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01643041 0,04859504 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01643041 0,04853628 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01643041 0,04847766 ! maternal placenta development GO:0001893 12 6 0,000 0,01643041 0,04841918 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01643041 0,04836085 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01643041 0,04830265 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01643041 0,04824459 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01643041 0,04818668 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01643041 0,0481289 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01643041 0,04807126 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01643041 0,04801376 GO:0055081|anion homeostasis, ! cell cycle checkpoint GO:0000075 145 71 1,000 0,01652628 0,0482362 ! B cell activation GO:0042113 179 72 1,000 0,01696829 0,04946722 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,01696829 0,04940826 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,01832427 0,05329309 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,01832427 0,05322972 ! eye development GO:0001654 155 75 1,000 0,01832427 0,0531665 ! axon guidance GO:0007411 162 75 1,000 0,01832427 0,05310344 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,01878615 0,05437744 ! learning or memory GO:0007611 161 76 1,000 0,01878615 0,05431309 ! tRNA transcription GO:0009304 17 7 0,000 0,01914272 0,05527856 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01914272 0,05521329 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01914272 0,05514818 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01914272 0,05508323 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,01914272 0,05501842 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01914272 0,05495377 ! sleep GO:0030431 16 7 0,000 0,01914272 0,05488927 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01914272 0,05482492 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01914272 0,05476072 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01914272 0,05469668 ! prostate gland development GO:0030850 14 7 0,000 0,01914272 0,05463278 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01914272 0,05456903 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01914272 0,05450543 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01914272 0,05444198 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01914272 0,05437867 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01914272 0,05431552 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01914272 0,0542525 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01914272 0,05418964 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01914272 0,05412692 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01914272 0,05406435 ! glycolipid transport GO:0046836 11 7 0,000 0,01914272 0,05400192 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01914272 0,05393963 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,01914272 0,05387749 ! neuron adhesion GO:0007158 14 7 0,000 0,01914272 0,05381549 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,01914272 0,05375363 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01914272 0,05369192 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01914272 0,05363034 ! pericardium development GO:0060039 16 7 0,000 0,01914272 0,05356891 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01914272 0,05350762 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01914272 0,05344647 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01914272 0,05338546 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01914272 0,05332458 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01914272 0,05326385 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01914272 0,05320325 ! lipoprotein transport GO:0042953 14 7 0,000 0,01914272 0,05314279 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01914272 0,05308247 ! rhythmic behavior GO:0007622 17 7 0,000 0,01914272 0,05302229 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01914272 0,05296224 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01914272 0,05290233 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01914272 0,05284255 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01914272 0,05278291 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01914272 0,0527234 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01914272 0,05266403 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01914272 0,05260479 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01914272 0,05254568 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01914272 0,05248671 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01914272 0,05242787 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01914272 0,05236916 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01914272 0,05231058 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01914272 0,05225213 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01914272 0,05219382 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01914272 0,05213563 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01914272 0,05207757 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01914272 0,05201964 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01914272 0,05196184 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01914272 0,05190417 ! adrenal gland development GO:0030325 17 7 0,000 0,01914272 0,05184663 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01914272 0,05178921 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01914272 0,05173192 ! ovulation GO:0030728 10 7 0,000 0,01914272 0,05167476 ! adenohypophysis development GO:0021984 11 7 0,000 0,01914272 0,05161773 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01914272 0,05156081 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01914272 0,05150403 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01914272 0,05144737 ! microtubule nucleation GO:0007020 21 7 0,000 0,01914272 0,05139083 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01914272 0,05133442 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01914272 0,05127813 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01914272 0,05122197 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01914272 0,05116593 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01914272 0,05111001 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01914272 0,05105421 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01914272 0,05099854 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01914272 0,05094298 ! galactose metabolic process GO:0006012 13 7 0,000 0,01914272 0,05088755 ! vesicle fusion GO:0006906 20 7 0,000 0,01914272 0,05083224 ! response to dietary excess GO:0002021 8 7 0,000 0,01914272 0,05077705 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01914272 0,05072197 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01914272 0,05066702 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01914272 0,05061218 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01914272 0,05055747 ! organ growth GO:0035265 15 7 0,000 0,01914272 0,05050287 ! nucleoside transport GO:0015858 11 7 0,000 0,01914272 0,05044839 ! nucleoside salvage GO:0043174 11 7 0,000 0,01914272 0,05039403 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01914272 0,05033978 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01914272 0,05028565 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01914272 0,05023164 ! parturition GO:0007567 16 7 0,000 0,01914272 0,05017775 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,01914272 0,05012396 ! rRNA modification GO:0000154 14 7 0,000 0,01914272 0,0500703 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01914272 0,05001675 ! spindle checkpoint GO:0031577 16 7 0,000 0,01914272 0,04996331 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01914272 0,04990999 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01914272 0,04985678 ! monocyte differentiation GO:0030224 16 7 0,000 0,01914272 0,04980368 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01914272 0,0497507 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01914272 0,04969783 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,01914272 0,04964507 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01914272 0,04959243 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01914272 0,04953989 ! fibrinolysis GO:0042730 11 7 0,000 0,01914272 0,04948747 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01914272 0,04943516 ! eating behavior GO:0042755 8 7 0,000 0,01914272 0,04938296 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01914272 0,04933086 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01914272 0,04927888 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01914272 0,04922701 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01914272 0,04917525 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,01914272 0,04912359 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01914272 0,04907205 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01914272 0,04902061 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01914272 0,04896928 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01914272 0,04891805 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01914272 0,04886694 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01914272 0,04881593 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01914272 0,04876502 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01914272 0,04871423 ! histone ubiquitination GO:0016574 9 7 0,000 0,01914272 0,04866354 ! regulation of meiosis GO:0040020 12 7 0,000 0,01914272 0,04861295 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01914272 0,04856247 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01914272 0,04851209 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01914272 0,04846182 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01914272 0,04841166 ! transcription termination GO:0006353 14 7 0,000 0,01914272 0,04836159 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01914272 0,04831163 ! anaphase GO:0051322 18 7 0,000 0,01914272 0,04826177 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01914272 0,04821202 ! axonal fasciculation GO:0007413 19 7 0,000 0,01914272 0,04816237 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01914272 0,04811282 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01914272 0,04806337 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01914272 0,04801402 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01914272 0,04796478 ! diuresis GO:0030146 12 7 0,000 0,01914272 0,04791563 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01914272 0,04786659 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01914272 0,04781765 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01914272 0,0477688 ! antibiotic transport GO:0042891 9 7 0,000 0,01914272 0,04772006 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01914272 0,04767142 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01914272 0,04762287 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01914272 0,04757442 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01914272 0,04752608 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01914272 0,04747783 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01914272 0,04742967 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01914272 0,04738162 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01914272 0,04733366 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01914272 0,0472858 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01914272 0,04723804 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01914272 0,04719037 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01914272 0,0471428 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01914272 0,04709533 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01914272 0,04704795 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01914272 0,04700066 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01914272 0,04695347 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01914272 0,04690638 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01914272 0,04685938 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01914272 0,04681247 ! muscle adaptation GO:0043500 13 7 0,000 0,01914272 0,04676566 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01914272 0,04671894 ! retina homeostasis GO:0001895 12 7 0,000 0,01914272 0,04667231 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01914272 0,04662578 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01914272 0,04657934 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,01914272 0,04653299 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01914272 0,04648674 ! neurotransmitter transport GO:0006836 142 77 1,000 0,01925292 0,04670792 ! regulation of catabolic process GO:0009894 173 77 1,000 0,01925292 0,04666159 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,01972455 0,04775726 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,02165909 0,05238927 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02184762 0,05279301 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02184762 0,05274084 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02184762 0,05268877 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02184762 0,05263681 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02184762 0,05258495 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02184762 0,0525332 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02184762 0,05248154 ! male meiosis GO:0007140 9 8 0,000 0,02184762 0,05242999 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02184762 0,05237854 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02184762 0,05232718 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02184762 0,05227593 ! meiotic prophase I GO:0007128 14 8 0,000 0,02184762 0,05222478 ! response to zinc ion GO:0010043 12 8 0,000 0,02184762 0,05217373 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02184762 0,05212278 ! oligopeptide transport GO:0006857 16 8 0,000 0,02184762 0,05207193 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02184762 0,05202118 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02184762 0,05197052 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02184762 0,05191997 ! signal peptide processing GO:0006465 12 8 0,000 0,02184762 0,05186951 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02184762 0,05181915 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02184762 0,05176889 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02184762 0,05171873 ! succinate metabolic process GO:0006105 17 8 0,000 0,02184762 0,05166866 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02184762 0,05161869 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02184762 0,05156882 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02184762 0,05151904 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02184762 0,05146936 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02184762 0,05141978 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02184762 0,05137029 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02184762 0,05132089 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02184762 0,05127159 ! reflex GO:0060004 17 8 0,000 0,02184762 0,05122239 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02184762 0,05117328 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02184762 0,05112426 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02184762 0,05107534 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02184762 0,05102651 ! pigment granule organization GO:0048753 17 8 0,000 0,02184762 0,05097777 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02184762 0,05092913 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02184762 0,05088058 ! histidine catabolic process GO:0006548 10 8 0,000 0,02184762 0,05083212 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02184762 0,05078376 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02184762 0,05073548 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02184762 0,0506873 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02184762 0,05063921 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02184762 0,05059121 ! melanin metabolic process GO:0006582 17 8 0,000 0,02184762 0,0505433 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02184762 0,05049549 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02184762 0,05044776 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02184762 0,05040012 ! macrophage activation GO:0042116 13 8 0,000 0,02184762 0,05035257 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02184762 0,05030512 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02184762 0,05025775 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02184762 0,05021047 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02184762 0,05016328 ! purine salvage GO:0043101 12 8 0,000 0,02184762 0,05011618 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02184762 0,05006916 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02184762 0,05002224 ! osteoblast development GO:0002076 17 8 0,000 0,02184762 0,0499754 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02184762 0,04992865 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02184762 0,04988199 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02184762 0,04983541 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02184762 0,04978893 ! response to UV-B GO:0010224 17 8 0,000 0,02184762 0,04974252 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02184762 0,04969621 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02184762 0,04964998 ! intermediate filament organization GO:0045109 12 8 0,000 0,02184762 0,04960384 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02184762 0,04955778 ! cellular extravasation GO:0045123 13 8 0,000 0,02184762 0,04951181 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02184762 0,04946592 ! response to antibiotic GO:0046677 11 8 0,000 0,02184762 0,04942012 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02184762 0,0493744 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02184762 0,04932877 ! DNA topological change GO:0006265 12 8 0,000 0,02184762 0,04928322 ! response to tropane GO:0014073 15 8 0,000 0,02184762 0,04923776 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,02184762 0,04919238 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02184762 0,04914708 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02184762 0,04910187 ! mast cell activation GO:0045576 14 8 0,000 0,02184762 0,04905674 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02184762 0,04901169 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02184762 0,04896672 ! gas homeostasis GO:0033483 14 8 0,000 0,02184762 0,04892184 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02184762 0,04887704 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02184762 0,04883232 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02184762 0,04878769 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02184762 0,04874313 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02184762 0,04869866 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,02184762 0,04865426 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02184762 0,04860995 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02184762 0,04856572 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02184762 0,04852157 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02184762 0,0484775 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02184762 0,04843351 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02184762 0,0483896 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02184762 0,04834577 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02184762 0,04830202 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02184762 0,04825834 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02184762 0,04821475 ! hormone catabolic process GO:0042447 17 8 0,000 0,02184762 0,04817124 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02184762 0,0481278 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02184762 0,04808444 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02184762 0,04804116 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02184762 0,04799796 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02184762 0,04795483 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02184762 0,04791178 ! adult feeding behavior GO:0008343 10 8 0,000 0,02184762 0,04786881 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02184762 0,04782592 ! ATP catabolic process GO:0006200 11 8 0,000 0,02184762 0,04778311 ! blastocyst growth GO:0001832 19 8 0,000 0,02184762 0,04774037 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02184762 0,0476977 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02184762 0,04765511 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02184762 0,0476126 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02184762 0,04757017 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02184762 0,04752781 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02184762 0,04748552 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02184762 0,04744331 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02184762 0,04740118 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02184762 0,04735912 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02184762 0,04731714 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02184762 0,04727522 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02184762 0,04723339 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02184762 0,04719163 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02184762 0,04714994 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02184762 0,04710832 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02184762 0,04706678 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02184762 0,04702531 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02184762 0,04698392 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02184762 0,04694259 ! response to drug GO:0042493 149 83 1,000 0,02215459 0,04756033 ! response to metal ion GO:0010038 158 84 1,000 0,02265477 0,04859139 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,0231596 0,04963062 ! cellular response to hormone stimulus GO:0032870 182 85 1,000 0,0231596 0,04958712 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,02366906 0,05063356 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 1,000 0,02418313 0,05168799 ! axon extension GO:0048675 16 9 0,000 0,02454513 0,05241587 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02454513 0,0523701 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02454513 0,0523244 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02454513 0,05227878 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02454513 0,05223324 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02454513 0,05218778 ! reproductive behavior GO:0019098 22 9 0,000 0,02454513 0,0521424 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02454513 0,0520971 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02454513 0,05205188 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02454513 0,05200673 ! UTP metabolic process GO:0046051 10 9 0,000 0,02454513 0,05196166 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02454513 0,05191668 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02454513 0,05187176 ! artery development GO:0060840 25 9 0,000 0,02454513 0,05182693 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02454513 0,05178218 ! equilibrioception GO:0050957 20 9 0,000 0,02454513 0,0517375 ! chemosensory behavior GO:0007635 21 9 0,000 0,02454513 0,0516929 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02454513 0,05164837 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02454513 0,05160392 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02454513 0,05155955 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02454513 0,05151526 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02454513 0,05147104 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02454513 0,0514269 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02454513 0,05138283 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02454513 0,05133884 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02454513 0,05129492 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02454513 0,05125108 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02454513 0,05120731 ! protein targeting to ER GO:0045047 25 9 0,000 0,02454513 0,05116362 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02454513 0,05112 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02454513 0,05107646 ! T cell selection GO:0045058 27 9 0,000 0,02454513 0,05103299 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 0,000 0,02454513 0,05098959 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02454513 0,05094627 ! glycine catabolic process GO:0006546 15 9 0,000 0,02454513 0,05090302 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02454513 0,05085985 ! endosome organization GO:0007032 20 9 0,000 0,02454513 0,05081675 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02454513 0,05077372 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02454513 0,05073076 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02454513 0,05068788 ! mannose metabolic process GO:0006013 13 9 0,000 0,02454513 0,05064507 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02454513 0,05060233 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02454513 0,05055966 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02454513 0,05051707 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02454513 0,05047455 ! receptor clustering GO:0043113 20 9 0,000 0,02454513 0,05043209 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02454513 0,05038971 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02454513 0,05034741 ! retinol metabolic process GO:0042572 20 9 0,000 0,02454513 0,05030517 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02454513 0,050263 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02454513 0,0502209 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02454513 0,05017888 ! macrophage differentiation GO:0030225 15 9 0,000 0,02454513 0,05013692 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02454513 0,05009504 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02454513 0,05005322 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02454513 0,05001148 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02454513 0,0499698 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02454513 0,04992819 ! response to amine stimulus GO:0014075 13 9 0,000 0,02454513 0,04988666 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02454513 0,04984519 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02454513 0,04980379 ! erythrocyte development GO:0048821 17 9 0,000 0,02454513 0,04976246 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02454513 0,04972119 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02454513 0,04968 ! renal water homeostasis GO:0003091 15 9 0,000 0,02454513 0,04963887 ! postreplication repair GO:0006301 25 9 0,000 0,02454513 0,04959782 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02454513 0,04955683 ! icosanoid secretion GO:0032309 15 9 0,000 0,02454513 0,0495159 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02454513 0,04947505 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02454513 0,04943426 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02454513 0,04939354 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02454513 0,04935289 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02454513 0,0493123 ! sterol catabolic process GO:0016127 14 9 0,000 0,02454513 0,04927178 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02454513 0,04923133 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02454513 0,04919094 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02454513 0,04915062 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02454513 0,04911037 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,02454513 0,04907018 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02454513 0,04903006 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02454513 0,04899 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02454513 0,04895001 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02454513 0,04891008 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02454513 0,04887022 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02454513 0,04883042 ! purine base metabolic process GO:0006144 25 9 0,000 0,02454513 0,04879069 ! pigment granule transport GO:0051904 17 9 0,000 0,02454513 0,04875102 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02454513 0,04871142 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02454513 0,04867188 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02454513 0,04863241 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02454513 0,048593 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02454513 0,04855365 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02454513 0,04851437 ! mitochondrion localization GO:0051646 18 9 0,000 0,02454513 0,04847515 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,02470175 0,04874506 ! response to inorganic substance GO:0010035 173 90 1,000 0,02575261 0,05077774 ! ossification GO:0001503 205 91 1,000 0,02628478 0,05178525 ! bone development GO:0060348 206 92 1,000 0,0268214 0,0527999 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02723529 0,0535715 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02723529 0,0535284 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02723529 0,05348537 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02723529 0,05344241 ! associative learning GO:0008306 21 10 0,000 0,02723529 0,05339952 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02723529 0,0533567 ! phosphate transport GO:0006817 24 10 0,000 0,02723529 0,05331395 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02723529 0,05327126 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02723529 0,05322864 ! CTP metabolic process GO:0046036 11 10 0,000 0,02723529 0,05318609 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02723529 0,05314361 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02723529 0,0531012 ! GTP metabolic process GO:0046039 11 10 0,000 0,02723529 0,05305885 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02723529 0,05301658 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02723529 0,05297437 ! social behavior GO:0035176 29 10 0,000 0,02723529 0,05293222 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02723529 0,05289015 GO:0048200|Golgi transport vesicle coating, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02723529 0,05284814 ! androgen metabolic process GO:0008209 17 10 0,000 0,02723529 0,05280619 ! phospholipid efflux GO:0033700 19 10 0,000 0,02723529 0,05276432 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02723529 0,05272251 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02723529 0,05268076 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02723529 0,05263908 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02723529 0,05259747 ! pathogenesis GO:0009405 17 10 0,000 0,02723529 0,05255593 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02723529 0,05251445 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02723529 0,05247303 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02723529 0,05243168 ! endoderm development GO:0007492 18 10 0,000 0,02723529 0,0523904 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02723529 0,05234918 ! arginine catabolic process GO:0006527 17 10 0,000 0,02723529 0,05230802 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02723529 0,05226693 ! proline metabolic process GO:0006560 13 10 0,000 0,02723529 0,05222591 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02723529 0,05218494 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02723529 0,05214405 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02723529 0,05210321 ! V(D)J recombination GO:0033151 34 10 0,000 0,02723529 0,05206244 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02723529 0,05202174 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02723529 0,0519811 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02723529 0,05194052 ! B cell proliferation GO:0042100 19 10 0,000 0,02723529 0,0519 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02723529 0,05185955 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02723529 0,05181916 ! multicellular organism growth GO:0035264 19 10 0,000 0,02723529 0,05177884 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02723529 0,05173857 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02723529 0,05169837 ! ruffle organization GO:0031529 17 10 0,000 0,02723529 0,05165823 ! epithelial cell development GO:0002064 21 10 0,000 0,02723529 0,05161816 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02723529 0,05157814 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02723529 0,05153819 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02723529 0,0514983 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02723529 0,05145847 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02723529 0,0514187 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02723529 0,051379 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,02723529 0,05133935 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02723529 0,05129977 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02723529 0,05126025 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02723529 0,05122079 ! segment specification GO:0007379 15 10 0,000 0,02723529 0,05118139 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02723529 0,05114205 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02723529 0,05110277 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02723529 0,05106355 ! response to dsRNA GO:0043331 23 10 0,000 0,02723529 0,05102439 ! DNA ligation GO:0006266 18 10 0,000 0,02723529 0,05098529 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02723529 0,05094625 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02723529 0,05090727 ! melanosome localization GO:0032400 16 10 0,000 0,02723529 0,05086835 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02723529 0,05082949 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02723529 0,05079069 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02723529 0,05075195 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02723529 0,05071326 ! induction of an organ GO:0001759 17 10 0,000 0,02723529 0,05067464 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02723529 0,05063608 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02723529 0,05059757 ! protein sumoylation GO:0016925 17 10 0,000 0,02723529 0,05055912 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02723529 0,05052073 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02723529 0,0504824 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02723529 0,05044413 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02723529 0,05040591 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02723529 0,05036775 ! salivary gland development GO:0007431 28 10 0,000 0,02723529 0,05032965 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02723529 0,05029161 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02723529 0,05025363 ! midbrain development GO:0030901 14 10 0,000 0,02723529 0,0502157 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02723529 0,05017783 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02723529 0,05014002 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02723529 0,05010226 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02723529 0,05006456 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02723529 0,05002692 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02723529 0,04998933 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02723529 0,0499518 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02723529 0,04991433 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02723529 0,04987691 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02723529 0,04983955 ! blastocyst formation GO:0001825 18 10 0,000 0,02723529 0,04980225 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02723529 0,049765 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02723529 0,04972781 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02723529 0,04969067 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02723529 0,04965358 ! response to nicotine GO:0035094 20 10 0,000 0,02723529 0,04961656 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02723529 0,04957959 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,02845772 0,05176636 ! regulation of T cell activation GO:0050863 175 96 1,000 0,02901189 0,05273516 ! respiratory burst GO:0045730 17 11 0,000 0,0299181 0,05434194 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,0299181 0,05430156 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,0299181 0,05426125 ! thyroid gland development GO:0030878 26 11 0,000 0,0299181 0,054221 ! synapsis GO:0007129 14 11 0,000 0,0299181 0,05418081 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,0299181 0,05414067 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,0299181 0,0541006 ! response to pain GO:0048265 27 11 0,000 0,0299181 0,05406058 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,0299181 0,05402063 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,0299181 0,05398073 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,0299181 0,05394089 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,0299181 0,05390111 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,0299181 0,05386139 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,0299181 0,05382173 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,0299181 0,05378212 ! melanocyte differentiation GO:0030318 20 11 0,000 0,0299181 0,05374258 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,0299181 0,05370309 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,0299181 0,05366366 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,0299181 0,05362429 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,0299181 0,05358498 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,0299181 0,05354572 ! UV protection GO:0009650 20 11 0,000 0,0299181 0,05350652 ! adult heart development GO:0007512 16 11 0,000 0,0299181 0,05346738 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,0299181 0,05342829 ! macroautophagy GO:0016236 19 11 0,000 0,0299181 0,05338927 ! temperature homeostasis GO:0001659 18 11 0,000 0,0299181 0,0533503 ! behavioral fear response GO:0001662 27 11 0,000 0,0299181 0,05331138 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,0299181 0,05327253 ! negative regulation of ossification GO:0030279 27 11 0,000 0,0299181 0,05323373 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,0299181 0,05319498 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,0299181 0,0531563 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,0299181 0,05311766 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,0299181 0,05307909 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,0299181 0,05304057 ! regulation of organ growth GO:0046620 14 11 0,000 0,0299181 0,05300211 ! pigment granule localization GO:0051875 20 11 0,000 0,0299181 0,0529637 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,0299181 0,05292535 ! vasoconstriction GO:0042310 20 11 0,000 0,0299181 0,05288705 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,0299181 0,05284881 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,0299181 0,05281063 ! embryonic axis specification GO:0000578 19 11 0,000 0,0299181 0,0527725 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,0299181 0,05273442 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,0299181 0,0526964 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,0299181 0,05265843 ! DNA methylation GO:0006306 19 11 0,000 0,0299181 0,05262052 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,0299181 0,05258267 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,0299181 0,05254486 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,0299181 0,05250712 ! prophase GO:0051324 17 11 0,000 0,0299181 0,05246942 ! neuroblast proliferation GO:0007405 25 11 0,000 0,0299181 0,05243178 ! nucleosome positioning GO:0016584 15 11 0,000 0,0299181 0,0523942 ! regulation of isotype switching GO:0045191 24 11 0,000 0,0299181 0,05235667 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,0299181 0,05231919 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,0299181 0,05228176 ! apical protein localization GO:0045176 18 11 0,000 0,0299181 0,05224439 ! acid secretion GO:0046717 20 11 0,000 0,0299181 0,05220708 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,0299181 0,05216981 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,0299181 0,0521326 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,0299181 0,05209544 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,0299181 0,05205834 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,0299181 0,05202129 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,0299181 0,05198429 ! cholesterol efflux GO:0033344 21 11 0,000 0,0299181 0,05194734 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,0299181 0,05191044 ! oocyte development GO:0048599 20 11 0,000 0,0299181 0,0518736 ! germ cell migration GO:0008354 26 11 0,000 0,0299181 0,05183681 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,0299181 0,05180008 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,0299181 0,05176339 ! activation of innate immune response GO:0002218 16 11 0,000 0,0299181 0,05172676 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,0299181 0,05169017 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,0299181 0,05165364 ! lysogeny GO:0030069 22 11 0,000 0,0299181 0,05161717 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,0299181 0,05158074 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,0299181 0,05154436 ! sequestering of metal ion GO:0051238 15 11 0,000 0,0299181 0,05150804 ! nucleus localization GO:0051647 22 11 0,000 0,0299181 0,05147176 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,03259358 0,05603527 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,03259358 0,05599586 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,03259358 0,05595651 ! mating GO:0007618 17 12 0,000 0,03259358 0,05591722 ! protein complex disassembly GO:0043241 28 12 0,000 0,03259358 0,05587798 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,03259358 0,05583879 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,03259358 0,05579966 ! hippocampus development GO:0021766 29 12 0,000 0,03259358 0,05576059 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,03259358 0,05572157 ! T cell proliferation GO:0042098 32 12 0,000 0,03259358 0,0556826 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03259358 0,05564369 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,03259358 0,05560483 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,03259358 0,05556603 ! drug transport GO:0015893 16 12 0,000 0,03259358 0,05552728 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,03259358 0,05548858 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,03259358 0,05544994 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,03259358 0,05541136 ! polyamine metabolic process GO:0006595 18 12 0,000 0,03259358 0,05537282 ! focal adhesion formation GO:0048041 37 12 0,000 0,03259358 0,05533434 ! mitotic spindle organization GO:0007052 23 12 0,000 0,03259358 0,05529591 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,03259358 0,05525754 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,03259358 0,05521922 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 21 12 0,000 0,03259358 0,05518095 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,03259358 0,05514274 ! entry into host cell GO:0030260 34 12 0,000 0,03259358 0,05510458 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03259358 0,05506647 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,03259358 0,05502842 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,03259358 0,05499041 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03259358 0,05495246 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,03259358 0,05491456 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,03259358 0,05487672 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,03259358 0,05483892 ! snRNA metabolic process GO:0016073 30 12 0,000 0,03259358 0,05480118 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,03259358 0,05476349 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,03259358 0,05472585 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03259358 0,05468827 ! fucose catabolic process GO:0019317 25 12 0,000 0,03259358 0,05465073 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,03259358 0,05461325 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,03259358 0,05457582 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03259358 0,05453844 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,03259358 0,05450111 ! zymogen activation GO:0031638 18 12 0,000 0,03259358 0,05446383 ! T cell homeostasis GO:0043029 28 12 0,000 0,03259358 0,0544266 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,03259358 0,05438942 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,03259358 0,0543523 ! oocyte differentiation GO:0009994 21 12 0,000 0,03259358 0,05431522 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,03259358 0,0542782 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,03259358 0,05424122 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,03259358 0,0542043 ! defense response to fungus GO:0050832 15 12 0,000 0,03259358 0,05416743 ! developmental induction GO:0031128 22 12 0,000 0,03259358 0,0541306 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,03259358 0,05409383 ! lamellipodium assembly GO:0030032 24 12 0,000 0,03259358 0,05405711 ! response to cold GO:0009409 17 12 0,000 0,03259358 0,05402043 ! establishment of cell polarity GO:0030010 21 12 0,000 0,03259358 0,05398381 ! regulation of synapse organization GO:0050807 18 12 0,000 0,03259358 0,05394723 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,03526176 0,05832396 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03526176 0,0582845 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,03526176 0,05824509 ! regulation of chemokine production GO:0032642 18 13 0,000 0,03526176 0,05820573 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,03526176 0,05816643 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,03526176 0,05812718 ! peroxisomal transport GO:0043574 28 13 0,000 0,03526176 0,05808799 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,03526176 0,05804884 ! cartilage condensation GO:0001502 22 13 0,000 0,03526176 0,05800975 ! organelle fusion GO:0048284 36 13 0,000 0,03526176 0,05797072 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,03526176 0,05793173 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,03526176 0,0578928 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,03526176 0,05785392 ! endocrine pancreas development GO:0031018 25 13 0,000 0,03526176 0,05781509 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,03526176 0,05777631 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,03526176 0,05773759 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,03526176 0,05769892 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,03526176 0,0576603 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,03526176 0,05762173 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03526176 0,05758321 ! methionine metabolic process GO:0006555 31 13 0,000 0,03526176 0,05754475 ! plasma membrane organization GO:0007009 27 13 0,000 0,03526176 0,05750633 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,03526176 0,05746797 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,03526176 0,05742966 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,03526176 0,0573914 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,03526176 0,05735319 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,03526176 0,05731503 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,03526176 0,05727692 ! exocrine system development GO:0035272 34 13 0,000 0,03526176 0,05723886 ! asymmetric protein localization GO:0008105 24 13 0,000 0,03526176 0,05720085 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,03526176 0,0571629 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,03526176 0,05712499 ! L-glutamate transport GO:0015813 30 13 0,000 0,03526176 0,05708713 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,03526176 0,05704933 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,03526176 0,05701157 ! protein homotetramerization GO:0051289 24 13 0,000 0,03526176 0,05697387 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,03526176 0,05693621 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,03526176 0,0568986 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,03526176 0,05686105 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,03526176 0,05682354 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,03526176 0,05678608 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03526176 0,05674867 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,03526176 0,05671131 ! histone methylation GO:0016571 29 13 0,000 0,03526176 0,056674 ! chromatin silencing GO:0006342 29 13 0,000 0,03526176 0,05663674 ! gland morphogenesis GO:0022612 31 13 0,000 0,03526176 0,05659953 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,03526176 0,05656237 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03526176 0,05652525 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,03526176 0,05648819 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,03526176 0,05645117 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,03526176 0,0564142 ! spleen development GO:0048536 24 13 0,000 0,03526176 0,05637728 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,03526176 0,05634041 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,03526176 0,05630359 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,03526176 0,05626681 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03526176 0,05623008 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,03526176 0,0561934 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,03526176 0,05615677 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,03526176 0,05612019 ! insulin secretion GO:0030073 24 13 0,000 0,03526176 0,05608365 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,03526176 0,05604716 ! acrosome reaction GO:0007340 19 13 0,000 0,03526176 0,05601072 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,03526176 0,05597432 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,03526176 0,05593798 ! rRNA transcription GO:0009303 28 14 0,000 0,03792266 0,06012009 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,03792266 0,0600811 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,03792266 0,06004216 ! water transport GO:0006833 21 14 0,000 0,03792266 0,06000328 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,03792266 0,05996444 ! non-recombinational repair GO:0000726 29 14 0,000 0,03792266 0,05992565 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,03792266 0,05988692 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,03792266 0,05984823 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,03792266 0,05980959 ! RNA polyadenylation GO:0043631 32 14 0,000 0,03792266 0,059771 ! lipid localization GO:0010876 32 14 0,000 0,03792266 0,05973247 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,03792266 0,05969398 ! regulated secretory pathway GO:0045055 24 14 0,000 0,03792266 0,05965554 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,03792266 0,05961715 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,03792266 0,05957882 ! arginine metabolic process GO:0006525 21 14 0,000 0,03792266 0,05954053 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,03792266 0,05950228 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,03792266 0,05946409 ! regulation of heart rate GO:0002027 25 14 0,000 0,03792266 0,05942595 ! fear response GO:0042596 34 14 0,000 0,03792266 0,05938786 ! organic alcohol transport GO:0015850 29 14 0,000 0,03792266 0,05934981 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,03792266 0,05931182 ! embryo implantation GO:0007566 30 14 0,000 0,03792266 0,05927387 ! neutral amino acid transport GO:0015804 28 14 0,000 0,03792266 0,05923597 ! bone mineralization GO:0030282 18 14 0,000 0,03792266 0,05919812 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,03792266 0,05916032 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,03792266 0,05912256 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,03792266 0,05908486 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,03792266 0,0590472 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,03792266 0,05900959 ! ribosome assembly GO:0042255 18 14 0,000 0,03792266 0,05897203 ! cerebellum development GO:0021549 23 14 0,000 0,03792266 0,05893451 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,03792266 0,05889705 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,03792266 0,05885963 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,03792266 0,05882226 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,03792266 0,05878493 ! NADP metabolic process GO:0006739 24 14 0,000 0,03792266 0,05874766 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,03792266 0,05871043 ! oxygen transport GO:0015671 22 14 0,000 0,03792266 0,05867325 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,03792266 0,05863611 ! male genitalia development GO:0030539 26 14 0,000 0,03792266 0,05859902 ! regulation of axon extension GO:0030516 43 14 0,000 0,03792266 0,05856198 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,03792266 0,05852499 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,03792266 0,05848804 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,04057629 0,06254125 ! lactation GO:0007595 30 15 0,000 0,04057629 0,06250182 ! reproductive cellular process GO:0048610 22 15 0,000 0,04057629 0,06246243 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,04057629 0,0624231 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,04057629 0,06238382 ! superoxide anion generation GO:0042554 22 15 0,000 0,04057629 0,06234458 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,04057629 0,06230539 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,04057629 0,06226626 ! copper ion transport GO:0006825 22 15 0,000 0,04057629 0,06222717 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,04057629 0,06218813 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,04057629 0,06214914 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,04057629 0,0621102 ! sulfate transport GO:0008272 27 15 0,000 0,04057629 0,06207131 ! response to cAMP GO:0051591 25 15 0,000 0,04057629 0,06203247 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,04057629 0,06199367 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,04057629 0,06195493 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,04057629 0,06191623 ! response to hexose stimulus GO:0009746 25 15 0,000 0,04057629 0,06187758 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,04057629 0,06183898 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,04057629 0,06180043 ! vesicle coating GO:0006901 38 15 0,000 0,04057629 0,06176192 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,04057629 0,06172346 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,04057629 0,06168505 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,04057629 0,06164669 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,04057629 0,06160838 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,04057629 0,06157011 ! regulation of vasodilation GO:0042312 27 15 0,000 0,04057629 0,0615319 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,04057629 0,06149372 ! histone deacetylation GO:0016575 24 15 0,000 0,04057629 0,0614556 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,04057629 0,06141752 ! water homeostasis GO:0030104 28 15 0,000 0,04057629 0,06137949 ! cofactor transport GO:0051181 30 15 0,000 0,04057629 0,06134151 ! muscle maintenance GO:0046716 26 15 0,000 0,04057629 0,06130358 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,04057629 0,06126569 ! intestinal absorption GO:0050892 31 15 0,000 0,04057629 0,06122785 ! dopamine metabolic process GO:0042417 35 15 0,000 0,04057629 0,06119005 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,04057629 0,0611523 ! heme biosynthetic process GO:0006783 33 15 0,000 0,04057629 0,0611146 ! cell killing GO:0001906 32 15 0,000 0,04057629 0,06107695 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,04057629 0,06103934 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,04057629 0,06100177 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,04057629 0,06096426 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,04057629 0,06092679 ! actin filament polymerization GO:0030041 27 15 0,000 0,04057629 0,06088936 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,04057629 0,06085198 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,04322268 0,06478099 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04322268 0,06474127 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04322268 0,0647016 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04322268 0,06466198 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,04322268 0,0646224 ! bone remodeling GO:0046849 28 16 0,000 0,04322268 0,06458288 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04322268 0,0645434 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04322268 0,06450398 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04322268 0,0644646 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04322268 0,06442526 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04322268 0,06438598 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,04322268 0,06434675 ! startle response GO:0001964 28 16 0,000 0,04322268 0,06430756 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04322268 0,06426842 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04322268 0,06422932 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04322268 0,06419028 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04322268 0,06415128 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04322268 0,06411233 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04322268 0,06407343 ! response to osmotic stress GO:0006970 27 16 0,000 0,04322268 0,06403457 ! lysosomal transport GO:0007041 31 16 0,000 0,04322268 0,06399576 ! fructose metabolic process GO:0006000 25 16 0,000 0,04322268 0,063957 ! L-amino acid transport GO:0015807 33 16 0,000 0,04322268 0,06391829 ! stem cell development GO:0048864 46 16 0,000 0,04322268 0,06387962 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04322268 0,063841 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04322268 0,06380242 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04322268 0,06376389 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04322268 0,06372541 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04322268 0,06368698 ! axon cargo transport GO:0008088 46 16 0,000 0,04322268 0,06364859 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04322268 0,06361025 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,04322268 0,06357195 ! DNA replication initiation GO:0006270 28 16 0,000 0,04322268 0,0635337 ! neuron recognition GO:0008038 40 16 0,000 0,04322268 0,0634955 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04322268 0,06345734 ! tissue regeneration GO:0042246 27 16 0,000 0,04322268 0,06341922 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04322268 0,06338116 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04322268 0,06334314 ! biomineral formation GO:0031214 22 16 0,000 0,04322268 0,06330516 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04322268 0,06326723 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04322268 0,06322935 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,04322268 0,06319151 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04322268 0,06315371 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04322268 0,06311596 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04322268 0,06307826 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04322268 0,0630406 ! peptide hormone processing GO:0016486 27 16 0,000 0,04322268 0,06300299 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,04586184 0,06681007 ! metencephalon development GO:0022037 32 17 0,000 0,04586184 0,06677025 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,04586184 0,06673048 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,04586184 0,06669076 ! signal complex assembly GO:0007172 47 17 0,000 0,04586184 0,06665109 ! filopodium assembly GO:0046847 42 17 0,000 0,04586184 0,06661146 ! endothelial cell migration GO:0043542 31 17 0,000 0,04586184 0,06657189 ! gene silencing by RNA GO:0031047 38 17 0,000 0,04586184 0,06653235 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,04586184 0,06649287 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,04586184 0,06645343 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,04586184 0,06641404 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,04586184 0,06637469 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,04586184 0,0663354 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,04586184 0,06629614 ! myoblast differentiation GO:0045445 50 17 0,000 0,04586184 0,06625694 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,04586184 0,06621778 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,04586184 0,06617867 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,04586184 0,0661396 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,04586184 0,06610058 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,04586184 0,06606161 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,04586184 0,06602268 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,04586184 0,06598379 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,04586184 0,06594496 ! membrane budding GO:0006900 42 17 0,000 0,04586184 0,06590617 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,04586184 0,06586742 ! regulation of protein binding GO:0043393 33 17 0,000 0,04586184 0,06582872 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,04586184 0,06579007 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,04586184 0,06575146 ! genitalia development GO:0048806 32 17 0,000 0,04586184 0,06571289 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,04586184 0,06567438 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,04586184 0,0656359 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,04586184 0,06559747 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,04586184 0,06555909 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,04586184 0,06552075 ! steroid catabolic process GO:0006706 34 17 0,000 0,04586184 0,06548246 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,04586184 0,06544421 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,04586184 0,065406 ! gas transport GO:0015669 26 17 0,000 0,04586184 0,06536784 ! organic cation transport GO:0015695 32 17 0,000 0,04586184 0,06532973 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,04586184 0,06529166 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,04586184 0,06525363 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,0484938 0,0689583 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,0484938 0,06891818 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,0484938 0,06887811 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,0484938 0,06883809 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,0484938 0,06879812 ! adult walking behavior GO:0007628 36 18 0,000 0,0484938 0,06875819 ! patterning of blood vessels GO:0001569 43 18 0,000 0,0484938 0,0687183 ! heart looping GO:0001947 34 18 0,000 0,0484938 0,06867847 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,0484938 0,06863868 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,0484938 0,06859893 ! centrosome cycle GO:0007098 26 18 0,000 0,0484938 0,06855923 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,0484938 0,06851958 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,0484938 0,06847997 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,0484938 0,06844041 ! glycine metabolic process GO:0006544 30 18 0,000 0,0484938 0,0684009 ! glutamine metabolic process GO:0006541 29 18 0,000 0,0484938 0,06836143 ! response to retinoic acid GO:0032526 31 18 0,000 0,0484938 0,068322 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,0484938 0,06828263 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,0484938 0,06824329 ! DNA integration GO:0015074 32 18 0,000 0,0484938 0,068204 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,0484938 0,06816476 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,0484938 0,06812556 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,0484938 0,06808641 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,0484938 0,0680473 ! neural crest cell migration GO:0001755 41 18 0,000 0,0484938 0,06800824 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,0484938 0,06796922 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,0484938 0,06793025 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,0484938 0,06789132 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,0484938 0,06785244 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,0484938 0,0678136 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,0484938 0,0677748 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,0484938 0,06773605 ! detection of bacterium GO:0016045 22 18 0,000 0,0484938 0,06769735 ! defense response to virus GO:0051607 43 18 0,000 0,0484938 0,06765868 ! microspike assembly GO:0030035 46 18 0,000 0,0484938 0,06762007 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,0484938 0,06758149 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,0484938 0,06754296 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,05111857 0,07115822 ! positive regulation of translation GO:0045727 31 19 0,000 0,05111857 0,07111769 ! negative regulation of defense response GO:0031348 27 19 0,000 0,05111857 0,07107722 ! neuron maturation GO:0042551 46 19 0,000 0,05111857 0,07103679 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,05111857 0,0709964 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,05111857 0,07095606 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,05111857 0,07091577 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,05111857 0,07087552 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,05111857 0,07083532 ! inositol metabolic process GO:0006020 33 19 0,000 0,05111857 0,07079516 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,05111857 0,07075505 ! memory GO:0007613 34 19 0,000 0,05111857 0,07071499 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,05111857 0,07067497 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,05111857 0,07063499 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,05111857 0,07059507 ! pigmentation during development GO:0048066 42 19 0,000 0,05111857 0,07055518 ! response to vitamin A GO:0033189 32 19 0,000 0,05111857 0,07051534 ! heme metabolic process GO:0042168 40 19 0,000 0,05111857 0,07047555 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,05111857 0,0704358 ! response to fungus GO:0009620 26 19 0,000 0,05111857 0,07039609 ! peptide cross-linking GO:0018149 39 19 0,000 0,05111857 0,07035643 ! protein export from nucleus GO:0006611 40 19 0,000 0,05111857 0,07031682 ! heart process GO:0003015 32 19 0,000 0,05111857 0,07027725 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,05111857 0,07023772 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,05111857 0,07019824 ! visual learning GO:0008542 38 19 0,000 0,05111857 0,0701588 ! cellular pigmentation GO:0033059 37 19 0,000 0,05111857 0,07011941 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,05111857 0,07008006 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,05111857 0,07004076 ! vitamin transport GO:0051180 31 19 0,000 0,05111857 0,0700015 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,05111857 0,06996228 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,05111857 0,06992311 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,05111857 0,06988398 ! cilium assembly GO:0042384 38 19 0,000 0,05111857 0,06984489 ! peptide hormone secretion GO:0030072 32 19 0,000 0,05111857 0,06980585 ! protein secretion GO:0009306 45 20 0,000 0,05373618 0,07333937 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,05373618 0,07329842 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,05373618 0,07325752 ! positive regulation of ossification GO:0045778 50 20 0,000 0,05373618 0,07321666 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,05373618 0,07317585 ! skin development GO:0043588 42 20 0,000 0,05373618 0,07313508 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,05373618 0,07309436 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,05373618 0,07305369 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,05373618 0,07301306 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,05373618 0,07297247 ! response to vitamin GO:0033273 36 20 0,000 0,05373618 0,07293193 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,05373618 0,07289144 ! bile acid metabolic process GO:0008206 34 20 0,000 0,05373618 0,07285099 ! response to alkaloid GO:0043279 38 20 0,000 0,05373618 0,07281058 ! retinoid metabolic process GO:0001523 34 20 0,000 0,05373618 0,07277022 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,05373618 0,0727299 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,05373618 0,07268963 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,05373618 0,07264941 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,05373618 0,07260922 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,05373618 0,07256909 ! actin filament bundle formation GO:0051017 47 20 0,000 0,05373618 0,07252899 ! body fluid secretion GO:0007589 33 20 0,000 0,05373618 0,07248894 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,05373618 0,07244894 ! peptide secretion GO:0002790 38 20 0,000 0,05373618 0,07240898 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,05373618 0,07236906 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,05373618 0,07232919 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,05373618 0,07228936 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,05373618 0,07224957 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,05373618 0,07220983 ! cell-cell junction organization GO:0045216 43 20 0,000 0,05373618 0,07217014 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,05373618 0,07213048 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,05373618 0,07209087 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,05373618 0,0720513 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,05373618 0,07201178 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,05373618 0,0719723 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,05373618 0,07193286 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,05373618 0,07189347 ! negative regulation of translation GO:0017148 32 20 0,000 0,05373618 0,07185412 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,05373618 0,07181481 ! regulation of cell killing GO:0031341 46 21 0,000 0,05634663 0,07526234 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,05634663 0,07522121 ! hormone secretion GO:0046879 39 21 0,000 0,05634663 0,07518013 ! lipid phosphorylation GO:0046834 43 21 0,000 0,05634663 0,07513909 ! cAMP metabolic process GO:0046058 41 21 0,000 0,05634663 0,0750981 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,05634663 0,07505715 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,05634663 0,07501625 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,05634663 0,07497539 ! ovarian follicle development GO:0001541 39 21 0,000 0,05634663 0,07493458 ! smooth muscle contraction GO:0006939 48 21 0,000 0,05634663 0,07489381 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,05634663 0,07485308 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,05634663 0,0748124 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,05634663 0,07477177 ! plasma membrane fusion GO:0045026 33 21 0,000 0,05634663 0,07473117 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,05634663 0,07469062 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,05634663 0,07465012 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,05634663 0,07460966 ! sensory perception of pain GO:0019233 33 21 0,000 0,05634663 0,07456924 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,05634663 0,07452887 ! collagen fibril organization GO:0030199 62 21 0,000 0,05634663 0,07448854 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,05634663 0,07444825 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,05634663 0,07440801 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,05634663 0,07436781 ! collagen catabolic process GO:0030574 29 21 0,000 0,05634663 0,07432766 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,05634663 0,07428755 GO:0043450|alkene biosynthetic process, ! sperm-egg recognition GO:0035036 23 21 0,000 0,05634663 0,07424748 ! actin filament-based movement GO:0030048 47 21 0,000 0,05634663 0,07420745 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,05894996 0,07759416 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,05894996 0,07755237 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,05894996 0,07751063 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,05894996 0,07746894 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,05894996 0,07742729 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,05894996 0,07738568 ! microtubule-based transport GO:0010970 59 22 0,000 0,05894996 0,07734412 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,05894996 0,0773026 ! vacuolar transport GO:0007034 41 22 0,000 0,05894996 0,07726113 ! central nervous system neuron development GO:0021954 47 22 0,000 0,05894996 0,07721971 ! fucose metabolic process GO:0006004 44 22 0,000 0,05894996 0,07717832 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,05894996 0,07713699 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,05894996 0,07709569 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,05894996 0,07705444 ! stem cell differentiation GO:0048863 57 22 0,000 0,05894996 0,07701324 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,05894996 0,07697208 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,05894996 0,07693096 ! cytolysis GO:0019835 27 22 0,000 0,05894996 0,07688988 ! renal system process GO:0003014 42 22 0,000 0,05894996 0,07684885 ! vasodilation GO:0042311 40 22 0,000 0,05894996 0,07680787 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,05894996 0,07676693 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,05894996 0,07672603 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,05894996 0,07668517 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,05894996 0,07664436 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,05894996 0,07660359 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,05894996 0,07656287 ! sarcomere organization GO:0045214 32 22 0,000 0,05894996 0,07652219 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,05894996 0,07648155 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,05894996 0,07644095 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,05894996 0,0764004 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,05894996 0,07635989 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,05894996 0,07631942 ! protein stabilization GO:0050821 41 22 0,000 0,05894996 0,076279 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,06154618 0,07959625 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,06154618 0,07955414 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,06154618 0,07951207 ! gluconeogenesis GO:0006094 38 23 0,000 0,06154618 0,07947004 ! glycerol metabolic process GO:0006071 40 23 0,000 0,06154618 0,07942806 ! viral genome replication GO:0019079 44 23 0,000 0,06154618 0,07938612 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,06154618 0,07934423 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,06154618 0,07930238 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,06154618 0,07926058 ! regeneration GO:0031099 42 23 0,000 0,06154618 0,07921882 ! visual behavior GO:0007632 46 23 0,000 0,06154618 0,0791771 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,06154618 0,07913543 ! response to ethanol GO:0045471 47 23 0,000 0,06154618 0,0790938 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,06154618 0,07905222 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,06154618 0,07901068 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,06154618 0,07896918 ! peroxisome organization GO:0007031 43 23 0,000 0,06154618 0,07892773 ! lysosome organization GO:0007040 47 23 0,000 0,06154618 0,07888632 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,06154618 0,07884495 ! vesicle targeting GO:0006903 49 23 0,000 0,06154618 0,07880362 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,06154618 0,07876234 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,06154618 0,07872111 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,06154618 0,07867991 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,06154618 0,07863876 ! DNA modification GO:0006304 36 23 0,000 0,06154618 0,07859766 ! fatty acid transport GO:0015908 47 23 0,000 0,06154618 0,07855659 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,06154618 0,07851557 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,06154618 0,07847459 ! hormone transport GO:0009914 41 23 0,000 0,06154618 0,07843365 ! cell-cell recognition GO:0009988 28 23 0,000 0,06154618 0,07839276 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,06154618 0,07835191 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,06154618 0,0783111 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,06154618 0,07827034 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,06413531 0,08152058 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,06413531 0,08147819 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,06413531 0,08143584 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,06413531 0,08139354 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,06413531 0,08135128 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,06413531 0,08130906 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,06413531 0,08126689 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,06413531 0,08122476 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,06413531 0,08118267 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,06413531 0,08114063 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,06413531 0,08109863 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,06413531 0,08105668 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,06413531 0,08101477 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,06413531 0,0809729 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,06413531 0,08093107 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,06413531 0,08088929 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,06413531 0,08084755 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,06413531 0,08080586 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,06413531 0,08076421 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,06413531 0,0807226 ! membrane depolarization GO:0051899 45 24 0,000 0,06413531 0,08068103 ! oogenesis GO:0048477 44 24 0,000 0,06413531 0,08063951 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,06413531 0,08059802 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,06413531 0,08055659 ! platelet activation GO:0030168 41 24 0,000 0,06413531 0,08051519 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,06413531 0,08047384 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,06413531 0,08043253 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,06413531 0,08039126 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,06413531 0,08035003 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,06413531 0,08030885 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,06413531 0,08026771 ! regulation of amine transport GO:0051952 41 24 0,000 0,06413531 0,08022661 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,06413531 0,08018555 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,06671737 0,08337112 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,06671737 0,08332849 ! leukocyte adhesion GO:0007159 55 25 0,000 0,06671737 0,08328591 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,06671737 0,08324338 ! phototransduction GO:0007602 37 25 0,000 0,06671737 0,08320088 ! keratinization GO:0031424 37 25 0,000 0,06671737 0,08315843 ! vacuole organization GO:0007033 49 25 0,000 0,06671737 0,08311603 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,06671737 0,08307366 ! receptor metabolic process GO:0043112 53 25 0,000 0,06671737 0,08303135 ! chromosome condensation GO:0030261 48 25 0,000 0,06671737 0,08298907 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,06671737 0,08294683 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,06671737 0,08290464 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,06671737 0,0828625 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,06671737 0,08282039 ! immunoglobulin production GO:0002377 62 25 0,000 0,06671737 0,08277833 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,06671737 0,08273631 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,06671737 0,08269433 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,06671737 0,0826524 ! liver development GO:0001889 55 25 0,000 0,06671737 0,08261051 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,06929238 0,08575546 ! initiation of viral infection GO:0019059 60 26 0,000 0,06929238 0,08571204 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,06929238 0,08566866 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,06929238 0,08562533 ! molting cycle process GO:0022404 52 26 0,000 0,06929238 0,08558204 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,06929238 0,08553879 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,06929238 0,08549559 GO:0051297|centrosome organization, ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,06929238 0,08545244 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,06929238 0,08540932 ! digestive system process GO:0022600 49 26 0,000 0,06929238 0,08536625 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,06929238 0,08532322 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,06929238 0,08528024 ! osteoblast differentiation GO:0001649 63 26 0,000 0,06929238 0,0852373 ! neural crest cell development GO:0014032 59 26 0,000 0,06929238 0,0851944 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,06929238 0,08515155 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,06929238 0,08510874 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,06929238 0,08506597 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,06929238 0,08502324 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,06929238 0,08498056 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,06929238 0,08493792 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,06929238 0,08489532 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,06929238 0,08485277 GO:0045840|positive regulation of mitosis, ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,06929238 0,08481026 ! blastocyst development GO:0001824 50 26 0,000 0,06929238 0,08476779 ! telomere organization GO:0032200 46 26 0,000 0,06929238 0,08472536 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,06929238 0,08468298 ! alditol metabolic process GO:0019400 44 26 0,000 0,06929238 0,08464064 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,06929238 0,08459834 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,07186035 0,08768973 ! embryonic pattern specification GO:0009880 49 27 0,000 0,07186035 0,08764595 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,07186035 0,08760221 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,07186035 0,08755852 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,07186035 0,08751487 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,07186035 0,08747127 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,07186035 0,08742771 ! iron ion transport GO:0006826 65 27 0,000 0,07186035 0,08738419 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,07186035 0,08734072 ! superoxide metabolic process GO:0006801 41 27 0,000 0,07186035 0,08729728 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,07186035 0,0872539 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,07186035 0,08721055 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,07186035 0,08716725 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,07186035 0,08712399 ! leukocyte proliferation GO:0070661 59 27 0,000 0,07186035 0,08708077 GO:0032943|mononuclear cell proliferation, ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,07442131 0,09013945 ! vesicle docking GO:0048278 55 28 0,000 0,07442131 0,09009478 ! circadian rhythm GO:0007623 56 28 0,000 0,07442131 0,09005016 ! dendrite development GO:0016358 67 28 0,000 0,07442131 0,09000558 ! fat cell differentiation GO:0045444 57 28 0,000 0,07442131 0,08996104 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,07442131 0,08991655 ! sperm motility GO:0030317 37 28 0,000 0,07442131 0,0898721 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,07442131 0,0898277 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,07442131 0,08978334 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,07442131 0,08973903 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,07442131 0,08969475 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,07442131 0,08965053 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,07442131 0,08960634 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,07442131 0,0895622 ! glutathione metabolic process GO:0006749 42 28 0,000 0,07442131 0,0895181 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,07442131 0,08947405 ! lipid oxidation GO:0034440 48 28 0,000 0,07442131 0,08943004 GO:0019395|fatty acid oxidation, ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,07442131 0,08938607 ! translational initiation GO:0006413 66 29 0,000 0,07697528 0,09240816 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,07697528 0,09236278 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,07697528 0,09231743 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,07697528 0,09227213 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,07697528 0,09222688 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,07697528 0,09218167 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,07697528 0,09213651 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,07697528 0,09209139 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,07697528 0,09204631 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,07697528 0,09200128 ! synaptogenesis GO:0007416 46 29 0,000 0,07697528 0,09195629 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,07697528 0,09191134 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,07697528 0,09186644 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,07697528 0,09182159 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,07697528 0,09177677 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,07952227 0,09476727 ! phenol metabolic process GO:0018958 56 30 0,000 0,07952227 0,09472107 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,07952227 0,09467491 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,07952227 0,09462879 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,07952227 0,09458272 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,07952227 0,0945367 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,07952227 0,09449072 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,07952227 0,09444478 ! acute-phase response GO:0006953 50 30 0,000 0,07952227 0,09439889 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,07952227 0,09435304 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,07952227 0,09430724 ! myofibril assembly GO:0030239 50 30 0,000 0,07952227 0,09426148 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,07952227 0,09421577 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,07952227 0,0941701 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,07952227 0,09412447 ! cell fate determination GO:0001709 64 30 0,000 0,07952227 0,09407889 ! phospholipid transport GO:0015914 65 30 0,000 0,07952227 0,09403336 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,07952227 0,09398786 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,07952227 0,09394241 GO:0046496|nicotinamide nucleotide metabolic process, ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,07952227 0,09389701 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,07952227 0,09385165 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,07952227 0,09380633 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,08206231 0,0967559 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,08206231 0,09670922 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,08206231 0,09666259 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,08206231 0,09661601 ! cell junction assembly GO:0034329 85 31 0,000 0,08206231 0,09656947 ! regulation of innate immune response GO:0045088 57 31 0,000 0,08206231 0,09652297 ! ovulation cycle process GO:0022602 55 31 0,000 0,08206231 0,09647652 ! peptide transport GO:0015833 60 31 0,000 0,08206231 0,09643012 ! male gonad development GO:0008584 56 31 0,000 0,08206231 0,09638376 ! iron ion homeostasis GO:0055072 60 31 0,000 0,08206231 0,09633744 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,08206231 0,09629117 ! detection of light stimulus GO:0009583 44 31 0,000 0,08206231 0,09624494 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,08206231 0,09619876 ! natural killer cell activation GO:0030101 50 31 0,000 0,08206231 0,09615262 ! cofactor catabolic process GO:0051187 54 31 0,000 0,08206231 0,09610653 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,08206231 0,09606048 ! response to heat GO:0009408 54 31 0,000 0,08206231 0,09601447 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,08206231 0,09596851 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,08459541 0,09888353 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,08459541 0,09883624 ! collagen metabolic process GO:0032963 49 32 0,000 0,08459541 0,09878899 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,08459541 0,09874179 ! spindle organization GO:0007051 50 32 0,000 0,08459541 0,09869464 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,08459541 0,09864753 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,08459541 0,09860047 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,08459541 0,09855345 ! muscle cell development GO:0055001 52 32 0,000 0,08459541 0,09850647 ! mesoderm formation GO:0001707 73 32 0,000 0,08459541 0,09845954 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,08459541 0,09841266 ! ovulation cycle GO:0042698 57 32 0,000 0,08459541 0,09836581 ! BMP signaling pathway GO:0030509 71 32 0,000 0,08459541 0,09831902 ! hindbrain development GO:0030902 65 32 0,000 0,08459541 0,09827227 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,08459541 0,09822556 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,08459541 0,0981789 ! gene silencing GO:0016458 71 32 0,000 0,08459541 0,09813228 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,08712158 0,10101473 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,08712158 0,10096681 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,08712158 0,10091893 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,08712158 0,1008711 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,08712158 0,10082332 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,08712158 0,10077558 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,08712158 0,10072789 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,08712158 0,10068024 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,08712158 0,10063264 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,08964086 0,10349368 ! post-embryonic development GO:0009791 76 34 0,000 0,08964086 0,10344479 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,08964086 0,10339595 ! cholesterol transport GO:0030301 62 34 0,000 0,08964086 0,10334716 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,08964086 0,10329841 ! spliceosome assembly GO:0000245 75 34 0,000 0,08964086 0,10324971 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,08964086 0,10320105 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,08964086 0,10315244 ! formation of primary germ layer GO:0001704 76 34 0,000 0,08964086 0,10310387 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,08964086 0,10305535 ! adult locomotory behavior GO:0008344 62 34 0,000 0,08964086 0,10300688 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,09215326 0,1058441 ! negative regulation of secretion GO:0051048 68 35 0,000 0,09215326 0,10579437 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,09215326 0,10574467 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,09215326 0,10569503 ! membrane docking GO:0022406 69 35 0,000 0,09215326 0,10564543 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,09215326 0,10559588 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,09215326 0,10554637 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,09215326 0,10549691 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,09215326 0,1054475 ! ceramide metabolic process GO:0006672 72 35 0,000 0,09215326 0,10539813 ! sterol transport GO:0015918 63 35 0,000 0,09215326 0,10534881 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,09215326 0,10529954 ! placenta development GO:0001890 53 35 0,000 0,09215326 0,10525031 ! vesicle localization GO:0051648 70 35 0,000 0,09215326 0,10520113 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,09465879 0,10801094 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,09465879 0,10796052 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,09465879 0,10791014 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,09465879 0,10785981 ! positive regulation of cell development GO:0010720 85 36 0,000 0,09465879 0,10780952 ! protein targeting to membrane GO:0006612 75 36 0,000 0,09465879 0,10775929 ! regulation of proteolysis GO:0030162 77 36 0,000 0,09465879 0,1077091 ! aerobic respiration GO:0009060 56 36 0,000 0,09465879 0,10765895 ! cytokine production GO:0001816 68 36 0,000 0,09465879 0,10760885 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,09465879 0,1075588 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,09465879 0,1075088 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,09715748 0,11029541 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,09715748 0,11024418 ! sister chromatid segregation GO:0000819 65 37 0,000 0,09715748 0,110193 ! actomyosin structure organization GO:0031032 68 37 0,000 0,09715748 0,11014187 ! cell junction organization GO:0034330 96 37 0,000 0,09715748 0,11009078 ! female gonad development GO:0008585 71 37 0,000 0,09715748 0,11003974 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,09715748 0,10998875 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,09715748 0,10993781 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,09964934 0,11270525 ! meiosis I GO:0007127 74 38 0,000 0,09964934 0,1126531 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,09964934 0,11260099 ! organic anion transport GO:0015711 82 38 0,000 0,09964934 0,11254893 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,09964934 0,11249693 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,09964934 0,11244496 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,09964934 0,11239305 ! regulation of protein stability GO:0031647 77 38 0,000 0,09964934 0,11234118 ! spermatid development GO:0007286 69 38 0,000 0,09964934 0,11228937 ! glycogen metabolic process GO:0005977 63 38 0,000 0,09964934 0,1122376 ! pigment metabolic process GO:0042440 87 38 0,000 0,09964934 0,11218587 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,1021344 0,1149306 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,1021344 0,11487769 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,1021344 0,11482482 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,1021344 0,114772 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,1021344 0,11471923 ! glucan metabolic process GO:0044042 64 39 0,000 0,1021344 0,11466651 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,10461266 0,11739492 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,10461266 0,11734102 ! learning GO:0007612 82 40 0,000 0,10461266 0,11728717 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,10461266 0,11723337 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,10461266 0,11717961 ! lipid homeostasis GO:0055088 75 40 0,000 0,10461266 0,11712591 ! mismatch repair GO:0006298 58 40 0,000 0,10461266 0,11707226 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,10461266 0,11701865 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,10461266 0,1169651 ! RNA export from nucleus GO:0006405 61 41 0,000 0,10708416 0,11967365 ! mRNA catabolic process GO:0006402 79 41 0,000 0,10708416 0,11961893 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,10708416 0,11956426 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,10708416 0,11950964 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,10708416 0,11945507 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,10708416 0,11940055 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,10708416 0,11934608 ! feeding behavior GO:0007631 69 41 0,000 0,10708416 0,11929166 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,10708416 0,11923728 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,10708416 0,11918296 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,10708416 0,11912869 ! RNA modification GO:0009451 64 41 0,000 0,10708416 0,11907447 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,1095489 0,12175977 ! ear morphogenesis GO:0042471 64 42 0,000 0,1095489 0,1217044 ! organic ether metabolic process GO:0018904 59 42 0,000 0,1095489 0,12164908 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,1095489 0,12159381 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,1095489 0,12153859 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,1095489 0,12148342 ! regulation of protein secretion GO:0050708 77 42 0,000 0,1095489 0,1214283 ! cytokinesis GO:0000910 84 42 0,000 0,1095489 0,12137323 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,11200691 0,12404029 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,11200691 0,12398409 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,11200691 0,12392794 ! regulation of tube size GO:0035150 76 43 0,000 0,11200691 0,12387183 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,11200691 0,12381578 ! glucose transport GO:0015758 66 43 0,000 0,11200691 0,12375978 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,11200691 0,12370383 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,11200691 0,12364794 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,11200691 0,12359209 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,11200691 0,12353629 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,11200691 0,12348054 ! ion transmembrane transport GO:0034220 79 43 0,000 0,11200691 0,12342484 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,1144582 0,12606916 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,1144582 0,12601234 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,1144582 0,12595558 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,1144582 0,12589887 ! hexose transport GO:0008645 68 44 0,000 0,1144582 0,12584221 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,1144582 0,1257856 ! striated muscle contraction GO:0006941 85 44 0,000 0,1144582 0,12572904 ! phagocytosis GO:0006909 105 44 0,000 0,1144582 0,12567253 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,1144582 0,12561608 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,1169028 0,12824137 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,1169028 0,12818381 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,1169028 0,1281263 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,1169028 0,12806885 ! female gamete generation GO:0007292 71 45 0,000 0,1169028 0,12801144 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,1169028 0,12795409 ! polyol metabolic process GO:0019751 77 45 0,000 0,1169028 0,12789679 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,11934071 0,13050553 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,11934071 0,13044714 ! glycolysis GO:0006096 71 46 0,000 0,11934071 0,1303888 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,11934071 0,13033051 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,11934071 0,13027228 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,11934071 0,13021409 ! pigmentation GO:0043473 103 46 0,000 0,11934071 0,13015596 ! cell growth GO:0016049 90 46 0,000 0,11934071 0,13009788 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,12419657 0,13533106 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,12419657 0,13527072 ! cellular component disassembly GO:0022411 89 48 0,000 0,12419657 0,13521044 ! endosome transport GO:0016197 127 48 0,000 0,12419657 0,13515021 ! male sex differentiation GO:0046661 93 48 0,000 0,12419657 0,13509004 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,12419657 0,13502992 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,12419657 0,13496985 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,12419657 0,13490984 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,12661456 0,13747527 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,12661456 0,1374142 ! regulation of ion transport GO:0043269 86 50 0,000 0,12902593 0,13996907 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,12902593 0,13990695 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,12902593 0,13984488 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,12902593 0,13978286 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,12902593 0,1397209 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,12902593 0,13965899 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,12902593 0,13959714 ! viral infectious cycle GO:0019058 104 51 0,000 0,13143072 0,14213601 ! peptide metabolic process GO:0006518 80 51 0,000 0,13143072 0,14207312 ! response to temperature stimulus GO:0009266 84 51 0,000 0,13143072 0,14201028 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,13143072 0,1419475 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,13382893 0,14447374 ! Notch signaling pathway GO:0007219 111 52 0,000 0,13382893 0,14440993 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,13382893 0,14434617 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,13382893 0,14428247 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,13382893 0,14421883 ! excretion GO:0007588 87 52 0,000 0,13382893 0,14415524 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,13382893 0,1440917 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,13382893 0,14402823 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,13382893 0,14396481 ! amino acid activation GO:0043038 98 52 0,000 0,13382893 0,14390144 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,13622059 0,14640867 ! inner ear development GO:0048839 89 53 0,000 0,13622059 0,14634428 ! chromatin remodeling GO:0006338 122 53 0,000 0,13622059 0,14627996 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,13622059 0,14621569 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,13622059 0,14615147 ! vesicle organization GO:0016050 127 53 0,000 0,13622059 0,14608731 ! regulation of translational initiation GO:0006446 87 54 0,000 0,13860571 0,14857997 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,13860571 0,1485148 ! neuromuscular process GO:0050905 107 54 0,000 0,13860571 0,1484497 ! membrane fusion GO:0006944 122 54 0,000 0,13860571 0,14838464 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,13860571 0,14831965 ! RNA catabolic process GO:0006401 103 55 0,000 0,14098432 0,1507989 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,14098432 0,1507329 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,14098432 0,15066697 ! cell recognition GO:0008037 98 55 0,000 0,14098432 0,15060109 ! cell maturation GO:0048469 107 55 0,000 0,14098432 0,15053526 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,14098432 0,1504695 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,14098432 0,15040379 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,14335642 0,15286762 ! glucose catabolic process GO:0006007 88 56 0,000 0,14335642 0,15280093 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,14335642 0,15273429 ! RNA elongation GO:0006354 90 56 0,000 0,14335642 0,15266771 ! chloride transport GO:0006821 102 57 0,000 0,14572204 0,15511936 ! regulation of actin filament length GO:0030832 118 58 0,000 0,14808119 0,157562 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,14808119 0,1574934 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,14808119 0,15742487 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,14808119 0,15735639 ! gastrulation GO:0007369 122 58 0,000 0,14808119 0,15728798 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,14808119 0,15721962 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,14808119 0,15715132 ! nuclear export GO:0051168 110 59 0,000 0,15043389 0,15957881 ! establishment of organelle localization GO:0051656 122 59 0,000 0,15043389 0,15950955 ! lipid modification GO:0030258 112 60 0,000 0,15278016 0,16192709 ! DNA catabolic process GO:0006308 94 60 0,000 0,15278016 0,16185687 ! regulation of endocytosis GO:0030100 104 60 0,000 0,15278016 0,16178671 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,15278016 0,16171661 ! adult behavior GO:0030534 104 60 0,000 0,15278016 0,16164658 ! positive regulation of secretion GO:0051047 110 61 0,000 0,15512002 0,16405118 ! regulation of cellular component size GO:0032535 125 61 0,000 0,15512002 0,16398019 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,15512002 0,16390926 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,15512002 0,1638384 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,15512002 0,1637676 ! proton transport GO:0015992 117 61 0,000 0,15512002 0,16369685 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,15745349 0,16608759 ! tRNA processing GO:0008033 102 62 0,000 0,15745349 0,16601591 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,15978057 0,16839686 ! mesoderm development GO:0007498 128 63 0,000 0,15978057 0,16832425 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,15978057 0,16825169 ! hydrogen transport GO:0006818 121 64 0,000 0,16210129 0,17062191 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,16210129 0,17054843 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,16441567 0,17290894 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,16441567 0,17283454 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,16441567 0,1727602 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,16441567 0,17268593 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,16441567 0,17261172 ! ear development GO:0043583 114 66 0,000 0,16672372 0,17495964 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,16672372 0,17488452 ! gonad development GO:0008406 115 66 0,000 0,16672372 0,17480946 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,16902545 0,1771468 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,16902545 0,17707083 ! secondary metabolic process GO:0019748 125 67 0,000 0,16902545 0,17699493 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,16902545 0,1769191 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,1713209 0,17924495 ! hexose catabolic process GO:0019320 113 68 0,000 0,1713209 0,17916822 ! extracellular matrix organization GO:0030198 146 68 0,000 0,1713209 0,17909155 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,1713209 0,17901495 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,1713209 0,17893842 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,1713209 0,17886195 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,1713209 0,17878554 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,17361007 0,18109709 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,17361007 0,1810198 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,17361007 0,18094257 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,17361007 0,18086541 ! developmental maturation GO:0021700 128 69 0,000 0,17361007 0,18078832 ! single fertilization GO:0007338 83 69 0,000 0,17361007 0,18071129 ! cell redox homeostasis GO:0045454 114 70 0,000 0,17589298 0,1830096 ! germ cell development GO:0007281 133 70 0,000 0,17589298 0,18293169 ! activation of immune response GO:0002253 120 70 0,000 0,17589298 0,18285385 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,17589298 0,18277607 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,17816964 0,18506311 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,17816964 0,18498446 ! carbohydrate transport GO:0008643 114 72 0,000 0,18044009 0,18726216 ! actin filament organization GO:0007015 167 72 0,000 0,18044009 0,18718264 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,18044009 0,1871032 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,18044009 0,18702381 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,18044009 0,1869445 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,18044009 0,18686525 ! humoral immune response GO:0006959 115 73 0,000 0,18270432 0,18912994 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,18270432 0,18904983 ! regulation of immune effector process GO:0002697 156 73 0,000 0,18270432 0,18896979 ! acute inflammatory response GO:0002526 118 74 0,000 0,18496236 0,19122431 ! amino acid transport GO:0006865 148 74 0,000 0,18496236 0,19114342 ! organelle localization GO:0051640 155 74 0,000 0,18496236 0,1910626 ! transition metal ion transport GO:0000041 143 75 0,000 0,18721423 0,193307 ! reproductive structure development GO:0048608 131 75 0,000 0,18721423 0,19322533 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,18721423 0,19314373 ! rhythmic process GO:0048511 142 75 0,000 0,18721423 0,1930622 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,18945993 0,19529562 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,18945993 0,19521325 ! regulation of blood pressure GO:0008217 134 76 0,000 0,18945993 0,19513095 ! amine catabolic process GO:0009310 136 77 0,000 0,1916995 0,19735435 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,1916995 0,19727122 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,1916995 0,19718816 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,1916995 0,19710517 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,1916995 0,19702225 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,19393294 0,19923388 ! antigen processing and presentation GO:0019882 117 78 0,000 0,19393294 0,19915014 ! fertilization GO:0009566 99 78 0,000 0,19393294 0,19906646 ! blood coagulation GO:0007596 151 79 0,000 0,19616027 0,20126818 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,19616027 0,20118369 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,19616027 0,20109926 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,19616027 0,20101491 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,19616027 0,20093063 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,19616027 0,20084641 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,19838151 0,20303562 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,19838151 0,2029506 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,19838151 0,20286565 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,19838151 0,20278077 ! meiosis GO:0007126 143 81 0,000 0,20059668 0,2049593 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 0,000 0,20059668 0,20487361 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,20059668 0,204788 ! meiotic cell cycle GO:0051321 144 82 0,000 0,20280578 0,20695678 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,20500885 0,20911758 ! exocytosis GO:0006887 153 83 0,000 0,20500885 0,20903031 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,20500885 0,2089431 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,20500885 0,20885597 ! inorganic anion transport GO:0015698 156 83 0,000 0,20500885 0,20876891 ! response to nutrient GO:0007584 135 84 0,000 0,20720588 0,21091832 ! digestion GO:0007586 130 84 0,000 0,20720588 0,21083048 ! regulation of ligase activity GO:0051340 147 84 0,000 0,20720588 0,2107427 ! hemostasis GO:0007599 165 85 0,000 0,20939691 0,2128825 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,20939691 0,21279395 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,20939691 0,21270547 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,20939691 0,21261706 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,21158195 0,21474644 ! regulation of lyase activity GO:0051339 169 86 0,000 0,21158195 0,21465726 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,213761 0,21677797 ! alcohol catabolic process GO:0046164 142 87 0,000 0,213761 0,21668802 ! nucleosome assembly GO:0006334 126 87 0,000 0,213761 0,21659814 ! cellular respiration GO:0045333 143 88 0,000 0,2159341 0,21870937 ! amine biosynthetic process GO:0009309 146 88 0,000 0,2159341 0,21861873 ! sensory perception of smell GO:0007608 117 88 0,000 0,2159341 0,21852817 ! chromatin assembly GO:0031497 128 88 0,000 0,2159341 0,21843768 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,21810125 0,22053864 ! cellular defense response GO:0006968 123 89 0,000 0,21810125 0,22044739 ! regulation of neurological system process GO:0031644 175 89 0,000 0,21810125 0,22035622 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,22026247 0,22244779 ! response to unfolded protein GO:0006986 139 90 0,000 0,22026247 0,22235587 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,22241777 0,22443892 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,22241777 0,22434625 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,22456718 0,22642081 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,22671071 0,22848774 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,22671071 0,22839352 ! vitamin metabolic process GO:0006766 153 93 0,000 0,22671071 0,22829937 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,22884838 0,23035706 ! female pregnancy GO:0007565 166 94 0,000 0,22884838 0,23026219 ! sterol metabolic process GO:0016125 166 94 0,000 0,22884838 0,23016739 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,22884838 0,23007267 ! nucleosome organization GO:0034728 143 95 0,000 0,23098019 0,23212037 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,23098019 0,23202492 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,23098019 0,23192956 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,23098019 0,23183427 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,23098019 0,23173906 ! sex differentiation GO:0007548 171 96 0,000 0,23310618 0,23377602 ! response to protein stimulus GO:0051789 158 96 0,000 0,23310618 0,23368009 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,23522634 0,23570876 ! transcription initiation GO:0006352 171 97 0,000 0,23522634 0,23561212 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,2373407 0,23763252 ! mRNA transport GO:0051028 185 100 0,000 0,24155209 0,24175 ! positive regulation of immune response GO:0050778 175 100 0,000 0,24155209 0,241651 ! hormone metabolic process GO:0042445 171 100 0,000 0,24155209 0,24155209